FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Bickford, JR Lopez, G Belic, N Hofmann, U AF Bickford, Justin R. Lopez, Gerald Belic, Nikola Hofmann, Ulrich TI Hydrogen silsesquioxane on SOI proximity and microloading effects correction from a single 1D characterization sample SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article ID ELECTRON-BEAM LITHOGRAPHY; RESIST; CONTRAST; TIME AB Designs patterned by electron beam lithography without applying process effect correction exhibit overexposed dense features and underexposed sparse features for most practical exposure scenarios. This is typified by the limited exposure latitude of hydrogen silsesquioxane resist on silicon-on-insulator substrates used for silicon photonics, which commonly display very high density features (vertical grating couplers, ring resonators) mixed with very sparse features (inverse tapered waveguides, lone waveguides) in a single pattern. The authors have optimized a proximity effect correction (PEC) based on our analysis of a single 1D process control monitor characterization sample. Our PEC verification sample, which includes electron backscatter and process-related microloading effects, achieved linewidths with an RMS error of +/-5.0 nm for features with pattern densities spanning 1%-67%. Ignoring the pattern density-dependent microloading effect limits the resolvable pattern density span to a smaller range and degrades the linewidth error. (C) 2014 American Vacuum Society. C1 [Bickford, Justin R.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Lopez, Gerald; Belic, Nikola; Hofmann, Ulrich] GenISys GmbH, D-82024 Taufkirchen, Germany. RP Bickford, JR (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Dr, Adelphi, MD 20783 USA. EM justin.r.bickford.civ@mail.mil NR 15 TC 1 Z9 1 U1 0 U2 2 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD NOV PY 2014 VL 32 IS 6 AR 06F511 DI 10.1116/1.4901567 PG 7 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA AU3KU UT WOS:000345512800014 ER PT J AU Liu, Z Amani, M Najmaei, S Xu, Q Zou, XL Zhou, W Yu, T Qiu, CY Birdwell, AG Crowne, FJ Vajtai, R Yakobson, BI Xia, ZH Dubey, M Ajayan, PM Lou, J AF Liu, Zheng Amani, Matin Najmaei, Sina Xu, Quan Zou, Xiaolong Zhou, Wu Yu, Ting Qiu, Caiyu Birdwell, A. Glen Crowne, Frank J. Vajtai, Robert Yakobson, Boris I. Xia, Zhenhai Dubey, Madan Ajayan, Pulickel M. Lou, Jun TI Strain and structure heterogeneity in MoS2 atomic layers grown by chemical vapour deposition SO NATURE COMMUNICATIONS LA English DT Article ID METAL DICHALCOGENIDE NANOSHEETS; MONOLAYER MOLYBDENUM-DISULFIDE; TOTAL-ENERGY CALCULATIONS; AUGMENTED-WAVE METHOD; RAMAN-SPECTROSCOPY; UNIAXIAL STRAIN; PHASE GROWTH; THIN MOS2; BASIS-SET; PHOTOLUMINESCENCE AB Monolayer molybdenum disulfide (MoS2) has attracted tremendous attention due to its promising applications in high-performance field-effect transistors, phototransistors, spintronic devices and nonlinear optics. The enhanced photoluminescence effect in monolayer MoS2 was discovered and, as a strong tool, was employed for strain and defect analysis in MoS2. Recently, large-size monolayer MoS2 has been produced by chemical vapour deposition, but has not yet been fully explored. Here we systematically characterize chemical vapour deposition-grown MoS2 by photoluminescence spectroscopy and mapping and demonstrate non-uniform strain in single-crystalline monolayer MoS2 and strain-induced bandgap engineering. We also evaluate the effective strain transferred from polymer substrates to MoS2 by three-dimensional finite element analysis. Furthermore, our work demonstrates that photoluminescence mapping can be used as a non-contact approach for quick identification of grain boundaries in MoS2. C1 [Liu, Zheng] Nanyang Technol Univ, Sch Mat Sci & Engn, Singapore 639798, Singapore. [Liu, Zheng] Nanyang Technol Univ, NOVITAS, Nanoelect Ctr Excellence, Sch Elect & Elect Engn, Singapore 639798, Singapore. [Liu, Zheng] CINTRA CNRS NTU THALES, UMI 3288, Singapore 637553, Singapore. [Amani, Matin; Birdwell, A. Glen; Crowne, Frank J.; Dubey, Madan] US Army, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. [Najmaei, Sina; Zou, Xiaolong; Vajtai, Robert; Yakobson, Boris I.; Ajayan, Pulickel M.; Lou, Jun] Rice Univ, Dept Mat Sci & Nanoengn, Houston, TX 77005 USA. [Xu, Quan; Xia, Zhenhai] Univ N Texas, Dept Mat Sci & Engn, Denton, TX 76203 USA. [Xu, Quan] China Univ Petr, Inst New Energy, Beijing 102200, Peoples R China. [Zhou, Wu] Oak Ridge Natl Lab, Mat Sci & Technol Div, Oak Ridge, TN 37831 USA. [Yu, Ting; Qiu, Caiyu] Nanyang Technol Univ, Sch Phys & Math Sci, Div Phys & Appl Phys, Singapore 637371, Singapore. RP Lou, J (reprint author), Rice Univ, Dept Mat Sci & Nanoengn, Houston, TX 77005 USA. EM madan.dubey.civ@mail.mil; ajayan@rice.edu; jlou@rice.edu RI Liu, Zheng/C-1813-2014; Zhou, Wu/D-8526-2011 OI Liu, Zheng/0000-0002-8825-7198; Zhou, Wu/0000-0002-6803-1095 FU Welch Foundation [C-1716]; NSF [ECCS-1327093, CNS-0821727, OCI-0959097]; U.S. Army Research Office MURI grant [W911NF-11-1-0362]; U.S. Army Research Lab (ARL) Director's Strategic Initiative (DSI) program on interfaces in stacked 2D atomic layered materials; U.S. Office of Naval Research MURI grant [N000014-09-1-1066]; Nanoelectronics Research Corporation [S201006]; Wigner Fellowship through the Laboratory Directed Research and Development Program of Oak Ridge National Laboratory; ORNL's Center for Nanophase Materials Sciences (CNMS); Scientific User Facilities Division, Office of Basic Energy Sciences, U.S. DOE; FAME Center; MARCO, one of six centres of STARnet; DARPA; Singapore National Research Foundation under NRF RF Award [NRF-RF2013-08]; Nanyang Technological University [M4081137.070] FX This work was supported by the Welch Foundation grant C-1716, the NSF grant ECCS-1327093, the U.S. Army Research Office MURI grant W911NF-11-1-0362, the U.S. Army Research Lab (ARL) Director's Strategic Initiative (DSI) program on interfaces in stacked 2D atomic layered materials, the U.S. Office of Naval Research MURI grant N000014-09-1-1066, the Nanoelectronics Research Corporation contract S201006, a Wigner Fellowship through the Laboratory Directed Research and Development Program of Oak Ridge National Laboratory, managed by UT-Battelle, LLC, for the U.S. DOE (W.Z.), and through a user project supported by ORNL's Center for Nanophase Materials Sciences (CNMS), which is sponsored by the Scientific User Facilities Division, Office of Basic Energy Sciences, U.S. DOE. This work was also supported in part by the FAME Center, one of six centres of STARnet, a Semiconductor Research Corporation program sponsored by MARCO and DARPA. This work was also supported by the Singapore National Research Foundation under NRF RF Award No. NRF-RF2013-08, the start-up funding from Nanyang Technological University (M4081137.070). The computations were performed at the Cyberinfrastructure for Computational Research funded by NSF under Grant CNS-0821727 and the Data Analysis and Visualization Cyberinfrastructure funded by NSF under Grant OCI-0959097. NR 41 TC 75 Z9 75 U1 19 U2 222 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2041-1723 J9 NAT COMMUN JI Nat. Commun. PD NOV PY 2014 VL 5 AR 5246 DI 10.1038/ncomms6246 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AU5NJ UT WOS:000345653500001 PM 25404060 ER PT J AU Bebarta, VS Pitotti, RL Boudreau, S Tanen, DA AF Bebarta, Vikhyat S. Pitotti, Rebecca L. Boudreau, Susan Tanen, David A. TI Intraosseous Versus Intravenous Infusion of Hydroxocobalamin for the Treatment Of Acute Severe Cyanide Toxicity in a Swine Model SO ACADEMIC EMERGENCY MEDICINE LA English DT Article ID ADVANCED LIFE-SUPPORT; SUS-SCROFA MODEL; SODIUM THIOSULFATE; HEMORRHAGIC-SHOCK; VASCULAR ACCESS; CARDIAC-ARREST; RESUSCITATION; INFLAMMATION; EPINEPHRINE; STATEMENT AB ObjectivesEasily administrated cyanide antidotes are needed for first responders, military troops, and emergency department staff after cyanide exposure in mass casualty incidents or due to smoke inhalation during fires involving many victims. Hydroxocobalamin has proven to be an effective antidote, but cannot be given intramuscularly because the volume of diluent needed is too large. Thus, intraosseous (IO) infusion may be an alternative, as it is simple and has been recommended for the administration of other resuscitation drugs. The primary objective of this study was to compare the efficacy of IO delivery of hydroxocobalamin to intravenous (IV) injection for the management of acute cyanide toxicity in a well-described porcine model. MethodsTwenty-four swine (45 to 55kg) were anesthetized, intubated, and instrumented with continuous mean arterial pressure (MAP) and cardiac output monitoring. Cyanide was continuously infused until severe hypotension (50% of baseline MAP), followed by IO or IV hydroxocobalamin treatment. Animals were randomly assigned to receive IV (150mg/kg) or IO (150mg/kg) hydroxocobalamin and monitored for 60minutes after start of antidotal infusion. The primary outcome measure was the change in MAP after antidotal treatment from onset of hypotension (time zero) to 60minutes. A sample size of 12 animals per group was determined by group size analysis based on power of 80% to detect a one standard deviation of the mean MAP between the groups with an alpha of 0.05. Whole blood cyanide, lactate, pH, nitrotyrosine (nitric oxide marker) levels, cerebral and renal near infrared spectrometry (NIRS) oxygenation, and inflammatory markers were also measured. Repeated-measures analysis of variance was used to determine statistically significant changes between groups over time. ResultsAt baseline and at the point of hypotension, physiologic parameters were similar between groups. At the conclusion of the study, 10 out of 12 animals in the IV group and 10 out of 12 in IO group survived (p=1.0). Both groups demonstrated a similar return to baseline MAP (p=0.997). Cardiac output, oxygen saturation, and systemic vascular resistance were also found to be similar between groups (p>0.4), and no difference was detected between bicarbonate, pH, and lactate levels (p>0.8). Cyanide levels were undetectable after the hydroxocobalamin infusion throughout the study in both groups (p=1.0). Cerebral and renal NIRS oxygenation decreased in parallel to MAP during cyanide infusion and increased after antidote infusion in both groups. Serum nitrotyrosine increased during cyanide infusion in all animals and then decreased in both study arms after hydroxocobalamin infusion (p>0.5). Serum cytokines increased starting at cyanide infusion and no difference was detected between groups (tumor necrosis factor-, interleukin [IL]-1, IL-6, and IL-10). ConclusionsThe authors found no difference in the efficacy of IV versus IO hydroxocobalamin in the treatment of severe cyanide toxicity in a validated porcine model. Resumen Objetivosse necesitan antidotos para el cianuro de facil administracion para los primeros respondedores, las tropas militares y el personal del servicio de urgencias tras una exposicion al mismo en grandes cantidades o debido a la inhalacion de humo durante fuegos que involucren a muchas victimas. La hidroxocobalamina ha demostrado ser un antidoto efectivo, pero no puede ser administrada por via intramuscular debido a que el volumen de disolvente necesario es demasiado grande. Por ello, la via intraosea (IO) puede ser una alternativa, por su sencillez, y ha sido recomendada para la administracion de otros farmacos durante la resucitacion. El objetivo principal del estudio fue comparar la eficacia de la administracion IO de hidroxocobalamina con la inyeccion IV para el manejo de la intoxicacion aguda por cianuro en un modelo porcino bien descrito. MetodologiaVeinticuatro cerdos (45 a 55kg) se anestesiaron, intubaron e instrumentalizaron con monitorizacion continua de la presion arterial media (PAM) y el gasto cardiaco. El cianuro se perfundio de forma continua hasta la hipotension grave (50% de la PAM basal) seguido por el tratamiento con hidroxocobalamina IO o IV. Los animales fueron asignados de forma aleatorizada a recibir hidroxocobalamina por via IV (150mg/kg) o IO (150mg/kg) y fueron monitorizados durante 60 minutos tras el inicio de la infusion del antidoto. La medida de resultado principal fue el cambio en la PAM tras el tratamiento con el antidoto desde el inicio de la hipotension (tiempo cero) hasta los 60 minutos. Se determino un tamano muestral de 12 animales por grupo basandose en un poder del 80% para detectar una desviacion estandar de la media de PAM entre los grupos con un error alfa de 0,05. Se midio tambien el cianuro en sangre, lactato, pH, niveles nitrotirosina (marcador de oxido nitrico), la oxigenacion cerebral y renal mediante un espectrometro de infrarrojo cercano (NIRS, near infrared spectrometry) y marcadores de inflamacion. Se utilizo el analisis de la varianza para medidas repetidas para determinar los cambios estadisticamente significativos entre los grupos con el paso del tiempo. ResultadosBasalmente y en el momento de la hipotension, los parametros fisiologicos fueron similares entre los grupos. Al final del estudio, 10 de los 12 animales en el grupo IV y 10 de los 12 en el grupo IO sobrevivieron (p=1.0). Ambos grupos demostraron un retorno similar a la PAM basal (p=0,997). El gasto cardiaco, la saturacion de oxigeno y la resistencia vascular sistemica se encontraron tambien similares entre los grupos (p>0,4); y no se detectaron diferencias entre los niveles de bicarbonato, pH y lactato (p>0,8). Las concentraciones de cianuro fueron indetectables tras la infusion de hidroxocobalamina durante el estudio en ambos grupos (p=1.0). La oxigenacion cerebral y renal mediante espectroscopia funcional cercana al infrarrojo disminuyo de forma paralela a la PAM durante la infusion de cianuro y se incremento tras la infusion del antidoto en ambos grupos. La nitrotirosina serica se incremento durante la infusion de cianuro en todos los animales y despues descendio en ambos brazos del estudio tras la infusion de hidroxicobalamina (p >0,5). Las citoquinas sericas se incrementaron al iniciar la infusion de cianuro y no se detecto diferencia entre los grupos (TNF-, IL-1, IL-6, y IL-10). ConclusionesNo se encontraron diferencias en la eficacia de la hidroxocobalimina intravenosa frente a la intraosea en el tratamiento de la intoxicacion grave por cianuro en un modelo porcino validado. C1 [Bebarta, Vikhyat S.] US Army, San Antonio Mil Med Ctr, Inst Surg Res, San Antonio, TX 78234 USA. [Bebarta, Vikhyat S.] US Army, Enroute Care Res Ctr, Inst Surg Res, San Antonio, TX USA. [Pitotti, Rebecca L.; Boudreau, Susan] San Antonio Mil Med Ctr, Dept Emergency Med, San Antonio, TX USA. [Tanen, David A.] Univ Calif Los Angeles, David Geffen Sch Med, Harbor UCLA Med Ctr, Los Angeles, CA 90095 USA. RP Bebarta, VS (reprint author), US Army, San Antonio Mil Med Ctr, Inst Surg Res, San Antonio, TX 78234 USA. EM vikbebarta@yahoo.com RI bebarta, vikhyat/K-3476-2015 NR 36 TC 1 Z9 1 U1 1 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1069-6563 EI 1553-2712 J9 ACAD EMERG MED JI Acad. Emerg. Med. PD NOV PY 2014 VL 21 IS 11 BP 1203 EP 1211 DI 10.1111/acem.12518 PG 9 WC Emergency Medicine SC Emergency Medicine GA AT9GZ UT WOS:000345237300003 PM 25377396 ER PT J AU Kragh, JF Darrah, M Gradilla, C Salinas, J Aden, JK Dubick, MA AF Kragh, John F., Jr. Darrah, Mark Gradilla, Cesar Salinas, Jose Aden, James K., III Dubick, Michael A. TI An intelligent tourniquet system to stop traumatic extremity bleeding SO AMERICAN JOURNAL OF EMERGENCY MEDICINE LA English DT Letter ID COMBAT CASUALTY CARE C1 [Kragh, John F., Jr.] US Army, Inst Surg Res, JBSA Ft Sam, Houston, TX 78234 USA. [Darrah, Mark; Gradilla, Cesar] Athena GTX Corp, Des Moines, IA 50321 USA. [Salinas, Jose; Aden, James K., III; Dubick, Michael A.] US Army, Inst Surg Res, Houston, TX 78234 USA. RP Kragh, JF (reprint author), US Army, Inst Surg Res, JBSA Ft Sam, 3698 Chambers Pass,Ste B, Houston, TX 78234 USA. EM john.f.kragh.civ@mail.mil NR 6 TC 0 Z9 0 U1 0 U2 2 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0735-6757 EI 1532-8171 J9 AM J EMERG MED JI Am. J. Emerg. Med. PD NOV PY 2014 VL 32 IS 11 BP 1419 EP 1421 DI 10.1016/j.ajem.2014.08.020 PG 3 WC Emergency Medicine SC Emergency Medicine GA AT4ZC UT WOS:000344951600027 PM 25190549 ER PT J AU Li, ZX Roussakis, E Koolen, PGL Ibrahim, AMS Kim, K Rose, LF Wu, J Nichols, AJ Baek, Y Birngruber, R Apiou-Sbirlea, G Matyal, R Huang, T Chan, R Lin, SJ Evans, CL AF Li, Zongxi Roussakis, Emmanuel Koolen, Pieter G. L. Ibrahim, Ahmed M. S. Kim, Kuylhee Rose, Lloyd F. Wu, Jesse Nichols, Alexander J. Baek, Yunjung Birngruber, Reginald Apiou-Sbirlea, Gabriela Matyal, Robina Huang, Thomas Chan, Rodney Lin, Samuel J. Evans, Conor L. TI Non-invasive transdermal two-dimensional mapping of cutaneous oxygenation with a rapid-drying liquid bandage SO BIOMEDICAL OPTICS EXPRESS LA English DT Article ID LIMB ISCHEMIA; SKIN; PHOSPHORESCENCE; HYPOXIA; TENSION; BURNS; INDICATORS; COMPLEXES; SYSTEMS; PROBES AB Oxygen plays an important role in wound healing, as it is essential to biological functions such as cell proliferation, immune responses and collagen synthesis. Poor oxygenation is directly associated with the development of chronic ischemic wounds, which affect more than 6 million people each year in the United States alone at an estimated cost of $25 billion. Knowledge of oxygenation status is also important in the management of burns and skin grafts, as well as in a wide range of skin conditions. Despite the importance of the clinical determination of tissue oxygenation, there is a lack of rapid, user-friendly and quantitative diagnostic tools that allow for non-disruptive, continuous monitoring of oxygen content across large areas of skin and wounds to guide care and therapeutic decisions. In this work, we describe a sensitive, colorimetric, oxygen-sensing paint-on bandage for two-dimensional mapping of tissue oxygenation in skin, burns, and skin grafts. By embedding both an oxygen-sensing porphyrin-dendrimer phosphor and a reference dye in a liquid bandage matrix, we have created a liquid bandage that can be painted onto the skin surface and dries into a thin film that adheres tightly to the skin or wound topology. When captured by a camera-based imaging device, the oxygen-dependent phosphorescence emission of the bandage can be used to quantify and map both the pO(2) and oxygen consumption of the underlying tissue. In this proof-of-principle study, we first demonstrate our system on a rat ischemic limb model to show its capabilities in sensing tissue ischemia. It is then tested on both ex vivo and in vivo porcine burn models to monitor the progression of burn injuries. Lastly, the bandage is applied to an in vivo porcine graft model for monitoring the integration of full-and partial-thickness skin grafts. (C) 2014 Optical Society of America C1 [Li, Zongxi; Roussakis, Emmanuel; Nichols, Alexander J.; Baek, Yunjung; Apiou-Sbirlea, Gabriela; Evans, Conor L.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Wellman Ctr Photomed, Charlestown, MA 02129 USA. [Koolen, Pieter G. L.; Ibrahim, Ahmed M. S.; Kim, Kuylhee; Lin, Samuel J.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Div Plast Surg, Charlestown, MA 02129 USA. [Rose, Lloyd F.; Wu, Jesse; Chan, Rodney] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Nichols, Alexander J.; Evans, Conor L.] Harvard Univ, Program Biophys, Boston, MA 02115 USA. [Nichols, Alexander J.] