FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Borodin, O Olguin, M Jow, TR Spear, C Knap, J Leiter, K AF Borodin, Oleg Olguin, Marco Jow, T. Richard Spear, Carrie Knap, Jaroslaw Leiter, Kenneth TI Oxidation stability and decomposition reactions of battery electrolytes and additives in bulk and at interfaces SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Borodin, Oleg; Olguin, Marco; Jow, T. Richard] Army Res Lab, Adelphi, MD 20789 USA. [Spear, Carrie; Knap, Jaroslaw; Leiter, Kenneth] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM olegutah@gmail.com RI Borodin, Oleg/B-6855-2012 OI Borodin, Oleg/0000-0002-9428-5291 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 130-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165104369 ER PT J AU Chudomel, JM Shi, JM Forsythe, EW AF Chudomel, J. Matthew Shi, Jianmin Forsythe, Eric W. TI Synthesis of a class of efficient blue photoluminescent molecules based on a benzotriimidazole core SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Chudomel, J. Matthew; Shi, Jianmin; Forsythe, Eric W.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. EM jchudome@gmail.com NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 830-ORGN PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8KC UT WOS:000349167403395 ER PT J AU Garcia-Reyero, N Habib, T Villeneuve, D Escalon, L Ankley, G Perkins, E AF Garcia-Reyero, Natalia Habib, Tanwir Villeneuve, Daniel Escalon, Lynn Ankley, Gerald Perkins, Edward TI Systems approach to detect and evaluate contaminants of emerging concern in the Great Lakes SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS 39759 USA. [Habib, Tanwir] Badger Tech Serv, San Antonio, TX USA. [Villeneuve, Daniel; Ankley, Gerald] US EPA, Natl Hlth & Environm Effects Res Lab, Duluth, MN USA. [Escalon, Lynn; Perkins, Edward] US Army Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. EM nvinas@igbb.msstate.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 9-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165105454 ER PT J AU Golius, A Isayev, O Gorb, L Hill, FC Leszczynski, J AF Golius, Anastasiia Isayev, Olexander Gorb, Leonid Hill, Frances C. Leszczynski, Jerzy TI Energetic compounds as environmental contaminants: Theoretical studies SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Golius, Anastasiia; Leszczynski, Jerzy] Jackson State Univ, Dept Chem & Biochem, Jackson, MS 39217 USA. [Isayev, Olexander] Univ N Carolina, UNC Eshelman Sch Pharm, Div Chem Biol & Med Chem, Chapel Hill, NC USA. [Gorb, Leonid] Badger Tech Serv LLC, Vicksburg, MS USA. [Hill, Frances C.] US Army Engineer Res & Dev Ctr, Vicksburg, MS USA. EM anastasia@icnanotox.org NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 118-TOXI PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8KC UT WOS:000349167406270 ER PT J AU Haskins, J Bennett, WR Hernandez-Lugo, DM Wu, J Borodin, O Monk, JD Bauschlicher, CW Lawson, J AF Haskins, Justin Bennett, William R. Hernandez-Lugo, Dione M. Wu, James Borodin, Oleg Monk, Joshua D. Bauschlicher, Charles W. Lawson, John TI Investigation of structure and transport in Li-doped ionic liquid electrolytes: [pyr14][TFSI], [pyr13][FSI], and [EMIM][BF4] SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Haskins, Justin; Monk, Joshua D.; Bauschlicher, Charles W.; Lawson, John] NASA, Ames Res Ctr, Moffett Field, CA 94035 USA. [Bennett, William R.; Hernandez-Lugo, Dione M.; Wu, James] NASA, Glenn Res Ctr, Cleveland, OH 44135 USA. [Borodin, Oleg] US Army Res Lab, Adelphi, MD 20783 USA. EM justin.b.haskins@nasa.gov RI Borodin, Oleg/B-6855-2012 OI Borodin, Oleg/0000-0002-9428-5291 NR 0 TC 0 Z9 0 U1 1 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 629-PHYS PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8KC UT WOS:000349167404333 ER PT J AU Hu, FS LaScala, J Sadler, J Palmese, G AF Hu, Fengshuo LaScala, John Sadler, Joshua Palmese, Giuseppe TI Synthesis and characterization of thermosetting furan-based epoxy systems SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Hu, Fengshuo; Palmese, Giuseppe] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. [LaScala, John; Sadler, Joshua] Army Res Labs, Aberdeen Proving Ground, MD 21005 USA. EM fh83@drexel.edu NR 0 TC 0 Z9 0 U1 4 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 742-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8KC UT WOS:000349167406031 ER PT J AU Lambeth, RH Jackson, A Beyer, F AF Lambeth, Robert H. Jackson, Aaron Beyer, Frederick TI Model metallo-supramolecular crosslinked polymers with tunable properties SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Lambeth, Robert H.; Jackson, Aaron; Beyer, Frederick] ARL, Aberdeen Proving Ground, MD 21921 USA. EM robert.h.lambeth2.civ@mail.mil NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 46-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8KC UT WOS:000349167405182 ER PT J AU O'Neil, J Lewis, EA Lum, JS AF O'Neil, Jacklyn Lewis, Emily A. Lum, June S. TI Increased participation of younger chemists into YCC and Northeastern Section activities and the tangential opportunity for chemistry education SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [O'Neil, Jacklyn] Alkermes, Dept Pharmaceut Chem & Formulat, Waltham, MA 02451 USA. [Lewis, Emily A.] Tufts Univ, Dept Chem, Medford, MA 02155 USA. [Lum, June S.] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. [O'Neil, Jacklyn; Lewis, Emily A.; Lum, June S.] Northeastern Sect Younger Chem Comm, Boston, MA USA. EM jacklyn.oneil@alkermes.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 113-CHED PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165102763 ER PT J AU Perkins, EJ Habib, T Escalon, L Villenueve, DL Ankley, GT Garcia-Reyero, N AF Perkins, Edward J. Habib, Tanwir Escalon, Lynn Villenueve, Daniel L. Ankley, Gerald T. Garcia-Reyero, Natalia TI Inference of chemicals that cause biological effects in treated pulp and paper mill effluent using gene expression in caged fathead minnows SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Perkins, Edward J.; Escalon, Lynn] US Army Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Habib, Tanwir] Badger Tech Serv, San Antonio, TX 78216 USA. [Villenueve, Daniel L.; Ankley, Gerald T.] US EPA, Natl Hlth & Environm Effects Res Lab, Duluth, MN 55802 USA. [Garcia-Reyero, Natalia] Mississippi State Univ, Gen Biocomp & Biotechnol 1Inst, Starkville, MS 39762 USA. EM edward.j.perkins@usace.army.mil NR 0 TC 0 Z9 0 U1 1 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 7-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165105452 ER PT J AU Peterson, GW DeCoste, JB AF Peterson, Gregory W. DeCoste, Jared B. TI Mesoporosity development in Zr-based metal-organic frameworks via plasma etching SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Peterson, Gregory W.] US Army, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [DeCoste, Jared B.] Leidos Inc, Gundpowder, MD 21010 USA. EM gregory.w.peterson.civ@mail.mil NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 442-INOR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8KC UT WOS:000349167401105 ER PT J AU Schroeder, A Ankley, G Berninger, J LaLone, C Cavallin, J Durhan, E Eid, E Garcia-Reyero, N Hughes, M Jensen, K Kahl, M Makynen, E Perkins, E Stevens, K Villeneuve, D AF Schroeder, Anthony Ankley, Gerald Berninger, Jason LaLone, Carlie Cavallin, Jenna Durhan, Elizabeth Eid, Evan Garcia-Reyero, Natalia Hughes, Megan Jensen, Kathy Kahl, Michael Makynen, Elizabeth Perkins, Ed Stevens, Kyle Villeneuve, Dan TI Integration of analytical and biological measurements for assessing the effects of contaminants present at Great Lakes areas of concern SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Schroeder, Anthony; LaLone, Carlie] Univ Minnesota, Water Resources Ctr, St Paul, MN 55108 USA. [Schroeder, Anthony; Ankley, Gerald; LaLone, Carlie; Durhan, Elizabeth; Eid, Evan; Hughes, Megan; Jensen, Kathy; Kahl, Michael; Makynen, Elizabeth; Villeneuve, Dan] US EPA, Midcontinent Ecol Div, Duluth, MN 55804 USA. [Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS USA. [Perkins, Ed] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. EM schroeder.anthony@epa.gov RI Berninger, Jason/O-2401-2016 OI Berninger, Jason/0000-0003-3045-7899 NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 668-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165106211 ER PT J AU Siraj, N Das, S Hasan, FS Kiruri, LW Gall, KES Warner, IM AF Siraj, Noureen Das, Susmita Hasan, Farhana S. Kiruri, Lucy W. Gall, Karen E. Steege Warner, Isiah M. TI Anomalous S-2 emission from carbazole-based GUMBOS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Siraj, Noureen; Das, Susmita; Hasan, Farhana S.; Kiruri, Lucy W.; Warner, Isiah M.] Louisiana State Univ, Baton Rouge, LA 70803 USA. [Gall, Karen E. Steege] USA, HORIBA Sci, Philadelphia, PA 08820 USA. EM nsiraj@lsu.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 61-PHYS PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8KC UT WOS:000349167403666 ER PT J AU Thompson, T Wolfenstine, J Allen, J Johannes, M Huq, A Sakamoto, J AF Thompson, Travis Wolfenstine, Jeff Allen, Jan Johannes, Michelle Huq, Ashfia Sakamoto, Jeff TI Tetragonal vs. cubic phase stability in Al - free Ta doped Li7La3Zr2O12 garnet Li ion solid electrolyte SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Thompson, Travis; Sakamoto, Jeff] Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA. [Wolfenstine, Jeff; Allen, Jan] Army Res Lab, RDRL SED C, Adelphi, MD 20783 USA. [Johannes, Michelle] Naval Res Lab, Ctr Computat Mat Sci, Anacostia, VA USA. [Huq, Ashfia] Oak Ridge Natl Lab, Spallat Neutron Source, Oak Ridge, TN USA. EM trthompson378@gmail.com NR 0 TC 0 Z9 0 U1 2 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 561-ENFL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165105368 ER PT J AU Torres, OB Jalah, R Rice, KC Li, FY Antoline, JFG Iyer, MR Cheng, KJ Jacobson, AE Beck, Z Alving, CR Matyas, GR AF Torres, Oscar B. Jalah, Rashmi Rice, Kenner C. Li, Fuying Antoline, Joshua F. G. Iyer, Malliga R. Cheng, Kejun Jacobson, Arthur E. Beck, Zoltan Alving, Carl R. Matyas, Gary R. TI Development of a vaccine for the treatment of heroin addiction: Determination of the optimal heroin hapten-carrier density SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Torres, Oscar B.; Jalah, Rashmi; Beck, Zoltan; Alving, Carl R.; Matyas, Gary R.] US Mil HIV Res Program, Walter Reed Army Inst Res, Lab Adjuvant & Antigen Res, Silver Spring, MD 20910 USA. [Rice, Kenner C.; Li, Fuying; Antoline, Joshua F. G.; Cheng, Kejun; Jacobson, Arthur E.] NIDA, Dept Hlth & Human Serv, Drug Design & Synth Sect, Chem Biol Res Branch, Bethesda, MD 20892 USA. [Rice, Kenner C.; Li, Fuying; Antoline, Joshua F. G.; Iyer, Malliga R.; Cheng, Kejun; Jacobson, Arthur E.] NIAAA, NIH, Bethesda, MD 20892 USA. [Torres, Oscar B.; Jalah, Rashmi; Beck, Zoltan] US Mil HIV Res Program, Henry M Jackson Fdn Adv Mil Med, Bethesda, MD 20817 USA. EM otorres@hivresearch.org NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 428-MEDI PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8KC UT WOS:000349167402224 ER PT J AU Tran, DT Rong, C AF Tran, Dat T. Rong, Charles TI Desulfurization of H2S using porous ZnO-based materials as sorbents SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Tran, Dat T.; Rong, Charles] US Army Res Lab, Sensor & Electron Devices Directorate, Adelphi, MD 20783 USA. EM dat.t.tran4.civ@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 306-ENFL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165105144 ER PT J AU Taylor, DE AF Taylor, DeCarlos E. TI Pressure dependent elastic constants of alpha and gamma cyclotrimethylene trinitramine: A quantum mechanical study SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID SOLID NITROMETHANE; CRYSTAL-STRUCTURE; MONTE-CARLO; RDX; SIMULATIONS; STRAIN; HMX AB The elastic constants of the alpha and gamma polymorphs of cyclotrimethylene trinitramine (RDX) have been computed using dispersion corrected density functional theory (DFT). The DFT results validate the values obtained in several experiments using ultrasonic and impulsive stimulated thermal scattering techniques and disagree with those obtained using Brillouin scattering which, in general, exceed the other experimental and theoretical results. Compressibility diagrams at zero pressure are presented for the ab, ac, and bc crystallographic planes, and the anisotropic linear compressibility within the ac plane of alpha-RDX at 0 GPa, observed using ultrasonic and impulsive stimulated thermal scattering measurements, is verified using DFT. The pressure dependence of the elastic constants of alpha-RDX (0-4 GPa) and gamma-RDX (4-8 GPa) is also presented. C1 US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Taylor, DE (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM decarlos.e.taylor.civ@mail.mil NR 29 TC 8 Z9 8 U1 2 U2 22 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD AUG 7 PY 2014 VL 116 IS 5 AR 053513 DI 10.1063/1.4891999 PG 9 WC Physics, Applied SC Physics GA AO2TM UT WOS:000341178900021 ER PT J AU Whitney, JB Hill, AL Sanisetty, S Penaloza-MacMaster, P Liu, JY Shetty, M Parenteau, L Cabral, C Shields, J Blackmore, S Smith, JY Brinkman, AL Peter, LE Mathew, SI Smith, KM Borducchi, EN Rosenbloom, DIS Lewis, MG Hattersley, J Li, B Hesselgesser, J Geleziunas, R Robb, ML Kim, JH Michael, NL Barouch, DH AF Whitney, James B. Hill, Alison L. Sanisetty, Srisowmya Penaloza-MacMaster, Pablo Liu, Jinyan Shetty, Mayuri Parenteau, Lily Cabral, Crystal Shields, Jennifer Blackmore, Stephen Smith, Jeffrey Y. Brinkman, Amanda L. Peter, Lauren E. Mathew, Sheeba I. Smith, Kaitlin M. Borducchi, Erica N. Rosenbloom, Daniel I. S. Lewis, Mark G. Hattersley, Jillian Li, Bei Hesselgesser, Joseph Geleziunas, Romas Robb, Merlin L. Kim, Jerome H. Michael, Nelson L. Barouch, Dan H. TI Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys SO NATURE LA English DT Article ID IMMUNODEFICIENCY VIRUS-INFECTION; ACTIVE ANTIRETROVIRAL THERAPY; HIV-1 INFECTION; LATENT INFECTION; REPLICATION; VACCINE; PREVENTION; INITIATION; DYNAMICS; DEPENDS AB The viral reservoir represents a critical challenge for human immunodeficiency virus type 1 (HIV-1) eradication strategies(1-5). However, it remains unclear when and where the viral reservoir is seeded during acute infection and the extent to which it is susceptible to early anti-retroviral therapy (ART). Here we show that the viral reservoir is seeded rapidly after mucosal simian immunodeficiency virus (SIV) infection of rhesus monkeys and before systemic viraemia. We initiated suppressive ART in groups of monkeys on days 3, 7, 10 and 14 after intrarectal SIVMAC251 infection. Treatment with ART on day 3 blocked the emergence of viral RNA and proviral DNA in peripheral blood and also substantially reduced levels of proviral DNA in lymph nodes and gastrointestinal mucosa as compared with treatment at later time points. In addition, treatment on day 3 abrogated the induction of SIV-specific humoral and cellular immune responses. Nevertheless, after discontinuation of ART following 24 weeks of fully suppressive therapy, virus rebounded in all animals, although the monkeys that were treated on day 3 exhibited a delayed viral rebound as compared with those treated on days 7, 10 and 14. The time to viral rebound correlated with total viraemia during acute infection and with proviral DNA at the time of ART discontinuation. These data demonstrate that the viral reservoir is seeded rapidly after intrarectal SIV infection of rhesus monkeys, during the 'eclipse' phase, and before detectable viraemia. This strikingly early seeding of the refractory viral reservoir raises important new challenges for HIV-1 eradication strategies. C1 [Whitney, James B.; Sanisetty, Srisowmya; Penaloza-MacMaster, Pablo; Liu, Jinyan; Shetty, Mayuri; Parenteau, Lily; Cabral, Crystal; Shields, Jennifer; Blackmore, Stephen; Smith, Jeffrey Y.; Brinkman, Amanda L.; Peter, Lauren E.; Mathew, Sheeba I.; Smith, Kaitlin M.; Borducchi, Erica N.; Barouch, Dan H.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Ctr Virol & Vaccine Res, Boston, MA 02215 USA. [Whitney, James B.; Barouch, Dan H.] Ragon Inst MGH MIT & Harvard, Cambridge, MA 02139 USA. [Hill, Alison L.; Rosenbloom, Daniel I. S.] Harvard Univ, Program Evolutionary Dynam, Cambridge, MA 02138 USA. [Lewis, Mark G.] Bioqual, Rockville, MD 20852 USA. [Hattersley, Jillian; Li, Bei; Hesselgesser, Joseph; Geleziunas, Romas] Gilead Sci Inc, Foster City, CA 94404 USA. [Robb, Merlin L.; Kim, Jerome H.; Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. RP Barouch, DH (reprint author), Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Ctr Virol & Vaccine Res, Boston, MA 02215 USA. EM dbarouch@bidmc.harvard.edu FU US Army Medical Research and Material Command; US Military HIV Research Program; Henry M. Jackson Foundation for the Advancement of Military Medicine [W81XWH-07-2-0067, W81XWH-11-2-0174]; NIH [AI060354, AI078526, AI084794, AI095985, AI096040, AI100645]; Ragon Institute of MGH, MIT and Harvard FX We thank M. Pensiero, M. Marovich, C. Dieffenbach, W. Wagner, C. Gittens, J. Yalley-Ogunro, M. Nowak, R. Siliciano, D. Persaud, S. Deeks, N. Chomont, J. Ananworanich, L. Picker, F. Stephens, R. Hamel, K. Kelly and L. Dunne for advice, assistance and reagents. The SIVMAC239 peptides were obtained from the National Institutes of Health (NIH) AIDS Research and Reference Reagent Program. We acknowledge support from the US Army Medical Research and Material Command and the US Military HIV Research Program through its cooperative agreement with the Henry M. Jackson Foundation for the Advancement of Military Medicine (W81XWH-07-2-0067, W81XWH-11-2-0174); the NIH (AI060354, AI078526, AI084794, AI095985, AI096040, AI100645); and the Ragon Institute of MGH, MIT and Harvard. The views expressed in this manuscript are those of the authors and do not represent the official views of the Department of the Army or the Department of Defense. NR 28 TC 128 Z9 132 U1 6 U2 27 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0028-0836 EI 1476-4687 J9 NATURE JI Nature PD AUG 7 PY 2014 VL 512 IS 7512 BP 74 EP + DI 10.1038/nature13594 PG 15 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AM5NX UT WOS:000339908000034 PM 25042999 ER PT J AU Bozue, J Cote, CK Chance, T Kugelman, J Kern, SJ Kijek, TK Jenkins, A Mou, S Moody, K Fritz, D Robinson, CG Bell, T Worsham, P AF Bozue, Joel Cote, Christopher K. Chance, Taylor Kugelman, Jeffrey Kern, Steven J. Kijek, Todd K. Jenkins, Amy Mou, Sherry Moody, Krishna Fritz, David Robinson, Camenzind G. Bell, Todd Worsham, Patricia TI A Yersinia pestis tat Mutant Is Attenuated in Bubonic and Small-Aerosol Pneumonic Challenge Models of Infection but Not As Attenuated by Intranasal Challenge SO PLOS ONE LA English DT Article ID ARGININE TRANSLOCATION SYSTEM; PROTEIN-TRANSPORT SYSTEM; ESCHERICHIA-COLI; SIGNAL PEPTIDE; V-ANTIGEN; PLASMINOGEN-ACTIVATOR; PSEUDOMONAS-SYRINGAE; REGULATORY PROTEIN; BIOFILM FORMATION; PLAGUE VACCINE AB Bacterial proteins destined for the Tat pathway are folded before crossing the inner membrane and are typically identified by an N-terminal signal peptide containing a twin arginine motif. Translocation by the Tat pathway is dependent on the products of genes which encode proteins possessing the binding site of the signal peptide and mediating the actual translocation event. In the fully virulent CO92 strain of Yersinia pestis, the tatA gene was deleted. The mutant was assayed for loss of virulence through various in vitro and in vivo assays. Deletion of the tatA gene resulted in several consequences for the mutant as compared to wild-type. Cell morphology of the mutant bacteria was altered and demonstrated a more elongated form. In addition, while cultures of the mutant strain were able to produce a biofilm, we observed a loss of adhesion of the mutant biofilm structure compared to the biofilm produced by the wild-type strain. Immuno-electron microscopy revealed a partial disruption of the F1 antigen on the surface of the mutant. The virulence of the Delta tatA mutant was assessed in various murine models of plague. The mutant was severely attenuated in the bubonic model with full virulence restored by complementation with the native gene. After small-particle aerosol challenge in a pneumonic model of infection, the mutant was also shown to be attenuated. In contrast, when mice were challenged intranasally with the mutant, very little difference in the LD50 was observed between wild-type and mutant strains. However, an increased time-to- death and delay in bacterial dissemination was observed in mice infected with the Delta tatA mutant as compared to the parent strain. Collectively, these findings demonstrate an essential role for the Tat pathway in the virulence of Y. pestis in bubonic and small-aerosol pneumonic infection but less important role for intranasal challenge. C1 [Bozue, Joel; Cote, Christopher K.; Kijek, Todd K.; Jenkins, Amy; Mou, Sherry; Moody, Krishna; Fritz, David; Worsham, Patricia] US Army, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. [Chance, Taylor; Robinson, Camenzind G.; Bell, Todd] US Army, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. [Kugelman, Jeffrey] US Army, Med Res Inst Infect Dis, Ctr Genome Sci, Ft Detrick, MD 21702 USA. [Kern, Steven J.] US Army, Med Res Inst Infect Dis, Off Res Support, Ft Detrick, MD 21702 USA. RP Bozue, J (reprint author), US Army, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. EM joel.a.bozue@us.army.mil FU Defense Threat Reduction Agency JSTO-CBD [923698] FX The research described herein was sponsored by the Defense Threat Reduction Agency JSTO-CBD (project number 923698). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 94 TC 0 Z9 0 U1 0 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD AUG 7 PY 2014 VL 9 IS 8 AR e104524 DI 10.1371/journal.pone.0104524 PG 18 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AM6SB UT WOS:000339993900072 PM 25101850 ER PT J AU Rhon, DI Boyles, RB Cleland, JA AF Rhon, Daniel I. Boyles, Robert B. Cleland, Joshua A. TI One-Year Outcome of Subacromial Corticosteroid Injection Compared With Manual Physical Therapy for the Management of the Unilateral Shoulder Impingement Syndrome SO ANNALS OF INTERNAL MEDICINE LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; PAIN INTENSITY MEASUREMENT; ROTATOR CUFF TENDINITIS; FEAR-AVOIDANCE BELIEFS; QUALITY-OF-LIFE; GENERAL-PRACTICE; PRIMARY-CARE; CLINICAL-TRIAL; PATIENT CHARACTERISTICS; MANIPULATIVE THERAPY AB Background: Corticosteroid injections (CSIs) and physical therapy are used to treat patients with the shoulder impingement syndrome (SIS) but have never been directly compared. Objective: To compare the effectiveness of 2 common nonsurgical treatments for SIS. Design: Randomized, single-blind, comparative-effectiveness, parallel-group trial. (ClinicalTrials.gov: NCT01190891) Setting: Military hospital-based outpatient clinic in the United States. Patients: 104 patients aged 18 to 65 years with unilateral SIS between June 2010 and March 2012. Intervention: Random assignment into 2 groups: 40-mg triamcinolone acetonide subacromial CSI versus 6 sessions of manual physical therapy. Measurements: The primary outcome was change in Shoulder Pain and Disability Index scores at 1 year. Secondary outcomes included the Global Rating of Change scores, the Numeric Pain Rating Scale scores, and 1-year health care use. Results: Both groups demonstrated approximately 50% improvement in Shoulder Pain and Disability Index scores maintained through 1 year; however, the mean difference between groups was not significant (1.5% [95% CI, -6.3% to 9.4%]). Both groups showed improvements in Global Rating of Change scale and pain rating scores, but between-group differences in scores for the Global Rating of Change scale (0 [CI, -2 to 1]) and pain rating (0.4 [CI, -0.5 to 1.2]) were not significant. During the 1-year follow-up, patients receiving CSI had more SIS-related visits to their primary care provider (60% vs. 37%) and required additional steroid injections (38% vs. 20%), and 19% needed physical therapy. Transient pain from the CSI was the only adverse event reported. Limitation: The study occurred at 1 center with patients referred to physical therapy. Conclusion: Both groups experienced significant improvement. The manual physical therapy group used less 1-year SIS-related health care resources than the CSI group. C1 Madigan Army Med, Tacoma, WA USA. Univ Puget Sound, Tacoma, WA 98416 USA. Franklin Pierce Univ, Manchester, NH USA. RP Rhon, DI (reprint author), Brooke Army Med Ctr, Ctr Intrepid, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. FU Cardon Rehabilitation Products through the American Academy of Orthopaedic Manual Physical Therapists FX Primary Funding Source: Cardon Rehabilitation Products through the American Academy of Orthopaedic Manual Physical Therapists. NR 74 TC 18 Z9 18 U1 4 U2 17 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 USA SN 0003-4819 EI 1539-3704 J9 ANN INTERN MED JI Ann. Intern. Med. PD AUG 5 PY 2014 VL 161 IS 3 BP 161 EP U108 DI 10.7326/M13-2199 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA AN3KH UT WOS:000340486000001 PM 25089860 ER PT J AU West, AL Griep, MH Cole, DP Karna, SP AF West, Abby L. Griep, Mark H. Cole, Daniel P. Karna, Shashi P. TI DNase 1 Retains Endodeoxyribonuclease Activity Following Gold Nanocluster Synthesis SO ANALYTICAL CHEMISTRY LA English DT Article ID REAL-TIME PCR; HIGHLY FLUORESCENT; DIRECTED SYNTHESIS; QUANTUM DOTS; CONTAMINATION; SAMPLES; AGENTS; GLUTATHIONE; CLUSTERS AB Here we present the synthesis of the enzyme DNase 1 stabilized gold nanoclusters (DNase 1:AuNCs) with core size consisting of either 8 or 25 atoms. The DNase 1:Au8NCs exhibit blue fluorescence whereas the DNase 1:Au25NCs are red emitting. In addition to the intense fluorescence emission, the synthesized DNase 1:AuNC hybrid retains the native functionality of the protein, allowing simultaneous detection and digestion of DNA with a detection limit of 2 mu g/mL. The DNase 1:AuNCs could be conveniently employed as efficient and fast sensors to augment the current time-consuming DNA contamination analysis techniques. C1 [West, Abby L.; Griep, Mark H.; Karna, Shashi P.] US Army Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen, MD 21005 USA. [Cole, Daniel P.] US Army Res Lab, Vehicle Technol Directorate, ATTN RDRL VT, Aberdeen, MD 21005 USA. RP West, AL (reprint author), US Army Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, 4600 Deer Creek Loop, Aberdeen, MD 21005 USA. EM abby.west2.ctr@mail.mil FU Maryland NanoCenter; NispLab; U.S. Army Research Laboratory [NNL09AA00A] FX The authors thank V. Rodriguez Santiago for the X-ray photoelectron spectroscopy. For transmission electron microscopy (TEM) analysis, we acknowledge the support of the Maryland NanoCenter and its NispLab. The NispLab is supported in part by the NSF as a MRSEC Shared Experimental Facility. The authors also thank M. Sellers and J. Martin for aid and input on this work. A. West acknowledges the receipt of an ARL-ORAU Postdoctoral Associateship. D.P.C. is a contractor to the U.S. Army Research Laboratory under contract NNL09AA00A. NR 27 TC 12 Z9 12 U1 5 U2 72 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 EI 1520-6882 J9 ANAL CHEM JI Anal. Chem. PD AUG 5 PY 2014 VL 86 IS 15 BP 7377 EP 7382 DI 10.1021/ac5005794 PG 6 WC Chemistry, Analytical SC Chemistry GA AM7XD UT WOS:000340081100035 PM 24999001 ER PT J AU Pamplin, JC Cancio, LC AF Pamplin, Jeremy C. Cancio, Leopoldo C. TI The Power of Suggestion SO RESPIRATORY CARE LA English DT Editorial Material C1 [Pamplin, Jeremy C.; Cancio, Leopoldo C.] US Army Inst Surg Res, Joint Base San Antonio, Ft Sam Houston, TX 78234 USA. RP Pamplin, JC (reprint author), US Army Inst Surg Res, Joint Base San Antonio, Ft Sam Houston, TX 78234 USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU DAEDALUS ENTERPRISES INC PI IRVING PA 9425 N MAC ARTHUR BLVD, STE 100, IRVING, TX 75063-4706 USA SN 0020-1324 EI 1943-3654 J9 RESP CARE JI Respir. Care PD AUG PY 2014 VL 59 IS 8 BP 1310 EP 1311 DI 10.4187/respcare.03498 PG 2 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA CA8VV UT WOS:000349199900020 PM 25233519 ER PT J AU Zaghloul, AI Bird, TS Bernhard, JT AF Zaghloul, Amir I. Bird, Trevor S. Bernhard, Jennifer T. TI Guest Editorial Special Issue on Antenna Design and Integration in Smart Sensors SO IEEE SENSORS JOURNAL LA English DT Editorial Material C1 [Zaghloul, Amir I.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Zaghloul, Amir I.] Virginia Tech, Dept Elect & Comp Engn, Blacksburg, VA 24061 USA. [Bird, Trevor S.] Macquarie Univ, Dept Engn, Sydney, NSW 2109, Australia. [Bernhard, Jennifer T.] Univ Illinois, Dept Elect & Comp Engn, Urbana, IL 61801 USA. RP Zaghloul, AI (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. EM amir.i.zaghloul.civ@mail.mil; ts.bird@ieee.org; jbernhar@illinois.edu OI Bernhard, Jennifer/0000-0002-0929-387X NR 0 TC 0 Z9 0 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1530-437X EI 1558-1748 J9 IEEE SENS J JI IEEE Sens. J. PD AUG PY 2014 VL 14 IS 8 BP 2405 EP 2405 DI 10.1109/JSEN.2014.2333571 PG 1 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA AY0XL UT WOS:000347317600001 ER PT J AU Lesho, EP Waterman, PE Chukwuma, U McAuliffe, K Neumann, C Julius, MD Crouch, H Chandrasekera, R English, JF Clifford, RJ Kester, KE AF Lesho, Emil P. Waterman, Paige E. Chukwuma, Uzo McAuliffe, Kathryn Neumann, Charlotte Julius, Michael D. Crouch, Helen Chandrasekera, Ruvani English, Judith F. Clifford, Robert J. Kester, Kent E. TI The Antimicrobial Resistance Monitoring and Research (ARMoR) Program: The US Department of Defense Response to Escalating Antimicrobial Resistance SO CLINICAL INFECTIOUS DISEASES LA English DT Editorial Material DE antimicrobial resistance; surveillance; infection prevention; Department of Defense ID METALLO-BETA-LACTAMASE; STAPHYLOCOCCUS-AUREUS; PROVIDENCIA-STUARTII; ACINETOBACTER-BAUMANNII; SURVEILLANCE NETWORK; CLINICAL ISOLATE; UNITED-STATES; BLA(NDM-1); SEQUENCE; EPIDEMIOLOGY AB Responding to escalating antimicrobial resistance (AMR), the US Department of Defense implemented an enterprise-wide collaboration, the Antimicrobial Resistance Monitoring and Research Program, to aid in infection prevention and control. It consists of a network of epidemiologists, bioinformaticists, microbiology researchers, policy makers, hospital-based infection preventionists, and healthcare providers who collaborate to collect relevant AMR data, conduct centralized molecular characterization, and use AMR characterization feedback to implement appropriate infection prevention and control measures and influence policy. A particularly concerning type of AMR, carbapenem-resistant Enterobacteriaceae, significantly declined after the program was launched. Similarly, there have been no further reports or outbreaks of another concerning type of AMR, colistin resistance in Acinetobacter, in the Department of Defense since the program was initiated. However, bacteria containing AMR-encoding genes are increasing. To update program stakeholders and other healthcare systems facing such challenges, we describe the processes and impact of the program. C1 [Lesho, Emil P.; Waterman, Paige E.; Julius, Michael D.; Clifford, Robert J.] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD USA. [Waterman, Paige E.; Chandrasekera, Ruvani] Global Emerging Infect Surveillance & Response Sy, Armed Forces Hlth Surveillance Ctr, Silver Spring, MD USA. [Lesho, Emil P.; Waterman, Paige E.; Kester, Kent E.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. [Chukwuma, Uzo; McAuliffe, Kathryn; Neumann, Charlotte] Navy & Marine Corps Publ Hlth, EpiData Ctr Dept, Portsmouth, VA USA. [Crouch, Helen] Brooke Army Med Ctr, San Antonio, TX USA. [English, Judith F.] Navy Bur Med & Surg, Falls Church, VA USA. RP Lesho, EP (reprint author), 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM p.lesho.mil@mail.mil OI Chandrasekera, Ruvani/0000-0002-6251-2154 NR 33 TC 14 Z9 14 U1 1 U2 6 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD AUG 1 PY 2014 VL 59 IS 3 BP 390 EP 397 DI 10.1093/cid/ciu319 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AQ6KG UT WOS:000342919700011 PM 24795331 ER PT J AU Webster, MA Rigor, IG Nghiem, SV Kurtz, NT Farrell, SL Perovich, DK Sturm, M AF Webster, Melinda A. Rigor, Ignatius G. Nghiem, Son V. Kurtz, Nathan T. Farrell, Sinead L. Perovich, Donald K. Sturm, Matthew TI Interdecadal changes in snow depth on Arctic sea ice SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID THERMAL-CONDUCTIVITY; THICKNESS; PRODUCTS AB Snow plays a key role in the growth and decay of Arctic sea ice. In winter, it insulates sea ice from cold air temperatures, slowing sea ice growth. From spring to summer, the albedo of snow determines how much insolation is absorbed by the sea ice and underlying ocean, impacting ice melt processes. Knowledge of the contemporary snow depth distribution is essential for estimating sea ice thickness and volume, and for understanding and modeling sea ice thermodynamics in the changing Arctic. This study assesses spring snow depth distribution on Arctic sea ice using airborne radar observations from Operation IceBridge for 2009-2013. Data were validated using coordinated in situ measurements taken in March 2012 during the Bromine, Ozone, and Mercury Experiment (BROMEX) field campaign. We find a correlation of 0.59 and root-mean-square error of 5.8 cm between the airborne and in situ data. Using this relationship and Ice-Bridge snow thickness products, we compared the recent results with data from the 1937, 1954-1991 Soviet drifting ice stations. The comparison shows thinning of the snowpack, from 35.1 +/- 9.4 to 22.2 +/- 1.9 cm in the western Arctic, and from 32.8 +/- 9.4 to 14.5 +/- 1.9 cm in the Beaufort and Chukchi seas. These changes suggest a snow depth decline of 37 +/- 29% in the western Arctic and 56 +/- 33% in the Beaufort and Chukchi seas. Thinning is negatively correlated with the delayed onset of sea ice freezeup during autumn. C1 [Webster, Melinda A.; Rigor, Ignatius G.] Univ Washington, Appl Phys Lab, Polar Sci Ctr, Seattle, WA 98105 USA. [Nghiem, Son V.] CALTECH, Jet Prop Lab, Pasadena, CA USA. [Kurtz, Nathan T.; Farrell, Sinead L.] NASA, Goddard Space Flight Ctr, Hydrospher & Biospher Sci Lab, Greenbelt, MD 20771 USA. [Farrell, Sinead L.] Univ Maryland, Earth Syst Sci Interdisciplinary Ctr, College Pk, MD 20742 USA. [Perovich, Donald K.] US Army Corps Engineers, Engn Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH USA. [Sturm, Matthew] Univ Alaska Fairbanks, Inst Geophys, Fairbanks, AK 99775 USA. RP Webster, MA (reprint author), Univ Washington, Appl Phys Lab, Polar Sci Ctr, Seattle, WA 98105 USA. EM melindaw@uw.edu RI Farrell, Sinead/F-5586-2010 OI Farrell, Sinead/0000-0003-3222-2751 FU NASA Cryospheric Sciences Program FX Snow data from the 2012 BROMEX field campaign are available upon request. Meteorological data are available at http://www.esrl.noaa.gov/gmd/dv/. The IceBridge quick-look and standard snow depth products are available at https://nsidc.org/data/docs /daac/icebridge/evaluation_products/sea-ice-freeboard-snowdepththickness -quicklook-index.html and http://nsidc. org/data/idcsi2.html. The Soviet station snow data are available at http://dx.doi.org/10.7265/N5MS3QNJ. Ice Mass Balance buoy data are available at http://IMB.crrel.usace.army.mil. The sea ice freezeup product from passive microwave satellite data is available at http://neptune.gsfc.nasa.gov/csb/index.php? section=54. This research was supported by the National Aeronautics and Space Administration (NASA), and by contributors to the U.S. Interagency Arctic Buoy Program, which include the U.S. Coast Guard, NAVO, NIC, NOAA, NSF, and ONR. This is JISAO contribution 2225. The research carried out at the Jet Propulsion Laboratory, California Institute of Technology, was supported by the NASA Cryospheric Sciences Program. We thank Jacqueline A. Richter-Menge of the U.S. Army Cold Regions Research and Engineering Laboratory for the planning and coordination of the IceBridge flight operation with the BROMEX field campaign, and Stephen Warren for helpful discussions. We thank UMIAQ, the Barrow whaling community, and the Barrow Arctic Science Consortium for their assistance in the BROMEX field campaign. NR 42 TC 27 Z9 28 U1 4 U2 29 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-9275 EI 2169-9291 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD AUG PY 2014 VL 119 IS 8 BP 5395 EP 5406 DI 10.1002/2014JC009985 PG 12 WC Oceanography SC Oceanography GA AQ1CR UT WOS:000342519500039 ER PT J AU Hoge, CW Warner, CH Castro, CA AF Hoge, Charles W. Warner, Christopher H. Castro, Carl A. TI Mental Health and the Army SO JAMA PSYCHIATRY LA English DT Letter ID ASSESS RISK; RESILIENCE; SOLDIERS; STARRS; PREVALENCE; BEHAVIOR; SUICIDE C1 [Hoge, Charles W.] Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Warner, Christopher H.] 101st Airborne Div, Ft Campbell, KY USA. [Castro, Carl A.] Univ So Calif, Sch Social Work, Los Angeles, CA 90089 USA. RP Hoge, CW (reprint author), Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD 20910 USA. EM charles.hoge@us.army.mil NR 9 TC 5 Z9 5 U1 2 U2 4 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-622X EI 2168-6238 J9 JAMA PSYCHIAT JI JAMA Psychiatry PD AUG PY 2014 VL 71 IS 8 BP 965 EP 966 PG 2 WC Psychiatry SC Psychiatry GA AP0SP UT WOS:000341774600016 PM 25102900 ER PT J AU Hackman, RM Aggarwal, BB Applebaum, RS White, RWD Dubick, MA Heber, D Ito, T Johnson, GH Keen, CL Winters, BL Stohs, SJ AF Hackman, Robert M. Aggarwal, Bharat B. Applebaum, Rhona S. White, Ralph W. deVere Dubick, Michael A. Heber, David Ito, Toshinori Johnson, Guy H. Keen, Carl L. Winters, Barbara L. Stohs, Sidney J. TI Forecasting Nutrition Research in 2020 SO JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION LA English DT Editorial Material DE clinical nutrition; obesity; microbiome; gene expression; nutrition education; public health ID PROCESSED FOODS; OBESITY; HEALTH; CANCER; ADULTS C1 [Hackman, Robert M.; Keen, Carl L.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA. [Keen, Carl L.] Univ Calif Davis, Dept Internal Med, Davis, CA 95616 USA. [Aggarwal, Bharat B.] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA. [Applebaum, Rhona S.] Coca Cola Co, Atlanta, GA USA. [White, Ralph W. deVere] Dept Urol, Sacramento, CA USA. [White, Ralph W. deVere] UC Davis Comprehens Canc Ctr, Sacramento, CA USA. [Dubick, Michael A.] US Army, Inst Surg Res, San Antonio, TX USA. [Heber, David] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA. [Heber, David] Univ Calif Los Angeles, Dept Publ Hlth, Los Angeles, CA USA. [Ito, Toshinori] Osaka Univ, Grad Sch Med, Dept Complementary & Alternat Med, Osaka, Japan. [Johnson, Guy H.] Nutr Solut Inc, Minneapolis, MN USA. [Winters, Barbara L.] Campbell Soup Co, Camden, NJ USA. [Stohs, Sidney J.] Creighton Univ, Sch Pharm & Hlth Profess, Omaha, NE 68178 USA. RP Hackman, RM (reprint author), Univ Calif Davis, Dept Nutr, 1 Shields Ave,3135 Meyer Hall, Davis, CA 95616 USA. EM rmhackman@ucdavis.edu RI Aggarwal, Bharat/G-3388-2013 NR 32 TC 1 Z9 1 U1 0 U2 13 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0731-5724 EI 1541-1087 J9 J AM COLL NUTR JI J. Am. Coll. Nutr. PD AUG PY 2014 VL 33 IS 4 BP 340 EP 346 DI 10.1080/07315724.2014.943113 PG 7 WC Nutrition & Dietetics SC Nutrition & Dietetics GA AP5SV UT WOS:000342139900010 PM 25144361 ER PT J AU Blackburn, JK Skrypnyk, A Bagamian, KH Nikolich, MP Bezymennyi, M Skrypnyk, V AF Blackburn, Jason K. Skrypnyk, Artem Bagamian, Karoun H. Nikolich, Mikeljon P. Bezymennyi, Maksym Skrypnyk, Valeriy TI Anthrax in a Backyard Domestic Dog in Ukraine: A Case Report SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Dogs; Anthrax; Bacillus anthracis; Ukraine; Surveillance ID NATIONAL-PARK AB Anthrax has been reported in domestic and wild dogs throughout much of the world. Generally, canids are considered resistant to anthrax, although there are several reports of anthrax deaths in both wild and domestic canid populations. Prior to 2012, anthrax had not been reported in dogs in Ukraine, despite a long history in livestock and wildlife. An outbreak involving at least one cow and one dog was reported from a backyard setting in southern Ukraine in August of 2012. Laboratory results and epizootic data were compiled from official investigation reports of regional and state veterinary services involved in the case response. A single dog died after being fed meat and bones from an illegally slaughtered heifer that died of anthrax 5 days earlier. On the evening of the dog's death, the dog refused food or water; however, there were no other clinical signs. Laboratory tests of dog tissue included traditional bacteriology for Bacillus anthracis, a small rodent bioassay for virulence, and immunoprecipitation tests (IPT). IPT was positive, viable B. anthracis colonies were cultured, and a bioassay confirmed virulence. This was the first confirmed case of canid anthrax in Ukraine. This case report serves to remind veterinary officials that anthrax can affect a wide number of species. We advise surveillance systems remain flexible and include animals that might not otherwise be tested. C1 [Blackburn, Jason K.; Bagamian, Karoun H.] Univ Florida, Dept Geog, Spatial Epidemiol & Ecol Res Lab, Gainesville, FL 32611 USA. [Blackburn, Jason K.; Bagamian, Karoun H.] Univ Florida, Emerging Pathogens Inst, Gainesville, FL 32611 USA. [Skrypnyk, Artem] Black & Veatch Special Projects Corp, Kiev, Ukraine. [Nikolich, Mikeljon P.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Bezymennyi, Maksym; Skrypnyk, Valeriy] State Sci Control Inst Biotechnol & Strains Micro, Kiev, Ukraine. RP Blackburn, JK (reprint author), Univ Florida, Dept Geog, Spatial Epidemiol & Ecol Res Lab, 3141 Turlington Hall, Gainesville, FL 32611 USA. EM jkblackburn@ufl.edu FU US Defense Threat Reduction Agency's (DTRA) Cooperative Biological Engagement Program in Ukraine under the UP-2 Project FX This case study was funded by the US Defense Threat Reduction Agency's (DTRA) Cooperative Biological Engagement Program in Ukraine under the UP-2 Project. G. Glass provided insights and comments that greatly strengthened this manuscript. NR 10 TC 2 Z9 2 U1 1 U2 6 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 EI 1557-7759 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD AUG PY 2014 VL 14 IS 8 BP 615 EP 617 DI 10.1089/vbz.2013.1519 PG 3 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA AP5VM UT WOS:000342146800012 PM 25072993 ER PT J AU De Lorenzo, RA Ward, JA Jordan, BS Hanson, CE AF De Lorenzo, Robert A. Ward, John A. Jordan, Bryan S. Hanson, Chris E. TI Relationships of Intraosseous and Systemic Pressure Waveforms in a Swine Model SO ACADEMIC EMERGENCY MEDICINE LA English DT Article ID BONE-MARROW; BLOOD-PRESSURE; INFUSION AB Background Despite some focus on the use of intraosseous (IO) catheters to obtain laboratory samples, very little is known about the potential for obtaining other forms of clinical data. Largely unstudied is the relationship between IO pressures (IOPs) and systemic hemodynamic pressures such as mean arterial pressure (MAP) and central venous pressures (CVP). Objectives The objective was to explore the relationship between hemodynamic parameters (blood pressures) measured through an IO catheter and intravascular catheters placed in the arterial and central venous circulation. Methods Eight pigs (Sus scrofa) weighing 30 to 45kg were sedated with a short-acting agent, intubated with a cuffed endotracheal tube, and anesthetized with 2% to 3% isoflurane. Intravascular catheters were placed into the femoral or carotid artery and the femoral or jugular vein for MAP and CVP measurements. IO catheters, 15mm for the sternum and 25mm for the long bones, were placed percutaneously into the proximal tibia, proximal femur, proximal humerus, right proximal ulna, and/or sternum. Pressures were recorded during normotension, hypotension, and hypertension. Results Averaged across all eight animals, the means (ranges) for baseline systemic pressures were as follows: MAP=66.5 (55.6 to 76.7) mmHg, tibia IOP=17.4 (9.3 to 34.5) mmHg, femur IOP =18.4 (3.3 to 33.1) mmHg, humerus IOP=15.7 (2.8 to 28.9) mmHg, ulna IOP=16.0 (7.9 to 25.6) mmHg, sternum IOP=5.7 (-0.5 to 47.9) mmHg, and CVP=2.7mmHg (-3.3 to 7.9) mmHg. The best median correlation occurred between femur IOP and mean MAP (r=0.65). The four highest correlations between IOP and MAP were associated with mean femur IOP. Only one IO site had a correlation coefficient over 0.50 for CVP. The long bones tended to correlate better with the MAP and the sternum tended to correlate better with the CVP. Nonlinearity was observed in the actively rising pressure phases, which can be explained by a hysteresis model. Conclusions The relationship between IOP and MAP or CVP is variable by site, with the MAP and CVP tending to be estimated by the femur and sternum, respectively. The relationship to actively rising pressures is nonlinear and a hysteresis model is proposed to explain the phase change. Further experimentation is needed to refine the IOP relationship to the MAP and CVP and assess the potential of these measurements to provide clinically relevant information. C1 [De Lorenzo, Robert A.; Jordan, Bryan S.] US Army Inst Surg Res, Tact Combat Casualty Care Res Program, Ft Sam Houston, TX 78234 USA. [Ward, John A.] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. [Hanson, Chris E.] Dept Def Vet Serv Act, Ft Sam Houston, TX USA. RP De Lorenzo, RA (reprint author), US Army Inst Surg Res, Tact Combat Casualty Care Res Program, Ft Sam Houston, TX 78234 USA. EM robert.a.delorenzo.mil@mail.mil FU Telemedicine and Technology Research Center, Ft. Detrick, MD FX Funding was provided by a grant from the Telemedicine and Technology Research Center, Ft. Detrick, MD. NR 15 TC 0 Z9 0 U1 0 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1069-6563 EI 1553-2712 J9 ACAD EMERG MED JI Acad. Emerg. Med. PD AUG PY 2014 VL 21 IS 8 BP 899 EP 904 DI 10.1111/acem.12432 PG 6 WC Emergency Medicine SC Emergency Medicine GA AO8YC UT WOS:000341640800010 PM 25154326 ER PT J AU Bandera, BC Burgess, P Strode, M Sparks, P Amin, A AF Bandera, Bradley C. Burgess, Pamela Strode, Matthew Sparks, Preston Amin, Asna TI Fatal Ischemic Proctitis in a Patient with a History of an Aortobi-iliac Interposition Graft SO AMERICAN SURGEON LA English DT Article C1 [Bandera, Bradley C.; Burgess, Pamela; Strode, Matthew; Sparks, Preston; Amin, Asna] Dwight D Eisenhower Army Med Ctr, Dept Gen Surg, Ft Gordon, GA USA. RP Bandera, BC (reprint author), Dwight D Eisenhower Army Med Ctr, 300 Hosp Rd, Ft Gordon, GA 30905 USA. EM b.bandera07@comcast.net NR 2 TC 0 Z9 0 U1 0 U2 0 PU SOUTHEASTERN SURGICAL CONGRESS PI CUMMING PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA SN 0003-1348 EI 1555-9823 J9 AM SURGEON JI Am. Surg. PD AUG PY 2014 VL 80 IS 8 BP E234 EP E235 PG 2 WC Surgery SC Surgery GA AP1FL UT WOS:000341812500008 PM 25105378 ER PT J AU Burgess, P Bandera, B Rozelle, C AF Burgess, Pamela Bandera, Bradley Rozelle, Christopher TI Multifocal Glomangioma of the Gallbladder SO AMERICAN SURGEON LA English DT Article ID GLOMUS TUMORS C1 [Burgess, Pamela; Bandera, Bradley; Rozelle, Christopher] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA. RP Burgess, P (reprint author), Dwight D Eisenhower Army Med Ctr, 300 E Hosp Rd, Ft Gordon, GA 30905 USA. EM pamela.l.burgess5.mil@mail.mil NR 4 TC 0 Z9 0 U1 0 U2 0 PU SOUTHEASTERN SURGICAL CONGRESS PI CUMMING PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA SN 0003-1348 EI 1555-9823 J9 AM SURGEON JI Am. Surg. PD AUG PY 2014 VL 80 IS 8 BP E218 EP E220 PG 3 WC Surgery SC Surgery GA AP1FL UT WOS:000341812500002 PM 25105372 ER PT J AU Venditto, VJ Wieczorek, L Molnar, S Teque, F Landucci, G Watson, DS Forthal, D Polonis, VR Levy, JA Szoka, FC AF Venditto, Vincent J. Wieczorek, Lindsay Molnar, Sebastian Teque, Fernando Landucci, Gary Watson, Douglas S. Forthal, Donald Polonis, Victoria R. Levy, Jay A. Szoka, Francis C., Jr. TI Chemically Modified Peptides Based on the Membrane-Proximal External Region of the HIV-1 Envelope Induce High-Titer, Epitope-Specific Nonneutralizing Antibodies in Rabbits SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; BROADLY NEUTRALIZING ANTIBODIES; HUMAN MONOCLONAL-ANTIBODIES; STRUCTURAL BASIS; 2F5-LIKE ANTIBODIES; IMMUNOGEN DESIGN; GP41; VACCINE; CELL; 2F5 AB Broadly neutralizing monoclonal antibodies (bNAbs) 2F5 and 4E10 bind to the membrane proximal external region (MPER) of gp41 and also cross-react with phospholipids. In this study, we investigated if chemical modifications on the MPER adjacent to 2F5 and 4E10 epitopes using mimetics of inflammation-associated posttranslational modifications to induce 2F5- and 4E10-like bNAbs can break tolerance. We synthesized a series of chemically modified peptides spanning the MPER. The serine, threonine, and tyrosine residues in the peptides were modified with sulfate, phosphate, or nitrate moieties and presented in liposomes for rabbit immunizations. All immunizations resulted in high antisera titers directed toward both the modified and unmodified immunogens. Tyrosine modification was observed to significantly suppress antiepitope responses. Sera with strong anti-gp140 titers were purified by affinity chromatography toward the MPER peptide and found to possess a higher affinity toward the MPER than did the bNAbs 2F5 and 4E10. Modest neutralization was observed in the H9 neutralization assay, but neutralization was not observed in the TZM-bl cell or peripheral blood mononuclear cell (PBMC) neutralization assay platforms. Although neutralizing antibodies were not induced by this approach, we conclude that chemical modifications can increase the immune responses to poorly immunogenic antigens, suggesting that chemical modification in an appropriate immunization protocol should be explored further as an HIV-1 vaccine strategy. C1 [Venditto, Vincent J.; Watson, Douglas S.; Szoka, Francis C., Jr.] Univ Calif San Francisco, Sch Pharm, Dept Bioengn, San Francisco, CA 94143 USA. [Venditto, Vincent J.; Watson, Douglas S.; Szoka, Francis C., Jr.] Univ Calif San Francisco, Sch Pharm, Dept Therapeut Sci, San Francisco, CA 94143 USA. [Wieczorek, Lindsay; Molnar, Sebastian; Polonis, Victoria R.] Walter Reed Army Inst Res, Lab Vaccine Immunol, Mil HIV Res Program, Silver Spring, MD USA. [Wieczorek, Lindsay; Molnar, Sebastian] Henry M Jackson Fdn, Bethesda, MD USA. [Teque, Fernando; Levy, Jay A.] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA. [Landucci, Gary; Forthal, Donald] Univ Calif Irvine, Dept Med, Div Infect Dis, Irvine, CA 92717 USA. RP Szoka, FC (reprint author), Univ Calif San Francisco, Sch Pharm, Dept Bioengn, San Francisco, CA 94143 USA. EM szoka@cgl.ucsf.edu FU NIH [R01 GM061851, R21 AI093135, HHSN27201100016C]; U.S. Army Medical Research and Material Command [DAMD17-93-V-3004]; Henry M. Jackson Foundation; Division of AIDS, NIAID, NIH; NIAID, NIH [F32AI095062] FX This work was supported by NIH grants R01 GM061851, R21 AI093135, and HHSN27201100016C and by cooperative agreement DAMD17-93-V-3004 between the U.S. Army Medical Research and Material Command, the Henry M. Jackson Foundation, and the Division of AIDS, NIAID, NIH. V. J. Venditto was supported by Ruth L. Kirschstein National Research Service Award F32AI095062 from the NIAID, NIH. NR 44 TC 5 Z9 5 U1 2 U2 10 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 EI 1556-679X J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD AUG PY 2014 VL 21 IS 8 BP 1086 EP 1093 DI 10.1128/CVI.00320-14 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AO8SH UT WOS:000341624000008 PM 24872518 ER PT J AU Mudhasani, R Kota, KP Retterer, C Tran, JP Whitehouse, CA Bavari, S AF Mudhasani, Rajini Kota, Krishna P. Retterer, Cary Tran, Julie P. Whitehouse, Chris A. Bavari, Sina TI High Content Image-Based Screening of a Protease Inhibitor Library Reveals Compounds Broadly Active against Rift Valley Fever Virus and Other Highly Pathogenic RNA Viruses SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID CYTOPLASMIC TAILS; DENGUE VIRUS; GLYCOPROTEINS; PCR; MICROTUBULES; EXPRESSION; INFECTION; EPIDEMIC; DISEASE; MITOSIS AB High content image-based screening was developed as an approach to test a protease inhibitor small molecule library for antiviral activity against Rift Valley fever virus (RVFV) and to determine their mechanism of action. RVFV is the causative agent of severe disease of humans and animals throughout Africa and the Arabian Peninsula. Of the 849 compounds screened, 34 compounds exhibited >= 50% inhibition against RVFV. All of the hit compounds could be classified into 4 distinct groups based on their unique chemical backbone. Some of the compounds also showed broad antiviral activity against several highly pathogenic RNA viruses including Ebola, Marburg, Venezuela equine encephalitis, and Lassa viruses. Four hit compounds (C795-0925, D011-2120, F694-1532 and G202-0362), which were most active against RVFV and showed broad-spectrum antiviral activity, were selected for further evaluation for their cytotoxicity, dose response profile, and mode of action using classical virological methods and high-content imaging analysis. Time-of-addition assays in RVFV infections suggested that D011-2120 and G202-0362 targeted virus egress, while C795-0925 and F694-1532 inhibited virus replication. We showed that D011-2120 exhibited its antiviral effects by blocking microtubule polymerization, thereby disrupting the Golgi complex and inhibiting viral trafficking to the plasma membrane during virus egress. While G202-0362 also affected virus egress, it appears to do so by a different mechanism, namely by blocking virus budding from the trans Golgi. F694-1532 inhibited viral replication, but also appeared to inhibit overall cellular gene expression. However, G202-0362 and C795-0925 did not alter any of the morphological features that we examined and thus may prove to be good candidates for antiviral drug development. Overall this work demonstrates that high-content image analysis can be used to screen chemical libraries for new antivirals and to determine their mechanism of action and any possible deleterious effects on host cellular biology. C1 [Mudhasani, Rajini; Kota, Krishna P.; Retterer, Cary; Tran, Julie P.; Whitehouse, Chris A.; Bavari, Sina] US Army Med Res Inst Infect Dis, Mol & Translat Sci Div, Frederick, MD 21702 USA. RP Mudhasani, R (reprint author), US Army Med Res Inst Infect Dis, Mol & Translat Sci Div, Frederick, MD 21702 USA. EM sina.bavari.civ@mail.mil FU Defense Threat Reduction Agency (DTRA), Joint Science and Technology Office for Chem Bio Defense [JSTO-CBM.THRV.01.10.RD.19] FX This study was supported by funding from the Defense Threat Reduction Agency (DTRA), Joint Science and Technology Office for Chem Bio Defense (JSTO-CBM.THRV.01.10.RD.19) to SB. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 37 TC 11 Z9 12 U1 1 U2 17 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD AUG PY 2014 VL 8 IS 8 AR e3095 DI 10.1371/journal.pntd.0003095 PG 16 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AO8AN UT WOS:000341574700056 PM 25144302 ER PT J AU Myint, KSA Kipar, A Jarman, RG Gibbons, RV Perng, GC Flanagan, B Mongkolsirichaikul, D Van Gessel, Y Solomon, T AF Myint, Khin Saw Aye Kipar, Anja Jarman, Richard G. Gibbons, Robert V. Perng, Guey Chuen Flanagan, Brian Mongkolsirichaikul, Duangrat Van Gessel, Yvonne Solomon, Tom TI Neuropathogenesis of Japanese Encephalitis in a Primate Model SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID CENTRAL-NERVOUS-SYSTEM; VIRUS INFECTION; NEURONAL DEATH; MICROGLIAL ACTIVATION; NITRIC-OXIDE; IN-VITRO; T-CELLS; APOPTOSIS; ANTIGEN; MACROPHAGES AB Background: Japanese encephalitis (JE) is a major cause of mortality and morbidity for which there is no treatment. In addition to direct viral cytopathology, the inflammatory response is postulated to contribute to the pathogenesis. Our goal was to determine the contribution of bystander effects and inflammatory mediators to neuronal cell death. Methodology/Principal Findings: Material from a macaque model was used to characterize the inflammatory response and cytopathic effects of JE virus (JEV). Intranasal JEV infection induced a non-suppurative encephalitis, dominated by perivascular, infiltrates of mostly T cells, alongside endothelial cell activation, vascular damage and blood brain barrier (BBB) leakage; in the adjacent parenchyma there was macrophage infiltration, astrocyte and microglia activation. JEV antigen was mostly in neurons, but there was no correlation between intensity of viral infection and degree of inflammatory response. Apoptotic cell death occurred in both infected and non-infected neurons. Interferon-a, which is a microglial activator, was also expressed by both. Tumour Necrosis Factor-a, inducible nitric oxide synthase and nitrotyrosine were expressed by microglial cells, astrocytes and macrophages. The same cells expressed matrix metalloproteinase (MMP)-2 whilst MMP-9 was expressed by neurons. Conclusions/Significance: The results are consistent with JEV inducing neuronal apoptotic death and release of cytokines that initiate microglial activation and release of pro-inflammatory and apoptotic mediators with subsequent apoptotic death of both infected and uninfected neurons. Activation of astrocytes, microglial and endothelial cells likely contributes to inflammatory cell recruitment and BBB breakdown. It appears that neuronal apoptotic death and activation of microglial cells and astrocytes play a crucial role in the pathogenesis of JE. C1 [Myint, Khin Saw Aye; Jarman, Richard G.; Gibbons, Robert V.; Mongkolsirichaikul, Duangrat; Van Gessel, Yvonne] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Myint, Khin Saw Aye; Solomon, Tom] Univ Liverpool, Inst Infect & Global Hlth, NIHR Hlth Protect Res Unit Emerging & Zoonot Infe, Brain Infect Grp, Liverpool L69 3BX, Merseyside, England. [Myint, Khin Saw Aye; Solomon, Tom] Univ Liverpool, Walton Ctr NHS Fdn Trust, Liverpool L69 3BX, Merseyside, England. [Kipar, Anja] Univ Liverpool, Sch Vet Sci, Liverpool L69 3BX, Merseyside, England. [Kipar, Anja] Univ Liverpool, Dept Infect Biol, Inst Global Hlth, Liverpool L69 3BX, Merseyside, England. [Perng, Guey Chuen] Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA USA. [Perng, Guey Chuen] Natl Cheng Kung Univ, Coll Med, Dept Microbiol & Immunol, Tainan 70101, Taiwan. [Perng, Guey Chuen] Natl Cheng Kung Univ, Ctr Infect Dis & Signal Res, Tainan 70101, Taiwan. [Flanagan, Brian] Univ Liverpool, Dept Clin Infect Microbiol & Immunol, Inst Infect & Global Hlth, Liverpool L69 3BX, Merseyside, England. RP Myint, KSA (reprint author), Eijkman Inst, Emerging Virus Res Lab, Jakarta, Indonesia. EM tsolomon@liverpool.ac.uk RI Kipar, Anja/L-7214-2014; OI Perng, Oscar/0000-0001-7510-4486; Solomon, Tom/0000-0001-7266-6547 FU U.S. Army Medical Research and Materiel Command FX This work was supported by the U.S. Army Medical Research and Materiel Command. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 42 TC 10 Z9 11 U1 1 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD AUG PY 2014 VL 8 IS 8 AR e2980 DI 10.1371/journal.pntd.0002980 PG 11 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AO8AN UT WOS:000341574700003 PM 25102067 ER PT J AU Whitehorn, J Yacoub, S Anders, KL Macareo, LR Cassetti, MC Van, VCN Shi, PY Wills, B Simmons, CP AF Whitehorn, James Yacoub, Sophie Anders, Katherine L. Macareo, Louis R. Cassetti, M. Cristina Vinh Chau Nguyen Van Shi, Pei-Yong Wills, Bridget Simmons, Cameron P. TI Dengue Therapeutics, Chemoprophylaxis, and Allied Tools: State of the Art and Future Directions SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Review ID PLACEBO-CONTROLLED TRIAL; RANDOMIZED CONTROLLED-TRIAL; VIRUS-INFECTION; SHOCK SYNDROME; SEVERE THROMBOCYTOPENIA; PLATELET TRANSFUSION; DOUBLE-BLIND; ENDOTHELIAL FUNCTION; PROTECTIVE EFFICACY; FALCIPARUM-MALARIA AB Dengue is the most common arboviral disease of humans. There is an unmet need for a therapeutic intervention that reduces the duration and severity of dengue symptoms and diminishes the likelihood of severe complications. To this end, there are active discovery efforts in industry and academia to develop interventions, with a focus on small molecule inhibitors of dengue virus replication that are suitable for therapy or chemoprophylaxis. Advancements in animal models of dengue virus infection together with the possibility of a dengue human infection model have further enhanced the platform for dengue drug discovery. Whilst drug discovery efforts gestate, there are ongoing clinical research designed to benefit today's patients, including trials of supportive care interventions, and descriptive studies that should improve the ability of clinicians to make an accurate diagnosis early in the illness course and to identify patients most at risk of progression to severe disease. This review provides a state of the art summary of dengue drug discovery, clinical trials, and supportive allied research and reflects discussions at the 2nd International Dengue Therapeutics Workshop held in Ho Chi Minh City, Vietnam, in December 2013. C1 [Whitehorn, James] London Sch Hyg & Trop Med, Dept Clin Res, London WC1, England. [Whitehorn, James; Yacoub, Sophie; Anders, Katherine L.; Wills, Bridget; Simmons, Cameron P.] Univ Oxford, Clin Res Unit, Hosp Trop Dis, Ho Chi Minh City, Vietnam. [Yacoub, Sophie] Univ London Imperial Coll Sci Technol & Med, Dept Med, London, England. [Macareo, Louis R.] US Army Med Component, Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Cassetti, M. Cristina] NIAID, Bethesda, MD 20892 USA. [Vinh Chau Nguyen Van] Hosp Trop Dis, Ho Chi Minh City, Vietnam. [Shi, Pei-Yong] Novartis Inst Trop Dis, Singapore, Singapore. [Wills, Bridget; Simmons, Cameron P.] Univ Oxford, Ctr Trop Med, Oxford, England. [Simmons, Cameron P.] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3052, Australia. RP Whitehorn, J (reprint author), London Sch Hyg & Trop Med, Dept Clin Res, London WC1, England. EM csimmons@oucru.org OI Simmons, Cameron P./0000-0002-9039-7392 FU Wellcome Trust of the United Kingdom [097430/Z/11/Z, 100562/Z/12/Z]; National Health and Medical Research Council, Australia (NHMRC) [1047282]; National Medical Research Council in Singapore FX JW and SY are supported by fellowships from the Wellcome Trust of the United Kingdom (grants 097430/Z/11/Z and 100562/Z/12/Z respectively). CPS is supported by the National Health and Medical Research Council, Australia (NHMRC ID: 1047282). PYS was partially supported by the TCR flagship "STOP Dengue'' program from National Medical Research Council in Singapore. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 71 TC 17 Z9 18 U1 0 U2 11 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD AUG PY 2014 VL 8 IS 8 AR e3025 DI 10.1371/journal.pntd.0003025 PG 6 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AO8AN UT WOS:000341574700018 PM 25166493 ER PT J AU Carbone, JW Pasiakos, SM Vislocky, LM Anderson, JM Rodriguez, NR AF Carbone, John W. Pasiakos, Stefan M. Vislocky, Lisa M. Anderson, Jeffrey M. Rodriguez, Nancy R. TI Effects of short-term energy deficit on muscle protein breakdown and intramuscular proteolysis in normal-weight young adults SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM-PHYSIOLOGIE APPLIQUEE NUTRITION ET METABOLISME LA English DT Article DE proteolysis; ubiquitin; weight loss; caspase-3; aerobic exercise; energy deficit; fractional breakdown rate ID GASTRIC-CANCER PATIENTS; INCREASED LEUCINE FLUX; HUMAN SKELETAL-MUSCLE; FAT-FREE MASS; ENDURANCE EXERCISE; DIETARY-PROTEIN; POSTMENOPAUSAL WOMEN; RESISTANCE EXERCISE; PROTEASOME ACTIVITY; BODY-COMPOSITION AB The effects of short-term energy deficit (ED) on direct measures of muscle proteolysis and the intracellular mechanisms by which muscle proteins are degraded at rest and following aerobic exercise are not well described. This study evaluated the effects of a short-term diet-induced ED, on muscle fractional breakdown rate (FBR), intramuscular 26S proteasome activity, caspase-3 activation, and PSMA2 and MAFbx expression at rest, in the postabsorptive state, and following a single bout of moderate aerobic exercise (45 min at 65% peak oxygen uptake). Six men and 4 women participated in two 10-day diet interventions: weight maintenance (WM) followed by ED (80% estimated energy requirements). Dietary protein (1.5 g.kg(-1).day(-1)) intake was constant for WM and ED. Mixed muscle FBR, proteasome activity, and intracellular proteolytic factor expression were measured using stable isotope methodology, fluorescent enzyme activity assays, and Western blotting, respectively. Overall, FBR and caspase-3 activation increased 60% and 11%, respectively, in response to ED (P < 0.05), but were not influenced by exercise. During ED, 26S proteasome alpha-subunit PSMA2 expression was 25% higher (P < 0.05) after exercise compared with rest. Exercise did not influence PSMA2 expression during WM, and MAFbx expression and 26S proteasome activity were not affected by ED or exercise. These data illustrate the effects of short-term, moderate ED on muscle protein degradation. In the context of skeletal muscle integrity during weight loss interventions, this work demonstrates a need for further investigations aimed at mitigating muscle loss associated with energy deficit imposed for intentional reduction of total body weight. C1 [Carbone, John W.] Eastern Michigan Univ, Sch Hlth Sci, Ypsilanti, MI 48197 USA. [Pasiakos, Stefan M.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. [Vislocky, Lisa M.; Rodriguez, Nancy R.] Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA. [Anderson, Jeffrey M.] Univ Connecticut, Dept Kinesiol, Storrs, CT 06269 USA. RP Carbone, JW (reprint author), Eastern Michigan Univ, Sch Hlth Sci, 312 Marshall Bldg, Ypsilanti, MI 48197 USA. EM jcarbon2@emich.edu RI Pasiakos, Stefan/E-6295-2014 OI Pasiakos, Stefan/0000-0002-5378-5820 NR 59 TC 3 Z9 3 U1 0 U2 7 PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS PI OTTAWA PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA SN 1715-5312 EI 1715-5320 J9 APPL PHYSIOL NUTR ME JI Appl. Physiol. Nutr. Metab. PD AUG PY 2014 VL 39 IS 8 BP 960 EP 968 DI 10.1139/apnm-2013-0433 PG 9 WC Nutrition & Dietetics; Physiology; Sport Sciences SC Nutrition & Dietetics; Physiology; Sport Sciences GA AO7VC UT WOS:000341559700013 PM 24945715 ER PT J AU Wang, D Abdelzaher, T Kaplan, L AF Wang, Dong Abdelzaher, Tarek Kaplan, Lance TI Surrogate Mobile Sensing SO IEEE COMMUNICATIONS MAGAZINE LA English DT Article AB The proliferation of smart phones with sensing capabilities motivates exploring the applicability limits of (phone-based) mobile sensing. While a phone can directly measure variables such as location, acceleration, and orientation, other interesting quantities one may want to measure have higher-level semantics that a phone does not directly recognize. For example, one might want to map parking lots that are free after hours, or restaurants that are popular after midnight. How can we measure such higher-level logical quantities using sensors on phones? Techniques that address this question fall in the broad area of surrogate sensing, defined as inferring high-level logical quantities by measuring weaker surrogates. The surrogates in question are variables that can be sensed using a phone, but are only weakly related to the original high-level logical quantities one is really after. The key challenge is to exploit appropriate aggregation techniques that leverage the availability of large numbers of phones to overcome the poor quality of individual surrogates. Recently, significant advances have been made in understanding the quality limits of surrogate sensing. This article overviews the main ideas and insights underlying these advances. C1 [Wang, Dong] Univ Notre Dame, Notre Dame, IN 46556 USA. [Abdelzaher, Tarek] Univ Illinois, Urbana, IL USA. [Kaplan, Lance] US Army, Res Lab, Kansas City, KS USA. RP Wang, D (reprint author), Univ Notre Dame, Dept Comp Sci & Engn, Notre Dame, IN 46556 USA. EM zaher@cs.uiuc.edu FU Army Research Laboratory [W911NF-09-2-0053]; DTRA [HDTRA1-10-1-0120]; NSF [CNS 10-59294, CNS 10-35736] FX Research reported in this article was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement W911NF-09-2-0053, DTRA grant HDTRA1-10-1-0120, and NSF grants CNS 10-59294 and CNS 10-35736. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation here on. NR 12 TC 8 Z9 8 U1 0 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0163-6804 EI 1558-1896 J9 IEEE COMMUN MAG JI IEEE Commun. Mag. PD AUG PY 2014 VL 52 IS 8 BP 36 EP 41 PG 6 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA AO7IX UT WOS:000341527800005 ER PT J AU Lawson, K Bayne, SB Lacouture, S Cheng, L O'Brien, H Ogunniyi, A Scozzie, C AF Lawson, Kevin Bayne, Stephen B. Lacouture, Shelby Cheng, Lin O'Brien, Heather Ogunniyi, Aderinto Scozzie, Charles TI Safe Operating Area and Long-Term Reliability of 9-kV Silicon Carbide PNPN Super Gate Turn-Off Thyristors SO IEEE ELECTRON DEVICE LETTERS LA English DT Article DE Electronic devices; life testing; semiconductor devices; semiconductor device reliability; semiconductor device testing; SGTO; silicon carbide; safe operating area; power semiconductor switches; thyristors; wide band gap semiconductors ID DEVICES AB One of the major requirements for adoption of new silicon carbide (SiC) super gate turn-off thyristors (SGTOs) into high-energy applications is to verify the safe operating area and long-term reliability capabilities of these devices. In this letter, we have developed a unique high-energy testing system that can evaluate the performance limitations with respect to lifetime capabilities of the 9 kV, 1 cm(2), SGTOs at ultrahigh pulsed current levels from 1 to 3.5 kA. The test system produces square current pulses with a user specified current amplitude and a 100-mu s pulsewidth at a maximum repetition rate of 1 shot/s (>0.1% duty cycle). A lifetime safe operating area with respect to maximum pulsed current was then established that these 1 cm(2), 9 kV, SiC SGTOs can perform reliably without significant degradation at pulsed current levels up to 2.0 kA. At current levels above 2.0 kA shifts in the on-state voltage are observed probably due to device over-heating at such high current levels and having not enough time to fully dissipate the heat between any two shots, which results in the device rapidly deteriorating due to increased on-state losses ultimately leading to premature failure. C1 [Lawson, Kevin; Bayne, Stephen B.; Lacouture, Shelby] Texas Tech Univ, Ctr Pulsed Power & Power Elect, Lubbock, TX 79409 USA. [Cheng, Lin] Cree Inc, Durham, NC 27703 USA. [O'Brien, Heather; Ogunniyi, Aderinto; Scozzie, Charles] US Army, Res Lab, Adelphi, MD 20783 USA. RP Lawson, K (reprint author), Texas Tech Univ, Ctr Pulsed Power & Power Elect, Lubbock, TX 79409 USA. EM kevin.lawson@ttu.edu FU U.S. Army Research Laboratory, Adelphi, MD, USA FX This work was supported by the U.S. Army Research Laboratory, Adelphi, MD, USA. The review of this letter was arranged by Editor W. T. Ng. NR 11 TC 6 Z9 6 U1 0 U2 14 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0741-3106 EI 1558-0563 J9 IEEE ELECTR DEVICE L JI IEEE Electron Device Lett. PD AUG PY 2014 VL 35 IS 8 BP 862 EP 864 DI 10.1109/LED.2014.2329795 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA AO7ZY UT WOS:000341573000018 ER PT J AU Pulskamp, JS Bedair, SS Polcawich, RG Meyer, CD Kierzewski, I Maack, B AF Pulskamp, Jeffrey S. Bedair, Sarah S. Polcawich, Ronald G. Meyer, Christopher D. Kierzewski, Iain Maack, Bryan TI High-Q and Capacitance Ratio Multilayer Metal-on-Piezoelectric RF MEMS Varactors SO IEEE ELECTRON DEVICE LETTERS LA English DT Article DE Microelectromechanical devices; microwave devices; capacitors; tunable devices; piezoelectric devices ID ACTUATION AB This letter documents the design and characterization of integrated and continuously tuned, radio frequency multilayer metal noncontact varactors with low-power, large-displacement, thin-film lead zirconate titanate (PZT) actuators. The devices, with capacitances in the 0.019-0.23-pF range, achieved high quality factors at the maximum capacitance state (Q = 100 at 8.7 GHz) and tuning ratios as high as 11.6: 1 at 20 V actuation with nW-power consumption. The devices utilize three electroplated copper (Cu) layers (similar to 10 mu m per layer) directly fabricated on PZT microelectromechanical system actuators. C1 [Pulskamp, Jeffrey S.; Bedair, Sarah S.; Polcawich, Ronald G.; Meyer, Christopher D.; Kierzewski, Iain; Maack, Bryan] US Army, Res Lab, Adelphi, MD 20783 USA. RP Pulskamp, JS (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA. EM jeffrey.s.pulskamp.civ@mail.mil NR 16 TC 4 Z9 4 U1 0 U2 12 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0741-3106 EI 1558-0563 J9 IEEE ELECTR DEVICE L JI IEEE Electron Device Lett. PD AUG PY 2014 VL 35 IS 8 BP 871 EP 873 DI 10.1109/LED.2014.2327611 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA AO7ZY UT WOS:000341573000021 ER PT J AU Brungart, DS Sheffield, BM Kubli, LR AF Brungart, Douglas S. Sheffield, Benjamin M. Kubli, Lina R. TI Development of a test battery for evaluating speech perception in complex listening environments SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID HEARING-IMPAIRED SUBJECTS; IN-NOISE TEST; ARTICULATION INDEX; CONSONANT RECOGNITION; INTELLIGIBILITY; TALKERS; MASKING; BENEFIT AB In the real world, spoken communication occurs in complex environments that involve audiovisual speech cues, spatially separated sound sources, reverberant listening spaces, and other complicating factors that influence speech understanding. However, most clinical tools for assessing speech perception are based on simplified listening environments that do not reflect the complexities of real-world listening. In this study, speech materials from the QuickSIN speech-in-noise test by Killion, Niquette, Gudmundsen, Revit, and Banerjee [J. Acoust. Soc. Am. 116, 2395-2405 (2004)] were modified to simulate eight listening conditions spanning the range of auditory environments listeners encounter in everyday life. The standard QuickSIN test method was used to estimate 50% speech reception thresholds (SRT50) in each condition. A method of adjustment procedure was also used to obtain subjective estimates of the lowest signal-to-noise ratio (SNR) where the listeners were able to understand 100% of the speech (SRT100) and the highest SNR where they could detect the speech but could not understand any of the words (SRT0). The results show that the modified materials maintained most of the efficiency of the QuickSIN test procedure while capturing performance differences across listening conditions comparable to those reported in previous studies that have examined the effects of audiovisual cues, binaural cues, room reverberation, and time compression on the intelligibility of speech. C1 [Brungart, Douglas S.; Sheffield, Benjamin M.; Kubli, Lina R.] Walter Reed Natl Mil Med Ctr, Bethesda, MD 20889 USA. [Sheffield, Benjamin M.; Kubli, Lina R.] US Army Publ Hlth Command, Bethesda, MD 20889 USA. RP Brungart, DS (reprint author), Walter Reed Natl Mil Med Ctr, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM douglas.s.brungart.civ@health.mil FU Army Hearing Program; Defense Medical Research and Development Program [D61_I_10_J8_261] FX Portions of this work were funded by the Army Hearing Program and a grant from Defense Medical Research and Development Program (Proposal Number D61_I_10_J8_261). The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Army, the Department of the Navy, the Department of the Air Force, the Department of Defense, nor the U.S. Government. NR 22 TC 2 Z9 2 U1 1 U2 14 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 EI 1520-8524 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD AUG PY 2014 VL 136 IS 2 BP 777 EP 790 DI 10.1121/1.4887440 PG 14 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA AO2TE UT WOS:000341178100055 PM 25096112 ER PT J AU Carlson, LA Ferguson, DP Kenefick, RW AF Carlson, Lara A. Ferguson, David P. Kenefick, Robert W. TI Physiological strain of stock car drivers during competitive racing SO JOURNAL OF THERMAL BIOLOGY LA English DT Article DE Thermoregulation; Motorsports athletes; NASCAR; Speedway ID HEAT-STRESS; UNCOMPENSABLE HEAT; BLOOD-PRESSURE; STROKE VOLUME; PERFORMANCE; RESPONSES; BODY; ACCELERATION; HYPERTHERMIA; TEMPERATURE AB Heat strain experienced by motorsport athletes competing in National Association for Stock Car Automobile Racing (NASCAR) may be significant enough to impair performance or even result in a life-threatening accident. There is a need to carefully quantify heat strain during actual NASCAR race competitions in order to faithfully represent the magnitude of the problem and conceptualize future mitigation practices. The purpose of this investigation was to quantify the thermoregulatory and physiological strain associated with competitive stock car driving. Eight male stock car drivers (29.0 +/- 10.0 yr; 176.2 +/- 3.3 cm, 80.6 +/- 15.7 kg) participated in sanctioned stock car races. Physiological measurements included intestinal core (T-c) and skin (T-sk) temperatures, heart rate (HR), blood pressure, and body mass before and after completion of the race. Pre-race T-c was 38.1 +/- 0.1 degrees C which increased to 38.6 +/- 0.2 degrees C post-race (p=0.001). T-sk increased from 36.1 +/- 0.2 degrees C pre-race to 37.3 +/- 0.3 degrees C post-race (p=0.001) whereas the core-to-skin temperature gradient decreased from a pre-race value of 2.0 +/- 0.3 degrees C to 1.3 +/- 0.3 degrees C post-race (p=0.005). HRs post-race were 80 +/- 0.1% of the drivers' age-predicted maximum HR. Physiological Strain Index (PSI) post-race was 4.9, which indicates moderate strain. Drivers' thermal sensation based on the ASHRAE Scale increased from 1.3 +/- 0.5 to 2.8 +/- 0.4, and their perception of exertion (RPE) responses also increased from 8.4 +/- 1.6 to 13.9 +/- 1.8 after competition. Heat strain associated with competitive stock car racing is significant. These findings suggest the need for heat mitigation practices and provide evidence that motorsport should consider strategies to become heat acclimatized to better meet the thermoregulatory and cardiovascular challenges of motorsport competition. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Carlson, Lara A.] Univ New England, Biddeford, ME 04005 USA. [Ferguson, David P.] Baylor Coll Med, Childrens Nutr Res Ctr, Houston, TX 77030 USA. [Kenefick, Robert W.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. RP Carlson, LA (reprint author), Univ New England, 11 Hills Beach Rd, Biddeford, ME 04005 USA. EM lcarlson@une.edu; David.Ferguson@bcm.edu; Robert.Kenefick@us.army.mil NR 35 TC 1 Z9 1 U1 1 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0306-4565 J9 J THERM BIOL JI J. Therm. Biol. PD AUG PY 2014 VL 44 BP 20 EP 26 DI 10.1016/j.jtherbio.2014.06.001 PG 7 WC Biology; Zoology SC Life Sciences & Biomedicine - Other Topics; Zoology GA AO6QZ UT WOS:000341477900004 PM 25086969 ER PT J AU Najmaei, S Amani, M Chin, ML Liu, Z Birdwell, AG O'Regan, TP Ajayan, PM Dubey, M Lou, J AF Najmaei, Sina Amani, Matin Chin, Matthew L. Liu, Zheng Birdwell, A. Glen O'Regan, Terrance P. Ajayan, Pulickel M. Dubey, Madan Lou, Jun TI Electrical Transport Properties of Polycrystalline Monolayer Molybdenum Disulfide SO ACS NANO LA English DT Article DE two-dimensional materials; MoS2; polycrystallinity; grain boundaries; electronic transport ID CHEMICAL-VAPOR-DEPOSITION; FIELD-EFFECT TRANSISTORS; MOS2 ATOMIC LAYERS; GRAIN-BOUNDARIES; LARGE-AREA; VALLEY POLARIZATION; PHASE GROWTH; GRAPHENE; FILMS AB Semiconducting MoS2 monolayers have shown many promising electrical properties, and the inevitable polycrystallinity in synthetic, large-area films renders understanding the effect of structural defects, such as grain boundaries (GBs, or line-defects in two-dimensional materials), essential. In this work, we first examine the role of GBs in the electrical transport properties of MoS2 monolayers with varying line-defect densities. We reveal a systematic degradation of electrical characteristics as the line-defect density increases. The two common MoS2 GB types and their specific roles are further examined, and we find that only tilt GBs have a considerable effect on the MoS2 electrical properties. By examining the electronic states and sources of disorder using temperature-dependent transport studies, we adopt the Anderson model for disordered systems to explain the observed transport behaviors in different temperature regimes. Our results elucidate the roles played by GBs in different scenarios and give insights into their underlying scattering mechanisms. C1 [Najmaei, Sina; Liu, Zheng; Ajayan, Pulickel M.; Lou, Jun] Rice Univ, Dept Mat Sci & NanoEngn, Houston, TX 77005 USA. [Amani, Matin; Chin, Matthew L.; Birdwell, A. Glen; O'Regan, Terrance P.; Dubey, Madan] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20723 USA. RP Dubey, M (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20723 USA. EM jlou@rice.edu RI Liu, Zheng/C-1813-2014 OI Liu, Zheng/0000-0002-8825-7198 FU Welch Foundation [C-1716]; NSF [DMR-1327093]; U.S. Army Research Office (MURI) [W911NF-11-1-0362]; U.S. Office of Naval Research (MURI) [N000014-09-1-1066]; Nanoelectronics Research Corporation [S201006]; National Science Foundation [DMR-0938330]; Singapore National Research Foundation under NRF RF [NRF-RF2013-08]; Nanyang Technological University [M4081137.070] FX This work was supported by the Welch Foundation (Grant No. C-1716), the NSF (Grant No. DMR-1327093), the U.S. Army Research Office (MURI Grant No. W911NF-11-1-0362), the U.S. Office of Naval Research (MURI Grant No. N000014-09-1-1066), and the Nanoelectronics Research Corporation contract S201006. This research was also supported in part by the National Science Foundation through Grant No. DMR-0938330. M.D., M.A., M.L.C., A.G.B., and T.P.O. acknowledge the support of the ARL Director's Strategic Initiative (DSI) program on interfaces in stacked 2D atomic layered materials. The authors would also like to thank Dr. Pani Varanasi, ARO for his in-depth technical discussion on 2D atomic layer R&D. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the ARL or the U.S. Government This work was also supported by the Singapore National Research Foundation under NRF RF Award No. NRF-RF2013-08, the start-up funding from Nanyang Technological University (M4081137.070). NR 28 TC 28 Z9 28 U1 9 U2 121 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1936-0851 EI 1936-086X J9 ACS NANO JI ACS Nano PD AUG PY 2014 VL 8 IS 8 BP 7930 EP 7937 DI 10.1021/nn501701a PG 8 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA AO0IM UT WOS:000340992300038 PM 25019978 ER PT J AU Kellicut, DC Kuncir, EJ Williamson, HM Masella, PC Nielsen, PE AF Kellicut, Dwight C. Kuncir, Eric J. Williamson, Hope M. Masella, Pamela C. Nielsen, Peter E. TI Surgical Team Assessment Training: improving surgical teams during deployment SO AMERICAN JOURNAL OF SURGERY LA English DT Article DE Simulation; Trauma training; TeamSTEPPS ID OPERATING-ROOM; COMMUNICATION; CARE; COLLABORATION; DELIVERY; AVIATION; OUTCOMES; SAFETY; TRIAL AB BACKGROUND: Simulation and team training are accepted as critical patient safety strategies to improve team performance and can help achieve better outcomes. Standardized and realistic drills conducted by skilled physicians and nurses who demonstrate consistent use of principles which enhance communication and teamwork increase the likelihood of improved clinical outcomes. METHODS: Two, 4-member surgeon/nurse teams traveled to 8 Army surgical resuscitation medical treatment facilities in Iraq during July and August 2011. At each site, a new program called Surgical Team Assessment Training was introduced and implemented to 220 military personnel. Two multi-patient scenarios were designed to test resuscitative and operating room medical decision-making, communication, and co-ordination of care. In addition, 2 hours of didactic instruction emphasized principles of TeamSTEPPS applied to emergency and operating rooms during care of patients with multiple, complex traumatic injuries. Anonymous surveys were completed by participants following the training. RESULTS: Participants were significantly more likely to rate this training as very helpful following training compared with their opinion before participation (53% vs 37%, P < .05). Seventy-seven percent felt that it would improve overall patient outcomes, 78% said it would likely contribute to saving lives in combat, and 98% felt it should be provided to military Emergency Medicine and Surgical residents. CONCLUSIONS: Surgical Team Assessment Training can be successfully implemented in an austere, hostile environment and improve trauma team function by incorporating simulation training models and TeamSTEPPs concepts. Expansion of this program for predeployment and resident training is currently under investigation based on the extremely positive responses. Published by Elsevier Inc. C1 [Kellicut, Dwight C.; Masella, Pamela C.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Kuncir, Eric J.] Naval Med Ctr San Diego, San Diego, CA USA. [Williamson, Hope M.] 86th Combat Support Hosp, Ft Campbell, KY USA. [Nielsen, Peter E.] Madigan Army Med Ctr, Tacoma, WA 98431 USA. RP Kellicut, DC (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM dwight.c.kellicut.mil@mail.mil OI Kuncir, Eric/0000-0001-6548-8308 NR 19 TC 3 Z9 3 U1 1 U2 10 PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC PI BRIDGEWATER PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA SN 0002-9610 EI 1879-1883 J9 AM J SURG JI Am. J. Surg. PD AUG PY 2014 VL 208 IS 2 BP 275 EP 283 DI 10.1016/j.amjsurg.2014.03.008 PG 9 WC Surgery SC Surgery GA AO2KC UT WOS:000341149400019 PM 24946726 ER PT J AU Ma, L He, T Leung, KK Swami, A Towsley, D AF Ma, Liang He, Ting Leung, Kin K. Swami, Ananthram Towsley, Don TI Inferring Link Metrics From End-To-End Path Measurements: Identifiability and Monitor Placement SO IEEE-ACM TRANSACTIONS ON NETWORKING LA English DT Article DE Identifiability condition; linear algebraic model; monitor placement; network tomography ID NETWORK TOMOGRAPHY; DELAY; INFERENCE AB We investigate the problem of identifying individual link metrics in a communication network from end-to-end path measurements, under the assumption that linkmetrics are additive and constant. To uniquely identify the link metrics, the number of linearly independent measurement paths must equal the number of links. Our contribution is to characterize this condition in terms of the network topology and the number/placement of monitors, under the constraint that measurement paths must be cycle-free. Our main results are: 1) it is generally impossible to identify all the link metrics by using two monitors; 2) nevertheless, metrics of all the interior links not incident to any monitor are identifiable by two monitors if the topology satisfies a set of necessary and sufficient connectivity conditions; 3) these conditions naturally extend to a necessary and sufficient condition for identifying all the link metrics using three or more monitors. We show that these conditions not only facilitate efficient identifiability tests, but also enable an efficient algorithm to place the minimum number of monitors in order to identify all link metrics. Our evaluations on both random and real topologies show that the proposed algorithm achieves identifiability using a much smaller number of monitors than a baseline solution. C1 [Ma, Liang; Leung, Kin K.] Univ London Imperial Coll Sci Technol & Med, London SW7 2BT, England. [He, Ting] IBM TJ Watson Res Ctr, Yorktown Hts, NY 10598 USA. [Swami, Ananthram] Army Res Lab, Adelphi, MD 20783 USA. [Towsley, Don] Univ Massachusetts, Amherst, MA 01003 USA. RP Ma, L (reprint author), Univ London Imperial Coll Sci Technol & Med, London SW7 2BT, England. EM l.ma10@imperial.ac.uk; the@us.ibm.com; kin.leung@imperial.ac.uk; a.swami@ieee.org; towsley@cs.umass.edu FU U.S. Army Research Laboratory; U.K. Ministry of Defence [W911NF-06-3-0001] FX This work was supported in part by the U.S. Army Research Laboratory and the U.K. Ministry of Defence and was accomplished under Agreement No. W911NF-06-3-0001. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the U.S. Army Research Laboratory, the U.S. Government, the U.K. Ministry of Defence, or the U.K. Government. The U.S. and U.K. Governments are authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon. NR 39 TC 4 Z9 4 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1063-6692 EI 1558-2566 J9 IEEE ACM T NETWORK JI IEEE-ACM Trans. Netw. PD AUG PY 2014 VL 22 IS 4 BP 1351 EP 1368 DI 10.1109/TNET.2014.2328668 PG 18 WC Computer Science, Hardware & Architecture; Computer Science, Theory & Methods; Engineering, Electrical & Electronic; Telecommunications SC Computer Science; Engineering; Telecommunications GA AN9RA UT WOS:000340944200025 ER PT J AU Toblin, RL Quartana, PJ Riviere, LA Walper, KC Hoge, CW AF Toblin, Robin L. Quartana, Phillip J. Riviere, Lyndon A. Walper, Kristina Clarke Hoge, Charles W. TI Chronic Pain and Opioid Use in US Soldiers After Combat Deployment SO JAMA INTERNAL MEDICINE LA English DT Letter C1 [Toblin, Robin L.; Quartana, Phillip J.; Riviere, Lyndon A.; Walper, Kristina Clarke; Hoge, Charles W.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. [Toblin, Robin L.] US PHS, Commissioned Corps, Rockville, MD USA. RP Toblin, RL (reprint author), US PHS, Commissioned Corps, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM robin.l.toblin.mil@mail.mil NR 6 TC 18 Z9 18 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6106 EI 2168-6114 J9 JAMA INTERN MED JI JAMA Intern. Med. PD AUG PY 2014 VL 174 IS 8 BP 1400 EP 1401 DI 10.1001/jamainternmed.2014.2726 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA AN2WP UT WOS:000340447000042 PM 24978399 ER PT J AU Jonas, WB Schoomaker, EB AF Jonas, Wayne B. Schoomaker, Eric B. TI Pain and Opioids in the Military: We Must Do Better SO JAMA INTERNAL MEDICINE LA English DT Editorial Material C1 [Jonas, Wayne B.] Samueli Inst, Alexandria, VA USA. [Schoomaker, Eric B.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Jonas, WB (reprint author), US Army, Samueli Inst, 1737 King St,Ste 600, Alexandria, VA 22314 USA. EM wjonas@siib.org NR 8 TC 3 Z9 3 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6106 EI 2168-6114 J9 JAMA INTERN MED JI JAMA Intern. Med. PD AUG PY 2014 VL 174 IS 8 BP 1402 EP 1403 DI 10.1001/jamainternmed.2014.2114 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA AN2WP UT WOS:000340447000043 PM 24978149 ER PT J AU Ingalls, N Zonies, D Bailey, JA Martin, KD Iddins, BO Carlton, PK Hanseman, D Branson, R Dorlac, W Johannigman, J AF Ingalls, Nichole Zonies, David Bailey, Jeffrey A. Martin, Kathleen D. Iddins, Bart O. Carlton, Paul K. Hanseman, Dennis Branson, Richard Dorlac, Warren Johannigman, Jay TI A Review of the First 10 Years of Critical Care Aeromedical Transport During Operation Iraqi Freedom and Operation Enduring Freedom The Importance of Evacuation Timing SO JAMA SURGERY LA English DT Review ID COMBAT CASUALTY CARE AB IMPORTANCE Advances in the care of the injured patient are perhaps the only benefit of military conflict. One of the unique aspects of the military medical care system that emerged during Operation Iraqi Freedom and Operation Enduring Freedom has been the opportunity to apply existing civilian trauma system standards to the provision of combat casualty care across an evolving theater of operations. OBJECTIVES To identify differences in mortality for soldiers undergoing early and rapid evacuation from the combat theater and to evaluate the capabilities of the Critical Care Air Transport Team (CCATT) and Joint Theater Trauma Registry databases to provide adequate data to support future initiatives for improvement of performance. DESIGN, SETTING, AND PARTICIPANTS Retrospective review of CCATT records and the Joint Theater Trauma Registry from September 11, 2001, to December 31, 2010, for the in-theater military medicine health system, including centers in Iraq, Afghanistan, and Germany. Of 2899 CCATT transport records, those for 975 individuals had all the required data elements. EXPOSURE Rapid evacuation by the CCATT. MAIN OUTCOMES AND MEASURES Survival as a function of time from injury to arrival at the role IV facility at Landstuhl Regional Medical Center. RESULTS The patient cohort demonstrated a mean Injury Severity Score of 23.7 and an overall 30-day mortality of 2.1%. Mortality en route was less than 0.02%. Statistically significant differences between survivors and decedents with respect to the Injury Severity Score (mean [SD], 23.4 [12.4] vs 37.7 [16.5]; P <.001), cumulative volume of blood transfused among the patients in each group who received a transfusion (P < .001), worst base deficit (mean [SD], -3.4 [5.0] vs -7.8 [6.9]; P = .02), and worst international normalized ratio (median [interquartile range], 1.2 [1.0-1.4] vs 1.4 [1.1-2.2]; P = .03) were observed. We found no statistically significant difference between survivors and decedents with respect to time from injury to arrival at definitive care. CONCLUSIONS AND RELEVANCE Rapid movement of critically injured casualties within hours of wounding appears to be effective, with a minimal mortality incurred during movement and overall 30-day mortality. We found no association between the duration of time from wounding to arrival at Landstuhl Regional Medical Center with respect to mortality. C1 [Ingalls, Nichole] Univ Nevada, Nellis AFB, Dept Surg, Las Vegas, NV 89154 USA. [Zonies, David] Landsthul Reg Med Ctr, Crit Care Program, Kaiserslautern, Germany. [Bailey, Jeffrey A.] US Army Inst Surg Res, Joint Trauma Syst, Ft Sam Houston, TX USA. [Martin, Kathleen D.] Landstuhl Reg Med Ctr, Trauma Program, Kaiserslautern, Germany. [Iddins, Bart O.] Headquarters Air Mobil Command, Scott AFB, IL USA. [Carlton, Paul K.] US Dept HHS, Off Surg Gen, Washington, DC 20201 USA. [Hanseman, Dennis; Branson, Richard; Dorlac, Warren; Johannigman, Jay] Univ Cincinnati, Dept Surg, Div Trauma & Crit Care, Cincinnati, OH 45267 USA. RP Johannigman, J (reprint author), Univ Cincinnati, Dept Surg, Div Trauma & Crit Care, 231 Albert SabinWay,Mail Locat 0558, Cincinnati, OH 45267 USA. EM jay.johannigman@uc.edu FU Department of Surgery, University of Cincinnati FX This study was supported by internal funding from the Department of Surgery, University of Cincinnati. NR 15 TC 15 Z9 15 U1 0 U2 5 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6254 EI 2168-6262 J9 JAMA SURG JI JAMA Surg. PD AUG PY 2014 VL 149 IS 8 BP 807 EP 813 DI 10.1001/jamasurg.2014.621 PG 7 WC Surgery SC Surgery GA AN8DZ UT WOS:000340834300013 PM 25074327 ER PT J AU Scott, AM Burns, EA Hill, FC AF Scott, Andrea Michalkova Burns, Elizabeth A. Hill, Frances C. TI Theoretical study of adsorption of nitrogen-containing environmental contaminants on kaolinite surfaces SO JOURNAL OF MOLECULAR MODELING LA English DT Article DE Cluster models; M06-2X; Aqueous solution; Mineral ID MINNESOTA DENSITY FUNCTIONALS; CLAY-MINERALS; NONCOVALENT INTERACTIONS; AB-INITIO; SUBSTITUTED NITROBENZENES; NITROAROMATIC EXPLOSIVES; THERMOCHEMICAL KINETICS; MECHANISMS; 1,3,5-TRINITROBENZENE; 2,4-DINITROTOLUENE AB The adsorption of nitrogen-containing compounds (NCCs) including 2,4,6-trinitrotoluene (TNT), 2,4-dinitrotoluene (DNT), 2,4-dinitroanisole (DNAN), and 3-nitro-1,2,4-triazol-5-one (NTO) on kaolinite surfaces was investigated. The M06-2X and M06-2X-D3 density functionals were applied with the cluster approximation. Several different positions of NCCs relative to the adsorption sites of kaolinite were examined, including NCCs in perpendicular and parallel orientation toward both surface models of kaolinite. The binding between the target molecules and kaolinite surfaces was analyzed and bond energies were calculated applying the atoms in molecules (AIM) method. All NCCs were found to prefer a parallel orientation toward both kaolinite surfaces, and were bound more strongly to the octahedral than to the tetrahedral site. TNT exhibited the strongest interaction with the octahedral surface and DNAN with the tetrahedral surface of kaolinite. Hydrogen bonding was shown to be the dominant non-covalent interaction for NCCs interacting with the octahedral surface of kaolinite with a small stabilizing effect of dispersion interactions. In the case of adsorption on the tetrahedral surface, kaolonite-NCC binding was shown to be governed by the balance between hydrogen bonds and dispersion forces. The presence of water as a solvent leads to a significant decrease in the adsorption strength for all studied NCCs interacting with both kaolinite surfaces. C1 [Scott, Andrea Michalkova; Hill, Frances C.] US Army Engn Res & Dev Ctr ERDC, Vicksburg, MS 39180 USA. [Burns, Elizabeth A.] Badger Tech Serv LLC, Vicksburg, MS 39180 USA. RP Scott, AM (reprint author), US Army Engn Res & Dev Ctr ERDC, Vicksburg, MS 39180 USA. EM andrea.m.scott@usace.army.mil FU High Performance Computing Major Shared Resource Center at the Engineer Research and Development Center (ERDC, Vicksburg, MS); Environmental Quality Technology Program of the United States Army Corps of Engineers, US Army ERDC FX This work was facilitated by support from the High Performance Computing Major Shared Resource Center at the Engineer Research and Development Center (ERDC, Vicksburg, MS). The use of trade, product, or firm names in this report is for descriptive purposes only and does not imply endorsement by the US Government. Results in this study were funded and obtained from research conducted under the Environmental Quality Technology Program of the United States Army Corps of Engineers by the US Army ERDC. Permission was granted by the Chief of Engineers to publish this information. The findings of this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents. NR 48 TC 4 Z9 4 U1 3 U2 25 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1610-2940 EI 0948-5023 J9 J MOL MODEL JI J. Mol. Model. PD AUG PY 2014 VL 20 IS 8 AR 2373 DI 10.1007/s00894-014-2373-7 PG 13 WC Biochemistry & Molecular Biology; Biophysics; Chemistry, Multidisciplinary; Computer Science, Interdisciplinary Applications SC Biochemistry & Molecular Biology; Biophysics; Chemistry; Computer Science GA AN8QR UT WOS:000340869400044 PM 25031081 ER PT J AU Balent, E Edwards, M Lustik, M Martin, P AF Balent, Eric Edwards, Mary Lustik, Michael Martin, Paul TI Caudal anesthesia with sedation for inguinal hernia repair in high risk neonates SO JOURNAL OF PEDIATRIC SURGERY LA English DT Article DE Inguinal hernia; Neonate; Caudal; Regional ID FRENCH-LANGUAGE SOCIETY; POSTOPERATIVE APNEA; PREMATURE-INFANTS; PRETERM INFANTS; GENERAL-ANESTHESIA; SPINAL-ANESTHESIA; PEDIATRIC ANESTHESIOLOGISTS; REGIONAL ANESTHESIA; EPIDEMIOLOGY; CHILDREN AB Background/Purpose: The use of caudal anesthesia with sedation (CAS) has theoretical benefits over general anesthesia (GA) in high risk neonates undergoing inguinal hernia repair. This benefit has not been established in clinical studies. We compare outcomes of these two approaches at a single institution. Methods: A retrospective review was performed of all neonates and preterm infants undergoing inguinal hernia over an 8 year period. Results: Of 71 infants meeting inclusion criteria, 50 underwent repair with caudal block and systemic sedation, and 21 with general anesthesia. Minor incidents of respiratory depression requiring non invasive interventions were common in the first 24 h post operatively (24% for CAS, 14% with GA), 4% of patients receiving CAS had a respiratory complication which prolonged their hospital stay beyond 24 h post operation. Both required conversion to general anesthesia. Statistically significant differences between the two groups were lacking in terms of preoperative risk and post operative outcome. Conclusions: CAS is a safe, effective anesthetic option for high risk neonates undergoing inguinal hernia repair. Patients requiring conversion to GA from CAS may be at increased risk for complications. Large, randomized trials are needed to determine any benefit over GA. Published by Elsevier Inc. C1 [Balent, Eric; Edwards, Mary; Martin, Paul] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. [Lustik, Michael] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. RP Edwards, M (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM mary.j.edwards@us.army.mil NR 19 TC 3 Z9 3 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0022-3468 EI 1531-5037 J9 J PEDIATR SURG JI J. Pediatr. Surg. PD AUG PY 2014 VL 49 IS 8 BP 1304 EP 1307 DI 10.1016/j.jpedsurg.2013.11.005 PG 4 WC Pediatrics; Surgery SC Pediatrics; Surgery GA AN0EM UT WOS:000340256200022 PM 25092095 ER PT J AU Jensen, PR Simpson, D AF Jensen, Peter R. Simpson, Duncan TI A Qualitative Analysis of the Experience and Impact of Killing in Hand-to-Hand Combat SO JOURNAL OF TRAUMATIC STRESS LA English DT Article ID MENTAL-HEALTH SYMPTOMS; WAR VETERANS; IRAQ; AFGHANISTAN; PTSD; STRESSORS; CARE AB A growing body of research suggests that killing during military combat is closely associated with posttraumatic stress disorder (PTSD), as well as a number of other adverse mental health related conditions (e.g., dissociative experiences, violent behavior, functional impairment). This article provides first-person perspectives on the experiences and impact of killing by service members with the goal of expanding our understanding of the impact of taking a life during war. In audio-recorded phenomenological interviews, 9 service members described their experiences and the subsequent impact of killing during hand-to-hand combat. A description, supported by participant quotations, was constructed to represent the participants' experiences. Results suggest the experience and aftermath of taking a life in hand-to-hand combat was disturbing, psychologically stressful, and necessitated some form of coping after the event. Service members who killed in hand-to-hand combat viewed their actions as necessary to preserve their life and that killing in hand-to-hand combat was more emotionally taxing than killing by shooting. Our findings may help to improve providers' understanding of service members' first-person experiences of killing in hand-to-hand combat and thus provide the basis for the development of a connected and genuine relationship with such military clients. C1 [Jensen, Peter R.] Univ Tennessee, Dept Kinesiol Recreat & Sport Studies, Knoxville, TN USA. [Simpson, Duncan] Barry Univ, Sch Human Performance & Leisure Sci HPLS, Miami Shores, FL USA. RP Jensen, PR (reprint author), US Mil Acad, Ctr Enhanced Performance, Jefferson Hall,1st Floor, West Point, NY 10996 USA. EM pete.jensen1@us.army.mil NR 25 TC 1 Z9 1 U1 0 U2 13 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0894-9867 EI 1573-6598 J9 J TRAUMA STRESS JI J. Trauma Stress PD AUG PY 2014 VL 27 IS 4 BP 468 EP 473 DI 10.1002/jts.21938 PG 6 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA AO2ZQ UT WOS:000341198000012 PM 25158640 ER PT J AU Hakre, S Arteaga, GB Nunez, AE Arambu, N Aumakhan, B Liu, M Peel, SA Pascale, JM Scott, PT AF Hakre, Shilpa Arteaga, Griselda B. Nunez, Aurelio E. Arambu, Nelson Aumakhan, Bulbulgul Liu, Michelle Peel, Sheila A. Pascale, Juan M. Scott, Paul T. CA Panama HIV EPI Grp TI Prevalence of HIV, Syphilis, and Other Sexually Transmitted Infections among MSM from Three Cities in Panama SO JOURNAL OF URBAN HEALTH-BULLETIN OF THE NEW YORK ACADEMY OF MEDICINE LA English DT Article DE HIV; Syphilis; Sexually transmitted diseases; Sexual behavior; Respondent-driven sampling; Sampling hidden populations; Panama ID HIDDEN POPULATIONS; RESPONDENT; MEN; SEX; SURVEILLANCE; COUNTRIES; RISK AB Respondent-driven sampling (RDS) was used to conduct a biobehavioral survey among men who have sex with men (MSM) in three cities in the Republic of Panama. We estimated the prevalence of HIV, syphilis, and other sexually transmitted infections (STIs), sociodemographic characteristics, and sexual risk behaviors. Among 603 MSM recruited, RDS-adjusted seroprevalences (95 % confidence intervals) were: HIV-David 6.6 % (2.2-11.4 %), Panama 29.4 % (19.7-39.7 %), and Colon 32.6 % (18.0-47.8 %); active syphilis-David 16.0 % (8.9-24.2 %), Panama 24.7 % (16.7-32.9 %), Colon 31.6 % (14.8-47.5 %); resolved HBV infection-David 10.0 % (4.8-16.8 %), Panama 29.4 % (20.0-38.3 %), and Colon 40.6 % (21.9-54.4 %); herpes simplex virus type 2-David 38.4 % (27.9-48.9 %), Panama 62.6 % (52.8-71.0 %), and Colon 72.9 % (57.4-85.8 %). At least a third of MSM in each city self-identified as heterosexual or bisexual. HIV prevalence is concentrated among MSM. Preventive interventions should focus on increasing HIV and syphilis testing, and increasing promotion of condom awareness and use. C1 [Hakre, Shilpa; Liu, Michelle] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Bethesda, MD USA. [Arteaga, Griselda B.; Pascale, Juan M.] Inst Conmemorat Gorgas Estudios Salud, Panama City, Panama. [Arteaga, Griselda B.; Pascale, Juan M.] Univ Panama, Sch Med, Panama City, Panama. [Nunez, Aurelio E.] Minist Hlth, Natl HIV AIDS & STI Control Program, Panama City, Panama. [Arambu, Nelson] Del Valle Univ Guatemala, Guatemala City, Guatemala. [Aumakhan, Bulbulgul] Minist Hlth, Natl Ctr Communicable Dis, Ulaanbaatar, Mongol Peo Rep. [Peel, Sheila A.] Walter Reed Army Inst Res, US Mil HIV Res Program, HIV Diagnost & Reference Lab, Rockville, MD USA. [Scott, Paul T.] Walter Reed Army Inst Res, Dept Epidemiol & Threat Assessment, US Mil HIV Res Program, Rockville, MD USA. RP Hakre, S (reprint author), US Mil HIV Res Program, 6720-A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA. EM shakre@hivresearch.org FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense [W81XWH-07-2-0067]; National Council for Science and Technology, Panama [COL-08-059] FX The work was funded by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense, and a grant (COL-08-059) from the National Council for Science and Technology, Panama. NR 22 TC 3 Z9 3 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1099-3460 EI 1468-2869 J9 J URBAN HEALTH JI J. Urban Health PD AUG PY 2014 VL 91 IS 4 BP 793 EP 808 DI 10.1007/s11524-014-9885-4 PG 16 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA AN6AH UT WOS:000340674900015 PM 24927712 ER PT J AU Chen, D Yen, M Lin, P Groff, S Lampo, R McInerney, M Ryan, J AF Chen, Dong Yen, Max Lin, Paul Groff, Steve Lampo, Richard McInerney, Michael Ryan, Jeffrey TI A Corrosion Sensor for Monitoring the Early-Stage Environmental Corrosion of A36 Carbon Steel SO MATERIALS LA English DT Article DE carbon steel; chloride; X-ray diffraction; rust; corrosion monitoring ID CHLORIDE-INDUCED CORROSION; ALTERNATING-CURRENT; REINFORCING STEEL; MILD-STEEL; IRON; REDUCTION; CONCRETE; RUST AB An innovative prototype sensor containing A36 carbon steel as a capacitor was explored to monitor early-stage corrosion. The sensor detected the changes of the surface- rather than the bulk- property and morphology of A36 during corrosion. Thus it was more sensitive than the conventional electrical resistance corrosion sensors. After being soaked in an aerated 0.2 M NaCl solution, the sensor's normalized electrical resistance (R/R-0) decreased continuously from 1.0 to 0.74 with the extent of corrosion. Meanwhile, the sensor's normalized capacitance (C/C-0) increased continuously from 1.0 to 1.46. X-ray diffraction result indicates that the iron rust on A36 had crystals of lepidocrocite and magnetite. C1 [Chen, Dong; Yen, Max; Lin, Paul; Groff, Steve] Indiana Univ Purdue Univ, Coll Engn Technol & Comp Sci, Ft Wayne, IN 46805 USA. [Lampo, Richard; McInerney, Michael; Ryan, Jeffrey] US Army Engn Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. RP Chen, D (reprint author), Indiana Univ Purdue Univ, Coll Engn Technol & Comp Sci, 2101 E Coliseum Blvd, Ft Wayne, IN 46805 USA. EM chend@ipfw.edu; yens@ipfw.edu; lin@ipfw.edu; groff.steve@gmail.com; Richard.G.Lampo@usace.army.mil; Michael.K.McInerney@usace.army.mil; Jeffrey.P.Ryan@usace.army.mil FU US Army Engineer Research and Development Centre, Construction Engineering Research Laboratory [W9132T-10-2-0056] FX The research project was funded by the US Army Engineer Research and Development Centre, Construction Engineering Research Laboratory through the contract of W9132T-10-2-0056. The authors also thank Robert Tilbury and Mengwei Li for their help for this project. XRD was performed in the Argast Family Instrumentation and Analysis Lab at the Indiana University-Purdue University Fort Wayne. NR 36 TC 4 Z9 4 U1 1 U2 14 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1996-1944 J9 MATERIALS JI Materials PD AUG PY 2014 VL 7 IS 8 BP 5746 EP 5760 DI 10.3390/ma7085746 PG 15 WC Materials Science, Multidisciplinary SC Materials Science GA AO3EC UT WOS:000341210400023 ER PT J AU Rasmussen, TE Reilly, PA Baer, DG AF Rasmussen, Todd E. Reilly, Patricia A. Baer, David G. TI Why Military Medical Research? SO MILITARY MEDICINE LA English DT Editorial Material ID TRAUMA SYSTEM; LESSONS; EVENTS C1 [Rasmussen, Todd E.] US Combat Casualty Care Res Program, Ft Detrick, MD 21702 USA. [Reilly, Patricia A.] US Army Med Res & Mat Command, Ft Detrick, MD 21702 USA. [Baer, David G.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Rasmussen, TE (reprint author), US Combat Casualty Care Res Program, 722 Doughten St,Room 3, Ft Detrick, MD 21702 USA. NR 9 TC 6 Z9 6 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD AUG PY 2014 VL 179 IS 8 SU S SI SI BP 1 EP 2 DI 10.7205/MILMED-D-14-00245 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UP UT WOS:000340806800002 PM 25102540 ER PT J AU Hack, DC AF Hack, Dallas C. TI MEETING WARFIGHTER MEDICAL CHALLENGES Proceedings of the 2012 Military Health System Research Symposium Foreword SO MILITARY MEDICINE LA English DT Editorial Material C1 [Hack, Dallas C.] Combat Casualty Care Res Program, Ft Detrick, MD USA. [Hack, Dallas C.] US Army Med Res & Mat Command, Ft Detrick, MD USA. RP Hack, DC (reprint author), US Army Med Res & Mat Command, 504 Scott St,Bldg 810, Ft Detrick, MD 21702 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD AUG PY 2014 VL 179 IS 8 SU S SI SI BP II EP II DI 10.7205/MILMED-D-14-00243 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UP UT WOS:000340806800001 PM 25102553 ER PT J AU Reilly, PA AF Reilly, Patricia A. TI The Military Health System Research Symposium: A Short Retrospective SO MILITARY MEDICINE LA English DT Editorial Material C1 US Army Med Res & Mat Command, Ft Detrick, MD 21702 USA. RP Reilly, PA (reprint author), US Army Med Res & Mat Command, 504 Scott St,Bldg 810, Ft Detrick, MD 21702 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD AUG PY 2014 VL 179 IS 8 SU S SI SI BP 3 EP 3 DI 10.7205/MILMED-D-14-00242 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UP UT WOS:000340806800003 PM 25102541 ER PT J AU Wang, HCH Choi, JH Greene, WA Plamper, ML Cortez, HE Chavko, M Li, YS Lucca, JJD Johnson, AJ AF Wang, Heuy-Ching Hetty Choi, Jae-Hyek Greene, Whitney A. Plamper, Mark L. Cortez, Hector E. Chavko, Mikulas Li, Yansong Lucca, Jurandir J. Dalle Johnson, Anthony J. TI Pathophysiology of Blast-Induced Ocular Trauma With Apoptosis in the Retina and Optic Nerve SO MILITARY MEDICINE LA English DT Article ID OPERATION-IRAQI-FREEDOM; INJURIES AB Background: Blast-induced ocular trauma is a frequent cause of morbidity for survivors of improvised explosive devices. Blast overpressure (BOP) of 120 +/- 7 KPa has been shown to cause damage to lungs, brain, and gut in a rat model; however, the effects of BOP on ocular tissues have not been characterized. To elucidate the pathophysiology of blast-induced ocular trauma, ocular tissues from rats subjected to blast were examined for evidence of apoptosis by the detection of activated caspase 3 and TUNEL assay in their ocular tissues. Methods: A compressed air shock tube was used to deliver 120 7 KPa of BOP for duration of 2 msec to the right side of the rats.-Rats were then euthanized at specific time points after blast exposure (3 hours, 24 hours, 48 hours). Ocular tissues were processed for immunohistochemistry to detect activated caspase 3 and TUNEL assay. Tissues were evaluated for relative levels of positive signal as compared to nonblast exposed controls. Results: Activated caspase 3 was detected in the optic nerve, ganglion layer, and inner nuclear layer post blast exposure. At 24 and 48 hours, the inner nuclear layer from the right side had more cells with activated caspase 3. In the optic nerve, the highest levels of activated caspase 3 were detected on the right side at 24 hours post blast. Conclusion: BOP of 120 7 KPa induces optic neuropathy and retinal damage. In both the optic nerve and retina, caspase 3 was activated in the right and left sides following blast exposure. The results of this study reveal that blast exposure induces apoptosis in both the optic nerve and retinal tissues. C1 [Wang, Heuy-Ching Hetty; Choi, Jae-Hyek; Greene, Whitney A.; Plamper, Mark L.; Cortez, Hector E.; Johnson, Anthony J.] US Army Inst Surg Res, Ocular Trauma Task Area, Jbsa Fort Sam Houston, TX 78234 USA. [Chavko, Mikulas] US Naval Med Res Ctr, NeuroTrauma Dept, Silver Spring, MD 20910 USA. [Li, Yansong; Lucca, Jurandir J. Dalle] US Army Inst Surg Res, Immunomodulat Trauma Program, Jbsa Fort Sam Houston, TX 78234 USA. RP Wang, HCH (reprint author), US Army Inst Surg Res, Ocular Trauma Task Area, 3698 Chambers Pass,Bldg 3611, Jbsa Fort Sam Houston, TX 78234 USA. FU National Research Council; U.S. Army Military Operational Medicine Research Program; Clinical and Rehabilitative Medicine Research Program; Defense Medical Research and Development Program FX H-CW participated in study design, sample acquisition, contributed to data interpretation, and provided experimental supplies, equipment, and critical input into the article. J-HC participated in sample acquisition, processing, and analysis of data. WAG contributed to data interpretation, data acquisition, and drafted the article. MLP and HEC participated in sample acquisition, processing, and data acquisition. MC participated in study design and sample acquisition. YL participated in sample acquisition. JJDL participated in study design and sample acquisition. AJJ provided critical input into the article. All authors read and approved the final article. The authors J-HC and WAG are supported by the National Research Council Postdoctoral Fellowship. This work was supported by U.S. Army Military Operational Medicine Research Program, Clinical and Rehabilitative Medicine Research Program, and Defense Medical Research and Development Program. NR 14 TC 4 Z9 5 U1 3 U2 7 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD AUG PY 2014 VL 179 IS 8 SU S SI SI BP 34 EP 40 DI 10.7205/MILMED-D-13-00504 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UP UT WOS:000340806800009 PM 25102547 ER PT J AU McGhee, LL Maani, CV Garza, TH Slater, TM Petz, LN Fowler, M AF McGhee, Laura L. Maani, Christopher V. Garza, Thomas H. Slater, Terry M. Petz, Lawrence N. Fowler, Marcie TI The Intraoperative Administration of Ketamine to Burned US Service Members Does Not Increase the Incidence of Post-Traumatic Stress Disorder SO MILITARY MEDICINE LA English DT Article ID PAIN MANAGEMENT; INJURY PAIN; ANALGESIA; MORPHINE; IRAQ; AFGHANISTAN; ANESTHESIA; TRAUMA; CARE; PREVALENCE AB Aim: Patients with severe burns typically undergo multiple surgeries, and ketamine is often used as part of the multimodal anesthetic regimen during such surgeries. The anesthetic ketamine is an N-methyl-D-aspartate receptor antagonist that also provides analgesia at subanesthetic doses, but the psychoactive side effects of ketamine have caused concern about its potential psychological effects on a combat-wounded population. Post-traumatic stress disorder (PTSD) affects approximately 30% of burned U.S. service members injured in Operation Iraqi Freedom/Operation Enduring Freedom. A preliminary analysis by our research group reported that patients who received perioperative ketamine had a significantly lower prevalence of PTSD than those injured service members who did not receive ketamine. We have now expanded this research to examine the relationship between ketamine and PTSD development in a much larger population. Methods: A retrospective analysis on data from service members being treated for burns at the San Antonio Military Medical Center was conducted. Collected data included drugs received, injury severity score (ISS), total body surface area (TBSA) burned, length of hospital stay (LOS), number of intensive care unit days, number of surgeries, and PTSD Checklist-Military (PCL-M) scores and administration dates. Subjects were grouped based on intraoperative receipt of ketamine, and the groups were compared. The groups were binary for ketamine (yes or no), and dose of ketamine administered was not included in data analyses. Propensity score matching based on ISS and TBSA was performed to control for individual differences in burn severity. Results: Two hundred eighty-nine burned U.S. service members received the PCL-M at least 30 days after injury. Of these subjects, 189 received intraoperative ketamine, and 100 did not. Despite significantly greater injuries, as evidenced by significantly higher TBSA burned and ISS (p < 0.01), patients who received ketamine did not screen positive for PTSD at a different rate than those patients who did not (24% vs. 26.98%, p = 0.582). Patients receiving intraoperative ketamine also underwent a significantly greater number of surgeries, spent more time in the hospital, spent more days in the ICU, and received more morphine equivalent units (p < 0.0001). Propensity score matching based on ISS and TBSA resulted in a total subject number of 130. In the matched samples, subjects who received ketamine still underwent significantly more surgeries and experienced longer hospital stays (p < 0.0001). Again, there was no statistically significant difference in the incidence of a positive screen for PTSD based upon the receipt of ketamine (28% vs. 26.15%, p = 0.843). Conclusions: Ketamine is often used in burn patients to reduce opioid usage and decrease the hemodynamic and respiratory side effects. Although this study does not show a benefit of ketamine on PTSD development that was identified in previous work with a smaller sample number, it does support the conclusion that ketamine does not increase PTSD development in burned service members. C1 [McGhee, Laura L.; Garza, Thomas H.; Slater, Terry M.; Petz, Lawrence N.; Fowler, Marcie] US Army Inst Surg Res, Ft Sam Houston, TX 78239 USA. [Maani, Christopher V.] Brooke Army Med Ctr, Dept Anesthesia & Operat Serv, Ft Sam Houston, TX 78234 USA. RP McGhee, LL (reprint author), US Army Inst Surg Res, 3698 Chambers Pass,Bldg 3611, Ft Sam Houston, TX 78239 USA. FU U.S. Army Institute of Surgical Research Battlefield Pain Control Task Area; U.S. Army Medical Research and Materiel Command Combat Casualty Program; Clinical and Rehabilitative Medicine Research Program FX The authors acknowledge Mr. John Jones, USAISR statistician, for assistance in statistical analyses and data interpretation. This study was funded by the U.S. Army Institute of Surgical Research Battlefield Pain Control Task Area and the U.S. Army Medical Research and Materiel Command Combat Casualty and Clinical and Rehabilitative Medicine Research Programs. NR 41 TC 4 Z9 5 U1 1 U2 6 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD AUG PY 2014 VL 179 IS 8 SU S SI SI BP 41 EP 46 DI 10.7205/MILMED-D-13-00481 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UP UT WOS:000340806800010 PM 25102548 ER PT J AU Langworthy, MJ Nelson, F Owens, BD AF Langworthy, Michael J. Nelson, Fred Owens, Brett D. TI Viscosupplementation for Treating Osteoarthritis in the Military Population SO MILITARY MEDICINE LA English DT Review ID NONSTEROIDAL ANTIINFLAMMATORY DRUGS; RANDOMIZED CONTROLLED-TRIAL; ANTERIOR CRUCIATE LIGAMENT; KNEE OSTEOARTHRITIS; HYALURONIC-ACID; HYLAN G-F-20; INTRAARTICULAR HYALURONAN; CARTILAGE DEGRADATION; OARSI RECOMMENDATIONS; METABOLIC SYNDROME AB Military personnel have a greater risk of developing osteoarthritis (OA) than the general population. OA is a chronic, painful, and debilitating disease with a high cost burden. Compared with the general population, a higher prevalence of post-traumatic OA has been reported in the military. Using recent literature, we aim to improve the understanding of post-traumatic OA, with an exploration of the pathophysiology of OA. Our review encompasses the current treatment modalities for alleviating the pain from OA with a focus on viscosupplementation. A multimodal approach may be beneficial for the relief of OA pain and improvement of function in military personnel with early OA, and may lower the cost burden. C1 [Langworthy, Michael J.] Southcoast Hlth Syst, New Bedford, MA 02740 USA. [Nelson, Fred] Henry Ford Hosp, Dept Orthopaed, San Clemente, CA 92672 USA. [Owens, Brett D.] Keller Army Hosp, USUHS, West Point, NY 10996 USA. RP Langworthy, MJ (reprint author), Southcoast Hlth Syst, 101 Page St, New Bedford, MA 02740 USA. FU Sanofi Biosurgery FX Medical writing support was provided by Susan Bijur, PhD of Precise Publications, LLC, which was funded by Sanofi Biosurgery. NR 54 TC 0 Z9 0 U1 0 U2 6 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD AUG PY 2014 VL 179 IS 8 BP 815 EP 820 DI 10.7205/MILMED-D-14-00052 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UO UT WOS:000340806700002 PM 25102523 ER PT J AU Dabbs, C Watkins, EY Fink, DS Eick-Cost, A Milliken, AM AF Dabbs, Clifton Watkins, Eren Youmans Fink, David S. Eick-Cost, Angelia Milliken, Amy M. TI Opiate-Related Dependence/Abuse and PTSD Exposure Among the Active-Component US Military, 2001 to 2008 SO MILITARY MEDICINE LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; PERSIAN-GULF-WAR; SUBSTANCE USE DISORDERS; MENTAL-HEALTH PROBLEMS; DRUG DISORDERS; VETERANS; IRAQ; AFGHANISTAN; ILLNESS; ABUSE AB Background: Over the past 5 years, diagnoses for opiate abuse or dependency and post-traumatic stress disorder (PTSD) have increased across all U.S. military services. Moreover, in the United States, opiate prescription dependence and abuse has now surpassed all other illicit drugs of abuse with the exception of marijuana. Some research indicates that PTSD is predictive of substance dependence and abuse, while other research suggests that substance dependence and abuse may lead to events that trigger PTSD. This dichotomy has not been extensively explored within a military population. Methods: Using conditional multiple logistic regression analysis, a matched case control study with 18,606 active-component U.S. military service members was conducted to examine the relationship between opiate dependence or abuse and PTSD. Results: Among the 18,606 service members included in the analysis, 21% were cases and 79% were controls. Thirteen percent of service members with substance dependence or abuse diagnosis had a prior PTSD diagnosis compared to 1% of controls. After, adjusting for sociodemographic and military characteristics, the odds of having a prior diagnosis of PTSD was 28 (95% CI: 21.24-37.78) times greater for service members with opiate abuse/dependency compared to controls. Conclusion: These findings suggest active duty military personnel diagnosed with PTSD should be closely monitored to reduce the likelihood of future morbidity because of opiate dependence or abuse. C1 [Dabbs, Clifton] Walter Reed Army Inst Res, Dept Prevent Med, Bel Air, MD 21015 USA. [Watkins, Eren Youmans; Fink, David S.; Milliken, Amy M.] Army Inst Publ Hlth, Behav & Social Hlth Outcomes Program, Aberdeen Proving Ground, MD 21010 USA. [Eick-Cost, Angelia] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD 21090 USA. RP Dabbs, C (reprint author), Walter Reed Army Inst Res, Dept Prevent Med, 621 Derringer, Bel Air, MD 21015 USA. NR 42 TC 2 Z9 2 U1 3 U2 13 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD AUG PY 2014 VL 179 IS 8 BP 885 EP 890 DI 10.7205/MILMED-D-14-00012 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UO UT WOS:000340806700010 PM 25102531 ER PT J AU Walker, MR Kallingal, GJS Musser, JE Folen, R Stetz, MC Clark, JY AF Walker, Marc R. Kallingal, George J. S. Musser, John E. Folen, Raymond Stetz, Melba C. Clark, Joseph Y. TI Treatment Efficacy of Virtual Reality Distraction in the Reduction of Pain and Anxiety During Cystoscopy SO MILITARY MEDICINE LA English DT Article ID FLEXIBLE CYSTOSCOPY AB Objective: Assessment of virtual reality (VR) distraction for alleviating pain and anxiety during flexible cystoscopy. Cystoscopy is a common ambulatory procedure performed in Urology and can be associated with moderate pain and anxiety. Sophisticated distraction techniques are not used with cystoscopy and VR has not been studied for this procedure. We designed a prospective, randomized, controlled trial assessing the efficacy of VR for alleviating pain and anxiety during flexible cystoscopy. Methods: Adult men referred for cystoscopy were randomized into a control or VR group. Subjects were given preprocedure and postprocedure questionnaires addressing anxiety, pain, and time spent thinking about pain. Vitals signs and galvanic skin monitors were used as objective measures. The control group underwent routine cystoscopy and the VR group underwent cystoscopy with VR. Physicians answered a postprocedure questionnaire assessing the difficulty of the exam. All questionnaires used a visual analog score for assessment. Results: 23 patients enrolled in the control group and 22 in the VR group. Mean scores and Student's t-test were employed to analyze the data. No data endpoints showed a statistically significant difference between the 2 groups. Conclusions: We concluded no benefit to VR distraction mitigating pain in male patients during cystoscopy. C1 [Walker, Marc R.; Kallingal, George J. S.; Musser, John E.; Folen, Raymond; Stetz, Melba C.; Clark, Joseph Y.] Tripler Army Med Ctr, Honolulu, HI 96850 USA. RP Walker, MR (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96850 USA. NR 14 TC 2 Z9 2 U1 1 U2 6 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD AUG PY 2014 VL 179 IS 8 BP 891 EP 896 DI 10.7205/MlLMED-D-13-00343 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UO UT WOS:000340806700011 PM 25102532 ER PT J AU Piche, BM Stankorb, SM Salgueiro, M AF Piche, Brittney M. Stankorb, Susan M. Salgueiro, Marybeth TI Attitudes, Beliefs, and Behaviors of Active Duty Soldiers Attending the ArmyMOVE! Weight Management Program SO MILITARY MEDICINE LA English DT Article ID SELF-PERCEPTION; US ARMY; OVERWEIGHT; OBESITY; CONSUMPTION; PREVALENCE; EXERCISE; FITNESS; WOMEN AB Introduction: The objective of this study was to assess the attitudes, beliefs, and behaviors of Active Duty Soldiers attending the ArmyMOVE! (AM!) weight management program at three locations in Texas. Methods: A 40-question survey on weight-loss attitudes, beliefs, and behaviors was administered to participants before receiving the AM! education. Results: The response rate was 82.8% (n = 312). The sample was predominantly obese (64.3%), male (81.7%), and enlisted (95.3%). Only 30% were able to correctly identify their weight status using body mass index. The majority felt that weight standards were achievable (47%) and were confident in their ability to make diet (88.8%) and exercise (87.5%) changes; though most felt the tape test was not an accurate measure of body composition (71.5%). Soldiers reported using suboptimal weight-loss behaviors including diet pills (48.7%), sweat suits/saunas (44.9%), fasting (45.3%), and herbal supplements (31.1%), whereas the majority were not achieving proven recommendations for weight loss including adequate fruit (57%) and vegetable (93%) intake and adequate sleep duration (80%). Conclusion: This survey demonstrated AM! participants are using suboptimal methods of weight loss, few are following the Army Surgeon General's guidelines for nutrition and sleep, and an increased intensity of the AM! program is desired by the participants. C1 [Piche, Brittney M.; Stankorb, Susan M.; Salgueiro, Marybeth] Brooke Army Med Ctr, Dept Med Nutr, Ft Sam Houston, TX 78234 USA. RP Piche, BM (reprint author), Brooke Army Med Ctr, Dept Med Nutr, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 37 TC 1 Z9 1 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD AUG PY 2014 VL 179 IS 8 BP 906 EP 912 DI 10.7205/MILMED-D-13-00498 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UO UT WOS:000340806700014 PM 25102535 ER PT J AU Boyle, EW AF Boyle, Eric W. TI World War I Medical Films and Photography SO MILITARY MEDICINE LA English DT Editorial Material C1 US Army Med Res & Mat Command, Natl Museum Hlth & Med, Silver Spring, MD 20910 USA. RP Boyle, EW (reprint author), US Army Med Res & Mat Command, Natl Museum Hlth & Med, 2500 Linden Lane, Silver Spring, MD 20910 USA. NR 3 TC 0 Z9 0 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD AUG PY 2014 VL 179 IS 8 BP 933 EP 934 DI 10.7205/MILMED-D-14-00186 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UO UT WOS:000340806700018 PM 25102539 ER PT J AU Wu, ZZ Han, XG Zheng, JX Wei, Y Qiao, RM Shen, F Dai, JQ Hu, LB Xu, K Lin, Y Yang, WL Pan, F AF Wu, Zhongzhen Han, Xiaogang Zheng, Jiaxin Wei, Yi Qiao, Ruimin Shen, Fei Dai, Jiaqi Hu, Liangbing Xu, Kang Lin, Yuan Yang, Wanli Pan, Feng TI Depolarized and Fully Active Cathode Based on Li(Ni0.5Co0.2Mn0.3)O-2 Embedded in Carbon Nanotube Network for Advanced Batteries SO NANO LETTERS LA English DT Article DE Depolarization; fill-active cathode; low functionalized CNT; NCM523; capacity; delithiation kinetic ID LITHIUM-ION BATTERIES; ELECTRODES; LINI1/3CO1/3MN1/3O2; PERFORMANCE; CHEMISTRY; GRAPHITE AB Improving battery capacity and power is a daunting challenge, and in Li-ion batteries positive electrodes often set the limitation on both properties. Layered transition-metal oxides have. served as the mainstream cathode materials for high-energy batteries due to their large theoretical capacity (similar to 280 mAh/g). Here we report a significant enhancement of cathode capacity utilization through a novel concept of material design. By embedding Li(Ni0.5Co0.2Mn0.3)O-2 in the single wall carbon nanotube (CNT) network, we created a composite in which all components are electrochemically active. Long-term charge/discharge stability was obtained between 3.0 and 4.8 V, and both Li(Ni0.5Co0.2Mn0.3)O-2 and CNT contribute to the overall reversible capacity by 250 and 50 mAh/g, respectively. The observed improvement causes significant depolarization within the electrodes through the CNT network system. Additionally, the depolarization provides the ideal template to understand the solid reaction mechanism of Li(Ni0.5Co0.2Mn0.3)O-2 by demonstrating well-defined two-stage delithiation kinetics consistent with first-principle calculations, which would be otherwise impossible. These results deliver new insights on both practical designs and fundamental understandings of battery cathodes. C1 [Wu, Zhongzhen; Zheng, Jiaxin; Wei, Yi; Lin, Yuan; Pan, Feng] Peking Univ, Shenzhen Grad Sch, Sch Adv Mat, Shenzhen 518055, Peoples R China. [Han, Xiaogang; Shen, Fei; Dai, Jiaqi; Hu, Liangbing] Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA. [Qiao, Ruimin; Yang, Wanli] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Adv Light Source, Berkeley, CA 94720 USA. [Xu, Kang] US Army Res Lab, Adelphi, MD 20783 USA. RP Pan, F (reprint author), Peking Univ, Shenzhen Grad Sch, Sch Adv Mat, Shenzhen 518055, Peoples R China. EM panfeng@pkusz.edu.cn RI Yang, Wanli/D-7183-2011; Qiao, Ruimin/E-9023-2013; Hu, Liangbing/N-6660-2013; Han, Xiaogang/D-6430-2015; lin, yuan/G-9390-2013 OI Yang, Wanli/0000-0003-0666-8063; Han, Xiaogang/0000-0002-4785-6506; lin, yuan/0000-0003-3410-3588 FU Shenzhen Science and Technology Research [ZDSY20130331145131323, SGLH20120928095706623, CXZZ20120829172325895, JCYJ20120614150338154]; ShenZhen National SuperComputing Center FX This work was financially supported jointly by Shenzhen Science and Technology Research Grant (No. ZDSY20130331145131323, SGLH20120928095706623, CXZZ20120829172325895, and JCYJ20120614150338154). Additionally, we acknowledge the support of ShenZhen National SuperComputing Center and Daikin America who provided gratis the baseline high voltage electrolyte (without HFiP). NR 33 TC 33 Z9 33 U1 15 U2 143 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1530-6984 EI 1530-6992 J9 NANO LETT JI Nano Lett. PD AUG PY 2014 VL 14 IS 8 BP 4700 EP 4706 DI 10.1021/nl5018139 PG 7 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA AN2WH UT WOS:000340446200078 PM 24979204 ER PT J AU Lazarus, N Meyer, CD Bedair, SS Nochetto, H Kierzewski, IM AF Lazarus, N. Meyer, C. D. Bedair, S. S. Nochetto, H. Kierzewski, I. M. TI Multilayer liquid metal stretchable inductors SO SMART MATERIALS AND STRUCTURES LA English DT Article DE inductors; stretchable electronics; liquid metal; galinstan; fluidics ID SPIRAL INDUCTORS; ELECTRONICS; CONDUCTORS; GOLD AB Liquid metals are ideally suited for creating low resistance traces able to undergo large mechanical strains. In this work, multilayer fluidic channels in soft silicone are used to create two inductor topologies, a solenoid and a double planar coil, based on the liquid metal galinstan. Electromechanical models were developed for the inductance upon stretching for each inductor, finding that the double planar coil has lower strain sensitivity in each direction than the solenoid. A three turn double planar coil and six turn solenoid, with unstretched inductances of approximately 250 nH and 55 nH respectively, were fabricated and tested using custom tensile and compressive strain testing setups and compared with the analytical model. The double planar coil was found to increase in inductance when stretched in either in-plane axes, with a measured rise of approximately 40% for 100% strain. The solenoid decreased in inductance by 24% for 100% strain along the core direction, and increased by 50% for the same strain along the core width. C1 [Lazarus, N.] US Army Res Lab, Oak Ridge Assoc Univ Fellowship Program, Adelphi, MD 20783 USA. [Meyer, C. D.; Bedair, S. S.] US Army Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. [Nochetto, H.; Kierzewski, I. M.] Gen Tech Serv LLC, Trenton, NJ 07719 USA. RP Lazarus, N (reprint author), US Army Res Lab, Oak Ridge Assoc Univ Fellowship Program, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM nathan.lazarus2.ctr@mail.mil FU Army Research Laboratory FX This work was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-12-2-0019. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the US Government. The US Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 27 TC 10 Z9 10 U1 4 U2 15 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0964-1726 EI 1361-665X J9 SMART MATER STRUCT JI Smart Mater. Struct. PD AUG PY 2014 VL 23 IS 8 AR 085036 DI 10.1088/0964-1726/23/8/085036 PG 10 WC Instruments & Instrumentation; Materials Science, Multidisciplinary SC Instruments & Instrumentation; Materials Science GA AO0SH UT WOS:000341021600036 ER PT J AU Pruitt, BA AF Pruitt, Basil A., Jr. TI Reflection Evolution of the Field over Seven Decades SO SURGICAL CLINICS OF NORTH AMERICA LA English DT Article DE Burns; Fluid resuscitation; Inhalation injury; Burn wound care; Metabolic response to injury; Organization of burn care and research ID INHALATION INJURY; THERMAL-INJURY; BURN PATIENTS; SMOKE-INHALATION; GROWTH-HORMONE; CHILDREN; CATECHOLAMINES; RESUSCITATION; MORTALITY; PROGRESS AB Marked expansion of physiologic understanding and the improvement of burn patient outcomes have resulted from multidisciplinary clinical/laboratory research programs at burn centers in the United States and elsewhere. C1 [Pruitt, Basil A., Jr.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Pruitt, BA (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA. EM pruitt@uthscsa.edu NR 53 TC 1 Z9 1 U1 0 U2 4 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0039-6109 EI 1558-3171 J9 SURG CLIN N AM JI Surg. Clin.-North Am. PD AUG PY 2014 VL 94 IS 4 BP 721 EP + DI 10.1016/j.suc.2014.05.001 PG 21 WC Surgery SC Surgery GA AO2CN UT WOS:000341123200003 PM 25085084 ER PT J AU Cancio, LC AF Cancio, Leopoldo C. TI Initial Assessment and Fluid Resuscitation of Burn Patients SO SURGICAL CLINICS OF NORTH AMERICA LA English DT Article DE Burns; Inhalation injury; Resuscitation ID SMOKE-INHALATION INJURY; THERMAL-INJURY; MILITARY CASUALTIES; OUTCOMES AB For the physician or surgeon practicing outside the confines of a burn center, initial assessment and fluid resuscitation will encompass most of his or her exposure to patients with severe burns. The importance of this phase of care should not be underestimated. This article provides a review of how to perform initial resuscitation of patients with significant burns and/or inhalation injury, while arranging for transfer to a regional burn center. C1 US Army, Inst Surg Res, JBSA, Med Corps, Ft Sam Houston, TX 78234 USA. RP Cancio, LC (reprint author), US Army, Inst Surg Res, JBSA, Med Corps, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM divego99@gmail.com FU Percussionaire, Inc. FX The author is a coinventor of Burn Resuscitation Decision Support Software (Burn Navigator), which has been licensed by the US Army to Arcos, Inc. for commercial production. The author has assigned his rights to the US Army, but would receive a small percentage of any royalties. He has received payment for travel expenses from Percussionaire, Inc. NR 36 TC 5 Z9 5 U1 0 U2 5 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0039-6109 EI 1558-3171 J9 SURG CLIN N AM JI Surg. Clin.-North Am. PD AUG PY 2014 VL 94 IS 4 BP 741 EP + DI 10.1016/j.suc.2014.05.003 PG 15 WC Surgery SC Surgery GA AO2CN UT WOS:000341123200004 PM 25085085 ER PT J AU Ivashchenko, VI Veprek, S Turchi, PEA Shevchenko, VI Leszczynski, J Gorb, L Hill, F AF Ivashchenko, V. I. Veprek, S. Turchi, P. E. A. Shevchenko, V. I. Leszczynski, J. Gorb, L. Hill, F. TI First-principles molecular dynamics investigation of thermal and mechanical stability of the TiN(001)/AlN and ZrN(001)/AIN heterostructures SO THIN SOLID FILMS LA English DT Article DE Superhard TiN- and ZrN-based heterostructures; Nanocomposites; First-principles molecular dynamics; Dynamic stability; Ideal strength; Stress-strain relationships ID AB-INITIO; COATINGS; DECOMPOSITION; PSEUDOPOTENTIALS; TI1-XALXN; SYSTEM; ALN AB First-principles quantum molecular dynamics investigations of TiN(001)/AlN and ZrN(001)/AIN heterostructures with one and two monolayers (1 ML and 2 ML) of AIN interfacial layers were carried out in the temperature range of 0-1400 K with subsequent static relaxation. It is shown that the epitaxially stabilized cubic B1-AIN interfacial layers are preserved in all TiN(001)/AIN heterostructures over the whole temperature range. In the ZrN(001)/AlN heterostructures, the B1-AIN(001) interfacial layer exists at 0 K, but it transforms into a distorted one at 10 K consisting of tetrahedral AlN4, octahedral AIN6, and AIN5 units. The thermal stability of the interfaces was investigated by studying the phonon dynamic stability of the B1-AlN phase with different lattice parameters. The calculations showed that the B1-AIN interface should be unstable in ZrN(001)/AIN heterostructures and nanocomposites, and in those based on transition metal nitrides with lattice parameters larger than 4.4 A. Electronic band structure calculations showed that energy gap forms around the Fermi energy for all interfaces. The formation of the interfacial AIN layer in TiN and ZrN crystals reduces their ideal tensile and shear strengths. Upon tensile load, decohesion occurs between Ti (Zr) and N atoms adjacent to the 1 MLAIN interfacial layer, whereas in the case of 2 ML AIN it occurs inside the TiN and ZrN slabs. The experimentally reported strength enhancement in the TiN/AIN and ZrN/AlN heterostructures is attributed to impeding effect of the interfacial layer on the plastic flow. (C) 2014 Elsevier B.V. All rights reserved. C1 [Ivashchenko, V. I.; Shevchenko, V. I.] Natl Acad Sci Ukraine, Inst Problems Mat Sci, UA-03142 Kiev, Ukraine. [Veprek, S.] Tech Univ Munich, Dept Chem, D-85747 Garching, Germany. [Turchi, P. E. A.] Lawrence Livermore Natl Lab L 352, Livermore, CA 94551 USA. [Leszczynski, J.; Gorb, L.] Jackson State Univ, Interdisciplinary Ctr Nanotox, Dept Chem & Biochem, Jackson, MS 39217 USA. [Gorb, L.; Hill, F.] US Army ERDC, Vicksburg, MS 39180 USA. RP Ivashchenko, VI (reprint author), Natl Acad Sci Ukraine, Inst Problems Mat Sci, Krzhyzhanosky Str 3, UA-03142 Kiev, Ukraine. EM ivash@ipms.kiev.ua; stan.veprek@lrz.tum.de RI Veprek, Stan/C-1248-2008 OI Veprek, Stan/0000-0002-6016-3093 FU STCU [5539]; U.S. Department of Energy; Lawrence Livermore National Laboratory [DE-AC52-07NA27344] FX This work was supported by the STCU contract no. 5539. The work of P.T. was performed under the auspices of the U.S. Department of Energy by the Lawrence Livermore National Laboratory under contract no. DE-AC52-07NA27344. The authors are grateful to the directorate of the Summery Institute at Jackson State University for financial support and the possibility to perform large-scale calculations. S.V. thanks SHM Company NR 37 TC 4 Z9 4 U1 3 U2 33 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0040-6090 J9 THIN SOLID FILMS JI Thin Solid Films PD AUG 1 PY 2014 VL 564 BP 284 EP 293 DI 10.1016/j.tsf.2014.05.036 PG 10 WC Materials Science, Multidisciplinary; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA AN8KD UT WOS:000340852200039 ER PT J AU Crawford, KW Wakabi, S Kibuuka, H Magala, F Keshinro, B Okoye, I Akintunde, E Hamm, TE AF Crawford, Keith W. Wakabi, Salim Kibuuka, Hannah Magala, Fred Keshinro, Babajide Okoye, Ifeanyi Akintunde, Ezekiel Hamm, Tiffany E. TI Short Communication: East Meets West: A Description of HIV-1 Drug Resistance Mutation Patterns of Patients Failing First Line Therapy in PEPFAR Clinics from Uganda and Nigeria SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID ANTIRETROVIRAL THERAPY; REVERSE-TRANSCRIPTASE; VIROLOGICAL RESPONSE; GENOTYPIC RESISTANCE; FAILURE; TYPE-1; SUSCEPTIBILITY; INDIVIDUALS; PREDICTORS; EMERGENCE AB HIV-1 viral load (VL) monitoring is recommended but seldom performed in resource-constrained countries. An evaluation of patients receiving first-line antiretroviral therapy in a multicountry PEPFAR program (RV288) was performed to determine the rates and predictors of virologic suppression. Resistance data from treatment failures are available from Uganda and Nigeria. Each country enrolled 325 subjects into this cross-sectional study. Subjects on first-line therapy were randomly selected for HIV RNA testing (viral load). Regimens included efavirenz or nevirapine with zidovudine/lamivudine or tenofovir/lamivudine. VL was determined from plasma using the Roche COBAS TaqMan HIV-1 Test, High Pure System v1.0 (47 copies/ml). Genotypic resistance testing was performed on samples with VL > 1,000 copies/ml. From Uganda, 85% of subjects were undetectable while 7%(23/325) had VL > 1,000 copies/ml. The HIV-1 subtype distribution was as follows: A = 47.6%, C = 14.3%, and D = 38.1%. No resistance mutations were found in 14% of subjects. All subjects with resistance had the M184V mutation. Of subjects failing a zidovudine regimen less than 1 year, 88% (7/8) had no thymidine analogue mutations (TAMs), compared to 50% (4/8) failing greater than 1 year. Four subjects (25%) hadmore than two mutations from the TAM-1pathway (41L, 210W, 215Y). In Nigeria, 82% were undetectable while 14% (45/325) had VL > 1,000 copies/ml. HIV-1 subtype distribution was as follows: 62.8% = CRF02_AG, 34% = pure G, and 2.8% = A. Of the 35 genotyped subjects, 14% (5/35) had no resistance mutations. Of the remainder, 10% (3/30) had no nucleoside analogue mutations while 33% (10/30) had only M184V along with nonnucleoside reverse transcriptase inhibitor (NNRTI) mutations. Forty percent (10/25) of subjects on zidovudine failed without TAMs. Another 25% (5/25) of subjects failing on zidovudine had more than two TAM-1 mutations. Individuals failing first-line antiretroviral therapy (ART) may retain sensitivity to one or more nucleoside analogues from the regimen. Knowledge of drug resistance patterns allow for selection of drugs that can be recycled in future regimens. Accumulation of resistance mutations may compromise future treatment options. C1 [Crawford, Keith W.; Hamm, Tiffany E.] Walter Reed Army Inst Res, Global Hlth Programs, US Mil HIV Res Program MHRP, Bethesda, MD 20817 USA. [Wakabi, Salim; Kibuuka, Hannah; Magala, Fred] MUWRP, Kampala, Uganda. [Keshinro, Babajide; Okoye, Ifeanyi; Akintunde, Ezekiel] Nigeria Walter Reed Program, Abuja, Nigeria. RP Crawford, KW (reprint author), Walter Reed Army Inst Res, Global Hlth Programs, US Mil HIV Res Program MHRP, 6720A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA. EM kwcrawford1@gmail.com FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DoD) [W81XWH-07-2-0067] FX This work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. and the U.S. Department of Defense (DoD). The views expressed are those of the authors and should not be construed to represent the positions of the U.S. Army or DoD. NR 19 TC 1 Z9 1 U1 0 U2 3 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD AUG PY 2014 VL 30 IS 8 BP 796 EP 799 DI 10.1089/aid.2013.0294 PG 4 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AN4DX UT WOS:000340538900011 PM 24798614 ER PT J AU Marks, CE Glen, AG Robinson, MW Leemis, LM AF Marks, Christopher E. Glen, Andrew G. Robinson, Matthew W. Leemis, Lawrence M. TI Applying Bootstrap Methods to System Reliability SO AMERICAN STATISTICIAN LA English DT Article DE Bias; Bootstrapping; Parametric lifetime distributions AB We present a fully enumerated bootstrap method to find the empirical system lifetime distribution for a coherent system modeled by a reliability block diagram. Given failure data for individual components of a coherent system, the bootstrap empirical system lifetime distribution derived here will be free of resampling error. We further derive distribution-free expressions for the bias associated with the bootstrap method for estimating the mean system lifetimes of parallel and series systems with statistically identical components. We show that bootstrapping underestimates the mean system lifetime for parallel systems and overestimates the mean system lifetime for series systems, although both bootstrap estimates are asymptotically unbiased. The expressions for the bias are evaluated for several popular parametric lifetime distributions. Supplementary materials for this article are available online. C1 [Marks, Christopher E.; Glen, Andrew G.] US Mil Acad, West Point, NY 10996 USA. [Robinson, Matthew W.] US Army, Washington, DC USA. [Leemis, Lawrence M.] Coll William & Mary, Dept Math, Williamsburg, VA 23187 USA. RP Marks, CE (reprint author), US Mil Acad, West Point, NY 10996 USA. EM cemarks@nps.edu; Andrew.Glen.1984@gmail.com; mthw.wm.robinson@gmail.com; leemis@math.wm.edu NR 10 TC 0 Z9 3 U1 0 U2 3 PU AMER STATISTICAL ASSOC PI ALEXANDRIA PA 732 N WASHINGTON ST, ALEXANDRIA, VA 22314-1943 USA SN 0003-1305 EI 1537-2731 J9 AM STAT JI Am. Stat. PD AUG PY 2014 VL 68 IS 3 BP 174 EP 182 DI 10.1080/00031305.2014.928232 PG 9 WC Statistics & Probability SC Mathematics GA AN2NQ UT WOS:000340423000005 ER PT J AU Harmon, AR Kennedy, AJ Poda, AR Bednar, AJ Chappell, MA Steevens, JA AF Harmon, Ashley R. Kennedy, Alan J. Poda, Aimee R. Bednar, Anthony J. Chappell, Mark A. Steevens, Jeffery A. TI DETERMINATION OF NANOSILVER DISSOLUTION KINETICS AND TOXICITY IN AN ENVIRONMENTALLY RELEVANT AQUEOUS MEDIUM SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Silver nanoparticles; Dissolution kinetics; Ionic strength; Ecotoxicity effects ID COATED SILVER NANOPARTICLES; ION-RELEASE KINETICS; AGGREGATION KINETICS; BEHAVIOR; ECOTOXICITY; DISPERSION; STABILITY; EXPOSURE; NANOMATERIALS; MODEL AB Assessing the dissolution of silver nanoparticles (AgNPs) in laboratory test media and in the aquatic environment is critical for determining toxicity. In the present study, the ion-release kinetics for 20-nm, 50-nm, and 80-nm AgNPs in environmentally relevant freshwaters with different electrical conductivity values (30 mu S/cm, 150 mu S/cm) were examined and related to the associated impact on Daphnia magna. The acute toxicity of the AgNP suspensions to D. magna was assessed after 0 d and 7 d of interaction time between the particles and test media. When 48-h lethal median concentrations were expressed as total silver, D. magna was more sensitive to AgNPs suspended in low ionic strength media relative to higher ionic strength media, with the exception of 50-nm AgNPs suspended in the 150-mu S/cm medium. A 3.3-fold increase in hydrodynamic diameter measured by dynamic light scattering and field flow fractionation was observed over time for 20-nm particles in the 150-mS/cm medium, but only a small increase in aggregation size for 50-nm and 80-nm particles (1.4-fold and 1.2-fold increase, respectively) was observed. At a lower conductivity of 30 mu S/cm, a 1.7-fold, 1.0-fold, and 1.2-fold increase in aggregation size was observed in the 20-nm, 50-nm, and 80-nm particles, respectively. Thus, the impact of higher conductivity test media on increased aggregation and decreased toxicity (after 7 d) was relatively greater for the smaller (20-nm) AgNP higher compared to the 50-80 nm AgNPs. Environ Toxicol Chem 2014; 33: 1783-1791. Published 2014 Wiley Periodicals, Inc. This article is a US Government work and, as such, is in the public domain in the United States of America. C1 [Harmon, Ashley R.; Kennedy, Alan J.; Poda, Aimee R.; Bednar, Anthony J.; Chappell, Mark A.; Steevens, Jeffery A.