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA. [Baek, Yunjung] Korea Adv Inst Sci & Technol, Dept Chem, Taejon 305701, South Korea. [Birngruber, Reginald] Med Univ Lubeck, Inst Biomed Opt, D-23562 Lubeck, Germany. [Matyal, Robina; Huang, Thomas] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02215 USA. RP Li, ZX (reprint author), Harvard Univ, Massachusetts Gen Hosp, Sch Med, Wellman Ctr Photomed, 149 13th St, Charlestown, MA 02129 USA. EM evans.conor@mgh.harvard.edu RI Birngruber, Reginald/Q-2342-2016 FU Air Force Office for Scientific Research [FA9550-13-1-0068]; National Institute of Health [1 DP2 OD007096-1] FX The authors would like to thank Joachim Pruessner (Api) for his help with diagram design and creation. This research is sponsored in part by the Air Force Office for Scientific Research, under grant number: FA9550-13-1-0068. The authors also gratefully acknowledge funding from the National Institute of Health, under grant number: 1 DP2 OD007096-1. Information on the New Innovator Award Program is at http://nihroadmap.nih.gov/newinnovator/. NR 39 TC 11 Z9 12 U1 4 U2 29 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 2156-7085 J9 BIOMED OPT EXPRESS JI Biomed. Opt. Express PD NOV 1 PY 2014 VL 5 IS 11 BP 3748 EP 3764 DI 10.1364/BOE.5.003748 PG 17 WC Biochemical Research Methods; Optics; Radiology, Nuclear Medicine & Medical Imaging SC Biochemistry & Molecular Biology; Optics; Radiology, Nuclear Medicine & Medical Imaging GA AT4UR UT WOS:000344939400001 PM 25426308 ER PT J AU Black, A Pinsky, PF Grubb, RL Falk, RT Hsing, AW Chu, LS Meyer, T Veenstra, TD Xu, X Yu, K Ziegler, RG Brinton, LA Hoover, RN Cook, MB AF Black, Amanda Pinsky, Paul F. Grubb, Robert L., III Falk, Roni T. Hsing, Ann W. Chu, Lisa Meyer, Tamra Veenstra, Timothy D. Xu, Xia Yu, Kai Ziegler, Regina G. Brinton, Louise A. Hoover, Robert N. Cook, Michael B. TI Sex Steroid Hormone Metabolism in Relation to Risk of Aggressive Prostate Cancer SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION LA English DT Article ID URINARY ESTROGEN METABOLITES; BREAST-CANCER; MASS-SPECTROMETRY; SCREENING TRIAL; UNITED-STATES; SERUM; MEN; METAANALYSIS; AMERICANS; ETIOLOGY AB Background: The combined action of androgens and estrogens-specifically their balance-may play a role in prostate carcinogenesis, but existing evidence is sparse and inconsistent. We investigated associations between serum sex steroid hormones, including estrogen metabolites, and risk of aggressive prostate cancer. Methods: In a case-control study nested within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial cohort, we measured serum estrone, estradiol, and 13 estrogen metabolites, in the 2-, 4-, or 16-hydroxylation pathways, using an LC/MS-MS assay. Cases (n = 195) were non-Hispanic white men ages 55 to 70 years when diagnosed with aggressive prostate cancer (stage III or IV and/or Gleason >= 7). Controls (n = 195) were non-Hispanic white men without prostate cancer who were frequency matched to cases by age and year at blood draw, and time since baseline screen. Only men with serum testosterone and sex hormone-binding globulin measured previously were eligible. Logistic regression models were used to estimate ORs and 95% confidence intervals (95% CI). Results: Risk of aggressive prostate cancer was strongly inversely associated with estradiol: testosterone ratio (OR4th quartile vs. (1st) = 0.27; 95% CI, 0.12-0.59, P-trend = 0.003) and positively associated with 2: 16 alpha-hydroxyestrone ratio (OR4(th quartile) vs. (1st) = 2.44; 95% CI, 1.34-4.45, P-trend = 0.001). Individual estrogen metabolites were unrelated to risk. Conclusions: Our findings suggest that sex steroid hormones, specifically the estrogen-androgen balance, may be important in the development of aggressive prostate cancer. Impact: Improved understanding of the hormonal etiology of prostate cancer is critical for prevention and therapeutic interventions. (C) 2014 AACR. C1 [Black, Amanda; Falk, Roni T.; Yu, Kai; Ziegler, Regina G.; Brinton, Louise A.; Hoover, Robert N.; Cook, Michael B.] NCI, Div Canc Epidemiol & Genet, NIH, US Dept HHS, Rockville, MD 20850 USA. [Pinsky, Paul F.] NCI, Canc Prevent Div, NIH, US Dept HHS, Rockville, MD 20850 USA. [Grubb, Robert L., III] Washington Univ, St Louis, MO USA. [Hsing, Ann W.; Chu, Lisa] Canc Prevent Inst Calif, Fremont, CA USA. [Hsing, Ann W.; Chu, Lisa] Stanford Canc Inst, Palo Alto, CA USA. [Meyer, Tamra] US Army Med Command, Pharmacovigilance Ctr, Falls Church, VA USA. [Veenstra, Timothy D.] C2N Diagnost, St Louis, MO USA. [Xu, Xia] Frederick Natl Lab Canc Res, Leidos Biomed Res Inc, Canc Res Technol Program, Frederick, MD USA. RP Black, A (reprint author), NCI, Div Canc Epidemiol & Genet, NIH, US Dept HHS, 9609 Med Ctr Dr,Suite 7-E582,MSC 9773, Rockville, MD 20850 USA. EM blacka@mail.nih.gov RI Brinton, Louise/G-7486-2015; Cook, Michael/A-5641-2009 OI Brinton, Louise/0000-0003-3853-8562; Cook, Michael/0000-0002-0533-7302 FU Intramural Research Program of the National Cancer Institute, NIH; Leidos Biomedical Research, Inc. [HHSN261200800001E] FX This work was supported by the Intramural Research Program of the National Cancer Institute, NIH. This work was performed, in part, under contract HHSN261200800001E with Leidos Biomedical Research, Inc. NR 37 TC 9 Z9 10 U1 0 U2 5 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1055-9965 EI 1538-7755 J9 CANCER EPIDEM BIOMAR JI Cancer Epidemiol. Biomarkers Prev. PD NOV PY 2014 VL 23 IS 11 BP 2374 EP 2382 DI 10.1158/1055-9965.EPI-14-0700 PG 9 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA AT9YL UT WOS:000345279600020 PM 25178985 ER PT J AU Seidl, J Asplund, CA AF Seidl, Jamie Asplund, Chad A. TI Effects of Excessive Endurance Activity on the Heart SO CURRENT SPORTS MEDICINE REPORTS LA English DT Review ID CARDIAC TROPONIN-T; ATRIAL-FIBRILLATION; PHYSICAL-ACTIVITY; VENTRICULAR-ARRHYTHMIAS; CLINICAL-SIGNIFICANCE; MYOCARDIAL FIBROSIS; SPECKLE TRACKING; AMERICAN-COLLEGE; MARATHON RUNNERS; SPORTS-MEDICINE AB Regular moderate exercise confers many cardiovascular and health benefits. Because of this, endurance sports events have become very popular with participation increasing tremendously over the past few years. In conjunction with this increase in popularity and participation, people also have increased the amount that they exercise with many training for and competing in ultraendurance events such as ultradistance running events, iron distance triathlons, or multiday races. This excess endurance activity may appear to increase the risk of cardiac abnormalities, which may increase the risk for long-term morbidity or mortality. While it is known that moderate exercise has benefits to cardiovascular health, ultimately, the long-term cardiac effects of excessive endurance activity are unclear. What is clear, however, is that moderate exercise is beneficial, and to date, the evidence does not support recommending against physical activity. C1 [Seidl, Jamie] Eisenhower Army Med Ctr, Dept Family & Community Med, Ft Gordon, GA USA. [Asplund, Chad A.] Georgia Regents Univ, Augusta, GA 30912 USA. RP Asplund, CA (reprint author), Georgia Regents Univ, Augusta, GA 30912 USA. EM chad.asplund@gmail.com NR 42 TC 1 Z9 1 U1 4 U2 30 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1537-890X EI 1537-8918 J9 CURR SPORT MED REP JI Curr. Sport. Med. Rep. PD NOV-DEC PY 2014 VL 13 IS 6 BP 361 EP 364 DI 10.1249/JSR.0000000000000097 PG 4 WC Sport Sciences SC Sport Sciences GA AT4XD UT WOS:000344944500003 PM 25391090 ER PT J AU Ambrose, J Hampton, LM Fleming-Dutra, KE Marten, C McClusky, C Perry, C Clemmons, NA Mccormic, Z Peik, S Mancuso, J Brown, E Kozak, N Travis, T Lucas, C Fields, B Hicks, L Cersovsky, SB AF Ambrose, J. Hampton, L. M. Fleming-Dutra, K. E. Marten, C. McClusky, C. Perry, C. Clemmons, N. A. Mccormic, Z. Peik, S. Mancuso, J. Brown, E. Kozak, N. Travis, T. Lucas, C. Fields, B. Hicks, L. Cersovsky, S. B. TI Large outbreak of Legionnaires' disease and Pontiac fever at a military base SO EPIDEMIOLOGY AND INFECTION LA English DT Article DE Community outbreaks; Legionella; Legionnaire's disease; legionellosis (Pontiac fever) ID SEQUENCE-BASED SCHEME; LEGIONELLA-PNEUMOPHILA; COMMUNITY OUTBREAK; SOURCE EXPOSURE; UNITED-STATES; SURVEILLANCE; TRANSMISSION; PNEUMONIA; EPIDEMIC; ASSAY AB We investigated a mixed outbreak of Legionnaires' disease (LD) and Pontiac fever (PF) at a military base to identify the outbreak's environmental source as well as known legionellosis risk factors. Base workers with possible legionellosis were interviewed and, if consenting, underwent testing for legionellosis. A retrospective cohort study collected information on occupants of the buildings closest to the outbreak source. We identified 29 confirmed and probable LD and 38 PF cases. All cases were exposed to airborne pathogens from a cooling tower. Occupants of the building closest to the cooling tower were 6.9 [95% confidence interval (CI) 2.2-22.0] and 5.5 (95% CI 2.1-14.5) times more likely to develop LD and PF, respectively, than occupants of the next closest building. Thorough preventive measures and aggressive responses to outbreaks, including searching for PF cases in mixed legionellosis outbreaks, are essential for legionellosis control. C1 [Ambrose, J.; Perry, C.; Clemmons, N. A.; Mccormic, Z.; Peik, S.; Mancuso, J.; Cersovsky, S. B.] US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA. [Hampton, L. M.; Fleming-Dutra, K. E.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30329 USA. [Hampton, L. M.; Fleming-Dutra, K. E.; Brown, E.; Kozak, N.; Travis, T.; Lucas, C.; Fields, B.; Hicks, L.] Ctr Dis Control & Prevent, Resp Dis Branch, Atlanta, GA 30329 USA. [Marten, C.] Michigan Dept Community Hlth, Lansing, MI USA. [McClusky, C.] Michigan Air Natl Guard, Harrison Township, MI USA. RP Hampton, LM (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,MS A-24, Atlanta, GA 30329 USA. EM lhampton@cdc.gov FU U.S. Army Public Health Command; U.S. Centers for Disease Control and Prevention FX Financial support was received from U.S. Army Public Health Command and the U.S. Centers for Disease Control and Prevention. NR 41 TC 4 Z9 4 U1 1 U2 13 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0950-2688 EI 1469-4409 J9 EPIDEMIOL INFECT JI Epidemiol. Infect. PD NOV PY 2014 VL 142 IS 11 BP 2336 EP 2346 DI 10.1017/S0950268813003440 PG 11 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA AT4OZ UT WOS:000344921000011 PM 25267405 ER PT J AU Zhou, J Hoyos, S Sadler, BM AF Zhou, Jun Hoyos, Sebastian Sadler, Brian M. TI Asynchronous Compressed Beamformer for Portable Diagnostic Ultrasound Systems SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Article ID ORTHOGONAL MATCHING PURSUIT; BAND-LIMITED SIGNALS; SPARSE SOLUTION; RECOVERY; NORM AB State-of-the-art portable ultrasound imaging systems employ a small transducer array and a low carrier frequency to fit stringent constraints on power and form factor, and this tends to compromise the ultrasound imaging quality. In this paper, we present a low-complexity low-power asynchronous compressed beamformer (ACB) for portable diagnostic ultrasound. The proposed ACB integrates asynchronous sampling and compressive sensing (CS), and is capable of reducing data conversion power and handling a large data volume at the mixed-signal interface. A high-rate continuous-time ternary encoding (CT-TE) scheme eliminates the need for interpolation filters and coordinate rotation digital computer (CORDIC) units typically used in a conventional architecture. A split-projection least squares (SPLS) signal reconstruction algorithm is applied that replaces high-cost nonlinear signal recovery with a series of low-complexity and independent linear problems. Experiments with measured ultrasound data demonstrate the proposed ACB architecture, and the SPLS reconstruction algorithm achieves 9-fold data compression compared with Nyquist sampling. C1 [Zhou, Jun; Hoyos, Sebastian] Texas A&M Univ, Dept Elect & Comp Engn, College Stn, TX 77843 USA. [Sadler, Brian M.] Army Res Lab, Adelphi, MD USA. RP Zhou, J (reprint author), Texas A&M Univ, Dept Elect & Comp Engn, College Stn, TX 77843 USA. EM ecolejun@tamu.edu RI ZHOU, JUN/L-2838-2015 NR 27 TC 3 Z9 3 U1 2 U2 17 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0885-3010 EI 1525-8955 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD NOV PY 2014 VL 61 IS 11 BP 1791 EP 1801 DI 10.1109/TUFFC.2014.006384 PG 11 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA AT6ZN UT WOS:000345085700003 PM 25389158 ER PT J AU Jensen, PR Wrisberg, CA AF Jensen, Peter R. Wrisberg, Craig A. TI Performance Under Acute Stress: A Qualitative Study of Soldiers' Experiences of Hand-to-Hand Combat SO INTERNATIONAL JOURNAL OF STRESS MANAGEMENT LA English DT Article DE acute stress; hand-to-hand combat; military; performance; phenomenology ID COMPETITION; FIGHTERS; ANXIETY AB The chief aim of this study was to obtain in-depth descriptions of soldiers' first-person experiences of hand-to-hand combat during wartime operations using a stress and coping framework (Lazarus & Folkman, 1984). The results of phenomenological interviews revealed 4 major themes which, based on several participants' own words, were labeled "immediate threat," "flip the switch," "fast," and "adrenaline." It was concluded that the hand-to-hand combat experiences of these soldiers (a) imposed stressors from a variety of sources, (b) required coping responses comprising a swift and accurate interpretation of environmental conditions and rapid deployment of problem-focused strategies, and (c) evoked a constellation of powerful physiological and psychological reactions. Implications of this study for military personnel include the importance of "expecting the unexpected" in seemingly routine yet potentially hazardous combat operations, an emphasis on developing highly automated, problem-focused coping strategies and physical fighting skills, and the need for training in variable and unpredictable environments that demand rapid skill adaptations to context specific stressors. C1 [Jensen, Peter R.; Wrisberg, Craig A.] Univ Tennessee, Dept Kinesiol Recreat & Sport Studies, Knoxville, TN 37996 USA. [Jensen, Peter R.] US Mil Acad, Ctr Enhanced Performance, West Point, NY 10996 USA. RP Jensen, PR (reprint author), US Mil Acad, Ctr Enhanced Performance, 1st Floor Jefferson Hall, West Point, NY 10996 USA. EM pete.jensen1@us.army.mil NR 32 TC 1 Z9 1 U1 3 U2 16 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 1072-5245 EI 1573-3424 J9 INT J STRESS MANAGE JI Int. J. Stress Manage. PD NOV PY 2014 VL 21 IS 4 BP 406 EP 423 DI 10.1037/a0037998 PG 18 WC Psychology, Applied SC Psychology GA AT8BW UT WOS:000345159700006 ER PT J AU Quinn, CM Duran, RM Audet, GN Charkoudian, N Leon, LR AF Quinn, Carrie M. Duran, Rocio M. Audet, Gerald N. Charkoudian, Nisha Leon, Lisa R. TI Cardiovascular and thermoregulatory biomarkers of heat stroke severity in a conscious rat model SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE heat stroke; hemodynamic; thermoregulation; cardiac troponin I ID CARDIAC TROPONIN-I; MYOCARDIAL-INFARCTION; TIME-COURSE; BLOOD-PRESSURE; HEATSTROKE; RESPONSES; STRESS; INJURY; MICE; ANESTHETICS AB Multiorgan failure is a catastrophic consequence of heat stroke (HS) and considered the underlying etiology of mortality. Identifying novel biomarkers capable of predicting the extent of HS-induced organ damage will enhance point-of-care triage and treatment. Conscious male F344 rats (n = 32) were radiotelemetered for continuous core temperature (T-c), heart rate, and arterial pressure measurement. Twenty-two animals were exposed to ambient temperature of 37 degrees C to a maximum T-c of 41.9 +/- 0.1 degrees C. Rats were euthanized at 24 h of recovery for analysis of plasma biomarkers [cardiac troponin I (cTnI), blood urea nitrogen (BUN), alanine aminotransferase (ALT), albumin, glucose] and histology. T-c profiles observed during recovery stratified HS severity into Mild, Moderate, and Severe. Eleven (50%) animals exhibited an acute compensatory hemodynamic response to heat exposure and a monophasic T-c profile consisting of sustained hyperthermia (similar to 1 degrees C). Five (23%) rats displayed hemodynamic challenge and a biphasic T-c profile with rapid return to baseline followed by rebound hyperthermia. All biomarkers were significantly altered from control values (P < 0.05). Four (18%) animals exhibited significant hemodynamic compromise during heat and a triphasic profile characterized by rapid cooling to baseline T-c, rebound hyperthermia, and subsequent hypothermia (similar to 35 degrees C) through 24 h. cTnI showed a 40-fold increase over CON (P < 0.001) and correlated with BUN (r = 0.912) consistent with cardiorenal failure. Hypoglycemia correlated with ALT (r = 0.824) suggestive of liver dysfunction. Histology demonstrated myocardial infarction, renal tubular necrosis, and acute liver necrosis. Two (9%) animals succumbed during HS recovery. This study identified novel biomarkers that predict HS severity and organ damage during acute recovery that could provide clinical significance for identifying key biomarkers of HS pathogenesis. C1 [Quinn, Carrie M.; Duran, Rocio M.; Audet, Gerald N.; Charkoudian, Nisha; Leon, Lisa R.] US Army, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Quinn, CM (reprint author), US Army, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St,Bldg 42, Natick, MA 01760 USA. EM carrie.m.quinn.mil@mail.mil FU Military Operational Medicine Research Program, USAMRMC, MD FX The research was supported by the Military Operational Medicine Research Program, USAMRMC, MD. NR 39 TC 7 Z9 9 U1 1 U2 11 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 EI 1522-1601 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD NOV 1 PY 2014 VL 117 IS 9 BP 971 EP 978 DI 10.1152/japplphysiol.00365.2014 PG 8 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA AT5PT UT WOS:000344995300005 PM 25123200 ER PT J AU Richard, R AF Richard, Reginald TI Burn Therapist Contributions to the American Burn Association and the Journal of Burn Care and Research: A 45th Anniversary Review SO JOURNAL OF BURN CARE & RESEARCH LA English DT Review AB The year 2013 marked the 45th anniversary of American Burn Association (ABA) annual meetings. At this significant juncture, a review of contributions of its members is appropriate to celebrate this milestone. Since the first ABA annual meeting and the initiation of the Journal of Burn Care and Research (JBCR), burn therapists, including both occupational and physical therapists, have grown to become integral members of the ABA, and their contributions among all members are highlighted. A systematic manual review of both ABA annual meeting proceedings and the JBCR was performed. The contributions of burn therapists to the ABA as a whole were classified, cataloged, and hand counted. Areas included: 1) quantifying ABA abstract and JBCR articles on authorship and subject matter, 2) representation on ABA committees; 3) participation in special activities; and 4) other recognitions. Burn therapists comprise 9.7% of ABA members overall. During the course of the first 44 ABA meetings, 8381 abstracts have been presented. Of this number, 634 (7.6%) have been delivered by burn therapists as lead authors. Through the end of 2011, no less than 3207 publications by all disciplines have appeared in JBCR. The vast majority of articles have been written by physicians, followed by doctorate-trained professionals. One hundred-forty therapists have 249 publications (7.8%) to their credit. For both abstracts and articles, the top three subject matter topics have been: scarring, splints and casts, and outcomes. Numerous burn therapists have served as faculty and moderators at ABA annual meetings and on ABA committees including JBCR. Burn therapists have made significant contributions to the JBCR and in support of the ABA and its annual meetings over the past 45 years from the clinical, scientific, and Association perspectives. C1 [Richard, Reginald] US Army, Inst Surg Res, Burn Ctr, Ft Sam Houston, TX 78234 USA. RP Richard, R (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass,Bldg 3611, Ft Sam Houston, TX 78234 USA. NR 12 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X EI 1559-0488 J9 J BURN CARE RES JI J. Burn Care Res. PD NOV-DEC PY 2014 VL 35 IS 6 BP 465 EP 469 DI 10.1097/BCR.0000000000000023 PG 5 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA AT8BO UT WOS:000345159000011 PM 24823340 ER PT J AU Nitzschke, SL Aden, JK Serio-Melvin, ML Shingleton, SK Chung, KK Waters, JA King, BT Burns, CJ Lundy, JB Salinas, J Wolf, SE Cancio, LC AF Nitzschke, Stephanie L. Aden, James K. Serio-Melvin, Maria L. Shingleton, Sarah K. Chung, Kevin K. Waters, J. A. King, Booker T. Burns, Christopher J. Lundy, Jonathan B. Salinas, Jose Wolf, Steven E. Cancio, Leopoldo C. TI Wound Healing Trajectories in Burn Patients and Their Impact on Mortality SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID FLUID RESUSCITATION; EXCISION; PRESSURE; INJURY AB The rate of wound healing and its effect on mortality has not been well described. The objective of this article is to report wound healing trajectories in burn patients and analyze their effects on in-hospital mortality. The authors used software (WoundFlow) to depict burn wounds, surgical results, and healing progression at multiple time points throughout admission. Data for all patients admitted to the intensive care unit with >= 20% TBSA burned were collected retrospectively. The open wound size (OWS), which includes both unhealed burns and unhealed donor sites, was measured. We calculated the rate of wound closure (healing rate), which we defined as the change in OWS/time. We also determined the time delay (DAYS) from day of burn until day on which there was a reduction in OWS < 10%. Data are medians [interquartile range]. There were 38 patients with complete data; 25 had documentation of successful healing (H), and 13 did not (NH). H differed from NH on age (38 years [32-57] vs 63 [51-74]), body mass index (27 [21-28] vs 32 [19-52]), 24-hour fluid resuscitation (12 L [10-16] vs 18 [15-20]), pressors during first 48 hours (72% vs 100%), use of renal replacement therapy (32% vs 92%), and mortality (4% vs 100%). Repeated measures analysis of covariance showed a significant difference between survivors and nonsurvivors on OWS as a function of time (P<.001). Patients with a positive healing rate (+2%/day) after postburn day 20 had 100% survival whereas those with a negative healing rate (-2%/day) had 100% mortality. For H patients, median DAYS was 41 (28-54); median DAYS/TBSA was 1.3 (1.0-1.9). Survivors had a 0.62% drop in OWS/day, or 4.3%/week. In this cohort of patients with >= 20% TBSA, there was a difference in mortality after postburn day 20, between patients with a positive healing rate (+2%/day, 100% survival) and those with a negative healing rate (-2%/day, 100% mortality, P < .05). C1 [Nitzschke, Stephanie L.; Aden, James K.; Serio-Melvin, Maria L.; Shingleton, Sarah K.; Chung, Kevin K.; Waters, J. A.; King, Booker T.; Burns, Christopher J.; Lundy, Jonathan B.; Salinas, Jose; Wolf, Steven E.; Cancio, Leopoldo C.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Burns, Christopher J.] Naval Med Res Unit San Antonio, Ft Sam Houston, TX USA. [Wolf, Steven E.; Cancio, Leopoldo C.