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Harmon, AR (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. EM ashley.harmon@usace.army.mil RI Poda, Aimee/K-1905-2012 NR 36 TC 9 Z9 9 U1 3 U2 43 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD AUG PY 2014 VL 33 IS 8 BP 1783 EP 1791 DI 10.1002/etc.2616 PG 9 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA AN4DD UT WOS:000340536900016 PM 24753094 ER PT J AU Bruns, I Lucas, D Pinho, S Ahmed, J Lambert, M Kunisaki, Y Scheiermann, C Poncz, M Bergmann, A Frenette, P AF Bruns, Ingmar Lucas, Daniel Pinho, Sandra Ahmed, Jalal Lambert, Michele Kunisaki, Yuya Scheiermann, Christoph Poncz, Mortimer Bergmann, Aviv Frenette, Paul TI MEGAKARYOCYTES REGULATE HEMATOPOIETIC STEM CELL QUIESCENCE VIA CXCL4 SECRETION SO EXPERIMENTAL HEMATOLOGY LA English DT Meeting Abstract CT 43rd Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH) CY AUG 21-24, 2014 CL Montreal, CANADA SP Int Soc Expt Hematol C1 [Bergmann, Aviv] AECOM, Dept Syst & Computat Biol, New York, NY USA. [Bruns, Ingmar; Lucas, Daniel; Pinho, Sandra; Ahmed, Jalal; Kunisaki, Yuya; Scheiermann, Christoph; Frenette, Paul] AECOM, Ruth L & David S Gottesman Inst Stem Cell & Regen, New York, NY USA. [Lambert, Michele; Poncz, Mortimer] USA, Childrens Hosp Philadelphia, Dept Med, Philadelphia, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0301-472X EI 1873-2399 J9 EXP HEMATOL JI Exp. Hematol. PD AUG PY 2014 VL 42 IS 8 SU 1 MA O1025 BP S18 EP S18 PG 1 WC Hematology; Medicine, Research & Experimental SC Hematology; Research & Experimental Medicine GA AN1LF UT WOS:000340344300053 ER PT J AU Wang, D Al Amin, MT Abdelzaher, T Roth, D Voss, CR Kaplan, LM Tratz, S Laoudi, J Briesch, D AF Wang, Dong Al Amin, Md Tanvir Abdelzaher, Tarek Roth, Dan Voss, Clare R. Kaplan, Lance M. Tratz, Stephen Laoudi, Jamal Briesch, Douglas TI Provenance-Assisted Classification in Social Networks SO IEEE JOURNAL OF SELECTED TOPICS IN SIGNAL PROCESSING LA English DT Article DE Social signals; classification; uncertain provenance; maximum likelihood estimation; expectation maximization; signal feature extraction ID EM ALGORITHM AB Signal feature extraction and classification are two common tasks in the signal processing literature. This paper investigates the use of source identities as a common mechanism for enhancing the classification accuracy of social signals. We define social signals as outputs, such as microblog entries, geotags, or uploaded images, contributed by users in a social network. Many classification tasks can be defined on such outputs. For example, one may want to identify the dialect of a microblog contributed by an author, or classify information referred to in a user's tweet as true or false. While the design of such classifiers is application-specific, social signals share in common one key property: they are augmented by the explicit identity of the source. This motivates investigating whether or not knowing the source of each signal (in addition to exploiting signal features) allows the classification accuracy to be improved. We call it provenance-assisted classification. This paper answers the above question affirmatively, demonstrating how source identities can improve classification accuracy, and derives confidence bounds to quantify the accuracy of results. Evaluation is performed in two real-world contexts: (i) fact-finding that classifies microblog entries into true and false, and (ii) language classification of tweets issued by a set of possibly multi-lingual speakers. We also carry out extensive simulation experiments to further evaluate the performance of the proposed classification scheme over different problem dimensions. The results show that provenance features significantly improve classification accuracy of social signals, even when no information is known about the sources (besides their ID). This observation offers a general mechanism for enhancing classification results in social networks. C1 [Wang, Dong; Al Amin, Md Tanvir; Abdelzaher, Tarek; Roth, Dan] Univ Illinois, Dept Comp Sci, Urbana, IL 61801 USA. [Voss, Clare R.; Kaplan, Lance M.; Tratz, Stephen; Laoudi, Jamal; Briesch, Douglas] US Army Res Lab, Adelphi, MD 20783 USA. RP Wang, D (reprint author), Univ Illinois, Dept Comp Sci, Urbana, IL 61801 USA. EM dwang24@illinois.edu; maamin2@illinois.edu; zaher@illinois.edu; danr@illinois.edu; clare.r.voss.civ@mail.mil; lance.m.kaplan.civ@mail.mil; stephen.c.tratz.civ@mail.mil; jamal.laoudi.ctr@mail.mil; douglas.m.briesch.civ@mail.mil FU Army Research Laboratory; [W911NF-09-2-0053] FX This work was supported by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-09-2-0053. The guest editor coordinating the review of this manuscript and approving it for publication was Prof. Vikram Krishnamurthy. NR 27 TC 5 Z9 5 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1932-4553 EI 1941-0484 J9 IEEE J-STSP JI IEEE J. Sel. Top. Signal Process. PD AUG PY 2014 VL 8 IS 4 BP 624 EP 637 DI 10.1109/JSTSP.2014.2311586 PG 14 WC Engineering, Electrical & Electronic SC Engineering GA AN4AB UT WOS:000340528900011 ER PT J AU Liao, DH AF Liao, DaHan TI Scattering and Imaging of Nonlinearly Loaded Antenna Structures in Half-Space Environments SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Article DE Computational electromagnetics; harmonic balance; linear and nonlinear electromagnetic scattering; method-of-moments; multistatic radar imaging; radiowave propagation; remote sensing; subspace-based imaging ID MULTIPLE SIGNAL CLASSIFICATION; MOM-AOM APPROACH; FREQUENCY-DOMAIN; TRANSIENT-RESPONSE; EXTENDED TARGETS; HARMONIC RADAR; WIRE; ALGORITHMS; SYSTEMS; ARRAYS AB The electromagnetic scattering responses of nonlinearly loaded antenna structures excited by single-tone or multi-tone incident fields are considered in the frequency domain by employing a combination of the method-of-moments and a harmonic balance technique. Subsequently, standoff detection and localization of the scatterers in the presence of a half space is demonstrated with a subspace imaging procedure by exploiting the steady-state, multistatic harmonic scattering responses collected over an aspect-limited aperture. The attenuation rates of the harmonic scattered fields as a function of sensing range are investigated. The Green's function vector in the imaging functional is derived efficiently with the application of second-order-accurate asymptotic propagation techniques, and near-field imaging performance for single and multiple targets is also examined in the presence of noise and linear clutter. This study is intended to provide an analysis and simulation framework needed to facilitate the development of a complementary nonlinear detection capability for an existing near-ground, forward-looking linear imaging radar system. C1 US Army Res Lab, Adelphi, MD 20783 USA. RP Liao, DH (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM dahan.liao.civ@mail.mil NR 39 TC 1 Z9 1 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-926X EI 1558-2221 J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD AUG PY 2014 VL 62 IS 8 BP 4230 EP 4240 DI 10.1109/TAP.2014.2322875 PG 11 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA AN2XV UT WOS:000340450200035 ER PT J AU Brozena, A Buchanan, JH Miles, RW Williams, BR Hulet, MS AF Brozena, Ann Buchanan, James H. Miles, Ronald W., Jr. Williams, Barry R. Hulet, Melissa S. TI Vapor Pressure of Triethyl and Tri-n-Propyl Phosphates and Diethyl Malonate SO JOURNAL OF CHEMICAL AND ENGINEERING DATA LA English DT Article ID ORGANOPHOSPHORUS COMPOUNDS; TRIALKYL PHOSPHITES; CHEMICAL CONSTITUTION; PHOSPHORUS PENTOXIDE; CHLORAMINE-T; PART I; ESTERS; ACIDS; PHOSPHORYLATION; REACTIVITY AB Triethyl phosphate (TEPO, CAS No. 78-40-0), tri-n-propyl phosphate (TPPO, CAS No. 513-08-6), and diethyl malonate (DEM, CAS No. 105-53-3) are of considerable interest to the chemical defense community as nontoxic simulants for toxic chemical warfare agents. Vapor pressure data have been measured for TEPO at T = (271.25 to 480.15) K, for TPPO at T = (263.15 to 527.61) K, and for DEM at T = (265.15 to 471.25) K using a variety of standard methods that have been modified as necessary. The new data extend the range of vapor pressure data previously reported in the literature for each of the title compounds to subambient temperatures and to lower pressures by approximately 3 orders of magnitude for TEPO, 5 orders of magnitude for TPPO, and 1 order of magnitude for DEM. Vapor pressure data and derived properties, including volatility and temperature-dependent heats of vaporization are reported for TEPO, TPPO, and DEM along with comparisons to chemical warfare agent materials. C1 [Brozena, Ann; Buchanan, James H.; Miles, Ronald W., Jr.] US Army Res Dev & Engn Command, Edgewood Chem Biol Ctr, Aberdeen, MD 21010 USA. [Williams, Barry R.; Hulet, Melissa S.] Leidos Corp, Gunpowder, MD 21010 USA. RP Brozena, A (reprint author), US Army Res Dev & Engn Command, Edgewood Chem Biol Ctr, Aberdeen, MD 21010 USA. EM ann.brozena.civ@mail.mil NR 98 TC 2 Z9 2 U1 2 U2 14 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0021-9568 J9 J CHEM ENG DATA JI J. Chem. Eng. Data PD AUG PY 2014 VL 59 IS 8 BP 2649 EP 2659 DI 10.1021/je500428d PG 11 WC Thermodynamics; Chemistry, Multidisciplinary; Engineering, Chemical SC Thermodynamics; Chemistry; Engineering GA AN2UR UT WOS:000340442000038 ER PT J AU Pelaez, M Susin, C Lee, J Fiorini, T Bisch, FC Dixon, DR McPherson, JC Buxton, AN Wikesjo, UME AF Pelaez, Manuel Susin, Cristiano Lee, Jaebum Fiorini, Tiago Bisch, Frederick C. Dixon, Douglas R. McPherson, James C., III Buxton, Amanda N. Wikesjo, Ulf M. E. TI Effect of rhBMP-2 dose on bone formation/maturation in a rat critical-size calvarial defect model SO JOURNAL OF CLINICAL PERIODONTOLOGY LA English DT Article DE animal models; BMP-2; bone formation; bone maturation; calvarial bone; dose ID RICH PLASMA PREPARATION; MORPHOGENETIC PROTEIN-2; RIDGE AUGMENTATION; RADIOGRAPHIC OBSERVATIONS; REGENERATION; IMPLANTS; CARRIER; SYSTEM; DOGS AB Background: Application of recombinant human bone morphogenetic protein-2 (rhBMP-2) has been associated with significant adverse events in craniofacial settings, including swelling and seroma formation. Recent work has demonstrated an inverse relationship between bone formation/maturation and rhBMP-2 dose, frequency/severity of adverse events increasing with rising dose. Objective: The objective of this study was to determine the most effective dose for rhBMP-2 soak-loaded onto an absorbable collagen sponge (ACS) carrier for bone formation/maturation using an established defect model. Methods: One hundred sixty-eight outbred male Sprague-Dawley rats, age 11-13 weeks, weight 325-375 g randomized into seven groups of 24 subdivided into groups of eight, were used to provide radiographic and light microscopy observations of bone formation/maturation and aberrant healing events at 2, 4 and 8 weeks following application of rhBMP-2/ACS into critical-size, (sic)8-mm, through-through, calvarial osteotomy defects for a dose of 1.25, 2.5, 5.0, 10.0 and 20.0 mu g rhBMP-2/defect, or serve as ACS or sham-surgery controls. Results: rhBMP-2 dosages >= 2.5 mu g/defect showed histological defect closure >90% within 2 weeks, and complete resolution within 4 weeks. Adverse healing events including swelling, excessive bone formation or seroma formation could not be determined with certainty in this defect model. Notably ACS control sites showed complete defect closure at the 8-week healing interval. Conclusions: rhBMP-2/ACS accelerates local bone formation in the rat criticalsize through-through calvarial defect model once reaching an osteoinductive dose threshold. This threshold may already be reached at a 1.25-/2.5-mu g dose in this model. No further enhancement to bone formation/maturation may be observed adding rhBMP-2 above the 2.5-mu g dose. The 1.25-20.0 mu g dose range did not invoke appreciable aberrant healing events. C1 [Pelaez, Manuel; Susin, Cristiano; Lee, Jaebum; Fiorini, Tiago; Wikesjo, Ulf M. E.] Georgia Regents Univ, Coll Dent Med, LAPCR, Augusta, GA 30912 USA. [Pelaez, Manuel] US Army Dent Act, Ft Bragg, NC USA. [Fiorini, Tiago] Fed Univ, Sch Dent, Sect Periodontol, Porto Alegre, RS, Brazil. [Bisch, Frederick C.] US Army Adv Educ Program Periodont, Ft Gordon, GA USA. [Dixon, Douglas R.] US Army Dent Act, West Point, NY USA. [McPherson, James C., III] US Army, Dept Clin Invest, Ft Gordon, GA USA. [Buxton, Amanda N.] Medtron Spine & Biol, Memphis, TN USA. RP Wikesjo, UME (reprint author), Georgia Regents Univ, Coll Dent Med, LAPCR, 1120 Fifteenth St,GC 4265, Augusta, GA 30912 USA. EM uwikesjo@gru.edu RI Wikesjo, Ulf/A-4159-2009; Susin, Cristiano/B-9822-2008 OI Wikesjo, Ulf/0000-0003-1607-0583; FU Medtronic Spine & Biologics, Memphis, TN, USA; Nobel Biocare AG FX This study was supported in part by a grant from Medtronic Spine & Biologics, Memphis, TN, USA. Drs. Cristiano Susin, Jaebum Lee and Ulf M. E. Wikesjo are supported by a grant from Nobel Biocare AG. Dr. Amanda N. Buxton is an employee of Medtronic Spine & Biologics. All other authors claim no conflict of interest. The opinions expressed in this article do not represent the views of the US Department of Defense, the Department of the Army or the US Army Dental Corps. Use of any commercial products in this project does not imply endorsement by the US Government. NR 33 TC 10 Z9 10 U1 2 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0303-6979 EI 1600-051X J9 J CLIN PERIODONTOL JI J. Clin. Periodontol. PD AUG PY 2014 VL 41 IS 8 BP 827 EP 836 DI 10.1111/jcpe.12270 PG 10 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA AN4FI UT WOS:000340542600012 PM 24807100 ER PT J AU Ferguson, JB Tabandeh-Khorshid, M Mantas, JC Rohatgi, PK Cho, K Kim, CS AF Ferguson, J. B. Tabandeh-Khorshid, Meysam Mantas, John C. Rohatgi, Pradeep K. Cho, Kyu Kim, Chang-Soo TI Predicting the Effect of Pouring Temperature on the Crystallite Density, Remelting, and Crystal Growth Kinetics in the Solidification of Aluminum Alloys SO METALLURGICAL AND MATERIALS TRANSACTIONS B-PROCESS METALLURGY AND MATERIALS PROCESSING SCIENCE LA English DT Article ID GRAIN-REFINEMENT; SIZE AB In the present work, we developed an analytical model to describe the effect of pouring temperature on the crystallite density, remelting, growth kinetics, and the resultant final grain size for aluminum (Al)-based alloys synthesized using gravity casting. The model predicts that there are three regimes of pouring temperature/grain size-related behavior: (i) at low superheats, grain size is small and relatively constant; (ii) at intermediate levels of superheat, there appears to be a transitional behavior where grain size increases in a rapid, non-linear fashion; and (iii) at high superheats, grain size increases linearly with increasing temperature. This general pattern is expected to be shifted upward as distance from the bottom of the casting increases, which is likely a result of the slower cooling rates and/or longer solidification times with increasing distance from the bottom of the casting. To validate the model, a set of experiments has been conducted using Al-Cu and Al-Si alloys (i.e., Al-3.0 wt pct Cu, Al-4.5 wt pct Cu, and Al-A356.2 alloys), and the experimental measurements showed consistent results with theoretical predictions. C1 [Ferguson, J. B.; Tabandeh-Khorshid, Meysam; Mantas, John C.; Rohatgi, Pradeep K.; Kim, Chang-Soo] Univ Wisconsin, Mat Sci & Engn Dept, Milwaukee, WI 53211 USA. [Cho, Kyu] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen, MD 21005 USA. RP Ferguson, JB (reprint author), Univ Wisconsin, Mat Sci & Engn Dept, 3200 N Cramer St, Milwaukee, WI 53211 USA. EM kimcs@uwm.edu FU U.S. Army Research Laboratory [W911NF-08-2-0014] FX This material is based upon work supported by the U.S. Army Research Laboratory under Cooperative Agreement No. W911NF-08-2-0014. The views, opinions, and conclusions made in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of Army Research Laboratory or the U. S. Government. The U. S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 15 TC 2 Z9 3 U1 2 U2 12 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1073-5615 EI 1543-1916 J9 METALL MATER TRANS B JI Metall. Mater. Trans. B-Proc. Metall. Mater. Proc. Sci. PD AUG PY 2014 VL 45 IS 4 BP 1407 EP 1417 DI 10.1007/s11663-014-0044-9 PG 11 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA AN1SV UT WOS:000340364800026 ER PT J AU Jiang, RZ Tran, DT McClure, JP Chu, D AF Jiang, Rongzhong Tran, Dat T. McClure, Joshua P. Chu, Deryn TI A Class of (Pd-Ni-P) Electrocatalysts for the Ethanol Oxidation Reaction in Alkaline Media SO ACS CATALYSIS LA English DT Article DE Pd-Ni-P catalyst; ethanol electrooxidation; direct ethanol fuel cells; kinetics and mechanisms of EOR; substitutional/interstitial alloy ID OXYGEN REDUCTION REACTION; FORMIC-ACID ELECTROOXIDATION; ALCOHOL FUEL-CELLS; METHANOL ELECTROOXIDATION; ANODE CATALYSTS; NANOPARTICLES; PERFORMANCE; NANOALLOY; PALLADIUM; TEMPLATE AB A class of Pd-Ni-P electrocatalysts are prepared for the ethanol electrooxidation reaction (EOR). X-ray diffraction and transmission electron microscope reveal that the synthesized Pd-Ni-P catalyst possesses a more amorphous structure with smaller particle sizes when compared with a Pd-Ni sample without P and a control Pd black (Pd-blk) sample. The Pd-Ni-P catalyst contains double the number of electrocatalytically active sites (12.03%) compared with the Pd-Ni (6.04%) and Pd-blk (5.12%) samples. For the EOR, the Pd-Ni-P catalyst has the lowest onset potential (-0.88 V vs SCE), the most negative peak potential (-0.27 V vs SCE), and the highest EOR activity in 0.1 M KOH solution. Moreover, a 110 mV decrease in overpotential is observed for the EOR on the Pd-Ni-P catalyst compared with the Pd-blk catalyst. A Tafel slope of 60 mV/dec at low polarization potentials (<-0.76 V vs SCE) was obtained for EOR at a Pd-Ni-P-coated electrode with a reaction rate constant of 2.8 x 10(-4) cm.S-1.M-1 at -0.3 V vs SCE in KOH media. Finally, we find that the electrooxidation of ethanol on the Pd-Ni-P catalyst undergoes a 4-electron process to acetate. C1 [Jiang, Rongzhong; Tran, Dat T.; McClure, Joshua P.; Chu, Deryn] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Jiang, RZ (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM Rongzhong.jiang.civ@mail.mil FU U.S. Department of the Army; U.S. Army Materiel Command FX The authors would like to thank Dr. Panju Shang at University of Maryland for assisting TEM analysis. Thanks to Dr. Cynthia Lundgren for helpful discussions. Finally, thanks to the U.S. Department of the Army and U.S. Army Materiel Command for supporting this work. NR 45 TC 31 Z9 31 U1 10 U2 113 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2155-5435 J9 ACS CATAL JI ACS Catal. PD AUG PY 2014 VL 4 IS 8 BP 2577 EP 2586 DI 10.1021/cs500462z PG 10 WC Chemistry, Physical SC Chemistry GA AM6OF UT WOS:000339983800020 ER PT J AU Ganem, VJ Mora, A Varney, SM Bebarta, VS AF Ganem, V. J. Mora, A. Varney, S. M. Bebarta, V. S. TI An analysis of opioid prescribing practices for non-chronic pain by emergency department providers SO CLINICAL TOXICOLOGY LA English DT Meeting Abstract DE Opioid; Non-chronic Pain; Emergency Department C1 [Ganem, V. J.; Varney, S. M.; Bebarta, V. S.] San Antonio Mil Med Ctr, San Antonio, TX USA. [Mora, A.] US Army Inst Surg Res, San Antonio, TX USA. RI Bebarta, Vikhyat/M-1513-2015; bebarta, vikhyat/K-3476-2015 NR 0 TC 0 Z9 0 U1 0 U2 1 PU INFORMA HEALTHCARE PI NEW YORK PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA SN 1556-3650 EI 1556-9519 J9 CLIN TOXICOL JI Clin. Toxicol. PD AUG PY 2014 VL 52 IS 7 MA 234 BP 788 EP 788 PG 1 WC Toxicology SC Toxicology GA AN0UE UT WOS:000340298700240 ER PT J AU Smith, ML Nichols, DC Underwood, P Fuller, Z Moser, MA LoDico, C Gorelick, DA Newmeyer, MN Concheiro, M Huestis, MA AF Smith, Michael L. Nichols, Daniel C. Underwood, Paula Fuller, Zachary Moser, Matthew A. LoDico, Charles Gorelick, David A. Newmeyer, Matthew N. Concheiro, Marta Huestis, Marilyn A. TI Morphine and codeine concentrations in human urine following controlled poppy seeds administration of known opiate content SO FORENSIC SCIENCE INTERNATIONAL LA English DT Article DE Poppy seeds; Urine; Morphine; Codeine; Controlled dose ID 6-ACETYLMORPHINE; CONSUMPTION AB Opiates are an important component for drug testing due to their high abuse potential. Proper urine opiate interpretation includes ruling out poppy seed ingestion; however, detailed elimination studies after controlled poppy seed administration with known morphine and codeine doses are not available. Therefore, we investigated urine opiate pharmacokinetics after controlled oral administration of uncooked poppy seeds with known morphine and codeine content. Participants were administered two 45 g oral poppy seed doses 8 h apart, each containing 15.7 mg morphine and 3 mg codeine. Urine was collected ad libitum up to 32 h after the first dose. Specimens were analyzed with the Roche Opiates II immunoassay at 2000 and 300 mu g/L cutoffs, and the ThermoFisher CEDIA (R) heroin metabolite (6-acetylmorphine, 6-AM) and Lin-Zhi 6-AM immunoassays with 10 mu g/L cutoffs to determine if poppy seed ingestion could produce positive results in these heroin marker assays. In addition, all specimens were quantified for morphine and codeine by GC/MS. Participants (N = 22) provided 391 urine specimens over 32 h following dosing; 26.6% and 83.4% were positive for morphine at 2000 and 300 mu g/L GC/MS cutoffs, respectively. For the 19 subjects who completed the study, morphine concentrations ranged from <300 to 7522 mu g/L with a median peak concentration of 5239 mu g/L. The median first morphine-positive urine sample at 2000 mu g/L cutoff concentration occurred at 6.6 h (1.2-12.1), with the last positive from 2.6 to 18 h after the second dose. No specimens were positive for codeine at a cutoff concentration of 2000 mu g/L, but 20.2% exceeded 300 mu g/L, with peak concentrations of 658 mu g/L (284-1540). The Roche Opiates II immunoassay had efficiencies greater than 96% for the 2000 and 300 mu g/L cutoffs. The CEDIA 6-AM immunoassay had a specificity of 91%, while the Lin-Zhi assay had no false positive results. These data provide valuable information for interpreting urine opiate results. (C) 2014 Published by Elsevier Ireland Ltd. C1 [Smith, Michael L.; Nichols, Daniel C.; Underwood, Paula; Fuller, Zachary; Moser, Matthew A.] US Army, Forens Toxicol Drug Testing Lab, Ft George G Meade, MD USA. [LoDico, Charles] Dept Hlth & Human Serv, Abuse Mental Hlth Serv Adm, Div Workplace Programs, Rockville, MD USA. [Gorelick, David A.; Newmeyer, Matthew N.; Concheiro, Marta; Huestis, Marilyn A.] NIDA, Intramural Res Program, NIH, Baltimore, MD 21224 USA. [Gorelick, David A.] Univ Maryland, Sch Med, Dept Psychiat, Baltimore, MD 21201 USA. [Newmeyer, Matthew N.] Univ Maryland, Toxicol Program, Baltimore, MD 21201 USA. RP Huestis, MA (reprint author), NIDA, Intramural Res Program, NIH, 251 Bayview Blvd,Suite 200,Rm O5A-721, Baltimore, MD 21224 USA. EM mhuestis@intra.nida.nih.gov OI Concheiro, Marta/0000-0002-3858-1280; Newmeyer, Matthew/0000-0002-0653-1553 FU Intramural Research Program of the National Institutes of Health, National Institute on Drug Abuse; Division of Workplace Programs, Substance Abuse Mental Health Services Administration, USA FX This work was supported by the Intramural Research Program of the National Institutes of Health, National Institute on Drug Abuse and the Division of Workplace Programs, Substance Abuse Mental Health Services Administration, USA. The opinions in this article are those of the authors and do not necessarily reflect the views of the United States Department of Army or Department of Defense. NR 15 TC 8 Z9 8 U1 0 U2 33 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0379-0738 EI 1872-6283 J9 FORENSIC SCI INT JI Forensic Sci.Int. PD AUG PY 2014 VL 241 BP 87 EP 90 DI 10.1016/j.forsciint.2014.04.042 PG 4 WC Medicine, Legal SC Legal Medicine GA AM7KU UT WOS:000340046700018 PM 24887324 ER PT J AU Lu, Z Wang, WY Wang, C AF Lu, Zhuo Wang, Wenye Wang, Cliff TI Modeling, Evaluation and Detection of Jamming Attacks in Time-Critical Wireless Applications SO IEEE TRANSACTIONS ON MOBILE COMPUTING LA English DT Article DE Performance modeling; wireless network; time-critical messaging; jamming attack detection; smart grid applications ID SERVICE ATTACKS; NETWORKS; COMMUNICATION AB Recently, wireless networking for emerging cyber-physical systems, in particular the smart grid, has been drawing increasing attention in that it has broad applications for time-critical message delivery among electronic devices on physical infrastructures. However, the shared nature of wireless channels unavoidably exposes the messages in transit to jamming attacks, which broadcast radio interference to affect the network availability of electronic equipments. An important, yet open research question is how to model and detect jamming attacks in such wireless networks, where communication traffic is more time-critical than that in conventional data-service networks, such as cellular and WiFi networks. In this paper, we aim at modeling and detecting jamming attacks against time-critical wireless networks with applications to the smart grid. In contrast to communication networks where packets-oriented metrics, such as packet loss and throughput are used to measure the network performance, we introduce a new metric, message invalidation ratio, to quantify the performance of time-critical applications. Our modeling approach is inspired by the similarity between the behavior of a jammer who attempts to disrupt the delivery of a time-critical message and the behavior of a gambler who intends to win a gambling game. Therefore, by gambling-based modeling and real-time experiments, we find that there exists a phase transition phenomenon for successful time-critical message delivery under a variety of jamming attacks. That is, as the probability that a packet is jammed increases from 0 to 1, the message invalidation ratio first increases slightly, then increases dramatically to 1. Based on analytical and experimental results, we design the Jamming Attack Detection based on Estimation (JADE) scheme to achieve robust jamming detection, and implement JADE in a wireless network for power substations in the smart grid. C1 [Lu, Zhuo; Wang, Wenye] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. [Wang, Cliff] Army Res Off, Res Triangle Pk, NC 27709 USA. RP Lu, Z (reprint author), N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. EM zlu3@ncsu.edu; wwang@ncsu.edu; cliff.wang@us.army.mil FU Army Research Office (ARO) staff research [W911NF-07-R-0001-05]; Defense Threat Reduction Agency (DTRA) research [HDTRA1-08-1-0024] FX The work was supported by the Army Research Office (ARO) staff research grant W911NF-07-R-0001-05 and the Defense Threat Reduction Agency (DTRA) research grant HDTRA1-08-1-0024. An earlier version of the work was published in IEEE INFOCOM 2011. NR 31 TC 10 Z9 10 U1 3 U2 21 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1536-1233 EI 1558-0660 J9 IEEE T MOBILE COMPUT JI IEEE. Trans. Mob. Comput. PD AUG PY 2014 VL 13 IS 8 BP 1746 EP 1759 DI 10.1109/TMC.2013.146 PG 14 WC Computer Science, Information Systems; Telecommunications SC Computer Science; Telecommunications GA AM8EM UT WOS:000340104100008 ER PT J AU Krueger, CA Wenke, JC AF Krueger, Chad A. Wenke, Joseph C. TI Initial injury severity and social factors determine ability to deploy after combat-related amputation SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED LA English DT Article DE Amputee deployment; Amputee activity; Amputee level of function; Mangled extremity; Amputation ID LOWER-EXTREMITY TRAUMA; LOWER-LIMB AMPUTATION; PHYSICAL-ACTIVITY; AMPUTEES; PARTICIPATION; RETURN; SALVAGE; WORK; DISABILITY; METAANALYSIS AB Objective: While many recent publications have examined the ability of amputees to return to active duty, it remains largely unknown why few amputees deploy after amputation and many amputees do not. The purpose of this study is to examine what predictor(s) exist for whether or not an amputee will deploy after sustaining a combat-related amputation. Methods: All U. S. Service members who sustained major extremity amputations from September 2001 through July 2011 were analysed. Amputation level(s), mechanism of injury, time interval to amputation, age, rank, Physical Evaluation Board (PEB) disposition and ability to deploy after amputation were determined. Results: Deployment information after amputation was obtained for 953 amputees. There were 47 (5%) amputees who deployed. There were no significant differences amongst service branches for the deployment of amputees (p > 0.2). Amputees who underwent their amputation on the same day of their injury were significantly less likely to deploy after amputation than those who had their amputation on the day of injury (p = .01). Deployed amputees had significantly lower Injury Severity Scores than amputees who did not deploy (15.98 vs 20.87, p < 0.01) and officers were significantly (p < .01) more likely to deploy and the average age of amputees who deployed was significantly higher than those who did not (27.5 vs 25.1, p < .01). Lastly, those amputees who sustained a transtibial amputation were significantly more likely to deploy than all other amputation levels (p < .01). Nine out of 19 (47%) Special Forces amputees were able to deploy. Discussion: The vast majority of amputees do not able to deploy after undergoing amputation. The main predictors of deploying after sustaining a combat-related amputation appear to be: sustaining a transtibial amputation, being of senior rank or age and being a member of the Special Forces. Many of these factors appear to be non-treatment related and highlight the importance that individual and social factors play in the recovery of severe injuries. Published by Elsevier Ltd. C1 [Krueger, Chad A.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. [Wenke, Joseph C.] US Army Inst Surg Res, Ft Sam Houston, TX USA. RP Krueger, CA (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM chad.a.krueger4.mil@mail.mil; joseph.c.wenke.civ@mail.mil NR 33 TC 3 Z9 3 U1 4 U2 14 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0020-1383 EI 1879-0267 J9 INJURY JI Injury-Int. J. Care Inj. PD AUG PY 2014 VL 45 IS 8 BP 1231 EP 1235 DI 10.1016/j.injury.2014.02.008 PG 5 WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery GA AN0MU UT WOS:000340279500016 PM 24613612 ER PT J AU Rao, PM Walter, TR Sankar, B Subhash, G Yen, CF AF Rao, Prabhakar M. Walter, Timothy R. Sankar, Bhavani Subhash, Ghatu Yen, Chian F. TI Analysis of failure modes in three-dimensional woven composites subjected to quasi-static indentation SO JOURNAL OF COMPOSITE MATERIALS LA English DT Article DE 3D Woven composites; indentation mechanics; anisotropic yielding; failure modes; delamination cracking ID LOW-VELOCITY IMPACT; TEXTILE COMPOSITES; BINARY MODEL; DAMAGE; 2D; DELAMINATION; RESISTANCE; STRENGTH; BEHAVIOR; STRESS AB Finite element models are developed to predict potential failure initiation sites and associated failure modes in S2-Glass/SC15 three-dimensional (3D) woven composites under quasi-static indentation. As part of this modeling effort, experimental micrographs of the composite specimen obtained from a previous experimental study(1,2) are analyzed. In conjunction with these micrographs, model outcomes demonstrate the ability of warp weavers or through-thickness Z-yarns to shield inter-laminar cracks. Quasi-static indentation is modeled as a contact interaction between a rigid cylindrical indenter and a deformable S2-Glass/SC15 3D woven composite laminate using ABAQUS (R). Tow elements are modeled as transversely isotropic elastic-plastic material entities, whereas the inter-tow matrix is modeled as an isotropic elastic-plastic material. Through-thickness failure modes are predicted based on the Tsai-Hill criterion. Contour maps of these failure modes point to the location and corresponding damage initiation mode within the material. Experimentally obtained micrographs 1,2 are then analyzed on the basis of these contour maps, thereby serving to validate the modeling methodology. The effect of Z-yarns is demonstrated with the aid of two-dimensional plane strain linear elastic fracture mechanics analysis. Crack shielding abilities of the Z-yarns manifest as the variation of strain energy release rate as a function of crack length and location. In the vicinity of a Z-yarn, the energy release rate decreases precipitously, indicating the inability of the crack to penetrate the Z-yarns. C1 [Rao, Prabhakar M.] United Technol Res Ctr, Solid Mech Grp, Dept Phys Sci, E Hartford, CT 06108 USA. [Walter, Timothy R.; Sankar, Bhavani; Subhash, Ghatu] Univ Florida, Dept Mech & Aerosp Engn, Gainesville, FL USA. [Yen, Chian F.] US Army, Res Lab, Aberdeen Proving Ground, MD USA. RP Rao, PM (reprint author), United Technol Res Ctr, Solid Mech Grp, Dept Phys Sci, 411 Silver Lane,MS 129-73, E Hartford, CT 06108 USA. EM raomp@utrc.utc.com RI Walter, Thomas/K-4857-2015 FU United States Army Research Office [W911NF-08-1-0120]; United States Army Research Laboratory (ARL) FX The funding for this work was provided by the United States Army Research Office (Grant number W911NF-08-1-0120), with Dr Bruce LaMattina as the Program Manager and the United States Army Research Laboratory (ARL). The authors are grateful for the financial support. NR 35 TC 0 Z9 0 U1 1 U2 20 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0021-9983 EI 1530-793X J9 J COMPOS MATER JI J. Compos Mater. PD AUG PY 2014 VL 48 IS 20 BP 2473 EP 2491 DI 10.1177/0021998313499950 PG 19 WC Materials Science, Composites SC Materials Science GA AM9ND UT WOS:000340207400004 ER PT J AU Jordan, JB Naito, CJ Haque, BZ AF Jordan, Joseph B. Naito, Clay J. Haque, Bazle Z. (Gama) TI Quasi-static, low-velocity impact and ballistic impact behavior of plain weave E-glass/phenolic composites SO JOURNAL OF COMPOSITE MATERIALS LA English DT Article DE Material properties; low-velocity impact (LVI); E-glass/phenolic; ballistic limit; depth of penetration ID PENETRATION AB Quasi-static, low-velocity impact (LVI) and ballistic impact loading conditions were used to find the material properties and dynamic responses of E-glass/phenolic composites. Standard American Society for Testing and Materials (ASTM) tests were used to find the density, Poisson's ratio, tensile, compressive and shear strengths, and the elastic and shear moduli of the material. The quasi-static punch shear and crush strength tests were used to find the punch shear and crush strengths of the material. LVI tests were conducted to obtain force versus time curves for various loading conditions. Ballistic testing was conducted using a right circular cylinder (RCC) to find the V-50 ballistic limit and the depth of penetration of the RCC at various impact velocities. The experimental results of this investigation can be used for structural design and to validate numerical solutions for both LVI and ballistic impact events. C1 [Jordan, Joseph B.] US Army, Engn Res & Dev Ctr, Survivabil Engn Branch, APO, AE USA. [Naito, Clay J.] Lehigh Univ, Dept Civil Engn, Bethlehem, PA USA. [Haque, Bazle Z. (Gama)] UD CCM, Newark, DE USA. RP Jordan, JB (reprint author), US Army, Engn Res & Dev Ctr, APO, AE 09630 USA. EM joseph.b.jordan@usace.army.mil OI Naito, Clay/0000-0003-3835-8131 NR 25 TC 3 Z9 3 U1 2 U2 9 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0021-9983 EI 1530-793X J9 J COMPOS MATER JI J. Compos Mater. PD AUG PY 2014 VL 48 IS 20 BP 2505 EP 2516 DI 10.1177/0021998313499952 PG 12 WC Materials Science, Composites SC Materials Science GA AM9ND UT WOS:000340207400006 ER PT J AU Hairston, WD Whitaker, KW Ries, AJ Vettel, JM Bradford, JC Kerick, SE McDowell, K AF Hairston, W. David Whitaker, Keith W. Ries, Anthony J. Vettel, Jean M. Bradford, J. Cortney Kerick, Scott E. McDowell, Kaleb TI Usability of four commercially-oriented EEG systems SO JOURNAL OF NEURAL ENGINEERING LA English DT Article DE EEG; neuroimaging; system comparison; real-world ID WIRELESS EEG; WALKING; CLASSIFICATION; ELECTRODE; SIGNALS; MOBILE AB Electroencephalography ( EEG) holds promise as a neuroimaging technology that can be used to understand how the human brain functions in real-world, operational settings while individuals move freely in perceptually-rich environments. In recent years, several EEG systems have been developed that aim to increase the usability of the neuroimaging technology in real-world settings. Here, the usability of three wireless EEG systems from different companies are compared to a conventional wired EEG system, BioSemi's ActiveTwo, which serves as an established laboratory-grade 'gold standard' baseline. The wireless systems compared include Advanced Brain Monitoring's B-Alert X10, Emotiv Systems' EPOC and the 2009 version of QUASAR's Dry Sensor Interface 10-20. The design of each wireless system is discussed in relation to its impact on the system's usability as a potential real-world neuroimaging system. Evaluations are based on having participants complete a series of cognitive tasks while wearing each of the EEG acquisition systems. This report focuses on the system design, usability factors and participant comfort issues that arise during the experimental sessions. In particular, the EEG systems are assessed on five design elements: adaptability of the system for differing head sizes, subject comfort and preference, variance in scalp locations for the recording electrodes, stability of the electrical connection between the scalp and electrode, and timing integration between the EEG system, the stimulus presentation computer and other external events. C1 [Hairston, W. David; Whitaker, Keith W.; Ries, Anthony J.; Vettel, Jean M.; Bradford, J. Cortney; Kerick, Scott E.; McDowell, Kaleb] US Army Res Lab, Human Res & Engn Directorate, Translat Neurosci Branch, Aberdeen Proving Ground, MD 21001 USA. [Bradford, J. Cortney] Univ Michigan, Sch Kinesiol, Human Neuromech Lab, Ann Arbor, MI 48109 USA. RP Hairston, WD (reprint author), US Army Res Lab, Human Res & Engn Directorate, Translat Neurosci Branch, Aberdeen Proving Ground, MD 21001 USA. EM william.d.hairston4.civ@mail.mil OI Hairston, W. David/0000-0003-4432-8430 NR 40 TC 19 Z9 19 U1 3 U2 40 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 1741-2560 EI 1741-2552 J9 J NEURAL ENG JI J. Neural Eng. PD AUG PY 2014 VL 11 IS 4 AR 046018 DI 10.1088/1741-2560/11/4/046018 PG 14 WC Engineering, Biomedical; Neurosciences SC Engineering; Neurosciences & Neurology GA AM7KS UT WOS:000340046500018 ER PT J AU Jangraw, DC Wang, J Lance, BJ Chang, SF Sajda, P AF Jangraw, David C. Wang, Jun Lance, Brent J. Chang, Shih-Fu Sajda, Paul TI Neurally and ocularly informed graph-based models for searching 3D environments SO JOURNAL OF NEURAL ENGINEERING LA English DT Article DE brain-computer interface; EEG; eye tracking; pupillometry; computer vision ID BRAIN-COMPUTER INTERFACE; INDEPENDENT COMPONENT ANALYSIS; FIXATION-RELATED POTENTIALS; EYE-MOVEMENTS; VISUAL-SEARCH; PUPIL SIZE; EEG; TRACKING; ARTIFACT; VISION AB Objective. As we move through an environment, we are constantly making assessments, judgments and decisions about the things we encounter. Some are acted upon immediately, but many more become mental notes or fleeting impressions-our implicit 'labeling' of the world. In this paper, we use physiological correlates of this labeling to construct a hybrid brain-computer interface (hBCI) system for efficient navigation of a 3D environment. Approach. First, we record electroencephalographic (EEG), saccadic and pupillary data from subjects as they move through a small part of a 3D virtual city under free-viewing conditions. Using machine learning, we integrate the neural and ocular signals evoked by the objects they encounter to infer which ones are of subjective interest to them. These inferred labels are propagated through a large computer vision graph of objects in the city, using semi-supervised learning to identify other, unseen objects that are visually similar to the labeled ones. Finally, the system plots an efficient route to help the subjects visit the 'similar' objects it identifies. Main results. We show that by exploiting the subjects' implicit labeling to find objects of interest instead of exploring naively, the median search precision is increased from 25% to 97%, and the median subject need only travel 40% of the distance to see 84% of the objects of interest. We also find that the neural and ocular signals contribute in a complementary fashion to the classifiers' inference of subjects' implicit labeling. Significance. In summary, we show that neural and ocular signals reflecting subjective assessment of objects in a 3D environment can be used to inform a graph-based learning model of that environment, resulting in an hBCI system that improves navigation and information delivery specific to the user's interests. C1 [Jangraw, David C.; Sajda, Paul] Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA. [Wang, Jun; Chang, Shih-Fu; Sajda, Paul] Columbia Univ, Dept Elect Engn, New York, NY 10027 USA. [Lance, Brent J.] US Army, Res Lab, Translat Neurosci Branch, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21001 USA. [Chang, Shih-Fu] Columbia Univ, Dept Comp Sci, New York, NY 10027 USA. [Sajda, Paul] Columbia Univ, Dept Radiol, New York, NY 10027 USA. RP Jangraw, DC (reprint author), Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA. EM psajda@columbia.edu FU Army Research Laboratory [W911NF-10-2-0022] FX The authors would like to thank Ansh Johri and Meron Gribetz for their invaluable work refining the virtual environments and developing the route traversal scripts. Research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-10-2-0022. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory of the US Government. The US Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 54 TC 8 Z9 8 U1 3 U2 14 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 1741-2560 EI 1741-2552 J9 J NEURAL ENG JI J. Neural Eng. PD AUG PY 2014 VL 11 IS 4 AR 046003 DI 10.1088/1741-2560/11/4/046003 PG 12 WC Engineering, Biomedical; Neurosciences SC Engineering; Neurosciences & Neurology GA AM7KS UT WOS:000340046500003 PM 24891496 ER PT J AU Davis, JS Satahoo, SS Butler, FK Dermer, H Naranjo, D Julien, K Van Haren, RM Namias, N Blackbourne, LH Schulman, CI AF Davis, James S. Satahoo, Shevonne S. Butler, Frank K. Dermer, Harrison Naranjo, Daniel Julien, Katherina Van Haren, Robert M. Namias, Nicholas Blackbourne, Lorne H. Schulman, Carl I. TI An analysis of prehospital deaths: Who can we save? SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Death; wounds and injuries; emergency medical services; trauma ID OPERATION-IRAQI-FREEDOM; COMBAT CASUALTY CARE; MAJOR LIMB TRAUMA; TOURNIQUET USE; PREVENTABLE DEATH; RURAL STATE; MORTALITY; BATTLEFIELD; OUTCOMES; INJURY AB BACKGROUND: Since their inception in the late 1970s, trauma networks have saved thousands of lives in the prehospital setting. However, few recent works have been done to evaluate the patients who die in the field. Understanding the epidemiology of these deaths is crucial for trauma system performance evaluation and improvement. We hypothesized that specific patterns of injury could be identified and targeted for intervention. METHODS: Medical examiner reports in a large, urban county were reviewed including all trauma deaths during 2011 that were not transported to a hospital (i.e., died at the scene) or dead on arrival. Age, sex, date of death, mechanism, and list of injuries were recorded. An expert panel reviewed each case to determine the primary cause of death, and if the patient's death was caused by potentially survivable injuries or nonsurvivable injuries. RESULTS: A total of 512 patients were included. Patients were 80% male, died mostly of blunt (53%) and penetrating (46%) causes, and included 21% documented suicides. The leading cause of death was neurotrauma (36%), followed by hemorrhage (34%), asphyxia (15%), and combined neurotrauma/hemorrhage (15%). The anatomic regions most frequently injured were the brain (59%), chest (54%), and abdomen (35%). Finally, 29% of the patient deaths were classified as a result of potentially survivable injuries given current treatment options, mostly from hemorrhage and chest injuries. CONCLUSION: More than one of every five trauma deaths in our study population had potentially survivable injuries. In this group, chest injuries and death via hemorrhage were predominant and suggest targets for future research and implementation of novel prehospital interventions. In addition, efforts targeting suicide prevention remain of great importance. Copyright (C) 2014 by Lippincott Williams & Wilkins C1 [Davis, James S.; Satahoo, Shevonne S.; Naranjo, Daniel; Julien, Katherina; Van Haren, Robert M.; Namias, Nicholas; Schulman, Carl I.] Univ Miami, Miller Sch Med, DeWitt Daughtry Dept Surg, Jackson Mem Hosp, Miami, FL 33101 USA. [Butler, Frank K.] Joint Trauma Syst San Antonio, Comm Tact Combat Casualty Care & Prehosp Trauma C, San Antonio, TX USA. [Blackbourne, Lorne H.] Brooke Army Med Ctr, Dept Surg, San Antonio, TX USA. [Butler, Frank K.] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD 20814 USA. RP Schulman, CI (reprint author), Univ Miami, Miller Sch Med, DeWitt Daughtry Family Dept Surg, POB 016960 D-40, Miami, FL 33101 USA. EM cschulman@med.miami.edu NR 33 TC 15 Z9 15 U1 1 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2014 VL 77 IS 2 BP 213 EP 218 DI 10.1097/TA.0000000000000292 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA AN0EJ UT WOS:000340255700006 PM 25058244 ER PT J AU Dennison, SM Anasti, KM Jaeger, FH Stewart, SM Pollara, J Liu, PH Kunz, EL Zhang, RJ Vandergrift, N Permar, S Ferrari, G Tomaras, GD Bonsignori, M Michael, NL Kim, JH Kaewkungwal, J Nitayaphan, S Pitisuttithum, P Rerks-Ngarm, S Liao, HX Haynes, BF Alam, SM AF Dennison, S. Moses Anasti, Kara M. Jaeger, Frederick H. Stewart, Shelley M. Pollara, Justin Liu, Pinghuang Kunz, Erika L. Zhang, Ruijun Vandergrift, Nathan Permar, Sallie Ferrari, Guido Tomaras, Georgia D. Bonsignori, Mattia Michael, Nelson L. Kim, Jerome H. Kaewkungwal, Jaranit Nitayaphan, Sorachai Pitisuttithum, Punnee Rerks-Ngarm, Supachai Liao, Hua-Xin Haynes, Barton F. Alam, S. Munir TI Vaccine-Induced HIV-1 Envelope gp120 Constant Region 1-Specific Antibodies Expose a CD4-Inducible Epitope and Block the Interaction of HIV-1 gp140 with Galactosylceramide SO JOURNAL OF VIROLOGY LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; RECOMBINANT GLYCOPROTEIN-120 VACCINE; NEUTRALIZING HUMAN-ANTIBODY; EFFICACY TRIAL; MONOCLONAL-ANTIBODY; EPITHELIAL-CELLS; DOUBLE-BLIND; T-CELLS; QUANTITATIVE MEASUREMENTS; VIROLOGICAL SYNAPSES AB Mucosal epithelial cell surface galactosylceramide (Galcer) has been postulated to be a receptor for HIV-1 envelope (Env) interactions with mucosal epithelial cells. Disruption of the HIV-1 Env interaction with such alternate receptors could be one strategy to prevent HIV-1 entry through the mucosal barrier. To study antibody modulation of HIV-1 Env-Galcer interactions, we used Galcer-containing liposomes to assess whether natural-and vaccine-induced monoclonal antibodies can block HIV-1 Env binding to Galcer. HIV-1 Env gp140 proteins bound to Galcer liposomes with K(d)s (dissociation constants) in the nanomolar range. Several HIV-1 ALVAC/AIDSVAX vaccinee-derived monoclonal antibodies (MAbs) specific for the gp120 first constant (C1) region blocked Galcer binding of a transmitted/founder HIV-1 Env gp140. Among the C1-specific MAbs that showed Galcer blocking, the antibody-dependent cellular cytotoxicity-mediating CH38 IgG and its natural IgA isotype were the most potent blocking antibodies. C1-specific IgG monoclonal antibodies that blocked Env binding to Galcer induced upregulation of the gp120 CD4-inducible (CD4i) epitope bound by MAb 17B, demonstrating that a conformational change in gp120 may be required for Galcer blocking. However, the MAb 17B itself did not block Env-Galcer binding, suggesting that the C1 antibody-induced gp120 conformational changes resulted in alteration in a Galcer binding site distant from the CD4i 17B MAb binding site. C1 [Dennison, S. Moses; Anasti, Kara M.; Jaeger, Frederick H.; Stewart, Shelley M.; Liu, Pinghuang; Kunz, Erika L.; Zhang, Ruijun; Vandergrift, Nathan; Permar, Sallie; Ferrari, Guido; Tomaras, Georgia D.; Bonsignori, Mattia; Liao, Hua-Xin; Haynes, Barton F.; Alam, S. Munir] Duke Univ, Sch Med, Duke Human Vaccine Inst, Durham, NC 27708 USA. [Bonsignori, Mattia; Liao, Hua-Xin; Haynes, Barton F.; Alam, S. Munir] Duke Univ, Sch Med, Dept Med, Durham, NC 27706 USA. [Permar, Sallie; Tomaras, Georgia D.; Haynes, Barton F.] Duke Univ, Sch Med, Dept Immunol, Durham, NC USA. [Ferrari, Guido; Tomaras, Georgia D.] Duke Univ, Sch Med, Dept Surg, Durham, NC USA. [Alam, S. Munir] Duke Univ, Sch Med, Dept Pathol, Durham, NC 27706 USA. [Permar, Sallie] Duke Univ, Sch Med, Dept Pediat, Durham, NC USA. [Permar, Sallie; Tomaras, Georgia D.] Duke Univ, Sch Med, Dept Mol Genet & Microbiol, Durham, NC USA. [Michael, Nelson L.; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Kaewkungwal, Jaranit; Pitisuttithum, Punnee] Mahidol Univ, Bangkok 10700, Thailand. [Nitayaphan, Sorachai] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand. RP Alam, SM (reprint author), Duke Univ, Sch Med, Duke Human Vaccine Inst, Durham, NC 27708 USA. EM hayne002@mc.duke.edu; alam0004@mc.duke.edu RI Ferrari, Guido/A-6088-2015; Tomaras, Georgia/J-5041-2016 FU Bill & Melinda Gates Foundation [OPP1033098, OPP1040758]; Center for HIV/AIDS Vaccine Immunology (CHAVI) [AI067854]; Center for HIV/AIDS Vaccine Immunogen Discovery (CHAVI- ID) from the NIH, NIAID [UM1AI100645- 01] FX This research was conducted as part of the Collaboration for AIDS Vaccine Discovery (CAVD) with support from the Bill & Melinda Gates Foundation to B.F.H. (OPP1033098 and OPP1040758) and from the Center for HIV/AIDS Vaccine Immunology (CHAVI; AI067854) and the Center for HIV/AIDS Vaccine Immunogen Discovery (CHAVI- ID; UM1AI100645- 01) from the NIH, NIAID. NR 66 TC 3 Z9 3 U1 0 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X EI 1098-5514 J9 J VIROL JI J. Virol. PD AUG PY 2014 VL 88 IS 16 BP 9406 EP 9417 DI 10.1128/JVI.01031-14 PG 12 WC Virology SC Virology GA AM7HP UT WOS:000340036800056 PM 24920809 ER PT J AU Dittmar, EM Cimprich, DA Sperry, JH Weatherhead, PJ AF Dittmar, Erika M. Cimprich, David A. Sperry, Jinelle H. Weatherhead, Patrick J. TI Habitat Selection by Juvenile Black-Capped Vireos Following Independence from Parental Care SO JOURNAL OF WILDLIFE MANAGEMENT LA English DT Article DE endangered species; habitat use; juvenile movements; juvenile songbirds; post-breeding; post-fledging; radio-telemetry; riparian; Vireo atricapilla ID OVENBIRDS SEIURUS-AUROCAPILLA; TEMPERATE FORESTS; SURVIVAL; RIPARIAN; VEGETATION; MOVEMENTS; BIRDS; ROBINS; STREAM; COVER AB If differences in ecological requirements result in juvenile birds using different habitats from breeding birds, then habitat management to protect those birds must protect both breeding and post-breeding habitats. We examined habitat selection by juvenile black-capped vireos (Vireo atricapilla) following their independence from parental care, in 2010-2013 on Fort Hood Military Reservation in central Texas, USA. The black-capped vireo is a federally endangered species that nests almost exclusively in shrub vegetation, but previous anecdotal observations indicate that juveniles may prefer riparian vegetation. We used mist-net capture rates and radio-telemetry to determine relative abundance of juvenile vireos across habitats, to quantify movement patterns and habitat selection, and to investigate how vegetation density and arthropod abundance influenced habitat selection. We captured juveniles at similar rates in shrub and riparian vegetation. Radio telemetry data indicated that juveniles selected riparian vegetation over most other available vegetation types, and tended to stay in riparian vegetation upon arrival. Juveniles selected areas characterized by more canopy cover, denser foliage, and more arthropods. Riparian vegetation provides this combination of features more than other vegetation types, indicating that cover and food are the basis for habitat selection by juveniles. Our results indicate that habitat conservation strategies for black-capped vireos should include protection of riparian vegetation near breeding areas, and more generally, that avian conservation strategies that focus only on breeding areas may potentially overlook other key habitats. (c) 2014 The Wildlife Society. C1 [Dittmar, Erika M.; Sperry, Jinelle H.; Weatherhead, Patrick J.] Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA. [Cimprich, David A.] Environm Div, Ft Hood, TX 76544 USA. [Sperry, Jinelle H.] Engineer Res & Dev Ctr, Champaign, IL 61826 USA. RP Dittmar, EM (reprint author), Univ Illinois, Dept Nat Resources & Environm Sci, W-519 Turner Hall,1102 S Goodwin Ave, Urbana, IL 61801 USA. EM erikadittmar@yahoo.com FU Texas Parks and Wildlife Department, Austin, Texas; Student Conservation Association's Segal AmeriCorps Education Award FX We thank A. Harless, C. Godwin, C. Rankhorn, C. Wass, G. Palmer, J. Perez, K. Comolli, M. Chan, M. Heimbuch, M. Singh, P. Cimprich, and R. Palmer for their assistance in the field. We are also thankful for the additional support from B. DeGregorio, C. Picinich, D. Kovar, M. Noble, M. Ward, S. Summers, and T. Hayden. Financial support for this project was provided by Texas Parks and Wildlife Department, Austin, Texas. Additional financial support is provided by the Student Conservation Association's Segal AmeriCorps Education Award. This project was completed in cooperation with U.S. Army Fort Hood Natural Resources Branch, The Nature Conservancy, and University of Illinois Urbana-Champaign. The content of this manuscript does not reflect the position or policy of the United States government and no official endorsement should be inferred. NR 32 TC 2 Z9 2 U1 0 U2 45 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-541X EI 1937-2817 J9 J WILDLIFE MANAGE JI J. Wildl. Manage. PD AUG PY 2014 VL 78 IS 6 BP 1005 EP 1011 DI 10.1002/jwmg.738 PG 7 WC Ecology; Zoology SC Environmental Sciences & Ecology; Zoology GA AN0TN UT WOS:000340297000007 ER PT J AU Burgess, E AF Burgess, Edwin TI The Real Custer: From Boy General to Tragic Hero SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] US Army Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. RP Burgess, E (reprint author), US Army Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 2 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD AUG PY 2014 VL 139 IS 13 BP 108 EP 108 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA AM7DM UT WOS:000340024900236 ER PT J AU Burgess, E AF Burgess, Edwin TI Soldier Girls: The Battles of Three Women at Home and at War SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] US Army Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. RP Burgess, E (reprint author), US Army Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD AUG PY 2014 VL 139 IS 13 BP 113 EP 113 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA AM7DM UT WOS:000340024900262 ER PT J AU Herrell, RK Edens, EN Riviere, LA Thomas, JL Bliese, PD Hoge, CW AF Herrell, Richard K. Edens, Edward N. Riviere, Lyndon A. Thomas, Jeffrey L. Bliese, Paul D. Hoge, Charles W. TI Assessing Functional Impairment in a Working Military Population: The Walter Reed Functional Impairment Scale SO PSYCHOLOGICAL SERVICES LA English DT Article DE functional impairment; military; scale; validation; Land Combat Study ID POSTTRAUMATIC-STRESS-DISORDER; TRAUMATIC BRAIN-INJURY; MENTAL-HEALTH PROBLEMS; PRIMARY-CARE; SOMATIC SYMPTOMS; PHYSICAL HEALTH; WAR VETERANS; IRAQ WAR; COMBAT; ASSOCIATION AB Measurement of functional impairment is a priority for the military and other professional work groups routinely exposed to stressful traumatic events as part of their occupation. Standard measures of impairment used in general or chronically ill populations contain many items not suitable for these populations, and include mental health symptoms items that are not true measures of functioning. We created a new, 14-item scale-the Walter Reed Functional Impairment Scale-to assess functioning in 4 domains (physical, occupational, social, and personal). We asked 3,380 soldiers how much difficulty they currently have in each of the 4 domains on a 5-point scale. Behaviorally based psychosocial and occupational performance measures and general health questions were used to validate the scale. The utility of the scale was assessed against clinical measures of psychopathology and physical health (depression, posttraumatic stress disorder [PTSD], general health, generalized physical symptoms). We utilized Cronbach's alpha, item response theory, and the score test for trend to establish consistency of items and the validity of the scale. The scale exhibited excellent reliability (Cronbach's alpha = 0.92) and validity. The individual items and quartiles of sum scores were strongly correlated with negative occupational and social performance, and the utility of the scale was demonstrated by strong correlations with depression, PTSD, and high levels of generalized physical symptoms. This scale exhibits excellent psychometric properties in this sample of U. S. soldiers and, pending future research, is likely to have utility for other healthy occupational groups. C1 [Herrell, Richard K.; Riviere, Lyndon A.; Bliese, Paul D.; Hoge, Charles W.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Edens, Edward N.] US Army Training & Doctrine Command, Ft Eustis, VA USA. [Thomas, Jeffrey L.] US Army Med Res Unit Europe, Walter Reed Army Inst Res, Sembach, Germany. RP Herrell, RK (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Mil Psychiat Branch, Silver Spring, MD 20910 USA. EM richard.k.herrell.ctr@mail.mil NR 43 TC 3 Z9 3 U1 3 U2 13 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 1541-1559 EI 1939-148X J9 PSYCHOL SERV JI Psychol. Serv. PD AUG PY 2014 VL 11 IS 3 BP 254 EP 264 DI 10.1037/a0037347 PG 11 WC Psychology, Clinical SC Psychology GA AN0SS UT WOS:000340294900002 PM 25068298 ER PT J AU Russell, DW Whalen, RJ Riviere, LA Clarke-Walper, K Bliese, PD Keller, DD Pangelian, SI Thomas, JL AF Russell, Dale W. Whalen, Ronald J. Riviere, Lyndon A. Clarke-Walper, Kristina Bliese, Paul D. Keller, Darc D. Pangelian, Susan I. Thomas, Jeffrey L. TI Embedded Behavioral Health Providers: An Assessment With the Army National Guard SO PSYCHOLOGICAL SERVICES LA English DT Article DE Army; behavioral health; embedded provider; National Guard; unit climate ID MENTAL-HEALTH; ACTIVE-DUTY; COMBAT; BARRIERS; CARE; SOLDIERS; STIGMA; IRAQ; PREVALENCE; MULTILEVEL AB Although the Army has recently begun the practice of embedding behavioral health care providers (EBHP) in units in an effort to improve soldier well-being, the efficacy of this practice has not been evaluated. This study assesses 1 of the first programs implemented by the military. Using cross-sectional data obtained from a confidential survey of 12 company-level units in the California Army National Guard (n = 1,132), this study examines differences between units with and without EBHPs across a number of measures. Multilevel analysis of behavioral health symptoms, unit climate, perceptions of stigma, and practical barriers to care failed to detect main effects between units with EBHPs relative to those without. However, cross-level interactions were detected between unit EBHP status and soldiers reporting close relationship (e.g., spouse, girlfriend/boyfriend) impairment. Exploratory findings suggest that, among soldiers reporting close relationship impairment, those belonging to units with EBHPs reported significantly lower behavioral health symptoms and significantly more positive unit climates. Based on these limited exploratory finings, this study suggests that EBHPs in reserve units may have a positive effect on a subset of soldiers (i.e., those reporting close relationship impairment). More assessments of embed programs should be conducted, particularly using prospective longitudinal data among randomized units. C1 [Russell, Dale W.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Psychiat, Bethesda, MD 20814 USA. [Russell, Dale W.; Whalen, Ronald J.; Riviere, Lyndon A.; Clarke-Walper, Kristina; Bliese, Paul D.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Keller, Darc D.; Pangelian, Susan I.] Calif Natl Guard, Sacramento, CA USA. [Thomas, Jeffrey L.] US Army Med Res Unit Europe, Heidelberg, Germany. RP Russell, DW (reprint author), Walter Reed Army Inst Res, 530 Robert Grant Ave, Silver Spring, MD 20910 USA. EM dale.w.russell1.mil@mail.mil NR 37 TC 3 Z9 3 U1 0 U2 2 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 1541-1559 EI 1939-148X J9 PSYCHOL SERV JI Psychol. Serv. PD AUG PY 2014 VL 11 IS 3 BP 265 EP 272 DI 10.1037/a0037005 PG 8 WC Psychology, Clinical SC Psychology GA AN0SS UT WOS:000340294900003 PM 24841511 ER PT J AU Kalish, VB Gillham, JE Unwin, BK AF Kalish, Virginia B. Gillham, Joseph E. Unwin, Brian K. TI Delirium in Older Persons: Evaluation and Management SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; TERMINALLY-ILL PATIENTS; PREVENTING DELIRIUM; ELDERLY-PATIENTS; RISK-FACTORS; HALOPERIDOL PROPHYLAXIS; DECREASES DELIRIUM; FUNCTIONAL DECLINE; NONCARDIAC SURGERY; MORTALITY AB Delirium is defined as an acute, fluctuating syndrome of altered attention, awareness, and cognition. It is common in older persons in the hospital and long-term care facilities and may indicate a life-threatening condition. Assessment for and prevention of delirium should occur at admission and continue throughout a hospital stay. Caregivers should be educated on preventive measures, as well as signs and symptoms of delirium and conditions that would indicate the need for immediate evaluation. Certain medications, sensory impairments, cognitive impairment, and various medical conditions are a few of the risk factors associated with delirium. Preventive interventions such as frequent reorientation, early and recurrent mobilization, pain management, adequate nutrition and hydration, reducing sensory impairments, and ensuring proper sleep patterns have all been shown to reduce the incidence of delirium, regardless of the care environment. Treatment of delirium should focus on identifying and managing the causative medical conditions, providing supportive care, preventing complications, and reinforcing preventive interventions. Pharmacologic interventions should be reserved for patients who are a threat to their own safety or the safety of others and those patients nearing death. In older persons, delirium increases the risk of functional decline, institutionalization, and death. Copyright (C) 2014 American Academy of Family Physicians C1 [Kalish, Virginia B.] Natl Capitol Consortium, Ft Belvoir, VA 22060 USA. [Gillham, Joseph E.] Robinson Hlth Clin, Ft Bragg, NC USA. [Unwin, Brian K.] Caril Clin, Roanoke, VA USA. RP Kalish, VB (reprint author), Natl Capitol Consortium, 9300 Dewitt Loop, Ft Belvoir, VA 22060 USA. EM virginia.b.kalish.civ@health.mil NR 49 TC 7 Z9 8 U1 1 U2 18 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X EI 1532-0650 J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD AUG 1 PY 2014 VL 90 IS 3 BP 150 EP 158 PG 9 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA AM6PU UT WOS:000339987900003 PM 25077720 ER PT J AU Kuchuloria, T Imnadze, P Chokheli, M Tsertsvadze, T Endeladze, M Mshvidobadze, K Clark, DV Bautista, CT Fadeel, MA Pimentel, G House, B Hepburn, MJ Wolfel, S Wolfel, R Rivard, RG AF Kuchuloria, Tinatin Imnadze, Paata Chokheli, Maiko Tsertsvadze, Tengiz Endeladze, Marina Mshvidobadze, Ketevan Clark, Danielle V. Bautista, Christian T. Fadeel, Moustafa Abdel Pimentel, Guillermo House, Brent Hepburn, Matthew J. Woelfel, Silke Woelfel, Roman Rivard, Robert G. TI Short Report: Viral Hemorrhagic Fever Cases in the Country of Georgia: Acute Febrile Illness Surveillance Study Results SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID HANTAVIRUS AB Minimal information is available on the incidence of Crimean-Congo hemorrhagic fever (CCHF) virus and hantavirus infections in Georgia. From 2008 to 2011, 537 patients with fever >= 38 degrees C for >= 48 hours without a diagnosis were enrolled into a sentinel surveillance study to investigate the incidence of nine pathogens, including CCHF virus and hantavirus. Of 14 patients with a hemorrhagic fever syndrome, 3 patients tested positive for CCHF virus immunoglobulin M (IgM) antibodies. Two of the patients enrolled in the study had acute renal failure. These 2 of 537 enrolled patients were the only patients in the study positive for hantavirus IgM antibodies. These results suggest that CCHF virus and hantavirus are contributing causes of acute febrile syndromes of infectious origin in Georgia. These findings support introduction of critical diagnostic approaches and confirm the need for additional surveillance in Georgia. C1 [Kuchuloria, Tinatin; Imnadze, Paata; Tsertsvadze, Tengiz] I Javakhishvili Tbilisi State Univ, GE-0179 Tbilisi, Rep of Georgia. [Imnadze, Paata; Chokheli, Maiko] Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia. [Tsertsvadze, Tengiz; Endeladze, Marina; Mshvidobadze, Ketevan] Infect Dis AIDS & Clin Immunol Res Ctr, Tbilisi, Rep of Georgia. [Clark, Danielle V.; Bautista, Christian T.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Fadeel, Moustafa Abdel; Pimentel, Guillermo; House, Brent] US Naval Med Res Unit 3, Global Dis Detect & Response Program, Cairo, Egypt. US Army Med Command, San Antonio, TX USA. [Woelfel, Silke; Woelfel, Roman] Bundeswehr Inst Microbiol, Munich, Germany. US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. RP Kuchuloria, T (reprint author), I Javakhishvili Tbilisi State Univ, 1 Chavchavadze Ave, GE-0179 Tbilisi, Rep of Georgia. EM drkuchuloria@yahoo.com; pimnadze@ncdc.ge; chokhelimaiko@yahoo.com; aids@gol.ge; marinaendeladze@ymail.com; katemshvidobadze@yahoo.com; dvclark@gmail.com; Christian.Bautista@us.army.mil; Moustafa.AbdelFadeel.eg@med.navy.mil; gpiment@gmail.com; Brent.House@med.navy.mil; matthew.hepburn@yahoo.com; silkewoelfel@bundeswehr.org; romanwoelfel@bundeswehr.org; robert.g.rivard.mil@mail.mil FU US Department of Defense Global Emerging Infections Surveillance (GEIS) Program; Medical Biodefense Research Program of the Bundeswehr Joint Medical Service; US Department of Defense Threat Reduction Agency FX This work was funded by the US Department of Defense Global Emerging Infections Surveillance (GEIS) Program and the Medical Biodefense Research Program of the Bundeswehr Joint Medical Service, and it was supported by the US Department of Defense Threat Reduction Agency. NR 12 TC 5 Z9 5 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD AUG PY 2014 VL 91 IS 2 BP 246 EP 248 DI 10.4269/ajtmh.13-0460 PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA AM4ZD UT WOS:000339863800009 PM 24891463 ER PT J AU Harte, CB Proctor, SP Vasterling, JJ AF Harte, Christopher B. Proctor, Susan P. Vasterling, Jennifer J. TI Prospective Examination of Cigarette Smoking Among Iraq-Deployed and Nondeployed Soldiers: Prevalence and Predictive Characteristics SO ANNALS OF BEHAVIORAL MEDICINE LA English DT Article DE Cigarette smoking; Predictors; Military; Operation Iraqi Freedom; Deployment; Longitudinal ID UK ARMED-FORCES; TOBACCO USE; POSTTRAUMATIC-STRESS; NICOTINE DEPENDENCE; PROSPECTIVE COHORT; MILITARY DEPLOYMENT; COMBAT EXPOSURES; UNITED-STATES; WAR VETERANS; RISK-FACTORS AB Identifying characteristics that influence smoking behavior among military personnel is critical to protect health and operational functioning. This study prospectively examined rates of cigarette smoking and predictors of changes in smoking behavior as a function of Iraq deployment. One thousand eighty-two US Army soldiers (n = 773 Iraq-deployed; n = 309 nondeployed) completed assessments at two sessions [time 1: April 2003-July 2004; time 2: May 2004-July 2004 (nondeployers); January 2005-September 2006 (deployers)]. Approximately 48 % of participants smoked at both time points, with 6 % initiating smoking and 6 % quitting. Smoking initiation was associated with warzone stress exposure; female gender and high military unit support predicted cessation. Military rank and alcohol use were associated with both smoking initiation and cessation. Findings highlight the potential benefits of targeting risk factors for cigarette smoking in comprehensive military health programs aimed at smoking prevention and cessation. C1 [Harte, Christopher B.; Proctor, Susan P.] VA Boston Healthcare Syst, Psychol Serv, Boston, MA 02130 USA. [Harte, Christopher B.; Vasterling, Jennifer J.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA. [Proctor, Susan P.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA USA. [Vasterling, Jennifer J.] VA Boston Healthcare Syst, Psychol Serv, Boston, MA 02130 USA. [Vasterling, Jennifer J.] VA Boston Healthcare Syst, VA Natl Ctr PTSD, Boston, MA 02130 USA. RP Vasterling, JJ (reprint author), VA Boston Healthcare Syst, Psychol Serv, 150 S Huntington Ave 116B, Boston, MA 02130 USA. EM jennifer.vasterling@va.gov OI Harte, Christopher/0000-0002-8097-7369 NR 61 TC 3 Z9 3 U1 1 U2 10 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0883-6612 EI 1532-4796 J9 ANN BEHAV MED JI Ann. Behav. Med. PD AUG PY 2014 VL 48 IS 1 BP 38 EP 49 DI 10.1007/s12160-013-9584-5 PG 12 WC Psychology, Multidisciplinary SC Psychology GA AM3DE UT WOS:000339731400007 PM 24474618 ER PT J AU Valenzuela, A Munson, C Porwitzky, A Weidman, M Richardson, M AF Valenzuela, Anthony Munson, Chase Porwitzky, Andrew Weidman, Matthew Richardson, Martin TI Comparison between geometrically focused pulses versus filaments in femtosecond laser ablation of steel and titanium alloys SO APPLIED PHYSICS B-LASERS AND OPTICS LA English DT Article ID INDUCED BREAKDOWN SPECTROSCOPY; MULTIPLE FILAMENTATION; TRANSPARENT MEDIA; AIR; LIBS; PROPAGATION; LIGHT; POWER; TI AB Kerr self-focusing of high-power ultrashort laser pulses in atmosphere may result in a structure or structures of high intensity that can propagate over long distances with little divergence. Filamentation has garnered significant interest in the nonlinear optics community due to its unique properties. Salient features of filaments include a central region of intense laser power (greater than the ionization threshold of the propagation medium) and a low temperature plasma column that lasts up to nanoseconds in duration after the passage of the laser pulse. Steel and titanium samples are ablated by filaments and by sharply focused sub-picosecond laser pulses. We then performed metrology on the samples to compare the ablation features in addition to modeling of the plasma ablation process. Ablation with filaments leads to a wider range of material responses as compared to ablation with sharply focused pulse. This results in potential complications for applications of filament ablation that depends on the rate of material removal and spectroscopic analysis. C1 [Valenzuela, Anthony; Munson, Chase; Porwitzky, Andrew] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Weidman, Matthew; Richardson, Martin] Univ Cent Florida, Coll Opt & Photon, Townes Laser Inst, Orlando, FL 32816 USA. [Weidman, Matthew; Richardson, Martin] Univ Cent Florida, Coll Opt & Photon, CREOL, Orlando, FL 32816 USA. RP Valenzuela, A (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM anthony.r.valenzuela6.civ@mail.mil FU U.S. Army Research Laboratory; University of Central Florida under the JTO/AFOSR MRI [FA95501110001]; State of Florida FX The authors express their gratitude for the assistance at the U.S. Army Research Laboratory from Jeffrey Ball; Robert Borys, Jr.; Frank De Lucia, Jr.; Jennifer Gottfried; Gregory Gentle; and David MacKenzie. The authors also express their gratitude to Casey Boutwell, Ming Wei, and Matthieu Baudelet at the University of Central Florida. The authors also would like to acknowledge funding from the U.S. Army Research Laboratory and research at the University of Central Florida is funded under the JTO/AFOSR MRI on "Fundamentals of Filament Interaction" number FA95501110001 and The State of Florida. NR 32 TC 4 Z9 4 U1 2 U2 34 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0946-2171 EI 1432-0649 J9 APPL PHYS B-LASERS O JI Appl. Phys. B-Lasers Opt. PD AUG PY 2014 VL 116 IS 2 BP 485 EP 491 DI 10.1007/s00340-013-5724-7 PG 7 WC Optics; Physics, Applied SC Optics; Physics GA AM3BR UT WOS:000339727000027 ER PT J AU Williams, SG Collen, J Wickwire, E Lettieri, CJ Mysliwiec, V AF Williams, Scott G. Collen, Jacob Wickwire, Emerson Lettieri, Christopher J. Mysliwiec, Vincent TI The Impact of Sleep on Soldier Performance SO CURRENT PSYCHIATRY REPORTS LA English DT Article DE Sleep deprivation; Combat related sleep disorder; Insomnia; Obstructive sleep apnea; Sleep disordered breathing; Posttraumatic stress disorder; Nightmares ID POSTTRAUMATIC-STRESS-DISORDER; RANDOMIZED CONTROLLED-TRIAL; TRAUMATIC BRAIN-INJURY; RESTLESS LEGS SYNDROME; COGNITIVE-BEHAVIORAL THERAPY; QUALITY-OF-LIFE; STATES-MILITARY-ACADEMY; SHIFT WORK DISORDER; GENERAL-POPULATION; UNITED-STATES AB The military population is particularly vulnerable to a multitude of sleep-related disorders owing to the type of work performed by active duty servicemembers (ADSMs). Inadequate sleep, due to insufficient quantity or quality, is increasingly recognized as a public health concern. Traditionally, ADSMs have been encouraged that they can adapt to insufficient sleep just as the body adapts to physical training, but there is a substantial body of scientific literature which argues that this is not possible. Additionally, the military work environment creates unique challenges with respect to treatment options for common sleep disorders like obstructive sleep apnea, restless legs syndrome, and parasomnias. This review highlights sleep disorders which are prevalent in the modern military force and discusses the impact of poor sleep on overall performance. Medical treatments and recommendations for unit leaders are also discussed. C1 [Williams, Scott G.] Womack Army Med Ctr, Ft Bragg, NC USA. [Williams, Scott G.; Collen, Jacob; Lettieri, Christopher J.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. [Collen, Jacob] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. [Wickwire, Emerson] Howard Cty Ctr Lung & Sleep Med, Columbia, MD USA. [Wickwire, Emerson] Johns Hopkins Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD USA. [Lettieri, Christopher J.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. [Mysliwiec, Vincent] Madigan Army Med Ctr, Joint Base Lewis McChord, Tacoma, WA 98431 USA. RP Williams, SG (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med, Room A3060, Bethesda, MD 20814 USA. EM scott.g.williams@us.army.mil NR 117 TC 1 Z9 1 U1 1 U2 9 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1523-3812 EI 1535-1645 J9 CURR PSYCHIAT REP JI Curr. Psychiatry Rep. PD AUG PY 2014 VL 16 IS 8 AR 459 DI 10.1007/s11920-014-0459-7 PG 13 WC Psychiatry SC Psychiatry GA AM4CX UT WOS:000339801200003 PM 24942599 ER PT J AU Mernild, SH Liston, GE Hiemstra, CA AF Mernild, Sebastian H. Liston, Glen E. Hiemstra, Christopher A. TI Northern Hemisphere Glacier and Ice Cap Surface Mass Balance and Contribution to Sea Level Rise SO JOURNAL OF CLIMATE LA English DT Article ID SYNOPTICALLY FORCED HYDROCLIMATOLOGY; GENERAL-CIRCULATION MODELS; COMPLEX SNOW DISTRIBUTIONS; MAJOR ARCTIC WATERSHEDS; AMMASSALIK ISLAND; MITTIVAKKAT GLACIER; SOUTHEAST GREENLAND; AIR-TEMPERATURE; PRECIPITATION; CLIMATE AB Mass changes and mass contribution to sea level rise from glaciers and ice caps (GIC) are key components of the earth's changing sea level. GIC surface mass balance (SMB) magnitudes and individual and regional mean conditions and trends (1979-2009) were simulated for all GIC having areas greater or equal to 0.5 km(2) in the Northern Hemisphere north of 25 degrees N latitude (excluding the Greenland Ice Sheet). Recent datasets, including the Randolph Glacier Inventory (RGI; v. 2.0), the NOAA Global Land One-km Base Elevation Project (GLOBE), and the NASA Modern-Era Retrospective Analysis for Research and Applications (MERRA) products, together with recent SnowModel developments, allowed relatively high-resolution (1-km horizontal grid; 3-h time step) simulations of GIC surface air temperature, precipitation, sublimation, evaporation, surface runoff, and SMB. Simulated SMB outputs were calibrated against 1422 direct glaciological annual SMB observations of 78 GIC. The overall GIC mean annual and mean summer air temperature, runoff, and SMB loss increased during the simulation period. The cumulative GIC SMB was negative for all regions. The SMB contribution to sea level rise was largest from Alaska and smallest from the Caucasus. On average, the contribution to sea level rise was 0.51 +/- 0.16 mm sea level equivalent (SLE) yr(-1) for 1979-2009 and similar to 40% higher 0.71 +/- 0.15 mm SLE yr(-1) for the last decade, 1999-2009. C1 [Mernild, Sebastian H.] Los Alamos Natl Lab, Climate Ocean & Sea Ice Modeling Grp, Los Alamos, NM USA. [Mernild, Sebastian H.] Ctr Sci Studies, Glaciol & Climate Change Lab, Valdivia 5110466, Chile. [Liston, Glen E.] Colorado State Univ, Cooperat Inst Res Atmosphere, Ft Collins, CO 80523 USA. [Hiemstra, Christopher A.] US Army Cold Reg Res & Engn Lab, Ft Wainwright, AK USA. RP Mernild, SH (reprint author), Ctr Sci Studies, Glaciol & Climate Change Lab, Valdivia 5110466, Chile. EM smernild@gmail.com FU Earth System Modeling program within the U.S. Department of Energy's Office of Science; Scientific Discovery for Advanced Computing (SciDAC) program within the U.S. Department of Energy's Office of Science; National Nuclear Security Administration of the U.S. Department of Energy [DE-AC52-06NA25396]; European Community [262693] FX This work was supported in part by the Earth System Modeling program and by the Scientific Discovery for Advanced Computing (SciDAC) program within the U.S. Department of Energy's Office of Science, and by a Los Alamos National Laboratory (LANL) (LANL is operated under the auspices of the National Nuclear Security Administration of the U.S. Department of Energy under Contract DE-AC52-06NA25396). Additional support was provided from the European Community's Seventh Framework Programme under Grant Agreement 262693. We thank the NASA Goddard Earth Sciences (GES) Data and Information Services Center (DISC) and Global Modeling and Assimilation Office (GMAO) for providing the MERRA datasets, and NOAA for providing the Global Land One-km Base Elevation Project (GLOBE) digital elevation model. Request of data should be addressed to the first author. NR 82 TC 7 Z9 7 U1 2 U2 37 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0894-8755 EI 1520-0442 J9 J CLIMATE JI J. Clim. PD AUG 1 PY 2014 VL 27 IS 15 BP 6051 EP 6073 DI 10.1175/JCLI-D-13-00669.1 PG 23 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA AM2SY UT WOS:000339702300022 ER PT J AU Lin, YH Hanson, JA Strandjord, SE Salem, NM Dretsch, MN Haub, MD Hibbeln, JR AF Lin, Yu Hong Hanson, Jennifer A. Strandjord, Sarah E. Salem, Nicholas M. Dretsch, Michael N. Haub, Mark D. Hibbeln, Joseph R. TI Fast Transmethylation of Total Lipids in Dried Blood by Microwave Irradiation and its Application to a Population Study SO LIPIDS LA English DT Article DE Finger pricked blood; Filter paper; Dried blood spot; Microwave reaction system; PUFA; Omega-3; Omega-6 ID POLYUNSATURATED FATTY-ACIDS; GAS-CHROMATOGRAPHY; MASS-SPECTROMETRY; FINGERTIP; SUPPLEMENTATION; DROP; OMEGA-3-FATTY-ACIDS; TRANSESTERIFICATION; PEROXIDATION; VALIDATION AB A methodology combining finger-pricked blood sampling, microwave accelerated fatty acid assay, fast gas chromatography data acquisition, and automated data processing was developed, evaluated and applied to a population study. Finger-pricked blood was collected on filter paper previously impregnated with 0.05 mg of the antioxidant butylated hydroxytoluene and air-dried at room temperature. Transmethylation was accelerated by microwave irradiation in an explosion-proof multimode microwave reaction system. The chemical procedure was based on a one-step direct transmethylation procedure catalyzed by acetyl chloride. The short-term stability of PUFA in blood dried on filter paper and storage at room temperature was examined using venous blood. The recoveries ranged from 97 to 101 % for the categorized fatty acids as well as the ratios of n-6 to n-3 PUFA and the n-3 % highly unsaturated fatty acid. Specifically, recoveries were 99, 98, 97, and 97 % for linoleic acid (18:2n-6), arachidonic acid (ARA), alpha-linolenic acid (ALA), and docosahexaenoic acid (DHA), respectively. The mol% (mean +/- A SD, 95 % confidence interval) of fatty acid composition in subjects from the population study was determined as 36.2 +/- A 3.8 (35.8, 36.7), 23.2 +/- A 3.0 (22.8, 23.5), 36.8 +/- A 3.5 (36.4, 37.2) and 3.79 +/- A 1.0 (3.68, 3.91) for the saturated, monounsaturated, n-6 and n-3 PUFA, respectively. Individually, the mean mol% (95 % CI) was 22.6 (22.3, 22.9) for 18:2n-6, 9.5 (9.3, 9.7) for ARA, 0.51 (0.49, 0.53) for ALA, 0.42 (0.38, 0.47) for eicosapentaenoic acid (EPA), and 1.67 (1.61, 1.73) for DHA. This methodology provides an accelerated yet high-efficiency, chemically safe, and temperature-controlled transmethylation, with diverse laboratory applications including population studies. C1 [Lin, Yu Hong; Strandjord, Sarah E.; Salem, Nicholas M.; Hibbeln, Joseph R.] NIAAA, Lab Membrane Biochem & Biophys, NIH, Bethesda, MD 20892 USA. [Hanson, Jennifer A.] Louisiana Tech Univ, Sch Human Ecol, Ruston, LA 71270 USA. [Hanson, Jennifer A.] Kansas State Univ, Dept Hospitality Management & Dietet, Manhattan, KS 66506 USA. [Dretsch, Michael N.] Walter Reed Natl Mil Med Ctr, Natl Intrepid Ctr Excellence, Bethesda, MD USA. [Dretsch, Michael N.] US Army Aeromed Res Lab, Ft Rucker, AL USA. [Haub, Mark D.] Kansas State Univ, Dept Human Nutr, Manhattan, KS 66506 USA. RP Lin, YH (reprint author), NIAAA, Lab Membrane Biochem & Biophys, NIH, Bethesda, MD 20892 USA. EM yulin@mail.nih.gov OI Hanson, Jennifer /0000-0003-0437-6489 FU National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health FX The authors wish to acknowledge the service members who took part in the study as well as Dr. Norman Salem Jr. and Dr. Charlie N. Serhan for the valuable advice and discussion on the method development. The authors thank Mr. Brian Brown, NIH Library Writing Center, for manuscript editing assistance. This project was partially funded by the Intramural Research Program of the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health. NR 42 TC 7 Z9 7 U1 2 U2 8 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0024-4201 EI 1558-9307 J9 LIPIDS JI Lipids PD AUG PY 2014 VL 49 IS 8 BP 839 EP 851 DI 10.1007/s11745-014-3918-3 PG 13 WC Biochemistry & Molecular Biology; Nutrition & Dietetics SC Biochemistry & Molecular Biology; Nutrition & Dietetics GA AM4NP UT WOS:000339831800010 PM 24986160 ER PT J AU Zhang, L Hu, XZ Benedek, DM Fullerton, CS Forsten, RD Naifeh, JA Li, X Li, H Benevides, KN Smerin, S Le, T Choi, K Ursano, RJ AF Zhang, L. Hu, X-Z Benedek, D. M. Fullerton, C. S. Forsten, R. D. Naifeh, J. A. Li, X. Li, H. Benevides, K. N. Smerin, S. Le, T. Choi, K. Ursano, R. J. TI The interaction between stressful life events and leukocyte telomere length is associated with PTSD SO MOLECULAR PSYCHIATRY LA English DT Letter ID CARDIOVASCULAR-DISEASE; CHECKLIST C1 [Zhang, L.; Hu, X-Z; Benedek, D. M.; Fullerton, C. S.; Naifeh, J. A.; Li, X.; Li, H.; Benevides, K. N.; Smerin, S.; Le, T.; Choi, K.; Ursano, R. J.] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Ctr Study Traumat Stress, Bethesda, MD 20814 USA. [Forsten, R. D.] US Army Special Operat Command, Ft Bragg, NC USA. RP Zhang, L (reprint author), Uniformed Serv Univ Hlth Sci, Dept Psychiat, Ctr Study Traumat Stress, Bethesda, MD 20814 USA. EM Lezhang@USUHS.mil NR 10 TC 18 Z9 18 U1 0 U2 6 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1359-4184 EI 1476-5578 J9 MOL PSYCHIATR JI Mol. Psychiatr. PD AUG PY 2014 VL 19 IS 8 BP 855 EP 856 DI 10.1038/mp.2013.141 PG 3 WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry GA AM7IR UT WOS:000340040200003 PM 24189343 ER PT J AU Hoge, CW Grossman, SH Auchterlonie, JL Riviere, LA Milliken, CS Wilk, JE AF Hoge, Charles W. Grossman, Sasha H. Auchterlonie, Jennifer L. Riviere, Lyndon A. Milliken, Charles S. Wilk, Joshua E. TI PTSD Treatment for Soldiers After Combat Deployment: Low Utilization of Mental Health Care and Reasons for Dropout SO PSYCHIATRIC SERVICES LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; NATIONAL-GUARD SOLDIERS; ADMINISTRATIVE DATA; UNITED-STATES; VETERANS; IRAQ; BARRIERS; AFGHANISTAN; PREVALENCE; STIGMA AB Objective: Limited data exist on the adequacy of treatment for post-traumatic stress disorder (PTSD) after combat deployment. This study assessed the percentage of soldiers in need of PTSD treatment, the percentage receiving minimally adequate care, and reasons for dropping out of care. Methods: Data came from two sources: a population-based cohort of 45,462 soldiers who completed the Post-Deployment Health Assessment and a cross-sectional survey of 2,420 infantry soldiers after returning from Afghanistan (75% response rate). Results: Of 4,674 cohort soldiers referred to mental health care at a military treatment facility, 75% followed up with this referral. However, of 2,230 soldiers who received a PTSD diagnosis within 90 days of return from Afghanistan, 22% had only one mental health care visit and 41% received minimally adequate care (eight or more encounters in 12 months). Of 229 surveyed soldiers who screened positive for PTSD (PTSD Checklist score 50), 48% reported receiving mental health treatment in the prior six months at any health care facility. Of those receiving treatment, the median number of visits in six months was four; 22% had only one visit, 52% received minimally adequate care (four or more visits in six months), and 24% dropped out of care. Reported reasons for dropout included soldiers feeling they could handle problems on their own, work interference, insufficient time with the mental health professional, stigma, treatment ineffectiveness, confidentiality concerns, or discomfort with how the professional interacted. Conclusions: Treatment reach for PTSD after deployment remains low to moderate, with a high percentage of soldiers not accessing care or not receiving adequate treatment. This study represents a call to action to validate interventions to improve treatment engagement and retention. C1 [Hoge, Charles W.; Grossman, Sasha H.; Auchterlonie, Jennifer L.; Riviere, Lyndon A.; Milliken, Charles S.; Wilk, Joshua E.] Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Hoge, CW (reprint author), Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD 20910 USA. EM charles.hoge@us.army.mil FU U.S. Army Military Operational Research Program FX Funding was received from the U.S. Army Military Operational Research Program. The authors thank the Land Combat Study team. The views contained here are those of the authors and are not considered to be an official position of the U.S. Department of the Army or the Department of Defense. NR 37 TC 43 Z9 43 U1 3 U2 24 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 1075-2730 EI 1557-9700 J9 PSYCHIAT SERV JI Psychiatr. Serv. PD AUG PY 2014 VL 65 IS 8 BP 997 EP 1004 DI 10.1176/appi.ps.201300307 PG 8 WC Health Policy & Services; Public, Environmental & Occupational Health; Psychiatry SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Psychiatry GA AM3TU UT WOS:000339776500007 PM 24788253 ER PT J AU Quidley, AM Bland, CM Bookstaver, PB Kuper, K AF Quidley, April Miller Bland, Christopher M. Bookstaver, P. Brandon Kuper, Kristi TI Perioperative management of bariatric surgery patients SO AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY LA English DT Review ID HELICOBACTER-PYLORI INFECTION; GASTRIC BYPASS-SURGERY; SURGICAL-SITE INFECTION; MORBIDLY OBESE-PATIENTS; MOLECULAR-WEIGHT HEPARIN; QUALITY-OF-LIFE; VENOUS THROMBOEMBOLISM; POSTOPERATIVE NAUSEA; ERADICATION THERAPY; SLEEVE GASTRECTOMY AB Purpose. The perioperative management of bariatric surgery patients is described. Summary. Obesity and anatomical changes create unique challenges for clinicians when caring for bariatric surgery patients. Common bariatric surgery procedures performed include Roux-en-Y gastric bypass, sleeve gastrectomy, and adjustable gastric banding. Pain management in the acute postoperative period depends on careful dosing of opioid agents and the use of adjunctive agents. Prevention and management of infectious complications include appropriate surgical prophylaxis, monitoring and rapid treatment of suspected intra-abdominal infections, and detection and treatment of Helicobacter pylori infection. Venous thromboembolism (VTE) prophylaxis and treatment are complicated by obesity, and the use of pharmacologic agents must be balanced with bleeding risk. Bleeding is a serious complication that should be closely monitored in the immediate postoperative period. Blood products remain first-line therapy for the treatment of bleeding in this population. Acute differences in drug absorption as well as emerging hormonal changes necessitate the immediate postoperative adjustment of chronic medications to ensure both safety and efficacy. Pharmacists are valuable members of interprofessional teams for bariatric surgery patients because they provide expertise on the availability of dosage forms and dosage modification to ensure that patient pharmacotherapy is not interrupted; assist in the management of hypertension, diabetes, and psychotropic medications; and ensure appropriate antimicrobial prophylaxis and VTE prophylaxis and treatment dosages. Conclusion. The management of patients in the perioperative period of bariatric surgery requires appropriate selection and dosing of medications for pain management and treatment of infectious complications, VTE, bleeding, and other chronic diseases. C1 [Quidley, April Miller] Vidant Med Ctr, Postgrad Year Crit Care Residency Program 2, Greenville, NC 27834 USA. [Quidley, April Miller] Vidant Med Ctr, Greenville, NC USA. [Bland, Christopher M.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA. [Bland, Christopher M.] Univ S Carolina, South Carolina Coll Pharm, Columbia, SC 29208 USA. [Bookstaver, P. Brandon] Univ S Carolina, South Carolina Coll Pharm, Dept Clin Pharm & Outcomes Sci, Columbia, SC 29208 USA. [Kuper, Kristi] VHA Performance Serv, Charlotte, NC USA. RP Quidley, AM (reprint author), Vidant Med Ctr, Postgrad Year Crit Care Residency Program 2, Greenville, NC 27834 USA. EM aprilmillerrx@gmail.com NR 94 TC 3 Z9 5 U1 0 U2 9 PU AMER SOC HEALTH-SYSTEM PHARMACISTS PI BETHESDA PA 7272 WISCONSIN AVE, BETHESDA, MD 20814 USA SN 1079-2082 EI 1535-2900 J9 AM J HEALTH-SYST PH JI Am. J. Health-Syst. Pharm. PD AUG 1 PY 2014 VL 71 IS 15 BP 1253 EP 1264 DI 10.2146/ajhp130679 PG 12 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA AM1ZI UT WOS:000339647400009 PM 25027532 ER PT J AU Fowler, J Mahlen, SD AF Fowler, John Mahlen, Steven D. TI Localized Cutaneous Infections in Immunocompetent Individuals Due to Rapidly Growing Mycobacteria SO ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE LA English DT Article ID NONTUBERCULOUS MYCOBACTERIA; CHELONAE INFECTION; SKIN; SUSCEPTIBILITY; OUTBREAK; TATTOO AB Rapidly growing mycobacteria (RGM) cause skin infections that are refractory to standard antibiotic regimens. Although typically associated with disseminated cutaneous or other systemic infections in immunocompromised patients, RGM sometimes cause localized cutaneous infections in immunocompetent hosts. These infections are almost always associated with precedent skin trauma and inoculation, and therefore have been implicated in outbreaks involving contaminated tattoo ink and inadequately sterilized acupuncture needles. Histologic features often include suppurative granulomatous inflammation, and microorganisms are rarely visualized with stains for acid-fast bacilli. The differential diagnosis includes granulomatous fungal and non-RGM bacterial infections as well as noninfectious suppurative or sarcoidlike conditions. Because no pathognomonic histologic features exist for cutaneous RGM infections, clinical suspicion and appropriate workup are essential to reach an accurate and timely diagnosis. Most localized cutaneous RGM infections in immunocompetent individuals respond well to either clarithromycin or amikacin, in combination with surgical debridement. C1 [Fowler, John] Madigan Army Med Ctr, Pathol & Area Lab Serv, Tacoma, WA 98431 USA. [Mahlen, Steven D.] Walter Reed Army Inst Res, Bacterial Dis Branch, Silver Spring, MD 20910 USA. RP Mahlen, SD (reprint author), Walter Reed Army Inst Res, Bacterial Dis Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM steven.mahlen@us.army.mil NR 30 TC 3 Z9 3 U1 0 U2 2 PU COLL AMER PATHOLOGISTS PI NORTHFIELD PA C/O KIMBERLY GACKI, 325 WAUKEGAN RD, NORTHFIELD, IL 60093-2750 USA SN 0003-9985 EI 1543-2165 J9 ARCH PATHOL LAB MED JI Arch. Pathol. Lab. Med. PD AUG PY 2014 VL 138 IS 8 BP 1106 EP 1109 DI 10.5858/arpa.2012-0203-RS PG 4 WC Medical Laboratory Technology; Medicine, Research & Experimental; Pathology SC Medical Laboratory Technology; Research & Experimental Medicine; Pathology GA AM1PN UT WOS:000339619900020 PM 25076301 ER PT J AU Scharine, AA Binseel, MS Mermagen, T Letowski, TR AF Scharine, Angelique A. Binseel, Mary S. Mermagen, Timothy Letowski, Tomasz R. TI Sound localisation ability of soldiers wearing infantry ACH and PASGT helmets SO ERGONOMICS LA English DT Article DE auditory situation awareness; sound localisation; helmets; monaural localisation cues; spatial orientation ID HUMAN LISTENERS AB Helmets provide soldiers with ballistic and fragmentation protection but impair auditory spatial processing. Missed auditory information can be fatal for a soldier; therefore, helmet design requires compromise between protection and optimal acoustics. Twelve soldiers localised two sound signals presented from six azimuth angles and three levels of elevation presented at two intensity levels and with three background noises. Each participant completed the task while wearing no helmet and with two U.S. Army infantry helmets - the Personnel Armor System for Ground Troops (PASGT) helmet and the Advanced Combat Helmet (ACH). Results showed a significant effect of helmet type on the size of both azimuth and elevation error. The effects of level, background noise, azimuth and elevation were found to be significant. There was no effect of sound signal type. As hypothesised, localisation accuracy was greatest when soldiers did not wear helmet, followed by the ACH. Performance was worst with the PASGT helmet. Practitioner Summary: A soldier's headgear provides ballistic protection but decreases his ability to accurately localise sound sources. Soldiers performed a sound localisation task with no helmet and while wearing each of two Army helmets. The study confirmed that the ACH had less impact on auditory spatial perception than the PASGT helmet. C1 [Scharine, Angelique A.; Binseel, Mary S.; Mermagen, Timothy; Letowski, Tomasz R.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Scharine, AA (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM angelique.a.scharine.civ@mail.mil NR 16 TC 0 Z9 0 U1 2 U2 12 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0014-0139 EI 1366-5847 J9 ERGONOMICS JI Ergonomics PD AUG PY 2014 VL 57 IS 8 BP 1222 EP 1243 DI 10.1080/00140139.2014.917202 PG 22 WC Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Engineering; Psychology GA AL8QU UT WOS:000339404800009 PM 24840132 ER PT J AU Yankowitz, M Wang, JIJ Birdwell, AG Chen, YA Watanabe, K Taniguchi, T Jacquod, P San-Jose, P Jarillo-Herrero, P LeRoy, BJ AF Yankowitz, Matthew Wang, Joel I-Jan Birdwell, A. Glen Chen, Yu-An Watanabe, K. Taniguchi, T. Jacquod, Philippe San-Jose, Pablo Jarillo-Herrero, Pablo LeRoy, Brian J. TI Electric field control of soliton motion and stacking in trilayer graphene SO NATURE MATERIALS LA English DT Article ID BILAYER GRAPHENE; BORON-NITRIDE; ABA AB The crystal structure of a material plays an important role in determining its electronic properties. Changing from one crystal structure to another involves a phase transition that is usually controlled by a state variable such as temperature or pressure. In the case of trilayer graphene, there are two common stacking configurations (Bernal and rhombohedral) that exhibit very different electronic properties(1-11). In graphene flakes with both stacking configurations, the region between them consists of a localized strain soliton where the carbon atoms of one graphene layer shift by the carbon-carbon bond distance(12-18). Here we show the ability to move this strain soliton with a perpendicular electric field and hence control the stacking configuration of trilayer graphene with only an external voltage. Moreover, we find that the free-energy difference between the two stacking configurations scales quadratically with electric field, and thus rhombohedral stacking is favoured as the electric field increases. This ability to control the stacking order in graphene opens the way to new devices that combine structural and electrical properties. C1 [Yankowitz, Matthew; Jacquod, Philippe; LeRoy, Brian J.] Univ Arizona, Dept Phys, Tucson, AZ 85721 USA. [Wang, Joel I-Jan; Chen, Yu-An; Jarillo-Herrero, Pablo] MIT, Dept Phys, Cambridge, MA 02138 USA. [Wang, Joel I-Jan] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA. [Birdwell, A. Glen] US Army, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Watanabe, K.; Taniguchi, T.] Natl Inst Mat Sci, Tsukuba, Ibaraki 3050044, Japan. [San-Jose, Pablo] CSIC, Inst Ciencia Mat Madrid, E-28049 Madrid, Spain. RP LeRoy, BJ (reprint author), Univ Arizona, Dept Phys, Tucson, AZ 85721 USA. EM leroy@physics.arizona.edu RI San-Jose, Pablo/A-4795-2010; TANIGUCHI, Takashi/H-2718-2011; WATANABE, Kenji/H-2825-2011; Jacquod, Philippe/J-6385-2016 OI San-Jose, Pablo/0000-0002-7920-5273; WATANABE, Kenji/0000-0003-3701-8119; Jacquod, Philippe/0000-0002-0587-3535 FU US Army Research Laboratory; US Army Research Office [W911NF-09-1-0333]; Taiwan Merit Scholarship [TMS-094-1-A-001]; US DOE, BES Office, Division of Materials Sciences and Engineering [DE-SC0001819]; NSF [DMR-0845287, DMR-0819762, ECS-0335765]; ONR GATE MURI; Harvard's CNS; US Army Research Laboratory (ARL) Director's Strategic Initiative; Spanish Ministry of Economy (MINECO) [FIS2011-23713]; European Research Council Advanced Grant [290846]; European Commission [CNECT-ICT-604391] FX RS-J. acknowledges fruitful discussions with J. F. Rossier. M.Y. and B.J.L. were supported by the US Army Research Laboratory and the US Army Research Office under contract/grant number W911NF-09-1-0333. J.I-J.W. was partially supported by a Taiwan Merit Scholarship TMS-094-1-A-001. J.I-J.W and P.J-H. have been primarily supported by the US DOE, BES Office, Division of Materials Sciences and Engineering under Award DE-SC0001819. Early fabrication feasibility studies were supported by NSF Career Award No. DMR-0845287 and the ONR GATE MURI. This work made use of the MRSEC Shared Experimental Facilities supported by NSF under award No. DMR-0819762 and of Harvard's CNS, supported by NSF under grant No. ECS-0335765. A.G.B. was supported by the US Army Research Laboratory (ARL) Director's Strategic Initiative program on interfaces in stacked 2D atomic layered materials. P.S-J. received financial support from the Spanish Ministry of Economy (MINECO) through Grant no. FIS2011-23713, the European Research Council Advanced Grant (contract 290846) and from the European Commission under the Graphene Flagship (contract CNECT-ICT-604391). NR 24 TC 23 Z9 23 U1 2 U2 75 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1476-1122 EI 1476-4660 J9 NAT MATER JI Nat. Mater. PD AUG PY 2014 VL 13 IS 8 BP 786 EP 789 DI 10.1038/NMAT3965 PG 4 WC Chemistry, Physical; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Materials Science; Physics GA AM1ZM UT WOS:000339647800017 PM 24776537 ER PT J AU Taylor, ODS McKenna, MH Quinn, MCL Quinn, BG AF Taylor, Oliver-Denzil S. McKenna, Mihan H. Quinn, Meghan C. L. Quinn, Brian G. TI Partially saturated soil causing significant variability in near surface seismic signals SO NEAR SURFACE GEOPHYSICS LA English DT Article ID PROPAGATION; STIFFNESS; EXPLOSIONS; ARRAYS; SANDS; RATIO AB The behaviour of dry, moist, and saturated soils has been studied for over a century without adequately investigating the behaviour associated with transient saturation in the near surface, i.e. the upper 1 m of overburden, including the effects of rapid meteorological changes, dynamic fluid flow, and variability of saturation on shallow seismic sensors. This paper presents observational data wherein the geophysical instrumentation response was significantly influenced by near-surface post-precipitation saturation and additional laboratory experimentation on the effects of saturation on shear wave velocity. The lack of partially-saturated data is primarily because transient meteorological events have not been critically important to the types of long-term deployments performed in the past, where sensors were situated in hard-rock, collecting data under idealized conditions, as opposed to sedimentary settings. Shorter-duration deployments and smaller system architectures, e. g. persistent monitoring, now necessitate detailed a priori knowledge of meteorological impacts to system design and performance. The purpose of this persistent monitoring geophysical instrumentation is to continually monitor the near surface and relate small perturbations to a specific source type(s) and distance(s) from the receiver. As such, the received signal is compared to known sources within a predetermined geological/meteorological condition. Presented herein is the calibration signal generated by a 3.63-kg (8-lb) sledgehammer prior to and post 36 hours of steady precipitation. The resulting subsurface seismic velocity time-histories show a significant increase in signal amplitude, change in frequency content and no change in duration. Thus, the amplification effects of near-surface moisture variability combined with dynamic pore fluid could be interpreted as false positives of a specific source signature and/or instrument failure. C1 [Taylor, Oliver-Denzil S.; McKenna, Mihan H.; Quinn, Meghan C. L.; Quinn, Brian G.] US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, CEERD GS S, Vicksburg, MS 39180 USA. RP Taylor, ODS (reprint author), US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, CEERD GS S, Bldg 5014,3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Oliver.D.Taylor@usace.army.mil NR 63 TC 1 Z9 1 U1 0 U2 5 PU EUROPEAN ASSOC GEOSCIENTISTS & ENGINEERS PI 3990 DB, HOUTEN PA PO BOX 59, 3990 DB, HOUTEN, 00000, NETHERLANDS SN 1569-4445 EI 1873-0604 J9 NEAR SURF GEOPHYS JI Near Surf. Geophys. PD AUG PY 2014 VL 12 IS 4 BP 467 EP 480 DI 10.3997/1873-0604.2013039 PG 14 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA AM1RA UT WOS:000339624500002 ER PT J AU Holloway, JL Lowman, AM VanLandingham, MR Palmese, GR AF Holloway, Julianne L. Lowman, Anthony M. VanLandingham, Mark R. Palmese, Giuseppe R. TI Interfacial optimization of fiber-reinforced hydrogel composites for soft fibrous tissue applications SO ACTA BIOMATERIALIA LA English DT Article DE Poly(vinyl alcohol); Hydrogel; Composite; Interfacial strength; Meniscus ID NUCLEUS PULPOSUS REPLACEMENT; MECHANICAL-PROPERTIES; ARTICULAR-CARTILAGE; PLASMA TREATMENT; ADHESION; POLYMER; MENISCUS; BEHAVIOR; MODULUS AB Meniscal tears are the most common orthopedic injuries to the human body, yet the current treatment of choice is a partial meniscectomy, which is known to lead to joint degeneration and osteoarthritis. As a result, there is a significant clinical need to develop materials capable of restoring function to the meniscus following an injury. Fiber-reinforced hydrogel composites are particularly suited for replicating the mechanical function of native fibrous tissues due to their ability to mimic the native anisotropic property distribution present. A critical issue with these materials, however, is the potential for the fiber-matrix interfacial properties to severely limit composite performance. In this work, the interfacial properties of an ultra-high-molecular-weight polyethylene (UHMWPE) fiber-reinforced poly(vinyl alcohol) (PVA) hydrogel are studied. A novel chemical grafting technique, confirmed using X-ray photoelectron spectroscopy, is used to improve UHMWPE-PVA interfacial adhesion. Interfacial shear strength is quantified using fiber pull-out tests. Results indicate significantly improved fiber-hydrogel interfacial adhesion after chemical grafting, where chemically grafted samples have an interfacial shear strength of 256.4 +/- 64.3 kPa compared to 11.5 +/- 2.9 kPa for untreated samples. Additionally, scanning electron microscopy of fiber surfaces after fiber pull-out reveal cohesive failure within the hydrogel matrix for treated fiber samples, indicating that the UHMWPE-PVA interface has been successfully optimized. Lastly, inter-fiber spacing is observed to have a significant effect on interfacial adhesion. Fibers spaced further apart have significantly higher interfacial shear strengths, which is critical to consider when optimizing composite design. The results in this study are applicable in developing similar chemical grafting techniques and optimizing fiber-matrix interfacial properties for other hydrogel-based composite systems. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Holloway, Julianne L.; Lowman, Anthony M.; Palmese, Giuseppe R.] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. [VanLandingham, Mark R.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Palmese, GR (reprint author), Drexel Univ, Dept Chem & Biol Engn, 3141 Chestnut St, Philadelphia, PA 19104 USA. EM grp27@drexel.edu FU National Defense Science and Engineering Graduate (NDSEG) Fellowship; U.S. Army Research Laboratory through Army Materials Center of Excellence Program [W911NF-06-2-0013]; NSF MRI-R2 Grant [CBET-0959361] FX Funding was provided through the National Defense Science and Engineering Graduate (NDSEG) Fellowship, in addition to funding by the U.S. Army Research Laboratory through the Army Materials Center of Excellence Program, Contract W911NF-06-2-0013. The authors also wish to acknowledge Drexel University Core Research Facilities for use of the XPS and SEM. In particular, the XPS instrumentation facility was made possible by the NSF MRI-R2 Grant (CBET-0959361). NR 29 TC 7 Z9 7 U1 5 U2 39 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1742-7061 EI 1878-7568 J9 ACTA BIOMATER JI Acta Biomater. PD AUG PY 2014 VL 10 IS 8 BP 3581 EP 3589 DI 10.1016/j.actbio.2014.05.004 PG 9 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA AL9KH UT WOS:000339459500021 PM 24814880 ER PT J AU Leung, LY Larimore, Z Holmes, L Cartagena, C Mountney, A Deng-Bryant, Y Schmid, K Shear, D Tortella, F AF Leung, Lai Yee Larimore, Zachary Holmes, Larry Cartagena, Casandra Mountney, Andrea Deng-Bryant, Ying Schmid, Kara Shear, Deborah Tortella, Frank TI The WRAIR Projectile Concussive Impact Model of Mild Traumatic Brain Injury: Re-design, Testing and Preclinical Validation SO ANNALS OF BIOMEDICAL ENGINEERING LA English DT Article DE Concussion; Mild TBI; Projectile; Helmet; Impact energy; Head kinematics; Gait ID AMYLOID PRECURSOR PROTEIN; DIFFUSE AXONAL INJURY; SOMATOSENSORY CORTEX; ANIMAL-MODELS; HEAD-INJURY; RAT; LOCOMOTION; BETA; MICE; GAIT AB The WRAIR projectile concussive impact (PCI) model was developed for preclinical study of concussion. It represents a truly non-invasive closed-head injury caused by a blunt impact. The original design, however, has several drawbacks that limit the manipulation of injury parameters. The present study describes engineering advancements made to the PCI injury model including helmet material testing, projectile impact energy/head kinematics and impact location. Material testing indicated that among the tested materials, 'fiber-glass/carbon' had the lowest elastic modulus and yield stress for providing an relative high percentage of load transfer from the projectile impact, resulting in significant hippocampal astrocyte activation. Impact energy testing of small projectiles, ranging in shape and size, showed the steel sphere produced the highest impact energy and the most consistent impact characteristics. Additional tests confirmed the steel sphere produced linear and rotational motions on the rat's head while remaining within a range that meets the criteria for mTBI. Finally, impact location testing results showed that PCI targeted at the temporoparietal surface of the rat head produced the most prominent gait abnormalities. Using the parameters defined above, pilot studies were conducted to provide initial validation of the PCI model demonstrating quantifiable and significant increases in righting reflex recovery time, axonal damage and astrocyte activation following single and multiple concussions. C1 [Leung, Lai Yee; Cartagena, Casandra; Mountney, Andrea; Deng-Bryant, Ying; Schmid, Kara; Shear, Deborah; Tortella, Frank] WRAIR, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat Branch, Silver Spring, MD 20910 USA. [Larimore, Zachary; Holmes, Larry] United States Army Res Labs, Composites & Hybrid Mat Branch, Aberdeen, MD USA. RP Leung, LY (reprint author), WRAIR, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM laiyee.leung@us.army.mil FU Combat Casualty Care Research Program; Congressionally Directed Medical Research Program [W81XWH-12-2-0134] FX The views of the authors do not purport or reflect the position of the Department of the Army or the Department of Defense (para 4-3, AR 360-5). The authors declare that there are no conflicts of interest in this study. This research is funded by Combat Casualty Care Research Program and Congressionally Directed Medical Research Program (Contract #: W81XWH-12-2-0134). The authors would like to thank Weihong Yang, Francis Bustos, Megan Winter, David Miles and SGT Shawn McLoughlin for technical supports. NR 30 TC 3 Z9 3 U1 1 U2 12 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0090-6964 EI 1573-9686 J9 ANN BIOMED ENG JI Ann. Biomed. Eng. PD AUG PY 2014 VL 42 IS 8 BP 1618 EP 1630 DI 10.1007/s10439-014-1014-8 PG 13 WC Engineering, Biomedical SC Engineering GA AL8OP UT WOS:000339399000004 PM 24756867 ER PT J AU Nanayakkara, NPD Tekwani, BL Herath, HMTB Sahu, R Gettayacamin, M Tungtaeng, A van Gessel, Y Baresel, P Wickham, KS Bartlett, MS Fronczek, FR Melendez, V Ohrt, C Reichard, GA McChesney, JD Rochford, R Walker, LA AF Nanayakkara, N. P. Dhammika Tekwani, Babu L. Herath, H. M. T. Bandara Sahu, Rajnish Gettayacamin, Montip Tungtaeng, Anchalee van Gessel, Yvonne Baresel, Paul Wickham, Kristina S. Bartlett, Marilyn S. Fronczek, Frank R. Melendez, Victor Ohrt, Colin Reichard, Gregory A. McChesney, James D. Rochford, Rosemary Walker, Larry A. TI Scalable Preparation and Differential Pharmacologic and Toxicologic Profiles of Primaquine Enantiomers SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID ANTIMALARIAL-DRUG PRIMAQUINE; PNEUMOCYSTIS-CARINII; HUMAN-ERYTHROCYTES; METABOLITES; METHEMOGLOBIN; ANALOGS; ACID; PHARMACOKINETICS; GLUTATHIONE; TOXICITIES AB Hematotoxicity in individuals genetically deficient in glucose-6-phosphate dehydrogenase (G6PD) activity is the major limitation of primaquine (PQ), the only antimalarial drug in clinical use for treatment of relapsing Plasmodium vivax malaria. PQ is currently clinically used in its racemic form. A scalable procedure was developed to resolve racemic PQ, thus providing pure enantiomers for the first time for detailed preclinical evaluation and potentially for clinical use. These enantiomers were compared for antiparasitic activity using several mouse models and also for general and hematological toxicities in mice and dogs. (+)-(S)-PQ showed better suppressive and causal prophylactic activity than (-)-(R)-PQ in mice infected with Plasmodium berghei. Similarly, (+)-(S)-PQ was a more potent suppressive agent than (-)-(R)-PQ in a mouse model of Pneumocystis carinii pneumonia. However, at higher doses, (+)-(S)-PQ also showed more systemic toxicity for mice. In beagle dogs, (+)-(S)-PQ caused more methemoglobinemia and was toxic at 5 mg/kg of body weight/day given orally for 3 days, while (-)-(R)-PQ was well tolerated. In a novel mouse model of hemolytic anemia associated with human G6PD deficiency, it was also demonstrated that (-)-(R)-PQ was less hemolytic than (+)-(S)-PQ for the G6PD-deficient human red cells engrafted in the NOD-SCID mice. All these data suggest that while (+)-(S)-PQ shows greater potency in terms of antiparasitic efficacy in rodents, it is also more hematotoxic than (-)-(R)-PQ in mice and dogs. Activity and toxicity differences of PQ enantiomers in different species can be attributed to their different pharmacokinetic and metabolic profiles. Taken together, these studies suggest that (-)-(R)-PQ may have a better safety margin than the racemate in human. C1 [Nanayakkara, N. P. Dhammika; Tekwani, Babu L.; Herath, H. M. T. Bandara; Sahu, Rajnish; Walker, Larry A.] Univ Mississippi, Natl Ctr Nat Prod Res, Res Inst Pharmaceut Sci, University, MS 38677 USA. [Tekwani, Babu L.; Walker, Larry A.] Univ Mississippi, Dept Pharmacol, University, MS 38677 USA. [Gettayacamin, Montip; Tungtaeng, Anchalee; van Gessel, Yvonne] AFRIMS, US Army Med Component, Dept Vet Med, Bangkok, Thailand. [Baresel, Paul; Wickham, Kristina S.; Rochford, Rosemary] SUNY Upstate Med Univ, Dept Microbiol & Immunol, Syracuse, NY 13210 USA. [Bartlett, Marilyn S.] Indiana Univ, Sch Med, Dept Pathol & Lab Med, Indianapolis, IN USA. [Fronczek, Frank R.] Louisiana State Univ, Dept Chem, Baton Rouge, LA 70803 USA. [Melendez, Victor; Ohrt, Colin; Reichard, Gregory A.] Walter Reed Army Inst Res, Dept Expt Therapeut, Silver Spring, MD USA. [McChesney, James D.] Ironstone Separat Inc, Etta, MS USA. RP Nanayakkara, NPD (reprint author), Univ Mississippi, Natl Ctr Nat Prod Res, Res Inst Pharmaceut Sci, University, MS 38677 USA. EM dhammika@olemiss.edu FU Bill & Melinda Gates Foundation [OPP53288]; Army Medical Research & Materiel Command [W81XWH-07-2-0095, W81XWH-10-2-0059]; USDA-ARS [58-6408-2-0009] FX This study received financial support from the Bill & Melinda Gates Foundation (Phase I Grand Challenges Explorations Award no. OPP53288) and Army Medical Research & Materiel Command (grants no. W81XWH-07-2-0095 and W81XWH-10-2-0059). The NCNPR is also supported by USDA-ARS scientific cooperative agreement no. 58-6408-2-0009. NR 40 TC 6 Z9 6 U1 1 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD AUG PY 2014 VL 58 IS 8 BP 4737 EP 4744 DI 10.1128/AAC.02674-13 PG 8 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA AL6RA UT WOS:000339259200058 PM 24913163 ER PT J AU Chen, NH LaCrue, AN Teuscher, F Waters, NC Gatton, ML Kyle, DE Cheng, Q AF Chen, Nanhua LaCrue, Alexis N. Teuscher, Franka Waters, Norman C. Gatton, Michelle L. Kyle, Dennis E. Cheng, Qin TI Fatty Acid Synthesis and Pyruvate Metabolism Pathways Remain Active in Dihydroartemisinin-Induced Dormant Ring Stages of Plasmodium falciparum SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID TOXOPLASMA-GONDII; ANTIBIOTIC TOLERANCE; MALARIA PARASITES; ARTEMISININ; APICOPLAST; CULTURE; GROWTH; PERSISTENCE; INHIBITION; RESISTANCE AB Artemisinin (ART)-based combination therapy (ACT) is used as the first-line treatment of uncomplicated falciparum malaria worldwide. However, despite high potency and rapid action, there is a high rate of recrudescence associated with ART monotherapy or ACT long before the recent emergence of ART resistance. ART-induced ring-stage dormancy and recovery have been implicated as possible causes of recrudescence; however, little is known about the characteristics of dormant parasites, including whether dormant parasites are metabolically active. We investigated the transcription of 12 genes encoding key enzymes in various metabolic pathways in P. falciparum during dihydroartemisinin (DHA)-induced dormancy and recovery. Transcription analysis showed an immediate downregulation for 10 genes following exposure to DHA but continued transcription of 2 genes encoding apicoplast and mitochondrial proteins. Transcription of several additional genes encoding apicoplast and mitochondrial proteins, particularly of genes encoding enzymes in pyruvate metabolism and fatty acid synthesis pathways, was also maintained. Additions of inhibitors for biotin acetyl-coenzyme A (CoA) carboxylase and enoyl-acyl carrier reductase of the fatty acid synthesis pathways delayed the recovery of dormant parasites by 6 and 4 days, respectively, following DHA treatment. Our results demonstrate that most metabolic pathways are downregulated in DHA-induced dormant parasites. In contrast, fatty acid and pyruvate metabolic pathways remain active. These findings highlight new targets to interrupt recovery of parasites from ART-induced dormancy and to reduce the rate of recrudescence following ART treatment. C1 [Chen, Nanhua; Teuscher, Franka; Cheng, Qin] Australian Army Malaria Inst, Brisbane, Qld, Australia. [LaCrue, Alexis N.; Kyle, Dennis E.] Univ S Florida, Dept Global Hlth, Tampa, FL USA. [Teuscher, Franka; Gatton, Michelle L.; Cheng, Qin] Queensland Inst Med Res, Brisbane, Qld, Australia. [Waters, Norman C.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Gatton, Michelle L.] Queensland Univ Technol, Sch Publ Hlth & Social Work, Brisbane, Qld 4001, Australia. RP Cheng, Q (reprint author), Australian Army Malaria Inst, Brisbane, Qld, Australia. EM qin.cheng@defence.gov.au OI Gatton, Michelle/0000-0003-1188-609X FU NIH [RO1AI058973]; NHMRC [APP1021273] FX This work was partially funded by a NIH grant (RO1AI058973) and a NHMRC grant (APP1021273). NR 43 TC 15 Z9 15 U1 0 U2 8 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD AUG PY 2014 VL 58 IS 8 BP 4773 EP 4781 DI 10.1128/AAC.02647-14 PG 9 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA AL6RA UT WOS:000339259200063 PM 24913167 ER PT J AU Dyall, J Coleman, CM Hart, BJ Venkataraman, T Holbrook, MR Kindrachuk, J Johnson, RF Olinger, GG Jahrling, PB Laidlaw, M Johansen, LM Lear-Rooney, CM Glass, PJ Hensley, LE Frieman, MB AF Dyall, Julie Coleman, Christopher M. Hart, Brit J. Venkataraman, Thiagarajan Holbrook, Michael R. Kindrachuk, Jason Johnson, Reed F. Olinger, Gene G., Jr. Jahrling, Peter B. Laidlaw, Monique Johansen, Lisa M. Lear-Rooney, Calli M. Glass, Pamela J. Hensley, Lisa E. Frieman, Matthew B. TI Repurposing of Clinically Developed Drugs for Treatment of Middle East Respiratory Syndrome Coronavirus Infection SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID CHRONIC MYELOID-LEUKEMIA; MERS-COV; SAUDI-ARABIA; BALB/C MICE; VIRUS; REPLICATION; CELLS; ENTRY; CHLORPROMAZINE; INHIBITORS AB Outbreaks of emerging infections present health professionals with the unique challenge of trying to select appropriate pharmacologic treatments in the clinic with little time available for drug testing and development. Typically, clinicians are left with general supportive care and often untested convalescent-phase plasma as available treatment options. Repurposing of approved pharmaceutical drugs for new indications presents an attractive alternative to clinicians, researchers, public health agencies, drug developers, and funding agencies. Given the development times and manufacturing requirements for new products, repurposing of existing drugs is likely the only solution for outbreaks due to emerging viruses. In the studies described here, a library of 290 compounds was screened for antiviral activity against Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV). Selection of compounds for inclusion in the library was dependent on current or previous FDA approval or advanced clinical development. Some drugs that had a well-defined cellular pathway as target were included. In total, 27 compounds with activity against both MERS-CoV and SARS-CoV were identified. The compounds belong to 13 different classes of pharmaceuticals, including inhibitors of estrogen receptors used for cancer treatment and inhibitors of dopamine receptor used as antipsychotics. The drugs identified in these screens provide new targets for in vivo studies as well as incorporation into ongoing clinical studies. C1 [Dyall, Julie; Hart, Brit J.; Holbrook, Michael R.; Kindrachuk, Jason; Olinger, Gene G., Jr.; Jahrling, Peter B.; Hensley, Lisa E.] NIAID, Integrated Res Facil, NIH, Frederick, MD 21702 USA. [Coleman, Christopher M.; Venkataraman, Thiagarajan; Frieman, Matthew B.] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA. [Johnson, Reed F.; Jahrling, Peter B.] NIAID, Emerging Viral Pathogens Sect, NIH, Frederick, MD USA. [Laidlaw, Monique; Johansen, Lisa M.] Zalicus Inc, Cambridge, MA USA. [Lear-Rooney, Calli M.; Glass, Pamela J.] US Army Med Res Inst Infect Dis, Frederick, MD USA. RP Frieman, MB (reprint author), NIAID, Integrated Res Facil, NIH, Frederick, MD 21702 USA. EM MFrieman@som.umaryland.edu RI Hart, Brit/G-6205-2015 OI Kindrachuk, Jason/0000-0002-3305-7084; Venkataraman, Thiagarajan/0000-0003-0921-6345; Hart, Brit/0000-0002-9389-2786 FU Division of Intramural Research of the National Institute of Allergy and Infectious Diseases (NIAID); Integrated Research Facility (NIAID, Division of Clinical Research); Battelle Memorial Institute's prime contract with NIAID [HHSN2722007000161]; NIH [R01AI1095569]; U.S. Army Research Institute of Infectious Diseases (USAMRIID) [W81XWH-12-2-0064] FX This work was supported by the Division of Intramural Research of the National Institute of Allergy and Infectious Diseases (NIAID), the Integrated Research Facility (NIAID, Division of Clinical Research), the Battelle Memorial Institute's prime contract with NIAID (contract number HHSN2722007000161) and NIH grant R01AI1095569 (to M. B. F.), and a subcontract (W81XWH-12-2-0064) awarded to L.M.J. from the U.S. Army Research Institute of Infectious Diseases (USAMRIID). NR 46 TC 46 Z9 50 U1 1 U2 16 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD AUG PY 2014 VL 58 IS 8 BP 4885 EP 4893 DI 10.1128/AAC.03036-14 PG 9 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA AL6RA UT WOS:000339259200074 PM 24841273 ER PT J AU Nguyen, ST Williams, JD Butler, MM Ding, X Mills, DM Tashjian, TF Panchal, RG Weir, SK Moon, C Kim, HO Marsden, JA Peet, NP Bowlin, TL AF Nguyen, Son T. Williams, John D. Butler, Michelle M. Ding, Xiaoyuan Mills, Debra M. Tashjian, Tommy F. Panchal, Rekha G. Weir, Susan K. Moon, Chaeho Kim, Hwa-Ok Marsden, Jeremiah A. Peet, Norton P. Bowlin, Terry L. TI Synthesis and antibacterial evaluation of new, unsymmetrical triaryl bisamidine compounds SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS LA English DT Article ID ANTIBIOTICS; INDOLES; DESIGN; POTENT AB Herein we describe the synthesis and antibacterial evaluation of a new, unsymmetrical triaryl bisamidine compound series, [Am]-[indole]-[linker]-[HetAr/Ar]-[Am], in which [Am] is an amidine or amino group, [linker] is a benzene, thiophene or pyridine ring, and [HetAr/Ar] is a benzimidazole, imidazopyridine, benzofuran, benzothiophene, pyrimidine or benzene ring. When the [HetAr/Ar] unit is a 5,6-bicyclic heterocycle, it is oriented such that the 5-membered ring portion is connected to the [linker] unit and the 6-membered ring portion is connected to the [Am] unit. Among the 34 compounds in this series, compounds with benzofuran as the [HetAr/Ar] unit showed the highest potencies. Introduction of a fluorine atom or a methyl group to the triaryl core led to the more potent analogs. Bisamidines are more active toward bacteria while the monoamidines are more active toward mammalian cells (as indicated by low CC50 values). Importantly, we identified compound P12a (MBX 1887) with a relatively narrow spectrum against bacteria and a very high CC50 value. Compound P12a has been scaled up and is currently undergoing further evaluations for therapeutic applications. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Nguyen, Son T.; Williams, John D.; Butler, Michelle M.; Ding, Xiaoyuan; Mills, Debra M.; Tashjian, Tommy F.; Peet, Norton P.; Bowlin, Terry L.] Microbiotix Inc, Worcester, MA 01604 USA. [Panchal, Rekha G.] US Army Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Weir, Susan K.] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA. [Moon, Chaeho; Kim, Hwa-Ok] CreaGen Biosci Inc, Woburn, MA 01801 USA. [Marsden, Jeremiah A.] Organ Consultants Inc, Eugene, OR 97401 USA. RP Nguyen, ST (reprint author), Microbiotix Inc, 1 Innovat Dr, Worcester, MA 01604 USA. EM snguyen@microbiotix.com FU National Institute of Allergy and Infectious Disease of the National Institutes of Health [U01AI082052, R43AI83032] FX Research reported in this article was generously supported by the National Institute of Allergy and Infectious Disease of the National Institutes of Health under award numbers U01AI082052 and R43AI83032. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. NR 22 TC 6 Z9 6 U1 1 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0960-894X EI 1464-3405 J9 BIOORG MED CHEM LETT JI Bioorg. Med. Chem. Lett. PD AUG 1 PY 2014 VL 24 IS 15 BP 3366 EP 3372 DI 10.1016/j.bmcl.2014.05.094 PG 7 WC Chemistry, Medicinal; Chemistry, Organic SC Pharmacology & Pharmacy; Chemistry GA AL6FT UT WOS:000339228700029 PM 24969013 ER PT J AU Owens, BD AF Owens, Brett D. TI CORR Insights (R): External Rotation Immobilization for Primary Shoulder Dislocation: A Randomized Controlled Trial SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Editorial Material ID TRAUMATIC ANTERIOR DISLOCATION; RECURRENCE; RISK C1 Keller Army Community Hosp, Dept Orthopaed, West Point, NY 10996 USA. RP Owens, BD (reprint author), Keller Army Community Hosp, Dept Orthopaed, 900 Washington Rd, West Point, NY 10996 USA. EM b.owens@us.army.mil NR 7 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0009-921X EI 1528-1132 J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD AUG PY 2014 VL 472 IS 8 BP 2387 EP 2388 DI 10.1007/s11999-014-3466-4 PG 2 WC Orthopedics; Surgery SC Orthopedics; Surgery GA AL3AK UT WOS:000338997100014 PM 24488751 ER PT J AU Shang, SL Wang, Y Du, Y Tschopp, MA Liu, ZK AF Shang, ShunLi Wang, Yi Du, Yong Tschopp, Mart A. Liu, Zi-Kui TI Integrating computational modeling and first-principles calculations to predict stacking fault energy of dilute multicomponent Ni-base alloys SO COMPUTATIONAL MATERIALS SCIENCE LA English DT Article DE Stacking fault energy; First-principles calculations; CALPHAD modeling approach; Alias shear deformation; Multicomponent Ni-base alloys ID HIGH-TEMPERATURE CREEP; DEFORMATION; METALS; PHASES AB Stacking fault energy (gamma(SF)) for dilute multicomponent Ni-base alloys has been modeled using an integrating CALPHAD (calculation of phase diagram) modeling approach and first-principles alias shear deformation calculations of unary, binary, and ternary alloys. The present first-principles results of gamma(SF) from 55 Ni70X1Y1 (X and Y are 11 alloying elements of Al, Mo, Nb, Os, Re, Ru, Ta, Tc, Ti, V, and W) indicate that the more the structural similarity between X and Y, the smaller the ternary interaction of gamma(SF); and the variation of gamma(SF) due to alloying elements is similar to that of bulk modulus. (C) 2014 Elsevier B.V. All rights reserved. C1 [Shang, ShunLi; Wang, Yi; Liu, Zi-Kui] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. [Du, Yong] Cent S Univ, State Key Lab Powder Met, Changsha 410083, Hunan, Peoples R China. [Tschopp, Mart A.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Shang, SL (reprint author), Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. EM sus26@psu.edu RI Shang, Shun-Li/A-6564-2009; Wang, Yi/D-1032-2013; Liu, Zi-Kui/A-8196-2009; OI Shang, Shun-Li/0000-0002-6524-8897; Liu, Zi-Kui/0000-0003-3346-3696; Tschopp, Mark/0000-0001-8471-5035 FU Office of Naval Research (ONR) of the United States [N0014-07-1-0638]; Center for Computational Materials Design; U.S. NSF Industry/University Cooperative Research Center at Penn State [IIP-1034965]; Georgia Tech [IIP-1034968]; Materials Simulation Center and the Research Computing and Cyber infrastructure unit at Penn State; Office of Science of the US DOE [DE-ACO2-05CH11231]; NSF of China [51028101] FX This work was funded by the Office of Naval Research (ONR) of the United States under contract No. N0014-07-1-0638 and the Center for Computational Materials Design, a joint U.S. NSF Industry/University Cooperative Research Center at Penn State (IIP-1034965) and Georgia Tech (IIP-1034968). First-principles calculations were carried out partially on the LION clusters supported by the Materials Simulation Center and the Research Computing and Cyber infrastructure unit at Penn State, and partially on the resources of NERSC supported by the Office of Science of the US DOE (DE-ACO2-05CH11231). ZKL and YD would like to thank the support from NSF of China (51028101). NR 36 TC 3 Z9 3 U1 6 U2 37 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0927-0256 EI 1879-0801 J9 COMP MATER SCI JI Comput. Mater. Sci. PD AUG PY 2014 VL 91 BP 50 EP 55 DI 10.1016/j.commatsci.2014.04.040 PG 6 WC Materials Science, Multidisciplinary SC Materials Science GA AL4UA UT WOS:000339129100009 ER PT J AU Glasgow, SC Heafner, TA Watson, JDB Aden, JK Perry, WB AF Glasgow, Sean C. Heafner, Thomas A. Watson, J. Devin B. Aden, James K. Perry, W. Brian TI Initial Management and Outcome of Modern Battlefield Anal Trauma SO DISEASES OF THE COLON & RECTUM LA English DT Article DE Anorectal surgery; Ostomy; Outcomes research; Colorectal surgery; General surgery; Trauma ID OPERATION IRAQI FREEDOM; RECTAL INJURIES; SURGICAL-MANAGEMENT; ENDURING FREEDOM; SPHINCTER REPAIR; COMBAT WOUNDS; COLOSTOMY; EPIDEMIOLOGY; COLON AB BACKGROUND: Despite the potential for morbidity and permanent lifestyle alteration, few reports exist examining traumatic injury to the anal canal, particularly among modern-day combatants. OBJECTIVE: The aim of this study was to document the incidence, initial surgical management, and long-term outcomes of wartime anal trauma. DESIGN: This study is a retrospective review. DATA SOURCES: Data were compiled from multiple electronic medical record systems, including the Department of Defense Trauma Registry, the Patient Administration Systems and Biostatistics Activity, and the Armed Forces Health Longitudinal Tracking Application. SETTINGS: Combatants were treated at military treatment facilities with surgical capability during the wars in Iraq and Afghanistan, 2003 through early 2011. PATIENTS: All US and coalition combatants sustaining trauma to the anal canal or sphincter musculature were included. MAIN OUTCOME MEASURES: The quantification of incidence, the evaluation of initial treatment approach, and the determination of clinical and surgical factors correlating with restoration or preservation of GI tract continuity were the primary outcomes measured. RESULTS: Anal trauma occurred in 46 combatants, predominantly from blast injury (76.1%). Most (36, 78.2%) underwent fecal diversion. Concurrent severe systemic or intra-abdominal injuries correlated with colostomy creation. Acute anoplasty was attempted in 11 patients (23.7%) but did not influence eventual colostomy reversal. Among 33 US personnel, the permanent colostomy rate was 30.3%. Concurrent injury to the abdomen strongly predicted long-term colostomy (p = 0.009), along with hypogastric arterial ligation (p = 0.05) and pelvic fracture (p = 0.06). LIMITATIONS: This study was limited by the potential underdiagnosis of anal injury and the restricted follow-up of non-US personnel. CONCLUSIONS: Other injuries besides anal trauma typically have guided the decision for fecal diversion, and acute anal repair has rarely been indicated. The majority of patients with anal trauma regained normal GI continuity, although certain pelvic injuries increased the likelihood of permanent colostomy. C1 [Glasgow, Sean C.] St Louis Univ, Dept Surg, St Louis, MO 63110 USA. [Glasgow, Sean C.] US Air Force, Ctr Sustainment Trauma & Readiness Skills, St Louis, MO USA. [Heafner, Thomas A.; Watson, J. Devin B.] San Antonio Mil Med Ctr, Dept Surg, Ft Sam Houston, TX USA. [Aden, James K.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Perry, W. Brian] Audie L Murphy Vet Hosp, San Antonio, TX USA. RP Glasgow, SC (reprint author), St Louis Univ, Dept Surg, 3635 Vista & Grand Blvd,3 FDT, St Louis, MO 63110 USA. EM glasgowsc@slu.edu FU Defense Health Program [6.7 FY12] FX Research was funded in part by Defense Health Program 6.7 FY12 grant, "Quality of Life and Obstacles to Care in Injured Personnel with Ostomies," principle investigator Major Sean C. Glasgow. NR 32 TC 1 Z9 1 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0012-3706 EI 1530-0358 J9 DIS COLON RECTUM JI Dis. Colon Rectum PD AUG PY 2014 VL 57 IS 8 BP 1012 EP 1018 DI 10.1097/DCR.0000000000000141 PG 7 WC Gastroenterology & Hepatology; Surgery SC Gastroenterology & Hepatology; Surgery GA AL6KO UT WOS:000339241500015 PM 25003297 ER PT J AU Burtnick, MN Brett, PJ DeShazer, D AF Burtnick, Mary N. Brett, Paul J. DeShazer, David TI Proteomic Analysis of the Burkholderia pseudomallei Type II Secretome Reveals Hydrolytic Enzymes, Novel Proteins, and the Deubiquitinase TssM SO INFECTION AND IMMUNITY LA English DT Article ID OUTER-MEMBRANE INTEGRITY; GRAM-NEGATIVE BACTERIA; VIRULENCE IN-VIVO; ESCHERICHIA-COLI; MOLECULAR CHARACTERIZATION; PSEUDOMONAS-PSEUDOMALLEI; MASS-SPECTROMETRY; SIGNAL PEPTIDES; SYSTEM; MALLEI AB Burkholderia pseudomallei, the etiologic agent of melioidosis, is an opportunistic pathogen that harbors a wide array of secretion systems, including a type II secretion system (T2SS), three type III secretion systems (T3SS), and six type VI secretion systems (T6SS). The proteins exported by these systems provide B. pseudomallei with a growth advantage in vitro and in vivo, but relatively little is known about the full repertoire of exoproducts associated with each system. In this study, we constructed deletion mutations in gspD and gspE, T2SS genes encoding an outer membrane secretin and a cytoplasmic ATPase, respectively. The secretion profiles of B. pseudomallei MSHR668 and its T2SS mutants were noticeably different when analyzed by SDS-PAGE. We utilized liquid chromatography-tandem mass spectrometry (LC-MS/MS) to identify proteins present in the supernatants of B. pseudomallei MSHR668 and B. pseudomallei Delta gspD grown in rich and minimal media. The MSHR668 supernatants contained 48 proteins that were either absent or substantially reduced in the supernatants of Delta gspD strains. Many of these proteins were putative hydrolytic enzymes, including 12 proteases, two phospholipases, and a chitinase. Biochemical assays validated the LCMS/MS results and demonstrated that the export of protease, phospholipase C, and chitinase activities is T2SS dependent. Previous studies had failed to identify the mechanism of secretion of TssM, a deubiquitinase that plays an integral role in regulating the innate immune response. Here we present evidence that TssM harbors an atypical signal sequence and that its secretion is mediated by the T2SS. This study provides the first in-depth characterization of the B. pseudomallei T2SS secretome. C1 [Burtnick, Mary N.; Brett, Paul J.] Univ S Alabama, Dept Microbiol & Immunol, Mobile, AL 36688 USA. [DeShazer, David] US Army, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD 21702 USA. RP DeShazer, D (reprint author), US Army, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD 21702 USA. EM david.deshazer.civ@mail.mil FU DTRA/JSTO-CBD [CBCALL12-LS1-2-0070]; National Institute of Allergy and Infectious Diseases [AI065359, AI091783] FX This project received support from DTRA/JSTO-CBD proposal number CBCALL12-LS1-2-0070 (to D.D.). This project was also supported in part by awards AI065359 (to M.N.B) and AI091783 (to P.J.B.) from the National Institute of Allergy and Infectious Diseases. NR 63 TC 14 Z9 14 U1 0 U2 14 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 EI 1098-5522 J9 INFECT IMMUN JI Infect. Immun. PD AUG PY 2014 VL 82 IS 8 BP 3214 EP 3226 DI 10.1128/IAI.01739-14 PG 13 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AL5GK UT WOS:000339161400012 PM 24866793 ER PT J AU Jelacic, TM Chabot, DJ Bozue, JA Tobery, SA West, MW Moody, K Yang, D Oppenheim, JJ Friedlander, AM AF Jelacic, Tanya M. Chabot, Donald J. Bozue, Joel A. Tobery, Steven A. West, Michael W. Moody, Krishna Yang, De Oppenheim, Joost J. Friedlander, Arthur M. TI Exposure to Bacillus anthracis Capsule Results in Suppression of Human Monocyte-Derived Dendritic Cells SO INFECTION AND IMMUNITY LA English DT Article ID D-GLUTAMIC ACID; CHEMOKINE RECEPTOR; CHEMICAL BASIS; HOST-DEFENSE; GUINEA-PIGS; VIVO FATE; IN-VIVO; PEPTIDOGLYCAN; VIRULENCE; ANTIGEN AB The antiphagocytic capsule of Bacillus anthracis is a major virulence factor. We hypothesized that it may also mediate virulence through inhibition of the host's immune responses. During an infection, the capsule exists attached to the bacterial surface but also free in the host tissues. We sought to examine the impact of free capsule by assessing its effects on human monocytes and immature dendritic cells (iDCs). Human monocytes were differentiated into iDCs by interleukin-4 (IL-4) and granulocyte-macrophage colony-stimulating factor (GM-CSF) over 7 days in the presence of capsule derived from wild-type encapsulated B. anthracis Ames (WT) or a control preparation from an isogenic B. anthracis Ames strain that produces only 2% of the capsule of the WT (capA mutant). WT capsule consistently induced release of IL-8 and IL-6 while the capA mutant control preparation elicited either no response or only a minimal release of IL-8. iDCs that were differentiated in the presence of WT capsule had increased side scatter (SSC), a measure of cellular complexity, when assessed by flow cytometry. iDCs differentiated in the presence of WT capsule also matured less well in response to subsequent B. anthracis peptidoglycan (Ba PGN) exposure, with reduced upregulation of the chemokine receptor CCR7, reduced CCR7-dependent chemotaxis, and reduced release of certain cytokines. Exposure of naive differentiated control iDCs to WT capsule did not alter cell surface marker expression but did elicit IL-8. These results indicate that free capsule may contribute to the pathogenesis of anthrax by suppressing the responses of immune cells and interfering with the maturation of iDCs. C1 [Jelacic, Tanya M.; Chabot, Donald J.; Bozue, Joel A.; Tobery, Steven A.; West, Michael W.; Friedlander, Arthur M.] US Army Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Yang, De; Oppenheim, Joost J.] Frederick Natl Lab Canc Res, Mol Immunoregulat Lab, Frederick, MD USA. [Moody, Krishna] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA. RP Jelacic, TM (reprint author), US Army Med Res Inst Infect Dis, Frederick, MD 21702 USA. EM tanya.obreiter@us.army.mil; arthur.friedlander@us.army.mil FU Defense Threat Reduction Agency [CBM.VAXBT.03.10.RD.015] FX The work was supported by the Defense Threat Reduction Agency grant CBM.VAXBT.03.10.RD.015. NR 47 TC 4 Z9 4 U1 4 U2 9 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 EI 1098-5522 J9 INFECT IMMUN JI Infect. Immun. PD AUG PY 2014 VL 82 IS 8 BP 3405 EP 3416 DI 10.1128/IAI.01857-14 PG 12 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AL5GK UT WOS:000339161400029 PM 24891109 ER PT J AU Liu, HN Zhang, Y Chen, YP Wijewarnasuriya, PS AF Liu, Henan Zhang, Yong Chen, Yuanping Wijewarnasuriya, Priyalal S. TI Confocal Micro-PL Mapping of Defects in CdTe Epilayers Grown on Si (211) Substrates with Different Annealing Cycles SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE CdTe; mu-PL; defects; EPD ID MOLECULAR-BEAM EPITAXY; PHOTOLUMINESCENCE; FILMS AB We have applied confocal microphotoluminescence (mu-PL) microscopy to investigate the effects of extended defects in CdTe epilayers grown on (211) Si substrates with different numbers of annealing cycles N. Our results show that the PL dark spot density (PL-DSD) decreases while the spatially averaged PL intensity increases with increasing number of annealing cycles. This is consistent with the general trend that an increase in the number of annealing cycles leads to a reduction of the x-ray diffraction linewidth and etch pit density (EPD). However, direct comparison between the etch pits, imaged by scanning electron microscopy, and PL dark spots on the same sample area results in two important observations: (1) the PL-DSD is substantially higher than the EPD, and (2) not all etch pits appear as dark spots in PL maps. These findings suggest that PL mapping is a more sensitive technique for revealing the extended defects that are actually detrimental to photogenerated carriers, in addition to the apparent advantages of being noninvasive and more efficient. C1 [Liu, Henan; Zhang, Yong] Univ N Carolina, Charlotte, NC 28223 USA. [Chen, Yuanping; Wijewarnasuriya, Priyalal S.] US Army Res Lab, Adelphi, MD USA. RP Liu, HN (reprint author), Univ N Carolina, Charlotte, NC 28223 USA. EM yong.zhang@uncc.edu RI Zhang, Yong/D-3412-2013 FU DARPA/MTO [W911NF-11-2-0070]; Bissell Distinguished Professorship FX This project was supported by DARPA/MTO under Contract # W911NF-11-2-0070, which was monitored by Dr. Nibir Dhar. Yong Zhang acknowledges the support of the Bissell Distinguished Professorship. NR 10 TC 0 Z9 0 U1 2 U2 17 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD AUG PY 2014 VL 43 IS 8 BP 2854 EP 2859 DI 10.1007/s11664-014-3129-y PG 6 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA AL7SH UT WOS:000339334800013 ER PT J AU Shishehchi, S Garrett, GA Rudin, S Wraback, M Bellotti, E AF Shishehchi, Sara Garrett, Gregory A. Rudin, Sergey Wraback, Michael Bellotti, Enrico TI Theoretical and Experimental Study of Time- and Temperature-Dependent Photoluminescence in ZnO SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE Photo-excited carriers; Monte Carlo simulation; ZnO; time-resolved photo-luminescence ID MONTE-CARLO-SIMULATION; PHOTOEXCITED SEMICONDUCTORS; ULTRAFAST RELAXATION; CARRIER DYNAMICS; COHERENT; LUMINESCENCE; GENERATION; TRANSPORT; ELECTRON; GAAS AB In this work, we investigate the dynamics of photo-excited carriers in ZnO. Specifically, we study the luminescence spectrum and the effect of temperature on the luminescence rise time. For comparison, experimental time- resolved photo-luminescence studies on ZnO samples are performed. In the theoretical model, interaction with a laser pulse is treated coherently and a generalized Monte Carlo simulation is used to account for scattering processes. The scattering mechanisms included are carrier interactions with polar optical phonons and acoustic phonons, and carrier-carrier Coulomb interactions. We observed a good agreement between the experimental and simulation results for the photo-luminescence spectrum. Furthermore, as the temperature increases, the luminescence rise time decreases, mostly due to the weaker effect of polar optical scattering at lower temperature. C1 [Shishehchi, Sara; Bellotti, Enrico] Boston Univ, Dept Elect & Comp Engn, Boston, MA 02215 USA. [Garrett, Gregory A.; Rudin, Sergey; Wraback, Michael] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD USA. RP Shishehchi, S (reprint author), Boston Univ, Dept Elect & Comp Engn, 8 St Marys St, Boston, MA 02215 USA. EM bellotti@bu.edu FU U.S. Army Research Laboratory through the Collaborative Research Alliance (CRA) for MultiScale multidisciplinary Modeling of Electronic materials (MSME) FX The work at Boston University has been supported by the U.S. Army Research Laboratory through the Collaborative Research Alliance (CRA) for MultiScale multidisciplinary Modeling of Electronic materials (MSME). NR 22 TC 0 Z9 0 U1 3 U2 23 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD AUG PY 2014 VL 43 IS 8 BP 3033 EP 3040 DI 10.1007/s11664-014-3188-0 PG 8 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA AL7SH UT WOS:000339334800037 ER PT J AU Peiris, FC Brill, G Doyle, K VanMil, B Myers, TH AF Peiris, F. C. Brill, G. Doyle, Kevin VanMil, Brenda Myers, Thomas H. TI Exploring the Optical Properties of Hg1-x Cd-x Se Films Using IR-Spectroscopic Ellipsometry SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE HgCdSe; ellipsometry; dielectric function; doping AB We have used infrared spectroscopic ellipsometry to interrogate the dielectric response of a series of Hg1-x Cd (x) Se samples in a spectral range between 2000 and 40000 nm. Using a standard inversion technique, the experimental data obtained at multiple angles of incidence were modeled to deduce the dielectric function of each sample. The dielectric functions obtained for Hg1-x Cd (x) Se samples allowed us to predict the band gaps for the samples, which increase as a function of the Cd concentration. Next, we modeled the dielectric function as a collection of oscillators, each of which represented a particular transition manifested in the spectrum. The most significant result obtained from this work is the recovery of their doping characteristics from the ellipsometric data. Specifically, two Hg1-x Cd (x) Se samples with x = 0.21 and 0.28, grown on GaSb substrates, show a carrier concentration of 1.6 x 10(17) and 1.8 x 10(18) cm(-3), respectively. These results are particularly helpful because conventional Hall measurements cannot be used for these specific samples due to the substrates (i.e., GaSb) used to grow them being highly conductive. C1 [Peiris, F. C.] Kenyon Coll, Dept Phys, Gambier, OH 43022 USA. [Brill, G.; Doyle, Kevin; VanMil, Brenda] US Army Res Lab, Adelphi, MD 20783 USA. [Myers, Thomas H.] Texas State Univ San Marcos, Dept Phys, San Marcos, TX 78666 USA. RP Peiris, FC (reprint author), Kenyon Coll, Dept Phys, Gambier, OH 43022 USA. EM peirisf@kenyon.edu RI Myers, Thomas/C-3769-2013 FU National Science Foundation [DMR-1207169]; U.S. Army Research Laboratory; U.S. Army Research Office [W911NF-10-2-0103, W911NF-10-1-0335, W911NF-12-2-0019] FX The work at Kenyon was funded by the National Science Foundation DMR-1207169 grant. Support for the growth and study of the Hg1-xCdxSe samples was provided by the U.S. Army Research Laboratory and the U.S. Army Research Office under contract/grant numbers W911NF-10-2-0103, W911NF-10-1-0335, and W911NF-12-2-0019. NR 13 TC 2 Z9 3 U1 2 U2 9 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD AUG PY 2014 VL 43 IS 8 BP 3056 EP 3059 DI 10.1007/s11664-014-3208-0 PG 4 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA AL7SH UT WOS:000339334800040 ER PT J AU Jayakumar, P Melanz, D MacLennan, J Gorsich, D Senatore, C Iagnemma, K AF Jayakumar, Paramsothy Melanz, Daniel MacLennan, Jamie Gorsich, David Senatore, Carmine Iagnemma, Karl TI Scalability of classical terramechanics models for lightweight vehicle applications incorporating stochastic modeling and uncertainty propagation SO JOURNAL OF TERRAMECHANICS LA English DT Article DE Terramechanics; Robotic vehicles; Bekker and Wong models; Soil test bed; Uncertainty propagation; Stochastic modeling ID TERRAIN AB This paper investigates the validity of commonly used terramechanics models for lightweight vehicle applications while accounting for experimental variability. This is accomplished by cascading uncertainty up to the point of wheel performance. Vehicle-terrain interaction is extremely complex, and thus models and simulation methods for vehicle mobility prediction are largely based on empirical data. Analytical methods are compared to experimental measurements of key operational parameters such as drawbar force, torque, and sinkage. Models of operational parameters ultimately depend on a small set of empirically determined soil parameters, each with an inherent uncertainty due to test variability. The soil parameters associated with normal loads are determined by fitting the dimensionless form of Bekker's equation to the pressure-sinkage test data. Similarly, the soil parameters associated with shear loads are determined by fitting Janosi-Hanamoto's equation to the direct shear test data. An uncertainty model is used to propagate the soil parameter variability through to the wheel performance based on Wong and Reece. This commonly used analytical model is shown to be inaccurate as the envelope of model uncertainty does not lie within the experimental measures, suggesting that model improvements are required to accurately predict the performance of lightweight vehicles on deformable terrain. Published by Elsevier Ltd. on behalf of ISTVS. C1 [Jayakumar, Paramsothy; Melanz, Daniel; MacLennan, Jamie; Gorsich, David] US Army TARDEC, Warren, MI 48092 USA. [Senatore, Carmine; Iagnemma, Karl] MIT, Cambridge, MA 02139 USA. RP Jayakumar, P (reprint author), US Army TARDEC, Warren, MI 48092 USA. EM Paramsothy.Jayakumar.civ@mail.mil NR 20 TC 2 Z9 3 U1 2 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4898 EI 1879-1204 J9 J TERRAMECHANICS JI J. Terramech. PD AUG PY 2014 VL 54 BP 37 EP 57 DI 10.1016/j.jterra.2014.04.004 PG 21 WC Engineering, Environmental SC Engineering GA AL6CQ UT WOS:000339220300003 ER PT J AU Drost, RJ Sadler, BM AF Drost, Robert J. Sadler, Brian M. TI Survey of ultraviolet non-line-of-sight communications SO SEMICONDUCTOR SCIENCE AND TECHNOLOGY LA English DT Article DE ultraviolet; communications; non-line-of-sight; free-space optical communications ID SCATTER PROPAGATION MODEL; SOLAR-BLIND; NONCOPLANAR GEOMETRY; UV COMMUNICATION; PATH LOSS; RANGE; PERFORMANCE; RADIATION; CHANNELS; NETWORK AB The unique characteristics of the atmospheric propagation of deep ultraviolet (UV) radiation make possible the novel capability of establishing non-line-of-sight (NLOS) optical communication links. Although NLOS UV communications (UVC) has been studied for decades, early work focused on the use of lasers and flash lamps as sources. Recent advances in device technology, including UV light-emitting diodes and solar-blind optical filters, suggest that compact low-power systems may soon be feasible, and, as a result, research into the effective use of this rapidly maturing technology has accelerated. In this paper, we review the NLOS UVC literature, examining a range of topics from channel modelling and experimentation through system analysis and prototype development. The breadth of this research not only indicates the growing interest in UVC technology but also suggests the existence of many avenues for continued exploration. C1 [Drost, Robert J.; Sadler, Brian M.] Army Res Lab, Adelphi, MD 20783 USA. RP Drost, RJ (reprint author), Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM robert.j.drost6.civ@mail.mil NR 57 TC 12 Z9 13 U1 4 U2 33 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0268-1242 EI 1361-6641 J9 SEMICOND SCI TECH JI Semicond. Sci. Technol. PD AUG PY 2014 VL 29 IS 8 AR 084006 DI 10.1088/0268-1242/29/8/084006 PG 11 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Condensed Matter SC Engineering; Materials Science; Physics GA AL6LE UT WOS:000339243300009 ER PT J AU Shatalov, M Sun, WH Jain, R Lunev, A Hu, XH Dobrinsky, A Bilenko, Y Yang, JW Garrett, GA Rodak, LE Wraback, M Shur, M Gaska, R AF Shatalov, Max Sun, Wenhong Jain, Rakesh Lunev, Alex Hu, Xuhong Dobrinsky, Alex Bilenko, Yuri Yang, Jinwei Garrett, Gregory A. Rodak, Lee E. Wraback, Michael Shur, Michael Gaska, Remis TI High power AlGaN ultraviolet light emitters SO SEMICONDUCTOR SCIENCE AND TECHNOLOGY LA English DT Article DE ultraviolet; nitrides; light-emitting diodes; semiconductor; quantum wells ID ALN; DISLOCATIONS AB We present the analysis of the external quantum efficiency in AlGaN deep ultraviolet (DUV) light-emitting diodes (LEDs) on sapphire substrates and discuss factors affecting the output power of DUV LEDs. Performance of the LED is related to optimization of the device structure design and improvements of the epitaxial material quality. C1 [Shatalov, Max; Sun, Wenhong; Jain, Rakesh; Lunev, Alex; Hu, Xuhong; Dobrinsky, Alex; Bilenko, Yuri; Yang, Jinwei; Gaska, Remis] Sensor Elect Technol Inc, Columbia, SC 29209 USA. [Garrett, Gregory A.; Rodak, Lee E.; Wraback, Michael] US Army, Res Lab, Adelphi, MD 20783 USA. [Shur, Michael] Rensselaer Polytech Inst, Dept Elect Comp & Syst Engn, Troy, NY 12180 USA. [Shur, Michael] Rensselaer Polytech Inst, Ctr Integrated Elect, Troy, NY 12180 USA. RP Shatalov, M (reprint author), Sensor Elect Technol Inc, 1195 Atlas Rd, Columbia, SC 29209 USA. EM shatalov@s-et.com RI Shur, Michael/A-4374-2016 OI Shur, Michael/0000-0003-0976-6232 FU DARPA CMUVT program; Army Research Laboratory under ARL MSME Alliance FX This work was partially supported by the DARPA CMUVT program monitored by Dr D Green. The work at RPI was also partially supported by the Army Research Laboratory under ARL MSME Alliance (Project Monitor Dr Meredith Reed). NR 29 TC 41 Z9 41 U1 6 U2 47 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0268-1242 EI 1361-6641 J9 SEMICOND SCI TECH JI Semicond. Sci. Technol. PD AUG PY 2014 VL 29 IS 8 AR 084007 DI 10.1088/0268-1242/29/8/084007 PG 6 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Condensed Matter SC Engineering; Materials Science; Physics GA AL6LE UT WOS:000339243300010 ER PT J AU Nadler, R Convertino, VA Gendler, S Lending, G Lipsky, AM Cardin, S Lowenthal, A Glassberg, E AF Nadler, Roy Convertino, Victor A. Gendler, Sami Lending, Gadi Lipsky, Ari M. Cardin, Sylvain Lowenthal, Alexander Glassberg, Elon TI THE VALUE OF NONINVASIVE MEASUREMENT OF THE COMPENSATORY RESERVE INDEX IN MONITORING AND TRIAGE OF PATIENTS EXPERIENCING MINIMAL BLOOD LOSS SO SHOCK LA English DT Article DE Compensatory reserve index; prehospital; triage; hemorrhage ID HEART-RATE-VARIABILITY; COMBAT CASUALTY CARE; EN-ROUTE CARE; CENTRAL HYPOVOLEMIA; SHOCK INDEX; TRAUMA; MORTALITY; MILITARY; TOOL AB Currently available triage and monitoring tools are often late to detect life-threatening clinically significant physiological aberrations and provide limited data in prioritizing bleeding patients for treatment and evacuation. The Compensatory Reserve Index (CRI) is a novel means of assessing physiologic reserve, shown to correlate with central blood volume loss under laboratory conditions. The purpose of this study was to compare the noninvasive CRI device with currently available vital signs in detecting blood loss. Study subjects were soldiers volunteering for blood donation (n = 230), and the control group was composed of soldiers who did not donate blood (n = 34). Data collected before and after blood donation were compared, receiver operator characteristic curves were generated after either donation or the appropriate time interval, and areas under the curves (AUCs) were compared. Compared with pre-blood loss, blood donation resulted in a mean reduction of systolic blood pressure by 3% (before, 123 mmHg; after, 119 mmHg; P < 0.01). The CRI demonstrated a 16% reduction (before, 0.74; after, 0.62; P < 0.01). Heart rate, diastolic blood pressure, and oxygen saturation remained unchanged. The AUC for change in CRI was 0.81, 0.56 for change in heart rate, 0.53 for change in systolic blood pressure, 0.55 and 0.58 for pulse pressure and shock index, respectively. The AUCs for detecting mild blood loss at a single measurement were 0.73 for heart rate, 0.60 for systolic blood pressure, 0.62 for diastolic blood pressure, 0.45 for pulse oximetry, and 0.84 for CRI. The CRI was better than standard indices in detecting mild blood loss. Single measurement of CRI may enable a more accurate triage, and CRI monitoring may allow for earlier detection of casualty deterioration. C1 [Nadler, Roy; Gendler, Sami; Lending, Gadi; Lipsky, Ari M.; Glassberg, Elon] Israeli Def Forces, Trauma & Combat Med Branch, Surg Gen Headquarters, Ramat Gan, Israel. [Convertino, Victor A.; Cardin, Sylvain] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Lipsky, Ari M.] Rambam Hlth Care Campus, Dept Emergency Med, Haifa, Israel. [Lowenthal, Alexander] Schneider Childrens Med Ctr Israel, Dept Pediat Cardiol, Petah Tiqwa, Israel. RP Glassberg, E (reprint author), Israeli Def Forces, Trauma & Combat Med Branch, Med Corps, Surg Gen Headquarters, Mil POB 02149, Ramat Gan, Israel. EM idf_trauma@idf.gov.il NR 26 TC 11 Z9 11 U1 0 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD AUG PY 2014 VL 42 IS 2 BP 93 EP 98 DI 10.1097/SHK.0000000000000178 PG 6 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA AL6MB UT WOS:000339245700003 PM 24667628 ER PT J AU Liu, NT Holcomb, JB Wade, CE Darrah, MI Salinas, J AF Liu, Nehemiah T. Holcomb, John B. Wade, Charles E. Darrah, Mark I. Salinas, Jose TI UTILITY OF VITAL SIGNS, HEART RATE VARIABILITY AND COMPLEXITY, AND MACHINE LEARNING FOR IDENTIFYING THE NEED FOR LIFESAVING INTERVENTIONS IN TRAUMA PATIENTS SO SHOCK LA English DT Article DE Machine learning; lifesaving interventions; heart rate complexity; heart rate variability; trauma ID SAMPLE ENTROPY; PREDICTION; SHOCK; HELICOPTERS; OUTCOMES; TRIAGE; IMPACT; NOISE AB To date, no studies have attempted to utilize data from a combination of vital signs, heart rate variability and complexity (HRV, HRC), as well as machine learning (ML), for identifying the need for lifesaving interventions (LSIs) in trauma patients. The objectives of this study were to examine the utility of the above for identifying LSI needs and compare different LSI-associated models, with the hypothesis that an ML model would be superior in performance over multivariate logistic regression models. One hundred four patients transported from the injury scene via helicopter were selected for the study. A wireless vital signs monitor was attached to the patient's arm and used to capture physiologic data, including HRV and HRC. The power of vital sign measurements, HRV, HRC, and Glasgow Coma Scale score (GCS) to identify patients requiring LSIs was estimated using multivariate logistic regression and ML. Receiver operating characteristic (ROC) curves were also obtained. Thirty-two patients underwent 75 LSIs. After logistic regression, ROC curves demonstrated better identification for LSIs using heart rate (HR) and HRC (area under the curve [AUC] of 0.81) than using HR alone (AUC of 0.73). Likewise, ROC curves demonstrated better identification for LSIs using GCS and HRC (AUC of 0.94) than using GCS and HR (AUC of 0.92). Importantly, ROC curves demonstrated that an ML model using HR, GCS, and HRC (AUC of 0.99) had superior performance over multivariate logistic regression models for identifying the need for LSIs in trauma patients. Development of computer decision support systems should utilize vital signs, HRC, and ML in order to achieve more accurate diagnostic capabilities, such as identification of needs for LSIs in trauma patients. C1 [Liu, Nehemiah T.; Salinas, Jose] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Holcomb, John B.; Wade, Charles E.] Univ Texas Hlth Sci Ctr Houston, Ctr Translat Injury Res, Dept Surg, Houston, TX 77030 USA. [Darrah, Mark I.] Athena GTX Inc, Des Moines, IA USA. RP Liu, NT (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA. EM nehemiah.liu@us.army.mil FU National Trauma Institute; Combat Casualty Care Research Program; State of Texas Emerging Technology Fund FX This work was supported by the National Trauma Institute, the Combat Casualty Care Research Program, and the State of Texas Emerging Technology Fund. NR 30 TC 9 Z9 10 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD AUG PY 2014 VL 42 IS 2 BP 108 EP 114 DI 10.1097/SHK.0000000000000186 PG 7 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA AL6MB UT WOS:000339245700005 PM 24727872 ER PT J AU Rani, M Zhang, Q Schwacha, MG AF Rani, Meenakshi Zhang, Qiong Schwacha, Martin G. TI GAMMA DELTA T CELLS REGULATE WOUND MYELOID CELL ACTIVITY AFTER BURN SO SHOCK LA English DT Article DE Injury; inflammation; macrophage; MDSC; cytokines ID SYSTEMIC INFLAMMATORY RESPONSE; THERMAL-INJURY; SUPPRESSOR-CELLS; IMMUNE-SYSTEM; MACROPHAGE HYPERACTIVITY; UP-REGULATION; MURINE MODEL; IMMUNOSUPPRESSION; LYMPHOCYTES; DYSFUNCTION AB Major burns induce immune complications, which are associated with myeloid cell activation by ill-defined mechanisms. Although gamma delta T cells have been shown to be important in postinjury inflammation and wound healing, their role in the regulation of myeloid cells remains unknown. To study this, wild-type (WT) and gamma delta T cell-deficient (delta TCR-/-) mice were subjected to major burn (25% total body surface area, third degree) or sham treatment. At 3 days thereafter, skin samples were assayed for cytokine content or used to isolate single cells that were used for myeloid cell characterization by flow cytometry. The number of CD11b(+) myeloid cells increased by approximately 75% in the wound skin of WT mice. This influx was caused by increased myeloid-derived suppressor cells (CD11b(+) GR1(+)) whose numbers increased 19-fold compared with those of sham skin. In contrast, macrophage (MO; CD11b(+) F4/80(+)) numbers decreased by approximately 50% after burn. In delta TCR-/- mice, burn increased the myeloid cell numbers approximately 5-fold. The increase in myeloid cells at the injury site of delta TCR-/- mice was caused by both a myeloid-derived suppressor cell (50-fold) and a MO (2-fold) influx. Burn increased skin cytokine levels for a number of prototypic inflammatory cytokines (interleukin 1 beta, interleukin 6, tumor necrosis factor-alpha, macrophage inflammatory protein [MIP] 1 beta, etc). Tumor necrosis factor-alpha, MIP-alpha, and MIP-1 beta levels were further elevated (2- to 3-fold) in the injured skin of delta TCR-/- mice compared with those of WT mice. In conclusion, these data show that gamma delta T cells regulate myeloid cell infiltration of the wound site and act to quell inflammation, thereby promoting the transition to the proliferative phase of wound healing. C1 [Rani, Meenakshi; Zhang, Qiong; Schwacha, Martin G.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA. [Schwacha, Martin G.] US Army Inst Surg Res, Ft Sam Houston, TX USA. RP Schwacha, MG (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, Mail Code 7740,7703 Floyd Curl Dr, San Antonio, TX 78229 USA. EM schwacha@uthscsa.edu FU National Institutes of Health [GM079122] FX This study was supported by the National Institutes of Health (grant no. GM079122). NR 43 TC 8 Z9 9 U1 2 U2 10 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD AUG PY 2014 VL 42 IS 2 BP 133 EP 141 DI 10.1097/SHK.0000000000000176 PG 9 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA AL6MB UT WOS:000339245700009 PM 24667623 ER PT J AU Qiao, L Hong, Y McPherson, R Shafer, M Gade, D Williams, D Chen, S Lilly, D AF Qiao, Lei Hong, Yang McPherson, Renee Shafer, Mark Gade, David Williams, David Chen, Sheng Lilly, Douglas TI Climate Change and Hydrological Response in the Trans-State Oologah Lake Watershed-Evaluating Dynamically Downscaled NARCCAP and Statistically Downscaled CMIP3 Simulations with VIC Model SO WATER RESOURCES MANAGEMENT LA English DT Article DE Climate change; NARCCAP; Statistical downscaling; VIC; Oologah Lake watershed ID SOIL-MOISTURE; UNITED-STATES; RIVER-BASIN; PARAMETERIZATION; PRECIPITATION; PERFORMANCE; SCHEMES; IMPACTS; PROJECT; RUNOFF AB Statistically and dynamically downscaled climate projections are the two important data sources for evaluation of climate change and its impact on water availability, water quality and ecosystems. Though bias correction helps to adjust the climate model output to behave more similarly to observations, the hydrologic response still can be biased. This study uses Variable Infiltration Capacity (VIC) model to evaluate the hydrologic response of the trans-state Oologah Lake watershed to climate change by using both statistically and dynamically downscaled multiple climate projections. Simulated historical and projected climate data from the North American Regional Climate Change Assessment Program (NARCCAP) and Bias-Corrected and Spatially Downscaled-Coupled Model Intercomparison Phase 3 (BCSD-CMIP3) forced the hydrologic model. In addition, different river network upscaling methods are also compared for a higher VIC model performance. Evaluation and comparison shows the following the results. (1) From the hydrologic point of view, the dynamically downscaled NARCCAP projection performed better, most likely in capturing a larger portion of mesoscale-driven convective rainfall than the statistically downscaled CMIP3 projections; hence, the VIC model generated higher seasonal streamflow amplitudes that are closer to observations. Additionally, the statistically downscaled GCMs are less likely to capture the hydrological simulation probably due to missing integration of climate variables of wind, solar radiation and others, even though their precipitation and temperature are bias corrected to be more favorably than the NARCCAP simulations. (2) Future water availability (precipitation, runoff, and baseflow) in the watershed would increase annually by 3-4 %, suggested by both NARCCAP and BCSD-CMIP3. Temperature increases (2.5-3 degrees C) are much more consistent between the two types of climate projections both seasonally and annually. However, NARCCAP suggested 2-3 times higher seasonal variability of precipitation and other water fluxes than the BCSD-CMIP3 models. (3) The hydrologic performance could be used as a potential metric to comparatively differentiate climate models, since the land surface and atmosphere processes are considered integrally. C1 [Qiao, Lei; Hong, Yang; Chen, Sheng] Univ Oklahoma, Sch Civil Engn & Environm Sci, Norman, OK 73019 USA. [Qiao, Lei; Hong, Yang; Chen, Sheng] Univ Oklahoma, Adv Radar Res Ctr, Norman, OK 73019 USA. [Qiao, Lei] Oklahoma State Univ, Dept Nat Resource Ecol & Management, Stillwater, OK 74078 USA. [McPherson, Renee; Shafer, Mark] Univ Oklahoma, Oklahoma Climatol Survey, Norman, OK 73019 USA. [McPherson, Renee; Shafer, Mark] Univ Oklahoma, Dept Geog & Environm Sustainabil, Norman, OK 73019 USA. [Gade, David; Williams, David; Lilly, Douglas] US Army Corps Engineers, Tulsa Dist, OK USA. [Hong, Yang] Tsinghua Univ, Dept Hydraul Engn, Beijing 100084, Peoples R China. [Hong, Yang] Natl Weather Ctr, Adv Radar Res Ctr, Hydrometeorol & Remote Sensing Lab Hydro Ou Edu, Norman, OK 73072 USA. RP Hong, Y (reprint author), Natl Weather Ctr, Adv Radar Res Ctr, Hydrometeorol & Remote Sensing Lab Hydro Ou Edu, Suite 4610,120 David L Boren Blvd, Norman, OK 73072 USA. EM yanghong@ou.edu RI McPherson, Renee/H-6256-2016; Hong, Yang/D-5132-2009 OI McPherson, Renee/0000-0002-1497-9681; Hong, Yang/0000-0001-8720-242X FU Responses to Climate Change program; U.S. Army Corps of Engineers Institute for Water Resources; South Central Climate Science Center; U.S. Geological Survey FX This research was funded by the Responses to Climate Change program, U.S. Army Corps of Engineers Institute for Water Resources and the South Central Climate Science Center, U.S. Geological Survey. We wish to thank the North American Regional Climate Change Assessment Program (NARCCAP) for providing the data used in this paper. "Bias Corrected and Downscaled WCRP CMIP3 Climate Projections" archive at http://gdo-dcp.ucllnl.org/downscaled_cmip3_ projections/. NR 47 TC 10 Z9 10 U1 4 U2 28 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0920-4741 EI 1573-1650 J9 WATER RESOUR MANAG JI Water Resour. Manag. PD AUG PY 2014 VL 28 IS 10 BP 3291 EP 3305 DI 10.1007/s11269-014-0678-z PG 15 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA AK8BC UT WOS:000338651100035 ER PT J AU Tarney, CM Wilson, K Sewell, MF AF Tarney, Christopher M. Wilson, Karen Sewell, Mark F. TI Cogan Syndrome in Pregnancy SO OBSTETRICS AND GYNECOLOGY LA English DT Article AB BACKGROUND: Cogan syndrome is a rare, multisystem, autoimmune disorder of unknown etiology. Little is known about whether it affects pregnancy or whether pregnancy affects the disease. CASE: A 24-year-old primigravid woman with Cogan syndrome diagnosed 3 years before her pregnancy presented to our clinic for prenatal care. During pregnancy she experienced no worsening of symptoms of her disease but reported subjective improvement in vision and hearing. Cesarean delivery was performed at term because of nonreassuring fetal status. There were no obstetric or postpartum complications. CONCLUSION: Cogan syndrome requires close monitoring. If it worsens, then the disease process can be similar to both physiologic and pathologic changes of pregnancy. However, unlike the former, worsening Cogan syndrome can have irreversible maternal consequences. C1 [Tarney, Christopher M.] Womack Army Med Ctr, Dept Obstet & Gynecol, 2817 Reilly Rd, Ft Bragg, NC 28307 USA. Womack Army Med Ctr, Dept Obstet & Gynecol, Div Maternal Fetal Med, Ft Bragg, NC 28307 USA. RP Tarney, CM (reprint author), Womack Army Med Ctr, Dept Obstet & Gynecol, 2817 Reilly Rd, Ft Bragg, NC 28307 USA. EM christopher.tarney@us.army.mil NR 9 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD AUG PY 2014 VL 124 IS 2 SU 1 BP 428 EP 431 DI 10.1097/AOG.0000000000000390 PN 2 PG 5 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA V42GI UT WOS:000209601900008 PM 25004327 ER PT J AU Hearn, AR Chapman, ED Singer, GP Brostoff, WN LaCivita, PE Klimley, AP AF Hearn, Alex R. Chapman, Eric D. Singer, Gabriel P. Brostoff, William N. LaCivita, Peter E. Klimley, A. Peter TI Movements of out-migrating late-fall run Chinook salmon (Oncorhynchus tshawytscha) smolts through the San Francisco Bay Estuary SO ENVIRONMENTAL BIOLOGY OF FISHES LA English DT Article DE Acoustic tags; Telemetry; Chinook salmon; Tidal flows; Migration; Sacramento River; San Francisco Bay Estuary ID CENTRAL VALLEY; JUVENILE SALMONIDS; RIVER ESTUARY; CALIFORNIA; SURVIVAL; HATCHERY; ECOLOGY; MYKISS; GROWTH; DELTA AB One thousand late-fall run Chinook salmon (Oncorhynchus tshawytscha) hatchery reared smolts were fitted with ultrasonic coded tags over a two-year period (in 2009 and 2010) and released in the Sacramento River. We tracked their outmigration movements from Benicia Bridge to the Golden Gate. Smolts transited the Bay rapidly in 2 to 4 days, yet also made repeated upstream movements, coinciding with incoming tidal flows. Most smolts were detected in deep, channelized portions of the Bay. Some smolts were detected at nearshore, shallow sites such as marinas, or up tributaries, yet these fish generally returned to the main channel and continued their outmigration. The results suggest that the smolts perceive little benefit to remaining in estuarine waters, and therefore actively attempt to reach the ocean in as short a time as possible, rather than being transported passively by flows. C1 [Hearn, Alex R.; Chapman, Eric D.; Singer, Gabriel P.; Klimley, A. Peter] Univ Calif Davis, Dept Wildlife Fish & Conservat Biol, Davis, CA 95616 USA. [Brostoff, William N.; LaCivita, Peter E.] US Army Corps Engineers, San Francisco, CA 94103 USA. RP Hearn, AR (reprint author), Univ Calif Davis, Dept Wildlife Fish & Conservat Biol, 1331,Acad Surge,1 Shields Ave, Davis, CA 95616 USA. EM arhearn@ucdavis.edu FU US Army Corps of Engineers, San Francisco District FX This study was funded by the US Army Corps of Engineers, San Francisco District, to provide information to the Long Term Management Strategy (LTMS) for fish movement in San Francisco Bay relative to dredging and dredged material placement operations. The authors would like to thank Chuck Morton and Charlotte Cashin for scheduling boat time and assisting on the Caltrans vessel with the maintenance of the monitors deployed on the Bay Bridge and Richmond San Rafael Bridge. We appreciate the help from everyone at the UC Davis Biotelemetry Laboratory (Mike Thomas, Denise Tu, Michelle Buckhorn, Anna Steel and Jamilynn Poletto) for volunteering their time to assist with the surgical implantation of the tags and for assistance in maintaining the arrays. We would also like to thank Arnold Ammann and Cyril Michel at the Santa Cruz office of the NMFS for maintaining the database. Thanks to Kurt Brown and Kevin Niemela at the Coleman National Fish Hatchery. All fish handling protocols were approved under UC Davis Animal Care Protocol #15486. NR 33 TC 2 Z9 2 U1 2 U2 24 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0378-1909 EI 1573-5133 J9 ENVIRON BIOL FISH JI Environ. Biol. Fishes PD AUG PY 2014 VL 97 IS 8 BP 851 EP 863 DI 10.1007/s10641-013-0184-9 PG 13 WC Ecology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA AK2EM UT WOS:000338231900001 ER PT J AU Ferguson, JB Lopez, HF Rohatgi, PK Cho, K Kim, CS AF Ferguson, J. B. Lopez, Hugo F. Rohatgi, Pradeep K. Cho, Kyu Kim, Chang-Soo TI Impact of Volume Fraction and Size of Reinforcement Particles on the Grain Size in Metal-Matrix Micro and Nanocomposites SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE LA English DT Article ID MECHANICAL-PROPERTIES; ALUMINUM-ALLOY; MG; STRENGTH; COMPOSITE; MICROSTRUCTURE; BEHAVIOR; TENSILE; MMNCS AB In metal-matrix micro and nanocomposites (MMCs and MMNCs), the presence and interactions of various strengthening mechanisms are not well understood, but grain boundary strengthening is considered as one of the primary means of improving the yield strength of composites. Owing to the importance of grain size on mechanical properties, it is necessary to be able to describe how incorporation of nanoparticles (NPs) in both powder metallurgy (PM) and solidification processing (SP) affects this critical property. In the present work, we provide a basis for an empirical equation that relates particle fraction and particle size to MMNC grain size for both PM and SP synthesis methods. The model suggests that NPs retard grain coarsening in PM MMNCs and also seems to describe the effect of reinforcement concentration on grain size in SP MMCs and MMNCs. C1 [Ferguson, J. B.; Lopez, Hugo F.; Rohatgi, Pradeep K.; Kim, Chang-Soo] Univ Wisconsin, Mat Sci & Engn Dept, Milwaukee, WI 53211 USA. [Cho, Kyu] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Ferguson, JB (reprint author), Univ Wisconsin, Mat Sci & Engn Dept, Milwaukee, WI 53211 USA. EM kimcs@uwm.edu FU U.S. Army Research Laboratory [W911NF-08-2-0014] FX This material is based upon work supported by the U.S. Army Research Laboratory under Cooperative Agreement No. W911NF-08-2-0014. The views, opinions, and conclusions made in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of Army Research Laboratory or the U. S. Government. The U. S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 21 TC 5 Z9 5 U1 2 U2 11 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1073-5623 EI 1543-1940 J9 METALL MATER TRANS A JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci. PD AUG PY 2014 VL 45A IS 9 BP 4055 EP 4061 DI 10.1007/s11661-014-2358-2 PG 7 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA AK2VM UT WOS:000338277600036 ER PT J AU Zheng, ZL Badawy, T Henein, N Sattler, E Johnson, N AF Zheng, Ziliang Badawy, Tamer Henein, Naeim Sattler, Eric Johnson, Nicholas TI Effect of Cetane Improver on Autoignition Characteristics of Low Cetane Sasol IPK Using Ignition Quality Tester SO JOURNAL OF ENGINEERING FOR GAS TURBINES AND POWER-TRANSACTIONS OF THE ASME LA English DT Article ID FUEL; EMISSIONS; NUMBER AB This paper investigates the effect of a cetane improver on the autoignition characteristics of Sasol IPK in the combustion chamber of the ignition quality tester (IQT). The fuel tested was Sasol IPK with a derived cetane number (DCN) of 31, treated with different percentages of Lubrizol 8090 cetane improver ranging from 0.1 to 0.4%. Tests were conducted under steady state conditions at a constant charging pressure of 21 bar. The charge air temperature before fuel injection varied from 778 to 848 K. Accordingly, all the tests were conducted under a constant charge density. The rate of heat release was calculated and analyzed in detail, particularly during the autoignition period. In addition, the physical and chemical delay periods were determined by comparing the results of two tests. The first was conducted with fuel injection into air according to ASTM standards where combustion occurred. In the second test, the fuel was injected into the chamber charged with nitrogen. The physical delay is defined as the period of time from start of injection (SOI) to point of inflection (POI), and the chemical delay is defined as the period of time from POI to start of combustion (SOC). Both the physical and chemical delay periods were determined under different charge temperatures. The cetane improver was found to have an effect only on the chemical ID period. In addition, the effect of the cetane improver on the apparent activation energy of the global combustion reactions was determined. The results showed a linear drop in the apparent activation energy with the increase in the percentage of the cetane improver. Moreover, the low temperature (LT) regimes were investigated and found to be presented in base fuel, as well as cetane improver treated fuels. C1 [Zheng, Ziliang; Badawy, Tamer; Henein, Naeim] Wayne State Univ, Detroit, MI 48202 USA. [Sattler, Eric; Johnson, Nicholas] US Army RDECOM TARDEC, Warren, MI 48397 USA. RP Zheng, ZL (reprint author), Wayne State Univ, 5050 Anthony Wayne Dr,Suite 2100, Detroit, MI 48202 USA. EM zhengziliang@gmail.com; eng.tam@gmail.com; henein@eng.wayne.edu FU U.S. Army TARDEC and National Automotive Center (NAC); U.S. Department of Energy, Next Energy Center and Automotive Research Center (ARC): ARC is a Center of Excellence in Simulation and Modeling; U.S. Army TARDEC FX This research was sponsored by the U.S. Army TARDEC and National Automotive Center (NAC), the U.S. Department of Energy, Next Energy Center and Automotive Research Center (ARC): ARC is a Center of Excellence in Simulation and Modeling sponsored by the U.S. Army TARDEC and lead by the University of Michigan. Our special thanks go to Patsy Muzzell, P. Schihl and L. Hoogterp-Decker of TARDEC, as well as Kapila Wadumesthrige and Elena Florea for their technical support. Also, we would like to thank Dr. Bradley Zigler of the National Renewable Energy Lab for his technical support, and Wayne State University Center of Automotive Research members for their help in conducting this research. NR 41 TC 4 Z9 4 U1 1 U2 4 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0742-4795 EI 1528-8919 J9 J ENG GAS TURB POWER JI J. Eng. Gas. Turbines Power-Trans. ASME PD AUG PY 2014 VL 136 IS 8 AR 081505 DI 10.1115/1.4026812 PG 11 WC Engineering, Mechanical SC Engineering GA AJ8JU UT WOS:000337950300006 ER PT J AU Chen, IR Guo, J Sao, FY Cho, JH AF Chen, Ing-Ray Guo, Jia Sao, Fenye Cho, Jin-Hee TI Trust management in mobile ad hoc networks for bias minimization and application performance maximization SO AD HOC NETWORKS LA English DT Article DE Trust management; Mobile ad hoc networks; Trust bias minimization; Model-based analysis; Application-level trust optimization; Reliability assessment ID DELAY-TOLERANT NETWORKS; ADMISSION CONTROL ALGORITHMS; FORWARDING STRATEGIES; LOCATION MANAGEMENT; MULTIMEDIA SERVERS; WIRELESS; OPTIMIZATION; RELIABILITY; SYSTEM; SOFTWARE AB Trust management for mobile ad hoc networks (MANETs) has emerged as an active research area as evidenced by the proliferation of trust/reputation protocols to support mobile group based applications in recent years. In this paper we address the performance issue of trust management protocol design for MANETs in two important areas: trust bias minimization and application performance maximization. By means of a novel model-based approach to model the ground truth status of mobile nodes in MANETs as the basis for design validation, we identify and validate the best trust protocol settings under which trust bias is minimized and application performance is maximized. We demonstrate the effectiveness of our approach with an integrated social and quality-of-service (QoS) trust protocol (called SQTrust) with which we identify the best trust aggregation setting under which trust bias is minimized despite the presence of malicious nodes performing slandering attacks. Furthermore, using a mission-oriented mobile group utilizing SQTrust, we identity the best trust formation protocol setting under which the application performance in terms of the system reliability of the mission-oriented mobile group is maximized. (C) 2014 Elsevier B.V. All rights reserved. C1 [Chen, Ing-Ray; Guo, Jia; Sao, Fenye] Virginia Tech, Dept Comp Sci, Falls Church, VA 22043 USA. [Cho, Jin-Hee] US Army Res Lab, Computat & Informat Sci Directorate, Adelphi, MD USA. RP Chen, IR (reprint author), Virginia Tech, Dept Comp Sci, 7054 Haycock Rd, Falls Church, VA 22043 USA. EM irchen@vt.edu; jiaguo@vt.edu; baofenye@vt.edu; jinhee.cho@us.army.mil FU Army Research Office [W911NF-12-1-0445] FX This work was supported in part by the Army Research Office under Grant W911NF-12-1-0445. NR 75 TC 9 Z9 9 U1 1 U2 18 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1570-8705 EI 1570-8713 J9 AD HOC NETW JI Ad Hoc Netw. PD AUG PY 2014 VL 19 BP 59 EP 74 DI 10.1016/j.adhoc.2014.02.005 PG 16 WC Computer Science, Information Systems; Telecommunications SC Computer Science; Telecommunications GA AJ4QF UT WOS:000337660200005 ER PT J AU Shubitidze, F Fernandez, JP Barrowes, BE Shamatava, I Bijamov, A O'Neill, K Karkashadze, D AF Shubitidze, Fridon Fernandez, Juan Pablo Barrowes, Benjamin E. Shamatava, Irma Bijamov, Alex O'Neill, Kevin Karkashadze, David TI The Orthonormalized Volume Magnetic Source Model for Discrimination of Unexploded Ordnance SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE Electromagnetic induction (EMI); inverse problems; Time-Domain Electromagnetic Multisensor Towed Array Detection System (TEMTADS) sensor; unexploded ordnance (UXO) ID ELECTROMAGNETIC INDUCTION SENSORS; UXO DISCRIMINATION; DIFFERENTIAL EVOLUTION; METALLIC OBJECT; EMI RESPONSE; CLASSIFICATION; IDENTIFICATION; POLARIZABILITIES; DIAGONALIZATION; ALGORITHM AB We introduce a fast and accurate numerical technique for the solution of electromagnetic induction sensing problems called the orthonormalized volume magnetic source model. The model assumes that the secondary magnetic field measured by a sensor originates from a set of magnetic dipole sources distributed over a volume that coincides with the interrogated area. The Green functions associated with the responding sources are turned into an orthonormal basis using a generalization of the Gram-Schmidt method, enabling one to determine the sources' strengths directly from measured data without having to invert large and potentially ill-conditioned matrices. The method treats multitarget cases naturally and robustly. Several examples are presented to illustrate the applicability of the method in the discrimination of unexploded ordnance (UXO). In particular, we analyze data taken by the Time-Domain Electromagnetic Multisensor Towed Array Detection System sensor array at a test stand and during a blind test administered at a UXO live site. The method is highly successful in distinguishing UXO from among other UXO and from accompanying clutter. C1 [Shubitidze, Fridon; Fernandez, Juan Pablo; Shamatava, Irma; Bijamov, Alex; O'Neill, Kevin] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. [Barrowes, Benjamin E.] US Army Corps Engn, Engn Res & Dev Ctr, Cold Regions Res & Engn Lab, Hanover, NH 03755 USA. [Karkashadze, David] Tbilisi State Univ, Dept Phys, Lab Appl Electrodynam, GE-0179 Tbilisi, Rep of Georgia. [Karkashadze, David] EMCoS, Electromagnet Consulting & Software Grp, GE-0160 Tbilisi, Rep of Georgia. RP Shubitidze, F (reprint author), Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. EM fridon.shubitidze@dartmouth.edu FU Strategic Environmental Research and Development Program [MR-1572, MR-1664]; Environmental Security Technology Certification Program [MR-201101]; Army Research Office (ARO) [55000EV] FX This work was supported in part by the Strategic Environmental Research and Development Program through Projects MR-1572 and MR-1664, in part by the Environmental Security Technology Certification Program through Project MR-201101, and in part by the Army Research Office (ARO) through Grant 55000EV. NR 61 TC 5 Z9 6 U1 0 U2 21 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0196-2892 EI 1558-0644 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD AUG PY 2014 VL 52 IS 8 BP 4658 EP 4670 DI 10.1109/TGRS.2013.2283346 PG 13 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA AC5ZC UT WOS:000332598500015 ER PT J AU Wang, ZW Nasrabadi, NM Huang, TS AF Wang, Zhaowen Nasrabadi, Nasser M. Huang, Thomas S. TI Spatial-Spectral Classification of Hyperspectral Images Using Discriminative Dictionary Designed by Learning Vector Quantization SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE Classification; dictionary learning; hyperspectral imagery (HSI); learning vector quantization (LVQ); sparse representation; spatial dependence ID SPARSE REPRESENTATION; K-SVD; ALGORITHM; RECOVERY; PROFILES AB In this paper, a novel discriminative dictionary learning method is proposed for sparse-representation-based classification (SRC) to label highly dimensional hyperspectral imagery (HSI). In SRC, a dictionary is conventionally constructed using all of the training pixels, which is not only inefficient due to the large size of typical HSI images but also ineffective in capturing class-discriminative information crucial for classification. We address the dictionary design problem with the inspiration from the learning vector quantization technique and propose a hinge loss function that is directly related to the classification task as the objective function for dictionary learning. The resulting online learning procedure systematically "pulls" and "pushes" dictionary atoms so that they become better adapted to distinguish between different classes. In addition, the spatial context for a test pixel within its local neighborhood is modeled using a Bayesian graph model and is incorporated with the sparse representation of a single test pixel in a unified probabilistic framework, which enables further refinement of our dictionary to capture the spatial class dependence that complements the spectral information. Experiments on different HSI images demonstrate that the dictionaries optimized using our method can achieve higher classification accuracy with substantially reduced dictionary size than using the whole training set. The proposed method also outperforms existing dictionary learning methods and attains the state-of-the-art results in both the spectral-only and spatial-spectral settings. C1 [Wang, Zhaowen; Huang, Thomas S.] Univ Illinois, Beckman Inst Adv Sci & Technol, Dept Elect & Comp Engn, Urbana, IL 61801 USA. [Nasrabadi, Nasser M.] US Army Res Lab, Adelphi, MD 20783 USA. RP Wang, ZW (reprint author), Univ Illinois, Beckman Inst Adv Sci & Technol, Dept Elect & Comp Engn, Urbana, IL 61801 USA. FU U.S. Army Research Laboratory; U.S. Army Research Office [W911NF-09-1-0383] FX This work was supported by the U.S. Army Research Laboratory and U.S. Army Research Office under Grant W911NF-09-1-0383. NR 42 TC 27 Z9 28 U1 1 U2 55 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0196-2892 EI 1558-0644 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD AUG PY 2014 VL 52 IS 8 BP 4808 EP 4822 DI 10.1109/TGRS.2013.2285049 PG 15 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA AC5ZC UT WOS:000332598500027 ER PT J AU Bijamov, A Fernandez, JP Barrowes, BE Shamatava, I O'Neill, K Shubitidze, F AF Bijamov, Alex Fernandez, Juan Pablo Barrowes, Benjamin E. Shamatava, Irma O'Neill, Kevin Shubitidze, Fridon TI Camp Butner Live-Site UXO Classification Using Hierarchical Clustering and Gaussian Mixture Modeling SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE Agglomerative hierarchical clustering; Camp Butner; classification; electromagnetic induction (EMI); ESTCP; inverse problems; ONVMS; semisupervised learning; unexploded ordnance (UXO) ID UNEXPLODED ORDNANCE DETECTION; MAGNETIC CHARGE MODEL; DIFFERENTIAL EVOLUTION; METALLIC OBJECT; DISCRIMINATION; ALGORITHM; SELECTION; TARGETS AB We demonstrate in detail a semisupervised scheme to classify unexploded ordnance (UXO) by using as an example the data collected with a time-domain electromagnetic towed array detection system during a live-site blind test conducted at the former Camp Butner in North Carolina, USA. The model that we use to characterize targets and generate discrimination features relies on a solution of the inverse UXO problem using the orthonormalized volume magnetic source model. Unlike other classification techniques, which often rely on library matching or expert knowledge, our combined clustering/Gaussian-mixture-model approach first uses the inherent properties of the data in feature space to build a custom training list that is then used to score all unknown targets by assigning them a likelihood of being UXO. The ground truth for the most likely candidates is then requested and used to correct the model parameters and reassign the scores. The process is repeated several times until the desired statistical margin is reached, at which point a final dig is produced. Our method could decrease intervention by human experts and, as the results of the blind test show, identify all targets of interest correctly while minimizing false-alarm counts. C1 [Bijamov, Alex; Fernandez, Juan Pablo; Barrowes, Benjamin E.; Shamatava, Irma; O'Neill, Kevin; Shubitidze, Fridon] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. [Barrowes, Benjamin E.] US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Shamatava, Irma] Sky Res Inc, Hanover, NH 03755 USA. RP Bijamov, A (reprint author), Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. EM fridon.shubitidze@dartmouth.edu FU Strategic Environmental Research and Development Program [MR-1572] FX This work was supported in part by the Strategic Environmental Research and Development Program under Project MR-1572 NR 60 TC 3 Z9 4 U1 0 U2 29 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0196-2892 EI 1558-0644 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD AUG PY 2014 VL 52 IS 8 BP 5218 EP 5229 DI 10.1109/TGRS.2013.2287510 PG 12 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA AC5ZC UT WOS:000332598500059 ER PT J AU Newburgh, GA Dubinskii, M AF Newburgh, G. A. Dubinskii, M. TI Compact, high gain, hetero-composite Nd:YVO4/SiC thin disk amplifier with advanced thermal management SO ELECTRONICS LETTERS LA English DT Article ID EMISSION CROSS-SECTION; LASER; ND/YVO4; YVO4 AB A thermally advanced, Nd:YVO4 amplifier at 1064 nm based on an 800 mu m-thick Nd:YVO4 gain layer bonded to a silicon carbide (SiC) prism is demonstrated. The amplifier was tested in the 'master oscillator-power amplifier' configuration, where both the seed source and the amplifier were operated in a quasi-continuous-wave regime. The hetero-composite Nd:YVO4/SiC gain element pumped by an 808 nm laser diode bar stack amplified the seed power in a range of 1-55 W with a gain of 4-2.6, respectively. The temperature profile of the gain element measured by a thermal camera indicated the maximum observed temperature excursion at pump saturation intensity to be only 27 degrees C. C1 [Newburgh, G. A.; Dubinskii, M.] US Army Res Lab, Adelphi, MD 20783 USA. RP Newburgh, GA (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM george.a.newburgh.civ@mail.mil NR 8 TC 0 Z9 0 U1 2 U2 6 PU INST ENGINEERING TECHNOLOGY-IET PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND SN 0013-5194 EI 1350-911X J9 ELECTRON LETT JI Electron. Lett. PD JUL 31 PY 2014 VL 50 IS 16 BP 1152 EP + DI 10.1049/el.2014.1900 PG 2 WC Engineering, Electrical & Electronic SC Engineering GA AO0TB UT WOS:000341023800027 ER PT J AU Saunders, DL Vanachayangkul, P Lon, C AF Saunders, David L. Vanachayangkul, Pattaraporn Lon, Chanthap CA US Army Mil Malaria Res Program Ctr Parasitology Entomology Royal Cambodian Armed Forces TI Dihydroartemisinin-Piperaquine Failure in Cambodia SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter ID FALCIPARUM-MALARIA; PLASMODIUM-FALCIPARUM; EFFICACY C1 [Saunders, David L.; Vanachayangkul, Pattaraporn] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Lon, Chanthap] Armed Forces Res Inst Med Sci, Phnom Penh, Cambodia. RP Saunders, DL (reprint author), Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. EM david.saunders@afrims.org NR 5 TC 57 Z9 57 U1 0 U2 2 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD JUL 31 PY 2014 VL 371 IS 5 BP 484 EP 485 DI 10.1056/NEJMc1403007 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA AM0SK UT WOS:000339556900027 PM 25075853 ER PT J AU Piyawit, W Xu, WZ Mathaudhu, SN Freudenberger, J Rigsbee, JM Zhu, YT AF Piyawit, W. Xu, W. Z. Mathaudhu, S. N. Freudenberger, J. Rigsbee, J. M. Zhu, Y. T. TI Nucleation and growth mechanism of Ag precipitates in a CuAgZr alloy SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Precipitation; Ledge; Interfaces; Copper alloys; Precipitate alignment ID ELECTRICAL-CONDUCTIVITY; STACKING FAULTS; HIGH-STRENGTH; CONTACT WIRE; BEHAVIOR; MICROSTRUCTURE; MICROCOMPOSITES; KINETICS; STEELS; STRIP AB CuAgZr alloy is a variant of the CuAg alloy that is developed for high strength and high conductivity applications. Its strengthening is accomplished mainly by the precipitation of Ag precipitates, which tend to align on {111} planes in the Cu matrix. This alignment has been reported to be caused by stacking faults on {111} planes. Contrary to these reports, this research presents evidence for Ag precipitates formation on {111} planes due to the minimization of elastic energy. The Ag precipitates were formed by clustering of Ag atoms while maintaining the fcc crystal structure of the matrix. They have faceted {111} interfaces with the matrix. The thickening of precipitates appears to be by the ledge growth mechanism, which is resulted in by misfit dislocation networks on the interface. (C) 2014 Elsevier B.V. All rights reserved. C1 [Piyawit, W.; Xu, W. Z.; Mathaudhu, S. N.; Rigsbee, J. M.; Zhu, Y. T.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Mathaudhu, S. N.] US Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. [Freudenberger, J.] IFW Dresden, Inst Metall Mat, D-01171 Dresden, Germany. [Freudenberger, J.] Tech Univ Bergakad Freiberg, Inst Mat Sci, D-09959 Freiberg, Germany. RP Zhu, YT (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. EM ytzhu@ncsu.edu RI Zhu, Yuntian/B-3021-2008; Mathaudhu, Suveen/B-4192-2009; OI Zhu, Yuntian/0000-0002-5961-7422; Freudenberger, Jens/0000-0002-3432-886X FU U.S. Army Research Office [W011 NF-12-1-0009]; Royal Thai Government scholarship FX The authors would like to thank Dr. V.S. Sarma for his contributions. This work is supported by the U.S. Army Research Office under Grant no. W011 NF-12-1-0009. One of the authors (Piyawit) acknowledges the Royal Thai Government scholarship for the financial support. NR 29 TC 2 Z9 3 U1 3 U2 24 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 EI 1873-4936 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD JUL 29 PY 2014 VL 610 BP 85 EP 90 DI 10.1016/j.msea.2014.05.023 PG 6 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA AL9JQ UT WOS:000339457800013 ER PT J AU Rao, SS Lee, YF Prater, JT Smirnov, AI Narayan, J AF Rao, S. S. Lee, Y. F. Prater, J. T. Smirnov, A. I. Narayan, J. TI Laser annealing induced ferromagnetism in SrTiO3 single crystal SO APPLIED PHYSICS LETTERS LA English DT Article ID INDUCED MAGNETISM; INTERFACE AB The appearance of ferromagnetic order up to 400K upon KrF (248 nm) laser irradiation is reported in un-doped SrTiO3 (STO) single crystal. The high resolution x-ray photo emission spectroscopy (XPS) measurements reveal a strong shift of Sr-, Ti-, and O-related peaks. X-ray diffraction of laser annealed STO does not reveal a signature of either secondary magnetic or amorphous phases. 300K X-band (similar to 9.543 GHz) angle-dependent electron paramagnetic resonance (EPR) measurements showed no evidence of additional magnetic peaks upon laser irradiation. XPS and EPR data did not provide a strong evidence of Ti3+ formation upon laser annealing. No differences in the visible 300K Raman spectra of pristine and laser annealed STO are noticed. Interestingly, the magnetic moment is decreased by almost 10-fold upon oxygen annealing of laser annealed STO, inferring that oxygen vacancies play an important role in establishing the observed ferromagnetism. (c) 2014 AIP Publishing LLC. C1 [Rao, S. S.; Prater, J. T.] Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. [Rao, S. S.; Lee, Y. F.; Prater, J. T.; Narayan, J.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Smirnov, A. I.] N Carolina State Univ, Dept Chem, Raleigh, NC 27695 USA. RP Rao, SS (reprint author), Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. EM ssingam@ncsu.edu RI Smirnov, Alex/Q-9818-2016 OI Smirnov, Alex/0000-0002-0037-2555 FU National Academy of Science (NAS), USA; State of North Carolina; National Science Foundation; Army Research Office [W911NF-04-D-0003] FX S.S.R. acknowledges National Academy of Science (NAS), USA for awarding the NRC postdoctoral research associate fellowship. Also, the authors acknowledge the use of the Analytical Instrumentation Facility (AIF) at North Carolina State University, which is supported by the State of North Carolina and the National Science Foundation. The authors are pleased to acknowledge the support of the Army Research Office under Grant W911NF-04-D-0003. NR 20 TC 7 Z9 7 U1 6 U2 84 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUL 28 PY 2014 VL 105 IS 4 AR 042403 DI 10.1063/1.4891184 PG 4 WC Physics, Applied SC Physics GA AO2LB UT WOS:000341152600049 ER PT J AU Kamau, E Alemayehu, S Feghali, KC Komisar, J Regules, J Cowden, J Ockenhouse, CF AF Kamau, Edwin Alemayehu, Saba Feghali, Karla C. Komisar, Jack Regules, Jason Cowden, Jessica Ockenhouse, Christian F. TI Measurement of parasitological data by quantitative real-time PCR from controlled human malaria infection trials at the Walter Reed Army Institute of Research SO MALARIA JOURNAL LA English DT Article ID POLYMERASE-CHAIN-REACTION; TO-BLOOD INOCULA; PLASMODIUM-FALCIPARUM; GROWTH-RATES; IN-VIVO; PARASITEMIA; VOLUNTEERS; CHALLENGE; VACCINES AB Background: The use of quantitative real-time PCR (qPCR) has allowed for precise quantification of parasites in the prepatent period and greatly improved the reproducibility and statistical power of controlled human malaria infection (CHMI) trials. Parasitological data presented here are from non-immunized, control-challenged subjects who participated in two CHMI trials conducted at the Walter Reed Army Institute of Research (WRAIR). Methods: Standardized sporozoite challenge was achieved through the bite of five Anopheles stephensi mosquitoes infected with the 3D7clone of the NF54 strain of Plasmodium falciparum. Blood smears were scored positive when two unambiguous parasites were found. Analysis of parasitological PCR data was performed on log-transformed data using an independent sample t-test when comparing the two studies. The multiplication rate of blood-stage parasites was estimated using the linear model. Results: On average, parasites were detected 4.91 days (95% CI = 4.190 to 5.627) before smears. The earliest parasites were detected within 120 hours (5.01 days) after challenge. Parasite densities showed consistent cyclic patterns of blood-stage parasite growth in all volunteers. The parasite multiplication rates for both studies was 8.18 (95% CI = 6.162 to 10.20). Data showed that at low parasite densities, a combination of sequestration and stochastic effects of low copy number DNA may impact qPCR detection and the parasite detection limit. Conclusion: Smear positive is an endpoint which antimalarial rescue is imperative whereas early detection of parasitological data by qPCR can allow for better anticipation of the endpoint. This would allow for early treatment to reduce clinical illness and risk for study participants. To use qPCR as the primary endpoint in CHMI trials, an algorithm of two positives by qPCR where one of the positives must have parasite density of at least 2 parasites/mu L is proposed. C1 [Kamau, Edwin; Alemayehu, Saba; Feghali, Karla C.; Komisar, Jack; Regules, Jason; Cowden, Jessica; Ockenhouse, Christian F.] Walter Reed Army Inst Res, Malaria Vaccine Branch, Mil Malaria Res Program, Silver Spring, MD 20910 USA. RP Kamau, E (reprint author), Walter Reed Army Inst Res, Malaria Vaccine Branch, Mil Malaria Res Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM edwin.kamau@us.army.mil NR 20 TC 3 Z9 3 U1 2 U2 7 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD JUL 28 PY 2014 VL 13 AR 288 DI 10.1186/1475-2875-13-288 PG 8 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AN5MH UT WOS:000340634900001 PM 25066459 ER PT J AU Li, QG Remich, S Miller, SR Ogutu, B Otieno, W Melendez, V Teja-Isavadharm, P Weina, PJ Hickman, MR Smith, B Polhemus, M AF Li, Qigui Remich, Shon Miller, Scott R. Ogutu, Bernhards Otieno, Walter Melendez, Victor Teja-Isavadharm, Paktiya Weina, Peter J. Hickman, Mark R. Smith, Bryan Polhemus, Mark TI Pharmacokinetic evaluation of intravenous artesunate in adults with uncomplicated falciparum malaria in Kenya: a phase II study SO MALARIA JOURNAL LA English DT Article DE Artesunate; Dihydroartemisinin; Pharmacokinetics; Intravenous; Uncomplicated falciparum malaria; Clinical trial ID PLASMODIUM-FALCIPARUM; HEALTHY-VOLUNTEERS; CLINICAL EFFICACY; 8 MG/KG; BIOAVAILABILITY; DIHYDROARTEMISININ; CHILDREN; QUININE; NEUROTOXICITY; ARTEETHER AB Background: Alternatives to treatment for malaria treatment of travellers are needed in the USA and in Europe for travellers who return with severe malaria infections. The objective of this study is to show the pharmacokinetic (PK) profile of intravenous artesunate (AS), which was manufactured under good manufacturing practice (GMP) conditions, in adults with uncomplicated falciparum malaria in Kenya. Methods: The PK parameters of intravenous AS manufactured under current cGMP were evaluated after a single dose of drug at 2.4 mg/kg infused over 2 min in 28 adults with uncomplicated Plasmodium falciparum malaria. Plasma concentrations of AS and dihydroartemisinin (DHA) were measured using a validated liquid chromatography-mass spectrometry (LC-MS/MS) methodology. Pharmacokinetic data were analysed with a compartmental analysis for AS and DHA. Results: The results suggest there were no drug-related adverse events in any of the patients. After intravenous infusion, the concentration of the parent drug rapidly declined, and the AS was converted to DHA. AS and DHA showed mean elimination half-lives of 0.17 hours and 1.30 hours, respectively. The high mean peak concentration (C-max) of AS was shown to be 28,558 ng/mL while the C-max of DHA was determined to be 2,932 ng/mL. Significant variability was noted in the PK profiles of the 28 patients tested. For example, C-max values of AS were calculated to range from 3,362 to 55,873 ng/mL, and the C-max value of DHA was noted to vary from 1,493 to 5,569 ng/mL. The mean area under the curve (AUC) of AS was shown to be approximately half that of DHA (1,878 ng.h/mL vs 3,543 ng.h/mL). The DHA/AS ratio observed was 1.94 during the one-day single treatment, and the AUC and half-life measured for DHA were significantly larger and longer than for AS. Conclusions: Intravenous AS can provide much higher peak concentrations of AS when compared to concentrations achieved with oral therapy; this may be crucial for the rapid elimination of parasites in patients with severe malaria. Given the much longer half-life of DHA compared to the short half-life of AS, DHA also plays a significant role in treatment of severe malaria. C1 [Li, Qigui; Remich, Shon; Miller, Scott R.; Melendez, Victor; Weina, Peter J.; Hickman, Mark R.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Ogutu, Bernhards; Otieno, Walter] US Army Med Res Unit, Kisumu Res Stn, Kisumu, Kenya. [Teja-Isavadharm, Paktiya; Smith, Bryan] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. RP Li, QG (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM qigui.li.civ@mail.mil FU US Army Research and Materiel Command FX This study was supported by the US Army Research and Materiel Command. Material has been reviewed by the Walter Reed Army Institute of Research. There is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official, or as reflecting the views of the Department of the Army or the Department of Defense. NR 32 TC 1 Z9 1 U1 0 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD JUL 22 PY 2014 VL 13 AR 281 DI 10.1186/1475-2875-13-281 PG 9 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AN5LR UT WOS:000340633200001 PM 25047305 ER PT J AU Khmaladze, E Birdsell, DN Naumann, AA Hochhalter, CB Seymour, ML Nottingham, R Beckstrom-Sternberg, SM Beckstrom-Sternberg, J Nikolich, MP Chanturia, G Zhgenti, E Zakalashvili, M Malania, L Babuadze, G Tsertsvadze, N Abazashvili, N Kekelidze, M Tsanava, S Imnadze, P Ganz, HH Getz, WM Pearson, O Gajer, P Eppinger, M Ravel, J Wagner, DM Okinaka, RT Schupp, JM Keim, P Pearson, T AF Khmaladze, Ekaterine Birdsell, Dawn N. Naumann, Amber A. Hochhalter, Christian B. Seymour, Meagan L. Nottingham, Roxanne Beckstrom-Sternberg, Stephen M. Beckstrom-Sternberg, James Nikolich, Mikeljon P. Chanturia, Gvantsa Zhgenti, Ekaterine Zakalashvili, Mariam Malania, Lile Babuadze, Giorgi Tsertsvadze, Nikoloz Abazashvili, Natalia Kekelidze, Merab Tsanava, Shota Imnadze, Paata Ganz, Holly H. Getz, Wayne M. Pearson, Ofori Gajer, Pawel Eppinger, Mark Ravel, Jacques Wagner, David M. Okinaka, Richard T. Schupp, James M. Keim, Paul Pearson, Talima TI Phylogeography of Bacillus anthracis in the Country of Georgia Shows Evidence of Population Structuring and Is Dissimilar to Other Regional Genotypes SO PLOS ONE LA English DT Article ID STRAINS; DIVERSITY AB Sequence analyses and subtyping of Bacillus anthracis strains from Georgia reveal a single distinct lineage (Aust94) that is ecologically established. Phylogeographic analysis and comparisons to a global collection reveals a clade that is mostly restricted to Georgia. Within this clade, many groups are found around the country, however at least one subclade is only found in the eastern part. This pattern suggests that dispersal into and out of Georgia has been rare and despite historical dispersion within the country, for at least for one lineage, current spread is limited. C1 [Khmaladze, Ekaterine; Chanturia, Gvantsa; Zhgenti, Ekaterine; Zakalashvili, Mariam; Malania, Lile; Babuadze, Giorgi; Tsertsvadze, Nikoloz; Abazashvili, Natalia; Kekelidze, Merab; Tsanava, Shota; Imnadze, Paata] Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia. [Birdsell, Dawn N.; Naumann, Amber A.; Hochhalter, Christian B.; Seymour, Meagan L.; Nottingham, Roxanne; Beckstrom-Sternberg, Stephen M.; Beckstrom-Sternberg, James; Wagner, David M.; Okinaka, Richard T.; Schupp, James M.; Keim, Paul; Pearson, Talima] Univ Arizona, Ctr Microbial Genet & Genom, Flagstaff, AZ 86011 USA. [Nikolich, Mikeljon P.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Ganz, Holly H.; Getz, Wayne M.] Univ Calif Berkeley, Dept Environm Sci Policy & Management, Berkeley, CA 94720 USA. [Pearson, Ofori] US Geol Survey, Denver Fed Ctr, Denver, CO 80225 USA. [Gajer, Pawel; Eppinger, Mark; Ravel, Jacques] Inst Genome Sci, Baltimore, MD USA. [Eppinger, Mark] Univ Texas San Antonio, San Antonio, TX USA. [Khmaladze, Ekaterine; Tsanava, Shota; Imnadze, Paata] Ivane Javakhishvili Tbilisi State Univ, Tbilisi, Rep of Georgia. RP Pearson, T (reprint author), Univ Arizona, Ctr Microbial Genet & Genom, Flagstaff, AZ 86011 USA. EM Talima.Pearson@nau.edu OI Getz, Wayne/0000-0001-8784-9354; Ravel, Jacques/0000-0002-0851-2233 FU U.S. Department of Homeland Security S&T CB Division Bioforensics RD Program [HSHQDC-10-C-00139]; Department of Defense's Defense Threat Reduction Agency [CBCALL12-DIAGB1-2-0194]; National Institutes of Health [GM083863] FX This work was funded by the U.S. Department of Homeland Security S&T CB Division Bioforensics R&D Program (HSHQDC-10-C-00139) and by the Department of Defense's Defense Threat Reduction Agency (CBCALL12-DIAGB1-2-0194). Support for collecting the samples in Namibia was provided by National Institutes of Health GM083863 grant to Wayne M. Getz. The use of products/names does not constitute endorsement by the United States DHS. The findings and opinions expressed herein belong to the authors and do not necessarily reflect the official views of the Walter Reed Army Institute of Research, the U.S. Army or the Department of Defense. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 15 TC 8 Z9 8 U1 0 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUL 21 PY 2014 VL 9 IS 7 AR e102651 DI 10.1371/journal.pone.0102651 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AM0SW UT WOS:000339558100057 PM 25047912 ER PT J AU Tian, LM Tadepalli, S Farrell, ME Liu, KK Gandra, N Pellegrino, PM Singamaneni, S AF Tian, Limei Tadepalli, Sirimuvva Farrell, Mikella E. Liu, Keng-Ku Gandra, Naveen Pellegrino, Paul M. Singamaneni, Srikanth TI Multiplexed charge-selective surface enhanced Raman scattering based on plasmonic calligraphy SO JOURNAL OF MATERIALS CHEMISTRY C LA English DT Article ID SINGLE-MOLECULE; GOLD NANORODS; EXCITATION SPECTROSCOPY; CHEMICAL-DETECTION; SERS; PAPER; NANOPARTICLES; SILVER; NANOSTRUCTURES; DIAGNOSTICS AB Multiplexed surface enhanced Raman scattering (SERS) substrates, which enable chemically selective detection of two or more target analytes from a complex chemical mixture, are highly attractive for chemical detection in real-world settings. We introduce a new approach called plasmonic calligraphy that involves the formation of chemically selective test domains on paper substrates using functionalized plasmonic nanostructures as ink in a regular ballpoint pen. We demonstrate selective detection of positively and negatively charged analytes (rhodamine 6G and methyl orange) from complex chemical mixtures using polyelectrolyte-coated gold nanorods as SERS medium. The approach demonstrated here obviates the need for complex patterning techniques such as photolithography to create isolated test domains on paper substrates for multiplexed chemical detection. Plasmonic calligraphy can be easily extended to other shape-controlled nanostructures with different surface functionalities and potentially automated by implementation with a robotic arm. C1 [Tian, Limei; Tadepalli, Sirimuvva; Liu, Keng-Ku; Gandra, Naveen; Singamaneni, Srikanth] Washington Univ, Inst Mat Sci & Engn, Dept Mech Engn & Mat Sci, St Louis, MO 63130 USA. [Farrell, Mikella E.; Pellegrino, Paul M.] US Army, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. RP Singamaneni, S (reprint author), Washington Univ, Inst Mat Sci & Engn, Dept Mech Engn & Mat Sci, St Louis, MO 63130 USA. EM singamaneni@wustl.edu OI Tadepalli, Sirimuvva/0000-0001-9658-9988 FU Army Research Office (ARO) [W911NF-11-2-0091]; Army Research Lab (ARL) [W911NF-11-2-0091]; National Science Foundation CAREER award FX This work was supported by Army Research Office (ARO) and Army Research Lab (ARL) under Contract no. W911NF-11-2-0091 and National Science Foundation CAREER award. We would like thank Nano Research Facility (NRF), a member of the National Nanotechnology Infrastructure Network (NNIN), for providing access to electron microscopy facilities. NR 49 TC 10 Z9 10 U1 0 U2 34 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2050-7526 EI 2050-7534 J9 J MATER CHEM C JI J. Mater. Chem. C PD JUL 21 PY 2014 VL 2 IS 27 BP 5438 EP 5446 DI 10.1039/c4tc00768a PG 9 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA AK7IK UT WOS:000338601800025 ER PT J AU Soller, B Srikiatkachorn, A Zou, FM Rothman, AL Yoon, IK Gibbons, RV Kalayanarooj, S Thomas, SJ Green, S AF Soller, Babs Srikiatkachorn, Anon Zou, Fengmei Rothman, Alan L. Yoon, In-Kyu Gibbons, Robert V. Kalayanarooj, Siripen Thomas, Stephen J. Green, Sharone TI Preliminary evaluation of near infrared spectroscopy as a method to detect plasma leakage in children with dengue hemorrhagic fever SO BMC INFECTIOUS DISEASES LA English DT Article ID MUSCLE OXYGEN-SATURATION; NONINVASIVE MEASUREMENT; CENTRAL HYPOVOLEMIA AB Background: Dengue viral infections are prevalent in the tropical and sub-tropical regions of the world, resulting in substantial morbidity and mortality. Clinical manifestations range from a self-limited fever to a potential life-threatening plasma leakage syndrome (dengue hemorrhagic fever). The objective of this study was to assess the utility of near infrared spectroscopy (NIRS) measurements of muscle oxygen saturation (SmO2) as a possible continuous measure to detect plasma leakage in children with dengue. Methods: Children ages 6 months to 15 years of age admitted with suspected dengue were enrolled from the dengue ward at Queen Sirikit National Institute for Child Health. Children were monitored daily until discharge. NIRS data were collected continuously using a prototype CareGuide Oximeter 1100 with sensors placed on the deltoid or thigh. Daily ultrasound of the chest and a right lateral decubitus chest x-ray the day after defervescence were performed to detect and quantitate plasma leakage in the pleural cavity. Results: NIRS data were obtained from 19 children with laboratory-confirmed dengue. Average minimum SmO2 decreased for all subjects prior to defervescence. Average minimum SmO2 subsequently increased in children with no ultrasound evidence of pleural effusion but remained low in children with pleural effusion following defervescence. Average minimum SmO2 was inversely correlated with pleural space fluid volume. ROC analysis revealed a cut-off value for SmO2 which yielded high specificity and sensitivity. Conclusions: SmO2 measured using NIRS may be a useful guide for real-time and non-invasive identification of plasma leakage in children with dengue. Further investigation of the utility of NIRS measurements for prediction and management of severe dengue syndromes is warranted. C1 [Soller, Babs; Zou, Fengmei] Reflectance Med Inc, Westborough, MA 01581 USA. [Soller, Babs] Univ Massachusetts, Sch Med, Dept Anesthesiol, Worcester, MA 01655 USA. [Srikiatkachorn, Anon; Green, Sharone] Univ Massachusetts, Sch Med, Div Infect Dis & Immunol, Worcester, MA 01655 USA. [Srikiatkachorn, Anon; Yoon, In-Kyu; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Rothman, Alan L.] Univ Rhode Isl, Inst Immunol & Informat, Providence, RI 02903 USA. [Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok 10400, Thailand. [Thomas, Stephen J.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD 20910 USA. RP Soller, B (reprint author), Reflectance Med Inc, 116 Flanders Rd,Suite 1000, Westborough, MA 01581 USA. EM babs.soller@reflectancemedical.com FU Department of Virology, Armed Forces Research Institute of Medical Sciences; National Institutes of Health [NIH-P01AI34533]; Military Infectious Disease Research Program; Telemedicine & Advanced Technology Research Center FX The authors thank the staff of the Department of Virology, Armed Forces Research Institute of Medical Sciences for sample collection, diagnostic testing, and research support; Dr. Suchitra Nimmannitya for reviewing the clinical diagnoses; doctors and nurses of the Queen Sirikit National Institute of Child Health for patient care; and the subjects and families who participated in this study. This work was supported by National Institutes of Health Grant NIH-P01AI34533 (AS ALR SG SK), the Military Infectious Disease Research Program (RVG IY SJT SK) and the Telemedicine & Advanced Technology Research Center (BS FZ). NR 16 TC 0 Z9 0 U1 1 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD JUL 17 PY 2014 VL 14 AR 396 DI 10.1186/1471-2334-14-396 PG 6 WC Infectious Diseases SC Infectious Diseases GA AM0HI UT WOS:000339524700001 PM 25033831 ER PT J AU Schmaljohn, CS Spik, KW Hooper, JW AF Schmaljohn, Connie S. Spik, Kristin W. Hooper, Jay W. TI DNA vaccines for HFRS: Laboratory and clinical studies SO VIRUS RESEARCH LA English DT Article DE Hemorrhagic fever with renal syndrome; Hantaviruses; DNA vaccine; Electroporation; Phase 1 clinical study ID HANTAAN-VIRUS; PUUMALA VIRUS; ENCEPHALITIS-VIRUS; MONOCLONAL-ANTIBODY; HEMORRHAGIC-FEVER; NONHUMAN-PRIMATES; RENAL SYNDROME; M-GENOME; IMMUNOGENICITY; VACCINATION AB DNA vaccines can be constructed to produce specific immunogens while avoiding the risks associated with propagating infectious viruses. Plasmid DNA vaccines have well established manufacturing procedures and are safe in that they are replication defective, cannot revert to virulence and cannot be transmitted from person-to-person or into the environment. In addition, DNA vaccines can be combined to form multivalent formulations and can be delivered by a variety of methods. Because of these numerous advantages, we have developed DNA vaccines expressing the envelope glycoprotein genes of hantaviruses causing hemorrhagic fever with renal syndrome (HFRS). We have demonstrated that these DNA vaccines elicit neutralizing antibodies in multiple laboratory animal species when delivered to skin or muscle tissues. Moreover, these vaccines delivered as active vaccines or passive vaccines (e.g., transfer of sera from vaccinated rabbits or nonhuman primates), protected hamsters from infection with HFRS-causing hantaviruses. Early clinical studies of HFRS vaccines expressing Hantaan virus or Puumala virus genes have been completed and show promise for further development. Despite these advantages, issues relating to inconsistent immunogenicity and immune interference remain to be addressed. Published by Elsevier B.V. C1 [Schmaljohn, Connie S.; Spik, Kristin W.; Hooper, Jay W.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Schmaljohn, CS (reprint author), US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM connie.schmaljohn@us.army.mil OI Hooper, Jay/0000-0002-4475-0415 NR 21 TC 7 Z9 7 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-1702 EI 1872-7492 J9 VIRUS RES JI Virus Res. PD JUL 17 PY 2014 VL 187 BP 91 EP 96 DI 10.1016/j.virusres.2013.12.020 PG 6 WC Virology SC Virology GA AL6CO UT WOS:000339220000015 PM 24370868 ER PT J AU Memisevic, V Kumar, K Cheng, L Zavaljevski, N DeShazer, D Wallqvist, A Reifman, J AF Memisevic, Vesna Kumar, Kamal Cheng, Li Zavaljevski, Nela DeShazer, David Wallqvist, Anders Reifman, Jaques TI DBSecSys: a database of Burkholderia mallei secretion systems SO BMC BIOINFORMATICS LA English DT Article DE Bacterial secretion system; Virulence factors; Pathogenic mechanisms of action; Host-pathogen interactions; Burkholderia mallei ID VIRULENCE FACTORS; BIOTECHNOLOGY-INFORMATION; BIOINFORMATICS RESOURCE; PROTEIN INTERACTIONS; NATIONAL-CENTER; GENE ONTOLOGY; VI SECRETION; PSEUDOMALLEI; UPDATE; MELIOIDOSIS AB Background: Bacterial pathogenicity represents a major public health concern worldwide. Secretion systems are a key component of bacterial pathogenicity, as they provide the means for bacterial proteins to penetrate host-cell membranes and insert themselves directly into the host cells' cytosol. Burkholderia mallei is a Gram-negative bacterium that uses multiple secretion systems during its host infection life cycle. To date, the identities of secretion system proteins for B. mallei are not well known, and their pathogenic mechanisms of action and host factors are largely uncharacterized. Description: We present the Database of Burkholderia mallei Secretion Systems (DBSecSys), a compilation of manually curated and computationally predicted bacterial secretion system proteins and their host factors. Currently, DBSecSys contains comprehensive experimentally and computationally derived information about B. mallei strain ATCC 23344. The database includes 143 B. mallei proteins associated with five secretion systems, their 1,635 human and murine interacting targets, and the corresponding 2,400 host-B. mallei interactions. The database also includes information about 10 pathogenic mechanisms of action for B. mallei secretion system proteins inferred from the available literature. Additionally, DBSecSys provides details about 42 virulence attenuation experiments for 27 B. mallei secretion system proteins. Users interact with DBSecSys through a Web interface that allows for data browsing, querying, visualizing, and downloading. Conclusions: DBSecSys provides a comprehensive, systematically organized resource of experimental and computational data associated with B. mallei secretion systems. It provides the unique ability to study secretion systems not only through characterization of their corresponding pathogen proteins, but also through characterization of their host-interacting partners. C1 [Memisevic, Vesna; Kumar, Kamal; Cheng, Li; Zavaljevski, Nela; Wallqvist, Anders; Reifman, Jaques] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, US Dept Def, Biotechnol High Performance Comp Software Applica, Ft Detrick, MD 21702 USA. [DeShazer, David] US Army Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. RP Reifman, J (reprint author), US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, US Dept Def, Biotechnol High Performance Comp Software Applica, Ft Detrick, MD 21702 USA. EM jaques.reifman.civ@mail.mil OI Kumar, Kamal/0000-0002-9470-6682; wallqvist, anders/0000-0002-9775-7469 FU Defense Threat Reduction Agency [CBS.MEDBIO.02.10.BH.021]; U.S. Army Medical Research and Materiel Command (Ft. Detrick, MD), U.S. Army's Network Science Initiative FX This work was supported by the Defense Threat Reduction Agency (project CBS.MEDBIO.02.10.BH.021) and by the U.S. Army Medical Research and Materiel Command (Ft. Detrick, MD) as part of the U.S. Army's Network Science Initiative. NR 44 TC 6 Z9 6 U1 0 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2105 J9 BMC BIOINFORMATICS JI BMC Bioinformatics PD JUL 16 PY 2014 VL 15 AR 244 DI 10.1186/1471-2105-15-244 PG 9 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Mathematical & Computational Biology GA AL8RJ UT WOS:000339406400001 PM 25030112 ER PT J AU Gil, S Kott, A Barabasi, AL AF Gil, Santiago Kott, Alexander Barabasi, Albert-Laszlo TI A genetic epidemiology approach to cyber-security SO SCIENTIFIC REPORTS LA English DT Article ID ATTACK; ASSOCIATION; CHALLENGES; NETWORKS AB While much attention has been paid to the vulnerability of computer networks to node and link failure, there is limited systematic understanding of the factors that determine the likelihood that a node (computer) is compromised. We therefore collect threat log data in a university network to study the patterns of threat activity for individual hosts. We relate this information to the properties of each host as observed through network-wide scans, establishing associations between the network services a host is running and the kinds of threats to which it is susceptible. We propose a methodology to associate services to threats inspired by the tools used in genetics to identify statistical associations between mutations and diseases. The proposed approach allows us to determine probabilities of infection directly from observation, offering an automated high-throughput strategy to develop comprehensive metrics for cyber-security. C1 [Gil, Santiago; Barabasi, Albert-Laszlo] Northeastern Univ, Ctr Complex Network Res, Boston, MA 02130 USA. [Gil, Santiago] Seed Sci, New York, NY 10013 USA. [Kott, Alexander] Army Res Lab, Network Sci Div, Adelphi, MD 20783 USA. [Barabasi, Albert-Laszlo] Dana Farber Canc Inst, Ctr Canc Syst Biol, Boston, MA 02115 USA. [Barabasi, Albert-Laszlo] Harvard Univ, Brigham & Womens Hosp, Dept Med, Sch Med, Boston, MA 02115 USA. RP Gil, S (reprint author), Northeastern Univ, Ctr Complex Network Res, Boston, MA 02130 USA. EM sg.ccnr@gmail.com FU Army Research Lab (ARL) under the project "Metrics for monitoring robustness and controllability'' [W911NF-11-2-0086] FX The authors would like to thank Dr. Hasan Cam, Dr. Engin Kirda and David Blank-Edelman for valuable discussions and fruitful advice. Special thanks to Rajiv Shridhar, Ray Lisiecki and Joseph De Nicolo for their essential support with the data collection. This research was supported by the Army Research Lab (ARL) through Grant W911NF-11-2-0086, under the project "Metrics for monitoring robustness and controllability''. NR 31 TC 4 Z9 4 U1 0 U2 18 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD JUL 16 PY 2014 VL 4 AR 5659 DI 10.1038/srep05659 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AL2YJ UT WOS:000338991300001 PM 25028059 ER PT J AU Redding, B Pan, YL Wang, CJ Cao, H AF Redding, Brandon Pan, Yong-Le Wang, Chuji Cao, Hui TI Polarization-resolved near-backscattering of airborne aggregates composed of different primary particles SO OPTICS LETTERS LA English DT Article ID LIGHT-SCATTERING; NEGATIVE POLARIZATION; SPECTRA; SIZE AB We measured the polarization-resolved angular elastic scattering intensity distribution of aggregates composed of primary particles with different shapes and packing densities in the near-backward directions (155 degrees-180 degrees). Specifically, we compare aggregates composed of spherical polystyrene latex spheres, cylinder-like Bacillus subtilis particles, and Arizona road dust, as well as tryptophan particles. We observe clearly differentiable polarization aspect ratios and find that the negative polarization dip is more pronounced in more densely packed aggregates or particles. This work indicates that the polarization aspect ratio in the near-backward direction may be used as a fingerprint to discriminate between aggregates with the same size and overall shape by differences in their constituent particles. (C) 2014 Optical Society of America C1 [Redding, Brandon; Cao, Hui] Yale Univ, Dept Appl Phys, New Haven, CT 06520 USA. [Pan, Yong-Le; Wang, Chuji] US Army, Res Lab, Adelphi, MD 20783 USA. [Wang, Chuji] Mississippi State Univ, Dept Phys, Starkville, MS 39759 USA. RP Cao, H (reprint author), Yale Univ, Dept Appl Phys, New Haven, CT 06520 USA. EM hui.cao@yale.edu FU Army Research Office [W911NF-12-1-0507] FX We thank Gorden Videen and Richard Chang for useful discussions. This work was supported by the Army Research Office under Grant No. W911NF-12-1-0507. NR 17 TC 1 Z9 1 U1 2 U2 7 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 EI 1539-4794 J9 OPT LETT JI Opt. Lett. PD JUL 15 PY 2014 VL 39 IS 14 BP 4076 EP 4079 DI 10.1364/OL.39.004076 PG 4 WC Optics SC Optics GA AL2CS UT WOS:000338934100005 PM 25121655 ER PT J AU Hauck, BC Davis, EJ Clark, AE Siems, WF Harden, CS McHugh, VM Hill, HH AF Hauck, Brian C. Davis, Eric J. Clark, Aurora E. Siems, William F. Harden, Charles S. McHugh, Vincent M. Hill, Herbert H., Jr. TI Determining the water content of a drift gas using reduced ion mobility measurements SO INTERNATIONAL JOURNAL OF MASS SPECTROMETRY LA English DT Article DE Ion mobility spectrometry; Time-of-flight mass spectrometry; Atmospheric measurements; Water content; DMMP ID CHEMICAL WARFARE AGENTS; DIMETHYL METHYLPHOSPHONATE; ELECTROSPRAY-IONIZATION; ILLICIT DRUGS; SPECTROMETRY; PHASE; EXPLOSIVES; SOLVATION; HYDROGEN; DENSITY AB Ion mobility spectrometry is widely used in national defense areas, and field-deployed IMS units are subject to various environmental conditions; one of the most important and least controlled being the humidity of the sample and drift gas. Varying drift gas water content can significantly alter the drift time and reduce the mobility constant (K-0 value) of the ion. While the effect of drift gas water content has been previously characterized, no means to quantitatively measure the water content of the drift gas under field conditions have been developed. In this work, using an IMS-TOFMS instrument capable of high precision (+/- 0.005 cm(2) V-1 s(-1) better) measurements of K-0 values, we investigated the protonated monomer and proton-bound dimer ions of dimethyl methylphosphonate as standards that are sensitive and insensitive, respectively, to the formation of water cluster ions. It was found that the ratio of mobilities of these two ions could measure the water content of the drift gas in field-deployed instruments. When water vapor was added in the presence of an ammonia dopant, K-0 was found to decrease as a function of water content to a lesser degree than under conditions without dopant. This study was conducted at atmospheric pressure and at temperatures from 30 degrees C to 150 degrees C. The experimental data were supported by complementary density functional theory calculations that examined the interactions of the DMMP monomer with successive number of waters. The reduced ion mobility cross-sections in N-2 were subsequently predicted using the trajectory method. (C) 2014 Elsevier B.V. All rights reserved. C1 [Hauck, Brian C.; Clark, Aurora E.; Siems, William F.; Hill, Herbert H., Jr.] Washington State Univ, Dept Chem, Pullman, WA 99164 USA. [Davis, Eric J.] Fresno Pacif Univ, Fresno, CA 93702 USA. [Harden, Charles S.] US Army, ECBC Operat, LEIDOS, Gunpowder, MD 21010 USA. [McHugh, Vincent M.] US Army, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Hill, HH (reprint author), Washington State Univ, Dept Chem, 305 Fulmer Hall, Pullman, WA 99164 USA. EM brian.hauck@wsu.edu; hhhill@wsu.edu FU LEIDOS; U.S. Army Edgewood Chemical Biological Center; U.S. Army Research Laboratory's Army Research Office [W911NF-12-1-0575] FX Funding for this effort was provided by Science Applications International Corporation, now LEIDOS, as a subcontract under a Task Order contract with U.S. Army Edgewood Chemical Biological Center and has been continued with the U.S. Army Research Laboratory's Army Research Office under grant #W911NF-12-1-0575. NR 32 TC 2 Z9 2 U1 2 U2 32 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1387-3806 EI 1873-2798 J9 INT J MASS SPECTROM JI Int. J. Mass Spectrom. PD JUL 15 PY 2014 VL 368 BP 37 EP 44 DI 10.1016/j.ijms.2014.05.010 PG 8 WC Physics, Atomic, Molecular & Chemical; Spectroscopy SC Physics; Spectroscopy GA AK7KC UT WOS:000338606200006 ER PT J AU Ferguson, JB Thao, X Rohatgi, PK Cho, K Kim, CS AF Ferguson, J. B. Thao, Xee Rohatgi, Pradeep K. Cho, Kyu Kim, Chang-Soo TI Computational and analytical prediction of the elastic modulus and yield stress in particulate-reinforced metal matrix composites SO SCRIPTA MATERIALIA LA English DT Article DE Finite-element analysis; Mechanical properties; Modeling; Metal matrix composites ID MELTED SIC/AL COMPOSITES; BEHAVIOR; MAGNESIUM; STRENGTH; TENSILE; ALLOY; PM AB In this work, three-dimensional finite-element analysis (FEA) simulations based on the representative volume element approach have been performed to determine the elastic modulus and yield stress of spherical particle-reinforced metal matrix composites. These simulations take into consideration of the degree of bonding between the matrix and the reinforcement. An analytical model has been developed using the FEA computations, and the results agree well with experimental findings reported in the literature for strongly bonded Al-2080/SiC and poorly bonded Al-2024/Al2O3 materials. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Ferguson, J. B.; Thao, Xee; Rohatgi, Pradeep K.; Kim, Chang-Soo] Univ Wisconsin, Dept Mat Sci & Engn, Milwaukee, WI 53211 USA. [Cho, Kyu] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Kim, CS (reprint author), Univ Wisconsin, Dept Mat Sci & Engn, Milwaukee, WI 53211 USA. EM kimcs@uwm.edu FU United States Army Research Laboratory [W911NF-08-2-0014] FX This material is based upon work supported by the United States Army Research Laboratory under Cooperative Agreement No. W911NF-08-2-0014. The views, opinions and conclusions made in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 14 TC 6 Z9 6 U1 3 U2 26 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6462 J9 SCRIPTA MATER JI Scr. Mater. PD JUL 15 PY 2014 VL 83 BP 45 EP 48 DI 10.1016/j.scriptamat.2014.04.004 PG 4 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA AI4IT UT WOS:000336829600012 ER PT J AU Lin, J Walsh, L Hughes, G Woicik, JC Povey, IM O'Regan, TP Hurley, PK AF Lin, Jun Walsh, Lee Hughes, Greg Woicik, Joseph C. Povey, Ian M. O'Regan, Terrance P. Hurley, Paul K. TI A combined capacitance-voltage and hard x-ray photoelectron spectroscopy characterisation of metal/Al2O3/In0.53Ga0.47As capacitor structures SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID ELECTRICAL-PROPERTIES AB Capacitance-Voltage (C-V) characterization and hard x-ray photoelectron spectroscopy (HAXPES) measurements have been used to study metal/Al2O3/In0.53Ga0.47As capacitor structures with high (Ni) and low (Al) work function metals. The HAXPES measurements observe a band bending occurring prior to metal deposition, which is attributed to a combination of fixed oxide charges and interface states of donor-type. Following metal deposition, the Fermi level positions at the Al2O3/In0.53Ga0.47As interface move towards the expected direction as observed from HAXPES measurements. The In0.53Ga0.47As surface Fermi level positions determined from both the C-V analysis at zero gate bias and HAXPES measurements are in reasonable agreement. The results are consistent with the presence of electrically active interface states at the Al2O3/In0.53Ga0.47As interface and suggest an interface state density increasing towards the In0.53Ga0.47As valence band edge. (C) 2014 AIP Publishing LLC. C1 [Lin, Jun; Povey, Ian M.; Hurley, Paul K.] Natl Univ Ireland Univ Coll Cork, Tyndall Natl Inst, Cork, Ireland. [Walsh, Lee; Hughes, Greg] Dublin City Univ, Sch Phys Sci, Dublin 9, Ireland. [Woicik, Joseph C.] NIST, Gaithersburg, MD 20899 USA. [O'Regan, Terrance P.] US Army Res Lab, Adelphi, MD 20783 USA. RP Lin, J (reprint author), Natl Univ Ireland Univ Coll Cork, Tyndall Natl Inst, Cork, Ireland. RI Povey, Ian/C-6439-2009; OI Povey, Ian/0000-0002-7877-6664; Hughes, Greg/0000-0003-1310-8961; Hughes, Gregory/0000-0002-1358-9032 FU Science Foundation Ireland through INVENT Project [SFI/09/IN.1/I2633]; U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-98CH10886] FX The authors from Tyndall National Institute and Dublin City University acknowledge Science Foundation Ireland for financial support of the research work through the INVENT Project (SFI/09/IN.1/I2633). The central fabrication facility at Tyndall is acknowledged for the fabrication of the experimental samples used in this work. Ian Povey from Tyndall is acknowledged for the ALD growth of the Al2O3 layers. Dan O'Connell from Tyndall is acknowledged for the metallisation. Patrick Carolan from Tyndall is acknowledged for the TEM analysis. Access to the X24A HAXPES beamline at Brookhaven National Laboratory was obtained through a General User Proposal. Use of the National Synchrotron Light Source, Brookhaven National Laboratory, was supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No. DE-AC02-98CH10886. NR 30 TC 0 Z9 0 U1 0 U2 16 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD JUL 14 PY 2014 VL 116 IS 2 AR 024104 DI 10.1063/1.4887517 PG 8 WC Physics, Applied SC Physics GA AN0II UT WOS:000340267600054 ER PT J AU Gust, KA Najar, FZ Habib, T Lotufo, GR Piggot, AM Fouke, BW Laird, JG Wilbanks, MS Rawat, A Indest, KJ Roe, BA Perkins, EJ AF Gust, Kurt A. Najar, Fares Z. Habib, Tanwir Lotufo, Guilherme R. Piggot, Alan M. Fouke, Bruce W. Laird, Jennifer G. Wilbanks, Mitchell S. Rawat, Arun Indest, Karl J. Roe, Bruce A. Perkins, Edward J. TI Coral-zooxanthellae meta-transcriptomics reveals integrated response to pollutant stress SO BMC GENOMICS LA English DT Article DE Coral holobiont; Marine pollution; Meta-transcriptomics; Acropora; Zooxanthellae; RDX; Symbiosis; Transcriptional network; Next generation sequencing ID ACROPORA-MILLEPORA; NORTHERN BOBWHITE; HUMAN FOOTPRINT; CLIMATE-CHANGE; REEF CORALS; RED-SEA; GENOME; ACIDIFICATION; CONSTRUCTION; NETWORKS AB Background: Corals represent symbiotic meta-organisms that require harmonization among the coral animal, photosynthetic zooxanthellae and associated microbes to survive environmental stresses. We investigated integrated-responses among coral and zooxanthellae in the scleractinian coral Acropora formosa in response to an emerging marine pollutant, the munitions constituent, 1,3,5-trinitro-1,3,5 triazine (RDX; 5 day exposures to 0 (control), 0.5, 0.9, 1.8, 3.7, and 7.2 mg/L, measured in seawater). Results: RDX accumulated readily in coral soft tissues with bioconcentration factors ranging from 1.1 to 1.5. Next-generation sequencing of a normalized meta-transcriptomic library developed for the eukaryotic components of the A. formosa coral holobiont was leveraged to conduct microarray-based global transcript expression analysis of integrated coral/zooxanthellae responses to the RDX exposure. Total differentially expressed transcripts (DET) increased with increasing RDX exposure concentrations as did the proportion of zooxanthellae DET relative to the coral animal. Transcriptional responses in the coral demonstrated higher sensitivity to RDX compared to zooxanthellae where increased expression of gene transcripts coding xenobiotic detoxification mechanisms (i.e. cytochrome P450 and UDP glucuronosyltransferase 2 family) were initiated at the lowest exposure concentration. Increased expression of these detoxification mechanisms was sustained at higher RDX concentrations as well as production of a physical barrier to exposure through a 40% increase in mucocyte density at the maximum RDX exposure. At and above the 1.8 mg/L exposure concentration, DET coding for genes involved in central energy metabolism, including photosynthesis, glycolysis and electron-transport functions, were decreased in zooxanthellae although preliminary data indicated that zooxanthellae densities were not affected. In contrast, significantly increased transcript expression for genes involved in cellular energy production including glycolysis and electron-transport pathways was observed in the coral animal. Conclusions: Transcriptional network analysis for central energy metabolism demonstrated highly correlated responses to RDX among the coral animal and zooxanthellae indicative of potential compensatory responses to lost photosynthetic potential within the holobiont. These observations underscore the potential for complex integrated responses to RDX exposure among species comprising the coral holobiont and highlight the need to understand holobiont-species interactions to accurately assess pollutant impacts. C1 [Gust, Kurt A.; Lotufo, Guilherme R.; Laird, Jennifer G.; Wilbanks, Mitchell S.; Indest, Karl J.; Perkins, Edward J.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Najar, Fares Z.] Univ Oklahoma, Adv Ctr Genome Technol, Norman, OK 73019 USA. [Habib, Tanwir] Badger Tech Serv, San Antonio, TX 78216 USA. [Piggot, Alan M.; Fouke, Bruce W.; Roe, Bruce A.] Univ Illinois, Dept Geol, Urbana, IL 31801 USA. [Piggot, Alan M.] Univ Miami, Div Marine Geol & Geophys, Miami, FL 33149 USA. [Fouke, Bruce W.] Univ Illinois, Inst Genom Biol, Urbana, IL 61801 USA. [Rawat, Arun] Translat Genom Res Inst, Phoenix, AZ 85004 USA. RP Gust, KA (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. EM kurt.a.gust@usace.army.mil OI Rawat, Arun/0000-0003-0540-2044 FU US Navy, Office of Naval Research [N00014-06-1-0135]; U.S. Army, Environmental Quality Research Program FX We thank the US Navy, Office of Naval Research for grant support (N00014-06-1-0135) as well as support from the U.S. Army, Environmental Quality Research Program, Effects of Munitions Compounds on Biological Networks Focus Area. We also thank Joan Clarke for consultation on statistical methods. Permission for publishing this information has been granted by the Chief of Engineers. NR 54 TC 5 Z9 5 U1 1 U2 31 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2164 J9 BMC GENOMICS JI BMC Genomics PD JUL 12 PY 2014 VL 15 AR 591 DI 10.1186/1471-2164-15-591 PG 18 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA AM1DR UT WOS:000339587100002 PM 25016412 ER PT J AU Hartley, DJ Janssens, RVF Riedinger, LL Riley, MA Wang, X Miller, S Ayangeakaa, AD Carpenter, MP Carroll, JJ Cavey, J Chiara, CJ Chowdhury, P Garg, U Hota, SS Jackson, EG Kondev, FG Lauritsen, T Litz, M Ma, WC Matta, J Paul, ES Pedicini, EE Simpson, J Vanhoy, JR Zhu, S AF Hartley, D. J. Janssens, R. V. F. Riedinger, L. L. Riley, M. A. Wang, X. Miller, S. Ayangeakaa, A. D. Carpenter, M. P. Carroll, J. J. Cavey, J. Chiara, C. J. Chowdhury, P. Garg, U. Hota, S. S. Jackson, E. G. Kondev, F. G. Lauritsen, T. Litz, M. Ma, W. C. Matta, J. Paul, E. S. Pedicini, E. E. Simpson, J. Vanhoy, J. R. Zhu, S. TI High-spin structure of odd-odd Re-172 SO PHYSICAL REVIEW C LA English DT Article AB A significant extension of the level scheme for the odd-odd nucleus Re-172 was accomplished through the use of the Gammasphere spectrometer. States up to a tentative spin assignment of 39 were observed and two new structures were identified. Configuration assignments are proposed based on alignment properties and observed band crossings. C1 [Hartley, D. J.; Cavey, J.; Pedicini, E. E.; Vanhoy, J. R.] US Naval Acad, Dept Phys, Annapolis, MD 21402 USA. [Janssens, R. V. F.; Carpenter, M. P.; Chiara, C. J.; Lauritsen, T.; Zhu, S.] Argonne Natl Lab, Div Phys, Argonne, IL 60439 USA. [Riedinger, L. L.] Univ Tennessee, Dept Phys & Astron, Knoxville, TN 37996 USA. [Riley, M. A.; Wang, X.; Miller, S.] Florida State Univ, Dept Phys, Tallahassee, FL 32306 USA. [Ayangeakaa, A. D.; Garg, U.; Matta, J.] Univ Notre Dame, Dept Phys, Notre Dame, IN 46556 USA. [Carroll, J. J.; Litz, M.] Army Res Lab, Adelphi, MD 20783 USA. [Chiara, C. J.] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA. [Chiara, C. J.; Kondev, F. G.] Argonne Natl Lab, Nucl Engn Div, Argonne, IL 60439 USA. [Chowdhury, P.; Hota, S. S.; Jackson, E. G.] Univ Massachusetts, Dept Phys, Lowell, MA 01854 USA. [Ma, W. C.] Mississippi State Univ, Dept Phys, Mississippi State, MS 39762 USA. [Paul, E. S.] Univ Liverpool, Oliver Lodge Lab, Liverpool L69 7ZE, Merseyside, England. [Simpson, J.] STFC Daresbury Lab, Warrington WA4 4AD, Cheshire, England. RP Hartley, DJ (reprint author), US Naval Acad, Dept Phys, Annapolis, MD 21402 USA. RI Carpenter, Michael/E-4287-2015; Ayangeakaa, Akaa/F-3683-2015 OI Carpenter, Michael/0000-0002-3237-5734; Ayangeakaa, Akaa/0000-0003-1679-3175 FU National Science Foundation [PHY-1203100, PHY-0754674, PHY-1068192]; U.S. Department of Energy, Office of Nuclear Physics [DE-AC02-06CH11357, DE-FG02-94ER40848, DE-FG02-96ER40983, DE-FG02-94ER40834, DE-FG02-95ER40939]; United Kingdom Science and Technology Facilities Council FX The authors thank the ANL operations staff at Gammasphere and gratefully acknowledge the efforts of J. P. Greene for target preparation. We thank D. C. Radford and H. Q. Jin for their software support. This work is funded by the National Science Foundation under Grants No. PHY-1203100 (USNA), No. PHY-0754674 (FSU), and No. PHY-1068192 (ND), as well as by the U.S. Department of Energy, Office of Nuclear Physics, under Contracts No. DE-AC02-06CH11357 (ANL), No. DE-FG02-94ER40848 (UML), No. DE-FG02-96ER40983 (UT), No. DE-FG02-94ER40834 (UMCP), and No. DE-FG02-95ER40939 (MSU), as well as the United Kingdom Science and Technology Facilities Council. NR 14 TC 2 Z9 2 U1 3 U2 7 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0556-2813 EI 1089-490X J9 PHYS REV C JI Phys. Rev. C PD JUL 11 PY 2014 VL 90 IS 1 AR 017301 DI 10.1103/PhysRevC.90.017301 PG 5 WC Physics, Nuclear SC Physics GA AQ7MQ UT WOS:000343002300010 ER PT J AU Taylor, DE Strawhecker, KE Shanholtz, ER Sorescu, DC Sausa, RC AF Taylor, D. E. Strawhecker, K. E. Shanholtz, E. R. Sorescu, D. C. Sausa, R. C. TI Investigations of the Intermolecular Forces between RDX and Polyethylene by Force-Distance Spectroscopy and Molecular Dynamics Simulations SO JOURNAL OF PHYSICAL CHEMISTRY A LA English DT Article ID PLASTIC-BONDED EXPLOSIVES; SURFACE-ENERGY; CRYSTAL-STRUCTURE; CYCLOTRIMETHYLENE-TRINITRAMINE; DENSITY POLYETHYLENE; ADHESION; MICROSCOPE; PARTICLES; PHASE; HMX AB The development of novel nanoenergetic materials with enhanced bulk properties requires an understanding of the intermolecular interactions occurring between molecular components. We investigate the surface interactions between 1,3,5-trinitro-1,3,5-triazacyclohexane (RDX) and polyethylene (PE) crystals on the basis of combined use of molecular dynamics (MD) simulations and force-distance spectroscopy, in conjunction with Lifshitz macroscopic theory of van der Waals forces between continuous materials. The binding energy in the RDX-PE system depends both on the degree of PE crystallinity and on the RDX crystal face. Our MD simulations yield binding energies of approximately 132 and 120 mJ/m(2) for 100% amorphous and 100% crystalline PE on RDX (210), respectively. The average value is about 36% greater than our experimental value of 81 +/- 15 mJ/m(2) for PE (similar to 48% amorphous) on RDX (210). By comparison, Liftshitz theory predicts a value of about 79 mJ/m(2) for PE interacting with RDX. Our MD simulations also predict larger binding energies for both amorphous and crystalline PE on RDX (210) compared to the RDX (001) surface. Analysis of the interaction potential indicates that about 60% of the binding energy in the PE-RDX system is due to attractive interactions between H-PE-O-RDX and C-PE-N-RDX pairs of atoms. Further, amorphous PE shows a much longer interaction distance than crystalline PE with the (210) and (001) RDX surfaces due to the possibility of larger polymer elongations in the case of amorphous PE as strain is applied. Also, we report estimates of the binding energies of energetic materials RDX and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) with PE, propylene, polystyrene, and several fluorine-containing polymers using Lifshitz theory and compare these with reported MD calculations. C1 [Taylor, D. E.; Sausa, R. C.] Army Res Lab, ARL RDL WML B, Aberdeen Proving Ground, MD 21005 USA. [Strawhecker, K. E.] Army Res Lab, ARL RDL WMM EG, Aberdeen Proving Ground, MD 21005 USA. [Shanholtz, E. R.] Army Res Lab, ARL RDL WMM EUS, Aberdeen Proving Ground, MD 21005 USA. [Sorescu, D. C.] US DOE, Natl Energy Technol Lab, Pittsburgh, PA 15236 USA. [Sorescu, D. C.] Univ Pittsburgh, Dept Chem & Petr Engn, Pittsburgh, PA 15261 USA. RP Sausa, RC (reprint author), Army Res Lab, ARL RDL WML B, Aberdeen Proving Ground, MD 21005 USA. EM rosario.c.sausa.civ@mail.mil FU ARL Multiscale Response of Energetic Materials Program; ARL-Oak Ridge Institute for Science and Education Program FX We thank Drs. R. Pesce-Rodriquez of the Army Research Laboratory (ARL) and K. Behler of ARL-Bowhead Science & Technology for many helpful discussions, and Dr. K. Ramos of the Los Alamos National Laboratory for providing us with the RDX crystals. Support from the ARL Multiscale Response of Energetic Materials Program and the ARL-Oak Ridge Institute for Science and Education Program is gratefully acknowledged. We also acknowledge with thanks a supercomputing challenge grant at several DOD Supercomputing Resource Centers (DSRCs). NR 69 TC 1 Z9 1 U1 4 U2 46 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1089-5639 J9 J PHYS CHEM A JI J. Phys. Chem. A PD JUL 10 PY 2014 VL 118 IS 27 BP 5083 EP 5097 DI 10.1021/jp5039317 PG 15 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA AL2UK UT WOS:000338980800024 PM 24922563 ER PT J AU Hlepas, G Truster, T Masud, A AF Hlepas, Georgette Truster, Timothy Masud, Arif TI A heterogeneous modeling method for porous media flows SO INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN FLUIDS LA English DT Article DE multiscale methods; variational methods; heterogeneous methods; Darcy flow; Darcy-Stokes flow ID FINITE-ELEMENT-METHOD; VARIATIONAL MULTISCALE METHOD; DARCY FLOW; STABILIZED METHODS; SOURCE TERMS; FORMULATION; FRAMEWORK; MECHANICS; EQUATIONS; BUBBLES AB This paper presents a new heterogeneous multiscale modeling method for porous media flows. Physics at the global level is governed by one set of PDEs, while features in the solution that are beyond the resolution capacity of the global model are accounted for by the next refined set of governing equations. In this method, the global or coarse model is given by the Darcy equation, while the local or refined model is given by the Darcy-Stokes equation. Concurrent domain decomposition where global and local models are applied to adjacent subdomains, as well as overlapping domain decomposition where global and local models coexist on overlapping domains, is considered. An interface operator is developed for the case where global and local models commute along the common interface. For the overlapping decomposition, a residual-based coupling technique is developed that consistently facilitates bottom-up embedding of scale effects from the local Darcy-Stokes model into the global Darcy model. Numerical results are presented for nonoverlapping and overlapping domain decompositions for various benchmark problems. Computed results show that the hierarchically coupled models accurately account for the heterogeneity of the medium and efficiently incorporate local features into the global response. Copyright (c) 2014 John Wiley & Sons, Ltd. C1 [Hlepas, Georgette] US Army Corps Engineers, Chicago, IL 60606 USA. [Hlepas, Georgette] Univ Illinois, Dept Civil & Mat Engn, Chicago, IL 60612 USA. [Truster, Timothy] Univ Tennessee, Dept Civil & Environm Engn, Knoxville, TN 37996 USA. [Truster, Timothy; Masud, Arif] Univ Illinois, Dept Civil & Environm Engn, Urbana, IL 61801 USA. RP Masud, A (reprint author), Univ Illinois, Dept Civil & Environm Engn, Urbana, IL 61801 USA. EM amasud@illinois.edu FU Department of Defense SMART scholarship program; NSF Graduate Research Fellowship FX G. Hlepas was supported by the Department of Defense SMART scholarship program. T. Truster was sponsored by an NSF Graduate Research Fellowship. These supports are gratefully acknowledged. NR 35 TC 2 Z9 2 U1 0 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0271-2091 EI 1097-0363 J9 INT J NUMER METH FL JI Int. J. Numer. Methods Fluids PD JUL 10 PY 2014 VL 75 IS 7 BP 487 EP 518 DI 10.1002/fld.3904 PG 32 WC Computer Science, Interdisciplinary Applications; Mathematics, Interdisciplinary Applications; Mechanics; Physics, Fluids & Plasmas SC Computer Science; Mathematics; Mechanics; Physics GA AJ2ZL UT WOS:000337534100002 ER PT J AU Taylor, G Hipp, D Moser, A Dickerson, K Gerhardstein, P AF Taylor, Gemma Hipp, Daniel Moser, Alecia Dickerson, Kelly Gerhardstein, Peter TI The development of contour processing: evidence from physiology and psychophysics SO FRONTIERS IN PSYCHOLOGY LA English DT Review DE contour detection; closure; horizontal connections; development; visual development ID PRIMARY VISUAL-CORTEX; YOUNG INFANTS PERCEPTION; MONKEY STRIATE CORTEX; TOP-DOWN INFLUENCES; LATERAL INTERACTIONS; FUNCTIONAL ARCHITECTURE; CONTEXTUAL INTERACTIONS; SPATIAL INTEGRATION; INTRINSIC CONNECTIONS; CONTRAST SENSITIVITY AB Object perception and pattern vision depend fundamentally upon the extraction of contours from the visual environment. In adulthood, contour or edge-level processing is supported by the Gestalt heuristics of proximity, collinearity, and closure. Less is known, however, about the developmental trajectory of contour detection and contour integration. Within the physiology of the visual system, long-range horizontal connections in V1 and V2 are the likely candidates for implementing these heuristics. While post-mortem anatomical studies of human infants suggest that horizontal interconnections reach maturity by the second year of life, psychophysical research with infants and children suggests a considerably more protracted development. In the present review, data from infancy to adulthood will be discussed in order to track the development of contour detection and integration. The goal of this review is thus to integrate the development of contour detection and integration with research regarding the development of underlying neural circuitry. We conclude that the ontogeny of this system is best characterized as a developmentally extended period of associative acquisition whereby horizontal connectivity becomes functional over longer and longer distances, thus becoming able to effectively integrate over greater spans of visual space. C1 [Taylor, Gemma; Hipp, Daniel; Moser, Alecia; Gerhardstein, Peter] SUNY Binghamton, Dept Psychol, Binghamton, NY 13902 USA. [Dickerson, Kelly] RDRL HRS D, Dept Army, US Army Res Lab, Aberdeen Proving Ground, MD USA. RP Gerhardstein, P (reprint author), SUNY Binghamton, Dept Psychol, Binghamton, NY 13902 USA. EM gerhard@binghamton.edu OI Taylor, Gemma/0000-0002-0988-7168 NR 115 TC 1 Z9 1 U1 3 U2 25 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1664-1078 J9 FRONT PSYCHOL JI Front. Psychol. PD JUL 8 PY 2014 VL 5 DI 10.3389/fpsyg.2014.00719 PG 10 WC Psychology, Multidisciplinary SC Psychology GA AL2HY UT WOS:000338947800001 ER PT J AU Jackson, AC Walck, SD Strawhecker, KE Butler, BG Lambeth, RH Beyer, FL AF Jackson, Aaron C. Walck, Scott D. Strawhecker, Kenneth E. Butler, Brady G. Lambeth, Robert H. Beyer, Frederick L. TI Metallopolymers Containing Excess Metal-Ligand Complex for Improved Mechanical Properties SO MACROMOLECULES LA English DT Article ID INDUCED SUPRAMOLECULAR POLYMERIZATION; HYDROGEN-BONDING INTERACTIONS; SMALL-ANGLE SCATTERING; PI-PI STACKING; COORDINATION POLYMERS; SELF-ORGANIZATION; CHAIN AB This work incorporates ML complexes as unbound entities that interact with ML complexes bound to the backbone of the polymer. The pi-pi interactions and Coulombic forces between bound and unbound ML complexes hold the ML-rich phase together and result in improved mechanical properties over polymers containing only the bound ML complexes. The ML-rich phase formed ordered, cylindrical domains. The storage modulus, surface elastic modulus, and high temperature stability of these metallopolymers increased with increasing concentration of ML complex in the polymer while an optimal concentration and morphology are necessary to improve the strength and creep resistance of the polymer. Ultimately, the successful addition and patterning of unbound ML complexes as a hard phase in a polymer matrix provides an important template for the design of a new type of supramolecular nanocomposite. C1 [Jackson, Aaron C.; Walck, Scott D.; Strawhecker, Kenneth E.; Butler, Brady G.; Lambeth, Robert H.; Beyer, Frederick L.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen, MD 21005 USA. RP Jackson, AC (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen, MD 21005 USA. EM aa.jckson@gmail.com FU Postgraduate Research Participation Program at the US Army Research Laboratory [ORISE 1120-1120-99] FX A.C.J. is supported by the Postgraduate Research Participation Program at the US Army Research Laboratory, administered by the Oak Ridge Institute of Science and Education through an interagency agreement between the US Department of Energy and Army Research Laboratory (Contract ORISE 1120-1120-99). NR 45 TC 6 Z9 6 U1 1 U2 26 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0024-9297 EI 1520-5835 J9 MACROMOLECULES JI Macromolecules PD JUL 8 PY 2014 VL 47 IS 13 BP 4144 EP 4150 DI 10.1021/ma500516p PG 7 WC Polymer Science SC Polymer Science GA AL0GW UT WOS:000338806400003 ER PT J AU Anderson, EM Lundquist, AM Sarney, WL Svensson, SP Carrington, PJ Pearson, C Millunchick, JM AF Anderson, Evan M. Lundquist, Adam M. Sarney, Wendy L. Svensson, Stefan P. Carrington, Peter J. Pearson, Chris Millunchick, Joanna M. TI Influence of a Bi surfactant on Sb incorporation in InAsSb alloys SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID MOLECULAR-BEAM EPITAXY; BISMUTH SURFACTANT; GROWTH AB The influence of using a Bi surfactant during the growth of InAsSb on the composition was examined, and it was found that increasing Bi flux on the surface during growth inhibits the incorporation of Sb. Analysis of the data via a kinetic model of anion incorporation shows that surface Bi acts as a catalyst for InAs formation, thus inhibiting Sb incorporation. (C) 2014 AIP Publishing LLC. C1 [Anderson, Evan M.; Lundquist, Adam M.; Millunchick, Joanna M.] Univ Michigan, Dept Mat Sci & Engn, Ann Arbor, MI 48109 USA. [Sarney, Wendy L.; Svensson, Stefan P.] US Army Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. [Carrington, Peter J.] UCL, Dept Elect & Elect Engn, London WC1E 7JE, England. [Pearson, Chris] Univ Michigan, Dept Comp Sci Engn & Phys, Flint, MI 48502 USA. RP Anderson, EM (reprint author), Univ Michigan, Dept Mat Sci & Engn, Ann Arbor, MI 48109 USA. OI Anderson, Evan/0000-0002-3771-3085; Carrington, Peter/0000-0003-2107-5602 FU Department of Defense, Army Research Office [W911NF-12-1-0338] FX E.M.A., A.M.L., C.P., and J.M.M. gratefully acknowledge Chakrapani Varanasi and the support of the Department of Defense, Army Research Office via the Grant No. W911NF-12-1-0338. NR 15 TC 4 Z9 4 U1 2 U2 13 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD JUL 7 PY 2014 VL 116 IS 1 AR 014901 DI 10.1063/1.4886635 PG 4 WC Physics, Applied SC Physics GA AM1QB UT WOS:000339621400063 ER PT J AU Moretti, JD Sabatini, JJ Poret, JC AF Moretti, Jared D. Sabatini, Jesse J. Poret, Jay C. TI High-Performing Red-Light-Emitting Pyrotechnic Illuminants through the Use of Perchlorate-Free Materials SO CHEMISTRY-A EUROPEAN JOURNAL LA English DT Article DE formulations; green chemistry; illuminants; potassium; pyrotechnics ID CIVILIAN APPLICATIONS; PERIODATE SALTS; NITROGEN; MILITARY AB The development of perchlorate-free M662 40 mm illuminating pyrotechnic compositions is described. On the bases of cost, performance, and sensitivity, potassium periodate was determined to be most effective potassium perchlorate replacement in the compositions tested. The optimal periodate-based composition exceeded the performance of the perchlorate-containing control, exhibited low sensitivity values to impact, friction, and electrostatic discharge, and had high thermal onset temperatures. C1 [Moretti, Jared D.; Sabatini, Jesse J.; Poret, Jay C.] US Army, Pyrotech Technol & Prototyping Div, RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA. RP Sabatini, JJ (reprint author), US Army, Pyrotech Technol & Prototyping Div, RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA. EM jesse.j.sabatini.civ@mail.mil FU US Army FX The authors thank Dr. Karl Oyler (ARDEC) for acquiring particle size information of all relevant ingredients, and express their gratitude to Mr. Henry A. Grau (ARDEC) for providing thermal onset data. The efforts by Mr. Eric A. Latalladi (ARDEC) and Mr. Stephen C. Taggart (ARDEC) for their assistance in the preparation of pyrotechnic mixes are greatly appreciated. The authors are indebted to the US Army for funding of this work. NR 29 TC 5 Z9 5 U1 0 U2 6 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 0947-6539 EI 1521-3765 J9 CHEM-EUR J JI Chem.-Eur. J. PD JUL 7 PY 2014 VL 20 IS 28 BP 8800 EP 8804 DI 10.1002/chem.201402654 PG 5 WC Chemistry, Multidisciplinary SC Chemistry GA AK9TC UT WOS:000338768900040 PM 24939042 ER PT J AU Wang, XY Bynum, JA Stavchansky, S Bowman, PD AF Wang, Xinyu Bynum, James A. Stavchansky, Solomon Bowman, Phillip D. TI Cytoprotection of human endothelial cells against oxidative stress by 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO-Im): Application of systems biology to understand the mechanism of action SO EUROPEAN JOURNAL OF PHARMACOLOGY LA English DT Article DE CDDO-Im; CAPE; Cytoprotection; Oxidative stress; Heme oxygenase-1; Gene expression analysis ID ACID PHENETHYL ESTER; HEME OXYGENASE-1; 2-CYANO-3,12-DIOXOOLEAN-1,9-DIEN-28-OIC ACID; SIGNAL-TRANSDUCTION; INDUCTION; IMIDAZOLIDE; APOPTOSIS; INDUCERS; CANCER; INJURY AB Cellular damage horn oxidative stress, in particular following ischemic injury, occurs during heart attack, stroke, or traumatic injury, and is potentially reducible with appropriate drug treatment. We previously reported that caffeic acid phenethyl ester (CAPE), a plant-derived polyphenolic compound, protected human umbilical vein endothelial cells (HUVEC) from menadione-induced oxidative stress and that this cytoprotective effect was correlated with the capacity to induce home oxygenase-1 (HMOX1) and its protein product, a phase It cytoprotective enzyme. To further improve this cytoprotective effect, we studied a synthetic triterpenoid,1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl[imidazole (CDDO-Im), which is known as a potent phase II enzyme inducer with antitumor and anti-inflammatory activities, and compared it to CAPE. CDDO-Im at 200 nM provided more protection to HUVEC against oxidative stress than 20 mu M CAPE. We explored the mechanism of CDDO-Im cytoprotection with gene expression profiling and pathway analysis and compared to that of CAPE. In addition to potent up-regulation of HMOX1, heat shock proteins (HSP) were also found to be highly induced by CDDO-Im in HUVEC. Pathway analysis results showed that transcription factor Nrf2-mediated oxidative stress response was among the top canonical pathways commonly activated by both CDDO-Im and CAPE. Compared to CAPE, CDDO-Im up-regulated more HSP and some of them to a much higher extent. In addition, CDDO-Im treatment affected Nrf2 pathway more significantly. These findings may provide an explanation why CDDO-Im is a more potent cytoprotectant than CAPE against oxidative stress in HUVEC. (C) 2014 Elsevier B.V. All rights reserved C1 [Wang, Xinyu] Philadelphia Coll Osteopath Med, Sch Pharm, Dept Pharmaceut Sci, Suwanee, GA 30024 USA. [Bynum, James A.; Bowman, Phillip D.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Bynum, James A.; Stavchansky, Solomon] Univ Texas Austin, Coll Pharm, Div Pharmaceut, Austin, TX 77812 USA. RP Wang, XY (reprint author), Philadelphia Coll Osteopath Med, Sch Pharm, Dept Pharmaceut Sci, Georgia Campus,625 Old Peachtree Rd NW, Suwanee, GA 30024 USA. EM xinyuwa@pcom.edu; phillip.d.bowman4.vol@mail.mil NR 30 TC 3 Z9 4 U1 1 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0014-2999 EI 1879-0712 J9 EUR J PHARMACOL JI Eur. J. Pharmacol. PD JUL 5 PY 2014 VL 734 BP 122 EP 131 DI 10.1016/j.ejphar.2014.03.033 PG 10 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA AH8YC UT WOS:000336423100016 PM 24703885 ER PT J AU Ahmad, F Amin, MG Dogaru, T AF Ahmad, Fauzia Amin, Moeness G. Dogaru, Traian TI Partially sparse imaging of stationary indoor scenes SO EURASIP JOURNAL ON ADVANCES IN SIGNAL PROCESSING LA English DT Article DE Sparse reconstruction; Partial sparsity; Compressive sensing; Through-the-wall radar ID SYNTHETIC-APERTURE RADAR; BUILDING INTERIOR; MATCHING PURSUIT; SIGNAL RECOVERY; WALL; ALGORITHM; DESIGN; MODEL AB In this paper, we exploit the notion of partial sparsity for scene reconstruction associated with through-the-wall radar imaging of stationary targets under reduced data volume. Partial sparsity implies that the scene being imaged consists of a sparse part and a dense part, with the support of the latter assumed to be known. For the problem at hand, sparsity is represented by a few stationary indoor targets, whereas the high scene density is defined by exterior and interior walls. Prior knowledge of wall positions and extent may be available either through building blueprints or from prior surveillance operations. The contributions of the exterior and interior walls are removed from the data through the use of projection matrices, which are determined from wall- and corner-specific dictionaries. The projected data, with enhanced sparsity, is then processed using l (1) norm reconstruction techniques. Numerical electromagnetic data is used to demonstrate the effectiveness of the proposed approach for imaging stationary indoor scenes using a reduced set of measurements. C1 [Ahmad, Fauzia; Amin, Moeness G.] Villanova Univ, Ctr Adv Commun, Radar Imaging Lab, Villanova, PA 19085 USA. [Dogaru, Traian] US Army Res Lab, Adelphi, MD 20783 USA. RP Ahmad, F (reprint author), Villanova Univ, Ctr Adv Commun, Radar Imaging Lab, Villanova, PA 19085 USA. EM fauzia.ahmad@villanova.edu FU ARL [W911NF-11-1-0536]; ARO FX This work is supported by ARO and ARL under contract W911NF-11-1-0536. NR 52 TC 0 Z9 0 U1 3 U2 12 PU SPRINGER INTERNATIONAL PUBLISHING AG PI CHAM PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND SN 1687-6180 J9 EURASIP J ADV SIG PR JI EURASIP J. Adv. Signal Process. PD JUL 4 PY 2014 AR 100 DI 10.1186/1687-6180-2014-100 PG 15 WC Engineering, Electrical & Electronic SC Engineering GA AM6EJ UT WOS:000339955500001 ER PT J AU Jain, RB AF Jain, Ram B. TI Impact of pregnancy on the concentrations of selected phthalates SO TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY LA English DT Article DE high molecular weight phthalates; low molecular weight phthalates; diethyhexyl phthalates; pregnancy ID NUTRITION EXAMINATION SURVEY; NATIONAL-HEALTH; METABOLITE CONCENTRATIONS; URINARY LEVELS; URBAN COHORT; OLD DATA; EXPOSURE; WOMEN; CHILDREN; ASSOCIATION AB Developing fetus can be exposed to toxicants during pregnancy. Impact of human pregnancy on the concentrations of phthalate metabolites mono(carboxynonyl) (MCNP), mono(carboxyoctyl) (MCOP), mono-2-ethyl-5-carboxypentyl, mono-n-butyl, mono-(3-carboxy propyl), monoethyl, mono-2-ethyl-5-hydroxyhexyl, mono-2-ethylhexyl, monoisobutyl, mono-2-ethyl-5-oxohexyl phthalate, mono-benzyl, sum of low molecular weight phthalates ( n-ary sumation LMW), sum of high molecular weight phthalates ( n-ary sumation HMW), and sum of diethylhexyl phthalates was assessed. Data from the National Health and Nutrition Examination Survey for the years 2005-2010 were used for this purpose. Regression models with logs of these metabolites as dependent variables and age, race/ethnicity, education, pregnancy, smoking and iron storage status, study year, family poverty income ratio (PIR), body mass index, urine albumin, and urine creatinine as independent variables were fitted. Pregnant females were found to have significantly lower concentrations of n-ary sumation HMW and MCNP than non-pregnant females. Concentrations of n-ary sumation LMW during the third trimester of pregnancy were significantly lower than during the second trimester of pregnancy. C1 [Jain, Ram B.] Womack Army Med Ctr, Ft Bragg, NC 28307 USA. [Jain, Ram B.] Empiristat Inc, Mt Airy, MD USA. RP Jain, RB (reprint author), Womack Army Med Ctr, Ft Bragg, NC 28307 USA. EM ram.b.jain.ctr@mail.mil NR 37 TC 0 Z9 0 U1 1 U2 2 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0277-2248 EI 1029-0486 J9 TOXICOL ENVIRON CHEM JI Toxicol Environ. Chem. PD JUL 3 PY 2014 VL 96 IS 6 BP 962 EP 980 DI 10.1080/02772248.2014.982121 PG 19 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA AX8JS UT WOS:000347156500014 ER PT J AU Lesch, V Jeremias, S Moretti, A Passerini, S Heuer, A Borodin, O AF Lesch, Volker Jeremias, Sebastian Moretti, Arianna Passerini, Stefano Heuer, Andreas Borodin, Oleg TI A Combined Theoretical and Experimental Study of the Influence of Different Anion Ratios on Lithium Ion Dynamics in Ionic Liquids SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID TRANSPORT-PROPERTIES; RAMAN-SPECTROSCOPY; SALT-SOLUTIONS; ELECTROLYTES; SIMULATION; MIXTURES; SOLVENTS; FUTURE AB In this paper, we investigate via experimental and simulation techniques the transport properties, in terms of total ionic conductivity and ion diffusion coefficients, of ionic liquids doped with lithium salts. They are composed of two anions, bis(fluorosulfonyl)imide (FSI) and bis(trifluoromethanesulfonyl)imide (TFSI), and two cations, N-ethyl-N-methylimidazolium (emim) and lithium ions. The comparison of the experimental results with the simulations shows very good agreement over a wide temperature range and a broad range of compositions. The addition of TFSI gives rise to the formation of lithium dimers (Li+-TFSF--Li+). A closer analysis of such dimers shows that involved lithium ions move nearly as fast as single lithium ions, although they have a different coordination and much slower TFSI exchange rates. C1 [Lesch, Volker; Jeremias, Sebastian; Moretti, Arianna; Heuer, Andreas] Univ Munster, Inst Phys Chem, D-48149 Munster, Germany. [Passerini, Stefano] Karlsruhe Inst Technol, Helmholtz Inst Ulm, D-52425 Ulm, Germany. [Borodin, Oleg] US Army Res Lab, Elect Branch, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. RP Lesch, V (reprint author), Univ Munster, Inst Phys Chem, Corrensstr 28-30, D-48149 Munster, Germany. EM volkerlesch@wwu.de; stefano.passerini@kit.edu; andheuer@wwu.de RI Passerini, Stefano/A-3859-2015; Borodin, Oleg/B-6855-2012 OI Passerini, Stefano/0000-0002-6606-5304; Borodin, Oleg/0000-0002-9428-5291 FU BMBF [Forderkennzeichen: 03X4634A, Forderkennzeichen: 03X4631N] FX S.J., A.M., and S.P. would like to thank the financial support of BMBF within the project "MEET Hi-END - Materialien und Komponenten fur Batterien mit hoher Energiedichte" (Forderkennzeichen: 03X4634A). The work is financially supported by the SafeBatt project from BMBF (Forderkennzeichen: 03X4631N). NR 32 TC 23 Z9 23 U1 1 U2 40 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1520-6106 J9 J PHYS CHEM B JI J. Phys. Chem. B PD JUL 3 PY 2014 VL 118 IS 26 BP 7367 EP 7375 DI 10.1021/jp501075g PG 9 WC Chemistry, Physical SC Chemistry GA AK8QL UT WOS:000338693000016 PM 24905999 ER PT J AU Biggins, JB Kang, HS Ternei, MA DeShazer, D Brady, SF AF Biggins, John B. Kang, Hahk-Soo Ternei, Melinda A. DeShazer, David Brady, Sean F. TI The Chemical Arsenal of Burkholderia pseudomallei Is Essential for Pathogenicity SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY LA English DT Article ID NATURAL-PRODUCT DISCOVERY; LIPOPEPTIDE BIOSURFACTANTS; PSEUDOMONAS-AERUGINOSA; VIRULENCE FACTORS; PROTEASOME; GENOME; MELIOIDOSIS; GENE; BIOSYNTHESIS; AVIRULENT AB Increasing evidence has shown that small-molecule chemistry in microbes (i.e., secondary metabolism) can modulate the microbe-host response in infection and pathogenicity. The bacterial disease melioidosis is conferred by the highly virulent, antibiotic-resistant pathogen Burkholderia pseudomallei (BP). Whereas some macromolecular structures have been shown to influence BP virulence (e.g., secretion systems, cellular capsule, pill), the role of the large cryptic secondary metabolome encoded within its genome has been largely unexplored for its importance to virulence. Herein we demonstrate that BP-encoded small-molecule biosynthesis is indispensible for in vivo BP pathogenicity. Promoter exchange experiments were used to induce high-level molecule production from two gene dusters (MPN and SYR) found to be essential for in vivo virulence. NMR structural characterization of these metabolites identified a new class of lipopeptide biosurfactants/biofilm modulators (the malleipeptins) and syrbactin-type proteasome inhibitors, both of which represent overlooked small-molecule virulence factors for BP. Disruption of Burkholderia virulence by inhibiting the biosynthesis of these small-molecule biosynthetic pathways may prove to be an effective strategy for developing novel melioidosis-specific therapeutics. C1 [Biggins, John B.; Kang, Hahk-Soo; Ternei, Melinda A.; Brady, Sean F.] Rockefeller Univ, Howard Hughes Med Inst, Lab Genet Encoded Small Mol, New York, NY 10065 USA. [DeShazer, David] US Army, Bacteriol Div, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Brady, SF (reprint author), Rockefeller Univ, Howard Hughes Med Inst, Lab Genet Encoded Small Mol, 1230 York Ave, New York, NY 10065 USA. EM sbrady@rockefeller.edu OI Biggins, John B./0000-0002-0825-3593 FU Northeast Biodefense Center [U54-A1057158]; NIH [GM077516]; Defense Threat Reduction Agency (DTRA)/Joint Science and Technology Office for Chemical and Biological Defense (JSTO-CBD) [CBCALL12-LS1-2-0070] FX This work was supported by Northeast Biodefense Center (U54-A1057158, to S.F.B), NIH (GM077516, to S.F.B), and the Defense Threat Reduction Agency (DTRA)/Joint Science and Technology Office for Chemical and Biological Defense (JSTO-CBD, proposal no. CBCALL12-LS1-2-0070, to D.D.). Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. We thank Eugene Blue for assistance in conducting the mouse experiments, and Steven Kern for statistical support. Strain Bp82 was graciously provided to us Prof. Herbert Schweizer (Colorado State University). Support was provided by the following Resource Centers of The Rockefeller University: Proteomics (mass spectrometry) and High-Throughput and Spectroscopy (NMR facilities). NR 35 TC 9 Z9 9 U1 4 U2 25 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0002-7863 J9 J AM CHEM SOC JI J. Am. Chem. Soc. PD JUL 2 PY 2014 VL 136 IS 26 BP 9484 EP 9490 DI 10.1021/ja504617n PG 7 WC Chemistry, Multidisciplinary SC Chemistry GA AK8QI UT WOS:000338692700036 PM 24884988 ER PT J AU Allison, PG Rodriguez, RI Moser, RD Williams, BA Poda, AR Seiter, JM Lafferty, BJ Kennedy, AJ Chandler, MQ AF Allison, Paul G. Rodriguez, Rogie I. Moser, Robert D. Williams, Brett A. Poda, Aimee R. Seiter, Jennifer M. Lafferty, Brandon J. Kennedy, Alan J. Chandler, Mei Q. TI Characterization Of Multi-layered Fish Scales (Atractosteus spatula) Using Nanoindentation, X-ray CT, FTIR, and SEM SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS LA English DT Article DE Bioengineering; Issue 89; Atractosteus spatula; structure-property relation; nanoindentation; scan electron microscopy; X-ray computed tomography; Fourier transform infrared (FTIR) spectroscopy ID MECHANICAL-PROPERTIES; CONCRETE; DESIGN AB The hierarchical architecture of protective biological materials such as mineralized fish scales, gastropod shells, ram's horn, antlers, and turtle shells provides unique design principles with potentials for guiding the design of protective materials and systems in the future. Understanding the structure-property relationships for these material systems at the microscale and nanoscale where failure initiates is essential. Currently, experimental techniques such as nanoindentation, X-ray CT, and SEM provide researchers with a way to correlate the mechanical behavior with hierarchical microstructures of these material systems. However, a well-defined standard procedure for specimen preparation of mineralized biomaterials is not currently available. In this study, the methods for probing spatially correlated chemical, structural, and mechanical properties of the multilayered scale of A. spatula using nanoindentation, FTIR, SEM, with energy-dispersive X-ray (EDX) microanalysis, and X-ray CT are presented. C1 [Allison, Paul G.; Moser, Robert D.; Williams, Brett A.; Chandler, Mei Q.] US Army, Geotech & Struct Lab, Engn Res & Dev Ctr, Washington, DC 20310 USA. [Rodriguez, Rogie I.] Univ Alabama, Dept Mech Engn, Tuscaloosa, AL 35487 USA. [Poda, Aimee R.; Seiter, Jennifer M.; Lafferty, Brandon J.; Kennedy, Alan J.] US Army, Environm Lab, Engn Res & Dev Ctr, Washington, DC 20310 USA. RP Allison, PG (reprint author), US Army, Geotech & Struct Lab, Engn Res & Dev Ctr, Washington, DC 20310 USA. EM paul.g.allison@usace.army.mil RI Poda, Aimee/K-1905-2012 FU US Army ERDC Military Engineering 6.1 Basic Research Program; ERDC Center for Directed Research Program FX The Authors would like to acknowledge the financial support for this work provided by the US Army ERDC Military Engineering 6.1 Basic Research Program and the ERDC Center for Directed Research Program. The Authors would also like to thank the staff and facilities of the ERDC Geotechnical and Structural Laboratory's Concrete and Materials Branch for supporting the experimental work. Permission to publish was granted by the Director, Geotechnical & Structures Laboratory. NR 18 TC 1 Z9 1 U1 3 U2 11 PU JOURNAL OF VISUALIZED EXPERIMENTS PI CAMBRIDGE PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA SN 1940-087X J9 JOVE-J VIS EXP JI J. Vis. Exp. PD JUL PY 2014 IS 89 AR e51535 DI 10.3791/51535 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CB0DR UT WOS:000349296100035 ER PT J AU Goldman, GH AF Goldman, Geoffrey H. TI Blind Focusing Algorithm Applied to the Acoustic Signal of a Maneuvering Rotorcraft SO IEEE TRANSACTIONS ON AEROSPACE AND ELECTRONIC SYSTEMS LA English DT Article ID MOTION COMPENSATION; TRACKING; LOCALIZATION; AIRCRAFT; SENSOR AB An algorithm was developed and tested to blindly focus the acoustic spectra of a rotorcraft that was blurred by time-varying Doppler shifts and other effects such atmospheric distortion. First, the fundamental frequency generated by the main rotor blades of a rotorcraft was tracked using a fixed-lag smoother. Then, the frequency estimates were used to resample the data using interpolation. Next, the motion-compensated data were further focused using a technique based upon the phase gradient autofocus (PGA) algorithm. The performance of the algorithm was evaluated by analyzing the increase in the amplitude of the harmonics due to focusing the data. For most of the data, the algorithm focused the harmonics between approximately 10-90 Hz to within 1-2 dB of an estimated upper bound (UB) obtained from conservation of energy and estimates of the Doppler shift. In addition, the algorithm was able to separate two closely spaced frequencies in the spectra of the rotorcraft. The algorithm developed can be used to preprocess data for classification, nulling, and tracking algorithms. C1 US Army, Res Lab, Acoust & Electromagnet Sensing Branch, Adelphi, MD 20783 USA. RP Goldman, GH (reprint author), US Army, Res Lab, Acoust & Electromagnet Sensing Branch, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM geoffrey.h.goldman.civ@mail.mil NR 31 TC 0 Z9 0 U1 1 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9251 EI 1557-9603 J9 IEEE T AERO ELEC SYS JI IEEE Trans. Aerosp. Electron. Syst. PD JUL PY 2014 VL 50 IS 3 BP 1715 EP 1725 DI 10.1109/TAES.2014.130321 PG 11 WC Engineering, Aerospace; Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA AX2RF UT WOS:000346791100011 ER PT J AU Jensen, JO Jensen, JL Chue, CC AF Jensen, James O. Jensen, Janet L. Chue, Calvin C. TI Nanoengineered Bioplatforms Based on DNA Origami SO PROCEEDINGS OF THE IEEE LA English DT Editorial Material ID NANOSTRUCTURES C1 [Jensen, James O.; Jensen, Janet L.; Chue, Calvin C.] US Army, Res & Technol Directorate, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Jensen, JO (reprint author), US Army, Res & Technol Directorate, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. NR 5 TC 1 Z9 1 U1 3 U2 15 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9219 EI 1558-2256 J9 P IEEE JI Proc. IEEE PD JUL PY 2014 VL 102 IS 7 SI SI BP 1046 EP 1049 DI 10.1109/JPROC.2014.2326808 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA AK1PQ UT WOS:000338187700001 ER PT J AU Checkai, R Van Genderen, E Sousa, JP Stephenson, G Smolders, E AF Checkai, Ron Van Genderen, Eric Sousa, Jose Paulo Stephenson, Gladys Smolders, Erik TI Deriving Site-Specific Clean-Up Criteria to Protect Ecological Receptors (Plants and Soil Invertebrates) Exposed to Metal or Metalloid Soil Contaminants via the Direct Contact Exposure Pathway SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Article ID NOEC TOXICITY DATA; RISK APPROACH; MOLYBDENUM; ACCOUNT; VALUES; COPPER; LIMITS; ZINC AB Soil contaminant concentration limits for the protection of terrestrial plants and soil invertebrates are commonly based on thresholds derived using data from laboratory ecotoxicity tests. A comprehensive assessment has been made for the derivation of ecological soil screening levels (Eco-SSL) in the United States; however, these limits are conservative because of their focus on high bioavailability scenarios. Here, we explain and evaluate approaches to soil limit derivation taken by 4 jurisdictions, 2 of which allow for correction of data for factors affecting bioavailability among soils, and between spiked and field-contaminated soils (Registration Evaluation Authorisation and Restriction of Chemicals [REACH] Regulation, European Union [EU], and the National Environment Protection Council [NEPC], Australia). Scientifically advanced features from these methods have been integrated into a newly developed method for deriving soil clean-up values (SCVs) within the context of site-specific baseline ecological risk assessment. Resulting site-specific SCVs that account for bioavailability may permit a greater residual concentration in soil when compared to generic screening limit concentrations (e.g., Eco-SSL), while still affording acceptable protection. Two choices for selecting the level of protection are compared (i.e., allowing higher effect levels per species, or allowing a higher percentile of species that are potentially unprotected). Implementation of this new method is presented for the jurisdiction of the United States, with a focus on metal and metalloid contaminants; however, the new method can be used in any jurisdiction. A case study for molybdate shows the large effect of bioavailability corrections and smaller effects of protection level choices when deriving SCVs. (C) 2014 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of SETAC. RP Checkai, R (reprint author), US Army Edgewood Chem Biol Ctr, Environm Toxicol Branch, Aberdeen Proving Ground, MD 21010 USA. EM Ronald.T.Checkai.Civ@mail.mil RI Sousa, Jose Paulo/H-5407-2011 OI Sousa, Jose Paulo/0000-0001-8045-4296 NR 34 TC 6 Z9 6 U1 3 U2 11 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD JUL PY 2014 VL 10 IS 3 BP 346 EP 357 DI 10.1002/ieam.1528 PG 12 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA AK0VG UT WOS:000338133500006 PM 24470189 ER PT J AU Kuperman, RG Siciliano, SD Rombke, J Oorts, K AF Kuperman, Roman G. Siciliano, Steven D. Roembke, Joerg Oorts, Koen TI Deriving Site-Specific Soil Clean-Up Values for Metals and Metalloids: Rationale for Including Protection of Soil Microbial Processes SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Article AB Although it is widely recognized that microorganisms are essential for sustaining soil fertility, structure, nutrient cycling, groundwater purification, and other soil functions, soil microbial toxicity data were excluded from the derivation of Ecological Soil Screening Levels (Eco-SSL) in the United States. Among the reasons for such exclusion were claims that microbial toxicity tests were too difficult to interpret because of the high variability of microbial responses, uncertainty regarding the relevance of the various endpoints, and functional redundancy. Since the release of the first draft of the Eco-SSL Guidance document by the US Environmental Protection Agency in 2003, soil microbial toxicity testing and its use in ecological risk assessments have substantially improved. A wide range of standardized and nonstandardized methods became available for testing chemical toxicity to microbial functions in soil. Regulatory frameworks in the European Union and Australia have successfully incorporated microbial toxicity data into the derivation of soil threshold concentrations for ecological risk assessments. This article provides the 3-part rationale for including soil microbial processes in the development of soil clean-up values (SCVs): 1) presenting a brief overview of relevant test methods for assessing microbial functions in soil, 2) examining data sets for Cu, Ni, Zn, and Mo that incorporated soil microbial toxicity data into regulatory frameworks, and 3) offering recommendations on how to integrate the best available science into the method development for deriving site-specific SCVs that account for bioavailability of metals and metalloids in soil. Although the primary focus of this article is on the development of the approach for deriving SCVs for metals and metalloids in the United States, the recommendations provided in this article may also be applicable in other jurisdictions that aim at developing ecological soil threshold values for protection of microbial processes in contaminated soils. (C) 2014 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of SETAC. RP Kuperman, RG (reprint author), US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM roman.g.kuperman.civ@mail.mil OI Kuperman, Roman/0000-0001-5344-1633; Rombke, Jorg/0000-0003-1341-634X; Oorts, Koen/0000-0002-8328-3581 NR 46 TC 5 Z9 5 U1 1 U2 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD JUL PY 2014 VL 10 IS 3 BP 388 EP 400 DI 10.1002/ieam.1513 PG 13 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA AK0VG UT WOS:000338133500009 PM 24376192 ER PT J AU Wambeke, BW Liu, M Hsiang, SM AF Wambeke, Brad W. Liu, Min Hsiang, Simon M. TI Task Variation and the Social Network of Construction Trades SO JOURNAL OF MANAGEMENT IN ENGINEERING LA English DT Article DE Variation; Risk assessment; Social network; Performance; Construction ID MULTIATTRIBUTE UTILITY MEASUREMENT; PRODUCTIVITY; MANAGEMENT AB Construction projects can be complex and managers are faced with the challenge of managing multiple trades working on a large number of interdependent tasks. When one trade or task experiences variation, defined as the time difference between what was planned and what occurred for this research, additional trades or tasks can be impacted. This can result in a disrupted project schedule and reduced productivity. A case study involving a general contractor (GC) building a $50 million, 150,000 sq ft data collection center was conducted. Both starting time and task duration variation data was collected on approximately 1,200 tasks performed by over 40 trades. A risk assessment matrix was used to determine which causes of variation posed the greatest risk to project performance. Pajek, a social network analysis software, was used to illustrate the organizational structure of the key trades throughout the project based on spatial proximity. It was found that material delivery and not having prerequisite work completed were the top two causes of starting time variation and overcommitment was the top cause of task duration variation. The study couples the variation analysis with the associated social network of trades to create a decision making system, thus, the paper's main contribution to the body of knowledge. The results of this research are repeatable and can be useful for managers in improving project performance. (C) 2014 American Society of Civil Engineers. C1 [Wambeke, Brad W.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. [Liu, Min] N Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA. [Hsiang, Simon M.] Texas Tech Univ, Lubbock, TX 79409 USA. RP Liu, M (reprint author), N Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA. EM bwwambek@ncsu.edu; min_liu@ncsu.edu; simon.hsiang@ttu.edu NR 26 TC 2 Z9 2 U1 3 U2 16 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0742-597X EI 1943-5479 J9 J MANAGE ENG JI J. Manage. Eng. PD JUL PY 2014 VL 30 IS 4 AR 05014008 DI 10.1061/(ASCE)ME.1943-5479.0000219 PG 8 WC Engineering, Industrial; Engineering, Civil SC Engineering GA AW2PT UT WOS:000346131500011 ER PT J AU Wright, ER Cho, K Hastak, M AF Wright, Erik R. Cho, Kyuman Hastak, Makarand TI Assessment of Critical Construction Engineering and Management Aspects of Nuclear Power Projects SO JOURNAL OF MANAGEMENT IN ENGINEERING LA English DT Article DE Nuclear power construction; Exploratory factor analysis AB Thirty years ago when the last nuclear power plant was ordered in the United States, many nuclear projects were suffering from large cost and schedule overruns, which were often caused by poor project management practices and a general lack of nuclear experience. This research aims at illustrating (1) critical project management areas and tasks with respect to a nuclear project life cycle; and (2) critical aspects associated with the successful nuclear construction projects. As a result, this research identified the relative priorities of six phases of a modified engineering procurement construction (EPC) project life cycle with respect to nuclear construction projects based on the results of descriptive statistics. Subsequently, 76 tasks embedded in the modified life cycle were condensed into 12 critical aspects of nuclear construction projects using an exploratory factor analysis method. Consequently, this research is aimed at establishing the basis for the development of a modern nuclear construction body of knowledge and the education of the future experienced cadre of nuclear construction professionals. (C) 2014 American Society of Civil Engineers. C1 [Wright, Erik R.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. [Cho, Kyuman] Chosun Univ, Sch Architecture, Kwangju 501759, South Korea. [Hastak, Makarand] Purdue Univ, Div Construct Engn & Management, W Lafayette, IN 47907 USA. RP Cho, K (reprint author), Chosun Univ, Sch Architecture, Kwangju 501759, South Korea. EM erik.wright@usma.edu; cho129@chosun.ac.kr; hastak@purdue.edu NR 16 TC 1 Z9 1 U1 3 U2 14 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0742-597X EI 1943-5479 J9 J MANAGE ENG JI J. Manage. Eng. PD JUL PY 2014 VL 30 IS 4 AR 04014016 DI 10.1061/(ASCE)ME.1943-5479.0000286 PG 11 WC Engineering, Industrial; Engineering, Civil SC Engineering GA AW2PT UT WOS:000346131500006 ER PT J AU Pilia, M McDaniel, JS Guda, T Chen, XK Rhoads, RP Allen, RE Corona, BT Rathbone, CR AF Pilia, M. McDaniel, J. S. Guda, T. Chen, X. K. Rhoads, R. P. Allen, R. E. Corona, B. T. Rathbone, C. R. TI TRANSPLANTATION AND PERFUSION OF MICROVASCULAR FRAGMENTS IN A RODENT MODEL OF VOLUMETRIC MUSCLE LOSS INJURY SO EUROPEAN CELLS & MATERIALS LA English DT Article DE Microvessel; volumetric muscle loss; skeletal muscle; stem cell; angiogenesis ID HUMAN ADIPOSE-TISSUE; SKELETAL-MUSCLE; STEM-CELLS; SATELLITE CELLS; ENDOTHELIAL-CELLS; IN-VITRO; ANGIOGENESIS; REGENERATION; THERAPY; VASCULARIZATION AB Few clinical options are available for the treatment of volumetric muscle loss (VML). An important consideration that needs to be addressed for the development of treatments for these injuries is the establishment of a vascular supply sufficient to support skeletal muscle regeneration. The objective of the current study was to evaluate the potential for microvascular fragments (MVFs) harvested from adipose tissue to support tissue perfusion for VML. Tibialis anterior muscle defects in rats were replaced with constructs that were created on the day of surgery containing either (1) collagen only (COL), (2) freshly isolated microvascular fragments in collagen (MVF), or (3) adipose tissue derived stem cells (ASCs) in collagen. Muscles were harvested 7 and 14 days after surgery. Defects treated with MVFs had a vessel density higher than the other groups at both 7 and 14 days, and those treated with ASCs had a higher vessel density than COL by day 14 (p < 0.05). Perfused vessels were observed in both the ASC and MVF treated defects at day 14, as well as at day 7 in the MVF. This study supports the use of MVFs as a platform to improve tissue perfusion to treat large VML defects. The use of freshly isolated MVFs on the day of surgery supports their clinical use and application. C1 [Pilia, M.; McDaniel, J. S.; Guda, T.; Chen, X. K.; Corona, B. T.; Rathbone, C. R.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Guda, T.] Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX USA. [Rhoads, R. P.] Virginia Tech, Dept Anim & Poultry Sci, Blacksburg, VA USA. [Rhoads, R. P.; Allen, R. E.] Univ Arizona, Dept Anim Sci, Tucson, AZ 85721 USA. RP Rathbone, CR (reprint author), 3698 Chambers Pass BLDG 3611 JBSA, Ft Sam Houston, TX 78234 USA. EM christopher.r.rathbone.civ@mail.mil RI Rhoads, Robert/F-2861-2016 OI Rhoads, Robert/0000-0002-5205-5834 FU U.S. Army Medical Research and Materiel Command of the Department of Defense FX This study was supported by the U.S. Army Medical Research and Materiel Command of the Department of Defense. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or reflecting the views of the Department of Defense or US government. This research was performed while the author (M. P) held a National Research Council Research Associateship Award at the United States Army Institute of Surgical Research. The authors would like to express their sincere gratitude to Monica Jalomo, Janet Roe, and Stephanie Roth for their invaluable technical assistance. NR 38 TC 13 Z9 13 U1 0 U2 3 PU AO RESEARCH INSTITUTE DAVOS-ARI PI DAVOS PA CLAVADELERSTRASSE 8, DAVOS, CH 7270, SWITZERLAND SN 1473-2262 J9 EUR CELLS MATER JI Eur. Cells Mater. PD JUL-DEC PY 2014 VL 28 BP 11 EP 24 PG 14 WC Cell & Tissue Engineering; Engineering, Biomedical; Materials Science, Biomaterials SC Cell Biology; Engineering; Materials Science GA AU4EQ UT WOS:000345562600002 PM 25017641 ER PT J AU Paullin, C Legree, PJ Sinclair, AL Moriarty, KO Campbell, RC Kilcullen, RN AF Paullin, Cheryl Legree, Peter J. Sinclair, Andrea L. Moriarty, Karen O. Campbell, Roy C. Kilcullen, Robert N. TI Delineating Officer Performance and Its Determinants SO MILITARY PSYCHOLOGY LA English DT Article DE job analysis; job duties; Army officer; leader performance; leader tasks ID VOLUNTARY TURNOVER; JOB EMBEDDEDNESS; LEADERSHIP AB The U.S. Army faces complex challenges in building and sustaining its officer force. It needs to identify and develop individuals who can adapt to many different mission types and to the various environments in which the Army operates, develop the strategic and tactical leadership skills necessary to perform effectively in higher ranks, and embrace the Army's warrior ethos. To create a performance-based foundation for accessing, assigning, training, and retaining officers, we conducted a job analysis study. Using Army doctrine, protocol, training manuals, and input from a number of Army officers, we identified 46 leader and management major duties that officers must perform with a high level of competence. The list is intended to be relevant for all Army officer positions and levels up to lieutenant colonel, though the relative importance of and time spent on specific duties varies by level, position, branch, and mission. We also identified 55 stable individual difference attributes and attitudes that underlie the determinants of officer performance and retention. We framed our study according to 2 models of job performance, 1 specifying the determinants of job performance and the other specifying the major components of job performance. The integrated models provide a theoretical basis for designing personnel systems or interventions to impact specific components of officer performance and for predicting their likely outcomes. C1 [Paullin, Cheryl; Sinclair, Andrea L.; Moriarty, Karen O.; Campbell, Roy C.] Human Resources Res Org, Alexandria, VA USA. [Legree, Peter J.; Kilcullen, Robert N.] US Army Res Inst Behav & Social Sci, Ft Belvoir, VA USA. RP Paullin, C (reprint author), HumRRO, 100 Washington Ave S,Suite 1660, Minneapolis, MN 55401 USA. EM cpaullin@humrro.org NR 74 TC 2 Z9 2 U1 1 U2 5 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0899-5605 EI 1532-7876 J9 MIL PSYCHOL JI Milit. Psychol. PD JUL PY 2014 VL 26 IS 4 SI SI BP 259 EP 277 DI 10.1037/mil0000051 PG 19 WC Psychology, Multidisciplinary SC Psychology GA AU2MR UT WOS:000345453100002 ER PT J AU Wolters, HMK O'Shea, PG Ford, LA Fleisher, MS Adeniyi, MA Conzelman, CE Webster, RJ AF Wolters, Heather M. K. O'Shea, Patrick Gavan Ford, Laura A. Fleisher, Matthew S. Adeniyi, Mary A. Conzelman, Clair E. Webster, Russell J. TI Identifying and Training Brigade Command Competencies SO MILITARY PSYCHOLOGY LA English DT Article DE brigade command; competency modeling; training competency clusters; leadership; training methods ID LEADERSHIP AB This research identified competencies required to command a brigade. Interviews and surveys of military personnel provided a multisource perspective of brigade command competencies, including the proficiency level needed for each competency. Thirty-nine competencies were identified and categorized into 4 training-oriented clusters: leadership skills, operational skills, personal capabilities, and knowledge base. Participants reported their preferred methods to develop the competencies within each cluster. The competencies can be used to assess training effectiveness and to identify potential training gaps. Additionally, the model has utility outside of the military, as it describes a framework for leaders who must bridge the gap between organizational and strategic leadership. C1 [Wolters, Heather M. K.] US Army Res Inst Behav & Social Sci, Ft Belvoir, VA USA. [O'Shea, Patrick Gavan; Ford, Laura A.; Fleisher, Matthew S.; Adeniyi, Mary A.; Conzelman, Clair E.] Human Resources Res Org, Louisville, KY USA. [Webster, Russell J.] Consortium Res Fellows Program, Alexandria, VA USA. RP Wolters, HMK (reprint author), US Army Res Inst, 6000 6th St, Ft Belvoir, VA 22060 USA. EM heather.wolters@us.army.mil NR 26 TC 3 Z9 3 U1 1 U2 9 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0899-5605 EI 1532-7876 J9 MIL PSYCHOL JI Milit. Psychol. PD JUL PY 2014 VL 26 IS 4 SI SI BP 278 EP 291 DI 10.1037/mil0000052 PG 14 WC Psychology, Multidisciplinary SC Psychology GA AU2MR UT WOS:000345453100003 ER PT J AU Legree, PJ Kilcullen, RN Putka, DJ Wasko, LE AF Legree, Peter J. Kilcullen, Robert N. Putka, Dan J. Wasko, Laurie E. TI Identifying the Leaders of Tomorrow: Validating Predictors of Leader Performance SO MILITARY PSYCHOLOGY LA English DT Article DE ROTC; CBEF; TAPAS; leader potential AB The Reserve Officers' Training Corps (ROTC) is the largest commissioning source for the U.S. Army. Although some ROTC cadets receive no scholarship assistance, other cadets receive 2-, 3-, or 4-year ROTC scholarships in exchange for incurring a military service obligation after college graduation. The Army is particularly interested in awarding 4-year scholarships to individuals who are likely to excel in ROTC and become Army leaders. This research examined how well measures of temperament, work values, and leadership knowledge predicted the performance 4-year scholarship winners in various phases of ROTC, including their ranking on a national Order of Merit Listing in their senior year of college. Measures of temperament, work values, and leader knowledge strongly predicted each of the ROTC performance metrics. C1 [Legree, Peter J.; Kilcullen, Robert N.] US Army Res Inst Behav & Social Sci, Ft Belvoir, VA 22026 USA. [Putka, Dan J.; Wasko, Laurie E.] Human Resources Res Org, Alexandria, VA USA. RP Legree, PJ (reprint author), US Army Res Inst Behav & Social Sci, 6000 6th St,Bldg 1464 Mail Stop 5610, Ft Belvoir, VA 22026 USA. EM peter.j.legree.civ@mail.mil NR 20 TC 4 Z9 4 U1 3 U2 5 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0899-5605 EI 1532-7876 J9 MIL PSYCHOL JI Milit. Psychol. PD JUL PY 2014 VL 26 IS 4 SI SI BP 292 EP 309 DI 10.1037/mil0000054 PG 18 WC Psychology, Multidisciplinary SC Psychology GA AU2MR UT WOS:000345453100004 ER PT J AU Allen, MT Bynum, BH Oliver, JT Russell, TL Young, MC Babin, NE AF Allen, Matthew T. Bynum, Bethany H. Oliver, Joy T. Russell, Teresa L. Young, Mark C. Babin, Nehama E. TI Predicting Leadership Performance and Potential in the US Army Officer Candidate School (OCS) SO MILITARY PSYCHOLOGY LA English DT Article DE Officer Candidate School; leadership; implicit leadership; general cognitive ability; personality ID ORGANIZATIONAL COMMITMENT; MISSING DATA; CONSTRUCT-VALIDITY; PERSONALITY; ANTECEDENTS; CONSEQUENCES; METAANALYSIS; MOTIVATION; KNOWLEDGE; SETTINGS AB The purpose of this article was to determine proximal and distal antecedents of leadership in the U.S. Army's Officer Candidate School (OCS). A model composed of motivation to lead, leadership self-efficacy, implicit leadership, organizational commitment, general cognitive ability, and personality was proposed. Results from a longitudinal examination of 1,232 officer candidates suggest partial support for the model, and limited evidence for enlisted experience as a moderator. Candidate personality (partially mediated by interest in leadership and leadership self-efficacy) best predicted leadership performance during OCS and peer ratings of leadership potential. Implications for OCS selection and models of leadership performance are discussed. C1 [Allen, Matthew T.; Bynum, Bethany H.; Oliver, Joy T.; Russell, Teresa L.] Human Resources Res Org, Alexandria, VA USA. [Young, Mark C.; Babin, Nehama E.] US Army Res Inst Behav & Social Sci, Ft Belvoir, VA USA. RP Allen, MT (reprint author), Dept Def, ATTN MTD3 Suite 6665,9800 Savage Rd, Ft George G Meade, MD 20755 USA. EM matt.allen250@gmail.com NR 57 TC 2 Z9 2 U1 5 U2 15 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0899-5605 EI 1532-7876 J9 MIL PSYCHOL JI Milit. Psychol. PD JUL PY 2014 VL 26 IS 4 SI SI BP 310 EP 326 DI 10.1037/mil0000056 PG 17 WC Psychology, Multidisciplinary SC Psychology GA AU2MR UT WOS:000345453100005 ER PT J AU Kelly, DR Matthews, MD Bartone, PT AF Kelly, Dennis R. Matthews, Michael D. Bartone, Paul T. TI Grit and Hardiness as Predictors of Performance Among West Point Cadets SO MILITARY PSYCHOLOGY LA English DT Article DE grit; hardiness; leadership; noncognitive ID ACADEMY AB The U.S. Military Academy has historically used an academically weighted composite of aptitude, leadership, and physical ability indices for selection of candidates and to predict their performance at the Academy. Researchers at West Point have begun to investigate the incremental contribution of a variety of less traditional nonaptitude or noncognitive factors in predicting performance. Particular focus has centered on hardiness and grit because they have been shown to predict persistence through Cadet Basic Training (CBT) and achievement in the first year at the Academy. In the current investigation, we further examined the predictive validity of grit and hardiness, and their subfacets, on retention and performance through the full 4-year West Point program with data from 1,558 cadets, comprising the West Point classes of 2009 and 2010. Results of regression analyses indicate that whereas grit interest and hardiness commitment were the sole predictors of attrition from CBT, only grit effort predicted persistence across the remaining 4 year period. College Entrance Exam Rank (CEER), a traditional measure of academic success, did not predict persistence. In terms of performance, grit interest, and hardiness control added to CEER in the prediction of 4-year academic performance. Although CEER continued to be the best predictor of military performance, grit effort and hardiness commitment were also important contributors. Finally, grit effort also added to the Athletic Activities Score and CEER in predicting physical performance. These results indicate that the noncognitive factors grit and hardiness are important predictors of success in military officer candidates. We discuss the implication of our findings for selection and prediction of performance of within military environments. C1 [Kelly, Dennis R.; Matthews, Michael D.] US Mil Acad, West Point, NY 10996 USA. [Bartone, Paul T.] Natl Def Univ, Ctr Technol & Natl Secur Policy, Washington, DC 20319 USA. RP Kelly, DR (reprint author), US Mil Acad, Taylor Hall,5th Floor, West Point, NY 10996 USA. EM dennis.kelly@usma.edu OI Bartone, Paul/0000-0002-5767-0086 NR 27 TC 8 Z9 8 U1 5 U2 28 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0899-5605 EI 1532-7876 J9 MIL PSYCHOL JI Milit. Psychol. PD JUL PY 2014 VL 26 IS 4 SI SI BP 327 EP 342 DI 10.1037/mil0000050 PG 16 WC Psychology, Multidisciplinary SC Psychology GA AU2MR UT WOS:000345453100006 ER PT J AU Bousman, WG AF Bousman, William G. TI Rotorcraft Airloads Measurements: Extraordinary Costs, Extraordinary Benefits The 31st Alexander Nikolsky Honorary Lecture SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article ID PREDICTION; FLIGHT; PRESSURE; ROTORS; UH-60A; CFD AB The first airloads measurements were made in the 1950s at NACA Langley on a 15.3-ft-diameter model rotor, stimulated by the invention of miniaturized pressure transducers. The inability to predict higher harmonic loads in those early years led the U.S. Army to fund airloads measurements on the CH-34 and the UH-1A aircraft. Nine additional comprehensive airloads tests have been done since that early work, including the recent test of an instrumented UH-60A rotor in the 40- x 80-ft Wind Tunnel at NASA Ames. This historical narrative discusses the 12 airloads tests and how the results were integrated with analytical efforts. The recent history of the UH-60A Airloads Workshops is presented, and it is shown that new developments in analytical methods have transformed our capability to predict airloads that are critical for design. C1 [Bousman, William G.] US Army Aeroflightdynam Directorate, Moffett Field, CA USA. EM barlowi@earthlink.net NR 125 TC 1 Z9 1 U1 0 U2 6 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 EI 2161-6027 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD JUL PY 2014 VL 59 IS 3 AR 031001 DI 10.4050/JAHS.59.031001 PG 30 WC Engineering, Aerospace SC Engineering GA AS6HX UT WOS:000344365900001 ER PT J AU Smith, TJ White, A Hadden, L Young, AJ Marriott, BP AF Smith, Tracey J. White, Alan Hadden, Louise Young, Andrew J. Marriott, Bernadette P. TI Associations between Mental Health Disorders and Body Mass Index among Military Personnel SO AMERICAN JOURNAL OF HEALTH BEHAVIOR LA English DT Article DE BMI; mental health ID POSTTRAUMATIC-STRESS-DISORDER; NUTRITION EXAMINATION SURVEY; SELF-REPORTED HEIGHT; 3RD NATIONAL-HEALTH; GENERAL-POPULATION; PSYCHOLOGICAL DISTRESS; US ADULTS; OBESITY; DEPRESSION; SUICIDE AB Objective: To determine if overweight or obesity is associated with mental health disorder (MHD) symptoms among military personnel Methods: Secondary analysis using the 2005 Department of Defense Health Related Behaviors Survey (N = 15,195). Standard Body Mass Index (BMI) categories were used to classify participants' body composition. Results: For women, obesity was associated with symptoms of serious psychological distress (SPD), post-traumatic stress disorder, and depression. For men, obesity and overweight was associated with symptoms of generalized anxiety disorder and SPD, respectively. Self-reported high personal stress was the strongest predictor of MHD symptoms and suicide attempts. Conclusion: Self-reported stress was a stronger predictor of MHD symptoms than BMI. There is potential value in screening personnel for personal stress as a MHD risk factor. C1 [Smith, Tracey J.; Young, Andrew J.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. [White, Alan] Abt Associates Inc, Durham, NC USA. [Hadden, Louise] Abt Associates Inc, Cambridge, MA USA. [Marriott, Bernadette P.] Med Univ S Carolina, Dept Med, Div Gastroenterol, Charleston, SC 29425 USA. RP Smith, TJ (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. EM tracey.smith10.civ@mail.mil NR 50 TC 5 Z9 5 U1 4 U2 11 PU PNG PUBLICATIONS PI OAK RIDGE PA 2205-K OAK RIDGE RD, #115, OAK RIDGE, NC 27310 USA SN 1945-7359 J9 AM J HEALTH BEHAV JI Am. J. Health Behav. PD JUL PY 2014 VL 38 IS 4 BP 529 EP 540 DI 10.5993/AJHB.38.4.6 PG 12 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AS1JC UT WOS:000344036400006 PM 24636115 ER PT J AU Austin, KG Travis, J Pace, G Lieberman, HR AF Austin, Krista G. Travis, John Pace, Gerry Lieberman, Harris R. TI Analysis of 1,3 dimethylamylamine concentrations in Geraniaceae, geranium oil and dietary supplements SO DRUG TESTING AND ANALYSIS LA English DT Article DE DMAA; pelargonium; stimulant; synthetic; DSHEA; ephedra ID BLOOD-PRESSURE; BITTER ORANGE; HEART-RATE; PELARGONIUM; 1,3-DIMETHYLAMYLAMINE; EXTRACTS; CAFFEINE; HEALTHY; WEIGHT; SAFETY AB 1,3-Dimethylamylamine (DMAA) is a sympathomimetic compound currently incorporated into some dietary supplements. Significant controversy exists regarding the 'natural' origin of DMAA, as claimed by manufacturers of supplements. Manufacturers often refer to its presence by the name Geranamine (R) implying that DMAA is found in the plant species Geranium and Pelargonium known collectively as Geraniaceae. This study determined whether DMAA is present in the plant species, Geranium and Pelargonium. In addition, concentrations of DMAA in popular dietary supplements and commercial Geranium and Pelargonium oils were assessed. One Pelargonium cultivar, one Geranium cultivar, three essential oils from Pelargonium or Geranium, raw DMAA powder, and seven dietary supplements (DS) sold as finished products and labelled as containing DMAA, or one of its synonyms, were analyzed for the presence of DMAA by ultra performance liquid chromatography tandemmass spectrometry (UPLC-MS/MS). No measurable levels of DMAA in Geranium, Pelargonium or essential oils at a detection limit of 1-2 ng/g were present. UPLC/MS/MS analysis confirmed the presence of DMAA in spiked plant and oil samples, all seven DS products, and raw DMAA powder. Concentrations (weight%) of DMAA provided in DS ranged from 0.11% to 673%. This study indicates DMAA contained in DS is of a synthetic origin and is not present in the plant species Geranium and Pelargonium; thus the 'natural' origin and use of DMAA as an ingredient in DS is not substantiated. Copyright (C) 2013 John Wiley & Sons, Ltd. C1 [Austin, Krista G.; Lieberman, Harris R.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. [Austin, Krista G.] Oak Ridge Inst Sci & Educ, Belcamp, MD 21017 USA. [Travis, John; Pace, Gerry] NSF Int, Ann Arbor, MI 48105 USA. RP Austin, KG (reprint author), US Army, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. EM krista.g.austin.ctr@mail.mil FU US Army Medical Research and Materiel Command (USAMRMC); Department of Defense Center Alliance for Dietary Supplement Research FX This work was supported by the US Army Medical Research and Materiel Command (USAMRMC) and the Department of Defense Center Alliance for Dietary Supplement Research. The opinions contained herein are the private views of the author and are not to be construed as official or as reflecting the views of the Army or the Department of Defense. Citations of commercial organizations and trade names in this report do not constitute an official Department of the Army endorsement or approval of the products or services of these organizations. Approved for public release; distribution is unlimited. NR 30 TC 11 Z9 11 U1 4 U2 14 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1942-7603 EI 1942-7611 J9 DRUG TEST ANAL JI Drug Test. Anal. PD JUL-AUG PY 2014 VL 6 IS 7-8 SI SI BP 797 EP 804 DI 10.1002/dta.1491 PG 8 WC Biochemical Research Methods; Chemistry, Analytical; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy GA AQ6YR UT WOS:000342960300022 PM 23704033 ER PT J AU Urben, HA AF Urben, Heidi A. TI Wearing Politics on Their Sleeves? Levels of Political Activism of Active Duty Army Officers SO ARMED FORCES & SOCIETY LA English DT Article ID MILITARY C1 US Mil Acad, Dept Social Sci, West Point, NY 10996 USA. RP Urben, HA (reprint author), US Mil Acad, Dept Social Sci, 607 Cullum Rd, West Point, NY 10996 USA. EM Heidi.urben@usma.edu NR 34 TC 2 Z9 2 U1 0 U2 2 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0095-327X EI 1556-0848 J9 ARMED FORCES SOC JI Armed Forces Soc. PD JUL PY 2014 VL 40 IS 3 BP 568 EP 591 DI 10.1177/0095327X12467774 PG 24 WC Political Science; Sociology SC Government & Law; Sociology GA AQ4TN UT WOS:000342792700009 ER PT J AU Dempsey, J AF Dempsey, Jason TI Bleeding Talent How the US Military Mismanages Great Leaders and Why It's Time for a Revolution SO ARMED FORCES & SOCIETY LA English DT Book Review C1 [Dempsey, Jason] US Army, Washington, DC 20301 USA. RP Dempsey, J (reprint author), US Army, Washington, DC 20301 USA. NR 5 TC 0 Z9 0 U1 0 U2 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0095-327X EI 1556-0848 J9 ARMED FORCES SOC JI Armed Forces Soc. PD JUL PY 2014 VL 40 IS 3 BP 592 EP 595 PG 4 WC Political Science; Sociology SC Government & Law; Sociology GA AQ4TN UT WOS:000342792700010 ER PT J AU Chen, YJ Lee, J Puryear, M Wong, RKH Lake, JM Maydonovitch, CL Belle, L Moawad, FJ AF Chen, Yen-Ju Lee, Jennifer Puryear, Magaly Wong, Roy K. H. Lake, Jason M. Maydonovitch, Corrine L. Belle, Lavern Moawad, Fouad J. TI A Randomized Controlled Study Comparing Room Air With Carbon Dioxide for Abdominal Pain, Distention, and Recovery Time in Patients Undergoing Colonoscopy SO GASTROENTEROLOGY NURSING LA English DT Article ID CONTROLLED-TRIAL; CO2 INSUFFLATION; SEDATED PATIENTS AB Colonoscopy remains the gold standard for colorectal cancer screening. Many barriers to the procedure exist including the possibility of abdominal discomfort that may occur with insufflation. Carbon dioxide (CO 2), which is rapidly absorbed in the blood stream, is an alternate method used to distend the lumen during colonoscopy. The goal of this study was to compare patient discomfort, abdominal girth, and recovery time in 2 groups of patients randomized to CO2 versus room air insufflation during colonoscopy. Using a Wong-Baker score, we found statistical difference in postprocedural discomfort levels (CO2 Group: 1.15 +/- 2.0 vs. room air: 0.41 +/- 0.31, p = .015) and a significantly greater increase in abdominal girth over CO2 immediately postprocedure (room air: 1.06 +/- 1.29 inches vs. CO2: 0.56 +/- 0.73 inches, p = .054) girth immediately postprocedure; however, recovery time was similar between the 2 study arms (CO2 : 9.1 +/- 16.2 minutes vs. room air: 10.2 +/- 18.6 minutes, p = .713). Further studies are needed to determine whether CO2 is cost-effective and improves patient satisfaction with colonoscopy. C1 [Chen, Yen-Ju; Lee, Jennifer; Wong, Roy K. H.; Lake, Jason M.; Maydonovitch, Corrine L.; Belle, Lavern] Walter Reed Natl Mil Med Ctr, Gastroenterol Serv, Dept Med, Bethesda, MD 20889 USA. [Puryear, Magaly] Ft Belvoir Community Hosp, Gastroenterol Serv, Dept Med, Ft Belvoir, VA USA. [Wong, Roy K. H.; Moawad, Fouad J.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Moawad, Fouad J.] US Army, Med Corps, Bethesda, MD USA. [Moawad, Fouad J.] Walter Reed Natl Mil Med Ctr, Motil & Reflux Testing Lab, Bethesda, MD 20889 USA. RP Chen, YJ (reprint author), Walter Reed Natl Mil Med Ctr, Manometry & Reflux Testing Lab, Gastroenterol Clin, 8901 Wisconsin Ave,Bldg 9, Bethesda, MD 20889 USA. EM yen-ju.chen@health.mil NR 12 TC 1 Z9 1 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1042-895X EI 1538-9766 J9 GASTROENTEROL NURS JI Gastroenterol. Nurs. PD JUL-AUG PY 2014 VL 37 IS 4 BP 273 EP 278 DI 10.1097/SGA.0000000000000054 PG 6 WC Gastroenterology & Hepatology; Nursing SC Gastroenterology & Hepatology; Nursing GA AP5BR UT WOS:000342095200003 PM 25078041 ER PT J AU Sanchez, AM Rountree, W Berrong, M Garcia, A Schuetz, A Cox, J Frahm, N Manak, M Sarzotti-Kelsoe, M D'Souza, MP Denny, T Ferrari, G AF Sanchez, Ana M. Rountree, Wes Berrong, Mark Garcia, Ambrosia Schuetz, Alexandra Cox, Josephine Frahm, Nicole Manak, Mark Sarzotti-Kelsoe, Marcella D'Souza, M. Patricia Denny, Thomas Ferrari, Guido TI The External Quality Assurance Oversight Laboratory (EQAPOL) proficiency program for IFN-gamma enzyme-linked immunospot (IFN-gamma ELISpot) assay SO JOURNAL OF IMMUNOLOGICAL METHODS LA English DT Review DE ELISpot; Standardization; Proficiency testing ID T-CELL RESPONSES; PEPTIDE VACCINE; PHASE-II; TRIALS; CANCER; HIV; INFECTIONS; GUIDELINES; CARCINOMA; PROTEIN AB The interferon-gamma enzyme-linked immunospot (IFN-gamma ELISpot) assay has been developed and used as an end-point assay in clinical trials for infectious diseases and cancer to detect the magnitude of antigen-specific immune responses. The ability to compare data generated by different laboratories across organizations is pivotal to understand the relative potency of different therapeutic and vaccine strategies. We developed an external proficiency program for the IFN-gamma ELISpot assay that evaluates laboratory performance based on five parameters: timeliness for data reporting; ability to handle cellular samples; detection of background (non-specific) responses; accuracy to consensus of the results; and precision of the measurements. Points are awarded for each criterion, and the sum of the points is used to determine a numeric and adjectival performance rating. Importantly, the evaluation of the accuracy to the consensus mean for the detection of antigen-specific responses using laboratory-specific procedures informs each laboratory and its sponsor on the degree of concordance of its results with those obtained by other laboratories. This study will ultimately provide the scientific community with information on how to organize and implement an external proficiency program to evaluate longitudinally the performance of the participating laboratories and, therefore, fulfill the requirements of the GCLP guidelines for laboratories performing end-point IFN-gamma ELISpot assay for clinical trials. (C) 2014 Elsevier B.V. All rights reserved. C1 [Sanchez, Ana M.; Rountree, Wes; Garcia, Ambrosia; Sarzotti-Kelsoe, Marcella; Denny, Thomas; Ferrari, Guido] Duke Univ, Med Ctr, Duke Human Vaccine Inst, Durham, NC 27710 USA. [Berrong, Mark; Sarzotti-Kelsoe, Marcella; Ferrari, Guido] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA. [Schuetz, Alexandra] USAMC AFRIMS, Dept Retrovirol, Bangkok, Thailand. [Cox, Josephine] Int AIDS Vaccine Initiat, New York, NY USA. [Frahm, Nicole] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Manak, Mark] Walter Reed Army Inst Res, Dept Diagnost & Monitoring, US Mil HIV Res Program MHRP, HJF, Silver Spring, MD USA. [Sarzotti-Kelsoe, Marcella] Duke Univ, Med Ctr, Dept Immunol, Durham, NC 27710 USA. [Sarzotti-Kelsoe, Marcella; Ferrari, Guido] Duke Univ, Med Ctr, Duke Ctr AIDS Res, Durham, NC 27710 USA. [D'Souza, M. Patricia] NIAID, Vaccine Clin Res Branch, Div Aids, Bethesda, MD 20892 USA. [Denny, Thomas] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA. [Denny, Thomas; Ferrari, Guido] Duke Univ, Med Ctr, Duke Global Hlth Inst, Durham, NC 27710 USA. RP Ferrari, G (reprint author), Duke Univ, Med Ctr, Dept Surg, POB 2926, Durham, NC 27710 USA. EM gflmp@duke.edu RI Ferrari, Guido/A-6088-2015 FU Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services [HHSN272201000045C] FX This project was funded in whole, or in part, by the Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under contract no. HHSN272201000045C entitled "External Quality Assurance Program Oversight Laboratory (EQAPOL)". NR 30 TC 6 Z9 7 U1 0 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1759 EI 1872-7905 J9 J IMMUNOL METHODS JI J. Immunol. Methods PD JUL PY 2014 VL 409 SI SI BP 31 EP 43 DI 10.1016/j.jim.2014.03.017 PG 13 WC Biochemical Research Methods; Immunology SC Biochemistry & Molecular Biology; Immunology GA AO7QW UT WOS:000341548700005 PM 24685833 ER PT J AU Sambor, A Garcia, A Berrong, M Pickeral, J Brown, S Rountree, W Sanchez, A Pollara, J Frahm, N Keinonen, S Kijak, GH Roederer, M Levine, G D'Souza, MP Jaimes, M Koup, R Denny, T Cox, J Ferrari, G AF Sambor, Anna Garcia, Ambrosia Berrong, Mark Pickeral, Joy Brown, Sara Rountree, Wes Sanchez, Ana Pollara, Justin Frahm, Nicole Keinonen, Sarah Kijak, Gustavo H. Roederer, Mario Levine, Gail D'Souza, M. Patricia Jaimes, Maria Koup, Richard Denny, Thomas Cox, Josephine Ferrari, Guido TI Establishment and maintenance of a PBMC repository for functional cellular studies in support of clinical vaccine trials SO JOURNAL OF IMMUNOLOGICAL METHODS LA English DT Review DE Peripheral blood mononuclear cells; Cryopreservation; Repository ID BLOOD MONONUCLEAR-CELLS; POLYCHROMATIC FLOW-CYTOMETRY; ANTIBODY-RESPONSES; ELISPOT ASSAYS; OPTIMIZATION; HIV-1; INFECTION; IMMUNITY; DESIGN; PANEL AB A large repository of cryopreserved peripheral blood mononuclear cells (PBMCs) samples was created to provide laboratories testing the specimens from human immunodeficiency virus-1 (HIV-1) vaccine clinical trials the material for assay development, optimization, and validation. One hundred thirty-one PBMC samples were collected using leukapheresis procedure between 2007 and 2013 by the Comprehensive T cell Vaccine Immune Monitoring Consortium core repository. The donors included 83 human immunodeficiency virus-1 (HIV-1) seronegative and 32 HIV-1 seropositive subjects. The samples were extensively characterized for the ability of T cell subsets to respond to recall viral antigens including cytomegalovirus, Epstein-Barr virus, influenza virus, and HIV-1 using Interferon-gamma (IFN-gamma) enzyme linked immunospot (ELISpot) and IFN-gamma/interleukin 2 (IL-2) intracellular cytokine staining (ICS) assays. A subset of samples was evaluated over time to determine the integrity of the cryopreserved samples in relation to recovery, viability, and functionality. The principal results of our study demonstrate that viable and functional cells were consistently recovered from the cryopreserved samples. Therefore, we determined that this repository of large size cryopreserved cellular samples constitutes a unique resource for laboratories that are involved in optimization and validation of assays to evaluate T, B, and NI( cellular functions in the context of clinical trials. (C) 2014 Elsevier B.V. All rights reserved. C1 [Sambor, Anna; Levine, Gail] Fdn Natl Inst Hlth, Bethesda, MD USA. [Garcia, Ambrosia; Brown, Sara; Rountree, Wes; Sanchez, Ana; Keinonen, Sarah; Denny, Thomas; Ferrari, Guido] Duke Univ, Duke Human Vaccine Inst, Durham, NC 27710 USA. [Garcia, Ambrosia; Berrong, Mark; Pickeral, Joy; Rountree, Wes; Sanchez, Ana; Pollara, Justin; Keinonen, Sarah; Denny, Thomas; Ferrari, Guido] Duke Univ, Med Ctr, Durham, NC 27710 USA. [Frahm, Nicole] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Kijak, Gustavo H.] Walter Reed Army Inst Res, Viral Genet Sect, US Mil HIV Res Program, Henry M Jackson Fdn Adv Mil Med, Silver Spring, MD USA. [Roederer, Mario; Koup, Richard] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. [D'Souza, M. Patricia] NIAD, Div Aids, NIH, Rockville, MD USA. [Jaimes, Maria] Becton Dickinson, San Jose, CA USA. [Cox, Josephine] Int AIDS Vaccine Initiat, New York, NY USA. RP Ferrari, G (reprint author), Duke Univ, Med Ctr, Dept Surg, POB 2926, Durham, NC 27710 USA. EM gflmp@duke.edu RI Ferrari, Guido/A-6088-2015 FU Bill & Melinda Gates Foundation [OPP1032325] FX This work was supported by a Collaboration for AIDS Vaccine Discovery (CAVD)/Comprehensive T Cell Vaccine Immune Monitoring Consortium (CTVIMC) grant from the Bill & Melinda Gates Foundation (Grant ID# OPP1032325). NR 31 TC 9 Z9 9 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1759 EI 1872-7905 J9 J IMMUNOL METHODS JI J. Immunol. Methods PD JUL PY 2014 VL 409 SI SI BP 107 EP 116 DI 10.1016/j.jim.2014.04.005 PG 10 WC Biochemical Research Methods; Immunology SC Biochemistry & Molecular Biology; Immunology GA AO7QW UT WOS:000341548700013 PM 24787274 ER PT J AU Maurer, EP Brekke, L Pruitt, T Thrasher, B Long, J Duffy, P Dettinger, M Cayan, D Arnold, J AF Maurer, E. P. Brekke, L. Pruitt, T. Thrasher, B. Long, J. Duffy, P. Dettinger, M. Cayan, D. Arnold, J. TI AN ENHANCED ARCHIVE FACILITATING CLIMATE IMPACTS AND ADAPTATION ANALYSIS SO BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY LA English DT Article ID CHANGE SCENARIOS; CALIFORNIA; FUTURE; PRECIPITATION; INFORMATION; SENSITIVITY; MODELS; TEMPERATURE; VARIABILITY; PROJECTIONS AB We describe the expansion of a publicly available archive of downscaled climate and hydrology projections for the United States. Those studying or planning to adapt to future climate impacts demand downscaled climate model output for local or regional use. The archive we describe attempts to fulfill this need by providing data in several formats, selectable to meet user needs. Our archive has served as a resource for climate impacts modelers, water managers, educators, and others. Over 1,400 individuals have transferred more than 50 TB of data from the archive. In response to user demands, the archive has expanded from monthly downscaled data to include daily data to facilitate investigations of phenomena sensitive to daily to monthly temperature and precipitation, including extremes in these quantities. New developments include downscaled output from the new Coupled Model Intercomparison Project phase 5 (CMIP5) climate model simulations at both the monthly and daily time scales, as well as simulations of surface hydrological variables. The web interface allows the extraction of individual projections or ensemble statistics for user-defined regions, promoting the rapid assessment of model consensus and uncertainty for future projections of precipitation, temperature, and hydrology. The archive is accessible online (http://gdo-dcp.ucllnl.org/downscaled_cmip_projections). C1 [Maurer, E. P.] Santa Clara Univ, Dept Civil Engn, Santa Clara, CA 95053 USA. [Brekke, L.; Pruitt, T.] US Bur Reclamat, Tech Serv Ctr 86 68520, Denver, CO 80225 USA. [Thrasher, B.] Climate Analyt Grp, Palo Alto, CA USA. [Thrasher, B.] Climate Cent, Princeton, NJ USA. [Long, J.; Duffy, P.] Lawrence Livermore Natl Lab, Livermore, CA USA. [Dettinger, M.; Cayan, D.] US Geol Survey, La Jolla, CA USA. [Dettinger, M.; Cayan, D.] Univ Calif San Diego, Scripps Inst Oceanog, Div Climate Atmospher Sci & Phys Oceanog, La Jolla, CA 92093 USA. [Arnold, J.] US Army Corps Engineers, Inst Water Resources, Alexandria, VA USA. RP Maurer, EP (reprint author), Santa Clara Univ, Dept Civil Engn, 500 El Camino Real, Santa Clara, CA 95053 USA. EM emaurer@engr.scu.edu RI Maurer, Edwin/C-7190-2009; OI Maurer, Edwin/0000-0001-7134-487X; Thrasher, Bridget/0000-0002-3961-1971 FU Bureau of Reclamation's Science and Technology Program; WaterSMART grants; California Energy Commission (CEC); U.S. Department of the Interior Southwest Climate Science Center FX We acknowledge the World Climate Research Programme's Working Group on Coupled Modelling, which is responsible for CMIP, and we thank the climate modeling groups for producing and making available their model output. For CMIP the U.S. Department of Energy's Program for Climate Model Diagnosis and Intercomparison provides coordinating support and led development of software infrastructure in partnership with the Global Organization for Earth System Science Portals. Portions of the archive dataset were produced using computational facilities of the NASA Earth Exchange (www.nex.nasa.gov). This work was supported by the Bureau of Reclamation's Science and Technology Program (data service development) and by WaterSMART grants to develop Climate Data Analysis Tools. Support was also provided by the California Energy Commission (CEC)-funded California Climate Change Center under the CEC PIER Program and by the U.S. Department of the Interior Southwest Climate Science Center. NR 57 TC 14 Z9 14 U1 2 U2 19 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0003-0007 EI 1520-0477 J9 B AM METEOROL SOC JI Bull. Amer. Meteorol. Soc. PD JUL PY 2014 VL 95 IS 7 BP 1011 EP + DI 10.1175/BAMS-D-13-00126.1 PG 10 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA AO0ED UT WOS:000340981000010 ER PT J AU Garcia-Reyero, N Ekman, DR Habib, BT Villeneuve, DL Collette, TW Bencic, DC Ankley, GT Perkins, EJ AF Garcia-Reyero, Natalia Ekman, Drew R. Habib, B. Tanwir Villeneuve, Daniel L. Collette, Timothy W. Bencic, David C. Ankley, Gerald T. Perkins, Edward J. TI Integrated approach to explore the mechanisms of aromatase inhibition and recovery in fathead minnows (Pimephales promelas) SO GENERAL AND COMPARATIVE ENDOCRINOLOGY LA English DT Article DE Fathead minnow; Aromatase; Fadrozole; Transcriptomics; Metabolomics; Integrative analysis ID GROWTH-FACTOR-I; GENE-EXPRESSION; SEX-DIFFERENTIATION; ENERGY-METABOLISM; MOLECULAR-BIOLOGY; ORYZIAS-LATIPES; MESSENGER-RNA; SPARUS-AURATA; KGN CELLS; FISH AB Aromatase, a member of the cytochrome P450 superfamily, is a key enzyme in estradiol synthesis that catalyzes the aromatization of androgens into estrogens in ovaries. Here, we used an integrated approach to assess the mechanistic basis of the direct effects of aromatase inhibition, as well as adaptation and recovery processes in fish. We exposed female fathead minnows (Pimephales promelas) via the water to 30 mu g/L of a model aromatase inhibitor, fadrozole, during 8 days (exposure phase). Fish were then held in clean water for 8 more days (recovery phase). Samples were collected at 1, 2, 4, and 8 days of both the exposure and the recovery phases. Transcriptomics, metabolomics, and network inference were used to understand changes and infer connections at the transcript and metabolite level in the ovary. Apical end-points directly indicative of endocrine function, such as plasma estradiol, testosterone, and vitellogenin levels were also measured. An integrated analysis of the data revealed changes in gene expression consistent with increased testosterone in fadrozole-exposed ovaries. Metabolites such as glycogen and taurine were strongly correlated with increased testosterone levels. Comparison of in vivo and ex vivo steroidogenesis data suggested the accumulation of steroidogenic enzymes, including aromatase, as a mechanism to compensate for aromatase inhibition. (C) 2014 Elsevier Inc. All rights reserved. C1 [Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS 39759 USA. [Ekman, Drew R.; Collette, Timothy W.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Athens, GA 30605 USA. [Habib, B. Tanwir] Badger Tech Serv, San Antonio, TX 78216 USA. [Villeneuve, Daniel L.; Ankley, Gerald T.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN USA. [Bencic, David C.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Ecol Exposures Res Div, Cincinnati, OH 45268 USA. [Perkins, Edward J.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Garcia-Reyero, N (reprint author), 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM nvinas@igbb.msstate.edu FU US Army Environmental Quality Research Program [BAA 11-4838] FX We thank many scientists who contributed to generation of aspects of the data described herein, including N. Mueller, D. Martinovic, E. Mayknen, M. Kahl, K. Jensen, E. Durhan, and J. Cavallin. This work was funded by the US Army Environmental Quality Research Program (including BAA 11-4838). Permission for publishing this information has been granted by the Chief of Engineers. Although this paper has been approved for publication by the US EPA, the views expressed herein do not necessarily reflect EPA positions or policy. NR 77 TC 7 Z9 7 U1 1 U2 21 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0016-6480 EI 1095-6840 J9 GEN COMP ENDOCR JI Gen. Comp. Endocrinol. PD JUL 1 PY 2014 VL 203 SI SI BP 193 EP 202 DI 10.1016/j.ygcen.2014.03.022 PG 10 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA AO1LJ UT WOS:000341073300022 PM 24704562 ER PT J AU Garcia-Reyero, N Tingaud-Sequeira, A Cao, MX Zhu, ZY Perkins, EJ Hu, W AF Garcia-Reyero, Natalia Tingaud-Sequeira, Angele Cao, Mengxi Zhu, Zuoyan Perkins, Edward J. Hu, Wei TI Endocrinology: Advances through omics and related technologies SO GENERAL AND COMPARATIVE ENDOCRINOLOGY LA English DT Article DE Omics; Reproduction; Transgenic organisms; Integrative systems biology ID ZEBRAFISH DANIO-RERIO; SALMON ONCORHYNCHUS-KISUTCH; MINNOWS PIMEPHALES-PROMELAS; GROWTH-HORMONE SYNTHESIS; PITUITARY-GONADAL AXIS; GENE-EXPRESSION; DAPHNIA-MAGNA; MESSENGER-RNA; SYSTEMS BIOLOGY; RAINBOW-TROUT AB The rapid development of new omics technologies to measure changes at genetic, transcriptomic, proteomic, and metabolomics levels together with the evolution of methods to analyze and integrate the data at a systems level are revolutionizing the study of biological processes. Here we discuss how new approaches using omics technologies have expanded our knowledge especially in nontraditional models. Our increasing knowledge of these interactions and evolutionary pathway conservation facilitates the use of nontraditional species, both invertebrate and vertebrate, as new model species for biological and endocrinology research. The increasing availability of technology to create organisms overexpressing key genes in endocrine function allows manipulation of complex regulatory networks such as growth hormone (GH) in transgenic fish where disregulation of GH production to produce larger fish has also permitted exploration of the role that GH plays in testis development, suggesting that it does so through interactions with insulin-like growth factors. The availability of omics tools to monitor changes at nearly any level in any organism, manipulate gene expression and behavior, and integrate data across biological levels, provides novel opportunities to explore endocrine function across many species and understand the complex roles that key genes play in different aspects of the endocrine function. (C) 2014 Elsevier Inc. All rights reserved. C1 [Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS 39759 USA. [Tingaud-Sequeira, Angele] Univ Bordeaux, Lab MRMG, F-33405 Talence, France. [Cao, Mengxi; Zhu, Zuoyan; Hu, Wei] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China. [Cao, Mengxi] Univ Chinese Acad Sci, Beijing 100049, Peoples R China. [Perkins, Edward J.