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. RP Cancio, LC (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. FU Comprehensive ICU Research Task Area; Comprehensive ICU Research Task Area, U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland FX This study was funded in part by the Comprehensive ICU Research Task Area, U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland. NR 18 TC 3 Z9 3 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X EI 1559-0488 J9 J BURN CARE RES JI J. Burn Care Res. PD NOV-DEC PY 2014 VL 35 IS 6 BP 474 EP 479 DI 10.1097/BCR.0000000000000039 PG 6 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA AT8BO UT WOS:000345159000013 PM 25144807 ER PT J AU Chung, KK Pamplin, JC Batchinsky, AI Hull, JE King, BT Derdak, S Walker, J McNeil, JD Renz, EM Cannon, JW AF Chung, Kevin K. Pamplin, Jeremy C. Batchinsky, Andriy I. Hull, James E. King, Booker T. Derdak, Stephen Walker, Josh McNeil, Jeffrey D. Renz, Evan M. Cannon, Jeremy W. TI Extracorporeal Membrane Oxygenation in a Patient With Refractory Acute Respiratory Distress Syndrome Secondary to Toxic Epidermal Necrolysis SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID STEVENS-JOHNSON-SYNDROME; PULMONARY COMPLICATIONS; POPULATION C1 San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. US Army Inst Surg Res, Ft Sam Houston, TX USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Chung, KK (reprint author), 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. NR 11 TC 0 Z9 0 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X EI 1559-0488 J9 J BURN CARE RES JI J. Burn Care Res. PD NOV-DEC PY 2014 VL 35 IS 6 BP E428 EP E430 DI 10.1097/BCR.0000000000000008 PG 3 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA AT8BO UT WOS:000345159000008 ER PT J AU Sorescu, DC Byrd, EFC Rice, BM Jordan, KD AF Sorescu, Dan C. Byrd, Edward F. C. Rice, Betsy M. Jordan, Kenneth D. TI Assessing the Performances of Dispersion-Corrected Density Functional Methods for Predicting the Crystallographic Properties of High Nitrogen Energetic Salts SO JOURNAL OF CHEMICAL THEORY AND COMPUTATION LA English DT Article ID GENERALIZED GRADIENT APPROXIMATION; X-RAY-STRUCTURE; AUGMENTED-WAVE METHOD; AB-INITIO; EXCHANGE-ENERGY; HYDRAZINIUM SALTS; BASIS-SET; AZIDE; PSEUDOPOTENTIALS; DFT AB Several density functional methods with corrections for long-range dispersion interactions are evaluated for their capabilities to describe the crystallographic lattice properties of a set of 26 high nitrogen-content salts relevant for energetic materials applications. Computations were done using methods that ranged from adding atomatom dispersion corrections with environment-independent and environment-dependent coefficients, to methods that incorporate dispersion effects via dispersion-corrected atom-centered potentials (DCACP), to methods that include nonlocal corrections. Among the functionals tested, the most successful is the nonlocal optPBE-vdW functional of Klimes and Michaelides that predicts unit cell volumes for all crystals of the reference set within the target error range of +/- 3% and gives individual lattice parameters with a mean average percent error of less than 0.81%. The DCACP, Grimmes D3, and Becke and Johnsons exchange-hole (XDM) methods, when used with the BLYP, PBE, and B86b functionals, respectively, are also quite successful at predicting the lattice parameters of the test set. C1 [Sorescu, Dan C.; Jordan, Kenneth D.] US DOE, Natl Energy Technol Lab, Pittsburgh, PA 15236 USA. [Sorescu, Dan C.; Jordan, Kenneth D.] Univ Pittsburgh, Dept Chem & Petr Engn, Pittsburgh, PA 15261 USA. [Byrd, Edward F. C.; Rice, Betsy M.] US Army Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. [Jordan, Kenneth D.] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA. RP Byrd, EFC (reprint author), US Army Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. EM edward.f.byrd2.civ@mail.mil FU DOD Supercomputing Resource Centers (DSRCs); NSF [CHE-1362334] FX We acknowledge with thanks a supercomputing challenge grant at several DOD Supercomputing Resource Centers (DSRCs). Discussions with Dr. Tomas Bucko (Comenius University), Dr. Fabien Tran (Vienna University of Technology), and Dr. Alberto Otero de la Roza (University of California, Merced) on implementation of dispersion interactions in VASP, CP2K, and Quantum Espresso codes are gratefully acknowledged. K.D.J. acknowledges support from NSF through grant number CHE-1362334. NR 84 TC 11 Z9 11 U1 2 U2 24 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1549-9618 EI 1549-9626 J9 J CHEM THEORY COMPUT JI J. Chem. Theory Comput. PD NOV PY 2014 VL 10 IS 11 BP 4982 EP 4994 DI 10.1021/ct5005615 PG 13 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA AT4JI UT WOS:000344905300022 PM 26584381 ER PT J AU Morang, A Waters, JP Stauble, DK AF Morang, Andrew Waters, Jeffrey P. Stauble, Donald K. TI Performance of Submerged Prefabricated Structures to Improve Sand Retention at Beach Nourishment Projects SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE Submerged reef; Cape May; groin; Reef Ball; Beachsaver Reef; beach berm; beach prism; submerged T; Delaware Bay; Wallops Island; Avalon ID CRESTED BREAKWATERS; WAVE-BREAKING AB Submerged breakwaters were examined to evaluate their performance in maintaining the natural beach and retaining beach fill. These included sites where prefabricated concrete reefs, sills, and ball-like reef structures had been deployed. Most of these innovative structures have not performed well in exposed, open-coast, settings unless they were mounted on hard bottom. The Cape May Point, New Jersey, Section 227 demonstration site was used to develop a conceptual analysis model. The project monitored the functional, structural, and economic performance of two innovative prefabricated concrete structures placed at the seaward end of a groin compartment to form an enclosed sill. The project was conducted in conjunction with an ecosystem restoration beach fill to assess if a Beachsaver Reef (TM) and a Double-T sill could help to hold fill sediment in place at the entrance to Delaware Bay, which is influenced by high wave energy and strong tidal currents. The Beachsaver Reef (TM) units appear to be retaining the fill sand, while the Double-T sill settled completely into the bed and is no longer functioning as intended. Settlement and scour of these prefabricated units present the most problems in project performance. Wave attenuation performance is poor when the units settle, and they are better suited to act as a sill to hold sediment on a beach. Guidance is provided from the conceptual model at Cape May Point on the components that are needed to monitor a successful project. Criteria are given on how to evaluate project performance. C1 [Morang, Andrew; Waters, Jeffrey P.; Stauble, Donald K.] US Army Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Morang, A (reprint author), US Army Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. EM Andrew.Morang@usacc.army.mil NR 32 TC 3 Z9 3 U1 2 U2 16 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 EI 1551-5036 J9 J COASTAL RES JI J. Coast. Res. PD NOV PY 2014 VL 30 IS 6 BP 1140 EP 1156 DI 10.2112/JCOASTRES-D-13-00137.1 PG 17 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA AT3IH UT WOS:000344828400004 ER PT J AU Andrews, ES Schoeler, GB Gozalo, AS Carbajal, F Lopez-Sifuentes, V Turell, MJ AF Andrews, Elizabeth S. Schoeler, George B. Gozalo, Alfonso S. Carbajal, Faustino Lopez-Sifuentes, Victor Turell, Michael J. TI Species Diversity, Seasonal, and Spatial Distribution of Mosquitoes (Diptera: Culicidae) Captured in Aotus Monkey-Baited Traps in a Forested Site Near Iquitos, Peru SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE bionomics; mosquito ecology; Amazon Basin ID VENEZUELAN EQUINE ENCEPHALITIS; AMAZON BASIN REGION; RIFT-VALLEY FEVER; ANOPHELES-DARLINGI; VECTOR COMPETENCE; ENVIRONMENTAL-TEMPERATURE; AEDES-TAENIORHYNCHUS; WEST-NILE; VIRUS; TRANSMISSION AB This study was conducted to determine the relative abundance, diversity, seasonal, and vertical distributions of potential mosquito vectors in the Amazon Basin, Peru. A total of 66,097 mosquitoes (50 mosquito species from 12 genera) were collected from May 2001 through March 2002 at a forested site near Iquitos, Peru. Mosquitoes were collected using Aotus nancymae Hershkovitz monkey-baited CDC light traps set for 12-h day and night periods at varying heights (e. g., ground and canopy) in the forest. Of the 12 genera, three accounted for 75% of all mosquitoes collected: Culex (33%), Aedes (23%), and Psorophora (18%). The most prevalent species collected were Aedes serratus (Theobald), Culex pedroi Sirivanakarn & Belkin, Psorophora albigenu (Peryassu), and a combination of Mansonia indubitans Dyar & Shannon and Mansonia titillans (Walker), which accounted for 56% of all mosquitoes captured. In general, mosquitoes were collected more often at night and on the ground. Exceptions include Coquillettidia venezuelensis (Theobald), which were collected in relatively even numbers at both day and night and most Mansonia and some species of Anopheles, which were collected more often in the canopy. Total mosquito populations had two peaks, June-July (Ma. indubitans/titillans and Cq. venezuelensis) and December-January (Ps. albigenu, Cx. pedroi, and Ae. serratus). Observations of the eight most collected mosquitoes indicated that behavioral shifts were not observed between collection months. These data provide a better understanding of the species diversity, population density, and seasonal distribution of potential mosquito vectors within the Amazon Basin region and allow for the development of appropriate vector and disease prevention strategies. C1 [Andrews, Elizabeth S.; Turell, Michael J.] US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Schoeler, George B.; Gozalo, Alfonso S.; Carbajal, Faustino; Lopez-Sifuentes, Victor] US Naval Med Res Unit, Dept Entomol, Callao, Peru. RP Andrews, ES (reprint author), US Army, Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA. EM Elizabeth.s.andrews11.ctr@mail.mil FU Military Infectious Diseases Research Program; Intramural Research Program of the National Institutes of Health, National Institute of Allergy and Infectious Diseases; Comparative Medicine Branch FX We thank the following people from the Peruvian Primatological Project-Enrique Montoya (for his help in setting up this project), Alfredo Cetraro (for daily care of the animals), and Arnulfo Romaina (for his technical assistance). We thank Carlos Tong, Dario Ramirez, and Clever Donayre (U. S. Naval Medical Research Unit No. 6, Callao, Peru) for their assistance in identifying the mosquitoes, and Miguel Vasquez (U. S. Naval Medical Research Unit No. 6) for his support in the establishment of the project as well as on the field collections. We thank James Pecor (Walter Reed Biosystematics Unit, Smithsonian Institution, Washington, DC) for confirming the identity of voucher specimens collected during this study. This research was supported by a grant from the Military Infectious Diseases Research Program and in part by the Intramural Research Program of the National Institutes of Health, National Institute of Allergy and Infectious Diseases, and the Comparative Medicine Branch. NR 36 TC 2 Z9 2 U1 2 U2 16 PU ENTOMOLOGICAL SOC AMER PI ANNAPOLIS PA 3 PARK PLACE, STE 307, ANNAPOLIS, MD 21401-3722 USA SN 0022-2585 EI 1938-2928 J9 J MED ENTOMOL JI J. Med. Entomol. PD NOV PY 2014 VL 51 IS 6 BP 1127 EP 1135 DI 10.1603/ME14058 PG 9 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA AT7NF UT WOS:000345123800005 PM 26309298 ER PT J AU Ostashev, VE Wilson, DK Vecherin, SN Collier, SL AF Ostashev, Vladimir E. Wilson, D. Keith Vecherin, Sergey N. Collier, Sandra L. TI Spatial-temporal coherence of acoustic signals propagating in a refractive, turbulent atmosphere SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID SOUND-PROPAGATION; IMPEDANCE BOUNDARY; WAVE-PROPAGATION; SURFACE; OCEAN; TEMPERATURE; TOMOGRAPHY; SPECTRA; MODEL; SHEAR AB Propagation of acoustic signals above an impedance ground in a refractive, turbulent atmosphere with spatial-temporal fluctuations in temperature and wind velocity is considered. Starting from a parabolic equation, and using the Markov approximation and a locally frozen turbulence hypothesis, closed-form equations for the spatial-temporal statistical moments of arbitrary order of the sound-pressure field are derived. The general theory provides a basis for analysis of many statistical characteristics of broadband and narrowband acoustic signals for different geometries of propagation: line-of-sight propagation, multipath propagation in a refractive atmosphere above an impedance ground, and sound scattering into a refractive shadow zone. As an example of application of this theory, the spatial-temporal coherence of narrowband acoustic signals for line-of-sight propagation is calculated and analyzed. The coherence time of acoustic signals is studied numerically for meteorological conditions ranging from cloudy to sunny conditions, and with light, moderate, and strong wind. The results obtained are compared with available experimental data. C1 [Ostashev, Vladimir E.; Wilson, D. Keith; Vecherin, Sergey N.] US Army Engineer Res & Dev Ctr, Hanover, NH 03755 USA. [Collier, Sandra L.] US Army Res Lab, Adelphi, MD 20783 USA. RP Ostashev, VE (reprint author), US Army Engineer Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03755 USA. EM vladimir.ostashev@noaa.gov RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 FU U.S. Army Engineer Research and Development Center, Geospatial Research and Engineering business area FX This research was sponsored by the U.S. Army Engineer Research and Development Center, Geospatial Research and Engineering business area. Permission to publish was granted by Director, Cold Regions Research and Engineering Laboratory. NR 41 TC 2 Z9 2 U1 0 U2 8 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 EI 1520-8524 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD NOV PY 2014 VL 136 IS 5 BP 2414 EP 2431 DI 10.1121/1.4897311 PG 18 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA AT5NG UT WOS:000344989000013 PM 25373944 ER PT J AU Simmons, B Hill, A Ford, N Ruxrungtham, K Ananworanich, J AF Simmons, Bryony Hill, Andrew Ford, Nathan Ruxrungtham, Kiat Ananworanich, Jintanat TI Prices of second-line antiretroviral treatment for middle-income countries inside versus outside sub-Saharan Africa SO JOURNAL OF THE INTERNATIONAL AIDS SOCIETY LA English DT Meeting Abstract C1 [Simmons, Bryony] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, London, England. [Hill, Andrew] Univ Liverpool, Liverpool L69 3BX, Merseyside, England. [Ford, Nathan] WHO, Dept HIV AIDS, CH-1211 Geneva, Switzerland. [Ruxrungtham, Kiat] Chulalongkorn Univ, Dept Med, Bangkok, Thailand. [Ananworanich, Jintanat] Walter Reed Army Inst Res, Mil HIV Res Program, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INT AIDS SOCIETY PI GENEVA PA AVENUE DE FRANCE 23, GENEVA, 1202, SWITZERLAND SN 1758-2652 J9 J INT AIDS SOC JI J. Int. AIDS Soc. PD NOV PY 2014 VL 17 SU 3 MA P072 BP 77 EP 78 DI 10.7448/IAS.17.4.19604 PG 2 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AT5CR UT WOS:000344961700123 ER PT J AU Korzeniewska, A Cervenka, MC Jouny, CC Perilla, JR Harezlak, J Bergey, GK Franaszczuk, PJ Crone, NE AF Korzeniewska, A. Cervenka, M. C. Jouny, C. C. Perilla, J. R. Harezlak, J. Bergey, G. K. Franaszczuk, P. J. Crone, N. E. TI Ictal propagation of high frequency activity is recapitulated in interictal recordings: Effective connectivity of epileptogenic networks recorded with intracranial EEG SO NEUROIMAGE LA English DT Article DE High frequency oscillations (HFOs); Seizure onset zone; Epileptic network; Epilepsy surgery; Brain mapping; ECoG ID DIRECTED TRANSFER-FUNCTION; EVENT-RELATED CAUSALITY; TEMPORAL-LOBE EPILEPSY; OSCILLATIONS 80-500 HZ; SEIZURE-ONSET; NEOCORTICAL EPILEPSY; CORTICAL STIMULATION; INFORMATION-FLOW; BRAIN STRUCTURES; FOCAL SEIZURES AB Seizures are increasingly understood to arise from epileptogenic networks across which ictal activity is propagated and sustained. In patients undergoing invasive monitoring for epilepsy surgery, high frequency oscillations have been observed within the seizure onset zone during both ictal and interictal intervals. We hypothesized that the patterns by which high frequency activity is propagated would help elucidate epileptogenic networks and thereby identify network nodes relevant for surgical planning. Intracranial EEG recordings were analyzed with a multivariate autoregressive modeling technique (short-time direct directed transfer function-SdDTF), based on the concept of Granger causality, to estimate the directionality and intensity of propagation of high frequency activity (70-175 Hz) during ictal and interictal recordings. These analyses revealed prominent divergence and convergence of high frequency activity propagation at sites identified by epileptologists as part of the ictal onset zone. In contrast, relatively little propagation of this activity was observed among the other analyzed sites. This pattern was observed in both subdural and depth electrode recordings of patients with focal ictal onset, but not in patients with a widely distributed ictal onset. In patients with focal ictal onsets, the patterns of propagation recorded during pre-ictal (up to 5 min immediately preceding ictal onset) and interictal (more than 24 h before and after seizures) intervals were very similar to those recorded during seizures. The ability to characterize epileptogenic networks from interictal recordings could have important clinical implications for epilepsy surgery planning by reducing the need for prolonged invasive monitoring to record spontaneous seizures. (C) 2014 Elsevier Inc. All rights reserved. C1 [Korzeniewska, A.; Cervenka, M. C.; Jouny, C. C.; Bergey, G. K.; Franaszczuk, P. J.; Crone, N. E.] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21287 USA. [Perilla, J. R.] Univ Illinois, Beckman Inst, Urbana, IL 61801 USA. [Perilla, J. R.] Univ Illinois, Dept Phys, Urbana, IL 61801 USA. [Harezlak, J.] Indiana Univ, Richard M Fairbanks Sch Publ Hlth, Dept Biostat, Indianapolis, IN 46202 USA. [Harezlak, J.] Indiana Univ, Sch Med, Indianapolis, IN 46202 USA. [Franaszczuk, P. J.] US Army, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Korzeniewska, A (reprint author), Johns Hopkins Univ, Sch Med, Dept Neurol, 600 N Wolfe St,Meyer 2-147, Baltimore, MD 21287 USA. EM akorzen@jhmi.edu RI Harezlak, Jaroslaw/P-8557-2014; Franaszczuk, Piotr/B-6532-2008; OI Harezlak, Jaroslaw/0000-0002-3070-7686; Franaszczuk, Piotr/0000-0002-5166-4224; Perilla, Juan/0000-0003-1171-6816 FU Epilepsy Foundation [104819, 90036336]; NINDS [R01 NS40596, R01 NS48222, R01 NS75020] FX Supported by: Epilepsy Foundation (Grant # 104819, Award # 90036336) and by NINDS R01 NS40596 (Crone), R01 NS48222 (Bergey) and R01 NS75020 (Jouny) NR 93 TC 7 Z9 7 U1 0 U2 16 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1053-8119 EI 1095-9572 J9 NEUROIMAGE JI Neuroimage PD NOV 1 PY 2014 VL 101 BP 96 EP 113 DI 10.1016/j.neuroimage.2014.06.078 PG 18 WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA AT4SJ UT WOS:000344931800009 PM 25003814 ER PT J AU Hadid, A Moran, DS Evans, RK Fuks, Y Schweitzer, ME Shabshin, N AF Hadid, Amir Moran, Daniel S. Evans, Rachel K. Fuks, Yael Schweitzer, Mark E. Shabshin, Nogah TI Tibial Stress Changes in New Combat Recruits for Special Forces: Patterns and Timing at MR Imaging SO RADIOLOGY LA English DT Article ID LOWER-EXTREMITY; FEMALE RECRUITS; MARROW EDEMA; FOLLOW-UP; FRACTURES; INJURIES; SCINTIGRAPHY; PREVENTION; SOLDIERS; RUNNERS AB Purpose: To characterize the incidence, location, grade, and patterns of magnetic resonance (MR) imaging findings in the tibia in asymptomatic recruits before and after 4-month basic training and to investigate whether MR imaging parameters correlated with pretraining activity levels or with future symptomatic injury. Materials and Methods: This study was approved by three institutional review boards and was conducted in compliance with HIPAA requirements. Volunteers were included in the study after they signed informed consent forms. MR imaging of the tibia of 55 men entering the Israeli Special Forces was performed on recruitment day and after basic training. Ten recruits who did not perform vigorous self-training prior to and during service served as control subjects. MR imaging studies in all recruits were evaluated for presence, type, length, and location of bone stress changes in the tibia. Anthropometric measurements and activity history data were collected. Relationships between bone stress changes, physical activity, and clinical findings and between lesion size and progression were analyzed. Results: Bone stress changes were seen in 35 of 55 recruits (in 26 recruits at time 0 and in nine recruits after basic training). Most bone stress changes consisted of endosteal marrow edema. Approximately 50% of bone stress changes occurred between the middle and distal thirds of the tibia. Lesion size at time 0 had significant correlation with progression. All endosteal findings smaller than 100 mm resolved or did not change, while most findings larger than 100 mm progressed. Of 10 control subjects, one had bone stress changes at time 0, and one had bone stress changes at 4 months. Conclusion: Most tibial bone stress changes occurred before basic training, were usually endosteal, occurred between the middle and distal thirds of the tibia, were smaller than 100 mm, and did not progress. These findings are presumed to represent normal bone remodeling. (C) RSNA, 2014 C1 [Hadid, Amir; Moran, Daniel S.; Fuks, Yael] Chaim Sheba Med Ctr, Heller Inst Med Res, Ramat Gan, Israel. [Hadid, Amir] Tel Aviv Univ, Dept Biomed Engn, IL-69978 Tel Aviv, Israel. [Moran, Daniel S.] Ariel Univ, Dept Physiotherapy, Ariel, Israel. [Evans, Rachel K.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA USA. [Schweitzer, Mark E.] SUNY Stony Brook, Dept Radiol, Stony Brook, NY 11794 USA. [Shabshin, Nogah] Assaf Harofeh Univ, Med Ctr, Dept Imaging, Zerifin, Israel. [Shabshin, Nogah] Hosp Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA. RP Shabshin, N (reprint author), Assaf Harofeh Univ, Med Ctr, Dept Imaging, Zerifin, Israel. EM shabshin@gmail.com RI schweitzer, mark/I-4355-2015 FU Medical Research and Materiel Command [W911QY-08-P-0286] FX Supported in part by the Medical Research and Materiel Command (contract W911QY-08-P-0286). NR 30 TC 0 Z9 0 U1 0 U2 5 PU RADIOLOGICAL SOC NORTH AMERICA PI OAK BROOK PA 820 JORIE BLVD, OAK BROOK, IL 60523 USA SN 0033-8419 J9 RADIOLOGY JI Radiology PD NOV PY 2014 VL 273 IS 2 BP 483 EP 490 DI 10.1148/radiol.14131882 PG 8 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA AT6SS UT WOS:000345069800021 PM 25025463 ER PT J AU Weiss, V Ghoshal, A AF Weiss, Volker Ghoshal, Anindya TI On the search for optimal damage precursors SO STRUCTURAL HEALTH MONITORING-AN INTERNATIONAL JOURNAL LA English DT Article DE Fatigue; crack detection; damage indicators; damage precursors; service life; X-ray diffraction; electrical resistivity; eddy current techniques; metals and composites; material state awareness AB A new approach to predict the service life of critical components via study of damage precursors is emerging and is the topic of this article. To date, most service life predictions are based on measurements of damage indicators and their growth toward criticality or failure, for example, fatigue crack length and material loss due to corrosion or wear. This makes lifetime estimates based on measurements of damage, for example, around half-life, or even at 80% life, difficult and inaccurate. To improve the accuracy and reliability of lifetime prediction, efforts are now underway to determine the state awareness of a critical component during service, based on property characterizations, in addition to the measurements of the direct damage indicators, such as crack length, acoustic emission, ultrasound signals, and eddy current measurements. These characterizations will include indirect damage indicators, that is, precursors and allied or affiliated damage indicators. For affiliated damage indicators, residual stress relaxation or development, phase changes, electrical property (resistivity, dielectric constant, permeability), and microstructural characterization must be considered. The selection of the optimal combination of direct and indirect damage indicators will be application specific. It is proposed to assess the efficacy of damage indicators on the basis of their D-i/D-f versus N-i/N-f, that is, damage ratio versus life fraction curves (referred to as damage indicator ratio curves), searching for indicators with damage indicator ratio curves that best meet the needs of the application. C1 [Weiss, Volker] Syracuse Univ, Syracuse, NY USA. [Ghoshal, Anindya] US Army Res Lab, Prop Div, Vehicle Technol Directorate, Aberdeen Proving Ground, MD USA. RP Ghoshal, A (reprint author), US Army Res Lab RDRL VTP, Prop Div, Vehicle Technol Directorate, 4603 Flare Loop Aberdeen Proving Ground, Aberdeen Proving Ground, MD 21005 USA. EM anindya.ghoshal.civ@mail.mil NR 16 TC 6 Z9 6 U1 2 U2 6 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1475-9217 EI 1741-3168 J9 STRUCT HEALTH MONIT JI Struct. Health Monit. PD NOV PY 2014 VL 13 IS 6 BP 601 EP 608 DI 10.1177/0725513614554732 PG 8 WC Engineering, Multidisciplinary; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA AT9EQ UT WOS:000345231200004 ER PT J AU Owens, BD Campbell, SE Cameron, KL AF Owens, Brett D. Campbell, Scot E. Cameron, Kenneth L. TI Risk Factors for Anterior Glenohumeral Instability SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE shoulder instability; glenoid labrum; epidemiology ID SHOULDER INSTABILITY; UNITED-STATES; HISTORY; YOUNG; EPIDEMIOLOGY; POPULATION; INJURY AB Background: While anterior glenohumeral instability has been shown to be common in young athletes, the risk factors for injury are poorly understood. Purpose/Hypothesis: To determine the modifiable and nonmodifiable risk factors for anterior shoulder instability in a high-risk cohort. The hypothesis was that specific baseline factors would be associated with the subsequent risk of injury. Study Design: Cohort study (prognosis); Level of evidence, 2. Methods: We conducted a prospective cohort study in which 714 young athletes were followed from June 2006 through May 2010. Baseline assessments included a subjective history of instability, physical examination by a sports medicine fellowship-trained orthopaedic surgeon, range of motion, strength with a handheld dynamometer, and bilateral noncontrast shoulder magnetic resonance imaging (MRI). A musculoskeletal radiologist measured glenoid version, glenoid height, glenoid width, glenoid index (height-to-width ratio), glenoid depth, rotator interval (RI) height, RI width, RI area, RI index, and the coracohumeral interval. Subjects were followed to document all acute anterior shoulder instability events during the 4-year follow-up period. The time to anterior shoulder instability event during the follow-up period was the primary outcome of interest. Univariate and multivariable Cox proportional hazards regression models were used to analyze the data. Results: Complete data were available for 714 subjects. During the 4-year surveillance period, there were 39 anterior instability events documented at a mean of 285 days. While we controlled for covariates, significant risk factors of physical examination were as follows: apprehension sign (hazard ratio [HR], 2.96; 95% CI, 1.48-5.90; P = .002) and relocation sign (HR, 4.83; 95% CI, 1.75-13.33; P = .002). Baseline range of motion and strength measures were not associated with subsequent injury. Significant anatomic risk factors on MRI measurement were glenoid index (HR, 8.12; 95% CI, 1.07-61.72; P = .043) and the coracohumeral interval (HR, 1.20; 95% CI, 1.08-1.34; P = .001). Conclusion: This prospective cohort study revealed significant risk factors for shoulder instability in this high-risk population. Physical examination findings of apprehension and relocation were significant while controlling for history of injury. The anatomic variables of significance were not surprisingtall and thin glenoids were at higher risk compared with short and wide glenoids, and the risk of instability increased by 20% for every 1-mm increase in coracohumeral distance. C1 [Owens, Brett D.; Campbell, Scot E.; Cameron, Kenneth L.] US Mil Acad, Keller Army Hosp, West Point, NY 10996 USA. RP Owens, BD (reprint author), Keller Army Hosp, West Point, NY 10996 USA. EM b.owens@us.army.mil OI Cameron, Kenneth/0000-0002-6276-4482 FU Prospective Research Grant from Orthopaedic Research and Education Foundation FX This study was supported by a Prospective Research Grant from Orthopaedic Research and Education Foundation. NR 16 TC 11 Z9 11 U1 3 U2 8 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 EI 1552-3365 J9 AM J SPORT MED JI Am. J. Sports Med. PD NOV PY 2014 VL 42 IS 11 BP 2591 EP 2596 DI 10.1177/0363546514551149 PG 6 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA AT0XU UT WOS:000344658000009 PM 25248922 ER PT J AU Hoest, C Seidman, JC Pan, W Ambikapathi, R Kang, G Kosek, M Knobler, S Mason, CJ Miller, M AF Hoest, Christel Seidman, Jessica C. Pan, William Ambikapathi, Ramya Kang, Gagandeep Kosek, Margaret Knobler, Stacey Mason, Carl J. Miller, Mark CA MAL-ED Network Investigators TI Evaluating Associations Between Vaccine Response and Malnutrition, Gut Function, and Enteric Infections in the MAL-ED Cohort Study: Methods and Challenges SO CLINICAL INFECTIOUS DISEASES LA English DT Article DE vaccines; malnutrition; enteric infections; gut function; MAL-ED ID ORAL ROTAVIRUS VACCINES; ANTIBODY-RESPONSES; POLIO VACCINATION; IMMUNE-SYSTEM; BREAST-MILK; MEASLES; CHILDREN; PROTECTION; COUNTRIES AB Most vaccine assessments have occurred in well-nourished populations of higher socioeconomic status. However, vaccines are often used in populations with high incidences of malnutrition and infections, in whom the effectiveness of some vaccines is inferior for unknown reasons. The degree and extent of vaccine underperformance have not been systematically studied for most vaccines across differing epidemiologic settings. This paper outlines the methods used and challenges associated with measuring immunological responses to oral vaccines against poliovirus and rotavirus, and parenteral vaccines against pertussis, tetanus, and measles in an observational study that monitored daily illness, monthly growth, intestinal inflammation and permeability, pathogen burden, dietary intake, and micronutrient status in children in 8 countries. This evaluation of vaccine response in the context of low- and middle-income countries is intended to address the gaps in knowledge of the heterogeneity in vaccine response in diverse epidemiological settings and the interplay between infections, nutrition, and immune response. C1 [Hoest, Christel; Seidman, Jessica C.; Ambikapathi, Ramya; Knobler, Stacey; Miller, Mark] NIH, Div Int Epidemiol & Populat Studies, Fogarty Int Ctr, Bethesda, MD 20892 USA. [Pan, William] Duke Univ, Dept Environm Sci & Policy, Durham, NC USA. [Pan, William] Duke Univ, Duke Global Hlth Inst, Durham, NC USA. [Kang, Gagandeep] Christian Med Coll & Hosp, Vellore, Tamil Nadu, India. [Kosek, Margaret] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA. [Mason, Carl J.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Miller, M (reprint author), NIH, Div Int Epidemiol & Populat Studies, Fogarty Int Ctr, 16 Ctr Dr, Bethesda, MD 20892 USA. EM millemar@mail.nih.gov RI Strand, Tor/D-9836-2016; OI Strand, Tor/0000-0002-4038-151X; Mohan, Venkata Raghava/0000-0001-5787-7223; Kang, Gagandeep/0000-0002-3656-564X; Lima de Moraes, Milena/0000-0003-1222-8400 FU Bill & Melinda Gates Foundation; Foundation for the National Institutes of Health; National Institutes of Health, Fogarty International Center FX The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development Project (MAL-ED) is carried out as a collaborative project supported by the Bill & Melinda Gates Foundation, the Foundation for the National Institutes of Health, and the National Institutes of Health, Fogarty International Center. NR 44 TC 7 Z9 7 U1 2 U2 10 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD NOV 1 PY 2014 VL 59 SU 4 BP S273 EP S279 DI 10.1093/cid/ciu611 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AT0TJ UT WOS:000344647400011 PM 25305297 ER PT J AU Houpt, E Gratz, J Kosek, M Zaidi, AKM Qureshi, S Kang, G Babji, S Mason, C Bodhidatta, L Samie, A Bessong, P Barrett, L Lima, A Havt, A Haque, R Mondal, D Taniuchi, M Stroup, S McGrath, M Lang, D AF Houpt, Eric Gratz, Jean Kosek, Margaret Zaidi, Anita K. M. Qureshi, Shahida Kang, Gagandeep Babji, Sudhir Mason, Carl Bodhidatta, Ladaporn Samie, Amidou Bessong, Pascal Barrett, Leah Lima, Aldo Havt, Alexandre Haque, Rashidul Mondal, Dinesh Taniuchi, Mami Stroup, Suzanne McGrath, Monica Lang, Dennis CA MAL-ED Network Investigators TI Microbiologic Methods Utilized in the MAL-ED Cohort Study SO CLINICAL INFECTIOUS DISEASES LA English DT Article DE culture; ELISA; enteropathogen; microscopy; PCR ID DIARRHEAGENIC ESCHERICHIA-COLI; HELICOBACTER-PYLORI INFECTION; DEVELOPING-COUNTRIES; INTESTINAL PERMEABILITY; YOUNG-CHILDREN; ENZYME-IMMUNOASSAY; HELMINTH INFECTION; COGNITIVE FUNCTION; GROWTH IMPAIRMENT; PERUVIAN CHILDREN AB A central hypothesis of The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) study is that enteropathogens contribute to growth faltering. To examine this question, the MAL-ED network of investigators set out to achieve 3 goals: (1) develop harmonized protocols to test for a diverse range of enteropathogens, (2) provide quality-assured and comparable results from 8 global sites, and (3) achieve maximum laboratory throughput and minimum cost. This paper describes the rationale for the microbiologic assays chosen and methodologies used to accomplish the 3 goals. C1 [Houpt, Eric; Gratz, Jean; Barrett, Leah; Taniuchi, Mami; Stroup, Suzanne] Univ Virginia, Charlottesville, VA 22908 USA. [Kosek, Margaret] Johns Hopkins Univ, Baltimore, MD USA. [Zaidi, Anita K. M.; Qureshi, Shahida] Aga Khan Univ, Naushahro Feroze, Pakistan. [Kang, Gagandeep; Babji, Sudhir] Christian Med Coll & Hosp, Vellore, Tamil Nadu, India. [Mason, Carl; Bodhidatta, Ladaporn] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Samie, Amidou; Bessong, Pascal] Univ Venda, Thohoyandou, South Africa. [Lima, Aldo; Havt, Alexandre] Univ Fed Ceara, Fortaleza, Ceara, Brazil. [Haque, Rashidul; Mondal, Dinesh] Icddr B, Dhaka, Bangladesh. [McGrath, Monica; Lang, Dennis] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. [Lang, Dennis] Fdn Natl Inst Hlth, Bethesda, MD USA. RP Houpt, E (reprint author), Univ Virginia, Div Infect Dis & Int Hlth, 345 Crispell Dr,MR6 Bldg 1716, Charlottesville, VA 22908 USA. EM erh6k@virginia.edu RI Strand, Tor/D-9836-2016; OI Strand, Tor/0000-0002-4038-151X; Mohan, Venkata Raghava/0000-0001-5787-7223 FU Bill & Melinda Gates Foundation; Foundation for the National Institutes of Health; National Institutes of Health, Fogarty International Center FX The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development Project (MAL-ED) is carried out as a collaborative project supported by the Bill & Melinda Gates Foundation; the Foundation for the National Institutes of Health; and the National Institutes of Health, Fogarty International Center. NR 42 TC 13 Z9 14 U1 2 U2 9 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD NOV 1 PY 2014 VL 59 SU 4 BP S225 EP S232 DI 10.1093/cid/ciu413 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AT0TJ UT WOS:000344647400005 PM 25305291 ER PT J AU Shrestha, PS Shrestha, SK Bodhidatta, L Strand, T Shrestha, B Shrestha, R Chandyo, RK Ulak, M Mason, CJ AF Shrestha, Prakash Sunder Shrestha, Sanjaya Kumar Bodhidatta, Ladaporn Strand, Tor Shrestha, Binob Shrestha, Rita Chandyo, Ram Krishna Ulak, Manjeswori Mason, Carl J. TI Bhaktapur, Nepal: The MAL-ED Birth Cohort Study in Nepal SO CLINICAL INFECTIOUS DISEASES LA English DT Article DE Nepal; MAL-ED; enteric infection; malnutrition; child development ID REPRODUCTIVE AGE; HEALTHY WOMEN; DEFICIENCY; ZINC AB The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study site in Nepal is located in the Bhaktapur municipality, 15 km east of Kathmandu, the capital city of Nepal. Bhaktapur, an ancient city famous for its traditional temples and buildings, is included on UNESCO's World Heritage List and is a major tourist attraction in Nepal. Nepal is a land-locked country located in South Asia between China and India with an area of 147 181 km(2), ranging from sea-level plains to Mount Everest, the world's highest peak. The total population as of the 2011 census was 26.6 million, with an average annual population growth rate of 1.4. Nepal is one of the world's least developed countries and is ranked 157 of 186 in the 2013 Human Development Report; one-third of the Nepali population lives below the poverty line. The current under-5 mortality rate is 54 per 1000 live births, the infant mortality rate is 46 per 1000 live births, and the neonatal mortality rate is 33 per 1000 live births. Vaccine coverage for all Expanded Program on Immunization vaccines is >80%. Among children, the most common diseases contributing to significant morbidity and mortality are acute respiratory infection and dehydration from severe diarrhea. In this article, we report on the geographic, demographic, and socioeconomic features of the Bhaktapur MAL-ED site and describe the data that informed our cohort recruitment strategy. C1 [Shrestha, Prakash Sunder; Shrestha, Rita; Chandyo, Ram Krishna; Ulak, Manjeswori] Tribuhvan Univ, Inst Med, Kathmandu, Nepal. [Shrestha, Sanjaya Kumar; Shrestha, Binob] Walter Reed Armed Forces Res Inst Med Sci, Res Unit, Kathmandu, Nepal. [Bodhidatta, Ladaporn; Mason, Carl J.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Strand, Tor] Univ Bergen, N-5020 Bergen, Norway. RP Shrestha, SK (reprint author), Walter Reed AFRIMS Res Unit Nepal, POB 295, Kathmandu, Nepal. EM shresthask@afrims.org RI Strand, Tor/D-9836-2016 OI Strand, Tor/0000-0002-4038-151X FU Bill & Melinda Gates Foundation; Foundation for the NIH; National Institutes of Health, Fogarty International Center FX The Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development Project (MAL-ED) is carried out as a collaborative project supported by the Bill & Melinda Gates Foundation, the Foundation for the NIH, and the National Institutes of Health, Fogarty International Center. NR 10 TC 12 Z9 12 U1 0 U2 3 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD NOV 1 PY 2014 VL 59 SU 4 BP S300 EP S303 DI 10.1093/cid/ciu459 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AT0TJ UT WOS:000344647400015 PM 25305301 ER PT J AU Post, D AF Post, Douglass TI Product Development with Virtual Prototypes SO COMPUTING IN SCIENCE & ENGINEERING LA English DT Editorial Material C1 US Dept Def, HPCMP, Engineer Res & Devel Ctr, US Army Corps Engineers, Pentagon, DC 20301 USA. RP Post, D (reprint author), US Dept Def, HPCMP, Engineer Res & Devel Ctr, US Army Corps Engineers, Pentagon, DC 20301 USA. EM douglass.post@hpc.mil NR 7 TC 0 Z9 0 U1 1 U2 6 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1521-9615 EI 1558-366X J9 COMPUT SCI ENG JI Comput. Sci. Eng. PD NOV-DEC PY 2014 VL 16 IS 6 BP 4 EP 7 PG 4 WC Computer Science, Interdisciplinary Applications SC Computer Science GA AT3OM UT WOS:000344843900001 ER PT J AU Hu, ZZ Vatamanu, J Borodin, O Bedrov, D AF Hu, Zongzhi Vatamanu, Jenel Borodin, Oleg Bedrov, Dmitry TI A comparative study of alkylimidazolium room temperature ionic liquids with FSI and TFSI anions near charged electrodes SO ELECTROCHIMICA ACTA LA English DT Article ID MOLECULAR-DYNAMICS SIMULATION; DOUBLE-LAYER CAPACITORS; RESTRICTED PRIMITIVE MODEL; ELECTRICAL DOUBLE-LAYER; X-RAY REFLECTIVITY; DIFFERENTIAL CAPACITANCE; ELECTROCHEMICAL PROPERTIES; 2-DIMENSIONAL PERIODICITY; 3-DIMENSIONAL SYSTEMS; POLYMER ELECTROLYTE AB Electric double layer (EDL) structure and capacitance generated by the two series of room temperature ionic liquids containing alkylimidazolium C(n)mim (n = 2,4,6,8) cations and bis(fluorosulfonyl) imide (FSO2)(2)N-, (FSI) or bis(trifluoromethylsulfonyl) imide (CF3SO2)(2)N- (TFSI) anions were studied on flat (basal plane graphite) and atomically corrugated (prismatic plane graphite) charged electrode surfaces using atomistic molecular dynamics simulations. On atomically flat surface, generated EDLs in all systems produced a weakly changing differential capacitance (DC) as a function of electrode potential. However, on atomically rough surfaces, ionic liquids with FSI and TFSI anions show substantially different EDL structures and DC dependence. Unlike [Cnmim][TFSI], which generated a camel-shape DC regardless of the cation alkyl tail length, the [C(n)mim][FSI] showed a transition from a bell-shape to a camel-shape DC upon increase of the cation alkyl tail length. Analysis of contributions from rearrangement and reorientation of cations and anions indicated that the ability of the FSI anion to respond to changes in electrode potential is the primary driving force for such behavior. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Hu, Zongzhi; Vatamanu, Jenel; Bedrov, Dmitry] Univ Utah, Dept Mat Sci & Engn, Salt Lake City, UT 84112 USA. [Borodin, Oleg] US Army, Res Lab, Electrochem Branch, Sensor & Electron Devices Directorate, Adelphi, MD USA. RP Vatamanu, J (reprint author), Univ Utah, Dept Mat Sci & Engn, 122 South Cent Campus Dr,Room 304, Salt Lake City, UT 84112 USA. EM jenel.vatamanu@utah.edu RI Borodin, Oleg/B-6855-2012; Vatamanu, Jenel/I-7638-2012 OI Borodin, Oleg/0000-0002-9428-5291; Vatamanu, Jenel/0000-0003-0825-1608 FU Army Research Laboratory [W911NF-12-2-0023] FX This research was sponsored by the Army Research Laboratory under Cooperative Agreement Number W911NF-12-2-0023. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 117 TC 15 Z9 15 U1 9 U2 63 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0013-4686 EI 1873-3859 J9 ELECTROCHIM ACTA JI Electrochim. Acta PD NOV 1 PY 2014 VL 145 BP 40 EP 52 DI 10.1016/j.electacta.2014.08.072 PG 13 WC Electrochemistry SC Electrochemistry GA AS3UQ UT WOS:000344203900006 ER PT J AU Platteborze, PL Kippenberger, DJ Martin, TM AF Platteborze, Peter L. Kippenberger, Donald J. Martin, Thomas M. TI Unauthorized Drug Use in the US Army Based on Medical Review Officer Evaluations SO JOURNAL OF ANALYTICAL TOXICOLOGY LA English DT Article AB This article examines the US Army's Medical Review Officer (MRO) drug positive urinalysis evaluations from 2009 through 2012. We retrospectively analyzed nearly 70,000 MRO results by year, drug and Army component. Of the MRO reviewable positive results, the Army's unauthorized drug positive rate was 22.21%. The component rates were 20.81, 24.17 and 26.09% for the Active Duty, Reserve and National Guard, respectively. By drug, the average unauthorized rates over these 4 years were 13.78% for oxycodone, 24.62% oxymorphone, 18.56% d-amphetamine, 98.04% d-methamphetamine, 21.97% codeine, 45.21% morphine and 100% steroids. In 2012 testing began for hydrocodone and hydromorphone and their unauthorized rates were 12.32 and 15.04%, respectively. The Army's unauthorized drug positive rate peaked in 2012 when it increased over 44% from the previous year. The 2012 rates in decreasing order were steroids > d-methamphetamine > morphine > oxymorphone > oxycodone > codeine > d-amphetamine > hydromorphone > hydrocodone. This comprehensive analysis showed that the majority of the Army's MRO reviews were associated with the use of authorized prescriptions; however, there appears to be significant abuse of oxycodone and d-amphetamine. C1 [Platteborze, Peter L.] Brooke Army Med Ctr, DPALS, JBSA, Ft Sam Houston, TX 78234 USA. [Kippenberger, Donald J.] USAMEDCOM, JPSA, Ft Sam Houston, TX USA. [Martin, Thomas M.] Pentagon Off Secretary Def Personnel & Readiness, Washington, DC USA. RP Platteborze, PL (reprint author), Brooke Army Med Ctr, DPALS, JBSA, Ft Sam Houston, TX 78234 USA. EM peter.platteborze@us.army.mil NR 10 TC 2 Z9 2 U1 0 U2 7 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0146-4760 EI 1945-2403 J9 J ANAL TOXICOL JI J. Anal. Toxicol. PD NOV-DEC PY 2014 VL 38 IS 9 BP 653 EP 659 DI 10.1093/jat/bku079 PG 7 WC Chemistry, Analytical; Toxicology SC Chemistry; Toxicology GA AT0DA UT WOS:000344606000005 PM 25002456 ER PT J AU Reen, BP Schmehl, KJ Young, GS Lee, JA Haupt, SE Stauffer, DR AF Reen, Brian P. Schmehl, Kerrie J. Young, George S. Lee, Jared A. Haupt, Sue Ellen Stauffer, David R. TI Uncertainty in Contaminant Concentration Fields Resulting from Atmospheric Boundary Layer Depth Uncertainty SO JOURNAL OF APPLIED METEOROLOGY AND CLIMATOLOGY LA English DT Article DE Boundary layer; Dispersion; Ensembles; Hazardous release modeling; Mesoscale models; Tracers ID HETEROGENEOUS SOIL-MOISTURE; SOUTHERN GREAT-PLAINS; PART I; DISPERSION MODELS; ENSEMBLE VARIANCE; DATA ASSIMILATION; AIR-QUALITY; WRF MODEL; MESOSCALE; TRANSPORT AB The relationship between atmospheric boundary layer (ABL) depth uncertainty and uncertainty in atmospheric transport and dispersion (ATD) simulations is investigated by examining profiles of predicted concentrations of a contaminant. Because ensembles are an important method for quantifying uncertainty in ATD simulations, this work focuses on the utilization and analysis of ensemble members' ABL structures for ATD simulations. A 12-member physics ensemble of meteorological model simulations drives a 12-member explicit ensemble of ATD simulations. The relationship between ABL depth and plume depth is investigated using ensemble members, which vary both the relevant model physics and the numerical methods used to diagnose ABL depth. New analysis methods are used to analyze ensemble output within an ABL-depth relative framework. Uncertainty due to ABL depth calculation methodology is investigated via a four-member mini-ensemble. When subjected to a continuous tracer release, concentration variability among the ensemble members is largest near the ABL top during the daytime, apparently because of uncertainty in ABL depth. This persists to the second day of the simulation for the 4-member diagnosis mini-ensemble, which varies