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Garcia-Reyero, N (reprint author), 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM nvinas@igbb.msstate.edu RI TINGAUD-SEQUEIRA, Angela/M-6023-2014 FU US Army Environmental Quality Research Program [BAA 11-4838]; "863" High Technology Project [2011AA100404]; National Natural Science Foundation [30930069]; Development Plan of the State Key Fundamental Research of China [2010CB126302]; Key Research Program of the Chinese Academy of Sciences [KSCX2-EW-N-004]; Conseil Regional d'Aquitaine, France [200881301031/TOD project]; Agence Nationale de la Recherche (ANR) [2010BLAN 1126 01/LIGENAX project] FX This work was funded by the US Army Environmental Quality Research Program (including BAA 11-4838). Permission for publishing this information has been granted by the Chief of Engineers. This work was also supported financially by the "863" High Technology Project (Grant No. 2011AA100404), National Natural Science Foundation (Grant No. 30930069), the Development Plan of the State Key Fundamental Research of China (Grant No. 2010CB126302), and the Key Research Program of the Chinese Academy of Sciences (Grant No. KSCX2-EW-N-004). In addition, this work was supported by the Conseil Regional d'Aquitaine, France (Grant No. 200881301031/TOD project) and the Agence Nationale de la Recherche (ANR Grant No. 2010BLAN 1126 01/LIGENAX project). NR 172 TC 4 Z9 4 U1 4 U2 25 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0016-6480 EI 1095-6840 J9 GEN COMP ENDOCR JI Gen. Comp. Endocrinol. PD JUL 1 PY 2014 VL 203 SI SI BP 262 EP 273 DI 10.1016/j.ygcen.2014.03.042 PG 12 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA AO1LJ UT WOS:000341073300029 PM 24726988 ER PT J AU Pasiakos, SM Carbone, JW AF Pasiakos, Stefan M. Carbone, John W. TI Assessment of Skeletal Muscle Proteolysis and the Regulatory Response to Nutrition and Exercise SO IUBMB LIFE LA English DT Review DE ubiquitin proteasome; lysosomes; protein breakdown; exercise; amino acids ID UBIQUITIN-PROTEASOME PATHWAY; FRACTIONAL BREAKDOWN RATE; AMINO-ACID-TRANSPORT; RATE IN-VIVO; RESISTANCE EXERCISE; PROTEIN-SYNTHESIS; ENDURANCE EXERCISE; ANABOLIC RESPONSE; LYSOSOMAL PROTEOLYSIS; DIETARY-PROTEIN AB Skeletal muscle proteolysis is highly regulated, involving complex intramuscular proteolytic systems that recognize and degrade muscle proteins, and recycle free amino acid precursors for protein synthesis and energy production. Autophagylysosomal, calpain, and caspase systems are contributors to muscle proteolysis, although the ubiquitin proteasome system (UPS) is the primary mechanism by which actomyosin fragments are degraded in healthy muscle. The UPS is sensitive to mechanical force and nutritional deprivation, as recent reports have demonstrated increased proteolytic gene expression and activity of the UPS in response to resistance and endurance exercise, and short-term negative energy balance. However, consuming dietary protein alone (or free amino acids), or as a primary component of a mixed meal, may attenuate intramuscular protein loss by down-regulating proteolytic gene expression and the catabolic activity of the UPS. Although these studies provide novel insight regarding the intramuscular regulation of skeletal muscle mass, the role of proteolysis in the regulation of skeletal muscle protein turnover in healthy human muscle is not well described. This article provides a contemporary review of the intramuscular regulation of skeletal muscle proteolysis in healthy muscle, methodological approaches to assess proteolysis, and highlights the effects of nutrition and exercise on skeletal muscle proteolysis. (C) 2014 IUBMB Life, 66(7): 478-484, 2014 C1 [Pasiakos, Stefan M.] US Army, Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. [Carbone, John W.] Eastern Michigan Univ, Sch Hlth Sci, Ypsilanti, MI 48197 USA. RP Pasiakos, SM (reprint author), 15 Kansas St Bldg 42, Natick, MA 01760 USA. EM stefan.pasiakos@us.army.mil RI Pasiakos, Stefan/E-6295-2014 OI Pasiakos, Stefan/0000-0002-5378-5820 FU US Army Military Research and Material Command; Eastern Michigan University College of Health and Human Services FX The authors thank Dr. Andrew Young and Dr. Scott Montain for their critical review in support of the development of this manuscript. All authors have read and approved the final manuscript. This work has been supported by the US Army Military Research and Material Command and the Eastern Michigan University College of Health and Human Services. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Army or the Department of Defense. Any citations of commercial organizations and trade names in this report do not constitute an official Department of the Army endorsement of approval of the products or services of these organizations. NR 77 TC 6 Z9 7 U1 2 U2 12 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1521-6543 EI 1521-6551 J9 IUBMB LIFE JI IUBMB Life PD JUL PY 2014 VL 66 IS 7 BP 478 EP 484 DI 10.1002/iub.1291 PG 7 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA AN4RK UT WOS:000340575200005 PM 25052691 ER PT J AU Cooper, D Troth, T Chin, EJ Hughes, J AF Cooper, David Troth, Thomas Chin, Eric J. Hughes, John TI Graduate Medical Education in Combat Support Hospitals: An Enlightening Experience in a British-Led Combat Support Hospital SO MILITARY MEDICINE LA English DT Editorial Material ID MILITARY OPERATIONS; US MILITARY; SURGEON; RESUSCITATION; AFGHANISTAN; TRAUMA; WAR; UK C1 [Cooper, David; Troth, Thomas] Bast Hosp, Fleet Post Off, APO, AE 09372 USA. [Chin, Eric J.; Hughes, John] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Cooper, D (reprint author), Bast Hosp, Fleet Post Off, APO, AE 09372 USA. NR 9 TC 1 Z9 1 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUL PY 2014 VL 179 IS 7 BP 697 EP 701 DI 10.7205/MILMED-D-13-00411 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UN UT WOS:000340806600001 PM 25003850 ER PT J AU Moe, CD Keiser, PB AF Moe, Christopher D. Keiser, Paul B. TI Should US Troops Routinely Get Rabies Pre-Exposure Prophylaxis? SO MILITARY MEDICINE LA English DT Editorial Material ID VACCINE; IMMUNIZATION; ADJUVANT; FUTURE C1 [Moe, Christopher D.] Brigade Med Operat, St Airborne Div 101st, Brigade Combat Team 1st, Fort Campbell, KY 42223 USA. [Keiser, Paul B.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD 20910 USA. RP Moe, CD (reprint author), Brigade Med Operat, St Airborne Div 101st, Brigade Combat Team 1st, Bldg A3781,53rd St, Fort Campbell, KY 42223 USA. NR 17 TC 0 Z9 0 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUL PY 2014 VL 179 IS 7 BP 702 EP 703 DI 10.7205/MILMED-D-14-00053 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UN UT WOS:000340806600002 PM 25003851 ER PT J AU Dailey, JI Stanfa-Brew, MR AF Dailey, Jason I. Stanfa-Brew, Meffissa R. TI Telebehavioral Health in Afghanistan SO MILITARY MEDICINE LA English DT Article ID CARE; MILITARY AB Providing behavioral health care to numerous beneficiaries spread over a large and dangerous area is a unique and challenging responsibility faced by the U.S. Army in the deployed environment. We describe the use of telebehavioral health as one tool available to behavioral health officers in Afghanistan to reach remote service members when face-to-face encounters are not possible or practical. Finally, challenges to the current telebehavioral system established during Operation Enduring Freedom are discussed, with recommendations made for implementation in future deployed settings. C1 [Dailey, Jason I.] Air Assault, Airborne Div 101st, Div Surg Sect, Fort Campbell, KY 42223 USA. [Stanfa-Brew, Meffissa R.] US Army, Clin & Tech Expertise Div, Hlth Facil Planning Agcy, Falls Church, VA 22042 USA. RP Dailey, JI (reprint author), Air Assault, Airborne Div 101st, Div Surg Sect, 6906 A Shan Valley Rd, Fort Campbell, KY 42223 USA. NR 6 TC 0 Z9 0 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUL PY 2014 VL 179 IS 7 BP 708 EP 710 DI 10.7205/MILMED-D-13-00538 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UN UT WOS:000340806600004 PM 25003853 ER PT J AU Donelan, K Romano, C DesRoches, C Applebaum, S Ward, JRM Schoneboom, BA Hinshaw, AS AF Donelan, Karen Romano, Carol DesRoches, Catherine Applebaum, Sandra Ward, Johanna R. M. Schoneboom, Bruce A. Hinshaw, Ada Sue TI National Surveys of Military Personnel, Nursing Students, and the Public: Drivers of Military Nursing Careers (vol 179, pg 565, 2014) SO MILITARY MEDICINE LA English DT Correction C1 [Donelan, Karen] Massachusetts Gen Hosp, Mongan Inst Hlth Policy, Boston, MA 02114 USA. [Romano, Carol; Hinshaw, Ada Sue] Uniformed Serv Univ Hlth Sci, Grad Sch Nursing, Bethesda, MD 20814 USA. [DesRoches, Catherine] Vanderbilt Univ, Ctr Med, Ctr Interdisciplinary Hlth Workforce Studies, Inst Med & Publ Hlth, Nashville, TN 37203 USA. [Applebaum, Sandra] Math Policy Res, Cambridge, MA 02139 USA. [Ward, Johanna R. M.] Harris Interact Inc, New York, NY 10010 USA. [Schoneboom, Bruce A.] US Army, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Donelan, K (reprint author), Massachusetts Gen Hosp, Mongan Inst Hlth Policy, 50 Staniford St,9th floor, Boston, MA 02114 USA. NR 1 TC 0 Z9 0 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUL PY 2014 VL 179 IS 7 BP 792 EP 792 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UN UT WOS:000340806600024 ER PT J AU Hout, JJ White, DW Artino, AR Knapik, JJ AF Hout, Joseph J. White, Duvel W. Artino, Anthony R. Knapik, Joseph J. TI o-Chlorobenzylidene Malononitrile (CS Riot Control Agent) Associated Acute Respiratory Illnesses in a US Army Basic Combat Training Cohort SO MILITARY MEDICINE LA English DT Article ID TEAR GAS; INFECTION; TRAINEES; DISEASES AB Acute respiratory illnesses (ARIs) are among the leading causes for hospital visits in U.S. military training populations and historically peak during U.S. Army Basic Combat Training (B CT) following mandatory exposure to the riot control agent o-chlorobenzylidene malononitrile (CS). This observational prospective cohort studied the association between CS exposures and ART-related health outcomes in 6,723 U.S. Army recruits attending BCT at Fort Jackson, South Carolina from August 1 to September 25, 2012 by capturing and linking the incidence of ART before and after the mask confidence chamber to CS exposure data. Recruits had a significantly higher risk (risk ratio = 2.44; 95% confidence interval =1.74, 3.43) of being diagnosed with ART following exposure to CS compared to the period of training preceding exposure, and incidence of ART after CS exposure was dependent on the CS exposure concentration (p = 0.03). There was a significant pre-/postexposure ART difference across all CS concentration levels (p < 0.01), however, no significant differences were detected among these rate ratios (p = 0.72). As CS exposure is positively associated with ART health outcomes in this population, interventions designed to reduce respiratory exposures could result in decreased hospital burden and lost training time in the U.S. Army BCT population. C1 [Hout, Joseph J.; White, Duvel W.; Artino, Anthony R.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Knapik, Joseph J.] US Army, Inst Publ Hlth, Aberdeen Proving Ground, MD 21010 USA. RP Hout, JJ (reprint author), Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. OI Artino, Anthony/0000-0003-2661-7853 FU U.S. Army Medical Command, Office of the Surgeon General, Falls Church, Virginia FX This work was sponsored by the U.S. Army Medical Command, Office of the Surgeon General, Falls Church, Virginia. NR 23 TC 3 Z9 3 U1 0 U2 5 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUL PY 2014 VL 179 IS 7 BP 793 EP 798 DI 10.7205/MILMED-D-13-00514 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UN UT WOS:000340806600026 PM 25003867 ER PT J AU Evanson, JR Guyton, MK Oliver, DL Hire, JM Topolski, RL Zumbrun, SD McPherson, JC Bojescul, JA AF Evanson, J. Richard Guyton, M. Kelly Oliver, David L. Hire, Justin M. Topolski, Richard L. Zumbrun, Steven D. McPherson, James C. Bojescul, John A. TI Gender and Age Differences in Growth Factor Concentrations From Platelet-Rich Plasma in Adults SO MILITARY MEDICINE LA English DT Article ID SPORTS-MEDICINE; TENDON; GENE; SEX; PROTEINS; TEARS AB The use of platelet-rich plasma (PRP) to facilitate healing of orthopedic-related injuries has gained popularity; however, the clinical benefits are not consistent. Differences may result from variations in growth factor (GF) levels in normal populations. The purpose of this study was to determine if GF levels present in activated PRP preparations differed by gender and age (<= 25 versus >25 years) in a healthy population (N = 102). All GFs analyzed (epidermal growth factor [EGF], hepatocyte growth factor [HGF], insulin growth factor-1 [IGF-1], platelet-derived growth factor-AB [PDGF-AB], platelet-derived growth factor-BB [PDGF-BB], transforming growth factor beta-1 [TGF beta-1], and vascular endothelial growth factor) had higher levels for females and for those <= 25 years old. Of the GFs tested, four of seven were significantly higher (p < 0.05) for females (EGF, HGF, IGF-1, PDGF-BB), the most significant being IGF-1 (female, 85.0; male, 69.3 ng/mL; p < 0.01). Five of seven GFs achieved significance (p < 0.05) for people <= 25 years old (EGF, IGF-1, PDGP-AB, PDGF-BB, and TGF beta-1), with IGF and PDGF-AB achieving p < 0.001 (<= 25 years, 85.1; >25 years, 56.8, and <= 25 years, 7.66; >25 years, 5.77 ng/mL, respectively). Finally, for both genders, most of the GFs were positively correlated with all GFs. This study demonstrated that both age and gender account for variations in specific GFs present in PEP, and this may partially explain some of the inconsistent results of PEP clinical trials. C1 [Evanson, J. Richard; Oliver, David L.; Hire, Justin M.; Bojescul, John A.] Dwight D Eisenhower Army Med Ctr, Dept Orthopaed, Ft Gordon, GA 30905 USA. [Guyton, M. Kelly; Topolski, Richard L.; Zumbrun, Steven D.; McPherson, James C.] Dept Clin Invest, Ft Gordon, GA 30905 USA. RP Evanson, JR (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Orthopaed, 300 Hosp Rd, Ft Gordon, GA 30905 USA. FU Department of Clinical Investigation at Fort Gordon FX We would like to thank the military and civilian staff of Kendrick Memorial Donor Center for their enormous assistance with this project. The funding for this project was acquired through the Department of Clinical Investigation at Fort Gordon. NR 32 TC 3 Z9 3 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUL PY 2014 VL 179 IS 7 BP 799 EP 805 DI 10.7205/MILMED-D-13-00336 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UN UT WOS:000340806600027 PM 25003868 ER PT J AU Garamszegi, S Yen, JY Honko, AN Geisbert, JB Rubins, KH Geisbert, TW Xia, Y Hensley, LE Connor, JH AF Garamszegi, Sara Yen, Judy Y. Honko, Anna N. Geisbert, Joan B. Rubins, Kathleen H. Geisbert, Thomas W. Xia, Yu Hensley, Lisa E. Connor, John H. TI Transcriptional Correlates of Disease Outcome in Anticoagulant-Treated Non-Human Primates Infected with Ebolavirus SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID BINDING-PROTEIN-BETA; HEMORRHAGIC-FEVER; VIRUS INFECTION; HEPATITIS-C; MARBURG VIRUSES; GENE-EXPRESSION; DENDRITIC CELLS; MICROARRAY DATA; POSTEXPOSURE TREATMENT; CYNOMOLGUS MACAQUES AB Ebola virus (EBOV) infection in humans and non-human primates (NHPs) is highly lethal, and there is limited understanding of the mechanisms associated with pathogenesis and survival. Here, we describe a transcriptomic analysis of NHPs that survived lethal EBOV infection, compared to NHPs that did not survive. It has been previously demonstrated that anticoagulant therapeutics increase the survival rate in EBOV-infected NHPs, and that the characteristic transcriptional profile of immune response changes in anticoagulant-treated NHPs. In order to identify transcriptional signatures that correlate with survival following EBOV infection, we compared the mRNA expression profile in peripheral blood mononuclear cells from EBOV-infected NHPs that received anticoagulant treatment, to those that did not receive treatment. We identified a small set of 20 genes that are highly confident predictors and can accurately distinguish between surviving and non-surviving animals. In addition, we identified a larger predictive signature of 238 genes that correlated with disease outcome and treatment; this latter signature was associated with a variety of host responses, such as the inflammatory response, T cell death, and inhibition of viral replication. Notably, among survival-associated genes were subsets of genes that are transcriptionally regulated by (1) CCAAT/enhancer-binding protein alpha, (2) tumor protein 53, and (3) megakaryoblastic leukemia 1 and myocardin-like protein 2. These pathways merit further investigation as potential transcriptional signatures of host immune response to EBOV infection. C1 [Garamszegi, Sara; Xia, Yu; Connor, John H.] Boston Univ, Bioinformat Program, Boston, MA 02215 USA. [Yen, Judy Y.; Connor, John H.] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02215 USA. [Yen, Judy Y.; Connor, John H.] Boston Univ, Natl Emerging Infect Dis Labs, Boston, MA 02215 USA. [Honko, Anna N.] US Army Med Res Inst Infect Dis, Frederick, MD USA. [Geisbert, Joan B.; Geisbert, Thomas W.] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA. [Rubins, Kathleen H.] Natl Aeronaut & Space Adm, Houston, TX USA. [Xia, Yu] McGill Univ, Dept Bioengn, Montreal, PQ, Canada. [Hensley, Lisa E.] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD USA. RP Garamszegi, S (reprint author), Boston Univ, Bioinformat Program, Boston, MA 02215 USA. EM jhconnor@bu.edu OI Connor, John/0000-0002-8867-7256; Xia, Yu/0000-0002-5596-5518; Honko, Anna/0000-0001-9165-148X FU National Science Foundation (NSF) Integrative Graduate Education and Research Traineeship [DGE-0654108]; NSF Graduate Research Fellowship [DGE-0741448]; Pharmaceutical Research and Manufacturers of America Foundation; Joint Science and Technology Office for Chemical and Biological Defense; Defense Threat Reduction Agency [JSTO-CBD 4.0021.08.RD.B]; USAMRIID [19595, 188261]; JSTO-CBD FX SG was supported by a fellowship from the National Science Foundation (NSF) Integrative Graduate Education and Research Traineeship (DGE-0654108) and an NSF Graduate Research Fellowship (DGE-0741448). YX was supported by a Research Starter Grant in Informatics from the Pharmaceutical Research and Manufacturers of America Foundation. Funding for experimental animal studies was provided by the Joint Science and Technology Office for Chemical and Biological Defense and the Defense Threat Reduction Agency (JSTO-CBD 4.0021.08.RD.B). This work was conducted at USAMRIID under project numbers 19595 and 188261 supported by JSTO-CBD. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 83 TC 7 Z9 7 U1 0 U2 24 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD JUL PY 2014 VL 8 IS 7 AR e3061 DI 10.1371/journal.pntd.0003061 PG 14 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AN4IQ UT WOS:000340551500076 PM 25079789 ER PT J AU Bayne, S Lacouture, S Lawson, K Giesselmann, M Scozzie, CJ O'Brien, H Ogunniyi, AA AF Bayne, Stephen Lacouture, Shelby Lawson, Kevin Giesselmann, Michael Scozzie, Charles J. O'Brien, Heather Ogunniyi, Aderinto A. TI An evaluation system for experimental silicon and silicon carbide super gate turn off thyristors SO REVIEW OF SCIENTIFIC INSTRUMENTS LA English DT Article AB This paper describes the design and implementation of a small-scale pulsed power system specifically intended to evaluate the suitability of experimental silicon and silicon carbide high power Super Gate Turn Off thyristors for high action (500 A(2) s and above) pulsed power applications where energy is extracted from a storage element in a rapid and controlled manner. To this end, six of each type of device was placed in a controlled three phase rectifier circuit which was in turn connected to an aircraft ground power motor-generator set and subjected to testing protocols with varying power levels, while parameters such as offset firing angle were varied. (C) 2014 AIP Publishing LLC. C1 [Bayne, Stephen; Lacouture, Shelby; Lawson, Kevin; Giesselmann, Michael] Texas Tech Univ, Dept Elect Engn, Lubbock, TX 79409 USA. [Scozzie, Charles J.; O'Brien, Heather; Ogunniyi, Aderinto A.] US Army Res Lab, Adelphi, MD 20783 USA. RP Bayne, S (reprint author), Texas Tech Univ, Dept Elect Engn, 1012 Boston Ave, Lubbock, TX 79409 USA. FU Army Research Laboratory [W911NF-10-2-0018] FX We would like to thank Army Research Laboratory (Contract No. W911NF-10-2-0018) for supporting this work and for lending their technical expertise. NR 9 TC 0 Z9 0 U1 1 U2 3 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0034-6748 EI 1089-7623 J9 REV SCI INSTRUM JI Rev. Sci. Instrum. PD JUL PY 2014 VL 85 IS 7 AR 075107 DI 10.1063/1.4885449 PG 5 WC Instruments & Instrumentation; Physics, Applied SC Instruments & Instrumentation; Physics GA AO2SQ UT WOS:000341176600054 PM 25085173 ER PT J AU Ingraham, JM Deng, ZD Li, X Fu, T McMichael, GA Trumbo, BA AF Ingraham, J. M. Deng, Z. D. Li, X. Fu, T. McMichael, G. A. Trumbo, B. A. TI A fast and accurate decoder for underwater acoustic telemetry SO REVIEW OF SCIENTIFIC INSTRUMENTS LA English DT Article ID SALMON; SYSTEM; TURBINES; PASSAGE; INSTRUMENTATION; SURVIVAL; TRACKING; DESIGN AB The Juvenile Salmon Acoustic Telemetry System, developed by the U. S. Army Corps of Engineers, Portland District, has been used to monitor the survival of juvenile salmonids passing through hydroelectric facilities in the Federal Columbia River Power System. Cabled hydrophone arrays deployed at dams receive coded transmissions sent from acoustic transmitters implanted in fish. The signals' time of arrival on different hydrophones is used to track fish in 3D. In this article, a new algorithm that decodes the received transmissions is described and the results are compared to results for the previous decoding algorithm. In a laboratory environment, the new decoder was able to decode signals with lower signal strength than the previous decoder, effectively increasing decoding efficiency and range. In field testing, the new algorithm decoded significantly more signals than the previous decoder and three-dimensional tracking experiments showed that the new decoder's time-of-arrival estimates were accurate. At multiple distances from hydrophones, the new algorithm tracked more points more accurately than the previous decoder. The new algorithm was also more than 10 times faster, which is critical for real-time applications on an embedded system. (C) 2014 AIP Publishing LLC. C1 [Ingraham, J. M.; Deng, Z. D.; Li, X.; Fu, T.; McMichael, G. A.] Pacific NW Natl Lab, Richland, WA 99332 USA. [Trumbo, B. A.] US Army Corps Engineers, Walla Walla, WA 99362 USA. RP Deng, ZD (reprint author), Pacific NW Natl Lab, POB 999, Richland, WA 99332 USA. EM zhiqun.deng@pnnl.gov RI Deng, Daniel/A-9536-2011 OI Deng, Daniel/0000-0002-8300-8766 FU U.S. Army Corps of Engineers (USACE) FX This research was funded by the U.S. Army Corps of Engineers (USACE). We greatly appreciate the assistance of USACE staff members including Martin Ahmann, Brad Eppard, Derek Fryer, Mike Langeslay, Steve Juhnke, Marvin Shutters, and Jon Renholds. Critical assistance also was provided by many staff members of the Pacific Northwest National Laboratory, including Ki Won Jung, Jun Lu, Jayson Martinez, Mitchell Myjak, Mark Weiland, and Maura Zimmerschied. NR 25 TC 1 Z9 1 U1 0 U2 12 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0034-6748 EI 1089-7623 J9 REV SCI INSTRUM JI Rev. Sci. Instrum. PD JUL PY 2014 VL 85 IS 7 AR 074903 DI 10.1063/1.4891041 PG 8 WC Instruments & Instrumentation; Physics, Applied SC Instruments & Instrumentation; Physics GA AO2SQ UT WOS:000341176600043 PM 25085162 ER PT J AU Baird, JK RictitE, TL Hoffman, SL Palmieri, JR Franice-Vellasante, E Ohrt, C Punjabi, N Maguire, JD Elyazar, I Dennis, DT Basri, H Sutanto, I Chand, K Andersen, E Sismadi, P Fryauff, DJ AF Baird, J. Kevin RictitE, Thomas L. Hoffman, Stephen L. Palmieri, James R. Franice-Vellasante, Eileen Ohrt, Colin Punjabi, Narian Maguire, Jason D. Elyazar, Iqbal Dennis, David T. Basri, Hasan Sutanto, Inge Chand, Krism Andersen, Ellen Sismadi, Prianto Fryauff, David J. TI Purnomo Projodipuro 11 April 1933-10 May 2013 Obituary SO COMPARATIVE PARASITOLOGY LA English DT Biographical-Item C1 [Baird, J. Kevin; Elyazar, Iqbal; Basri, Hasan; Chand, Krism] Eijkman Oxford Clin Res Unit, Jakarta, Indonesia. [Hoffman, Stephen L.] Sanaria Inc, Rockville, MD USA. [Palmieri, James R.] Virginia Tech Univ, Blacksburg, VA USA. [Franice-Vellasante, Eileen; Fryauff, David J.] Naval Med Res Ctr, Silver Spring, MD USA. [Ohrt, Colin] Walter Reed Army Inst Res, Silver Spring, MD USA. [Punjabi, Narian] Int SOS, Jakarta, Indonesia. [Maguire, Jason D.] Portsmouth Naval Hosp, Portsmouth, VA USA. [Dennis, David T.] US Ctr Dis Control, Ft Collins, CO USA. [Sutanto, Inge] Univ Indonesia, Fac Med, Jakarta, Indonesia. [Andersen, Ellen] USN Ret, MSC, LCDR, Washington, DC USA. [Sismadi, Prianto] Sismadi Hlth Sci & Res Inst, Jakarta, Indonesia. [Fryauff, David J.] Naval Med Res Ctr, Silver Spring, MD USA. RP Baird, JK (reprint author), Eijkman Oxford Clin Res Unit, Jakarta, Indonesia. NR 1 TC 0 Z9 0 U1 0 U2 0 PU HELMINTHOLOGICAL SOC WASHINGTON PI LAWRENCE PA C/O ALLEN PRESS INC, 1041 NEW HAMPSHIRE ST, ACCT# 141866, LAWRENCE, KS 66044 USA SN 1525-2647 EI 1938-2952 J9 COMP PARASITOL JI Comp. Parasitol. PD JUL PY 2014 VL 81 IS 2 BP 291 EP 294 PG 4 WC Parasitology; Zoology SC Parasitology; Zoology GA AM9WC UT WOS:000340230700024 ER PT J AU Keyser, BM Andres, DK Holmes, WW Paradiso, D Appell, A Letukas, VA Benton, B Clark, OE Gao, XG Ray, P Anderson, DR Ray, R AF Keyser, Brian M. Andres, Devon K. Holmes, Wesley W. Paradiso, Danielle Appell, Ashley Letukas, Valerie A. Benton, Betty Clark, Offie E. Gao, Xiugong Ray, Prabhati Anderson, Dana R. Ray, Radharaman TI Mustard Gas Inhalation Injury: Therapeutic Strategy SO INTERNATIONAL JOURNAL OF TOXICOLOGY LA English DT Review DE sulfur mustard; inhalation; apoptosis; antioxidants; anti-inflammatory; protease ID ACUTE LUNG INJURY; 2-CHLOROETHYL ETHYL SULFIDE; EPITHELIAL-CELL APOPTOSIS; INHALED SULFUR MUSTARD; NITRIC-OXIDE SYNTHASE; ACETYL-L-CYSTEINE; GUINEA-PIGS; FAS LIGAND; OXIDATIVE STRESS; PULMONARY-FIBROSIS AB Mustard gas (sulfur mustard [SM], bis-[2-chloroethyl] sulfide) is a vesicating chemical warfare agent and a potential chemical terrorism agent. Exposure of SM causes debilitating skin blisters (vesication) and injury to the eyes and the respiratory tract; of these, the respiratory injury, if severe, may even be fatal. Therefore, developing an effective therapeutic strategy to protect against SM-induced respiratory injury is an urgent priority of not only the US military but also the civilian antiterrorism agencies, for example, the Homeland Security. Toward developing a respiratory medical countermeasure for SM, four different classes of therapeutic compounds have been evaluated in the past: anti-inflammatory compounds, antioxidants, protease inhibitors and antiapoptotic compounds. This review examines all of these different options; however, it suggests that preventing cell death by inhibiting apoptosis seems to be a compelling strategy but possibly dependent on adjunct therapies using the other drugs, that is, anti-inflammatory, antioxidant, and protease inhibitor compounds. C1 [Keyser, Brian M.; Andres, Devon K.; Appell, Ashley; Letukas, Valerie A.; Benton, Betty; Clark, Offie E.; Ray, Radharaman] US Army Med Res Inst Chem Def, Div Res, Aberdeen Proving Ground, MD USA. [Holmes, Wesley W.; Paradiso, Danielle; Anderson, Dana R.] US Army Med Res Inst Chem Def, Analyt Toxicol Div, Aberdeen Proving Ground, MD USA. [Gao, Xiugong; Ray, Prabhati] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. RP Ray, R (reprint author), US Army Med Res Inst Chem Def, Div Res, Cellular & Mol Biol Branch, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM radharaman.ray.civ@mail.mil OI Andres, Devon/0000-0002-6823-4132 FU Defense Threat Reduction Agency-Joint Science and Technology Office, Medical ST Division [CBM.RESP.01.10.RC.015] FX This work was supported by the Defense Threat Reduction Agency-Joint Science and Technology Office, Medical S&T Division [Grant CBM.RESP.01.10.RC.015]. Additionally, this research was supported in part by an appointment to the Postgraduate Research Participation Program at the US Army Medical Research Institute of Chemical Defense administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and USAMRMC. We acknowledge LTC Derron A. Alves for his expertise in the lung cast staining. NR 91 TC 6 Z9 6 U1 1 U2 25 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1091-5818 EI 1092-874X J9 INT J TOXICOL JI Int. J. Toxicol. PD JUL-AUG PY 2014 VL 33 IS 4 BP 271 EP 281 DI 10.1177/1091581814532959 PG 11 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA AN4GK UT WOS:000340545500003 PM 24801489 ER PT J AU Peng, LS Adler, M Demogines, A Borrell, A Liu, HS Tao, L Tepp, WH Zhang, SC Johnson, EA Sawyer, SL Dong, M AF Peng, Lisheng Adler, Michael Demogines, Ann Borrell, Andrew Liu, Huisheng Tao, Liang Tepp, William H. Zhang, Su-Chun Johnson, Eric A. Sawyer, Sara L. Dong, Min TI Widespread Sequence Variations in VAMP1 across Vertebrates Suggest a Potential Selective Pressure from Botulinum Neurotoxins SO PLOS PATHOGENS LA English DT Article ID PERIPHERAL NERVOUS-SYSTEM; MEMBRANE-PROTEIN; RAT-BRAIN; NEUROTRANSMITTER RELEASE; SYNAPTOBREVIN-I; MOTOR-NEURONS; R-SNARES; EXOCYTOSIS; PATTERNS; CLEAVAGE AB Botulinum neurotoxins (BoNT/A-G), the most potent toxins known, act by cleaving three SNARE proteins required for synaptic vesicle exocytosis. Previous studies on BoNTs have generally utilized the major SNARE homologues expressed in brain (VAMP2, syntaxin 1, and SNAP-25). However, BoNTs target peripheral motor neurons and cause death by paralyzing respiratory muscles such as the diaphragm. Here we report that VAMP1, but not VAMP2, is the SNARE homologue predominantly expressed in adult rodent diaphragm motor nerve terminals and in differentiated human motor neurons. In contrast to the highly conserved VAMP2, BoNT-resistant variations in VAMP1 are widespread across vertebrates. In particular, we identified a polymorphism at position 48 of VAMP1 in rats, which renders VAMP1 either resistant (I48) or sensitive (M48) to BoNT/D. Taking advantage of this finding, we showed that rat diaphragms with I48 in VAMP1 are insensitive to BoNT/D compared to rat diaphragms with M48 in VAMP1. This unique intra-species comparison establishes VAMP1 as a physiological toxin target in diaphragm motor nerve terminals, and demonstrates that the resistance of VAMP1 to BoNTs can underlie the insensitivity of a species to members of BoNTs. Consistently, human VAMP1 contains I48, which may explain why humans are insensitive to BoNT/D. Finally, we report that residue 48 of VAMP1 varies frequently between M and I across seventeen closely related primate species, suggesting a potential selective pressure from members of BoNTs for resistance in vertebrates. C1 [Peng, Lisheng; Tao, Liang; Dong, Min] Harvard Univ, Dept Microbiol & Immunobiol, Sch Med, Southborough, MA 01772 USA. [Peng, Lisheng; Tao, Liang; Dong, Min] New England Primate Res Ctr, Div Neuroscience, Southborough, MA USA. [Adler, Michael; Borrell, Andrew] US Army Med Res Inst Chem Def, Neurobehav Toxicol Branch, Aberdeen Proving Ground, MD USA. [Demogines, Ann; Sawyer, Sara L.] Univ Texas Austin, Dept Mol Biosci, Austin, TX 78712 USA. [Liu, Huisheng; Zhang, Su-Chun] Univ Wisconsin, Dept Neurol, Waisman Ctr, Dept Neurosci, Madison, WI 53706 USA. [Tepp, William H.; Johnson, Eric A.] Univ Wisconsin, Dept Bacteriol, Madison, WI 53706 USA. RP Peng, LS (reprint author), Harvard Univ, Dept Microbiol & Immunobiol, Sch Med, Southborough, MA 01772 USA. EM michael.adler2.civ@mail.mil; saras@austin.utexas.edu; min_dong@hms.harvard.edu FU NIH [RR000168, OD011103, 1R56AI097834, 1R21NS082830, 1R01NS080833, R01-GM-093086]; American Cancer Society; Burroughs Wellcome Fund FX This study was supported by the following NIH grants: RR000168 and OD011103 (to the New England Primate Research Center), 1R56AI097834, 1R21NS082830, and 1R01NS080833 (to MD), R01-GM-093086 (to SLS). AD is supported by an American Cancer Society Postdoctoral Fellowship. SLS holds a Career Award in the Biomedical Sciences from the Burroughs Wellcome Fund. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 35 TC 6 Z9 6 U1 1 U2 5 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-7366 EI 1553-7374 J9 PLOS PATHOG JI PLoS Pathog. PD JUL PY 2014 VL 10 IS 7 AR e1004177 DI 10.1371/journal.ppat.1004177 PG 9 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA AN4IL UT WOS:000340551000006 PM 25010769 ER PT J AU Olcese, SP Derosa, R Kern, SQ Lustik, MB Sterbis, JR McMann, LP AF Olcese, S. P. Derosa, R. Kern, S. Q. Lustik, M. B. Sterbis, J. R. McMann, L. P. TI Comparison of outcomes after TURP versus photoselective vaporization of the prostate with respect to trainee involvement utilizing ACS NSQIP SO PROSTATE CANCER AND PROSTATIC DISEASES LA English DT Article ID HOLMIUM LASER ENUCLEATION; RANDOMIZED CLINICAL-TRIAL; EFFECT SURGICAL TIMES; TRANSURETHRAL RESECTION; RESIDENT INVOLVEMENT; UNCOMPLICATED APPENDICITIS; LAPAROSCOPIC APPENDECTOMY; COMPLICATION RATES; FOLLOW-UP; HYPERPLASIA AB BACKGROUND: Large Multicenter studies comparing outcomes between TURP and photoselective vaporization of the prostate (PVP) are sparse, with no studies having compared the influence of trainee involvement on these outcomes. Our objectives were to assess 30-day outcomes after TURP and PVP with respect to trainee involvement using an independent national surgical database. METHODS: Using the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) data (2005-2011), 7893 men were identified who underwent TURP or PVP. Regression models were constructed to assess associations between surgical approach, risk-adjusted morbidity and individual complications. Relationships between operative approach, operative duration and duration of stay were also examined and subdivided based upon trainee level. RESULTS: Of 7893 patients, 4950 (62.7%) underwent TURP and 2943 (37.3%) underwent PVP. TURP patients were older, more likely to have diabetes, cancer, history of steroid use and preoperative transfusion compared with PVP patients, who were more likely to have coronary artery disease or bleeding disorders. Risk-adjusted overall morbidity was similar; however, PVP was associated with less pneumonia (0.2% vs 0.5%, P<0.015), bleeding requiring transfusion (0.5% vs 1.8%, P<0.001) and return to the operating room (1.5% vs 2.2%, P<0.022). PVP patients also had shorter length of stay (0.8 vs 2.1 days, P<0.001). There were no significant differences in outcomes when a trainee was involved. Operative duration was similar for TURP and PVP when performed by an attending alone (52 vs 52 min, P<0.001), but was longer with trainee involvement, regardless of post-graduate year (PGY) level (P<0.001). Comparison of operative duration among trainee subgroups demonstrated longer operative times for the PGY 6-9 subgroup performing PVP when compared with other subgroups (P<0.003). CONCLUSIONS: Within ACS NSQIP hospitals, TURP and PVP demonstrated similar risk-adjusted overall morbidity. Despite longer operative times for TURP and PVP with trainee involvement, there were no significant differences in outcomes. C1 [Olcese, S. P.; Derosa, R.; Kern, S. Q.; Sterbis, J. R.; McMann, L. P.] Tripler Army Med Ctr, Dept Surg, Urol Serv, Honolulu, HI 96859 USA. [Lustik, M. B.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. RP Olcese, SP (reprint author), Tripler Army Med Ctr, Dept Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM Seth.P.Olcese.mil@us.army.mil NR 21 TC 1 Z9 1 U1 1 U2 3 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1365-7852 EI 1476-5608 J9 PROSTATE CANCER P D JI Prostate Cancer Prostatic Dis. PD JUL PY 2014 VL 17 IS 3 BP 227 EP 232 DI 10.1038/pcan.2014.13 PG 6 WC Oncology; Urology & Nephrology SC Oncology; Urology & Nephrology GA AN3UL UT WOS:000340514100003 PM 24732080 ER PT J AU Zhang, SS AF Zhang, Sheng S. TI Understanding of Sulfurized Polyacrylonitrile for Superior Performance Lithium/Sulfur Battery SO ENERGIES LA English DT Article DE lithium-sulfur battery; sulfur cathode; sulfurized carbon; sulfurized polyacrylonitrile; polysulfide ID COMPOSITE CATHODE MATERIALS; CARBONATE-BASED ELECTROLYTE; ELECTROCHEMICAL PERFORMANCE; CHARGE/DISCHARGE CHARACTERISTICS; POLYMER ELECTROLYTE; LI/S BATTERIES; CAPACITY; GRAPHENE; STORAGE; CYCLE AB Sulfurized polyacrylonitrile (SPAN) is one of the most important sulfurized carbon materials that can potentially be coupled with the carbonaceous anode to fabricate a safe and low cost "all carbon" lithium-ion battery. However, its chemical structure and electrochemical properties have been poorly understood. In this discussion, we analyze the previously published data in combination with our own results to propose a more reasonable chemical structure that consists of short -S-x- chains covalently bonded onto cyclized, partially dehydrogenated, and ribbon-like polyacrylonitrile backbones. The proposed structure fits all previous structural characterizations and explains many unique electrochemical phenomena that were observed from the Li/SPAN cells but have not been understood clearly. C1 US Army Res Lab, Electrochem Branch, RDRL SED C, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), US Army Res Lab, Electrochem Branch, RDRL SED C, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. EM shengshui.zhang.civ@mail.mil RI Zhang, Sheng/A-4456-2012 OI Zhang, Sheng/0000-0003-4435-4110 NR 32 TC 19 Z9 19 U1 13 U2 122 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1996-1073 J9 ENERGIES JI Energies PD JUL PY 2014 VL 7 IS 7 BP 4588 EP 4600 DI 10.3390/en7074588 PG 13 WC Energy & Fuels SC Energy & Fuels GA AM6QH UT WOS:000339989200031 ER PT J AU Valenti, MC Torrieri, D Talarico, S AF Valenti, Matthew C. Torrieri, Don Talarico, Salvatore TI A Direct Approach to Computing Spatially Averaged Outage Probability SO IEEE COMMUNICATIONS LETTERS LA English DT Article DE Outage probability; stochastic geometry; point processes; interference modeling; fading ID WIRELESS NETWORKS AB This letter describes a direct method for computing the spatially averaged outage probability of a network with interferers located according to a point process and signals subject to fading. Unlike most common approaches, it does not require transforms such as a Laplace transform. Examples show how to directly obtain the outage probability in the presence of Rayleigh fading in networks whose interferers are drawn from binomial and Poisson point processes defined over arbitrary regions. We furthermore show that, by extending the arbitrary region to the entire plane, the result for Poisson point processes converges to the same expression found by Baccelli et al. C1 [Valenti, Matthew C.; Talarico, Salvatore] W Virginia Univ, Morgantown, WV 26506 USA. [Torrieri, Don] US Army Res Lab, Adelphi, MD 20783 USA. RP Valenti, MC (reprint author), W Virginia Univ, Morgantown, WV 26506 USA. EM valenti@ieee.org; don.j.torrieri.civ@mail.mil; Salvatore.Talarico81@gmail.com OI Valenti, Matthew/0000-0001-6089-0509 NR 11 TC 4 Z9 5 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1089-7798 EI 1558-2558 J9 IEEE COMMUN LETT JI IEEE Commun. Lett. PD JUL PY 2014 VL 18 IS 7 BP 1103 EP 1106 DI 10.1109/LCOMM.2014.2317740 PG 4 WC Telecommunications SC Telecommunications GA AM8IE UT WOS:000340116100004 ER PT J AU Zheng, Q Cao, GH La Porta, TF Swami, A AF Zheng, Qiang Cao, Guohong La Porta, Thomas F. Swami, Ananthram TI Cross-Layer Approach for Minimizing Routing Disruption in IP Networks SO IEEE TRANSACTIONS ON PARALLEL AND DISTRIBUTED SYSTEMS LA English DT Article DE Routing; failures; cross-layer; recovery; IP networks ID WDM-BASED NETWORKS; FAILURES; DESIGN; PATH; PROTECTION; RECOVERY; BACKBONE; SCHEME AB Backup paths are widely used in IP networks to protect IP links from failures. However, existing solutions such as the commonly used independent model and Shared Risk Link Group (SRLG) model do not accurately reflect the correlation between IP link failures, and thus may not choose reliable backup paths. We propose a cross-layer approach for minimizing routing disruption caused by IP link failures. We develop a probabilistically correlated failure (PCF) model to quantify the impact of IP link failure on the reliability of backup paths. With the PCF model, we propose an algorithm to choose multiple reliable backup paths to protect each IP link. When an IP link fails, its traffic is split onto multiple backup paths to ensure that the rerouted traffic load on each IP link does not exceed the usable bandwidth. We evaluate our approach using real ISP networks with both optical and IP layer topologies. Experimental results show that two backup paths are adequate for protecting a logical link. Compared with existing works, the backup paths selected by our approach are at least 18 percent more reliable and the routing disruption is reduced by at least 22 percent. Unlike prior works, the proposed approach prevents the rerouted traffic from interfering with normal traffic. C1 [Zheng, Qiang] Penn State Univ, Dept Comp Sci & Engn, University Pk, PA 16802 USA. [Cao, Guohong] Penn State Univ, Dept Comp Sci, University Pk, PA 16802 USA. [La Porta, Thomas F.] Penn State Univ, EIC, University Pk, PA 16802 USA. [Swami, Ananthram] Army Res Lab, Adelphi, MA USA. RP Zheng, Q (reprint author), Penn State Univ, Dept Comp Sci & Engn, University Pk, PA 16802 USA. NR 38 TC 1 Z9 2 U1 0 U2 3 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1045-9219 EI 1558-2183 J9 IEEE T PARALL DISTR JI IEEE Trans. Parallel Distrib. Syst. PD JUL PY 2014 VL 25 IS 7 BP 1659 EP 1669 DI 10.1109/TPDS.2013.157 PG 11 WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA AN0NX UT WOS:000340282400001 ER PT J AU Fazel, K Scharffenberg, WA Bombardelli, FA AF Fazel, Khalida Scharffenberg, William A. Bombardelli, Fabian A. TI Assessment of the Melt Rate Function in a Temperature Index Snow Model Using Observed Data SO JOURNAL OF HYDROLOGIC ENGINEERING LA English DT Article DE Melt rate; Snowmelt modeling; Hydrologic Engineering Center's hydrologic modeling system (HEC-HMS); Error propagation; Antecedent temperature index-melt rate (ATIMR); Antecedent temperature index; Streamflow synthesis and reservoir regulation (SSARR) model; American River Watershed; Rainfall-runoff modeling; Snow water equivalent AB Temperature index snowmelt models often require representation of a snowpack's melt rate. Defining the melt rate as a function of an accumulated number of warming degree-days is achieved in some temperature index models through the antecedent temperature index-melt rate (ATIMR) function, and provides a reasonable method for adjusting the melt rate during the season. Modelers have typically relied on a default ATIMR function developed two decades ago. However, literature concerning the nature of this default function and how it was developed is largely nonexistent. This paper presents results of a comparison between the default ATIMR function and ATIMR functions computed from field data from two headwater stations within the American River watershed upstream of Folsom Lake, California. An error analysis was also performed using the site-specific data. Using the Hydrologic Engineering Center's hydrologic modeling system (HEC-HMS), it was found that modeled results often varied dramatically between the default curve and the computed curves. In one case, modeled results showed significant improvement between the default method and that of the data-derived approach. This finding suggests that conventional use of the default 1991 curve, often employed in practice irrespective of season and/or location, should at the very least be reconsidered. (C) 2014 American Society of Civil Engineers. C1 [Fazel, Khalida] GEI Consultants Inc, Rancho Cordova, CA 95670 USA. [Fazel, Khalida; Bombardelli, Fabian A.] Univ Calif Davis, Dept Civil & Environm Engn, Davis, CA 95616 USA. [Scharffenberg, William A.] US Army, Corps Engineers, Hydrol Engn Ctr, Davis, CA 95616 USA. RP Scharffenberg, WA (reprint author), US Army, Corps Engineers, Hydrol Engn Ctr, 609 Second St, Davis, CA 95616 USA. EM kfazel@geiconsultants.com; wscharffenberg@gmail.com; fabombardelli@ucdavis.edu NR 8 TC 0 Z9 0 U1 2 U2 14 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1084-0699 EI 1943-5584 J9 J HYDROL ENG JI J. Hydrol. Eng. PD JUL PY 2014 VL 19 IS 7 BP 1275 EP 1282 DI 10.1061/(ASCE)HE.1943-5584.0000925 PG 8 WC Engineering, Civil; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA AM8XW UT WOS:000340163600001 ER PT J AU Singh, VP Byrd, A Cui, HJ AF Singh, Vijay P. Byrd, Aaron Cui, Huijuan TI Flow Duration Curve Using Entropy Theory SO JOURNAL OF HYDROLOGIC ENGINEERING LA English DT Article DE Duration curves; Flow duration curve; Lagrange multipliers; Principle of maximum entropy; Shannon entropy AB Using the entropy theory, this study derives a function for modeling the flow duration curve (FDC) based on two equations that form simple constraints: (1) the total probability of all flow discharges, and (2) the mean discharge. Parameters of the derived curve are determined from the entropy theory with the use of these two constraints. For deriving the flow duration curve by the entropy theory, a nonlinear cumulative distribution function is assumed, which is tested using observed flow data. The derived flow duration curves are tested using field data and are found to be in agreement with observed curves. With the entropy parameter determined for each station, the flow duration curve can also be forecasted for different recurrence intervals. The main advantage of the use of the entropy theory-based FDCs is that the parameters are based on observations, and hence no fitting is needed. Second, the theory permits a probabilistic characterization of the flow duration curve and hence the probability density function underlying the curve. It also permits a quantitative assessment of the uncertainty of the flow duration curve. Additional work is needed to regionalize the FDC parameters. (C) 2014 American Society of Civil Engineers. C1 [Singh, Vijay P.] Texas A&M Univ, Dept Biol & Agr Engn, Dept Civil & Environm Engn, College Stn, TX 77843 USA. [Byrd, Aaron] US Army, Corps Engineers, Hydrol Syst Branch, Coastal & Hydraul Lab,Engineer Res Dev Ctr, Vicksburg, MS 39181 USA. [Cui, Huijuan] Texas A&M Univ, Water Management & Hydrol Sci Program, College Stn, TX 77843 USA. RP Cui, HJ (reprint author), Texas A&M Univ, Water Management & Hydrol Sci Program, College Stn, TX 77843 USA. EM cui.huijuan@gmail.com NR 17 TC 2 Z9 2 U1 0 U2 7 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1084-0699 EI 1943-5584 J9 J HYDROL ENG JI J. Hydrol. Eng. PD JUL PY 2014 VL 19 IS 7 BP 1340 EP 1348 DI 10.1061/(ASCE)HE.1943-5584.0000930 PG 9 WC Engineering, Civil; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA AM8XW UT WOS:000340163600007 ER PT J AU Schultz, MK Wright, LKM Furtado, MD Stone, MF Moffett, MC Kelley, NR Bourne, AR Lumeh, WZ Schultz, CR Schwartz, JE Lumley, LA AF Schultz, M. K. Wright, L. K. M. Furtado, M. de Araujo Stone, M. F. Moffett, M. C. Kelley, N. R. Bourne, A. R. Lumeh, W. Z. Schultz, C. R. Schwartz, J. E. Lumley, L. A. TI Caramiphen edisylate as adjunct to standard therapy attenuates soman-induced seizures and cognitive deficits in rats SO NEUROTOXICOLOGY AND TERATOLOGY LA English DT Article DE Soman; Caramiphen; Anticonvulsant; Behavior; Chemical warfare nerve agents; Rats ID HIPPOCAMPAL PYRAMIDAL NEURONS; AGENT-INDUCED SEIZURE; SIGMA-SITE LIGANDS; ANTICHOLINERGIC DRUGS; BASOLATERAL AMYGDALA; MECHANISMS; HYPOTHERMIA; EFFICACY; NEUROPATHOLOGY; PRETREATMENT AB The progression of epileptiform activity following soman (GD) exposure is characterized by a period of excessive cholinergic activity followed by excessive glutamatergic activity resulting in status epilepticus, which may lead to neuropathological damage and behavioral deficits. Caramiphen edisylate is an anticholinergic drug with antiglutamatergic properties, which conceptually may be a beneficial therapeutic approach to the treatment of nerve agent exposure. In the present study, rats were exposed to 1.2 LD50 GD or saline, treated with atropine sulfate (2 mg/kg, im) and HI-6 (93.6 mg/kg, im) 1 min after GD exposure, and monitored for seizure activity. Rats were treated with diazepam (10 mg/kg, sc) and caramiphen (0, 20 or 100 mg/kg, im) 30 min after seizure onset. Following GD exposure, performance was evaluated using a battery of behavioral tests to assess motor coordination and function, sensorimotor gating, and cognitive function. Caramiphen as adjunct to diazepam treatment attenuated GD-induced seizure activity, neuropathological damage, and cognitive deficits compared to diazepam alone, but did not attenuate the GD-induced sensorimotor gating impairment. These findings show that physiological, behavioral, and neuropathological effects of GD exposure can be attenuated by treatment with caramiphen as an adjunct to therapy, even if administration is delayed to 30 min after seizure onset. Published by Elsevier Inc. C1 [Schultz, M. K.; Wright, L. K. M.; Stone, M. F.; Moffett, M. C.; Kelley, N. R.; Bourne, A. R.; Lumeh, W. Z.; Schultz, C. R.; Schwartz, J. E.; Lumley, L. A.] US Army, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. [Furtado, M. de Araujo] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Lumley, LA (reprint author), US Army, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM lucille.a.lange.civ@mail.mil FU Medical S&T Division & Physical Science Division [CBM.NEURO.01.10.RC.007]; Defense Threat Reduction Agency-Jiont Science and Technology Office FX This research was supported by the Defense Threat Reduction Agency-Jiont Science and Technology Office, Medical S&T Division & Physical Science Division (PI: Dr. Lucille Lumley, grant #: CBM.NEURO.01.10.RC.007). Dr. Linnzi Wright, Mark Schultz, Caroline Schultz and Andrew Bourne were supported by appointments to the Student/Postdoctoral Research Participation Program at the U.S. Army Medical Research Institute of Chemical Defense administered by the Oak Ridge Institute for Science and Education through an interagency appointment between the U.S. Department of Energy and USAMRMC. NR 54 TC 2 Z9 2 U1 1 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0892-0362 EI 1872-9738 J9 NEUROTOXICOL TERATOL JI Neurotoxicol. Teratol. PD JUL-AUG PY 2014 VL 44 BP 89 EP 104 DI 10.1016/j.ntt.2014.06.002 PG 16 WC Neurosciences; Toxicology SC Neurosciences & Neurology; Toxicology GA AN0VL UT WOS:000340302000010 PM 24946037 ER PT J AU Boylan, GL Cho, BR AF Boylan, Gregory L. Cho, Byung Rae TI Solving the Multidisciplinary Robust Parameter Design Problem for Mixed Type Quality Characteristics under Asymmetric Conditions SO QUALITY AND RELIABILITY ENGINEERING INTERNATIONAL LA English DT Article DE quality; multidisciplinary robust parameter design; mixed quality characteristics; goal programming; skew normal distribution ID RESPONSE-SURFACE OPTIMIZATION; PROCESS CAPABILITY; OPTIMUM PROCESS; DISTRIBUTIONS; MODEL; SPECIFICATIONS; RELIABILITY; PRECISION; FRAMEWORK; TAGUCHI AB Quality practitioners often identify robust parameter design (RPD) as one of the most important and effective methods for process and quality improvement. Within this framework, identifying the optimal factor settings that achieve desired process targets with minimum variance is critical and can translate to significant reductions in product waste and processing costs. In solving this problem, most traditional RPD models consider only a single quality characteristic of interest. However, products are often judged by multiple quality characteristics, which often have conflicting objectives. Conventional RPD models that address the multi-response problem typically only examine like-type cases, and those that consider mixed types of quality characteristics often overlook any asymmetry that is likely to exist in certain types. In contrast, this article proposes a multidisciplinary RPD methodology that provides an enhanced approach for modeling multiple, mixed type quality characteristics; uses the skew normal distribution to allow for a fuller and more accurate representation of asymmetric system properties and to facilitate simultaneous modeling of both symmetric and asymmetric conditions; and implements a priority-based optimization scheme that affords engineers' and decision makers' flexibility in establishing and modifying optimization priorities. A numerical example is used to demonstrate the proposed methodology, and the results are compared traditional approaches to illustrate potential improvements. Copyright (c) 2013 John Wiley & Sons, Ltd. C1 [Boylan, Gregory L.] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. [Cho, Byung Rae] Clemson Univ, Dept Ind Engn, Adv Qual Engn Lab, Clemson, SC 29634 USA. RP Boylan, GL (reprint author), US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. EM boylangc@earthlink.net NR 61 TC 1 Z9 1 U1 1 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0748-8017 EI 1099-1638 J9 QUAL RELIAB ENG INT JI Qual. Reliab. Eng. Int. PD JUL PY 2014 VL 30 IS 5 BP 681 EP 695 DI 10.1002/qre.1520 PG 15 WC Engineering, Multidisciplinary; Engineering, Industrial; Operations Research & Management Science SC Engineering; Operations Research & Management Science GA AN0OW UT WOS:000340284900008 ER PT J AU Fox, GA Felice, RG Midgley, TL Wilson, GV Al-Madhhachi, AST AF Fox, Garey A. Felice, Rachel G. Midgley, Taber L. Wilson, Glenn V. Al-Madhhachi, Abdul-Sahib T. TI Laboratory soil piping and internal erosion experiments: evaluation of a soil piping model for low-compacted soils SO EARTH SURFACE PROCESSES AND LANDFORMS LA English DT Article DE groundwater seepage; internal erosion; jet erosion test; piping; soil erodibility ID SEEPAGE EROSION; ERODIBILITY; SEDIMENT; PIPEFLOW; PREDICTION; STABILITY; FAILURE; SCOUR; TESTS; FLOW AB Mechanistic models have been proposed for soil piping and internal erosion on well-compacted levees and dams, but limited research has evaluated these models in less compacted (more erodible) soils typical of hillslopes and streambanks. This study utilized a soil box (50 cm long, 50 cm wide and 20 cm tall) to conduct constant-head, soil pipe and internal erosion experiments for two soils (clay loam from Dry Creek and sandy loam from Cow Creek streambanks) packed at uniform bulk densities. Initial gravimetric moisture contents prior to packing were 10, 12 and 14% for Dry Creek soil and 8, 12, and 14% for Cow Creek soil. A 1-cm diameter rod was placed horizontally along the length of the soil bed during packing and carefully removed after packing to create a continuous soil pipe. A constant head was maintained at the inflow end. Flow rates and sediment concentrations were measured from the pipe outlet. Replicate submerged jet erosion tests (JETs) were conducted to derive erodibility parameters for repacked samples at the same moisture contents. Flow rates from the box experiments were used to calibrate the mechanistic model. The influence of the initial moisture content was apparent, with some pipes (8% moisture content) expanding so fast that limited data was collected. The mechanistic model was able to estimate equivalent flow rates to those observed in the experiments, but had difficulty matching observed sediment concentrations when the pipes rapidly expanded. The JETs predicted similar erodibility coefficients compared to the mechanistic model for the more erodible cases but not for the less erodible cases (14% moisture content). Improved models are needed that better define the changing soil pipe cross-section during supply-and transport-limited internal erosion, especially for piping through lower compacted (more erodible) soils as opposed to more well-compacted soils resulting from constructing levees and dams. Copyright (C) 2013 John Wiley & Sons, Ltd. C1 [Fox, Garey A.; Felice, Rachel G.] Oklahoma State Univ, Stillwater, OK 74078 USA. [Felice, Rachel G.] US Army Corps Engineers, Tulsa, OK USA. [Midgley, Taber L.] Civil & Environm Consultants Inc, Raynham, MA USA. [Wilson, Glenn V.] ARS, USDA, Natl Sedimentat Lab, Oxford, MS USA. [Al-Madhhachi, Abdul-Sahib T.] Al Mustansiriya Univ, Coll Engn, Dept Environm Engn, Baghdad, Iraq. RP Fox, GA (reprint author), Oklahoma State Univ, 120 Agr Hall, Stillwater, OK 74078 USA. EM garey.fox@okstate.edu FU National Science Foundation (NSF) [0943491]; NSF FX This material is based upon work supported by the National Science Foundation (NSF) under Grant No. 0943491 and a NSF Graduate Research Fellowship. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the NSF. The authors acknowledge Mr David Criswell and Mrs Kelsey Criswell for performing soil characterization tests. NR 37 TC 1 Z9 1 U1 4 U2 35 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0197-9337 EI 1096-9837 J9 EARTH SURF PROC LAND JI Earth Surf. Process. Landf. PD JUL PY 2014 VL 39 IS 9 BP 1137 EP 1145 DI 10.1002/esp.3508 PG 9 WC Geography, Physical; Geosciences, Multidisciplinary SC Physical Geography; Geology GA AL9BW UT WOS:000339435600001 ER PT J AU Goldman, SB AF Goldman, Sarah B. TI Avoiding common statistical pitfalls SO JOURNAL OF HAND THERAPY LA English DT Editorial Material C1 US Army Med Res & Mat Command, Ft Detrick, MD 21702 USA. RP Goldman, SB (reprint author), US Army Med Res & Mat Command, Ft Detrick, MD 21702 USA. EM sarah.b.goldman.mil@mail.mil NR 2 TC 0 Z9 0 U1 0 U2 0 PU HANLEY & BELFUS-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0894-1130 EI 1545-004X J9 J HAND THER JI J. Hand Ther. PD JUL-SEP PY 2014 VL 27 IS 3 BP 163 EP 164 DI 10.1016/j.jht.2013.09.004 PG 2 WC Orthopedics; Rehabilitation; Surgery SC Orthopedics; Rehabilitation; Surgery GA AM3VI UT WOS:000339780500001 PM 24100057 ER PT J AU Yalamanchili, C Manda, VK Chittiboyina, AG HarrellJr, WA Webb, RP Khan, IA AF Yalamanchili, C. Manda, V. K. Chittiboyina, A. G. HarrellJr, W. A. Webb, R. P. Khan, I. A. TI Identification of novel phytochemical inhibitors of botulinum neurotoxin A SO PLANTA MEDICA LA English DT Meeting Abstract CT 55th Annual Meeting of the American-Society-of-Pharmacognosy (ASP) CY AUG 02-06, 2014 CL Oxford, MS SP Amer Soc Pharmacognosy C1 [Yalamanchili, C.; Manda, V. K.; Chittiboyina, A. G.; Khan, I. A.] Univ Mississippi, Pharmaceut Sci Res Inst, Natl Ctr Nat Prod Res, University, MS 38677 USA. [Yalamanchili, C.; Khan, I. A.] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, University, MS 38677 USA. [HarrellJr, W. A.; Webb, R. P.] US Army Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Khan, I. A.] King Saud Univ, Coll Pharm, Dept Pharmacognosy, Riyadh, Saudi Arabia. NR 0 TC 0 Z9 0 U1 0 U2 0 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 0032-0943 EI 1439-0221 J9 PLANTA MED JI Planta Med. PD JUL PY 2014 VL 80 IS 10 MA PH13 BP 821 EP 821 PG 1 WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary Medicine; Pharmacology & Pharmacy SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary Medicine GA AM3VP UT WOS:000339781200332 ER PT J AU Alam, R Lightcap, IV Karwacki, CJ Kamat, PV AF Alam, Rabeka Lightcap, Ian V. Karwacki, Christopher J. Kamat, Prashant V. TI Sense and Shoot: Simultaneous Detection and Degradation of Low-Level Contaminants Using Graphene-Based Smart Material Assembly SO ACS NANO LA English DT Article DE graphene oxide; photocatalysis; SERS detection; environmental remediation; nitro compounds; TiO2 ID OXIDE; NANOPARTICLES; EXPLOSIVES; FLUORESCENCE; METALS; RDX; TNT AB Smart material nanoassemblies that can simultaneously sense and shoot low-level contaminants from air and water are important for overcoming the threat of hazardous chemicals. Graphene oxide (GO) sheets deposited on mesoscopic TiO2 films that underpin the deposition of Ag nanoparticles with UV irradiation provide the foundation for the design of a smart material. The Ag particle size Is readily controlled through precursor concentration and UV irradiation time. These semiconductor graphene oxide-metal (SGM) films are SERS-active and hence capable of sensing aromatic contaminants such as 4-nitrobenzenethiol (4-NBT) in nanomolar range. Increased local concentration of organic molecules achieved through interaction with 2-D carbon support (GO) facilitates low-level detection of contaminants. Upon UV irradiation of 4-NBT-loaded SGM film, one can induce photocatalytic transformations. Thus, each component of the SGM film plays a pivotal role in aiding the detection and degradation of a contaminant dispersed in aqueous solutions. The advantage of using SGM films as multipurpose "detect and destroy" systems for nitroaromatic molecules is discussed. C1 [Alam, Rabeka; Lightcap, Ian V.; Kamat, Prashant V.] Univ Notre Dame, Radiat Lab, Notre Dame, IN 46556 USA. [Kamat, Prashant V.] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA. [Lightcap, Ian V.] Univ Notre Dame, Ctr Sustainable Energy Notre Dame, Notre Dame, IN 46556 USA. [Karwacki, Christopher J.] US Army Res Dev & Engn Command, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Kamat, PV (reprint author), Univ Notre Dame, Radiat Lab, Notre Dame, IN 46556 USA. EM pkamat@nd.edu FU Army Research Office [ARO 64011-CH]; Division of Chemical Sciences, Geosciences, and Biosciences, Office of Basic Energy Sciences of the U.S. Department of Energy [DE-FC02-04ER15533] FX The research described in this paper is supported by the Army Research Office through the award ARO 64011-CH. This is a document number 5022 from the Notre Dame Radiation Laboratory, which is supported by the Division of Chemical Sciences, Geosciences, and Biosciences, Office of Basic Energy Sciences of the U.S. Department of Energy through award DE-FC02-04ER15533. NR 34 TC 16 Z9 16 U1 21 U2 167 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1936-0851 EI 1936-086X J9 ACS NANO JI ACS Nano PD JUL PY 2014 VL 8 IS 7 BP 7272 EP 7278 DI 10.1021/nn502336x PG 7 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA AL9LR UT WOS:000339463100084 PM 24893206 ER PT J AU DeGregorio, BA Chiavacci, SJ Weatherhead, PJ Willson, JD Benson, TJ Sperry, JH AF DeGregorio, Brett A. Chiavacci, Scott J. Weatherhead, Patrick J. Willson, John D. Benson, Thomas J. Sperry, Jinelle H. TI Snake predation on North American bird nests: culprits, patterns and future directions SO JOURNAL OF AVIAN BIOLOGY LA English DT Review ID BLACK RAT SNAKES; SONGBIRD NESTS; HABITAT USE; REPRODUCTIVE SUCCESS; VIDEO IDENTIFICATION; SEASONAL-VARIATION; PREY INTERACTIONS; ELAPHE-OBSOLETA; GRASSLAND BIRDS; MOVEMENTS AB Predation is the leading cause of nest failure for most birds. Thus, for ornithologists interested in the causes and consequences of variation in nest success, knowing the identity and understanding the behavior of dominant nest predators is likely to be important. Video documentation of nests has shown that snakes are frequent predators. Here we reviewed 53 North American studies that used nest cameras and used these data to identify broad patterns in snake predation. Snakes accounted for 26% (range: 0-90%) of recorded predation events, with values exceeding 35% in a third of studies. Snakes were more frequent nest predators at lower latitudes and less frequent in forested habitat relative to other nest predators. Although 12 species of snakes have been identified as nest predators, ratsnakes Elaphe obsoleta, corn snakes E. guttata and fox snakes E. vulpina were the most frequent, accounting for >70% of all recorded nest predation events by snakes and have been documented preying on nests in 30-65% of studies conducted within their geographic ranges. Endotherm-specialist snakes (Elaphe and Pituophis genera) were more likely to depredate nests in forests and the canopy relative to other snakes, due to their affinity for edge habitat. Predation by only ratsnakes and corn snakes was predominantly nocturnal and only ratsnakes were more likely to prey on nests during the nestling stage. Snakes were not identified to species in over 30% of predation events, underlining the need for more complete reporting of results. A review of research to date suggests the best approach to investigating factors that bring snakes and nests into contact involves combining nesting studies with radio tracking of locally important snake nest predators. C1 [DeGregorio, Brett A.; Chiavacci, Scott J.; Weatherhead, Patrick J.; Benson, Thomas J.; Sperry, Jinelle H.] Univ Illinois, Dept Nat Resources & Environm Sci, Champaign Urbana, IL 61801 USA. [Chiavacci, Scott J.; Benson, Thomas J.] Univ Illinois, Prairie Res Inst, Illinois Nat Hist Survey, Champaign Urbana, IL 61820 USA. [Sperry, Jinelle H.] Engineer Res & Dev Ctr, Champaign, IL 61822 USA. [Willson, John D.] Univ Arkansas, Dept Biol Sci, Fayetteville, AR 72701 USA. RP DeGregorio, BA (reprint author), Univ Illinois, Dept Nat Resources & Environm Sci, Champaign Urbana, IL 61801 USA. EM badegregorio@gmail.com FU Construction Engineering Research Laboratory of the Engineer Research Development Center FX Funding was provided by the Construction Engineering Research Laboratory of the Engineer Research Development Center. We thank Tim Hayden for assistance arranging funding. Phil Vogrinc and Valerie Buxton provided feedback on early drafts. Numerous technicians provided assistance with nest monitoring in Illinois and South Carolina. We wish to thank all the authors who generously shared unreported data with us to facilitate this review. Special thanks to the two reviewers who provided extremely thorough and thoughtful comments, which improved the manuscript significantly. All field work was conducted under South Carolina Dept of Natural Resources permit no. G-11-03 and 23-2012A. Animal procedures conformed to permits approved by the Univ. of Illinois (IACUC no. 11054 and no. 10127) and Univ. of Georgia (AUP no. A2011 04-007-Y2-A0). NR 56 TC 11 Z9 11 U1 7 U2 62 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0908-8857 EI 1600-048X J9 J AVIAN BIOL JI J. Avian Biol. PD JUL PY 2014 VL 45 IS 4 BP 325 EP 333 DI 10.1111/jav.00364 PG 9 WC Ornithology SC Zoology GA AL9TV UT WOS:000339485600003 ER PT J AU Be, NA Allen, JE Brown, TS Gardner, SN McLoughlin, KS Forsberg, JA Kirkup, BC Chromy, BA Luciw, PA Elster, EA Jaing, CJ AF Be, Nicholas A. Allen, Jonathan E. Brown, Trevor S. Gardner, Shea N. McLoughlin, Kevin S. Forsberg, Jonathan A. Kirkup, Benjamin C. Chromy, Brett A. Luciw, Paul A. Elster, Eric A. Jaing, Crystal J. TI Microbial Profiling of Combat Wound Infection through Detection Microarray and Next-Generation Sequencing SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID IRAQI-FREEDOM; ACINETOBACTER; EXPRESSION; MANAGEMENT; INJURIES; COLONIZATION; BIOMARKERS; CYTOKINE; BIOFILM; CARE AB Combat wound healing and resolution are highly affected by the resident microbial flora. We therefore sought to achieve comprehensive detection of microbial populations in wounds using novel genomic technologies and bioinformatics analyses. We employed a microarray capable of detecting all sequenced pathogens for interrogation of 124 wound samples from extremity injuries in combat-injured U. S. service members. A subset of samples was also processed via next-generation sequencing and metagenomic analysis. Array analysis detected microbial targets in 51% of all wound samples, with Acinetobacter baumannii being the most frequently detected species. Multiple Pseudomonas species were also detected in tissue biopsy specimens. Detection of the Acinetobacter plasmid pRAY correlated significantly with wound failure, while detection of enteric-associated bacteria was associated significantly with successful healing. Whole-genome sequencing revealed broad microbial biodiversity between samples. The total wound bioburden did not associate significantly with wound outcome, although temporal shifts were observed over the course of treatment. Given that standard microbiological methods do not detect the full range of microbes in each wound, these data emphasize the importance of supplementation with molecular techniques for thorough characterization of wound-associated microbes. Future application of genomic protocols for assessing microbial content could allow application of specialized care through early and rapid identification and management of critical patterns in wound bioburden. C1 [Be, Nicholas A.; Jaing, Crystal J.] Lawrence Livermore Natl Lab, Phys & Life Sci Directorate, Livermore, CA 94550 USA. [Allen, Jonathan E.; Gardner, Shea N.; McLoughlin, Kevin S.] Lawrence Livermore Natl Lab, Computat Global Secur Directorates, Livermore, CA USA. [Brown, Trevor S.; Forsberg, Jonathan A.; Elster, Eric A.] Naval Med Res Ctr, Regenerat Med Dept, Silver Spring, MD USA. [Brown, Trevor S.; Forsberg, Jonathan A.; Elster, Eric A.] Uniformed Serv Univ Hlth Sci, Surg Crit Care Initiat, Bethesda, MD 20814 USA. [Kirkup, Benjamin C.; Elster, Eric A.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. [Kirkup, Benjamin C.] Walter Reed Army Inst Res, Dept Wound Infect, Silver Spring, MD USA. [Chromy, Brett A.; Luciw, Paul A.] Univ Calif Davis, Sch Med, Dept Pathol & Lab Med, Davis, CA 95616 USA. [Luciw, Paul A.] Univ Calif Davis, Ctr Comparat Med, Davis, CA 95616 USA. RP Be, NA (reprint author), Lawrence Livermore Natl Lab, Phys & Life Sci Directorate, Livermore, CA 94550 USA. EM be1@llnl.gov; jaing2@llnl.gov RI Kirkup, Benjamin/C-3610-2009; Brown, Trevor/F-7392-2015 OI Kirkup, Benjamin/0000-0002-8722-6218; Brown, Trevor/0000-0001-7042-785X FU U.S. Army Medical Research and Materiel Command [MIPR1EO89M1115]; U. S. Navy Bureau of Medicine and Surgery under the Medical Development Program and Office of Naval Research [604771N. 0933.001. A0604]; U. S. Department of Energy by Lawrence Livermore National Laboratory [DE-AC52-07NA27344]; U. S. Government FX This work was sponsored by the U.S. Army Medical Research and Materiel Command (MIPR1EO89M1115). The U. S. Army Medical Research Acquisition Activity (Fort Detrick, MD) is the awarding and administering acquisition office. A portion of this effort was also supported by the U. S. Navy Bureau of Medicine and Surgery under the Medical Development Program and Office of Naval Research work unit (604771N. 0933.001. A0604). This study was performed under the auspices of the U. S. Department of Energy by Lawrence Livermore National Laboratory under contract DE-AC52-07NA27344.; This document was prepared as an account of work sponsored by an agency of the U. S. Government. Neither the U. S. Government nor Lawrence Livermore National Security, LLC, nor any of their employees makes any warranty, expressed or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed or represents that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise does not necessarily constitute or imply its endorsement, recommendation, or favoring by the U. S. Government or Lawrence Livermore National Security, LLC. The views and opinions of authors expressed herein do not necessarily state or reflect those of the U. S. Government or Lawrence Livermore National Security, LLC, and shall not be used for advertising or product endorsement purposes. NR 43 TC 10 Z9 11 U1 4 U2 14 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JUL PY 2014 VL 52 IS 7 BP 2583 EP 2594 DI 10.1128/JCM.00556-14 PG 12 WC Microbiology SC Microbiology GA AL6YM UT WOS:000339279700043 PM 24829242 ER PT J AU Houston, JR Dean, RG AF Houston, J. R. Dean, R. G. TI Shoreline Change on the East Coast of Florida SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE Coastal erosion; coastal accretion; sea level rise ID SEA-LEVEL RISE; SEDIMENT TRANSPORT; BRUUN RULE; SHOREFACE; EVOLUTION; EROSION; USA AB A shoreline change data base for Florida dating back to the mid-1800s is unique in the United States, and perhaps the world, with thousands of shoreline change measurements at a nominal spacing of 300 m. Moreover, data are available on factors contributing to shoreline change, including beach nourishment, disposal of dredged sand outside the littoral zone, cutting of new inlets and subsequent growth of ebb shoals, and longshore sediment transport into and along the east coast of Florida. Effects of relative sea level rise can be estimated using the Bruun Rule. These factors should have caused significant shoreline recession since the mid-1800s, but instead, the east coast of Florida has experienced significant average shoreline advance. The formation of carbonate sand is shown not to account for this difference. Onshore transport of sand from beyond closure depth, probably during episodic storm events, is the only possible source of the large quantity of sand that has advanced on average the shoreline of Florida's east coast. For shorelines with significant offshore deposits of sand, it is possible that sea level rise in conjunction with wave action contributes to onshore transport and shoreline accretion. C1 [Houston, J. R.] US Army, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Dean, R. G.] Univ Florida, Dept Civil & Coastal Engn, Gainesville, FL 32611 USA. RP Houston, JR (reprint author), US Army, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM james.r.houston@usace.army.mil NR 59 TC 10 Z9 10 U1 0 U2 36 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 EI 1551-5036 J9 J COASTAL RES JI J. Coast. Res. PD JUL PY 2014 VL 30 IS 4 BP 647 EP 660 DI 10.2112/JCOASTRES-D-14-00028.1 PG 14 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA AL8CZ UT WOS:000339366800001 ER PT J AU Radomski, MV Brininger, TL AF Radomski, Mary Vining Brininger, Teresa L. TI Occupational Therapy for Servicemember and Veteran Recovery, Resilience, and Reintegration: Opportunities for Societal Contribution and Professional Transformation SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY LA English DT Editorial Material DE combat disorders; military personnel; occupational therapy; veterans ID TRAUMATIC BRAIN-INJURY; POSTTRAUMATIC-STRESS-DISORDER; OPERATION ENDURING FREEDOM; RECONSTRUCTION AIDES; IRAQI FREEDOM; PERFORMANCE; MILITARY C1 [Radomski, Mary Vining] Courage Kenny Res Ctr, Minneapolis, MN 55407 USA. [Brininger, Teresa L.] US Army, War Coll, Carlisle, PA USA. RP Radomski, MV (reprint author), Courage Kenny Res Ctr, 800 East 28th St & Chicago 12212, Minneapolis, MN 55407 USA. EM Mary.Radomski@allina.com; Teresa.Brininger@us.army.mil NR 16 TC 2 Z9 2 U1 1 U2 10 PU AMER OCCUPATIONAL THERAPY ASSOC, INC PI BETHESDA PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA SN 0272-9490 EI 1943-7676 J9 AM J OCCUP THER JI Am. J. Occup. Ther. PD JUL-AUG PY 2014 VL 68 IS 4 BP 379 EP 380 DI 10.5014/ajot.2014.013060 PG 2 WC Rehabilitation SC Rehabilitation GA AL4FR UT WOS:000339088800001 PM 25005499 ER PT J AU Smith, LB Radomski, MV Davidson, LF Finkelstein, M Weightman, MM McCulloch, KL Scherer, MR AF Smith, Laurel B. Radomski, Mary Vining Davidson, Leslie Freeman Finkelstein, Marsha Weightman, Margaret M. McCulloch, Karen L. Scherer, Matthew R. TI Development and Preliminary Reliability of a Multitasking Assessment for Executive Functioning After Concussion SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY LA English DT Article DE brain concussion; executive function; military personnel; reproducibility of results; task performance and analysis ID TRAUMATIC BRAIN-INJURY; ECOLOGICAL VALIDITY; EVERYDAY LIFE; PERFORMANCE; VERSION; PEOPLE; SAMPLE; DAMAGE AB OBJECTIVES. Executive functioning deficits may result from concussion. The Charge of Quarters (CQ) Duty Task is a multitask assessment designed to assess executive functioning in servicemembers after concussion. In this article, we discuss the rationale and process used in the development of the CQ Duty Task and present pilot data from the preliminary evaluation of interrater reliability (IRR). METHOD. Three evaluators observed as 12 healthy participants performed the CQ Duty Task and measured performance using various metrics. Intraclass correlation coefficient (ICC) quantified IRR. RESULTS. The ICC for task completion was .94. ICCs for other assessment metrics were variable. CONCLUSION. Preliminary IRR data for the CQ Duty Task are encouraging, but further investigation is needed to improve IRR in some domains. Lessons learned in the development of the CQ Duty Task could benefit future test development efforts with populations other than the military. C1 [Smith, Laurel B.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. [Radomski, Mary Vining; Finkelstein, Marsha; Weightman, Margaret M.] Courage Kenny Res Ctr, Minneapolis, MN USA. [Davidson, Leslie Freeman] Shenandoah Univ, Winchester, VA USA. [McCulloch, Karen L.] Univ N Carolina, Div Phys Therapy, Chapel Hill, NC USA. [Scherer, Matthew R.] Andrew Rader US Army Hlth Clin, Ft Myer, VA USA. RP Smith, LB (reprint author), US Army, Environm Med Res Inst, 15 Kansas St, Natick, MA 01760 USA. EM laurel.b.smith.mil@mail.mil NR 22 TC 3 Z9 3 U1 1 U2 3 PU AMER OCCUPATIONAL THERAPY ASSOC, INC PI BETHESDA PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA SN 0272-9490 EI 1943-7676 J9 AM J OCCUP THER JI Am. J. Occup. Ther. PD JUL-AUG PY 2014 VL 68 IS 4 BP 439 EP 443 DI 10.5014/ajot.2014.012393 PG 5 WC Rehabilitation SC Rehabilitation GA AL4FR UT WOS:000339088800009 PM 25005507 ER PT J AU Pidcoke, HF Baer, LA Wu, XW Wolf, SE Aden, JK Wade, CE AF Pidcoke, Heather F. Baer, Lisa A. Wu, Xiaowu Wolf, Steven E. Aden, James K. Wade, Charles E. TI Insulin effects on glucose tolerance, hypermetabolic response, and circadian-metabolic protein expression in a rat burn and disuse model SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY LA English DT Article DE insulin; glucose tolerance; hypermetabolism; circadian rhythm; burn and disuse ID CRITICALLY-ILL PATIENTS; ACUTE-PHASE RESPONSE; SKELETAL-MUSCLE; GROWTH-HORMONE; INJURED PATIENTS; THERMAL-INJURY; RECEPTOR SUBSTRATE-1; EXOGENOUS INSULIN; STRESS-RESPONSE; CATABOLISM AB Insulin controls hyperglycemia after severe burns, and its use opposes the hypermetabolic response. The underlying molecular mechanisms are poorly understood, and previous research in this area has been limited because of the inadequacy of animal models to mimic the physiological effects seen in humans with burns. Using a recently published rat model that combines both burn and disuse components, we compare the effects of insulin treatment vs. vehicle on glucose tolerance, hypermetabolic response, muscle loss, and circadian-metabolic protein expression after burns. Male Sprague-Dawley rats were assigned to three groups: cage controls (n = 6); vehicle-treated burn and hindlimb unloading (VBH; n = 11), and insulin-treated burn and hindlimb unloading (IBH; n = 9). With the exception of cage controls, rats underwent a 40% total body surface area burn with hindlimb unloading, then IBH rats received 12 days of subcutaneous insulin injections (5 units.kg(-1) . day(-1)), and VBH rats received an equivalent dose of vehicle. Glucose tolerance testing was performed on day 14, after which blood and tissues were collected for analysis. Body mass loss was attenuated by insulin treatment (VBH = 265 +/- 17 g vs. IBH = 283 +/- 14 g, P = 0.016), and glucose clearance capacity was increased. Soleus and gastrocnemius muscle loss was decreased in the IBH group. Insulin receptor substrate-1, AKT, FOXO-1, caspase-3, and PER1 phosphorylation was altered by injury and disuse, with levels restored by insulin treatment in almost all cases. Insulin treatment after burn and during disuse attenuated the hypermetabolic response, increased glucose clearance, and normalized circadian-metabolic protein expression patterns. Therapies aimed at targeting downstream effectors may provide the beneficial effects of insulin without hypoglycemic risk. C1 [Pidcoke, Heather F.; Wu, Xiaowu; Aden, James K.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Baer, Lisa A.; Wade, Charles E.] Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA. [Wolf, Steven E.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA. RP Wade, CE (reprint author), Univ Texas Hlth Sci Ctr Houston, Ctr Translat Injury Res, 6431 Fannin St,MSB 5-204, Houston, TX 77030 USA. EM Charles.E.Wade@uth.tmc.edu FU NCATS NIH HHS [UL1 TR000371]; NIGMS NIH HHS [1R01GM063120] NR 74 TC 6 Z9 6 U1 0 U2 1 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0363-6119 EI 1522-1490 J9 AM J PHYSIOL-REG I JI Am. J. Physiol.-Regul. Integr. Comp. Physiol. PD JUL 1 PY 2014 VL 307 IS 1 BP R1 EP R10 DI 10.1152/ajpregu.00312.2013 PG 10 WC Physiology SC Physiology GA AL1YG UT WOS:000338921900001 PM 24760998 ER PT J AU Jennissen, CA Harland, KK Wetjen, K Peck, J Hoogerwerf, P Denning, GM AF Jennissen, Charles A. Harland, Karisa K. Wetjen, Kristel Peck, Jeffrey Hoogerwerf, Pam Denning, Gerene M. TI A School-Based Study of Adolescent All-Terrain Vehicle Exposure, Safety Behaviors, and Crash Experience SO ANNALS OF FAMILY MEDICINE LA English DT Article DE all-terrain vehicle; injury prevention; adolescent behavior; rural; safety; helmet; prevention & control; accidents ID INJURY-PREVENTION; UNITED-STATES; ANTICIPATORY GUIDANCE; USE PATTERNS; CHILDREN; YOUTH; ATV; MORTALITY; KNOWLEDGE; DRIVERS AB PURPOSE More youth are killed every year in the United States in all-terrain vehicle (ATV) crashes than on bicycles, and since 2001, one-fifth of all ATV fatalities have involved victims aged 15 years or younger. Effectively preventing pediatric ATV-related deaths and injuries requires knowledge about youth riding practices. Our objective was to examine ATV use, crash prevalence, and riding behaviors among adolescent students in a rural state. METHODS We administered a cross-sectional survey to 4,684 youths aged 11 to 16 years at 30 schools across Iowa from November 2010 to April 2013. Descriptive and comparative analyses were performed. RESULTS Regardless of rurality, at least 75% of students reported having been on an ATV, with 38% of those riding daily or weekly. Among ATV riders, 57% had been in a crash. Most riders engaged in risky behaviors, including riding with passengers (92%), on public roads (81%), or without a helmet (64%). Almost 60% reported engaging in all 3 behaviors; only 2% engaged in none. Multivariable modeling revealed male youth, students riding daily/weekly, and those reporting both riding on public roads and with passengers were 1.61 (95% CI, 1.36-1.91), 3.73 (95% CI, 3.10-4.50), and 3.24 (95% CI, 2.09-5.04) times more likely to report a crash, respectively. CONCLUSIONS Three-fourths of youths surveyed were exposed to ATVs. The majority of riders had engaged in unsafe behaviors and experienced a crash. Given this widespread use and the potentially considerable morbidity of pediatric ATV crashes, prevention efforts, including anticipatory guidance by primary care clinicians serving families at risk, should be a higher priority. C1 [Jennissen, Charles A.; Harland, Karisa K.; Denning, Gerene M.] Univ Iowa, Carver Coll Med, Dept Emergency Med, Iowa City, IA 52242 USA. [Jennissen, Charles A.; Wetjen, Kristel; Hoogerwerf, Pam] Univ Iowa, Childrens Hosp, Iowa City, IA 52242 USA. [Harland, Karisa K.] Univ Iowa Injury Prevent Res, Iowa City, IA USA. [Wetjen, Kristel] Univ Iowa Hosp & Clin, Div Pediat Surg, Iowa City, IA 52242 USA. [Peck, Jeffrey] US Army, Corps Engineers, Washington, DC 20310 USA. RP Jennissen, CA (reprint author), Univ Iowa, Carver Coll Med, Dept Emergency Med, 200 Hawkins Dr, Iowa City, IA 52242 USA. EM charles-jennissen@uiowa.edu FU Kohl's Cares; program of Kohl's FX Support for this study was provided by a grant to the University of Iowa Children's Hospital from Kohl's Cares, a program of Kohl's that supports kids' health and education initiatives nationwide. NR 38 TC 8 Z9 8 U1 0 U2 10 PU ANNALS FAMILY MEDICINE PI LEAWOOD PA 11400 TOMAHAWK CREEK PARKWAY, LEAWOOD, KS 66211-2672 USA SN 1544-1709 EI 1544-1717 J9 ANN FAM MED JI Ann. Fam. Med. PD JUL-AUG PY 2014 VL 12 IS 4 BP 310 EP 316 DI 10.1370/afm.1663 PG 7 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA AL6XF UT WOS:000339276300006 PM 25024238 ER PT J AU Pasiakos, SM Margolis, LM McClung, JP Cao, JJ Whigham, LD Combs, GF Young, AJ AF Pasiakos, S. M. Margolis, L. M. McClung, J. P. Cao, J. J. Whigham, L. D. Combs, G. F. Young, A. J. TI Whole-body protein turnover response to short-term high-protein diets during weight loss: a randomized controlled trial SO INTERNATIONAL JOURNAL OF OBESITY LA English DT Article DE weight loss; protein turnover; net balance; leucine oxidation ID LEUCINE METABOLISM; NITROGEN-BALANCE; ENERGY DEFICIT; EXERCISE; WOMEN; MEN; CARBOHYDRATE; HUMANS; OBESE; MASS AB To determine whole-body protein turnover responses to high-protein diets during weight loss, 39 adults (age, 21+/-1 years; VO2peak, 48+/-1 ml kg(-1) min(-1); body mass index, 25+/-1 kg m(2)) were randomized to diets providing protein at the recommend dietary allowance (RDA), 2 x -RDA or 3 x -RDA. A 10-day weight maintenance period preceded a 21-day, 40% energy deficit. Postabsorptive (FASTED) and postprandial (FED) whole-body protein turnover was determined during weight maintenance (day 10) and energy deficit (day 31) using [1-C-13] leucine. FASTED flux, synthesis and breakdown were lower (P<0.05) for energy deficit than weight maintenance. Protein flux and synthesis were higher (P<0.05) for FED than FASTED. Feeding attenuated (P<0.05) breakdown during weight maintenance but not energy deficit. Oxidation increased (P<0.05) between dietary protein levels and feeding stimulated oxidation, although oxidative responses to feeding were higher (P<0.05) for energy deficit than weight maintenance. FASTED net balance decreased between dietary protein levels, but in the FED state, net balance was lower for 3 x -RDA as compared with RDA and 2 x -RDA (diet-by-state, P<0.05). Consuming dietary protein at levels above the RDA, particularly 3 x -RDA, during short-term weight loss increases protein oxidation with concomitant reductions in net protein balance. C1 [Pasiakos, S. M.; Margolis, L. M.; McClung, J. P.; Young, A. J.] US Army, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Cao, J. J.; Whigham, L. D.; Combs, G. F.] USDA ARS, Grand Forks Human Nutr Res Ctr, Grand Forks, ND 58202 USA. RP Pasiakos, SM (reprint author), US Army, Environm Med Res Inst, Mil Nutr Div, Kansas St,Bldg 42, Natick, MA 01760 USA. EM stefan.pasiakos@us.army.mil RI Pasiakos, Stefan/E-6295-2014; OI Pasiakos, Stefan/0000-0002-5378-5820; , Lee/0000-0002-0652-1304; Whigham, Leah/0000-0002-5376-8967 FU US Army Medical Research and Material Command; US Department of Agriculture, Agricultural Research Service [58-1950-7707] FX This work was supported by the US Army Medical Research and Material Command and the US Department of Agriculture, Agricultural Research Service, under agreement no. 58-1950-7707. NR 34 TC 7 Z9 7 U1 0 U2 12 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0307-0565 EI 1476-5497 J9 INT J OBESITY JI Int. J. Obes. PD JUL PY 2014 VL 38 IS 7 BP 1015 EP 1018 DI 10.1038/ijo.2013.197 PG 4 WC Endocrinology & Metabolism; Nutrition & Dietetics SC Endocrinology & Metabolism; Nutrition & Dietetics GA AL5TU UT WOS:000339197000020 PM 24166063 ER PT J AU Johnson, BD van Helmond, N Curry, TB van Buskirk, CM Convertino, VA Joyner, MJ AF Johnson, Blair D. van Helmond, Noud Curry, Timothy B. van Buskirk, Camille M. Convertino, Victor A. Joyner, Michael J. TI Reductions in central venous pressure by lower body negative pressure or blood loss elicit similar hemodynamic responses SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE hemorrhage; central hypovolemia; heart rate; blood pressure; stroke volume ID ARTERIAL PULSE PRESSURE; CENTRAL HYPOVOLEMIA; STROKE VOLUME; VASOPRESSIN RELEASE; HEMORRHAGIC-SHOCK; TRAUMA DEATHS; HUMANS; TOLERANCE; MODEL; EPIDEMIOLOGY AB The purpose of this study was to compare hemodynamic and blood analyte responses to reduced central venous pressure (CVP) and pulse pressure (PP) elicited during graded lower body negative pressure (LBNP) to those observed during graded blood loss (BL) in conscious humans. We hypothesized that the stimulus-response relationships of CVP and PP to hemodynamic responses during LBNP would mimic those observed during BL. We assessed CVP, PP, heart rate, mean arterial pressure (MAP), and other hemodynamic markers in 12 men during LBNP and BL. Blood samples were obtained for analysis of catecholamines, hematocrit, hemoglobin, arginine vasopressin, and blood gases. LBNP consisted of 5-min stages at 0, 15, 30, and 45 mmHg of suction. BL consisted of 5 min at baseline and following three stages of 333 ml of hemorrhage (1,000 ml total). Individual r(2) values and linear regression slopes were calculated to determine whether the stimulus (CVP and PP)-hemodynamic response trajectories were similar between protocols. The CVP-MAP trajectory was the only CVP-response slope that was statistically different during LBNP compared with BL (0.93 +/- 0.27 vs. 0.13 +/- 0.26; P = 0.037). The PP-heart rate trajectory was the only PP-response slope that was statistically different during LBNP compared with BL (-1.85 +/- 0.45 vs. -0.46 +/- 0.27; P = 0.024). Norepinephrine, hematocrit, and hemoglobin were all lower at termination in the BL protocol compared with LBNP (P < 0.05). Consistent with our hypothesis, LBNP mimics the hemodynamic stimulus-response trajectories observed during BL across a significant range of CVP in humans. C1 [Johnson, Blair D.; van Helmond, Noud; Curry, Timothy B.; Joyner, Michael J.] Mayo Clin, Dept Anesthesiol, Rochester, MN USA. [van Helmond, Noud] Radboud Univ Nijmegen, Med Ctr, Dept Physiol, NL-6525 ED Nijmegen, Netherlands. [van Buskirk, Camille M.] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA. [Convertino, Victor A.] US Army Inst Surg Res, Ft Sam Houston, TX USA. RP Joyner, MJ (reprint author), 200 First St SW, Rochester, MN 55905 USA. EM Joyner.Michael@mayo.edu FU U.S. Army MRMC Combat Casualty Care Research Program [W81XWH-11-1-0823]; American Heart Association Midwest Affiliate Grant [13POST-14380027]; Dutch Heart Foundation [2012SB013] FX Support for this study was provided by U.S. Army MRMC Combat Casualty Care Research Program Grant W81XWH-11-1-0823, American Heart Association Midwest Affiliate Grant 13POST-14380027 to B.D.J., and by Dutch Heart Foundation E. Dekker Stipend 2012SB013 to N.V.H. NR 38 TC 18 Z9 18 U1 0 U2 3 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 EI 1522-1601 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD JUL PY 2014 VL 117 IS 2 BP 131 EP 141 DI 10.1152/japplphysiol.00070.2014 PG 11 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA AL5JM UT WOS:000339169800005 PM 24876357 ER PT J AU Trexler, ST Lundy, JB Chung, KK Nitzschke, SL Burns, CJ Shields, BA Cancio, LC AF Trexler, Scott T. Lundy, Jonathan B. Chung, Kevin K. Nitzschke, Stephanie L. Burns, Christopher J. Shields, Beth A. Cancio, Leopoldo C. TI Prevalence and Impact of Late Defecation in the Critically Ill, Thermally Injured Adult Patient SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID RESTING ENERGY-EXPENDITURE; LATE PARENTERAL-NUTRITION; ENTERAL NUTRITION; CARE PATIENTS; FAILURE; ASPEN AB The aim of this study was to determine the prevalence of late defecation (absence of laxation for more than 6 days after admission) as an indicator of lower-gastrointestinal (GI) tract dysfunction in burn patients. In addition, the authors wanted to determine whether the addition of polyethylene glycol 3350 to the standard bowel regimen led to improvement in markers of lower-GI function and outcomes. The authors conducted a retrospective chart review of patients admitted to the burn intensive care unit during a 26-month period. Inclusion criteria were 20% or more TBSA burn, requirement for mechanical ventilation, and age over 18 years. Of 83 patients included, the prevalence of late defecation was 36.1% (n = 30). There was no association between late defecation and mortality. Patients with late defecation had more frequent episodes of constipation after first defecation (P = .03), of feeding intolerance (P = .007), and received total parenteral nutrition more frequently (P = .005). The addition of polyethylene glycol to the standard bowel regimen did not affect markers of lower-GI function. Late defecation occurs in more than one third of critically ill burn patients. Late defecation was associated with ongoing lower-GI dysfunction, feeding intolerance, and the use of total parenteral nutrition. The causal relationship between these problems has not been determined. A prospective study at the authors' institution is currently planned to attempt to validate late defecation as a marker of lower-GI tract dysfunction, determine its relationship to various outcomes, and determine risk factors for its development. C1 [Trexler, Scott T.] San Antonio Mil Med Ctr, Dept Trauma & Acute Care Surg, Ft Sam Houston, TX USA. [Lundy, Jonathan B.; Chung, Kevin K.; Nitzschke, Stephanie L.; Burns, Christopher J.; Shields, Beth A.; Cancio, Leopoldo C.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Lundy, JB (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. NR 18 TC 6 Z9 6 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X EI 1559-0488 J9 J BURN CARE RES JI J. Burn Care Res. PD JUL-AUG PY 2014 VL 35 IS 4 BP E224 EP E229 DI 10.1097/BCR.0b013e31829b0057 PG 6 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA AL0WM UT WOS:000338847800005 PM 23877139 ER PT J AU Dorsey, KL Bedair, SS Fedder, GK AF Dorsey, K. L. Bedair, S. S. Fedder, G. K. TI Gas chemical sensitivity of a CMOS MEMS cantilever functionalized via evaporation driven assembly SO JOURNAL OF MICROMECHANICS AND MICROENGINEERING LA English DT Article DE resonant chemical sensor; microelectromechanical systems; evaporation driven assembly; gravimetric; CMOS MEMS ID SENSORS AB This work demonstrates an electrostatically actuated resonant microcantilever fabricated in a complementary metal oxide semiconductor process and functionalized with a chemically sorbent polymer layer for the detection of volatile organic compounds. Deposition of the chemically sorbent layer is controlled through evaporation-driven assembly. Analytical and finite element analysis models of the deposited polymer layer on the microcantilever resonant frequency and mass sensitivity are presented. Fabrication of the chemical sensor, including a description of polymer deposition through evaporation-driven assembly within a capillary, is detailed. The completely functionalized resonator demonstrates a limit of detection of 1.6 ppm for toluene. An optimal polymer sensitive layer deposition of 42% of the total beam length is measured from frequency instability and sensitivity tests. C1 [Dorsey, K. L.] Univ Calif Berkeley, Dept Elect Engn & Comp Sci, Berkeley, CA 94720 USA. [Bedair, S. S.] US Army, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD USA. [Fedder, G. K.] Carnegie Mellon Univ, Dept Elect & Comp Engn, Pittsburgh, PA 15213 USA. [Fedder, G. K.] Carnegie Mellon Univ, Inst Complex Engn Syst, Pittsburgh, PA 15213 USA. RP Dorsey, KL (reprint author), Univ Calif Berkeley, Dept Elect Engn & Comp Sci, Berkeley, CA 94720 USA. EM KLDorsey@berkeley.edu NR 20 TC 4 Z9 4 U1 2 U2 26 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0960-1317 EI 1361-6439 J9 J MICROMECH MICROENG JI J. Micromech. Microeng. PD JUL PY 2014 VL 24 IS 7 AR 075001 DI 10.1088/0960-1317/24/7/075001 PG 8 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Instruments & Instrumentation; Physics, Applied SC Engineering; Science & Technology - Other Topics; Instruments & Instrumentation; Physics GA AL1XC UT WOS:000338918600001 ER PT J AU Malachowski, K Jamal, M Jin, QR Polat, B Morris, CJ Gracias, DH AF Malachowski, Kate Jamal, Mustapha Jin, Qianru Polat, Beril Morris, Christopher J. Gracias, David H. TI Self-Folding Single Cell Grippers SO NANO LETTERS LA English DT Article DE Self-assembly; origami; lab-on-a-chip; surgery; nanomedicine; nanomechanics; robotics ID FLOW-CONTROL CONCEPT; SILICON MONOXIDE; THIN-FILMS; HETEROGENEITY; FABRICATION; CULTURE; CANCER; STRESS; MANIPULATION; DYNAMICS AB Given the heterogeneous nature of cultures, tumors, and tissues, the ability to capture, contain, and analyze single cells is important for genomics, proteomics, diagnostics, therapeutics, and surgery. Moreover, for surgical applications in small conduits in the body such as in the cardiovascular system, there is a need for tiny tools that approach the size of the single red blood cells that traverse the blood vessels and capillaries. We describe the fabrication of arrayed or untethered single cell grippers composed of biocompatible and bioresorbable silicon monoxide and silicon dioxide. The energy required to actuate these grippers is derived from the release of residual stress in 3-27 nm thick films, did not require any wires, tethers, or batteries, and resulted in folding angles over 100 degrees with folding radii as small as 765 nm. We developed and applied a finite element model to predict these folding angles. Finally, we demonstrated the capture of live mouse fibroblast cells in an array of grippers and individual red blood cells in untethered grippers which could be released from the substrate to illustrate the potential utility for in vivo operations. C1 [Malachowski, Kate; Jamal, Mustapha; Jin, Qianru; Polat, Beril; Gracias, David H.] Johns Hopkins Univ, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA. [Morris, Christopher J.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Gracias, DH (reprint author), Johns Hopkins Univ, Dept Chem & Biomol Engn, 3400 N Charles St, Baltimore, MD 21218 USA. EM dgracias@jhu.edu OI Gracias, David/0000-0003-2735-4725 FU NIH [1DP2OD004346]; National Science Foundation [CBET-1066898, CMMI-1200241]; Army Research Laboratory; Northrop Grumman FX This research was supported by NIH 1DP2OD004346 and the National Science Foundation grants CBET-1066898 and CMMI-1200241, the Army Research Laboratory, and Northrop Grumman. We thank Professor Benjamin Schaffer for assistance with the modeling software. NR 80 TC 18 Z9 18 U1 8 U2 65 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1530-6984 EI 1530-6992 J9 NANO LETT JI Nano Lett. PD JUL PY 2014 VL 14 IS 7 BP 4164 EP 4170 DI 10.1021/nl500136a PG 7 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA AL2TZ UT WOS:000338979700072 PM 24937214 ER PT J AU Gurton, KP Yuffa, AJ Videen, GW AF Gurton, Kristan P. Yuffa, Alex J. Videen, Gorden W. TI Enhanced facial recognition for thermal imagery using polarimetric imaging SO OPTICS LETTERS LA English DT Article ID SURFACE-ROUGHNESS; POLARIZATION; EMISSION AB We present a series of long-wave-infrared (LWIR) polarimetric-based thermal images of facial profiles in which polarization-state information of the image-forming radiance is retained and displayed. The resultant polarimetric images show enhanced facial features, additional texture, and details that are not present in corresponding conventional thermal imagery. It has been generally thought that conventional thermal imagery (MidIR or LWIR) could not produce the detailed spatial information required for reliable human identification due to the so-called "ghosting" effect often seen in thermal imagery of human subjects. By using polarimetric information, we are able to extract subtle surface features of the human face, thus improving subject identification. Polarimetric image sets considered include the conventional thermal intensity image, S0, the two Stokes images, S1 and S2, and a Stokes image product called the degree-of-linear-polarization image. (C) 2014 Optical Society of America C1 [Gurton, Kristan P.; Yuffa, Alex J.; Videen, Gorden W.] US Army Res Lab, Computat & Informat Sci Directorate Adelphi, Adelphi, MD 20783 USA. RP Gurton, KP (reprint author), US Army Res Lab, Computat & Informat Sci Directorate Adelphi, Adelphi, MD 20783 USA. EM kristan.p.gurton.civ@mail.mil RI Yuffa, Alex/B-5498-2014 OI Yuffa, Alex/0000-0002-3600-1131 FU U.S. Army Research Laboratory (ARL); [W911NF-12-2-0019] FX This research was sponsored by the U.S. Army Research Laboratory (ARL) and was accomplished under Cooperative Agreement Number W911NF-12-2-0019. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the ARL or the U.S. government. The U.S. government is authorized to reproduce and distribute reprints for government purposes, notwithstanding any copyright notation herein. NR 11 TC 12 Z9 13 U1 0 U2 3 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 EI 1539-4794 J9 OPT LETT JI Opt. Lett. PD JUL 1 PY 2014 VL 39 IS 13 BP 3857 EP 3859 DI 10.1364/OL.39.003857 PG 3 WC Optics SC Optics GA AL2CJ UT WOS:000338933200042 PM 24978755 ER PT J AU Xu, XJ Tikuisis, P AF Xu, Xiaojiang Tikuisis, Peter TI Thermoregulatory Modeling for Cold Stress SO COMPREHENSIVE PHYSIOLOGY LA English DT Article ID CONVECTIVE HEAT-TRANSFER; SKIN BLOOD-FLOW; AGED HUMAN SKIN; FEMALE REPRODUCTIVE HORMONES; SURVIVAL-TIME PREDICTION; LOCAL THERMAL CONTROL; X-RAY ABSORPTIOMETRY; HUMAN-BODY; INDUCED VASODILATION; WATER IMMERSION AB Modeling for cold stress has generated a rich history of innovation, has exerted a catalytic influence on cold physiology research, and continues to impact human activity in cold environments. This overview begins with a brief summation of cold thermoregulatory model development followed by key principles that will continue to guide current and future model development. Different representations of the human body are discussed relative to the level of detail and prediction accuracy required. In addition to predictions of shivering and vasomotor responses to cold exposure, algorithms are presented for thermoregulatory mechanisms. Various avenues of heat exchange between the human body and a cold environment are reviewed. Applications of cold thermoregulatory modeling range from investigative interpretation of physiological observations to forecasting skin freezing times and hypothermia survival times. While these advances have been remarkable, the future of cold stress modeling is still faced with significant challenges that are summarized at the end of this overview. Published 2014. C1 [Xu, Xiaojiang] US Army Res Inst Environm Med, Biophys & Biomed Modeling Div, Natick, MA 01760 USA. [Tikuisis, Peter] Def R&D Canada, Sociocognit Syst Sect, Toronto, ON, Canada. RP Xu, XJ (reprint author), US Army Res Inst Environm Med, Biophys & Biomed Modeling Div, Natick, MA 01760 USA. EM xiaojiang.xu.civ@mail.mil NR 241 TC 5 Z9 5 U1 2 U2 26 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 2040-4603 J9 COMPR PHYSIOL JI Compr. Physiol. PD JUL PY 2014 VL 4 IS 3 BP 1057 EP 1081 DI 10.1002/cphy.c130047 PG 25 WC Physiology SC Physiology GA AK9SC UT WOS:000338766000005 PM 24944030 ER PT J AU Arrigo, KR Perovich, DK Pickart, RS Brown, ZW van Dijken, GL Lowry, KE Mills, MM Palmer, MA Balch, WM Bates, NR Benitez-Nelson, CR Brownlee, E Frey, KE Laney, SR Mathis, J Matsuoka, A Mitchell, BG Moore, GWK Reynolds, RA Sosik, HM Swift, JH AF Arrigo, Kevin R. Perovich, Donald K. Pickart, Robert S. Brown, Zachary W. van Dijken, Gert L. Lowry, Kate E. Mills, Matthew M. Palmer, Molly A. Balch, William M. Bates, Nicholas R. Benitez-Nelson, Claudia R. Brownlee, Emily Frey, Karen E. Laney, Samuel R. Mathis, Jeremy Matsuoka, Atsushi Mitchell, B. Greg Moore, G. W. K. Reynolds, Rick A. Sosik, Heidi M. Swift, James H. TI Phytoplankton blooms beneath the sea ice in the Chukchi sea SO DEEP-SEA RESEARCH PART II-TOPICAL STUDIES IN OCEANOGRAPHY LA English DT Article DE Arctic; Sea ice; Phytoplankton ID MARINE MAMMALS; BERING STRAIT; ARCTIC-OCEAN; BARENTS SEA; ALGAL BLOOM; FOOD WEBS; SUMMER; SHELF; FLOW; PHOTOSYNTHESIS AB In the Arctic Ocean, phytoplankton blooms on continental shelves are often limited by light availability, and are therefore thought to be restricted to waters free of sea ice. During July 2011 in the Chukchi Sea, a large phytoplankton bloom was observed beneath fully consolidated pack ice and extended from the ice edge to > 100 km into the pack The bloom was composed primarily of diatoms, with biomass reaching 1291 mg chlorophyll alpha m(-2) and rates of carbon fixation as high as 3.7 g C m(-2) d(-1). Although the sea ice where the bloom was observed was near 100% concentration and 0.8-12 m thick, 30-40% of its surface was covered by melt ponds that transmitted 4-fold more light than adjacent areas of bare ice, providing sufficient light for phytoplankton to bloom. Phytoplankton growth rates associated with the under-ice bloom averaged 0.9 d(-1) and were as high as 1.6 d(-1). We argue that a thinning sea ice cover with more numerous melt ponds over the past decade has enhanced light penetration through the sea ice into the upper water column, favoring the development of these blooms. These observations, coupled with additional biogeochemical evidence, suggest that phytoplankton blooms are currently widespread on nutrient-rich Arctic continental shelves and that satellite-based estimates of annual primary production in waters where under-ice blooms develop are similar to 10-fold too low. These massive phytoplankton blooms represent a marked shift in our understanding of Arctic marine ecosystems. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Arrigo, Kevin R.; Brown, Zachary W.; van Dijken, Gert L.; Lowry, Kate E.; Mills, Matthew M.; Palmer, Molly A.] Stanford Univ, Dept Environm Earth Syst Sci, Stanford, CA 94305 USA. [Perovich, Donald K.] Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. [Perovich, Donald K.] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. [Pickart, Robert S.] Woods Hole Oceanog Inst, Dept Phys Oceanog, Woods Hole, MA 02543 USA. [Balch, William M.] Bigelow Lab Ocean Sci, Harbor, ME 04575 USA. [Bates, Nicholas R.] Bermuda Inst Ocean Sci, St Georges, Bermuda. [Benitez-Nelson, Claudia R.] Univ S Carolina, Marine Sci Program, Columbia, SC 29208 USA. [Benitez-Nelson, Claudia R.] Univ S Carolina, Dept Earth & Ocean Sci, Columbia, SC 29208 USA. [Brownlee, Emily; Laney, Samuel R.; Sosik, Heidi M.] Woods Hole Oceanog Inst, Dept Biol, Woods Hole, MA 02543 USA. [Frey, Karen E.] Clark Univ, Grad Sch Geog, Worcester, MA 01610 USA. [Mathis, Jeremy] NOAA, Pacific Marine Environm Lab, Seattle, WA 98115 USA. [Matsuoka, Atsushi] Univ Paris 06, Lab Oceanog Villefranche, F-06238 Villefranche Sur Mer, France. [Matsuoka, Atsushi] Univ Laval, Dept Biol, Takuvik Joint Int Lab, Quebec City, PQ G1K 7P4, Canada. [Matsuoka, Atsushi] Univ Laval, Quebec Ocean, Quebec City, PQ G1K 7P4, Canada. [Mitchell, B. Greg; Reynolds, Rick A.; Swift, James H.] Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 USA. [Moore, G. W. K.] Univ Toronto, Dept Phys, Toronto, ON M5S 1A7, Canada. RP Arrigo, KR (reprint author), Stanford Univ, Dept Environm Earth Syst Sci, 473 Via Ortega, Stanford, CA 94305 USA. EM arrigo@stanford.edu OI Benitez-Nelson, Claudia/0000-0002-1004-5048; Reynolds, Rick/0000-0002-1579-3600; Lowry, Kate/0000-0002-1604-5428; Sosik, Heidi/0000-0002-4591-2842 FU Ocean Biology and Biogeochemistry Program; Cryosphere Science Program of the National Aeronautic and Space Administration [NNX10AF42G, NNH10A017I, NNX10AT67G, NNX10AG36G, NNX09AE42G, NNX11AF65G, NNX10AH71G, NNX10AGO7G, NNX10AG05G] FX This research was supported by the Ocean Biology and Biogeochemistry Program and the Cryosphere Science Program of the National Aeronautic and Space Administration (NNX10AF42G to K. Arrigo, R. Pickart, and J. Swift, NNH10A017I to D. Perovich, NNX10AT67G to W. Balch, NNX10AG36G to N. Bates and J. Mathis, NNX09AE42G and NNX11AF65G to B. G. Mitchell and C. Benitez-Nelson, NNX10AH71G to K. Frey, NNX10AGO7G to S. Laney and H. Sosik, and NNX10AG05G to R. Reynolds) and by the Malina project. We would like to thank the captain and crew of the USCGC Healy. NR 91 TC 35 Z9 36 U1 11 U2 92 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0967-0645 EI 1879-0100 J9 DEEP-SEA RES PT II JI Deep-Sea Res. Part II-Top. Stud. Oceanogr. PD JUL PY 2014 VL 105 BP 1 EP 16 DI 10.1016/j.dsr2.2014.03.018 PG 16 WC Oceanography SC Oceanography GA AL2TP UT WOS:000338978700001 ER PT J AU Ter-Gabrielyan, N Fromzel, V Yan, Z Han, X Zhang, H Wang, J Dubinskii, M AF Ter-Gabrielyan, N. Fromzel, V. Yan, Z. Han, X. Zhang, H. Wang, J. Dubinskii, M. TI Highly efficient resonantly pumped Er3+:LuVO4 laser SO OPTICAL MATERIALS EXPRESS LA English DT Article ID CONTINUOUS-WAVE; ND-LUVO4 CRYSTAL; PERFORMANCE AB Absorption and emission spectra of Er3+:LuVO4 for the I-4(15/2) <-> I-4(13/2) transitions have been investigated at room and cryogenic temperatures. A corrected energy level diagram was built. An efficient, resonantly pumped Er3+:LuVO4 laser operating at 1609 nm (pi-polarization) or 1597.5 nm (sigma-polarization) was demonstrated. For CW pumping into the 1532 nm absorption line by a narrow-bandwidth Er-fiber laser, the maximum output power was similar to 4.6 W and the maximum slope efficiency was 64% - the best reported efficiency of Er-doped vanadate lasers at room temperature. Resonant pumping into the 1529 nm absorption band with a fiber-coupled diode laser yielded a 62% slope efficiency. To the best of our knowledge, this is the first report on an Er:LuVO4 laser. (C) 2014 Optical Society of America C1 [Ter-Gabrielyan, N.; Fromzel, V.; Dubinskii, M.] US Army Res Lab, Adelphi, MD 20783 USA. [Yan, Z.; Zhang, H.; Wang, J.] Shandong Univ, State Key Lab Crystal Mat, Jinan 250100, Peoples R China. [Han, X.] Lasence Inc, Qingdao 266107, Peoples R China. RP Ter-Gabrielyan, N (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM nikolay.e.ter-gabrielyan.civ@mail.mil NR 10 TC 2 Z9 2 U1 1 U2 13 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 2159-3930 J9 OPT MATER EXPRESS JI Opt. Mater. Express PD JUL 1 PY 2014 VL 4 IS 7 BP 1355 EP 1360 DI 10.1364/OME.4.001355 PG 6 WC Materials Science, Multidisciplinary; Optics SC Materials Science; Optics GA AL1GZ UT WOS:000338875100008 ER PT J AU Watanaveeradej, V Gibbons, RV Simasathien, S Nisalak, A Jarman, RG Kerdpanich, A Tournay, E De La Barrerra, R Dessy, F Toussaint, JF Eckels, KH Thomas, SJ Innis, BL AF Watanaveeradej, Veerachai Gibbons, Robert V. Simasathien, Sriluck Nisalak, Ananda Jarman, Richard G. Kerdpanich, Angkool Tournay, Elodie De La Barrerra, Rafael Dessy, Francis Toussaint, Jean-Francois Eckels, Kenneth H. Thomas, Stephen J. Innis, Bruce L. TI Safety and Immunogenicity of a Rederived, Live-Attenuated Dengue Virus Vaccine in Healthy Adults Living in Thailand: A Randomized Trial SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID PHASE-I TRIAL; INFECTIONS; FORMULATIONS AB Safety and immunogenicity of two formulations of a live-attenuated tetravalent dengue virus (TDEN) vaccine produced using rederived master seeds from a precursor vaccine were tested against a placebo control in a phase II, randomized, double blind trial (NCT00370682). Two doses were administered 6 months apart to 120 healthy, predominantly flavivirus-primed adults (87.5% and 97.5% in the two vaccine groups and 92.5% in the placebo group). Symptoms and signs reported after vaccination were mild to moderate and transient. There were no vaccine-related serious adverse events or dengue cases reported. Asymptomatic, low-level viremia (dengue virus type 2 [DENV-2], DENV-3, or DENV-4) was detected in 5 of 80 vaccine recipients. One placebo recipient developed a subclinical natural DENV-1 infection. All flavivirus-unprimed subjects and at least 97.1% of flavivirus-primed subjects were seropositive to antibodies against all four DENV types 1 and 3 months post-TDEN dose 2. The TDEN vaccine was immunogenic with an acceptable safety profile in flavivirus-primed adults. C1 Phramongkutklao Hosp PMK, Dept Pediat, Bangkok, Thailand. US Army Med Component Armed Forces Res, Inst Med Sci, Bangkok, Thailand. [Thomas, Stephen J.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD 20910 USA. GlaxoSmithKline Vaccines, Wavre, Belgium. Walter Reed Army Inst Res, Translat Med Branch, Bioprod Facil, Silver Spring, MD 20910 USA. GlaxoSmithKline Vaccines, King Of Prussia, PA USA. RP Thomas, SJ (reprint author), Walter Reed Army Inst Res, Viral Dis Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM stephen.j.thomas3.mil@mail.mil FU US Army Medical Research and Materiel Command (Fort Detrick, MD); GlaxoSmithKline Biologicals SA (Rixensart, Belgium) FX This work was funded by US Army Medical Research and Materiel Command (Fort Detrick, MD) and GlaxoSmithKline Biologicals SA (Rixensart, Belgium) under a Cooperative Research and Development Agreement. GlaxoSmithKline Biologicals SA was involved in all stages of study conduct, including analysis of the data, and also took in all costs associated with the development and publication of this manuscript. NR 21 TC 9 Z9 10 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 2014 VL 91 IS 1 BP 119 EP 128 DI 10.4269/ajtmh.13-0452 PG 10 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA AK9MH UT WOS:000338750700022 PM 24865677 ER PT J AU Ringelberg, DB Cole, DM Foley, KL Ruidaz-Santiago, CM Reynolds, CM AF Ringelberg, D. B. Cole, D. M. Foley, K. L. Ruidaz-Santiago, C. M. Reynolds, C. M. TI Compressive strength of soils amended with a bacterial succinoglycan: effects of soluble salts and organic matter SO CANADIAN GEOTECHNICAL JOURNAL LA English DT Article DE biopolymer; mechanical behavior; soil; soluble salts; organic matter ID AGGREGATION; FORCE AB The ability to stabilize soils in a cost effective and efficient manner has utility in both civil and military applications. This study examines the ability of a bacterial succinoglycan to bind and strengthen the silt fractions of three geochemically different surface soils. Small-scale specimen preparation and uniaxial compression test methods were developed to observe effects of biopolymer concentration and silt surface condition on specimen stress-strain response. Results indicate that the biopolymer was effective at strengthening all three natural silts and when applied at concentrations of 1-15 mg.mL(-1), the increase in strength was linear. Silt surface condition was then modified by sequential removal of soluble salts and organic matter. For two of the silts, the removal of salts and organic matter had significant and cumulative negative effects on specimen compressive strength, deformation at peak stress, time to failure, and absorbed strain energy at failure. For a silt characterized by a high cation exchange capacity, high pH, and low aggregate percentage, the removal of organic matter did not reduce compressive strength beyond the level associated with the removal of soluble salts. Results from this study indicate that surface modification can significantly affect the compressive strength of silt materials and identified aggregate content as a principal determinant. C1 [Ringelberg, D. B.; Cole, D. M.; Foley, K. L.; Reynolds, C. M.] US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Ruidaz-Santiago, C. M.] Univ Puerto Rico, Dept Geol, Mayaguez, PR 00708 USA. RP Ringelberg, DB (reprint author), US Army ERDC CRREL, 72 Lyme Rd, Hanover, NH 03755 USA. EM david.b.ringelberg@usace.army.mil NR 22 TC 1 Z9 1 U1 2 U2 11 PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS PI OTTAWA PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA SN 0008-3674 EI 1208-6010 J9 CAN GEOTECH J JI Can. Geotech. J. PD JUL PY 2014 VL 51 IS 7 BP 747 EP 757 DI 10.1139/cgj-2012-0369 PG 11 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA AK8YV UT WOS:000338715600003 ER PT J AU Hoedebecke, K Hertug, M AF Hoedebecke, Kyle Hertug, Marinela TI The Doctor and the Violin SO FAMILY MEDICINE LA English DT Editorial Material C1 [Hoedebecke, Kyle] Womack Army Med Ctr, Family Med Residency Clin, Ft Bragg, NC 28307 USA. [Hertug, Marinela] Ormylia Hlth Ctr, Halkidiki, Greece. RP Hoedebecke, K (reprint author), Womack Army Med Ctr, Family Med Residency Clin, Ft Bragg, NC 28307 USA. EM kyle.l.hoedebecke.mil@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU SOC TEACHERS FAMILY MEDICINE PI LEAWOOD PA 11400 TOMAHAWK CREEK PARKWAY, STE 540, LEAWOOD, KS 66207 USA SN 0742-3225 EI 1938-3800 J9 FAM MED JI Fam. Med. PD JUL-AUG PY 2014 VL 46 IS 7 BP 554 EP 555 PG 2 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA AL0NT UT WOS:000338824300013 PM 25058553 ER PT J AU Harwood, JF Farooq, M Richardson, AG Doud, CW Putnam, JL Szumlas, DE Richardson, JH AF Harwood, James F. Farooq, Muhammad Richardson, Alec G. Doud, Carl W. Putnam, John L. Szumlas, Daniel E. Richardson, Jason H. TI Exploring New Thermal Fog and Ultra-Low Volume Technologies to Improve Indoor Control of the Dengue Vector, Aedes aegypti (Diptera: Culicidae) SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Aedes aegypti; ultra-low volume; thermal fog; indoor space spray; pyriproxyfen ID EMERGENCY CONTROL; ADULTICIDE EFFICACY; PYRIPROXYFEN; FORMULATION; INSECTICIDE; THAILAND; LARVAE AB Control of the mosquito vector, Aedes aegypti (L.), inside human habitations must be performed quickly and efficiently to reduce the risk of transmission during dengue outbreaks. As part of a broad study to assess the efficacy of dengue vector control tools for the U.S. Military, two pesticide delivery systems (ultra-low volume [ULV] and thermal fog) were evaluated for their ability to provide immediate control of Ae. aegypti mosquitoes with a contact insecticide inside simulated urban structures. An insect growth regulator was also applied to determine how well each sprayer delivered lethal doses of active ingredient to indoor water containers for pupal control. Mortality of caged Ae. aegypti, pesticide droplet size, and droplet deposition were recorded after applications. In addition, larval and pupal mortality was measured from treated water samples for 4 wk after the applications. The ULV and the thermal fogger performed equally well in delivering lethal doses of adulticide throughout the structures. The ULV resulted in greater larval mortality and adult emergence inhibition in the water containers for a longer period than the thermal fogger. Therefore, the ULV technology is expected to be a better tool for sustained vector suppression when combined with an effective insect growth regulator. However, during a dengue outbreak, either delivery system should provide an immediate knockdown of vector populations that may lower the risk of infection and allow other suppression strategies to be implemented. C1 [Harwood, James F.; Farooq, Muhammad; Richardson, Alec G.; Doud, Carl W.] Navy Entomol Ctr Excellence, Naval Air Stn, Jacksonville, FL 32212 USA. [Putnam, John L.] US Air Force Acad, HQ USAFA DFB, Dept Biol, Colorado Springs, CO 80840 USA. [Szumlas, Daniel E.] Walter Reed Army Inst Res, Entomol Branch 503, Silver Spring, MD 20910 USA. [Richardson, Jason H.] Armed Forces Pest Management Board, Silver Spring, MD 20910 USA. RP Harwood, JF (reprint author), Navy Entomol Ctr Excellence, Naval Air Stn, Box 43,Bldg 937, Jacksonville, FL 32212 USA. EM james.harwood@med.navy.mil FU Deployed War Fighter Protection Program; Defense Medical Research and Development Program FX We thank J. Kerce, C. Waits, V. Smith, J. Anderson, M. McDonough, J. Wright, M. Denson, R. Platt, L. Santana, J. Francona, and R. Oakes for technical assistance during field and laboratory trials. Also, we thank P. J. Obenauer, P. Nunn, and H. Arimoto for editorial assistance. This research was funded by the Deployed War Fighter Protection Program and the Defense Medical Research and Development Program. NR 29 TC 4 Z9 5 U1 3 U2 13 PU ENTOMOLOGICAL SOC AMER PI ANNAPOLIS PA 3 PARK PLACE, STE 307, ANNAPOLIS, MD 21401-3722 USA SN 0022-2585 EI 1938-2928 J9 J MED ENTOMOL JI J. Med. Entomol. PD JUL PY 2014 VL 51 IS 4 BP 845 EP 854 DI 10.1603/ME14056 PG 10 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA AL0TW UT WOS:000338840700016 PM 25118418 ER PT J AU McKellar, AE Kesler, DC Mitchell, RJ Delaney, DK Walters, JR AF McKellar, Ann E. Kesler, Dylan C. Mitchell, Robert J. Delaney, David K. Walters, Jeffrey R. TI Geographic variation in fitness and foraging habitat quality in an endangered bird SO BIOLOGICAL CONSERVATION LA English DT Article DE Fitness; Fledgling production; Foraging habitat; Group size; Model; Picoides borealis; Red-cockaded woodpecker ID RED-COCKADED WOODPECKERS; POPULATION VIABILITY ANALYSIS; CONSERVATION BIOLOGY; SPATIALLY EXPLICIT; SPOTTED OWL; MANAGEMENT; MODELS; FOREST; NICHE; CLASSIFICATION AB Models are important tools for conservation, but the usefulness of any given model for decision-making depends on its accuracy and precision. Few models designed for conservation purposes are validated with real-world data, and such models are even less likely to be revisited and improved with post-implementation results. We test the performance of a model frequently used and heavily relied-upon for the management of the endangered red-cockaded woodpecker (Picoides borealis). The RCW Foraging Matrix Application incorporates spatially-explicit forest stand data and woodpecker territory locations to produce quantitative assessments of foraging habitat quality. Model parameters were based on expert opinion and research performed on several key populations at a time when range-wide habitat quality was relatively poor. Since the model's inception, many red-cockaded woodpecker populations have been monitored intensely in restored habitat, providing an opportunity to evaluate model performance range-wide. We assessed the relationship of habitat quality, as measured by the RCW Matrix Application, to group size and fledgling production from populations across the species range in the southeastern United States. We also evaluated foraging habitat quality directly by relating woodpecker fitness components to foraging habitat metrics through regression tree analyses. Results showed that some, but not all, of the habitat metrics included in the RCW Matrix Application were consistently related to fitness components range-wide, but threshold values for these habitat metrics identified by regression tree analyses were site-specific rather than universal. Our findings indicate opportunities for improving on "one-size-fits-all" range-wide models with analyses of additional locally-relevant foraging habitat metrics. (C) 2014 Elsevier Ltd. All rights reserved. C1 [McKellar, Ann E.; Kesler, Dylan C.] Univ Missouri, Dept Fisheries & Wildlife Sci, Columbia, MO 65211 USA. [Mitchell, Robert J.] Joseph W Jones Ecol Res Ctr, Newton, GA 39870 USA. [Delaney, David K.] United States Army Engineer Res & Dev Ctr ERDC, Construct Engn Res Lab, Champaign, IL 61822 USA. [Walters, Jeffrey R.] Virginia Tech, Dept Biol Sci, Blacksburg, VA 24061 USA. RP McKellar, AE (reprint author), Environm Canada, 115 Perimeter Rd, Saskatoon, SK S7N 0X4, Canada. EM ann.mckellar@ec.gc.ca FU Department of Defense; Engineer Research and Development Center Construction and Engineering Research Laboratory (ERDC - CERL); University of Missouri FX We thank the many members of the Department of Defense and Department of Agriculture National Forests who shared their data and facilitated data transfer to the University of Missouri, including M. Barron, J. Britcher, L. Carlile, S. Carnahan, J. Drake, R. Fleming, J. Gainey, M. Garner, C. Garrett, N. Hawkins, D. Heins, E. Hoffman, S. Hudson, J. Maitland, S. Marcantel, T. Marston, C. Medler, W. Montague, K. Moore, D. Morrow, S. Pulsifer, T.J. Quarles, K. Rutkofske, and J. Schillaci. T. Hayden, R. Kirgan, W. McDearman, and M. Trager provided valuable discussion and feedback on earlier drafts. We thank J. Carter, P. Doerr, the Sandhills Ecological Institute and the many staff, graduate students and field assistants from Virginia Tech and North Carolina State University who have contributed to collection of demographic data at Fort Bragg. We appreciate the helpful comments on early manuscript drafts provided by F. James and an anonymous reviewer. Funding was provided through a cooperative agreement between the Engineer Research and Development Center Construction and Engineering Research Laboratory (ERDC - CERL) and the University of Missouri. This work was sponsored by the Department of Defense; the content of the information does not necessarily reflect the position or the policy of the government, and no official endorsement should be inferred. NR 43 TC 5 Z9 5 U1 7 U2 46 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0006-3207 EI 1873-2917 J9 BIOL CONSERV JI Biol. Conserv. PD JUL PY 2014 VL 175 BP 52 EP 64 DI 10.1016/j.biocon.2014.04.007 PG 13 WC Biodiversity Conservation; Ecology; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA AK7QS UT WOS:000338623400007 ER PT J AU Morris, MJ Dodson, DW Lucero, PF Haislip, GD Gallup, RA Nicholson, KL Zacher, LL AF Morris, Michael J. Dodson, Darrel W. Lucero, Pedro F. Haislip, Georgette D. Gallup, Roger A. Nicholson, Karin L. Zacher, Lisa L. TI Study of Active Duty Military for Pulmonary Disease Related to Environmental Deployment Exposures (STAMPEDE) SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Article DE military personnel; deployment; asthma; airborne hazards ID KUWAIT OIL FIRES; RESPIRATORY SYMPTOMS; CONSTRICTIVE BRONCHIOLITIS; PARTICULATE MATTER; SOUTHWEST ASIA; LUNG-DISEASE; PERSONNEL; HEALTH; AFGHANISTAN; POPULATION AB Rationale: Because of increased levels of airborne particulate matter in Southwest Asia, deployed military personnel are at risk for developing acute and chronic lung diseases. Increased respiratory symptoms are reported, but limited data exist on reported lung diseases. Objectives: To evaluate new respiratory complaints in military personnel returning from Southwest Asia to determine potential etiologies for symptoms. Methods: Returning military personnel underwent a prospective standardized evaluation for deployment-related respiratory symptoms within 6 months of returning to their duty station. Measurements and Main Results: Prospective standardized evaluation included full pulmonary function testing, high-resolution chest tomography, methacholine challenge testing, and fiberoptic bronchoscopy with bronchoalveolar lavage. Other procedures including lung biopsy were performed if clinically indicated. Fifty patients completed the study procedures. A large percentage (42%) remained undiagnosed, including 12% with normal testing and an isolated increase in lavage neutrophils or lymphocytes. Twenty (40%) patients demonstrated some evidence of airway hyperreactivity to include eight who met asthma criteria and two with findings secondary to gastroesophageal reflux. Four (8%) additional patients had isolated reduced diffusing capacity and the remaining six had other miscellaneous airway disorders. No patients were identified with diffuse parenchymal disease on the basis of computed tomography imaging. A significant number (66%) of this cohort had underlying mental health and sleep disorders. Conclusions: Evaluation of new respiratory symptoms in military personnel after service in Southwest Asia should focus on airway hyperreactivity from exposures to higher levels of ambient particulate matter. These patients may be difficult to diagnose and require close follow-up. C1 [Morris, Michael J.; Lucero, Pedro F.; Haislip, Georgette D.] San Antonio Mil Med Ctr, Dept Med, Pulm Crit Care Serv, Ft Sam Houston, TX 78234 USA. [Dodson, Darrel W.] William Beaumont Army Med Ctr, Dept Med, Pulm Crit Care Serv, Ft Bliss, TX USA. [Gallup, Roger A.; Nicholson, Karin L.] Carl R Darnall Army Med Ctr, Dept Med, Pulm Crit Care Serv, Ft Hood, TX USA. [Zacher, Lisa L.] Orlando Vet Affairs Med Ctr, Orlando, FL USA. RP Morris, MJ (reprint author), San Antonio Mil Med Ctr, Pulm Dis Serv MCHE MDP, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM michael.j.morris34.civ@mail.mil NR 38 TC 15 Z9 15 U1 1 U2 7 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PD JUL 1 PY 2014 VL 190 IS 1 BP 77 EP 84 DI 10.1164/rccm.201402-0372OC PG 8 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA AK3KX UT WOS:000338323900015 PM 24922562 ER PT J AU Klinger, D Wang, CX Connal, LA Audus, DJ Jang, SG Kraemer, S Killops, KL Fredrickson, GH Kramer, EJ Hawker, CJ AF Klinger, Daniel Wang, Cynthia X. Connal, Luke A. Audus, Debra J. Jang, Se Gyu Kraemer, Stephan Killops, Kato L. Fredrickson, Glenn H. Kramer, Edward J. Hawker, Craig J. TI A Facile Synthesis of Dynamic, Shape-Changing Polymer Particles SO ANGEWANDTE CHEMIE-INTERNATIONAL EDITION LA English DT Article DE block copolymers; microgels; nanoparticles; shape anisotropy; stimuli-responsive materials ID BLOCK-COPOLYMER NANOPARTICLES; SEPARATED STRUCTURES; GOLD NANOPARTICLES; PHASE-SEPARATION; THIN-FILMS; BEHAVIOR; SOLVENT; DEFORMATION; AGGREGATION; ORIENTATION AB We herein report a new facile strategy to ellipsoidal block copolymer nanoparticles that exhibit a pH-triggered anistropic swelling profile. In a first step, elongated particles with an axially stacked lamellae structure are selectively prepared by utilizing functional surfactants to control the phase separation of symmetric polystyrene-b-poly(2-vinylpyridine) (PS-b-P2VP) in dispersed droplets. In a second step, the dynamic shape change is realized by cross-linking the P2VP domains, thereby connecting glassy PS discs with pH-sensitive hydrogel actuators. C1 [Klinger, Daniel; Wang, Cynthia X.; Audus, Debra J.; Jang, Se Gyu; Kraemer, Stephan; Fredrickson, Glenn H.; Kramer, Edward J.; Hawker, Craig J.] Univ Calif Santa Barbara, Mat Res Lab, Santa Barbara, CA 93106 USA. [Connal, Luke A.] Univ Melbourne, Dept Chem & Biomol Engn, Melbourne, Vic 3010, Australia. [Killops, Kato L.] US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Hawker, CJ (reprint author), Univ Calif Santa Barbara, Mat Res Lab, Santa Barbara, CA 93106 USA. EM hawker@mrl.ucsb.edu RI Kraemer, Stephan/I-3186-2014; OI Kraemer, Stephan/0000-0003-0577-7444; Luke, Connal/0000-0001-7519-977X FU MRSEC Program of the National Science Foundation (NSF) [DMR-1121053]; Institute for Collaborative Biotechnologies through U.S. Army Research Office [W911NF-09-0001]; National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services [HHSN268201000046C] FX This work was supported by the MRSEC Program of the National Science Foundation (NSF) under Award DMR-1121053 (L. A. C., D.J.A., S. K., E.J.K., and C.J.H.), the Institute for Collaborative Biotechnologies through grant W911NF-09-0001 from the U.S. Army Research Office (D. K., S.G.J., K. L. K., G. H. F., and C.J.H.), and the National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, under Contract No. HHSN268201000046C (D. K., C. W., and C.J.H.). Facilities support from the CNSI-MRL Center for Scientific Computing (DMR-1121053 and CNS-0960316) is acknowledged. The content of the information does not necessarily reflect the position or the policy of the US government and no official endorsement should be inferred. NR 49 TC 45 Z9 45 U1 25 U2 208 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 1433-7851 EI 1521-3773 J9 ANGEW CHEM INT EDIT JI Angew. Chem.-Int. Edit. PD JUL PY 2014 VL 53 IS 27 BP 7018 EP 7022 DI 10.1002/anie.201400183 PG 5 WC Chemistry, Multidisciplinary SC Chemistry GA AJ9IR UT WOS:000338023000035 PM 24700705 ER PT J AU Johnson, JC Martinez, O Honko, AN Hensley, LE Olinger, GG Basler, CF AF Johnson, Joshua C. Martinez, Osvaldo Honko, Anna N. Hensley, Lisa E. Olinger, Gene G. Basler, Christopher F. TI Pyridinyl imidazole inhibitors of p38 MAP kinase impair viral entry and reduce cytokine induction by Zaire ebolavirus in human dendritic cells SO ANTIVIRAL RESEARCH LA English DT Article DE Ebola virus; p38 MAPK; Dendritic cell; THP-1; Entry; Antigen-presenting cell ID ACTIVATED PROTEIN-KINASE; NF-KAPPA-B; VIRUS-INFECTION; HEMORRHAGIC-FEVER; MONOCYTE DIFFERENTIATION; SIGNALING PATHWAY; REPLICATION; PATHOGENESIS; MATURATION; TARGETS AB Antigen presenting cells (APCs), including macrophages and dendritic cells, are early and sustained targets of Ebola virus (EBOV) infection in vivo. Because EBOV activates mitogen-activated protein kinase (MAPK) signaling upon infection of APCs, we evaluated the effect of pyridinyl imidazole inhibitors of p38 MAPK on EBOV infection of human APCs and EBOV mediated cytokine production from human DCs. The p38 MAPK inhibitors reduced viral replication in PMA-differentiated macrophage-like human THP-1 cells with an IC50 of 4.73 mu M (SB202190), 8.26 mu M (p38kinhIII) and 8.21 mu M (SB203580) and primary human monocyte-derived dendritic cells (MDDCs) with an IC50 of 2.67 mu M (SB202190). Furthermore, cytokine production from EBOV-treated MDDCs was inhibited in a dose-dependent manner. A control pyridinyl imidazole compound failed to inhibit either EBOV infection or cytokine induction. Using an established EBOV virus-like particle (VLP) entry assay, we demonstrate that inhibitor pretreatment blocked VLP entry suggesting that the inhibitors blocked infection and replication at least in part by blocking EBOV entry. Taken together, our results indicate that pyridinyl imidazole p38 MAPK inhibitors may serve as leads for the development of therapeutics to treat EBOV infection. (C) 2014 Elsevier B.V. All rights reserved. C1 [Johnson, Joshua C.; Honko, Anna N.; Hensley, Lisa E.; Olinger, Gene G.] US Army Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Martinez, Osvaldo; Basler, Christopher F.] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA. RP Basler, CF (reprint author), Icahn Sch Med Mt Sinai, Dept Microbiol, Box 1124,1 Gustave L Levy Pl, New York, NY 10029 USA. EM chris.basler@mssm.edu OI Johnson, Joshua/0000-0002-5677-3841; Honko, Anna/0000-0001-9165-148X FU NIH [AI097568, AI109664, AI057158] FX This work was supported by NIH grants AI097568, AI109664 and AI057158 (Northeast Biodefense Center-Lipkin) to C.F.B. We thank Dr. Victor E. Marquez (National Cancer Institute) for providing DZNep. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. NR 57 TC 11 Z9 12 U1 0 U2 42 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 EI 1872-9096 J9 ANTIVIR RES JI Antiviral Res. PD JUL PY 2014 VL 107 BP 102 EP 109 DI 10.1016/j.antiviral.2014.04.014 PG 8 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA AK4RT UT WOS:000338412500014 PM 24815087 ER PT J AU Schoepp, RJ Rossi, CA Khan, SH Goba, A Fair, JN AF Schoepp, Randal J. Rossi, Cynthia A. Khan, Sheik H. Goba, Augustine Fair, Joseph N. TI Undiagnosed Acute Viral Febrile Illnesses, Sierra Leone SO EMERGING INFECTIOUS DISEASES LA English DT Article ID RIFT-VALLEY-FEVER; LASSA HEMORRHAGIC-FEVER; OUTCOME CASE-REPORT; WEST-AFRICA; VIRUS; ANTIBODIES; CONGO; REEMERGENCE; INFECTIONS; MAURITANIA AB Sierra Leone in West Africa is in a Lassa fever hyperendemic region that also includes Guinea and Liberia. Each year, suspected Lassa fever cases result in submission of approximate to 500-700 samples to the Kenema Government Hospital Lassa Diagnostic Laboratory in eastern Sierra Leone. Generally only 30%-40% of samples tested are positive for Lassa virus (LASV) antigen and/or LASV-specific IgM; thus, 60%-70% of these patients have acute diseases of unknown origin. To investigate what other arthropod-borne and hemorrhagic fever viral diseases might cause serious illness in this region and mimic Lassa fever, we tested patient serum samples that were negative for malaria parasites and LASV. Using IgM-capture ELISAs, we evaluated samples for antibodies to arthropod-borne and other hemorrhagic fever viruses. Approximately 25% of LASV-negative patients had IgM to dengue, West Nile, yellow fever, Rift Valley fever, chikungunya, Ebola, and Marburg viruses but not to Crimean-Congo hemorrhagic fever virus. C1 [Schoepp, Randal J.; Rossi, Cynthia A.] US Army Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Khan, Sheik H.; Goba, Augustine] Kenema Govt Hosp, Kenema, Sierra Leone. [Fair, Joseph N.] Metabiota, San Francisco, CA USA. RP Schoepp, RJ (reprint author), US Army Med Res Inst Infect Dis, Diagnost Syst Div, 1425 Porter St, Ft Detrick, MD 21702 USA. EM randal.j.schoepp.civ@mail.mil FU Division of Global Emerging Infections Surveillance and Response System Operations at the Armed Forces Health Surveillance Center through USAMRIID [C0169_10_RD, C0410_11_RD, C0602_12_RD]; US Department of Defense Cooperative Biological Engagement Program through Metabiota, Inc., San Francisco, CA, USA FX The laboratory work was funded in part by the Division of Global Emerging Infections Surveillance and Response System Operations at the Armed Forces Health Surveillance Center, Research Plans (C0169_10_RD, C0410_11_RD, and C0602_12_RD), through USAMRIID and by the US Department of Defense Cooperative Biological Engagement Program, through Metabiota, Inc., San Francisco, CA, USA. NR 39 TC 48 Z9 50 U1 0 U2 55 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JUL PY 2014 VL 20 IS 7 BP 1176 EP 1182 DI 10.3201/eid2007.131265 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AK4JB UT WOS:000338389900011 PM 24959946 ER PT J AU Smith, R Stain, SC McFadden, DW Finlayson, SRG Jones, DB Reid-Lombardo, K AF Smith, Richard Stain, Steven C. McFadden, David W. Finlayson, Samuel R. G. Jones, Daniel B. Reid-Lombardo, KMarie CA SSAT TI Will There Be a Good General Surgeon When You Need One? (Part II) Solutions and Taking Back General Surgery SO JOURNAL OF GASTROINTESTINAL SURGERY LA English DT Article; Proceedings Paper CT 54th Annual Meeting of the Society-for-Surgery-of-the-Alimentary-Tract (SSAT) / Digestive Disease Week (DDW) CY MAY 17-21, 2013 CL Orlando, FL SP Soc Surg Alimentary Tract DE Surgeon Shortage; Health care policy; Affordable health care act; Advocacy; Workforce; SSAT ID REGIONAL-VARIATIONS; UNITED-STATES; CARE; WORKFORCE; RESIDENTS; QUALITY AB Multiple reports have cited the looming shortage of physicians over the next decades related to increasing demand, an aging of the population, and a stagnant level in the production of new physicians. General surgery shares in this problem, and the specialty is "stressed" by a declining workforce related to increasing specialization that leaves gaps in emergency, trauma, and rural surgical care. The Society of Surgery of the Alimentary Tract (SSAT) Public Policy and Advocacy Committee sponsored panel discussions regarding the general surgery workforce shortage at the Digestive Disease Week 2012 and 2013 meetings. The 2012 panel focused on defining the problem. This is the summation of the series with the solutions to the general surgery workforce shortage as offered by the 2013 panel. C1 [Smith, Richard] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Stain, Steven C.] Albany Med Coll, Dept Surg, Albany, NY 12208 USA. [McFadden, David W.] Univ Connecticut, Dept Surg, Farmington, CT USA. [Finlayson, Samuel R. G.; Jones, Daniel B.] Beth Israel Deaconess Med Ctr, Dept Surg, Boston, MA 02215 USA. [SSAT] Soc Surg Alimentary Tract, Beverly, MA USA. [Reid-Lombardo, KMarie] Mayo Clin, Dept Surg, Rochester, MN 55905 USA. RP Reid-Lombardo, K (reprint author), Mayo Clin, Dept Surg, 200 First St SW, Rochester, MN 55905 USA. EM Reidlombardo.kaye@mayo.edu FU NHLBI NIH HHS [R01 HL119248]; NIBIB NIH HHS [R01 EB010037, R01 EB014305, R01 EB005807, R01 EB009362] NR 34 TC 3 Z9 3 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1091-255X EI 1873-4626 J9 J GASTROINTEST SURG JI J. Gastrointest. Surg. PD JUL PY 2014 VL 18 IS 7 BP 1334 EP 1342 DI 10.1007/s11605-014-2522-4 PG 9 WC Gastroenterology & Hepatology; Surgery SC Gastroenterology & Hepatology; Surgery GA AK0QD UT WOS:000338118600018 PM 24748342 ER PT J AU Rives, T AF Rives, Tim TI Like Footprints in the Sand: Searching for Eisenhower's Climactic D-Day Words SO JOURNAL OF MILITARY HISTORY LA English DT Article AB Given the importance of General Dwight D. Eisenhower's decision to launch the invasion of Normandy on 6 June 1944, both to the outcome of the war and to him personally, it is mysterious that neither he nor the commanders who witnessed his supreme moment could agree on what he said when he set the Allied force in motion. While the fog of war explains some of the discrepancies in the eyewitness accounts, Eisenhower's modest character also plays a role in the mystery. Seventy years later, we still do not know what words unleashed the Allied assault on the Atlantic Wall. C1 [Rives, Tim] Eisenhower Presidential Lib Museum & Boyhood Home, Abilene, KS 67410 USA. [Rives, Tim] Natl Archives, Kansas City, MO USA. [Rives, Tim] US Army, Washington, DC USA. RP Rives, T (reprint author), Eisenhower Presidential Lib Museum & Boyhood Home, Abilene, KS 67410 USA. NR 42 TC 0 Z9 0 U1 0 U2 2 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2014 VL 78 IS 3 BP 1057 EP 1067 PG 11 WC History SC History GA AK4IC UT WOS:000338386900006 ER PT J AU House, JM AF House, Jonathan M. TI Three German Invasions of France: The Summer Campaigns of 1870-1914-1940. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [House, Jonathan M.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. RP House, JM (reprint author), US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 1 U2 2 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2014 VL 78 IS 3 BP 1135 EP 1136 PG 2 WC History SC History GA AK4IC UT WOS:000338386900037 ER PT J AU Hull, MM AF Hull, Mark M. TI Ireland during the Second World War: Farewell to Plato's Cave SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Hull, Mark M.] US Army, Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. RP Hull, MM (reprint author), US Army, Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2014 VL 78 IS 3 BP 1164 EP 1165 PG 2 WC History SC History GA AK4IC UT WOS:000338386900056 ER PT J AU Shepard, NP Westrick, RB Johnson, MR AF Shepard, Nathan P. Westrick, Richard B. Johnson, Michael R. TI MUSCULOSKELETAL IMAGING SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Editorial Material C1 [Shepard, Nathan P.; Westrick, Richard B.; Johnson, Michael R.] Baylor Univ Sports Phys Therapy Doctoral Residenc, US Army, Keller Army Community Hosp, West Point, NY 10996 USA. RP Shepard, NP (reprint author), Baylor Univ Sports Phys Therapy Doctoral Residenc, US Army, Keller Army Community Hosp, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD JUL PY 2014 VL 44 IS 7 BP 541 EP 541 DI 10.2519/jospt.2014.0408 PG 1 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA AK4KU UT WOS:000338394400010 PM 24981223 ER PT J AU Pollara, J Bonsignori, M Moody, MA Liu, PH Alam, SM Hwang, KK Gurley, TC Kozink, DM Armand, LC Marshall, DJ Whitesides, JF Kaewkungwal, J Nitayaphan, S Pitisuttithum, P Rerks-Ngarm, S Robb, ML O'Connell, RJ Kim, JH Michael, NL Montefiori, DC Tomaras, GD Liao, HX Haynes, BF Ferrari, G AF Pollara, Justin Bonsignori, Mattia Moody, M. Anthony Liu, Pinghuang Alam, S. Munir Hwang, Kwan-Ki Gurley, Thaddeus C. Kozink, Daniel M. Armand, Lawrence C. Marshall, Dawn J. Whitesides, John F. Kaewkungwal, Jaranit Nitayaphan, Sorachai Pitisuttithum, Punnee Rerks-Ngarm, Supachai Robb, Merlin L. O'Connell, Robert J. Kim, Jerome H. Michael, Nelson L. Montefiori, David C. Tomaras, Georgia D. Liao, Hua-Xin Haynes, Barton F. Ferrari, Guido TI HIV-1 Vaccine-Induced C1 and V2 Env-Specific Antibodies Synergize for Increased Antiviral Activities SO JOURNAL OF VIROLOGY LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; HUMAN MONOCLONAL-ANTIBODIES; DEPENDENT CELLULAR CYTOTOXICITY; BROADLY NEUTRALIZING ANTIBODIES; CD4-BINDING SITE; VIRION CAPTURE; EFFICACY TRIAL; IGG BINDING; SUBTYPE-B; V3 LOOP AB The RV144 ALVAC/AIDSVax HIV-1 vaccine clinical trial showed an estimated vaccine efficacy of 31.2%. Viral genetic analysis identified a vaccine-induced site of immune pressure in the HIV-1 envelope (Env) variable region 2 (V2) focused on residue 169, which is included in the epitope recognized by vaccinee-derived V2 monoclonal antibodies. The ALVAC/AIDSVax vaccine induced antibody-dependent cellular cytotoxicity (ADCC) against the Env V2 and constant 1 (C1) regions. In the presence of low IgA Env antibody levels, plasma levels of ADCC activity correlated with lower risk of infection. In this study, we demonstrate that C1 and V2 monoclonal antibodies isolated from RV144 vaccinees synergized for neutralization, infectious virus capture, and ADCC. Importantly, synergy increased the HIV-1 ADCC activity of V2 monoclonal antibody CH58 at concentrations similar to that observed in plasma of RV144 vaccinees. These findings raise the hypothesis that synergy among vaccine-induced antibodies with different epitope specificities contributes to HIV-1 antiviral antibody responses and is important to induce for reduction in the risk of HIV-1 transmission. IMPORTANCE The Thai RV144 ALVAC/AIDSVax prime-boost vaccine efficacy trial represents the only example of HIV-1 vaccine efficacy in humans to date. Studies aimed at identifying immune correlates involved in the modest vaccine-mediated protection identified HIV-1 envelope (Env) variable region 2-binding antibodies as inversely correlated with infection risk, and genetic analysis identified a site of immune pressure within the region recognized by these antibodies. Despite this evidence, the antiviral mechanisms by which variable region 2-specific antibodies may have contributed to lower rates of infection remain unclear. In this study, we demonstrate that vaccine-induced HIV-1 envelope variable region 2 and constant region 1 antibodies synergize for recognition of virus-infected cells, infectious virion capture, virus neutralization, and antibody-dependent cellular cytotoxicity. This is a major step in understanding how these types of antibodies may have cooperatively contributed to reducing infection risk and should be considered in the context of prospective vaccine design. C1 [Pollara, Justin; Bonsignori, Mattia; Moody, M. Anthony; Liu, Pinghuang; Alam, S. Munir; Hwang, Kwan-Ki; Gurley, Thaddeus C.; Kozink, Daniel M.; Armand, Lawrence C.; Marshall, Dawn J.; Whitesides, John F.; Montefiori, David C.; Tomaras, Georgia D.; Liao, Hua-Xin; Haynes, Barton F.; Ferrari, Guido] Duke Univ, Med Ctr, Duke Human Vaccine Inst, Durham, NC 27708 USA. [Pollara, Justin; Montefiori, David C.; Tomaras, Georgia D.; Ferrari, Guido] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA. [Bonsignori, Mattia; Alam, S. Munir; Whitesides, John F.; Liao, Hua-Xin; Haynes, Barton F.] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA. [Moody, M. Anthony] Duke Univ, Med Ctr, Dept Infect Dis, Durham, NC USA. [Moody, M. Anthony] Duke Univ, Med Ctr, Dept Pediat, Durham, NC 27710 USA. [Alam, S. Munir] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA. [Tomaras, Georgia D.; Haynes, Barton F.] Duke Univ, Med Ctr, Dept Immunol, Durham, NC USA. [Tomaras, Georgia D.] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC USA. [Kaewkungwal, Jaranit] Mahidol Univ, Fac Trop Med, Ctr Excellence Biomed & Publ Hlth Informat BIOPHI, Bangkok, Thailand. [Nitayaphan, Sorachai; O'Connell, Robert J.] AFRIMS, Dept Retrovirol, US Army Med Component, Bangkok, Thailand. [Pitisuttithum, Punnee] Mahidol Univ, Bangkok 10700, Thailand. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand. [Robb, Merlin L.; Kim, Jerome H.; Michael, Nelson L.] US Mil HIV Res Program, Bethesda, MD USA. RP Ferrari, G (reprint author), Duke Univ, Med Ctr, Duke Human Vaccine Inst, Durham, NC 27708 USA. EM gflmp@duke.edu RI Ferrari, Guido/A-6088-2015; Tomaras, Georgia/J-5041-2016 FU Center for HIV/AIDS Vaccine Immunology-Immunogen Discovery (CHAVI-ID); CHAVI [UM-AI100645, U01 AI067854]; National Institutes of Health (NIH/NIAID/DAIDS); Bill and Melinda Gates Foundation's Collaboration for AIDS Vaccine Discovery [1033098, 1040758, 1032144, 1032325, 64518]; U. S. Army Medical Research and Material Command (USAMRMC) [Y1-AI-2642-12]; National Institutes of Allergy and Infectious Diseases [W81XWH-07-2-0067]; Foundation for the Advancement of Military Medicine, Inc.; U. S. Department of Defense (DOD); NIH; NIAID [AI07392] FX This work was supported by the Center for HIV/AIDS Vaccine Immunology-Immunogen Discovery (CHAVI-ID) and CHAVI (UM-AI100645 and U01 AI067854), National Institutes of Health (NIH/NIAID/DAIDS), Bill and Melinda Gates Foundation's Collaboration for AIDS Vaccine Discovery Grants (Haynes B Cell Lineage [1033098] and Haynes IgA [1040758], Montefiori CA-VIMC [1032144], Koup CT-VIMC [1032325]), 64518). In addition, funding was provided by Interagency Agreement Y1-AI-2642-12 between U. S. Army Medical Research and Material Command (USAMRMC) and the National Institutes of Allergy and Infectious Diseases through a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U. S. Department of Defense (DOD). J. P. was supported by NIH, NIAID grant AI07392. NR 38 TC 47 Z9 47 U1 1 U2 13 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X EI 1098-5514 J9 J VIROL JI J. Virol. PD JUL PY 2014 VL 88 IS 14 BP 7715 EP 7726 DI 10.1128/JVI.00156-14 PG 12 WC Virology SC Virology GA AK5CT UT WOS:000338442600005 PM 24807721 ER PT J AU Smith, R AF Smith, Roger TI Innovate Like It's 1985 SO RESEARCH-TECHNOLOGY MANAGEMENT LA English DT Editorial Material C1 [Smith, Roger] Florida Hosp, Nicholson Ctr Surg Adv, Orlando, FL 32803 USA. [Smith, Roger] US Army Simulat, Orlando, FL USA. [Smith, Roger] Titan Corp, San Diego, CA USA. [Smith, Roger] BTG Inc, Technol, Jacksonville, FL USA. RP Smith, R (reprint author), Florida Hosp, Nicholson Ctr Surg Adv, Orlando, FL 32803 USA. EM roger.smith@flhosp.org NR 0 TC 0 Z9 0 U1 0 U2 1 PU INDUSTRIAL RESEARCH INST, INC PI ARLINGTON PA 2300 CLARENDON BLVD, STE 400, ARLINGTON, VA 22201 USA SN 0895-6308 EI 1930-0166 J9 RES TECHNOL MANAGE JI Res.-Technol. Manage. PD JUL-AUG PY 2014 VL 57 IS 4 BP 53 EP 55 DI 10.5437/08956308X5704007 PG 3 WC Business; Engineering, Industrial; Management SC Business & Economics; Engineering GA AK0IB UT WOS:000338095000012 ER PT J AU Rajagopalan, M Bhatia, MA Tschopp, MA Srolovitz, DJ Solanki, KN AF Rajagopalan, M. Bhatia, M. A. Tschopp, M. A. Srolovitz, D. J. Solanki, K. N. TI Atomic-scale analysis of liquid-gallium embrittlement of aluminum grain boundaries SO ACTA MATERIALIA LA English DT Article DE Liquid metal embrittlement; Atomistic simulation; Grain boundary; Segregation ID 5 MACROSCOPIC PARAMETERS; SYMMETRICAL TILT BOUNDARIES; TOTAL-ENERGY CALCULATIONS; AUGMENTED-WAVE METHOD; METAL EMBRITTLEMENT; CHARACTER-DISTRIBUTION; SOLUTE SEGREGATION; MOLECULAR-DYNAMICS; CUBIC METALS; FCC METALS AB Material strengthening and embrittlement are controlled by intrinsic interactions between defects, such as grain boundaries (GBs), and impurity atoms that alter the observed deformation and failure mechanisms in metals. In this work, we explore the role of atomistic-scale energetics on liquid-metal embrittlement of aluminum (Al) due to gallium (Ga). Ab initio and molecular mechanics were employed to probe the formation/binding energies of vacancies and segregation energies of Ga for < 1 0 0 >, < 1 1 0 > and < 1 1 1 > symmetric tilt grain boundaries (STGBs) in Al. We found that the GB local arrangements and resulting structural units have a significant influence on the magnitude of the vacancy binding energies. For example, the mean vacancy binding energies for < 1 0 0 >, < 1 1 0 > and < 1 1 1 > STGBs in the 1st layer was found to be -0.63, -0.26 and -0.60 eV, respectively. However, some GBs exhibited vacancy binding energies closer to bulk values, indicating interfaces with zero sink strength, i.e. these GBs may not provide effective pathways for vacancy diffusion. The results from the present work showed that the GB structure and the associated free volume also play significant roles in Ga segregation and the subsequent embrittlement of Al. The Ga mean segregation energies for < 1 0 0 >, < 1 1 0 > and < 1 1 1 > STGBs in the 1st layer were found to be -0.21, -0.09 and -0.21 eV, respectively, suggesting a stronger correlation between the GB structural unit, its free volume and the segregation behavior. Furthermore, as the GB free volume increased, the difference in segregation energies between the 1st layer and the 0th layer increased. Thus, the GB character and free volume provide an important key to understanding the degree of anisotropy in various systems. The overall characteristic Ga absorption length scale was found to be about similar to 10, 8 and 12 layers for < 1 0 0 >, < 1 1 0 > and < 1 1 1 > STGBs, respectively. In addition, a few GBs of different tilt axes with relatively high segregation energies (between 0 and -0.1 eV) at the boundary were also found. This finding provides a new atomistic perspective for the GB engineering of materials with smart GB networks to mitigate or control liquid-metal embrittlement and more general embrittlement phenomena in alloys. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Rajagopalan, M.; Bhatia, M. A.; Solanki, K. N.] Arizona State Univ, Sch Engn Matter Transport & Energy, Tempe, AZ 85281 USA. [Tschopp, M. A.] US Army, Ballist Res Lab, Dynam Res Corp, High Peiformance Technol Grp, Aberdeen Proving Ground, MD 21005 USA. [Srolovitz, D. J.] Univ Penn, Dept Mat Sci & Engn, Philadelphia, PA 19104 USA. [Srolovitz, D. J.] Univ Penn, Dept Mech Engn & Appl Mech, Philadelphia, PA 19104 USA. RP Solanki, KN (reprint author), Arizona State Univ, Sch Engn Matter Transport & Energy, Tempe, AZ 85281 USA. EM kiran.solanki@asu.edu RI Solanki, Kiran/E-8337-2010; OI Tschopp, Mark/0000-0001-8471-5035 FU Office of Naval Research [N000141110793]; U.S. Army Research Laboratory (ARL); US Department of Energy; ARL FX The authors acknowledge useful insights and suggestions from Dr. W. Mullins and Dr. A.K. Vasudevan from the Office of Naval Research. This work was supported by the Office of Naval Research, Contract No. N000141110793. M.A.T. acknowledges the support of the U.S. Army Research Laboratory (ARL) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and ARL. NR 78 TC 20 Z9 20 U1 9 U2 51 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6454 EI 1873-2453 J9 ACTA MATER JI Acta Mater. PD JUL PY 2014 VL 73 BP 312 EP 325 DI 10.1016/j.actamat.2014.04.011 PG 14 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA AJ7BV UT WOS:000337853100029 ER PT J AU Larentzos, JP Brennan, JK Moore, JD Lisal, M Mattson, WD AF Larentzos, James P. Brennan, John K. Moore, Joshua D. Lisal, Martin Mattson, William D. TI Parallel implementation of isothermal and isoenergetic Dissipative Particle Dynamics using Shardlow-like splitting algorithms SO COMPUTER PHYSICS COMMUNICATIONS LA English DT Article DE Dissipative Particle Dynamics; DPD; Shardlow splitting algorithm; Numerical integration; Parallelization ID ENERGY-CONSERVATION; SIMULATIONS; INTEGRATORS; MODELS AB A parallel implementation of the Shardlow splitting algorithm (SSA) for Dissipative Particle Dynamics (DPD) simulations is presented. The isothermal and isoenergetic SSA implementations are compared to the DPD version of the velocity-Verlet integrator in terms of numerical stability and performance. The integrator stability is assessed by monitoring temperature, pressure and total energy for both the standard and ideal DPD fluid models. The SSA requires special consideration due to its recursive nature resulting in more inter-processor communication as compared to traditional DPD integrators. Nevertheless, this work demonstrates that the SSA exhibits stability over longer time steps that justify its regular use in parallel, multi-core applications. For the computer architecture used in this study, a factor of 10-100 speedup is achieved in the overall time-to-solution for isoenergetic DPD simulations and a 15-34 speedup is achieved for the isothermal DPD simulations. 2014 Elsevier B.V. All rights reserved. C1 [Larentzos, James P.] US Army, Ballist Res Lab, Engil Corp, Aberdeen Proving Ground, MD 21005 USA. [Brennan, John K.; Moore, Joshua D.; Mattson, William D.] US Army, Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Lisal, Martin] Acad Sci Czech Republic, Inst Chem Proc Fundamentals, Vvi, E Hala Lab Thermodynam, CR-16502 Prague, Czech Republic. [Lisal, Martin] Univ JE Purkyne, Fac Sci, Dept Phys, Usti Nad Labem, Czech Republic. RP Larentzos, JP (reprint author), US Army, Ballist Res Lab, Engil Corp, Aberdeen Proving Ground, MD 21005 USA. EM James.Larentzos@engilitycorp.com RI Lisal, Martin/A-8176-2011 OI Lisal, Martin/0000-0001-8005-7143 FU Oak Ridge Associated Universities through US Army Research Laboratory; Office of Naval Research [12-001]; Department of Defense High Performance Computing Modernization Program Software Application Institute for Multiscale Reactive Modeling of Insensitive Munitions; Army Research Laboratory [W911NF-10-2-0039] FX The authors would like to thank Jean-Bernard Mail let (Commissariat a l'energie atomique et aux energies alternatives, DAM) and Betsy M. Rice (US Army Research Laboratory) for insightful discussions. JPL and JKB acknowledge Timothy Sirk (US Army Research Laboratory) and Timothy Mattox (Engility Corporation) for useful discussions in parallelizing the Shard low splitting algorithm. The authors acknowledge the computational resources and PETTT software support from the High Performance Computing Modernization office. JDM acknowledges support in part by an appointment to the US Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through a cooperative agreement with the US Army Research Laboratory. JKB and JDM acknowledge support in part by the Office of Naval Research (BAA number 12-001) and the Department of Defense High Performance Computing Modernization Program Software Application Institute for Multiscale Reactive Modeling of Insensitive Munitions. ML acknowledges that this research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-10-2-0039. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the US Government. The US Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 34 TC 5 Z9 5 U1 4 U2 24 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0010-4655 EI 1879-2944 J9 COMPUT PHYS COMMUN JI Comput. Phys. Commun. PD JUL PY 2014 VL 185 IS 7 BP 1987 EP 1998 DI 10.1016/j.cpc.2014.03.029 PG 12 WC Computer Science, Interdisciplinary Applications; Physics, Mathematical SC Computer Science; Physics GA AJ5ZF UT WOS:000337768700015 ER PT J AU Allen, JB AF Allen, J. B. TI Simulations of Anisotropic Grain Growth Involving Two-Phase Nanocrystalline/Amorphous Systems Using Q-State Monte Carlo SO JOURNAL OF ENGINEERING MATERIALS AND TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article ID COMPUTER-SIMULATION; BOUNDARY MOBILITY; MICROSTRUCTURE; EVOLUTION; PHASE; ALGORITHM; COATINGS; KINETICS; FILMS; MODEL AB The present work incorporates an implementation of the two dimensional, Q-state Monte Carlo method to evaluate anisotropic grain growth in two-phase nanocrystalline/amorphous systems. Specifically, anisotropic grain boundaries are simulated via the use of surface energies and binding energies; the former attributable to the variation in grain orientation and assigned through a mapping process involving Wulff plots. The secondary, amorphous phase is randomly assigned to the lattice in accordance with a specified initial volume fraction. Among other findings, the results reveal that the grain boundary surface energy, as governed by the shape of the Wulff plot, plays a critical role in the resulting microstructure. Additionally, it was found that the addition of a secondary amorphous phase to an existing anisotropic grain boundary system evolves into primary grain microstructures characteristic of single phase isotropic systems. C1 US Army Engineer Res & Dev Ctr, Informat Technol Lab, Vicksburg, MS 39180 USA. RP Allen, JB (reprint author), US Army Engineer Res & Dev Ctr, Informat Technol Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM jeffrey.b.allen@erdc.dren.mil NR 35 TC 0 Z9 0 U1 2 U2 13 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0094-4289 EI 1528-8889 J9 J ENG MATER-T ASME JI J. Eng. Mater. Technol.-Trans. ASME PD JUL PY 2014 VL 136 IS 3 AR 031004 DI 10.1115/1.4027323 PG 7 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA AJ7VN UT WOS:000337908000004 ER PT J AU Phadikar, JK Bogetti, TA Karlsson, AM AF Phadikar, J. K. Bogetti, T. A. Karlsson, A. M. TI Aspects of Experimental Errors and Data Reduction Schemes From Spherical Indentation of Isotropic Materials SO JOURNAL OF ENGINEERING MATERIALS AND TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article DE indentation; spherical indentation; sensitivity; condition number; strain hardening ID MEASURING ELASTOPLASTIC PROPERTIES; SENSING INSTRUMENTED INDENTATION; ELASTIC-PLASTIC PROPERTIES; DUAL SHARP INDENTERS; CONICAL INDENTATION; REPRESENTATIVE STRAIN; MECHANICAL-PROPERTIES; RESIDUAL-STRESS; METAL MATERIALS; SENSITIVITY AB Sensitivity to experimental errors determines the reliability and usefulness of any experimental investigation. Thus, it is important to understand how various test techniques are affected by expected experimental errors. Here, a semi-analytical method based on the concept of condition number is explored for systematic investigation of the sensitivity of spherical indentation to experimental errors. The method is employed to investigate the reliability of various possible spherical indentation protocols, providing a ranking of the selected data reduction protocols from least to most sensitive to experimental errors. Explicit Monte Carlo sensitivity analysis is employed to provide further insight of selected protocol, supporting the ranking. The results suggest that the proposed method for estimating the sensitivity to experimental errors is a useful tool. Moreover, in the case of spherical indentation, the experimental errors must be very small to give reliable material properties. C1 [Phadikar, J. K.; Karlsson, A. M.] Univ Delaware, Dept Mech Engn, Newark, DE 19711 USA. [Bogetti, T. A.] US Army Res Lab, Aberdeen, MD 21001 USA. [Karlsson, A. M.] Cleveland State Univ, Washkewicz Coll Engn, Cleveland, OH 44115 USA. RP Karlsson, AM (reprint author), Univ Delaware, Dept Mech Engn, Newark, DE 19711 USA. EM jpha@udel.edu; travis.a.bogetti.civ@mail.mil; a.karlsson@csuohio.edu FU Army Research Laboratory FX The authors would like to thank Dr. Mark R. VanLandingham from Weapons and Materials Research Directorate, Aberdeen Proving Ground, Aberdeen, MD, for useful discussions. This research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement No. W911NF-06-2-011. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. NR 51 TC 0 Z9 0 U1 1 U2 13 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0094-4289 EI 1528-8889 J9 J ENG MATER-T ASME JI J. Eng. Mater. Technol.