only the ABL depth, but for the 12-member physics ensemble the concentration variability is large throughout the daytime ABL. This suggests that the increased within-ABL concentration variability on the second day is due to larger differences among the ensemble members' predicted meteorological conditions rather than being solely due to differences in the ABL depth diagnosis methods. This work demonstrates new analysis methods for the relationship between ABL depth and plume depth within an ensemble framework and provides motivation for directly including ABL depth uncertainty from a meteorological model into an ATD model. C1 [Reen, Brian P.] US Army Res Lab, Battlefield Environm Div, Adelphi, MD 20783 USA. [Reen, Brian P.; Young, George S.; Lee, Jared A.; Haupt, Sue Ellen; Stauffer, David R.] Penn State Univ, Dept Meteorol, University Pk, PA 16802 USA. [Schmehl, Kerrie J.; Lee, Jared A.; Haupt, Sue Ellen] Penn State Univ, Appl Res Lab, University Pk, PA 16802 USA. [Lee, Jared A.; Haupt, Sue Ellen] Natl Ctr Atmospher Res, Res Applicat Lab, Boulder, CO 80307 USA. RP Reen, BP (reprint author), US Army Res Lab, Battlefield Environm Div, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM brian.p.reen.civ@mail.mil FU Defense Threat Reduction Agency [W911NF-06-C-0162, DTRA01-03-D-0010-0012] FX We acknowledge Doug Henn of Sage Management for assistance with SCIPUFF and Walter Kolczynski for helpful discussions. We thank two anonymous reviewers whose comments led to the improvement of this manuscript. This research was supported by the Defense Threat Reduction Agency under Contracts W911NF-06-C-0162 and DTRA01-03-D-0010-0012 under the supervision of John Hannan. NR 51 TC 2 Z9 2 U1 0 U2 5 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1558-8424 EI 1558-8432 J9 J APPL METEOROL CLIM JI J. Appl. Meteorol. Climatol. PD NOV PY 2014 VL 53 IS 11 BP 2610 EP 2626 DI 10.1175/JAMC-D-13-0262.1 PG 17 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA AT4UL UT WOS:000344938500012 ER PT J AU Farina, EK Austin, KG Lieberman, HR AF Farina, Emily K. Austin, Krista G. Lieberman, Harris R. TI Concomitant Dietary Supplement and Prescription Medication Use Is Prevalent among US Adults with Doctor-Informed Medical Conditions SO JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS LA English DT Article DE Dietary supplements; Prescription medications; Interactions; Chronic disease; Medical conditions ID ALTERNATIVE MEDICINE; UNITED-STATES; PRIMARY-CARE; DRUG-INTERACTIONS; OLDER-ADULTS; COMPLEMENTARY AB Information on patterns of concomitant dietary supplement (DS) and prescription medication (PM) use among US adults is limited. Thus, the prevalence of concomitant DS and PM use as a function of doctor-informed medical conditions (DIMC) was determined in a cross-sectional, observational study of a nationally representative sample of noninstitutionalized, civilian adults aged >= 20 years in the United States (N=9,950) from the 2005-2008 National Health and Nutrition Examination Survey (NHANES). Data were weighted for the complex, multistage, probability sampling design. Approximately one third (34.3%) of all US adults reported concomitant DS and PM use (approximately one in three adults). The prevalence of use was significantly higher among those with vs without a DIMC (47.3% vs 17.3%). Adults with a DIMC were more than two and a half times more likely to concomitantly use DS and PM than adults without a DIMC, after adjustment for sex, age, education, and household income. Multivitamin plus other ingredient(s), followed by antacids and multivitamin plus botanical ingredient(s), were the most prevalent DS categories used with a PM among those with and without a DIMC. The most prevalent PM categories used with a DS were cardiovascular agents (among those with a DIMC) and hormones (among those without a DIMC). These findings demonstrate that presence of a DIMC may be a risk factor for concomitant DS and PM use among US adults. Multivitamins containing nonvitamin or mineral ingredients are more commonly used than standard multivitamins with PM by US adults. This may be an emerging trend that warrants further consideration. C1 [Farina, Emily K.; Austin, Krista G.] Oak Ridge Associated Univ, Oak Ridge Inst Sci & Educ, Belcamp, MD USA. [Farina, Emily K.; Austin, Krista G.; Lieberman, Harris R.] US Army, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. RP Farina, EK (reprint author), US Army, Environm Med Res Inst, Bldg 42,Kansas St, Natick, MA 01760 USA. EM emily.k.farina.ctr@mail.mil FU US Army Medical Research and Material Command (USAMRMC); Department of Defense Center Alliance for Dietary Supplement Research FX This work was supported by the US Army Medical Research and Material Command (USAMRMC), Department of Defense Center Alliance for Dietary Supplement Research, and an appointment to the Postgraduate Research Participation Program administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and USAMRMC. The opinions or assertions contained herein are the private views of the author and are not to be construed as official or as reflecting the views of the Army or the Department of Defense. Human subjects participated after giving their free and informed voluntary consent. The investigators adhered to the policies for protection of human subjects as prescribed in Army Regulation 70-25, and the research was conducted in adherence with the provisions of 32 CFR Part 219. Citations of commercial organizations and trade names in this report do not constitute an official Department of the Army endorsement or approval of the products or services of these organizations. Approved for public release. NR 29 TC 8 Z9 8 U1 2 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 2212-2672 EI 2212-2680 J9 J ACAD NUTR DIET JI J. Acad. Nutr. Diet. PD NOV PY 2014 VL 114 IS 11 BP 1784 EP + DI 10.1016/j.jand.2014.01.016 PG 9 WC Nutrition & Dietetics SC Nutrition & Dietetics GA AS8CE UT WOS:000344477100012 PM 24703929 ER PT J AU Torres, LN Sondeen, JL Dubick, MA Torres, I AF Torres, Luciana N. Sondeen, Jill L. Dubick, Michael A. Torres Filho, Ivo TI Systemic and microvascular effects of resuscitation with blood products after severe hemorrhage in rats SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Microcirculation; packed red blood cells; intravital microscopy; ROTEM; plasma proteins; rats ID CRYOPRESERVED DEGLYCEROLIZED BLOOD; ENDOTHELIAL SURFACE-LAYER; WHOLE-BLOOD; INTRAVITAL MICROSCOPY; CELL-ADHESION; IN-VIVO; GLYCOCALYX; SHOCK; TRAUMA; PLASMA AB BACKGROUND: Severe hemorrhage is associated with the disruption of the endothelial glycocalyx (EG), a key component of the endothelium. The effects of blood components on the EG are unknown. The present study furthers our investigations into the effects of resuscitation with blood products on the skeletal muscle microcirculation of hemorrhaged rats, focusing on packed red blood cells (PRBCs) or fresh whole blood (FWB). METHODS: Rats were bled 40% of total blood volume and resuscitated with 1:1 PRBC/lactated Ringer's solution (LR), 1:1 washed PRBC (wPRBC)/LR, FWB or LR only. Sham animals were subjected to all procedures except hemorrhage and resuscitation. EG thickness, blood flow, and microvascular permeability were studied using intravital microscopy. Hemodynamics and coagulation tests (rotational thromboelastometry) were performed. RESULTS: After severe hemorrhage, EG and permeability were restored to sham levels in the PRBC/LR and FWB groups, but not in the wPRBC/LR or LR groups. Clotting time was longer and clot elasticity and firmness were reduced in wPRBC/LR and LR, but not in FWB or PRBC/LR groups when compared with sham. CONCLUSION: Resuscitation with FWB or PRBC/LR was superior in reversing coagulopathy, restoring EG and permeability changes following hemorrhage, compared with wPRBC/LR or LR alone. As wPRBC/LR did not improve EG and permeability, these data suggest that the removal of residual plasma protein from wPRBC or resuscitation with a protein-free solution (LR) is not able to improve microcirculation and coagulation functions in this severe hemorrhage model. Copyright (C) 2014 by Lippincott Williams & Wilkins C1 [Torres, Luciana N.; Sondeen, Jill L.; Dubick, Michael A.; Torres Filho, Ivo] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA. RP Torres, LN (reprint author), US Army Inst Surg Res, 3698 Chambers Pass,BHT 2,Room 281-3, Jbsa Ft Sam Houston, TX 78234 USA. EM luciana.n.torres.ctr@mail.mil FU US Army Medical Research and Materiel Command FX This study was supported by the US Army Medical Research and Materiel Command. I.T.F. is employed by Universidade do Estado do Rio de Janeiro and Premier Consulting & Management Services, Inc. NR 35 TC 5 Z9 5 U1 1 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD NOV PY 2014 VL 77 IS 5 BP 716 EP 723 DI 10.1097/TA.0000000000000448 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA AT1OB UT WOS:000344702300013 ER PT J AU Malherbe, DC Pissani, F Sather, DN Guo, BW Pandey, S Sutton, WF Stuart, AB Robins, H Park, B Krebs, SJ Schuman, JT Kalams, S Hessell, AJ Haigwood, NL AF Malherbe, Delphine C. Pissani, Franco Sather, D. Noah Guo, Biwei Pandey, Shilpi Sutton, William F. Stuart, Andrew B. Robins, Harlan Park, Byung Krebs, Shelly J. Schuman, Jason T. Kalams, Spyros Hessell, Ann J. Haigwood, Nancy L. TI Envelope Variants Circulating as Initial Neutralization Breadth Developed in Two HIV-Infected Subjects Stimulate Multiclade Neutralizing Antibodies in Rabbits SO JOURNAL OF VIROLOGY LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; BINDING-SITE ANTIBODIES; STRUCTURE-BASED DESIGN; B-CELL RECEPTORS; MONOCLONAL-ANTIBODIES; PROTEIN IMMUNOGENS; VACCINE EFFICACY; STRUCTURAL BASIS; CO-IMMUNIZATION; RESPONSES AB Identifying characteristics of the human immunodeficiency virus type 1 (HIV-1) envelope that are effective in generating broad, protective antibodies remains a hurdle to HIV vaccine design. Emerging evidence of the development of broad and potent neutralizing antibodies in HIV-infected subjects suggests that founder and subsequent progeny viruses may express unique antigenic motifs that contribute to this developmental pathway. We hypothesize that over the course of natural infection, B cells are programmed to develop broad antibodies by exposure to select populations of emerging envelope quasispecies variants. To test this hypothesis, we identified two unrelated subjects whose antibodies demonstrated increasing neutralization breadth against a panel of HIV-1 isolates over time. Full-length functional env genes were cloned longitudinally from these subjects from months after infection through 2.6 to 5.8 years of infection. Motifs associated with the development of breadth in published, cross-sectional studies were found in both subjects. We compared the immunogenicity of envelope vaccines derived from time points obtained during and after broadening of neutralization activity within these subjects. Rabbits were coimmunized four times with selected multiple gp160 DNAs and gp140-trimeric envelope proteins. The affinity of the polyclonal response increased as a function of boosting. The most rapid and persistent neutralization of multiclade tier 1 viruses was elicited by envelopes that were circulating in plasma at time points prior to the development of 50% neutralization breadth in both human subjects. The breadth elicited in rabbits was not improved by exposure to later envelope variants. These data have implications for vaccine development in describing a target time point to identify optimal envelope immunogens. IMPORTANCE Vaccine protection against viral infections correlates with the presence of neutralizing antibodies; thus, vaccine components capable of generating potent neutralization are likely to be critical constituents in an effective HIV vaccine. However, vaccines tested thus far have elicited only weak antibody responses and very modest, waning protection. We hypothesized that B cells develop broad antibodies by exposure to the evolving viral envelope population and tested this concept using multiple envelopes from two subjects who developed neutralization breadth within a few years of infection. We compared different combinations of envelopes from each subject to identify the most effective immunogens and regimens. In each subject, use of HIV envelopes circulating during the early development and maturation of breadth generated more-potent antibodies that were modestly cross neutralizing. These data suggest a new approach to identifying envelope immunogens that may be more effective in generating protective antibodies in humans. C1 [Malherbe, Delphine C.; Pissani, Franco; Guo, Biwei; Pandey, Shilpi; Sutton, William F.; Park, Byung; Hessell, Ann J.; Haigwood, Nancy L.] Oregon Hlth & Sci Univ, Oregon Natl Primate Res Ctr, Beaverton, OR 97006 USA. [Pissani, Franco; Krebs, Shelly J.] US Mil Acad, HIV Res Program, Silver Spring, MD USA. [Pissani, Franco; Krebs, Shelly J.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Sather, D. Noah; Stuart, Andrew B.] Seattle Biomed, Seattle, WA USA. [Robins, Harlan] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Schuman, Jason T.] GE Healthcare, Life Sci, Piscataway, NJ USA. [Kalams, Spyros] Vanderbilt Univ, Nashville, TN 37235 USA. [Haigwood, Nancy L.] Oregon Hlth & Sci Univ, Dept Mol Microbiol & Immunol, Beaverton, OR USA. RP Haigwood, NL (reprint author), Oregon Hlth & Sci Univ, Oregon Natl Primate Res Ctr, Beaverton, OR 97006 USA. EM haigwoon@ohsu.edu FU National Institutes of Health [P01AI078064, P51 OD-011092] FX This work was supported by National Institutes of Health grants P01AI078064 and P51 OD-011092. NR 88 TC 14 Z9 14 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X EI 1098-5514 J9 J VIROL JI J. Virol. PD NOV PY 2014 VL 88 IS 22 BP 12949 EP 12967 DI 10.1128/JVI.01812-14 PG 19 WC Virology SC Virology GA AT3CG UT WOS:000344812500003 PM 25210191 ER PT J AU Carson, RA Sahni, O AF Carson, R. A. Sahni, O. TI Numerical investigation of propellant leak methods in large-caliber cannons for blast overpressure attenuation SO SHOCK WAVES LA English DT Article DE Blast overpressure attenuation; Muzzle; Cannon; Propellant leak; ALE3D ID MUZZLE BLAST; PRESSURE AB In this study, we numerically investigate a novel means to reduce blast overpressure to the rear of a muzzle-loaded cannon. Reduction in blast overpressure, and thus peak overpressure, leads to an increase in the number of allowed rounds that can be fired over a given period of time for the crew manning the system. New propellant leak methods are studied using numerical simulations, where the propellant gas is intentionally allowed to leak in front of the projectile into the precursor region (while the projectile is still in the bore). This is done through the addition of a bulge or leak channels in the tube. The focus of this work is on a large-caliber muzzle-loaded cannon at (1,422 angular mils) elevation and with firing done at the max zone with the round and charge conditioned to ambient. We employ a hydrocode (ALE3D) to predict the blast overpressure for three types of geometries comprising five geometric configurations in total. These include one baseline configuration (i.e., with no modification) as well as four additional configurations with bulges and channels to allow propellant leak. The leaking of propellant gas into the precursor region leads to changes in the flow field associated with the precursor. In the case of channels, propellant leak results in a significantly reduced exit pressure ratio during projectile separation, and thereby, leading to a weaker primary blast wave. This in turn attenuates the peak overpressure to the rear of the muzzle without the aid of a muzzle device. For the channel leak method, at one monitored location, with the largest peak overpressure, a reduction of about 38 % was observed in peak overpressure as compared to the baseline case. C1 [Carson, R. A.] US Army, ARDEC Benet Labs, Watervliet Arsenal, Watervliet, NY 12189 USA. [Sahni, O.] Rensselaer Polytech Inst, Mech Aerosp & Nucl Engn Dept, Troy, NY 12180 USA. RP Carson, RA (reprint author), US Army, ARDEC Benet Labs, Watervliet Arsenal, Watervliet, NY 12189 USA. EM robert.a.carson26.civ@mail.mil; sahni@rpi.edu FU US Army Armament Research, Development and Engineering Center (ARDEC) Science Fellowship FX The authors would like to acknowledge several individuals for their contributions to this work. We would like to thank Andy Anderson, Willy Moss, and Sam Schofield from the Lawrence Livermore National Laboratory for their help in the development of the input deck for the ALE3D code and understanding the underlying discretization used in the code. We would also like to thank Don Carlucci at Benet Laboratories and the support of US Army Armament Research, Development and Engineering Center (ARDEC) Science Fellowship. The ARDEC Science Fellowship to the lead author was essential for this work. Additionally, we would like to thank Dr. Robert Dillon, Chief Scientist at Benet Laboratories, for his technical consultation in reviewing this work as well as Dan Crayon, Supervisor of the Armaments Health Monitoring and Mechatronics Branch at Benet Laboratories. The authors would also like to thank the reviewers and editor for their suggestions to improve the overall quality of the paper. NR 19 TC 5 Z9 5 U1 0 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0938-1287 EI 1432-2153 J9 SHOCK WAVES JI Shock Waves PD NOV PY 2014 VL 24 IS 6 BP 625 EP 638 DI 10.1007/s00193-014-0522-7 PG 14 WC Mechanics SC Mechanics GA AT2PF UT WOS:000344776000007 ER PT J AU Cho, H Bae, S Choi, KK Lamb, D Yang, RJ AF Cho, Hyunkyoo Bae, Sangjune Choi, K. K. Lamb, David Yang, Ren-Jye TI An efficient variable screening method for effective surrogate models for reliability-based design optimization SO STRUCTURAL AND MULTIDISCIPLINARY OPTIMIZATION LA English DT Article DE Variable screening; RBDO; Surrogate model; Output variance; 1-D Surrogate model; Partial output variance; Hypothesis testing; Univariate dimension reduction method ID METAMODELING TECHNIQUES; ENGINEERING DESIGN; SENSITIVITY; UNCERTAINTY AB In the reliability-based design optimization (RBDO) process, surrogate models are frequently used to reduce the number of simulations because analysis of a simulation model takes a great deal of computational time. On the other hand, to obtain accurate surrogate models, we have to limit the dimension of the RBDO problem and thus mitigate the curse of dimensionality. Therefore, it is desirable to develop an efficient and effective variable screening method for reduction of the dimension of the RBDO problem. In this paper, requirements of the variable screening method for deterministic design optimization (DDO) and RBDO are compared, and it is found that output variance is critical for identifying important variables in the RBDO process. An efficient approximation method based on the univariate dimension reduction method (DRM) is proposed to calculate output variance efficiently. For variable screening, the variables that induce larger output variances are selected as important variables. To determine important variables, hypothesis testing is used in this paper so that possible errors are contained in a user-specified error level. Also, an appropriate number of samples is proposed for calculating the output variance. Moreover, a quadratic interpolation method is studied in detail to calculate output variance efficiently. Using numerical examples, performance of the proposed method is verified. It is shown that the proposed method finds important variables efficiently and effectively. C1 [Cho, Hyunkyoo; Bae, Sangjune; Choi, K. K.] Univ Iowa, Dept Mech & Ind Engn, Iowa City, IA 52242 USA. [Lamb, David] US Army RDECOM TARDEC, Warren, MI 48397 USA. [Yang, Ren-Jye] Ford Motor Co, Res & Adv Engn, Dearborn, MI 48121 USA. RP Choi, KK (reprint author), Univ Iowa, Dept Mech & Ind Engn, Iowa City, IA 52242 USA. EM kkchoi@engineering.uiowa.edu RI Choi, Kyung/B-1512-2008 OI Choi, Kyung/0000-0003-2384-6220 FU Automotive Research Center - U.S. Army TARDEC; National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [R32-2008-000-10161-0] FX Research is supported by the Automotive Research Center, which is sponsored by the U.S. Army TARDEC. This research was also partially supported by the World Class University Program through a National Research Foundation of Korea (NRF) grant funded by the Ministry of Education, Science and Technology (Grant Number R32-2008-000-10161-0 in 2009). These supports are greatly appreciated. The authors also express appreciation to Lei Shi of Ford Motor Company for his modeling help and consultation. NR 38 TC 3 Z9 5 U1 4 U2 13 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1615-147X EI 1615-1488 J9 STRUCT MULTIDISCIP O JI Struct. Multidiscip. Optim. PD NOV PY 2014 VL 50 IS 5 BP 717 EP 738 DI 10.1007/s00158-014-1096-9 PG 22 WC Computer Science, Interdisciplinary Applications; Engineering, Multidisciplinary; Mechanics SC Computer Science; Engineering; Mechanics GA AS9EA UT WOS:000344544700001 ER PT J AU Hanrahan, BM Misra, S Beyaz, MI Feldman, JH Waits, CM Ghodssi, R AF Hanrahan, Brendan M. Misra, Saswat Beyaz, Mustafa I. Feldman, Jeremy H. Waits, Christopher M. Ghodssi, Reza TI An Adhesion-Dominated Rolling Friction Regime Unique to Micro-scale Ball Bearings SO TRIBOLOGY LETTERS LA English DT Article DE Vapor-phase lubrication; Silicon; Ball bearings; Adhesive wear; MEMS ID MICROBALL BEARINGS; MECHANISM; SURFACE; RANGE AB We demonstrate that micro-scale rolling bearings exhibit friction and wear properties markedly different from their macro-scale counterparts. A microfabricated testing platform uses variable rolling element diameters or vapor-phase lubricated interfaces to independently test friction force with varying contact area and surface energy. A linear, consistent, relationship between friction force and contact area is observed among different rolling element diameters. When surface free energy is altered through the introduction of vapor-phase lubrication, an 83 % decrease in friction is observed. When coupled with observed ball material adhered to the raceway, there is strong evidence for adhesion-dominated rolling friction regime at the micro-scale. C1 [Hanrahan, Brendan M.; Waits, Christopher M.] US Army Res Lab, Adelphi, MD 20783 