-Trans. ASME PD JUL PY 2014 VL 136 IS 3 AR 031005 DI 10.1115/1.4027549 PG 8 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA AJ7VN UT WOS:000337908000005 ER PT J AU Cohen, EB Moore, FR Fischer, RA AF Cohen, Emily B. Moore, Frank R. Fischer, Richard A. TI Fuel stores, time of spring, and movement behavior influence stopover duration of Red-eyed Vireo Vireo olivaceus SO JOURNAL OF ORNITHOLOGY LA English DT Article DE Nearctic-Neotropical migrant; Spring migration; Stopover duration; Radio-telemetry; Red-eyed Vireo; Vireo olivaceus ID GULF-OF-MEXICO; MIGRATION STOPOVER; NORTHERN WHEATEARS; ERITHACUS-RUBECULA; OENANTHE-OENANTHE; EUROPEAN ROBINS; FAT DEPOSITION; BIRD MIGRATION; DEPARTURES; MIGRANTS AB Long-distance migration is characterized by periods of flight, when energy stores are consumed, and periods of stopover, when energy stores are replenished. The duration of the migratory period is largely determined by time spent at stopover sites. The time constraints imposed on spring migrants should act to minimize the time spent on migration, yet spring migrants often remain at stopover sites for extended periods. We measured the influence of arrival fuel stores, arrival date, and foraging movement rate on the duration of Red-eyed Vireos (Vireo olivaceus) that remained at stopover sites for more than 1 day. We captured spring migrants in mist-nets as they arrived after crossing the Gulf of Mexico. We released them at an inland site and continuously followed (radio-tracked) their movements until departure. Departure time was confirmed with extensive ground searches and aerial surveys. Migrants remained at the stopover sites from 1 to 8 days (2.80 +/- A 0.14 days). Less than one-third of migrants were transient, leaving the night following release (32 %). Of the migrants that remained more than 1 day, those that arrived with low fuel stores remained longer than those that arrived with more fuel stores. Only migrants arriving early in the spring stayed for extended periods of time (> 5 days). Further, migrants that moved faster within the stopover landscape presumably replenished fuel stores faster because they did not remain as long as migrants that did not move as quickly. When arrival fuel stores, arrival day, and departure day were known, we found multiple factors influenced the length of stay at spring stopover sites. Early spring migrants with low fuel stores that moved slowly through the landscape spent the most time at spring stopover sites. C1 [Cohen, Emily B.; Moore, Frank R.] Univ So Mississippi, Dept Biol Sci, Hattiesburg, MS 39406 USA. [Cohen, Emily B.] Smithsonian Conservat Biol Inst, Migratory Bird Ctr, Washington, DC 20013 USA. [Fischer, Richard A.] US Army Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Cohen, EB (reprint author), Smithsonian Conservat Biol Inst, Migratory Bird Ctr, Natl Zool Pk,POB 37012,MRC 5503, Washington, DC 20013 USA. EM cohene@si.edu FU US Department of Defense Strategic Environmental Research and Development Program; University of Southern Mississippi FX Logistical support was provided by J. Johnson and D. Hudson at Fort Polk and L. Bennett at Louisiana Wildlife and Fisheries. We would especially like to thank the members of the migratory bird research group at USM and all of the hard-working assistants who helped us collect data in the field. Funding for this project was provided by the US Department of Defense Strategic Environmental Research and Development Program and the University of Southern Mississippi. This study was conducted in full compliance with the laws of the United States of America. NR 62 TC 5 Z9 5 U1 0 U2 29 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0021-8375 EI 1439-0361 J9 J ORNITHOL JI J. Ornithol. PD JUL PY 2014 VL 155 IS 3 BP 785 EP 792 DI 10.1007/s10336-014-1067-3 PG 8 WC Ornithology SC Zoology GA AJ6HP UT WOS:000337792500023 ER PT J AU Mayo, JB Wetzel, ED AF Mayo, J. B., Jr. Wetzel, E. D. TI Cut resistance and failure of high-performance single fibers SO TEXTILE RESEARCH JOURNAL LA English DT Article DE cut resistance; single fiber; cutting blade; aramid fiber; S-glass fiber ID TRANSVERSE MECHANICAL-PROPERTIES; SHEAR THICKENING FLUID; BALLISTIC IMPACT; STAB RESISTANCE; FABRICS; STRENGTH; BEHAVIOR; MODULUS; YARNS AB The cut resistance of organic and inorganic high-performance single fibers has been studied. Several fiber types were examined, including Kevlar, Twaron, Vectran, Technora, Zylon, Dyneema, carbon fiber, and S-glass. Experiments were conducted using a custom-designed fixture that forces an industrial cutting blade laterally into a single fiber at varying blade and fiber angles. The effects of cutting angle and fiber type were explored, and the detailed progression of failure was inferred from post-failure imaging. All organic fibers demonstrated similar levels of cut resistance, with both organic and inorganic fibers showing less cut resistance as cutting angle is increased. Failure in the organic fibers was dominated by the anisotropic structure of the fibers. In contrast, isotropic, inorganic glass fibers demonstrated less cutting angle dependence and failed according to simple, localized brittle fracture. The inorganic fibers demonstrated higher average cut resistance than organic fibers, most likely due to their relative hardness and expected higher transverse mechanical properties. C1 [Mayo, J. B., Jr.] Tuskegee Univ, Tuskgee Ctr Adv Mat, Tuskegee, AL 36088 USA. [Mayo, J. B., Jr.; Wetzel, E. D.] US Army Res Lab, Mat & Mfg Sci Div, Adelphi, MD 20783 USA. RP Wetzel, ED (reprint author), US Army Res Lab, Mat & Mfg Sci Div, Adelphi, MD 20783 USA. EM eric.d.wetzel2.civ@mail.mil FU Army Research Office, Battlefield Capability Enhancement Program [W911NF-05-2-0006-P0006] FX This work was supported by the Army Research Office, Battlefield Capability Enhancement Program (grant number W911NF-05-2-0006-P0006). NR 33 TC 4 Z9 5 U1 6 U2 35 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0040-5175 EI 1746-7748 J9 TEXT RES J JI Text. Res. J. PD JUL PY 2014 VL 84 IS 12 BP 1233 EP 1246 DI 10.1177/0040517513517966 PG 14 WC Materials Science, Textiles SC Materials Science GA AJ9GG UT WOS:000338015100001 ER PT J AU Work, D Tong, O Workman, R Katz, A Wissink, AM AF Work, Dalon Tong, Oisin Workman, Ryan Katz, Aaron Wissink, Andrew M. TI Strand-Grid-Solution Procedures for Sharp Corners SO AIAA JOURNAL LA English DT Article ID UNSTRUCTURED MESHES; GENERATION; ACCURACY; FLOWS AB The strand/Cartesian-grid approach provides many advantages for complex moving-body-flow simulations, including fully automatic volume grid generation, highly scalable domain connectivity, and high-order accuracy. In this work, the authors evaluate methods of handling sharp corners with strand grids through combinations of strand vector smoothing, multiple strands emanating from a single surface node, and telescoping Cartesian refinement into corner regions of the near-body grid. A new discretization strategy is introduced to better tolerate mesh skewness induced by strand smoothing. These approaches are tested for unsteady, laminar, and high-Reynolds-number turbulent flows. For standard viscous high-aspect-ratio grids, smoothed strands with telescoping Cartesian refinement provide the most accurate results with the least complexity. Mesh discontinuities associated with the use of multiple strands at sharp corners produce more error than with smoothed strands. With both strand approachesvector smoothing and multiple strands - targeted Cartesian refinement is critical to capture features near sharp corners that strand grids alone are too coarse to capture. C1 [Work, Dalon; Tong, Oisin; Workman, Ryan; Katz, Aaron] Utah State Univ, Dept Mech & Aerosp Engn, Logan, UT 84322 USA. [Wissink, Andrew M.] US Army Aeroflightdynam Directorate, Moffett Field, CA 94035 USA. RP Work, D (reprint author), Utah State Univ, Dept Mech & Aerosp Engn, Logan, UT 84322 USA. RI Katz, Aaron/I-8244-2015 OI Katz, Aaron/0000-0003-2739-9384 FU U.S. Army Research Office Fluid Dynamics Program; U.S. Department of Defense High Performance Computing Modernization Office Computational Research and Engineering for Acquisition Tools and Environments program FX The current work was performed with the support of the U.S. Army Research Office Fluid Dynamics Program, directed by Frederick Ferguson, as well as the U.S. Department of Defense High Performance Computing Modernization Office Computational Research and Engineering for Acquisition Tools and Environments program. NR 39 TC 3 Z9 3 U1 1 U2 2 PU AMER INST AERONAUTICS ASTRONAUTICS PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0001-1452 EI 1533-385X J9 AIAA J JI AIAA J. PD JUL PY 2014 VL 52 IS 7 BP 1528 EP 1541 DI 10.2514/1.J052607 PG 14 WC Engineering, Aerospace SC Engineering GA AJ5SK UT WOS:000337747800016 ER PT J AU George, AA Hixson, CD Peckham, SJ Tyler, D Zelger, B AF George, Alan A. Hixson, Caleb D. Peckham, Steven J. Tyler, Donald Zelger, Bernhard TI A case of oral lichen sclerosus with gingival involvement and Borrelia identification SO HISTOPATHOLOGY LA English DT Letter C1 [George, Alan A.; Hixson, Caleb D.; Peckham, Steven J.; Tyler, Donald] Brooke Army Med Ctr, Dept Pathol, Ft Sam Houston, TX 78234 USA. [Zelger, Bernhard] Med Univ Innsbruck, Dept Dermatol & Venerol, A-6020 Innsbruck, Austria. RP George, AA (reprint author), Brooke Army Med Ctr, Dept Pathol, Ft Sam Houston, TX 78234 USA. NR 9 TC 0 Z9 0 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0309-0167 EI 1365-2559 J9 HISTOPATHOLOGY JI Histopathology PD JUL PY 2014 VL 65 IS 1 BP 146 EP 148 DI 10.1111/his.12363 PG 4 WC Cell Biology; Pathology SC Cell Biology; Pathology GA AJ5BE UT WOS:000337694700018 PM 24387701 ER PT J AU Tateosian, L Mitasova, H Thakur, S Hardin, E Russ, E Blundell, B AF Tateosian, Laura Mitasova, Helena Thakur, Sidharth Hardin, Eric Russ, Emily Blundell, Bruce TI Visualizations of coastal terrain time series SO INFORMATION VISUALIZATION LA English DT Article DE Visualization of time series; temporal visualization; geovisualization; visual perception; visual exploration; visualize changes; geospatial data; three-dimensional visualization; spatial data; visual exploration; space-time cube; geographic information systems; LiDAR; time series; terrain elevation; land surfaces; GIS GRASS ID NORTH-CAROLINA; VISUAL ANALYTICS; LIDAR DATA; SPACE; CUBE AB In coastal regions, water, wind, gravitation, vegetation, and human activity continuously alter landscape surfaces. Visualizations are important for understanding coastal landscape evolution and its driving processes. Visualizing change in highly dynamic coastal terrain poses a formidable challenge; the combination of natural and anthropogenic forces leads to cycles of retreat and recovery and complex morphology of landforms. In recent years, repeated high-resolution laser terrain scans have generated a time series of point cloud data that represent landscapes at snapshots in time, including the impacts of major storms. In this article, we build on existing approaches for visualizing spatial-temporal data to create a collection of perceptual visualizations to support coastal terrain evolution analysis. We extract terrain features and track their migration; we derive temporal summary maps and heat graphs that quantify the pattern of elevation change and sediment redistribution and use the space-time cube concept to create visualizations of terrain evolution. The space-time cube approach allows us to represent shoreline evolution as an isosurface extracted from a voxel model created by stacking time series of digital elevation models. We illustrate our approach on a series of Light Detection and Ranging surveys of sandy North Carolina barrier islands. Our results reveal terrain changes of shoreline and dune ridge migration, dune breaches and overwash, the formation of new dune ridges, and the construction and destruction of homes, changes which are due to erosion and accretion, hurricanes, and human activities. These events are all visualized within their geographic and temporal contexts. C1 [Tateosian, Laura; Mitasova, Helena; Hardin, Eric; Russ, Emily] N Carolina State Univ, Raleigh, NC 27695 USA. [Thakur, Sidharth] Renaissance Comp Inst, Chapel Hill, NC USA. [Blundell, Bruce] US Army, Alexandria, VA USA. RP Tateosian, L (reprint author), N Carolina State Univ, NCSU Campus Box 7106,890 Faucette Dr, Raleigh, NC 27695 USA. EM lgtateos@ncsu.edu OI Mitasova, Helena/0000-0002-6906-3398 FU Army Research Office [W911NF-09-1-0560]; RENCI FX This work was supported in part by a grant W911NF-09-1-0560 from Army Research Office. This work was also supported in part by RENCI. NR 30 TC 1 Z9 3 U1 6 U2 58 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1473-8716 EI 1473-8724 J9 INFORM VISUAL JI Inf. Vis. PD JUL PY 2014 VL 13 IS 3 SI SI BP 266 EP 282 DI 10.1177/1473871613487086 PG 17 WC Computer Science, Software Engineering SC Computer Science GA AJ5GT UT WOS:000337711400006 ER PT J AU Torres, IP Pedro, JRP Narayanan, SV Nguyen, NM Roseff, SD Spiess, BD AF Torres Filho, Ivo P. Pedro, Jose Ricardo P. Narayanan, Srinivasan V. Nguyen, Nguyen M. Roseff, Susan D. Spiess, Bruce D. TI Perfluorocarbon emulsion improves oxygen transport of normal and sickle cell human blood in vitro SO JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A LA English DT Article DE oxygen transport; perfluorocarbon emulsion; oxygen extraction ratio; sickle cell disease; facilitated diffusion; cardiopulmonary bypass ID INVITRO CAPILLARY SYSTEM; EXTRACORPOREAL-CIRCULATION; CARDIOPULMONARY BYPASS; FLUOROCARBON EMULSIONS; HEMORRHAGIC-SHOCK; O-2 TRANSPORT; DELIVERY; HEMOGLOBIN; ERYTHROCYTES; DISEASE AB Perfluorocarbons (PFC) are compounds with high gas solubility that could help deliver O-2 to tissues and have been suggested as adjunct therapy to ischemia. Using a newly designed in vitro system, we tested the hypothesis that a third generation PFC emulsion (Oxycyte) increased O-2 transport of blood by measuring changes in O2 extraction ratio. The system included a computer-controlled pump and blood-gas exchange chambers to oxygenate and deoxygenate the blood from nine sickle cell disease (SCD) patients and five healthy donors. The flowing blood reached various levels of hemoglobin O-2 saturation and O-2 partial pressures (PO2), measured using a CO-oximeter and a blood gas analyzer. The mixtures were kept at physiological blood pressure and temperature, constant flow, normobaric conditions, and FiO2=0.30. After adding PFC, the measurements suggested an increase in the transport of O-2 and CO. Addition of PFC resulted in larger PO2 difference from 15 +/- 2 mmHg to 23 +/- 2 mmHg. Using normal blood and blood from SCD patients, the average O-2 extraction ratio (O2ER) after PFC was significantly higher than baseline. Addition of saline did not cause statistically significant changes. The data suggest increased (facilitated) O-2 transport by this PFC emulsion in both normal and SCD blood. (C) 2013 Wiley Periodicals, Inc. C1 [Torres Filho, Ivo P.; Pedro, Jose Ricardo P.; Narayanan, Srinivasan V.; Nguyen, Nguyen M.] Virginia Commonwealth Univ, Virginia Commonwealth Univ Reanimat Engn Shock Ct, Dept Physiol & Biophys, Richmond, VA 23298 USA. [Torres Filho, Ivo P.; Spiess, Bruce D.] Virginia Commonwealth Univ, Virginia Commonwealth Univ Reanimat Engn Shock Ct, Dept Emergency Med, Richmond, VA 23298 USA. [Torres Filho, Ivo P.] US Army Inst Surg Res, San Antonio, TX 78234 USA. [Roseff, Susan D.] Virginia Commonwealth Univ, Virginia Commonwealth Univ Reanimat Engn Shock Ct, Dept Pathol, Richmond, VA 23298 USA. [Spiess, Bruce D.] Virginia Commonwealth Univ, Virginia Commonwealth Univ Reanimat Engn Shock Ct, Dept Anesthesiol, Richmond, VA 23298 USA. RP Torres, IP (reprint author), Virginia Commonwealth Univ, Virginia Commonwealth Univ Reanimat Engn Shock Ct, Dept Physiol & Biophys, Med Coll Virginia Campus, Richmond, VA 23298 USA. EM ivoptf@msn.com FU Oxygen Biotherapeutics Inc., Virginia Commonwealth University; Universidade do Estado do Rio de Janeiro (to Ivo Torres Filho) FX Contract grant sponsor: Oxygen Biotherapeutics Inc., Virginia Commonwealth University Contract grant sponsor: Universidade do Estado do Rio de Janeiro (to Ivo Torres Filho) NR 41 TC 1 Z9 1 U1 3 U2 17 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1549-3296 EI 1552-4965 J9 J BIOMED MATER RES A JI J. Biomed. Mater. Res. Part A PD JUL PY 2014 VL 102 IS 7 BP 2105 EP 2115 DI 10.1002/jbm.a.34885 PG 11 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA AJ3MJ UT WOS:000337570400006 PM 23894124 ER PT J AU Whalley, MS Takahashi, MD Fletcher, JW Moralez, E Ott, CR Olmstead, MG Savage, JC Goerzen, CL Schulein, GJ Burns, HN Conrad, B AF Whalley, Matthew S. Takahashi, Marc D. Fletcher, Jay W. Moralez, Ernesto, III Ott, Carl R. Olmstead, Michael G. Savage, James C. Goerzen, Chad L. Schulein, Gregory J. Burns, Hoyt N. Conrad, Bill TI Autonomous Black Hawk in Flight: Obstacle Field Navigation and Landing-site Selection on the RASCAL JUH-60A SO JOURNAL OF FIELD ROBOTICS LA English DT Article AB This paper describes the development and flight test of autonomous obstacle field navigation and safe landing area selection on the U. S. Army Aeroflightdynamics Directorate RASCAL JUH-60A research helicopter. Using laser detection and ranging (LADAR) as the primary terrain sensor, the autonomous flight system is able to avoid obstacles, including wires, and select safe landing sites. An autonomous integrated landing zone approach profile was developed and validated that integrates cruise flight, low-level terrain flight, and approach to a safe landing spot determined on the fly. Results are presented for a range of sites and conditions. Approximately 750 km of autonomous flight was performed, 230 km of which was at low altitude in mountainous terrain using the obstacle field navigation system. This is the first time a full-scale helicopter has been flown fully autonomously a significant distance in low-level flight over complex terrain, basing its planning solely on sensor data gathered from an onboard sensor. These flights demonstrate tight integration between terrain avoidance, control, and autonomous landing. (C) 2014 Wiley Periodicals, Inc. C1 [Whalley, Matthew S.; Takahashi, Marc D.; Fletcher, Jay W.; Moralez, Ernesto, III; Ott, Carl R.; Olmstead, Michael G.] US Army, Aviat Dev Directorate AFDD Aviat & Missile Res De, Dev & Engn Command, Moffett Field, CA 94035 USA. [Savage, James C.] US Air Force, Res Lab, Weap Seeker Sci Branch AFRL RWWS, Eglin AFB, FL 32542 USA. [Goerzen, Chad L.; Schulein, Gregory J.] San Jose State Univ, Ames Res Ctr, Moffett Field, CA 94035 USA. [Burns, Hoyt N.; Conrad, Bill] HN Burns Engn Corp, Orlando, FL 32826 USA. RP Goerzen, CL (reprint author), San Jose State Univ, Ames Res Ctr, Moffett Field, CA 94035 USA. EM chad.l.goerzen.ctr@mail.mil NR 31 TC 3 Z9 3 U1 3 U2 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1556-4959 EI 1556-4967 J9 J FIELD ROBOT JI J. Field Robot. PD JUL-AUG PY 2014 VL 31 IS 4 SI SI BP 591 EP 616 DI 10.1002/rob.21511 PG 26 WC Robotics SC Robotics GA AJ4WI UT WOS:000337679200007 ER PT J AU Belenkiy, SM Berry, JS Batchinsky, AI Kendrick, C Necsoiu, C Jordan, BS Salinas, J Cancio, LC AF Belenkiy, Slava M. Berry, John S. Batchinsky, Andriy I. Kendrick, Chonna Necsoiu, Corina Jordan, Bryan S. Salinas, Jose Cancio, Leopoldo C. TI THE NONINVASIVE CARBON DIOXIDE GRADIENT (NICO(2)G) DURING HEMORRHAGIC SHOCK SO SHOCK LA English DT Article DE Transcutaneous carbon dioxide; end-tidal carbon dioxide; noninvasive carbon dioxide gradient; blood gas analysis; hemorrhage; swine ID END-TIDAL CO2; CRITICALLY-ILL; CARDIOPULMONARY-RESUSCITATION; TRANSCUTANEOUS OXYGEN; GENERAL-ANESTHESIA; CIRCULATORY SHOCK; TISSUE HYPOXIA; ARTERIAL PCO2; SERUM LACTATE; CAPNOGRAPHY AB Hemorrhagic shock (HS) is a setting in which both pulmonary and cutaneous perfusion may be impaired. The goals of this study were to evaluate the relationship between end-tidal (etCO(2)), transcutaneous (tPCO(2)), arterial carbon dioxide (PaCO2) and lactate during lethal HS and to assess the effect of progressive HS on those variables and on a new variable, the noninvasive CO2 gradient ([NICO(2)G] or the difference between tPCO(2) and etCO(2)). Ten consciously sedated swine were hemorrhaged, by means of a computerized exponential protocol, of up to 80% estimated blood volume for 20 min. End-tidal carbon dioxide, tPCO(2), PaCO2, and lactate measurements were taken at baseline and every 5 min thereafter, that is, after 25%, 44%, and 62% total blood volume hemorrhage (TBVH) and at cardiac arrest. Cardiac arrest occurred on average at 67% TBVH. Data were analyzed by linear regression and one-way repeated-measures analysis of variance and are presented as means +/- SD. Forty-nine paired measurements were made. There was no overall relationship between NICO2 variables and PaCO2: PaCO2 vs. tPCO(2) (r(2) = 0.002, P = 0.78); PaCO2 vs. etCO(2) (r(2) = 0.0002, P = 0.93). Rather, NICO(2)G increased at each level of blood loss: 4.0 +/- 24.9 at baseline, 6.3 +/- 35.7 at 25% TBVH, 25.0 +/- 37.6 at 44% TBVH, 55.0 +/- 33.9 at 62% TBVH, and 70.0 +/- 33.2 at cardiac arrest (P < 0.05). Similarly, tPCO(2) increased and etCO(2) decreased at each level. Linear regression of NICO(2)G and lactate showed a better correlation than was observed for the other two variables: NICO(2)G, r(2) = 0.58; tPCO(2), r(2) = 0.46; etCO(2), r(2) = 0.26. During HS, NICO2 monitors lose accuracy for approximating the PaCO2 but gain usefulness as hemodynamic monitors. Also, by combining data from two different organ systems, NICO(2)G demonstrated improved correlation with lactate than did either etCO(2) or tPCO(2) alone. C1 [Belenkiy, Slava M.; Berry, John S.; Batchinsky, Andriy I.; Kendrick, Chonna; Necsoiu, Corina; Jordan, Bryan S.; Salinas, Jose; Cancio, Leopoldo C.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Berry, John S.; Kendrick, Chonna] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. RP Belenkiy, SM (reprint author), US Army Inst Surg Res, JBSA, 3650 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM slava.m.belenkiy.vol@mail.mil FU Oridion, Inc.; US Army Institute of Surgical Research; Combat Critical Care Engineering Task Area, Combat Casualty Care Research Area Directorate, US Army Medical Research and Materiel Command FX This study was supported by Oridion, Inc., under a Cooperative Research and Development Agreement with the US Army Institute of Surgical Research. This study was funded by the Combat Critical Care Engineering Task Area, Combat Casualty Care Research Area Directorate, US Army Medical Research and Materiel Command. NR 34 TC 3 Z9 3 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUL PY 2014 VL 42 IS 1 BP 38 EP 43 DI 10.1097/SHK.0000000000000177 PG 6 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA AJ5CZ UT WOS:000337700600008 PM 24667626 ER PT J AU Soller, B Smith, C Zou, F Ellerby, GEC Prince, MD Sondeen, JL AF Soller, Babs Smith, Charles Zou, Fengmei Ellerby, Gwenn E. C. Prince, M. Dale Sondeen, Jill L. TI INVESTIGATION OF NONINVASIVE MUSCLE PH AND OXYGEN SATURATION DURING UNCONTROLLED HEMORRHAGE AND RESUSCITATION IN SWINE SO SHOCK LA English DT Article DE Hemorrhage; fluid resuscitation; NIRS; noninvasive monitoring; acidosis; oxygen debt ID NEAR-INFRARED SPECTROSCOPY; INITIAL RESUSCITATION; COMBAT CASUALTY; SHOCK; OUTCOMES; MODEL AB This study evaluated noninvasively determined muscle pH (pHm) and muscle oxygen saturation (SmO2) in a swine shock model that used uncontrolled hemorrhage and restricted volume resuscitation. Anesthetized 40-kg female swine underwent hemorrhage until 24 mL/kg of blood was removed (n = 26), followed by transection of the spleen, causing uncontrolled hemorrhage throughout the remainder of the protocol. After 15 min, 15 mL/kg of resuscitation fluid (Hextend, fresh-frozen plasma or platelets) was given for 30 min. Arterial and venous blood gases were measured at baseline, shock, end of resuscitation, and end of the study (death or 5 h), along with lactate and base excess. In addition, seven animals underwent a sham procedure. Spectra were collected continuously from the posterior thigh using a prototype CareGuide 1100 Oximeter, and pHm and SmO2 were calculated from the spectra. A two-factor analysis of variance with repeated measures followed by Tukey post hoc comparisons was used to compare experimental factors. It was shown that, for both pH and SO2, venous and muscle values were similar to each other at the end of the resuscitation period and at the end of the study for both surviving and nonsurviving animals. pH and SO2, venous and muscle, significantly declined as a result of bleeding, but lactate and base excess did not show significant changes during this period. Noninvasive pHm and SmO2 tracked the adequacy of resuscitation in real time, indicating at the time all of the fluid was delivered, which animals would live and which would die. The results of this swine study indicate that further evaluation on trauma patients is warranted. C1 [Soller, Babs; Smith, Charles; Zou, Fengmei; Ellerby, Gwenn E. C.] Reflectance Med Inc, Westborough, MA 01581 USA. [Prince, M. Dale; Sondeen, Jill L.] US Army Inst Surg Res, San Antonio, TX USA. RP Soller, B (reprint author), Reflectance Med Inc, 116 Flanders Rd,Suite 1000, Westborough, MA 01581 USA. EM babs.soller@reflectancemedical.com FU US Army Medical Research and Materiel Command (USAMRMC) [W81XWH-11-C-0001]; USAMRMC; Defense Medical Research and Development Program FX This study was supported by the US Army Medical Research and Materiel Command (USAMRMC) (contract no. W81XWH-11-C-0001), by the USAMRMC Core Funds, and by the Defense Medical Research and Development Program. The views, opinions, and/or findings contained in this report are those of the author(s) and should not be construed as an official Department of the Army position, policy, or decision unless so designated by other documentation. NR 19 TC 2 Z9 2 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUL PY 2014 VL 42 IS 1 BP 44 EP 51 DI 10.1097/SHK.0000000000000174 PG 8 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA AJ5CZ UT WOS:000337700600009 PM 24667624 ER PT J AU Wang, GX Murphy, D Oller, A Howard, HR Anderson, AB Rijal, S Myers, NR Woodford, P AF Wang, Guangxing Murphy, Dana Oller, Adam Howard, Heidi R. Anderson, Alan B. Rijal, Santosh Myers, Natalie R. Woodford, Philip TI Spatial and Temporal Assessment of Cumulative Disturbance Impacts Due to Military Training, Burning, Haying, and Their Interactions on Land Condition of Fort Riley SO ENVIRONMENTAL MANAGEMENT LA English DT Article DE Cumulative impacts; Installation; Land condition; Military training; Other human activities; Spatial and temporal assessment; Remote sensing ID LONG-TERM DISTURBANCE; MANEUVER DISTURBANCE; TALLGRASS PRAIRIE; TRACKED VEHICLES; PREDICT PATTERNS; MIXED PRAIRIE; SOIL; METHODOLOGY; VEGETATION; INSTALLATIONS AB The effects of military training activities on the land condition of Army installations vary spatially and temporally. Training activities observably degrade land condition while also increasing biodiversity and stabilizing ecosystems. Moreover, other anthropogenic activities regularly occur on military lands such as prescribed burns and agricultural haying-adding to the dynamics of land condition. Thus, spatially and temporally assessing the impacts of military training, prescribed burning, agricultural haying, and their interactions is critical to the management of military lands. In this study, the spatial distributions and patterns of military training-induced disturbance frequency were derived using plot observation and point observation-based method, at Fort Riley, Kansas from 1989 to 2001. Moreover, spatial and variance analysis of cumulative impacts due to military training, burning, haying, and their interactions on the land condition of Fort Riley were conducted. The results showed that: (1) low disturbance intensity dominated the majority of the study area with exception of concentrated training within centralized areas; (2) high and low values of disturbance frequency were spatially clustered and had spatial patterns that differed significantly from a random distribution; and (3) interactions between prescribed burning and agricultural haying were not significant in terms of either soil erosion or disturbance intensity although their means and variances differed significantly between the burned and non-burned areas and between the hayed and non-hayed areas. C1 [Wang, Guangxing; Murphy, Dana; Oller, Adam; Rijal, Santosh] So Illinois Univ, Dept Geog & Environm Resources, Carbondale, IL 62901 USA. [Howard, Heidi R.; Anderson, Alan B.; Myers, Natalie R.] ERDC CERL, Champaign, IL 61822 USA. [Woodford, Philip] US Army, ATTN AFZN GT RD, Ft Riley, KS USA. RP Wang, GX (reprint author), So Illinois Univ, Dept Geog & Environm Resources, Faner Hall 4520,1000 Faner Dr, Carbondale, IL 62901 USA. EM gxwang@siu.edu FU US Army Corps of Engineers, Construction Engineering Research Laboratory (USA-CERL) [CERL W9132T-08-2-0019-Modification P00003] FX We are grateful to US Army Corps of Engineers, Construction Engineering Research Laboratory (USA-CERL) for providing support (CERL W9132T-08-2-0019-Modification P00003) and data sets for this study and also to the editors and reviewers. NR 45 TC 2 Z9 2 U1 2 U2 14 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0364-152X EI 1432-1009 J9 ENVIRON MANAGE JI Environ. Manage. PD JUL PY 2014 VL 54 IS 1 BP 51 EP 66 DI 10.1007/s00267-014-0284-0 PG 16 WC Environmental Sciences SC Environmental Sciences & Ecology GA AI9UP UT WOS:000337285900006 PM 24817335 ER PT J AU Hannah, ST Sumanth, JJ Lester, P Cavarretta, F AF Hannah, Sean T. Sumanth, John J. Lester, Paul Cavarretta, Fabrice TI Debunking the false dichotomy of leadership idealism and pragmatism: Critical evaluation and support of newer genre leadership theories SO JOURNAL OF ORGANIZATIONAL BEHAVIOR LA English DT Review DE leadership; transformational; ethical; authentic; servant; spiritual; moral; performative ID TRANSFORMATIONAL LEADERSHIP; ETHICAL LEADERSHIP; AUTHENTIC LEADERSHIP; BEHAVIORAL INTEGRITY; METAANALYTIC TEST; FIELD EXPERIMENT; RESEARCH AGENDA; MULTIDIMENSIONAL MEASURE; ORGANIZATIONAL-BEHAVIOR; SPIRITUAL LEADERSHIP AB Leadership theories have shifted over the last few decades from a focus on managerial functions and economic leader-follower exchanges toward greater focus on the interpersonal dynamics occurring within the leadership process. Theories such as transformational, ethical, authentic, and other newer genre theories were created to address neglected topics such as leader vision and inspirational messages, transparency, emotional effects, morality, individualized attention, and intellectual stimulation. Critiques of these theories, however, have been raised. In this paper, we address five of those critiques and argue for the validity and practical effectiveness of the new genre theories. Further, we describe how newer genre leadership research should be viewed as a performative epistemology, entailing a process of co-creation involving scholars and practitioners. Finally, from this view, we provide general ideas for leader development. Copyright (c) 2014 John Wiley & Sons, Ltd. C1 [Hannah, Sean T.; Sumanth, John J.] Wake Forest Univ, Winston Salem, NC 27109 USA. [Lester, Paul] US Army, Res Facilitat Team, Off Deputy Secretary Army, Monterey, CA USA. [Cavarretta, Fabrice] ESSEC Business Sch, Paris, France. RP Sumanth, JJ (reprint author), Wake Forest Univ, Sch Business, Suite 388,Farrell Hall,Bldg 60, Winston Salem, NC 27109 USA. EM sumanthj@wfu.edu NR 148 TC 5 Z9 5 U1 17 U2 98 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0894-3796 EI 1099-1379 J9 J ORGAN BEHAV JI J. Organ. Behav. PD JUL PY 2014 VL 35 IS 5 BP 598 EP 621 DI 10.1002/job.1931 PG 24 WC Business; Psychology, Applied; Management SC Business & Economics; Psychology GA AJ4HT UT WOS:000337636000002 ER PT J AU Han, ZY Lu, JH Liu, YL Davis, B Lee, MS Olson, MA Ruthel, G Freedman, BD Schnell, MJ Wrobel, JE Reitz, AB Harty, RN AF Han, Ziying Lu, Jianhong Liu, Yuliang Davis, Benjamin Lee, Michael S. Olson, Mark A. Ruthel, Gordon Freedman, Bruce D. Schnell, Matthias J. Wrobel, Jay E. Reitz, Allen B. Harty, Ronald N. TI Small-Molecule Probes Targeting the Viral PPxY-Host Nedd4 Interface Block Egress of a Broad Range of RNA Viruses SO JOURNAL OF VIROLOGY LA English DT Article ID VESICULAR-STOMATITIS-VIRUS; PROTEIN-PROTEIN INTERACTIONS; LATE BUDDING DOMAINS; ROUS-SARCOMA-VIRUS; EBOLA-VIRUS; MARBURG-VIRUS; MATRIX PROTEIN; UBIQUITIN LIGASE; LASSA VIRUS; WW DOMAINS AB Budding of filoviruses, arenaviruses, and rhabdoviruses is facilitated by subversion of host proteins, such as Nedd4 E3 ubiquitin ligase, by viral PPxY late (L) budding domains expressed within the matrix proteins of these RNA viruses. As L domains are important for budding and are highly conserved in a wide array of RNA viruses, they represent potential broad-spectrum targets for the development of antiviral drugs. To identify potential competitive blockers, we used the known Nedd4 WW domain-PPxY interaction interface as the basis of an in silico screen. Using PPxY-dependent budding of Marburg (MARV) VP40 virus-like particles (VLPs) as our model system, we identified small-molecule hit 1 that inhibited Nedd4-PPxY interaction and PPxY-dependent budding. This lead candidate was subsequently improved with additional structure-activity relationship (SAR) analog testing which enhanced antibudding activity into the nanomolar range. Current lead compounds 4 and 5 exhibit on-target effects by specifically blocking the MARV VP40 PPxY-host Nedd4 interaction and subsequent PPxY-dependent egress of MARV VP40 VLPs. In addition, lead compounds 4 and 5 exhibited antibudding activity against Ebola and Lassa fever VLPs, as well as vesicular stomatitis and rabies viruses (VSV and RABV, respectively). These data provide target validation and suggest that inhibition of the PPxY-Nedd4 interaction can serve as the basis for the development of a novel class of broad-spectrum, host-oriented antivirals targeting viruses that depend on a functional PPxY L domain for efficient egress. C1 [Han, Ziying; Lu, Jianhong; Liu, Yuliang; Ruthel, Gordon; Freedman, Bruce D.; Harty, Ronald N.] Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA. [Davis, Benjamin; Schnell, Matthias J.] Thomas Jefferson Univ, Dept Microbiol & Immunol, Philadelphia, PA 19107 USA. [Lee, Michael S.; Olson, Mark A.] US Army Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD USA. [Lee, Michael S.] US Army Res Lab, Simulat Sci Branch, Aberdeen Proving Ground, MD USA. [Wrobel, Jay E.; Reitz, Allen B.] Fox Chase Chem Div Ctr Inc, Doylestown, PA USA. RP Harty, RN (reprint author), Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA. EM rharty@vet.upenn.edu FU NIH/NIAID [AI102104, U54-AI057168] FX This work was supported in part by NIH/NIAID grants AI102104 and U54-AI057168 to R.N.H. NR 88 TC 22 Z9 25 U1 1 U2 28 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X EI 1098-5514 J9 J VIROL JI J. Virol. PD JUL PY 2014 VL 88 IS 13 BP 7294 EP 7306 DI 10.1128/JVI.00591-14 PG 13 WC Virology SC Virology GA AI9GN UT WOS:000337240700017 PM 24741084 ER PT J AU Schieffer, M Jessen, HK Oster, AF Pissani, F Soghoian, DZ Lu, R Jessen, AB Zedlack, C Schultz, BT Davis, I Ranasinghe, S Rosenberg, ES Alter, G Schumann, RR Streeck, H AF Schieffer, Miriam Jessen, Heiko K. Oster, Alexander F. Pissani, Franco Soghoian, Damien Z. Lu, Richard Jessen, Arne B. Zedlack, Carmen Schultz, Bruce T. Davis, Isaiah Ranasinghe, Srinika Rosenberg, Eric S. Alter, Galit Schumann, Ralf R. Streeck, Hendrik TI Induction of Gag-Specific CD4 T Cell Responses during Acute HIV Infection Is Associated with Improved Viral Control SO JOURNAL OF VIROLOGY LA English DT Article ID IN-VIVO; VIRUS; SUPERINFECTION; MAINTENANCE; PROTECTION; INFLUENZA; KINETICS; DISEASE; VIREMIA AB Effector CD4 T cell responses have been shown to be critically involved in the containment and clearance of viral pathogens. However, their involvement in the pathogenesis of HIV infection is less clear, given their additional role as preferred viral targets. We previously demonstrated that the presence of HIV-specific CD4 T cell responses is somewhat associated with HIV control and that specific CD4 T cell functions, such as direct cytolytic activity, can contribute to control of HIV viremia. However, little is known about how the induction of HIV-specific CD4 T cell responses during acute HIV infection influences disease progression and whether responses induced during the early phase of infection are preferentially depleted. We therefore longitudinally assessed, in a cohort of 55 acutely HIV-infected individuals, HIV-specific CD4 T cell responses from acute to chronic infection. Interestingly, we found that the breadth, magnitude, and protein dominance of HIV-specific CD4 T cell responses remained remarkably stable over time. Moreover, we found that the epitopes targeted at a high frequency in acute HIV infection were recognized at the same frequency by HIV-specific CD4 T cells in chronic HIV infection. Interestingly the induction of Gag-specific CD4 T cell responses in acute HIV infection was significantly inversely correlated with viral set point in chronic HIV infection (R = -0.5; P = 0.03), while the cumulative contribution of Env-specific CD4 T cell responses showed the reverse effect. Moreover, individuals with HIV-specific CD4 T cell responses dominantly targeting Gag over Env in acute HIV infection remained off antiretroviral therapy significantly longer (P = 0.03; log rank). Thus, our data suggest that the induction of HIV-specific CD4 T cell responses during acute HIV infection is beneficial overall and does not fuel disease progression. C1 [Schieffer, Miriam; Jessen, Heiko K.; Jessen, Arne B.; Zedlack, Carmen; Davis, Isaiah] HIV Clin Praxis Jessen, Berlin, Germany. [Oster, Alexander F.; Pissani, Franco; Lu, Richard; Schultz, Bruce T.; Streeck, Hendrik] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Oster, Alexander F.; Pissani, Franco; Lu, Richard; Schultz, Bruce T.; Streeck, Hendrik] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Soghoian, Damien Z.; Ranasinghe, Srinika; Alter, Galit; Streeck, Hendrik] MIT, Ragon Inst MGH, Cambridge, MA 02139 USA. [Soghoian, Damien Z.; Ranasinghe, Srinika; Alter, Galit; Streeck, Hendrik] Harvard Univ, Cambridge, MA 02138 USA. [Rosenberg, Eric S.] Massachussetts Gen Hosp, Boston, MA USA. [Schieffer, Miriam; Schumann, Ralf R.] Charite Univ Med Ctr, Inst Microbiol & Hyg, Berlin, Germany. RP Streeck, H (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. EM hstreeck@hivresearch.org FU U.S. National Institutes of Health (NIH) [R01 AI091450-01, R01 AI094602-01, P01 AI074415]; Bill and Melinda Gates Foundation FX This study was funded by the U.S. National Institutes of Health (NIH) (R01 AI091450-01, R01 AI094602-01, and P01 AI074415) and supported by the Bill and Melinda Gates Foundation. NR 36 TC 9 Z9 9 U1 0 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X EI 1098-5514 J9 J VIROL JI J. Virol. PD JUL PY 2014 VL 88 IS 13 BP 7357 EP 7366 DI 10.1128/JVI.00728-14 PG 10 WC Virology SC Virology GA AI9GN UT WOS:000337240700022 PM 24741089 ER PT J AU Cordero, ZC Huskins, EL Park, M Livers, S Frary, M Schuster, BE Schuh, CA AF Cordero, Zachary C. Huskins, Emily L. Park, Mansoo Livers, Steven Frary, Megan Schuster, Brian E. Schuh, Christopher A. TI Powder-Route Synthesis and Mechanical Testing of Ultrafine Grain Tungsten Alloys SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE LA English DT Article ID PLASMA PRESSURE COMPACTION; NI-W ALLOYS; REFRACTORY-METALS; HIGH-STRAIN; NANOCRYSTALLINE; SIZE; BEHAVIOR; HARDNESS; COMPRESSION; DRAWN AB We report a W-rich alloy (W-7Cr-9Fe, at. pct) produced by high-energy ball milling, with alloying additions that both lower the densification temperature and retard grain growth. The alloy's consolidation behavior and the resultant compacts' microstructure and mechanical properties are explored. Under one condition, a 98 pct dense compact with a mean grain size of 130 nm was achieved, and exhibited a hardness of 13.5 GPa, a dynamic uniaxial yield strength of 4.14 GPa in Kolsky bar experiments, and signs of structural shear localization during deformation. C1 [Cordero, Zachary C.; Park, Mansoo; Schuh, Christopher A.] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA. [Huskins, Emily L.] Army Res Lab, Oak Ridge Inst Sci & Educ, Postdoctoral Fellowship Program, Aberdeen Proving Ground, MD 21005 USA. [Livers, Steven; Frary, Megan] Boise State Univ, Dept Mat Sci & Engn, Boise, ID 83725 USA. [Schuster, Brian E.] Army Res Laboratory, Expt & Computat Penetrat Mech Team, Weap & Mat Res Directorate, Adelphi, MD USA. RP Cordero, ZC (reprint author), MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA. EM schuh@mit.edu FU US Defense Threat Reduction Agency [HDTRA1-11-1-0062]; Department of Defense through the NDSEG fellowship program; US Army Research Laboratory through the Oak Ridge Institute for Space and Education (ORISE) Program [1120-1120-99]; [11-24] FX This study was supported by the US Defense Threat Reduction Agency under Grant No. HDTRA1-11-1-0062. ZCC acknowledges support from the Department of Defense through the NDSEG fellowship program. ELH acknowledges support from the US Army Research Laboratory through the Oak Ridge Institute for Space and Education (ORISE) Program # 1120-1120-99. BES would like to acknowledge support work from the Cooperative Research and Development Agreement #11-24. We would like to thank Ms. Alexandria Will-Cole for her indentation work on the intermetallic phase, Dr. Kisub Cho for performing the THERMOCALC calculations, and Dr. Daniel T. Casem for his assistance with the Kolsky bar tests. NR 58 TC 3 Z9 3 U1 5 U2 33 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1073-5623 EI 1543-1940 J9 METALL MATER TRANS A JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci. PD JUL PY 2014 VL 45A IS 8 BP 3609 EP 3618 DI 10.1007/s11661-014-2286-1 PG 10 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA AI7MX UT WOS:000337076900043 ER PT J AU Willey, LN Netherland, MD Haller, WT Langeland, KA AF Willey, Leif N. Netherland, Michael D. Haller, William T. Langeland, Kenneth A. TI Evaluation of aquatic herbicide activity against crested floating heart SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE endothall; foliar; imazapyr; imazamox; Nymphoides; subsurface AB Crested floating heart [Nymphoides cristata (Roxb.) Kuntze] is a rapidly spreading invasive aquatic plant found in the southeastern United States. This plant exhibits a nymphaeid growth form producing dense mats of overlapping, floating leaves at the end of long stems in water up to 3 m in depth. To date, most operational strategies have relied on aquatic herbicides; however, results have been inconsistent and anecdotal. The objective of this research was to evaluate the majority of registered aquatic herbicides for activity against crested floating heart. A series of small-scale tank experiments was conducted to determine efficacy of the active ingredients: (2,4-dichlorophenoxy)acetic acid (2,4-D), [(3,5,6-trichloro-2-pyridinyl)oxy]acetic acid (triclopyr), 7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid (endothall), 6,7-dihydrodipyrido[1,2-alpha:2',1'-c]pyrazinediium ion (diquat), X,2-dichloro-544-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4-triazol-1-yl]-4-fluorobenzenepropanoic acid (carfentrazone), 2-[7-fluoro-3,4-dihydro-3-oxo-4-(2-propanyl)-2H-1,4-benzoxazin-6-yl]-4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dione (flumioxazin), 2,6-bis[(4,6-dimethoxy-2-pyrimidinyl)oxy]benzoic acid (bispyribac-sodium), N-(phosphonomethyl)glycine (glyphosate), 2-[4,5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1H-imidazol-2-yl]-5-(methoxymethyl)-3-pyridinecarboxylic acid (imazamox), (+/-)-2-[4,5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1H-imidazol- 2-yl]-3-pyridinecarboxylic acid (imazapyr), and 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide (penoxsulam) applied via foliar and subsurface applications. Herbicides were applied at concentrations near maximum and half-maximum label use rates in the late spring through summer on plants that had formed a surface canopy. The submersed treatments were evaluated at 24 and 96-h exposure periods. Harvest at 4 wk after treatment indicated that most of the herbicides were not active after either the 24 or 96-h exposure at the highest test rate. In contrast, the liquid subsurface treatments of endothall at 0.25 and 0.5 mg ae L-1 provided complete control after 24 and 96-h exposures, whereas diquat at 0.18 and 0.37 mg ai L-1 provided 91 to 95% control after a 96-h exposure. Endothall also provided 24 to 60% biomass reductions after granular applications of 3 mg ae L-1 for a 96-h exposure. Foliarapplied imazamox and imazapyr at 1.2 kg ai ha(-1) provided similar levels of control ranging from 81 to 83% control respectively. The other foliar-applied herbicides, including 2,4-D, triclopyr, and glyphosate, were not effective. For herbicides tested as both foliar and submersed applications, it was found that method of application had limited impact on activity and efficacy. Furthermore, aside from the amine salt of endothall, we did not detect a difference between liquid and granular formulations for submersed applications. These data indicate that most of the herbicides tested had limited activity on crested floating heart in our experimental system. These results suggest the amine salt of endothall and diquat as submersed applications and imazapyr and imazamox as foliar applications were the most effective. Further testing is needed to determine optimal timing, use rates, and products for efficacy under field conditions. C1 [Willey, Leif N.; Haller, William T.; Langeland, Kenneth A.] Univ Florida, Inst Food & Agr Sci, Ctr Aquat & Invas Plants, Agron, Gainesville, FL 32653 USA. [Netherland, Michael D.] US Army Engineer Res & Dev Ctr, Ctr Aquat & Invas Plants, Gainesville, FL 32653 USA. RP Willey, LN (reprint author), Univ Florida, Inst Food & Agr Sci, Ctr Aquat & Invas Plants, Agron, 7922 NW 71st St, Gainesville, FL 32653 USA. EM lwilley@ufl.edu FU Florida Fish and Wildlife Commission; Midwest Aquatic Plant Management Society; Aquatic Ecosystem Restoration Foundation FX Funding for this project was provided by the Florida Fish and Wildlife Commission, Invasive Plant Management section. Additional support was provided to L.N.W. with a student research grant from the Midwest Aquatic Plant Management Society and a grant from the Aquatic Ecosystem Restoration Foundation provided to the University of Florida Center for Aquatic and Invasive Plants to support graduate student projects. We also thank G. Hoyer and Z. Banks for assisting with data collection and maintaining plant stocks. NR 27 TC 3 Z9 3 U1 0 U2 5 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2014 VL 52 BP 47 EP 56 PG 10 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA V41TD UT WOS:000209567600003 ER PT J AU Netherland, MD Glomski, LM AF Netherland, Michael D. Glomski, Leeann M. TI Mesocosm evaluation of triclopyr on Eurasian watermilfoil and three native submersed species: The role of treatment timing and herbicide exposure SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE aquatic herbicides; invasive aquatic plants; SAV; Submersed Aquatic Vegetation AB Early-season recommendations to improve herbicide efficacy and selectivity when targeting Eurasian watermilfoil (Myriophyllum spicatum L.) have been adopted by many aquatic plant managers in the upper Midwest. To address the role of treatment timing and exposure, two mesocosm studies were conducted on plants established the prior fall to evaluate short- and long-term exposure scenarios when the auxin mimic herbicide triclopyr ([3,5,6-trichloro-2-pyridinyl)oxy]acetic acid) is used for selective control of Eurasian watermilfoil (EWM). The first study included liquid and granular triclopyr applied at 1.5 mg L-1 in late February and late April 2009 under high-water-exchange conditions (12-h half-life). The second trial included static liquid exposures for early March and late April 2011 treatments at use rates of 0.25, 0.5, and 1.5 mg L-1 and liquid and granular treatments at 1.5 mg L-1 under high-waterexchange conditions (5-h half-life). The second study also included the native species American pondweed (Potamogeton nodosus Poir.), Illinois pondweed (P. illinoensis Morong), and vallisneria (Vallisneria americana Michx.). In the first study, February triclopyr treatments with liquid and granular formulations did not reduce biomass compared to the untreated plants during a May harvest, whereas both April treatments resulted in complete control of EWM. Results of the second trial indicated that treatment timing (March vs. April) was not a significant factor for static treatments (0.25 to 1.5 mg L-1) and near 100% EWM control was achieved. In contrast, under high flow conditions, the March liquid treatment did not differ from the untreated reference plants. The granular treatment reduced EWM by 55% compared to the untreated reference, yet it still increased in biomass by 4-fold compared to the initial biomass. The April treatments were more effective than the March applications under conditions of high water exchange. The native plants evaluated were not impacted by treatment timing, rate, formulation, or exposure scenario. Results demonstrate early-season treatments were effective regardless of treatment timing under extended triclopyr exposure periods; however, in areas of high-water-exchange early treatments of EWM resulted in reduced plant control. Managers can use this information to determine if early- or later-season treatments are warranted based on the likely exposure scenario. C1 [Netherland, Michael D.] US Army Engineer Res & Dev Ctr, Ctr Aquat & Invas Plants, Gainesville, FL 32653 USA. [Glomski, Leeann M.] US Army Engineer Res & Dev Ctr, Lewisville Aquat Ecosyst Res Facil, Lewisville, TX 75057 USA. RP Netherland, MD (reprint author), US Army Engineer Res & Dev Ctr, Ctr Aquat & Invas Plants, Gainesville, FL 32653 USA. EM mdnether@ufl.edu NR 21 TC 2 Z9 2 U1 2 U2 3 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2014 VL 52 BP 57 EP 64 PG 8 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA V41TD UT WOS:000209567600004 ER PT J AU Mudge, CR Netherland, MD AF Mudge, Christopher R. Netherland, M. D. TI Response of giant bulrush, water hyacinth, and water lettuce to foliar herbicide applications SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE 2,4-D; chemical control; diquat; Eichhornia crassipes; flumioxazin; glyphosate; imazamox; penoxsulam; Pistia stratiotes; Schoenoplectus californicus; selectivity; triclopyr AB The aquatic herbicides 2,4-D (2,4-dichlorophenoxyacetic acid) and diquat (6,7-dihydrodipyrido [1,2-a : 2',1'-c]pyraziriediium ion) are commonly used to control the invasive floating plants water hyacinth (Eichhornia crassipes [Mart.] So lms) and water lettuce (Pistia stratiotes L.). Despite the high level of efficacy and rapid injury markers from these foliarapplied herbicides, nontarget injury is common when these herbicides are applied to mixed populations of target and nontarget emergent plant species. Therefore, a series of trials were conducted to find additional herbicides that can selectively control water hyacinth and water lettuce. Giant bulrush (hard-stem bulrush, Schoenoplectus californicus [C.A. Mey] Palla) shoot biomass was not reduced by the aquatic herbicides flumioxazin (2[7-fluoro-3,4-dihydro- 3-oxo-4-(2propynyl)-2H-1,4-benzoxazin-6-yl]-4,5,6,7-tetrahydro-1H- isoindole-1,3[2H]-dione), imazamox (2-[4,5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1 H-imidazol-2-yl]-5- [methoxymethyl]-3-pyridinecarboxylic acid), and penoxsulam (2-[2,2-difluoroethoxy]-N-(5,8-dimethoxy [1,2,4]triazolo[1,5- c] pyrimidin-2-yl)-6-[trifluoromethyl] benzenesulfonamide) 8 wk after treatment (WAT). Conversely, 2,4-D, diquat, glyphosate (N-[phosphonomethyl]glycine), triclopyr (3,5,6- trichloro-2-pyridinyloxyacetic acid), and 2,4-D plus diquat reduced plant dry weight 49 to 97%. In the water hyacinth screening trial, all herbicide treatments except flumioxazin resulted in 76 to 100% control. Water lettuce dry weight was reduced >61% by all foliar herbicide treatments, with the exception of 2,4-D and triclopyr. Although imazamox and penoxsulam were efficacious against the target species, noticeable injury symptoms were slow to develop (1 to 2 wk to occur), and the acetolactate synthase (ALS) herbicides were much slower in controlling the plants compared to other efficacious herbicides evaluated in the screening trial. These results indicate imazamox and penoxsulam may be suitable for selectively managing water hyacinth and water lettuce. C1 [Mudge, Christopher R.] Louisiana State Univ, Sch Plant Environm & Soil Sci, US Army Engineer Res & Dev Ctr, Baton Rouge, LA 70803 USA. [Netherland, M. D.] US Army Engineer Res & Dev Ctr, Ctr Aquat & Invas Plants, Gainesville, FL 32653 USA. RP Mudge, CR (reprint author), Louisiana State Univ, Sch Plant Environm & Soil Sci, US Army Engineer Res & Dev Ctr, Baton Rouge, LA 70803 USA. EM Christopher.R.Mudge@usace.army.mil FU U.S. Army Corps of Engineers Jacksonville District; U.S. Army Aquatic Plant Control Research Program FX This research was supported by the U.S. Army Corps of Engineers Jacksonville District and the U.S. Army Aquatic Plant Control Research Program. Jeremy Crossland and Michael Saucier kindly provided reviews of this manuscript. Permission was granted by the Chief of Engineers to publish this information. Citation of trade names does not constitute endorsement or approval of the use of such commercial products. NR 20 TC 0 Z9 0 U1 1 U2 2 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2014 VL 52 BP 75 EP 80 PG 6 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA V41TD UT WOS:000209567600007 ER PT J AU Glomski, LM Netherland, MD AF Glomski, Leeann M. Netherland, Michael D. TI Response of waterlily, spatterdock, and hardstem bulrush to liquid and granular triclopyr treatments SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article C1 [Glomski, Leeann M.] US Army Engineer Res & Dev Ctr, Lewisville Aquat Ecosyst Res Facil, Lewisville, TX 75057 USA. [Netherland, Michael D.] US Army Engineer Res & Dev Ctr, Ctr Aquat & Invas Plants, Gainesville, FL 32653 USA. RP Glomski, LM (reprint author), US Army Engineer Res & Dev Ctr, Lewisville Aquat Ecosyst Res Facil, 201 E Jones St, Lewisville, TX 75057 USA. EM LeeAnn.M.Glomski@usace.army.mil NR 12 TC 1 Z9 1 U1 2 U2 4 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2014 VL 52 BP 81 EP 84 PG 4 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA V41TD UT WOS:000209567600008 ER PT J AU Wersal, RM Poovey, AG Madsen, JD Getsinger, KD Mudge, CR AF Wersal, Ryan M. Poovey, A. G. Madsen, J. D. Getsinger, K. D. Mudge, C. R. TI . Comparison of late-season herbicide treatments for control of emergent flowering rush in mesocosms SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article C1 [Wersal, Ryan M.] Lonza, Alpharetta, GA 30004 USA. [Poovey, A. G.; Getsinger, K. D.; Mudge, C. R.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Wersal, Ryan M.; Madsen, J. D.] Geosyst Res Inst, Mississippi State, MS 39762 USA. RP Wersal, RM (reprint author), Lonza, 1200 Bluegrass Lakes Pkwy, Alpharetta, GA 30004 USA. EM ryan.wersal@lonza.com NR 21 TC 2 Z9 2 U1 0 U2 3 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2014 VL 52 BP 85 EP 89 PG 5 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA V41TD UT WOS:000209567600009 ER PT J AU Glomski, LM Willey, LN Netherland, MD AF Glomski, Leeann M. Willey, Leif N. Netherland, Michael D. TI The efficacy of protox-inhibiting herbicides alone and in combination with glyphosate to control crested floating heart SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article C1 [Glomski, Leeann M.] US Army Engineer Res & Dev Ctr, Lewisville Aquat Ecosyst Res Facil, Lewisville, TX 75057 USA. [Willey, Leif N.] Univ Florida, Gainesville, FL 32653 USA. [Netherland, Michael D.] US Army Engineer Res & Dev Ctr, Ctr Aquat & Invas Plants, Gainesville, FL 32653 USA. RP Glomski, LM (reprint author), US Army Engineer Res & Dev Ctr, Lewisville Aquat Ecosyst Res Facil, 201 E Jones St, Lewisville, TX 75057 USA. EM LeeAnn.M.Glomski@usace.army.mil FU Florida Fish and Wildlife Commission FX Support for this research was provided by the Florida Fish and Wildlife Commission, Invasive Plant Management Section. Citation of trade names does not constitute an official endorsement or approval of the use of such commercial products. Permission was granted by the Chief of Engineers to publish this information. NR 14 TC 3 Z9 3 U1 2 U2 3 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2014 VL 52 BP 90 EP 92 PG 3 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA V41TD UT WOS:000209567600010 ER PT J AU Owens, CS Smart, RM Dick, GO AF Owens, Chetta S. Smart, R. Michael Dick, Gary O. TI Effects of salinity and pH on growth of giant salvinia (Salvinia molesta Mitchell) SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article C1 [Owens, Chetta S.; Smart, R. Michael; Dick, Gary O.] USAE Lewisville Aquat Ecosyst Res Facil, Lewisville, TX 75057 USA. RP Owens, CS (reprint author), USAE Lewisville Aquat Ecosyst Res Facil, 201 E Jones St, Lewisville, TX 75057 USA. EM chetta@laerf.org NR 28 TC 0 Z9 0 U1 1 U2 3 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2014 VL 52 BP 93 EP 96 PG 4 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA V41TD UT WOS:000209567600011 ER PT J AU Ellis, BD DiPaolo, BP McDowell, DL Zhou, M AF Ellis, B. D. DiPaolo, B. P. McDowell, D. L. Zhou, M. TI Experimental investigation and multiscale modeling of ultra-high-performance concrete panels subject to blast loading SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE UHPC; Blast loading; Multiscale modeling ID CEMENTITIOUS COMPOSITES; FIBER; STEEL; BEHAVIOR AB Tailored cementitious materials, such as Ultra-High-Performance Concrete (UHPC), may significantly improve the blast resistance of structural panels. To understand and quantify the performance of UHPC panels subject to blast loading, four 1626- by 864- by 51-mm UHPC panels without steel rebar reinforcement were subjected to reflected impulse loads between 0.77 and 2.05 MPa-ms. The UHPC material was composed of a commercially available UHPC premix, high-range water reducing agent, 2% volume fraction of straight, smooth 14-mm-long by 0.185-mm-diameter fibers, and water. Experimental results determined that the UHPC panel fractured at a reflected impulse between 0.97 and 1.47 MPa-ms. These results were used to validate a multiscale model which accounts for structure and phenomena at two length scales: a multiple fiber length scale and a structural length scale. Within the multiscale model, a hand-shaking scheme conveys the energy barrier threshold and dissipated energy density from the model at the multiple fiber length scale to the model at the structural length scale. Together, the models at the two length scales account for energy dissipation through granular flow of the matrix, frictional pullout of the fibers, and friction between the interfaces. The simulated displacement and fracture patterns generated by the multiscale model are compared to experimental observations. This work is significant for three reasons: (1) new experimental data provide an upper and lower bound to the blast resistance of UHPC panels, (2) the multiscale model simulates the experimental results using readily available material properties and information regarding mesostructure attributes at two different length scales, and (3) by incorporating information from multiple length scales, the multiscale model can facilitate the design of UHPC materials to resist blast loading in ways not accessible using single length scale models. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Ellis, B. D.; McDowell, D. L.; Zhou, M.] Georgia Inst Technol, Woodruff Sch Mech Engn, Atlanta, GA 30332 USA. [DiPaolo, B. P.] US Army, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [McDowell, D. L.; Zhou, M.] Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA. RP Ellis, BD (reprint author), Georgia Inst Technol, Woodruff Sch Mech Engn, Atlanta, GA 30332 USA. EM bellis7@gatech.edu FU Department of Homeland Security; Science and Technology Directorate; Infrastructure Protection and Disaster Management Division: Mila Kennett FX This work was sponsored by the Department of Homeland Security, Science and Technology Directorate, Infrastructure Protection and Disaster Management Division: Mila Kennett, Program Manager. The research was performed under the direction of Dr. Beverly P. DiPaolo, Engineer Research and Development Center (ERDC), U.S. Army Corps of Engineers (USACE). Permission to publish was granted by the Director, Geotechnical and Structures Laboratory, ERDC. Approved for public release; distribution is unlimited. NR 26 TC 10 Z9 11 U1 3 U2 31 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X EI 1879-3509 J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD JUL PY 2014 VL 69 BP 95 EP 103 DI 10.1016/j.ijimpeng.2013.12.011 PG 9 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA AH3FY UT WOS:000336010300009 ER PT J AU Fox, DM Akers, SA Leiste, UH Fourney, WL Windham, JE Lee, JS Ehrgott, JQ Taylor, LC AF Fox, D. M. Akers, S. A. Leiste, U. H. Fourney, W. L. Windham, J. E. Lee, J. S. Ehrgott, J. Q. Taylor, L. C. TI The effects of air filled voids and water content on the momentum transferred from a shallow buried explosive to a rigid target SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Mine blast; Soil mechanics; Shallow-buried explosive; Multi-component flow; Momentum transfer ID PARAMETERS AB Small-scale dynamic experiments were performed using explosive charges shallow buried in water or in various soil types at differing initial states. Using the results from these experiments, it was discovered that the amount of momentum transferred to a rigid target is relatively independent of soil type but that mostly depends on the initial air-filled void content of the soil and the effect of water content on the yield strength of the soil. Data from quasi-static tests of soils at a number of initial states along with known results for the higher pressure behavior of water-quartz mixtures were combined to construct soil models at various initial soil states. Computations were performed in order to evaluate the sensitivity of rigid plate loading to various facets of constitutive behavior described in the soil models in order to better understand the causes for the newly revealed parametric relationship. The computations closely matched the experimental results, thereby supporting theories regarding the parametric relations. The results from the computations offered insight into the mechanics behind the parametric relations. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Fox, D. M.] US Army, Res Lab, Blast Protect Branch, Aberdeen Proving Ground, MD 21005 USA. [Fox, D. M.] Wayne State Univ, Dept Mech Engn, Detroit, MI 48202 USA. [Akers, S. A.; Windham, J. E.; Ehrgott, J. Q.] US Army, Engn Res & Dev Ctr, Geotech & Struct Lab, Impact & Explos Effects Branch, Vicksburg, MS 39180 USA. [Leiste, U. H.; Fourney, W. L.; Taylor, L. C.] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. [Lee, J. S.] Yonsei Univ, Dept Mech Engn, Seoul 120749, South Korea. RP Lee, JS (reprint author), Yonsei Univ, Dept Mech Engn, Seoul 120749, South Korea. EM joonlee@yonsei.ac.kr FU Ed Fioravante of the US Army Research Laboratory; Scott Schoenfeld; Scott Kukuck; Neil Gniazdowski FX We are grateful to Scott Schoenfeld, Scott Kukuck, Neil Gniazdowski and Ed Fioravante of the US Army Research Laboratory for supporting this work. NR 36 TC 5 Z9 5 U1 0 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X EI 1879-3509 J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD JUL PY 2014 VL 69 BP 182 EP 193 DI 10.1016/j.ijimpeng.2014.02.019 PG 12 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA AH3FY UT WOS:000336010300017 ER PT J AU Coleman, JG Lotufo, GR Kennedy, AJ Poda, AR Rushing, TS Ruiz, CE Bridges, TS AF Coleman, Jessica G. Lotufo, Guilhernie R. Kennedy, Alan J. Poda, Aimee R. Rushing, Todd S. Ruiz, Carlos E. Bridges, Todd S. TI Testing of various membranes for use in a novel sediment porewater isolation chamber for infaunal invertebrate exposure to PCBs SO CHEMOSPHERE LA English DT Article DE Sediment; Porewater; Diffusion; Membrane; Bioavailability; Benthic ID PASSIVE SAMPLER; PORE-WATER AB In benthic sediment bioassays, determining the relative contribution to exposure by contaminants in overlying water, porewater, and sediment particles is technically challenging. The purpose of the present study was to assess the potential for membranes to be utilized as a mechanism to allow freely dissolved hydrophobic organic contaminants into a pathway isolation exposure chamber (PIC) while excluding all sediment particles and dissolved organic carbon (DOC). This investigation was conducted in support of a larger effort to assess contaminant exposure pathways to benthos. While multiple passive samplers exist for estimating concentrations of contaminants in porewater such as those using solid-phase micro extraction (SPME) and polyoxymethylene (POM), techniques to effectively isolate whole organism exposure to porewater within a sediment system are not available. We tested the use of four membranes of different pore sizes (0.1-1.2 mu m) including nylon, polycarbonate, polyethylsulfone, and polytetrafluoroethylene with a hydrophilic coating. Exposures included both diffusion of radiolabeled and non-labeled contaminants across membranes from aqueous, sediment slurry, and whole sediment sources to assess and evaluate the best candidate membrane. Data generated from the present study was utilized to select the most suitable membrane for use in the larger bioavailability project which sought to assess the relevance of functional ecology in bioavailability of contaminated sediments at remediation sites. The polytetrafluoroethylene membrane was selected for use in the PIC, although exclusion of dissolved organic carbon was not achieved. C1 [Coleman, Jessica G.; Lotufo, Guilhernie R.; Kennedy, Alan J.; Poda, Aimee R.; Ruiz, Carlos E.; Bridges, Todd S.] US Army, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Rushing, Todd S.] US Army, Engineer Res & Dev Ctr, Geotech Struct Lab, Vicksburg, MS 39180 USA. RP Coleman, JG (reprint author), US Army, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM jessica.g.coleman@us.army.mil RI Poda, Aimee/K-1905-2012 NR 10 TC 1 Z9 1 U1 3 U2 36 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD JUL PY 2014 VL 106 BP 65 EP 69 DI 10.1016/j.chemosphere.2014.01.062 PG 5 WC Environmental Sciences SC Environmental Sciences & Ecology GA AE6VR UT WOS:000334136600008 PM 24582361 ER PT J AU McAllister, QP Strawhecker, KE Becker, CR Lundgren, CA AF McAllister, Quinn P. Strawhecker, Kenneth E. Becker, Collin R. Lundgren, Cynthia A. TI In situ atomic force microscopy nanoindentation of lithiated silicon nanopillars for lithium ion batteries SO JOURNAL OF POWER SOURCES LA English DT Article DE Lithium ion batteries; Silicon; Nanoindentation; Mechanical properties; AFM; Solid electrolyte interface ID SOLID-ELECTROLYTE INTERPHASE; ANODE MATERIALS; ELASTIC-MODULUS; INDENTATION; NANOWIRES; DELITHIATION; SPECTROSCOPY; TEM AB In this study, atomic force microscopy based nanoindentation techniques are used to measure the in situ mechanical properties of thin film, nanometer sized amorphous-silicon nanopillars (pillar diameters of 1000 nm, 500 nm, and 200 nm) at various stages of lithiation. The pillar indentation modulus and hardness are measured ex situ as-fabricated, in situ during lithiation at two different potentials (or stages of lithiation, 50 mV and 10 mV), and in situ after delithiation at 2 V. The measured modulus of the pristine amorphous silicon nanopillars was 74.7 +/- 12.1 GPa. The hardness of the pristine pillars depended on depth and the contact conditions. In general, the mechanical properties of the nanopillars decreased with increased degrees of lithiation and only partially recovered upon delithiation. The inability of the silicon to recover the as fabricated mechanical properties indicates overall degradation of the pillar during only one lithiation delithiation cycle, which could only be directly measured in situ using the employed atomic force microscopy based technique. Published by Elsevier B.V. C1 [McAllister, Quinn P.; Strawhecker, Kenneth E.] US Army Res Lab, Weap & Mat Res Directorate, Mat & Mfg Sci Div, ATTN RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA. [Becker, Collin R.; Lundgren, Cynthia A.] US Army Res Lab, Sensors & Electron Devices Directorate, Energy & Power Div, ATTN RDRL SED C, Adelphi, MD 20783 USA. RP Becker, CR (reprint author), US Army Res Lab, Electrochem Branch, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM collin.r.becker.civ@mail.mil FU Army Research Laboratory FX The authors are grateful to the Army Research Laboratory for financial support.; The research performed by QPM was supported in part by an appointment to the Postgraduate Research Participant Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARL. NR 39 TC 14 Z9 16 U1 4 U2 144 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 EI 1873-2755 J9 J POWER SOURCES JI J. Power Sources PD JUL 1 PY 2014 VL 257 BP 380 EP 387 DI 10.1016/j.jpowsour.2014.01.077 PG 8 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA AE2CD UT WOS:000333780000049 ER PT J AU Sun, XX Qu, Q Nasrabadi, NM Tran, TD AF Sun, Xiaoxia Qu, Qing Nasrabadi, Nasser M. Tran, Trac D. TI Structured Priors for Sparse-Representation-Based Hyperspectral Image Classification SO IEEE GEOSCIENCE AND REMOTE SENSING LETTERS LA English DT Article DE Classification; hyperspectral image (HSI); sparse representation; structured priors ID RECOGNITION AB Pixelwise classification, where each pixel is assigned to a predefined class, is one of the most important procedures in hyperspectral image (HSI) analysis. By representing a test pixel as a linear combination of a small subset of labeled pixels, a sparse representation classifier (SRC) gives rather plausible results compared with that of traditional classifiers such as the support vector machine. Recently, by incorporating additional structured sparsity priors, the second-generation SRCs have appeared in the literature and are reported to further improve the performance of HSI. These priors are based on exploiting the spatial dependences between the neighboring pixels, the inherent structure of the dictionary, or both. In this letter, we review and compare several structured priors for sparse-representation-based HSI classification. We also propose a new structured prior called the low-rank (LR) group prior, which can be considered as a modification of the LR prior. Furthermore, we will investigate how different structured priors improve the result for the HSI classification. C1 [Sun, Xiaoxia; Qu, Qing; Tran, Trac D.] Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA. [Nasrabadi, Nasser M.] US Army Res Lab, Adelphi, MD 20783 USA. RP Sun, XX (reprint author), Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA. EM xsun9@jhu.edu; qqu2@jhu.edu; nnasraba@arl.army.mil; trac@jhu.edu FU National Science Foundation [CCF-1117545]; Army Research Office [60219-MA]; Office of Naval Research [N000141210765] FX This work was supported in part by the National Science Foundation under Grant CCF-1117545, by the Army Research Office under Grant 60219-MA, and by the Office of Naval Research under Grant N000141210765. NR 21 TC 31 Z9 33 U1 4 U2 29 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1545-598X EI 1558-0571 J9 IEEE GEOSCI REMOTE S JI IEEE Geosci. Remote Sens. Lett. PD JUL PY 2014 VL 11 IS 7 BP 1235 EP 1239 DI 10.1109/LGRS.2013.2290531 PG 5 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA AD2VN UT WOS:000333094000013 ER PT J AU Qu, Q Nasrabadi, NM Tran, TD AF Qu, Qing Nasrabadi, Nasser M. Tran, Trac D. TI Abundance Estimation for Bilinear Mixture Models via Joint Sparse and Low-Rank Representation SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE Abundance estimation; bilinear model; hyperspectral imagery; low-rank representation (LRR); spectral unmixing (SU) ID NONNEGATIVE MATRIX FACTORIZATION; HYPERSPECTRAL DATA; ENDMEMBER EXTRACTION; ALGORITHM; IMAGERY AB Sparsity-based unmixing algorithms, exploiting the sparseness property of the abundances, have recently been proposed with promising performances. However, these algorithms are developed for the linear mixture model (LMM), which cannot effectively handle the nonlinear effects. In this paper, we extend the current sparse regression methods for the LMM to bilinear mixture models (BMMs), where the BMMs introduce additional bilinear terms in the LMM in order to model second-order photon scattering effects. To solve the abundance estimation problem for the BMMs, we propose to perform a sparsity-based abundance estimation by using two dictionaries: a linear dictionary containing all the pure endmembers and a bilinear dictionary consisting of all the possible second-order endmember interaction components. Then, the abundance values can be estimated from the sparse codes associated with the linear dictionary. Moreover, to exploit the spatial data structure where the adjacent pixels are usually homogeneous and are often mixtures of the same materials, we first employ the joint-sparsity (row-sparsity) model to enforce structured sparsity on the abundance coefficients. However, the joint-sparsity model is often a strict assumption, which might cause some aliasing artifacts for the pixels that lie on the boundaries of different materials. To deal with this problem, the low-rank-representation model, which seeks the lowest rank representation of the data, is further introduced to better capture the spatial data structure. Our simulation results demonstrate that the proposed algorithms provide much enhanced performance compared with state-of-the-art algorithms. C1 [Qu, Qing; Tran, Trac D.] Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA. [Nasrabadi, Nasser M.] US Army, Res Lab, Adelphi, MD 20783 USA. RP Qu, Q (reprint author), Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA. EM qqu2@jhu.edu; nnasraba@arl.army.mil; trac@jhu.edu FU National Science Foundation [CCF-1117545]; Army Research Office [60219-MA]; Office of Naval Research [N00014-12-1-0765] FX This work was supported in part by the National Science Foundation under Grant CCF-1117545, by the Army Research Office under Grant 60219-MA, and by Office of Naval Research under Grant N00014-12-1-0765. NR 59 TC 19 Z9 20 U1 2 U2 19 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0196-2892 EI 1558-0644 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD JUL PY 2014 VL 52 IS 7 BP 4404 EP 4423 DI 10.1109/TGRS.2013.2281981 PG 20 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA AC5YO UT WOS:000332597100056 ER PT J AU Convertino, VA AF Convertino, Victor A. TI Neurohumoral mechanisms associated with orthostasis: reaffirmation of the significant contribution of the heart rate response SO FRONTIERS IN PHYSIOLOGY LA English DT Review DE orthostatic tolerance; blood pressure regulation; lower body negative pressure; parasympathetic activity; sympathetic activity; propranolol; atropine ID BODY NEGATIVE-PRESSURE; CARDIAC NORADRENALINE SPILLOVER; AUTONOMIC FUNCTIONS; VAGAL BAROREFLEX; TOLERANCE; HUMANS; INTOLERANCE; STRESS; SPACEFLIGHT; HYPOTENSION AB The inability to compensate for acute central hypovolemia underlies the clinical development of orthostatic hypotension and instability (e.g., syncope). Although neuro-humoral control of both cardiac output and peripheral vascular resistance contributes to hemodynamic stability during orthostasis, a notion has been proposed that the failure of adequate peripheral vascular constriction rather than cardiac responses represents the primary mechanism underlying the development of orthostatic intolerance. This review article provides an opportunity to present compelling evidence captured over the past 30 years in our laboratory to support the concept that neural-mediated tachycardia during orthostasis in healthy individuals represents a critical response to tolerating acute reduction in central blood volume in addition to, and independent of, peripheral vascular constriction. In this review paper, data are presented from experiments using graded lower body negative pressure (LBNP) as a method to induce orthostatic intolerance in two experimental human models: (1) comparison of heart rate and autonomic responses in individuals with relatively high and low tolerance to LBNP; and (2) vagal and sympathetic blockade of cardiac neural control. These experiments revealed that: (1) greater elevations in heart rate are associated with higher orthostatic (LBNP) tolerance; (2) higher orthostatic heart rate is associated with greater sympathetic nerve activity and withdrawal of vagally-mediated cardiac baroreflex response; and (3) non-specific sympathetic blockade causes a pronounced reduction in heart rate and LBNP tolerance. Cardiac parasympathetic withdrawal contributes to protection against development of hypotension during the initial seconds of transition to an orthostatic challenge, while the primary mechanism by which tachycardia defends orthostatic stability in healthy subjects for extended durations is mediated predominantly through sympathetic adrenergic control. C1 [Convertino, Victor A.] US Army, Inst Surg Res, Div Res, JBSA Ft Sam Houston, TX 78234 USA. RP Convertino, VA (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass, JBSA Ft Sam Houston, TX 78234 USA. EM victor.a.convertino.civ@mail.mil NR 38 TC 9 Z9 9 U1 0 U2 7 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1664-042X J9 FRONT PHYSIOL JI Front. Physiol. PD JUN 30 PY 2014 VL 5 AR 236 DI 10.3389/fphys.2014.00236 PG 8 WC Physiology SC Physiology GA AX6YZ UT WOS:000347065200001 PM 25071585 ER PT J AU Hinojosa-Laborde, C Ryan, KL Rickards, CA Convertino, VA AF Hinojosa-Laborde, Carmen Ryan, Kathy L. Rickards, Caroline A. Convertino, Victor A. TI Resting sympathetic baroreflex sensitivity in subjects with low and high tolerance to central hypovolemia induced by lower body negative pressure SO FRONTIERS IN PHYSIOLOGY LA English DT Article DE hemorrhage; orthostatic intolerance; autonomic reflex ID CAROTID-CARDIAC BAROREFLEX; ORTHOSTATIC HYPOTENSION; NERVE ACTIVITY; VASOCONSTRICTOR RESPONSES; VAGAL BAROREFLEX; HUMANS; HEALTHY; INTOLERANCE; MODULATION; EXERCISE AB Central hypovolemia elicited by orthostasis or hemorrhage triggers sympathetically-mediated baroreflex responses to maintain organ perfusion; these reflexes are less sensitive in patients with orthostatic intolerance, and during conditions of severe blood loss, may result in cardiovascular collapse (decompensatory or circulatory shock). The ability to tolerate central hypovolemia is variable and physiological factors contributing to tolerance are emerging. We tested the hypothesis that resting muscle sympathetic nerve activity (MSNA) and sympathetic baroreflex sensitivity (BRS) are attenuated in male and female subjects who have low tolerance (LT) to central hypovolemia induced by lower body negative pressure (LBNP). MSNA and diastolic arterial pressure (DAP) were recorded in 47 human subjects who subsequently underwent LBNP to tolerance (onset of presyncopal symptoms). LT subjects experienced presyncopal symptoms prior to completing LBNP of 60 mm Hg, and subjects with high tolerance (HT) experienced presyncopal symptoms after completing LBNP of 60 mm Hg. Contrary to our hypothesis, resting MSNA burst incidence was not different between LT and HT subjects, and was not related to time to presyncope. BRS was assessed as the slope of the relationship between spontaneous fluctuations in DAP and MSNA during 5 min of supine rest. MSNA burst incidence/DAP correlations were greater than or equal to 0.5 in 37 subjects (LT n = 9; Hi n = 28), and BRS was not different between LT and HT (-1.8+/-0.3 vs. 2.2+/-0.2 bursts.(100 beats)(-1).mm Hg-1, p = 0.29). We conclude that tolerance to central hypovolemia is not related to either resting MSNA or sympathetic BRS. C1 [Hinojosa-Laborde, Carmen; Ryan, Kathy L.; Convertino, Victor A.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Rickards, Caroline A.] Univ N Texas, Ctr Hlth Sci, Ft Worth, TX USA. RP Hinojosa-Laborde, C (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass, JBSA Ft Sam Houston, TX 78234 USA. EM carmen.hinojosa-laborde.civ@mail.mil FU United States Army Medical Research and Materiel Command FX We thank the research volunteers for their cheerful participation, and Mr. Gary Muniz for his excellent laboratory assistance. This study was funded by the United States Army Medical Research and Materiel Command. NR 36 TC 2 Z9 2 U1 0 U2 3 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1664-042X J9 FRONT PHYSIOL JI Front. Physiol. PD JUN 30 PY 2014 VL 5 AR 241 DI 10.3389/fphys.2014.00241 PG 6 WC Physiology SC Physiology GA AX6ZB UT WOS:000347065400001 PM 25071587 ER PT J AU Rokni, MR Widener, CA Nardi, AT Champagne, VK AF Rokni, M. R. Widener, C. A. Nardi, A. T. Champagne, V. K. TI Nano crystalline high energy milled 5083 Al powder deposited using cold spray SO APPLIED SURFACE SCIENCE LA English DT Article DE Cold spray; Nanocrystalline materials; Electron microscopy; Nanoindentation ID ULTRAFINE-GRAINED ALUMINUM; MECHANICAL-PROPERTIES; MG ALLOY; NANOCRYSTALLINE MATERIALS; DEFORMATION; COATINGS; MICROSTRUCTURE; STRENGTH; COPPER; EVOLUTION AB Electron microscopy and nanoindentation are used to investigate the relationship between microstructure and nanohardness of a non-cryomilled, nanocrystalline 5083 Al alloy powder before and after being deposited by cold spray. Microstructural investigations observed the presence of nano grains in the powder microstructure, ranging from 20 to 80 nm and with a typical grain size of 40-50 nm. It was also revealed that the nanocrystalline structure of the powder is retained after cold spraying. As a result, almost no change in nanohardness was indicated between the powder and the particles interior in the cold sprayed layer. However, hardness was substantially higher in some regions in the cold sprayed layer, which was attributed to the particle-particle interfaces or other areas with very small nano grain size. The presence of some un-joined particle remnant lines was also found in the deposition and explained through Critical Velocity Ratio (CVR) of powder particles. Although cold spray is a high deformation process, there is little evidence of dislocations within the nanograins of the cold sprayed layer. The latter observation is rationalized through intragranular dislocation slip and recovery mechanisms. (C) 2014 Elsevier B.V. All rights reserved. C1 [Rokni, M. R.; Widener, C. A.] SDSM&T, Adv Mat Proc Ctr, Dept Mat & Met Engn, Rapid City, SD USA. [Nardi, A. T.] United Technol Res Ctr, East Hartford, CT USA. [Champagne, V. K.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD USA. RP Rokni, MR (reprint author), SDSM&T, Adv Mat Proc Ctr, Dept Mat & Met Engn, Rapid City, SD USA. EM mohammadreza.rokni@mines.sdsmt.edu NR 49 TC 6 Z9 6 U1 2 U2 26 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-4332 EI 1873-5584 J9 APPL SURF SCI JI Appl. Surf. Sci. PD JUN 30 PY 2014 VL 305 BP 797 EP 804 DI 10.1016/j.apsusc.2014.03.010 PG 8 WC Chemistry, Physical; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter SC Chemistry; Materials Science; Physics GA AI0GY UT WOS:000336525400111 ER PT J AU Polashenski, C Courville, Z Benson, C Wagner, A Chen, J Wong, G Hawley, R Hall, D AF Polashenski, Chris Courville, Zoe Benson, Carl Wagner, Anna Chen, Justin Wong, Gifford Hawley, Robert Hall, Dorothy TI Observations of pronounced Greenland ice sheet firn warming and implications for runoff production SO GEOPHYSICAL RESEARCH LETTERS LA English DT Article ID SEA-LEVEL RISE; MELT EXTENT; MODIS; ACCUMULATION; VARIABILITY AB Field measurements of shallow borehole temperatures in firn across the northern Greenland ice sheet are collected during May 2013. Sites first measured in 1952-1955 are revisited, showing long-term trends in firn temperature. Results indicate a pattern of substantial firn warming (up to +5.7 degrees C) at midlevel elevations (1400-2500 m) and little temperature change at high elevations (>2500 m). We find that latent heat transport into the firn due to meltwater percolation drives the observed warming. Modeling shows that heat is stored at depth for several years, and energy delivered from consecutive melt events accumulates in the firn. The observed warming is likely not yet in equilibrium with recent melt production rates but captures the progression of sites in the percolation facies toward net runoff production. C1 [Polashenski, Chris; Wagner, Anna] US Army Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. [Polashenski, Chris; Courville, Zoe] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. [Courville, Zoe] US Army Cold Reg Res & Engn Lab, Hanover, NH USA. [Benson, Carl] Univ Alaska Fairbanks, Inst Geophys, Fairbanks, AK 99775 USA. [Chen, Justin] Hanover High Sch, Hanover, NH USA. [Wong, Gifford; Hawley, Robert] Dartmouth Coll, Dept Earth Sci, Hanover, NH 03755 USA. [Hall, Dorothy] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. RP Polashenski, C (reprint author), US Army Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. EM chris.polashenski@gmail.com FU National Science Foundation Division of Polar Programs, the NSF award [1204145] FX We would like to acknowledge the support provided by the National Science Foundation Division of Polar Programs, the NSF award 1204145, the able and cheerful assistance of Michael Stewart, Nathan Stewart, and Thomas Overly in the collection of temperature data, and the logistics provided by CH2MHill Polar Field Services and Stanford Research Institute teams. We thank Koni Steffen for sharing up to date GC-Net Data used to extend relevant analyses. All data used in this publication can be accessed in the National Snow and Ice Data Center Advanced Cooperative Arctic Data and Information Service website: nsidc.org/acadis. The authors thank two anonymous reviewers for their helpful comments in improving this paper. NR 48 TC 6 Z9 6 U1 4 U2 19 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0094-8276 EI 1944-8007 J9 GEOPHYS RES LETT JI Geophys. Res. Lett. PD JUN 28 PY 2014 VL 41 IS 12 BP 4238 EP 4246 DI 10.1002/2014GL059806 PG 9 WC Geosciences, Multidisciplinary SC Geology GA AN0SM UT WOS:000340294300018 ER PT J AU Jae, LT Raaben, M Herbert, AS Kuehne, AI Wirchnianski, AS Soh, TK Stubbs, SH Janssen, H Damme, M Saftig, P Whelan, SP Dye, JM Brummelkamp, TR AF Jae, Lucas T. Raaben, Matthijs Herbert, Andrew S. Kuehne, Ana I. Wirchnianski, Ariel S. Soh, Timothy K. Stubbs, Sarah H. Janssen, Hans Damme, Markus Saftig, Paul Whelan, Sean P. Dye, John M. Brummelkamp, Thijn R. TI Lassa virus entry requires a trigger-induced receptor switch SO SCIENCE LA English DT Article ID LYMPHOCYTIC CHORIOMENINGITIS VIRUS; ALPHA-DYSTROGLYCAN; HUMAN AIRWAY; MEMBRANE; BINDING; SPECIFICITY; INHIBITORS; COMPLEX; FEVER; CELLS AB Lassa virus spreads from a rodent to humans and can lead to lethal hemorrhagic fever. Despite its broad tropism, chicken cells were reported 30 years ago to resist infection. We found that Lassa virus readily engaged its cell-surface receptor a-dystroglycan in avian cells, but virus entry in susceptible species involved a pH-dependent switch to an intracellular receptor, the lysosome-resident protein LAMP1. Iterative haploid screens revealed that the sialyltransferase ST3GAL4 was required for the interaction of the virus glycoprotein with LAMP1. A single glycosylated residue in LAMP1, present in susceptible species but absent in birds, was essential for interaction with the Lassa virus envelope protein and subsequent infection. The resistance of Lamp1-deficient mice to Lassa virus highlights the relevance of this receptor switch in vivo. C1 [Jae, Lucas T.; Raaben, Matthijs; Janssen, Hans; Brummelkamp, Thijn R.] Netherlands Canc Inst, NL-1066 CX Amsterdam, Netherlands. [Raaben, Matthijs; Soh, Timothy K.; Stubbs, Sarah H.; Whelan, Sean P.] Harvard Univ, Sch Med, Dept Microbiol & Immunobiol, Boston, MA 02115 USA. [Herbert, Andrew S.; Kuehne, Ana I.; Wirchnianski, Ariel S.; Dye, John M.] US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Damme, Markus; Saftig, Paul] Univ Kiel, Inst Biochem, D-24118 Kiel, Germany. [Brummelkamp, Thijn R.] Austrian Acad Sci, CeMM Res Ctr Mol Med, A-1090 Vienna, Austria. [Brummelkamp, Thijn R.] Cancer Genom Ctr CGC Nl, NL-1066 CX Amsterdam, Netherlands. RP Brummelkamp, TR (reprint author), Netherlands Canc Inst, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands. EM sean_whelan@hms.harvard.edu; john.m.dye1.civ@mail.mil; t.brummelkamp@nki.nl RI Saftig, Paul/A-7966-2010 FU CGC.nl; Nederlandse Organisatie voor Wetenschappelijk Onderzoek Vidi grant [91711316]; European Research Council (ERC) Starting Grant [ERC-2012-StG 309634]; Deutsche Forschungsgemeinschaft [DFG SPP1580, GRK1459]; NIH [AI081842, AI109740]; Defense Threat Reduction Agency [CB3947] FX We thank T. Sixma, A. Perrakis, E. von Castelmur, D. Lefeber, and members of the Brummelkamp group for discussion; M. Rusch for mouse breeding; S. Kunz for a plasmid encoding Lassa-GP; E. Ollmann-Saphire for an Fc-fusion vector; R. Schoepp for GP1 antibodies; and M. Verheije for DF1 cells. This work was supported by CGC.nl, Nederlandse Organisatie voor Wetenschappelijk Onderzoek Vidi grant 91711316, and European Research Council (ERC) Starting Grant (ERC-2012-StG 309634) to T. R. B.; Deutsche Forschungsgemeinschaft (DFG SPP1580 and GRK1459) to P. S.; and NIH grants AI081842 and AI109740 to S. P. W. J.M.D was supported by the Defense Threat Reduction Agency (CB3947). The HAP1 cells that were used are distributed under a materials transfer agreement. Opinions, interpretations, conclusions, and recommendations are those of the author and are not necessarily endorsed by the U.S. Army. T. R. B. is a cofounder and shareholder of Haplogen GmbH, a company involved in haploid genetics. Sequencing data are accessible at www.ncbi.nlm.nih.gov/sra (accession SRP041566). NR 23 TC 41 Z9 43 U1 7 U2 35 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 0036-8075 EI 1095-9203 J9 SCIENCE JI Science PD JUN 27 PY 2014 VL 344 IS 6191 BP 1506 EP 1510 DI 10.1126/science.1252480 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AJ7PZ UT WOS:000337889900048 PM 24970085 ER PT J AU McCormack, R Apostle, K Boyer, D Moola, F Perey, B Stone, T Viskontas, D Lemke, HM Zomar, M Moon, K Moon, R Oatt, A Buckley, RE Duffy, P Korley, R Puloski, S Johnston, K Powell, J Carcary, K Sanders, D Lawendy, A Tieszer, C Stephen, D Kreder, H Jenkinson, R Nousiainen, M Axelrod, T Murnaghan, J Nam, D Wadey, V Yee, A Milner, K Kunz, M Schemitsch, EH Ahn, H Hall, JA McKee, MD Whelan, DB Nauth, A Vicente, MR Wild, LM Khan, RM Hidy, JT Coles, C Leighton, R Biddulph, M Johnston, D Glazebrook, M Alexander, D Coady, C Dunbar, M Amirault, D Gross, M Oxner, W Reardon, G Richardson, G Trenholm, A Wong, I Trask, K MacDonald, S Dobbin, G Bicknell, R Yach, J Bardana, D Wood, G Harrison, M Yen, D Lambert, S Howells, F Ward, A Zalzal, P Brien, H Naumetz, V Weening, B Simunovic, N Wai, EK Papp, S Gofton, WT Liew, A Kingwell, SP Johnson, G O'Neil, J Roffey, DM Borsella, V Avram, V Oliver, TM Jones, V Jones, CB Ringler, JR Endres, TJ Sietsema, DL Jeray, KJ Broderick, JS Goetz, DR Pace, TB Schaller, TM Porter, SE Tanner, SL Snider, RG Nastoff, LA Bielby, SA Switzer, JA Cole, PA Anderson, SA Lafferty, PM Li, MN Ly, TV Marston, SB Foley, AL Vang, S Wright, DM Marcantonio, AJ Kain, MSH Iorio, R Specht, LM Tilzey, JF Lobo, MJ Garfi, JS Vallier, HA Dolenc, A Robinson, C Prayson, MJ Laughlin, R Rubino, LJ May, J Rieser, GR Dulaney-Cripe, L Gayton, C Shaer, J Schrickel, T Hileman, B Gorczyca, JT Gross, JM Humphrey, CA Kates, S Noble, K McIntyre, AW Pecorella, K Davis, CA Weinerman, S Weingarten, P Stull, P Lindenbaum, S Hewitt, M Schwappach, J Baker, JK Rutherford, T Newman, H Lieberman, S Finn, E Robbins, K Hurley, M Lyle, L Mitchell, K Browner, K Whatley, E Payton, K Reeves, C Cannada, LK Karges, D Hill, L Mehta, S Esterhai, J Ahn, J Horan, AD McGinnis, K Kaminski, CA Kowalski, BN Keeve, JP Anderson, CG McDonald, MD Hoffman, JM Tarkin, I Siska, P Gruen, G Evans, A Farrell, DJ Irrgang, J Luther, A Cross, WW Cass, JR Sems, SA Torchia, ME Scrabeck, T Jenkins, M Dumais, J Romero, AW Sagebien, CA Butler, MS Monica, JT Seuffert, P Hsu, JR Ficke, J Charlton, M Napierala, M Fan, M Tornetta, P Tannoury, C Carlisle, H Silva, H Archdeacon, M Finnan, R Le, T Wyrick, J Hess, S Brennan, ML Probe, R Kile, E Mills, K Clipper, L Yu, M Erwin, K Horwitz, D Strohecker, K Swenson, TK Aurang, K Zohman, G Peterson, B Huff, RB Baele, J Weber, T Edison, M McBeth, J Shively, K Ertl, JP Mullis, B Parr, JA Worman, R Frizzell, V Moore, MM Tobias, E Thomas, E DePaolo, CJ Alosky, R Shell, LE Hampton, L Shepard, S Nanney, T Cuento, C Cantu, RV Henderson, ER Eickhoff, LS Hammerberg, EM Stahel, P Hak, D Mauffrey, C Gibula, D Gissel, H Henderson, C Zamorano, DP Tynan, MC Pourmand, D Lawson, D Della Rocca, GJ Crist, BD Murtha, YM Anderson, LK Linehan, C Pilling, L Lewis, CG Caminiti, S Sullivan, RJ Roper, E Obremskey, W Kregor, P Richards, JE Stringfellow, K Dohm, MP Zellar, A Segers, MJM Zijl, JAC Verhoeven, B Smits, AB de Vries, JPPM Fioole, B van der Hoeven, H Theunissen, EBM Reilingh, TSD Govaert, L Wittich, P de Brauw, M Wille, J Go, PMNYM Ritchie, ED Wessel, RN Hammacher, ER Heetveld, MJ Visser, GA Stockmann, H Silvis, R Snellen, JP Rijbroek, B Scheepers, JJG Vermeulen, EGJ Siroen, MPC Vuylsteke, R Brom, HLF Rijna, H de Rijcke, PAR Koppert, CL Buijk, SE Groenendijk, RPR Dawson, I Tetteroo, GWM Bruijninckx, MMM Doornebosch, PG de Graaf, EJR van der Elst, M van der Pol, CC van 't Riet, M Karsten, TM de Vries, MR Stassen, LPS Schep, NWL Ben Schmidt, G Hoffman, WH Poolman, RW Simons, MP van der Heijden, FHWM Willems, WJ de Meulemeester, FRAJ van der Hart, CP Turckan, K Festen, S de Nies, F Haverlag, R Out, NJM Bosma, J van Kampen, A Biert, J van Vugt, AB Edwards, MJR Blokhuis, TJ Frolke, JPM Geeraedts, LMG Gardeniers, JWM Tan, ETCH Poelhekke, LMSJ Malefijt, MCD Schreurs, B Roukema, GR Josaputra, HA Keller, P de Rooij, PD Kuiken, H Boxma, H Cleffken, BI Liem, R Rhemrev, SJ Bosman, CHR van Otterloo, AD Hoogendoorn, J de Vries, AC Meylaerts, SAG Verhofstad, MHJ Meijer, J van Egmond, T van der Heijden, FHWM van der Brand, I Patka, P Eversdijk, MG Peters, R Den Hartog, D Van Waes, OJF Oprel, P van der Vis, HM Campo, M Verhagen, R Albers, GHR Zurcher, AW Simmermacher, RKJ van Mulken, J van Wessem, K Blokhuis, TJ van Gaalen, SM Leenen, LPH Bronkhorst, MWGA Guicherit, OR Goslings, JC Haverlag, R Ponsen, KJ Bhatia, M Arora, V Tyagi, V Liew, S Bedi, H Carr, A Curry, H Chia, A Csongvay, S Donohue, C Doig, S Edwards, E Etherington, G Esser, M Gong, A Jain, A Li, D Miller, R Moaveni, A Russ, M Ton, L Wang, O Dowrick, A Murdoch, Z Sage, C Frihagen, F Clarke-Jenssen, J Hjorthaug, G Ianssen, T Amundsen, A Brattgjerd, JE Borch, T Boe, B Flatoy, B Hasselund, S Haug, KJ Hemlock, K Hoseth, TM Jomaas, G Kibsgard, T Lona, T Moatshe, G Muller, O Molund, M Nicolaisen, T Nilsen, F Rydinge, J Smedsrud, M Stodle, A Trommer, A Ugland, S Karlsten, A Ekas, G Vesterhus, EB Brekke, AC Gupta, A Jain, N Khan, F Sharma, A Sanghavi, A Trivedi, M Rai, A Subash Rai, K Yadav, V Singh, S Rai, K Tetsworth, K Donald, G Weinrauch, P Pincus, P Yang, S Halliday, B Gervais, T Holt, M Flynn, A Prasad, AS Mishra, V Sundaresh, DC Khanna, A Cherian, JJ Olakkengil, DJ Sharma, G Pirpiris, M Love, D Bucknill, A Farrugia, RJ Pape, HC Knobe, M Pfeifer, R Hull, P Lewis, S Evans, S Nanda, R Logishetty, R Anand, S Bowler, C Dadi, A Palla, N Ganguly, U Rai, BS Rajakumar, J Jennings, A Chuter, G Rose, G Horner, G Clark, C Eke, K Reed, M Herriott, C Dobb, C Bhandari, M Swiontkowski, M Devereaux, P Schemitsch, EH Heetveld, MJ Jeray, K Liew, S Thabane, L Walter, S Sprague, S Scott, T Guyatt, G Bhandari, M Swiontkowski, M Devereaux, P Guyatt, G Heetveld, MJ Jeray, K Liew, S Schemitsch, EH Thabane, L Walter, S Bhandari, M Sprague, S Viveiros, H McKay, P Scott, T Swinton, M Truong, V Koo, K Heels-Ansdell, D Zhou, Q Buckingham, L Duraikannan, A Maddock, D Simunovic, N Swiontkowski, M Agel, J Heetveld, MJ Van Lieshout, EMM Zielinski, SM Rangan, A Hanusch, BC Kottam, L Clarkson, R Della Rocca, GJ Haverlag, R Liew, S Slobogean, G Katz, J Gillespie, B Greendale, GA Guy, P Hartman, C Rubin, C Waddell, J AF McCormack, Robert Apostle, Kelly Boyer, Dory Moola, Farhad Perey, Bertrand Stone, Trevor Viskontas, Darius Lemke, H. Michael Zomar, Mauri Moon, Karyn Moon, Raely Oatt, Amber Buckley, Richard E. Duffy, Paul Korley, Robert Puloski, Shannon Johnston, Kelly Powell, James Carcary, Kimberly Sanders, David Lawendy, Abdel Tieszer, Christina Stephen, David Kreder, Hans Jenkinson, Richard Nousiainen, Markku Axelrod, Terry Murnaghan, John Nam, Diane Wadey, Veronica Yee, Albert Milner, Katrine Kunz, Monica Schemitsch, Emil H. Ahn, Henry Hall, Jeremy A. McKee, Michael D. Whelan, Daniel B. Nauth, Aaron Vicente, Milena R. Wild, Lisa M. Khan, Ryan M. Hidy, Jennifer T. Coles, Chad Leighton, Ross Biddulph, Michael Johnston, David Glazebrook, Mark Alexander, David Coady, Cathy Dunbar, Michael Amirault, David Gross, Michael Oxner, William Reardon, Gerald Richardson, Glen Trenholm, Andrew Wong, Ivan Trask, Kelly MacDonald, Shelley Dobbin, Gwen Bicknell, Ryan Yach, Jeff Bardana, Davide Wood, Gavin Harrison, Mark Yen, David Lambert, Sue Howells, Fiona Ward, Angela Zalzal, Paul Brien, Heather Naumetz, V. Weening, Brad Simunovic, Nicole Wai, Eugene K. Papp, Steve Gofton, Wade T. Liew, Allen Kingwell, Stephen P. Johnson, Garth O'Neil, Joseph Roffey, Darren M. Borsella, Vivian Avram, Victoria Oliver, Todd M. Jones, Vicki Jones, Clifford B. Ringler, James R. Endres, Terrence J. Sietsema, Debra L. Jeray, Kyle J. Broderick, J. Scott Goetz, David R. Pace, Thomas B. Schaller, Thomas M. Porter, Scott E. Tanner, Stephanie L. Snider, Rebecca G. Nastoff, Lauren A. Bielby, Shea A. Switzer, Julie A. Cole, Peter A. Anderson, Sarah A. Lafferty, Paul M. Li, Mengnai Ly, Thuan V. Marston, Scott B. Foley, Amy L. Vang, Sandy Wright, David M. Marcantonio, Andrew J. Kain, Michael S. H. Iorio, Richard Specht, Lawrence M. Tilzey, John F. Lobo, Margaret J. Garfi, John S. Vallier, Heather A. Dolenc, Andrea Robinson, Chalitha Prayson, Michael J. Laughlin, Richard Rubino, L. Joseph May, Jedediah Rieser, Geoffrey Ryan Dulaney-Cripe, Liz Gayton, Chris Shaer, James Schrickel, Tyson Hileman, Barbara Gorczyca, John T. Gross, Jonathan M. Humphrey, Catherine A. Kates, Stephen Noble, Krista McIntyre, Allison W. Pecorella, Kaili Davis, Craig A. Weinerman, Stewart Weingarten, Peter Stull, Philip Lindenbaum, Stephen Hewitt, Michael Schwappach, John Baker, Janell K. Rutherford, Tori Newman, Heike Lieberman, Shane Finn, Erin Robbins, Kristin Hurley, Meghan Lyle, Lindsey Mitchell, Khalis Browner, Kieran Whatley, Erica Payton, Krystal Reeves, Christina Cannada, Lisa K. Karges, David Hill, Leslie Mehta, Samir Esterhai, John Ahn, Jaimo Horan, Annamarie D. McGinnis, Kelly Kaminski, Christine A. Kowalski, Brynn N. Keeve, Jonathan P. Anderson, Christopher G. McDonald, Michael D. Hoffman, Jodi M. Tarkin, Ivan Siska, Peter Gruen, Gary Evans, Andrew Farrell, Dana J. Irrgang, James Luther, Arlene Cross, William W., III Cass, Joseph R. Sems, Stephen A. Torchia, Michael E. Scrabeck, Tyson Jenkins, Mark Dumais, Jules Romero, Amanda W. Sagebien, Carlos A. Butler, Mark S. Monica, James T. Seuffert, Patricia Hsu, Joseph R. Ficke, James Charlton, Michael Napierala, Matthew Fan, Mary Tornetta, Paul, III Tannoury, Chadi Carlisle, Hope Silva, Heather Archdeacon, Michael Finnan, Ryan Le, Toan Wyrick, John Hess, Shelley Brennan, Michael L. Probe, Robert Kile, Evelyn Mills, Kelli Clipper, Lydia Yu, Michelle Erwin, Katie Horwitz, Daniel Strohecker, Kent Swenson, Teresa K. Aurang, Kamran Zohman, Gary Peterson, Brett Huff, Roger B. Baele, Joseph Weber, Timothy Edison, Matt McBeth, Jessica Shively, Karl Ertl, Janos P. Mullis, Brian Parr, J. Andrew Worman, Ripley Frizzell, Valda Moore, Molly M. Tobias, Erin Thomas, Emily DePaolo, Charles J. Alosky, Rachel Shell, Leslie E. Hampton, Lynne Shepard, Stephanie Nanney, Tracy Cuento, Claudine Cantu, Robert V. Henderson, Eric R. Eickhoff, Linda S. Hammerberg, E. Mark Stahel, Philip Hak, David Mauffrey, Cyril Gibula, Douglas Gissel, Hannah Henderson, Corey Zamorano, David P. Tynan, Martin C. Pourmand, Deeba Lawson, Deanna Della Rocca, Gregory J. Crist, Brett D. Murtha, Yvonne M. Anderson, Linda K. Linehan, Colleen Pilling, Lindsey Lewis, Courtland G. Caminiti, Stephanie Sullivan, Raymond J. Roper, Elizabeth Obremskey, William Kregor, Philip Richards, Justin E. Stringfellow, Kenya Dohm, Michael P. Zellar, Abby Segers, Michiel J. M. Zijl, Jacco A. C. Verhoeven, Bart Smits, Anke B. de Vries, Jean Paul P. M. Fioole, Bram van der Hoeven, Henk Theunissen, Evert B. M. Reilingh, Tammo S. de Vries Govaert, Lonneke Wittich, Philippe de Brauw, Maurits Wille, Jan Go, Peter M. N. Y. M. Ritchie, Ewan D. Wessel, Ronald N. Hammacher, Eric R. Heetveld, Martin J. Visser, Gijs A. Stockmann, Heyn Silvis, Rob Snellen, Jaap P. Rijbroek, Bram Scheepers, Joris J. G. Vermeulen, Erik G. J. Siroen, Michiel P. C. Vuylsteke, Ronald Brom, Hans L. F. Rijna, Herman de Rijcke, Piet A. R. Koppert, Cees L. Buijk, Steven E. Groenendijk, Richard P. R. Dawson, Imro Tetteroo, Geert W. M. Bruijninckx, Milko M. M. Doornebosch, Pascal G. de Graaf, Eelco J. R. van der Elst, Maarten van der Pol, Carmen C. van 't Riet, Martijne Karsten, Tom M. de Vries, Mark R. Stassen, Laurents P. S. Schep, Niels W. L. Ben Schmidt, G. Hoffman, W. H. Poolman, Rudolf W. Simons, Maarten P. van der Heijden, Frank H. W. M. Willems, W. Jaap de Meulemeester, Frank R. A. J. van der Hart, Cor P. Turckan, Kahn Festen, Sebastiaan de Nies, Frank Haverlag, Robert Out, Nico J. M. Bosma, Jan van Kampen, Albert Biert, Jan van Vugt, Arie B. Edwards, Michael J. R. Blokhuis, Taco J. Frolke, Jan Paul M. Geeraedts, Leo M. G. Gardeniers, Jean W. M. Tan, Edward T. C. H. Poelhekke, Lodewijk M. S. J. Malefijt, Maarten C. de Waal Schreurs, Bart Roukema, Gert R. Josaputra, Hong A. Keller, Paul de Rooij, Peter D. Kuiken, Hans Boxma, Han Cleffken, Berry I. Liem, Ronald Rhemrev, Steven J. Bosman, Coks H. R. van Otterloo, Alexander de Mol Hoogendoorn, Jochem de Vries, Alexander C. Meylaerts, Sven A. G. Verhofstad, Michiel H. J. Meijer, Joost van Egmond, Teun van der Heijden, Frank H. W. M. van der Brand, Igor Patka, Peter Eversdijk, Martin G. Peters, Rolf Den Hartog, Dennis Van Waes, Oscar J. F. Oprel, Pim van der Vis, Harm M. Campo, Martin Verhagen, Ronald Albers, G. H. Robert Zurcher, Arthur W. Simmermacher, Rogier K. J. van Mulken, Jeroen van Wessem, Karlijn Blokhuis, Taco J. van Gaalen, Steven M. Leenen, Luke P. H. Bronkhorst, Maarten W. G. A. Guicherit, Onno R. Goslings, J. Carel Haverlag, Robert Ponsen, Kees Jan Bhatia, Mahesh Arora, Vinod Tyagi, Vivek Liew, Susan Bedi, Harvinder Carr, Ashley Curry, Hamish Chia, Andrew Csongvay, Steve Donohue, Craig Doig, Stephen Edwards, Elton Etherington, Greg Esser, Max Gong, Andrew Jain, Arvind Li, Doug Miller, Russell Moaveni, Ash Russ, Matthias Ton, Lu Wang, Otis Dowrick, Adam Murdoch, Zoe Sage, Claire Frihagen, Frede Clarke-Jenssen, John Hjorthaug, Geir Ianssen, Torben Amundsen, Asgeir Brattgjerd, Jan Egil Borch, Tor Boe, Berthe Flatoy, Bernhard Hasselund, Sondre Haug, Knut Jorgen Hemlock, Kim Hoseth, Tor Magne Jomaas, Geir Kibsgard, Thomas Lona, Tarjei Moatshe, Gilbert Muller, Oliver Molund, Marius Nicolaisen, Tor Nilsen, Fredrik Rydinge, Jonas Smedsrud, Morten Stodle, Are Trommer, Axel Ugland, Stein Karlsten, Anders Ekas, Guri Vesterhus, Elise Berg Brekke, Anne Christine Gupta, Ajay Jain, Neeraj Khan, Farah Sharma, Ateet Sanghavi, Amir Trivedi, Mittal Rai, Anil Subash Rai, Kamal Yadav, Vineet Singh, Sanjay Rai, Kamal Tetsworth, Kevin Donald, Geoff Weinrauch, Patrick Pincus, Paul Yang, Steven Halliday, Brett Gervais, Trevor Holt, Michael Flynn, Annette Prasad, Amal Shankar Mishra, Vimlesh Sundaresh, D. C. Khanna, Angshuman Cherian, Joe Joseph Olakkengil, Davy J. Sharma, Gaurav Pirpiris, Marinis Love, David Bucknill, Andrew Farrugia, Richard J. Pape, Hans-Christoph Knobe, Matthias Pfeifer, Roman Hull, Peter Lewis, Sophie Evans, Simone Nanda, Rajesh Logishetty, Rajanikanth Anand, Sanjeev Bowler, Carol Dadi, Akhil Palla, Naveen Ganguly, Utsav Rai, B. Sachidananda Rajakumar, Janakiraman Jennings, Andrew Chuter, Graham Rose, Glynis Horner, Gillian Clark, Callum Eke, Kate Reed, Mike Herriott, Chris Dobb, Christine Bhandari, Mohit Swiontkowski, Marc Devereaux, Pj Schemitsch, Emil H. Heetveld, Martin J. Jeray, Kyle Liew, Susan Thabane, Lehana Walter, Stephen Sprague, Sheila Scott, Taryn Guyatt, Gordon Bhandari, Mohit Swiontkowski, Marc Devereaux, Pj Guyatt, Gordon Heetveld, Martin J. Jeray, Kyle Liew, Susan Schemitsch, Emil H. Thabane, Lehana Walter, Stephen Bhandari, Mohit Sprague, Sheila Viveiros, Helena McKay, Paula Scott, Taryn Swinton, Marilyn Truong, Victoria Koo, Kaitlin Heels-Ansdell, Diane Zhou, Qi Buckingham, Lisa Duraikannan, Aravin Maddock, Deborah Simunovic, Nicole Swiontkowski, Marc Agel, Julie Heetveld, Martin J. Van Lieshout, Esther M. M. Zielinski, Stephanie M. Rangan, Amar Hanusch, Birgit C. Kottam, Lucksy Clarkson, Rachel Della Rocca, Gregory J. Haverlag, Robert Liew, Susan Slobogean, Gerard Katz, Jeffrey Gillespie, Brenda Greendale, Gail A. Guy, Pierre Hartman, Curtis Rubin, Craig Waddell, James CA FAITH Investigators TI Fixation using alternative implants for the treatment of hip fractures (FAITH): design and rationale for a multi-centre randomized trial comparing sliding hip screws and cancellous screws on revision surgery rates and quality of life in the treatment of femoral neck fractures SO BMC MUSCULOSKELETAL DISORDERS LA English DT Article DE Hip fractures; Femoral neck fractures; Fracture fixation; Internal fixation; Cancellous screws; Sliding hip screw ID 2-YEAR FOLLOW-UP; INTERNAL-FIXATION; DISPLACED FRACTURES; SHORT-FORM; UNITED-STATES; DYNAMIC HIP; ARTHROPLASTY; METAANALYSIS; OUTCOMES; HEMIARTHROPLASTY AB Background: Hip fractures are a common type of fragility fracture that afflict 293,000 Americans (over 5,000 per week) and 35,000 Canadians (over 670 per week) annually. Despite the large population impact the optimal fixation technique for low energy femoral neck fractures remains controversial. The primary objective of the FAITH study is to assess the impact of cancellous screw fixation versus sliding hip screws on rates of revision surgery at 24 months in individuals with femoral neck fractures. The secondary objective is to determine the impact on health-related quality of life, functional outcomes, health state utilities, fracture healing, mortality and fracture-related adverse events. Methods/Design: FAITH is a multi-centre, multi-national randomized controlled trial utilizing minimization to determine patient allocation. Surgeons in North America, Europe, Australia, and Asia will recruit a total of at least 1,000 patients with low-energy femoral neck fractures. Using central randomization, patients will be allocated to receive surgical treatment with cancellous screws or a sliding hip screw. Patient outcomes will be assessed at one week (baseline), 10 weeks, 6, 12, 18, and 24 months post initial fixation. We will independently adjudicate revision surgery and complications within 24 months of the initial fixation. Outcome analysis will be performed using a Cox proportional hazards model and likelihood ratio test. Discussion: This study represents major international efforts to definitively resolve the treatment of low-energy femoral neck fractures. This trial will not only change current Orthopaedic practice, but will also set a benchmark for the conduct of future Orthopaedic trials. C1 [McCormack, Robert; Apostle, Kelly; Boyer, Dory; Moola, Farhad; Perey, Bertrand; Stone, Trevor; Viskontas, Darius; Lemke, H. Michael; Zomar, Mauri; Moon, Karyn; Moon, Raely; Oatt, Amber] Univ British Columbia, Fraser Hlth Author, Vancouver, BC V5Z 1M9, Canada. [Buckley, Richard E.; Duffy, Paul; Korley, Robert; Puloski, Shannon; Johnston, Kelly; Powell, James; Carcary, Kimberly] Foothills Med Ctr, Calgary, AB, Canada. [Sanders, David; Lawendy, Abdel; Tieszer, Christina] London Hlth Sci Ctr, London, ON, Canada. [Stephen, David; Kreder, Hans; Jenkinson, Richard; Nousiainen, Markku; Axelrod, Terry; Murnaghan, John; Nam, Diane; Wadey, Veronica; Yee, Albert; Milner, Katrine; Kunz, Monica] Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada. [Schemitsch, Emil H.; Ahn, Henry; Hall, Jeremy A.; McKee, Michael D.; Whelan, Daniel B.; Nauth, Aaron; Vicente, Milena R.; Wild, Lisa M.; Khan, Ryan M.; Hidy, Jennifer T.] St Michaels Hosp, Toronto, ON, Canada. [Coles, Chad; Leighton, Ross; Biddulph, Michael; Johnston, David; Glazebrook, Mark; Alexander, David; Coady, Cathy; Dunbar, Michael; Amirault, David; Gross, Michael; Oxner, William; Reardon, Gerald; Richardson, Glen; Trenholm, Andrew; Wong, Ivan; Trask, Kelly; MacDonald, Shelley; Dobbin, Gwen] Queen Elizabeth 2 Hlth Sci Ctr, Halifax, NS, Canada. [Bicknell, Ryan; Yach, Jeff; Bardana, Davide; Wood, Gavin; Harrison, Mark; Yen, David; Lambert, Sue; Howells, Fiona; Ward, Angela] Queens Univ, Human Mobil Res Ctr, Kingston, ON K7L 3N6, Canada. [Bicknell, Ryan; Yach, Jeff; Bardana, Davide; Wood, Gavin; Harrison, Mark; Yen, David; Lambert, Sue; Howells, Fiona; Ward, Angela] Kingston Gen Hosp, Kingston, ON, Canada. [Zalzal, Paul; Brien, Heather; Naumetz, V.; Weening, Brad; Simunovic, Nicole] Oakville Trafalgar Mem Hosp, Oakville, ON, Canada. [Wai, Eugene K.; Papp, Steve; Gofton, Wade T.; Liew, Allen; Kingwell, Stephen P.; Johnson, Garth; O'Neil, Joseph; Roffey, Darren M.; Borsella, Vivian] Ottawa Hosp, Ottawa, ON, Canada. [Avram, Victoria] Juravinski Hosp & Canc Ctr, Hamilton, ON, Canada. [Oliver, Todd M.; Jones, Vicki] Boone Hosp Ctr, Columbia Orthopaed Grp, Columbia, MO USA. [Jones, Clifford B.; Ringler, James R.; Endres, Terrence J.; Sietsema, Debra L.] Orthopaed Associates Michigan, Grand Rapids, MI USA. [Jeray, Kyle J.; Broderick, J. Scott; Goetz, David R.; Pace, Thomas B.; Schaller, Thomas M.; Porter, Scott E.; Tanner, Stephanie L.; Snider, Rebecca G.; Nastoff, Lauren A.; Bielby, Shea A.] Greenville Hosp Syst, Greenville, SC USA. [Switzer, Julie A.; Cole, Peter A.; Anderson, Sarah A.; Lafferty, Paul M.; Li, Mengnai; Ly, Thuan V.; Marston, Scott B.; Foley, Amy L.; Vang, Sandy; Wright, David M.] Reg Hosp Univ Minnesota, Minneapolis, MN USA. [Marcantonio, Andrew J.; Kain, Michael S. H.; Iorio, Richard; Specht, Lawrence M.; Tilzey, John F.; Lobo, Margaret J.; Garfi, John S.] Lahey Hosp & Med Ctr, Burlington, MA USA. [Vallier, Heather A.; Dolenc, Andrea; Robinson, Chalitha] Metrohlth Med Ctr, Cleveland, OH USA. [Prayson, Michael J.; Laughlin, Richard; Rubino, L. Joseph; May, Jedediah; Rieser, Geoffrey Ryan; Dulaney-Cripe, Liz; Gayton, Chris] Miami Valley Hosp, Dayton, OH USA. [Shaer, James; Schrickel, Tyson; Hileman, Barbara] St Elizabeth Hlth Ctr, Youngstown, OH USA. [Gorczyca, John T.; Gross, Jonathan M.; Humphrey, Catherine A.; Kates, Stephen; Noble, Krista; McIntyre, Allison W.; Pecorella, Kaili] Univ Rochester, Med Ctr, Rochester, NY 14627 USA. [Davis, Craig A.; Weinerman, Stewart; Weingarten, Peter; Stull, Philip; Lindenbaum, Stephen; Hewitt, Michael; Schwappach, John; Baker, Janell K.; Rutherford, Tori; Newman, Heike; Lieberman, Shane; Finn, Erin; Robbins, Kristin; Hurley, Meghan; Lyle, Lindsey; Mitchell, Khalis; Browner, Kieran; Whatley, Erica; Payton, Krystal; Reeves, Christina] Colorado Orthoped Consultants, Aurora, CO USA. [Cannada, Lisa K.; Karges, David; Hill, Leslie] St Louis Univ Hosp, St Louis, MO USA. [Mehta, Samir; Esterhai, John; Ahn, Jaimo; Horan, Annamarie D.; McGinnis, Kelly; Kaminski, Christine A.; Kowalski, Brynn N.] Univ Penn, Philadelphia, PA 19104 USA. [Keeve, Jonathan P.; Anderson, Christopher G.; McDonald, Michael D.; Hoffman, Jodi M.] Northwest Orthopaed Specialists, Spokane, WA USA. [Tarkin, Ivan; Siska, Peter; Gruen, Gary; Evans, Andrew; Farrell, Dana J.; Irrgang, James; Luther, Arlene] Univ Pittsburgh, Med Ctr, Pittsburgh, PA 15260 USA. [Cross, William W., III; Cass, Joseph R.; Sems, Stephen A.; Torchia, Michael E.; Scrabeck, Tyson] Mayo Clin, Scottsdale, AZ USA. [Jenkins, Mark; Dumais, Jules; Romero, Amanda W.] Texas Tech Univ, Hlth Sci Ctr Lubbock, Lubbock, TX 79409 USA. [Sagebien, Carlos A.; Butler, Mark S.; Monica, James T.; Seuffert, Patricia] Univ Orthopaed Associates LLC, Somerset, NJ USA. [Hsu, Joseph R.; Ficke, James; Charlton, Michael; Napierala, Matthew; Fan, Mary] US Army, Inst Surg Res, New York, NY USA. [Tornetta, Paul, III; Tannoury, Chadi; Carlisle, Hope; Silva, Heather] Boston Univ, Ctr Med, Boston, MA 02215 USA. [Archdeacon, Michael; Finnan, Ryan; Le, Toan; Wyrick, John; Hess, Shelley] Univ Cincinnati, Ctr Med, UC Hlth, Cincinnati, OH 45221 USA. [Brennan, Michael L.; Probe, Robert; Kile, Evelyn; Mills, Kelli; Clipper, Lydia; Yu, Michelle; Erwin, Katie] Scott & White Mem Hosp & Clin, Temple, TX 76508 USA. [Horwitz, Daniel; Strohecker, Kent; Swenson, Teresa K.] Geisinger Med Ctr, Danville, PA USA. Hennepin Cty Med Ctr, Minneapolis, MN USA. [Aurang, Kamran; Zohman, Gary; Peterson, Brett; Huff, Roger B.] Kaiser Permanente, Sidney, BC, Canada. [Baele, Joseph; Weber, Timothy; Edison, Matt] OrthoIndy, Fishers, IN USA. [McBeth, Jessica] Santa Clara Valley Med Ctr, Santa Clara, CA USA. [Shively, Karl; Ertl, Janos P.; Mullis, Brian; Parr, J. Andrew; Worman, Ripley; Frizzell, Valda; Moore, Molly M.; Tobias, Erin; Thomas, Emily] Indiana Univ, Wishard Hlth Serv, Bloomington, IN 47405 USA. [DePaolo, Charles J.; Alosky, Rachel; Shell, Leslie E.; Hampton, Lynne; Shepard, Stephanie; Nanney, Tracy; Cuento, Claudine] Mission Hosp Res Inst, New York, NY USA. [Cantu, Robert V.; Henderson, Eric R.; Eickhoff, Linda S.] Dartmouth Hitchcock Med Ctr, Lebanon, NH USA. [Hammerberg, E. Mark; Stahel, Philip; Hak, David; Mauffrey, Cyril; Gibula, Douglas; Gissel, Hannah; Henderson, Corey] Denver Hlth & Hosp Author, Denver, CO USA. [Zamorano, David P.; Tynan, Martin C.; Pourmand, Deeba; Lawson, Deanna] Univ Calif Irvine Med Ctr, Orange, CA USA. [Della Rocca, Gregory J.; Crist, Brett D.; Murtha, Yvonne M.; Anderson, Linda K.] Univ Missouri Hlth Care, Columbia, MO USA. [Linehan, Colleen; Pilling, Lindsey] Covenant Healthcare Saginaw, Saginaw, MI USA. [Lewis, Courtland G.; Caminiti, Stephanie; Sullivan, Raymond J.; Roper, Elizabeth] Hartford Hosp, Hartford, CT USA. [Obremskey, William; Kregor, Philip; Richards, Justin E.; Stringfellow, Kenya] Vanderbilt Univ, Med Ctr, Nashville, TN USA. [Dohm, Michael P.; Zellar, Abby] Western Slope Study Grp, Grand Junction, CO USA. [Segers, Michiel J. M.; Zijl, Jacco A. C.; Verhoeven, Bart; Smits, Anke B.; de Vries, Jean Paul P. M.; Fioole, Bram; van der Hoeven, Henk; Theunissen, Evert B. M.; Reilingh, Tammo S. de Vries; Govaert, Lonneke; Wittich, Philippe; de Brauw, Maurits; Wille, Jan; Go, Peter M. N. Y. M.; Ritchie, Ewan D.; Wessel, Ronald N.; Hammacher, Eric R.] St Antonius Hosp, Nieuwegein, Netherlands. [Heetveld, Martin J.; Visser, Gijs A.; Stockmann, Heyn; Silvis, Rob; Snellen, Jaap P.; Rijbroek, Bram; Scheepers, Joris J. G.; Vermeulen, Erik G. J.; Siroen, Michiel P. C.; Vuylsteke, Ronald; Brom, Hans L. F.; Rijna, Herman] Kennemer Gasthuis, Haarlem, Netherlands. [de Rijcke, Piet A. R.; Koppert, Cees L.; Buijk, Steven E.; Groenendijk, Richard P. R.; Dawson, Imro; Tetteroo, Geert W. M.; Bruijninckx, Milko M. M.; Doornebosch, Pascal G.; de Graaf, Eelco J. R.] IJsselland Ziekenhuis, Rotterdam, Netherlands. [van der Elst, Maarten; van der Pol, Carmen C.; van 't Riet, Martijne; Karsten, Tom M.; de Vries, Mark R.; Stassen, Laurents P. S.; Schep, Niels W. L.; Ben Schmidt, G.; Hoffman, W. H.] Reinier de Graaf Gasthuis, Delft, Netherlands. [Poolman, Rudolf W.; Simons, Maarten P.; van der Heijden, Frank H. W. M.; Willems, W. Jaap; de Meulemeester, Frank R. A. J.; van der Hart, Cor P.; Turckan, Kahn; Festen, Sebastiaan; de Nies, Frank; Haverlag, Robert; Out, Nico J. M.; Bosma, Jan] Onze Lieve Vrouw Hosp, Amsterdam, Netherlands. [van Kampen, Albert; Biert, Jan; van Vugt, Arie B.; Edwards, Michael J. R.; Blokhuis, Taco J.; Frolke, Jan Paul M.; Geeraedts, Leo M. G.; Gardeniers, Jean W. M.; Tan, Edward T. C. H.; Poelhekke, Lodewijk M. S. J.; Malefijt, Maarten C. de Waal; Schreurs, Bart] Radboud Univ Nijmegen Med Ctr, Nijmegen, Netherlands. [Roukema, Gert R.; Josaputra, Hong A.; Keller, Paul; de Rooij, Peter D.; Kuiken, Hans; Boxma, Han; Cleffken, Berry I.; Liem, Ronald] Maasstad Ziekenhuis, Rotterdam, Netherlands. [Rhemrev, Steven J.; Bosman, Coks H. R.; van Otterloo, Alexander de Mol; Hoogendoorn, Jochem; de Vries, Alexander C.; Meylaerts, Sven A. G.] Med Ctr Haaglanden, The Hague, Netherlands. [van der Heijden, Frank H. W. M.; Verhofstad, Michiel H. J.; Meijer, Joost; van Egmond, Teun; van der Brand, Igor] St Elizabeth Hosp, Tilburg, Netherlands. [Patka, Peter; Eversdijk, Martin G.; Peters, Rolf; Den Hartog, Dennis; Van Waes, Oscar J. F.; Oprel, Pim] Univ Med Ctr Rotterdam, Erasmus MC, Rotterdam, Netherlands. [van der Vis, Harm M.; Campo, Martin; Verhagen, Ronald; Albers, G. H. Robert; Zurcher, Arthur W.] Tergooi Ziekenhuizen, Hilversum, Netherlands. [Blokhuis, Taco J.; Simmermacher, Rogier K. J.; van Mulken, Jeroen; van Wessem, Karlijn; van Gaalen, Steven M.; Leenen, Luke P. H.] Univ Med Ctr Utrecht, Utrecht, Netherlands. [Bronkhorst, Maarten W. G. A.; Guicherit, Onno R.] Bronovo Ziekenhuis, The Hague, Netherlands. [Haverlag, Robert; Goslings, J. Carel; Ponsen, Kees Jan] Acad Med Ctr, Amsterdam, Netherlands. [Bhatia, Mahesh; Arora, Vinod; Tyagi, Vivek] RLB Hosp & Res Ctr, Indore, Madhya Pradesh, India. [Liew, Susan; Bedi, Harvinder; Carr, Ashley; Curry, Hamish; Chia, Andrew; Csongvay, Steve; Donohue, Craig; Doig, Stephen; Edwards, Elton; Etherington, Greg; Esser, Max; Gong, Andrew; Jain, Arvind; Li, Doug; Miller, Russell; Moaveni, Ash; Russ, Matthias; Ton, Lu; Wang, Otis; Dowrick, Adam; Murdoch, Zoe; Sage, Claire] The Alfred, Melbourne, Vic, Australia. [Frihagen, Frede; Clarke-Jenssen, John; Hjorthaug, Geir; Ianssen, Torben; Amundsen, Asgeir; Brattgjerd, Jan Egil; Borch, Tor; Boe, Berthe; Flatoy, Bernhard; Hasselund, Sondre; Haug, Knut Jorgen; Hemlock, Kim; Hoseth, Tor Magne; Jomaas, Geir; Kibsgard, Thomas; Lona, Tarjei; Moatshe, Gilbert; Muller, Oliver; Molund, Marius; Nicolaisen, Tor; Nilsen, Fredrik; Rydinge, Jonas; Smedsrud, Morten; Stodle, Are; Trommer, Axel; Ugland, Stein; Karlsten, Anders; Ekas, Guri; Vesterhus, Elise Berg; Brekke, Anne Christine] Oslo Univ Hosp, Oslo, Norway. [Gupta, Ajay; Jain, Neeraj; Khan, Farah] Nirmal Hosp, Surat, India. [Sharma, Ateet; Sanghavi, Amir; Trivedi, Mittal] Satellite Orthopaed Hosp & Res Ctr, Ahmadabad, Gujarat, India. [Rai, Anil; Subash; Rai, Kamal] Highway Hosp, Lucknow, Uttar Pradesh, India. [Rai, Kamal; Yadav, Vineet; Singh, Sanjay] Popular Hosp, Varanasi, Uttar Pradesh, India. [Tetsworth, Kevin; Donald, Geoff; Weinrauch, Patrick; Pincus, Paul; Yang, Steven; Halliday, Brett; Gervais, Trevor; Holt, Michael; Flynn, Annette] Royal Brisbane & Womens Hosp, Brisbane, Qld, Australia. [Prasad, Amal Shankar; Mishra, Vimlesh] Madhuraj Nursing Home, Kanpur, Uttar Pradesh, India. [Sundaresh, D. C.; Khanna, Angshuman] MS Rammaiah Med Coll & Hosp, Bangalore, Karnataka, India. [Cherian, Joe Joseph; Olakkengil, Davy J.; Sharma, Gaurav] St Johns Med Coll Hosp, Bangalore, Karnataka, India. [Pirpiris, Marinis; Love, David; Bucknill, Andrew; Farrugia, Richard J.] Royal Melbourne Hosp, Melbourne, Vic, Australia. [Pape, Hans-Christoph; Knobe, Matthias; Pfeifer, Roman] Univ Aachen, Med Ctr, Aachen, Germany. [Hull, Peter; Lewis, Sophie; Evans, Simone] Cambridge Univ Hosp, Cambridge, England. [Nanda, Rajesh; Logishetty, Rajanikanth; Anand, Sanjeev; Bowler, Carol] Univ Hosp North Tees, Cleveland, England. [Dadi, Akhil; Palla, Naveen; Ganguly, Utsav] Sunshine Hosp, Hyderabad, Andhra Pradesh, India. [Rai, B. Sachidananda; Rajakumar, Janakiraman] Unity Hlth Complex, Mangaluru, Karnataka, India. [Jennings, Andrew; Chuter, Graham; Rose, Glynis; Horner, Gillian] Univ Hosp North Durham, Durham, England. [Jennings, Andrew; Chuter, Graham; Rose, Glynis; Horner, Gillian] Darlington Mem Hosp, Darlington, Durham, England. [Clark, Callum; Eke, Kate] Wexham Pk Hosp, Slough, Berks, England. [Reed, Mike; Herriott, Chris; Dobb, Christine] Northumbria Healthcare NHS Fdn Trust, Newcastle Upon Tyne, Tyne & Wear, England. [Simunovic, Nicole; Maddock, Deborah] McMaster Univ, Hamilton, ON L8S 4L8, Canada. [Agel, Julie] Univ Minnesota, Minneapolis, MN 55455 USA. [Zielinski, Stephanie M.] Univ Med Ctr Rotterdam, Erasmus MC, Rotterdam, Netherlands. [Hanusch, Birgit C.; Kottam, Lucksy; Clarkson, Rachel] James Cook Univ Hosp, Middlesbrough, Cleveland, England. RP McCormack, R (reprint author), McMaster Univ, Div Orthopaed Surg, 293 Wellington St North,Suite 110, Hamilton, ON L8L 8E7, Canada. EM bhandam@mcmaster.ca RI CSTFA, ResearcherID/P-1067-2014; Biert, J./L-4200-2015; Kampen, A./H-8056-2014; Frolke, J.P.M./L-4312-2015; Schreurs, B.W./L-4639-2015 FU Canadian Institutes of Health Research (CIHR); National Institutes of Health (NIH); Stichting NutsOhra; Netherlands Organisation for Health Research and Development; Physicians' Services Incorporated; Canada Research Chair in Musculoskeletal Trauma; County Durham & Tees Valley Comprehensive Local Research Network FX Research grants were received from the following: Canadian Institutes of Health Research (CIHR) (PI: Mohit Bhandari); National Institutes of Health (NIH) (PI: Marc Swiontkowski); Stichting NutsOhra (PI: Martin J Heetveld), The Netherlands Organisation for Health Research and Development (PI: Esther M M Van Lieshout); Physicians' Services Incorporated (PI: Mohit Bhandari). Dr. Bhandari was also funded, in part, by a Canada Research Chair in Musculoskeletal Trauma which is unrelated to the present study (McMaster University, Hamilton, ON, Canada). We would also like to acknowledge the support of The County Durham & Tees Valley Comprehensive Local Research Network which operates as part of the National Institute for Health Research Comprehensive Clinical Research Network in England. The funding sources and study sponsor had no role in design or conduct of the study; the collection, management, analysis, or interpretation of the data; or writing of the report or the decision to submit the report for publication. Dr. Mohit Bhandari had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. NR 53 TC 0 Z9 0 U1 3 U2 19 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2474 J9 BMC MUSCULOSKEL DIS JI BMC Musculoskelet. Disord. PD JUN 26 PY 2014 VL 15 AR 219 DI 10.1186/1471-2474-15-219 PG 15 WC Orthopedics; Rheumatology SC Orthopedics; Rheumatology GA AO6KG UT WOS:000341459200001 ER PT J AU Chen, J Pan, HN Chen, C Wu, W Iskandar, K He, J Piermartiri, T Jacobowitz, DM Yu, QS McDonough, JH Greig, NH Marini, AM AF Chen, Jun Pan, Hongna Chen, Cynthia Wu, Wei Iskandar, Kevin He, Jeffrey Piermartiri, Tetsade Jacobowitz, David M. Yu, Qian-Sheng McDonough, John H. Greig, Nigel H. Marini, Ann M. TI (-)-Phenserine Attenuates Soman-Induced Neuropathology SO PLOS ONE LA English DT Article ID AMYLOID PRECURSOR PROTEIN; SUBWAY SARIN ATTACK; POSTTRAUMATIC-STRESS-DISORDER; ORGANOPHOSPHORUS NERVE AGENTS; ALZHEIMERS-DISEASE; INDUCED SEIZURES; ACETYLCHOLINESTERASE INHIBITION; CHOLINESTERASE-INHIBITORS; TRANSCRIPTION FACTOR; NEURONAL SURVIVAL AB Organophosphorus (OP) nerve agents are deadly chemical weapons that pose an alarming threat to military and civilian populations. The irreversible inhibition of the critical cholinergic degradative enzyme acetylcholinesterase (AChE) by OP nerve agents leads to cholinergic crisis. Resulting excessive synaptic acetylcholine levels leads to status epilepticus that, in turn, results in brain damage. Current countermeasures are only modestly effective in protecting against OP-induced brain damage, supporting interest for evaluation of new ones. (-)-Phenserine is a reversible AChE inhibitor possessing neuroprotective and amyloid precursor protein lowering actions that reached Phase III clinical trials for Alzheimer's Disease where it exhibited a wide safety margin. This compound preferentially enters the CNS and has potential to impede soman binding to the active site of AChE to, thereby, serve in a protective capacity. Herein, we demonstrate that (-)-phenserine protects neurons against soman-induced neuronal cell death in rats when administered either as a pretreatment or post-treatment paradigm, improves motoric movement in soman-exposed animals and reduces mortality when given as a pretreatment. Gene expression analysis, undertaken to elucidate mechanism, showed that (-)-phenserine pretreatment increased select neuroprotective genes and reversed a Homer1expression elevation induced by soman exposure. These studies suggest that (-)-phenserine warrants further evaluation as an OP nerve agent protective strategy. C1 [Chen, Jun; Pan, Hongna; Chen, Cynthia; Wu, Wei; Iskandar, Kevin; He, Jeffrey; Piermartiri, Tetsade; Marini, Ann M.] Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. [Jacobowitz, David M.] Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA. [Yu, Qian-Sheng; Greig, Nigel H.] NIA, Drug Design & Dev Sect, Translat Gerontol Branch, Intramural Res Program,NIH, Baltimore, MD 21224 USA. [McDonough, John H.] US Army Med Res Inst Chem Def, Pharmacol Branch, Div Res, Aberdeen Proving Ground, MD USA. RP Marini, AM (reprint author), Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. EM ann.marini@usuhs.edu OI Piermartiri, Tetsade/0000-0002-9773-6983 FU Defense Threat Reduction Agency-Joint Science and Technology Office, Medical ST Division [CBM.NEURO.01.10.US.012, CBM.NEURO.01.10.US.019]; Intramural Research Program, National Institute on Aging, National Institutes of Health FX This work was supported by Defense Threat Reduction Agency-Joint Science and Technology Office, Medical S&T Division [Grant Numbers CBM.NEURO.01.10.US.012 and CBM.NEURO.01.10.US.019] (AMM); Intramural Research Program, National Institute on Aging, National Institutes of Health (NHG). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 88 TC 3 Z9 4 U1 0 U2 10 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUN 23 PY 2014 VL 9 IS 6 AR e99818 DI 10.1371/journal.pone.0099818 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AL1WV UT WOS:000338917900019 PM 24955574 ER PT J AU Sablon, K Little, J Vagidov, N Li, Y Mitin, V Sergeev, A AF Sablon, K. Little, J. Vagidov, N. Li, Y. Mitin, V. Sergeev, A. TI Conversion of above- and below-bandgap photons via InAs quantum dot media embedded into GaAs solar cell SO APPLIED PHYSICS LETTERS LA English DT Article ID EFFICIENCY; ENERGY; NANOCRYSTALS; IMPROVEMENT; DEPENDENCE; CHARGE AB Quantum dots (QDs) provide photovoltaic conversion of below-bandgap photons due to multistep electron transitions. QDs also increase conversion efficiency of the above-bandgap photons due to extraction of electrons from QDs via Coulomb interaction with hot electrons excited by high-energy photons. Nanoscale potential profile (potential barriers) and nanoscale band engineering (AlGaAs atomically thin barriers) allow for suppression of photoelectron capture to QDs. To study these kinetic effects and to distinguish them from the absorption enhancement due to light scattering on QDs, we investigate long, 3-mu m base GaAs devices with various InAs QD media with 20 and 40 QD layers. Quantum efficiency measurements show that, at least at low doping, the multistep processes in QD media are strongly affected by the wetting layer (WL). The QD media with WLs provide substantial conversion of below-bandgap photons and for devices with 40 QD layers the short circuit current reaches 29.2 mA/cm(2). The QD media with band-engineered AlGaAs barriers and reduced wetting layers (RWL) enhance conversion of high-energy photons and decrease the relaxation (thermal) losses. (C) 2014 AIP Publishing LLC. C1 [Sablon, K.; Little, J.] US Army Res Lab, Adelphi, MD 20783 USA. [Vagidov, N.] Optoelect Nanodevices LLC, Amherst, NY 14226 USA. [Li, Y.; Mitin, V.; Sergeev, A.] SUNY Buffalo, EE Dept, Buffalo, NY 14260 USA. RP Sablon, K (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. FU ARL; AFRL [FA9453-14-M-0013]; NSF [ECS-1236459]; AFOSR [FA9550-10-1-0391] FX The work of K. S. and J.L. was supported by ARL, work of N.V. by AFRL (FA9453-14-M-0013), work of Y. Li and A. S. by NSF (ECS-1236459), and work of V. M. by AFOSR (FA9550-10-1-0391). The authors are grateful to D. Wilt and S. Oktyabrsky for valuable discussions and highly appreciate Michael Yakimov's help in SIMS and EDXS analyses of our devices. NR 25 TC 11 Z9 11 U1 1 U2 25 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUN 23 PY 2014 VL 104 IS 25 AR 253904 DI 10.1063/1.4885113 PG 5 WC Physics, Applied SC Physics GA AK6CQ UT WOS:000338515900101 ER PT J AU Tschopp, MA Gao, F Solanki, KN AF Tschopp, M. A. Gao, F. Solanki, K. N. TI Binding of HenV clusters to alpha-Fe grain boundaries SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID HELIUM-VACANCY CLUSTERS; MOLECULAR-DYNAMICS; BCC IRON; DISPLACEMENT CASCADES; STRUCTURAL-MATERIALS; DEFECT PRODUCTION; TENSILE-STRENGTH; ENERGY; FUSION; IRRADIATION AB The objective of this research is to explore the formation/binding energetics and length scales associated with the interaction between HenV clusters and grain boundaries in bcc alpha-Fe. In this work, we calculated formation/binding energies for 1-8 He atoms in a monovacancy at all potential grain boundary (GB) sites within 15 angstrom of the ten grain boundaries selected (122106 simulations total). The present results provide detailed information about the interaction energies and length scales of 1-8 He atoms with grain boundaries for the structures examined. A number of interesting new findings emerge from the present study. First, the Sigma 3(112) "twin" GB has significantly lower binding energies for all HenV clusters than all other boundaries in this study. For all grain boundary sites, the effect of the local environment surrounding each site on the HenV formation and binding energies decreases with an increasing number of He atoms in the HenV cluster. Based on the calculated dataset, we formulated a model to capture the evolution of the formation and binding energy of HenV clusters as a function of distance from the GB center, utilizing only constants related to the maximum binding energy and the length scale. (C) 2014 AIP Publishing LLC. C1 [Tschopp, M. A.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Gao, F.] Pacific NW Natl Lab, Richland, WA 99352 USA. [Solanki, K. N.] Arizona State Univ, Tempe, AZ 85287 USA. RP Tschopp, MA (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM mark.a.tschopp.civ@mail.mil RI Solanki, Kiran/E-8337-2010; OI Tschopp, Mark/0000-0001-8471-5035 FU U.S. Army Research Laboratory (ARL); U.S. Department of Energy, Office of Fusion Energy Science [DE-AC06-76RLO 1830]; Alternate Sponsored Fellowship (ASF) at PNNL FX This work was supported in part by the U.S. Army Research Laboratory (ARL). F. G. is grateful for the support by the U.S. Department of Energy, Office of Fusion Energy Science, under Contract DE-AC06-76RLO 1830. The authors would like to acknowledge the support and discussions with Dr. Xin Sun at Pacific Northwest National Laboratory. Last, the authors would like to acknowledge Ms. Joanna Sun, a high school student support by the Alternate Sponsored Fellowship (ASF) at PNNL, for her contributions to this work. NR 83 TC 5 Z9 5 U1 4 U2 37 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD JUN 21 PY 2014 VL 115 IS 23 AR 233501 DI 10.1063/1.4883357 PG 15 WC Physics, Applied SC Physics GA AK0MB UT WOS:000338106000009 ER PT J AU Liu, RF Singh, N Tawa, GJ Wallqvist, A Reifman, J AF Liu, Ruifeng Singh, Narender Tawa, Gregory J. Wallqvist, Anders Reifman, Jaques TI Exploiting large-scale drug-protein interaction information for computational drug repurposing SO BMC BIOINFORMATICS LA English DT Article DE Drug repurposing; Bayes theorem; Drug-protein interaction; Mechanism of drug action ID PLASMODIUM-FALCIPARUM; CEREBRAL MALARIA; MULTIPLE-MYELOMA; DEXAMETHASONE; THALIDOMIDE; PARASITE; IDENTIFICATION; MECHANISMS; HEMORRHAGE; RESISTANCE AB Background: Despite increased investment in pharmaceutical research and development, fewer and fewer new drugs are entering the marketplace. This has prompted studies in repurposing existing drugs for use against diseases with unmet medical needs. A popular approach is to develop a classification model based on drugs with and without a desired therapeutic effect. For this approach to be statistically sound, it requires a large number of drugs in both classes. However, given few or no approved drugs for the diseases of highest medical urgency and interest, different strategies need to be investigated. Results: We developed a computational method termed "drug-protein interaction-based repurposing" (DPIR) that is potentially applicable to diseases with very few approved drugs. The method, based on genome-wide drug-protein interaction information and Bayesian statistics, first identifies drug-protein interactions associated with a desired therapeutic effect. Then, it uses key drug-protein interactions to score other drugs for their potential to have the same therapeutic effect. Conclusions: Detailed cross-validation studies using United States Food and Drug Administration-approved drugs for hypertension, human immunodeficiency virus, and malaria indicated that DPIR provides robust predictions. It achieves high levels of enrichment of drugs approved for a disease even with models developed based on a single drug known to treat the disease. Analysis of our model predictions also indicated that the method is potentially useful for understanding molecular mechanisms of drug action and for identifying protein targets that may potentiate the desired therapeutic effects of other drugs (combination therapies). C1 [Liu, Ruifeng; Singh, Narender; Tawa, Gregory J.; Wallqvist, Anders; Reifman, Jaques] US Army, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Software Applicat Inst,Dept Def Biotechnol High P, Ft Detrick, MD 21702 USA. RP Liu, RF (reprint author), US Army, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Software Applicat Inst,Dept Def Biotechnol High P, Ft Detrick, MD 21702 USA. EM RLiu@bhsai.org; AWallqvist@bhsai.org OI wallqvist, anders/0000-0002-9775-7469 FU U.S. Army Medical Research and Materiel Command (Ft. Detrick, MD), as part of the U.S. Army's Network Science Initiative FX The authors were supported by the U.S. Army Medical Research and Materiel Command (Ft. Detrick, MD), as part of the U.S. Army's Network Science Initiative. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or of the U.S. Department of Defense. This paper has been approved for public release with unlimited distribution. NR 51 TC 6 Z9 6 U1 1 U2 10 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2105 J9 BMC BIOINFORMATICS JI BMC Bioinformatics PD JUN 20 PY 2014 VL 15 AR 210 DI 10.1186/1471-2105-15-210 PG 16 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Mathematical & Computational Biology GA AK2QM UT WOS:000338264200002 PM 24950817 ER PT J AU Faraone, A Fratini, E Garai, S Muller, A Tyagi, M Jenkins, T Mamontov, E Paul, RL Copley, JRD Baglioni, P AF Faraone, Antonio Fratini, Emiliano Garai, Somenath Mueller, Achim Tyagi, Madhusudan Jenkins, Timothy Mamontov, Eugene Paul, Rick L. Copley, John R. D. Baglioni, Piero TI Incoherent Quasielastic Neutron Scattering Study of the Relaxation Dynamics in Molybdenum-Oxide Keplerate-Type Nanocages SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID METHYL-GROUP DYNAMICS; HYDRATION WATER DYNAMICS; SINGLE-PARTICLE DYNAMICS; HYDROGEN-BONDED LIQUIDS; MOLECULAR-DYNAMICS; SUPERCOOLED WATER; MESOSCOPIC CONFINEMENT; ENCAPSULATED WATER; DIFFUSIVE MOTIONS; INTERNAL DYNAMICS AB The single-particle relaxation dynamics of hydrogen atoms in different oxomolybdate Keplerate-type nanocages characterized by a (metal)(30) icosahedron and a size of approximate to 2.5 nm were studied using incoherent quasielastic neutron scattering. Measurements were performed on a compound with a {Mo72Cr30} nanocage containing internal acetate ligands and a sodium cation coordinated to 12 water molecules. Because of the presence of the methyl groups of the acetate ligands, the related cavity is mostly hydrophobic and represents an interesting model system for investigating the properties of water molecules under confined conditions in contact with hydrophobic surfaces. The single-particle dynamics of both the methyl groups and the water molecules inside the cavity were studied and characterized to. be thermally activated processes. The volume explored by the hydrogen atoms during their motions was also determined. Elastic scan measurements of the {Mo72Cr30} cage, in comparison with the {Mo72V30} cage, which has the same skeletal structure as {Mo72Cr30} but a hydrophilic interior, have allowed an investigation into the vibrational dynamics of the cages themselves and the determination of the effect of the cage polarity. C1 [Faraone, Antonio; Tyagi, Madhusudan; Jenkins, Timothy; Copley, John R. D.] NIST, Ctr Neutron Res, Gaithersburg, MD 20899 USA. [Faraone, Antonio; Tyagi, Madhusudan] Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA. [Fratini, Emiliano; Baglioni, Piero] Univ Florence, Dept Chem Ugo Schiff, I-50019 Florence, Italy. [Fratini, Emiliano; Baglioni, Piero] Univ Florence, CSGI, I-50019 Florence, Italy. [Garai, Somenath; Mueller, Achim] Univ Bielefeld, Fak Chem, D-33615 Bielefeld, Germany. [Paul, Rick L.] NIST, Mat Measurement Lab, Div Analyt Chem, Gaithersburg, MD 20899 USA. [Jenkins, Timothy] US Army Res Lab, Adelphi, MD 21005 USA. [Mamontov, Eugene] Oak Ridge Natl Lab, Spallat Neutron Source, Oak Ridge, TN 37831 USA. RP Faraone, A (reprint author), NIST, Ctr Neutron Res, 100 Bur Dr, Gaithersburg, MD 20899 USA. EM antonio.faraone@nist.gov; piero.baglioni@unifi.it RI Tyagi, Madhu Sudan/M-4693-2014; Mamontov, Eugene/Q-1003-2015; Baglioni, Piero/B-1208-2011; OI Tyagi, Madhu Sudan/0000-0002-4364-7176; Mamontov, Eugene/0000-0002-5684-2675; Baglioni, Piero/0000-0003-1312-8700; Muller, Achim/0000-0003-0117-4021 FU ERC (Brussels); National Science Foundation [DMR-0944772]; Scientific User Facilities Division, Office of Basic Energy Sciences, U.S. Department of Energy (DOE); Consorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase, CSGI; Minister dell'Istruzione, Universita e della Ricerca Scientifica, MiUR FX We thank Dr. A.M. Todea for initial experiments. The authors are indebted to Dr. R. Bindel for performing some of the PGAA measurements. A.M. thanks the ERC (Brussels) for an Advanced Grant. This work utilized facilities supported in part by the National Science Foundation under Agreement No. DMR-0944772. The neutron scattering experiments at Oak Ridge National Laboratory's (ORNL) Spallation Neutron Source were supported by the Scientific User Facilities Division, Office of Basic Energy Sciences, U.S. Department of Energy (DOE). E.F. and P.B. acknowledge financial support from Consorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase, CSGI, and Minister dell'Istruzione, Universita e della Ricerca Scientifica, MiUR. NR 70 TC 3 Z9 3 U1 2 U2 31 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD JUN 19 PY 2014 VL 118 IS 24 BP 13300 EP 13312 DI 10.1021/jp504547z PG 13 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA AJ6FA UT WOS:000337783900078 ER PT J AU Brennan, JK Lisal, M Moore, JD Izvekov, S Schweigert, IV Larentzos, JP AF Brennan, John K. Lisal, Martin Moore, Joshua D. Izvekov, Sergei Schweigert, Igor V. Larentzos, James P. TI Coarse-Grain Model Simulations of Nonequilibrium Dynamics in Heterogeneous Materials SO JOURNAL OF PHYSICAL CHEMISTRY LETTERS LA English DT Article ID DISSIPATIVE PARTICLE DYNAMICS; ENERGY-CONSERVATION; MOLECULAR-DYNAMICS; DETONATION; SYSTEMS; COMBUSTION; ALGORITHMS; MIXTURES; SHOCK; RDX AB A suite of computational tools is described for particle-based mesoscale simulations of the nonequilibrium dynamics of energetic solids, including mechanical deformation, phase transitions, and chemical reactivity triggered by shock or thermal loading. The method builds upon our recent advances both in generating coarse-grain models under high strains and in developing a variant of dissipative particle dynamics (DPD) that includes chemical reactions. To describe chemical reactivity, a coarse-grain particle equation-of-state was introduced into the constant-energy DPD variant that rigorously treats complex chemical reactions and the associated chemical energy release. As illustration of these developments, we present simulations of shock compression of an RDX crystal and its thermal decomposition under high temperatures. We also discuss our current efforts toward a highly scalable domain-decomposition implementation that extends applicability to micrometer-size simulations. With appropriate parametrization, the method is applicable to other materials whose dynamic response is driven by microstructural heterogeneities. C1 [Brennan, John K.; Moore, Joshua D.; Izvekov, Sergei] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Lisal, Martin] ASCR, Inst Chem Proc Fundamentals, Lab Chem & Phys Aerosols, Vvi, Prague 16502, Czech Republic. [Lisal, Martin] Univ JE Purkyne, Fac Sci, Dept Phys, Usti Nad Labem 40096, Czech Republic. [Schweigert, Igor V.] US Naval Res Lab, Theoret Chem Sect, Washington, DC 20375 USA. [Larentzos, James P.] US Army Res Lab, Engil Corp, High Performance Technol Grp, Aberdeen Proving Ground, MD 21005 USA. RP Brennan, JK (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM john.k.brennan.civ@mail.mil RI Lisal, Martin/A-8176-2011; Schweigert, Igor/B-5750-2008 OI Lisal, Martin/0000-0001-8005-7143; FU Office of Naval Research; Department of Defense; ARL [W911NF-10-2-0039]; Czech Science Foundation [13-02938S] FX The authors acknowledge various scientists for insightful and stimulating discussions, namely, Jean-Bernard Maillet (Commissariat a l'energie atomique et aux energies alternatives, DAM), Gabriel Stoltz (CERMICS-Ecole des Ponts Paris Tech), Timothy W. Sirk, William D. Mattson, Michael S. Sellers, and Betsy M. Rice (U.S. Army Research Laboratory). The authors also acknowledge financial support from various sources, including the Office of Naval Research, the Department of Defense High Performance Computing Modernization Program Software Application Institute for Multiscale Reactive Modeling of Insensitive Munitions, ARL under Cooperative Agreement W911NF-10-2-0039, and the Czech Science Foundation under Project 13-02938S. Computer time was partially provided by the METACentrum computing facility. NR 44 TC 15 Z9 15 U1 7 U2 72 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1948-7185 J9 J PHYS CHEM LETT JI J. Phys. Chem. Lett. PD JUN 19 PY 2014 VL 5 IS 12 BP 2144 EP 2149 DI 10.1021/jz500756s PG 6 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Atomic, Molecular & Chemical SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA AJ7IJ UT WOS:000337870100016 PM 26270506 ER PT J AU Edmonds, JM Sabol, JP Rastogi, VK AF Edmonds, Jason M. Sabol, Jonathan P. Rastogi, Vipin K. TI Decontamination Efficacy of Three Commercial-Off-The-Shelf (COTS) Sporicidal Disinfectants on Medium-Sized Panels Contaminated with Surrogate Spores of Bacillus anthracis SO PLOS ONE LA English DT Article ID CHLORINE DIOXIDE GAS; SURFACES; THURINGIENSIS AB In the event of a wide area release and contamination of a biological agent in an outdoor environment and to building exteriors, decontamination is likely to consume the Nation's remediation capacity, requiring years to cleanup, and leading to incalculable economic losses. This is in part due to scant body of efficacy data on surface areas larger than those studied in a typical laboratory (5x10-cm), resulting in low confidence for operational considerations in sampling and quantitative measurements of prospective technologies recruited in effective cleanup and restoration response. In addition to well-documented fumigation-based cleanup efforts, agencies responsible for mitigation of contaminated sites are exploring alternative methods for decontamination including combinations of disposal of contaminated items, source reduction by vacuuming, mechanical scrubbing, and low-technology alternatives such as pH-adjusted bleach pressure wash. If proven effective, a pressure wash-based removal of Bacillus anthracis spores from building surfaces with readily available equipment will significantly increase the readiness of Federal agencies to meet the daunting challenge of restoration and cleanup effort following a wide-area biological release. In this inter-agency study, the efficacy of commercial-of-the-shelf sporicidal disinfectants applied using backpack sprayers was evaluated in decontamination of spores on the surfaces of medium-sized (similar to 1.2 m(2)) panels of steel, pressure-treated (PT) lumber, and brick veneer. Of the three disinfectants, pH-amended bleach, Peridox, and CASCAD evaluated; CASCAD was found to be the most effective in decontamination of spores from all three panel surface types. C1 [Edmonds, Jason M.; Rastogi, Vipin K.] US Army, Edgewood Chem Biol Ctr, Res Dev & Engn Command, Aberdeen Proving Ground, MD 21005 USA. [Sabol, Jonathan P.] EXCET Inc, Springfield, VA USA. RP Rastogi, VK (reprint author), US Army, Edgewood Chem Biol Ctr, Res Dev & Engn Command, Aberdeen Proving Ground, MD 21005 USA. EM vipin.k.rastogi.civ@mail.mil FU Joint Science and Technology Office of the Defense Threat Reduction Agency FX Funding for this program was provided by the Joint Science and Technology Office of the Defense Threat Reduction Agency. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 16 TC 0 Z9 0 U1 2 U2 8 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUN 18 PY 2014 VL 9 IS 6 AR e99827 DI 10.1371/journal.pone.0099827 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AK6AC UT WOS:000338508200044 PM 24940605 ER PT J AU Peela, NR Sutton, JE Lee, IC Vlachos, DG AF Peela, Nageswara Rao Sutton, Jonathan E. Lee, Ivan C. Vlachos, Dionisios G. TI Microkinetic Modeling of Ethane Total Oxidation on Pt SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH LA English DT Article ID DENSITY-FUNCTIONAL THEORY; NOBLE-METAL CATALYSTS; LOW-TEMPERATURE; CHEMISORBED OXYGEN; PROPANE OXIDATION; CO OXIDATION; LEAN METHANE; AIR MIXTURES; ALKANES; COMBUSTION AB Catalytic total oxidation is important in several applications. However, associated models are rather empirical. In this study, a microkinetic model is developed for ethane total oxidation, under fuel-lean conditions on a Pt catalyst using input from density functional theory and Bronsted-Evans-Polanyi linear free energy relations. Reaction orders and the apparent activation energy estimated from the model are in good agreement with experimental values. The inclusion of oxygen coverage effects on the activation of ethane changes the rate-determining step from thermal dehydrogenation to oxidative dehydrogenation of ethane. A significant portion (30%) of the reaction flux proceeds via oxygen insertion reactions to C-2 hydrocarbons (CH2C*). C1 [Peela, Nageswara Rao; Sutton, Jonathan E.; Vlachos, Dionisios G.] Univ Delaware, Dept Chem & Biomol Engn, Ctr Catalyt Sci & Technol, Newark, DE 19716 USA. [Peela, Nageswara Rao; Sutton, Jonathan E.; Vlachos, Dionisios G.] Univ Delaware, Catalysis Ctr Energy Innovat, Newark, DE 19716 USA. [Lee, Ivan C.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Vlachos, DG (reprint author), Univ Delaware, Dept Chem & Biomol Engn, Ctr Catalyt Sci & Technol, 150 Acad St, Newark, DE 19716 USA. EM vlachos@udel.edu OI Vlachos, Dionisios/0000-0002-6795-8403 FU Army Research Laboratory; National Science Foundation [CBET-940768] FX Part of this research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-10-2-0047. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon. J.E. Sutton's work was supported by the National Science Foundation (Award No. CBET-940768). NR 47 TC 3 Z9 3 U1 0 U2 37 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0888-5885 J9 IND ENG CHEM RES JI Ind. Eng. Chem. Res. PD JUN 18 PY 2014 VL 53 IS 24 BP 10051 EP 10058 DI 10.1021/ie5004587 PG 8 WC Engineering, Chemical SC Engineering GA AJ5KG UT WOS:000337720500012 ER PT J AU Warfield, KL Goetzmann, JE Biggins, JE Kasda, MB Unfer, RC Vu, H Aman, MJ Olinger, GG Walsh, PD AF Warfield, Kelly L. Goetzmann, Jason E. Biggins, Julia E. Kasda, Mary Beth Unfer, Robert C. Vu, Hong Aman, M. Javad Olinger, Gene Gerrard, Jr. Walsh, Peter D. TI Vaccinating captive chimpanzees to save wild chimpanzees SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE conservation; wildlife disease; filovirus ID EBOLA-VIRUS INFECTION; NONHUMAN-PRIMATES; PROTECTION; ANTIBODY; GORILLAS; PARTICLES; DECLINE; CELLS; ASSAY AB Infectious disease has only recently been recognized as a major threat to the survival of Endangered chimpanzees and Critically Endangered gorillas in the wild. One potentially powerful tool, vaccination, has not been deployed in fighting this disease threat, in good part because of fears about vaccine safety. Here we report on what is, to our knowledge, the first trial in which captive chimpanzees were used to test a vaccine intended for use on wild apes rather than humans. We tested a virus-like particle vaccine against Ebola virus, a leading source of death in wild gorillas and chimpanzees. The vaccine was safe and immunogenic. Captive trials of other vaccines and of methods for vaccine delivery hold great potential as weapons in the fight against wild ape extinction. C1 [Warfield, Kelly L.; Unfer, Robert C.; Vu, Hong; Aman, M. Javad] Integrated BioTherapeut Inc, Gaithersburg, MD 20878 USA. [Goetzmann, Jason E.] Univ Louisiana Lafayette, New Iberia Res Ctr, New Iberia, LA 70562 USA. [Biggins, Julia E.; Kasda, Mary Beth; Olinger, Gene Gerrard, Jr.] US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Walsh, Peter D.] Univ Cambridge, Dept Archael & Anthropol, Cambridge CB2 3QG, England. RP Walsh, PD (reprint author), Univ Cambridge, Dept Archael & Anthropol, Cambridge CB2 3QG, England. EM pdw36@cam.ac.uk FU Paul G. Allen Family Foundation FX We thank the New Iberia Research Center for a nocost extension to our research, Kansas State University for administrative assistance, and The Paul G. Allen Family Foundation for financial support. NR 33 TC 12 Z9 14 U1 4 U2 75 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD JUN 17 PY 2014 VL 111 IS 24 BP 8873 EP 8876 DI 10.1073/pnas.1316902111 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AI9XO UT WOS:000337300100045 PM 24912183 ER PT J AU Titus, J Filfili, C Hilliard, JK Ward, JA Perera, AGU AF Titus, Jitto Filfili, Chadi Hilliard, Julia K. Ward, John A. Perera, A. G. Unil TI Early detection of cell activation events by means of attenuated total reflection Fourier transform infrared spectroscopy SO APPLIED PHYSICS LETTERS LA English DT Article ID FTIR SPECTROSCOPY; TRANSCRIPTION; INFECTION AB Activation of Jurkat T-cells in culture following treatment with anti-CD3 (Cluster of Differentiation 3) antibody is detectable by interrogating the treated T-cells using the Attenuated Total Reflection-Fourier Transform Infrared (ATR-FTIR) Spectroscopy technique. Cell activation was detected within 75 min after the cells encountered specific immunoglobulin molecules. Spectral markers noted following ligation of the CD3 receptor with anti CD3 antibody provides proof-of-concept that ATR-FTIR spectroscopy is a sensitive measure of molecular events subsequent to cells interacting with anti-CD3 Immunoglobulin G. The resultant ligation of the CD3 receptor results in the initiation of well defined, specific signaling pathways that parallel the measurable molecular events detected using ATR-FTIR. Paired t-test with post-hoc Bonferroni corrections for multiple comparisons has resulted in the identification of statistically significant spectral markers (p < 0.02) at 1367 and 1358 cm(-1). Together, these data demonstrate that early treatment-specific cellular events can be measured by ATR-FTIR and that this technique can be used to identify specific agents via the responses of the cell biosensor at different time points postexposure. (C) 2014 AIP Publishing LLC. C1 [Titus, Jitto; Perera, A. G. Unil] GSU, Optoelect Lab, Dept Phys & Astron, Atlanta, GA 30303 USA. [Filfili, Chadi; Hilliard, Julia K.] GSU, Dept Biol, Viral Immunol Ctr, Atlanta, GA 30303 USA. [Ward, John A.] Brooke Army Med Ctr, Dept Clin Invest, San Antonio, TX 78234 USA. RP Filfili, C (reprint author), GSU, Dept Biol, Viral Immunol Ctr, Atlanta, GA 30303 USA. EM uperera@gsu.edu FU Molecular Basis of Disease Area of Focus, Georgia State University, Atlanta, GA; Georgia Research Alliance, AFOSR [55655-EL-DURIP]; DOD [W81XWH-06-1-0795] FX This work was supported in part by the Molecular Basis of Disease Area of Focus, Georgia State University, Atlanta, GA 30303, Georgia Research Alliance, AFOSR: 55655-EL-DURIP and DOD: W81XWH-06-1-0795. NR 19 TC 1 Z9 1 U1 1 U2 12 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUN 16 PY 2014 VL 104 IS 24 AR 243705 DI 10.1063/1.4885081 PG 4 WC Physics, Applied SC Physics GA AJ7XQ UT WOS:000337915000114 ER PT J AU Arun, P Wilder, D Edwards, E Wang, Y Gist, I Long, JB AF Arun, P. Wilder, D. Edwards, E. Wang, Y. Gist, I. Long, J. B. TI BLAST EXPOSURE PHOSPHORYLATES TAU PREFERENTIALLY AT SERINE396, WHICH CAN TRIGGER ALZHEIMER'S-LIKE PATHOLOGY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 32nd Annual National Neurotrauma Symposium CY JUN 29-JUL 02, 2014 CL San Francisco, CA DE Alzheimer's disease; Alzheimer's-like pathology; blast exposure; traumatic brain injury C1 [Arun, P.; Wilder, D.; Edwards, E.; Wang, Y.; Gist, I.; Long, J. B.] Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2014 VL 31 IS 12 MA B5-05 BP A72 EP A72 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AK5DC UT WOS:000338443600193 ER PT J AU Barazanji, K Mayer, A Kinsler, R Wanner, I Matchett, A Rahmatalla, S Wilder, D Kwon, B Cripton, P Chambers, P Reynolds, D AF Barazanji, K. Mayer, A. Kinsler, R. Wanner, I. Matchett, A. Rahmatalla, S. Wilder, D. Kwon, B. Cripton, P. Chambers, P. Reynolds, D. TI VIBRATION EXPOSURE LIMITS FOR NEUROTRAUMA PATIENTS DURING MEDICAL TRANSPORT: OVERVIEW SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 32nd Annual National Neurotrauma Symposium CY JUN 29-JUL 02, 2014 CL San Francisco, CA DE immobilization; medical transport; vibration C1 [Barazanji, K.; Kinsler, R.] US Army Aeromed Res Lab, Ft Rucker, AL USA. [Mayer, A.; Matchett, A.] Lovelace Resp Res Inst, Albuquerque, NM USA. [Wanner, I.] Univ Calif Los Angeles, Los Angeles, CA USA. [Rahmatalla, S.; Wilder, D.] Univ Iowa, Iowa City, IA USA. [Kwon, B.; Cripton, P.] Univ British Columbia, Vancouver, WA USA. [Chambers, P.] Mkt Assessment Inc, Sterling, VA USA. [Reynolds, D.] Univ Nevada, Las Vegas, NV 89154 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2014 VL 31 IS 12 MA OC4-01 BP A13 EP A13 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AK5DC UT WOS:000338443600031 ER PT J AU Boutte, AM Mountney, A Johnson, DW Yarnell, A Tortella, FC Dave, JR Shear, DA Schmid, KE AF Boutte, A. M. Mountney, A. Johnson, D. W. Yarnell, A. Tortella, F. C. Dave, J. R. Shear, D. A. Schmid, K. E. TI DELAYED CONSCIOUSNESS, SENSORY-MOTOR DEFICITS, AND GFAP LEVELS IN REPEATED CONCUSSIVE IMPACT SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 32nd Annual National Neurotrauma Symposium CY JUN 29-JUL 02, 2014 CL San Francisco, CA DE concussion; GFAP; mild TBI; serum C1 [Boutte, A. M.; Mountney, A.; Johnson, D. W.; Yarnell, A.; Tortella, F. C.; Dave, J. R.; Shear, D. A.; Schmid, K. E.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2014 VL 31 IS 12 MA A4-02 BP A37 EP A37 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AK5DC UT WOS:000338443600096 ER PT J AU Brophy, GM Contaifer, D Mohammed, BM White, NJ Newton, JC Martin, EJ Pusateri, AE Ward, KR Brophy, DF AF Brophy, G. M. Contaifer, D. Mohammed, B. M. White, N. J. Newton, J. C. Martin, E. J. Pusateri, A. E. Ward, K. R. Brophy, D. F. TI MULTIMODALITY MONITORING OF PLATELET FUNCTION IN TRAUMATIC BRAIN INJURY PATIENTS WITH TRAUMA INDUCED COAGULOPATHY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 32nd Annual National Neurotrauma Symposium CY JUN 29-JUL 02, 2014 CL San Francisco, CA DE coagulation; platelet function C1 [Brophy, G. M.; Contaifer, D.; Mohammed, B. M.; White, N. J.; Newton, J. C.; Martin, E. J.; Brophy, D. F.] Virginia Commonwealth Univ, Richmond, VA 23284 USA. Puget Sound Blood Ctr, Seattle, WA 98104 USA. [Pusateri, A. E.] US Army Med Res & Mat Command, Ft Detrick, MD USA. [Ward, K. R.] Univ Michigan, Ann Arbor, MI 48109 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2014 VL 31 IS 12 MA A1-08 BP A19 EP A19 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AK5DC UT WOS:000338443600047 ER PT J AU Cartagena, CM Rammelkamp, Z Phillips, KL Tortella, FC Schmid, KE AF Cartagena, C. M. Rammelkamp, Z. Phillips, K. L. Tortella, F. C. Schmid, K. E. TI PROLONGED INCREASES IN 22 KDA TAU FRAGMENT FOLLOWING PENETRATING TBI SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 32nd Annual National Neurotrauma Symposium CY JUN 29-JUL 02, 2014 CL San Francisco, CA DE neurodegeneration; PBBI; severe TBI; tau C1 [Cartagena, C. M.; Rammelkamp, Z.; Phillips, K. L.; Tortella, F. C.; Schmid, K. E.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2014 VL 31 IS 12 MA B5-06 BP A72 EP A72 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AK5DC UT WOS:000338443600194 ER PT J AU Caudle, KL Shear, DA Pedersen, R Sun, J Flerlage, W Faden, J Mountney, A Schmid, KE Tortella, FC Lu, XC AF Caudle, K. L. Shear, D. A. Pedersen, R. Sun, J. Flerlage, W. Faden, J. Mountney, A. Schmid, K. E. Tortella, F. C. Lu, X. C. TI NEUROPROTECTIVE EFFECTS OF LEVETIRACETAM REQUIRES EXTENDED TREATMENT IN A RAT MODEL OF PENETRATING BALLISTIC-LIKE BRAIN INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 32nd Annual National Neurotrauma Symposium CY JUN 29-JUL 02, 2014 CL San Francisco, CA DE Keppra; levetiracetam; traumatic brain injury TBI C1 [Caudle, K. L.; Shear, D. A.; Pedersen, R.; Sun, J.; Flerlage, W.; Faden, J.; Mountney, A.; Schmid, K. E.; Tortella, F. C.; Lu, X. C.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2014 VL 31 IS 12 MA C2-10 BP A80 EP A80 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AK5DC UT WOS:000338443600215 ER PT J AU Caudle, KL Pedersen, R Sun, J Flerlage, W Faden, J Mountney, A Schmid, KE Shear, DA Tortella, FC AF Caudle, K. L. Pedersen, R. Sun, J. Flerlage, W. Faden, J. Mountney, A. Schmid, K. E. Shear, D. A. Tortella, F. C. TI EVALUATION OF LEVETIRACETAM IN THE WRAIR PBBI MODEL: STUDIES FROM THE OPERATION BRAIN TRAUMA THERAPY (OBTT) CONSORTIUM SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 32nd Annual National Neurotrauma Symposium CY JUN 29-JUL 02, 2014 CL San Francisco, CA DE cognitive; Keppra; levetiracetam; motor; operation brain trauma therapy OBTT; traumatic brain injury TBI C1 [Caudle, K. L.; Pedersen, R.; Sun, J.; Flerlage, W.; Faden, J.; Mountney, A.; Schmid, K. E.; Shear, D. A.; Tortella, F. C.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2014 VL 31 IS 12 MA C2-09 BP A79 EP A79 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AK5DC UT WOS:000338443600214 ER PT J AU Chen, ZY Lu, XM Liao, ZL Tortella, F Shear, D AF Chen, Z. Y. Lu, X. M. Liao, Z. L. Tortella, F. Shear, D. TI APPLICATION OF AN ACTIVE AVOIDANCE TASK IN DETECTING COGNITIVE DEFICITS FOLLOWING PENETRATING BALLISTIC-LIKE BRAIN INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 32nd Annual National Neurotrauma Symposium CY JUN 29-JUL 02, 2014 CL San Francisco, CA DE active avoidance task; learning and memory; penetrating ballistic-like brain injury C1 [Chen, Z. Y.; Lu, X. M.; Liao, Z. L.; Tortella, F.; Shear, D.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2014 VL 31 IS 12 MA A5-03 BP A43 EP A43 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AK5DC UT WOS:000338443600114 ER PT J AU DeGraba, TJ Popescu, M Popescu, A Balbir, A Bleiberg, J Riedy, G Balkin, T Merrifield, W AF DeGraba, T. J. Popescu, M. Popescu, A. Balbir, A. Bleiberg, J. Riedy, G. Balkin, T. Merrifield, W. TI RESTING-STATE BRAIN ACTIVITY IN MILD TBI PATIENTS WITH HIGH VERSUS LOW POST-TRAUMATIC STRESS DISORDER SYMPTOM SEVERITY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 32nd Annual National Neurotrauma Symposium CY JUN 29-JUL 02, 2014 CL San Francisco, CA DE magnetoencephalography; MRI; mTBI; PTSD C1 [DeGraba, T. J.; Popescu, M.; Popescu, A.; Balbir, A.; Bleiberg, J.; Riedy, G.; Merrifield, W.] Natl Intrepid Ctr Excellence, Bethesda, MD USA. [Balkin, T.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 14 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2014 VL 31 IS 12 MA A2-10 BP A27 EP A28 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AK5DC UT WOS:000338443600071 ER PT J AU Deng-Bryant, Y Leung, LY Flerlage, WJ Winter, M Yang, W Tortella, FC Shear, DA AF Deng-Bryant, Y. Leung, L. Y. Flerlage, W. J. Winter, M. Yang, W. Tortella, F. C. Shear, D. A. TI COMPREHENSIVE EVALUATION OF CHRONIC SPATIAL LEARNING AND WORKING MEMORY DEFICITS FOLLOWING CLOSED-HEAD CONCUSSIVE INJURY IN RATS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 32nd Annual National Neurotrauma Symposium CY JUN 29-JUL 02, 2014 CL San Francisco, CA DE chronic effects; concussion; spatial learning; working memory C1 [Deng-Bryant, Y.; Leung, L. Y.; Flerlage, W. J.; Winter, M.; Yang, W.; Tortella, F. C.; Shear, D. A.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2014 VL 31 IS 12 MA D2-15 BP A118 EP A118 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AK5DC UT WOS:000338443600321 ER PT J AU Deng-Bryant, Y Leung, LY Tortella, FC Shear, DA AF Deng-Bryant, Y. Leung, L. Y. Tortella, F. C. Shear, D. A. TI PENETRATING BALLISTIC-LIKE BRAIN INJURY PROMOTES TIME-DEPENDENT CELL PROLIFERATION IN ADULT RAT HIPPOCAMPUS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 32nd Annual National Neurotrauma Symposium CY JUN 29-JUL 02, 2014 CL San Francisco, CA DE cell proliferation; gliogenesis; hippocampus C1 [Deng-Bryant, Y.; Leung, L. Y.; Tortella, F. C.; Shear, D. A.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2014 VL 31 IS 12 MA D2-14 BP A118 EP A118 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AK5DC UT WOS:000338443600320 ER PT J AU Deng-Bryant, Y Caudle, K Leung, LY Winter, M Yang, X Cartagena, C Boutte, A Schmid, K Shear, DA Tortella, FC AF Deng-Bryant, Y. Caudle, K. Leung, L. Y. Winter, M. Yang, X. Cartagena, C. Boutte, A. Schmid, K. Shear, D. A. Tortella, F. C. TI EFFECT OF NNZ-2591 TREATMENT ON AXONAL AND SYNAPTIC PLASTICITY FOLLOWING PENETRATING BALLISTIC-LIKE INJURY IN RATS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 32nd Annual National Neurotrauma Symposium CY JUN 29-JUL 02, 2014 CL San Francisco, CA DE axonal sprouting; diketopiperazine; synaptogenesis C1 [Deng-Bryant, Y.; Caudle, K.; Leung, L. Y.; Winter, M.; Yang, X.; Cartagena, C.; Boutte, A.; Schmid, K.; Shear, D. A.; Tortella, F. C.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2014 VL 31 IS 12 MA D1-08 BP A103 EP A103 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AK5DC UT WOS:000338443600280 ER PT J AU Deng-Bryant, Y Leung, LY Readnower, R Tortella, FC Shear, DA AF Deng-Bryant, Y. Leung, L. Y. Readnower, R. Tortella, F. C. Shear, D. A. TI REGION-SPECIFIC IMPAIRMENT OF CEREBRAL MITOCHONDRIAL BIOENERGETICS FOLLOWING PENETRATING BALLISTIC-LIKE BRAIN INJURY IN RATS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 32nd Annual National Neurotrauma Symposium CY JUN 29-JUL 02, 2014 CL San Francisco, CA DE mitochondrial bioenergetics; penetrating ballistic-like brain injury; respiration C1 [Deng-Bryant, Y.; Leung, L. Y.; Readnower, R.; Tortella, F. C.; Shear, D. A.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2014 VL 31 IS 12 MA C3-15 BP A94 EP A94 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AK5DC UT WOS:000338443600255 ER PT J AU Deng-Bryant, Y Leung, LY Readnower, R Yang, W Shear, DA Tortella, FC AF Deng-Bryant, Y. Leung, L. Y. Readnower, R. Yang, W. Shear, D. A. Tortella, F. C. TI GLOBAL METABOLOMICS PROFILING REVEALS METABOLIC DYSREGULATION, OXIDATIVE STRESS AND NEUROTRANSMISSION ALTERATION AFTER CONCUSSION SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 32nd Annual National Neurotrauma Symposium CY JUN 29-JUL 02, 2014 CL San Francisco, CA DE concussion; glucose metabolism; metabolomics; oxidative stress C1 [Deng-Bryant, Y.; Leung, L. Y.; Readnower, R.; Yang, W.; Shear, D. A.; Tortella, F. C.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2014 VL 31 IS 12 MA OC1-02 BP A10 EP A10 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AK5DC UT WOS:000338443600023 ER PT J AU Johnson, D Casandra, CM Boutte, AM Tortella, FC Dave, JR Schmid, KE AF Johnson, D. Casandra, C. M. Boutte, A. M. Tortella, F. C. Dave, J. R. Schmid, K. E. TI MICRORNA DYSREGULATION OCCURS AT ACUTE TIME POINTS AFTER PENETRATING BALLISTIC-LIKE BRAIN INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 32nd Annual National Neurotrauma Symposium CY JUN 29-JUL 02, 2014 CL San Francisco, CA DE severe TBI C1 [Johnson, D.; Casandra, C. M.; Boutte, A. M.; Tortella, F. C.; Dave, J. R.; Schmid, K. E.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2014 VL 31 IS 12 MA C3-06 BP A91 EP A91 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AK5DC UT WOS:000338443600246 ER PT J AU Kelley, AM Ranes, B Estrada, A Grandizio, CM AF Kelley, A. M. Ranes, B. Estrada, A. Grandizio, C. M. TI EVALUATION OF THE MILITARY FUNCTIONAL ASSESSMENT PROGRAM: ASSESSMENT OF THE CONSTRUCT VALIDITY USING ARCHIVED CLINICAL DATA SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 32nd Annual National Neurotrauma Symposium CY JUN 29-JUL 02, 2014 CL San Francisco, CA DE fitness-for-duty; military; return-to-duty C1 [Kelley, A. M.; Estrada, A.; Grandizio, C. M.] US Army Aeromed Res Lab, Ft Rucker, AL USA. [Ranes, B.] Oak Ridge Inst Sci & Educ, Belcamp, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2014 VL 31 IS 12 MA B1-01 BP A44 EP A45 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AK5DC UT WOS:000338443600118 ER PT J AU Kochanek, PM Bramlett, H Shear, D Dixon, CE Dietrich, WD Poloyac, S Empey, PE Schmid, K Mondello, S Wang, KK Hayes, R Tortella, F AF Kochanek, P. M. Bramlett, H. Shear, D. Dixon, C. E. Dietrich, W. D. Poloyac, S. Empey, P. E. Schmid, K. Mondello, S. Wang, K. K. Hayes, R. Tortella, F. TI MULTICENTER COMPARISON OF FIVE THERAPIES REVEALS THERAPEUTIC POTENTIAL FOR LEVETIRACETAM: OPERATION BRAIN TRAUMA THERAPY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 32nd Annual National Neurotrauma Symposium CY JUN 29-JUL 02, 2014 CL San Francisco, CA DE biomarker; consortium; pre-clinical; therapy C1 [Kochanek, P. M.; Dixon, C. E.; Poloyac, S.; Empey, P. E.] Safar Ctr, Pittsburgh, PA USA. [Kochanek, P. M.; Dixon, C. E.; Poloyac, S.; Empey, P. E.] Univ Pittsburgh, Pittsburgh, PA USA. [Bramlett, H.; Dietrich, W. D.] Univ Miami, Miami, FL USA. [Shear, D.; Schmid, K.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Wang, K. K.] Univ Florida, Gainesville, FL USA. [Mondello, S.] Univ Messina, Messina, Italy. [Hayes, R.] Banyan Biomarkers, Alachua, FL USA. RI Kochanek, Patrick/D-2371-2015 OI Kochanek, Patrick/0000-0002-2627-913X NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2014 VL 31 IS 12 MA D1-14 BP A105 EP A105 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AK5DC UT WOS:000338443600286 ER PT J AU Lawson, BD Kass, SJ Dhillon, K Cho, TH Rupert, AH AF Lawson, B. D. Kass, S. J. Dhillon, K. Cho, T. H. Rupert, A. H. TI IDENTIFICATION OF MILITARY OCCUPATIONS MOST LIKELY TO SUFFER MILD TRAUMATIC BRAIN INJURY (MTBI) AND RELATED SENSORY INJURIES SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 32nd Annual National Neurotrauma Symposium CY JUN 29-JUL 02, 2014 CL San Francisco, CA DE blast injury; fitness-for-duty; mild traumatic brain injury; military brain injury; return-to-duty C1 [Lawson, B. D.; Cho, T. H.; Rupert, A. H.] US Army Aeromed Res Lab, Ft Rucker, AL USA. [Kass, S. J.] Univ W Florida, Pensacola, FL 32514 USA. [Dhillon, K.] 22nd Special Tact Squadron, McChord AFB, WA USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2014 VL 31 IS 12 MA B1-11 BP A48 EP A48 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AK5DC UT WOS:000338443600128 ER PT J AU Lee, SW Gajavelli, S Vaccari, JPD Brand, F Spurlock, M Shear, D Tortella, FC Bullock, MR Keane, RW AF Lee, S. W. Gajavelli, S. Vaccari, de Rivero J. P. Brand, F., III Spurlock, M. Shear, D. Tortella, F. C. Bullock, M. R. Keane, R. W. TI THE INFLAMMASOME IS ACTIVATED IN THE CORTEX OF RATS FOLLOWING PENETRATING BALLISTIC BRAIN INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 32nd Annual National Neurotrauma Symposium CY JUN 29-JUL 02, 2014 CL San Francisco, CA DE ballistic-like; brain injury; penetrating; traumatic C1 [Lee, S. W.; Gajavelli, S.; Vaccari, de Rivero J. P.; Brand, F., III; Spurlock, M.; Bullock, M. R.; Keane, R. W.] Univ Miami, Miller Sch Med, Dept Neurosurg, Miami Project Cure Paralysis, Miami, FL 33136 USA. [Shear, D.; Tortella, F. C.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2014 VL 31 IS 12 MA C3-16 BP A94 EP A95 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AK5DC UT WOS:000338443600256 ER PT J AU Leung, LY Deng-Bryant, Y Flerlage, WJ Winter, M Bustos, F Shear, DA Tortella, FC AF Leung, L. Y. Deng-Bryant, Y. Flerlage, W. J. Winter, M. Bustos, F. Shear, D. A. Tortella, F. C. TI COMBINED HYPOXEMIA & HEMORRHAGIC SHOCK WORSEN MOTOR BUT NOT COGNITIVE FUNCTION AFTER PENETRATING BALLISTIC-LIKE BRAIN INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 32nd Annual National Neurotrauma Symposium CY JUN 29-JUL 02, 2014 CL San Francisco, CA DE cognitive; hemorrhagic shock; hypoxemia; motor; neurobehavior; penetrating ballistic-like brain injury C1 [Leung, L. Y.; Deng-Bryant, Y.; Flerlage, W. J.; Winter, M.; Bustos, F.; Shear, D. A.; Tortella, F. C.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2014 VL 31 IS 12 MA D2-13 BP A117 EP A117 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AK5DC UT WOS:000338443600319 ER PT J AU Leung, LY Deng-Bryant, Y Yang, W Winter, M Tortella, FC Shear, DA AF Leung, L. Y. Deng-Bryant, Y. Yang, W. Winter, M. Tortella, F. C. Shear, D. A. TI REGIONAL AND TEMPORAL HISTOPATHOLOGICAL CHANGES FOLLOWING MILD CONCUSSIVE BRAIN INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 32nd Annual National Neurotrauma Symposium CY JUN 29-JUL 02, 2014 CL San Francisco, CA DE axonal injury; concussion; glial activation; histopathology C1 [Leung, L. Y.; Deng-Bryant, Y.; Yang, W.; Winter, M.; Tortella, F. C.; Shear, D. A.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2014 VL 31 IS 12 MA C3-14 BP A94 EP A94 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AK5DC UT WOS:000338443600254 ER PT J AU Lu, XM Tallarida, R Mountney, A Cao, Y Liao, Z Schmid, KE Shear, DA Tortella, FC AF Lu, X. M. Tallarida, R. Mountney, A. Cao, Y. Liao, Z. Schmid, K. E. Shear, D. A. Tortella, F. C. TI A COMBINATION THERAPY OF PHENYTOIN AND ETHOSUXIMIDE IMPROVED THERAPEUTIC BENEFITS AGAINST POST-TRAUMATIC NONCONVULSIVE SEIZURES SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 32nd Annual National Neurotrauma Symposium CY JUN 29-JUL 02, 2014 CL San Francisco, CA DE anti-seizure combination therapy; ethosuximide; penetrating brain injury; phenytoin C1 [Lu, X. M.; Mountney, A.; Cao, Y.; Liao, Z.; Schmid, K. E.; Shear, D. A.; Tortella, F. C.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Tallarida, R.] Temple Univ, Philadelphia, PA 19122 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2014 VL 31 IS 12 MA C2-04 BP A77 EP A78 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AK5DC UT WOS:000338443600209 ER PT J AU Mondello, S Shear, DA Bramlett, HM Dixon, CE Schmid, K Dietrich, WD Wang, KK Hayes, RL Tortella, FC Kochanek, PM AF Mondello, S. Shear, D. A. Bramlett, H. M. Dixon, C. E. Schmid, K. Dietrich, W. D. Wang, K. K. Hayes, R. L. Tortella, F. C. Kochanek, P. M. TI COMPARISON OF TBI MODELS USING BRAIN DAMAGE MARKERS, AND HISTOLOGICAL AND BEHAVIORAL OUTCOMES IN OPERATION BRAIN TRAUMA THERAPY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 32nd Annual National Neurotrauma Symposium CY JUN 29-JUL 02, 2014 CL San Francisco, CA DE animal model; OBTT; traumatic brain injury C1 [Mondello, S.] Univ Messina, Messina, Italy. [Shear, D. A.; Schmid, K.; Tortella, F. C.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Bramlett, H. M.; Dietrich, W. D.] Univ Miami Miller Sch Med, Miami, FL USA. [Dixon, C. E.; Kochanek, P. M.] Univ Pittsburgh, Pittsburgh, PA USA. [Wang, K. K.] Univ Florida, Gainesville, FL USA. [Hayes, R. L.] Banyan Biomarkers, Alachua, FL USA. RI Kochanek, Patrick/D-2371-2015 OI Kochanek, Patrick/0000-0002-2627-913X NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2014 VL 31 IS 12 MA D2-21 BP A120 EP A120 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AK5DC UT WOS:000338443600327 ER PT J AU Mountney, A Rho, C Yang, W Flerlage, J Yarnell, A Cartagena, C Schmid, K Bliese, P Tortella, FC Shear, DA AF Mountney, A. Rho, C. Yang, W. Flerlage, J. Yarnell, A. Cartagena, C. Schmid, K. Bliese, P. Tortella, F. C. Shear, D. A. TI LONGITUDINAL PROFILE OF SENSORIMOTOR DEFICITS FOLLOWING SINGLE AND REPEATED PROJECTILE CONCUSSIVE INJURY (PCI) SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 32nd Annual National Neurotrauma Symposium CY JUN 29-JUL 02, 2014 CL San Francisco, CA DE gait analysis; mild TBI; motor/balance; neuropathology C1 [Mountney, A.; Rho, C.; Yang, W.; Flerlage, J.; Yarnell, A.; Cartagena, C.; Schmid, K.; Bliese, P.; Tortella, F. C.; Shear, D. A.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2014 VL 31 IS 12 MA D2-17 BP A119 EP A119 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AK5DC UT WOS:000338443600323 ER PT J AU Mountney, A Readnower, R Cunningham, T Pedersen, R Sun, J Flerlage, J Caudle, K Schmid, K Tortella, FC Shear, DA AF Mountney, A. Readnower, R. Cunningham, T. Pedersen, R. Sun, J. Flerlage, J. Caudle, K. Schmid, K. Tortella, F. C. Shear, D. A. TI EVALUATION OF SIMVASTATIN IN THE WRAIR PBBI MODEL: STUDIES FROM THE OPERATION BRAIN TRAUMA THERAPY (OBTT) CONSORTIUM SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 32nd Annual National Neurotrauma Symposium CY JUN 29-JUL 02, 2014 CL San Francisco, CA DE neuroprotection; OBTT; PBBI; simvastatin; TBI C1 [Mountney, A.; Readnower, R.; Cunningham, T.; Pedersen, R.; Sun, J.; Flerlage, J.; Caudle, K.; Schmid, K.; Tortella, F. C.; Shear, D. A.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2014 VL 31 IS 12 MA C2-14 BP A81 EP A81 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AK5DC UT WOS:000338443600219 ER PT J AU Sharrow, KM DeMar, JC Hill, MI Edwards, AA Long, JB Oliver, TG AF Sharrow, K. M. DeMar, J. C. Hill, M., I Edwards, A. A. Long, J. B. Oliver, T. G. TI CHARACTERIZATION OF A BLAST-INDUCED BRAIN AND EYE INJURY MODEL IN RATS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 32nd Annual National Neurotrauma Symposium CY JUN 29-JUL 02, 2014 CL San Francisco, CA DE blast injury; eye injury; TBI; vision processing centers C1 [Sharrow, K. M.; Oliver, T. G.] Walter Reed Army Inst Res, Dept Clin Pharmacol & Translat Med, Silver Spring, MD USA. [DeMar, J. C.; Hill, M., I; Edwards, A. A.; Long, J. B.] Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2014 VL 31 IS 12 MA D2-11 BP A116 EP A117 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AK5DC UT WOS:000338443600317 ER PT J AU Shear, DA Caudle, KL Mountney, A Deng-Bryant, Y Pedersen, R Sun, J Schmid, K Lu, M Tallarida, RJ Tortella, FC AF Shear, D. A. Caudle, K. L. Mountney, A. Deng-Bryant, Y. Pedersen, R. Sun, J. Schmid, K. Lu, M. Tallarida, R. J. Tortella, F. C. TI EVALUATION OF COMBINED ADMINISTRATION OF DEXTROMETHORPHAN AND SIMVASTATIN IN AN EXPERIMENTAL MODEL OF TRAUMATIC BRAIN INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 32nd Annual National Neurotrauma Symposium CY JUN 29-JUL 02, 2014 CL San Francisco, CA DE cognitive; combination therapy; motor; PBBI; TBI C1 [Shear, D. A.; Caudle, K. L.; Mountney, A.; Deng-Bryant, Y.; Pedersen, R.; Sun, J.; Schmid, K.; Lu, M.; Tortella, F. C.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Tallarida, R. J.] Temple Univ, Sch Med, Philadelphia, PA 19122 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2014 VL 31 IS 12 MA D1-09 BP A103 EP A104 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AK5DC UT WOS:000338443600281 ER PT J AU Spurlock, MS Hosein, K Bullock, MR Gajavelli, S Yokobori, S O'Connell-Blaya, M Leung, LY Tortella, FC AF Spurlock, M. S. Hosein, K. Bullock, M. R. Gajavelli, S. Yokobori, S. O'Connell-Blaya, M. Leung, L. Y. Tortella, F. C. TI MULTINEUROTROPHIN EXPRESSING FETAL CELL TRANSPLANT IN PENETRATING BALLISTIC BRAIN INJURY (PBBI) SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 32nd Annual National Neurotrauma Symposium CY JUN 29-JUL 02, 2014 CL San Francisco, CA DE chronic TBI; stem cell C1 [Spurlock, M. S.; Hosein, K.; Bullock, M. R.; Gajavelli, S.; Yokobori, S.; O'Connell-Blaya, M.] Univ Miami, Miller Sch Med, Miami, FL 33136 USA. [Leung, L. Y.; Tortella, F. C.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. [Yokobori, S.] Nippon Med Sch, Dept Emergency & Crit Care Med, Tokyo 113, Japan. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2014 VL 31 IS 12 MA D1-27 BP A110 EP A110 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AK5DC UT WOS:000338443600299 ER PT J AU Wang, Y Wei, Y Tong, LC Arun, P Edwares, AA Oguntagyo, SA Gist, ID Long, JB AF Wang, Y. Wei, Y. Tong, L. C. Arun, P. Edwares, A. A. Oguntagyo, S. A. Gist, I. D. Long, J. B. TI CHARACTERIZATION OF BLAST-INDUCED VESTIBULAR INJURY IN RATS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 32nd Annual National Neurotrauma Symposium CY JUN 29-JUL 02, 2014 CL San Francisco, CA DE blast TBI; inflammation; motor coordination; pathology; vestibular system C1 [Wang, Y.; Wei, Y.; Tong, L. C.; Arun, P.; Edwares, A. A.; Oguntagyo, S. A.; Gist, I. D.; Long, J. B.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2014 VL 31 IS 12 MA D2-02 BP A113 EP A113 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AK5DC UT WOS:000338443600309 ER PT J AU Wei, G Yang, XY Shear, DA Tortella, FC AF Wei, G. Yang, X. Y. Shear, D. A. Tortella, F. C. TI THERAPEUTIC WINDOW FOR SELECTIVE BRAIN COOLING FOLLOWING PENETRATING BALLISTIC-LIKE BRAIN INJURY IN RATS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 32nd Annual National Neurotrauma Symposium CY JUN 29-JUL 02, 2014 CL San Francisco, CA DE function; hypothermia; penetrating brain injury; therapeutic window C1 [Wei, G.; Yang, X. Y.; Shear, D. A.; Tortella, F. C.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUN 15 PY 2014 VL 31 IS 12 MA C2-05 BP A78 EP A78 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AK5DC UT WOS:000338443600210 ER PT J AU Cassetti, MC Thomas, SJ AF Cassetti, M. Cristina Thomas, Stephen J. TI Dengue Human Infection Model: Introduction SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID VACCINE DEVELOPMENT; ANIMAL-MODELS; VIRUS; CHALLENGE; ETIOLOGY; IMMUNITY; FEVER; PHASE C1 [Cassetti, M. Cristina] NIAID, Virol Branch, Bethesda, MD 20892 USA. [Thomas, Stephen J.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD 20910 USA. RP Thomas, SJ (reprint author), Walter Reed Army Inst Res, Viral Dis Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM stephen.j.thomas3.mil@mail.mil NR 27 TC 5 Z9 5 U1 0 U2 6 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD JUN 15 PY 2014 VL 209 SU 2 BP 537 EP 539 DI 10.1093/infdis/jiu061 PG 3 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AI7JG UT WOS:000337063800001 PM 24872393 ER PT J AU Spring, M Polhemus, M Ockenhouse, C AF Spring, Michele Polhemus, Mark Ockenhouse, Christian TI Controlled Human Malaria Infection SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE malaria; challenge; efficacy; clinical trial; mosquito ID FALCIPARUM CIRCUMSPOROZOITE VACCINE; INSTITUTE-OF-RESEARCH; PHASE 2A TRIAL; PLASMODIUM-FALCIPARUM; NAIVE ADULTS; SPOROZOITE CHALLENGE; PROTEIN VACCINE; EFFICACY; SAFETY; IMMUNOGENICITY AB Background. Since 1986, investigators at Walter Reed Army Institute of Research (WRAIR) have been using controlled human malaria challenge (CHMI) in malaria-naive adults in order to define the protective efficacy of a malaria vaccine and thus guide programmatic decisions on vaccine candidates. Adapting this model to the dengue field could provide similar evidential support for a vaccine or therapeutic product. Methods. After completing a vaccine regimen, volunteers are bitten by 5 malaria-infected female Anopheles mosquitoes in a controlled environment. Volunteers are then monitored daily for peripheral parasitemia in a hotel setting with 24-hour access to a nurse and physician. If a single verified parasite is detected, effective antimalarials are promptly administered. Results. The vast majority of the over 1000 volunteers having participated in CHMI clinical studies have done so at US military research centers. Numerous pre-erythrocytic and erythrocytic vaccine candidates have been evaluated safely and without any related serious adverse events using this model, including the soon-to-be licensed RTS, S malaria vaccine. Conclusion. The lessons learned from over 25 years of experience in consistent, careful preparation and execution of the CHMI model at WRAIR can provide a foundation from which the dengue field can begin to develop a rigorous and safe "CHDI" model. C1 [Spring, Michele; Polhemus, Mark; Ockenhouse, Christian] Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Silver Spring, MD USA. RP Spring, M (reprint author), AFRIMS, Dept Immunol & Med, 315-6 Rajivithi rD, Bangkok 10400, Thailand. EM michele.spring@afrims.org FU Military Infectious Disease Research Program; US Army Medical Research and Materiel Activity of the US Medical Research and Materiel Command; National Vaccine Program Office at US Department of Health and Human Services; Malaria Vaccine Development Program at US Agency for International Development; GlaxoSmithKline Biologicals; Program for Appropriate Technology in Health (PATH) Malaria Vaccine Initiative; National Institutes of Health FX Financial support. The CHMI work conducted from 1986 to 2012 was supported by the Military Infectious Disease Research Program and US Army Medical Research and Materiel Activity of the US Medical Research and Materiel Command, National Vaccine Program Office at US Department of Health and Human Services, Malaria Vaccine Development Program at US Agency for International Development, GlaxoSmithKline Biologicals, Program for Appropriate Technology in Health (PATH) Malaria Vaccine Initiative, and the National Institutes of Health. NR 41 TC 19 Z9 19 U1 1 U2 8 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD JUN 15 PY 2014 VL 209 SU 2 BP 540 EP 545 DI 10.1093/infdis/jiu063 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AI7JG UT WOS:000337063800002 PM 24872394 ER PT J AU Eckels, KH AF Eckels, Kenneth H. TI Production and Testing of Dengue Virus Strains Suitable for Human Infection Studies SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE dengue virus strains; human challenge; vaccine efficacy ID HUMAN CHALLENGE; RHESUS-MONKEYS; VACCINE; ATTENUATION; RECOMBINANT; CANDIDATE; MODEL AB Vaccine efficacy can be assessed in human subjects who have received dengue virus (DENV) candidate vaccines. Recent, published studies have been conducted with DENV strains that resulted in a spectrum of clinical disease. DENV-1 and DENV-3 strains were identified that could be used to test for protection against these serotypes. DENV strains that are intended for similar human clinical studies require production and preclinical testing that are the same as vaccines entering Phase 1 human clinical testing. Information on passage history, use of raw materials, testing for adventitious agents, complete characterization (including genetic sequence), and product stability are essential for DENV strain banks intended for human infection studies. C1 [Eckels, Kenneth H.] Walter Reed Army Inst Res, Pilot Bioprod Facil, Silver Spring, MD 20910 USA. RP Eckels, KH (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM kenneth.h.eckels.civ@mail.mil FU US Military Infectious Disease Research Program, US Army Medical Research and Materiel Command (USAMRMC), Fort Detrick, Maryland FX Financial support. This work was supported by the US Military Infectious Disease Research Program, US Army Medical Research and Materiel Command (USAMRMC), Fort Detrick, Maryland. NR 15 TC 1 Z9 1 U1 0 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD JUN 15 PY 2014 VL 209 SU 2 BP 546 EP 548 DI 10.1093/infdis/jiu161 PG 3 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AI7JG UT WOS:000337063800003 PM 24872395 ER PT J AU Mores, CN Christofferson, RC Davidson, SA AF Mores, Christopher N. Christofferson, Rebecca C. Davidson, Silas A. TI The Role of the Mosquito in a Dengue Human Infection Model SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE Infection model; dengue virus; mosquito; allergic response; innate immunity; humoral immunity; dengue model; dengue vaccine ID WEST-NILE-VIRUS; AEDES-AEGYPTI MOSQUITOS; VECTOR COMPETENCE; LABORATORY TRANSMISSION; PLASMODIUM-FALCIPARUM; JAPANESE ENCEPHALITIS; VACCINE DEVELOPMENT; INFORMATION-SYSTEM; INDUCED HEMORRHAGE; ARTHROPOD SALIVA AB Recent efforts to combat the growing global threat of dengue disease, including deployment of phase IIb vaccine trials, has continued to be hindered by uncertainty surrounding equitable immune responses of serotypes, relative viral fitness of vaccine vs naturally occurring strains, and the importance of altered immune environments due to natural delivery routes. Human infection models can significantly improve our understanding of the importance of certain phenotypic characteristics of viral strains, and inform strain selection and trial design. With human models, we can further assess the importance of the natural delivery route of DENV and/or the accompanying mosquito salivary milieu. Accordingly, we discuss the use of mosquitoes in such a human infection model with DENV, identify important considerations, and make preliminary recommendations for deployment of such a mosquito improved DENV human infection model (miDHIM). C1 [Mores, Christopher N.; Christofferson, Rebecca C.] LSU, Sch Vet Med, Dept Pathobiol Sci, Baton Rouge, LA 70803 USA. [Davidson, Silas A.] Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD USA. RP Mores, CN (reprint author), LSU, Sch Vet Med, Dept Pathobiol Sci, Skip Bertman Dr, Baton Rouge, LA 70803 USA. EM cmores@lsu.edu FU NIH/NIGMS [U01GM097661, P20GM103458] FX Financial support. This work was supported by NIH/NIGMS U01GM097661 and NIH/NIGMS P20GM103458. NR 75 TC 6 Z9 6 U1 2 U2 24 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD JUN 15 PY 2014 VL 209 SU 2 BP 571 EP 578 DI 10.1093/infdis/jiu110 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AI7JG UT WOS:000337063800008 PM 24872400 ER PT J AU Zhang, YS Zhu, YB Gupta, A Huang, YY Murray, CK Vrahas, MS Sherwood, ME Baer, DG Hamblin, MR Dai, TH AF Zhang, Yunsong Zhu, Yingbo Gupta, Asheesh Huang, Yingying Murray, Clinton K. Vrahas, Mark S. Sherwood, Margaret E. Baer, David G. Hamblin, Michael R. Dai, Tianhong TI Antimicrobial Blue Light Therapy for Multidrug-Resistant Acinetobacter baumannii Infection in a Mouse Burn Model: Implications for Prophylaxis and Treatment of Combat-related Wound Infections SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE Blue light; Acinetobacter baumannii; burn; infection; multidrug resistance; mouse model ID MRSA IN-VITRO; STAPHYLOCOCCUS-AUREUS; PHOTODYNAMIC THERAPY; VISIBLE-LIGHT; BACTERIA; INACTIVATION; AFGHANISTAN; PORPHYRINS; 405-NM; MICE AB In this study, we investigated the utility of antimicrobial blue light therapy for multidrug-resistant Acinetobacter baumannii infection in a mouse burn model. A bioluminescent clinical isolate of multidrug-resistant A. baumannii was obtained. The susceptibility of A. baumannii to blue light (415 nm)-inactivation was compared in vitro to that of human keratinocytes. Repeated cycles of sublethal inactivation of bacterial by blue light were performed to investigate the potential resistance development of A. baumannii to blue light. A mouse model of third degree burn infected with A. baumannii was developed. A single exposure of blue light was initiated 30 minutes after bacterial inoculation to inactivate A. baumannii in mouse burns. It was found that the multidrug-resistant A. baumannii strain was significantly more susceptible than keratinocytes to blue light inactivation. Transmission electron microscopy revealed blue light-induced ultrastructural damage in A. baumannii cells. Fluorescence spectroscopy suggested that endogenous porphyrins exist in A. baumannii cells. Blue light at an exposure of 55.8 J/cm(2) significantly reduced the bacterial burden in mouse burns. No resistance development to blue light inactivation was observed in A. baumannii after 10 cycles of sublethal inactivation of bacteria. No significant DNA damage was detected in mouse skin by means of a skin TUNEL assay after a blue light exposure of 195 J/cm(2). C1 [Zhang, Yunsong; Zhu, Yingbo; Gupta, Asheesh; Huang, Yingying; Sherwood, Margaret E.; Hamblin, Michael R.; Dai, Tianhong] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA. [Vrahas, Mark S.] Massachusetts Gen Hosp, Dept Orthopaed Surg, Boston, MA 02114 USA. [Zhang, Yunsong; Gupta, Asheesh; Huang, Yingying; Hamblin, Michael R.; Dai, Tianhong] Harvard Univ, Sch Med, Dept Dermatol, Boston, MA 02115 USA. [Hamblin, Michael R.] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA. [Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. [Baer, David G.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Zhang, Yunsong] Jinan Univ, Dept Burn & Plast Surg, Guangzhou Red Cross Hosp, Guangzhou, Guangdong, Peoples R China. [Zhu, Yingbo] Tongji Univ, Sch Med, Shanghai 200092, Peoples R China. [Gupta, Asheesh] Def Inst Physiol & Allied Sci, Delhi, India. RP Dai, TH (reprint author), Massachusetts Gen Hosp, Wellman Ctr Photomed, BAR 404B,55 Fruit St, Boston, MA 02114 USA. EM tdai@mgh.harvard.edu OI Hamblin, Michael/0000-0001-6431-4605 FU Center for Integration of Medicine and Innovative Technology (CIMIT) under a US Army Medical Research Acquisition Activity [13-1033]; COTA/Smith and Nephew [2012-16]; Airlift Research Foundation [109421]; National Institutes of Health [RO1AI050875] FX This work was supported by the Center for Integration of Medicine and Innovative Technology (CIMIT) under a US Army Medical Research Acquisition Activity cooperative agreement (CIMIT no. 13-1033 to T. D.), COTA/Smith and Nephew (grant 2012-16 to T. D.), the Airlift Research Foundation (Extremity Trauma Research Grant 109421 to T. D.), and the National Institutes of Health (grant RO1AI050875 to M. R. H.). NR 34 TC 18 Z9 19 U1 0 U2 31 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD JUN 15 PY 2014 VL 209 IS 12 BP 1963 EP 1971 DI 10.1093/infdis/jit842 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AI7JB UT WOS:000337063100015 PM 24381206 ER PT J AU Touryan, J Apker, G Lance, BJ Kerick, SE Ries, AJ McDowell, K AF Touryan, Jon Apker, Gregory Lance, Brent J. Kerick, Scott E. Ries, Anthony J. McDowell, Kaleb TI Estimating endogenous changes in task performance from EEG SO FRONTIERS IN NEUROSCIENCE LA English DT Article ID INDEPENDENT COMPONENT ANALYSIS; COUPLED COMPUTER VISION; SPECTRAL COMPONENTS; ALPHA OSCILLATIONS; DRIVER SLEEPINESS; FATIGUE; TIME; ATTENTION; SYSTEM; SYNCHRONIZATION AB Brain wave activity is known to correlate with decrements in behavioral performance as individuals enter states of fatigue, boredom, or low alertness.Many BCI technologies are adversely affected by these changes in user state, limiting their application and constraining their use to relatively short temporal epochs where behavioral performance is likely to be stable. Incorporating a passive BCI that detects when the user is performing poorly at a primary task, and adapts accordingly may prove to increase overall user performance. Here, we explore the potential for extending an established method to generate continuous estimates of behavioral performance from ongoing neural activity; evaluating the extended method by applying it to the original task domain, simulated driving; and generalizing the method by applying it to a BCI-relevant perceptual discrimination task. Specifically, we used EEG log power spectra and sequential forward floating selection (SFFS) to estimate endogenous changes in behavior in both a simulated driving task and a perceptual discrimination task. For the driving task the average correlation coefficient between the actual and estimated lane deviation was 0.37 +/- 0.22 (mu +/- s). For the perceptual discrimination task we generated estimates of accuracy, reaction time, and button press duration for each participant. The correlation coefficients between the actual and estimated behavior were similar for these three metrics (accuracy = 0.25 +/- 0.37, reaction time = 0.33 +/- 0.23, button press duration = 0.36 +/- 0.30). These findings illustrate the potential for modeling time-on-task decrements in performance from concurrent measures of neural activity. C1 [Touryan, Jon; Apker, Gregory; Lance, Brent J.; Kerick, Scott E.; Ries, Anthony J.; McDowell, Kaleb] US Army, Res Lab, Human Res Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Touryan, J (reprint author), US Army, Res Lab, Human Res Engn Directorate, RDRL HRS C, Aberdeen Proving Ground, MD 21005 USA. EM jonathan.o.touryan.ctr@mail.mil FU Army Research Laboratory [W911NF-12-2-0019] FX Research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-12-2-0019. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes not with standing any copyright notation herein. The authors would like to thank T. Johnson, M. Cannon, M. Jaswa, C. Manteuffel, and J. Sidman for their help developing the driving simulator. We would also like to thank P. Weber for developing the RSVP display software; L. Gibson and K. Turner for creating the RSVP stimuli; C. Argys, K. Corby and T. Chiappone for running the experiments. NR 64 TC 6 Z9 6 U1 4 U2 15 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1662-453X J9 FRONT NEUROSCI-SWITZ JI Front. Neurosci. PD JUN 13 PY 2014 VL 8 AR 155 DI 10.3389/fnins.2014.00155 PG 17 WC Neurosciences SC Neurosciences & Neurology GA AW8DQ UT WOS:000346491300001 PM 24994968 ER PT J AU Campbell, JE Meledeo, MA Cap, AP AF Campbell, James E. Meledeo, Michael Adam Cap, Andrew P. TI Comparative Response of Platelet fV and Plasma fV to Activated Protein C and Relevance to a Model of Acute Traumatic Coagulopathy SO PLOS ONE LA English DT Article ID TISSUE FACTOR PATHWAY; FACTOR VA INACTIVATION; COAGULATION-FACTOR-V; THROMBIN GENERATION; IN-VITRO; BLOOD-COAGULATION; SEVERE SEPSIS; FACTOR-VIII; RECEPTOR; MECHANISMS AB Background: Acute traumatic coagulopathy (ATC) has been linked to an increase in activated protein C (aPC) from 40 pM in healthy individuals to 175 pM. aPC exerts its activity primarily through cleavage of active coagulation factor Va (fVa). Platelets reportedly possess fVa which is more resistant to aPC cleavage than plasma fVa; this work examines the hypothesis that normal platelets are sufficient to maintain coagulation in the presence of elevated aPC. Methods: Coagulation responses of normal plasma, fV deficient plasma (fVdp), and isolated normal platelets in fVdp were conducted: prothrombin (PT) tests, turbidimetry, and thromboelastography (TEG), including the dose response of aPC on the samples. Results: PT and turbidimetric assays demonstrate that normal plasma is resistant to aPC at doses much higher than those found in ATC. Additionally, an average physiological number of washed normal platelets (200,000 platelets/mm(3)) was sufficient to eliminate the anti-coagulant effects of aPC up to 10 nM, nearly two orders of magnitude above the ATC concentration and even the steady-state pharmacological concentration of human recombinant aPC, as measured by TEG. aPC also demonstrated no significant effect on clot lysis in normal plasma samples with or without platelets. Conclusions: Although platelet fVa shows slightly superior resistance to aPC's effects compared to plasma fVa in static models, neither fVa is sufficiently cleaved in simulations of ATC or pharmacologically-delivered aPC to diminish coagulation parameters. aPC is likely a correlative indicator of ATC or may play a cooperative role with other activity altering products generated in ATC. C1 [Campbell, James E.; Meledeo, Michael Adam; Cap, Andrew P.] JBSA FT Sam Houston, Coagulat & Blood Res Program, US Army Inst Surg Res, Houston, TX 78234 USA. RP Meledeo, MA (reprint author), JBSA FT Sam Houston, Coagulat & Blood Res Program, US Army Inst Surg Res, Houston, TX 78234 USA. EM michael.a.meledeo.vol@mail.mil OI Meledeo, Michael/0000-0001-9958-9115 FU Combat Casualty Care Research Program of the United States Army Medical Research and Materiel Command [B_040_011] FX Funding for this project was provided by the Combat Casualty Care Research Program of the United States Army Medical Research and Materiel Command, proposal designation B_040_011. https://ccc.amedd.army.mil/. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 70 TC 12 Z9 12 U1 0 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUN 12 PY 2014 VL 9 IS 6 AR e99181 DI 10.1371/journal.pone.0099181 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AK8TP UT WOS:000338701300040 PM 24921658 ER PT J AU Steers, NJ Currier, JR Jobe, O Tovanabutra, S Ratto-Kim, S Marovich, MA Kim, JH Michael, NL Alving, CR Rao, M AF Steers, Nicholas J. Currier, Jeffrey R. Jobe, Ousman Tovanabutra, Sodsai Ratto-Kim, Silvia Marovich, Mary A. Kim, Jerome H. Michael, Nelson L. Alving, Carl R. Rao, Mangala TI Designing the epitope flanking regions for optimal generation of CTL epitopes SO VACCINE LA English DT Article DE HIV-1; Gag-p24; Proteasome; CTL-epitope; Synthetic flanking region; Immunogen design ID T-CELL EPITOPES; MEDIATED ANTIGEN PRESENTATION; THIMET OLIGOPEPTIDASE; LYMPHOCYTE RESPONSES; HIV-1 INFECTION; IN-VITRO; PROTEASOME; VIRUS; SEQUENCES; PEPTIDES AB The flanking amino acids that surround epitopes are critical for effective antigen processing and maintenance of epitope integrity. In the present study, the frequency and characteristics of each amino acid that flanked the peptides generated from the proteasomal degradation of three different subtypes of HIV-1 Gag-p24 were determined. Synthetic flanking regions were designed based on the highest and the lowest frequencies of amino acid with the ideal characteristics at positions upstream and downstream of the proteasomal cleavage site. Peptides were synthesized that contained known CD8+ CTL-epitopes from HIV-1 Gag, CMV pp65, and vaccinia proteins HRP-2, and C16, flanked by amino acid sequences specifically designed to either generate or inhibit the known CD8+ CTL-epitopes. As predicted, the known CD8+ CTL-epitopes were effectively generated from the peptides with synthetic flanking regions specifically designed to promote epitope generation in a proteasome-dependent manner. The majority of the proteasome-generated epitopes were cleaved immediately after the C-terminal amino acid of the specific CTL-epitope. The synthetic peptide sequences containing known CD8+ CTL-epitopes with the flanking regions that promote epitope generation were effectively processed and presented to epitope specific CD8+ T-cells resulting in the production of IFN-gamma. These results highlight the importance of flanking regions in promoting efficient antigen processing and presentation. This concept can have important implications in vaccine design and development strategies. Published by Elsevier Ltd. C1 [Steers, Nicholas J.; Currier, Jeffrey R.; Jobe, Ousman; Tovanabutra, Sodsai; Ratto-Kim, Silvia; Marovich, Mary A.; Kim, Jerome H.; Michael, Nelson L.; Alving, Carl R.; Rao, Mangala] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Steers, Nicholas J.; Currier, Jeffrey R.; Jobe, Ousman; Tovanabutra, Sodsai; Ratto-Kim, Silvia] Henry M Jackson Fdn Adv Mil Med, Rockledge, MD 20852 USA. RP Rao, M (reprint author), Walter Reed Army Inst Res, USMHRP, Lab Adjuvant & Antigen Res, 503 Robert Grant Ave,Rm 2A09, Silver Spring, MD 20910 USA. EM mrao@hivresearch.org FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DOD) [W81XWH-07-2-0067] FX This work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD). NR 48 TC 2 Z9 2 U1 2 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD JUN 12 PY 2014 VL 32 IS 28 BP 3509 EP 3516 DI 10.1016/j.vaccine.2014.04.039 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA AL0NC UT WOS:000338822600007 PM 24795226 ER PT J AU Pondo, T Rose, CE Martin, SW Keitel, WA Keyserling, HL Babcock, J Parker, S Jacobson, RM Poland, GA McNeil, MM AF Pondo, Tracy Rose, Charles E., Jr. Martin, Stacey W. Keitel, Wendy A. Keyserling, Harry L. Babcock, Janiine Parker, Scott Jacobson, Robert M. Poland, Gregory A. McNeil, Michael M. TI Evaluation of sex, race, body mass index and pre-vaccination serum progesterone levels and post-vaccination serum anti-anthrax protective immunoglobulin G on injection site adverse events following anthrax vaccine adsorbed (AVA) in the CDC AVA human clinical trial SO VACCINE LA English DT Article DE Anthrax vaccine adsorbed; Anthrax vaccines/adverse events; Sex factors; Race; Body mass index; Immunological response ID IMMUNE-RESPONSES; RANDOMIZED-TRIAL; SAFETY PROFILE; IMMUNOGENICITY; DISABILITY; IMMUNIZATION; PREGNANCY; HORMONES; GENDER; SYSTEM AB Background: Anthrax vaccine adsorbed (AVA) administered intramuscularly (IM) results in fewer adverse events (AEs) than subcutaneous (SQ) administration. Women experience more AEs than men. Antibody response, female hormones, race, and body mass index (BMI) may contribute to increased frequency of reported injection site AEs. Methods: We analyzed data from the CDC AVA human clinical trial. This double blind, randomized, placebo controlled trial enrolled 1563 participants and followed them through 8 injections (AVA or placebo) over a period of 42 months. For the trial's vaccinated cohort (n = 1267), we used multivariable logistic regression to model the effects of study group (SQ or IM), sex, race, study site, BMI, age, and post-vaccination serum anti-PA IgG on occurrence of AEs of any severity grade. Also, in a women-only subset (n = 227), we assessed effect of pre-vaccination serum progesterone level and menstrual phase on AEs. Results: Participants who received SQ injections had significantly higher proportions of itching, redness, swelling, tenderness and warmth compared to the IM study group after adjusting for other risk factors. The proportions of redness, swelling, tenderness and warmth were all significantly lower in blacks vs. non-black participants. We found arm motion limitation, itching, pain, swelling and tenderness were more likely to occur in participants with the highest anti-PA IgG concentrations. In the SQ study group, redness and swelling were more common for obese participants compared to participants who were not overweight. Females had significantly higher proportions of all AEs compared to males. Menstrual phase was not associated with any AEs. Conclusions: Female and non-black participants had a higher proportion of AVA associated AEs and higher anti-PA IgG concentrations. Antibody responses to other vaccines may also vary by sex and race. Further studies may provide better understanding for higher proportions of AEs in women and non-black participants. Published by Elsevier Ltd. C1 [Pondo, Tracy; Rose, Charles E., Jr.; Martin, Stacey W.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Bacterial Dis, Atlanta, GA 30333 USA. [McNeil, Michael M.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Immunizat Safety Off, Atlanta, GA USA. [Keitel, Wendy A.] Baylor Coll Med, Houston, TX 77030 USA. [Keyserling, Harry L.] Emory Univ, Sch Med, Atlanta, GA USA. [Babcock, Janiine] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Washington, DC 20307 USA. [Parker, Scott] Univ Alabama Birmingham, Birmingham, AL USA. [Jacobson, Robert M.; Poland, Gregory A.] Mayo Clin, Rochester, MN USA. RP Pondo, T (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Bacterial Dis, Atlanta, GA 30333 USA. EM dio2@cdc.gov FU CDC FX The protocol for this study was approved by an Institutional Review Board of the Centers for Disease Control and Prevention (CDC). The funding for this study was provided solely by the CDC. NR 44 TC 10 Z9 10 U1 1 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD JUN 12 PY 2014 VL 32 IS 28 BP 3548 EP 3554 DI 10.1016/j.vaccine.2014.04.025 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA AL0NC UT WOS:000338822600012 PM 24768633 ER PT J AU DeCoste, JB Peterson, GW AF DeCoste, Jared B. Peterson, Gregory W. TI Metal-Organic Frameworks for Air Purification of Toxic Chemicals SO CHEMICAL REVIEWS LA English DT Review ID COORDINATIVELY UNSATURATED SITES; ZEOLITIC IMIDAZOLATE FRAMEWORKS; MOF/GRAPHITE OXIDE COMPOSITES; HYDROGEN-SULFIDE ADSORPTION; CU-BTC; REACTIVE ADSORPTION; CARBON-MONOXIDE; XYLENE ISOMERS; WARFARE AGENTS; ZIRCONIUM HYDROXIDE C1 [DeCoste, Jared B.] Leidos Inc, Gunpowder, MD 21010 USA. [Peterson, Gregory W.] US Army Res Dev & Engn Command, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP DeCoste, JB (reprint author), Leidos Inc, POB 68, Gunpowder, MD 21010 USA. EM jared.b.decoste2.ctr@mail.mil; gregory.w.peterson.civ@mail.mil FU Joint Science and Technology Office for Chemical Biological Defense (JSTO-CBD) [BA07PRO104] FX The authors thank the Joint Science and Technology Office for Chemical Biological Defense (JSTO-CBD) for funding this review, under Project Number BA07PRO104, and David Tevault for technical editing. Gas mask photograph in the table of contents and cover graphics courtesy of the U.S. Army. NR 224 TC 177 Z9 177 U1 65 U2 426 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0009-2665 EI 1520-6890 J9 CHEM REV JI Chem. Rev. PD JUN 11 PY 2014 VL 114 IS 11 BP 5695 EP 5727 DI 10.1021/cr4006473 PG 33 WC Chemistry, Multidisciplinary SC Chemistry GA AJ0JJ UT WOS:000337336500003 PM 24750116 ER PT J AU Suleiman, D Padovani, AM Negron, AA Sloan, JM Napadensky, E Crawford, DM AF Suleiman, David Padovani, Agnes M. Negron, Arnaldo A. Sloan, James M. Napadensky, Eugene Crawford, Dawn M. TI Mechanical and Chemical Properties of Poly( styrene- isobutylenestyrene) Block Copolymers: Effect of Sulfonation and Counter Ion Substitution SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article DE elastomers; mechanical properties; nanostructured polymers; properties and characterization; structure-property relations ID METHANOL FUEL-CELLS; X-RAY-SCATTERING; TRIBLOCK COPOLYMER; THERMOGRAVIMETRIC CHARACTERIZATION; ELECTROLYTE MEMBRANES; TRANSPORT-PROPERTIES; EXCHANGE CAPACITIES; IONOMERS; NANOINDENTATION; MORPHOLOGY AB In this study, the mechanical and chemical properties of a series of sulfonated poly(styrene-isobutylene-styrene) (SIBS) block copolymers were evaluated using a combination of nanoindentation, dynamic mechanical analysis (DMA), elemental analysis (EA), Fourier transform infrared spectroscopy (FTIR), water absorption, and small angle X-ray scattering studies (SAXS). The materials properties were characterized as a function of the sulfonation percent in the block copolymers, as well as a result of the counter-ion substitution with Mg2+, Ca2+, and Ba2+. Nanoindentation studies revealed that the elastic modulus (E) and hardness (H) increase with sulfonation up to a certain level, at which point, the effect of water content further hinders any mechanical reinforcement. The incorporation of counter-ions increases E and H, but the results are dependent upon the size of the counter-ion. DMA results showed that the polymer maintained the glass transition temperature (T-g) of the polyisobutylene (PIB) segment (-60 degrees C) regardless of the sulfonation level or counter-ion substituted. However, both the shoulder of the PIB T-g (-30 degrees C), which was probably caused by a Rouse-type motion, as well as the T-g of polystyrene (105 degrees C) disappeared upon sulfonation. Counter-ion substitution increased the storage modulus of the rubbery plateau, which is indicative of a stronger and more thermally stable crosslinked complex formation. Additional unique relaxations were observed with the counter-ions, and could be attributed to the stretching/rotation of the SO bond and the interaction of the cations with the oxygen in the sulfonic group. FTIR results also revealed a unique shifting of the asymmetric SO band when counter-ions were added. (c) 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40344. C1 [Suleiman, David; Padovani, Agnes M.; Negron, Arnaldo A.] Univ Puerto Rico, Dept Chem Engn, Mayaguez, PR 00681 USA. [Padovani, Agnes M.] Univ Puerto Rico, Engn Sci & Mat Dept, Mayaguez, PR 00681 USA. [Sloan, James M.; Napadensky, Eugene; Crawford, Dawn M.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Suleiman, D (reprint author), Univ Puerto Rico, Dept Chem Engn, Mayaguez, PR 00681 USA. EM David.Suleiman@upr.edu FU Department of Defense (DOD) of the United States [W911-NF-11-10486]; National Science Foundation (NSF) [HRD-0833112 (CREST), DMR-0922994 (MRI)] FX This investigation was partially supported by the Department of Defense (DOD) of the United States through grant number W911-NF-11-10486 and the National Science Foundation (NSF) under grants HRD-0833112 (CREST) and DMR-0922994 (MRI). The authors would also like to acknowledge the support of Prof. Danilo C. Pozzo, of the University of Washington, and his research group, especially Pablo De La Iglesia, where the SAXS experiments were conducted (NSF DMR 0817622). Finally, the authors would like to acknowledge Ms. Sonia L. Aviles Barreto for her contributions. NR 36 TC 1 Z9 1 U1 2 U2 59 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0021-8995 EI 1097-4628 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD JUN 5 PY 2014 VL 131 IS 11 AR 40344 DI 10.1002/app.40344 PG 8 WC Polymer Science SC Polymer Science GA AC3AL UT WOS:000332387300044 ER PT J AU Murphy, JR Weiss, WR Fryauff, D Dowler, M Savransky, T Stoyanov, C Muratova, O Lambert, L Orr-Gonzalez, S Zeleski, KL Hinderer, J Fay, MP Joshi, G Gwadz, RW Richie, TL Villasante, EF Richardson, JH Duffy, PE Chen, JY AF Murphy, Jittawadee R. Weiss, Walter R. Fryauff, David Dowler, Megan Savransky, Tatyana Stoyanov, Cristina Muratova, Olga Lambert, Lynn Orr-Gonzalez, Sachy Zeleski, Katie Lynn Hinderer, Jessica Fay, Michael P. Joshi, Gyan Gwadz, Robert W. Richie, Thomas L. Villasante, Eileen Franke Richardson, Jason H. Duffy, Patrick E. Chen, Jingyang TI Using infective mosquitoes to challenge monkeys with Plasmodium knowlesi in malaria vaccine studies SO MALARIA JOURNAL LA English DT Article DE Monkey; Rhesus; Macaca mulatta; Plasmodium knowlesi; Anopheles dirus; Anopheles crascens; Vaccine; Methylparaben; Mosquito; Challenge ID ANOPHELES-BALABACENSIS-BALABACENSIS; BLOOD-STAGE ANTIGENS; RHESUS-MONKEYS; BERGHEI SPOROZOITES; PROTECTION; FALCIPARUM; SURVIVAL; SKIN; TRANSMISSION; MACAQUES AB Background: When rhesus monkeys (Macaca mulatta) are used to test malaria vaccines, animals are often challenged by the intravenous injection of sporozoites. However, natural exposure to malaria comes via mosquito bite, and antibodies can neutralize sporozoites as they traverse the skin. Thus, intravenous injection may not fairly assess humoral immunity from anti-sporozoite malaria vaccines. To better assess malaria vaccines in rhesus, a method to challenge large numbers of monkeys by mosquito bite was developed. Methods: Several species and strains of mosquitoes were tested for their ability to produce Plasmodium knowlesi sporozoites. Donor monkey parasitaemia effects on oocyst and sporozoite numbers and mosquito mortality were documented. Methylparaben added to mosquito feed was tested to improve mosquito survival. To determine the number of bites needed to infect a monkey, animals were exposed to various numbers of P. knowlesi-infected mosquitoes. Finally, P. knowlesi-infected mosquitoes were used to challenge 17 monkeys in a malaria vaccine trial, and the effect of number of infectious bites on monkey parasitaemia was documented. Results: Anopheles dirus, Anopheles crascens, and Anopheles dirus X (a cross between the two species) produced large numbers of P. knowlesi sporozoites. Mosquito survival to day 14, when sporozoites fill the salivary glands, averaged only 32% when donor monkeys had a parasitaemia above 2%. However, when donor monkey parasitaemia was below 2%, mosquitoes survived twice as well and contained ample sporozoites in their salivary glands. Adding methylparaben to sugar solutions did not improve survival of infected mosquitoes. Plasmodium knowlesi was very infectious, with all monkeys developing blood stage infections if one or more infected mosquitoes successfully fed. There was also a dose-response, with monkeys that received higher numbers of infected mosquito bites developing malaria sooner. Conclusions: Anopheles dirus, An. crascens and a cross between these two species all were excellent vectors for P. knowlesi. High donor monkey parasitaemia was associated with poor mosquito survival. A single infected mosquito bite is likely sufficient to infect a monkey with P. knowlesi. It is possible to efficiently challenge large groups of monkeys by mosquito bite, which will be useful for P. knowlesi vaccine studies. C1 [Murphy, Jittawadee R.; Dowler, Megan; Savransky, Tatyana; Richardson, Jason H.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Weiss, Walter R.; Fryauff, David; Richie, Thomas L.; Villasante, Eileen Franke] Naval Med Res Ctr, Silver Spring, MD 20910 USA. [Stoyanov, Cristina; Muratova, Olga; Lambert, Lynn; Orr-Gonzalez, Sachy; Zeleski, Katie Lynn; Hinderer, Jessica; Duffy, Patrick E.; Chen, Jingyang] NIAID, NIH, Lab Malaria Immunol & Vaccinol, Rockville, MD USA. [Fay, Michael P.] NIAID, NIH, Div Clin Res, Biostat Res Branch, Bethesda, MD 20892 USA. [Joshi, Gyan] SAIC Frederick Inc, Frederick Natl Lab Canc Res, Frederick, MD 21702 USA. [Gwadz, Robert W.] NIAID, NIH, Lab Malaria & Vector Res, Rockville, MD USA. RP Weiss, WR (reprint author), Naval Med Res Ctr, Silver Spring, MD 20910 USA. EM walter.weiss@verizon.net OI Fay, Michael P./0000-0002-8643-9625; Richie, Thomas/0000-0002-2946-5456 FU NIH [1R01AI068761-01A2]; PATH/MVI [COL-CRADA 7872]; Malaria Research and Reference Reagent Resource Center [HHSN272201000027C]; Intramural Research Program of NIAID; Naval Medical Research Center by the U.S. Army Medical Research Materiel Command [6000.RAD1.F.A0309] FX We thank Paul Howell, Kevin Lee and Andre Laughinghouse for their help producing mosquitoes for these experiments. Financial support was provided by NIH grant # 1R01AI068761-01A2, PATH/MVI grant # COL-CRADA 7872, Malaria Research and Reference Reagent Resource Center grant HHSN272201000027C, the Intramural Research Program of NIAID, and funds allocated to the Naval Medical Research Center by the U.S. Army Medical Research Materiel Command (work unit 6000.RAD1.F. A0309). The views expressed in this article are those of the author and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, nor the U.S. Government. Title 17 U.S.C. 105 provides that 'Copyright protection under this title is not available for any work of the United States Government.' The experiments reported herein were conducted in compliance with the Animal Welfare Act and in accordance with the principles set forth in the "Guide for the Care and Use of Laboratory Animals," Institute of Laboratory Animals Resources, National Research Council, National Academy Press, 1996. NR 51 TC 3 Z9 3 U1 0 U2 9 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD JUN 3 PY 2014 VL 13 AR 215 DI 10.1186/1475-2875-13-215 PG 11 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AL1PL UT WOS:000338897300004 PM 24893777 ER PT J AU Thomas, C Butler, A Larson, S Medina, V Begonia, M AF Thomas, Catherine Butler, Afrachanna Larson, Steven Medina, Victor Begonia, Maria TI COMPLEXATION OF LEAD BY BERMUDA GRASS ROOT EXUDATES IN AQUEOUS MEDIA SO INTERNATIONAL JOURNAL OF PHYTOREMEDIATION LA English DT Article DE Lead; complexation; Bermuda grass; root exudates ID RHIZOSPHERE AB Exudates produced from Bermuda grass roots were collected in deionized water from sterilized Bermuda grass sod at 3-day intervals over a period of 15days. Exudates were analyzed for total organic carbon, and characterized via Fourier Transform Infrared Spectroscopy. Exudate samples were adjusted to pH values of 4.5, 6.5, and 7.5, amended with lead and quantified for soluble and complexed lead via Inductively Coupled PlasmaOptical Emission Spectrometry. Data obtained from total organic carbon measurements indicated compositional changes in Bermuda grass root exudates as organic carbon concentrations increased over time. Analysis of the infrared spectroscopy data indicated that carboxylic acids and amine functional groups were present in root exudates. Also, the ability of root-exuded compounds to solubilize lead in aqueous media was demonstrated as exudate samples dissolved an average of 60% more lead than deionized water. At pH values 4.5 and 7.5, lead complexation by Bermuda grass root exudates increased with decreasing molecular weight size fractions, while an opposite trend was observed at pH 6.5. Results from this study demonstrated the ability of Bermuda grass root exudates to complex lead in aqueous media. C1 [Thomas, Catherine; Butler, Afrachanna; Larson, Steven; Medina, Victor] US Army Corps Engineers, Engineer Res & Dev Ctr, Environm Lab ERDC EL, Vicksburg, MS USA. [Begonia, Maria] Jackson State Univ, Dept Biol, Jackson, MS USA. RP Thomas, C (reprint author), Engineer Res & Dev Ctr, Environm Lab ERDC EL, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM catherine.c.thomas@usace.army.mil NR 8 TC 0 Z9 0 U1 1 U2 71 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1522-6514 EI 1549-7879 J9 INT J PHYTOREMEDIAT JI Int. J. Phytoremediat. PD JUN 3 PY 2014 VL 16 IS 6 BP 634 EP 640 DI 10.1080/15226514.2013.803023 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA 236IB UT WOS:000325787600008 PM 24912248 ER PT J AU Akhvlediani, T Kurtskhalia, I Mdivani, K Ispireli, M Meskhishvili, T Nikolich, M Bautista, C Rivard, R Garges, E AF Akhvlediani, Tamar Kurtskhalia, Irakli Mdivani, Ketevan Ispireli, Maya Meskhishvili, Tinatin Nikolich, Mikeljon Bautista, Christian Rivard, Robert Garges, Eric TI PREVALENCE OF SELECTED SEXUALLY TRANSMITTED INFECTIONS IN GEORGIA MILITARY PERSONNEL SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Akhvlediani, Tamar] WRAIR USAMRIID Clin Res Unit, Tbilisi, Rep of Georgia. [Kurtskhalia, Irakli; Mdivani, Ketevan; Ispireli, Maya; Meskhishvili, Tinatin] Minist Def Georgia, Mil Hosp, Gori, Rep of Georgia. [Nikolich, Mikeljon; Bautista, Christian; Garges, Eric] Walter Reed Army Inst Res, Silver Spring, MD USA. [Rivard, Robert] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM t_akhvlediani@yahoo.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 92 BP S120 EP S120 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500425 ER PT J AU Garges, E Jordan, N Gaydos, J AF Garges, Eric Jordan, Nikki Gaydos, Joel TI THE CASE FOR CLASSIFYING THE US ARMY AS A VULNERABLE POPULATION SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Garges, Eric] US Army Publ Hlth Command, Silver Spring, MD USA. [Jordan, Nikki] US Army Publ Hlth Command, Apg Ea, MD USA. [Gaydos, Joel] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD USA. EM eric.c.garges.mil@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 100 BP S66 EP S66 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500227 ER PT J AU Garges, E Clark, L Jordan, N Leamer, N Gaydos, J AF Garges, Eric Clark, Leslie Jordan, Nikki Leamer, Nicole Gaydos, Joel TI SYPHILIS AND THE US ARMY, NEW CONCERNS FOR AN OLD DISEASE SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Garges, Eric] US Army Publ Hlth Command, Silver Spring, MD USA. [Clark, Leslie; Gaydos, Joel] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD USA. [Jordan, Nikki] US Army Publ Hlth Command, Apg Ea, MD USA. [Leamer, Nicole] US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA. EM eric.c.garges.mil@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA TP 101 BP S66 EP S67 PG 2 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500228 ER PT J AU Jordan, N Clemmons, N Nowak, G Gaydos, J AF Jordan, Nikki Clemmons, Nakia Nowak, Gosia Gaydos, Joel TI ESTIMATING THE BURDEN OF CHLAMYDIA TRACHOMATIS IN THE US ARMY - USE OF THREE PASSIVE SURVEILLANCE SYSTEMS AND CAPTURE-RECAPTURE METHODS TO IDENTIFY INCIDENT CASES SO SEXUALLY TRANSMITTED DISEASES LA English DT Meeting Abstract CT STD Prevention Conference CY JUN 09-12, 2014 CL Atlanta, GA C1 [Jordan, Nikki; Clemmons, Nakia] US Army Publ Hlth Command, APG EA, Gunpowder, MD USA. [Nowak, Gosia] Navy & Marine Corps Publ Hlth Ctr, Portsmouth, Hants, England. [Gaydos, Joel] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD USA. EM nikki.n.jordan.civ@mail.mil NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2014 VL 41 SU 1 MA WP 122 BP S128 EP S128 PG 1 WC Infectious Diseases SC Infectious Diseases GA CE7WB UT WOS:000352051500455 ER PT J AU Washburn, BE Cisar, PJ DeVault, TL AF Washburn, Brian E. Cisar, Paul J. DeVault, Travis L. TI Wildlife Strikes With Military Rotary-Wing Aircraft During Flight Operations Within the United States SO WILDLIFE SOCIETY BULLETIN LA English DT Article DE airfields; helicopters; military; rotary-wing aircraft; wildlife strikes ID COLLISIONS; AIRPORTS; RANKING; BIRDS; RISK AB Wildlife-aircraft collisions (wildlife strikes) with civilian and military aircraft pose notable risks and economic losses. The 4 military services within the U. S. Department of Defense maintain records regarding wildlife strikes with military aircraft. Although rotary-wing aircraft operations comprise important mission components within all 4 military services, no assessment of wildlife strikes to military rotary-wing aircraft has been conducted. The objectives of this project were to 1) conduct a comprehensive analysis of data available from all military services regarding wildlife strikes with rotary-wing aircraft, and 2) provide recommendations to reduce the frequency and negative impacts of these strikes. We acquired all available wildlife strike records and parsed our database to include only wildlife strikes to military rotary-wing aircraft occurring within the contiguous United States, Alaska, Hawaii, or within near-shore areas along the coasts. We assessed the effects of year, month, time of day, event location (i.e., on-or off-airfield), and wildlife group involved on the frequency of wildlife strikes with rotary-wing aircraft. The frequency of wildlife strikes was highest during autumn (Sept-Nov; 41.6% of all strikes) and lowest during winter (Dec-Feb; 10.4%). Wildlife strikes occurred most often when aircraft were traveling en route (38.3%) or were engaged in terrain flight (28.9%). Raptors and vultures were commonly associated with wildlife strikes that caused damage to aircraft. Wildlife strikes to military rotary-wing aircraft during flight operations within the United States are both costly (averaging US$12,184-$337,281/strike event among the military services) and deadly (2 pilots were killed). Published 2014. This article is a U.S. Government work and is in the public domain in the USA. C1 [Washburn, Brian E.; DeVault, Travis L.] Wildlife Serv, USDA, Anim Plant Hlth Inspect Serv, Natl Wildlife Res Ctr, Sandusky, OH 44870 USA. [Cisar, Paul J.] US Army, Logist Div, Aberdeen Test Ctr, Aberdeen Proving Ground, MD 21005 USA. RP Washburn, BE (reprint author), Wildlife Serv, USDA, Anim Plant Hlth Inspect Serv, Natl Wildlife Res Ctr, 6100 Columbus Ave, Sandusky, OH 44870 USA. EM brian.e.washburn@aphis.usda.gov FU United States Department of Defense (DoD) Legacy Resource Management Program FX We thank the United States Department of Defense (DoD) Legacy Resource Management Program for funding and supporting the execution of this project. We appreciate the encouragement, professional advice, and data access provided by the U.S. Air Force Safety Center Bird-Wildlife Aircraft Strike Hazard (BASH) Team (specifically D. Sullivan and Lt. Tiffany Robertson), the U.S. Navy BASH Team and the Naval Safety Center (specifically M. Klope and Lt. V. Jensen), the U.S. Army Combat Readiness-Safety Center (specifically R. Dickinson and C. Lyle), and the U.S. Coast Guard Safety Center (specifically Lieutenant Commander B. Potter). B. Blackwell, M. Begier, and 2 anonymous reviewers provided helpful comments that improved the manuscript. The content of this manuscript reflects the views of the National Wildlife Research Center and does not necessarily reflect the views of the DoD Legacy Resource Management Program. NR 29 TC 1 Z9 1 U1 2 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1938-5463 J9 WILDLIFE SOC B JI Wildl. Soc. Bull. PD JUN PY 2014 VL 38 IS 2 BP 311 EP 320 DI 10.1002/wsb.409 PG 10 WC Biodiversity Conservation SC Biodiversity & Conservation GA CD9PV UT WOS:000351431200012 ER PT J AU Kamapantula, BK Abdelzaher, A Ghosh, P Mayo, M Perkins, EJ Das, SK AF Kamapantula, Bhanu K. Abdelzaher, Ahmed Ghosh, Preetam Mayo, Michael Perkins, Edward J. Das, Sajal K. TI Leveraging the robustness of genetic networks: a case study on bio-inspired wireless sensor network topologies SO JOURNAL OF AMBIENT INTELLIGENCE AND HUMANIZED COMPUTING LA English DT Article DE Gene regulatory networks; Wireless sensor networks; NS-2; Robustness ID COMPLEX NETWORKS; MOTIFS AB Wireless sensor networks (WSNs) form a critical component in modern computing applications; given their size, ability to process and communicate information, and to sense stimuli, they are a promising part of the Internet of Things. However, they are also plagued by reliability and node failure problems. Here we address these problems by using the Gene Regulatory Networks (GRNs) of the organism Escherichia coli-believed to be robust against signaling disruptions, such as gene failures- to study the transmission properties of randomlygenerated WSNs and transmission structures derived from these genetic networks. Selection of sink nodes is crucial to the performance of these networks; here we introduce four sink-node selection techniques: two motif-based, an attractor based and a highest degree-based approach and perform comprehensive simulations to assess their performance. Specifically, we use NS-2 simulations to evaluate the packet transmission robustness properties of such GRN-derived communication structures as against typical randomly deployed sensor network topologies under varying channel loss models. Packet receipt rates are compared among these networks, which are shown to be higher using GRNs for the communication structure, rather than randomly generated WSNs. We also evaluate the performance of communication structures derived from existing biological network generation models to assess their applicability in providing robust communication. This work paves the way for future development of fault-tolerant and robust WSN deployment and routing algorithms based on the inherent signal transmission robustness properties of the gene regulatory network topologies. C1 [Kamapantula, Bhanu K.; Abdelzaher, Ahmed; Ghosh, Preetam] Virginia Commonwealth Univ, Dept Comp Sci, Richmond, VA 23284 USA. [Mayo, Michael; Perkins, Edward J.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Das, Sajal K.] Univ Texas Arlington, Dept Comp Sci & Engn, Arlington, TX 76019 USA. RP Kamapantula, BK (reprint author), Virginia Commonwealth Univ, Dept Comp Sci, Med Coll Virginia Campus, Richmond, VA 23284 USA. EM kamapantulbk@mymail.vcu.edu; abdelzaheraf@mymail.vcu.edu; pghosh@vcu.edu; Michael.L.Mayo@usace.army.mil; Edward.J.Perkins@usace.army.mil; das@uta.edu FU US Army's Environmental Quality and Installations 6.1 basic research program; [NSF-1143737] FX This work was supported by grant number NSF-1143737, and the US Army's Environmental Quality and Installations 6.1 basic research program. The Chief of Engineers approved this material for publication. NR 28 TC 1 Z9 1 U1 0 U2 5 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1868-5137 EI 1868-5145 J9 J AMB INTEL HUM COMP JI J. Ambient Intell. Humaniz. Comput. PD JUN PY 2014 VL 5 IS 3 SI SI BP 323 EP 339 DI 10.1007/s12652-013-0180-0 PG 17 WC Computer Science, Artificial Intelligence; Computer Science, Information Systems; Telecommunications SC Computer Science; Telecommunications GA CD6ZL UT WOS:000351239900006 ER PT J AU Crete, JE Jones, J Neumeier, R AF Crete, Joan E. Jones, Jenny Neumeier, Robin TI Perplexing Presentation of Pink Breast Milk SO JOGNN-JOURNAL OF OBSTETRIC GYNECOLOGIC AND NEONATAL NURSING LA English DT Meeting Abstract DE postpartum; breastfeeding; infection; Serratia marcescens C1 [Crete, Joan E.; Jones, Jenny; Neumeier, Robin] Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0884-2175 EI 1552-6909 J9 JOGNN-J OBST GYN NEO JI JOGNN PD JUN PY 2014 VL 43 SU 1 SI SI BP S86 EP S86 DI 10.1111/1552-6909.12322 PG 1 WC Nursing; Obstetrics & Gynecology SC Nursing; Obstetrics & Gynecology GA CB9NR UT WOS:000349959000119 ER PT J AU Greene, WA Muniz, A Plamper, ML Kaini, RR Wang, HC AF Greene, Whitney A. Muniz, Alberto Plamper, Mark L. Kaini, Ramesh R. Wang, Heuy-Ching TI MicroRNA Expression Profiles of Human iPS Cells, Retinal Pigment Epithelium Derived From iPS, and Fetal Retinal Pigment Epithelium SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS LA English DT Article DE Molecular Biology; Issue 88; microRNA; microarray; human induced-pluripotent stem cells; retinal pigmented epithelium ID PLURIPOTENT STEM-CELLS; RPE; DIFFERENTIATION; TRANSPLANTATION; SECRETION AB The objective of this report is to describe the protocols for comparing the microRNA (miRNA) profiles of human induced-pluripotent stem (iPS) cells, retinal pigment epithelium (RPE) derived from human iPS cells (iPS-RPE), and fetal RPE. The protocols include collection of RNA for analysis by microarray, and the analysis of microarray data to identify miRNAs that are differentially expressed among three cell types. The methods for culture of iPS cells and fetal RPE are explained. The protocol used for differentiation of RPE from human iPS is also described. The RNA extraction technique we describe was selected to allow maximal recovery of very small RNA for use in a miRNA microarray. Finally, cellular pathway and network analysis of microarray data is explained. These techniques will facilitate the comparison of the miRNA profiles of three different cell types. C1 [Greene, Whitney A.; Muniz, Alberto; Plamper, Mark L.; Kaini, Ramesh R.; Wang, Heuy-Ching] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA. RP Wang, HC (reprint author), US Army Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA. EM heuy-ching.h.wang.civ@mail.mil FU U.S. Army Clinical Rehabilitative Medicine Research Program (CRMRP); Military Operational Medicine Research Program (MOMRP) FX This work was supported by U.S. Army Clinical Rehabilitative Medicine Research Program (CRMRP) and Military Operational Medicine Research Program (MOMRP). NR 30 TC 0 Z9 0 U1 0 U2 2 PU JOURNAL OF VISUALIZED EXPERIMENTS PI CAMBRIDGE PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA SN 1940-087X J9 JOVE-J VIS EXP JI J. Vis. Exp. PD JUN PY 2014 IS 88 AR e51589 DI 10.3791/51589 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CB0BQ UT WOS:000349290100046 PM 24999033 ER PT J AU Mitrano, DM Ranville, JF Bednar, A Kazor, K Hering, AS Higgins, CP AF Mitrano, D. M. Ranville, J. F. Bednar, A. Kazor, K. Hering, A. S. Higgins, C. P. TI Tracking dissolution of silver nanoparticles at environmentally relevant concentrations in laboratory, natural, and processed waters using single particle ICP-MS (spICP-MS) SO ENVIRONMENTAL SCIENCE-NANO LA English DT Article ID PLASMA-MASS SPECTROMETRY; ION-RELEASE KINETICS; ENGINEERED NANOPARTICLES; AGGREGATION KINETICS; NANOSILVER; TOXICITY; EXPOSURE; FATE; NANOMATERIALS; SIZE AB The interplay between engineered nanoparticle (ENP) size, surface area, and dissolution rate is critical in predicting ENP environmental behavior. Single particle inductively coupled plasma mass spectrometry (spICP-MS) enables the study of ENPs at dilute (ng L-1) concentrations, facilitating the measurement of ENP behavior in natural systems. Here, the utility of using spICP-MS to quantitatively track the changes in particle diameter over time for 60 and 100 nm Ag ENPs (citrate, tannic acid, and polyvinylpyrrolidone coated) was demonstrated. Short term (<24 h) and intermediate term (1 week) dissolution was examined, with rates for all particles slowing by over an order of magnitude after approximately 24 h. Dissolution was measured primarily as a decrease in particle diameter over time but direct measurement of Ag-(aq)(+) was also completed for the experiments. The importance of water chemistry including chloride, sulfide, and dissolved organic carbon (DOC) was demonstrated, with higher concentrations (1 mg L-1 Cl-, S2- and 20 mg L-1 DOC) resulting in negligible Ag ENP dissolution over 24 h. Slight decreases in particle diameter (<10%) were observed with lower concentrations of these parameters (stoichiometric Cl-, S2- and 2 mg L-1 DOC). Capping agents showed variable effects on dissolution. ENP behavior was also investigated in natural (moderately hard water, creek water) and tap water. Water chemistry was the most significant factor affecting dissolution. Near complete dissolution was observed in chlorinated tap water within several hours. Though modeled as first-order kinetic transformations, the dissolution rates observed suggested the dissolution kinetics might be significantly more complex. Two specific highlights of the benefits of using the spICP-MS technique to measure dissolution in complex samples include 1) the measurement of primary particle size as the metric of dissolution is more direct than attempting to measure the increase of Ag+ in solution and 2) that this is possible even when known sinks for Ag+ exist in the system (e.g. DOC, sediments, biota, sampling container). C1 [Mitrano, D. M.; Ranville, J. F.] Colorado Sch Mines, Dept Chem & Geochem, Golden, CO 80401 USA. [Mitrano, D. M.] Empa Mat Sci & Technol, Technol & Soc Lab, St Gallen, Switzerland. [Bednar, A.] US Army, Engineer Res & Dev Ctr, Vicksburg, MS USA. [Kazor, K.; Hering, A. S.] Colorado Sch Mines, Dept Appl Math & Stat, Golden, CO 80401 USA. [Higgins, C. P.] Colorado Sch Mines, Dept Civil & Environm Engn, Golden, CO 80401 USA. RP Higgins, CP (reprint author), Colorado Sch Mines, Dept Civil & Environm Engn, Golden, CO 80401 USA. EM chiggins@mines.edu RI Higgins, Christopher/B-1836-2010 OI Higgins, Christopher/0000-0001-6220-8673 FU U.S. Army Corps of Engineers [W912HZ-09-P-0163] FX The authors thank the U.S. Army Corps of Engineers (W912HZ-09-P-0163) for funding. Dr. Bernd Nowack and three anonymous reviewers provided valuable comments during manuscript review. NR 59 TC 48 Z9 49 U1 23 U2 106 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2051-8153 EI 2051-8161 J9 ENVIRON-SCI NANO JI Environ.-Sci. Nano PD JUN PY 2014 VL 1 IS 3 BP 248 EP 259 DI 10.1039/c3en00108c PG 12 WC Chemistry, Multidisciplinary; Environmental Sciences; Nanoscience & Nanotechnology SC Chemistry; Environmental Sciences & Ecology; Science & Technology - Other Topics GA AZ1AL UT WOS:000347972700005 ER PT J AU Penn-Barwell, JG Rand, BCC Brown, KV Wenke, JC AF Penn-Barwell, J. G. Rand, B. C. C. Brown, K. V. Wenke, J. C. TI A versatile model of open-fracture infection A CONTAMINATED SEGMENTAL RAT FEMUR DEFECT SO BONE & JOINT RESEARCH LA English DT Article DE Infection; Open fracture; Contamination; Animal-model; Local antibiotics ID OPEN TIBIAL FRACTURES; REDUCE INFECTION; LONG-TERM; WOUNDS; TRAUMA AB Objectives The purpose of this study was to refine an accepted contaminated rat femur defect model to result in an infection rate of approximately 50%. This threshold will allow examination of treatments aimed at reducing infection in open fractures with less risk of type II error. Methods Defects were created in the stablised femurs of anaethetised rats, contaminated with Staphylococcus aureus and then debrided and irrigated six hours later. After 14 days, the bone and implants were harvested for separate microbiological analysis. This basic model was developed in several studies by varying the quantity of bacterial inoculation, introducing various doses of systemic antibiotics with and without local antibiotics. Results The bacterial inoculation associated with a 50% infection rate was established as 1 x 10(2) colony forming units (CFU). With an initial bacterial inoculum of 1 x 10(5) CFU, the dose of systemic antibiotics associated with 50% infection was 5 mg/Kg of cafazolin injected sub-cutaneously every 12 hours, starting at the time of the first debridment and continuing for 72 hours (seven doses). The systemic dose of cafazolin was lowered to 2 mg/Kg when antibiotic polymethyl methacrylate beads were used concurrently with the same amount of bacterial inoculation. Conclusion This model of open fracture infection has been further refined with potential for local and systemic antibiotics. This is a versatile model and with the concepts presented herein, it can be modified to evaluate various emerging therapies and concepts for open fractures. C1 US Army Inst Surg Res, Houston, TX USA. Royal Ctr Def Med, London, England. RP Penn-Barwell, JG (reprint author), Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Trauma & Orthopaed Registrar British Army, Birmingham, W Midlands, England. EM jowan@doctors.net.uk OI rand, ben/0000-0002-9938-2082 NR 15 TC 7 Z9 8 U1 0 U2 3 PU BRITISH EDITORIAL SOC BONE JOINT SURGERY PI LONDON PA 22 BUCKINGHAM STREET, LONDON WC2N 6ET, ENGLAND SN 2046-3758 J9 BONE JOINT RES JI Bone Jt. Res. PD JUN PY 2014 VL 3 IS 6 BP 187 EP 192 DI 10.1302/2046-3758.36.2000293 PG 6 WC Cell & Tissue Engineering; Orthopedics SC Cell Biology; Orthopedics GA AT2KM UT WOS:000344763600003 PM 24926038 ER PT J AU Excler, JL Robb, ML Kim, JH AF Excler, Jean-Louis Robb, Merlin L. Kim, Jerome H. TI HIV-1 vaccines Challenges and new perspectives SO HUMAN VACCINES & IMMUNOTHERAPEUTICS LA English DT Review DE HIV-1; vaccine; correlates; clinical trial; efficacy; public health; licensure ID T-CELL RESPONSES; RECOMBINANT GLYCOPROTEIN-120 VACCINE; NEUTRALIZING ANTIBODY-RESPONSE; HIGHLY PATHOGENIC SIV; ADENOVIRUS SEROTYPE 5; RHESUS-MONKEYS; EFFICACY TRIAL; IMMUNE-RESPONSES; BOOST VACCINE; OF-CONCEPT AB The development of a safe and effective preventive HIV-1 vaccine remains a public health priority. Despite scientific difficulties and disappointing results, HIV-1 vaccine clinical development has, for the first time, established proof-of-concept efficacy against HIV-1 acquisition and identified vaccine-associated immune correlates of risk. The correlate of risk analysis showed that IgG antibodies against the gp120 V2 loop correlated with decreased risk of HIV infection, while Env-specific IgA directly correlated with increased risk. The development of vaccine strategies such as improved envelope proteins formulated with potent adjuvants and DNA and vectors expressing mosaics, or conserved sequences, capable of eliciting greater breadth and depth of potentially relevant immune responses including neutralizing and non-neutralizing antibodies, CD4+ and CD8+ cell-mediated immune responses, mucosal immune responses, and immunological memory, is now proceeding quickly. Additional human efficacy trials combined with other prevention modalities along with sustained funding and international collaboration remain key to bring an HIV-1 vaccine to licensure. C1 [Excler, Jean-Louis; Robb, Merlin L.; Kim, Jerome H.] Walter Reed Army Inst Res, Div Retrovirol, US Mil HIV Res Program, Bethesda, MD 20814 USA. [Excler, Jean-Louis; Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. RP Excler, JL (reprint author), Walter Reed Army Inst Res, Div Retrovirol, US Mil HIV Res Program, Bethesda, MD 20814 USA. EM jexcler@hivresearch.org FU US Army Medical Research and Materiel Command (USA MRMC) [Y1-AI-2642-12]; National Institutes of Allergy and Infectious Diseases [Y1-AI-2642-12]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; US Department of Defense (DOD) [W81XWH-07-2-0067] FX The preparation of this manuscript was supported in part by an Interagency Agreement Y1-AI-2642-12 between the US Army Medical Research and Materiel Command (USA MRMC) and the National Institutes of Allergy and Infectious Diseases. In addition this work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the US Department of Defense (DOD). We are grateful to Stephanie Stevens, U.S. Military HIV Research Program, for helping designing the Figure. NR 148 TC 12 Z9 12 U1 2 U2 11 PU LANDES BIOSCIENCE PI AUSTIN PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA SN 2164-5515 EI 2164-554X J9 HUM VACC IMMUNOTHER JI Human Vaccines Immunother. PD JUN PY 2014 VL 10 IS 6 BP 1734 EP 1746 DI 10.4161/hv.28462 PG 13 WC Biotechnology & Applied Microbiology; Immunology SC Biotechnology & Applied Microbiology; Immunology GA AQ4JV UT WOS:000342763200044 PM 24637946 ER PT J AU Burch, HB Burman, KD Cooper, DS Hennessey, JV AF Burch, Henry B. Burman, Kenneth D. Cooper, David S. Hennessey, James V. TI A 2013 Survey of Clinical Practice Patterns in the Management of Primary Hypothyroidism SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM LA English DT Article ID AMERICAN THYROID ASSOCIATION; THYROTROPIN LEVELS; SUBCLINICAL HYPOTHYROIDISM; PRACTICE GUIDELINE; SERUM THYROTROPIN; DOUBLE-BLIND; PREGNANCY; DISEASE; LEVOTHYROXINE; THERAPY AB Context: In 2012, comprehensive clinical practice guidelines (CPGs) were published regarding the management of hypothyroidism. Objective: We sought to document current practices in the management of primary hypothyroidism and compare these results with recommendations made in the 2012 American Thyroid Association (ATA)/American Association of Clinical Endocrinologists (AACE) hypothyroidism CPGs. In addition, we sought to examine differences in management among international members of U.S.-based endocrine societies and to compare survey results with those obtained from a survey of ATA members performed 12 years earlier. Methods: Clinical members of The Endocrine Society (TES), the ATA, and the AACE were asked to take a web-based survey consisting of 30 questions dealing with testing, treatment, and modulating factors in the management of primary hypothyroidism. Results: In total, 880 respondents completed the survey, including 618 members of TES, 582 AACE members, and 208 ATA members. North American respondents accounted for 67.6%, Latin American 9.7%, European 9.2%, Asia and Oceania 8.1%, and Africa and Middle East 5.5%. Overt hypothyroidism would be treated using L-T-4 alone by 99.2% of respondents; 0.8% would use combination L-T-4 and liothyronine (L-T-3) therapy. Generic L-T-4 would be used by 49.3% and a brand name by 49.9%. The rate of replacement would be gradual (38.5%); an empiric dose, adjusted to achieve target (33.6%); or a calculated full replacement dose (27.8%). A target TSH of 1.0 to 1.9 mU/L was favored in the index case, but 3.0 to 3.9 mU/L was the most commonly selected TSH target for an octogenarian. Persistent hypothyroid symptoms despite achieving a target TSH would prompt testing for other causes by 84.3% of respondents, a referral to primary care by 11.3%, and a change to L-T-4 plus L-T-3 therapy by 3.6%. Evaluation of persistent symptoms would include measurement of T-3 levels by 21.9% of respondents. Subclinical disease with a TSH 5.0 to 10.0 mU/L would be treated without further justification by 21.3% of respondents, or in the presence of positive thyroid peroxidase antibodies (62.3%), hypothyroid symptoms (60.9%), high low-density lipoprotein (52.9%), or goiter (46.6%). The TSH target for a newly pregnant patient was <2.5 mU/L for 96.1% of respondents, with 63.5% preferring a TSH target <1.5 mU/L. Thyroid hormone levels would be checked every 4 weeks during pregnancy by 67.7% and every 8 weeks by an additional 21.4%. A hypothyroid patient with TSH of 0.5 mU/L who becomes pregnant would receive an immediate L-T-4 dose increase by only 36.9% of respondents. Conclusion: The current survey of clinical endocrinologists catalogs current practice patterns in the management of hypothyroidism and demonstrates 1) a nearly exclusive preference for L-T-4 alone as initial therapy, 2) the widespread use of age-specific TSH targets for replacement therapy, 3) a low threshold for treating mild thyroid failure, 4) meticulous attention to TSH targets in the pregnant and prepregnant woman, and 5) a highly variable approach to both the rate and means of restoring euthyroidism for overt disease. Both alignment and focal divergence from recent CPGs are demonstrated. C1 [Burch, Henry B.] Walter Reed Natl Mil Med Ctr, Div Endocrinol, Bethesda, MD 20889 USA. [Burman, Kenneth D.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Burman, Kenneth D.] Washington Hosp Ctr, Endocrinol Sect, Washington, DC 20010 USA. [Burman, Kenneth D.] Georgetown Univ, Med Ctr, Washington, DC 20007 USA. [Cooper, David S.] Johns Hopkins Univ, Sch Med, Div Endocrinol, Baltimore, MD 21205 USA. [Hennessey, James V.] Beth Israel Deaconess Med Ctr, Div Endocrinol, Boston, MA 02215 USA. [Hennessey, James V.] Harvard Univ, Sch Med, Boston, MA 02115 USA. RP Burch, HB (reprint author), US Army, Walter Reed Natl Mil Med Ctr, Div Endocrinol, 8901 Wisconsin Ave,Bldg 19,Room 5053, Bethesda, MD 20889 USA. EM henry.b.burch.mil@health.mil NR 31 TC 11 Z9 11 U1 0 U2 4 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0021-972X EI 1945-7197 J9 J CLIN ENDOCR METAB JI J. Clin. Endocrinol. Metab. PD JUN PY 2014 VL 99 IS 6 BP 2077 EP 2085 DI 10.1210/jc.2014-1046 PG 9 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA AP8PI UT WOS:000342340500049 PM 24527720 ER PT J AU Myers, MA AF Myers, Mary Anne TI Unsexing Petrarch: Charlotte Smith's Lessons in the Sonnet as a Social Medium SO STUDIES IN ROMANTICISM LA English DT Article ID SMITH,CHARLOTTE; 'ELEGIAC-SONNETS' C1 US Mil Acad, West Point, NY 10996 USA. RP Myers, MA (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 50 TC 0 Z9 0 U1 0 U2 0 PU BOSTON UNIV SCHOLARLY PUBL PI BOSTON PA 985 COMMONWEALTH AVE, BOSTON, MA 02215 USA SN 0039-3762 J9 STUD ROMANTICISM JI Stud. Romant. PD SUM PY 2014 VL 53 IS 2 BP 239 EP 263 PG 25 WC Literature SC Literature GA AQ1JO UT WOS:000342537900005 ER PT J AU Conti, G Shay, L Hartzog, W AF Conti, Gregory Shay, Lisa Hartzog, Woodrow TI Deconstructing the Relationship Between Privacy and Security SO IEEE TECHNOLOGY AND SOCIETY MAGAZINE LA English DT Editorial Material C1 [Conti, Gregory; Shay, Lisa] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. [Conti, Gregory] West Points Cyber Res Ctr, West Point, NY USA. [Hartzog, Woodrow] Samford Univ, Cumberland Sch Law, Birmingham, AL USA. [Hartzog, Woodrow] Stanford Law Sch, Ctr Internet & Soc, Stanford, CA USA. RP Conti, G (reprint author), US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. EM gregory.conti@usma.edu; lisa.shay@usma.edu; whartzog@samford.edu NR 9 TC 0 Z9 0 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0278-0097 EI 1937-416X J9 IEEE TECHNOL SOC MAG JI IEEE Technol. Soc. Mag. PD SUM PY 2014 VL 33 IS 2 BP 28 EP 30 DI 10.1109/MTS.2014.2319897 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA AP9KL UT WOS:000342398600010 ER PT J AU Watson, S AF Watson, Samuel TI Frontier Cavalry Trooper: The Letters of Private Eddie Matthews, 1869-1874 SO NEW MEXICO HISTORICAL REVIEW LA English DT Book Review C1 [Watson, Samuel] US Mil Acad, West Point, NY 10996 USA. RP Watson, S (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU UNIV NEW MEXICO PI ALBUQUERQUE PA NEW MEXICO HISTORICAL REVIEW, 1013 MESA VISTA HALL, ALBUQUERQUE, NM 87131-1186 USA SN 0028-6206 J9 NEW MEX HIST REV JI N. M. Hist. Rev. PD SUM PY 2014 VL 89 IS 3 BP 418 EP 419 PG 2 WC History SC History GA AQ2JQ UT WOS:000342612000015 ER PT J AU Bell, JR AF Bell, Jocelyn R. TI THE UNIFORM BOX PRODUCT SO PROCEEDINGS OF THE AMERICAN MATHEMATICAL SOCIETY LA English DT Article AB The uniform box product problem is a weakening of the well-known box product problem, which asks whether box products of certain compact spaces are normal or even paracompact. Using uniformities, a new topology on products is defined between the box and Tychonov topologies. This new product, called the uniform box product, is an extension of the sup metric to powers of compact spaces. We investigate a certain non-metrizable compact space whose uniform box product, in ZFC, is normal, countably paracompact, and collectionwise Hausdorff. C1 US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. RP Bell, JR (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. EM bell.jocelyn@gmail.com NR 9 TC 2 Z9 2 U1 0 U2 0 PU AMER MATHEMATICAL SOC PI PROVIDENCE PA 201 CHARLES ST, PROVIDENCE, RI 02940-2213 USA SN 0002-9939 EI 1088-6826 J9 P AM MATH SOC JI Proc. Amer. Math. Soc. PD JUN PY 2014 VL 142 IS 6 BP 2161 EP 2171 AR PII S0002-9939(2014)11910-1 PG 11 WC Mathematics, Applied; Mathematics SC Mathematics GA AP7YJ UT WOS:000342294200030 ER PT J AU Whitby, MD Carter, TC Britzke, ER Bergeson, SM AF Whitby, Michael D. Carter, Timothy C. Britzke, Eric R. Bergeson, Scott M. TI Evaluation of mobile acoustic techniques for bat population monitoring SO ACTA CHIROPTEROLOGICA LA English DT Article DE active sampling; Anabat; bats; mobile acoustic monitoring; passive sampling; population monitoring; sampling methods ID INSECTIVOROUS BATS; ECHOLOCATION CALLS; UNITED-STATES; HABITAT; COMMUNITIES; DETECTORS; PATTERNS; DESIGN AB Understanding population trends of any species is essential for conservation and management. However, due to difficulty in sampling some species, population status of many bat species is poorly understood. In an effort to resolve this issue, especially in light of emerging threats (e.g., white-nose syndrome and wind energy), a national mobile acoustic monitoring protocol, modeled after European programs, was developed to survey summer bat populations in the United States. While the program calls for conducting transects along roadways, some have suggested that waterways may allow for the gathering of more information. Therefore, we quantified species richness and abundance along car and boat transects to identify the most efficient mobile method. Furthermore, to compare the capabilities of mobile acoustic transects to a more traditional and better understood survey method, we compared species density along transects to stationary acoustic detectors. Using sample-based rarefaction, there was no difference at the 95% confidence level in species density (species/sample) between methods, however stationary points accumulated species more quickly than mobile methods. Of the mobile transect methods, car transects had higher diversity indices than boat transects and tended to show slightly higher species density. While over 1.5 times as many calls were recorded and identified along boat transects, there were no clear advantages of boat transects for monitoring bats except for Myotis grisescens. Additionally, car transects were least time consuming, leading us to conclude that car transects are the most efficient mobile acoustic method to monitor species. Mobile acoustic transects can likely monitor 2-4 species in the Eastern United States, including species with no current population monitoring methodology. C1 [Whitby, Michael D.; Carter, Timothy C.; Bergeson, Scott M.] Ball State Univ, Dept Biol, Muncie, IN 47303 USA. [Britzke, Eric R.] US Army, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Whitby, MD (reprint author), Ball State Univ, Dept Biol, Muncie, IN 47303 USA. EM Michael.Whitby@gmail.com FU Shawnee National Forest; Bat Conservation International FX A special thanks the many field technicians who assisted with the project. Funding was provided by Shawnee National Forest and Bat Conservation International. Comments from two anonymous reviewers greatly improved the manuscript. NR 39 TC 3 Z9 4 U1 11 U2 87 PU MUSEUM & INST ZOOLOGY PAS-POLISH ACAD SCIENCES PI WARSAW PA WILCZA STREET 64, 00-679 WARSAW, POLAND SN 1508-1109 EI 1733-5329 J9 ACTA CHIROPTEROL JI Acta Chiropt. PD JUN PY 2014 VL 16 IS 1 BP 223 EP 230 DI 10.3161/150811014X683417 PG 8 WC Zoology SC Zoology GA AN8LF UT WOS:000340855000020 ER PT J AU Gallaway, MS Lagana-Riordan, C Fink, DS Pecko, JA Barczyk, AN Brannen, SJ Milliken, AM AF Gallaway, M. Shayne Lagana-Riordan, Christine Fink, David S. Pecko, Joseph A. Barczyk, Amanda N. Brannen, Stephen J. Milliken, Amy M. TI An Epidemiological Assessment of Reintegration and Behavioral Health Risk at Joint Base Lewis-McCord, Washington SO MILITARY MEDICINE LA English DT Article ID MENTAL-HEALTH; POSTTRAUMATIC GROWTH; SUBSTANCE-ABUSE; ARMY SOLDIERS; STIGMA; SUICIDE; CARE; ASSOCIATION; PREVENTION; SYMPTOMS AB Soldiers from a brigade at Joint Base Lewis-McChord, Washington, were alleged to have committed numerous crimes, including murder of civilians, during a recent deployment. This study was done to assist the command with (1) analyzing the climate and challenges facing redeploying Soldiers; (2) assessing behavioral risk at both individual and unit levels through targeted reintegration screening; and (3) recommending mitigating strategies to enhance current reintegration processes and reduce the level of high-risk behavior among Soldiers following deployment. The findings from this public health investigation suggest levels of risk and major areas of concern during the redeployment period varied across battalions within the brigade and that risk stratification postdeployment was not correlated with discernible differences in predeployment indicators. Acts of violence were limited to the deployment and immediate postdeployment periods and were allegedly perpetrated by a very small number of Soldiers. C1 [Gallaway, M. Shayne; Lagana-Riordan, Christine; Fink, David S.; Pecko, Joseph A.; Barczyk, Amanda N.; Brannen, Stephen J.; Milliken, Amy M.] US Army, Inst Publ Hlth, Behav & Social Hlth Outcomes Program, Gunpowder, MD 21010 USA. RP Gallaway, MS (reprint author), US Army, Inst Publ Hlth, Behav & Social Hlth Outcomes Program, 5158 Blackhawk Rd,Bldg E-1570, Gunpowder, MD 21010 USA. NR 35 TC 0 Z9 0 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUN PY 2014 VL 179 IS 6 BP 594 EP 601 DI 10.7205/MILMED-D-13-00340 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UM UT WOS:000340806500002 PM 24902124 ER PT J AU Galvagno, SM Dubose, JJ Grissom, TE Fang, R Smith, R Bebarta, VS Shackelford, S Scalea, TM AF Galvagno, Samuel M. Dubose, Joseph J. Grissom, Thomas E. Fang, Raymond Smith, Richard Bebarta, Vikhyat S. Shackelford, Stacy Scalea, Thomas M. TI The Epidemiology of Critical Care Air Transport Team Operations in Contemporary Warfare SO MILITARY MEDICINE LA English DT Article ID SEVERE LUNG INJURY; RESCUE TEAM; MILITARY; FORCE; US AB Critical Care Air Transport Teams (CCATTs) have evolved as a vital component of the U.S. Air Force's aeromedical evacuation system. Previous epidemiological research in this area is limited. The objective of this commentary is to highlight the importance of obtaining robust epidemiological data regarding patients transported by CCATTs. A limited epidemiological analysis was performed to describe CCATT patients transported during Operation Enduring Freedom and the waning months of Operation Iraqi Freedom. CCATT transports for the calendar year 2011 were examined as recorded in the U.S. Transportation Command Regulating and Command and Control (C2) Evacuation System database. As many as 290 CCATT primary patient transport records were reviewed. Of these, 58.6% of patients had multiple injuries, 15.9% of patients had traumatic brain injury, 7% had acute coronary syndromes, and 24.8% of all transports were for nonbattle-related injuries. The most common International Classification of Disease, 9th Edition, Clinical Modification coded injury was bilateral lower extremity amputation (40%). Explosive blasts were the top mechanism of injury for patients requiring CCAT. The distribution of injuries and illnesses requiring CCAT appear to have changed compared to previous conventional conflicts. Understanding the epidemiology of casualties evacuated by CCATT during modern warfare is a prerequisite for the development of effective predeployment training to ensure optimal outcomes for critically ill and injured warriors. C1 [Galvagno, Samuel M.; Grissom, Thomas E.] Univ Maryland, Sch Med, Ctr Shock Trauma, Dept Anesthesiol,Div Trauma Anesthesiol,Program T, Baltimore, MD 21201 USA. [Galvagno, Samuel M.; Grissom, Thomas E.] Univ Maryland, Sch Med, Ctr Shock Trauma, Dept Anesthesiol,Div Crit Care Med,Program Trauma, Baltimore, MD 21201 USA. [Dubose, Joseph J.; Shackelford, Stacy] Univ Maryland, Sch Med, Ctr Shock Trauma, Program Trauma, Baltimore, MD 21201 USA. [Dubose, Joseph J.; Fang, Raymond; Shackelford, Stacy] US Air Force, CSTARS, Baltimore, MD 21201 USA. [Smith, Richard] Air Univ, Maxwell Air Force Base, Montgomery, AL 36112 USA. [Bebarta, Vikhyat S.] US Army, Inst Surg Res, Route Care Res Ctr, Ft Sam Houston, TX 78234 USA. RP Galvagno, SM (reprint author), Univ Maryland, Sch Med, Ctr Shock Trauma, Dept Anesthesiol,Div Trauma Anesthesiol,Program T, T1R83,22 South Greene St, Baltimore, MD 21201 USA. RI bebarta, vikhyat/K-3476-2015 NR 21 TC 3 Z9 3 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUN PY 2014 VL 179 IS 6 BP 612 EP 618 DI 10.7205/MlLMED-D-13-00474 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UM UT WOS:000340806500005 PM 24902127 ER PT J AU Maruta, J Heaton, KJ Mau, AL Ghajar, J AF Maruta, Jun Heaton, Kristin J. Mau, Alexis L. Ghajar, Jamshid TI Predictive Visual Tracking: Specificity in Mild Traumatic Brain Injury and Sleep Deprivation SO MILITARY MEDICINE LA English DT Article ID PURSUIT EYE-MOVEMENTS; SMOOTH-PURSUIT; ATTENTION; SYNCHRONIZATION AB We tested whether reduced cognitive function associated with mild traumatic brain injury (mTBI) and sleep deprivation can be detected and distinguished using indices of predictive visual tracking. A circular visual tracking test was given to 13 patients with acute mTBI (recruited within 2 weeks of injury), 127 normal control subjects, and 43 healthy subjects who were fatigued by 26-hour sleep deprivation. Eye movement was monitored with video-oculography. In the mTBI-related portion of the study, visual tracking performance of acute mTBI patients was significantly worse than normal subjects (p < 0.001). In the sleep-deprivation-related portion of the study, no change was detected between the two baseline measures separated by 2 to 3 weeks, but the 26-hour sleep deprivation significantly degraded the visual tracking performance (p < 0.001). The mTBI subjects had substantially worse visual tracking than sleep-deprived subjects that could also be identified with different visual tracking indices, indicating possible different neurophysiological mechanisms. Results suggest that cognitive, impairment associated with mTBI and fatigue may be triaged with the aid of visual tracking measures. C1 [Maruta, Jun; Ghajar, Jamshid] Brain Trauma Fdn, World Trade Ctr 7, New York, NY 10007 USA. [Heaton, Kristin J.; Mau, Alexis L.] US Army, Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA. [Heaton, Kristin J.; Mau, Alexis L.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02118 USA. [Ghajar, Jamshid] Stanford Univ, Med Ctr, Dept Neurosurg, Stanford, CA 94305 USA. RP Maruta, J (reprint author), Brain Trauma Fdn, World Trade Ctr 7, 34th Floor,250 Greenwich St, New York, NY 10007 USA. OI Maruta, Jun/0000-0002-5054-6605 FU CDMRP [W81XWH-08-2-0646]; USAMRMC [W81XWH-08-1-0021]; James S. McDonnell Foundation FX This work was supported by CDMRP W81XWH-08-2-0646, USAMRMC W81XWH-08-1-0021, and James S. McDonnell Foundation. NR 18 TC 5 Z9 5 U1 3 U2 10 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUN PY 2014 VL 179 IS 6 BP 619 EP 625 DI 10.7205/MILMED-D-13-00420 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UM UT WOS:000340806500006 PM 24902128 ER PT J AU Mooney, SR Horton, PA Trakowski, JH Lenard, JH Barron, MR Nave, PV Gautreaux, MS Lott, HD AF Mooney, Scott R. Horton, Philip A. Trakowski, John H., Jr. Lenard, Janet H. Barron, Mark R. Nave, Peggy V. Gautreaux, Melissa S. Lott, Heather D. TI Military Inpatient Residential Treatment of Substance Abuse Disorders: The Eisenhower Army Medical Center Experience SO MILITARY MEDICINE LA English DT Article ID VETERANS AB Opened in 2009, the Dwight D. Eisenhower Army Medical Center Inpatient Residential Treatment Facility (RTF) is the largest and most well-established inpatient substance use disorder treatment facility in the Department of Defense. The RTF is a 28-day inpatient treatment program that employs evidence-based practices and is based on Alcoholics/Narcotics Anonymous principles that are incorporated with a hybrid of military daily structure regime including early morning physical training. Family involvement is encouraged. The RTF is staffed by a multidisciplinary team specializing in addictions and admits Active/Activated Service Members (SMs) from all Service branches, typically those who have failed other military/civilian substance use disorder programs. Eighty-seven percent of SMs referred to the program successfully commenced, with continuous sobriety observed in over half of SMs 6 months later, and 1 year relapse rates comparable to other alcohol treatment programs. Limitations of our program evaluation efforts, lessons learned, and recommendations for the way ahead are shared. C1 [Mooney, Scott R.; Horton, Philip A.; Trakowski, John H., Jr.; Barron, Mark R.; Nave, Peggy V.; Gautreaux, Melissa S.; Lott, Heather D.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA. RP Mooney, SR (reprint author), Dwight D Eisenhower Army Med Ctr, 300 E Hosp Rd, Ft Gordon, GA 30905 USA. NR 15 TC 0 Z9 0 U1 0 U2 6 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUN PY 2014 VL 179 IS 6 BP 674 EP 678 DI 10.7205/MILMED-D-13-00308 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UM UT WOS:000340806500014 PM 24902136 ER PT J AU Chae, JJ Mulreany, DG Quo, QY Lu, QZ Choi, JS Strehin, L Espinoza, FA Schein, O Trexler, MM Bower, KS Elisseeff, JH AF Chae, Jemin J. Mulreany, Daniel G. Quo, Qiongyu Lu, Qiaozhi Choi, Joseph S. Strehin, Lossif Espinoza, Freddy A. Schein, Oliver Trexler, Morgana M. Bower, Kraig S. Elisseeff, Jennifer H. TI Application of a Collagen-Based Membrane and Chondroitin Sulfate-Based Hydrogel Adhesive for the Potential Repair of Severe Ocular Surface Injuries SO MILITARY MEDICINE LA English DT Article ID NONTRAUMATIC CORNEAL PERFORATION; TECTONIC DRAPE PATCH; AMNIOTIC MEMBRANE; CYANOACRYLATE GLUE; VITRIGEL MEMBRANES; TISSUE ADHESIVE; FIBRIN GLUE; EYE; MANAGEMENT; TRAUMA AB This study was performed to evaluate the potential of a chondroitin sulfate-polyethylene glycol (CS-PEG) adhesive and collagen-based membrane (collagen vitrigel, CV) combination as a method to treat penetrating ocular injuries on the battlefield and to improve this method with two technologies: an antibiotic releasing CS-PEG adhesive and a corneal shaped CV. Burst testing using porcine cadaveric eyes, high-performance liquid chromatography, the Kirby-Bauer bacterial inhibition test, and CV implantations on the live and cadaveric rabbit eyes were performed. The ocular burst test showed CS-PEG adhesive could successfully repair 5-mm to 6-mm length wounds in the corneal and corneoscleral regions but would require CS-PEG + CV to treat larger wounds similar to those seen on the battlefield. In addition, high performance liquid chromatography and the Kirby-Bauer bacterial inhibition test presented evidence suggesting the vancomycin incorporated CS-PEG could inhibit Staphylococcus infection for 9 days. Furthermore, the curved CV showed an advantage by matching the corneal contour without any wrinkle formation. Although this pilot study showed a limited range of possible applications, we demonstrated that the combination of CS-PEG adhesive + CV is a promising method and the 2 technologies improve their applicability to the special demands of the battlefield. C1 [Chae, Jemin J.; Mulreany, Daniel G.; Quo, Qiongyu; Lu, Qiaozhi; Choi, Joseph S.; Strehin, Lossif; Espinoza, Freddy A.; Elisseeff, Jennifer H.] Johns Hopkins Univ, Wilmer Eye Inst, Translat Tissue Engn Ctr, Baltimore, MD 21287 USA. [Chae, Jemin J.; Mulreany, Daniel G.; Quo, Qiongyu; Lu, Qiaozhi; Choi, Joseph S.; Strehin, Lossif; Espinoza, Freddy A.; Elisseeff, Jennifer H.] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21287 USA. [Schein, Oliver; Bower, Kraig S.; Elisseeff, Jennifer H.] Johns Hopkins Univ, Dept Ophthalmol, Baltimore, MD 21287 USA. [Trexler, Morgana M.] Johns Hopkins Univ, Appl Phys Lab, Res & Exploratory Dev Dept, Laurel, MD 20723 USA. [Bower, Kraig S.] Walter Reed Army Med Ctr, Ophthalmol Serv, Bethesda, MD 20889 USA. RP Chae, JJ (reprint author), Johns Hopkins Univ, Wilmer Eye Inst, Translat Tissue Engn Ctr, 400 N Wolfe St, Baltimore, MD 21287 USA. RI Guo, Qiongyu/J-3118-2014 FU Congressionally Directed Medical Research Program under the U.S. Army Medical Research and Materiel Command at Fort Detrick, MD [W81XWH-09-2-0173]; Research to Prevent Blindness FX Authors would like to acknowledge Dr. Toshiaki Takezawa for his assistance with CV synthesis technique. This study was funded by the Congressionally Directed Medical Research Program under the U.S. Army Medical Research and Materiel Command at Fort Detrick, MD (Contract No W81XWH-09-2-0173, Program Manager Dr. Dwayne Taliaferro) and the Jules Stein Professorship from Research to Prevent Blindness. NR 31 TC 6 Z9 6 U1 2 U2 16 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUN PY 2014 VL 179 IS 6 BP 686 EP 694 DI 10.7205/MILMED-D-13-00360 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA AN7UM UT WOS:000340806500016 PM 24902138 ER PT J AU Sherry, DM AF Sherry, David M. TI IF A TREE FALLS IN THE WOODS AND THE GOVERNMENT DID NOTHING TO CAUSE IT, DOES IT STILL INVOKE THE ENDANGERED SPECIES ACT? EVALUATING KARUK TRIBE V. U.S. FOREST SERVICE AND ITS IMPACT ON AGENCY ACTION UNDER THE ESA SO MILITARY LAW REVIEW LA English DT Article RP Sherry, DM (reprint author), US Army, Judge Advocate Gen Sch TJAGLCS, Ctr Law & Mil Operat, Charlottesville, VA 22911 USA. NR 7 TC 0 Z9 0 U1 3 U2 5 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SUM PY 2014 VL 220 BP 316 EP 343 PG 28 WC Law SC Government & Law GA AN1EE UT WOS:000340324700008 ER PT J AU Preece, BL Olson, JT Reynolds, JP Fanning, JD Haefner, DP AF Preece, Bradley L. Olson, Jeffrey T. Reynolds, Joseph P. Fanning, Jonathan D. Haefner, David P. TI Human vision noise model validation for the US Army sensor performance metric SO OPTICAL ENGINEERING LA English DT Article DE human vision; noise; contrast threshold function; targeting task performance metric; image evaluation; night vision integrated performance model AB Image noise originating from a sensor system is often the limiting factor in target acquisition performance, especially when limited by atmospheric transmission or low-light conditions. To accurately predict target acquisition range performance for a wide variety of imaging systems, image degradation introduced by the sensor must be properly combined with the limitations of the human visual system (HVS). This crucial step of incorporating the HVS has been improved and updated within NVESD's latest imaging system performance model. The new noise model discussed here shows how an imaging system's noise and blur are combined with the contrast threshold function (CTF) to form the system CTF. Model calibration constants were found by presenting low-contrast sine gratings with additive noise in a two alternative forced choice experiment. One of the principal improvements comes from adding an eye photon noise term allowing the noise CTF to be accurate over a wide range of luminance. The latest HVS noise model is then applied to the targeting task performance metric responsible for predicting system performance from the system CTF. To validate this model, human target acquisition performance was measured from a series of infrared and visible-band noise-limited imaging systems. (C) 2014 Society of Photo-Optical Instrumentation Engineers (SPIE) C1 [Preece, Bradley L.; Olson, Jeffrey T.; Reynolds, Joseph P.; Fanning, Jonathan D.; Haefner, David P.] US Army, RDECOM CERDEC Night Vis Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Preece, BL (reprint author), US Army, RDECOM CERDEC Night Vis Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. EM bradley.l.preece.civ@mail.mil NR 21 TC 5 Z9 5 U1 0 U2 4 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 EI 1560-2303 J9 OPT ENG JI Opt. Eng. PD JUN PY 2014 VL 53 IS 6 AR 061712 DI 10.1117/1.OE.53.6.061712 PG 14 WC Optics SC Optics GA AN5ZR UT WOS:000340672800015 ER PT J AU Tong, XL Luke, EA Smith, R AF Tong, Xiaoling Luke, Edward A. Smith, Robert TI Numerical validation of a near-field fugitive dust model for vehicles moving on unpaved surfaces SO PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART D-JOURNAL OF AUTOMOBILE ENGINEERING LA English DT Article DE Fugitive dust emissions; computational fluid dynamics; multiphase flow; PM10; tire; tyre ID DISPERSION; WIND; EMISSIONS; LAYER AB This paper presents a numerical model for evaluating fugitive dust emissions and transport in a near field induced by a moving vehicle. The dust emission model describes the quantity and location of emitted dust. The transport of the dust is recorded by the Lagrangian particle-tracking method, and the turbulence dispersion of particles is modeled stochastically. The presented model is validated numerically for the prediction of dust concentration in a region near the vehicles through a careful comparison with the available experimental data. The simulation results compare reasonably well with the experimental data. This model provides, for the first time, a validated dust emission and transport model suitable for the near field of moving vehicles. C1 [Tong, Xiaoling] Mississippi State Univ, Ctr Adv Vehicular Syst, Starkville, MS 39759 USA. [Luke, Edward A.] Mississippi State Univ, Dept Comp Sci, Starkville, MS 39759 USA. [Smith, Robert] US Army Res Dev & Engn Command, Tank Automot Res Dev & Engn Ctr, Warren, MI USA. RP Tong, XL (reprint author), Mississippi State Univ, Simctr, Ctr Adv Vehicular Syst, 2 Res Blvd, Starkville, MS 39759 USA. EM xltong@cavs.msstate.edu FU US Army TACOM Life Cycle Command through Mississippi State University [W56HZV-08-C-0236] FX This work was supported by the US Army TACOM Life Cycle Command (contract number W56HZV-08-C-0236), through a subcontract with Mississippi State University, and was performed for the Simulation Based Reliability and Safety (SimBRS) research program. NR 42 TC 0 Z9 0 U1 0 U2 5 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0954-4070 EI 2041-2991 J9 P I MECH ENG D-J AUT JI Proc. Inst. Mech. Eng. Part D-J. Automob. Eng. PD JUN PY 2014 VL 228 IS 7 BP 747 EP 757 DI 10.1177/0954407013512291 PG 11 WC Engineering, Mechanical; Transportation Science & Technology SC Engineering; Transportation GA AM9XU UT WOS:000340235100004 ER PT J AU Rao, SS Prater, JT Wu, F Nori, S Kumar, D Yue, L Liou, SH Narayan, J AF Rao, S. S. Prater, J. T. Wu, Fan Nori, S. Kumar, D. Yue, L. Liou, S. -H. Narayan, J. TI Positive exchange bias in epitaxial permalloy/MgO integrated with Si (100) SO CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE LA English DT Review DE Positive exchange bias; Permalloy islands; Epitaxial integration; Pulsed laser deposition; Domain matching epitaxy ID BILAYERS; FILMS; NANOPARTICLES; DEPENDENCE; THICKNESS; NIO; MGO AB In magnetic random access memory (MRAM) devices, soft magnetic thin film elements such as permalloy (Py) are used as unit cells of information. The epitaxial integration of these elements with the technologically important substrate Si (1 0 0) and a thorough understanding of their magnetic properties are critical for CMOS-based magnetic devices. We report on the epitaxial growth of Ni82.5Fe17.5 (permalloy, Py) on Si (1 0 0) using a TiN/MgO buffer layer. Initial stages of growth are characterized by the formation of discrete islands that gradually merge into a continuous film as deposition times are extended. Interestingly, we find that the magnetic features of Py films in early stages of island coalescence are distinctly different from the films formed initially (discrete islands) and after extended deposition times (narrow distribution of equiaxed granular films). Isothermal in-plane and out-of-plane magnetic measurements performed on these transitional films show highly anisotropic magnetic behavior with an easy magnetization axis lying in the plane of the film. Importantly, when this sample is zero-field cooled, a positive exchange bias and vertical loop shift are observed, unusual for a soft ferromagnet like Py. Repeated field cycling and hysteresis loops up to the fields of 7T produced reproducible hysteresis loops indicating the existence of strongly pinned spin configurations. Classical interface related exchange bias models cannot explain the observed magnetic features of the transitional Py films. We believe that the anomalous magnetic behavior of such Py films may be explained by considering the highly irregular morphology that develops at intermediate growth times that are possibly also undergoing a transition from Bloch to Neel domain wall structures as a function of Py island size. This study broadens the current understanding of magnetic properties of Py thin layers for technological applications in magneto-electronic devices, integrated with Si (1 0 0). (C) 2014 Elsevier Ltd. All rights reserved. C1 [Rao, S. S.; Prater, J. T.] Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. [Rao, S. S.; Prater, J. T.; Wu, Fan; Nori, S.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Kumar, D.] North Carolina A&T Univ, Ctr Adv Mat & Smart Struct, Greensboro, NC 27411 USA. [Yue, L.; Liou, S. -H.; Narayan, J.] Univ Nebraska, Dept Phys, Lincoln, NE 68588 USA. RP Rao, SS (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. EM ssingam@ncsu.edu RI Nori, Sudhakar/E-8111-2010; OI , fan/0000-0001-5000-0592 FU State of North Carolina; National Science Foundation FX Also, the authors acknowledge the use of the Analytical Instrumentation Facility (AIF) at North Carolina State University, which is supported by the State of North Carolina and the National Science Foundation. NR 37 TC 10 Z9 10 U1 7 U2 44 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-0286 EI 1879-0348 J9 CURR OPIN SOLID ST M JI Curr. Opin. Solid State Mat. Sci. PD JUN PY 2014 VL 18 IS 3 BP 140 EP 146 DI 10.1016/j.cossms.2014.02.001 PG 7 WC Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA AM2SL UT WOS:000339701000002 ER PT J AU Tipping, PW Sosa, A Pokorny, EN Foley, J Schmitz, DC Lane, JS Rodgers, L Mccloud, L Livingston-Way, P Cole, MS Nichols, G AF Tipping, Philip W. Sosa, Alejandro Pokorny, Eileen N. Foley, Jeremiah Schmitz, Don C. Lane, Jon S. Rodgers, Leroy Mccloud, Lori Livingston-Way, Pam Cole, Matthew S. Nichols, Gary TI RELEASE AND ESTABLISHMENT OF MEGAMELUS SCUTELLARIS (HEMIPTERA: DELPHACIDAE) ON WATERHYACINTH IN FLORIDA SO FLORIDA ENTOMOLOGIST LA English DT Editorial Material DE Megamelus scutellaris; Eichhornia crassipes; establishment AB More than 73,000 Megamelus scutellaris (Hemiptera: Delphacidae) were released in Florida over a 2 to 3 yr period at 10 sites in an attempt to establish sustainable populations on waterhyacinth, Eichhornia crassipes Mart. Solms (Commelinales: Pontederiaceae). Insect populations persisted at most sites including those furthest north and consecutive overwintering was confirmed in as many as three times at some sites. Establishment appeared to be promoted at sites with some cover or shading compared to open areas. Insects readily dispersed over short distances which made detection and monitoring difficult. C1 [Tipping, Philip W.; Pokorny, Eileen N.; Foley, Jeremiah] ARS, USDA, Invas Plant Res Lab, Davie, FL 33314 USA. [Sosa, Alejandro] FUEDEI Simon Bolivar 1559, Buenos Aires, DF, Argentina. [Schmitz, Don C.] Florida Fish & Wildlife Conservat Commiss, Tallahassee, FL 32399 USA. [Lane, Jon S.] US Army Corps Engineers, Jacksonville, FL 32207 USA. [Rodgers, Leroy] South Florida Water Management Dist, W Palm Beach, FL 33406 USA. [Mccloud, Lori; Livingston-Way, Pam; Cole, Matthew S.; Nichols, Gary] St Johns River Water Management Dist, Palatka, FL 32178 USA. RP Tipping, PW (reprint author), ARS, USDA, Invas Plant Res Lab, 3225 Coll Ave, Davie, FL 33314 USA. EM philip.tipping@ars.usda.gov NR 5 TC 4 Z9 4 U1 1 U2 9 PU FLORIDA ENTOMOLOGICAL SOC PI LUTZ PA 16125 E LAKE BURRELL DR, LUTZ, FL 33548 USA SN 0015-4040 EI 1938-5102 J9 FLA ENTOMOL JI Fla. Entomol. PD JUN PY 2014 VL 97 IS 2 BP 804 EP 806 PG 3 WC Entomology SC Entomology GA AM2CX UT WOS:000339657600064 ER PT J AU Lebaron, N Zhang, X Herrell, R Yung, E Iskric, A Cho, S Low, N AF Lebaron, N. Zhang, X. Herrell, R. Yung, E. Iskric, A. Cho, S. Low, N. TI Anxious and suicidal behaviors among relatives are associated with suicide attempts and hospitalizations in mood disorder subjects SO INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY LA English DT Meeting Abstract CT 29th CINP World Congress of Neuropsychopharmacology CY JUN 22-26, 2014 CL Vancouver, CANADA SP CINP C1 [Lebaron, N.; Zhang, X.; Yung, E.; Iskric, A.; Cho, S.; Low, N.] McGill Univ, Montreal, PQ, Canada. [Herrell, R.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1461-1457 EI 1469-5111 J9 INT J NEUROPSYCHOPH JI Int. J. Neuropsychopharmacol. PD JUN PY 2014 VL 17 SI 1 MA P-51-001 BP 165 EP 165 PG 1 WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA AM3RB UT WOS:000339769200627 ER PT J AU Keller, CB AF Keller, Christian B. TI German Immigrants, Race, and Citizenship in the Civil War Era SO JOURNAL OF AMERICAN HISTORY LA English DT Book Review C1 [Keller, Christian B.] US Army War Coll, Carlisle, PA 17013 USA. RP Keller, CB (reprint author), US Army War Coll, Carlisle, PA 17013 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ORGANIZATION AMER HISTORIANS PI BLOOMINGTON PA 112 N BRYAN ST, BLOOMINGTON, IN 47408 USA SN 0021-8723 EI 1945-2314 J9 J AM HIST JI J. Am. Hist. PD JUN PY 2014 VL 101 IS 1 BP 271 EP 272 DI 10.1093/jahist/jau249 PG 4 WC History SC History GA AM5JG UT WOS:000339893000068 ER PT J AU Tolisano, AM Bager, JM AF Tolisano, Anthony M. Bager, Jennifer M. TI Sleep Surgery and Medical Malpractice SO LARYNGOSCOPE LA English DT Article DE Sleep surgery; medical malpractice ID NEGLIGENCE CLAIMS; LITIGATION; GLAND AB Objectives/Hypothesis: To describe and analyze the causes and outcomes of lawsuits pertaining to sleep surgery to mitigate future litigation and improve physician education. Study Design: A retrospective review of a publicly available database containing jury verdicts and settlements. Methods: The LexisNexis MEGA Jury Verdicts and Settlements database was reviewed for all lawsuits including settlements and trial verdicts related to sleep surgery. Data including type of surgery performed, plaintiff allegation, nature of injury, outcomes, and indemnities were collected and analyzed. Results: Fifty-one cases met the inclusion criteria. Of these, 30 were decided by a jury, nine were settled out of court, and 10 were resolved by other means. Overall, 57% of known outcomes favored the defendant. The most common surgery performed was tonsillectomy (57%), followed by uvulopalatopharyngoplasty (45%), adenoidectomy (31%), and septoplasty (31%). No difference was found between outcomes when comparing the most common injuries cited, including wrongful death (P = .572), airway compromise (P = .376), and drug reaction (P = .443). If failure to recognize a complication (P = .034) or delay in diagnosis (P = .026) was a component of the legal allegations, the outcome significantly favored the plaintiff. The median settlement ($545,000) and plaintiff award ($1.45 million) were not significantly different (P = .13). Conclusions: The majority of outcomes favored the defendant. Type of injury did not predict outcome. Failure to recognize complications and delay in diagnosis strongly predicted a verdict in favor of the plaintiff. C1 [Tolisano, Anthony M.; Bager, Jennifer M.] Tripler Army Med Ctr, Dept Otolaryngol, Honolulu, HI 96859 USA. RP Tolisano, AM (reprint author), Tripler Army Med Ctr, Dept Otolaryngol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM anthony.m.tolisano.mil@mail.mil NR 17 TC 4 Z9 4 U1 1 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0023-852X EI 1531-4995 J9 LARYNGOSCOPE JI Laryngoscope PD JUN PY 2014 VL 124 IS 6 BP E250 EP E254 DI 10.1002/lary.24559 PG 5 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA AL9SF UT WOS:000339480400008 PM 24347364 ER PT J AU Song, DJ Lanzi, JT Groth, AT Drake, M Orchowski, JR Shaha, SH Lindell, KK AF Song, Daniel J. Lanzi, Joseph T. Groth, Adam T. Drake, Matthew Orchowski, Joseph R. Shaha, Steven H. Lindell, Kenneth K. TI The Effect of Syndesmosis Screw Removal on the Reduction of the Distal Tibiofibular Joint: A Prospective Radiographic Study SO FOOT & ANKLE INTERNATIONAL LA English DT Article DE syndesmosis; syndesmosis malreduction; ankle fracture ID ANKLE FRACTURES; FIXATION; MALREDUCTION AB Background: Injury to the tibiofibular syndesmosis is frequent with rotational ankle injuries. Multiple studies have shown a high rate of syndesmotic malreduction with the placement of syndesmotic screws. There are no studies evaluating the reduction or malreduction of the syndesmosis after syndesmotic screw removal. The purpose of this study was to prospectively evaluate syndesmotic reduction with CT scans and to determine the effect of screw removal on the malreduced syndesmosis. Methods: This was an IRB-approved prospective radiographic study. Patients over 18 years of age treated at 1 institution between August 2008 and December 2011 with intraoperative evidence of syndesmotic disruption were enrolled. Postoperative CT scans were obtained of bilateral ankles within 2 weeks of operative fixation. Syndesmotic screws were removed after 3 months, and a second CT scan was then obtained 30 days after screw removal. Using axial CT images, syndesmotic reduction was evaluated compared to the contralateral uninjured ankle. Twenty-five patients were enrolled in this prospective study. The average age was 25.7 (range, 19 to 35), with 3 females and 22 males. Results: Nine patients (36%) had evidence of tibiofibular syndesmosis malreduction on their initial postoperative axial CT scans. In the postsyndesmosis screw removal CT scan, 8 of 9 or 89% of malreductions showed adequate reduction of the tibiofibular syndesmosis. There was a statistically significant reduction in syndesmotic malreductions (t = 3.333, P<.001) between the initial rate of malreduction after screw placement of 36% (9/25) and the rate of malreduction after all screws were removed of 4% (1/25). Conclusions: Despite a high rate of initial malreduction (36%) after syndesmosis screw placement, 89% of the malreduced syndesmoses spontaneously reduced after screw removal. Syndesmotic screw removal may be advantageous to achieve final anatomic reduction of the distal tibiofibular joint, and we recommend it for the malreduced syndesmosis. Level of Evidence: Level IV, prognostic case series. C1 [Song, Daniel J.] Landstuhl Reg Med Ctr, Orthopaed Surg Serv, Landstuhl, Germany. [Lanzi, Joseph T.; Groth, Adam T.; Drake, Matthew; Orchowski, Joseph R.; Lindell, Kenneth K.] Tripler Army Med Ctr, Honolulu, HI USA. [Shaha, Steven H.] Univ Utah, Ctr Policy & Publ Adm, Salt Lake City, UT USA. [Shaha, Steven H.] Allscripts, Chicago, IL USA. RP Song, DJ (reprint author), Landstuhl Reg Med Ctr, Orthopaed Surg Serv, APO, CMR 402 Box 445,AE 09180, Landstuhl, Germany. EM danieljsong@gmail.com RI Groth, Adam/P-9366-2016 OI Groth, Adam/0000-0003-2475-6200 NR 14 TC 13 Z9 15 U1 0 U2 2 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1071-1007 EI 1944-7876 J9 FOOT ANKLE INT JI Foot Ankle Int. PD JUN PY 2014 VL 35 IS 6 BP 543 EP 548 DI 10.1177/1071100714524552 PG 6 WC Orthopedics SC Orthopedics GA AL7QN UT WOS:000339329800002 PM 24532699 ER PT J AU Nataraj, L Jackson, A Giri, L Atwater, T Hubbard, C Bundy, M AF Nataraj, Latha Jackson, Aaron Giri, Lily Atwater, Terrill Hubbard, Clifford Bundy, Mark TI Synthesis and Characterization of Doped Group-IV Semiconductor Nanocrystals SO NANOSCIENCE AND NANOTECHNOLOGY LETTERS LA English DT Article DE Germanium; Doped Nanocrystals; Optoelectronic Properties ID SILICON AB Doped semiconductor nanocrystals show great promise for several applications in microelectronics and integrated optoelectronics. Nanocrystal based technology has the potential to revolutionize several fields of technology such as thin conducting films, light emitting devices, tunable lasers, transistors, and photovoltaics, and to provide less harmful alternatives to toxic fluorescent dyes for application in bio-imaging, to name a few. While properties of nanocrystals are clearly dependent on their size, considerable research is underway to explore the influence of dopants on the properties of semiconductor nanocrystals. The nanoscale dimensions make elusive the introduction of dopants into these confined structures. Also, there is the possibility of making them degenerate even with the addition of very small quantities of the dopant. Here, we present a facile, low-cost procedure that we have developed for the synthesis of non-degenerate doped semiconductor nanocrystals and study their properties. C1 [Nataraj, Latha; Jackson, Aaron; Giri, Lily; Atwater, Terrill; Hubbard, Clifford; Bundy, Mark] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Nataraj, L (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 18 TC 0 Z9 0 U1 4 U2 16 PU AMER SCIENTIFIC PUBLISHERS PI VALENCIA PA 26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USA SN 1941-4900 EI 1941-4919 J9 NANOSCI NANOTECH LET JI Nanosci. Nanotechnol. Lett. PD JUN PY 2014 VL 6 IS 6 BP 502 EP 504 DI 10.1166/nnl.2014.1797 PG 3 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Science & Technology - Other Topics; Materials Science; Physics GA AL8ZJ UT WOS:000339428200009 ER PT J AU Simpson, D Post, PG Young, G Jensen, PR AF Simpson, Duncan Post, Phillip G. Young, Greg Jensen, Peter R. TI "It's Not About Taking the Easy Road": The Experiences of Ultramarathon Runners SO SPORT PSYCHOLOGIST LA English DT Article DE endurance; running; phenomenology; sport psychology ID PHENOMENOLOGY; PARTICIPANTS AB Ultramarathon (UM) running is a rapidly growing sport throughout the world, yet to date it has received little attention in sport psychology literature. To obtain further insight into this sport, the current study examined the training and competition experiences of UM runners. Phenomenological interviews were conducted with 26 participants ranging in age from 32 to 67 years (M = 44.1 yrs, SD = 8.1). Qualitative analysis of the interview data identified meaning units, which were grouped into major themes. A final thematic structure revealed five major themes that characterized the participant's experience of UM running: preparation and strategy, management, discovery, personal achievement, and community. Taken together, the present results extend previous research on UM running and provide a number of suggestions for sport psychology consultants working with UM runners. C1 [Simpson, Duncan] Barry Univ, Dept Sport & Exercise Sci, Miami, FL 33161 USA. [Post, Phillip G.] New Mexico State Univ, Dept Human Performance Dance & Recreat, Las Cruces, NM 88003 USA. [Young, Greg] Liverpool John Moores Univ, Dept Phys Educ Sport Dev & Coaching, Liverpool L3 5UX, Merseyside, England. [Jensen, Peter R.] US Mil Acad, Ctr Enhanced Performance, West Point, NY 10996 USA. RP Simpson, D (reprint author), Barry Univ, Dept Sport & Exercise Sci, Miami, FL 33161 USA. EM Dsimpson@mail.barry.edu NR 33 TC 4 Z9 4 U1 2 U2 19 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 0888-4781 EI 1543-2793 J9 SPORT PSYCHOL JI Sport Psychol. PD JUN PY 2014 VL 28 IS 2 BP 176 EP 185 DI 10.1123/tsp.2013-0064 PG 10 WC Hospitality, Leisure, Sport & Tourism; Psychology, Applied; Psychology; Sport Sciences SC Social Sciences - Other Topics; Psychology; Sport Sciences GA AL6WP UT WOS:000339274500006 ER PT J AU Heine, HS Louie, A Adamovicz, JJ Amemiya, K Fast, RL Miller, L Opal, SM Palardy, J Parejo, NA Sorgel, F Kinzig-Schippers, M Drusano, GL AF Heine, Henry S. Louie, Arnold Adamovicz, Jeffrey J. Amemiya, Kei Fast, Randy L. Miller, Lynda Opal, Steven M. Palardy, John Parejo, Nicolas A. Soergel, Fritz Kinzig-Schippers, Martina Drusano, George L. TI Evaluation of Imipenem for Prophylaxis and Therapy of Yersinia pestis Delivered by Aerosol in a Mouse Model of Pneumonic Plague SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID LIPOPOLYSACCHARIDE; INTERLEUKIN-10; PHARMACOKINETICS; PHARMACODYNAMICS; TEMPERATURE; CILASTATIN; INTERFERON; MONOCYTES; INFECTION; CYTOKINES AB It has been previously shown that mice subjected to an aerosol exposure to Yersinia pestis and treated with beta-lactam antibiotics after a delay of 42 h died at an accelerated rate compared to controls. It was hypothesized that endotoxin release in antibiotic-treated mice accounted for the accelerated death rate in the mice exposed to aerosol Y. pestis. Imipenem, a beta-lactam antibiotic, binds to penicillin binding protein 2 with the highest affinity and produces rounded cells. The binding of imipenem causes cells to lyse quickly and thereby to release less free endotoxin. Two imipenem regimens producing fractions of time that the concentration of free, unbound drug was above the MIC (fT > MIC) of approximately 25% (6/24 h) and 40% (9.5/24 h) were evaluated. In the postexposure prophylaxis study, the 40% and 25% regimens produced 90% and 40% survivorship, respectively. In the 42-h treatment study, both regimens demonstrated a 40 to 50% survivorship at therapy cessation and some deaths thereafter, resulting in a 30% survivorship. As this was an improvement over the results with other beta-lactams, a comparison of both endotoxin and cytokine levels in mice treated with imipenem and ceftazidime (a beta-lactam previously demonstrated to accelerate death in mice during treatment) was performed and supported the original hypotheses; however, the levels observed in animals treated with ciprofloxacin (included as an unrelated antibiotic that is also bactericidal but should cause little lysis due to a different mode of action) were elevated and significantly (7-fold) higher than those with ceftazidime. C1 [Heine, Henry S.; Louie, Arnold; Drusano, George L.] Univ Florida, Res & Acad Ctr, Inst Innovat Therapeut, Orlando, FL 32816 USA. [Adamovicz, Jeffrey J.] Univ Wyoming, Laramie, WY 82071 USA. [Amemiya, Kei; Fast, Randy L.; Miller, Lynda] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. [Opal, Steven M.; Palardy, John; Parejo, Nicolas A.] Brown Univ, Alpert Med Sch, Providence, RI 02912 USA. [Soergel, Fritz; Kinzig-Schippers, Martina] Inst Biomed & Pharmaceut Res, Nurnberg, Germany. [Soergel, Fritz] Univ Duisburg Essen, Fac Med, Inst Pharmacol, Duisburg, Germany. RP Heine, HS (reprint author), Univ Florida, Res & Acad Ctr, Inst Innovat Therapeut, Orlando, FL 32816 USA. EM hsheine@ufl.edu FU Defense Threat Reduction Agency [CB2544]; JSTO/DTRA [1.1A0018_07_RD_B]; [1 PO1 AI060908-01A1] FX The research described here was sponsored by 1 PO1 AI060908-01A1, a Program Project Grant to G.L.D. and the Defense Threat Reduction Agency, and project no. CB2544 to H.S.H. In addition, funding from JSTO/DTRA, project no. 1.1A0018_07_RD_B, to K.A. is acknowledged. NR 31 TC 2 Z9 2 U1 0 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD JUN PY 2014 VL 58 IS 6 BP 3276 EP 3284 DI 10.1128/AAC.02420-14 PG 9 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA AK9VP UT WOS:000338776900036 PM 24687492 ER PT J AU Salje, H Rodriguez-Barraquer, I Rainwater-Lovett, K Nisalak, A Thaisomboonsuk, B Thomas, SJ Fernandez, S Jarman, RG Yoon, IK Cummings, DAT AF Salje, Henrik Rodriguez-Barraquer, Isabel Rainwater-Lovett, Kaitlin Nisalak, Ananda Thaisomboonsuk, Butsaya Thomas, Stephen J. Fernandez, Stefan Jarman, Richard G. Yoon, In-Kyu Cummings, Derek A. T. TI Variability in Dengue Titer Estimates from Plaque Reduction Neutralization Tests Poses a Challenge to Epidemiological Studies and Vaccine Development SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID AOTUS MONKEYS; DV INFECTION; DNA VACCINE; VIRUS; ANTIBODIES; CHILDREN; THAILAND; ASSAY; IMMUNOGENICITY; PROTECTION AB Background: Accurate determination of neutralization antibody titers supports epidemiological studies of dengue virus transmission and vaccine trials. Neutralization titers measured using the plaque reduction neutralization test (PRNT) are believed to provide a key measure of immunity to dengue viruses, however, the assay's variability is poorly understood, making it difficult to interpret the significance of any assay reading. In addition there is limited standardization of the neutralization evaluation point or statistical model used to estimate titers across laboratories, with little understanding of the optimum approach. Methodology/Principal Findings: We used repeated assays on the same two pools of serum using five different viruses (2,319 assays) to characterize the variability in the technique under identical experimental conditions. We also assessed the performance of multiple statistical models to interpolate continuous values of neutralization titer from discrete measurements from serial dilutions. We found that the variance in plaque reductions for individual dilutions was 0.016, equivalent to a 95% confidence interval of 0.45-0.95 for an observed plaque reduction of 0.7. We identified PRNT75 as the optimum evaluation point with a variance of 0.025 (log(10) scale), indicating a titer reading of 1: 500 had 95% confidence intervals of 1:240-1:1000 (2.70 +/- 0.31 on a log(10) scale). The choice of statistical model was not important for the calculation of relative titers, however, cloglog regression out-performed alternatives where absolute titers are of interest. Finally, we estimated that only 0.7% of assays would falsely detect a four-fold difference in titers between acute and convalescent sera where no true difference exists. Conclusions: Estimating and reporting assay uncertainty will aid the interpretation of individual titers. Laboratories should perform a small number of repeat assays to generate their own variability estimates. These could be used to calculate confidence intervals for all reported titers and allow benchmarking of assay performance. C1 [Salje, Henrik; Rodriguez-Barraquer, Isabel; Rainwater-Lovett, Kaitlin; Cummings, Derek A. T.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA. [Nisalak, Ananda; Thaisomboonsuk, Butsaya; Fernandez, Stefan; Yoon, In-Kyu] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Thomas, Stephen J.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA. [Jarman, Richard G.] Walter Reed Army Inst Res, Div Communicable Dis & Immunol, Silver Spring, MD USA. RP Salje, H (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA. EM hsalje1@jhu.edu OI Salje, Henrik/0000-0003-3626-4254 FU Bill and Melinda Gates Foundation Vaccine Modeling Initiative; National Institute of General Medical Sciences [U54 GM088491-0109] FX The study was supported by the Bill and Melinda Gates Foundation Vaccine Modeling Initiative and the National Institute of General Medical Sciences (U54 GM088491-0109). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 31 TC 8 Z9 8 U1 0 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD JUN PY 2014 VL 8 IS 6 AR e2952 DI 10.1371/journal.pntd.0002952 PG 10 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AL0VW UT WOS:000338846100057 PM 24967885 ER PT J AU Sauers, SE Scofield, DE AF Sauers, Sarah E. Scofield, Dennis E. TI Strength and Conditioning Strategies for Females in the Military SO STRENGTH AND CONDITIONING JOURNAL LA English DT Article ID UNDULATING PERIODIZED PROGRAMS; PLYOMETRIC TRAINING-PROGRAM; STRESS-FRACTURES; RISK-FACTORS; COMBINED RESISTANCE; PHYSICAL-FITNESS; BODY-COMPOSITION; EQUATED VOLUME; INJURIES; WOMEN AB MILITARY PERSONNEL ARE REQUIRED TO POSSESS A MYRIAD OF PHYSICAL CAPABILITIES THAT DRAW ON ALL FACETS OF PHYSICAL AND MENTAL FITNESS. THE PHYSIOLOGICAL DEMANDS OF MILITARY OCCUPATIONAL TASKS CAN POTENTIALLY CHALLENGE MULTIPLE COMPONENTS OF THE ENERGY SYSTEM CONTINUUM. STRENGTH AND CONDITIONING PROGRAMS FOR FEMALE SOLDIERS SHOULD BE PERIODIZED, TASK-SPECIFIC TRAINING. THIS ARTICLE WILL DISCUSS PEER-REVIEWED RESEARCH REGARDING PHYSICAL RESPONSES TO VARIOUS EXERCISE STIMULI AND MILITARY MOVEMENTS, THE IMPORTANCE OF A PERIODIZED PHYSICAL TRAINING PROGRAM FOR FEMALE SOLDIERS, AND SUGGEST TRAINING STRATEGIES TO IMPROVE PHYSICAL AND MILITARY PERFORMANCE. C1 [Sauers, Sarah E.; Scofield, Dennis E.] US Army Res Inst Environm Med, Natick, MA 01760 USA. RP Sauers, SE (reprint author), US Army Res Inst Environm Med, Natick, MA 01760 USA. RI SCOFIELD, DENNIS/F-3636-2015 NR 41 TC 1 Z9 1 U1 3 U2 12 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1524-1602 EI 1533-4295 J9 STRENGTH COND J JI Strength Cond. J. PD JUN PY 2014 VL 36 IS 3 BP 1 EP 7 PG 7 WC Sport Sciences SC Sport Sciences GA AL4KL UT WOS:000339101700001 ER PT J AU Sanamyan, T Cooper, C Gilde, G Sutorik, AC Dubinskii, M AF Sanamyan, T. Cooper, C. Gilde, G. Sutorik, A. C. Dubinskii, M. TI Fabrication and spectroscopic properties of transparent Nd3+:MgO and Er3+:MgO ceramics SO LASER PHYSICS LETTERS LA English DT Article DE MgO; Er-doped; Nd-doped; spectroscopy; laser ID THERMAL-CONDUCTIVITY; CRYSTALS; LASERS; MGO AB We present the results of the development and comprehensive characterization of fully densified Er3+:MgO and Nd3+:MgO transparent ceramics fabricated from specially formulated nanopowders. Also presented are the spectroscopic characterization results (absorption, fluorescence and emission lifetimes) of Er3+ and Nd3+ dopant ions in MgO in the temperature range 10 to 300 K. To the best of our knowledge, this is the first reported successful demonstration of bulk MgO host material doped with rare earth (RE) ions. Spectroscopic results are indicative of a single-site RE ion incorporation with a nearly perfect single crystalline environment within the MgO ceramic grains. The results are presented with major emphasis on potential laser application and the outlook for substantially improved laser power scaling at room temperature based on the unique thermal properties of the host material. C1 [Sanamyan, T.; Dubinskii, M.] RDRL WMM E US Army Res Lab, Adelphi, MD 20783 USA. [Cooper, C.; Gilde, G.; Sutorik, A. C.] RDRL SEE M US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Sanamyan, T (reprint author), RDRL WMM E US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM tigran.sanamyan.civ@mail.mil FU High Energy Laser Joint Technology Office FX The authors gratefully acknowledge financial support of this work by the High Energy Laser Joint Technology Office. NR 18 TC 0 Z9 0 U1 1 U2 20 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 1612-2011 EI 1612-202X J9 LASER PHYS LETT JI Laser Phys. Lett. PD JUN 1 PY 2014 VL 11 IS 6 AR 065801 DI 10.1088/1612-2011/11/6/065801 PG 7 WC Optics; Physics, Applied SC Optics; Physics GA AK7YC UT WOS:000338642700014 ER PT J AU Fang, WJ Hsu, AL Song, Y Birdwell, AG Amani, M Dubey, M Dresselhaus, MS Palacios, T Kong, J AF Fang, Wenjing Hsu, Allen L. Song, Yi Birdwell, Anthony G. Amani, Matin Dubey, Madan Dresselhaus, Mildred S. Palacios, Tomas Kong, Jing TI Asymmetric Growth of Bilayer Graphene on Copper Enclosures Using Low-Pressure Chemical Vapor Deposition SO ACS NANO LA English DT Article DE bilayer graphene; Cu enclosure; growth mechanism; carbon diffusion ID LARGE-AREA; HIGH-QUALITY; FILMS; CU; GRAPHITE; NUCLEATION; PYROLYSIS; SURFACES; KINETICS; HYDROGEN AB In this work, we investigated the growth mechanisms of bilayer graphene on the outside surface of Cu enclosures at low pressures. We observed that the asymmetric growth environment of a Cu enclosure can yield a much higher (up to 100%) bilayer coverage on the outside surface as compared to the bilayer growth on a flat Cu foil, where both sides are exposed to the same growth environment. By simultaneously examining the graphene films grown on both the outside and inside surfaces of the Cu enclosure, we find that carbon can diffuse from the inside surface to the outside via exposed copper regions on the inside surface. The kinetics of this process are examined by coupling the asymmetric growth between the two surfaces through a carbon diffusion model. Finally, using these results, we show that the coverage of bilayer graphene can be tuned simply by changing the thickness of the Cu foil, further confirming our model of carbon delivery through the Cu foil. C1 [Fang, Wenjing; Hsu, Allen L.; Song, Yi; Dresselhaus, Mildred S.; Palacios, Tomas; Kong, Jing] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA. [Dresselhaus, Mildred S.] MIT, Dept Phys, Cambridge, MA 02139 USA. [Birdwell, Anthony G.; Amani, Matin; Dubey, Madan] US Army Res Lab, Adelphi, MD 20783 USA. RP Kong, J (reprint author), MIT, Dept Elect Engn & Comp Sci, 77 Mass Ave, Cambridge, MA 02139 USA. EM jingkong@mit.edu FU National Science Foundation [NSF DMR 0845358]; Graphene Approaches to Terahertz Electronics (GATE) Multidisciplinary University Research Initiative (MURI) of Massachusetts Institute of Technology (MIT)-Harvard University-Boston University through the Office of Naval Research (ONR); Army Research Labs (ARL); [ONR-MURI-N00014-09-1-1063] FX This work was partially supported by National Science Foundation under award number NSF DMR 0845358 and the Graphene Approaches to Terahertz Electronics (GATE) Multidisciplinary University Research Initiative (MURI) of Massachusetts Institute of Technology (MIT)-Harvard University-Boston University through the Office of Naval Research (ONR), and the Army Research Labs (ARL). M.S.D. acknowledges ONR-MURI-N00014-09-1-1063. NR 36 TC 26 Z9 26 U1 12 U2 83 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1936-0851 EI 1936-086X J9 ACS NANO JI ACS Nano PD JUN PY 2014 VL 8 IS 6 BP 6491 EP 6499 DI 10.1021/nn5015177 PG 9 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA AK0FV UT WOS:000338089200119 PM 24878354 ER PT J AU Yeap, EE Morrison, JJ Apodaca, AN Egan, G Jansen, JO AF Yeap, E. E. Morrison, J. J. Apodaca, A. N. Egan, G. Jansen, J. O. TI Trauma care in Scotland: effect of rurality on ambulance travel times and level of destination healthcare facility SO EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY LA English DT Article DE Traumatology; Rurality; Trauma systems; Scotland ID MORTALITY; URBAN AB The aim of this study was to determine the effect of rurality on the level of destination healthcare facility and ambulance response times for trauma patients in Scotland. We used a retrospective analysis of pre-hospital data routinely collected by the Scottish Ambulance Service from 2009-2010. Incident locations were categorised by rurality, using the Scottish urban/rural classification. The level of destination healthcare facility was coded as either a teaching hospital, large general hospital, general hospital, or other type of facility. A total of 64,377 incidents met the inclusion criteria. The majority of incidents occurred in urban areas, which mostly resulted in admission to teaching hospitals. Incidents from other areas resulted in admission to a lower-level facility. The majority of incidents originating in very remote small towns and very remote rural areas were treated in a general hospital. Median call-out times and travel times increased with the degree of rurality, although with some exceptions. Trauma is relatively rare in rural areas, but patients injured in remote locations are doubly disadvantaged by prolonged pre-hospital times and admission to a hospital that may not be adequately equipped to deal with their injuries. These problems may be overcome by the regionalisation of trauma care, and enhanced retrieval capability. C1 [Yeap, E. E.] Aberdeen Royal Infirm, Aberdeen, Scotland. [Morrison, J. J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. [Morrison, J. J.] Glasgow Royal Infirm, Acad Surg Unit, Glasgow G4 0SF, Lanark, Scotland. [Apodaca, A. N.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Egan, G.] Scottish Ambulance Serv, Edinburgh, Midlothian, Scotland. [Jansen, J. O.] Aberdeen Royal Infirm, Ward 34, Aberdeen, Scotland. RP Yeap, EE (reprint author), Aberdeen Royal Infirm, Foresterhill, Aberdeen, Scotland. EM eeemin@gmail.com; jan.jansen@nhs.net NR 22 TC 0 Z9 0 U1 0 U2 3 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1863-9933 EI 1863-9941 J9 EUR J TRAUMA EMERG S JI Eur. J. Trauma Emerg. Surg. PD JUN PY 2014 VL 40 IS 3 BP 295 EP 302 DI 10.1007/s00068-014-0383-x PG 8 WC Emergency Medicine SC Emergency Medicine GA AK2CG UT WOS:000338225900010 PM 26816063 ER PT J AU Biss, MM McNesby, KL AF Biss, Matthew M. McNesby, Kevin L. TI Optically measured explosive impulse SO EXPERIMENTS IN FLUIDS LA English DT Article ID CHARGES; ABEL AB An experimental technique is investigated to optically measure the explosive impulse produced by laboratory-scale spherical charges detonated in air. Explosive impulse has historically been calculated from temporal pressure measurements obtained via piezoelectric transducers. The presented technique instead combines schlieren flow visualization and high-speed digital imaging to optically measure explosive impulse. Prior to an explosive event, schlieren system calibration is performed using known light-ray refractions and resulting digital image intensities. Explosive charges are detonated in the test section of a schlieren system and imaged by a high-speed digital camera in pseudo-streak mode. Spatiotemporal schlieren intensity maps are converted using an Abel deconvolution, Rankine-Hugoniot jump equations, ideal gas law, triangular temperature decay profile, and Schardin's standard photometric technique to yield spatiotemporal pressure maps. Temporal integration of individual pixel pressure profiles over the positive pressure duration of the shock wave yields the explosive impulse generated for a given radial standoff. Calculated explosive impulses are shown to exhibit good agreement between optically derived values and pencil gage pressure transducers. C1 [Biss, Matthew M.; McNesby, Kevin L.] US Army Res Lab, Lethal Div, Energet Technol Branch, Aberdeen Proving Ground, MD 21005 USA. RP Biss, MM (reprint author), US Army Res Lab, Lethal Div, Energet Technol Branch, Aberdeen Proving Ground, MD 21005 USA. EM matthew.m.biss.civ@mail.mil FU U.S. Army Research Laboratory's Lethality Division Innovation Program; National Research Council Postdoctoral Fellowship Program FX We would like to acknowledge the U.S. Army Research Laboratory's Lethality Division Innovation Program and the National Research Council Postdoctoral Fellowship Program for funding of this research. We would like to acknowledge Mr. Roy Maulbetsch, Mr. Terry Piatt, and Mrs. Lori Pridgeon of the Ingredient, Formulation, & Processing Team for pressing of the energetic samples and Mr. Richard Benjamin, Mr. William Sickels, Mr. Ray Sparks, Mr. Gene Summers, and Mr. Ronnie Thompson of the Detonation Science Team for their assistance in conducting these experiments, and Ms. Susan Corley at DSC Laboratories for providing the linearly graded filters. Lastly, we would like to acknowledge Dr. Michael Hargather at New Mexico Tech for his thoughtful discussions and insight. NR 20 TC 1 Z9 1 U1 3 U2 18 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0723-4864 EI 1432-1114 J9 EXP FLUIDS JI Exp. Fluids PD JUN PY 2014 VL 55 IS 6 AR 1749 DI 10.1007/s00348-014-1749-x PG 8 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA AK3KL UT WOS:000338322400013 ER PT J AU Britzke, ER Gumbert, MW Hohmann, MG AF Britzke, Eric R. Gumbert, Mark W. Hohmann, Matthew G. TI Behavioral Response of Bats to Passive Integrated Transponder Tag Reader Arrays Placed at Cave Entrances SO JOURNAL OF FISH AND WILDLIFE MANAGEMENT LA English DT Article DE bats; Indiana bat; behavior; passive integrated transponder (PIT) tags ID ROOSTS AB An increasingly popular mark-recapture method to study the ecology of bats is the use of passive integrated transponder (PIT) tags. Deployment of PIT reader arrays at entrances to caves and mines can yield insight into bat behavior during swarming, winter activity, and emergence. This application has the potential to address questions about bat activity at cave and mine entrances in response to white-nose syndrome or bat seasonal movements; however, no studies have examined the response of bats to these arrays. We describe bat response to placement of PIT tag reader arrays using camcorders and supplemental infrared illuminators at three cave entrances near Bloomington, Indiana, during spring 2006. A random subset of 5-min periods was viewed and bat behavior was classified. Circling represented >70% of all behavior noted for two caves but only represented approximately 30% of behavior at the third cave. Proportions of observed activity that resulted in contacts or landings were consistently low across the three caves ((x) over bar = 1.34%; range 0.5-3.0%), with most contacts causing bats to simply change course and fly away. Based on our observations, positioning reader PIT tag reader arrays at cave entrances to passively recapture PIT tags does not limit bat movements. However, video monitoring during initial sampling efforts of future projects should be conducted to verify appropriate placement and configuration of PIT tag reader arrays. This research provides data illustrating the lack of significant impact in using PIT tag reader arrays at cave entrances, thereby opening up the potential use of this technology to address issues of bats ecology that cannot be obtained with other marking techniques. C1 [Britzke, Eric R.] US Army, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Gumbert, Mark W.] Copperhead Environm Consulting Inc, Paint Lick, KY 40461 USA. [Hohmann, Matthew G.] US Army, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. RP Britzke, ER (reprint author), US Army, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Eric.R.Britzke@usace.army.mil FU U.S. Army Corps of Engineers, Construction Engineering Research Laboratory FX The U.S. Army Corps of Engineers, Construction Engineering Research Laboratory provided financial and technical support for this project. C. Hansen designed the supplemental power system for the digital readers and fitted the weatherproof cases with external recharging connectors. P. Frank assisted in the construction of the PIT tag reader arrays. S. Johnson provided invaluable assistance with cave selection, contacting property owners, and PIT tag reader array placement. L. Pruitt and A. King provided guidance on project implementation. D. Everton, K. Dunlap, M. Wright, and M. Lawrence provided cave access. D. Foster, J. Hawkins, C. Leftwich, K. McDonald, P. Roby, and P. Sewell were instrumental in transporting the heavy equipment allowing for data collection for this project. P. Roby and N. Beane, three anonymous reviewers, and the Subject Editor provided constructive comments on an earlier version of this manuscript. NR 15 TC 1 Z9 1 U1 2 U2 36 PU U S FISH & WILDLIFE SERVICE PI SHEPHERDSTOWN PA NATL CONSERVATION TRAINING CENTER, CONSERVATION LIBRARY, 698 CONSERVATION WAY, SHEPHERDSTOWN, WV 25443 USA SN 1944-687X J9 J FISH WILDL MANAG JI J. Fish Wildl. Manag. PD JUN PY 2014 VL 5 IS 1 BP 146 EP 150 DI 10.3996/082012-JFWM-065 PG 5 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA AK5AT UT WOS:000338436900015 ER PT J AU Chung, DH Jonsson, CB Tower, NA Chu, YK Sahin, E Golden, JE Noah, JW Schroeder, CE Sotsky, JB Sosa, MI Cramer, DE McKellip, SN Rasmussen, L White, EL Schmaljohn, CS Julander, JG Smith, JM Filone, CM Connor, JH Sakurai, Y Davey, RA AF Chung, Dong-Hoon Jonsson, Colleen B. Tower, Nichole A. Chu, Yong-Kyu Sahin, Ergin Golden, Jennifer E. Noah, James W. Schroeder, Chad E. Sotsky, Julie B. Sosa, Melinda I. Cramer, Daniel E. McKellip, Sara N. Rasmussen, Lynn White, E. Lucile Schmaljohn, Connie S. Julander, Justin G. Smith, Jeffrey M. Filone, Claire Marie Connor, John H. Sakurai, Yasuteru Davey, Robert A. TI Discovery of a Novel Compound with Anti-Venezuelan Equine Encephalitis Virus Activity That Targets the Nonstructural Protein 2 SO PLOS PATHOGENS LA English DT Article ID SEMLIKI-FOREST-VIRUS; RESPIRATORY SYNCYTIAL VIRUS; ENCEPHALOMYELITIS VIRUS; NSP2 PROTEASE; VACCINES; CELLS; DERIVATIVES; POLYMERASE; MUTATIONS; INFECTION AB Alphaviruses present serious health threats as emerging and re-emerging viruses. Venezuelan equine encephalitis virus (VEEV), a New World alphavirus, can cause encephalitis in humans and horses, but there are no therapeutics for treatment. To date, compounds reported as anti-VEEV or anti-alphavirus inhibitors have shown moderate activity. To discover new classes of anti-VEEV inhibitors with novel viral targets, we used a high-throughput screen based on the measurement of cell protection from live VEEV TC-83-induced cytopathic effect to screen a 340,000 compound library. Of those, we identified five novel anti-VEEV compounds and chose a quinazolinone compound, CID15997213 (IC50 = 0.84 mu M), for further characterization. The antiviral effect of CID15997213 was alphavirus-specific, inhibiting VEEV and Western equine encephalitis virus, but not Eastern equine encephalitis virus. In vitro assays confirmed inhibition of viral RNA, protein, and progeny synthesis. No antiviral activity was detected against a select group of RNA viruses. We found mutations conferring the resistance to the compound in the N-terminal domain of nsP2 and confirmed the target residues using a reverse genetic approach. Time of addition studies showed that the compound inhibits the middle stage of replication when viral genome replication is most active. In mice, the compound showed complete protection from lethal VEEV disease at 50 mg/kg/day. Collectively, these results reveal a potent anti-VEEV compound that uniquely targets the viral nsP2 N-terminal domain. While the function of nsP2 has yet to be characterized, our studies suggest that the protein might play a critical role in viral replication, and further, may represent an innovative opportunity to develop therapeutic interventions for alphavirus infection. C1 [Chung, Dong-Hoon; Jonsson, Colleen B.; Sahin, Ergin] Univ Louisville, Dept Microbiol, Louisville, KY 40292 USA. [Chung, Dong-Hoon; Jonsson, Colleen B.; Sahin, Ergin] Univ Louisville, Dept Immunol, Louisville, KY 40292 USA. [Chung, Dong-Hoon; Jonsson, Colleen B.; Chu, Yong-Kyu; Sahin, Ergin; Sotsky, Julie B.; Cramer, Daniel E.] Univ Louisville, Ctr Predict Med Biodef & Emerging Infect Dis, Louisville, KY 40292 USA. [Jonsson, Colleen B.] Univ Louisville, Dept Pharmacol & Toxicol, Louisville, KY USA. [Tower, Nichole A.; Noah, James W.; Sosa, Melinda I.; McKellip, Sara N.; Rasmussen, Lynn; White, E. Lucile] So Res Inst, Drug Discovery Dept, Birmingham, AL 35255 USA. [Golden, Jennifer E.; Schroeder, Chad E.] Univ Kansas, Specialized Chem Ctr, Lawrence, KS 66045 USA. [Schmaljohn, Connie S.; Smith, Jeffrey M.] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. [Julander, Justin G.] Utah State Univ, Inst Antiviral Res, Logan, UT 84322 USA. [Filone, Claire Marie; Connor, John H.] Boston Univ, Boston, MA 02215 USA. [Sakurai, Yasuteru; Davey, Robert A.] Texas Biomed Res Inst, San Antonio, TX USA. RP Chung, DH (reprint author), Univ Louisville, Dept Microbiol, Louisville, KY 40292 USA. EM dhchun01@louisville.edu OI Connor, John/0000-0002-8867-7256; Golden, Jennifer/0000-0002-6813-3710 FU NIH [R03MH087448-01A1]; University of Louisville Internal Research Initiate; USAMRAA [W81XWH-10-2-0064, W81XWH-08-2-0024] FX This research was supported by the following funding sources: NIH R03MH087448-01A1, University of Louisville Internal Research Initiate grant to DHC, USAMRAA W81XWH-10-2-0064 and W81XWH-08-2-0024 to CBJ. Screening was provided by the Southern Research Specialized Screening Center (U54HG005034-0) and chemistry through the University of Kansas Specialized Chemistry Center (U54HG005031). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 36 TC 9 Z9 9 U1 0 U2 5 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-7366 EI 1553-7374 J9 PLOS PATHOG JI PLoS Pathog. PD JUN PY 2014 VL 10 IS 6 AR e1004213 DI 10.1371/journal.ppat.1004213 PG 10 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA AK1SV UT WOS:000338197400046 PM 24967809 ER PT J AU Walsh, ME Walsh, MR Collins, CM Racine, CH AF Walsh, Marianne E. Walsh, Michael R. Collins, Charles M. Racine, Charles H. TI White Phosphorus Contamination of an Active Army Training Range SO WATER AIR AND SOIL POLLUTION LA English DT Article DE White phosphorus; Ordnance; Remediation; Military training; Waterfowl mortality; Sampling ID SALT-MARSH; REMEDIATION; SEDIMENTS; DUCKS; P-4 AB Detonations of military ordnance will leave various amounts of chemical residue on training ranges. Significant adverse ecological effects from these residues have not been documented except for ordnance containing white phosphorus. At a military training range in Alaska, USA, the deaths of thousands of waterfowl due to poisoning from white phosphorus ordnance prompted a two-decade-long investigation of the extent of the contamination, remediation technologies, and methods to assess and monitor the effectiveness of the remediation. This paper gives an overview of these investigations and provides the outcome of the remediation efforts. C1 [Walsh, Marianne E.; Walsh, Michael R.; Collins, Charles M.; Racine, Charles H.] US Army Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Walsh, ME (reprint author), US Army Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM marianne.e.walsh@usace.army.mil NR 25 TC 1 Z9 1 U1 0 U2 4 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0049-6979 EI 1573-2932 J9 WATER AIR SOIL POLL JI Water Air Soil Pollut. PD JUN PY 2014 VL 225 IS 6 AR 2001 DI 10.1007/s11270-014-2001-2 PG 11 WC Environmental Sciences; Meteorology & Atmospheric Sciences; Water Resources SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences; Water Resources GA AK3ON UT WOS:000338334200035 ER PT J AU Mehta, N Oyler, K Cheng, G Shah, A Marin, J Yee, K AF Mehta, Neha Oyler, Karl Cheng, Gartung Shah, Akash Marin, John Yee, Kin TI Primary Explosives SO ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE LA English DT Article DE Energetic materials; "Green" explosives; Primary explosives; DBX-1; Lead ID DBX-1 AB Primary explosives, unlike secondary explosives, show a very rapid transition from combustion (or deflagration) to detonation and are considerably sensitive to small stimuli, such as impact, friction, electrostatic discharge, and heat. Primary explosives generate either a large amount of heat or a shockwave, which makes the transfer of the detonation to a less sensitive propellant or secondary explosive possible.[1] Primary explosives are key components in detonators and primers, which are the initiating elements to many military items such as small, medium, and large caliber munitions, mortars, artillery, warheads, etc. The two most common military primary explosives are lead azide and lead styphnate. Lead based compounds such as these have well-established hazards to health and the environment. To overcome these concerns, in common U. S. Army detonators and primers lead azide was replaced with DBX-1 [copper(I) nitrotetrazolate], recently developed by Pacific Scientific Energetic Materials Company and the U. S. Naval Surface Warfare Center at Indian Head. Further, in order to minimize the dangers to personnel and equipment associated with synthesizing and handling primary explosives, a dedicated, remote-operated facility for the synthesis and testing of primary explosives has been developed. C1 [Mehta, Neha; Oyler, Karl; Cheng, Gartung; Shah, Akash; Marin, John; Yee, Kin] US Army RDECOM ARDEC, Explos Dev Branch, Picatinny Arsenal, NJ 07806 USA. RP Mehta, N (reprint author), US Army RDECOM ARDEC, Explos Dev Branch, Picatinny Arsenal, NJ 07806 USA. EM neha.mehta.civ@mail.mil FU RDECOM Environmental Quality Technology Ordnance Environmental Program; PM-JS FX We would like to acknowledge RDECOM Environmental Quality Technology Ordnance Environmental Program and PM-JS for their funding support. We would also like to thank Franklin Engineering, especially Charlie Sturdivant, for his patience in designing the automated systems. Also like to thank Thomas M. Klapotke and his team and Jerry Salan of Nalas Engineering. NR 10 TC 7 Z9 7 U1 5 U2 18 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 0044-2313 EI 1521-3749 J9 Z ANORG ALLG CHEM JI Z. Anorg. Allg. Chem. PD JUN PY 2014 VL 640 IS 7 SI SI BP 1309 EP 1313 DI 10.1002/zaac.201400053 PG 5 WC Chemistry, Inorganic & Nuclear SC Chemistry GA AJ5RW UT WOS:000337746000013 ER PT J AU Drost, RJ Sadler, BM AF Drost, Robert J. Sadler, Brian M. TI Constellation Design for Channel Precompensation in Multi-Wavelength Visible Light Communications SO IEEE TRANSACTIONS ON COMMUNICATIONS LA English DT Article DE Channel precompensation; constellation design; modulation; visible-light communications (VLC) ID EMITTING-DIODES; DISCRETE MULTITONE; MODULATION; SYSTEM AB The predicted ubiquity of light-emitting diodes (LEDs) suggests great potential for dual-use systems with visible light communications (VLC) capabilities. One class of LEDs employs multiple emitters at different wavelengths, making them appropriate for applications requiring colored output and providing multiple channels for communication. We present a design framework for optimizing the signaling constellation of VLC systems employing an arbitrary number of such LEDs, each with an arbitrary number of emitters. In particular, by considering the design of constellation-symbol locations jointly across LED emitters, the framework provides for the precompensation of linear channel distortions arising from, for example, cross-channel leakage, noise correlation, or wavelength-dependent received-signal and/or noise power, as well as the incorporation of design constraints for color-shift keying, dimming, and/or perceived color. Simulation results demonstrate the design approach and the potential performance enhancement that can be achieved for particular system scenarios. Experimental measurements using a prototype VLC system confirm such performance enhancements, providing real-world evidence of the benefit of applying the proposed framework to VLC channel precompensation. C1 [Drost, Robert J.; Sadler, Brian M.] US Army Res Lab, Adelphi, MD 20783 USA. RP Drost, RJ (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM robert.j.drost6.civ@mail.mil; brian.m.sadler6.civ@mail.mil NR 37 TC 10 Z9 10 U1 0 U2 8 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0090-6778 EI 1558-0857 J9 IEEE T COMMUN JI IEEE Trans. Commun. PD JUN PY 2014 VL 62 IS 6 BP 1995 EP 2005 DI 10.1109/TCOMM.2014.2321402 PG 11 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA AJ9KN UT WOS:000338029200020 ER PT J AU Morelli, F Neugebauer, JM LaFiandra, ME Burcham, P Gordon, CT AF Morelli, Frank Neugebauer, Jennifer M. LaFiandra, Michael E. Burcham, Patricia Gordon, Caleb T. TI Recoil Measurement, Mitigation Techniques, and Effects on Small Arms Weapon Design and Marksmanship Performance SO IEEE TRANSACTIONS ON HUMAN-MACHINE SYSTEMS LA English DT Article DE Accelerometers; anthropometry; force measurement; human factors; interactive systems; motion measurement; test equipment ID MAGNETO RHEOLOGICAL DAMPERS AB A methodology to determine the interactive effects of weapon recoil, for both the weapon and the shooter in synchrony during shoulder-fired small arms target engagement scenarios, is yet to be established with widespread applications. Recoil energy can be measured using devices such as instrumented weapon mounts, or calculated from factors such as weapon weight, center of mass, projectile mass, and muzzle velocity. However, the effect of recoil on the shooter will affect shooting performance. Perceived recoil may be defined as a mental representation of the impact intensity experienced by the shooter, a subjective estimation that encompasses pain, discomfort, propensity to flinch, and other factors. Methods to quantify and mitigate the recoil energy experienced by the shooter, as well as proposed concepts for improved recording of the interaction between the physical and psychological correlates of recoil as it relates to small arms shoulder-fired weapon use are discussed. C1 [Morelli, Frank; Neugebauer, Jennifer M.; LaFiandra, Michael E.; Burcham, Patricia; Gordon, Caleb T.] US Army Res Lab, Adelphi, MD 20783 USA. RP Morelli, F (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM frank.morelli.civ@mail.mil; jennifer.neugebauer.ctr@mail.mil; michael.e.lafiandra.civ@mail.mil; patricia.m.burcham.civ@mail.mil; caleb.t.gordon.ctr@us.army.mil NR 26 TC 2 Z9 2 U1 3 U2 8 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 2168-2291 EI 2168-2305 J9 IEEE T HUM-MACH SYST JI IEEE T. Hum.