USA. [Misra, Saswat; Feldman, Jeremy H.; Ghodssi, Reza] Univ Maryland, Elect & Comp Engn Dept, Syst Res Inst, College Pk, MD 20704 USA. [Beyaz, Mustafa I.] Antalya Int Univ, Dept Elect & Elect Engn, Antalya, Turkey. RP Hanrahan, BM (reprint author), Oak Ridge Associated Univ Fellowship Program, Oak Ridge, TN 37830 USA. EM brendan.m.hanrahan@gmail.com; ghodssi@umd.edu FU U.S. National Science Foundation [0901411] FX This work was supported by the U.S. National Science Foundation under award no. 0901411. We would also like to acknowledge the Maryland Nanocenter and the U. S. Army Research Laboratory Cleanroom Staff. NR 23 TC 2 Z9 2 U1 1 U2 8 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1023-8883 EI 1573-2711 J9 TRIBOL LETT JI Tribol. Lett. PD NOV PY 2014 VL 56 IS 2 BP 215 EP 221 DI 10.1007/s11249-014-0401-5 PG 7 WC Engineering, Chemical; Engineering, Mechanical SC Engineering GA AT0FP UT WOS:000344612900004 ER PT J AU DeRosa, R Musser, JE Rooks, VJ McPherson, J McMann, LP AF DeRosa, Raffaella Musser, John E. Rooks, Veronica J. McPherson, John McMann, Leah P. TI Upper Urinary Tract Abnormalities: A Case of Bilateral Kidneys Within a Left-sided Omphalocele SO UROLOGY LA English DT Article ID OEIS COMPLEX AB Children with omphalocele, exstrophy, imperforate anus, and spinal defects complex present with the most severe form of birth defects in the exstrophy-epispadias spectrum. Prenatal diagnosis is difficult, but improved survival over the past several decades makes understanding the potential anatomic manifestations imperative for expeditious and appropriate surgical care. The upper urinary tract is often normal in children with omphalocele, exstrophy, imperforate anus, and spinal defects complex, but malposition of one of the kidneys has previously been reported. We present the first case of bilateral kidney herniation into the omphalocele sac. Published by Elsevier Inc. C1 [DeRosa, Raffaella] Tripler Army Med Ctr, Dept Surg, Div Urol, Honolulu, HI 96859 USA. Mem Sloan Kettering Canc Ctr, Dept Urol Oncol, New York, NY 10021 USA. Dept Surg, Urol Serv, New York, NY USA. Tripler Army Med Ctr, Dept Radiol, Honolulu, HI 96859 USA. Womack Army Med Ctr, Dept Radiol, Ft Bragg, NC USA. RP DeRosa, R (reprint author), Tripler Army Med Ctr, Dept Surg, Div Urol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM Raffaella.Derosa.mil@mail.mil NR 5 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-4295 EI 1527-9995 J9 UROLOGY JI Urology PD NOV PY 2014 VL 84 IS 5 BP 1211 EP 1213 DI 10.1016/j.urology.2014.07.017 PG 3 WC Urology & Nephrology SC Urology & Nephrology GA AS8CU UT WOS:000344478700065 PM 25239257 ER PT J AU Seehusen, DA Earwood, JS AF Seehusen, Dean A. Earwood, J. Scott TI Oral Contraceptives Are Not an Effective Treatment for Ovarian Cysts SO AMERICAN FAMILY PHYSICIAN LA English DT Editorial Material C1 [Seehusen, Dean A.; Earwood, J. Scott] Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA. RP Seehusen, DA (reprint author), Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA. NR 3 TC 0 Z9 0 U1 1 U2 2 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X EI 1532-0650 J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD NOV 1 PY 2014 VL 90 IS 9 BP 623 EP 623 PG 1 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA AS4BO UT WOS:000344218700005 PM 25368921 ER PT J AU Rettinger, CL Fourcaudot, AB Hong, SJ Mustoe, TA Hale, RG Leung, KP AF Rettinger, Christina L. Fourcaudot, Andrea B. Hong, Seok J. Mustoe, Thomas A. Hale, Robert G. Leung, Kai P. TI In vitro characterization of scaffold-free three-dimensional mesenchymal stem cell aggregates SO CELL AND TISSUE RESEARCH LA English DT Article DE Mesenchymal stem cells; Adipose-derived stem cells; Cell aggregates/spheroids; Three-dimensional culture; Wound healing; Scarring; Rabbit ID MARROW STROMAL CELLS; HUMAN ADIPOSE-TISSUE; BONE-MARROW; GROWTH-FACTOR; HEPATOCYTE SPHEROIDS; PROGENITOR CELLS; ANIMAL-MODELS; MASS-TRANSFER; DIFFERENTIATION; CULTURE AB Mesenchymal stem cells (MSCs) are capable of self-renewal and differentiation along multiple cell lineages and have potential applications in a wide range of therapies. These cells are commonly cultured as monolayers on tissue culture plastic but possibly lose their cell-specific properties with time in vitro. There is growing interest in culturing adherent cells via three-dimensional (3D) techniques in order to recapitulate 3D in vivo conditions. We describe a novel method for generating and culturing rabbit MSCs as scaffold-free 3D cell aggregates by using micropatterned wells via a forced aggregation technique. The viability and proliferative capability of MSC aggregates were assessed via Live/Dead staining and 5-ethynyl-2'-deoxyuridine (EdU) incorporation. Enzyme-linked immunosorbent assay and antibody-based multiplex protein assays were used to quantify released growth factors and chemokines. The gene expression profile of MSCs as 3D aggregates relative to MSCs grown as monolayers was evaluated via quantitative real-time polymerase chain reaction. The rabbit MSCs were able to form compact cell aggregates and remained viable in 3D culture for up to 7 days. We also demonstrated enhanced gene and protein expression related to angiogenesis and wound healing in MSCs cultured under 3D conditions. In vitro tube formation and scratch assay revealed superior neovessel formation and greater cell recovery and migration in response to 3D conditioned media after wounding. Our data further suggest that adipose-derived stem cell aggregates have greater potential than dermal fibroblasts or bone-marrow-derived MSCs in accelerating wound healing and reducing scarring. C1 [Rettinger, Christina L.; Fourcaudot, Andrea B.; Hale, Robert G.; Leung, Kai P.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Hong, Seok J.; Mustoe, Thomas A.] Northwestern Univ, Feinberg Sch Med, Div Plast Surg, Chicago, IL 60611 USA. RP Leung, KP (reprint author), US Army, Inst Surg Res, 3650 Chambers Pass,Bldg 3610, Ft Sam Houston, TX 78234 USA. EM kai.p.leung.civ@mail.mil FU United States Army Medical Research and Material Command [W81XWH-10-2-0054] FX This work was supported by the United States Army Medical Research and Material Command (W81XWH-10-2-0054). The authors are employees of the U.S. Government, and this work was prepared as part of their official duties. NR 48 TC 6 Z9 6 U1 5 U2 38 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0302-766X EI 1432-0878 J9 CELL TISSUE RES JI Cell Tissue Res. PD NOV PY 2014 VL 358 IS 2 BP 395 EP 405 DI 10.1007/s00441-014-1939-0 PG 11 WC Cell Biology SC Cell Biology GA AS6AY UT WOS:000344348500010 PM 25012521 ER PT J AU Hughes, JM Smith, MA Henning, PC Scofield, DE Spiering, BA Staab, JS Hydren, JR Nindl, BC Matheny, RW AF Hughes, Julie M. Smith, Martha A. Henning, Paul C. Scofield, Dennis E. Spiering, Barry A. Staab, Jeffery S. Hydren, Jay R. Nindl, Bradley C. Matheny, Ronald W., Jr. TI Bone formation is suppressed with multi-stressor military training SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE Military training; Bone formation; Bone resorption; Bone metabolism; Bone turnover markers; US Army Ranger School; Recovery ID ENERGY-BALANCE; MARKERS; MEN; INJURIES; PROGRAM; EPIDEMIOLOGY; RESPONSES; TURNOVER; CORTISOL; DENSITY AB To determine the effects of US Army Ranger Training, an 8-week, physically demanding program (energy expenditure of 2,500-4,500 kcal/day) with energy restriction (deficit of 1,000-4,000 kcal/day) and sleep deprivation (< 4 h sleep/night) on bone metabolism. Blood was collected from 22 men (age 24 +/- A 4 years) before and after training. Follow-up measurements were made in a subset of 8 subjects between 2 and 6 weeks after training. Serum was analyzed for bone formation biomarkers [bone alkaline phosphatase (BAP) and osteocalcin (OCN)], bone resorption biomarkers [C-telopeptide cross-links of type I collagen (CTX) and tartrate-resistant acid phosphatase (TRAP5b)], calcium, parathyroid hormone (PTH), and vitamin D (25(OH)D). Data were analyzed using a paired t test to compare baseline to immediate post-training measures. A repeated-measures ANOVA with time as the only factor was used to analyze data on the subset of 8 subjects who completed follow-up data collection. BAP and OCN significantly decreased by 22.8 +/- A 15.5 % (pre 41.9 +/- A 10.1; post 31.7 +/- A 7.8 ng/ml) and 21.0 +/- A 23.3 % (pre 15.0 +/- A 3.5; post 11.3 +/- A 2.1 ng/ml), respectively, with training, suggesting suppressed bone formation. OCN returned to baseline, while BAP remained suppressed 2-6 weeks post-training. TRAP5b significantly increased by 57.5 +/- A 51.6 % (pre 3.0 +/- A 0.9; post 4.6 +/- A 1.4 ng/ml) from pre- to post-training, suggesting increased bone resorption, and returned to baseline 2-6 weeks post-training. PTH Increased significantly by 37.3 +/- A 45.2 % with training. No changes in CTX, calcium, or PTH were detected. These data indicate that multi-stressor military training results in increased bone resorption and suppressed bone formation, with recovery of bone metabolism 2-6 weeks after completion of training. C1 [Hughes, Julie M.; Henning, Paul C.; Scofield, Dennis E.; Spiering, Barry A.; Staab, Jeffery S.; Hydren, Jay R.; Matheny, Ronald W., Jr.] US Army, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA. [Smith, Martha A.] Madigan Healthcare Syst, Joint Base Lewis McChord, Tacoma, WA USA. [Nindl, Bradley C.] Army Publ Hlth Command, Army Inst Publ Hlth, Aberdeen Proving Ground, MD USA. RP Hughes, JM (reprint author), US Army, Mil Performance Div, Environm Med Res Inst, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM julie.m.hughes17.ctr@mail.mil RI SCOFIELD, DENNIS/F-3636-2015; Hydren, Jay/H-3654-2016 OI Hydren, Jay/0000-0001-9385-8898 FU US Army Research Institute of Environmental Medicine; US Department of Energy; US Army Medical Research and Material Command FX This work was supported by appointments to the Postgraduate Research Participation Program at the US Army Research Institute of Environmental Medicine administered by the Oak Ridge Institute for Science and Education through interagency agreement between the US Department of Energy and US Army Medical Research and Material Command (JMH and JRH). NR 40 TC 2 Z9 2 U1 2 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1439-6319 EI 1439-6327 J9 EUR J APPL PHYSIOL JI Eur. J. Appl. Physiol. PD NOV PY 2014 VL 114 IS 11 BP 2251 EP 2259 DI 10.1007/s00421-014-2950-6 PG 9 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA AR9SD UT WOS:000343915300003 PM 25027064 ER PT J AU Hughes, JM Smith, MA Henning, PC Scofield, DE Spiering, BA Staab, JS Hydren, JR Nindl, BC Matheny, RW AF Hughes, Julie M. Smith, Martha A. Henning, Paul C. Scofield, Dennis E. Spiering, Barry A. Staab, Jeffery S. Hydren, Jay R. Nindl, Bradley C. Matheny, Ronald W., Jr. TI Bone formation is suppressed with multi-stressor military training (vol 114, pg 2251, 2014) SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY LA English DT Correction C1 [Hughes, Julie M.; Henning, Paul C.; Scofield, Dennis E.; Spiering, Barry A.; Staab, Jeffery S.; Hydren, Jay R.; Matheny, Ronald W., Jr.] US Army, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA. [Smith, Martha A.] Joint Base Lewis McChord, Madigan Healthcare Syst, Tacoma, WA USA. [Nindl, Bradley C.] Army Publ Hlth Command, Army Inst Publ Hlth, Aberdeen Proving Ground, MD USA. RP Hughes, JM (reprint author), US Army, Mil Performance Div, Environm Med Res Inst, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM julie.m.hughes17.ctr@mail.mil RI SCOFIELD, DENNIS/F-3636-2015; Hydren, Jay/H-3654-2016 OI Hydren, Jay/0000-0001-9385-8898 NR 1 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1439-6319 EI 1439-6327 J9 EUR J APPL PHYSIOL JI Eur. J. Appl. Physiol. PD NOV PY 2014 VL 114 IS 11 BP 2261 EP 2261 DI 10.1007/s00421-014-2972-0 PG 1 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA AR9SD UT WOS:000343915300004 ER PT J AU Brauer, EJ Duncan, DL AF Brauer, Edward J. Duncan, Donald L., Jr. TI Discussion of "Theoretical Analysis of Wing Dike Impact on River Flood Stages" by Fredrik Huthoff, Nicholas Pinter, and Jonathan W. F. Remo SO JOURNAL OF HYDRAULIC ENGINEERING LA English DT Editorial Material C1 [Brauer, Edward J.] US Army Corps Engineers, Appl River Engn Ctr, St Louis, MO 63118 USA. [Duncan, Donald L., Jr.] US Army Corps Engineers, St Louis, MO 63103 USA. RP Brauer, EJ (reprint author), US Army Corps Engineers, Appl River Engn Ctr, Foot Arsenal St, St Louis, MO 63118 USA. EM edward.j.brauer@usace.army.mil NR 7 TC 0 Z9 0 U1 0 U2 2 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9429 EI 1943-7900 J9 J HYDRAUL ENG JI J. Hydraul. Eng.-ASCE PD NOV PY 2014 VL 140 IS 11 AR 07014014 DI 10.1061/(ASCE)HY.1943-7900.0000698 PG 2 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA AS0ZQ UT WOS:000344005700001 ER PT J AU Andersen, RC Wilson, KW Bojescul, JA Mickel, TJ Gordon, WT Potter, BK AF Andersen, Romney C. Wilson, Kevin W. Bojescul, John A. Mickel, Timothy J. Gordon, Wade T. Potter, Benjamin K. TI Open, Combat-Related Loss, or Disruption of the Knee Extensor Mechanism: Treatment Strategies, Classification, and Outcomes SO JOURNAL OF ORTHOPAEDIC TRAUMA LA English DT Article DE extensor mechanism; knee; trauma; open; combat-related; war injuries ID OPERATION ENDURING FREEDOM; PATELLAR TENDON-RUPTURE; FOLLOW-UP; HETEROTOPIC OSSIFICATION; PROXIMAL TIBIA; OPEN FRACTURES; PRIMARY REPAIR; IRAQI FREEDOM; FLAP TRANSFER; VIETNAM-WAR AB Objective: To report the outcomes of repair or reconstruction of high-energy, open knee extensor disruption or loss due to combat-related injuries. Design: Retrospective review. Setting: Tertiary (Level/Role V) Military Treatment Facility. Patients: Fourteen consecutive patients who sustained 17 complex, open knee extensor mechanism injuries during combat operations between March 2003 and May 2012. Intervention: Primary repair or staged allograft extensor reconstruction after serial debridement and closure or soft tissue coverage. Main Outcome Measures: Final knee range of motion, extensor lag, ambulatory ability and assist devices, and complications requiring reoperation or salvage procedure. Results: The open knee extensor mechanism injuries required a mean of 11 procedures per injury. At a mean final follow-up of 39 months (range, 12-89 months), all patients achieved regular community ambulation, with 36% requiring assist devices due to con-comitant or bilateral injuries. Average knee flexion was 92 degrees, and 35% of extremities had an extensor lag >10 degrees; however, 6 of 9 extremities with allograft reconstructions had extensor lags of,10 degrees, and 5 had no extensor lag. The presence of a major periarticular or patellar fracture was significantly associated with the knee requiring a subsequent extensor mechanism allograft reconstruction procedure. One extremity each underwent knee arthrodesis or transfemoral amputation due to severe infection. Conclusions: High-energy, open knee extensor mechanism injuries are severe and rarely occur in isolation, but limb salvage is generally successful after multiple procedures. Patients who required staged allograft reconstruction, despite high complication rates, generally had favorable results. C1 [Andersen, Romney C.; Bojescul, John A.; Gordon, Wade T.; Potter, Benjamin K.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. [Andersen, Romney C.; Wilson, Kevin W.; Mickel, Timothy J.; Gordon, Wade T.; Potter, Benjamin K.] Walter Reed Natl Mil Med Ctr, Dept Orthopaed, Bethesda, MD 20889 USA. [Bojescul, John A.] Dwight D Eisenhower Army Med Ctr, Dept Surg, Orthopaed Surg Serv, Ft Gordon, GA USA. RP Potter, BK (reprint author), Walter Reed Natl Mil Med Ctr, Dept Orthopaed, 8901 Wisconsin Ave,Amer Bldg 19,2nd Floor Ortho, Bethesda, MD 20889 USA. EM benjamin.k.potter.mil@health.mil NR 51 TC 2 Z9 2 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0890-5339 EI 1531-2291 J9 J ORTHOP TRAUMA JI J. Orthop. Trauma PD NOV PY 2014 VL 28 IS 11 BP E250 EP E257 PG 8 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA AS3EL UT WOS:000344159200001 PM 24694556 ER PT J AU Pavey, AR Gorman, GH Kuehn, D Stokes, TA Hisle-Gorman, E AF Pavey, Ashleigh R. Gorman, Gregory H. Kuehn, Devon Stokes, Theophil A. Hisle-Gorman, Elizabeth TI Intimate Partner Violence Increases Adverse Outcomes at Birth and in Early Infancy SO JOURNAL OF PEDIATRICS LA English DT Article ID HEALTH-CARE USE; DOMESTIC VIOLENCE; LATE-PRETERM; RISK-FACTORS; PREGNANCY; ABUSE; WEIGHT; WOMEN; ASSOCIATION; PREVALENCE AB Objective To determine the effect of intimate partner violence (IPV) on birth outcomes and infant hospitalization. Study design Hospitalization records for the first 4 months of life for infants born in the Military Health System in 2006-2007 were linked to Family Advocacy Program-substantiated cases of IPV among military parents. Adverse outcomes were identified using International Classification of Diseases, Ninth Revision codes. Logistic regression modeling calculated the OR of children exposed to IPV experiencing adverse outcomes. Results A total of 204 546 infants were born during the study period. Among these, 173 026 infants (85%) were linked to active duty military parents. 31 603 infants (18%) experienced adverse outcomes, and 3059 infants (1.8%) were born into families with IPV. The infants exposed to IPV had a 31% increased odds of experiencing adverse outcomes compared with infants without known IPV exposure. IPV exposure increased the odds of the following outcomes: prematurity (OR, 1.45; 95% CI, 1.29-1.62), low birth weight (OR, 1.57; 95% CI, 1.25-1.97), respiratory problems (OR, 1.17; 95% CI, 1.04-1.32), neonatal hospitalization (OR, 1.39; 95% CI, 1.20-1.61), and post-neonatal hospitalization (OR, 1.52; 95% CI, 1.29-1.81). After controlling for prematurity and demographic variables, IPV exposure was associated with low birth weight (OR, 1.52; 95% CI, 1.16-1.99), neonatal hospitalization (OR, 1.24; 95% CI, 1.02-1.49), and postneonatal hospitalization (OR, 1.27; 95% CI, 1.03-1.56). Conclusion Infants exposed to IPV are more likely to experience adverse birth outcomes and infant hospitalization. Routinely addressing IPV during prenatal and early pediatric visits may potentially prevent these adverse outcomes. C1 [Pavey, Ashleigh R.; Gorman, Gregory H.; Stokes, Theophil A.] Walter Reed Natl Mil Med Ctr, Dept Pediat, Bethesda, MD 20889 USA. [Gorman, Gregory H.; Kuehn, Devon; Stokes, Theophil A.; Hisle-Gorman, Elizabeth] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. [Kuehn, Devon] Womack Army Med Ctr, Dept Pediat, Ft Bragg, NC USA. RP Pavey, AR (reprint author), Walter Reed Natl Mil Med Ctr, Dept Pediat, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM ashleigh.borges@gmail.com NR 39 TC 4 Z9 4 U1 1 U2 14 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 EI 1097-6833 J9 J PEDIATR-US JI J. Pediatr. PD NOV PY 2014 VL 165 IS 5 BP 1034 EP 1039 DI 10.1016/j.jpeds.2014.06.060 PG 6 WC Pediatrics SC Pediatrics GA AS4HP UT WOS:000344235000034 PM 25128162 ER PT J AU Liming, B Funnell, I Jones, A Demons, S Marshall, K Harsha, W AF Liming, Bryan Funnell, Ian Jones, Anthony Demons, Samandra Marshall, Kathryn Harsha, Wayne TI An Evaluation of Varying Protocols for High-Level Disinfection of Flexible Fiberoptic Laryngoscopes SO LARYNGOSCOPE LA English DT Article DE Flexible fiberoptic laryngoscope; high-level disinfection ID ANAPHYLAXIS FOLLOWING CYSTOSCOPY; ORTHO-PHTHALALDEHYDE; DECONTAMINATION AB Objectives/HypothesisThe use of flexible fiberoptic laryngoscopes (FFLs) is ubiquitous in otolaryngology practices. As with any medical device, there exists a small risk for transmission of pathogenic microorganisms between patients, necessitating high-level decontamination between uses. Most of the literature to date has studied channeled scopes such as those used in esophagogastroduodenoscopy and colonoscopy. A recent study of nonchanneled flexible laryngoscopes suggested that current high-level decontamination practices in use at some institutions, including ours, may be overly aggressive. We sought to evaluate and compare the efficacy of varying techniques of high-level disinfection of FFLs. Study DesignFFLs were used in routine clinical encounters and then disinfected with a variety of techniques. The FFLs were then cultured for bacteria and fungi, and the rates of positive cultures were compared between the techniques and the controls. MethodsIn this study, we took FFLs following use in routine clinical practice and disinfected them using one of eight decontamination protocols. We compared the bacterial and fungal culture results to positive and negative controls. ResultsWe demonstrated that each of the eight cleaning protocols was statistically efficacious at removing bacterial contamination. Our results for fungal cultures did not reach statistical significance. ConclusionsUsing in vitro inoculation of FFLs, this study demonstrated that quicker and more cost-effective practices are equally efficacious to more time-consuming and expensive techniques with regard to bacterial contamination of FFLs. Level of EvidenceNA Laryngoscope, 124:2498-2501, 2014 C1 [Liming, Bryan; Funnell, Ian; Marshall, Kathryn; Harsha, Wayne] Madigan Army Med Ctr, Otolaryngol Head & Neck Surg Serv, Tacoma, WA 98431 USA. [Jones, Anthony; Demons, Samandra] US Army, Med Res Inst Infect Dis, Frederick, MD USA. RP Harsha, W (reprint author), Madigan Army Med Ctr, Otolaryngol Head & Neck Surg Serv, Dept Surg, Bldg 9040,Fitzsimmons Dr, Tacoma, WA 98431 USA. EM wayne.j.harsha.mil@mail.mil FU Department of Clinical Investigation, Madigan Army Medical Center, Tacoma, Washington FX This work was funded by the Department of Clinical Investigation, Madigan Army Medical Center, Tacoma, Washington. NR 22 TC 0 Z9 0 U1 0 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0023-852X EI 1531-4995 J9 LARYNGOSCOPE JI Laryngoscope PD NOV PY 2014 VL 124 IS 11 BP 2498 EP 2501 DI 10.1002/lary.24665 PG 4 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA AS6OH UT WOS:000344382100020 PM 24604624 ER PT J AU Frioux, S Wood, JN Fakeye, O Luan, XQ Localio, R Rubin, DM AF Frioux, Sarah Wood, Joanne N. Fakeye, Oludolapo Luan, Xianqun Localio, Russell Rubin, David M. TI Longitudinal Association of County-Level Economic Indicators and Child Maltreatment Incidents SO MATERNAL AND CHILD HEALTH JOURNAL LA English DT Article DE Child safety; Child maltreatment; Child abuse; Unemployment; Foreclosure ID HEAD TRAUMA; ABUSE; POVERTY; RATES; NEIGHBORHOODS; UNEMPLOYMENT; NEGLECT; RISK; MULTILEVEL; VIOLENCE AB To evaluate the association between economic indicators (unemployment and mortgage foreclosure rates) and volume of investigated and substantiated cases of child maltreatment at the county level from 1990 to 2010 in the Commonwealth of Pennsylvania. County-level investigated reports of child maltreatment and proportion of investigated cases substantiated by child protective services in the Commonwealth of Pennsylvania were compared with county-level unemployment rates from 1990 to 2010, and with county-level mortgage foreclosure rates from 2000 to 2010. We employed fixed-effects Poisson regression modeling to estimate the association between volume of investigated and substantiated cases of maltreatment, and current and prior levels of local economic indicators adjusting for temporal trend. Across Pennsylvania, annual rate of investigated maltreatment reports decreased through the 1990s and rose in the early 2000s before reaching a peak of 9.21 investigated reports per 1,000 children in 2008, during the recent economic recessionary period. The proportion of investigated cases substantiated, however, decreased statewide from 33 % in 1991 to 15 % in 2010. Within counties, current unemployment rate, and current and prior-year foreclosure rates were positively associated with volume of both investigated and substantiated child maltreatment incidents (p < 0.05). Despite recent increases in investigations, the proportion of investigated cases substantiated decreased by more than half from 1990 to 2010 in Pennsylvania. This trend suggests significant changes in substantiation standards and practices during the period of study. Economic indicators demonstrated strong association with investigated and substantiated maltreatment, underscoring the urgent need for directing important prophylactic efforts and resources to communities experiencing economic hardship. C1 [Frioux, Sarah] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Wood, Joanne N.; Fakeye, Oludolapo; Luan, Xianqun; Localio, Russell; Rubin, David M.] Childrens Hosp Philadelphia, PolicyLab, Div Gen Pediat, Philadelphia, PA 19104 USA. [Wood, Joanne N.; Rubin, David M.] Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA. [Localio, Russell] Univ Penn, Dept Biostat & Epidemiol, Perelman Sch Med, Philadelphia, PA 19104 USA. RP Wood, JN (reprint author), Childrens Hosp Philadelphia, PolicyLab, Div Gen Pediat, Philadelphia, PA 19104 USA. EM woodjo@email.chop.edu OI Wood, Joanne/0000-0001-6431-8024 FU NICHD NIH HHS [1K23HD071967-01, K23 HD071967] NR 37 TC 5 Z9 5 U1 3 U2 12 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1092-7875 EI 1573-6628 J9 MATERN CHILD HLTH J JI Matern. Child Health J. PD NOV PY 2014 VL 18 IS 9 BP 2202 EP 2208 DI 10.1007/s10995-014-1469-0 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AR9XE UT WOS:000343929300021 PM 24682605 ER PT J AU White, JF Torres, MS Sullivan, RF Jabbour, RE Chen, Q Tadych, M Irizarry, I Bergen, MS Havkin-Frenkel, D Belanger, FC AF White, James F., Jr. Torres, Monica S. Sullivan, Raymond F. Jabbour, Rabih E. Chen, Qiang Tadych, Mariusz Irizarry, Ivelisse Bergen, Marshall S. Havkin-Frenkel, Daphna Belanger, Faith C. TI Occurrence of Bacillus amyloliquefaciens as a Systemic Endophyte of Vanilla Orchids SO MICROSCOPY RESEARCH AND TECHNIQUE LA English DT Article DE lipopeptides; plant disease protection; defensive mutualism; endospores ID DEFENSIVE MUTUALISM; FUNGAL ENDOPHYTES; BIOCONTROL; DISEASE; PLANTS; LIPOPEPTIDES; SYMBIOSIS; PSEUDOMONAS; DIVERSITY; SURFACTIN AB We report the occurrence of Bacillus amyloliquefaciens in vanilla orchids (Vanilla phaeantha) and cultivated hybrid vanilla (V. planifolia x V. pompona) as a systemic bacterial endophyte. We determined with light microscopy and isolations that tissues of V. phaeantha and the cultivated hybrid were infected by a bacterial endophyte and that shoot meristems and stomatal areas of stems and leaves were densely colonized. We identified the endophyte as B. amyloliquefaciens using DNA sequence data. Since additional endophyte-free plants and seed of this orchid were not available, additional studies were performed on surrogate hosts Amaranthus caudatus, Ipomoea tricolor, and I. purpurea. Plants of A. caudatus inoculated with B. amyloliquefaciens demonstrated intracellular colonization of guard cells and other epidermal cells, confirming the pattern observed in the orchids. Isolations and histological studies suggest that the bacterium may penetrate deeply into developing plant tissues in shoot meristems, forming endospores in maturing tissues. B. amyloliquefaciens produced fungal inhibitors in culture. In controlled experiments using morning glory seedlings we showed that the bacterium promoted seedling growth and reduced seedling necrosis due to pathogens. We detected the gene for phosphopantetheinyl transferase (sfp), an enzyme in the pathway for production of antifungal lipopeptides, and purified the lipopeptide surfactin from cultures of the bacterium. We hypothesize that B. amyloliquefaciens is a robust endophyte and defensive mutualist of vanilla orchids. Whether the symbiosis between this bacterium and its hosts can be managed to protect vanilla crops from diseases is a question that should be evaluated in future research. Microsc. Res. Tech. 77:874-885, 2014. (c) 2014 Wiley Periodicals, Inc. C1 [White, James F., Jr.; Torres, Monica S.; Chen, Qiang; Tadych, Mariusz; Irizarry, Ivelisse; Bergen, Marshall S.; Havkin-Frenkel, Daphna; Belanger, Faith C.] Rutgers State Univ, Dept Plant Biol & Pathol, New Brunswick, NJ 08901 USA. [Sullivan, Raymond F.] US Army CBRNE Analyt & Remediat Act, Aberdeen Proving Ground, MD USA. [Jabbour, Rabih E.] US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. RP White, JF (reprint author), Rutgers State Univ, Dept Plant Biol & Pathol, 59 Dudley Rd, New Brunswick, NJ 08901 USA. EM white@rci.rutgers.edu RI Tadych, Mariusz/G-4449-2015 OI Tadych, Mariusz/0000-0003-4776-1096 FU USDA NIFA Multi-State Project 3147; John E. and Christina C. Craighead Foundation; New Jersey Agricultural Experiment Station FX Contract grant sponsor: USDA NIFA Multi-State Project 3147, the John E. and Christina C. Craighead Foundation, and the New Jersey Agricultural Experiment Station. NR 33 TC 8 Z9 9 U1 1 U2 24 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1059-910X EI 1097-0029 J9 MICROSC RES TECHNIQ JI Microsc. Res. Tech. PD NOV PY 2014 VL 77 IS 11 BP 874 EP 885 DI 10.1002/jemt.22410 PG 12 WC Anatomy & Morphology; Biology; Microscopy SC Anatomy & Morphology; Life Sciences & Biomedicine - Other Topics; Microscopy GA AS5XC UT WOS:000344338900004 PM 25060609 ER PT J AU Hu, LZ Busby, RR Gebhart, DL Yannarell, AC AF Hu, Lingzi Busby, Ryan R. Gebhart, Dick L. Yannarell, Anthony C. TI Invasive Lespedeza cuneata and native Lespedeza virginica experience asymmetrical benefits from rhizobial symbionts SO PLANT AND SOIL LA English DT Article DE Lespedeza cuneata (Dum. Cours.) G. Don; Lespedeza virginica (L.) Britton; Invasive plants; Bradyrhizobium; Symbiosis; Competition ID ARBUSCULAR MYCORRHIZAL FUNGI; NITROGEN-FIXATION; GENETIC DIVERSITY; ACACIA-LONGIFOLIA; PLANT INVASIONS; SOIL BIOTA; LEGUME; COMMUNITIES; MUTUALISMS; BACTERIA AB Lespedeza cuneata (Dum. Cours.) G. Don is an invasive legume that displaces populations of native N. American congeners. Our aims are to determine the growth benefits of different rhizobacterial strains for L. cuneata and native Lespedeza virginica (L.) Britton, and to determine if these strains influence competition between these plants. Plants were grown under nitrogen-limiting conditions in sterilized soil in pairs consisting of two L. cuneata, two L. virginica, or one of each species, and then plants were inoculated with one of seven rhizobial isolates, or with a no-strain control. After 3 months, plants were harvested for determination of biomass and nodulation rate. Five of the assayed stains improved L. cuneata biomass over uninoculated controls, but none of the strains benefited L. virginica. L. cuneata plants had more biomass and root nodules when grown in competition with L. virginica than with a conspecific. Asymmetrical benefits from these symbionts accrued to invasive L. cuneata but not to native L. virginica, and this may provide the invader with a growth advantage in the field. Changes in the availability of effective symbionts in the soils of invaded sites can shape performance of native and invasive plants. C1 [Hu, Lingzi; Yannarell, Anthony C.] Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA. [Busby, Ryan R.; Gebhart, Dick L.] US Army Engn Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL USA. RP Yannarell, AC (reprint author), Univ Illinois, Dept Nat Resources & Environm Sci, 1102 S Goodwin Ave, Urbana, IL 61801 USA. EM acyann@illinois.edu FU U.S. Army Engineer Research and Development Center [Army W9132T-09-2-0011]; Cooperative State Research, Education and Extension Service, U.S. Department of Agriculture [ILLU-875-317] FX The authors acknowledge A. Leonard and J. Proffitt for assistance with field work. S. Taylor, J. Dawson, K. Heath, and A. Kent provided valuable assistance during design of this research and the preparation of this manuscript. This work was supported by grant Army W9132T-09-2-0011 from the U.S. Army Engineer Research and Development Center and also by the Cooperative State Research, Education and Extension Service, U.S. Department of Agriculture, under project number ILLU-875-317. NR 58 TC 2 Z9 2 U1 9 U2 49 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0032-079X EI 1573-5036 J9 PLANT SOIL JI Plant Soil PD NOV PY 2014 VL 384 IS 1-2 BP 315 EP 325 DI 10.1007/s11104-014-2213-7 PG 11 WC Agronomy; Plant Sciences; Soil Science SC Agriculture; Plant Sciences GA AS5WA UT WOS:000344336200023 ER PT J AU George, J Compton, JR Leary, DH Olson, MA Legler, PM AF George, Jade Compton, Jaimee R. Leary, Dagmar H. Olson, Mark A. Legler, Patricia M. TI Structural and mutational analysis of a monomeric and dimeric form of a single domain antibody with implications for protein misfolding SO PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS LA English DT Article DE misfolded; metastable states; irreversible unfolding; asymmetric; homodimeric; single domain antibody; amyloid-like; fibril; kinetically stable ID LIGHT-CHAIN AMYLOIDOSIS; BETA-SHEET STRUCTURE; BENCE-JONES PROTEIN; LLAMA VHH DOMAIN; KINETIC STABILITY; CRYSTAL-STRUCTURE; THEORETICAL-ANALYSIS; VARIABLE DOMAINS; DISULFIDE BONDS; TRANSTHYRETIN AB Camelid single domain antibodies (sdAb) are known for their thermal stability and reversible refolding. We have characterized an unusually stable sdAb recognizing Staphylococcal enterotoxin B with one of the highest reported melting temperatures (T-m=85 degrees C). Unexpectedly, approximate to 10-20% of the protein formed a dimer in solution. Three other cases where <20% of the sdAb dimerized have been reported; however, this is the first report of both the monomeric and dimeric X-ray crystal structures. Concentration of the monomer did not lead to the formation of new dimer suggesting a stable conformationally distinct species in a fraction of the cytoplasmically expressed protein. Comparison of periplasmic and cytoplasmic expression showed that the dimer was associated with cytoplasmic expression. The disulfide bond was partially reduced in the WT protein purified from the cytoplasm and the protein irreversibly unfolded. Periplasmic expression produced monomeric protein with a fully formed disulfide bond and mostly reversible refolding. Crystallization of a disulfide-bond free variant, C22A/C99V, purified from the periplasm yielded a structure of a monomeric form, while crystallization of C22A/C99V from the cytoplasm produced an asymmetric dimer. In the dimer, a significant conformational asymmetry was found in the loop residues of the edge -strands (S50-Y60) containing the highly variable complementarity determining region, CDR2. Two dimeric assemblies were predicted from the crystal packing. Mutation of a residue at one of the interfaces, Y98A, disrupted the dimer in solution. The pleomorphic homodimer may yield insight into the stability of misfolded states and the importance of the conserved disulfide bond in preventing their formation. Proteins 2014; 82:3101-3116. (c) 2014 Wiley Periodicals, Inc. C1 [George, Jade] Bowie State Univ, Bowie, MD 20715 USA. [Compton, Jaimee R.] NOVA Res Inc, Alexandria, VA 22308 USA. [Leary, Dagmar H.; Legler, Patricia M.] US Army, Med Res Inst Infect Dis, Dept Cell Biol & Biochem, Frederick, MD 21702 USA. [Olson, Mark A.] Naval Res Labs, Washington, DC USA. RP Legler, PM (reprint author), Naval Res Labs, 4555 Overlook Ave, Washington, DC USA. EM patricia.legler@nrl.navy.mil FU DTRA [CBCALL12-LS6-2-0036]; NRL HBCU/MI summer internship program - Office of Naval Research (ONR) [N0001412RX20102]; ONR/NRL 6.1 base funding FX Grant sponsor: DTRA; Grant number: CBCALL12-LS6-2-0036; Grant sponsor: NRL HBCU/MI summer internship program sponsored by the Office of Naval Research (ONR); Grant number: N0001412RX20102; Grant sponsor: ONR/NRL 6.1 base funding. NR 65 TC 6 Z9 6 U1 4 U2 49 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0887-3585 EI 1097-0134 J9 PROTEINS JI Proteins PD NOV PY 2014 VL 82 IS 11 BP 3101 EP 3116 DI 10.1002/prot.24671 PG 16 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA AS6MT UT WOS:000344378300020 PM 25136772 ER PT J AU Schatzman, D Wilson, J Arad, E Seifert, A Shtendel, T AF Schatzman, David Wilson, Jacob Arad, Eran Seifert, Avraham Shtendel, Tom TI Drag-Reduction Mechanisms of Suction-and-Oscillatory-Blowing Flow Control SO AIAA JOURNAL LA English DT Article ID HIGH REYNOLDS-NUMBERS; SEPARATION CONTROL; PART 1 AB An active-flow-control study, using steady suction-and-oscillatory-blowing actuators, was conducted on an axisymmetric bluff-body model for a range of Reynolds numbers between 2 x 10(6) and 5 x 10(6). Previous work on the same model demonstrated the experimental implementation and efficient drag reduction of the suction-and-oscillatory-blowing actuator system, including comparisons to computational fluid dynamics results. The current study presents a detailed analysis of the experimental data, coupled with a refined computational model toward a flow-physics understanding of the drag-reduction mechanisms of the suction-and-oscillatory-blowing active-flow-control system. The boundary-layer response was examined using time-averaged and phase-averaged hot-wire measurements conducted on the aft portion of the model where active flow control was applied. The drag-reduction behavior was scaled using multiple active-flow-control parameters associated with the unique and complex features of the suction-and-oscillatory-blowing active-flow-control system. The results show that the drag-reduction mechanisms associated with the suction-and-oscillatory-blowing actuation system include boundary-layer suction, wall-jet momentum addition, unsteady shear-layer excitation, the generation of thrust, and streamwise vortices. C1 [Schatzman, David] Sci & Technol Corp, Moffett Field, CA 94035 USA. [Wilson, Jacob] US Army Res Dev & Engn Command, Moffett Field, CA 94035 USA. [Arad, Eran] RAFAEL Adv Def Syst Ltd, CFD, IL-31021 Haifa, Israel. [Seifert, Avraham; Shtendel, Tom] Tel Aviv Univ, Fac Engn, Sch Mech Engn, IL-69978 Tel Aviv, Israel. RP Schatzman, D (reprint author), NASA, Ames Res Ctr, US Army Aviat Dev Directorate, Aeroflightdynam Directorate, Washington, DC 20024 USA. NR 23 TC 2 Z9 2 U1 2 U2 16 PU AMER INST AERONAUTICS ASTRONAUTICS PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0001-1452 EI 1533-385X J9 AIAA J JI AIAA J. PD NOV PY 2014 VL 52 IS 11 BP 2491 EP 2505 DI 10.2514/1.J052903 PG 15 WC Engineering, Aerospace SC Engineering GA AR8AX UT WOS:000343799000011 ER PT J AU Campbell, K McNamee, SE Huet, AC Delahaut, P Vilarino, N Botana, LM Poli, M Elliott, CT AF Campbell, Katrina McNamee, Sara E. Huet, Anne-Catherine Delahaut, Philippe Vilarino, Natalia Botana, Luis M. Poli, Mark Elliott, Christopher T. TI Evolving to the optoelectronic mouse for phycotoxin analysis in shellfish SO ANALYTICAL AND BIOANALYTICAL CHEMISTRY LA English DT Article DE Multiplex; Phycotoxins; Optical biosensor; Shellfish; Antibody; Validation ID OPTICAL BIOSENSOR TECHNOLOGY; SINGLE-LABORATORY VALIDATION; PLASMON RESONANCE BIOSENSOR; MARINE TOXINS; DOMOIC ACID; LIQUID-CHROMATOGRAPHY; POISONING TOXINS; PERFORMANCE; BIOTOXINS; TOXICITY AB Despite ethical and technical concerns, the in vivo method, or more commonly referred to mouse bioassay (MBA), is employed globally as a reference method for phycotoxin analysis in shellfish. This is particularly the case for paralytic shellfish poisoning (PSP) and emerging toxin monitoring. A high-performance liquid chromatography method (HPLC-FLD) has been developed for PSP toxin analysis, but due to difficulties and limitations in the method, this procedure has not been fully implemented as a replacement. Detection of the diarrhetic shellfish poisoning (DSP) toxins has moved towards LC-mass spectrometry (MS) analysis, whereas the analysis of the amnesic shellfish poisoning (ASP) toxin domoic acid is performed by HPLC. Although alternative methods of detection to the MBA have been described, each procedure is specific for a particular toxin and its analogues, with each group of toxins requiring separate analysis utilising different extraction procedures and analytical equipment. In addition, consideration towards the detection of unregulated and emerging toxins on the replacement of the MBA must be given. The ideal scenario for the monitoring of phycotoxins in shellfish and seafood would be to evolve to multiple toxin detection on a single bioanalytical sensing platform, i.e. 'an artificial mouse'. Immunologically based techniques and in particular surface plasmon resonance technology have been shown as a highly promising bioanalytical tool offering rapid, real-time detection requiring minimal quantities of toxin standards. A Biacore Q and a prototype multiplex SPR biosensor have been evaluated for their ability to be fit for purpose for the simultaneous detection of key regulated phycotoxin groups and the emerging toxin palytoxin. Deemed more applicable due to the separate flow channels, the prototype performance for domoic acid, okadaic acid, saxitoxin, and palytoxin calibration curves in shellfish achieved detection limits (IC20) of 4,000, 36, 144 and 46 mu g/kg of mussel, respectively. A one-step extraction procedure demonstrated recoveries greater than 80 % for all toxins. For validation of the method at the 95 % confidence limit, the decision limits (CC alpha) determined from an extracted matrix curve were calculated to be 450, 36 and 24 mu g/kg, and the detection capability (CC beta) as a screening method is a parts per thousand currency sign10 mg/kg, a parts per thousand currency sign160 mu g/kg and a parts per thousand currency sign400 mu g/kg for domoic acid, okadaic acid and saxitoxin, respectively. C1 [Campbell, Katrina; McNamee, Sara E.; Elliott, Christopher T.] Queens Univ, IGFS, Sch Biol Sci, Belfast BT9 5AG, Antrim, North Ireland. [Huet, Anne-Catherine; Delahaut, Philippe] CER Grp, B-6900 Marloie, Belgium. [Vilarino, Natalia; Botana, Luis M.] Univ Santiago Compostela, Dept Farmacol, Fac Vet, Lugo 27002, Spain. [Poli, Mark] US Army Med Res Inst Infect Dis, Integrated Toxicol Div, Frederick, MD 21702 USA. RP Campbell, K (reprint author), Queens Univ, IGFS, Sch Biol Sci, David Keir Bldg,Stranmillis Rd, Belfast BT9 5AG, Antrim, North Ireland. EM katrina.campbell@qub.ac.uk OI Vilarino, Natalia/0000-0001-6055-6359 FU CONffIDENCE: EU FP7 project "CONtaminants in Food and Feed: Inexpensive Detection for Control of Exposure"; European Commission [211326]; Advanced ASSET project at Queen's University Belfast - InvestNI; European Regional Development Fund ("ERDF") FX This research was funded through CONffIDENCE: EU FP7 project "CONtaminants in Food and Feed: Inexpensive Detection for Control of Exposure" supported by the European Commission (grant agreement number 211326-collaborative project) and the Advanced ASSET project at Queen's University Belfast funded through InvestNI and from the European Sustainable Programme 2007-2013 under the European Regional Development Fund ("ERDF"). The authors would like to thank the National Reference Laboratories for Marine biotoxins who contributed samples to the study. NR 37 TC 4 Z9 5 U1 1 U2 39 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1618-2642 EI 1618-2650 J9 ANAL BIOANAL CHEM JI Anal. Bioanal. Chem. PD NOV PY 2014 VL 406 IS 27 BP 6867 EP 6881 DI 10.1007/s00216-014-8156-2 PG 15 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA AR8DG UT WOS:000343805100012 PM 25245418 ER PT J AU Kwon, HP Zanders, TB Regn, DD Burkett, SE Ward, JA Nguyen, R Necsoiu, C Jordan, BS York, GE Jimenez, S Chung, KK Cancio, LC Morris, MJ Batchinsky, AI AF Kwon, Herbert P. Zanders, Thomas B. Regn, Dara D. Burkett, Samuel E. Ward, John A. Nguyen, Ruth Necsoiu, Corina Jordan, Bryan S. York, Gerald E. Jimenez, Santiago Chung, Kevin K. Cancio, Leopoldo C. Morris, Michael J. Batchinsky, Andriy I. TI Comparison of virtual bronchoscopy to fiber-optic bronchoscopy for assessment of inhalation injury severity SO BURNS LA English DT Article DE Inhalation injury; Virtual bronchoscopy; Fiber-optic bronchoscopy; Swine; Computed tomography scan ID RESPIRATORY-DISTRESS-SYNDROME; COMPUTED-TOMOGRAPHY; MANAGEMENT; LUNG; CT; DIAGNOSIS; STENOSIS; LESIONS AB Purpose: Compare virtual bronchoscopy (VB) to fiberoptic bronchoscopy (FOB) for scoring smoke inhalation injury (SII). Methods: Swine underwent computerized tomography (CT) with VB and FOB before (0) and 24 and 48 h after SII. VB and FOB images were scored by 5 providers off line. Results: FOB and VB scores increased over time (p <0.001) with FOB scoring higher than VB at 0 (0.30 +/- 0.79 vs. 0.03 +/- 0.17), 24 h (4.21 +/- 1.68 vs. 2.47 +/- 1.50), and 48 h (4.55 +/- 1.83 vs. 1.94 +/- 1.29). FOB and VB showed association with PaO2-to-FiO(2) ratios (PFR) with areas under receiver operating characteristic curves (ROC): for PFR <= 300, VB 0.830, FOB 0.863; for PFR <= 200, VS 0.794, FOB 0.825; for PFR <= 100, VS 0.747, FOB 0.777 (all p <0.001). FOB showed 80.3% specificity, 77% sensitivity, 88.8% negative-predictive value (NPV), and 62.3% positive-predictive value (PPV) for PFR <= 300 and VB showed 67.2% specificity, 85.5% sensitivity, 91.3% NPV, and 53.4% PPV. Conclusions: VB provided similar injury severity scores to FOB, correlated with PFR, and reliably detected airway narrowing. VS performed during admission CT may be a useful screening tool specifically to demonstrate airway narrowing induced by SII. (C) 2014 Elsevier Ltd and ISBI. All rights reserved. C1 [Kwon, Herbert P.; Zanders, Thomas B.; Regn, Dara D.; Burkett, Samuel E.; Nguyen, Ruth; Necsoiu, Corina; Morris, Michael J.] Brooke Army Med Ctr, Pulm Crit Care Serv, Dept Med, Ft Sam Houston, TX 78234 USA. [Jordan, Bryan S.; Chung, Kevin K.; Cancio, Leopoldo C.; Batchinsky, Andriy I.