-Mach. Syst. PD JUN PY 2014 VL 44 IS 3 BP 422 EP 428 DI 10.1109/THMS.2014.2301715 PG 7 WC Computer Science, Artificial Intelligence; Computer Science, Cybernetics SC Computer Science GA AJ8NE UT WOS:000337961300012 ER PT J AU Han, SC Castro, F Lee, LO Charney, ME Marx, BP Brailey, K Proctor, SP Vasterling, JJ AF Han, Sohyun C. Castro, Frank Lee, Lewina O. Charney, Meredith E. Marx, Brian P. Brailey, Kevin Proctor, Susan P. Vasterling, Jennifer J. TI Military unit support, postdeployment social support, and PTSD symptoms among active duty and National Guard soldiers deployed to Iraq SO JOURNAL OF ANXIETY DISORDERS LA English DT Article DE Social support; Unit support; Posttraumatic stress disorder; Military personnel; Deployment; Longitudinal ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS; RISK-FACTORS; LIFE EVENTS; RESILIENCE; PERSONNEL; VETERANS; EXPLANATIONS; AFGHANISTAN; EXPERIENCES AB Research suggests that military unit support and community postdeployment social support are associated with fewer PTSD symptoms following military deployment. This study extended prior research by examining the associations among predeployment unit support and PTSD symptoms before Iraq deployment as well as unit support, PTSD symptoms, and postdeployment social support after deployment among 835 U.S. Army and 173 National Guard soldiers. Multiple regression analyses indicated that predeployment unit support was not significantly associated with postdeployment PTSD severity in either group of soldiers, whereas higher unit support during deployment was significantly associated with lower postdeployment PTSD severity among active duty soldiers only. Among both groups, higher levels of postdeployment social support were associated with lower levels of postdeployment PTSD symptom severity. These findings suggest that postdeployment social support is a particularly strong buffer against postdeployment PTSD symptoms among both groups of soldiers whereas the effects of unit support may be limited. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Han, Sohyun C.; Castro, Frank; Lee, Lewina O.; Marx, Brian P.; Proctor, Susan P.; Vasterling, Jennifer J.] VA Boston Healthcare Syst, Natl Ctr PTSD, Boston, MA 02130 USA. [Charney, Meredith E.; Brailey, Kevin] VA Boston Healthcare Syst, Boston, MA 02130 USA. [Lee, Lewina O.; Marx, Brian P.; Brailey, Kevin; Vasterling, Jennifer J.] Boston Univ, Sch Med, Boston, MA 02118 USA. [Proctor, Susan P.] US Army Res Inst Environm Med, Natick, MA USA. [Lee, Lewina O.; Proctor, Susan P.] Boston Univ, Sch Publ Hlth, Boston, MA 02118 USA. RP Vasterling, JJ (reprint author), VA Boston Healthcare Syst 116B 4, 150 South Huntington Ave, Boston, MA 02130 USA. EM jennifer.vasterling@va.gov FU NIA NIH HHS [AG032037, AG039343] NR 31 TC 6 Z9 6 U1 3 U2 18 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0887-6185 EI 1873-7897 J9 J ANXIETY DISORD JI J. Anxiety Disord. PD JUN PY 2014 VL 28 IS 5 BP 446 EP 453 DI 10.1016/j.janxdis.2014.04.004 PG 8 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA AJ8WS UT WOS:000337989400003 PM 24846492 ER PT J AU Jones, KF Thompson, G Claffey, KJ Kelsey, EP AF Jones, Kathleen F. Thompson, Gregory Claffey, Keran J. Kelsey, Eric P. TI Gamma Distribution Parameters for Cloud Drop Distributions from Multicylinder Measurements SO JOURNAL OF APPLIED METEOROLOGY AND CLIMATOLOGY LA English DT Article ID PART I; MICROPHYSICS PARAMETERIZATION; EXPLICIT FORECASTS AB The liquid water content and drop diameters in supercooled clouds have been measured since the 1940s at the summit of Mount Washington in New Hampshire using a rotating multicylinder. Many of the cloud microphysics models in the Weather Research and Forecasting Model (WRF) assume a gamma distribution for cloud drops. In this paper, years of multicylinder data are reanalyzed to determine the best-fitting gamma or monodisperse distribution to compare with parameters in the WRF cloud models. The single-moment cloud schemes specify a predetermined and constant drop number density in clouds, which leads to a fixed relationship between the median volume drop diameter and the liquid water content. The Mount Washington drop number densities are generally larger and best-fit distributions are generally narrower than is typically assumed in WRF. C1 [Jones, Kathleen F.; Claffey, Keran J.] US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Thompson, Gregory] Natl Ctr Atmospher Res, Boulder, CO 80307 USA. [Kelsey, Eric P.] Mt Washington Observ, North Conway, NH USA. RP Jones, KF (reprint author), US Army, Cold Reg Res & Engn Lab, Terr & Cryospher Sci Branch, 72 Lyme Rd, Hanover, NH 03755 USA. EM kathleen.f.jones@usace.army.mil FU U.S. Army Corps of Engineers Engineer Research and Development Center Geospatial Research and Engineering business area work unit "Geoenabled Multimodal Situational Awareness"; Plymouth State University FX Authors Jones and Claffey were supported by the U.S. Army Corps of Engineers Engineer Research and Development Center Geospatial Research and Engineering business area work unit "Geoenabled Multimodal Situational Awareness" and a Cooperative Research and Development Agreement with Plymouth State University. We thank the anonymous reviewers for their useful suggestions. NR 17 TC 1 Z9 1 U1 1 U2 6 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1558-8424 EI 1558-8432 J9 J APPL METEOROL CLIM JI J. Appl. Meteorol. Climatol. PD JUN PY 2014 VL 53 IS 6 BP 1606 EP 1617 DI 10.1175/JAMC-D-13-0306.1 PG 12 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA AJ5YT UT WOS:000337767400017 ER PT J AU Poropatich, RK Pavliscsak, HH Tong, JC Little, JR McVeigh, FL AF Poropatich, Ronald K. Pavliscsak, Holly H. Tong, James C. Little, Jeanette R. McVeigh, Francis L. TI mCare: Using Secure Mobile Technology to Support Soldier Reintegration and Rehabilitation SO TELEMEDICINE AND E-HEALTH LA English DT Article DE health; military medicine; information management; rehabilitation; telecommunications ID TRAUMATIC BRAIN-INJURY AB Background: The U. S. Army Medical Department conducted a pilot mobile health project to determine the requirements for coordination of care for "Wounded Warriors'' using mobile messaging. The primary objective was to determine if a secure mobile health (mhealth) intervention provided to geographically dispersed patients would improve contact rates and positively impact the military healthcare system. Methods and Materials: Over 21 months, volunteers enrolled in a Health Insurance Portability and Accountability Act-compliant, secure mobile messaging initiative called mCare. The study included males and females, 18-61 years old, with a minimum of 60 days of outpatient recovery. Volunteers were required to have a compatible phone. The mhealth intervention included appointment reminders, health and wellness tips, announcements, and other relevant information to this population exchanged between care teams and patients. Results: Provider respondents reported that 85% would refer patients to mCare, and 56% noted improvement in appointment attendance (n = 90). Patient responses also revealed high acceptability of mCare and refined the frequency and delivery times (n = 114). The pilot project resulted in over 84,000 outbound messages and improved contact rates by 176%. Conclusions: The mCare pilot project demonstrated the feasibility and administrative effectiveness of a scalable mhealth application using secure mobile messaging and information exchanges, including personalized patient education. C1 [Poropatich, Ronald K.] Univ Pittsburgh, Ctr Mil Med Res, Pittsburgh, PA USA. [Pavliscsak, Holly H.; Little, Jeanette R.] US Army Med Res & Mat Command USAMRMC, Telemed & Adv Technol Res Ctr TATRC, Ft Gordon, GA 30905 USA. [Tong, James C.] PricewaterhouseCoopers LLP, Herndon, VA USA. [McVeigh, Francis L.] US Army Med Res & Mat Command, Telemed & Adv Technol Ctr, Ft Detrick, MD USA. RP Pavliscsak, HH (reprint author), US Army Med Res & Mat Command USAMRMC, Mobile Hlth Innovat Ctr MHIC, Telemed & Adv Technol Res Ctr TATRC, mCare Project, Bldg 38711, Ft Gordon, GA 30905 USA. EM holly.h.pavliscsak.ctr@mail.mil NR 15 TC 3 Z9 3 U1 1 U2 12 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-5627 EI 1556-3669 J9 TELEMED E-HEALTH JI Telemed. e-Health PD JUN PY 2014 VL 20 IS 6 BP 563 EP 569 DI 10.1089/tmj.2013.0226 PG 7 WC Health Care Sciences & Services SC Health Care Sciences & Services GA AJ8IA UT WOS:000337945500010 PM 24666038 ER PT J AU Pissani, F Streeck, H AF Pissani, Franco Streeck, Hendrik TI Emerging concepts on T follicular helper cell dynamics in HIV infection SO TRENDS IN IMMUNOLOGY LA English DT Review DE follicular B helper T cell; HIV; HIV neutralizing antibody; broadly neutralizing antibody; peripheral blood T follicular helper T cell (pTfh); vaccine T follicular helper cells ID CHRONIC VIRAL-INFECTION; CENTER B-CELL; LIVED PLASMA-CELLS; GERMINAL CENTER; NEUTRALIZING ANTIBODIES; MONOCLONAL-ANTIBODIES; C-MAF; RESPONSES; VIRUS; BROAD AB Inducing cross-reactive broadly neutralizing antibody (bNAb) responses to HIV through vaccination remains an insurmountable challenge. T follicular helper (T-FH) cells are fundamental for the development of antigen-specific antibody responses and therefore crucial for anti-HIV vaccine design. Here, we review recent studies supporting an intricate involvement of T-FH cells in HIV pathogenesis and bNAb development during HIV infection. We also examine emerging data suggesting that T-FH cell responses may be traceable in peripheral blood, and discuss the implications of these findings in the context of vaccine design and future research in T-FH cell immunobiology. C1 [Pissani, Franco; Streeck, Hendrik] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Pissani, Franco; Streeck, Hendrik] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. RP Streeck, H (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. EM hstreeck@hivresearch.org FU US National Institutes of Health (NIH) [R01 AI091450-01, R01 AI094602-01]; U.S. Department of Defense (DOD); [W81XWH-07-2-0067] FX We apologize to those whose work is not mentioned in this review due to space limitations. This study was funded by the US National Institutes of Health (NIH) (R01 AI091450-01 and R01 AI094602-01) and a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD). NR 78 TC 11 Z9 12 U1 1 U2 12 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1471-4906 EI 1471-4981 J9 TRENDS IMMUNOL JI Trends Immunol. PD JUN PY 2014 VL 35 IS 6 BP 278 EP 286 DI 10.1016/j.it.2014.02.010 PG 9 WC Immunology SC Immunology GA AJ7MO UT WOS:000337881000007 PM 24703588 ER PT J AU Cooper, C Sutorik, AC Wright, J Luoto, EA Gilde, G Wolfenstine, J AF Cooper, Christopher Sutorik, Anthony C. Wright, Jared Luoto, E. Arthur, III Gilde, Gary Wolfenstine, Jeff TI Mechanical Properties of Hot Isostatically Pressed Li0.35La0.55TiO3 SO ADVANCED ENGINEERING MATERIALS LA English DT Article ID LITHIUM LANTHANUM TITANATES; IONIC-CONDUCTIVITY; AIR BATTERIES; SOLID-STATE; LI-AIR; ELECTROLYTE; CERAMICS; LI0.33LA0.57TIO3 C1 [Cooper, Christopher; Sutorik, Anthony C.; Wright, Jared; Luoto, E. Arthur, III; Gilde, Gary] US Army Res Lab, RDRL WMM E, Aberdeen Proving Ground, MD 21005 USA. [Wolfenstine, Jeff] US Army Res Lab, RDRL SED C, Adelphi, MD 20783 USA. RP Cooper, C (reprint author), US Army Res Lab, RDRL WMM E, Bldg 4600, Aberdeen Proving Ground, MD 21005 USA. EM jeffrey.b.wolfenstine.civ@mail.mil NR 25 TC 1 Z9 1 U1 5 U2 28 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 1438-1656 EI 1527-2648 J9 ADV ENG MATER JI Adv. Eng. Mater. PD JUN PY 2014 VL 16 IS 6 SI SI BP 755 EP 759 DI 10.1002/adem.201400071 PG 5 WC Materials Science, Multidisciplinary SC Materials Science GA AJ4HQ UT WOS:000337635500011 ER PT J AU Pugh, C Keasey, S Korman, L Pittman, PR Ulrich, RG AF Pugh, Christine Keasey, Sarah Korman, Lawrence Pittman, Phillip R. Ulrich, Robert G. TI Human Antibody Responses to the Polyclonal Dryvax Vaccine for Smallpox Prevention Can Be Distinguished from Responses to the Monoclonal Replacement Vaccine ACAM2000 SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID POXVIRUS ORTHOLOGOUS CLUSTERS; SURFACE HEPARAN-SULFATE; HUMAN IMMUNE-RESPONSE; SINGLE-STRANDED-DNA; 2 INFECTIOUS FORMS; INTRACELLULAR MATURE; CELL-SURFACE; VIRUS ENVELOPE; BINDING-PROTEIN; EXTRACELLULAR DOMAIN AB Dryvax (Wyeth Laboratories, Inc., Marietta, PA) is representative of the vaccinia virus preparations that were previously used for preventing smallpox. While Dryvax was highly effective, the national supply stocks were depleted, and there were manufacturing concerns regarding sterility and the clonal heterogeneity of the vaccine. ACAM2000 (Acambis, Inc./Sanofi-Pasteur Biologics Co., Cambridge, MA), a single-plaque-purified vaccinia virus derivative of Dryvax, recently replaced the polyclonal smallpox vaccine for use in the United States. A substantial amount of sequence heterogeneity exists within the polyclonal proteome of Dryvax, including proteins that are missing from ACAM2000. Reasoning that a detailed comparison of antibody responses to the polyclonal and monoclonal vaccines may be useful for identifying unique properties of each antibody response, we utilized a protein microarray comprised of approximately 94% of the vaccinia poxvirus proteome (245 proteins) to measure protein-specific antibody responses of 71 individuals receiving a single vaccination with ACAM2000 or Dryvax. We observed robust antibody responses to 21 poxvirus proteins in vaccinated individuals, including 11 proteins that distinguished Dryvax responses from ACAM2000. Analysis of protein sequences from Dryvax clones revealed amino acid level differences in these 11 antigenic proteins and suggested that sequence variation and clonal heterogeneity may contribute to the observed differences between Dryvax and ACAM2000 antibody responses. C1 [Pugh, Christine; Keasey, Sarah; Korman, Lawrence; Pittman, Phillip R.; Ulrich, Robert G.] US Army Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Ulrich, RG (reprint author), US Army Med Res Inst Infect Dis, Frederick, MD 21702 USA. EM rulrich@bhsai.org FU Military Vaccine Agency, Office of the Surgeon General, United States Army; Student Research Participation Program at the U.S. Army Medical Research Institute of Infectious Disease FX This research was supported in part by an appointment of C.P. and S.K. to the Student Research Participation Program at the U.S. Army Medical Research Institute of Infectious Disease administered by Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USAMRMC. This clinical study was sponsored by the Military Vaccine Agency, Office of the Surgeon General, United States Army. NR 89 TC 2 Z9 2 U1 3 U2 9 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 EI 1556-679X J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD JUN PY 2014 VL 21 IS 6 BP 877 EP 885 DI 10.1128/CVI.00035-14 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AJ0NW UT WOS:000337352500014 PM 24759651 ER PT J AU Shaffer, D Hughes, MD Sawe, F Bao, YJ Moses, A Hogg, E Lockman, S Currier, J AF Shaffer, Douglas Hughes, Michael D. Sawe, Fredrick Bao, Yajing Moses, Agnes Hogg, Evelyn Lockman, Shahin Currier, Judith TI Cardiovascular Disease Risk Factors in HIV-Infected Women After Initiation of Lopinavir/Ritonavir- and Nevirapine-Based Antiretroviral Therapy in Sub-Saharan Africa: A5208 (OCTANE) SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE HIV-1; women; Africa; nevirapine; lopinavir; ritonavir; cardiovascular disease risk factors ID IMMUNODEFICIENCY-VIRUS-INFECTION; ISCHEMIC-HEART-DISEASE; MYOCARDIAL-INFARCTION; PROTEASE INHIBITORS; NONFASTING TRIGLYCERIDES; EVENTS; COHORT; LIPIDS; AIDS; MEN AB Background:Limited comparative, prospective data exist regarding cardiovascular risk factors in HIV-infected women starting antiretroviral therapy in Africa.Methods:In 7 African countries, 741 women with CD4 <200 cells/mm(3) were randomized to tenofovir/emtricitabine (TDF/FTC) plus either nevirapine (NVP, n = 370) or lopinavir/ritonavir (LPV/r, n = 371). Lipids and blood pressure (BP) were evaluated at entry, 48, 96, and 144 weeks. Multivariable linear and logistic regression models were used to evaluate mean risk factor changes and clinically relevant risk factor changes.Results:At entry, both NVP and LPV/r groups were similar regarding age [mean = 33.5 (SD = 7.1) years], CD4 [129 (67) cells/mm(3)], and HIV-1 RNA [5.1 (0.6) log(10) copies/mL]. Nearly, all women had normal lipids and BP except for high-density lipoprotein (HDL)-cholesterol. Over 144 weeks, the LPV/r compared with NVP group had significantly greater mean lipid increases (eg, non-HDL: +29 vs. +13 mg/dL) and smaller HDL increases (+12 vs. +21 mg/dL). In contrast, the NVP compared with LPV/r group had greater mean increases in BP (eg, diastolic BP: +5 vs. -0.5 mm Hg). Significantly, more women assigned LPV/r had week 144 abnormal lipid levels (eg, HDL 29.7% vs. 14.8% and triglycerides 28.6% vs. 8.2%), and significantly, more women assigned NVP had abnormal BP (eg, diastolic BP 22.7% vs. 6.5%). Most differences remained significant when adjusted for baseline risk factor, age, CD4, and HIV-1 RNA.Conclusions:In HIV-infected women initiating antiretroviral therapy in Africa, LPV/r + TDF/FTC was associated with less favorable changes in lipids, and use of NVP + TDF/FTC was associated with less favorable changes in BP. C1 [Shaffer, Douglas; Sawe, Fredrick] Kenya Govt Med Res Ctr, Walter Reed Project, Kericho, Kenya. [Shaffer, Douglas; Sawe, Fredrick] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Hughes, Michael D.; Bao, Yajing; Lockman, Shahin] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA. [Sawe, Fredrick] Henry M Jackson Fdn Adv Mil Med, Rockville, MD USA. [Moses, Agnes] Univ North Carolina Project, Kamuzu Cent Hosp, Lilongwe, Malawi. [Hogg, Evelyn] Social & Sci Syst Inc, Silver Spring, MD USA. [Lockman, Shahin] Brigham & Womens Hosp, Boston, MA 02115 USA. [Lockman, Shahin] Botswana Harvard Sch Publ Hlth AIDS Initiat Partn, Gaborone, Botswana. [Currier, Judith] Univ Calif Los Angeles, Los Angeles, CA USA. RP Shaffer, D (reprint author), US Embassy, Ctr Dis Control & Prevent CDC, 2657 Ave Gendarmerie,POB 28, Kigali, Rwanda. EM DShaffer@cdc.gov FU National Institute of Allergy and Infectious Diseases [U01AI068636, AI38838]; Statistical and Data Management Center, National Institute of Allergy and Infectious Diseases [AI68634]; General Clinical Research Center Units - National Center for Research; National Institute of Allergy and Infectious Diseases-US Army Medical Research and Material Command IAA [IAAY1AI8374]; UNC Project, Kamuzu Central Hospital; Lilongwe CTU Grant [5 U01 AI069518]; [K24 AI56933] FX Supported in part by grants (U01AI068636, AI38838, and Statistical and Data Management Center AI68634) from the National Institute of Allergy and Infectious Diseases to the AIDS Clinical Trials Group. Supported in part by the General Clinical Research Center Units funded by the National Center for Research. D. S. and F. S. as part of the US Military HIV Research Unit Clinical Trials Unit are supported through the National Institute of Allergy and Infectious Diseases-US Army Medical Research and Material Command IAA (#IAAY1AI8374). A. M. is supported through the UNC Project, Kamuzu Central Hospital; Lilongwe (Site 12001) CTU Grant #5 U01 AI069518. J.C. is supported in part by K24 AI56933. NR 41 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD JUN 1 PY 2014 VL 66 IS 2 BP 155 EP 163 DI 10.1097/QAI.0000000000000131 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AJ4YJ UT WOS:000337685800017 PM 24562349 ER PT J AU Chun, HM Mesner, O Thio, CL Bebu, I Macalino, G Agan, BK Bradley, WP Malia, J Peel, SA Jagodzinski, LL Weintrob, AC Ganesan, A Bavaro, M Maguire, JD Landrum, ML AF Chun, Helen M. Mesner, Octavio Thio, Chloe L. Bebu, Ionut Macalino, Grace Agan, Brian K. Bradley, William P. Malia, Jennifer Peel, Sheila A. Jagodzinski, Linda L. Weintrob, Amy C. Ganesan, Anuradha Bavaro, Mary Maguire, Jason D. Landrum, Michael L. CA Infect Dis Clinical Res Program HI TI HIV Outcomes in Hepatitis B Virus Coinfected Individuals on HAART SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE hepatitis B virus; chronic hepatitis B; HIV; highly active antiretroviral therapy ID HUMAN-IMMUNODEFICIENCY-VIRUS; ACTIVE ANTIRETROVIRAL THERAPY; INFECTED PATIENTS; RAPID PROGRESSION; NATURAL-HISTORY; HOMOSEXUAL-MEN; COHORT; AIDS; PREVALENCE; RISK AB Background:Understanding the impact of hepatitis B virus (HBV) coinfection on HIV outcomes in the highly active antiretroviral therapy (HAART) era continues to be a critical priority given the high prevalence of coinfection and the potential for impaired immunologic, virologic, and clinical recovery.Methods:Participants from the US Military HIV Natural History Study with an HIV diagnosis on HAART and serologically confirmed HBV infection status at HAART initiation (HI) were classified into 4 HBV infection (HB) groups. HIV virologic, immunologic, and clinical outcomes were evaluated by HB status.Results:Of 2536 HIV-positive HAART recipients, with HBV testing results available to determine HB status in the HI window, HB status at HI was classified as HB negative (n = 1505; 66%), resolved HB (n = 518; 23%), isolated hepatitis B core antigen (n = 139; 6%), or chronic HB (n = 131; 6%). HIV virologic suppression and failure at 6 months or 1 year were not significantly different by HB status. A significantly faster rate of increase in CD4 cell count during the period between 4 and 12 years was observed for chronic HB relative to HB negative. Chronic and resolved HB were associated with an increased risk of AIDS/death compared with HB-negative individuals (chronic HBhazard ratio = 1.68, 95% confidence interval: 1.05 to 2.68; resolved HBhazard ratio = 1.61, 95% confidence interval: 1.15 to 2.25).Conclusions:HB status did not have a significant impact on HIV virologic outcomes, however, CD4 cell count reconstitution after HI and the risk of an AIDS event or death after HI may be associated with HB status. C1 [Chun, Helen M.; Mesner, Octavio; Bebu, Ionut; Macalino, Grace; Agan, Brian K.; Bradley, William P.; Malia, Jennifer; Peel, Sheila A.; Jagodzinski, Linda L.; Weintrob, Amy C.; Ganesan, Anuradha; Bavaro, Mary; Maguire, Jason D.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Thio, Chloe L.] Johns Hopkins Univ, Div Infect Dis, Baltimore, MD USA. [Malia, Jennifer; Peel, Sheila A.; Jagodzinski, Linda L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Weintrob, Amy C.; Ganesan, Anuradha] Walter Reed Natl Mil Med Ctr, Div Infect Dis, Bethesda, MD USA. [Bavaro, Mary] Naval Med Ctr, Infect Dis Clin, San Diego, CA USA. [Maguire, Jason D.] Naval Med Ctr, Div Infect Dis, Portsmouth, VA USA. [Landrum, Michael L.] Bellin Hlth Green Bay & Clin Hispana, Green Bay, WI USA. RP Chun, HM (reprint author), Infect Dis Clin Res Program, 11300 Rockville Pike,Suite 600, North Bethesda, MD 20852 USA. EM vgi2@cdc.gov OI Agan, Brian/0000-0002-5114-1669 FU Infectious Diseases Clinical Research Program (IDCRP); DoD through Uniformed Services University of the Health Sciences; National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) [Y1-AI-5072] FX Supported by the Infectious Diseases Clinical Research Program (IDCRP, www.idcrp.org), a DoD program executed through Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072. The IDCRP reviewed the study design, collected the data, and provided salary support to investigators (M.L.L., A.C.W., A.G., and B.K.A.). The analyses, conclusions, and decision to submit the article are the independent work and decision of the authors. NR 36 TC 8 Z9 8 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD JUN 1 PY 2014 VL 66 IS 2 BP 197 EP 205 DI 10.1097/QAI.0000000000000142 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AJ4YJ UT WOS:000337685800023 PM 24694929 ER PT J AU Minogue, TD Kalina, WV Coyne, SR AF Minogue, Timothy Devin Kalina, Warren Vincent Coyne, Susan Rajnik TI Stabilization of biothreat diagnostic samples through vitrification matrices SO JOURNAL OF MICROBIOLOGICAL METHODS LA English DT Article DE CloneStable; RNAStable; Yersina; Venezuelan Equine Encephalitis ID POLYMERASE CHAIN-REACTION; VIRAL-RNA; STORAGE; VIRUS; PCR; PLATFORMS; AGENTS AB Diagnostics for biothreat agents require sample shipment to reference labs for diagnosis of disease; however high/fluctuating temperatures during sample transport negatively affect sample quality and results. Vitrification additives preserve sample integrity for molecular-based assay diagnostics in the absence of refrigeration by imparting whole molecule stability to a plethora of environmental insults. Therefore, we have evaluated commercially available vitrification matrices' (Biomatrica's CloneStable (R) and RNAStable (R)) ability to stabilize samples of Yersinia pestis and Venezuelan Equine Encephalitis Virus. When heated to 95 degrees C in RNAStable (R), Y. pestis had a 13-fold improvement in detection via real-time PCR compared to heated samples in buffer. VEEV, in RNAStable (R) at 55 degrees C, had a similar to 10-fold improved detection versus heated samples in buffer. CloneStable (R) also preserved Y. pestis antigens for 7 days after exposure to cycling temperatures. Overall, RNAStable (R) and CloneStable (R) respectively offered superior stabilization to nucleic acids and proteins in response to temperature fluctuations. (C) 2014 Published by Elsevier B.V. C1 [Minogue, Timothy Devin; Kalina, Warren Vincent; Coyne, Susan Rajnik] US Army, Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. RP Minogue, TD (reprint author), US Army, Res Inst Infect Dis, Diagnost Syst Div, 1425 Porter St, Ft Detrick, MD 21702 USA. EM timothy.d.minogue.civ@mail.mil FU Joint Science & Technology Office for Chemical & Biological Defense [CB3901] FX This work was supported by the Joint Science & Technology Office for Chemical & Biological Defense under Grant No. CB3901. Opinions, interpretations, conclusions, and recommendation are those of the author and are not necessarily endorsed by the U.S. Army. NR 24 TC 0 Z9 0 U1 0 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-7012 EI 1872-8359 J9 J MICROBIOL METH JI J. Microbiol. Methods PD JUN PY 2014 VL 101 BP 81 EP 85 DI 10.1016/j.mimet.2014.04.002 PG 5 WC Biochemical Research Methods; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA AJ4PW UT WOS:000337659300013 PM 24742968 ER PT J AU Penn-Barwell, JG Murray, CK Wenke, JC AF Penn-Barwell, Jowan G. Murray, Clinton K. Wenke, Joseph C. TI Local Antibiotic Delivery by a Bioabsorbable Gel Is Superior to PMMA Bead Depot in Reducing Infection in an Open Fracture Model SO JOURNAL OF ORTHOPAEDIC TRAUMA LA English DT Article DE open fracture; wounds and injuries; infection; antibiotics; local antibiotics; antibiotic beads; bacteria ID GENTAMICIN-COLLAGEN SPONGE; PRESSURE WOUND THERAPY; CHRONIC OSTEOMYELITIS; COMPOUND FRACTURES; TIBIAL FRACTURES; SEGMENTAL DEFECT; DEEP INFECTION; BONE-FORMATION; CEMENT BEADS; LONG-TERM AB Objectives: Local delivery allows a high concentration of antibiotics to be achieved in the wound while avoiding the side effects and cost of systemic administration. Beads molded from polymethylmethacrylate cement are commonly used for local antibiotic delivery but are not ideal. The purpose of this study was to determine whether a bioabsorbable gel delivering vancomycin and gentamicin is more effective in reducing infection than beads delivering vancomycin and tobramycin. Methods: This study used a segmental defect rat model contaminated with Staphylococcus aureus and treated with clinically relevant local antibiotic doses, delivered by gel or beads. In the gel group, 1 mL of gel containing gentamicin and vancomycin was spread throughout the wound. In the bead group, four 3-mm beads containing tobramycin and vancomycin were placed in the wound, 2 in the defect and 2 in the adjacent tissue envelope, there was also a control group that received no antibiotic treatment. After 14 days, bone and hardware was harvested for separate microbiological analysis. Results: There was a significantly lower infection rate in groups treated with antibiotics delivered by gel compared with those treated with either antibiotic beads or no antibiotics at all (P < 0.001). Quantitative cultures also demonstrate significantly less bacteria in the wounds treated with the gel than in the control or bead groups (P <= 0.004). Conclusions: These results suggest that antibiotic delivery by a gel is superior to beads. The authors propose that antibiotic depot by polymethylmethacrylate antibiotic beads is less effective because this method has to rely on diffusion of the antibiotic from the high concentration close to the beads to all regions of the wound. C1 [Penn-Barwell, Jowan G.; Wenke, Joseph C.] US Army Inst Surg Res, San Antonio, TX USA. [Penn-Barwell, Jowan G.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham B15 2SQ, W Midlands, England. [Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis Serv, San Antonio, TX USA. RP Penn-Barwell, JG (reprint author), Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham B15 2SQ, W Midlands, England. EM jowan@doctors.net.uk NR 34 TC 11 Z9 12 U1 0 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0890-5339 EI 1531-2291 J9 J ORTHOP TRAUMA JI J. Orthop. Trauma PD JUN PY 2014 VL 28 IS 6 BP 370 EP 375 PG 6 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA AJ5AM UT WOS:000337692600017 PM 23948961 ER PT J AU Knox, J Schneider, J Wimberly, RL Riccio, AI AF Knox, Jeffrey Schneider, John Wimberly, Robert L. Riccio, Anthony I. TI Characteristics of Spinal Injuries Secondary to Nonaccidental Trauma SO JOURNAL OF PEDIATRIC ORTHOPAEDICS LA English DT Article DE nonaccidental trauma; pediatric spine fracture; cervical spine ID CHILD-ABUSE; CERVICAL-SPINE; PEDIATRIC SPINE; FRACTURES; CORD; PATTERNS AB Background: Nonaccidental trauma (NAT) is considered an uncommon cause of spine trauma in the pediatric population. Little has been published on such injuries and no large series is available in the literature. The purpose of this study is to describe the incidence and characteristics of spine trauma secondary to NAT. Methods: An IRB-approved retrospective review of all patients presenting to a single level 1 pediatric trauma center with a spinal injury between 2003 and 2011 was performed. Patients were identified using our institution's trauma registry. Medical records were reviewed to identify all spine injuries that occurred as a result of NAT. These cases were reviewed for details regarding injury mechanism, type and location of injury, associated injuries, and the treatment. Our institution's NAT database was also queried to identify the total number of patients formally determined to have sustained any injury as a result of NAT during the same period. Results: NAT was the cause of 11/342 (3.2%) spine injuries diagnosed during the study period. A total of 726 cases of NAT were identified, with spine injury present in 1.5%. All patients with spine trauma secondary to NAT were under the age of 2 years with an average age of 7 months. Among patients below 2 years with spinal trauma, NAT was tied as the most common mechanism, resulting in 38% of injuries. Eight of the 11 patients' spine injuries were cervical and 7 of these injuries were in the atlanto-occipital and atlantoaxial regions. Multilevel spine trauma was present in 64% of patients. Associated head and thoracic trauma was present in 73% and 36% of patients, respectively. Neurological injury was found in 54% of patients. The majority of injuries were treated nonoperatively and 1 patient required surgical management. Conclusions: NAT represents a very common yet often overlooked cause of spinal trauma in children under the age of 2 years. Because of its frequency in this age group, clinicians should consider including an assessment of the spine in all young NAT patients. Patients with spinal trauma sustained as a result of NAT must undergo a thorough evaluation for associated injuries remote to the spine, neurological deficit, and multilevel spine injury. Summary: NAT is a common mechanism of spinal injury in patients below 2 years of age. C1 [Knox, Jeffrey] Tripler Army Med Ctr, Orthoped Surg Serv, Honolulu, HI 96859 USA. [Schneider, John] Univ Texas SW Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USA. [Schneider, John; Wimberly, Robert L.; Riccio, Anthony I.] Childrens Med Ctr, Dallas, TX 75235 USA. [Wimberly, Robert L.; Riccio, Anthony I.] Texas Scottish Rite Hosp Children, Dept Orthoped, Dallas, TX 75235 USA. RP Riccio, AI (reprint author), Texas Scottish Rite Hosp Children, Dept Orthoped, Dallas, TX 75235 USA. EM anthony.riccio@childrens.com NR 24 TC 7 Z9 7 U1 0 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0271-6798 EI 1539-2570 J9 J PEDIATR ORTHOPED JI J. Pediatr. Orthop. PD JUN PY 2014 VL 34 IS 4 BP 376 EP 381 PG 6 WC Orthopedics; Pediatrics SC Orthopedics; Pediatrics GA AJ5RQ UT WOS:000337745100002 PM 24172665 ER PT J AU Danabalan, R Monaghan, MT Ponsonby, DJ Linton, YM AF Danabalan, R. Monaghan, M. T. Ponsonby, D. J. Linton, Y. -M. TI Occurrence and host preferences of Anopheles maculipennis group mosquitoes in England and Wales SO MEDICAL AND VETERINARY ENTOMOLOGY LA English DT Article DE Anopheles atroparvus; Anopheles daciae; Anopheles messeae; bloodmeal; host preference; ITS-2; PCR-RFLP assay; U; K ID POLYMERASE-CHAIN-REACTION; COMPLEX DIPTERA; SPECIES DIPTERA; RIBOSOMAL DNA; CULICIDAE; MALARIA; IDENTIFICATION; BEKLEMISHEVI; RECOGNITION; BLOODMEALS AB Mosquitoes of the Anopheles maculipennis Meigen (Diptera: Culicidae) group are of public health concern: five of the 11 morphologically indistinct species have been historically considered as vectors of malaria in Europe. Three members of the An.maculipennis group have been reported in the U.K.: Anopheles atroparvus van Thiel; Anopheles messeae Falleroni, and Anopheles daciae Linton, Nicolescu & Harbach. To study the distribution of the three U.K. species, particularly that of An.daciae, we developed a polymerase chain reaction-Restriction fragment length polymorphism (PCR-RFLP) assay using the nuclear ribosomal internal transcribed spacer 2 (ITS-2) gene. Anopheles daciae was found to be widespread, occurring in four of the five counties surveyed in southern England and on the Welsh island of Anglesey, often in sympatry with the closely related species An.messeae. The host preferences of 237 blood-fed females were determined using either direct sequencing or PCR-based fragment analysis of the mitochondrial cytochrome oxidase b gene with DNA from females' abdomens. All three species were found to be opportunistic, having fed on at least three different hosts. Seventeen individuals contained multiple bloodmeals, including two An.daciae that had fed on humans and birds. Our results show that An.daciae is widespread in England and Wales, occurs in sympatry with other members of the An.maculipennis group, and feeds on humans, which suggests it is a potential vector of disease in the U.K. C1 [Danabalan, R.] Museum Nat Kunde, Dept Res, D-10115 Berlin, Germany. [Danabalan, R.; Ponsonby, D. J.] Canterbury Christ Church Univ, Dept Geog & Life Sci, Canterbury, Kent, England. [Danabalan, R.; Linton, Y. -M.] Nat Hist Museum, Dept Entomol, London SW7 5BD, England. [Monaghan, M. T.] Leibniz Inst Freshwater Ecol & Inland Fisheries, Berlin, Germany. [Linton, Y. -M.] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD USA. RP Danabalan, R (reprint author), Museum Nat Kunde, Dept Res, Invalidenstr 43, D-10115 Berlin, Germany. EM Renita.Danabalan@mfn-berlin.de RI Monaghan, Michael/A-2589-2009 OI Monaghan, Michael/0000-0001-6200-2376 FU Canterbury Christ Church University; Natural History Museum in London FX This study formed part of the PhD thesis of RD and was funded through a PhD studentship from Canterbury Christ Church University awarded to RD, DJP and YML. Field collections were funded by the Natural History Museum in London (to YML). Field collections were carried out with some assistance from Magdalena Zarowiecki. The authors are extremely grateful to all landowners, the Royal Society for the Protection of Birds (Exminster Marshes) and the staff of Pettitts Animal Adventure Park for allowing mosquito collections to take place on their properties. This manuscript was prepared whilst YML held a National Research Council Research Associateship Award at the Walter Reed Army Institute of Research. This material reflects the views of the authors and should not be construed as representing those of the U.S. Department of the Army or the U.S. Department of Defense. NR 52 TC 7 Z9 8 U1 3 U2 16 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0269-283X EI 1365-2915 J9 MED VET ENTOMOL JI Med. Vet. Entomol. PD JUN PY 2014 VL 28 IS 2 BP 169 EP 178 DI 10.1111/mve.12023 PG 10 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA AJ3ND UT WOS:000337572500006 PM 23848304 ER PT J AU Kahl, C Gfoeller, M Katz, MN Kimmitt, MT AF Kahl, Colin Gfoeller, Michael Katz, Mark N. Kimmitt, Mark T. TI Symposium: US Commitments to the Gulf Arab States: Are They Adequate? SO MIDDLE EAST POLICY LA English DT Editorial Material C1 [Kahl, Colin] Georgetown Univ, Washington, DC 20057 USA. [Kahl, Colin] Ctr New Amer Security, Middle East Secur Program, Washington, DC USA. [Gfoeller, Michael] Chertoff Grp, Washington, DC USA. [Gfoeller, Michael] ExxonMobil, Int Govt Relat, Middle East & North African Affairs, Irving, TX USA. [Gfoeller, Michael] US Embassy, Riyadh, Saudi Arabia. [Katz, Mark N.] George Mason Univ, Fairfax, VA 22030 USA. [Katz, Mark N.] US Dept State, Washington, DC USA. [Kimmitt, Mark T.] US Army, Washington, DC USA. RP Kahl, C (reprint author), Georgetown Univ, Washington, DC 20057 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1061-1924 EI 1475-4967 J9 MIDDLE EAST POLICY JI Middle East Policy PD SUM PY 2014 VL 21 IS 2 BP 1 EP 33 DI 10.1111/mepo.12067 PG 33 WC Area Studies; International Relations SC Area Studies; International Relations GA AJ3DE UT WOS:000337545000001 ER PT J AU Cap, LCAP AF Cap, Lieutenant Colonel Andrew P. TI The school of hard knocks: what we've learned and relearned about transfusion in a decade of global conflict SO TRANSFUSION MEDICINE LA English DT Editorial Material ID OPERATION ENDURING FREEDOM; COMBAT CASUALTY CARE; FRESH WHOLE-BLOOD; DAMAGE-CONTROL; AEROMEDICAL EVACUATION; IMPROVED SURVIVAL; INCREASED PLASMA; TRAUMA SYSTEMS; MILITARY; WAR C1 [Cap, Lieutenant Colonel Andrew P.] US Army Inst Surg Res, Coagulat & Blood Res Program, San Antonio, TX 78234 USA. RP Cap, LCAP (reprint author), US Army Inst Surg Res, JBSA FT Sam Houston, San Antonio, TX 78234 USA. EM andrew.p.cap.mil@mail.mil NR 30 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0958-7578 EI 1365-3148 J9 TRANSFUSION MED JI Transfus. Med. PD JUN PY 2014 VL 24 IS 3 BP 135 EP 137 DI 10.1111/tme.12127 PG 3 WC Hematology SC Hematology GA AJ3OK UT WOS:000337576100002 ER PT J AU Carra, BJ Bui-Mansfield, LT O'Brien, SD Chen, DC AF Carra, Bradley J. Bui-Mansfield, Liem T. O'Brien, Seth D. Chen, Dillon C. TI Sonography of Musculoskeletal Soft-Tissue Masses: Techniques, Pearls, and Pitfalls SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article DE extremities; musculoskeletal system; soft-tissue mass; sonography; ultrasound ID MOREL-LAVALLEE LESION; SUPERFICIAL MELANOMA METASTASES; COLOR DOPPLER SONOGRAPHY; HIGH-RESOLUTION; PATHOLOGICAL CORRELATION; ADULT PATIENTS; TUMORS; WRIST; US; ULTRASOUND AB OBJECTIVE. The purpose of this article is to review the appropriate use of ultrasound in the workup of soft-tissue masses of the extremities. The normal sonographic appearance of superficial soft tissues, the importance of proper technique in image acquisition, and the characteristic sonographic appearance of certain masses and potential pitfalls are discussed. CONCLUSION. Ultrasound is increasingly being used for the initial evaluation of softtissue masses of the extremities. Certain clinical and imaging findings allow diagnosis of selected soft-tissue masses; however, most imaging findings are nonspecific, and further evaluation is necessary. The many potential pitfalls can lead to adverse patient outcomes. C1 [Carra, Bradley J.] Wilford Hall Ambulatory Surg Ctr, Dept Radiol, Lackland AFB, TX USA. [Carra, Bradley J.; Bui-Mansfield, Liem T.; O'Brien, Seth D.; Chen, Dillon C.] Brooke Army Med Ctr, JBSA, Dept Radiol, Ft Sam Houston, TX 78234 USA. [Bui-Mansfield, Liem T.; O'Brien, Seth D.; Chen, Dillon C.] Uniformed Serv Univ Hlth Sci, Dept Radiol & Radiol Sci, Bethesda, MD 20814 USA. RP Bui-Mansfield, LT (reprint author), Brooke Army Med Ctr, JBSA, Dept Radiol, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM liem.t.mansfield.ctr@mail.mil NR 44 TC 7 Z9 7 U1 0 U2 6 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X EI 1546-3141 J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD JUN PY 2014 VL 202 IS 6 BP 1281 EP 1290 DI 10.2214/AJR.13.11564 PG 10 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA AI6DB UT WOS:000336959000036 PM 24848826 ER PT J AU Sviatenko, LK Gorb, L Hill, FC Leszczynska, D Leszczynski, J AF Sviatenko, L. K. Gorb, L. Hill, F. C. Leszczynska, D. Leszczynski, J. TI Theoretical Study of One-Electron Reduction And Oxidation Potentials of N-Heterocyclic Compounds SO CHEMISTRY OF HETEROCYCLIC COMPOUNDS LA English DT Article DE N-heterocyclic compounds; DFT calculations; electrochemistry; redox potential; solvation ID POLARIZABLE CONTINUUM MODEL; DENSITY-FUNCTIONAL THEORY; NONCOVALENT INTERACTIONS; THERMOCHEMICAL KINETICS; HETEROAROMATIC BASES; HYDROCARBONS; IONIZATION; SOLVATION; PRODUCTS; SOLUTES AB Computational protocols that successfully predict standard reduction potentials of N-heterocyclic compounds in dimethyl formamide and their standard oxidation potentials in acetonitrile were developed. Different solvation models were verified in conjunction with the MPWB1K/6-31 + G(d) level of density functional theory. For reduction potentials calculations, the PCM(UA0) and SMD(Bondi) models were used to compute solvation energies of neutral forms and anion-radical forms, respectively. For oxidation potential calculations, the best results were obtained by a combination of SMD(UAHF) and PCM(Bondi) models to compute solvation energies of neutral forms and cation-radical forms, respectively. The mean absolute deviations (MAD) and root mean square errors (RMSE) of the current theoretical models for reduction potentials were found to be 0.09 V and 0.10, respectively, and for oxidation potentials MAD = 0.12 V and RMSE = 0.16. C1 [Sviatenko, L. K.; Leszczynski, J.] Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Nanotox Ctr, Jackson, MS 39217 USA. [Sviatenko, L. K.] Kirovohrad Volodymyr Vynnychenko State Pedag Univ, UA-25006 Kirovohrad, Ukraine. [Gorb, L.] Badger Tech Serv Inc, Huntsville, AL 35805 USA. [Hill, F. C.] US Army ERDC, Vicksburg, MS 39180 USA. [Leszczynska, D.] Jackson State Univ, Dept Civil & Environm Engn, Interdisciplinary Nanotox Ctr, Jackson, MS 39217 USA. RP Leszczynski, J (reprint author), Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Nanotox Ctr, 1400 John R Lynch St, Jackson, MS 39217 USA. EM lsv@icnanotox.org; lgorb@icnanotox.org; frances.c.hill@usace.army.mil; jerzy@icnanotox.org FU ERDC [W912HZ-13-P-0037]; National Science Foundation [OCI-1053575]; XSEDE [DMR110088] FX We thank ERDC for financial support (grant number W912HZ-13-P-0037). The computation time was provided by the Extreme Science and Engineering Discovery Environment (XSEDE) by National Science Foundation Grant Number OCI-1053575 and XSEDE award allocation Number DMR110088 and by the Mississippi Center for Supercomputer Research. NR 28 TC 2 Z9 2 U1 1 U2 12 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0009-3122 EI 1573-8353 J9 CHEM HETEROCYCL COM+ JI Chem. Heterocycl. Compds. PD JUN PY 2014 VL 50 IS 3 BP 311 EP 318 DI 10.1007/s10593-014-1484-5 PG 8 WC Chemistry, Organic SC Chemistry GA AI8DZ UT WOS:000337138400002 ER PT J AU Ramon, ES Tyo, JS Ziolkowski, RW Skipper, MC Abdalla, MD Martin, JM Altgilbers, LL AF Ramon, Eric S. Tyo, J. Scott Ziolkowski, Richard W. Skipper, Michael C. Abdalla, Michael D. Martin, Joshua M. Altgilbers, Larry L. TI A Compact Multi-Frequency, High Power Radiating System Combining Dual-Band, Electrically Small Magnetic EZ Antennas and Multi-Frequency Standing Wave Oscillator Sources SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Article DE Electrically small antennas; high power microwave generation; mesoband sources; multifrequency antennas AB High power microwave (HPM) sources are typically bulky and massive in order to be able to radiate the extremely high source powers with a good impedance match and low losses. For this reason, it is sometimes difficult to incorporate an HPM antenna onto a desired platform when the available space is small. In previous work, we have adapted an electrically small EZ antenna to operate with a mesoband, quarter-wave oscillator source. The EZ antenna operates over a ground plane, but is conformal and low profile in that the electrical size is on the order of lambda/12, making it attractive for applications where there is sufficient internal space to place a full source, but only limited space outside the platform for the radiating subsystem. Here we extend the capabilities of the oscillator/EZ antenna combination by introducing a dual band design for the antenna and altering the oscillator to produce multiple resonant frequencies. Designs are shown here that operate in the UHF (500-800 MHz) and L-band (1.5-1.8 GHz), but the operation frequencies are essentially arbitrary. This paper shows modeling results that predict high antenna efficiency with electrical sizes of ka < 1 at f = 500 MHz. C1 [Ramon, Eric S.; Tyo, J. Scott; Ziolkowski, Richard W.] Univ Arizona, Coll Opt Sci, Tucson, AZ 85721 USA. [Ramon, Eric S.; Tyo, J. Scott; Ziolkowski, Richard W.] Univ Arizona, ECE Dept, Tucson, AZ 85721 USA. [Skipper, Michael C.; Abdalla, Michael D.] ASR Corp, Albuquerque, NM 87114 USA. [Martin, Joshua M.; Altgilbers, Larry L.] US Army Space & Missile Def Command, Huntsville, AL 35805 USA. Missile Def Command, Huntsville, AL 35805 USA. RP Ramon, ES (reprint author), Univ Arizona, Coll Opt Sci, Tucson, AZ 85721 USA. FU Phase 2 SBIR award from the US Army FX This work was supported by a Phase 2 SBIR award from the US Army, and was cleared for public release by the Public Affairs Office at the Space & Missile Defense Command, Huntsville, AL, USA. NR 17 TC 1 Z9 1 U1 0 U2 13 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-926X EI 1558-2221 J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD JUN PY 2014 VL 62 IS 6 BP 3281 EP 3289 DI 10.1109/TAP.2014.2313135 PG 9 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA AI7ZS UT WOS:000337122100040 ER PT J AU Srisurapanon, S Sukwit, S Chuenchitra, T Rojanasang, P Wongjitrat, C AF Srisurapanon, Surangrat Sukwit, Suchitra Chuenchitra, Thippawan Rojanasang, Pornparn Wongjitrat, Chatchawan TI THE DIFFERENCE BETWEEN THE NUMBERS OF LYMPHOCYTE EXPRESSING CO-STIMULATORY MOLECULES FROM HBV AND HIV-INFECTED INDIVIDUALS SO INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY LA English DT Meeting Abstract C1 [Srisurapanon, Surangrat; Rojanasang, Pornparn] Srinakharinwirot Univ, Fac Med, Dept Pathol, Bangkok, Thailand. [Sukwit, Suchitra; Chuenchitra, Thippawan] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Wongjitrat, Chatchawan] Srinakharinwirot Univ, Fac Med, Dept Internal Med, Bangkok, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1751-5521 EI 1751-553X J9 INT J LAB HEMATOL JI Int. J. Lab. Hematol. PD JUN PY 2014 VL 36 SU 1 SI SI BP 101 EP 102 PG 2 WC Hematology SC Hematology GA AI9HS UT WOS:000337244300235 ER PT J AU Thompson, M Sidow, SJ Lindsey, K Chuang, A McPherson, JC AF Thompson, Matthew Sidow, Stephanie J. Lindsey, Kimberly Chuang, Augustine McPherson, James C., III TI Evaluation of a New Filing System's Ability to Maintain Canal Morphology SO JOURNAL OF ENDODONTICS LA English DT Article DE Hyflex CM; instrumentation; ProFile; transportation ID SIMULATED ROOT CANALS; CENTERING ABILITY; INSTRUMENTATION TECHNIQUES; ROTARY INSTRUMENTS; BENDING PROPERTIES; SHAPING ABILITY; NICKEL; PROFILE; MEMORY; FILES AB Introduction: The manufacturer of the Hyflex CM endodontic files claims the files remain centered within the canal, and if unwound during treatment, they will regain their original shape after sterilization. The purpose of this study was to evaluate and compare the canal centering ability of the Hyflex CM and the ProFile ISO filing systems after repeated uses in simulated canals, followed by autoclaving. Methods: Sixty acrylic blocks with a canal curvature of 45 degrees were stained with methylene blue, photographed, and divided into 2 groups, H (Hyflex CM) and P (ProFile ISO). The groups were further subdivided into 3 subgroups: H1, H2, H3; P1, P2, P3 (n = 10). Groups H1 and P1 were instrumented to 40 (.04) with the respective file system. Used files were autoclaved for 26 minutes at 126 degrees C. After sterilization, the files were used to instrument groups H2 and P2. The same sterilization and instrumentation procedure was repeated for groups H3 and P3. Post-instrumentation digital images were taken and super-imposed over the pre-instrumentation images. Changes in the location of the center of the canal at predetermined reference points were recorded and compared within subgroups and between filing systems. Results: Statistical differences in intergroup and intragroup transportation measures were analyzed by using the Kruskal-Wallis analysis of variance of ranks with the Bonferroni post hoc test. There was a difference between Hyflex CM and ProFile ISO groups, although it was not statistically significant. Intragroup differences for both Hyflex CM and ProFile ISO groups were not significant (P < .05). Conclusions: The Hyflex CM and Profile ISO files equally maintained the original canal's morphology after 2 sterilization cycles. C1 [Thompson, Matthew; Sidow, Stephanie J.; Lindsey, Kimberly] US Army Dent Act, Ft Gordon, GA 30905 USA. [Chuang, Augustine; McPherson, James C., III] Dept Clin Invest, Augusta, GA USA. RP Lindsey, K (reprint author), US Army Dent Act, Dept Endodont, Ft Gordon, GA 30905 USA. EM kimberly.w.lindsey.mil@mail.mil NR 21 TC 1 Z9 3 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0099-2399 EI 1878-3554 J9 J ENDODONT JI J. Endod. PD JUN PY 2014 VL 40 IS 6 BP 867 EP 870 DI 10.1016/j.joen.2013.10.016 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA AI8SW UT WOS:000337198300019 PM 24862719 ER PT J AU Wilmoth, MC Shapiro, SE AF Wilmoth, Margaret C. Shapiro, Susan E. TI The Intentional Development of Nurses as Leaders A Proposed Framework SO JOURNAL OF NURSING ADMINISTRATION LA English DT Article ID HEALTH; CARE AB In their 2010 report on The Future of Nursing, the Institute of Medicine called for nurses to be prepared to lead in all areas of healthcare. However, the nursing profession lacks consensus on a framework to guide the development of nurses as leaders and has yet to define essential leader competencies. This article reviews the Army's intentional, sequential, and progressive leader development program that is grounded in essential leader competencies. The applicability of this model to nursing is discussed, and examples of how it could be applied are highlighted. This article proposes the use of the military framework as a successful model for the intentional development of nurses as leaders to meet the triple aims of better care for patients, better health for populations, and reduced costs of care through more efficient use of resources. C1 [Wilmoth, Margaret C.] Georgia State Univ, Byrdine F Lewis Sch Nursing & Hlth Profess, Atlanta, GA 30303 USA. [Wilmoth, Margaret C.] US Army Reserve, Ft Bragg, NC USA. [Shapiro, Susan E.] Emory Healthcare, Nursing Res & Evidence Based Practice, Atlanta, GA USA. [Shapiro, Susan E.] Emory Univ, Nell Hodgson Woodruff Sch Nursing, Atlanta, GA 30322 USA. RP Wilmoth, MC (reprint author), POB 3995, Atlanta, GA 30302 USA. EM mwilmoth@gsu.edu NR 26 TC 2 Z9 2 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0002-0443 EI 1539-0721 J9 J NURS ADMIN JI J. Nurs. Adm. PD JUN PY 2014 VL 44 IS 6 BP 333 EP 338 DI 10.1097/NNA.0000000000000078 PG 6 WC Nursing SC Nursing GA AI8FJ UT WOS:000337144200007 PM 24853795 ER PT J AU Mehra, R Raghuvanshi, N Chandak, A Albert, DG Wilson, DK Manocha, D AF Mehra, Ravish Raghuvanshi, Nikunj Chandak, Anish Albert, Donald G. Wilson, D. Keith Manocha, Dinesh TI Acoustic pulse propagation in an urban environment using a three-dimensional numerical simulation SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID SOUND-PROPAGATION; NOISE-PROPAGATION; STREET CANYONS; CITY CANYONS; AREAS; DIFFRACTION; BUILDINGS; EFFICIENT; BARRIERS; IMPULSE AB Acoustic pulse propagation in outdoor urban environments is a physically complex phenomenon due to the predominance of reflection, diffraction, and scattering. This is especially true in non-line-of-sight cases, where edge diffraction and high-order scattering are major components of acoustic energy transport. Past work by Albert and Liu [J. Acoust. Soc. Am. 127, 1335-1346 (2010)] has shown that many of these effects can be captured using a two-dimensional finite-difference time-domain method, which was compared to the measured data recorded in an army training village. In this paper, a full three-dimensional analysis of acoustic pulse propagation is presented. This analysis is enabled by the adaptive rectangular decomposition method by Raghuvanshi, Narain and Lin [IEEE Trans. Visual. Comput. Graphics 15, 789-801 (2009)], which models sound propagation in the same scene in three dimensions. The simulation is run at a much higher usable bandwidth (nearly 450Hz) and took only a few minutes on a desktop computer. It is shown that a three-dimensional solution provides better agreement with measured data than two-dimensional modeling, especially in cases where propagation over rooftops is important. In general, the predicted acoustic responses match well with measured results for the source/sensor locations. C1 [Mehra, Ravish; Chandak, Anish; Manocha, Dinesh] Univ N Carolina, Dept Comp Sci, Chapel Hill, NC 27599 USA. [Raghuvanshi, Nikunj] Microsoft Res, Redmond, WA 98052 USA. [Albert, Donald G.; Wilson, D. Keith] US Army Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Mehra, R (reprint author), Univ N Carolina, Dept Comp Sci, Chapel Hill, NC 27599 USA. EM ravish.mehra07@gmail.com RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 FU Link Foundation Fellowship in Advanced Simulation and Training; ARO [W911NF-10-1-0506, W911NF-12-1-0430, W911NF-13-C-0037]; National Science Foundation (NSF) [0917040, 1320644]; U.S. Army Engineer Research and Development Center's Geospatial Research and Engineering business area FX This research was supported in part by the Link Foundation Fellowship in Advanced Simulation and Training, ARO Contracts W911NF-10-1-0506, W911NF-12-1-0430, W911NF-13-C-0037, and the National Science Foundation (NSF awards 0917040, 1320644). Additional funding for this research was provided by the U.S. Army Engineer Research and Development Center's Geospatial Research and Engineering business area. NR 43 TC 3 Z9 3 U1 1 U2 6 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 EI 1520-8524 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD JUN PY 2014 VL 135 IS 6 BP 3231 EP 3242 DI 10.1121/1.4874495 PG 12 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA AI7VX UT WOS:000337110200028 PM 24907788 ER PT J AU Reine, KJ Clarke, D Dickerson, C AF Reine, Kevin J. Clarke, Douglas Dickerson, Charles TI Characterization of underwater sounds produced by hydraulic and mechanical dredging operations SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID SHIP NOISE; FISH; ABUNDANCE; SEA AB Sound recordings were made of two dredging operations at hydrophone depths of 3 and 9.1m at distances up to 1.2 km from the source in shallow waters (< 15 m) of New York Harbor. Sound sources included rock fracturing by a hydraulic cutterhead dredge and six distinct sources associated with a mechanical backhoe dredging operation during rock excavation. To place sound emitted from these dredges in perspective with other anthropogenic sounds, recordings were also made of several deep-draft commercial vessels. Results are presented as sound pressure levels (SPLs) in one-third octave versus range across the 20 Hz to 20 kHz frequency band. To address concerns for protection of fishery resource occupying the harbor, SPL were examined at frequency bands of 50-1000 Hz and 100-400 Hz, the ranges where the majority of fishes without hearing specializations detect sound and the range of greatest sensitivity, respectively. Source levels (dB re 1 mu Pa-1m rms) were back calculated using fitted regression (15LogR). The strongest sound sources (180-188.9 dB) were emitted by commercial shipping. Rock fracturing produced a source level of 175 dB, whereas six distinct sources associated with rock excavation had source levels ranging from 164.2 to 179.4 dB re 1 mu Pa-1m (rms). C1 [Reine, Kevin J.; Clarke, Douglas] US Army Engineer Res & Dev Ctr, Environm Lab, Wetlands & Coastal Ecol Branch, Vicksburg, MS 39180 USA. [Dickerson, Charles] Bowhead Sci & Technol Serv, Vicksburg, MS 39180 USA. RP Reine, KJ (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, Wetlands & Coastal Ecol Branch, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Kevin.J.Reine@usace.army.mil FU USACE New York District; U.S. Army Engineer Research and Development Center, Vicksburg, MI - Dredging Operations and Environmental Research (DOER) Program FX This study is a joint effort sponsored by the USACE New York District and the U.S. Army Engineer Research and Development Center, Vicksburg, MI, supported by the Dredging Operations and Environmental Research (DOER) Program. The authors wish to express thanks to Kate Alcoba and Ann Marie Dilorenzo of the Estuaries Section, Planning Division, New York District; Timothy Lafontaine, Chief of Caven Point Operations, New York District; and Captain Mike Marcello and First Mate Ray Ryan, crew of the M/V Hudson, for providing logistical and technical support for field data collection efforts. NR 44 TC 4 Z9 4 U1 0 U2 24 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 EI 1520-8524 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD JUN PY 2014 VL 135 IS 6 BP 3280 EP 3294 DI 10.1121/1.4875712 PG 15 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA AI7VX UT WOS:000337110200032 PM 24907792 ER PT J AU Aboudara, M Mahoney, PF Hicks, B Cuadrado, D AF Aboudara, Matthew Mahoney, P. F. Hicks, B. Cuadrado, D. TI Primary blast lung injury at a NATO Role 3 hospital SO JOURNAL OF THE ROYAL ARMY MEDICAL CORPS LA English DT Article DE Respiratory Medicine (see Thoracic Medicine) ID MANAGEMENT; EPIDEMIOLOGY AB Background Primary blast lung injury (PBLI) is defined as lung contusion from barotrauma following an explosive mechanism of injury (MOI). Military data have focused on PBLI characteristics following evacuation from the combat theatre; less is known about its immediate management and epidemiology in the deployed setting. We conducted a quality improvement project to describe the prevalence, clinical characteristics, management strategies and evacuation techniques for PBLI patients prior to evacuation. Methods Patients admitted to a Role 3 hospital in southwest, Afghanistan, from January 2008 to March 2013 with a blast MOI were identified through the Department of Defense Trauma Registry; International Classification of Diseases 9 codes and patient record review were used to identify the PBLI cohort from radiology reports. Descriptive statistics and Fishers exact test were used to report findings. Results Prevalence of PBLI among blast injured patients with radiology reports was 11.2% (73/648). The population exhibited high Injury Severity Scores median 25 (IQR 14-34) and most received a massive blood transfusion (mean 33.438.3 total blood products/24h). The mean positive end expiratory pressure (PEEP) requirement was 6.2 +/- 3.7 (range 5-15)cm H2O and PaO2 to FiO(2) ratio was 297 +/- 175.2 (66-796)mmHg. However, 16.6% of patients had a PaO2 to FiO(2) ratio <200, 13.3% required PEEP 10cm H2O and one patient required specialised evacuation for respiratory failure. A dismounted MOI (72.8%) and evacuation from point of injury by the Medical Emergency Response Team (62.3%) appeared to be associated with worse lung injury. Only eight of the 73 PBLI patients died and of the five with retrievable records, none died from respiratory failure. Conclusions PBLI has a low prevalence and conventional lung protective ventilator management is generally appropriate immediately after injury; application of advanced modes of ventilation and specialised evacuation assistance may be required. PBLI may be a marker of underlying injury severity since all deaths were not due to respiratory failure. Further work is needed to determine exact MOI in mounted and dismounted casualties. C1 [Aboudara, Matthew] Tripler Army Med Ctr, Dept Med, Honolulu, HI 96859 USA. [Mahoney, P. F.] Royal Ctr Def Med, Dept Mil Anaesthesia & Crit Care, Birmingham, W Midlands, England. [Hicks, B.] William Beaumont Army Med Ctr, Dept Radiol, El Paso, TX 79920 USA. [Cuadrado, D.] Vanderbilt Univ, Med Ctr, Vanderbilt Heart Inst, Nashville, TN USA. RP Aboudara, M (reprint author), Tripler Army Med Ctr, Dept Med, Honolulu, HI 96859 USA. EM maboudara23@gmail.com NR 12 TC 5 Z9 6 U1 0 U2 5 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0035-8665 EI 2052-0468 J9 J ROY ARMY MED CORPS JI J. R. Army Med. Corps PD JUN PY 2014 VL 160 IS 2 BP 161 EP 166 DI 10.1136/jramc-2013-000216 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA AI9YA UT WOS:000337302200017 PM 24464466 ER PT J AU Brown, KV Penn-Barwell, JG Rand, BC Wenke, JC AF Brown, Kate V. Penn-Barwell, J. G. Rand, B. C. Wenke, J. C. TI Translational research to improve the treatment of severe extremity injuries SO JOURNAL OF THE ROYAL ARMY MEDICAL CORPS LA English DT Article DE Trauma Management ID BONE MORPHOGENETIC PROTEIN-2; OPEN TIBIAL FRACTURES; SEGMENTAL DEFECT; INFECTIOUS COMPLICATIONS; POLYURETHANE SCAFFOLDS; REDUCE INFECTION; RAT FEMUR; MODEL; DELIVERY; WOUNDS AB Objectives Severe extremity injuries are the most significant injury sustained in combat wounds. Despite optimal clinical management, non-union and infection remain common complications. In a concerted effort to dovetail research efforts, there has been a collaboration between the UK and USA, with British military surgeons conducting translational studies under the auspices of the US Institute of Surgical Research. This paper describes 3years of work. Methods A variety of studies were conducted using, and developing, a previously validated rat femur critical-sized defect model. Timing of surgical debridement and irrigation, different types of irrigants and different means of delivery of antibiotic and growth factors for infection control and to promote bone healing were investigated. Results Early debridement and irrigation were independently shown to reduce infection. Normal saline was the most optimal irrigant, superior to disinfectant solutions. A biodegradable gel demonstrated superior antibiotic delivery capabilities than standard polymethylmethacrylate beads. A polyurethane scaffold was shown to have the ability to deliver both antibiotics and growth factors. Discussion The importance of early transit times to Role 3 capabilities for definitive surgical care has been underlined. Novel and superior methods of antibiotic and growth factor delivery, compared with current clinical standards of care, have been shown. There is the potential for translation to clinical studies to promote infection control and bone healing in these devastating injuries. C1 [Brown, Kate V.; Penn-Barwell, J. G.; Rand, B. C.; Wenke, J. C.] US Army Inst Surg Res, San Antonio, TX USA. [Brown, Kate V.; Penn-Barwell, J. G.; Rand, B. C.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. RP Brown, KV (reprint author), Royal Army Med Corps, Birmingham B15 2TH, W Midlands, England. EM katevbrown@aol.com OI rand, ben/0000-0002-9938-2082 NR 31 TC 1 Z9 1 U1 0 U2 3 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0035-8665 EI 2052-0468 J9 J ROY ARMY MED CORPS JI J. R. Army Med. Corps PD JUN PY 2014 VL 160 IS 2 BP 167 EP 170 DI 10.1136/jramc-2013-000235 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA AI9YA UT WOS:000337302200018 PM 24464465 ER PT J AU Gillespie, DL Cherry, KJ Evans, T Corpus, R Rasmussen, T AF Gillespie, David L. Cherry, Kenneth J. Evans, Thomas Corpus, Raul Rasmussen, Todd TI Civilian/Military Collaboration in the Management of Military Vascular Trauma: A 10-year Report of the SVS Volunteer Program SO JOURNAL OF VASCULAR SURGERY LA English DT Meeting Abstract CT Vascular Annual Meeting of the Society-for-Vascular-Surgery CY JUN 05-07, 2014 CL Boston, MA SP Soc Vasc Surg C1 [Gillespie, David L.] Southcoast Hlth Syst, Cardiovasc Care Ctr, Fall River, MA USA. [Cherry, Kenneth J.] Univ Virginia, Charlottesville, VA USA. [Corpus, Raul] US Army Inst Surg Res, San Antonio, TX USA. [Evans, Thomas] Wilford Hall USAF Med Ctr, San Antonio, TX 78236 USA. [Rasmussen, Todd] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD JUN PY 2014 VL 59 IS 6 SU S BP 35S EP 36S PG 2 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA AI9ND UT WOS:000337258400071 ER PT J AU Perkins, ZB Yet, B Glasgow, S Marsh, W Brohi, K Rasmussen, TE Tai, NR AF Perkins, Zane B. Yet, Barbaros Glasgow, Simon Marsh, William Brohi, Karim Rasmussen, Todd E. Tai, Nigel R. TI Prognostic Factors for Amputation Following Surgical Repair of Lower Extremity Vascular Trauma: A Systematic Review and Meta-Analysis of Observational Studies SO JOURNAL OF VASCULAR SURGERY LA English DT Meeting Abstract CT Vascular Annual Meeting of the Society-for-Vascular-Surgery CY JUN 05-07, 2014 CL Boston, MA SP Soc Vasc Surg C1 [Perkins, Zane B.; Glasgow, Simon; Brohi, Karim] Univ London, Ctr Trauma Sci, London, England. [Tai, Nigel R.] Royal Ctr Def Med, Birmingham, W Midlands, England. [Rasmussen, Todd E.] US Army Inst Surg Res, San Antonio, TX USA. [Yet, Barbaros; Marsh, William] Univ London, London, England. RI Marsh, David/A-3213-2016 OI Marsh, David/0000-0003-0212-6363 NR 0 TC 0 Z9 0 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD JUN PY 2014 VL 59 IS 6 SU S BP 75S EP 75S PG 1 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA AI9ND UT WOS:000337258400154 ER PT J AU Heafner, TA Lewis, C Abercrombie, J Propper, B Ching, YM Arthurs, ZM AF Heafner, Thomas A. Lewis, Clayton Abercrombie, Jonathan Propper, Brandon Ching, Yiming Arthurs, Zachary M. TI Quantitative In Vitro Model for the Study of Bacterial Attachment on Vascular Conduits SO JOURNAL OF VASCULAR SURGERY LA English DT Meeting Abstract CT Vascular Annual Meeting of the Society-for-Vascular-Surgery CY JUN 05-07, 2014 CL Boston, MA SP Soc Vasc Surg C1 [Heafner, Thomas A.; Lewis, Clayton; Propper, Brandon; Ching, Yiming; Arthurs, Zachary M.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. [Abercrombie, Jonathan] US Army Inst Surg Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD JUN PY 2014 VL 59 IS 6 SU S BP 85S EP 86S PG 2 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA AI9ND UT WOS:000337258400178 ER PT J AU Yu, LL Lee, YH Ling, X Santos, EJG Shin, YC Lin, YX Dubey, M Kaxiras, E Kong, J Wang, H Palacios, T AF Yu, Lili Lee, Yi-Hsien Ling, Xi Santos, Elton J. G. Shin, Yong Cheol Lin, Yuxuan Dubey, Madan Kaxiras, Efthimios Kong, Jing Wang, Han Palacios, Tomas TI Graphene/MoS2 Hybrid Technology for Large-Scale Two-Dimensional Electronics SO NANO LETTERS LA English DT Article DE Molybdenum disulfide; graphene; heterostructure; field-effect transistor; integrated circuits; flexible and transparent ID CHEMICAL-VAPOR-DEPOSITION; THIN-FILM TRANSISTORS; MOS2 TRANSISTORS; LARGE-AREA; HIGH-PERFORMANCE; HIGH-QUALITY; HETEROSTRUCTURES; DIELECTRICS AB Two-dimensional (2D) materials have generated great interest in the past few years as a new toolbox for electronics. This family of materials includes, among others, metallic graphene, semiconducting transition metal dichalcogenides (such as MoS2), and insulating boron nitride. These materials and their heterostructures offer excellent mechanical flexibility, optical transparency, and favorable transport properties for realizing electronic, sensing, and optical systems on arbitrary surfaces. In this paper, we demonstrate a novel technology for constructing large-scale electronic systems based on graphene/molybdenum disulfide (MoS2) heterostructures grown by chemical vapor deposition. We have fabricated high-performance devices and circuits based on this heterostructure, where MoS2 is used as the transistor channel and graphene as contact electrodes and circuit interconnects. We provide a systematic comparison of the graphene/MoS2 heterojunction contact to more traditional MoS2-metal junctions, as well as a theoretical investigation, using density functional theory, of the origin of the Schottky barrier height. The tunability of the graphene work function with electrostatic doping significantly improves the ohmic contact to MoS2. These high-performance large-scale devices and circuits based on this 2D heterostructure pave the way for practical flexible transparent electronics. C1 [Yu, Lili; Ling, Xi; Lin, Yuxuan; Kong, Jing; Wang, Han; Palacios, Tomas] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA. [Lee, Yi-Hsien] Natl Tsing Hua Univ, Hsinchu 30013, Taiwan. [Santos, Elton J. G.; Kaxiras, Efthimios] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA. [Shin, Yong Cheol] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA. [Dubey, Madan] US Army, Res Lab, Adelphi, MD 20783 USA. [Kaxiras, Efthimios] Harvard Univ, Dept Phys, Cambridge, MA 02138 USA. RP Yu, LL (reprint author), MIT, Dept Elect Engn & Comp Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA. EM liliyu@mit.edu; hw254@mit.edu; tpalacios@mit.edu FU NSF [TG-DMR120049, TG-PHY120021] FX The authors would like to thank Allen Hsu and Xu Zhang for their helpful advice on device fabrication and measurement. The authors acknowledge financial support from the Office of Naval Research (ONR) PECASE Program, the ONR GATE MUM program, the Army Research Laboratory, and Center for Integrated Quantum Materials (CIQM). This research has made use of the MIT's Microsystem Technology Laboratory cleanrooms. We acknowledge the use of computational resources provided by the Extreme Science and Engineering Discovery Environment (XSEDE), supported by NSF Grants TG-DMR120049 and TG-PHY120021. NR 54 TC 128 Z9 128 U1 56 U2 475 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1530-6984 EI 1530-6992 J9 NANO LETT JI Nano Lett. PD JUN PY 2014 VL 14 IS 6 BP 3055 EP 3063 DI 10.1021/nl404795z PG 9 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA AJ0JP UT WOS:000337337100014 PM 24810658 ER PT J AU Rokni, MR Widener, CA Ahrenkiel, SP Jasthi, BK Champagne, VR AF Rokni, M. R. Widener, C. A. Ahrenkiel, S. P. Jasthi, B. K. Champagne, V. R. TI Annealing behaviour of 6061 aluminium deposited by high pressure cold spray SO SURFACE ENGINEERING LA English DT Article DE Aluminium; Cold spraying; Segregation; Annealing; TEM ID VACANCY FORMATION ENERGIES; REDUCING GRAIN-BOUNDARY; AL-MG ALLOYS; SOLUTE SEGREGATION; MECHANICAL-PROPERTIES; DISLOCATION LINE; DIFFUSION; COATINGS; MICROSTRUCTURE; DIFFRACTION AB Aluminium 6061 deposited by high pressure cold spray was analysed using a transmission electron microscope (TEM) to characterise its microstructure and response to annealing to 450 degrees C in the plane of the deposition and perpendicular to the deposited layers. The cold sprayed deposition was also analysed with scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS) analysis and differential scanning calorimeter (DSC). Segregation of the solute atoms (Mg and Si) at the grain boundaries during cold spraying was seen to play a crucial role in stabilising the deformation substructure until specific temperatures, and was found to have a significant effect on the annealing behaviour of the microstructure in the two different directions. C1 [Rokni, M. R.; Widener, C. A.; Jasthi, B. K.] South Dakota Sch Mines & Technol SDSM&T, Dept Mat & Met Engn, Adv Mat Proc Ctr, Rapid City, SD 57701 USA. [Ahrenkiel, S. P.] South Dakota Sch Mines & Technol SDSM&T, Dept Nanosci & Nanoengn, Rapid City, SD USA. [Champagne, V. R.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen, MD USA. RP Rokni, MR (reprint author), South Dakota Sch Mines & Technol SDSM&T, Dept Mat & Met Engn, Adv Mat Proc Ctr, Rapid City, SD 57701 USA. EM mohammadreza.rokni@mines.sdsmt.edu RI Jasthi, Bharat/D-4312-2009 FU Pueblo Economic Development Corporation under Army Research Lab [W911NF-11-2-0014] FX This work was performed under subcontract to the Pueblo Economic Development Corporation under Army Research Lab contract no. W911NF-11-2-0014. NR 44 TC 5 Z9 5 U1 1 U2 16 PU MANEY PUBLISHING PI LEEDS PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND SN 0267-0844 EI 1743-2944 J9 SURF ENG JI Surf. Eng. PD JUN PY 2014 VL 30 IS 5 BP 361 EP 368 DI 10.1179/1743294413Y.0000000209 PN 1 PG 8 WC Materials Science, Coatings & Films SC Materials Science GA AI8DT UT WOS:000337137400010 ER PT J AU Rini, EA Weintrob, AC Tribble, DR Lloyd, BA Warkentien, TE Shaikh, F Li, P Aggarwal, D Carson, ML Murray, CK AF Rini, Elizabeth A. Weintrob, Amy C. Tribble, David R. Lloyd, Bradley A. Warkentien, Tyler E. Shaikh, Faraz Li, Ping Aggarwal, Deepak Carson, M. Leigh Murray, Clinton K. CA Infect Dis Clinical Res Program TI Short Report: Compliance with Antimalarial Chemoprophylaxis Recommendations for Wounded United States Military Personnel Admitted to a Military Treatment Facility SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID AFGHANISTAN; MALARIA; PREVALENCE; MEFLOQUINE; OUTBREAK AB Malaria chemoprophylaxis is used as a preventive measure in military personnel deployed to malaria-endemic countries. However, limited information is available on compliance with chemoprophylaxis among trauma patients during hospitalization and after discharge. Therefore, we assessed antimalarial primary chemoprophylaxis and presumptive antirelapse therapy (primaquine) compliance among wounded United States military personnel after medical evacuation from Afghanistan (June 2009 August 2011) to Landstuhl Regional Medical Center in Landstuhl, Germany, and then to three U.S. military hospitals. Among admissions at Landstuhl Regional Medical Center, 74% of 2,540 patients were prescribed primary chemoprophylaxis and < 1% were prescribed primaquine. After transfer of 1,331 patients to U.S. hospitals, 93% received primary chemoprophylaxis and 33% received primaquine. Of 751 trauma patients with available post-admission data, 42% received primary chemoprophylaxis for four weeks, 33% received primaquine for 14 days, and 17% received both. These antimalarial chemoprophylaxis prescription rates suggest that improved protocols to continue malaria chemoprophylaxis in accordance with force protection guidelines are needed. C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Weintrob, Amy C.; Warkentien, Tyler E.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. [Weintrob, Amy C.; Tribble, David R.; Shaikh, Faraz; Li, Ping; Aggarwal, Deepak; Carson, M. Leigh] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. Landstuhl Reg Med Ctr, Landstuhl, Germany. RP Rini, EA (reprint author), Landstuhl Reg Med Ctr, CMR 402,Box 1838, APO, AE 09180 USA. EM elizabeth.a.rini.mil@mail.mil; amy.c.weintrob.ctr@health.mil; david.tribble@usuhs.edu; bradley.lloyd@us.af.mil; tyler.e.warkentien@health.mil; fshaikh@idcrp.org; pli@idcrp.org; daggarwal@idcrp.org; lcarson@idcrp.org; clinton.k.murray.mil@mail.mil FU Infectious Disease Clinical Research Program, a Department of Defense program through the Uniformed Services University of the Health Sciences [IDCRP-024]; National Institute of Allergy and Infectious Diseases, National Institute of Health [Y1-AI-5072]; Department of the Navy FX The study (IDCRP-024) was supported by the Infectious Disease Clinical Research Program, a Department of Defense program executed through the Uniformed Services University of the Health Sciences; the National Institute of Allergy and Infectious Diseases, National Institute of Health, under Inter-Agency Agreement Y1-AI-5072; and the Department of the Navy under the Wounded, Ill, and Injured Program. NR 18 TC 2 Z9 2 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 2014 VL 90 IS 6 BP 1113 EP 1116 DI 10.4269/ajtmh.13-0646 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA AI4FD UT WOS:000336820200023 PM 24732457 ER PT J AU Grogl, M Sosa, N Kreishman-Deitrick, M AF Grogl, Max Sosa, Nestor Kreishman-Deitrick, Mara TI Topical Paromomycin and Gentamicin for New World Cutaneous Leishmaniasis in Panama Response SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Letter C1 [Grogl, Max] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Sosa, Nestor] Inst Conmemorat Gorgas Estudios Salud, Panama City, Panama. [Kreishman-Deitrick, Mara] USAMMDA, Ft Detrick, MD USA. RP Grogl, M (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. EM max.grogl@gmail.corn NR 8 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 2014 VL 90 IS 6 BP 1192 EP 1192 DI 10.4269/ajtmh.14-0040b PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA AI4FD UT WOS:000336820200039 PM 24898982 ER PT J AU Razmi, AM Barry, DA Lemmin, U Bonvin, F Kohn, T Bakhtyar, R AF Razmi, A. M. Barry, D. A. Lemmin, U. Bonvin, F. Kohn, T. Bakhtyar, R. TI Direct effects of dominant winds on residence and travel times in the wide and open lacustrine embayment: Vidy Bay (Lake Geneva, Switzerland) SO AQUATIC SCIENCES LA English DT Article DE Delft3D; Hydrodynamics; Particle tracking; Gyre; Dominant winds; Wastewater effluent ID PERSONAL CARE PRODUCTS; WATER; MODEL; PHARMACEUTICALS; CIRCULATION; RESERVOIRS; TRANSPORT; CURRENTS; RISK AB Numerical simulations were carried out to determine the residence (or flushing) time of water in Vidy Bay (north shore of Lake Geneva) for different meteorological conditions. A hydrodynamic model (Delft3D-FLOW) was applied to simulate the flow field in the embayment during 2010 and January 2011. Using these results, particle tracking was applied to estimate transport of wastewater effluent discharged into the embayment. The model predictions compared well with published field measurements of dissolved species (as given by electrical conductivity profiles) within the wastewater. The pelagic boundary of the embayment was defined by the largest within-bay gyre. Based on this definition, particle tracking was used to quantify the residence time under dominant wind conditions. Similarly, particle tracking was used to determine the travel time (i.e., time to exit the embayment) for each of Vidy Bay's three inflows (stream, stormwater and wastewater effluent). Although the wind field over the lake is variable, current patterns in the embayment can be simulated using the hydrodynamic model forced by a spatially uniform wind field. For a given wind speed, the main factor influencing residence and travel times is the wind angle. The presence of gyres leads to high mean residence times with large variability. As the wind direction becomes more aligned with the shoreline (i.e., with increasing westerly or easterly components), longshore currents dominate. These disrupt gyre formation and markedly reduce the mean and variability of embayment residence time. The numerical model was utilized to assess the potential for plume movement (in plan) from above the wastewater effluent outfall towards one of Lausanne's drinking water intakes. In the most direct pathway, westward longshore currents can move water from the embayment to the water column above the intake location. C1 [Razmi, A. M.; Barry, D. A.; Lemmin, U.; Bonvin, F.; Kohn, T.; Bakhtyar, R.] Ecole Polytech Fed Lausanne, Fac Environm Nat Architectural & Construit ENAC, Inst Ingn Environm, CH-1015 Lausanne, Switzerland. [Bakhtyar, R.] US Army Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Razmi, AM (reprint author), Ecole Polytech Fed Lausanne, Fac Environm Nat Architectural & Construit ENAC, Inst Ingn Environm, Stn 2, CH-1015 Lausanne, Switzerland. EM amir.razmi@epfl.ch; andrew.barry@epfl.ch; ulrich.lemmin@epfl.ch; florence.bonvin@epfl.ch; tamar.kohn@epfl.ch; roham.bakhtyar@unc.edu RI Barry, David/C-6077-2008; OI Barry, David/0000-0002-8621-0425; Kohn, Tamar/0000-0003-0395-6561 FU Fondation pour l'Etude des Eaux du Leman (FEEL); Swiss National Foundation [PDFMP2-123034/1] FX This publication is part of the international, interdisciplinary research project ELEMO (http://www.elemo.ch) to investigate the deep-waters of Lake Geneva using two Russian MIR submarines. Funding for this study was provided by the Fondation pour l'Etude des Eaux du Leman (FEEL) and the Swiss National Foundation (PDFMP2-123034/1). We thank Jean-Denis Bourquin for providing administrative support. The authors thank the three anonymous reviewers and the editor for their useful comments. NR 35 TC 5 Z9 6 U1 2 U2 29 PU SPRINGER BASEL AG PI BASEL PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND SN 1015-1621 EI 1420-9055 J9 AQUAT SCI JI Aquat. Sci. PD JUN PY 2014 VL 76 SU 1 BP S59 EP S71 DI 10.1007/s00027-013-0321-8 PG 13 WC Environmental Sciences; Limnology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA AI6HZ UT WOS:000336974600006 ER PT J AU Ellis, MW Schlett, CD Millar, EV Wilkins, KJ Crawford, KB Morrison-Rodriguez, SM Pacha, LA Gorwitz, RJ Lanier, JB Tribble, DR AF Ellis, Michael W. Schlett, Carey D. Millar, Eugene V. Wilkins, Kenneth J. Crawford, Katrina B. Morrison-Rodriguez, Stephanie M. Pacha, Laura A. Gorwitz, Rachel J. Lanier, Jeffrey B. Tribble, David R. TI Hygiene Strategies to Prevent Methicillin-Resistant Staphylococcus aureus Skin and Soft Tissue Infections: A Cluster-Randomized Controlled Trial Among High-Risk Military Trainees SO CLINICAL INFECTIOUS DISEASES LA English DT Article DE Staphylococcus aureus; methicillin-resistant Staphylococcus aureus (MRSA); skin and soft tissue infection; chlorhexidine; military ID HOUSEHOLD CONTACTS; MARINE RECRUITS; UNITED-STATES; COLONIZATION; EPIDEMIOLOGY; CELLULITIS; CHILDREN; PREVALENCE; CALIFORNIA; MUPIROCIN AB Background. Effective measures are needed to prevent methicillin-resistant Staphylococcus aureus (MRSA) skin and soft tissue infections (SSTIs) in high-risk community settings. The study objective was to evaluate the effect of personal hygiene-based strategies on rates of overall SSTI and MRSA SSTI. Methods. We conducted a prospective, field-based, cluster-randomized trial in US Army Infantry trainees from May 2010 through January 2012. There were 3 study groups with incrementally increased education and hygiene-based interventions: standard (S), enhanced standard (ES), and chlorhexidine (CHG). The primary endpoints were incidence of overall SSTI and MRSA SSTI. Results. The study included 30 209 trainees constituting 540 platoons (168 S, 192 ES, and 180 CHG). A total of 1203 (4%) participants developed SSTI, 316 (26%) due to MRSA. The overall SSTI rate was 4.15 (95% confidence interval [CI], 3.77-4.58) per 100 person-cycles. SSTI rates by study group were 3.48 (95% CI, 2.87-4.22) for S, 4.18 (95% CI, 3.56-4.90) for ES, and 4.71 (95% CI, 4.03-5.50) for CHG. The MRSA SSTI rate per 100 person-cycles for all groups was 1.10 (95% CI,.91-1.32). MRSA SSTI rates by study group were 1.0 (95% CI,.70-1.42) for S, 1.29 (95% CI,.98-1.71) for ES, and 0.97 (95% CI,.70-1.36) for CHG. Conclusions. Personal hygiene and education measures, including once-weekly use of chlorhexidine body wash, did not prevent overall SSTI or MRSA SSTI in a high-risk population of military trainees. C1 [Ellis, Michael W.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. [Schlett, Carey D.; Millar, Eugene V.; Crawford, Katrina B.; Morrison-Rodriguez, Stephanie M.; Tribble, David R.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Wilkins, Kenneth J.] NIDDK, NIH, Bethesda, MD 20892 USA. [Pacha, Laura A.] US Army Publ Hlth Command, Army Inst Publ Hlth, Aberdeen Proving Ground, MD USA. [Gorwitz, Rachel J.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Lanier, Jeffrey B.] Martin Army Community Hosp, Ft Benning, GA USA. RP Ellis, MW (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM michael.ellis@usuhs.edu FU Infectious Disease Clinical Research Program, a DoD program through the Uniformed Services University of the Health Sciences; National Institute of Allergy and Infectious Diseases, National Institutes of Health [Y1-AI-5072]; CDC, National Center for Emerging and Zoonotic Infectious Diseases, Division of Healthcare Quality Promotion [09FED914272]; DoD Global Emerging Infections Surveillance program [C0366-11-HS] FX The work was supported by the Infectious Disease Clinical Research Program, a DoD program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (Interagency Agreement Y1-AI-5072). Additional funding was provided by CDC, National Center for Emerging and Zoonotic Infectious Diseases, Division of Healthcare Quality Promotion (Interagency Agreement (09FED914272 to M. W. E.), and the DoD Global Emerging Infections Surveillance program (C0366-11-HS to M. W. E.). NR 38 TC 15 Z9 15 U1 0 U2 5 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JUN 1 PY 2014 VL 58 IS 11 BP 1540 EP 1548 DI 10.1093/cid/ciu166 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AI7AL UT WOS:000337031200009 PM 24633684 ER PT J AU Briggs, MJ Silver, AL Kopp, PJ AF Briggs, Michael J. Silver, Andrew L. Kopp, Paul J. TI PROBABILISTIC MODEL FOR PREDICTING SHIP UNDERKEEL CLEARANCE: FIELD AND LABORATORY VALIDATION SO COASTAL ENGINEERING JOURNAL LA English DT Article DE Deep-draft ships; deep-draft channel design; underkeel clearance; probabilistic channel design; wave-induced ship motions; GPS ship measurements; physical models; model validation AB This paper presents validation comparisons between field and laboratory measurements and a new probabilistic model for predicting ship underkeel clearance (UKC). Prototype ship motions and environmental data were obtained in May 1999 in the deep-draft entrance channel at Barbers Point, HI. These field measurements were reproduced in controlled laboratory studies in 2000 and 2002 with a model of the World Utility (WU) bulk carrier. These measurements constitute some of the data being used to validate the Corps's Channel Analysis and Design Evaluation Tool (CADET), a suite of programs to determine the optimum dredge depth for entrance channels. In general, the CADET predictions matched the field and laboratory measurements within cm-accuracy for wave heights that ranged from 45 cm to 75 cm. C1 [Briggs, Michael J.] Briggs Grp LLC, Vicksburg, MS 39180 USA. [Silver, Andrew L.; Kopp, Paul J.] Naval Surface Warfare Ctr, Carderock Div, Seakeeping Dept, West Bethesda, MD 20817 USA. [Briggs, Michael J.] US Army Engineer Res & Dev Ctr, Coastal & Hydraul Lab, CEERD HN HH, Vicksburg, MS 39180 USA. RP Briggs, MJ (reprint author), Briggs Grp LLC, Vicksburg, MS 39180 USA. EM briggsm1@cablelynx.com NR 22 TC 0 Z9 0 U1 0 U2 5 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE SN 0578-5634 EI 1793-6292 J9 COAST ENG J JI Coast Eng. J. PD JUN PY 2014 VL 56 IS 2 AR 1450010 DI 10.1142/S0578563414500107 PG 31 WC Engineering, Civil; Engineering, Ocean SC Engineering GA AI6GJ UT WOS:000336969800004 ER PT J AU Jin, X Pybus, BS Marcsisin, SR Logan, T Luong, TL Sousa, J Matlock, N Collazo, V Asher, C Carroll, D Olmeda, R Walker, LA Kozar, MP Melendez, V AF Jin, X. Pybus, B. S. Marcsisin, S. R. Logan, T. Luong, T. L. Sousa, J. Matlock, N. Collazo, V. Asher, C. Carroll, D. Olmeda, R. Walker, L. A. Kozar, M. P. Melendez, V. TI An LC-MS based study of the metabolic profile of primaquine, an 8-aminoquinoline antiparasitic drug, with an in vitro primary human hepatocyte culture model SO EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS LA English DT Article DE Metabolism; Transport; Pharmacogenomics ID RESISTANCE; CLEARANCE AB The 8-aminoquinoline drug primaquine (PQ) is currently the only drug in use against the persistent malaria caused by the hypnozoite-forming strains P. vivax and P. ovale. However, despite decades of research, its complete metabolic profile is still poorly understood. In the present study, the metabolism of PQ was evaluated by incubating the drug with pooled human hepatocytes cultured in vitro as well as with recombinant cytochrome P450 (CYP) isoenzymes, monoamine oxidases (MAO), and flavin-containing monooxygenases (FMO). Targeted LC-MS/MS analysis of hepatocyte incubations using chemical inhibitors indicated that PQ was predominantly metabolized by CYPs 3A4, 1A2 and 2D6, MAO-A, -B and FMO-3. Confirmation of these results was sought by incubation of PQ with the corresponding recombinant enzymes. Small amounts of carboxyprimaquine (CPQ), the major observed PQ metabolite in vivo, were detected in recombinant MAO-A incubations along with another peak at m/z 261, and no significant formation of CPQ with any other recombinant enzymes was observed. Incubations with all recombinant enzymes identified as potentially active towards PQ from the hepatocyte-based assay resulted in significant parent loss over the course of 1 h. These results suggest that several enzymes, including CYPs in combination with FMOs and MAOs, play a role in the overall metabolism of PQ and indicate a major role for MAO-A. Future studies to elucidate the potential role in cytotoxicity and/or efficacy of the PQ metabolite observed at m/z 261, as observed in MAO-A isoenzyme studies, are needed. C1 [Jin, X.; Pybus, B. S.; Marcsisin, S. R.; Logan, T.; Luong, T. L.; Sousa, J.; Matlock, N.; Collazo, V.; Asher, C.; Carroll, D.; Olmeda, R.; Kozar, M. P.; Melendez, V.] Walter Reed Army Inst Res, Dept Drug Dev, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Walker, L. A.] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA. RP Pybus, BS (reprint author), Walter Reed Army Inst Res, Dept Drug Dev, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM brandon.pybus@us.army.mil FU US Army Medical Research and Materiel Command (USAMRMC); Telemedicine and Advanced Technology Research Center (TATRC), at Fort Detrick, MD [W81-XWH-07-2-0095] FX This research and development project is supported by a grant to the University of Mississippi, and was awarded and administered by the US Army Medical Research and Materiel Command (USAMRMC) and the Telemedicine and Advanced Technology Research Center (TATRC), at Fort Detrick, MD, under award number: W81-XWH-07-2-0095. The views, opinions and/or findings contained in this presentation are those of the author(s) and do not necessarily reflect the views of the Department of Defense and should not be construed as an official DoD/Army position, policy or decision unless so designated by other documentation. No official endorsement should be made. NR 19 TC 8 Z9 8 U1 1 U2 14 PU SPRINGER FRANCE PI PARIS PA 22 RUE DE PALESTRO, PARIS, 75002, FRANCE SN 0378-7966 EI 2107-0180 J9 EUR J DRUG METAB PH JI Eur. J. Drug Metabol. Pharmacokinet. PD JUN PY 2014 VL 39 IS 2 BP 139 EP 146 DI 10.1007/s13318-013-0139-8 PG 8 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA AI7GG UT WOS:000337052600009 PM 23797843 ER PT J AU Inouye, KAS Bisch, FC Elsalanty, ME Zakhary, I Khashaba, RM Borke, JL AF Inouye, Kimberly Ann S. Bisch, Frederick C. Elsalanty, Mohammed E. Zakhary, Ibrahim Khashaba, Rania M. Borke, James L. TI Effect of Metformin on Periimplant Wound Healing in a Rat Model of Type 2 Diabetes SO IMPLANT DENTISTRY LA English DT Article DE type 2 diabetes; dental implants; metformin; rat model ID ADVANCED GLYCATION ENDPRODUCTS; DENTAL IMPLANTS; OSTEOBLASTIC CELLS; GLYCEMIC CONTROL; BONE-FORMATION; MELLITUS; OSSEOINTEGRATION; IMPACT; MECHANISMS; SURVIVAL AB Purpose: To investigate the effects of hyperglycemia and metformin (a popular biguanide antidiabetic) on periimplant healing. Methods: Thirty-six male rats were assigned to 3 groups: (1) nondiabetic Wistar-Kyoto rats (controls), (2) Goto-Kakizaki (GK) spontaneously diabetic rats (GK group), and (3) GK rats were fed metformin (100 mg/kg body weight per day) in their water for 4 weeks (GK + Met group). The right maxillary first molars were extracted and sites were allowed 1 month to heal. Titanium implants (1 x 3 mm) were placed in healed extraction sites. Six rats from each group were analyzed at weeks 1 and 4 by micro computed tomography for bone/implant contact ratio, percent bone volume, trabecular number, and bone mineral density. Blood was also analyzed for glucose, HbA1c, and pyridinoline (PYD). Results: At week 1, glucose levels in the GK-Met rats were high, and all bone parameters were similar to GK rats (lower bone parameters and higher PYD than controls). At week 4, glucose levels in the GK-Met rats and all parameters were similar to controls. Conclusions: Hyperglycemic GK type 2 diabetic rats showed improved blood glucose and wound healing around oral implants after metformin administration. C1 [Inouye, Kimberly Ann S.; Elsalanty, Mohammed E.; Zakhary, Ibrahim; Borke, James L.] Georgia Regents Univ, Dept Oral Biol, Augusta, GA USA. [Inouye, Kimberly Ann S.; Bisch, Frederick C.] Ft Gordon, US Army Adv Educ Program Periodont, Augusta, GA USA. [Khashaba, Rania M.] Misr Int Univ, Dept Biomat, Cairo, Egypt. [Borke, James L.] Western Univ Hlth Sci, Coll Dent Med, Pomona, CA 91766 USA. RP Borke, JL (reprint author), Western Univ Hlth Sci, Coll Dent Med, 309 E Second St, Pomona, CA 91766 USA. EM jborke@westernu.edu FU United States Army Advanced Education Program in Periodontics, Fort Gordon, Augusta, GA FX This work was supported by the United States Army Advanced Education Program in Periodontics, Fort Gordon, Augusta, GA. The authors claim to have no financial interest, either directly or indirectly, in the products or information listed in the article. NR 35 TC 4 Z9 5 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1056-6163 J9 IMPLANT DENT JI Implant Dent. PD JUN PY 2014 VL 23 IS 3 BP 319 EP 327 DI 10.1097/ID.0000000000000069 PG 9 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA AI5ID UT WOS:000336898200016 PM 24776941 ER PT J AU Clayton, JD AF Clayton, J. D. TI Analysis of shock compression of strong single crystals with logarithmic thermoelastic-plastic theory SO INTERNATIONAL JOURNAL OF ENGINEERING SCIENCE LA English DT Article DE Shock physics; Elasticity; Plasticity; Finite strain; Crystals ID NONLINEAR ANISOTROPIC DESCRIPTION; FINITE DEFORMATION PLASTICITY; EQUATION-OF-STATE; WAVE-PROPAGATION; ELASTIC-CONSTANTS; THERMOMECHANICAL RESPONSE; DYNAMIC PLASTICITY; ANHARMONIC THEORY; BRITTLE MATERIALS; THIRD-ORDER AB A finite strain theory is developed for anisotropic single crystals undergoing shock loading. Inelastic deformation may arise from dislocation slip, twinning, or fracture and crack sliding. Internal energy can generally depend on a logarithmic measure of finite elastic strain, entropy, and an internal variable associated with defect accumulation. A closed form analytical solution is derived for the planar shock response in the thermoelastic regime, at axial stresses up to the Hugoniot elastic limit. In the plastic regime, for highly symmetric orientations and rate independent shear strength, the Rankine-Hugoniot conditions and constitutive relations can be reduced to a set of algebraic equations that can be solved for the material response. The theory is applied towards planar shock loading of single crystals of sapphire, diamond, and quartz. Logarithmic elasticity is demonstrated to be more accurate (i.e., require fewer higher-order elastic constants) than Lagrangian or Eulerian theories for sapphire, diamond, and Z-cut quartz. Results provide new insight into criteria for initiation of twinning, slip, and/or fracture in these materials as well as their strength degradation when shocked at increasingly higher pressures above the Hugoniot elastic limit. Published by Elsevier Ltd. C1 US Army, Res Lab, RDRL WMP C, Impact Phys, Aberdeen Proving Ground, MD 21005 USA. RP Clayton, JD (reprint author), US Army, Res Lab, RDRL WMP C, Impact Phys, Aberdeen Proving Ground, MD 21005 USA. EM john.d.clayton1.civ@mail.mil RI Clayton, John/C-7760-2009 NR 71 TC 12 Z9 12 U1 0 U2 19 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0020-7225 EI 1879-2197 J9 INT J ENG SCI JI Int. J. Eng. Sci. PD JUN PY 2014 VL 79 BP 1 EP 20 DI 10.1016/j.ijengsci.2014.02.016 PG 20 WC Engineering, Multidisciplinary SC Engineering GA AI6TD UT WOS:000337009000001 ER PT J AU Bear, KA Solomon, BD Antonini, S Arnhold, IJP Franca, MM Gerkes, EH Grange, DK Hadley, DW Jaaskelainen, J Paulo, SS Rump, P Stratakis, CA Thompson, EM Willis, M Winder, TL Jorge, AAL Roessler, E Muenke, M AF Bear, Kelly A. Solomon, Benjamin D. Antonini, Sonir Arnhold, Ivo J. P. Franca, Marcela M. Gerkes, Erica H. Grange, Dorothy K. Hadley, Donald W. Jaaskelainen, Jarmo Paulo, Sabrina S. Rump, Patrick Stratakis, Constantine A. Thompson, Elizabeth M. Willis, Mary Winder, Thomas L. Jorge, Alexander A. L. Roessler, Erich Muenke, Maximilian TI Pathogenic mutations in GLI2 cause a specific phenotype that is distinct from holoprosencephaly SO JOURNAL OF MEDICAL GENETICS LA English DT Article ID SONIC-HEDGEHOG; SPECTRUM; HYPOPITUITARISM; INDIVIDUALS; FREQUENCY; VARIANTS; DEFECTS; DISEASE; GENE; ZIC2 AB Background Mutations in GLI2 have been associated with holoprosencephaly (HPE), a neuroanatomic anomaly resulting from incomplete cleavage of the developing forebrain, and an HPE-like phenotype involving pituitary anomalies and polydactyly. Objective To characterise the genotypic and phenotypic findings in individuals with GLI2 variants and clarify clinical findings in individuals with loss-of-function mutations. Methods Through the National Institutes of Health and collaborating centres, similar to 400 individuals with HPE spectrum disorders, endocrine disorders or craniofacial anomalies were screened for GLI2 mutations. Results were combined with all published cases. We compared the clinical and molecular features of individuals with truncating mutations to individuals with variants of unknown significance (defined as not resulting in protein truncation, reported in normal controls and/or deemed unlikely to be pathogenic by functional prediction software). Results 112 individuals with variants in GLI2 were identified, with 43 having truncating mutations. Individuals with truncating mutations were more likely to have both pituitary anomalies and polydactyly versus those with variants of unknown significance (p<0.0001 by Fisher's exact test); only 1 of 43 had frank HPE. These individuals were more likely to have recognised penetrance (polydactyly or pituitary anomalies or both) than those without truncating mutations (p=0.0036 by Fisher's exact test). A common facial phenotype was seen in individuals (with midface hypoplasia, cleft lip/palate and hypotelorism) with truncating mutations. Conclusions Individuals with truncating mutations in GLI2 typically present with pituitary anomalies, polydactyly and subtle facial features rather than HPE. This will be helpful in screening populations for GLI2 mutations and for counselling affected patients. C1 [Bear, Kelly A.; Solomon, Benjamin D.; Hadley, Donald W.; Roessler, Erich; Muenke, Maximilian] NHGRI, Med Genet Branch, NIH, Bethesda, MD 20892 USA. [Bear, Kelly A.] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. [Solomon, Benjamin D.] Inova Hlth Syst, Inova Translat Med Inst, Div Med Genom, Falls Church, VA USA. [Solomon, Benjamin D.] Inova Hlth Syst, Inova Childrens Hosp, Dept Pediat, Falls Church, VA USA. [Antonini, Sonir; Paulo, Sabrina S.] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pediat, Sao Paulo, Brazil. [Arnhold, Ivo J. P.; Franca, Marcela M.] Univ Sao Paulo, Unidade Endocrinol Desenvolvimento, Lab Hormonios & Genet Mol LIM 42, Hosp Clin,Fac Med,Disciplina Endocrinol, Sao Paulo, Brazil. [Gerkes, Erica H.; Rump, Patrick] Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands. [Grange, Dorothy K.] Washington Univ Schl Mdcn, St Louis, MO USA. [Jaaskelainen, Jarmo] Univ Eastern Finland, Dept Pediat, Kuopio, Finland. [Jaaskelainen, Jarmo] Kuopio Univ Hosp, SF-70210 Kuopio, Finland. [Stratakis, Constantine A.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD USA. [Thompson, Elizabeth M.] Womens & Childrens Hosp, South Australian Clin Genet Serv, SA Pathol, Adelaide, SA, Australia. [Thompson, Elizabeth M.] Univ Adelaide, Dept Paediat, Adelaide, SA, Australia. [Willis, Mary] Naval Med Ctr, Dept Pediat, San Diego, CA USA. [Winder, Thomas L.] Prevent Genet, Marshfield, WI USA. [Jorge, Alexander A. L.] Univ Sao Paulo, Unidade Endocrinol Genet, LIM 25, Disciplina Endocrinol,Hosp Clin,Fac Med, Sao Paulo, Brazil. RP Muenke, M (reprint author), NHGRI, Med Genet Branch, 35 Convent Dr,Bldg 35,Room 1B 203, Bethesda, MD 20892 USA. EM mamuenke@mail.nih.gov RI Jorge, Alexander/C-7697-2012; ARNHOLD, IVO/D-2672-2012; Antonini, Sonir /J-5264-2015 OI Jorge, Alexander/0000-0003-2567-7360; FU Division of Intramural Research, National Human Genome Research Institute, National Institutes of Health, Department of Health and Human Services, USA FX This research was supported by the Division of Intramural Research, National Human Genome Research Institute, National Institutes of Health, Department of Health and Human Services, USA. Pertaining to KAB, the views expressed in this publication are those of the author and do not reflect the official policy or position of the Department of the Army, Department of Defense, or the US Government. Pertaining to MW, the views expressed in this article are those of the author and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense or the United States Government. The authors would like to express their gratitude to the patients and families involved. NR 28 TC 11 Z9 11 U1 0 U2 3 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0022-2593 EI 1468-6244 J9 J MED GENET JI J. Med. Genet. PD JUN PY 2014 VL 51 IS 6 BP 413 EP 418 DI 10.1136/jmedgenet-2013-102249 PG 6 WC Genetics & Heredity SC Genetics & Heredity GA AI4NE UT WOS:000336841300008 PM 24744436 ER PT J AU Friedrich, TL Vessey, WB Schuelke, MJ Mumford, MD Yammarino, FJ Ruark, GA AF Friedrich, Tamara L. Vessey, William B. Schuelke, Matthew J. Mumford, Michael D. Yammarino, Francis J. Ruark, Gregory A. TI Collectivistic leadership and George C. Marshall: A historiometric analysis of career events SO LEADERSHIP QUARTERLY LA English DT Article DE Collective leadership; Military leadership; Historiometric methods; Leadership in teams; Leadership in networks ID SHARED LEADERSHIP; MEMBER EXCHANGE; TEAM EFFECTIVENESS; PERFORMANCE; ORGANIZATIONS; PERSPECTIVE; SCIENCE; WORLD; TIES; CONSEQUENCES AB Many of the prevailing approaches to understanding leadership assume that leadership operates as an individual-level phenomenon, in which one person takes on the role of a leader. However, a number of recently developed leadership models now describe leadership as a shared process. These collectivistic theories present leadership as a dynamic process in which a leader may selectively utilize the skills of followers and distribute elements of the leadership role among these followers as the situation demands. In this study, we conduct an investigation into the viability of core elements of the collectivistic theories through a historiometric analysis of events from the career of a notable leader, George C. Marshall. One hundred and two events from Marshall's career were identified from historical biographies and were then content coded and analyzed with regard to the components of a collectivistic leadership model. The results of this historiometric analysis indicated that there are key antecedents to collectivistic leadership and that the use of this form of leadership can result in positive team outcomes. (C) 2013 Elsevier Inc. All rights reserved. C1 [Friedrich, Tamara L.] Univ Warwick, Coventry CV4 7AL, W Midlands, England. [Vessey, William B.; Mumford, Michael D.] Univ Oklahoma, Norman, OK 73019 USA. [Schuelke, Matthew J.] Air Force Res Lab, Wright Patterson AFB, OH USA. [Yammarino, Francis J.] SUNY Binghamton, Binghamton, NY 13902 USA. [Ruark, Gregory A.] US Army Res Inst, Arlington, VA USA. RP Friedrich, TL (reprint author), Univ Warwick, Warwick Business Sch, Coventry CV4 7AL, W Midlands, England. EM tamara.friedrich@wbs.ac.uk NR 90 TC 7 Z9 7 U1 5 U2 26 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1048-9843 EI 1873-3409 J9 LEADERSHIP QUART JI Leadersh. Q. PD JUN PY 2014 VL 25 IS 3 BP 449 EP 467 DI 10.1016/j.leaqua.2013.10.012 PG 19 WC Psychology, Applied; Management SC Psychology; Business & Economics GA AI5ER UT WOS:000336888700003 ER PT J AU Kaplan, S Cortina, J Ruark, G LaPort, K Nicolaides, V AF Kaplan, Seth Cortina, Jose Ruark, Gregory LaPort, Kate Nicolaides, Vias TI The role of organizational leaders in employee emotion management: A theoretical model SO LEADERSHIP QUARTERLY LA English DT Article DE Emotion; Affect; Leadership; Emotion management; Performance ID AFFECTIVE STATES; TRANSFORMATIONAL LEADERSHIP; ABUSIVE SUPERVISION; WORK ORGANIZATIONS; JOB-PERFORMANCE; INTELLIGENCE; WORKPLACE; BEHAVIOR; SUPPORT; MOOD AB The actions of organizational leaders are important determinants of the emergence, management, and consequences of employee emotional experience. However, the nature and dimensionality of leader emotion management and the behaviors that constitute such management are largely unknown. The authors present a comprehensive, theoretically-derived model of leader emotion management which clarifies the nature of emotion management and its role in leadership. This model also delineates the knowledge and skill-based antecedents of emotion management and the consequences of such management Specifically, we propose linkages between particular KSAOs and specific emotion management dimensions and between those dimensions and particular individual and organizational outcomes. The model is meant to serve as a framework to guide empirical efforts in investigating the nature and correlates of leader emotion management. (C) 2013 Elsevier Inc. All rights reserved. C1 [Kaplan, Seth; Cortina, Jose; Nicolaides, Vias] George Mason Univ, Fairfax, VA 22030 USA. [Ruark, Gregory; LaPort, Kate] US Army Res Inst Behav & Social Sci, Arlington, VA USA. RP Kaplan, S (reprint author), George Mason Univ, Dept Psychol, 4400 Univ Dr,MSN 3 F5, Fairfax, VA 22030 USA. EM Skaplan1@gmu.edu NR 134 TC 7 Z9 9 U1 9 U2 53 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1048-9843 EI 1873-3409 J9 LEADERSHIP QUART JI Leadersh. Q. PD JUN PY 2014 VL 25 IS 3 BP 563 EP 580 DI 10.1016/j.leaqua.2013.11.015 PG 18 WC Psychology, Applied; Management SC Psychology; Business & Economics GA AI5ER UT WOS:000336888700009 ER PT J AU Burgess, E AF Burgess, Edwin TI I Heard My Country Calling: A Memoir SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] US Army, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. RP Burgess, E (reprint author), US Army, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD JUN 1 PY 2014 VL 139 IS 10 BP 120 EP 120 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA AI4JD UT WOS:000336830600197 ER PT J AU Bailey, D AF Bailey, David TI Solar-powered cathodic protection safeguards water tanks in remote area SO MATERIALS PERFORMANCE LA English DT News Item C1 ERDC CERL, Champaign, IL 61822 USA. RP Bailey, D (reprint author), ERDC CERL, Champaign, IL 61822 USA. EM david.m.bailey@usace.army.mil NR 0 TC 0 Z9 0 U1 1 U2 3 PU NATL ASSOC CORROSION ENG PI HOUSTON PA 1440 SOUTH CREEK DRIVE, HOUSTON, TX 77084-4906 USA SN 0094-1492 J9 MATER PERFORMANCE JI Mater. Perform. PD JUN PY 2014 VL 53 IS 6 BP 17 EP 18 PG 2 WC Materials Science, Characterization & Testing SC Materials Science GA AI5WO UT WOS:000336940400003 ER PT J AU Linkov, I Bridges, T Creutzig, F Decker, J Fox-Lent, C Kroger, W Lambert, JH Levermann, A Montreuil, B Nathwani, J Nyer, R Renn, O Scharte, B Scheffler, A Schreurs, M Thiel-Clemen, T AF Linkov, Igor Bridges, Todd Creutzig, Felix Decker, Jennifer Fox-Lent, Cate Kroeger, Wolfgang Lambert, James H. Levermann, Anders Montreuil, Benoit Nathwani, Jatin Nyer, Raymond Renn, Ortwin Scharte, Benjamin Scheffler, Alexander Schreurs, Miranda Thiel-Clemen, Thomas TI Changing the resilience paradigm SO NATURE CLIMATE CHANGE LA English DT Editorial Material ID SYSTEMS; RISK C1 [Linkov, Igor; Fox-Lent, Cate] US Army, Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, Concord, MA 01742 USA. [Bridges, Todd] US Army, Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Creutzig, Felix] Mercator Res Inst Global Commons & Climate Chang, D-10829 Berlin, Germany. [Decker, Jennifer] Embassy Canada, D-10117 Berlin, Germany. [Kroeger, Wolfgang] Swiss Fed Inst Technol Zurich ETH, CH-8092 Zurich, Switzerland. [Lambert, James H.] Univ Virginia, Charlottesville, VA 22903 USA. [Levermann, Anders] Potsdam Inst Climate Impact Res, D-14191 Potsdam, Germany. [Montreuil, Benoit] Univ Laval, Quebec City, PQ G1V 0A6, Canada. [Nathwani, Jatin] Univ Waterloo, Waterloo, ON N2L 3G1, Canada. [Nyer, Raymond] RNC Conseil, F-92200 Neuilly Sur Seine, France. [Nyer, Raymond] Ecole Cent Paris, F-92200 Neuilly Sur Seine, France. [Renn, Ortwin] Univ Stuttgart, D-70174 Stuttgart, Germany. [Scharte, Benjamin] Fraunhofer Inst High Speed Dynam, D-79104 Freiburg, Germany. [Scheffler, Alexander] Hamburg Univ Technol, D-21073 Hamburg, Germany. [Schreurs, Miranda] Free Univ Berlin, D-14195 Berlin, Germany. [Thiel-Clemen, Thomas] Hamburg Univ Appl Sci, D-21033 Hamburg, Germany. RP Linkov, I (reprint author), US Army, Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, 696 Virginia Rd, Concord, MA 01742 USA. EM igor.linkov@usace.army.mil RI Levermann, Anders/G-4666-2011; OI Levermann, Anders/0000-0003-4432-4704; Renn, Ortwin/0000-0002-4681-1752 NR 12 TC 23 Z9 35 U1 2 U2 33 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1758-678X EI 1758-6798 J9 NAT CLIM CHANGE JI Nat. Clim. Chang. PD JUN PY 2014 VL 4 IS 6 BP 407 EP 409 PG 3 WC Environmental Sciences; Environmental Studies; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA AI8EC UT WOS:000337138700005 ER PT J AU Torres, LN Sondeen, J Salgado, C Valdez, C Dubick, MA Filho, IT AF Torres, L. N. Sondeen, J. Salgado, C. Valdez, C. Dubick, M. A. Filho, I. Torres TI ENDOTHELIAL GLYCOCALYX (EG) AFTER SEVERE HEMORRHAGIC SHOCK (HS) FOLLOWED BY PLASMA VOLUME EXPANSION WITH NORMAL SALINE SO SHOCK LA English DT Meeting Abstract CT 37th Annual Conference of the Shock-Society on Shock CY JUN 07-10, 2014 CL Charlotte, NC SP Shock Soc C1 [Torres, L. N.; Sondeen, J.; Salgado, C.; Valdez, C.; Dubick, M. A.; Filho, I. Torres] US Army Inst Surg Res, San Antonio, TX USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2014 VL 41 SU 2 BP 26 EP 26 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA AI6ET UT WOS:000336964600041 ER PT J AU Wu, X Darlington, DN Cap, AP AF Wu, X. Darlington, D. N. Cap, A. P. TI FIBRINOLYTIC ACTIVITY IN PLASMA AFTER POLYTRAUMA AND HEMORRHGE IN RATS SO SHOCK LA English DT Meeting Abstract CT 37th Annual Conference of the Shock-Society on Shock CY JUN 07-10, 2014 CL Charlotte, NC SP Shock Soc C1 [Wu, X.; Darlington, D. N.; Cap, A. P.] US Army Inst Surg Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2014 VL 41 SU 2 BP 52 EP 52 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA AI6ET UT WOS:000336964600114 ER PT J AU Wu, X Darlington, DN Cap, AP AF Wu, X. Darlington, D. N. Cap, A. P. TI THROMBIN INHIBITION AFTER POLYTRAUMA AND HEMORRHAGE IN RATS SO SHOCK LA English DT Meeting Abstract CT 37th Annual Conference of the Shock-Society on Shock CY JUN 07-10, 2014 CL Charlotte, NC SP Shock Soc C1 [Wu, X.; Darlington, D. N.; Cap, A. P.] US Army Inst Surg Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2014 VL 41 SU 2 BP 62 EP 62 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA AI6ET UT WOS:000336964600141 ER PT J AU Darlington, DN Keesee, JD Wu, X Cap, AP AF Darlington, D. N. Keesee, J. D. Wu, X. Cap, A. P. TI PLATELET FUNCTION AFTER POLYTRAUMA AND HEMORRHAGE IN RATS SO SHOCK LA English DT Meeting Abstract CT 37th Annual Conference of the Shock-Society on Shock CY JUN 07-10, 2014 CL Charlotte, NC SP Shock Soc C1 [Darlington, D. N.; Keesee, J. D.; Wu, X.; Cap, A. P.] US Army Inst Surg Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2014 VL 41 SU 2 BP 64 EP 65 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA AI6ET UT WOS:000336964600148 ER PT J AU Dubick, MA Li, Y Grubbs, DL Barr, JL Lucca, JJD AF Dubick, M. A. Li, Y. Grubbs, D. L. Barr, J. L. Lucca, J. J. Dalle TI INFLAMMATORY RESPONSES IN BRAIN FROM SWINE SUBJECTED TO TRAUMATIC HEMORRHAGE AND TREATED WITH A C1 INHIBITOR SO SHOCK LA English DT Meeting Abstract CT 37th Annual Conference of the Shock-Society on Shock CY JUN 07-10, 2014 CL Charlotte, NC SP Shock Soc C1 [Dubick, M. A.; Li, Y.; Grubbs, D. L.; Barr, J. L.; Lucca, J. J. Dalle] US Army Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2014 VL 41 SU 2 BP 65 EP 65 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA AI6ET UT WOS:000336964600149 ER PT J AU Meyer, RR Bhattacharjee, M Varghese, N Sharma, M Pusateri, AE Brownstein, BH AF Meyer, R. R. Bhattacharjee, M. Varghese, N. Sharma, M. Pusateri, A. E. Brownstein, B. H. TI SERIAL ANALYSIS OF TRAUMA PATIENT LEUKOCYTE MRNAS ENCODING PROTEINS INVOLVED IN COAGULATION SO SHOCK LA English DT Meeting Abstract CT 37th Annual Conference of the Shock-Society on Shock CY JUN 07-10, 2014 CL Charlotte, NC SP Shock Soc C1 [Meyer, R. R.; Bhattacharjee, M.; Varghese, N.; Sharma, M.; Brownstein, B. H.] Washington Univ, Sch Med, St Louis, MO USA. [Pusateri, A. E.] US Army Med Res & Mat Command, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2014 VL 41 SU 2 BP 80 EP 80 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA AI6ET UT WOS:000336964600193 ER PT J AU Wu, X Darlington, DN Schwacha, MG Cap, AP AF Wu, X. Darlington, D. N. Schwacha, M. G. Cap, A. P. TI THE DEVELOPMENT OF ACUTE LUNG INJURY AFTER POLYTRAUMA AND HEMORRHAGE IN RATS SO SHOCK LA English DT Meeting Abstract CT 37th Annual Conference of the Shock-Society on Shock CY JUN 07-10, 2014 CL Charlotte, NC SP Shock Soc C1 [Wu, X.; Darlington, D. N.; Schwacha, M. G.; Cap, A. P.] US Army Inst Surg Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2014 VL 41 SU 2 BP 90 EP 90 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA AI6ET UT WOS:000336964600220 ER PT J AU Martini, WZ Chung, KK Dubick, MA AF Martini, W. Z. Chung, K. K. Dubick, M. A. TI COMPARISONS OF NORMAL SALINE AND LACTATED RINGER'S IN NORMAL AND HYPOTENSIVE RESUSCITATION IN PIGS AFTER HEMORRHAGIC SHOCK SO SHOCK LA English DT Meeting Abstract CT 37th Annual Conference of the Shock-Society on Shock CY JUN 07-10, 2014 CL Charlotte, NC SP Shock Soc C1 [Martini, W. Z.; Chung, K. K.; Dubick, M. A.] US Army Inst Surg Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JUN PY 2014 VL 41 SU 2 BP 94 EP 94 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA AI6ET UT WOS:000336964600233 ER PT J AU Morrison, JJ Stannard, A Midwinter, MJ Sharon, DJ Eliason, JL Rasmussen, TE AF Morrison, Jonathan J. Stannard, Adam Midwinter, Mark J. Sharon, Danny J. Eliason, Jonathan L. Rasmussen, Todd E. TI Prospective evaluation of the correlation between torso height and aortic anatomy in respect of a fluoroscopy free aortic balloon occlusion system SO SURGERY LA English DT Article ID PENETRATING ABDOMINAL-TRAUMA; COMBAT CASUALTY CARE; HEMORRHAGIC-SHOCK; RESUSCITATIVE THORACOTOMY; ANEURYSMS; IMPACT; DEATH; MODEL AB Background. To report the lengths of key torso vascular and to develop regression models that will predict these lengths, based on an external measure of torso height (EMTH, sternum to pubis) in the development of a fluoroscopy-free balloon occlusion system for hemorrhage control. Methods. We conducted a prospective, observational study at a Combat Support Hospital in Southern Afghanistan using adult male patients undergoing computed tomography (CT). EMTH was recorded using a tape measure and intra-arterial distance was derived from CT imaging. Regression models to predict distance from the common femoral artery (CFA) into the middle of aortic zone I (left subclavian artery to celiac trunk) and zone III (infrarenal aorta) were developed from a random 20% of the cohort and validated by the remaining 80%. Results. Overall, 177 male patients were included with a median (interquartile range [IQR]) age Of 23 (8) years. The median (IQR) lengths of aortic zone I and III were 222 (24), 31 (9), and 92 (15) mm. The mid-zone distance from the left and right CFA to zone I were 423 (27) and 418 (29) and for zone III 232 (21) and 228 (22). Linear regression models demonstrated an accuracy between 99.3% to 100% at predicting the insertion distance required to place a catheter within the middle of each aortic zone. Conclusion. This study demonstrates the use of morphometric analysis in the development of a fluoroscopy-free balloon occlusion system for torso hemorrhage control. Further study in a larger population of mixed gender is required to further validate insertion models. C1 [Morrison, Jonathan J.; Stannard, Adam; Midwinter, Mark J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. [Morrison, Jonathan J.; Rasmussen, Todd E.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Morrison, Jonathan J.] Glasgow Royal Infirm, Acad Surg Unit, Glasgow G4 0SF, Lanark, Scotland. [Sharon, Danny J.] Joint Base San Antonio Lackland, Air Force Med Support Agency, Lackland AFB, TX 78236 USA. [Eliason, Jonathan L.] Univ Michigan, Div Vasc Surg, Ann Arbor, MI 48109 USA. [Rasmussen, Todd E.] Joint Base San Antonio Lackland, Med Wing 59th, Lackland AFB, TX USA. [Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. RP Rasmussen, TE (reprint author), Deputy Commander US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM todd.e.rasmussen.mil@mail.mil RI Midwinter, Mark/P-6264-2015; OI Midwinter, Mark/0000-0003-1836-7137; Morrison, Jonathan/0000-0001-7462-8456 NR 20 TC 5 Z9 5 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0039-6060 J9 SURGERY JI Surgery PD JUN PY 2014 VL 155 IS 6 BP 1044 EP 1051 DI 10.1016/j.surg.2013.12.036 PG 8 WC Surgery SC Surgery GA AI6RW UT WOS:000337005700013 PM 24856124 ER PT J AU Watson, JDB Aden, JK Engel, JE Rasmussen, TE Glasgow, SC AF Watson, J. Devin B. Aden, James K. Engel, Julie E. Rasmussen, Todd E. Glasgow, Sean C. TI Risk factors for colostomy in military colorectal trauma: A review of 867 patients SO SURGERY LA English DT Article; Proceedings Paper CT 8th Annual Academic Surgical Congress CY FEB 05-07, 2013 CL New Orleans, LA SP Assoc Acad Surg, Soc Univ Surg ID OPERATION IRAQI FREEDOM; DAMAGE CONTROL LAPAROTOMY; PRIMARY ANASTOMOSIS; RECTAL INJURIES; CONTROL SURGERY; COLON INJURIES; MANAGEMENT; COMBAT; CASUALTIES; OUTCOMES AB Background. Limited data exist examining the use of fecal diversion in combatants from modern armed conflicts. Characterization of factors leading to colostomy creation is an initial step toward optimizing and individualizing combat casualty care. Methods. A retrospective review of the US Department of Defense Trauma Registry database was performed for all US and coalition troops with colorectal injuries sustained during combat operations in Iraq and Afghanistan over 8 years. Colostomy rate, anatomic injury location, mechanism of injury, demographic data, and initial physiologic parameters were examined. Univariate and multivariate analyses were conducted. Results. We identified 867 coalition military personnel with colorectal injuries. The overall colostomy rate was 37%. Rectal injuries had the highest diversion rate (56%), followed by left-sided (41%) and right-sided (20%) locations (P < .0001). Those with gunshot wounds (GSW) underwent diversion more often than blast injuries (43% vs 31% respectively, P < .0008). Injury Severity Score >= 16 (41% vs 30%; P = .0018) and damage control surgery (DCS; 48.2% vs 31.4%; P < .0001) were associated with higher diversion rates. On multivariate analysis, significant predictors for colostomy creation were injury location: Rectal versus left colon (odds ratio [OR], 2.2), rectal versus right colon (OR, 7.5), left versus right colon (OR, 3.4), GSW (OR, 2.0), ISS >= 16 (OR, 1.7), and DCS (OR, 1.6). Conclusion. In this exploratory study of 320 combat-related colostomies, distal colon and rectal injuries continue to be diverted at higher rates independent of other comorbidities. Additional outcomes-directed research is needed to determine whether such operative management is beneficial in all patients. C1 [Watson, J. Devin B.; Glasgow, Sean C.] San Antonio Mil Med Ctr, Dept Surg, Ft Sam Houston, TX USA. [Watson, J. Devin B.; Aden, James K.; Engel, Julie E.; Rasmussen, Todd E.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. [Glasgow, Sean C.] St Louis Univ, Dept Surg, St Louis, MO 63103 USA. RP Glasgow, SC (reprint author), 3635 Vista Ave Grand Blvd,3rd Floor,Desloge Tower, St Louis, MO 63110 USA. EM glasgowsc@slu.edu NR 27 TC 4 Z9 4 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0039-6060 J9 SURGERY JI Surgery PD JUN PY 2014 VL 155 IS 6 BP 1052 EP 1061 DI 10.1016/j.surg.2014.01.010 PG 10 WC Surgery SC Surgery GA AI6RW UT WOS:000337005700014 PM 24856125 ER PT J AU Morgan, TR AF Morgan, Theodore R. TI Evaluation of Fluid Bolus Administration Rates Using Ruggedized Field Intravenous Systems SO WILDERNESS & ENVIRONMENTAL MEDICINE LA English DT Article DE ruggedized field IV; Ranger IV; saline lock; tactical combat casualty care (TCCC); fluid resuscitation; pressure infusion AB Objective.-The purpose of this study was to evaluate 2 ruggedized field intravenous (IV) systems currently in use by US military medics and to determine their effect on fluid bolus administration rates. Methods.-A series of 500 mL fluid boluses consisting of either Lactated Ringer's solution or Hextend were delivered to 2 artificial intravenous training arms using a standard 18G catheter (control) and 2 separate ruggedized field IV systems. Fluid boluses were delivered under both gravity force and pressure infusion (constant 300 mm Hg), and total bolus times were recorded. Results.-Using Lactated Ringer's solution, the standard IV system took a mean time of 9:33 minutes (95% CI: 9:13-9:54) to deliver a 500 mL fluid bolus whereas the 2 ruggedized field systems took mean times of 14:50 minutes (95% CI: 14:00-15:40) and 12:20 minutes (95% CI: 11:54-12:45). Using Hextend, the mean bolus time for the control system was 24:39 minutes (95% CI: 22:47-26:32). The 2 ruggedized field systems required an average of 49:32 minutes (95% CI: 48:07-50:58) and 39:46 minutes (95% CI: 37:30-42:01) to deliver an equivalent bolus. Pressure infusion significantly increased flow rate in all systems. Conclusions.-Ruggedized field IV systems can significantly delay fluid bolus rates. In instances where ruggedized field systems are deemed necessary, pressure infusion devices should be considered to overcome the constrictive effects of the ruggedized system. C1 [Morgan, Theodore R.] US Army Special Warfare Med Grp Airborne, Ft Bragg, NC USA. RP Morgan, TR (reprint author), 36 Myst Lane, Lillington, NC 27546 USA. EM theodore.ross.morgan@gmail.com NR 10 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1080-6032 EI 1545-1534 J9 WILD ENVIRON MED JI Wildern. Environ. Med. PD SUM PY 2014 VL 25 IS 2 BP 204 EP 209 PG 6 WC Public, Environmental & Occupational Health; Sport Sciences SC Public, Environmental & Occupational Health; Sport Sciences GA AI5YL UT WOS:000336946800012 PM 24631229 ER PT J AU Sontgerath, JS Rubal, BJ DeLorenzo, RA Morgan, TL Ward, JA AF Sontgerath, Joseph S. Rubal, Bernard J. DeLorenzo, Robert A. Morgan, Trent L. Ward, John A. TI Variability in intraosseous flush practices of emergency physicians SO AMERICAN JOURNAL OF EMERGENCY MEDICINE LA English DT Article ID BONE-MARROW; INFUSION RATES; FAT-EMBOLISM; CLINICAL RELEVANCE; VASCULAR ACCESS; SWINE MODEL; PRESSURE; BLOOD; ECHOCARDIOGRAPHY; SAFETY AB IncObjective: Intramedullary pressure changes during intraosseous (IO) procedures have been implicated in the intravasation of bone marrow fat and with pain in conscious patients. The objective of this study was to demonstrate inter-provider variability in pressures generated during initial flush procedures. Methods: IO cannulas were inserted into the proximal tibiae and humeri by study personnel. A second cannula was placed in the mid diaphysis of each bone to record intramedullary pressures. Fifteen emergency physicians performed 60 flushes in random order in two cadavers while flush duration and IO pressure were continuously recorded. Providers were blinded to the flush pressures they generated and the flush techniques of others. Results: The median IO pressure (IOP) generated by providers was 903 mm Hg (range, 83-2941 mm Hg) and the median flush duration was 5.2 seconds (range, 1.0-13.4 seconds). Significant differences were noted among providers in peak IOP generated (analysis of variance P<.001). Providers were consistent in the forces they generated relative to each other. An inverse, nonlinear relationship was observed between flush duration and the peak IOP generated. Significant differences were noted in intramedullary flush pressures at flush sites within cadavers (analysis of variance P: cadaver #1 P<.001; cadaver #2 P=.012). Conclusions: The IO compartment pressures generated by physicians demonstrated significant interoperator variability with greater than 35-fold difference in flush forces, and an inverse relationship between intraosseous pressure and flush duration. It may be prudent practice for providers to extend the flush over several seconds, thus limiting maximal pressures. Published by Elsevier Inc. C1 [Sontgerath, Joseph S.; Morgan, Trent L.] Dept Emergency Med, Ft Sam Houston, TX 78234 USA. [Rubal, Bernard J.; Ward, John A.] San Antonio Mil Med Ctr, Serv Cardiol, Ft Sam Houston, TX 78234 USA. [DeLorenzo, Robert A.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Sontgerath, JS (reprint author), Mike OCallaghan Fed Med Ctr, Dept Emergency Med, 4700 N Las Vegas Blvd, Nellis Afb, NV 89191 USA. EM joseph.sontgerath.1@us.af.mil FU US Army Tele-medicine and Advanced Technology Research Center FX Funding was provided by the US Army Tele-medicine and Advanced Technology Research Center. NR 36 TC 2 Z9 2 U1 0 U2 2 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0735-6757 EI 1532-8171 J9 AM J EMERG MED JI Am. J. Emerg. Med. PD JUN PY 2014 VL 32 IS 6 BP 665 EP 669 DI 10.1016/j.ajem.2014.03.001 PG 5 WC Emergency Medicine SC Emergency Medicine GA AI1AK UT WOS:000336581800035 PM 24725773 ER PT J AU Lewis, CL Craig, CC Senecal, AG AF Lewis, Christina L. Craig, Caelli C. Senecal, Andre G. TI Mass and Density Measurements of Live and Dead Gram-Negative and Gram-Positive Bacterial Populations SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID LISTERIA-MONOCYTOGENES; ESCHERICHIA-COLI; INDIVIDUAL CELLS; IMAGE-ANALYSIS; SINGLE CELLS; GROWTH; DISTRIBUTIONS; TIMES; MICROSCOPY; DIVISION AB Monitoring cell growth and measuring physical features of food-borne pathogenic bacteria are important for better understanding the conditions under which these organisms survive and proliferate. To address this challenge, buoyant masses of live and dead Escherichia coli O157:H7 and Listeria innocua were measured using Archimedes, a commercially available suspended microchannel resonator (SMR). Cell growth was monitored with Archimedes by observing increased cell concentration and buoyant mass values of live growing bacteria. These growth data were compared to optical density measurements obtained with a Bioscreen system. We observed buoyant mass measurements with Archimedes at cell concentrations between 10(5) and 10(8) cells/ml, while growth was not observed with optical density measurements until the concentration was 10(7) cells/ml. Buoyant mass measurements of live and dead cells with and without exposure to hydrogen peroxide stress were also compared; live cells generally had a larger buoyant mass than dead cells. Additionally, buoyant mass measurements were used to determine cell density and total mass for both live and dead cells. Dead E. coli cells were found to have a larger density and smaller total mass than live E. coli cells. In contrast, density was the same for both live and dead L. innocua cells, while the total mass was greater for live than for dead cells. These results contribute to the ongoing challenge to further develop existing technologies used to observe cell populations at low concentrations and to measure unique physical features of cells that may be useful for developing future diagnostics. C1 [Lewis, Christina L.; Craig, Caelli C.; Senecal, Andre G.] US Army Natick Soldier Res, Food Protect Team, Combat Feeding Directorate, Ctr Dev & Engn, Natick, MA 01760 USA. RP Lewis, CL (reprint author), US Army Natick Soldier Res, Food Protect Team, Combat Feeding Directorate, Ctr Dev & Engn, Natick, MA 01760 USA. EM christina.l.lewis23.ctr@mail.mil FU National Research Council FX This research was performed while author Christina L. Lewis held a National Research Council Research Associateship Award at Natick Soldier Research, Development, and Engineering Center. NR 26 TC 4 Z9 4 U1 5 U2 22 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 EI 1098-5336 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD JUN PY 2014 VL 80 IS 12 BP 3622 EP 3631 DI 10.1128/AEM.00117-14 PG 10 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA AI3EX UT WOS:000336744000009 PM 24705320 ER PT J AU Fowler, M Clifford, JL Garza, TH Slater, TM Arizpe, HM Novak, J Petz, LN Loyd, DR AF Fowler, Marcie Clifford, John L. Garza, Thomas H. Slater, Terry M. Arizpe, Helen M. Novak, Joseph Petz, Lawrence N. Loyd, Dayna R. TI A rat model of full thickness thermal injury characterized by thermal hyperalgesia, mechanical allodynia, pronociceptive peptide release and tramadol analgesia SO BURNS LA English DT Article DE Pain; Burn; Opioid analgesia; CGRP; Substance P ID GENE-RELATED PEPTIDE; HINDPAW BURN INJURY; SECONDARY HYPERALGESIA; NEUROPATHIC PAIN; PERIAQUEDUCTAL GRAY; SUBSTANCE-P; SOMATOTOPIC ORGANIZATION; RECEPTOR ANTAGONIST; POSTOPERATIVE PAIN; MORPHINE ANALGESIA AB Opioid-related side effects are problematic for burn patients. Dual mechanism therapeutics targeting opioid and non-opioid mechanisms may have reduced side effects with similar analgesic efficacy. Tramadol combines mu opioid receptor agonism with norepinephrine reuptake inhibition and has been effective in treating some types of pain. The effectiveness of tramadol in treating pain associated with burns is unclear. We hypothesized that tramadol is effective in reducing thermal injury-evoked pain behaviors in a rat model. Rats were anesthetized and a 100 degrees C metal probe was placed on the hindpaw for 30 s to induce a full thickness thermal injury. A subset of rats was perfusion fixed and hindpaw tissue and spinal cord collected for anatomical analysis. Rats received morphine (5 mg/kg; i.p.), tramadol (10-30 mg/kg; i.p.) or vehicle and latency to paw withdrawal from a noxious thermal or non-noxious mechanical stimulus was recorded every 10 min over 70 min and again at 2 h. We report that pain behaviors developed within 48 h and peaked at 1 week; paralleled by enhanced expression of pronociceptive neuropeptides in the spinal cord. Morphine and tramadol significantly attenuated hyperalgesia and allodynia, while not significantly altering motor coordination/sedation. These data indicate dual mechanism therapeutics may be effective for treating pain associated with burns. Published by Elsevier Ltd and ISBI C1 [Fowler, Marcie; Clifford, John L.; Garza, Thomas H.; Slater, Terry M.; Arizpe, Helen M.; Petz, Lawrence N.; Loyd, Dayna R.] US Army Inst Surg Res, Pain Management Res Area, JBSA, Ft Sam Houston, TX 78234 USA. [Novak, Joseph] US Army Inst Surg Res, JBSA, Ft Sam Houston, TX 78234 USA. RP Loyd, DR (reprint author), US Army Inst Surg Res, Pain Management Res Area, JBSA, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM dayna.l.averitt.civ@mail.mil OI Averitt, Dayna/0000-0001-8345-4988; Loyd, Dayna/0000-0002-5635-185X FU United States Army Medical Research and Materiel Command Combat Casualty Care Research; Clinical and Rehabilitative Medicine Research programs FX The authors would like to acknowledge the technical assistance of Zach Silvias, Angie Greer and Alberto Mares. We thank Drs. Kenneth M. Hargreaves and Laura McGhee for helpful comments on study design. This work was supported by the United States Army Medical Research and Materiel Command Combat Casualty Care Research and the Clinical and Rehabilitative Medicine Research programs. NR 53 TC 8 Z9 8 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 EI 1879-1409 J9 BURNS JI Burns PD JUN PY 2014 VL 40 IS 4 BP 759 EP 771 DI 10.1016/j.burns.2013.10.011 PG 13 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA AI2QN UT WOS:000336703200031 PM 24290856 ER PT J AU Williams, KS Andzelm, JW Dong, H Snyder, JF AF Williams, Kristen S. Andzelm, Jan W. Dong, Hong Snyder, James F. TI DFT study of metal cation-induced hydrogelation of cellulose nanofibrils SO CELLULOSE LA English DT Article DE Cellulose nanofibrils; Hydrogels; Carboxylate; Molecular modeling; Density functional theory; Implicit solvation model ID DENSITY-FUNCTIONAL CALCULATIONS; GEOMETRY OPTIMIZATION; I-BETA; SURFACES AB We report a density functional theory study of cation-induced bonding between carboxylated cellulose nanofibrils (CNFs). We describe a methodology of using cleaved cellulose crystal unit cells to develop simple surface and molecular models of charged CNFs. We compare bond lengths, binding energies, and displaced solvation volumes for interfibril models intercalated with alkali, alkaline earth, main group, or transition metal cations, surrounded by an implicit solvent. We characterize the type of bonding interactions that occur between metal cations, Mn+ and carboxylated CNF surfaces by calculating the electronic density of states and Mayer bond orders. We find that Mn+-O interactions for alkaline earth metal systems are predominantly electrostatic whereas transition metal cations form stronger, more covalent bonds with enhanced valence orbital overlap. Our results show that multivalent-as opposed to monovalent-ions can create CNF networks by effectively crosslinking multiple fibrils through surface carboxylate anions. Our computational results agree with empirical models of metal-carboxylate binding, while also providing a deeper understanding of the bonding mechanisms for different cations. Our findings help to explain trends in recent CNF hydrogelation experiments, and we also predict the existence of two new hydrogels-CNF-Mg2+ and CNF-Zr4+. C1 [Williams, Kristen S.; Andzelm, Jan W.; Dong, Hong; Snyder, James F.] US Army Res Lab, Macromol Sci & Technol Branch, Aberdeen Proving Ground, MD 21005 USA. [Dong, Hong] Bowhead Sci & Technol LLC, Belcamp, MD 21017 USA. RP Williams, KS (reprint author), US Army Res Lab, Macromol Sci & Technol Branch, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. EM kristen.s.williams7.ctr@mail.mil NR 30 TC 2 Z9 2 U1 6 U2 34 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0969-0239 EI 1572-882X J9 CELLULOSE JI Cellulose PD JUN PY 2014 VL 21 IS 3 BP 1091 EP 1101 DI 10.1007/s10570-014-0254-y PG 11 WC Materials Science, Paper & Wood; Materials Science, Textiles; Polymer Science SC Materials Science; Polymer Science GA AH7OL UT WOS:000336322800002 ER PT J AU Conner, JC Olsen, MJ AF Conner, Jeremy C. Olsen, Michael J. TI Automated quantification of distributed landslide movement using circular tree trunks extracted from terrestrial laser scan data SO COMPUTERS & GEOSCIENCES LA English DT Article DE Laser scanning; LIDAR; Landslide; Coastal; Erosion; Topography; Deformation modeling ID EROSION; CALIFORNIA AB This manuscript presents a novel algorithm to automatically detect landslide movement in a forested area using displacements of tree trunks distributed across the landslide surveyed repeatedly using terrestrial laser scanning (TLS). Common landslide monitoring techniques include: inclinometers, global position system (GPS), and interferometric synthetic aperture radar (InSAR). While these techniques provide valuable data for monitoring landslides, they can be difficult to apply with adequate spatial or temporal resolution needed to understand complex landslides, specifically in forested environments. Comparison of the center coordinates (determined via least-squares fit of the TLS data) of a cross section of the tree trunk between consecutive surveys enable quantification of landslide movement rates, which can be used to analyze patterns of landslide displacement The capabilities of this new methodology were tested through a case-study analyzing the Johnson Creek Landslide, a complex, quick moving coastal landslide, which has proven difficult to monitor using other techniques. A parametric analysis of fitting thresholds was also conducted to determine the reliability of tree trunk displacements calculated and the number of features that were extracted. The optimal parameters in selecting trees for movement analysis were found to be less than 1.5 cm for the RMS residuals of the circle fit and less than 1.0 cm for the difference in the calculated tree radii between epochs. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Conner, Jeremy C.] US Mil Acad, Dept Geog & Environm Engn, West Point, NY 10966 USA. [Olsen, Michael J.] Oregon State Univ, Sch Civil & Construct Engn, Corvallis, OR 97331 USA. RP Olsen, MJ (reprint author), Oregon State Univ, Sch Civil & Construct Engn, 220 Owen Hall, Corvallis, OR 97331 USA. EM jeremy.conner1@us.army.mil; michael.olsen@oregonstate.edu FU United States Army; Oregon Department of Transportation [SPR 740] FX The authors would like to thank Leica Geosystems, David Evans & Associates, and Maptek I-Site for providing the equipment and software used for this research. Additionally, the United States Army, Eric HI and Janice Hoffman and Oregon Department of Transportation (SPR 740) provided funding for this study. Thank you to Jonathan Allan and George Priest for a thorough Johnson Creek Landslide site visit physically showing and explaining previous work done and the geological setting. Thank you to Keith Williams, Rubini Mahalingam, and John Raugust for assistance with data collection. NR 30 TC 3 Z9 3 U1 4 U2 27 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0098-3004 EI 1873-7803 J9 COMPUT GEOSCI-UK JI Comput. Geosci. PD JUN PY 2014 VL 67 BP 31 EP 39 DI 10.1016/j.cageo.2014.02.007 PG 9 WC Computer Science, Interdisciplinary Applications; Geosciences, Multidisciplinary SC Computer Science; Geology GA AI3QZ UT WOS:000336778300004 ER PT J AU Stewart, IJ Sosnov, JA Chung, KK AF Stewart, Ian J. Sosnov, Jonathan A. Chung, Kevin K. TI Vasopressin, Sepsis, and Renal Perfusion-A VASST Deficit in Our Understanding SO CRITICAL CARE MEDICINE LA English DT Editorial Material DE acute kidney injury; renal blood flow; sepsis; shock; vasopressin ID ACUTE KIDNEY INJURY; SEVERE SEPTIC SHOCK; ARGININE-VASOPRESSIN; NOREPINEPHRINE; INFUSION C1 [Stewart, Ian J.; Sosnov, Jonathan A.] San Antonio Mil Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. [Chung, Kevin K.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Stewart, IJ (reprint author), San Antonio Mil Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. NR 15 TC 1 Z9 1 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 EI 1530-0293 J9 CRIT CARE MED JI Crit. Care Med. PD JUN PY 2014 VL 42 IS 6 BP 1583 EP 1584 DI 10.1097/CCM.0000000000000354 PG 2 WC Critical Care Medicine SC General & Internal Medicine GA AH6UM UT WOS:000336266900069 PM 24836811 ER PT J AU Snider, TH Perry, MR Richter, WR Plahovinsak, JL Rogers, J Reid, FM Graham, JS AF Snider, Thomas H. Perry, Mark R. Richter, William R. Plahovinsak, Jennifer L. Rogers, James Reid, Frances M. Graham, John S. TI A dynamic system for delivering controlled bromine and chlorine vapor exposures to weanling swine skin SO CUTANEOUS AND OCULAR TOXICOLOGY LA English DT Article DE Bromine; chlorine; cutaneous; dermal; halogen; injury; model; vapor ID SULFUR MUSTARD; CHEMICAL BURNS; MODEL; PIG AB Context: Assessing the hazards of accidental exposure to toxic industrial chemical (TIC) vapors and evaluating therapeutic compounds or treatment regimens require the development of appropriate animal models. Objective: The objective of this project was to develop an exposure system for delivering controlled vapor concentrations of TICs to the skin of anesthetized weanling pigs. Injury levels targeted for study were superficial dermal (SD) and deep dermal (DD) skin lesions as defined histopathologically. Materials and methods: The exposure system was capable of simultaneously delivering chlorine or bromine vapor to four, 3-cm diameter exposure cups placed over skin between the axillary and inguinal areas of the ventral abdomen. Vapor concentrations were generated by mixing saturated bromine or chlorine vapor with either dried dilution air or nitrogen. Results: Bromine exposure concentrations ranged from 6.5 x 10(-4) to 1.03 g/L, and exposure durations ranged from 1 to 45 min. A 7-min skin exposure to bromine vapors at 0.59 g/L was sufficient to produce SD injuries, while a 17-min exposure produced a DD injury. Chlorine exposure concentrations ranged from 1.0 to 2.9 g/L (saturated vapor concentration) for exposures ranging from 3 to 90 min. Saturated chlorine vapor challenges for up to 30 min did not induce significant dermal injuries, whereas saturated chlorine vapor with wetted material on the skin surface for 30-60 min induced SD injuries. DD chlorine injuries could not be induced with this system. Conclusion: The vapor exposure system described in this study provides a means for safely regulating, quantifying and delivering TIC vapors to the skin of weanling swine as a model to evaluate therapeutic treatments. C1 [Snider, Thomas H.; Perry, Mark R.; Richter, William R.; Plahovinsak, Jennifer L.; Rogers, James; Reid, Frances M.] Battelle Mem Inst, Biomed Res Ctr, Columbus, OH 43201 USA. [Graham, John S.] US Army, Med Res Inst Chem Def, Aberdeen, MD USA. RP Snider, TH (reprint author), Battelle Mem Inst, Biomed Res Ctr, 505 King Ave, Columbus, OH 43201 USA. EM snidert@battelle.org FU US Army Medical Research and Materiel Command [W81XWH-05-D-0001]; US Army Medical Research Institute of Chemical Defense (USAMRICD); National Institutes of Health, National Institute of Allergies and Infectious Disease (NIAID), IAA [Y1-AI-6177-02] FX The authors have no known conflicts of interest. This work was supported by the US Army Medical Research and Materiel Command under Contract W81XWH-05-D-0001, Task Order 0010 with funding support through an Interagency Agreement (IAA) between the US Army Medical Research Institute of Chemical Defense (USAMRICD) and National Institutes of Health, National Institute of Allergies and Infectious Disease (NIAID), IAA Number Y1-AI-6177-02. NR 24 TC 3 Z9 3 U1 0 U2 1 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1556-9527 EI 1556-9535 J9 CUTAN OCUL TOXICOL JI Cutan. Ocul. Toxicol. PD JUN PY 2014 VL 33 IS 2 BP 161 EP 167 DI 10.3109/15569527.2013.806524 PG 7 WC Ophthalmology; Toxicology SC Ophthalmology; Toxicology GA AI3AV UT WOS:000336731700016 PM 23808400 ER PT J AU Russell, DW Russell, CA Riviere, LA Thomas, JL Wilk, JE Bliese, PD AF Russell, Dale W. Russell, Cristel Antonia Riviere, Lyndon A. Thomas, Jeffrey L. Wilk, Joshua E. Bliese, Paul D. TI Changes in alcohol use after traumatic experiences: The impact of combat on Army National Guardsmen SO DRUG AND ALCOHOL DEPENDENCE LA English DT Article DE Alcohol; Longitudinal; Military; National Guard ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS; MORTALITY SALIENCE; DRINKING MOTIVES; SELF-ESTEEM; SOLDIERS; DEPLOYMENT; MILITARY; GROWTH; IRAQ AB Objective: This research documents the impact of combat experiences on alcohol use and misuse among National Guard soldiers. Whereas much research regarding combat personnel is based on post-experience data, this study's design uses both pre- and post-deployment data to identify the association between different types of combat experiences and changes in substance use and misuse. Method: A National Guard Infantry Brigade Combat Team was surveyed before and after its deployment to Iraq in 2005-2006. Members of the unit completed anonymous surveys regarding behavioral health and alcohol use and, in the post-survey, the combat experiences they had during deployment. The unit was surveyed 3 months prior to its deployment and 3 months after its deployment. Results: Prevalence rates of alcohol use increased from 70.8% pre-deployment to 80.5% post-deployment. Prevalence rates of alcohol misuse more than doubled, increasing from 8.51% before deployment to 19.15% after deployment. However, among the combat experiences examined in this study, changes in alcohol misuse post-deployment appear to be solely affected by the combat experience of killing. Alcohol misuse decreased amongst those who experienced killing during combat. Conclusions: This study highlights the role of combat experiences on substance use. Published by Elsevier Ireland Ltd. C1 [Russell, Dale W.; Riviere, Lyndon A.; Thomas, Jeffrey L.; Wilk, Joshua E.; Bliese, Paul D.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Russell, Cristel Antonia] Amer Univ, Washington, DC 20016 USA. [Russell, Dale W.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Psychiat, Bethesda, MD 20814 USA. RP Russell, DW (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM dale.w.russell1.mil@mail.mil OI RUSSELL, CRISTEL/0000-0002-1918-6381 FU Military Operational Medicine Research Area Directorate, U.S. Army Medical Research and Materiel Command, Ft. Detrick, MD FX Funding for this project came from the Military Operational Medicine Research Area Directorate, U.S. Army Medical Research and Materiel Command, Ft. Detrick, MD. NR 57 TC 1 Z9 1 U1 1 U2 16 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0376-8716 EI 1879-0046 J9 DRUG ALCOHOL DEPEN JI Drug Alcohol Depend. PD JUN 1 PY 2014 VL 139 BP 47 EP 52 DI 10.1016/j.drugalcdep.2014.03.004 PG 6 WC Substance Abuse; Psychiatry SC Substance Abuse; Psychiatry GA AI2SI UT WOS:000336708000007 PM 24685562 ER PT J AU Tschopp, MA Murdoch, HA Kecskes, LJ Darling, KA AF Tschopp, M. A. Murdoch, H. A. Kecskes, L. J. Darling, K. A. TI "Bulk" Nanocrystalline Metals: Review of the Current State of the Art and Future Opportunities for Copper and Copper Alloys SO JOM LA English DT Article ID TILT GRAIN-BOUNDARIES; SEVERE PLASTIC-DEFORMATION; CENTERED-CUBIC METALS; CHANNEL ANGULAR EXTRUSION; STRAIN-RATE SENSITIVITY; SCANNING THERMAL MICROSCOPY; MECHANICAL ATTRITION TREATMENT; MOLECULAR-DYNAMICS SIMULATION; COHERENT TWIN BOUNDARIES; STACKING-FAULT ENERGIES AB It is a new beginning for innovative fundamental and applied science in nanocrystalline materials. Many of the processing and consolidation challenges that have haunted nanocrystalline materials are now more fully understood, opening the doors for bulk nanocrystalline materials and parts to be produced. While challenges remain, recent advances in experimental, computational, and theoretical capability have allowed for bulk specimens that have heretofore been pursued only on a limited basis. This article discusses the methodology for synthesis and consolidation of bulk nanocrystalline materials using mechanical alloying, the alloy development and synthesis process for stabilizing these materials at elevated temperatures, and the physical and mechanical properties of nanocrystalline materials with a focus throughout on nanocrystalline copper and a nanocrystalline Cu-Ta system, consolidated via equal channel angular extrusion, with properties rivaling that of nanocrystalline pure Ta. Moreover, modeling and simulation approaches as well as experimental results for grain growth, grain boundary processes, and deformation mechanisms in nanocrystalline copper are briefly reviewed and discussed. Integrating experiments and computational materials science for synthesizing bulk nanocrystalline materials can bring about the next generation of ultrahigh strength materials for defense and energy applications. C1 [Tschopp, M. A.; Murdoch, H. A.; Kecskes, L. J.; Darling, K. A.] US Army Res Lab, Aberdeen, MD 21005 USA. RP Tschopp, MA (reprint author), US Army Res Lab, Aberdeen, MD 21005 USA. EM mark.tschopp@gatech.edu OI Tschopp, Mark/0000-0001-8471-5035 NR 205 TC 19 Z9 19 U1 9 U2 84 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1047-4838 EI 1543-1851 J9 JOM-US JI JOM PD JUN PY 2014 VL 66 IS 6 BP 1000 EP 1019 DI 10.1007/s11837-014-0978-z PG 20 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing SC Materials Science; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing GA AI2ZM UT WOS:000336727700021 ER PT J AU Grujicic, M Yavari, R Snipes, JS Ramaswami, S Yen, CF Cheeseman, BA AF Grujicic, M. Yavari, R. Snipes, J. S. Ramaswami, S. Yen, C-F Cheeseman, B. A. TI Linear Friction Welding Process Model for Carpenter Custom 465 Precipitation-Hardened Martensitic Stainless Steel SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE LA English DT Article DE Carpenter Custom 465 precipitation-hardened martensitic stainless steel; linear friction welding; process modeling ID MECHANICAL-PROPERTIES; WELDED 45-STEEL; MICROSTRUCTURE; TI-6AL-4V; AUSTENITE; ALLOY AB An Arbitrary Lagrangian-Eulerian finite-element analysis is combined with thermo-mechanical material constitutive models for Carpenter Custom 465 precipitation-hardened martensitic stainless steel to develop a linear friction welding (LFW) process model for this material. The main effort was directed toward developing reliable material constitutive models for Carpenter Custom 465 and toward improving functional relations and parameterization of the workpiece/workpiece contact-interaction models. The LFW process model is then used to predict thermo-mechanical response of Carpenter Custom 465 during LFW. Specifically, temporal evolutions and spatial distribution of temperature within, and expulsion of the workpiece material from, the weld region are examined as a function of the basic LFW process parameters, i.e., (a) contact-pressure history, (b) reciprocation frequency, and (c) reciprocation amplitude. Examination of the results obtained clearly revealed the presence of three zones within the weld, i.e., (a) Contact-interface region, (b) Thermo-mechanically affected zone, and (c) heat-affected zone. While there are no publicly available reports related to Carpenter Custom 465 LFW behavior, to allow an experiment/computation comparison, these findings are consistent with the results of our ongoing companion experimental investigation. C1 [Grujicic, M.; Yavari, R.; Snipes, J. S.; Ramaswami, S.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. [Yen, C-F; Cheeseman, B. A.] Army Res Lab, Survivabil Mat Branch, Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM gmica@clemson.edu FU Army Research Office (ARO) [W911NF-11-1-0207] FX The initial portion of the work presented in the current manuscript was supported by the Army Research Office (ARO) through the grant W911NF-11-1-0207. The authors are indebted to Dr. Ralph A. Anthenien, Jr. of ARO for his continuing support and interest in the present work. The authors would also like to thank Dr. David Bowden for helpful discussions and encouragement. NR 38 TC 8 Z9 8 U1 0 U2 16 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9495 EI 1544-1024 J9 J MATER ENG PERFORM JI J. Mater. Eng. Perform. PD JUN PY 2014 VL 23 IS 6 BP 2182 EP 2198 DI 10.1007/s11665-014-0985-9 PG 17 WC Materials Science, Multidisciplinary SC Materials Science GA AH8MZ UT WOS:000336393300031 ER PT J AU Gaffney-Stomberg, E Cao, JJ Lin, GG Wulff, CR Murphy, NE Young, AJ McClung, JP Pasiakos, SM AF Gaffney-Stomberg, Erin Cao, Jay J. Lin, Gregory G. Wulff, Charles R. Murphy, Nancy E. Young, Andrew J. McClung, James P. Pasiakos, Stefan M. TI Dietary Protein Level and Source Differentially Affect Bone Metabolism, Strength, and Intestinal Calcium Transporter Expression during Ad Libitum and Food-Restricted Conditions in Male Rats SO JOURNAL OF NUTRITION LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; WEIGHT-LOSS; POSTMENOPAUSAL WOMEN; PARATHYROID-HORMONE; YOUNG-WOMEN; FEMALE RATS; ENERGY; MASS; SUPPLEMENTATION; REDUCTION AB High-protein (HP) diets may attenuate bone loss during energy restriction. The objective of the current study was to determine whether HP diets suppress bone turnover and improve bone quality in male rats during food restriction and whether dietary protein source affects this relation. Eighty 12-wk-old male Sprague Dawley rats were randomly assigned to consume 1 of 4 study diets under ad libitum (AL) control or restricted conditions [40% food restriction (FR)]: 1) 10% [normal-protein (NP)] milk protein; 2 32% (HP) milk protein; 10% (NP) soy protein; or 4) 32% (HP) soy protein. After 16 wk, markers of bone turnover, volumetric bone mineral density (vBMD), microarchitecture, strength, and expression of duodenal calcium channels were assessed. FR increased bone turnover and resulted in lower femoral trabecular bone volume (P < 0.05), higher cortical bone surface (P < 0.001), and reduced femur length (P < 0.01), bending moment (P < 0.05), and moment of inertia (P = 0.001) compared with AL. HP intake reduced bone turnover and tended to suppress parathyroid hormone (PTH) (P = 0.06) and increase trabecular vBMD (P < 0.05) compared with NP but did not affect bone strength. Compared with milk, soy suppressed PTH (P < 0.05) and increased cortical vBMD (P < 0.05) and calcium content of the femur (P < 0.01) but did not affect strength variables. During AL conditions, transient receptor potential cation channel, subfamily V, member 6 was higher for soy than milk (P < 0.05) and HP compared with NP (P < 0.05). These data demonstrate that both HP and soy diets suppress PTH, and HP attenuates bone turnover and increases vBMD regardless of FR, although these differences do not affect bone strength. The effects of HP and soy may be due in part to enhanced intestinal calcium transporter expression. C1 [Gaffney-Stomberg, Erin; Lin, Gregory G.; Wulff, Charles R.; Murphy, Nancy E.; Young, Andrew J.; McClung, James P.; Pasiakos, Stefan M.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. [Cao, Jay J.] USDA ARS, Grand Forks Human Nutr Res Ctr, Grand Forks, ND 58202 USA. RP Pasiakos, SM (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. EM stefan.pasiakos@us.army.mil RI Pasiakos, Stefan/E-6295-2014 OI Pasiakos, Stefan/0000-0002-5378-5820 FU U.S. Army Military Research and Material Command; Dairy Research Institute; USDA Agricultural Research Service program [5450-51000-046-00D] FX Supported in part by the U.S. Army Military Research and Material Command, the Dairy Research Institute, and appointments to the U.S. Army Research Institute of Environmental Medicine administered by the Oak Ridge Institute for Science and Education (to E G-S., G.G.L., and C R W) through an interagency agreement between the U.S. Department of Energy and the U.S. Army Medical Research and Materiel Command. J J.C. was supported by the USDA Agricultural Research Service program "Bone Metabolism in Obesity" Current Research Information System no. 5450-51000-046-00D The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Army or the Department of Defense. Any citations of commercial organizations and trade names in this report do not constitute an official Department of the Army endorsement of approval of the products or services of these organizations. NR 36 TC 4 Z9 6 U1 1 U2 8 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-3166 EI 1541-6100 J9 J NUTR JI J. Nutr. PD JUN PY 2014 VL 144 IS 6 BP 821 EP 829 DI 10.3945/jn.113.188532 PG 9 WC Nutrition & Dietetics SC Nutrition & Dietetics GA AH9LZ UT WOS:000336465200006 PM 24717364 ER PT J AU Sions, JM Velasco, TO Teyhen, DS Hicks, GE AF Sions, J. Megan Velasco, Teonette O. Teyhen, Deydre S. Hicks, Gregory E. TI Ultrasound Imaging: Intraexaminer and Interexaminer Reliability for Multifidus Muscle Thickness Assessment in Adults Aged 60 to 85 Years Versus Younger Adults SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE aging/geriatrics; lumbar spine; multifidus; ultrasonography ID LOW-BACK-PAIN; CROSS-SECTIONAL AREA; INTERRATER RELIABILITY; TRANSVERSUS ABDOMINIS; OLDER-ADULTS; CONTRACTION; REPRODUCIBILITY; INTRARATER; EXTENSION; MOBILITY AB STUDY DESIGN: Intraexaminer and interexaminer, within- and between-day reliability study. OBJECTIVES: To compare the intraexaminer and interexaminer procedural reliability of ultrasound imaging (USI) thickness measurements of the lumbar multifidus muscle at rest and during a contralateral lower-limb lift (CLL) between older (60-85 years of age) and younger (18:40 years of age) adults. BACKGROUND: Among younger adults, USI has been shown to be reliable and valid for assessing multifidus thickness. Older adults present with age-related changes that may impact assessment. To our knowledge, no USI studies have focused on establishing reliability for multifidus thickness assessments in older adults. METHODS: Two examiners performed assessments of lumbar multifidus thickness at rest and during a CLL in 30 older and 31 younger adults. Intraclass correlation coefficient (ICC) with 95% confidence interval, standard error of measurement, 95% minimal detectable change for resting and during the CLL, and percent thickness change were calculated. RESULTS: Within-day interexaminer procedural reliability for multifidus thickness measurements was similar among younger (ICC = 0.90-0.92) and older adults (ICC = 0.86-0.90), as was between-day intraexaminer and interexaminer reliability (younger adults, ICC = 0.84-0.94; older adults, ICC = 0.860.93). Throughout, estimates of percent thickness change were inconsistent (ICC = 0.31-0.86), and standard errors of measurement and minimal detectable changes were larger for older adults. CONCLUSION: Ultrasound imaging reliability for measurements of multifidus thickness at rest and during a CLL among older adults is consistent with previously published findings for younger adults. Among older adults, it may be preferable to have a single examiner conduct USI assessments. C1 [Sions, J. Megan; Velasco, Teonette O.; Hicks, Gregory E.] Univ Delaware, Dept Phys Therapy, Newark, DE 19713 USA. [Teyhen, Deydre S.] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA. RP Sions, JM (reprint author), Univ Delaware, 540 South Coll Ave,Suite 144A, Newark, DE 19713 USA. EM megsions@udel.edu FU Foundation for Physical Therapy PODS I/II; University of Delaware Office of Graduate Studies [R21 HD057274, 1R01AG041202-01]; NICHD [R21 HD057274, 1R01AG041202-01] FX The work of Dr Sims is supported in part by the Foundation for Physical Therapy PODS I/II, the University of Delaware Office of Graduate Studies, R21 HD057274 (IVICHD), and 1R01AG041202-01 (NIA). The work of Dr Velasco and Dr Hicks is supported in part by R21 HD057274 (NICHD) and 1R01AG041202-01 (NIA). NR 34 TC 5 Z9 5 U1 1 U2 3 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD JUN PY 2014 VL 44 IS 6 BP 425 EP 434 DI 10.2519/jospt.2014.4584 PG 10 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA AI2RL UT WOS:000336705700005 PM 24766356 ER PT J AU Ray, DM Roediger, PA Neyer, BT AF Ray, Douglas M. Roediger, Paul A. Neyer, Barry T. TI Commentary: Three-phase optimal design for sensitivity experiments SO JOURNAL OF STATISTICAL PLANNING AND INFERENCE LA English DT Editorial Material ID QUANTAL RESPONSE CURVES; SEQUENTIAL ESTIMATION C1 [Ray, Douglas M.] US Army ARDEC, Picatinny Arsenal, NJ 07806 USA. [Roediger, Paul A.] UTRS Inc, Picatinny Arsenal, NJ 07806 USA. [Neyer, Barry T.] Excelitas Technol Corp, Miamisburg, OH 45342 USA. RP Ray, DM (reprint author), US Army ARDEC, Picatinny Arsenal, NJ 07806 USA. EM douglas.m.ray.civ@mail.mil; paul.a.roediger.ctr@mail.mil; Barry.Neyer@excelitas.com NR 16 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3758 EI 1873-1171 J9 J STAT PLAN INFER JI J. Stat. Plan. Infer. PD JUN PY 2014 VL 149 BP 20 EP 25 DI 10.1016/j.jspi.2013.12.010 PG 6 WC Statistics & Probability SC Mathematics GA AI2RM UT WOS:000336705800003 ER PT J AU Theeler, BJ Ellezam, B Sadighi, ZS Mehta, V Tran, MD Adesina, AM Bruner, JM Puduvalli, VK AF Theeler, Brett J. Ellezam, Benjamin Sadighi, Zsila S. Mehta, Vidya Tran, M. Diep Adesina, Adekunle M. Bruner, Janet M. Puduvalli, Vinay K. TI Adult pilocytic astrocytomas: clinical features and molecular analysis SO NEURO-ONCOLOGY LA English DT Article DE BRAF mutation; low-grade astrocytoma; pilocytic astrocytoma ID BRAF FUSION GENE; DIFFUSE GLIOMAS; LEPTOMENINGEAL DISSEMINATION; MUTATION; FREQUENT; PATHWAY; DUPLICATION; ACTIVATION; PREDICTS; CHILDREN AB Adult pilocytic astrocytomas (PAs) are rare and have an aggressive clinical course compared with pediatric patients. Constitutive Ras/RAF/MAPK signaling appears to be an important oncogenic event in sporadic PA. We evaluated clinical data and molecular profiles of adult PAs at our institution. We identified 127 adult PAs in our institutional database. Cases with available tissue were tested for BRAF-KIAA1549 fusion/duplication (B-K fusion) by fluorescence in situ hybridization and submitted for mutation profiling using the Sequenom mutation profiling panel. Subgroup analyses were performed based on clinical and molecular data. The majority of adult PAs are supratentorial. Twenty-two percent of cases had an initial pathologic diagnosis discordant with the diagnosis made at our institution. Recurrence was seen in 42% of cases, and 13% of patients died during follow-up. Adjuvant radiotherapy following surgical resection was associated with a statistically significant decrease in progression-free survival (P = .004). B-K fusion was identified in 20% (9 of 45) of patients but was not associated with outcome. No BRAF V600E mutations (0 of 40 tested) were found. This was the largest single institution series of adult PA. A significant proportion of adult PAs follow an aggressive clinical course. Our results support a period of observation following biopsy or surgical resection. B-K fusion in adult PA does not influence outcome, and BRAF V600E mutation appears to be a very rare event. Further study of tumor biology and optimal treatment is needed, given a more aggressive clinical behavior. C1 [Theeler, Brett J.] Walter Reed Natl Mil Med Ctr, Dept Neurol, Bethesda, MD USA. [Theeler, Brett J.] Walter Reed Natl Mil Med Ctr, John P Murtha Canc Ctr, Bethesda, MD USA. [Ellezam, Benjamin] Univ Montreal, Dept Pathol, CHU St Justine, Montreal, PQ H3C 3J7, Canada. [Sadighi, Zsila S.] St Jude Childrens Res Hosp, Memphis, TN 38105 USA. [Mehta, Vidya; Tran, M. Diep; Adesina, Adekunle M.] Texas Childrens Hosp, Dept Pathol, Houston, TX 77030 USA. [Mehta, Vidya; Tran, M. Diep; Adesina, Adekunle M.] Baylor Coll Med, Houston, TX 77030 USA. [Bruner, Janet M.] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA. [Puduvalli, Vinay K.] Ohio State Univ, Dept Neurosurg, Arthur G James Canc Hosp, Columbus, OH 43210 USA. RP Theeler, BJ (reprint author), US Army, Med Corps, Dept Neurol, 8901 Wisconsin Ave,Bldg 19,6th Floor, Bethesda, MD 20889 USA. EM btheeler@hotmail.com RI Puduvalli, Vinay/A-2411-2016 FU Ferenc and Phyllis Gyorkey Endowed Chair in Pathology of The University of Texas MD Anderson Cancer Center FX Supported in part by the Ferenc and Phyllis Gyorkey Endowed Chair in Pathology of The University of Texas MD Anderson Cancer Center (JMB). NR 39 TC 7 Z9 7 U1 1 U2 4 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1522-8517 EI 1523-5866 J9 NEURO-ONCOLOGY JI Neuro-Oncology PD JUN PY 2014 VL 16 IS 6 BP 841 EP 847 DI 10.1093/neuonc/not246 PG 7 WC Oncology; Clinical Neurology SC Oncology; Neurosciences & Neurology GA AH9WO UT WOS:000336496000015 PM 24470550 ER PT J AU Ressler, KJ Schoomaker, EB AF Ressler, Kerry J. Schoomaker, Eric B. TI Army STARRS: A Framingham-Like Study of Psychological Health Risk Factors in Soldiers SO PSYCHIATRY-INTERPERSONAL AND BIOLOGICAL PROCESSES LA English DT Editorial Material ID MENTAL-DISORDERS; US MILITARY; RESILIENCE; SUICIDE; DESIGN C1 [Ressler, Kerry J.] Emory Univ, Howard Hughes Med Inst, Atlanta, GA 30329 USA. [Schoomaker, Eric B.] US Army, Adelphi, MD 20783 USA. [Schoomaker, Eric B.] Uniformed Serv Univ Hlth Sci, US Army Med Command, Bethesda, MD 20814 USA. RP Ressler, KJ (reprint author), Emory Univ, Yerkes Res Ctr, 954 Gatewood Rd NE, Atlanta, GA 30329 USA. EM kressle@emory.edu FU Howard Hughes Medical Institute; NIMH NIH HHS [MH096764, MH071537, MH094757] NR 22 TC 1 Z9 1 U1 2 U2 7 PU GUILFORD PUBLICATIONS INC PI NEW YORK PA 72 SPRING STREET, NEW YORK, NY 10012 USA SN 0033-2747 J9 PSYCHIATRY JI Psychiatry-Interpers. Biol. Process. PD SUM PY 2014 VL 77 IS 2 BP 120 EP 129 PG 10 WC Psychiatry SC Psychiatry GA AI1VD UT WOS:000336642400002 PM 24865196 ER PT J AU Tokish, JM AF Tokish, John M. TI Acquired and Adaptive Changes in the Throwing Athlete: Implications on the Disabled Throwing Shoulder SO SPORTS MEDICINE AND ARTHROSCOPY REVIEW LA English DT Review DE throwing shoulder; humeral torsion; GIRD; internal impingement; TAM; throwing adaptations ID PROFESSIONAL BASEBALL PITCHERS; INTERNAL-ROTATION DEFICIT; GLENOHUMERAL RANGE; HUMERAL RETROVERSION; ECCENTRIC EXERCISE; MOTION DEFICITS; PASSIVE RANGE; KINETIC CHAIN; PITCHING ARM; PLAYERS AB The throwing shoulder continues to be one of the most actively studied and poorly understood aspects of sports medicine. The act of throwing itself transfers tremendous power throughout the kinetic chain, resulting in forces experienced in the shoulder that can exceed its physiologic limits. These forces over time lead to many adaptive changes in the bone, capsule, and muscular structures of the shoulder girdle. An understanding of these acquired changes is critical to differentiate between normal or protective adaptation and pathologic change. The purposes of this article were to elucidate the adaptive and acquired changes, which commonly develop in the throwing shoulder, to explain how these changes contribute in both protective and pathologic roles, and to apply these principles into a deeper understanding of the care of the disabled throwing shoulder. C1 [Tokish, John M.] Tripler Army Med Ctr, Orthopaed Surg Residency Program, Honolulu, HI 96859 USA. RP Tokish, JM (reprint author), Tripler Army Med Ctr, MCHK DSO Orthopaed Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 51 TC 1 Z9 1 U1 1 U2 10 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1062-8592 EI 1538-1951 J9 SPORTS MED ARTHROSC JI Sports Med. Arthrosc. Rev. PD JUN PY 2014 VL 22 IS 2 BP 88 EP 93 DI 10.1097/JSA.0000000000000015 PG 6 WC Sport Sciences SC Sport Sciences GA AH9ZS UT WOS:000336506000004 PM 24787722 ER PT J AU Naluyima, P Eller, MA Laeyendecker, O Quinn, TC Serwadda, D Sewankambo, NK Gray, RH Michael, NL Wabwire-Mangen, F Robb, ML Sandberg, JK AF Naluyima, Prossy Eller, Michael A. Laeyendecker, Oliver Quinn, Thomas C. Serwadda, David Sewankambo, Nelson K. Gray, Ronald H. Michael, Nelson L. Wabwire-Mangen, Fred Robb, Merlin L. Sandberg, Johan K. TI Impaired natural killer cell responses are associated with loss of the highly activated NKG2AR CD57 R CD56 dim subset in HIV-1 subtype D infection in Uganda SO AIDS LA English DT Article DE AIDS; CD57; HIV-1; immune activation; natural killer cells; NKG2A; subtype D ID VIRUS TYPE-1 INFECTION; KIR3DL1(+) NK CELLS; DENDRITIC CELLS; INNATE IMMUNITY; RAKAI DISTRICT; T-CELLS; HLA-B; EXPRESSION; DIVERSITY; PATTERNS AB Objective:Of the predominant HIV-1 subtypes in Uganda, subtype D infection confers a worse prognosis. HIV-1 infection causes perturbations to natural killer (NK) cells, and yet these cells can exert immune pressure on the virus and influence clinical outcome. Here, we studied NK cell activation and function in Ugandans with chronic untreated HIV-1 subtype D infection in comparison to uninfected community matched controls.Methods:Cryopreserved peripheral blood mononuclear cells (PBMCs) from 42 HIV-infected individuals and 28 HIV-negative controls were analysed using eight-colour flow cytometry. NK cell surface expression of CD16, CD56, CD57, HLA-DR and NKG2A were used to investigate activation, maturation and differentiation status. NK cell function was evaluated by measuring interferon-gamma (IFN) production in response to K562 cells, or interleukin (IL)-12 and IL-18.Results:CD56(dim) NK cells from HIV-infected individuals produced less IFN in response to IL-12 and IL-18 than did CD56(dim) NK cells from uninfected controls. Infected individuals had lower levels of CD56(dim) NK cells coexpressing the differentiation markers NKG2A and CD57 than controls. In addition, their NKG2A(+)CD57(+) CD56(dim) NK cells displayed elevated activation levels as assessed by HLA-DR expression. Cytokine-induced IFN production correlated directly with coexpression of CD57 and NKG2A on CD56(dim) NK cells.Conclusion:HIV-1 subtype D infection is associated with impaired NK cell responsiveness to cytokines, decline of the NKG2A(+)CD57(+) CD56(dim) NK cell subset, as well as elevated activation in this subset. These alterations within the NK cell compartment may contribute to immunopathogenesis of HIV-1 subtype D infection in Ugandans. C1 [Naluyima, Prossy; Wabwire-Mangen, Fred] Makerere Univ Walter Reed Project, Kampala, Uganda. [Naluyima, Prossy; Sandberg, Johan K.] Karolinska Univ Hosp Huddinge, Karolinska Inst, Ctr Infect Med, Dept Med, S-14186 Stockholm, Sweden. [Eller, Michael A.; Michael, Nelson L.; Robb, Merlin L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Eller, Michael A.; Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Laeyendecker, Oliver; Quinn, Thomas C.] NIAID, Div Intramural Res, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA. [Laeyendecker, Oliver; Quinn, Thomas C.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Serwadda, David; Wabwire-Mangen, Fred] Makerere Univ, Coll Hlth Sci, Sch Publ Hlth, Kampala, Uganda. [Serwadda, David; Sewankambo, Nelson K.] Uganda Virus Res Inst, Rakai Hlth Sci Program, Entebbe, Uganda. [Sewankambo, Nelson K.] Makerere Univ, Coll Hlth Sci, Fac Med, Kampala, Uganda. [Gray, Ronald H.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA. RP Sandberg, JK (reprint author), Karolinska Univ Hosp Huddinge, Karolinska Inst, Ctr Infect Med, Dept Med, F59, S-14186 Stockholm, Sweden. EM johan.sandberg@ki.se FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense; National Institute of Allergy and Infectious Diseases (NIAID) [R01 AI34826, R01 AI34265]; National Institute of Child and Health Development [5P30HD06826]; Fogarty Foundation [5D43TW00010]; Swedish Research Council; Swedish Cancer Society; Stockholm County Council; Karolinska Institutet; Division of Intramural Research, NIAID, NIH FX Primary support was provided by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense. Data collection was supported, in part, by grants R01 AI34826 and R01 AI34265 from the National Institute of Allergy and Infectious Diseases (NIAID); grant 5P30HD06826 from the National Institute of Child and Health Development; grant 5D43TW00010 from the Fogarty Foundation. Additional support was provided by the Swedish Research Council, the Swedish Cancer Society, the Stockholm County Council, Karolinska Institutet and the Division of Intramural Research, NIAID, NIH. NR 39 TC 4 Z9 4 U1 0 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0269-9370 EI 1473-5571 J9 AIDS JI Aids PD JUN 1 PY 2014 VL 28 IS 9 BP 1273 EP 1278 DI 10.1097/QAD.0000000000000286 PG 6 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AH2SX UT WOS:000335972500004 PM 24959961 ER PT J AU Islam, D Ruamsap, N Khantapura, P Aksomboon, A Srijan, A Wongstitwilairoong, B Bodhidatta, L Gettayacamin, M Venkatesan, MM Mason, CJ AF Islam, Dilara Ruamsap, Nattaya Khantapura, Patchariya Aksomboon, Ajchara Srijan, Apichai Wongstitwilairoong, Boonchai Bodhidatta, Ladaporn Gettayacamin, Montip Venkatesan, Malabi M. Mason, Carl J. TI Evaluation of an intragastric challenge model for Shigella dysenteriae 1 in rhesus monkeys (Macaca mulatta) for the pre-clinical assessment of Shigella vaccine formulations SO APMIS LA English DT Article DE Shigellosis; rhesus monkey (Macaca mulatta); challenge model ID FLEXNERI INFECTION; ANIMAL-MODEL; ESCHERICHIA-COLI; RECTAL MUCOSA; GUINEA-PIG; DISEASE; PATHOGENESIS; ANTIGEN; DIARRHEA; CELLS AB Shigellosis is a worldwide disease, characterized by abdominal pain, fever, vomiting, and the passage of blood- and mucus-streaked stools. Rhesus monkeys and other primates are the only animals that are naturally susceptible to shigellosis. A suitable animal model is required for the pre-clinical evaluation of vaccines candidates. In this study, the minimal dose of Shigella dysenteriae1 1617 strain required to produce dysentery in four of five (80% attack rate) monkeys using an escalating dose range for three groups [2x10(8), 2x10(9) and 2x10(10) colony forming unit (CFU)] was determined. In addition, the monkeys were re-infected. The identified optimal challenge dose was 2x10(9) CFU; this dose elicited 60% protection in monkeys when they were re-challenged with a one log higher dose (2x10(10) CFU). The challenge dose, 2x10(10) CFU, produced severe dysentery in all monkeys, with one monkey dying within 24h, elicited 100% protection when re-challenged with the same dose. All monkeys exhibited immune responses. This study concludes that the rhesus monkey model closely mimics the disease and immune response seen in humans and is a suitable animal model for the pre-clinical evaluation of Shigella vaccine candidates. Prior infection with the 1617 strain can protect monkeys against subsequent re-challenges with homologous strains. C1 [Islam, Dilara; Ruamsap, Nattaya; Khantapura, Patchariya; Aksomboon, Ajchara; Srijan, Apichai; Wongstitwilairoong, Boonchai; Bodhidatta, Ladaporn; Mason, Carl J.] AFRIMS, Dept Enter Dis, Bangkok 10400, Thailand. [Gettayacamin, Montip] AFRIMS, Dept Vet Med, Bangkok 10400, Thailand. [Venkatesan, Malabi M.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Islam, D (reprint author), AFRIMS, Dept Enter Dis, 315-6 Rachawithi Rd, Bangkok 10400, Thailand. EM islamd@afrims.org OI MASON, CARL/0000-0002-3676-2811 FU National Institute of Allergy and Infectious Diseases (NIAID) under IAA [Y1-AI-4906-03]; Department of Defense, US Army Medical and Materiel Development Command (USAMRMC) FX The authors thank the laboratory staff in the Department of Enteric Diseases and in the Department of Veterinary Medicine, AFRIMS, for their contribution to this study. This work was supported by the National Institute of Allergy and Infectious Diseases (NIAID), under IAA # Y1-AI-4906-03, and by the Department of Defense, US Army Medical and Materiel Development Command (USAMRMC). NR 55 TC 3 Z9 3 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0903-4641 EI 1600-0463 J9 APMIS JI APMIS PD JUN PY 2014 VL 122 IS 6 BP 463 EP 475 DI 10.1111/apm.12168 PG 13 WC Immunology; Microbiology; Pathology SC Immunology; Microbiology; Pathology GA AH9FN UT WOS:000336447200001 PM 24028276 ER PT J AU Filan, E Abbas, M AF Filan, Eamon Abbas, Mazen TI Abdominal Pain, Fever, and Infection Secondary to an Unusual Source in a Previously Healthy Child SO CLINICAL PEDIATRICS LA English DT Editorial Material ID PERITONITIS; APPENDICITIS C1 [Filan, Eamon; Abbas, Mazen] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Filan, E (reprint author), Tripler Army Med Ctr, Dept Pediat, MCHK PE, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM eamon.l.filan.mil@mail.mil NR 10 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0009-9228 EI 1938-2707 J9 CLIN PEDIATR JI Clin. Pediatr. PD JUN PY 2014 VL 53 IS 6 BP 607 EP 609 DI 10.1177/0009922814526987 PG 3 WC Pediatrics SC Pediatrics GA AG9TP UT WOS:000335763000017 PM 24634431 ER PT J AU Torrealday, S AF Torrealday, Saioa TI Is the fertility treatment itself a risk factor for early pregnancy loss? SO CURRENT OPINION IN OBSTETRICS & GYNECOLOGY LA English DT Review DE assisted reproductive technology; early pregnancy loss; fertility treatment; spontaneous abortion ID ASSISTED REPRODUCTIVE TECHNOLOGY; INTRAUTERINE INSEMINATION; CLOMIPHENE CITRATE; SPONTANEOUS-ABORTION; CHROMOSOME-ABNORMALITIES; OVARIAN HYPERSTIMULATION; OVULATION INDUCTION; INFERTILE WOMEN; MISCARRIAGE; CONCEPTION AB Purpose of reviewWith the recent advancements in reproductive medicine, many infertile couples now have the opportunity to conceive their own biological children. Although some medication protocols, such as clomiphene citrate, have been utilized for decades, other treatment modalities have evolved over the recent years. It therefore becomes imperative to assess the outcomes of these modalities and be critical regarding their safety. Pregnancy loss is one outcome that can affect many couples who conceive both spontaneously and with assistance via fertility treatment. In this review, several of the most commonly used fertility treatments will be discussed and the impact, if any, they may have in early pregnancy loss will be addressed.Recent findingsCurrent data do not support that notion that infertility treatments or assisted reproductive techniques contribute to early pregnancy loss. However, more studies are needed to eliminate the confounding variables that make data interpretation difficult to generalize to the infertile population.SummaryAn early pregnancy loss can cause emotional distress and grief, particularly for couples already dealing with an infertility diagnosis. Therefore, knowledge regarding the relationship between infertility and early pregnancy loss is vital in order to properly counsel the couple prior to starting treatment. C1 Womack Army Med Ctr, Dept Obstet & Gynecol, Ft Bragg, NC 28301 USA. RP Torrealday, S (reprint author), Womack Army Med Ctr, Dept Obstet & Gynecol, Ft Bragg, NC 28301 USA. EM saioa.torrealday.mil@mail.mil NR 58 TC 1 Z9 1 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1040-872X EI 1473-656X J9 CURR OPIN OBSTET GYN JI Curr. Opin. Obstet. Gynecol. PD JUN PY 2014 VL 26 IS 3 BP 174 EP 180 DI 10.1097/GCO.0000000000000064 PG 7 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA AH1PF UT WOS:000335892600008 PM 24752000 ER PT J AU Stanley, JK Coleman, JG Brasfield, SM Bednar, AJ Ang, CY AF Stanley, Jacob K. Coleman, Jessica G. Brasfield, Sandra M. Bednar, Anthony J. Ang, Choo Y. TI ENVIRONMENTAL ASSESSMENT OF DEPLETED URANIUM USED IN MILITARY ARMOR-PIERCING ROUNDS IN TERRESTRIAL SYSTEMS SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Depleted uranium; Terrestrial invertebrate toxicology; Earthworm; Behavioral toxicology; Isopod ID ECOLOGICAL RISK-ASSESSMENT; EISENIA-FOETIDA; SOIL; EARTHWORMS; TOXICITY; CONTAMINATION; BIOACCUMULATION; REMEDIATION; EFFICIENCY; KOSOVO AB Depleted uranium (DU) from the military testing and use of armor-piercing kinetic energy penetrators has been shown to accumulate in soils; however, little is known about the toxicity of DU geochemical species created through corrosion or weathering. The purpose of the present study was to assess the toxic effects and bioaccumulation potential of field-collected DU oxides to the model terrestrial invertebrates Eisenia fetida (earthworm) and Porcellio scaber (isopod). Earthworm studies were acute (72 h) dermal exposures or 28-d spiked soil exposures that used noncontaminated field-collected soils from the US Army's Yuma and Aberdeen Proving Grounds. Endpoints assessed in earthworm testing included bioaccumulation, growth, reproduction, behavior (soil avoidance), and cellular stress (neutral red uptake in coelomocytes). Isopod testing used spiked food, and endpoints assessed included bioaccumulation, survival, and feeding behavior. Concentration-dependent bioaccumulation of DU in earthworms was observed with a maximum bioaccumulation factor of 0.35; however, no significant reductions in survival or impacts to cellular stress were observed. Reproduction lowest-observed-effect concentrations (LOEC) of 158 mg/kg and 96 mg/kg were observed in Yuma Proving Ground and a Mississippi reference soil (Karnac Ferry), respectively. Earthworm avoidance of contaminated soils was not observed in 48-h soil avoidance studies; however, isopods were shown to avoid food spiked with 12.7% by weight DU oxides through digital tracking studies. Environ Toxicol Chem 2014;33:1308-1314. (c) 2014 SETAC C1 [Stanley, Jacob K.; Coleman, Jessica G.; Brasfield, Sandra M.; Bednar, Anthony J.] US Army, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Ang, Choo Y.] Badger Tech Serv, Vicksburg, MS USA. RP Stanley, JK (reprint author), US Army, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. EM jacob.k.stanley@us.army.mil NR 33 TC 1 Z9 1 U1 2 U2 32 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD JUN PY 2014 VL 33 IS 6 BP 1308 EP 1314 DI 10.1002/etc.2551 PG 7 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA AH2FM UT WOS:000335936900001 PM 24549573 ER PT J AU Richmond, MC Serkowski, JA Ebner, LL Sick, M Brown, RS Carlson, TJ AF Richmond, Marshall C. Serkowski, John A. Ebner, Laurie L. Sick, Mirjam Brown, Richard S. Carlson, Thomas J. TI Quantifying barotrauma risk to juvenile fish during hydro-turbine passage. SO FISHERIES RESEARCH LA English DT Article DE Turbine; Hydropower; Fish passage; Salmon; Barotrauma; Computational fluid dynamics (CFD) ID SURVIVAL AB We introduce a method for hydro turbine biological performance assessment (BioPA) to bridge the gap between field and laboratory studies on fish injury and turbine engineering design. Using this method, a suite of biological performance indicators is computed based on simulated data from a computational fluid dynamics (CFD) model of a proposed hydro turbine design. Each performance indicator is a measure of the probability of exposure to a certain dose of an injury mechanism. If the relationship between the dose of an injury mechanism (stressor) and frequency of injury (dose-response) is known from laboratory or field studies, the likelihood of fish injury for a turbine design can be computed from the performance indicator. By comparing the values of the indicators from various turbine designs, engineers and biologists can identify the more-promising designs and operating conditions to minimize hydraulic conditions hazardous to passing fish. In this paper, the BioPA method is applied to estimate barotrauma induced mortal injury rates for Chinook salmon exposed to rapid pressure changes in Kaplan-type hydro turbines. Following the description of the general method, application of the BioPA to estimate the probability of mortal injury from exposure to rapid decompression is illustrated using a Kaplan hydro turbine at the John Day Dam on the Columbia River in the Pacific Northwest region of the USA. The estimated rates of mortal injury increased from 0.3% to 1.7% as discharge through the turbine increased from 334 to 564 m(3)/s for fish assumed to be acclimated to a depth of 5 m. The majority of pressure nadirs occurred immediately below the runner blades, with the lowest values in the gap at the blade tips and just below the leading edge of the blades. Such information can help engineers focus on problem areas when designing new turbine runners to be more fish-friendly than existing units. (C) 2014 Battelle Memorial Institute and Andritz Hydro Limited. Published by Elsevier B.V. All rights reserved. C1 [Richmond, Marshall C.; Serkowski, John A.] Pacific NW Natl Lab, Earth Syst Sci Div, Hydrol Grp, Richland, WA 99352 USA. [Ebner, Laurie L.] US Army Corps Engn, Portland, OR USA. [Sick, Mirjam] Andritz Hydro, Zurich, Switzerland. [Brown, Richard S.] Pacific NW Natl Lab, Earth Syst Sci Div, Ecol Grp, Richland, WA 99352 USA. [Carlson, Thomas J.] Pacific NW Natl Lab, Coastal Sci Div, Sequim, WA USA. RP Richmond, MC (reprint author), POB 999, Richland, WA 99352 USA. EM marshall.richmond@pnnl.gov RI Richmond, Marshall/D-3915-2013 OI Richmond, Marshall/0000-0003-0111-1485 FU US Department of Energy; Energy Efficiency and Renewable Energy; Wind and Water Power Program; Battelle Memorial Institute [DE-AC06-76RLO 1830] FX This research was supported by the US Department of Energy, Energy Efficiency and Renewable Energy, Wind and Water Power Program.; We thank Kenneth Ham of PNNL for assisting with the hydroacoustics data for estimating vertical fish distribution.; The US Army Corps of Engineers Turbine Survival Program provided the CFD model results for the John Day Dam turbine.; Pacific Northwest National Laboratory (PNNL) is operated for the US Department of Energy by Battelle Memorial Institute under Contract No. DE-AC06-76RLO 1830. NR 42 TC 6 Z9 6 U1 5 U2 34 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-7836 EI 1872-6763 J9 FISH RES JI Fish Res. PD JUN PY 2014 VL 154 BP 152 EP 164 DI 10.1016/j.flshres.2014.01.007 PG 13 WC Fisheries SC Fisheries GA AH4RZ UT WOS:000336117000016 ER PT J AU Cook, KV Brown, RS Deng, ZD Klett, RS Li, HD Seaburg, AG Eppard, MB AF Cook, Katrina V. Brown, Richard S. Deng, Z. Daniel Klett, Ryan S. Li, Huidong Seaburg, Adam G. Eppard, M. Brad TI A comparison of implantation methods for large PIT tags or injectable acoustic transmitters in juvenile Chinook salmon SO FISHERIES RESEARCH LA English DT Article DE Telemetry; Injection; Salmonid; Surgery; Tagging ID INTEGRATED TRANSPONDER TAGS; COASTAL CUTTHROAT TROUT; ATLANTIC SALMON; SWIMMING PERFORMANCE; SURGICAL IMPLANTATION; COLUMBIA RIVER; MAXIMUM TAG; SURVIVAL; GROWTH; RETENTION AB The miniaturization of acoustic transmitters may allow greater flexibility in terms of the size and species of fish available to tag. New downsized injectable acoustic tags similar in shape to passive integrated transponder tags can be rapidly injected rather than surgically implanted through a sutured incision. Before wide-scale field use of these injectable transmitters, standard protocols to ensure the most effective and least damaging methods of implantation must be developed. Three implantation methods were tested in various sizes of juvenile Chinook salmon (Oncorhynchus tschawytscha). Methods included a needle bevel-down injection, a needle bevel-up injection with a 90 degrees rotation, and tag implantation through an unsutured incision. Tagged fish were compared to untagged control groups. Weight and wound area were measured at tagging and every week for 3 weeks; holding tanks were checked daily for mortalities and tag losses. No significant differences among treatments were found in tag loss, or survival, but wound area was significantly reduced among fish tagged via an incision and growth was slightly reduced in bevel down fish. Although there were no significant differences, the bevel-up injection trended toward having the worst results in terms of tag loss and wound area and had high mortality. Implantation through an incision resulted in the lowest tag loss but the highest mortality. Fish from the bevel-down treatment group had the least mortality and smaller wound areas than the bevel-up treatment group but also showed reduced growth. Cumulatively, the data suggest that the unsutured incision and bevel-down injection methods were the most effective; the drawbacks of both methods are described in detail. (C) 2014 Elsevier B.V. All rights reserved. C1 [Cook, Katrina V.; Brown, Richard S.; Klett, Ryan S.] Pacific NW Natl Lab, Ecol Grp, Richland, WA 99352 USA. [Deng, Z. Daniel; Li, Huidong] Pacific NW Natl Lab, Hydrol Grp, Richland, WA 99352 USA. [Seaburg, Adam G.] Univ Washington, Sch Aquat & Fishery Sci, Columbia Basin Res, Seattle, WA 98101 USA. [Eppard, M. Brad] US Army Corps Engineers, Portland, OR 97208 USA. RP Brown, RS (reprint author), Pacific NW Natl Lab, Ecol Grp, POB 999, Richland, WA 99352 USA. EM rich.brown@pnnl.gov RI Deng, Daniel/A-9536-2011 OI Deng, Daniel/0000-0002-8300-8766 NR 56 TC 9 Z9 9 U1 3 U2 39 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-7836 EI 1872-6763 J9 FISH RES JI Fish Res. PD JUN PY 2014 VL 154 BP 213 EP 223 DI 10.1016/j.fishres.2013.11.006 PG 11 WC Fisheries SC Fisheries GA AH4RZ UT WOS:000336117000022 ER PT J AU Peng, XQ Perkins, MW Simons, J Witriol, AM Rodriguez, AM Benjamin, BM Devorak, J Sciuto, AM AF Peng, Xinqi Perkins, Michael W. Simons, Jannitt Witriol, Alicia M. Rodriguez, Ashley M. Benjamin, Brittany M. Devorak, Jennifer Sciuto, Alfred M. TI Acute pulmonary toxicity following inhalation exposure to aerosolized VX in anesthetized rats SO INHALATION TOXICOLOGY LA English DT Article DE Chemical warfare nerve agents; cholinesterases; inhalation exposure; respiratory toxicity; VX ID NERVE AGENT VX; GUINEA-PIGS; RESPIRATORY DYNAMICS; WARFARE AGENTS; SOMAN; PROTECTION; EXERCISE; ACETYLCHOLINESTERASE; TERRORISM; SARIN AB This study evaluated acute toxicity and pulmonary injury in rats at 3, 6 and 24 h after an inhalation exposure to aerosolized O-ethyl S-[2-(diisopropylamino) ethyl] methylphosphonothioate (VX). Anesthetized male Sprague-Dawley rats (250-300 g) were incubated with a glass endotracheal tube and exposed to saline or VX (171, 343 and 514 mg x min/m(3) or 0.2, 0.5 and 0.8 LCt(50), respectively) for 10 min. VX was delivered by a small animal ventilator at a volume of 2.5 ml x 70 breaths/minute. All VX-exposed animals experienced a significant loss in percentage body weight at 3, 6, and 24 h post-exposure. In comparison to controls, animals exposed to 514 mg x min/m(3) of VX had significant increases in bronchoalveolar lavage (BAL) protein concentrations at 6 and 24 h post-exposure. Blood acetylcholinesterase (AChE) activity was inhibited dose dependently at each of the times points for all VX-exposed groups. AChE activity in lung homogenates was significantly inhibited in all VX-exposed groups at each time point. All VX-exposed animals assessed at 20 min and 3, 6 and 24 h post-exposure showed increases in lung resistance, which was prominent at 20 min and 3 h post-exposure. Histopathologic evaluation of lung tissue of the 514 mg x min/m(3) VX-exposed animals at 3, 6 and 24 h indicated morphological changes, including perivascular inflammation, alveolar exudate and histiocytosis, alveolar septal inflammation and edema, alveolar epithelial necrosis, and bronchiolar inflammatory infiltrates, in comparison to controls. These results suggest that aerosolization of the highly toxic, persistent chemical warfare nerve agent VX results in acute pulmonary toxicity and lung injury in rats. C1 [Peng, Xinqi; Perkins, Michael W.; Simons, Jannitt; Witriol, Alicia M.; Rodriguez, Ashley M.; Benjamin, Brittany M.; Devorak, Jennifer; Sciuto, Alfred M.] US Army Med Res Inst Chem Def, Analyt Toxicol Div, Med Toxicol Branch, Aberdeen Proving Ground, MD 21010 USA. RP Sciuto, AM (reprint author), US Army Med Res Inst Chem Def, Analyt Toxicol Div, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM alfred.mario.sciuto@us.army.mil FU Defense Threat Reduction Agency [RESP.01.10.RC.007] FX The author has no declaration of interest. The views expressed in this article are those of the author(s) and do not reflect the official policy of the Department of Army, Department of Defense, or the U.S. Government. The project described was supported by Defense Threat Reduction Agency (RESP.01.10.RC.007). NR 35 TC 1 Z9 1 U1 0 U2 17 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0895-8378 EI 1091-7691 J9 INHAL TOXICOL JI Inhal. Toxicol. PD JUN PY 2014 VL 26 IS 7 BP 371 EP 379 DI 10.3109/08958378.2014.899410 PG 9 WC Toxicology SC Toxicology GA AH8KX UT WOS:000336387800001 PM 24766293 ER PT J AU Borowicz, DT Bank, LC AF Borowicz, David T. Bank, Lawrence C. TI Web Buckling in Pultruded Fiber-Reinforced Polymer Deep Beams Subjected to Concentrated Loads SO JOURNAL OF COMPOSITES FOR CONSTRUCTION LA English DT Article DE Bearing plate; Buckling failure; Concentrated loads; Deep FRP beams; Digital image correlation ID DESIGN; TESTS AB Five 609.5-mm deep fiber-reinforced polymer (FRP) beams with a span-to-depth ratio of 4: 1 were tested in three-point bending with the beam ends constrained to prevent global failure. A concentrated load was applied at midspan either directly to the top flange or through a 101.6 mm wide by 12.7-mm thick FRP bearing plate resting on the top flange. VIC-3D Digital Image Correlation Measurement Software from Correlated Solutions captured out-of-plane displacement of the webs, and Southwell plots were generated to determine buckling loads. Each specimen experienced a stability failure of the web before undergoing material failure in the upper web-flange junction. On average, web buckling occurred at 90% of the ultimate load. The introduction of a bearing plate did not significantly affect the buckling load or ultimate capacity of the specimens. One specimen was tested into the postbuckling range, unloaded, and reloaded to material failure and experienced no loss of strength or stiffness. Another specimen with significant damage to the unloaded web-flange junction was tested and compared with a virgin sample. The damaged sample experienced no significant loss of strength or stiffness. Comparisons of experimental data with three theoretical equations for web-buckling capacity of FRP beams are provided. (C) 2013 American Society of Civil Engineers. C1 [Borowicz, David T.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. [Bank, Lawrence C.] CUNY City Coll, Dept Civil Engn, New York, NY 10031 USA. RP Borowicz, DT (reprint author), US Mil Acad, Dept Civil & Mech Engn, 752 Thayer Rd,331 Mahan Hall, West Point, NY 10996 USA. EM david.borowicz@usma.edu; lbank2@ccny.cuny.edu NR 24 TC 0 Z9 0 U1 3 U2 12 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1090-0268 EI 1943-5614 J9 J COMPOS CONSTR JI J. Compos. Constr. PD JUN PY 2014 VL 18 IS 3 SI SI AR A4013014 DI 10.1061/(ASCE)CC.1943-5614.0000360 PG 8 WC Engineering, Civil; Mechanics; Materials Science, Composites SC Engineering; Mechanics; Materials Science GA AH6OH UT WOS:000336249800014 ER PT J AU Russell, MM Hsiang, SM Liu, M Wambeke, B AF Russell, Marion M. Hsiang, Simon M. Liu, Min Wambeke, Brad TI Causes of Time Buffer and Duration Variation in Construction Project Tasks: Comparison of Perception to Reality SO JOURNAL OF CONSTRUCTION ENGINEERING AND MANAGEMENT LA English DT Article ID REDUCING VARIABILITY; IMPROVE PERFORMANCE; PRODUCTIVITY; CONTINGENCY; MOTIVATION; MANAGEMENT; PRINCIPLE; MODEL; RISK C1 [Russell, Marion M.; Liu, Min] N Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA. [Hsiang, Simon M.] Texas Tech Univ, Lubbock, TX 79409 USA. [Wambeke, Brad] US Mil Acad, Civil & Mech Engn Dept, West Point, NY 10996 USA. RP Liu, M (reprint author), N Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA. EM mmrusse2@ncsu.edu; simon.hsiang@ttu.edu; min_liu@ncsu.edu; bwwambek@ncsu.edu NR 39 TC 0 Z9 0 U1 0 U2 4 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9364 EI 1943-7862 J9 J CONSTR ENG M JI J. Constr. Eng. Manage. PD JUN 1 PY 2014 VL 140 IS 6 PG 12 WC Construction & Building Technology; Engineering, Industrial; Engineering, Civil SC Construction & Building Technology; Engineering GA AH1KV UT WOS:000335880000008 ER PT J AU Bianchini, A AF Bianchini, Alessandra TI Pavement Maintenance Planning at the Network Level with Principal Component Analysis SO JOURNAL OF INFRASTRUCTURE SYSTEMS LA English DT Article DE Principal-component analysis; Pavement performance; Flexible pavement ID STRUCTURAL SYSTEM-IDENTIFICATION; WEIGHT DEFLECTOMETER DEFLECTIONS; ASPHALT PAVEMENT; PERFORMANCE; PREDICTION; INDICATORS AB Pavement management relies on the evaluation of the condition of pavement at different times during the life of the structure. The combination of condition indicators and the knowledge of how they are used in any pavement condition model is fundamental for pavement rating. To handle complexity and information redundancy, this paper proposes the principal-component analysis (PCA) to evaluate the relative importance of different types of distresses on the condition assessment for flexible pavements, and to use relevant condition features to establish criteria for pavement management. The important outcomes in applying the PCA approach were: even with the dimensionality reduction dictated by the variance, there was limited loss of information with regard to the section condition that did not affect the overall objective of pavement management; also, information redundancy was minimized. (C) 2013 American Society of Civil Engineers. C1 US Army, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Bianchini, A (reprint author), US Army, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM alessandra.bianchini@usace.army.mil NR 37 TC 3 Z9 3 U1 8 U2 19 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1076-0342 EI 1943-555X J9 J INFRASTRUCT SYST JI J. Infrastruct. Syst. PD JUN 1 PY 2014 VL 20 IS 2 AR 04013013 DI 10.1061/(ASCE)IS.1943-555X.0000189 PG 8 WC Engineering, Civil SC Engineering GA AH6QR UT WOS:000336256300008 ER PT J AU Shah, S Bellam, N Leipsic, J Berman, DS Quyyumi, A Hausleiter, J Achenbach, S Al-Mallah, M Budoff, MJ Cademartiri, F Callister, TQ Chang, HJ Chow, BJW Cury, RC Delago, AJ Dunning, AL Feuchtner, GM Hadamitzky, M Karlsberg, RP Kaufmann, PA Lin, FY Chinnaiyan, KM Maffei, E Raff, GL Villines, TC Gomez, MJ Min, JK Shaw, LJ AF Shah, Sana Bellam, Naveen Leipsic, Jonathon Berman, Daniel S. Quyyumi, Arshed Hausleiter, Joerg Achenbach, Stephan Al-Mallah, Mouaz Budoff, Matthew J. Cademartiri, Fillippo Callister, Tracy Q. Chang, Hyuk-Jae Chow, Benjamin J. W. Cury, Ricardo C. Delago, Augustin J. Dunning, Allison L. Feuchtner, Gudrun M. Hadamitzky, Martin Karlsberg, Ronald P. Kaufmann, Philipp A. Lin, Fay Y. Chinnaiyan, Kavitha M. Maffei, Erica Raff, Gilbert L. Villines, Todd C. Gomez, Millie J. Min, James K. Shaw, Leslee J. CA CONFIRM COronary CT Angiography Ev TI Prognostic significance of calcified plaque among symptomatic patients with nonobstructive coronary artery disease SO JOURNAL OF NUCLEAR CARDIOLOGY LA English DT Article DE Coronary calcification; prognosis; nonobstructive coronary artery disease ID ALL-CAUSE MORTALITY; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; EXPERT CONSENSUS DOCUMENT; INTRAVASCULAR ULTRASOUND; CARDIOVASCULAR RISK; AMERICAN-COLLEGE; CALCIUM; CALCIFICATION; ATHEROSCLEROSIS; QUANTIFICATION AB Coronary artery calcium (CAC) is a well-established predictor of clinical outcomes for population screening. Limited evidence is available as to its predictive value in symptomatic patients without obstructive coronary artery disease (CAD). The aim of the current study was to assess the prognostic value of CAC scores among symptomatic patients with nonobstructive CAD. From the COronary Computed Tomographic Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter (CONFIRM) registry, 7,200 symptomatic patients with nonobstructive CAD (< 50% coronary stenosis) on coronary-computed tomographic angiography were prospectively enrolled and followed for a median of 2.1 years. Patients were categorized as without (0% stenosis) or with (> 0% but < 50% coronary stenosis) a luminal stenosis. CAC scores were calculated using the Agatston method. Univariable and multivariable Cox proportional hazard models were employed to estimate all-cause mortality and/or myocardial infarction (MI). Four-year death and death or MI rates were 1.9% and 3.3%. Of the 4,380 patients with no luminal stenosis, 86% had CAC scores of < 10 while those with a luminal stenosis had more prevalent and extensive CAC with 31.9% having a CAC score of a parts per thousand yen100. Among patients with no luminal stenosis, CAC was not predictive of all-cause mortality (P = .44). However, among patients with a luminal stenosis, 4-year mortality rates ranged from 0.8% to 9.8% for CAC scores of 0 to a parts per thousand yen400 (P < .0001). The mortality hazard was 6.0 (P = .004) and 13.3 (P < .0001) for patients with a CAC score of 100-399 and a parts per thousand yen400. In patients with a luminal stenosis, CAC remained independently predictive in all-cause mortality (P < .0001) and death or MI (P < .0001) in multivariable models containing CAD risk factors and presenting symptoms. CAC allows for the identification of those at an increased hazard for death or MI in symptomatic patients with nonobstructive disease. From the CONFIRM registry, the extent of CAC was an independent estimator of long-term prognosis among symptomatic patients with luminal stenosis and may further define risk and guide preventive strategies in patients with nonobstructive CAD. C1 [Shah, Sana; Bellam, Naveen; Quyyumi, Arshed; Shaw, Leslee J.] Emory Univ, Sch Med, Dept Med, Emory Clin Cardiovasc Res Inst, Atlanta, GA 30322 USA. [Leipsic, Jonathon] Univ British Columbia, St Pauls Hosp, Dept Radiol, Vancouver, BC V5Z 1M9, Canada. [Berman, Daniel S.; Gomez, Millie J.; Min, James K.] Cedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA. [Hausleiter, Joerg] Tech Univ Munich, Div Cardiol, D-80290 Munich, Germany. [Achenbach, Stephan] Univ Giessen, Dept Med, D-35390 Giessen, Germany. [Al-Mallah, Mouaz] King Abdulaziz Cardiac Ctr, Dept Med, Riyadh, Saudi Arabia. [Budoff, Matthew J.] Harbor UCLA Med Ctr, Dept Med, Los Angeles, CA USA. [Cademartiri, Fillippo] Giovanni XXIII Hosp, Cardiovasc Imaging Unit, Monastier Di Treviso, Italy. [Callister, Tracy Q.] Tennessee Heart & Vasc Inst, Hendersonville, TN USA. [Chang, Hyuk-Jae] Severance Cardiovasc Hosp, Div Cardiol, Seoul, South Korea. [Chow, Benjamin J. W.] Univ Ottawa, Inst Heart, Dept Med Cardiol, Ottawa, ON, Canada. [Cury, Ricardo C.] Baptist Hosp Miami, Miami, FL USA. [Cury, Ricardo C.] Baptist Cardiac & Vasc Inst, Miami, FL USA. [Delago, Augustin J.] Capital Cardiol Associates, Albany, NY USA. [Dunning, Allison L.; Lin, Fay Y.] Weill Cornell Med Coll, Dept Publ Hlth & Med, New York, NY USA. [Dunning, Allison L.; Lin, Fay Y.] New York Presbyterian Hosp, New York, NY USA. [Feuchtner, Gudrun M.] Med Univ Innsbruck, Dept Radiol 2, A-6020 Innsbruck, Austria. [Hadamitzky, Martin] German Heart Ctr, Munich, Germany. [Karlsberg, Ronald P.] Cardiovasc Med Grp, Beverly Hills, CA USA. [Kaufmann, Philipp A.] William Beaumont Hosp, Dept Cardiol, Royal Oak, MI 48072 USA. [Chinnaiyan, Kavitha M.; Raff, Gilbert L.] Univ Zurich Hosp, CH-8091 Zurich, Switzerland. [Maffei, Erica; Villines, Todd C.] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. RP Shaw, LJ (reprint author), Emory Univ, Sch Med, Dept Med, Emory Clin Cardiovasc Res Inst, 1462 Clifton Rd NE,Room 529, Atlanta, GA 30322 USA. EM lshaw3@emory.edu RI Cademartiri, Filippo/H-7336-2015; Maffei, Erica/J-2370-2016; OI Cademartiri, Filippo/0000-0002-0579-3279; Maffei, Erica/0000-0002-0388-4433; Al-Mallah, Mouaz/0000-0003-2348-0484 FU Siemens; Bayer Schering Pharma; Bayer Phama; Blue Cross Blue Shield of Michigan; GE Healthcare; Servier; Siemens Medical Systems FX The following authors declared conflicts of interest: Stephan Achenbach: (Grant Support: Siemens and Bayer Schering Pharma; Consultant: Servier); Mouaz Al-Mallah (Consultant: Astellas); Matthew Budoff (Consultant: GE Healthcare); Filippo Cademartiri (Speaker's Bureau: Bracco Diagnostics; Consultant: Guerbet); Kavitha Chinnaiyan (Grant Support: Bayer Phama, Blue Cross Blue Shield of Michigan); Benjamin Chow (Grant Support and Consultant: GE Healthcare; Grant Support: Servier; Educational Support: TeraRecon); Ricardo Cury (Consultant: Astellas Pharma, GE Healthcare, Novartis); Joerg Hausleiter (Grant Support: Siemens Medical Systems); Philipp Kaumann (Grant Support: GE Healthcare); Jonathon Leipsic (Speaker's Bureau: GE Healthcare, Edwards Lifesciences, Heartflow, and Circle CVI); Gilbert Raff (Grant Support: Siemens, Bayer Pharma). The remainder of the authors have no disclosures. NR 33 TC 10 Z9 10 U1 1 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1071-3581 EI 1532-6551 J9 J NUCL CARDIOL JI J. Nucl. Cardiol. PD JUN PY 2014 VL 21 IS 3 BP 453 EP 466 DI 10.1007/s12350-014-9865-9 PG 14 WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical Imaging SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine & Medical Imaging GA AH6YI UT WOS:000336278000005 PM 24683047 ER PT J AU Grussing, MN Liu, LY AF Grussing, Michael N. Liu, Liang Y. TI Knowledge-Based Optimization of Building Maintenance, Repair, and Renovation Activities to Improve Facility Life Cycle Investments SO JOURNAL OF PERFORMANCE OF CONSTRUCTED FACILITIES LA English DT Article DE Buildings; Asset management; Condition assessment; Facility life cycle; Optimization ID MANAGEMENT AB Buildings and related civil infrastructure are an important factor of production that contribute directly to the accomplishment of an organization's mission and/or the generation of revenue. Aging, obsolescence, and general deterioration of these buildings, and their systems and components, can adversely affect the ability to accomplish a mission or generate expected revenue, thus resulting in an elevated risk profile. Maintenance, repair, and renovation (MR&R) activities, when planned effectively, can affect performance in such a way to reduce this risk. A rapidly aging infrastructure and building stock in the United States and across the world jeopardizes the ability to generate output and accomplish a mission at status quo. Moreover, rapidly expanding demands on some infrastructure will likewise make the status quo greatly inadequate in the near future. This requires two highly interrelated strategies: (1) to introduce new capabilities and capacities into the infrastructure stock to meet projected demand; and (2) to adequately manage, maintain, improve, and renew the existing infrastructure stock to slow performance degradation and fill demand gaps. The objective of this study is to develop a methodology for rapidly identifying and selecting multiyear building MR&R activities, such that facility performance is maximized and life cycle costs are minimized. This is a significant step toward the development of a comprehensive facility life cycle MR&R model that incorporates infrastructure economics and uncertainty for improved decision making. The result of this study is a model framework, to be applied against a building or group of buildings, which selects the optimum mixture of work activities considering condition, capability, performance, and life cycle costs. A genetic algorithm is employed to optimize the activity selection, and the proposed model approach is implemented against an example building to illustrate the methodology. C1 [Grussing, Michael N.] US Army Corps Engineers, Engn Res & Dev Ctr, Champaign, IL 61822 USA. [Liu, Liang Y.] Univ Illinois, Dept Civil & Environm Engn, Urbana, IL 61801 USA. RP Grussing, MN (reprint author), US Army Corps Engineers, Engn Res & Dev Ctr, Champaign, IL 61822 USA. EM michael.n.grussing@usace.army.mil RI Johnson, Marilyn/E-7209-2011 NR 28 TC 3 Z9 3 U1 6 U2 39 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0887-3828 EI 1943-5509 J9 J PERFORM CONSTR FAC JI J. Perform. Constr. Facil. PD JUN PY 2014 VL 28 IS 3 BP 539 EP 548 DI 10.1061/(ASCE)CF.1943-5509.0000449 PG 10 WC Construction & Building Technology; Engineering, Civil SC Construction & Building Technology; Engineering GA AH6NE UT WOS:000336246800013 ER PT J AU Mata, DG Rezk, PE Sabnekar, P Cerasoli, DM Chilukuri, N AF Mata, David G. Rezk, Peter E. Sabnekar, Praveena Cerasoli, Douglas M. Chilukuri, Nageswararao TI Investigation of Evolved Paraoxonase-1 Variants for Prevention of Organophosphorous Pesticide Compound Intoxication SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS LA English DT Article ID HUMAN BUTYRYLCHOLINESTERASE; NERVE AGENTS; GUINEA-PIGS; PROTECTION; SOMAN; TOXICITY; PON1; PRETREATMENT; PROPHYLAXIS; HYDROLASES AB We investigated the ability of the engineered paraoxonase-1 variants G3C9, VII-D11, I-F11, and VII-D2 to afford protection against paraoxon intoxication. Paraoxon is the toxic metabolite of parathion, a common pesticide still in use in many developing countries. An in vitro investigation showed that VII-D11 is the most efficient variant at hydrolyzing paraoxon with a k(cat)/K-m of 2.1 Chi 10(6) M-1 min(-1) and 1.6 Chi 10(6) M-1 min(-1) for the enzyme expressed via adenovirus infection of 293A cells and mice, respectively. Compared with the G3C9 parent scaffold, VII-D11 is 15- to 20- fold more efficacious at hydrolyzing paraoxon. Coinciding with these results, mice expressing VII-D11 in their blood survived and showed no symptoms against a cumulative 6.3 Chi LD50 dose of paraoxon, whereas mice expressing G3C9 experienced tremors and only 50% survival. We then determined whether VII-D11 can offer protection against paraoxon when present at substoichiometric concentrations. Mice containing varying concentrations of VII-D11 in their blood ( 0.2-4.1 mg/ml) were challenged with doses of paraoxon at fixed stoichiometric ratios that constitute up to a 10-fold molar excess of paraoxon to enzyme ( 1.4-27 Chi LD50 doses) and were assessed for tremors and mortality. Mice were afforded complete asymptomatic protection below a paraoxon-to-enzyme ratio of 8: 1, whereas higher ratios produced tremors and/or mortality. VII-D11 in mouse blood coeluted with high-density lipoprotein, suggesting an association between the two entities. Collectively, these results demonstrate that VII-D11 is a promising candidate for development as a prophylactic catalytic bioscavenger against organophosphorous pesticide toxicity. C1 [Mata, David G.; Rezk, Peter E.; Sabnekar, Praveena; Cerasoli, Douglas M.; Chilukuri, Nageswararao] US Army Med Res Inst Chem Def, Div Res, Physiol & Immunol Branch, Aberdeen Proving Ground, MD 21010 USA. RP Chilukuri, N (reprint author), US Army Med Res Inst Chem Def, Div Res, Physiol & Immunol Branch, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM Nageswararao.chilukuri.civ@mail.mil FU Defense Threat Reduction Agency; Joint Science and Technology Office; Medical ST Division FX This research was supported by the Defense Threat Reduction Agency, Joint Science and Technology Office, Medical S&T Division ( to N.C.). NR 34 TC 8 Z9 8 U1 1 U2 10 PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA SN 0022-3565 EI 1521-0103 J9 J PHARMACOL EXP THER JI J. Pharmacol. Exp. Ther. PD JUN PY 2014 VL 349 IS 3 BP 549 EP 558 DI 10.1124/jpet.114.213645 PG 10 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA AH5GJ UT WOS:000336156200021 PM 24706983 ER PT J AU Meeks, JJ Kern, SQ Dalbagni, G Eastham, JA Sandhu, JS AF Meeks, Joshua J. Kern, Sean Q. Dalbagni, Guido Eastham, James A. Sandhu, Jaspreet S. TI The Prevalence of Persistent Prostate Cancer after Radiotherapy Detected at Radical Cystoprostatectomy for Bladder Cancer SO JOURNAL OF UROLOGY LA English DT Article DE prostatic neoplasms; neoplasm recurrence, local; radiotherapy; urinary bladder neoplasms; cystectomy ID BEAM RADIATION-THERAPY; RELAPSE-FREE SURVIVAL; PREDICTIVE-VALUE; SPECIMENS; OUTCOMES; BIOPSY AB Purpose: More than half of the men who receive treatment for prostate cancer elect radiotherapy. After radiotherapy recurrence is determined by an increase in prostate specific antigen and not usually by pathological confirmation. We describe the prevalence of persistent gradable prostate cancer in men treated with radiotherapy for prostate cancer at radical cystoprostatectomy for bladder cancer. Materials and Methods: A total of 78 patients underwent radiotherapy (brachytherapy and/or external beam radiation) before the development of bladder cancer requiring radical cystectomy at our institution. All tissues were evaluated by a specialized genitourinary pathologist. Results: Median time from radiotherapy to radical cystoprostatectomy was 77 months. Gradable prostate cancer was identified in 45% of patients. Of the tumors 69% were Gleason score 7 or greater, 17% were pT3 or greater and 5% showed positive lymph nodes. Men treated more recently were less likely to have gradable prostate cancer, including 100% before 1980, 49% between 1980 and 2000 and 10% from 2000 to the present (p = 0.002) as were those who received external beam radiation alone compared to brachytherapy and combined brachytherapy/external beam radiation (58% vs 27% and 14%, respectively, p = 0.005). Conclusions: After radiotherapy 45% of men had persistent prostate cancer (37% of men with no evidence of disease). A decreased prostate cancer rate was associated with later treatment year and combined brachytherapy/external beam radiation regimens. Similar to men treated with radical cystoprostatectomy for muscle invasive bladder cancer, meticulous attention should be paid during prostate removal in men treated with radiotherapy because many may have persistent prostate cancer. In addition, markers other than prostate specific antigen should be studied in men treated with radiotherapy to better identify those with biochemical recurrence. C1 [Sandhu, Jaspreet S.] Mem Sloan Kettering Canc Ctr, Dept Surg, Urol Serv, New York, NY 10021 USA. [Kern, Sean Q.] Tripler Army Med Ctr, Dept Surg, Urol Serv, Honolulu, HI 96859 USA. RP Sandhu, JS (reprint author), Mem Sloan Kettering Canc Ctr, Dept Surg, Urol Serv, 353 East 68th St, New York, NY 10021 USA. EM sandhuj@mskcc.org FU Sidney Kimmel Center for Prostate and Urologic Cancers FX Supported by the Sidney Kimmel Center for Prostate and Urologic Cancers. NR 15 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-5347 EI 1527-3792 J9 J UROLOGY JI J. Urol. PD JUN PY 2014 VL 191 IS 6 BP 1760 EP 1763 DI 10.1016/j.juro.2013.12.037 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA AI0IS UT WOS:000336531100032 PM 24373801 ER PT J AU Wasserberg, G Kirsch, P Rowton, ED AF Wasserberg, G. Kirsch, P. Rowton, E. D. TI Orientation of colonized sand flies Phlebotomus papatasi, P. duboscqi, and Lutzomyia longipalpis (Diptera: Psychodidae) to diverse honeys using a 3-chamber in-line olfactometer SO JOURNAL OF VECTOR ECOLOGY LA English DT Article DE Sand fly; plant-based attractant baits; semiochemicals; olfactory attraction; leishmaniasis; biological control; area-wide pest management ID HUBNER LEPIDOPTERA-NOCTUIDAE; VOLATILE-BASED ATTRACTICIDE; JORDAN VALLEY; CUTANEOUS LEISHMANIASIS; MOSQUITOS DIPTERA; BOTANICAL ORIGIN; PLANT; SUGAR; SUSCEPTIBILITY; IDENTIFICATION AB A 3-chamber in-line olfactometer designed for use with sand flies is described and tested as a high-throughput method to screen honeys for attractiveness to Phlebotomus papatasi (four geographic isolates), P. duboscqi (two geographic isolates), and Lutzomyia longipalpis maintained in colonies at the Walter Reed Army Institute of Research. A diversity of unifloral honey odors were evaluated as a proxy for the natural floral odors that sand flies may use in orientation to floral sugar sources in the field. In the 3-chamber in-line olfactometer, the choice modules come directly off both sides of the release area instead of angling away as in the Y-tube olfactometer. Of the 25 honeys tested, five had a significant attraction for one or more of the sand fly isolates tested. This olfactometer and high-throughput method has utility for evaluating a diversity of natural materials with unknown complex odor blends that can then be down-selected for further evaluation in wind tunnels and/or field scenarios. C1 [Wasserberg, G.] Univ N Carolina, Dept Biol, Greensboro, NC 27402 USA. [Kirsch, P.] Univ Queensland, Minerals Ind Safety & Hlth Ctr, Brisbane, Qld 4072, Australia. [Rowton, E. D.] Walter Reed Army Inst Res, Dept Sand Fly Biol, Silver Spring, MD 20910 USA. RP Wasserberg, G (reprint author), Univ N Carolina, Dept Biol, Greensboro, NC 27402 USA. EM g_wasser@uncg.edu FU MIDRP, U.S. Department of Defense FX This research was funded by MIDRP, U.S. Department of Defense. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting true views of the Department of the Army or the Department of Defense. NR 45 TC 3 Z9 3 U1 2 U2 20 PU SOC VECTOR ECOLOGY PI CORONA PA 1966 COMPTON AVE, CORONA, CA 92881 USA SN 1081-1710 EI 1948-7134 J9 J VECTOR ECOL JI J. Vector Ecol. PD JUN PY 2014 VL 39 IS 1 BP 94 EP 102 DI 10.1111/j.1948-7134.2014.12075.x PG 9 WC Entomology SC Entomology GA AH3XJ UT WOS:000336059300012 PM 24820561 ER PT J AU Foley, DH Linton, YM Ruiz-Lopez, JF Conn, JE Sallum, MAM Povoa, MM Bergo, ES Oliveira, TMP Sucupira, I Wilkerson, RC AF Foley, Desmond H. Linton, Yvonne-Marie Freddy Ruiz-Lopez, J. Conn, Jan E. Sallum, Maria Anice M. Povoa, Marinete M. Bergo, Eduardo S. Oliveira, Tatiane M. P. Sucupira, Izis Wilkerson, Richard C. TI Geographic distribution, evolution, and disease importance of species within the Neotropical Anopheles albitarsis Group (Diptera, Culicidae) SO JOURNAL OF VECTOR ECOLOGY LA English DT Article DE Mosquito; ecological niche models; malaria; phylogenetics; SEEVA; Albitarsis Group ID COMPARATIVE SUSCEPTIBILITY; PLASMODIUM-FALCIPARUM; CONSERVATION GENETICS; POPULATION HISTORY; MALARIA VECTORS; NICHE MODELS; PHYLOGEOGRAPHY; BRAZIL; SPECIATION; TRANSMISSION AB The Anopheles albitarsis group of mosquitoes comprises eight recognized species and one mitochondrial lineage. Our knowledge of malaria vectorial importance and the distribution and evolution of these taxa is incomplete. We constructed ecological niche models (ENMs) for these taxa and used hypothesized phylogenetic relationships and ENMs to investigate environmental and ecological divergence associated with speciation events. Two major clades were identified, one north (Clade 1) and one south (Clade 2) of the Amazon River that likely is or was a barrier to mosquito movement. Clade 1 species occur more often in higher average temperature locations than Clade 2 species, and taxon splits within Clade 1 corresponded with a greater divergence of variables related to precipitation than was the case within Clade 2. Comparison of the ecological profiles of sympatric species and sister species support the idea that phylogenetic proximity is related to ecological similarity. Anopheles albitarsis I, An. janconnae, and An. marajoara ENMs had the highest percentage of their predicted suitable habitat overlapping distribution models of Plasmodium falciparum and P. vivax, and warrant additional studies of the transmission potential of these species. Phylogenetic proximity may be related to malaria vectorial importance within the Albitarsis Group. C1 [Foley, Desmond H.; Linton, Yvonne-Marie; Wilkerson, Richard C.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA. [Freddy Ruiz-Lopez, J.] Museum Support Ctr, Smithsonian Inst, Walter Reed Biosystemat Unit, Suitland, MD 20746 USA. [Freddy Ruiz-Lopez, J.] Univ Antioquia, PECET, Medellin, Colombia. [Conn, Jan E.] New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12159 USA. [Conn, Jan E.] SUNY Albany, Sch Publ Hlth, Dept Biomed Sci, Albany, NY 12222 USA. [Sallum, Maria Anice M.; Oliveira, Tatiane M. P.] Univ Sao Paulo, Fac Saude Publ, Dept Epidemiol, BR-05508 Sao Paulo, Brazil. [Povoa, Marinete M.; Sucupira, Izis] Inst Evandro Chagas, Ananindeua, Para, Brazil. [Bergo, Eduardo S.] Superintendencia Controle Endemias Estado Sao Paul, Sao Paulo, Brazil. RP Foley, DH (reprint author), Walter Reed Army Inst Res, Div Entomol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM foleydes@si.edu RI Oliveira, Tatiane/O-6518-2014; Sallum, Maria/B-8537-2012; OI BERGO, EDUARDO/0000-0003-4928-0368; Conn, Jan/0000-0002-5301-7020; Foley, Desmond/0000-0001-7525-4601 FU Global Emerging Infections Surveillance and Response System (a Division of the Armed Forces Health Surveillance Center - AFHSC/Div of GEIS Ops) [P0149_13_WR]; National Institute of Health, USA [R01 AI50139-02]; Foundation for Research Support of the State of Sao Paulo, FAPESP [2011/20397-7]; National Research Council Research Associateship Award at the Walter Reed Army Institute of Research FX This investigation received financial support from the Global Emerging Infections Surveillance and Response System (a Division of the Armed Forces Health Surveillance Center - AFHSC/Div of GEIS Ops) (grant P0149_13_WR to DHF); from the National Institute of Health, USA (grant R01 AI50139-02 to JEC); and from the Foundation for Research Support of the State of Sao Paulo, FAPESP (Processo no. 2011/20397-7 to MAMS). This manuscript was prepared while YML held a National Research Council Research Associateship Award at the Walter Reed Army Institute of Research. We thank Simon Hay, Carlos Guerra, Catherine Moyes, and Peter Gething of the Malaria Atlas Project for access to malaria models. This research was performed under a Memorandum of Understanding between the Walter Reed Army Institute of Research and the Smithsonian Institution, with institutional support provided by both organizations. The published material reflects the views of the authors and should not be construed to represent those of the Department of the Army or the Department of Defense. NR 33 TC 6 Z9 6 U1 0 U2 18 PU SOC VECTOR ECOLOGY PI CORONA PA 1966 COMPTON AVE, CORONA, CA 92881 USA SN 1081-1710 EI 1948-7134 J9 J VECTOR ECOL JI J. Vector Ecol. PD JUN PY 2014 VL 39 IS 1 BP 168 EP 181 DI 10.1111/j.1948-7134.2014.12084.x PG 14 WC Entomology SC Entomology GA AH3XJ UT WOS:000336059300021 PM 24820570 ER PT J AU Zubko, E Muinonen, K Videen, G Kiselev, NN AF Zubko, Evgenij Muinonen, Karri Videen, Gorden Kiselev, Nikolai N. TI Dust in Comet C/1975 V1 (West) SO MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY LA English DT Article DE polarization; scattering; methods: numerical; comets: individual: Comet C/1975 V1 (West) ID DISCRETE-DIPOLE APPROXIMATION; NARROW-BAND PHOTOMETRY; INFRARED OBSERVATIONS; HALE-BOPP; 81P/WILD 2; POLARIMETRIC OBSERVATIONS; OPTICAL POLARIMETRY; PHASE ANGLES; HALLEY DUST; SCATTERING AB We analyse the photopolarimetric response measured in Comet C/1975 V1 (West) using model agglomerated debris particles. Such particles have highly irregular morphology and volume density with properties that are consistent with the samples retrieved by Stardust from Comet 81P/Wild 2. We find that an entire set of observational data including phase function, phase dependence of the degree of linear polarization, photometric, and polarimetric colour in Comet C/1975 V1 (West) can be quantitatively reproduced with a two-component mixture of weakly and highly absorbing particles, having refractive indices m = 1.5+0i or 1.6+0.0005i and 2.43+0.59i, respectively. These refractive indices are consistent with Mg-rich silicates and amorphous carbon, two species considered to be abundant in comets. Our modelling predicts the volume ratio of these materials being about 1:3. We note that in situ mass spectrometry measurements of Comet 1P/Halley suggested a similar ratio of weakly to highly absorbing particles, with a large uncertainty. The best fit to observations is obtained for a polydisperse ensembles of particles that obey the power-law size distribution r(-1.5) and r(-2). Such a distribution also is in good agreement with in situ studies of Comet 1P/Halley. While our modelling can reproduce the photopolarimetric properties of Comet C/1975 V1 (West), it also is one of the simplest approach, since it has fewer free parameters than other approaches. C1 [Zubko, Evgenij] Kharkov Natl Univ, Inst Astron, UA-61022 Kharkov, Ukraine. [Muinonen, Karri] Univ Helsinki, Dept Phys, FIN-00014 Helsinki, Finland. [Muinonen, Karri] Finnish Geodet Inst, FI-02431 Masala, Finland. [Videen, Gorden] Space Sci Inst, Boulder, CO 80301 USA. [Videen, Gorden] US Army Res Lab, Adelphi, MD 20783 USA. [Kiselev, Nikolai N.] Natl Acad Sci Ukraine, Main Astron Observ, UA-03680 Kiev, Ukraine. RP Zubko, E (reprint author), Kharkov Natl Univ, Inst Astron, 35 Sumskaya St, UA-61022 Kharkov, Ukraine. EM ezubko@rambler.ru FU ERC [320773]; Academy of Finland [257966]; NASA [NNX10AP93G] FX This work was partially supported by the ERC Advanced Grant No 320773 entitled 'Scattering and Absorption of Electromagneetic Waves in Particulate Media' (SAEMPL), by the Academy of Finland (contract 257966), and by NASA program for Outer Planets Research (grant NNX10AP93G). We are grateful to Professor A. Ch. Levasseur-Regourd for valuable comments on this paper. NR 69 TC 8 Z9 8 U1 0 U2 6 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0035-8711 EI 1365-2966 J9 MON NOT R ASTRON SOC JI Mon. Not. Roy. Astron. Soc. PD JUN PY 2014 VL 440 IS 4 BP 2928 EP 2943 DI 10.1093/mnras/stu480 PG 16 WC Astronomy & Astrophysics SC Astronomy & Astrophysics GA AH6AT UT WOS:000336213800004 ER PT J AU Corona, BT Garg, K Roe, JL Zhu, H Park, KH Ma, JJ Walters, TJ AF Corona, Benjamin T. Garg, Koyal Roe, Janet L. Zhu, Hua Park, Ki Ho Ma, Jianjie Walters, Thomas J. TI EFFECT OF RECOMBINANT HUMAN MG53 PROTEIN ON TOURNIQUET-INDUCED ISCHEMIA-REPERFUSION INJURY IN RAT MUSCLE SO MUSCLE & NERVE LA English DT Article DE ischemia-reperfusion; MG53; muscle injury; tourniquet; TRIM72 ID MEMBRANE REPAIR; SKELETAL-MUSCLE; COMPARTMENT SYNDROME AB Introduction: Skeletal muscle ischemia-reperfusion injury (I-R) is a complex injury process that includes damage to the sarcolemmal membrane, contributing to necrosis and apoptosis. MG53, a muscle-specific TRIM family protein, has been shown to be essential for regulating membrane repair and has been shown to be protective against cardiac I-R and various forms of skeletal muscle injury. The purpose of this study was to determine if recombinant human MG53 (rhMG53) administration offered protection against I-R. Methods: rhMG53 was administered to rats immediately before tourniquet-induced ischemia and again immediately before reperfusion. Two days later muscle damage was assessed histologically. Results: rhMG53 offered no protective effect, as evidenced primarily by similar Evans blue dye inclusion in the muscles of rats administered rhMG53 or saline. Conclusions: Administration of rhMG53 does not offer protection against I-R in rat skeletal muscle. Additional studies are required to determine if the lack of a response is species-specific. Muscle Nerve49: 919-921, 2014 C1 [Corona, Benjamin T.; Garg, Koyal; Roe, Janet L.; Walters, Thomas J.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Zhu, Hua; Park, Ki Ho; Ma, Jianjie] Ohio State Univ, Wexner Med Ctr, Davis Heart & Lung Res Inst, Dept Surg, Columbus, OH 43210 USA. RP Walters, TJ (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM thomas.j.walters22.civ@mail.mil RI Zhu, Hua/G-4409-2010 FU U.S. Army Medical Research and Medical Command [F_025_2010_USAISR]; National Institutes of Health FX This work was funded by the U.S. Army Medical Research and Medical Command (grant: F_025_2010_USAISR) awarded to T.J.W., and National Institutes of Health grant awarded to J.M. All animal protocols were approved by the U.S. Army Institute of Surgical Research Animal Care and Use Committee. This study adhered to National Institutes of Health guidelines for the care and use of laboratory animals (DHHS Publication, NIH, 86 to 23). All components of this study including the decision where to publish were at the sole discretion of the authors. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or reflecting the views of the Department of Defense (AR 360-5) or the United States Government. Some of the authors are employees of the U.S. government, and this work was prepared as part of their official duties. NR 16 TC 3 Z9 5 U1 1 U2 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0148-639X EI 1097-4598 J9 MUSCLE NERVE JI Muscle Nerve PD JUN PY 2014 VL 49 IS 6 BP 919 EP 921 DI 10.1002/mus.24160 PG 3 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA AH2MA UT WOS:000335954400018 PM 24395153 ER PT J AU Prager, EM Aroniadou-Anderjaska, V Almeida-Suhett, CP Figueiredo, TH Apland, JP Rossetti, F Olsen, CH Braga, MFM AF Prager, Eric M. Aroniadou-Anderjaska, Vassiliki Almeida-Suhett, Camila P. Figueiredo, Taiza H. Apland, James P. Rossetti, Franco Olsen, Cara H. Braga, Maria F. M. TI The recovery of acetylcholinesterase activity and the progression of neuropathological and pathophysiological alterations in the rat basolateral amygdala after soman-induced status epilepticus: Relation to anxiety-like behavior SO NEUROPHARMACOLOGY LA English DT Article DE Soman; Status epilepticus; Basolateral amygdala; Acetylcholinesterase; Anxiety; Long-term potentiation ID POSTTRAUMATIC-STRESS-DISORDER; RECEPTOR ANTAGONIST LY293558; INDUCED SEIZURE ACTIVITY; INDUCED NEURONAL INJURY; LONG-TERM CONSEQUENCES; AGENT-INDUCED SEIZURE; TOKYO SUBWAY ATTACK; NERVE AGENTS; CHOLINE-ACETYLTRANSFERASE; ELECTRICAL-STIMULATION AB Organophosphorus nerve agents are powerful neurotoxins that irreversibly inhibit acetylcholinesterase (AChE) activity. One of the consequences of AChE inhibition is the generation of seizures and status epilepticus (SE), which cause brain damage, resulting in long-term neurological and behavioral deficits. Increased anxiety is the most common behavioral abnormality after nerve agent exposure. This is not surprising considering that the amygdala, and the basolateral nucleus of the amygdala (BLA) in particular, plays a central role in anxiety, and this structure suffers severe damage by nerve agent-induced seizures. In the present study, we exposed male rats to the nerve agent soman, at a dose that induce SE, and determined the time course of recovery of AChE activity, along with the progression of neuropathological and pathophysiological alterations in the BLA, during a 30-day period after exposure. Measurements were taken at 24 h, 7 days, 14 days, and 30 days after exposure, and at 14 and 30 days, anxiety-like behavior was also evaluated. We found that more than 90% of AChE is inhibited at the onset of SE, and AChE inhibition remains at this level 24 h later, in the BLA, as well as in the hippocampus, piriform cortex, and prelimbic cortex, which we analyzed for comparison. AChE activity recovered by day 7 in the BLA and day 14 in the other three regions. Significant neuronal loss and neurodegeneration were present in the BLA at 24 h and throughout the 30-day period. There was no significant loss of GABAergic interneurons in the BLA at 24 h post-exposure. However, by day 7, the number of GABAergic interneurons in the BLA was reduced, and at 14 and 30 days after soman, the ratio of GABAergic interneurons to the total number of neurons was lower compared to controls. Anxiety-like behavior in the open-field and the acoustic startle response tests was increased at 14 and 30 days post-exposure. Accompanying pathophysiological alterations in the BLA studied in in vitro brain slices included a reduction in the amplitude of field potentials evoked by stimulation of the external capsule, along with prolongation of their time course and an increase in the paired-pulse ratio. Long-term potentiation was impaired at 24 h, 7 days, and 14 days post-exposure. The loss of GABAergic interneurons in the BLA and the decreased interneuron to total number of neurons ratio may be the primary cause of the development of anxiety after nerve agent exposure. Published by Elsevier Ltd. C1 [Prager, Eric M.; Aroniadou-Anderjaska, Vassiliki; Almeida-Suhett, Camila P.; Figueiredo, Taiza H.; Rossetti, Franco; Braga, Maria F. M.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA. [Aroniadou-Anderjaska, Vassiliki; Braga, Maria F. M.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Psychiat, Bethesda, MD 20814 USA. [Prager, Eric M.; Aroniadou-Anderjaska, Vassiliki; Almeida-Suhett, Camila P.; Braga, Maria F. M.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Program Neurosci, Bethesda, MD 20814 USA. [Olsen, Cara H.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Biostat Consulting Ctr, Bethesda, MD 20814 USA. [Apland, James P.] US Army, Med Res Inst Chem Def, Neurotoxicol Branch, Aberdeen Proving Ground, MD 21010 USA. RP Braga, MFM (reprint author), Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Anat Physiol & Genet, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM maria.braga@usuhs.edu RI Prager, Eric/O-1567-2015 OI Prager, Eric/0000-0002-3810-0985 FU CounterACT Program, National Institutes of Health, Office of the Director and the National Institute of Neurologic Disorders and Stroke [5U01NS05816207]; Defense Threat Reduction Agency-Joint Science and Technology Office, Medical ST Division [CBM.NEURO.01.10.US.18, CBM.NEURO.01.10.US.15] FX This work was supported by the CounterACT Program, National Institutes of Health, Office of the Director and the National Institute of Neurologic Disorders and Stroke [Grant Number 5U01NS058162-07], and the Defense Threat Reduction Agency-Joint Science and Technology Office, Medical S&T Division [Grant Numbers CBM.NEURO.01.10.US.18 and CBM.NEURO.01.10.US.15]. NR 97 TC 13 Z9 13 U1 0 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0028-3908 EI 1873-7064 J9 NEUROPHARMACOLOGY JI Neuropharmacology PD JUN PY 2014 VL 81 BP 64 EP 74 DI 10.1016/j.neuropharm.2014.01.035 PG 11 WC Neurosciences; Pharmacology & Pharmacy SC Neurosciences & Neurology; Pharmacology & Pharmacy GA AG7XP UT WOS:000335632400007 PM 24486384 ER PT J AU Lawson, BK Jenne, JW Koebbe, CJ AF Lawson, Bryan K. Jenne, Joel W. Koebbe, Christopher J. TI Cauda equina and conus medullaris avulsion with herniation after midlumbar chance fracture SO SPINE JOURNAL LA English DT Editorial Material C1 [Lawson, Bryan K.; Jenne, Joel W.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, JBSA Ft Sam, Houston, TX 78234 USA. [Koebbe, Christopher J.] Brooke Army Med Ctr, Dept Neurol Surg, JBSA Ft Sam, Houston, TX 78234 USA. RP Lawson, BK (reprint author), Brooke Army Med Ctr, Dept Orthopaed & Rehabil, JBSA Ft Sam, 3551 Roger Brooke Dr, Houston, TX 78234 USA. NR 4 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1529-9430 EI 1878-1632 J9 SPINE J JI Spine Journal PD JUN PY 2014 VL 14 IS 6 BP 1060 EP 1062 DI 10.1016/j.spinee.2013.11.032 PG 3 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA AH8UA UT WOS:000336412500033 PM 24291702 ER PT J AU Shiflett, SA Zinnert, JC Young, DR AF Shiflett, Sheri A. Zinnert, Julie C. Young, Donald R. TI Conservation of functional traits leads to shrub expansion across a chronosequence of shrub thicket development SO TREES-STRUCTURE AND FUNCTION LA English DT Article DE Chronosequence; Chlorophyll fluorescence; ETR; Hydraulic conductivity; Shrub expansion ID VIRGINIA BARRIER ISLANDS; MYRICA-CERIFERA; WATER-STRESS; CHLOROPHYLL FLUORESCENCE; PHYSIOLOGICAL-RESPONSES; HYDRAULIC CONDUCTIVITY; STOMATAL DENSITY; DROUGHT STRESS; FRESH-WATER; VEGETATION AB Robust physiology of Myrica cerifera across a chronosequence (i.e., space for time substitution) of shrub thicket age classes contributes to rapid cover expansion observed in the last 50 years. Many studies have documented the causes of woody expansion into grasslands, but few address unique morphological and physiological traits that facilitate expansion. Myrica cerifera, an evergreen N-fixer, is the dominant shrub on many barrier islands of the southeastern United States. Cover of Myrica cerifera has expanded by similar to 400 % on Hog Island, Virginia, in the past 50 years. Accretion of the northern end of the island has resulted in a chronosequence (i.e., space for time substitution) of both soil age and shrub thicket development. We investigated functional traits and physiological parameters related to light capture, processing and water balance of M. cerifera across shrub thickets of four age classes from similar to 10 to similar to 50 years. We hypothesized that light processing capabilities and hydraulic capacity would be reduced with thicket age. Spatial variation in morphology (i.e., leaf thickness, leaf area) and structure (i.e., leaf angle) related to light capture was observed. Yet, little or no differences were detected in stomatal density, photosynthetic pigments, electron transport rate (ETR) and hydraulic conductivity across sites. Previous research has shown declines in leaf N content, productivity and leaf litter production across the chronosequence. In contrast, we observed that physiology remains consistent despite considerable differences in thicket age and development. Myrica cerifera maintains high photosynthetic and hydraulic efficiency, factors which enable expansion and maintenance of shrub thickets in mesic coastal environments. C1 [Shiflett, Sheri A.; Zinnert, Julie C.; Young, Donald R.] Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA. [Zinnert, Julie C.] US Army ERDC, Fluorescence Spect Lab, Alexandria, VA 22315 USA. RP Young, DR (reprint author), Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA. EM dryoung@vcu.edu RI Young, Kristina/M-3069-2014 FU NSF [DEB-0621014] FX This study was supported in part by an NSF grant (DEB-0621014) to the University of Virginia for LTER-related work at the Virginia Coast Reserve. Andre Carapeto, Andrew McIntyre III and Paul Manley assisted with field work. Aaron Lee, Audrey Kirschner, Cameron Ashgarpour, and Jessica Daniels assisted with laboratory analysis. The authors thank the VCR-LTER laboratory staff for accommodating logistical and temporal sampling needs. NR 60 TC 3 Z9 4 U1 1 U2 14 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0931-1890 EI 1432-2285 J9 TREES-STRUCT FUNCT JI Trees-Struct. Funct. PD JUN PY 2014 VL 28 IS 3 BP 849 EP 858 DI 10.1007/s00468-014-0997-y PG 10 WC Forestry SC Forestry GA AH6VQ UT WOS:000336270400018 ER PT J AU Wang, ZL Mourelatos, ZP Li, J Baseski, I Singh, A AF Wang, Zhonglai Mourelatos, Zissimos P. Li, Jing Baseski, Igor Singh, Amandeep TI Time-Dependent Reliability of Dynamic Systems Using Subset Simulation With Splitting Over a Series of Correlated Time Intervals SO JOURNAL OF MECHANICAL DESIGN LA English DT Article ID HYDROKINETIC TURBINE-BLADES; STOCHASTIC EXCITATION; COMPONENTS; SUBJECT; DESIGN; MODELS AB Time-dependent reliability is the probability that a system will perform its intended function successfully for a specified time. Unless many and often unrealistic assumptions are made, the accuracy and efficiency of time-dependent reliability estimation are major issues which may limit its practicality. Monte Carlo simulation (MCS) is accurate and easy to use, but it is computationally prohibitive for high dimensional, long duration, time-dependent (dynamic) systems with a low failure probability. This work is relevant to systems with random parameters excited by stochastic processes. Their response is calculated by time integrating a set of differential equations at discrete times. The limit state functions are, therefore, explicit in time and depend on time-invariant random variables and time-dependent stochastic processes. We present an improved subset simulation with splitting approach by partitioning the original high dimensional random process into a series of correlated, short duration, low dimensional random processes. Subset simulation reduces the computational cost by introducing appropriate intermediate failure sub-domains to express the low failure probability as a product of larger conditional failure probabilities. Splitting is an efficient sampling method to estimate the conditional probabilities. The proposed subset simulation with splitting not only estimates the time-dependent probability of failure at a given time but also estimates the cumulative distribution function up to that time with approximately the same cost. A vibration example involving a vehicle on a stochastic road demonstrates the advantages of the proposed approach. C1 [Wang, Zhonglai] Univ Elect Sci & Technol China, Chengdu 611731, Sichuan, Peoples R China. [Mourelatos, Zissimos P.; Li, Jing] Oakland Univ, Dept Mech Engn, Rochester, MI 48309 USA. [Baseski, Igor; Singh, Amandeep] US Army TARDEC, Warren, MI 48397 USA. RP Mourelatos, ZP (reprint author), Oakland Univ, Dept Mech Engn, Rochester, MI 48309 USA. EM mourelat@oakland.edu FU Automotive Research Center (ARC), U.S. Army Tank Automotive Research, Development and Engineering Center (TARDEC) [W56HZV-04-2-0001] FX We would like to acknowledge the technical and financial support of the Automotive Research Center (ARC) in accordance with Cooperative Agreement No. W56HZV-04-2-0001 U.S. Army Tank Automotive Research, Development and Engineering Center (TARDEC). NR 35 TC 7 Z9 7 U1 0 U2 13 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 1050-0472 J9 J MECH DESIGN JI J. Mech. Des. PD JUN PY 2014 VL 136 IS 6 AR 061008 DI 10.1115/1.4027162 PG 12 WC Engineering, Mechanical SC Engineering GA AH2LO UT WOS:000335953200008 ER PT J AU Panchal, RG Mourich, DV Bradfute, S Hauck, LL Warfield, KL Iversen, PL Bavari, S AF Panchal, Rekha G. Mourich, Dan V. Bradfute, Steven Hauck, Laura L. Warfield, Kelly L. Iversen, Patrick L. Bavari, Sina TI Induced IL-10 Splice Altering Approach to Antiviral Drug Discovery SO NUCLEIC ACID THERAPEUTICS LA English DT Article ID EBOLA-VIRUS INFECTION; T-CELL RESPONSES; ANTISENSE OLIGOMERS; INTERLEUKIN-10; PROTECTION; APOPTOSIS; CYTOKINE AB Ebola virus causes an acute hemorrhagic fever lethal in primates and rodents. The contribution of host immune factors to pathogenesis has yet to be determined and may reveal efficacious targets for potential treatment. In this study, we show that the interleukin (IL)-10 signaling pathway modulates Ebola pathogenesis. IL-10(-/-) mice and wild-type mice receiving antisense targeting IL-10 signaling via disrupting expression through aberrant splice altering were resistant to ebola virus infection. IL-10(-/-) mice exhibited reduced viral titers, pathology, and levels of IL-2, IL-6, keratinocyte-derived chemokine (KC), and macrophage inflammatory protein-1 alpha and increased interferon (IFN)-gamma relative to infected wild-type mice. Furthermore, antibody depletion studies in IL-10(-/-) mice suggest a requirement for natural killer cells and IFN-gamma for protection. Together, these data demonstrate that resistance to ebola infection is regulated by IL-10 and can be targeted in a prophylactic manner to protect against lethal hemorrhagic virus challenge. C1 [Panchal, Rekha G.; Bradfute, Steven; Warfield, Kelly L.; Bavari, Sina] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. [Mourich, Dan V.; Hauck, Laura L.; Iversen, Patrick L.] Sarepta Therapeut Inc, Corvallis, OR USA. [Mourich, Dan V.; Hauck, Laura L.; Iversen, Patrick L.] Oregon State Univ, Corvallis, OR 97331 USA. RP Mourich, DV (reprint author), Sarepta Therapeut, 4575 Southwest Res Way,Suite 200, Corvallis, OR 97333 USA. EM Dmourich@Sarepta.com FU Postgraduate Research Participation Program at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRID); U.S. Department of Energy; U.S. Army Medical Research and Materiel Command (USAMRMC); Joint Project Manager-Transformational Medical Technologies Initiative [HDTRA1-07-C-0010] FX Support from Postgraduate Research Participation Program at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRID) administered by the Oak Ridge Institute for Science and Education and the U.S. Department of Energy and the U.S. Army Medical Research and Materiel Command (USAMRMC). We thank Jay Wells, Sean Van Tongeren, Kelly Donner, Christine Mech, Jeff Brubaker, and Shannon Oda for expert technical assistance. This work was supported by multiple contracts to Sarepta Therapeutics, Inc. by the Joint Project Manager-Transformational Medical Technologies Initiative (HDTRA1-07-C-0010). Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. NR 19 TC 4 Z9 5 U1 0 U2 22 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 2159-3337 EI 2159-3345 J9 NUCLEIC ACID THER JI Nucl. Acid Ther. PD JUN 1 PY 2014 VL 24 IS 3 BP 179 EP 185 DI 10.1089/nat.2013.0457 PG 7 WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Medicine, Research & Experimental SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Research & Experimental Medicine GA AH2OJ UT WOS:000335960500001 PM 24655055 ER PT J AU Little, DM Geary, EK Moynihan, M Alexander, A Pennington, M Glang, P Schulze, ET Dretsch, M Pacifico, A Davis, ML Stevens, AB Huang, JH AF Little, Deborah M. Geary, Elizabeth K. Moynihan, Michael Alexander, Aristides Pennington, Michelle Glang, Patrick Schulze, Evan T. Dretsch, Michael Pacifico, Anthony Davis, Matthew L. Stevens, Alan B. Huang, Jason H. TI Imaging chronic traumatic brain injury as a risk factor for neurodegeneration SO ALZHEIMERS & DEMENTIA LA English DT Article DE Traumatic brain injury; Repetitive TBI; Dementia; Neuroimaging ID MINI-MENTAL-STATE; INTEGRITY AB Population-based studies have supported the hypothesis that a positive history of traumatic brain injury (TBI) is associated with an increased incidence of neurological disease and psychiatric comorbidities, including chronic traumatic encephalopathy, Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. These epidemiologic studies, however, do not offer a clear definition of that risk, and leave unanswered the bounding criteria for greater lifetime risk of neurodegeneration. Key factors that likely mediate the degree of risk of neurodegeneration include genetic factors, significant premorbid and comorbid medical history (e.g. depression, multiple head injuries and repetitive subconcussive impact to the brain, occupational risk, age at injury, and severity of brain injury). However, given the often-described concerns in self-report accuracy as it relates to history of multiple TBIs, low frequency of patient presentation to a physician in the case of mild brain injuries, and challenges with creating clear distinctions between injury severities, disentangling the true risk for neurodegeneration based solely on population-based studies will likely remain elusive. Given this reality, multiple modalities and approaches must be combined to characterize who are at risk so that appropriate interventions to alter progression of neurodegeneration can be evaluated. This article presents data from a study that highlights uses of neuro-imaging and areas of needed research in the link between TBI and neurodegenerative disease. (C) 2014 Published by Elsevier Inc. on behalf of The Alzheimer's Association. C1 [Little, Deborah M.; Pennington, Michelle; Davis, Matthew L.; Stevens, Alan B.; Huang, Jason H.] BaylorScott & White Hlth, Temple, TX 75201 USA. [Little, Deborah M.; Davis, Matthew L.; Stevens, Alan B.; Huang, Jason H.] Texas A&M Univ Hlth Sci, Temple, TX USA. [Geary, Elizabeth K.] Northshore Hlth Syst, Evanston, IL USA. [Moynihan, Michael] West Virginia Sch Osteopath Med, Lewisburg, WV USA. [Alexander, Aristides] Advocate Christ Med Ctr, Chicago, IL USA. [Glang, Patrick] Univ Oregon, Eugene, OR 97403 USA. [Schulze, Evan T.] St Louis Univ, St Louis, MO 63103 USA. [Dretsch, Michael] Walter Reed Natl Mil Med Ctr, Natl Intrepid Ctr Excellence, Bethesda, MD USA. [Pacifico, Anthony] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA. RP Little, DM (reprint author), BaylorScott & White Hlth, Temple, TX 75201 USA. EM deborahmlittle@gmail.com FU Department of Defense/Congressionally Directed Medical Research Program [PT 075675]; Marshall Goldberg Traumatic Brain Injury Fund; Chicago Institute for Neurosurgery and Neuroresearch Foundation FX This work is supported in part by a Department of Defense/Congressionally Directed Medical Research Program grant (PT 075675 to DML), the Marshall Goldberg Traumatic Brain Injury Fund (to DML), and a grant from the Chicago Institute for Neurosurgery and Neuroresearch Foundation (to DML). The contents of this article are the sole responsibility of the authors and do not necessarily represent the official views of the University of Illinois at Chicago, Baylor Scott & White Health, Texas A&M University Health Sciences, the U.S. Department of the Army, the Department of Defense, or the National Institutes of Health. NR 25 TC 5 Z9 6 U1 1 U2 9 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1552-5260 EI 1552-5279 J9 ALZHEIMERS DEMENT JI Alzheimers. Dement. PD JUN PY 2014 VL 10 IS 3 SU 1 BP S188 EP S195 DI 10.1016/j.jalz.2014.04.002 PG 8 WC Clinical Neurology SC Neurosciences & Neurology GA CP8GM UT WOS:000360130700013 PM 24924670 ER PT J AU Weiner, MW Veitch, DP Hayes, J Neylan, T Grafman, J Aisen, PS Petersen, RC Jack, C Jagust, W Trojanowski, JQ Shaw, LM Saykin, AJ Green, RC Harvey, D Toga, AW Friedl, KE Pacifico, A Sheline, Y Yaffe, K Mohlenoff, B AF Weiner, Michael W. Veitch, Dallas P. Hayes, Jacqueline Neylan, Thomas Grafman, Jordan Aisen, Paul S. Petersen, Ronald C. Jack, Clifford Jagust, William Trojanowski, John Q. Shaw, Leslie M. Saykin, Andrew J. Green, Robert C. Harvey, Danielle Toga, Arthur W. Friedl, Karl E. Pacifico, Anthony Sheline, Yvette Yaffe, Kristine Mohlenoff, Brian CA Dept Def Alzheimer's Dis TI Effects of traumatic brain injury and posttraumatic stress disorder on Alzheimer's disease in veterans, using the Alzheimer's Disease Neuroimaging Initiative SO ALZHEIMERS & DEMENTIA LA English DT Article DE Traumatic brain injury; Posttraumatic stress disorder; Alzheimer's disease; Veterans; Neuroimaging ID AMYLOID PROTEIN DEPOSITION; MILD COGNITIVE IMPAIRMENT; ADDICTION SEVERITY INDEX; HEAD-INJURY; APOLIPOPROTEIN-E; CEREBROSPINAL-FLUID; BIOMARKER SIGNATURE; N-ACETYLASPARTATE; FLORBETAPIR F-18; TERM SURVIVORS AB Both traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD) are common problems resulting from military service, and both have been associated with increased risk of cognitive decline and dementia resulting from Alzheimer's disease (AD) or other causes. This study aims to use imaging techniques and biomarker analysis to determine whether traumatic brain injury (TBI) and/or PTSD resulting from combat or other traumas increase the risk for AD and decrease cognitive reserve in Veteran subjects, after accounting for age. Using military and Department of Veterans Affairs records, 65 Vietnam War veterans with a history of moderate or severe TBI with or without PTSD, 65 with ongoing PTSD without TBI, and 65 control subjects are being enrolled in this study at 19 sites. The study aims to select subject groups that are comparable in age, gender, ethnicity, and education. Subjects with mild cognitive impairment (MCI) or dementia are being excluded. However, a new study just beginning, and similar in size, will study subjects with TBI, subjects with PTSD, and control subjects with MCI. Baseline measurements of cognition, function, blood, and cerebrospinal fluid biomarkers; magnetic resonance images (structural, diffusion tensor, and resting state blood-level oxygen dependent (BOLD) functional magnetic resonance imaging); and amyloid positron emission tomographic (PET) images with florbetapir are being obtained. One-year follow-up measurements will be collected for most of the baseline procedures, with the exception of the lumbar puncture, the PET imaging, and apolipoprotein E genotyping. To date, 19 subjects with TBI only, 46 with PTSD only, and 15 with TBI and PTSD have been recruited and referred to 13 clinics to undergo the study protocol. It is expected that cohorts will be fully recruited by October 2014. This study is a first step toward the design and statistical powering of an AD prevention trial using at-risk veterans as subjects, and provides the basis for a larger, more comprehensive study of dementia risk factors in veterans. (C) 2014 Published by Elsevier Inc. on behalf of The Alzheimer's Association. C1 [Weiner, Michael W.; Veitch, Dallas P.; Hayes, Jacqueline] Ctr Imaging Neurodegenerat Dis, Dept Vet Affairs Med Ctr, San Francisco, CA 94143 USA. [Weiner, Michael W.] Univ Calif San Francisco, Dept Radiol, San Francisco, CA USA. [Weiner, Michael W.] Univ Calif San Francisco, Dept Med, San Francisco, CA USA. [Weiner, Michael W.; Neylan, Thomas; Yaffe, Kristine; Mohlenoff, Brian] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA. [Weiner, Michael W.; Yaffe, Kristine] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA. [Grafman, Jordan] Northwestern Univ, Feinberg Sch Med, Dept Psychiat, Chicago, IL 60611 USA. [Aisen, Paul S.] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA. [Petersen, Ronald C.] Mayo Clin, Dept Neurol, Rochester, MN USA. [Jack, Clifford] Mayo Clin, Dept Radiol, Rochester, MN USA. [Jagust, William] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA. [Trojanowski, John Q.] Univ Penn, Perelman Sch Med, Inst Aging, Philadelphia, PA 19104 USA. [Trojanowski, John Q.] Univ Penn, Perelman Sch Med, Alzheimers Dis Core Ctr, Philadelphia, PA 19104 USA. [Trojanowski, John Q.] Univ Penn, Perelman Sch Med, Udall Parkinsons Res Ctr, Philadelphia, PA 19104 USA. [Trojanowski, John Q.] Univ Penn, Perelman Sch Med, Ctr Neurodegenerat Res, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA. [Shaw, Leslie M.] Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA. [Saykin, Andrew J.] Indiana Univ, Sch Med, Dept Radiol & Imaging Sci, Indianapolis, IN USA. [Saykin, Andrew J.] Indiana Univ, Sch Med, Dept Med & Mol Genet, Indianapolis, IN 46202 USA. [Green, Robert C.] Brigham & Womens Hosp, Dept Med, Div Genet, Boston, MA 02115 USA. [Green, Robert C.] Harvard Univ, Sch Med, Boston, MA USA. [Harvey, Danielle] Univ Calif Davis, Dept Publ Hlth Sci, Div Biostat, Davis, CA 95616 USA. [Toga, Arthur W.] Univ So Calif, Inst Neuroimaging & Informat, Lab Neuroimaging, Los Angeles, CA USA. [Pacifico, Anthony] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA. [Sheline, Yvette] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA. RP Weiner, MW (reprint author), Ctr Imaging Neurodegenerat Dis, Dept Vet Affairs Med Ctr, San Francisco, CA 94143 USA. EM michael.weiner@ucsf.edu RI Jack, Clifford/F-2508-2010 OI Jack, Clifford/0000-0001-7916-622X FU National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; DOD [W81XWH-12-2-0012] FX ADNI is funded by the National Institute on Aging and National Institute of Biomedical Imaging and Bioengineering, and through generous contributions from the following: Alzheimer's Association; Alzheimer's Drug Discovery Foundation; Avid Radiopharmaceuticals, Inc; BioClinica, Inc.; Biogen Idec Inc.; Bristol-Myers Squibb Company; Eisai Inc.; Elan Pharmaceuticals, Inc.; Eli Lilly and Company; F. Hoffmann-La Roche Ltd and its affiliated company Genentech, Inc.; GE Healthcare; Innogenetics, N.V.; IXICO Ltd.; Janssen Alzheimer Immunotherapy Research & Development, LLC; Johnson & Johnson Pharmaceutical Research & Development LLC; Medpace, Inc.; Merck & Co., Inc.; Meso Scale Diagnostics, LLC.; NeuroRx Research; Novartis Pharmaceuticals Corporation; Pfizer Inc.; Piramal Imaging; Servier; Synarc Inc.; and Takeda Pharmaceutical Company. The Canadian Institutes of Health Research is providing funds to support ADNI clinical sites in Canada. Private-sector contributions are facilitated by the Foundation for the National Institutes of Health (www.fnih.org). The grantee organization for ADNI is the Northern California Institute for Research and Education, and the study is coordinated by the Alzheimer's Disease Cooperative Study at the University of California, San Diego. ADNI DOD data are disseminated by the Laboratory for Neuro Imaging at the University of California, Los Angeles. We thank all the veterans for their generous participation in this ADNI DOD study. This research was also supported by DOD award number W81XWH-12-2-0012. NR 114 TC 12 Z9 12 U1 4 U2 13 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1552-5260 EI 1552-5279 J9 ALZHEIMERS DEMENT JI Alzheimers. Dement. PD JUN PY 2014 VL 10 IS 3 SU 1 BP S226 EP S235 DI 10.1016/j.jalz.2014.04.005 PG 10 WC Clinical Neurology SC Neurosciences & Neurology GA CP8GM UT WOS:000360130700016 PM 24924673 ER PT J AU Matheny, RW AF Matheny, Ronald Wayne TI Skeletal Muscle-Specific Deletion of p110beta Reduces Skeletal Muscle Mass and Strength in Mice SO ENDOCRINE REVIEWS LA English DT Meeting Abstract C1 [Matheny, Ronald Wayne] US Army, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0163-769X EI 1945-7189 J9 ENDOCR REV JI Endocr. Rev. PD JUN PY 2014 VL 35 IS 3 SU S MA MON-0345 PG 2 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA V45GM UT WOS:000209805100252 ER PT J AU Riddle, MA Leandry, LA Matheny, RW AF Riddle, Melissa A. Leandry, Luis Angel Matheny, Ronald Wayne TI Pharmacological Inhibition of PI3K p110beta Suppresses Myoblast Differentiation SO ENDOCRINE REVIEWS LA English DT Meeting Abstract C1 [Riddle, Melissa A.; Leandry, Luis Angel; Matheny, Ronald Wayne] US Army, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0163-769X EI 1945-7189 J9 ENDOCR REV JI Endocr. Rev. PD JUN PY 2014 VL 35 IS 3 SU S MA SUN-0361 PG 2 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA V45GM UT WOS:000209805100250 ER PT J AU Truong, Q Pomerantz, N Yip, P Sieber, M Mabry, JM Ramirez, SM AF Quoc Truong Pomerantz, Natalie Yip, Pearl Sieber, Michael Mabry, Joseph M. Ramirez, Sean M. TI Pilot-scale coating of fabrics with fluorodecyl polyhedral oligomeric silsesquioxane/fluoroelastomer blends SO SURFACE INNOVATIONS LA English DT Article DE coating; contact angle; oleophobic; self-cleaning; superhydrophobic; surface energy ID INTERFACIAL ENERGIES; SURFACES AB A durable, conformal coating was developed based on the use of very low surface tension fluorodecyl polyhedral oligomeric silsesquioxane (Fluoro-POSS) cage-like molecule and a fluorinated elastomer. When this coating is applied, the resulting oleophobic fabrics resist surface wetting by a wide range of liquids having high to very low surface tension values, while remaining durable after repeated washing and abrasion testing. Collected data indicated minimal interference to air flow and moisture vapor through the conformally coated textiles. While textiles having said repellent treatment have been prepared previously by dip and spray coating in non-continuous laboratory applications, in 2012 the US Army Natick Research Development and Engineering Center successfully demonstrated a continuous, scalable application of Fluoro-POSS-treated textiles by way of a 24-inch-wide pad/dry/cure treatment. Material syntheses will be reported, and coating solution preparation and pilot-scale coating parameters will be discussed. Comparative data on surface, chemical and physical properties of lab-scale against pilot-scale coated repellent treated fabrics will be presented. These will include measurement of oleophobic coated fabrics' contact angle using various liquids such as water and hazardous chemicals, as well as evaluation of chemical permeation test results and physical properties. Future work will examine the effects of different concentrations of low surface tension fluoropolymers and elastomers, hierarchical re-entrant nanostructures, and optimal processing and curing conditions. C1 [Quoc Truong] US Army, Dept Plast Engn, NSRDEC, Natick, MA 01760 USA. [Quoc Truong] US Army, Dept Engn Management, NSRDEC, Natick, MA 01760 USA. [Pomerantz, Natalie] US Army, Dept Chem Engn, NSRDEC, Natick, MA 01760 USA. [Yip, Pearl] US Army, Dept Chem, NSRDEC, Natick, MA 01760 USA. [Sieber, Michael] Oak Ridge Inst Sci & Educ, Dept Text Engn, Oak Ridge, TN USA. [Mabry, Joseph M.] Air Force Res Lab, Aerosp Syst Directorate, Dept Polymer Chem, Edwards AFB, CA USA. [Ramirez, Sean M.] Air Force Res Lab, ERC Inc, Dept Polymer Chem, Edwards AFB, CA USA. RP Truong, Q (reprint author), US Army, Dept Plast Engn, NSRDEC, Natick, MA 01760 USA. EM quoc.t.truong.civ@mail.mil FU US Defense Threat Reduction Agency; Joint Science & Technology Office for Chemical and Biological Defense as part of the Integrated Protective Fabric Systems program [W911NF07D0004]; US Department of Energy; NSRDEC FX This work was funded by the US Defense Threat Reduction Agency and Joint Science & Technology Office for Chemical and Biological Defense as part of the Integrated Protective Fabric Systems program (via ARO Contract with ISN, contract W911NF07D0004). This work was supported in part by an appointment to the Postgraduate Research Participant Program administered by the Oak Ridge Institute for Science and Education's Research Participant Program through an interagency agreement between the US Department of Energy and NSRDEC. All textile testing were conducted by NSRDEC Textile Materials Testing Laboratory. Special thanks go to Drs Robert Cohen and Gareth McKinley from MIT, who provided treated samples and insight related to developing superoleophobic surfaces to the NSRDEC team; Mr Bill DiIanni and Mr Dale Arnold from International Textile Group/Burlington Laboratory, who provided the ITG nylon fabric Style 1194, which was used in this pilot scale up coating study, other ITG nylon and polyester fabrics, and their insights related to their fabric properties. NR 19 TC 2 Z9 2 U1 2 U2 6 PU ICE PUBLISHING PI WESTMINISTER PA INST CIVIL ENGINEERS, 1 GREAT GEORGE ST, WESTMINISTER SW 1P 3AA, ENGLAND SN 2050-6252 EI 2050-6260 J9 SURF INNOV JI Surf. Innov. PD JUN PY 2014 VL 2 IS 2 BP 79 EP 93 DI 10.1680/si.13.00049 PG 15 WC Chemistry, Physical; Materials Science, Coatings & Films SC Chemistry; Materials Science GA CZ3AT UT WOS:000366977100003 ER PT J AU Casem, DT Dwivedi, AK Mrozek, RA Lenhart, JL AF Casem, Daniel T. Dwivedi, Ajmer K. Mrozek, Randy A. Lenhart, Joseph L. TI Compression response of a thermoplastic elastomer gel tissue surrogate over a range of strain-rates SO INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES LA English DT Article DE Kolsky bar; Split Hopkinson pressure bar; High-rate testing; Ballistic gelatin ID HOPKINSON PRESSURE BAR; DEFORMATION; BEHAVIOR; INERTIA; COPPER AB The mechanical response of a thermoplastic elastomer synthetic ballistic gel is studied over a range of strain-rates. Experiments were conducted at room temperature under uniaxial stress compression at rates ranging from 0.001 to 500/s. Low-rate experiments (< 1/s) were conducted with a servo-hydraulic load frame. High-rate experiments (> 100/s) were conducted with a polymeric Kolsky bar, along with several modifications to improve data quality. These modifications include the use of a commercial force transducer, a normal displacement interferometer, and a line laser extensometer. Because of the low shear strength and comparatively high compressibility of these materials, inertial effects are very pronounced. Specimen size is varied in an effort to study inertial effects at various loading rates. High speed photography is also used to demonstrate the presence of non-uniform deformation, due to both inertia and friction between the specimen and the loading surfaces. Finally, numerical simulation is used to verify trends observed in the experiments and further validate the data. It is concluded that this material is rate sensitive, with an almost three-fold increase in stiffness over the range of strain-rates studied. Published by Elsevier Ltd. C1 [Casem, Daniel T.] US Army, Res Lab, RDRL WMP C, Aberdeen Proving Ground, MD 21005 USA. [Dwivedi, Ajmer K.] Dynamic Sci Inc, RDRL WMP B, Aberdeen Proving Ground, MD 21005 USA. [Mrozek, Randy A.; Lenhart, Joseph L.] US Army, Res Lab, RDRL WMM G, Aberdeen Proving Ground, MD 21005 USA. RP Casem, DT (reprint author), US Army, Res Lab, RDRL WMP C, Aberdeen Proving Ground, MD 21005 USA. EM daniel.t.casem.civ@mail.mil NR 34 TC 1 Z9 1 U1 1 U2 29 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0020-7683 EI 1879-2146 J9 INT J SOLIDS STRUCT JI Int. J. Solids Struct. PD JUN 1 PY 2014 VL 51 IS 11-12 BP 2037 EP 2046 DI 10.1016/j.ijsolstr.2013.12.028 PG 10 WC Mechanics SC Mechanics GA AG2UH UT WOS:000335272100001 ER PT J AU Bays, H Cohen, DE Chalasani, N Harrison, SA AF Bays, Harold Cohen, David E. Chalasani, Naga Harrison, Stephen A. TI An assessment by the Statin Liver Safety Task Force: 2014 update SO JOURNAL OF CLINICAL LIPIDOLOGY LA English DT Article DE Cholesterol; National Lipid; Association; Lipid; Liver; Statin ID NONALCOHOLIC STEATOHEPATITIS; CARDIOVASCULAR EVENTS; DISEASE; DYSLIPIDEMIA; ATORVASTATIN; CONSENSUS; INJURY; TRIAL AB In the 2006 Report of the National Lipid Association's Statin Safety Task Force, a panel of experts in hepatology published their findings on specific questions related to the liver blood testing during statin therapy. Among their recommendations was that regulatory agencies reconsider the statin-labeling recommendation at that time, which required post-statin liver enzyme testing. Since then, the Food and Drug Administration altered statin labeling such that unless clinically indicated for other reasons, after a pre-statin therapy baseline evaluation, follow-up liver enzyme testing was not uniformly required after statin initiation. This 2014 report provides an update on interim issues relevant to statins and liver safety. Some of the points discussed include the value of baseline liver enzymes before initiating statin therapy, safety of statin use in patients with nonalcoholic fatty liver disease, potential drug interactions between statins and drugs used to treat hepatitis, the use of statins in liver transplant recipients, and the use of statins in patients with autoimmune liver disease. Finally, this panel provides diagnostic and algorithmic approaches when evaluating statin-treated patients who experience elevations in liver enzymes. (C) 2014 National Lipid Association. All rights reserved. C1 [Bays, Harold] Louisville Metab & Atherosclerosis Res Ctr, Louisville, KY 40213 USA. [Cohen, David E.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA. [Chalasani, Naga] Indiana Univ Sch Med, Indianapolis, IN 46202 USA. [Harrison, Stephen A.] Uniformed Serv Univ Hlth Sci, Univ Texas Hlth Ctr San Antonio, Brooke Army Med Ctr, San Antonio, TX USA. RP Bays, H (reprint author), Louisville Metab & Atherosclerosis Res Ctr, 3288 Illinois Ave, Louisville, KY 40213 USA. EM hbaysmd@aol.com FU Alere; Amarin; Amgen; Ardea; Astra Zeneca; Boehringer Ingelheim; Bristol-Myers Squibb; California Raisin Board; Catabasis; Eisai; Elcelyx; Eli Lilly; Esperion; High Point Pharmaceuticals LLC; Micropharma Limited FX In the past 12 months, Dr. Harold Bays has served as a consultant and/or speaker to Amarin, Amgen, Astra Zeneca, Bristol Meyers Squibb, Catabasis, Daiichi Sankyo, Eisai, Isis, Merck, Novartis, VIVUS, WPU, and his research site has received research grants from Alere, Amarin, Amgen, Ardea, Astra Zeneca, Boehringer Ingelheim, Bristol-Myers Squibb, California Raisin Board, Catabasis, Eisai, Elcelyx, Eli Lilly, Esperion, Essentialis, Forest, Gilead, Given, GlaxoSmithKline, High Point Pharmaceuticals LLC, Hoffman LaRoche, Home Access, Janssen, Merck, Metabolex, Micropharma Limited, Necktar, Novartis, Novo Nordisk, Omthera, Orexigen, Pfizer, Pronova, Regeneron, Stratum Nutrition, Takeda, TIMI, Transtech Pharma, Trygg, VIVUS, WPU, and Xoma. Dr. David Cohen reports having received consulting fees from Merck, Aegerion, Dignity Sciences, Genzyme, and Novartis, and has additionally received honoraria from Merck. Dr. Naga Chalasani reports serving as a consultant to Aegerion, Salix, and Lilly; is on the Data and Safety Monitoring Boards of AbbVie and Merck; and his institution has received research grants from Gilead, Intercept, Cumberland, and Enterome. Dr. Stephen Harrison discloses he has received consulting fees/honoraria from Merck, Vertex, and the Chronic Liver Disease Foundation; consulting fees from Nimbus and Genentech; and honoraria from the American Association for Study of Liver Diseases. NR 24 TC 44 Z9 50 U1 2 U2 10 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1933-2874 EI 1876-4789 J9 J CLIN LIPIDOL JI J. Clin. Lipidol. PD JUN PY 2014 VL 8 IS 3 SU S BP S47 EP S57 DI 10.1016/j.jacl.2014.02.011 PG 11 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA AG2YZ UT WOS:000335284300005 PM 24793441 ER PT J AU Petrie, JR Wieland, KA Burke, RA Newburgh, GA Burnette, JE Fischer, GA Edelstein, AS AF Petrie, J. R. Wieland, K. A. Burke, R. A. Newburgh, G. A. Burnette, J. E. Fischer, G. A. Edelstein, A. S. TI A non-erasable magnetic memory based on the magnetic permeability SO JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS LA English DT Article DE Magnetic; Memory; Permeability; Non-erasable; Thermal ID INTERFERENCE AB A non-erasable memory based on using differences in the magnetic permeability is demonstrated. The method can potentially store information indefinitely. Initially the high permeability bits were 10-50 mu m wide lines of sputtered permalloy (Ni81Fe19) on a glass substrate. In a second writing technique a continuous film of amorphous, high permeability ferromagnetic Metglas (Fe78Si13B9) was sputtered onto a similar glass substrate. Low permeability, crystalline 50 mu m wide lines were then written in the film by laser heating. Both types of written media were read by applying an external probe field that is locally modified by the permeability of each bit. The modifications in the probe field were read by a nearby set of 10 micron wide magnetic tunnel junctions with a signal-to-noise ratio of up to 45 dB. This large response to changes in bit permeability is not altered after the media has been exposed to a 6400 Oe field. While being immediately applicable for data archiving and secure information storage, higher densities are possible with smaller read and write heads. Published by Elsevier B.V. C1 [Petrie, J. R.; Wieland, K. A.; Burke, R. A.; Newburgh, G. A.; Fischer, G. A.; Edelstein, A. S.] US Army Res Lab, Adelphi, MD 20783 USA. [Burnette, J. E.] Spin Transfer Technol, Boston, MA USA. RP Edelstein, AS (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM alan.s.edelstein.civ@us.army.mil NR 27 TC 3 Z9 3 U1 1 U2 32 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-8853 EI 1873-4766 J9 J MAGN MAGN MATER JI J. Magn. Magn. Mater. PD JUN PY 2014 VL 361 BP 262 EP 266 DI 10.1016/j.jmmm.2014.01.018 PG 5 WC Materials Science, Multidisciplinary; Physics, Condensed Matter SC Materials Science; Physics GA AE9OB UT WOS:000334336000043 ER PT J AU Fullerton, RJ Cole, DP Behler, KD Das, S Irin, F Parviz, D Hoque, MNF Fan, ZY Green, MJ AF Fullerton, Robert J. Cole, Daniel P. Behler, Kristopher D. Das, Sriya Irin, Fahmida Parviz, Dorsa Hoque, M. N. F. Fan, Zhaoyang Green, Micah J. TI Graphene non-covalently tethered with magnetic nanoparticles SO CARBON LA English DT Article ID CARBON NANOTUBES; OXIDE; COMPOSITES AB We describe a novel approach for coupling pristine graphene with superparamagnetic iron oxide nanoparticles to create dispersed, magnetically responsive hybrids. The magnetic iron oxide (Fe3O4) nanoparticles are synthesized by a co-precipitation method using ferric (Fe3+) and ferrous (Fe2+) salts and then grafted with polyvinylpyrrolidone (PVP). These PVP-grafted Fe3O4 nanoparticles are then used to stabilize colloidal graphene in water. The PVP branches non-covalently attach to the surface of the pristine graphene sheets without functionalization or defect creation. These Fe3O4-graphene hybrids are stable against aggregation and are highly responsive to external magnetic fields. These hybrids can be freeze-dried to a powder or magnetically separated from solution and still easily redisperse while retaining magnetic functionality. At all stages of synthesis, the Fe3O4-graphene hybrids display no coercivity after being brought to magnetic saturation, confirming superparamagnetic properties. Microscopy and light scattering data confirm the presence of pristine graphene sheets decorated with Fe3O4 nanoparticles. These materials show promise for multifunctional polymer composites as well as biomedical applications and environmental remediation. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Fullerton, Robert J.; Das, Sriya; Irin, Fahmida; Parviz, Dorsa; Green, Micah J.] Texas Tech Univ, Dept Chem Engn, Lubbock, TX 79409 USA. [Hoque, M. N. F.; Fan, Zhaoyang] Texas Tech Univ, Dept Elect & Comp Engn, Lubbock, TX 79409 USA. [Cole, Daniel P.] Motile Robot Inc, Joppa, MD USA. [Behler, Kristopher D.] US Army, Res Lab, RDRL WMM E, Ceram & Transparent Mat Branch, Aberdeen Proving Ground, MD USA. [Behler, Kristopher D.] Bowhead Sci & Technol, Belcamp, MD USA. RP Green, MJ (reprint author), Texas Tech Univ, Dept Chem Engn, Lubbock, TX 79409 USA. EM micah.green@ttu.edu RI Hoque, Md Nadim Ferdous/K-2884-2013; Green, Micah/C-7647-2011 OI Hoque, Md Nadim Ferdous/0000-0002-0662-6915; Green, Micah/0000-0001-5691-0861 FU U.S. National Science Foundation (NSF) [CMMI-1253085]; Air Force Office of Scientific Research Young Investigator Program [AFOSR FA9550-11-1-0027]; TTU Center for Undergraduate Research; NSF [MRI 04-511]; ARL-BST Program FX The authors would like to acknowledge Rozana Bari, Shane Metzler, Dr. Weile Yan, Dr. Sanjoy K. Bhattacharia, Dr. Brandon L. Weeks, and Dr. Ronald Hedden of TTU for helpful insight as well as N. Arsalani and H. Fattahi of the University of Tabriz for synthesis advice. Funding was provided by the U.S. National Science Foundation (NSF) under CAREER award CMMI-1253085 and by the Air Force Office of Scientific Research Young Investigator Program (AFOSR FA9550-11-1-0027), and by the TTU Center for Undergraduate Research. DLS measurements were conducted in the Materials Characterization Center with the support of Dr. Juliusz Warzywoda and Dr. Al Sacco of TTU. We also acknowledge the TTU Imaging Center (funded by NSF MRI 04-511) supported by Professor Lauren S. Gollahon for the HRTEM images. Dr. K. Behler is a Bowhead Science and Technology (BST) Senior Scientist at ARL, and he gratefully acknowledges support from the ARL-BST Program. NR 19 TC 6 Z9 6 U1 3 U2 99 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0008-6223 EI 1873-3891 J9 CARBON JI Carbon PD JUN PY 2014 VL 72 BP 192 EP 199 DI 10.1016/j.carbon.2014.02.002 PG 8 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA AE5EM UT WOS:000334010600022 ER PT J AU Quraishi, Q Diddams, SA Hollberg, L AF Quraishi, Qudsia Diddams, Scott A. Hollberg, Leo TI Optical phase-noise dynamics of Titanium:sapphire optical frequency combs SO OPTICS COMMUNICATIONS LA English DT Article DE Ultrafast; Phase noise; Optical reference; Frequency comb equation ID METROLOGY; TERAHERTZ; OFFSET; LINK; ION AB Stabilized optical frequency combs (OFC) can have remarkable levels of coherence across their broad spectral bandwidth. We study the scaling of the optical noise across hundreds of nanometers of optical spectra. We measure the residual phase noise between two OFC's (having offset frequencies f(0)((1)) and f(0)((2)) referenced to a common cavity-stabilized narrow linewidth CW laser. Their relative offset frequency Delta f(0) = f(0)((2))-f(0)((1)), which appears across their entire spectra, provides a convenient measure of the phase noise. By comparing Delta f(0) at different spectral regions, we demonstrate that the observed scaling of the residual phase noise is in very good agreement with the noise predicted from the standard frequency comb equation. (C) 2014 Published by Elsevier B.V. C1 [Quraishi, Qudsia] Army Res Lab, Adelphi, MD 20783 USA. [Diddams, Scott A.] Natl Inst Stand & Technol, Boulder, CO 80305 USA. [Hollberg, Leo] Stanford Univ, Dept Phys, Stanford, CA 94305 USA. RP Quraishi, Q (reprint author), Army Res Lab, Adelphi, MD 20783 USA. EM qudsia.quraishi@gmail.com NR 20 TC 0 Z9 0 U1 2 U2 34 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0030-4018 EI 1873-0310 J9 OPT COMMUN JI Opt. Commun. PD JUN 1 PY 2014 VL 320 BP 84 EP 87 DI 10.1016/j.optcom.2014.01.030 PG 4 WC Optics SC Optics GA AE2GM UT WOS:000333791300015 ER PT J AU Ramirez, A Arguello, H Arce, GR Sadler, BM AF Ramirez, Ana Arguello, Henry Arce, Gonzalo R. Sadler, Brian M. TI Spectral Image Classification From Optimal Coded-Aperture Compressive Measurements SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE Classification; coded aperture; coded-aperture snapshot spectral imaging (CASSI); hyperspectral imagery; principal component analysis (PCA); restricted isometry property (RIP); sparsity ID PRINCIPAL COMPONENT ANALYSIS; NEAREST-NEIGHBOR; PROJECTION; RECONSTRUCTION; RECOVERY AB Traditional hyperspectral imaging sensors acquire high-dimensional data that are used for the discrimination of objects and features in a scene. Recently, a novel architecture known as the coded-aperture snapshot spectral imaging (CASSI) system has been developed for the acquisition of compressive spectral image data with just a few coded focal plane array measurements. This paper focuses on developing a classification approach with hyperspectral images directly from CASSI compressive measurements, without first reconstructing the full data cube. The proposed classification method uses the compressive measurements to find the sparse vector representation of the test pixel in a given training dictionary. The estimated sparse vector is obtained by solving a sparsity-constrained optimization problem and is then used to directly determine the class of the unknown pixel. The performance of the proposed classifier is improved by taking optimal CASSI compressive measurements obtained when optimal coded apertures are used in the optical system. The set of optimal coded apertures is designed such that the CASSI sensing matrix satisfies a restricted isometry property with high probability. Several simulations illustrate the performance of the proposed classifier using optimal coded apertures and the gain in the classification accuracy obtained over using traditional aperture codes in CASSI. C1 [Ramirez, Ana; Arguello, Henry; Arce, Gonzalo R.] Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA. [Sadler, Brian M.] US Army Res Lab, Adelphi, MD 20783 USA. RP Ramirez, A (reprint author), Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA. FU Army Research Laboratory; Army Research Office [W911NF-11-1-0368]; National Science Foundation [EECS-0725422, CCF-0915800]; Office of Naval Research [NOOO14-1O-C-0199] FX Manuscript received November 5, 2012; revised March 24, 2013; accepted June 28, 2013. This work was supported in part by the Army Research Laboratory and the Army Research Office under Grant W911NF-11-1-0368 and in part by the National Science Foundation under Grants EECS-0725422 and CCF-0915800 and partially by the Office of Naval Research under Contract NOOO14-1O-C-0199. NR 32 TC 7 Z9 10 U1 2 U2 20 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0196-2892 EI 1558-0644 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD JUN PY 2014 VL 52 IS 6 BP 3299 EP 3309 DI 10.1109/TGRS.2013.2272378 PG 11 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA AC4QB UT WOS:000332504700022 ER PT J AU El Bissati, K Zhou, Y Dasgupta, D Cobb, D Dubey, JP Burkhard, P Lanar, DE McLeod, R AF El Bissati, Kamal Zhou, Ying Dasgupta, Debleena Cobb, Drew Dubey, Jitender P. Burkhard, Peter Lanar, David E. McLeod, Rima TI Effectiveness of a novel immunogenic nanoparticle platform for Toxoplasma peptide vaccine in HLA transgenic mice SO VACCINE LA English DT Article DE Toxoplasma gondii; HLA-B7; Vaccine; Nanoparticles ID IFN-GAMMA; CONGENITAL TOXOPLASMOSIS; PROTECTIVE IMMUNITY; DENDRITIC CELLS; GONDII; EXPRESSION; RESISTANCE; RESPONSES; GRA7; INFECTION AB We created and produced a novel self-assembling nanoparticle platform for delivery of peptide epitopes that induces CD8(+) and CD4(+)T cells that are protective against Toxoplasma gondii infection. These selfassembling polypeptide nanoparticles (SAPNs) are composed of linear peptide (LP) monomers which contain two coiled-coil oligomerization domains, the dense granule 7 (GRA7(20-28) LPQFATAAT) peptide and a universal CD4(+)T cell epitope (derived from PADRE). Purified LPs assemble into nanoparticles with icosahedral symmetry, similar to the capsids of small viruses. These particles were evaluated for their efficacy in eliciting IFN-gamma by splenocytes of HLA-B(*)0702 transgenic mice and for their ability to protect against subsequent T. gondii challenge. This work demonstrates the feasibility of using this platform approach with a CD8(+) epitope that binds HLA-B7 and tests the biological activity of potentially protective peptides restricted by human major histocompatibility complex (HLA) class I molecules in HLA transgenic mice. (C) 2014 Elsevier Ltd. All rights reserved. C1 [El Bissati, Kamal; Zhou, Ying; McLeod, Rima] Univ Chicago, Dept Surg, Chicago, IL 60637 USA. [Dasgupta, Debleena; Lanar, David E.] Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD 20910 USA. [Cobb, Drew] George Washington Univ, Washington, DC 20037 USA. [Dubey, Jitender P.] ARS, USDA, Beltsville Agr Res Ctr, Anim Parasit Dis Lab, Beltsville, MD 20705 USA. [Burkhard, Peter] Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA. [Burkhard, Peter] Univ Connecticut, Dept Mol & Cell Biol, Storrs, CT 06269 USA. RP El Bissati, K (reprint author), Univ Chicago, Dept Surg, 5841 S Maryland Ave, Chicago, IL 60637 USA. EM kelbissati@uchicago.edu FU DMID-NIAID [U01 A0177887, R01 27530] FX We gratefully thank Kevin Muite and Ani Solanki for technical help, Ernest Mui for helpful suggestions, Laura Knoll (Wisconsin) for the luciferase expressing parasites, and Boris Streipen (University of Georgia) for the RH-YFP parasites. We gratefully acknowledge support of this work from the Mann Cornwell, Engel and RooneyAlden, Lange!, Rosenthal and Jensen families. This work also was supported by DMID-NIAID U01 A0177887, R01 27530 (to RM), Knights Templar Eye Foundation (to KE), and The Research to Prevent Blindness Foundation (to RM). NR 33 TC 18 Z9 18 U1 1 U2 16 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD MAY 30 PY 2014 VL 32 IS 26 BP 3243 EP 3248 DI 10.1016/j.vaccine.2014.03.092 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA AI4YL UT WOS:000336872500020 PM 24736000 ER PT J AU Hu, FS La Scala, JJ Sadler, JM Palmese, GR AF Hu, Fengshuo La Scala, John J. Sadler, Joshua M. Palmese, Giuseppe R. TI Synthesis and Characterization of Thermosetting Furan-Based Epoxy Systems SO MACROMOLECULES LA English DT Article ID DIELS-ALDER REACTION; RENEWABLE RESOURCES; POLYMER CHEMISTRY; DIGLYCIDYL ETHER; BISPHENOL-A; BLENDS; RESINS; TEMPERATURE; BIOMASS; RELAXATIONS AB Renewable alternatives to petroleum-based thermosetting polymers have drawn significant attention due to potential positive economic and ecological impact. New materials should mimic the rigid, phenylic structure of incumbent high-performance thermoset monomers. Furans derived from cellulose and hemicellulose are promising candidates for phenyl replacement. The synthesis of furan-based diepoxies is challenging, and direct property comparisons of thermosets prepared using furanyl and phenyl-based epoxy monomer analogues are required. In this work, analogous furanyl-based and phenyl-based diepoxy monomers were synthesized, and thermosets were prepared using amine curing agents. A structure property study showed that furan-based polymers possess improved T-g (Delta = 8-16 degrees C) and improved glassy modulus (Delta = 0.1 to 0.6 GPa) relative to their phenylic analogues. The furan ring has thus been demonstrated to be a viable building block for renewable high-performance epoxies, with potential for application in other thermosetting polymers. C1 [Hu, Fengshuo; Palmese, Giuseppe R.] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. [La Scala, John J.; Sadler, Joshua M.] Army Res Labs, Aberdeen Proving Ground, MD 21005 USA. RP Palmese, GR (reprint author), Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. EM grp27@drexel.edu FU SERDP [WP-1758]; U.S. Army Research Laboratory under the Army Materials Center of Excellence Program [W911NF-06-2-0013]; China Scholarship Council FX We acknowledge financial support from SERDP under Project WP-1758 as well as from the U.S. Army Research Laboratory under the Army Materials Center of Excellence Program, contract W911NF-06-2-0013. Support from the China Scholarship Council is also acknowledged. We thank the Department of Chemistry at Drexel University for use of 1H NMR, 13C NMR, and MS facilities. NR 64 TC 33 Z9 33 U1 10 U2 88 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0024-9297 EI 1520-5835 J9 MACROMOLECULES JI Macromolecules PD MAY 27 PY 2014 VL 47 IS 10 BP 3332 EP 3342 DI 10.1021/ma500687t PG 11 WC Polymer Science SC Polymer Science GA AI1VM UT WOS:000336643300012 ER PT J AU Singh, VP Cui, HJ Byrd, AR AF Singh, Vijay P. Cui, Huijuan Byrd, Aaron R. TI Derivation of rating curve by the Tsallis entropy SO JOURNAL OF HYDROLOGY LA English DT Article DE Entropy; Rating curve; Principle of maximum entropy; Stage-discharge relation; Tsallis entropy ID STAGE-DISCHARGE RELATIONSHIP; NEURAL-NETWORKS; RIVER; MODEL; HYDRAULICS; STREAMS AB The stage-discharge relation, often called rating curve, is employed to determine discharge in natural and engineered channels. There are several methods for deriving a rating curve most of which are empirical. It is well recognized that rating curves are subjected to significant uncertainty, yet most of these methods do not have any provision to account for or do not quantify the uncertainty. This study employs the Tsallis entropy for deriving the rating curve, based on two simple constraints: (1) total probability and (2) mean discharge. Parameters of the derived curve are determined with the use of these two constraints. The rating curve is also determined by reparameterization with the use of an entropy parameter. The Tsallis entropy permits a probabilistic characterization of the rating curve and hence the probability density function of discharge underlying the curve. It also permits a quantitative assessment of the uncertainty of discharge obtained from the rating curve. The derived rating curve is found to be in agreement with field data and is also applied to ungaged watersheds. The rating curve is also extended beyond the range of discharge values used in its construction and its validity is then evaluated. Published by Elsevier B.V. C1 [Singh, Vijay P.] Texas A&M Univ, Dept Biol & Agr Engn, College Stn, TX 77843 USA. [Singh, Vijay P.] Texas A&M Univ, Zachry Dept Civil Engn, College Stn, TX 77843 USA. [Cui, Huijuan] Texas A&M Univ, Water Management & Hydrol Sci Program, College Stn, TX 77843 USA. [Byrd, Aaron R.] US Army Corps Engineers, Engineer Res Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39181 USA. RP Cui, HJ (reprint author), Texas A&M Univ, Water Management & Hydrol Sci Program, College Stn, TX 77843 USA. EM cui.huijuan@gmail.com NR 41 TC 4 Z9 4 U1 0 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1694 EI 1879-2707 J9 J HYDROL JI J. Hydrol. PD MAY 26 PY 2014 VL 513 BP 342 EP 352 DI 10.1016/j.jhydrol.2014.03.061 PG 11 WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA AI9NI UT WOS:000337258900032 ER PT J AU Idrees, M Thangavelu, K Sikaroodi, M Smith, C Sivaraman, J Gillevet, PM Bokhari, H AF Idrees, M. Thangavelu, K. Sikaroodi, M. Smith, C. Sivaraman, J. Gillevet, P. M. Bokhari, H. TI Novel fluorescent protein from Hydnophora rigida possesses green emission SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS LA English DT Article DE Hydnophora rigida; Novel green fluorescent protein; Cloning; Expression; Modeling ID MONOMERIC RED; EVOLUTION; MUTANTS; DIVERSITY; MARKER; ORANGE; CORAL; GFP AB Fluorescent proteins are a family of proteins capable of producing fluorescence at various specific wavelengths of ultra violet light. We have previously reported the identification and characterization of a novel cyan fluorescent protein (HriCFP) from a reef coral species, Hydnophora rigida. In search of new members of the, diverse family of fluorescent proteins, here we report a new green fluorescent protein (HriGFP) from H. rigida. HriGFP was identified, cloned, expressed in Escherichia coli and purified to homogeneity by metal affinity and size exclusion chromatography. The dynamic light scattering and gel filtration experiments suggested the presence of monomers in solution. The peptide mass fingerprint on the purified protein established the identity of HriGFP. HriGFP had excitation peak at 507 nm and emission peak at 527 nm. HriGFP was similar to HriCFP except the last 16 amino acid sequence at the C-terminal; however, they have shown least similarity with other known fluorescent proteins. Moreover the computational model suggests that HriGFP is a globular protein which consists of 6 alpha-helices and 3 beta-sheets. Taken together our results suggested that HriGFP is a novel naturally occurring fluorescent protein that exists as a monomer in solution. (C) 2014 Elsevier Inc. All right reserved. C1 [Idrees, M.; Bokhari, H.] COMSATS Inst Informat Technol, Dept Biosci, Islamabad, Pakistan. [Smith, C.] US Army, Engn Res & Dev Ctr, Topog Engn Ctr, Alexandria, VA USA. [Sikaroodi, M.; Smith, C.; Gillevet, P. M.] George Mason Univ, Microbiome Anal Ctr, Dept Environm Sci & Policy, Manassas, VA USA. [Sivaraman, J.] Natl Univ Singapore, Dept Biol Sci, Singapore 117548, Singapore. RP Bokhari, H (reprint author), COMSATS Inst Informat Technol, Dept Biosci, Pk Rd, Islamabad, Pakistan. EM habib@comsats.edu.pk RI idrees, muhammad/F-4415-2015; Bokhari, Syed Habib/J-2825-2015 FU Higher Education Commission of Pakistan through National Research Support Program for Universities [HEC:760]; Academic Research Fund (ARF), National University of Singapore (NUS), Singapore [WBS: R154-000-563-112] FX The author H.B. thanks the COMSATS Institute of Information Technology, Islamabad: for encouragement and Higher Education Commission of Pakistan for support through National Research Support Program for Universities (Grant No. HEC:760). The author J.S. acknowledges the research support from Academic Research Fund (ARF), National University of Singapore (NUS), Singapore (Grant No. WBS: R154-000-563-112). NR 29 TC 1 Z9 1 U1 0 U2 12 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0006-291X EI 1090-2104 J9 BIOCHEM BIOPH RES CO JI Biochem. Biophys. Res. Commun. PD MAY 23 PY 2014 VL 448 IS 1 BP 33 EP 38 DI 10.1016/j.bbrc.2014.04.042 PG 6 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA AI0RY UT WOS:000336558800006 PM 24747076 ER PT J AU Xu, K Meshik, X Nichols, BM Zakar, E Dutta, M Stroscio, MA AF Xu, Ke Meshik, Xenia Nichols, Barbara M. Zakar, Eugene Dutta, Mitra Stroscio, Michael A. TI Graphene- and aptamer-based electrochemical biosensor SO NANOTECHNOLOGY LA English DT Article DE DNA; field effect transistor; graphene; ion detection; thrombin binding aptamer (TBA) ID LABEL-FREE DETECTION; REAGENTLESS; TRANSISTORS; THROMBIN; LEAD(II); SENSOR; IONS AB This study investigated the effectiveness of a graphene- and aptamer-based field-effect-transistor-like (FET-like) sensor in detecting lead and potassium ions. The sensor consists of a graphene-covered Si/SiO2 wafer with thrombin binding aptamer (TBA) attached to the graphene layer and terminated by a methylene blue (MB) molecule. K+ and Pb2+ both bind to TBA and cause a conformational change, which results in MB moving closer to the graphene surface and donating an electron. Thus, the abundance of K+ and Pb2+ can be determined by monitoring the current across the source and drain channel. Device transfer curves were obtained with ambipolar field effect observed. Current readings were taken for K+ concentrations of 100 mu M to 50 mM and Pb2+ concentrations of 10 mu M to 10 mM. As expected, I-d decreased as ion concentration increased. In addition, there was a negative shift in V-Dirac in response to increased ion concentration. C1 [Xu, Ke; Dutta, Mitra; Stroscio, Michael A.] Univ Illinois, Dept Elect & Comp Engn, Chicago, IL 60607 USA. [Meshik, Xenia; Stroscio, Michael A.] Univ Illinois, Dept Bioengn, Chicago, IL 60607 USA. [Nichols, Barbara M.; Zakar, Eugene] US Army Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. RP Xu, K (reprint author), Univ Illinois, Dept Elect & Comp Engn, Chicago, IL 60607 USA. EM stroscio@uic.edu FU Army Research Office (ARO) through MURI [W911NF-11-1-0024] FX This work was supported by Army Research Office (ARO) through MURI grant W911NF-11-1-0024. NR 27 TC 10 Z9 11 U1 3 U2 105 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0957-4484 EI 1361-6528 J9 NANOTECHNOLOGY JI Nanotechnology PD MAY 23 PY 2014 VL 25 IS 20 AR 205501 DI 10.1088/0957-4484/25/20/205501 PG 8 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Science & Technology - Other Topics; Materials Science; Physics GA AG6FW UT WOS:000335515500007 PM 24785149 ER PT J AU Videnovic, M Opsenica, DM Burnett, JC Gomba, L Nuss, JE Selakovic, Z Konstantinovic, J Krstic, M Segan, S Zlatovic, M Sciotti, RJ Bavari, S Solaja, BA AF Videnovic, Milica Opsenica, Dejan M. Burnett, James C. Gomba, Laura Nuss, Jonathan E. Selakovic, Zivota Konstantinovic, Jelena Krstic, Maja Segan, Sandra Zlatovic, Mario Sciotti, Richard J. Bavari, Sina Solaja, Bogdan A. TI Second Generation Steroidal 4-Aminoquinolines Are Potent, Dual-Target Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease and P. falciparum Malaria SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID BETA-HEMATIN INHIBITION; ANTIMALARIAL ACTIVITY; LIGHT-CHAIN; IN-VITRO; NEUROTRANSMITTER RELEASE; CHLOROQUINE-RESISTANT; PROTEOLYTIC ACTIVITY; CYTOTOXIC ACTIVITY; DRUG DISCOVERY; SUBSTRATE AB Significantly more potent second generation 4-amino-7-chloroquinoline (4,7-ACQ) based inhibitors of the botulinum neurotoxin serotype A (BoNT/A) light chain were synthesized. Introducing an amino group at the C(3) position of the cholate component markedly increased potency (IC50 values for such derivatives ranged from 0.81 to 2.27 mu M). Two additional subclasses were prepared: bis(steroidal)-4,7-ACQ derivatives and bis(4,7-ACQ)cholate derivatives; both classes provided inhibitors with nanomolar-range potencies (e.g., the K-i of compound 67 is 0.10 mu M). During BoNT/A challenge using primary neurons, select derivatives protected SNAP-25 by up to 89%. Docking simulations were performed to rationalize the compounds' in vitro potencies. In addition to specific residue contacts, coordination of the enzyme's catalytic zinc and expulsion of the enzyme's catalytic water were a consistent theme. With respect to antimalarial activity, the compounds provided better IC90 activities against chloroquine resistant (CQR) malaria than CQ, and seven compounds were more active than mefloquine against CQR strain W2. C1 [Videnovic, Milica; Selakovic, Zivota; Krstic, Maja; Zlatovic, Mario; Solaja, Bogdan A.] Univ Belgrade, Fac Chem, Belgrade 11158, Serbia. [Opsenica, Dejan M.; Segan, Sandra] Univ Belgrade, Inst Chem Technol & Met, Belgrade 11000, Serbia. [Burnett, James C.] Leidos Biomed Res Inc, FNLCR Frederick, Computat Drug Dev Grp, Frederick, MD 21701 USA. [Gomba, Laura; Nuss, Jonathan E.] US Army Med Res Inst Infect Dis, Dept Bacteriol, Frederick, MD 21702 USA. [Konstantinovic, Jelena] Fac Chem Innovat Ctr, Belgrade 11158, Serbia. [Sciotti, Richard J.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Bavari, Sina] US Army Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Opsenica, DM (reprint author), Univ Belgrade, Inst Chem Technol & Met, Njegoseva 12, Belgrade 11000, Serbia. EM dopsen@chem.bg.ac.rs; jnuss@genevausa.org; sina.bavari.civ@mail.mil; bsolaja@chem.bg.ac.rs RI Zlatovic, Mario/E-5874-2015; Konstantinovic, Jelena/Q-5813-2016; OI Zlatovic, Mario/0000-0003-4311-1731; Konstantinovic, Jelena/0000-0002-2572-8538; Solaja, Bogdan/0000-0002-9975-2725; Videnovic, Milica/0000-0001-5606-2401 FU National Institute of Allergy and Infectious Diseases (U.S.) [5-U01AI082051-02]; Ministry of Science and Technological Development of Serbia [172008]; National Cancer Institute, National Institutes of Health (U.S.) [HHSN261200800001E] FX The authors thank Dr. Nicoletta Basilico (Dipartimento di Sanita Pubblica-Microbiologia-Virologia, Universita degli Studi di Milano, Italy) for beta-hematin formation inhibition experiments. This research was supported by National Institute of Allergy and Infectious Diseases (U.S.) Grant 5-U01AI082051-02 and by the Ministry of Science and Technological Development of Serbia (Grant 172008). Furthermore, for J.C.B., the following statement is in compliance with Leidos Biomedical Research, Inc. contractual requirements: This project has been funded in whole or in part with federal funds from the National Cancer Institute, National Institutes of Health (U.S.), under Contract HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services (U.S.) or the U.S. Army, nor does the mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government or the U.S. Army. NR 86 TC 11 Z9 11 U1 0 U2 8 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 EI 1520-4804 J9 J MED CHEM JI J. Med. Chem. PD MAY 22 PY 2014 VL 57 IS 10 BP 4134 EP 4153 DI 10.1021/jm500033r PG 20 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA AI0BB UT WOS:000336510100017 PM 24742203 ER PT J AU Olson, MA Lee, MS AF Olson, Mark A. Lee, Michael S. TI Evaluation of Unrestrained Replica-Exchange Simulations Using Dynamic Walkers in Temperature Space for Protein Structure Refinement SO PLOS ONE LA English DT Article ID GUIDED LANGEVIN DYNAMICS; MOLECULAR-DYNAMICS; STRUCTURE PREDICTION; STRUCTURE SELECTION; I-TASSER; CONFORMATIONS; MODELS; FORCE; CASP9 AB A central problem of computational structural biology is the refinement of modeled protein structures taken from either comparative modeling or knowledge-based methods. Simulations are commonly used to achieve higher resolution of the structures at the all-atom level, yet methodologies that consistently yield accurate results remain elusive. In this work, we provide an assessment of an adaptive temperature-based replica exchange simulation method where the temperature clients dynamically walk in temperature space to enrich their population and exchanges near steep energetic barriers. This approach is compared to earlier work of applying the conventional method of static temperature clients to refine a dataset of conformational decoys. Our results show that, while an adaptive method has many theoretical advantages over a static distribution of client temperatures, only limited improvement was gained from this strategy in excursions of the downhill refinement regime leading to an increase in the fraction of native contacts. To illustrate the sampling differences between the two simulation methods, energy landscapes are presented along with their temperature client profiles. C1 [Olson, Mark A.] USAMRIID, Dept Cell Biol & Biochem Mol & Translat Sci, Frederick, MD USA. [Olson, Mark A.] Johns Hopkins Univ, Zanvyl Krieger Sch Arts & Sci, Adv Acad Programs, Baltimore, MD USA. [Lee, Michael S.] US Army Res Lab, Computat Sci Div, Aberdeen Proving Ground, MD USA. RP Olson, MA (reprint author), USAMRIID, Dept Cell Biol & Biochem Mol & Translat Sci, Frederick, MD USA. EM molson@compbiophys.org FU U.S. Department of Defense Threat Reduction Agency [CBCALL12-LS6-2-0036]; Army Research Lab FX Funding of this research was provided by the U.S. Department of Defense Threat Reduction Agency Grant CBCALL12-LS6-2-0036 to MAO and the Army Research Lab to MSL. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 37 TC 3 Z9 3 U1 1 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 21 PY 2014 VL 9 IS 5 AR e96638 DI 10.1371/journal.pone.0096638 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AI3AL UT WOS:000336730600014 PM 24848767 ER PT J AU Stojadinovic, A Millia, SZ Feldman, R Avital, I AF Stojadinovic, Alexander Millia, Sherri Z. Feldman, Rebecca Avital, Itzhak TI Molecular profiling of thyroid cancers SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract CT 50th Annual Meeting of the American-Society-of-Clinical-Oncology CY MAY 30-JUN 03, 2014 CL Chicago, IL SP Amer Soc Clin Oncol C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Caris Life Sci, Phoenix, AZ USA. Bon Secours Canc Inst, Richmond, VA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2014 VL 32 IS 15 SU S MA e17008 PG 1 WC Oncology SC Oncology GA CN7KL UT WOS:000358613200918 ER PT J AU Amani, M Chin, ML Mazzoni, AL Burke, RA Najmaei, S Ajayan, PM Lou, J Dubey, M AF Amani, Matin Chin, Matthew L. Mazzoni, Alexander L. Burke, Robert A. Najmaei, Sina Ajayan, Pulickel M. Lou, Jun Dubey, Madan TI Growth-substrate induced performance degradation in chemically synthesized monolayer MoS2 field effect transistors SO APPLIED PHYSICS LETTERS LA English DT Article ID HIGH-QUALITY MONOLAYER; VAPOR-PHASE GROWTH; BILAYER MOS2; 2-DIMENSIONAL MATERIALS; MOLYBDENUM-DISULFIDE; ATOMIC LAYERS; GRAPHENE; FILMS; PHOTOLUMINESCENCE; HETEROSTRUCTURES AB We report on the electronic transport properties of single-layer thick chemical vapor deposition (CVD) grown molybdenum disulfide (MoS2) field-effect transistors (FETs) on Si/SiO2 substrates. MoS2 has been extensively investigated for the past two years as a potential semiconductor analogue to graphene. To date, MoS2 samples prepared via mechanical exfoliation have demonstrated field-effect mobility values which are significantly higher than that of CVD-grown MoS2. In this study, we will show that the intrinsic electronic performance of CVD-grown MoS2 is equal or superior to that of exfoliated material and has been possibly masked by a combination of interfacial contamination on the growth substrate and residual tensile strain resulting from the high-temperature growth process. We are able to quantify this strain in the as-grown material using pre- and post-transfer metrology and microscopy of the same crystals. Moreover, temperature-dependent electrical measurements made on as-grown and transferred MoS2 devices following an identical fabrication process demonstrate the improvement in field-effect mobility. (C) 2014 AIP Publishing LLC. C1 [Amani, Matin; Chin, Matthew L.; Mazzoni, Alexander L.; Burke, Robert A.; Dubey, Madan] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20723 USA. [Najmaei, Sina; Ajayan, Pulickel M.; Lou, Jun] Rice Univ, Dept Mat Sci & Nanoengn, Houston, TX 77005 USA. RP Dubey, M (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20723 USA. EM madan.dubey.civ@mail.mil FU U.S. Army Research Lab (ARL) Director's Strategic Initiative (DSI) program on interfaces in stacked 2D atomic layered materials; Welch Foundation [C-1716]; NSF [DMR-1327093]; U.S. Army Research Office MURI [W911NF-11-1-0362]; U.S. Office of Naval Research MURI [N000014-09-1066]; Nanoelectronics Research Corporation [S201006] FX M.A., M. L. C., A. L. M., R. A. B., and M. D. acknowledge the support of the U.S. Army Research Lab (ARL) Director's Strategic Initiative (DSI) program on interfaces in stacked 2D atomic layered materials. The authors would also like to thank Dr. Pani Varanasi of the Army Research Office for his in-depth technical discussion on 2D atomic layers R&D. S.N., P. M. A., and J.L. acknowledge the support by the Welch Foundation Grant C-1716, NSF Grant DMR-1327093, the U.S. Army Research Office MURI Grant W911NF-11-1-0362, the U.S. Office of Naval Research MURI Grant N000014-09-1066, and the Nanoelectronics Research Corporation Contract S201006. NR 39 TC 17 Z9 17 U1 6 U2 109 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAY 19 PY 2014 VL 104 IS 20 AR 203506 DI 10.1063/1.4873680 PG 5 WC Physics, Applied SC Physics GA AI8EQ UT WOS:000337140800075 ER PT J AU Fernandes, GE Kim, JH Chin, M Dhar, N Xu, J AF Fernandes, Gustavo E. Kim, Jin Ho Chin, Matthew Dhar, Nibir Xu, Jimmy TI Carbon nanotube microbolometers on suspended silicon nitride via vertical fabrication procedure SO APPLIED PHYSICS LETTERS LA English DT Article ID COMPOSITE AB We report on carbon nanotube membrane microbolometers, operating uncooled in the near-infrared (IR) and mid-IR band, with speed of 10ms and responsivity of several kV/W. The microbolometers were fabricated using a vertical process on a thin suspended silicon nitride film for thermal isolation. The measured detectivity was similar to 5.5 x 10(6) cm Hz(1/2) W-1 at 40 Hz. The broadband spectral responses measured at room temperature over the entire band of the IR illumination source are characteristic of bolometric response. These results are indicative of the potential of this platform for uncooled IR sensing and thermal imaging. The measured device noise indicated a relatively strong 1/f contribution, which is common of carbon nanotube devices operated in atmospheric conditions. The observed responses suggest, however, that oxygen adsorption/desorption reported by some researchers did not play a significant role in these devices. (C) 2014 AIP Publishing LLC. C1 [Fernandes, Gustavo E.; Kim, Jin Ho; Xu, Jimmy] Brown Univ, Sch Engn, Providence, RI 02912 USA. [Chin, Matthew; Dhar, Nibir] Army Res Lab, Adelphi, MD 20783 USA. RP Fernandes, GE (reprint author), Brown Univ, Sch Engn, 182 Hope St,Box D, Providence, RI 02912 USA. EM gustavo_fernandes@brown.edu FU U.S. Army Research Laboratory (ARL) [W911NF-12-2-0069] FX We gratefully acknowledge the support of U.S. Army Research Laboratory (ARL) Contract No. W911NF-12-2-0069. We thank Dr. Madan Dubey (ARL) for guiding discussions and for his enabling support. NR 14 TC 1 Z9 1 U1 2 U2 10 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAY 19 PY 2014 VL 104 IS 20 AR 201115 DI 10.1063/1.4879542 PG 4 WC Physics, Applied SC Physics GA AI8EQ UT WOS:000337140800015 ER PT J AU Walsh, MR Walsh, ME Gagnon, K Hewitt, AD Jenkins, TF AF Walsh, M. R. Walsh, M. E. Gagnon, K. Hewitt, A. D. Jenkins, T. F. TI Subsampling of Soils Containing Energetics Residues SO SOIL & SEDIMENT CONTAMINATION LA English DT Article DE Subsampling error; soils; particulate contaminants; energetics; replicates; grinding; subsampling increments; EPA Method 8330B ID LIVE-FIRE; VARIANCE AB There are many sources of error on the path from field sample acquisition to subsample analysis. This paper examines one potential source, the subsampling of a processed field sample. Five archived ground field samples were subsampled to determine the optimal number of increments to construct a 10-g subsample. Bulk samples ranged from 338g to 2150g. The analytes were energetic compounds: crystalline, easy-to-grind explosives and difficult-to-grind propellants in a nitrocellulose matrix. A two-phase study was conducted with moderately high concentration samples and low concentration samples of each type of analyte. All samples were ground with a puck mill according to EPA method 8330B and analyzed on liquid chromatography instrumentation. Up to 40 increments were used to build each subsample and seven replicates executed for each test. Results demonstrate that for a well-ground and mixed sample, a single 10g subsample is sufficient. For triplicate subsamples, however, 20 to 40 increments will give a result much closer to the concentration of the bulk sample. To minimize overall error due to incomplete mixing, improper grinding, or very low concentrations, we recommend about 30 increments be taken over the complete sample to construct the subsample. C1 [Walsh, M. R.; Walsh, M. E.; Gagnon, K.; Hewitt, A. D.; Jenkins, T. F.] USA CRREL, Hanover, NH 03775 USA. RP Walsh, MR (reprint author), USA CRREL, 72 Lyme Rd, Hanover, NH 03775 USA. EM Michael.Walsh@usace.army.mil NR 11 TC 2 Z9 2 U1 1 U2 13 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1532-0383 EI 1549-7887 J9 SOIL SEDIMENT CONTAM JI Soil. Sediment. Contam. PD MAY 19 PY 2014 VL 23 IS 4 BP 452 EP 463 DI 10.1080/15320383.2014.838208 PG 12 WC Environmental Sciences SC Environmental Sciences & Ecology GA 273KG UT WOS:000328533100006 ER PT J AU Geiculescu, OE Hallac, BB Rajagopal, RV Creager, SE DesMarteau, DD Borodin, O Smith, GD AF Geiculescu, Olt E. Hallac, Boutros B. Rajagopal, Rama V. Creager, Stephen E. DesMarteau, Darryl D. Borodin, Oleg Smith, Grant D. TI The Effect of Low-Molecular-Weight Poly(ethylene glycol) (PEG) Plasticizers on the Transport Properties of Lithium Fluorosulfonimide Ionic Melt Electrolytes SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID POLARIZABLE FORCE-FIELDS; DYNAMICS SIMULATIONS; POLYMER ELECTROLYTES; LI+ TRANSPORT; SALT HYBRID; CONDUCTIVITY; LITFSI; LIQUIDS; CARBONATE; OLIGOETHER AB The influence of low-molecular-weight poly(ethylene glycol) (PEG, M-w approximate to 550 Da) plasticizers on the rheology and ion-transport properties of fluorosulfonimide-based polyether ionic melt (IM) electrolytes has been investigated experimentally and via molecular dynamics (MD) simulations. Addition of PEG plasticizer to samples of IM electrolytes caused a decrease in electrolyte viscosity coupled to an increase in ionic conductivity. MD simulations revealed that addition of plasticizer increased self-diffusion coefficients for both cations and anions with the plasticizer being the fastest diffusing species. Application of a VTF model to fit variable-temperature conductivity and fluidity data shows that plasticization decreases the apparent activation energy (E-a) and pre-exponential factor A for ion transport and also for viscous flow. Increased ionic conductivity with plasticization is thought to reflect a combination of factors including lower viscosity and faster polyether chain segmental dynamics in the electrolyte, coupled with a change in the ion transport mechanism to favor ion solvation and transport by polyethers derived from the plasticizer. Current interrupt experiments with Li/electrolyte/ Li cells revealed evidence for salt concentration polarization in electrolytes containing large amounts of plasticizer but not in electrolytes without added plasticizer. C1 [Geiculescu, Olt E.; Hallac, Boutros B.; Rajagopal, Rama V.; Creager, Stephen E.; DesMarteau, Darryl D.] Clemson Univ, Dept Chem, Clemson, SC 29634 USA. [Borodin, Oleg] US Army, Res Lab, Electrochem Branch, Adelphi, MD 20783 USA. [Borodin, Oleg; Smith, Grant D.] Univ Utah, Dept Mat Sci & Engn, Salt Lake City, UT 84112 USA. [Smith, Grant D.] Wasatch Mol Inc, Salt Lake City, UT 84103 USA. RP Creager, SE (reprint author), Clemson Univ, Dept Chem, Clemson, SC 29634 USA. RI Borodin, Oleg/B-6855-2012 OI Borodin, Oleg/0000-0002-9428-5291 FU Office of FreedomCAR and Vehicle Technologies of the U.S. Department of Energy [DE-AC02-05CH11231, 6515401, 6515399]; U.S. Department of Energy [DE-IA01-11EE003413]; U.S. Army Research Laboratory FX The authors are grateful for the financial support of this work by the Assistant Secretary for Energy Efficiency and Renewable Energy, Office of FreedomCAR and Vehicle Technologies of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231 on PO No. 6515401 (University of Utah) and PO No. 6515399 (Clemson University), and an Interagency Agreement DE-IA01-11EE003413 between the U.S. Department of Energy and the U.S. Army Research Laboratory. NR 53 TC 3 Z9 3 U1 0 U2 37 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1520-6106 J9 J PHYS CHEM B JI J. Phys. Chem. B PD MAY 15 PY 2014 VL 118 IS 19 BP 5135 EP 5143 DI 10.1021/jp500826c PG 9 WC Chemistry, Physical SC Chemistry GA AH5VL UT WOS:000336199100017 PM 24773589 ER PT J AU Cravotta, CA Goode, DJ Bartles, MD Risser, DW Galeone, DG AF Cravotta, Charles A., III Goode, Daniel J. Bartles, Michael D. Risser, Dennis W. Galeone, Daniel G. TI Surface water and groundwater interactions in an extensively mined watershed, upper Schuylkill River, Pennsylvania, USA SO HYDROLOGICAL PROCESSES LA English DT Article DE abandoned mines; acid mine drainage; mine hydrology; geochemical model; groundwater model; hydrograph analysis ID COAL-MINE; TRANSPORT; DRAINAGE; EVOLUTION; SULFATE; ACIDITY; METALS; IRON; FATE AB Streams crossing underground coal mines may lose flow, whereas abandoned mine drainage (AMD) restores flow downstream. During 2005-2012, discharge from the Pine Knot Mine Tunnel, the largest AMD source in the upper Schuylkill River Basin, had near-neutral pH and elevated concentrations of iron, manganese and sulphate. Discharge from the tunnel responded rapidly to recharge but exhibited a prolonged recession compared with nearby streams, consistent with rapid infiltration of surface water and slow release of groundwater from the mine complex. Dissolved iron was attenuated downstream by oxidation and precipitation, whereas dissolved CO2 degassed and pH increased. During high flow conditions, the AMD and downstream waters exhibited decreased pH, iron and sulphate with increased acidity that were modelled by mixing net-alkaline AMD with recharge or run-off having low ionic strength and low pH. Attenuation of dissolved iron within the river was least effective during high flow conditions because of decreased transport time coupled with inhibitory effects of low pH on oxidation kinetics. A numerical model of groundwater flow was calibrated by using groundwater levels in the Pine Knot Mine and discharge data for the Pine Knot Mine Tunnel and West Branch Schuylkill River during a snowmelt event in January 2012. Although the calibrated model indicated substantial recharge to the mine complex took place away from streams, simulation of rapid changes in mine pool level and tunnel discharge during a high flow event in May 2012 required a source of direct recharge to the Pine Knot Mine. Such recharge produced small changes in mine pool level and rapid changes in tunnel flow rate because of extensive unsaturated storage capacity and high transmissivity within the mine complex. Thus, elimination of stream leakage could have a small effect on the annual discharge from the tunnel, but a large effect on peak discharge and associated water quality downstream. Published 2013. This article is a U.S. Government work and is in the public domain in the USA. C1 [Cravotta, Charles A., III; Goode, Daniel J.; Risser, Dennis W.; Galeone, Daniel G.] US Geol Survey, Penn Water Sci Ctr, University Pk, PA 16802 USA. [Bartles, Michael D.] US Army Corps Engineers, Philadelphia, PA USA. RP Cravotta, CA (reprint author), US Geol Survey, Penn Water Sci Ctr, University Pk, PA 16802 USA. EM cravotta@usgs.gov OI Goode, Daniel/0000-0002-8527-2456 NR 70 TC 9 Z9 9 U1 7 U2 54 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0885-6087 EI 1099-1085 J9 HYDROL PROCESS JI Hydrol. Process. PD MAY 15 PY 2014 VL 28 IS 10 BP 3574 EP 3601 DI 10.1002/hyp.9885 PG 28 WC Water Resources SC Water Resources GA AG8JD UT WOS:000335663700005 ER PT J AU Brown, CS Lee, MS Leung, DW Wang, TJ Xu, W Luthra, P Anantpadma, M Shabman, RS Melito, LM MacMillan, KS Borek, DM Otwinowski, Z Ramanan, P Stubbs, AJ Peterson, DS Binning, JM Tonelli, M Olson, MA Davey, RA Ready, JM Basler, CF Amarasinghe, GK AF Brown, Craig S. Lee, Michael S. Leung, Daisy W. Wang, Tianjiao Xu, Wei Luthra, Priya Anantpadma, Manu Shabman, Reed S. Melito, Lisa M. MacMillan, Karen S. Borek, Dominika M. Otwinowski, Zbyszek Ramanan, Parameshwaran Stubbs, Alisha J. Peterson, Dayna S. Binning, Jennifer M. Tonelli, Marco Olson, Mark A. Davey, Robert A. Ready, Joseph M. Basler, Christopher F. Amarasinghe, Gaya K. TI In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity SO JOURNAL OF MOLECULAR BIOLOGY LA English DT Article ID DOUBLE-STRANDED-RNA; EBOLA-VIRUS; INTERFERON ANTAGONISM; ZAIRE EBOLAVIRUS; DENDRITIC CELLS; DOMAIN; TRANSCRIPTION; PATHOGENESIS; REPLICATION; KARYOPHERIN AB The Ebola virus (EBOV) genome only encodes a single viral polypeptide with enzymatic activity, the viral large (L) RNA-dependent RNA polymerase protein. However, currently, there is limited information about the L protein, which has hampered the development of antivirals. Therefore, antifiloviral therapeutic efforts must include additional targets such as protein-protein interfaces. Viral protein 35 (VP35) is multifunctional and plays important roles in viral pathogenesis, including viral mRNA synthesis and replication of the negative-sense RNA viral genome. Previous studies revealed that mutation of key basic residues within the VP35 interferon inhibitory domain (IID) results in significant EBOV attenuation, both in vitro and in vivo. In the current study, we use an experimental pipeline that includes structure-based in silico screening and biochemical and structural characterization, along with medicinal chemistry, to identify and characterize small molecules that target a binding pocket within VP35. NMR mapping experiments and high-resolution x-ray crystal structures show that select small molecules bind to a region of VP35 IID that is important for replication complex formation through interactions with the viral nucleoprotein (NP). We also tested select compounds for their ability to inhibit VP35 IID-NP interactions in vitro as well as VP35 function in a minigenome assay and EBOV replication. These results confirm the ability of compounds identified in this study to inhibit VP35-NP interactions in vitro and to impair viral replication in cell-based assays. These studies provide an initial framework to guide development of antifiloviral compounds against filoviral VP35 proteins. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Brown, Craig S.; Leung, Daisy W.; Xu, Wei; Ramanan, Parameshwaran; Binning, Jennifer M.; Amarasinghe, Gaya K.] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA. [Brown, Craig S.; Wang, Tianjiao; Stubbs, Alisha J.; Peterson, Dayna S.] Iowa State Univ, Roy J Carver Dept Biochem Biophys & Mol Biol, Ames, IA 50011 USA. [Brown, Craig S.; Stubbs, Alisha J.; Peterson, Dayna S.] Iowa State Univ, Biochem Undergrad Program, Ames, IA 50011 USA. [Lee, Michael S.] US Army Res Lab, Simulat Sci Branch, Aberdeen, MD 21005 USA. [Lee, Michael S.; Olson, Mark A.] USAMRIID, Dept Cell Biol & Biochem, Ft Detrick, MD 21702 USA. [Luthra, Priya; Shabman, Reed S.; Basler, Christopher F.] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA. [Anantpadma, Manu; Davey, Robert A.] Texas Biomed Res Inst, Dept Virol & Immunol, San Antonio, TX 78227 USA. [Melito, Lisa M.; MacMillan, Karen S.; Borek, Dominika M.; Otwinowski, Zbyszek; Ready, Joseph M.] Univ Texas SW Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA. [Borek, Dominika M.; Otwinowski, Zbyszek] Univ Texas SW Med Ctr Dallas, Dept Biophys, Dallas, TX 75390 USA. [Borek, Dominika M.; Otwinowski, Zbyszek] Ctr Struct Genom Infect Dis, Chicago, IL USA. [Ramanan, Parameshwaran; Binning, Jennifer M.] Iowa State Univ, Biochem Grad Program, Ames, IA 50011 USA. [Tonelli, Marco] Univ Wisconsin, Natl Magnet Resonance Facil Madison, Madison, WI 53706 USA. RP Amarasinghe, GK (reprint author), Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA. EM gamarasinghe@path.wustl.edu RI Borek, Dominika/D-2943-2011; OI Borek, Dominika/0000-0002-4321-6253; Anantpadma, Manu/0000-0001-5796-532X; Shabman, Reed/0000-0003-3272-3484 FU U.S. Department of Energy [DE-AC02-06CH11357]; Center for Structural Genomics of Infectious Diseases under the NIAID/NIH/DHS [HHSN272200700058C, HHSN272201200026C]; National Institutes of Health [R01AI081914, R01AI059536, R56AI089547, R56AI093786, R21AI097568, P41RR02301, P41GM66326, RR02781, RR08438]; Midwest Regional Center of Excellence Developmental Grant [U54AI057160-Virgin]; Welch Foundation [I-1612]; DoD Defense Threat Reduction Agency [4.10011_07_RD_B]; National Magnetic Resonance Facility at Madison; University of Wisconsin; National Science Foundation [DMB-8415048, OIA-9977486, BIR-9214394]; U.S. Department of Agriculture FX We thank Drs. S. Ginell, N. Duke, F. Rotella, K. Lazarski, and J. Lazarz at Argonne National Laboratory Structural Biology Center Beam lines (SBC). SBC is supported by the U.S. Department of Energy under contract DE-AC02-06CH11357. D.M.B. and Z.O. are supported in part by the Center for Structural Genomics of Infectious Diseases under the NIAID/NIH/DHS Contracts HHSN272200700058C and HHSN272201200026C Anderson (PI). This work is supported in part by National Institutes of Health grants (R01AI081914 to G.K.A. and R01AI059536, R56AI089547, R56AI093786, and R21AI097568 to C.F.B.), a Midwest Regional Center of Excellence Developmental Grant [U54AI057160-Virgin (PI) to G.K.A.], and the Welch Foundation (I-1612 to J.M.R.). DoD Defense Threat Reduction Agency Grant 4.10011_07_RD_B to M. A. O. This study made use of the National Magnetic Resonance Facility at Madison, which is supported by National Institutes of Health grants P41RR02301 (Biomedical Research Technology Program, National Center for Research Resources) and P41GM66326 (National Institute of General Medical Sciences). Equipment in the facility was purchased with funds from the University of Wisconsin, the National Institutes of Health (P41GM66326, P41RR02301, RR02781, and RR08438), the National Science Foundation (DMB-8415048, OIA-9977486, and BIR-9214394), and the U.S. Department of Agriculture. NR 43 TC 17 Z9 19 U1 1 U2 47 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0022-2836 EI 1089-8638 J9 J MOL BIOL JI J. Mol. Biol. PD MAY 15 PY 2014 VL 426 IS 10 BP 2045 EP 2058 DI 10.1016/j.jmb.2014.01.010 PG 14 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA AH7XP UT WOS:000336349000003 PM 24495995 ER PT J AU Reisner, A Chen, XX Kumar, K Reifman, J AF Reisner, Andrew Chen, Xiaoxiao Kumar, Kamal Reifman, Jaques TI Prehospital Heart Rate and Blood Pressure Increase the Positive Predictive Value of the Glasgow Coma Scale for High-Mortality Traumatic Brain Injury SO JOURNAL OF NEUROTRAUMA LA English DT Article DE heart rate; prehospital; Glasgow Coma Scale; traumatic brain injury; blood pressure ID SCORING SYSTEM; FIELD TRIAGE; ALGORITHMS; INTUBATION; VICTIMS; SCORES; IMPACT; AGE AB We hypothesized that vital signs could be used to improve the association between a trauma patient's prehospital Glasgow Coma Scale (GCS) score and his or her clinical condition. Previously, abnormally low and high blood pressures have both been associated with higher mortality for patients with traumatic brain injury (TBI). We undertook a retrospective analysis of 1384 adult prehospital trauma patients. Vital-sign data were electronically archived and analyzed. We examined the relative risk of severe head Abbreviated Injury Scale (AIS) 5-6 as a function of the GCS, systolic blood pressure (SBP), heart rate (HR), and respiratory rate (RR). We created multi-variate logistic regression models and, using DeLong's test, compared their area under receiver operating characteristic curves (ROC AUCs) for three outcomes: head AIS 5-6, all-cause mortality, and either head AIS 5-6 or neurosurgical procedure. We found significant bimodal relationships between head AIS 5-6 versus SBP and HR, but not RR. When the GCS was <15, ROC AUCs were significantly higher for a multi-variate regression model (GCS, SBP, and HR) versus GCS alone. In particular, patients with abnormalities in all parameters (GCS, SBP, and HR) were significantly more likely to have high-mortality TBI versus those with abnormalities in GCS alone. This could be useful for mobilizing resources (e.g., neurosurgeons and operating rooms at the receiving hospital) and might enable new prehospital management protocols where therapies are selected based on TBI mortality risk. C1 [Reisner, Andrew; Chen, Xiaoxiao; Kumar, Kamal; Reifman, Jaques] US Army, Biotechnol High Performance Comp Software Applica, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. [Reisner, Andrew] Massachusetts Gen Hosp, Dept Emergency Med, Boston, MA 02114 USA. RP Reifman, J (reprint author), US Army, Biotechnol HPC Inst, Med Res & Mat Command, MCMR TT, 504 Scott St, Ft Detrick, MD 21702 USA. EM jaques.reifman.civ@mail.mil OI Kumar, Kamal/0000-0002-9470-6682 FU Defense Health Program; Combat Casualty Care Research Area Directorate of the U.S. Army Medical Research and Materiel Command (Fort Detrick, MD) FX This work was supported by the Defense Health Program and the Combat Casualty Care Research Area Directorate of the U.S. Army Medical Research and Materiel Command (Fort Detrick, MD). The authors thank Christopher Jamieson for his support in formatting the manuscript and Kathleen McGuire Gilbert for editing the manuscript. NR 33 TC 2 Z9 3 U1 0 U2 3 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD MAY 15 PY 2014 VL 31 IS 10 BP 906 EP 913 DI 10.1089/neu.2013.3128 PG 8 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AH1ES UT WOS:000335863200003 PM 24372334 ER EF