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA. [York, Gerald E.; Jimenez, Santiago] Brooke Army Med Ctr, Dept Radiol, Jbsa Ft Sam Houston, TX 78234 USA. [Ward, John A.] Brooke Army Med Ctr, Dept Clin Invest, Jbsa Ft Sam Houston, TX 78234 USA. RP Batchinsky, AI (reprint author), US Army Inst Surg Res, Comprehens Intens Care Res Task Area, Battlefield Hlth & Trauma Res Inst, DTRD,DECS,NAMRU SA, BHT2,Bldg 3610,3650 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA. EM andriy.i.batchinsky.vol@mail.mil FU Comprehensive Intensive Care Research Task Area, Combat Casualty Care Research Area Directorate, U.S. Army Medical Research and Materiel Command FX Funded by the Comprehensive Intensive Care Research Task Area, Combat Casualty Care Research Area Directorate, U.S. Army Medical Research and Materiel Command. NR 40 TC 6 Z9 7 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 EI 1879-1409 J9 BURNS JI Burns PD NOV PY 2014 VL 40 IS 7 BP 1308 EP 1315 DI 10.1016/j.burns.2014.06.007 PG 8 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA AR8SB UT WOS:000343843600008 PM 25112807 ER PT J AU Smith, AN Nochetto, H AF Smith, Andrew N. Nochetto, Horacio TI Laminar thermally developing flow in rectangular channels and parallel plates: uniform heat flux SO HEAT AND MASS TRANSFER LA English DT Article ID MICROCHANNELS AB Numerical simulations were conducted for thermally developing laminar flow in rectangular channels with aspect ratios ranging from 1 to 100, and for parallel plates. The simulations were for laminar, thermally developing flow with H1 boundary conditions: uniform heat flux along the length of the channel and constant temperature around the perimeter. In the limit as the non-dimensional length, x* = x/(D (h) RePr), goes to zero, the Nusselt number is dependent on x* to the negative exponent m. As the non-dimensional length goes to infinity the Nusselt number approaches fully developed values that are independent of x*. General correlations for the local and mean heat transfer coefficients are presented that use an asymptotic blending function to transition between these limiting cases. The discrepancy between the correlation and the numerical results is less than 2.5 % for all aspect ratios. The correlations presented are applicable to all aspect ratios and all non-dimensional lengths, and decrease the discrepancy relative to existing correlations. C1 [Smith, Andrew N.] US Naval Acad, Annapolis, MD 21146 USA. [Smith, Andrew N.; Nochetto, Horacio] US Army Res Lab, Adelphi, MD 20783 USA. RP Smith, AN (reprint author), US Naval Acad, 590 Holloway Rd, Annapolis, MD 21146 USA. EM ansmith@usna.edu FU U.S Army Research Laboratory FX The authors would like to thank the U.S Army Research Laboratory for their financial support and the members of the Power Components Branch for their input and discussions. Contributions to this paper by Andrew Smith were made while on sabbatical at the U. S. Army Research Lab, Adelphi, MD. NR 14 TC 3 Z9 3 U1 2 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0947-7411 EI 1432-1181 J9 HEAT MASS TRANSFER JI Heat Mass Transf. PD NOV PY 2014 VL 50 IS 11 BP 1627 EP 1637 DI 10.1007/s00231-014-1363-8 PG 11 WC Thermodynamics; Mechanics SC Thermodynamics; Mechanics GA AR7IW UT WOS:000343753800013 ER PT J AU Remick, KN Wong, EG Chep, CC Morton, RT Monsour, A Fisher, D Oh, JS Wilson, R Malone, DL Branas, C Elster, E Gross, KR Kushner, AL AF Remick, Kyle N. Wong, Evan G. Chep, Chep Chuot Morton, Richard T. Monsour, Abdullah Fisher, Dane Oh, John S. Wilson, Ramey Malone, Debra L. Branas, Charles Elster, Eric Gross, Kirby R. Kushner, Adam L. TI Development of a novel Global Trauma System Evaluation Tool and initial results of implementation in the Republic of South Sudan SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED LA English DT Article DE Trauma systems; Global surgery; Global injury; International surgery; Injury care ID CARE CAPABILITIES; GUIDELINES; MORTALITY; SURGERY AB Introduction: Trauma remains a leading cause of death and disability in the world, and trauma systems decrease mortality from trauma. We developed the Global Trauma System Evaluation Tool (G-TSET) specifically for use in low-and middle-income countries (LMICs). The Sudan People's Liberation Army (SPLA) in the Republic of South Sudan (RSS) desires a military trauma system (MTS) which allowed us to pilot the G-TSET. Methods: The G-TSET was developed by modifying key components of a trauma system applicable to LMICs. We partnered with the SPLA Medical Corps using clinical collaboration, direct observation, and discussion groups. Benchmarks and indicators were scored with 5 indicating "full capability" and 1 meaning "not present" and were used to develop a SPLA MTS plan. Results: The overall MTS score was 1.15 indicating an urgent need for system development. The assessment highlighted the need for SPLA Command support. Battlefield care, transport to a trauma facility, and inter-facility communication were identified for improvement. After essential battlefield care, consisting primarily of bandaging and splinting, transport times for injured SPLA soldiers were 12 h to 3 days by truck. Based on our findings, we collaborated with SPLA medical leadership to develop a plan to develop a formal MTS. Conclusion: We piloted a novel trauma system assessment tool for the MTS in the RSS. Qualitatively, we identified gaps in the MTS and provided the medical leadership with a plan for improvement. We anticipate a short-term follow-up to quantify improvement, and we seek to validate this tool for use in other countries. Published by Elsevier Ltd. C1 [Remick, Kyle N.; Oh, John S.; Malone, Debra L.] Walter Reed Natl Mil Med Ctr, Bethesda, MD 20889 USA. [Remick, Kyle N.; Oh, John S.; Malone, Debra L.; Elster, Eric] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. [Wong, Evan G.; Kushner, Adam L.] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA. [Chep, Chep Chuot; Monsour, Abdullah] SPLA Mil Hosp, SPLA Med Corps, Juba, Sudan. [Morton, Richard T.] 212th Combat Support Hosp, Miesau, Germany. [Fisher, Dane] Uniformed Serv Univ Hlth Sci, Sch Med, Bethesda, MD 20814 USA. [Wilson, Ramey] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. [Branas, Charles] Univ Penn, Perelman Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA. [Gross, Kirby R.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA. [Kushner, Adam L.] Surg OverSeas SOS, New York, NY 10009 USA. [Kushner, Adam L.] Columbia Univ, Dept Surg, New York, NY USA. RP Remick, KN (reprint author), Walter Reed Natl Mil Med Ctr, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM kyleremickmd@yahoo.com; evan.wong@mail.mcgill.ca; chepchuot@yahoo.com; armytraumanurse@yahoo.com; amelnayer2013@gmail.com; dane.fisher@usuhs.edu; john.s.oh.mil@health.mil; ramey.wilson@usuhs.edu; debra.l.malone.mil@health.mil; cbranas@upenn.edu; eric.elster@usuhs.edu; Kirby.r.gross.mil@mail.mil; adamkushner@yahoo.com OI Kushner, Adam/0000-0002-7797-4837 NR 22 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0020-1383 EI 1879-0267 J9 INJURY JI Injury-Int. J. Care Inj. PD NOV PY 2014 VL 45 IS 11 BP 1731 EP 1735 DI 10.1016/j.injury.2014.08.004 PG 5 WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery GA AR9ME UT WOS:000343898000011 PM 25192865 ER PT J AU Proctor, SP Maule, AL Heaton, KJ Adam, GE AF Proctor, Susan P. Maule, Alexis L. Heaton, Kristin J. Adam, Gina E. TI Permethrin exposure from fabric-treated military uniforms under different wear-time scenarios SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY LA English DT Article DE permethrin; urinary biomarkers; absorbed dose; military; biomonitoring; pesticides; epidemiology ID PYRETHROID INSECTICIDES; IXODES-RICINUS; US POPULATION; METABOLITES; IMPREGNATION; HEALTH; TICKS AB The objective of the project was to ascertain whether urinary biomarkers of permethrin exposure are detected after wearing post-tailored, fabric-treated military uniforms under two different wear-time exposure scenarios. Study A occurred over 3.5 days and involved six participants wearing treated uniforms continuously for 30-32 h. Urine collection occurred at scheduled time points before, during, and after wearing the uniform. Study B, conducted over 19 days, included 11 participants wearing treated uniforms for 3 consecutive days, 8 h each day (with urine collection before, during, and after wear). Urinary biomarkers of permethrin (3-phenoxybenzoic acid (3PBA), cis- 2,2-(dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid (cDCCA), trans- 2,2(dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid (tDCCA)) were detected during and after wear. Biomarker detection generally occurred over the 10- to 12-h period after putting on the uniform and subsided 24 h following uniform removal (in both Study A and B scenarios). Those wearing permethrin-treated uniforms under the longer wear-time scenario (Study A) excreted significantly higher cumulative mean levels compared with those in Study B (3.29 times higher for 3PBA and 2.23 times higher for the sum of c/tDCCA (P <= 0.001)). Findings suggest that wearing permethrin-treated clothing does increase absorbed, internal dose levels of permethrin above population levels and is significantly related to wear-time duration. C1 [Proctor, Susan P.; Maule, Alexis L.; Heaton, Kristin J.; Adam, Gina E.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA. [Proctor, Susan P.; Maule, Alexis L.; Heaton, Kristin J.] Boston Univ, Sch Publ Hlth, Boston, MA USA. [Proctor, Susan P.] VA Boston Healthcare Syst, Boston, MA USA. RP Proctor, SP (reprint author), US Army Res Inst Environm Med, Mil Performance Div, Kansas St Bldg 42, Natick, MA 01760 USA. EM susan.p.proctor.civ@mail.mil NR 20 TC 3 Z9 3 U1 0 U2 7 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1559-0631 EI 1559-064X J9 J EXPO SCI ENV EPID JI J. Expo. Sci. Environ. Epidemiol. PD NOV-DEC PY 2014 VL 24 IS 6 BP 572 EP 578 DI 10.1038/jes.2013.65 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA AS0IJ UT WOS:000343960800004 PM 24104061 ER PT J AU Crowell, MS Alitz, C AF Crowell, Michael S. Alitz, Curtis TI Progression of a Lumbar Disc Extrusion SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Editorial Material C1 [Crowell, Michael S.] Army Baylor Univ, West Point, NY 10996 USA. [Alitz, Curtis] Keller Army Community Hosp, West Point, NY USA. RP Crowell, MS (reprint author), Army Baylor Univ, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD NOV PY 2014 VL 44 IS 11 BP 910 EP 910 DI 10.2519/jospt.2014.0413 PG 1 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA AR8XF UT WOS:000343854000008 PM 25361862 ER PT J AU Krueger, CA Aden, JK Broughton, K Rispoli, DM AF Krueger, Chad A. Aden, James K. Broughton, Kimberly Rispoli, Damian M. TI Radioulnar space available at the level of the biceps tuberosity for repaired biceps tendon: a comparison of 4 techniques SO JOURNAL OF SHOULDER AND ELBOW SURGERY LA English DT Article DE Distal biceps repair; distal biceps impingement; distal biceps insertion; distal biceps repair techniques ID BRACHII TENDON; SURGICAL-TREATMENT; SUTURE ANCHORS; DISTAL; ANATOMY; RUPTURE; INSERTION; ENDOBUTTON; RELEVANCE; INCISION AB Hypothesis: It is unknown whether certain methods of distal biceps tendon repair lead to an increased propensity of impingement of the repaired tendon. The purpose of this study was to evaluate various repair techniques in a cadaveric model to determine the radioulnar space available for the repaired biceps tendons. Methods: Nine matched pairs of quartered, fresh-frozen cadaveric arms were transected at the level of the humeral mid shaft and the distal radiocarpal joint. Distance measurements and the angular relation of the bicipital tuberosity were measured at 5 forearm pronation-supination positions. These measurements were taken under each of the following conditions: intact native biceps, resected native tendon, suture anchor fixation of the biceps, suspensory suture device fixation of the biceps, tendon repair using a tenodesis technique, and fixation of the tendon using a trough technique. Results: There were no significant differences in radioulnar space available after biceps tendon repair with the forearm in a supinated position. However, when the forearm was in a neutral or pronated position, the suture anchor method consistently had the lowest biceps insertion-to-ulna distance (0.6 to 2.1 cm). All forearm positions, except full supination, showed significant differences in terms of radioulnar space available for the repaired biceps. Discussion: This study shows that the space available for the biceps tendon decreases with forearm pronation after reconstruction for all repair techniques. It appears that using suture anchors to repair the biceps tendon may predispose the repaired tendon to impingement when compared with other fixation techniques. (C) 2014 Journal of Shoulder and Elbow Surgery Board of Trustees. C1 [Krueger, Chad A.; Broughton, Kimberly; Rispoli, Damian M.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Aden, James K.] United States Army Inst Surg Res, Ft Sam Houston, TX USA. [Rispoli, Damian M.] WellSpan Hlth, York, PA USA. RP Krueger, CA (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM cak0705@gmail.com NR 31 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 1058-2746 J9 J SHOULDER ELB SURG JI J. Shoulder Elbow Surg. PD NOV PY 2014 VL 23 IS 11 BP 1717 EP 1723 DI 10.1016/j.jse.2014.02.023 PG 7 WC Orthopedics; Sport Sciences; Surgery SC Orthopedics; Sport Sciences; Surgery GA AR8DF UT WOS:000343805000022 PM 24862250 ER PT J AU Derenge, MA Kirchner, KW Jones, KA Suvarna, P Shahedipour-Sandvik, S AF Derenge, Michael A. Kirchner, Kevin W. Jones, Kenneth A. Suvarna, Puneet Shahedipour-Sandvik, Shadi TI Annealing studies of AN capped, MOCVD grown GaN films SO SOLID-STATE ELECTRONICS LA English DT Article; Proceedings Paper CT International Semiconductor Device Research Symposium (ISDRS) CY DEC 11-13, 2013 CL Bethesda, MD DE GaN; AIN; Anneal cap ID CARBON AB An MN annealing cap has been developed for GaN films grown on sapphire substrates that enables them to be annealed at temperatures as high as 1300 degrees C for times as long as 30 min or times as long as 120 min at a temperature of 1150 degrees C without creating a significant number of electrically active N vacancies or new thermal etch pits due to the preferential evaporation of N. However, the pits in the as-grown sample became larger and their sidewalls became steeper, and the flat areas of the film became a little rougher when the annealing time and/or temperature was larger. The films became more relaxed as indicated by a >10% reduction in the X-ray rocking curve peak widths and the creation of a more uniform convex bow. Both the net carrier concentration and electron mobility were reduced by the anneal suggesting that compensating point defects had been created. One possible explanation is that more C in these metal organic chemical vapor deposition (MOCVD) grown films occupied N sites where it is believed to be a deep acceptor. Published by Elsevier Ltd. C1 [Derenge, Michael A.; Kirchner, Kevin W.; Jones, Kenneth A.] Army Res Lab, Adelphi, MD USA. [Suvarna, Puneet; Shahedipour-Sandvik, Shadi] SUNY Albany, Coll Nanoscale Sci & Engn, Albany, NY 12222 USA. RP Derenge, MA (reprint author), US Army Res Lab, RDRL SED E, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM michael.a.derenge.civ@mail.mil NR 22 TC 1 Z9 1 U1 0 U2 28 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0038-1101 EI 1879-2405 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD NOV PY 2014 VL 101 SI SI BP 23 EP 28 DI 10.1016/j.sse.2014.06.027 PG 6 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA AR8PX UT WOS:000343838200006 ER PT J AU Simingalam, S VanMil, BL Chen, YP DeCuir, EA Meissner, GP Wijewarnasuriya, P Dhar, NK Rao, MV AF Simingalam, Sina VanMil, Brenda L. Chen, Yuanping DeCuir, Eric A., Jr. Meissner, Greg P. Wijewarnasuriya, Priyalal Dhar, Nibir K. Rao, Mulpuri V. TI Development and fabrication of extended short wavelength infrared HgCdTe sensors grown on CdTe/Si substrates by molecular beam epitaxy SO SOLID-STATE ELECTRONICS LA English DT Article; Proceedings Paper CT International Semiconductor Device Research Symposium (ISDRS) CY DEC 11-13, 2013 CL Bethesda, MD DE HgCdTe; Short-wavelength infrared; Shunt current; Passivation AB The development and fabrication of extended short-wavelength infrared (SWIR) HgCdTe (MCT) sensors grown on CdTe/Si substrates is reported. The MCT epilayers were grown on CdTe/Si substrates by molecular beam epitaxy (MBE). The epilayers were evaluated using Fourier transform infrared spectroscopy (FTIR), X-ray double crystal rocking curve (DCRC), Van der Pauw Hall measurements, dislocation defect-decoration etching and Nomarski microscopy. The FTIR analysis revealed a cutoff wavelength of 2.25 mu m at 300 K which corresponds to a cadmium composition of 47%. As-grown epilayers have void defect densities less than 10(3) cm(-2) and etch pit densities of similar to 1 x 10(7) cm(-2). The Hall mobilities of annealed MCT samples are on the order of 1500 cm(2)/Vs and have carrier concentrations of similar to 1 x 10(16) cm(-3) at 300 K. Samples were doped in situ with indium (donor) and ion-implanted with arsenic (acceptor) to fabricate p-n diodes with sizes ranging from 15 mu m to 250 mu m diameter. We present the results and analysis of temperature dependent current-voltage (I-V) and quantum efficiency/responsivity measurements on the p-n diodes. In our analysis, we found that the I-V characteristics of small devices were dominated by shunt currents and quantum efficiency is limited by Shockley-Read-Hall (SRH) mechanisms. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Simingalam, Sina] George Mason Univ, Sch Phys Astron & Computat Sci, Fairfax, VA 22030 USA. [Simingalam, Sina; VanMil, Brenda L.; Chen, Yuanping; DeCuir, Eric A., Jr.; Meissner, Greg P.; Wijewarnasuriya, Priyalal] US Army, Res Lab, Atlanta, GA USA. [Dhar, Nibir K.] Def Adv Res Projects Agcy, Microsyst Technol Off, Arlington, VA USA. [Rao, Mulpuri V.] George Mason Univ, Dept Elect & Comp Engn, Fairfax, VA 22030 USA. RP Simingalam, S (reprint author), George Mason Univ, Sch Phys Astron & Computat Sci, Fairfax, VA 22030 USA. EM ssiminga@gmu.edu NR 15 TC 3 Z9 4 U1 1 U2 27 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0038-1101 EI 1879-2405 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD NOV PY 2014 VL 101 SI SI BP 90 EP 94 DI 10.1016/j.sse.2014.06.037 PG 5 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA AR8PX UT WOS:000343838200017 ER PT J AU Faulde, MK Rueda, LM Khaireh, BA AF Faulde, Michael K. Rueda, Leopoldo M. Khaireh, Bouh A. TI First record of the Asian malaria vector Anopheles stephensi and its possible role in the resurgence of malaria in Djibouti, Horn of Africa SO ACTA TROPICA LA English DT Article DE Anopheles stephensi; Invasive species; Plasmodium falciparum malaria; Outbreak; Djibouti ID PLASMODIUM-FALCIPARUM; CULICIDAE; DIPTERA; TRANSMISSION; ELIMINATION; MOSQUITOS; REGION AB Anopheles stephensi is an important vector of urban malaria in India and the Persian Gulf area. Its previously known geographical range includes southern Asia and the Arab Peninsula. For the first time, we report A. stephensi from the African continent, based on collections made in Djibouti, on the Horn of Africa, where this species' occurrence was linked to an unusual urban outbreak of Plasmodium falciparum malaria, with 1228 cases reported from February to May 2013, and a second, more severe epidemic that emerged in November 2013 and resulted in 2017 reported malaria cases between January and February 2014. Anopheles stephensi was initially identified using morphological identification keys, followed by sequencing of the Barcode cytochrome c-oxidase I (COI) gene and the rDNA second internal transcribed spacer (ITS2). Positive tests for P. falciparum circumsporozoite antigen in two of six female A. stephensi trapped in homes of malaria patients in March 2013 are evidence that autochthonous urban malaria transmission by A. stephensi has occurred. Concurrent with the second malaria outbreak, P. falciparum-positive A. stephensi females were detected in Djibouti City starting in November 2013. In sub-Saharan Africa, newly present A. stephensi may pose a significant future health threat because of this species' high susceptibility to P. falciparum infection and its tolerance of urban habitats. This may lead to increased malaria outbreaks in African cities. Rapid interruption of the urban malaria transmission cycle, based on integrated vector surveillance and control programs aimed at the complete eradication of A. stephensi from the African continent, is strongly recommended. (C) 2014 Elsevier B.V. All rights reserved. C1 [Faulde, Michael K.] Cent Inst Bundeswehr Med Serv, Dept Med Entomol Zool, D-56065 Koblenz, Germany. [Faulde, Michael K.] Univ Clin Bonn, Inst Med Microbiol Immunol & Parasitol, D-53105 Bonn, Germany. [Rueda, Leopoldo M.] Walter Reed Army Inst Res, Entomol Branch, Walter Reed Biosystemat Unit, Silver Spring, MD 20910 USA. [Khaireh, Bouh A.] Djiboutian Armed Forces Hlth Serv, Dept Infect Dis Epidemiol & Clin Res, Djibouti City, Djibouti. RP Faulde, MK (reprint author), Cent Inst Bundeswehr Med Serv, Dept Med Entomol Zool, POB 7340, D-56065 Koblenz, Germany. EM MichaelFaulde@bundeswehr.org FU Walter Reed Army Institute of Research; Smithsonian Institution FX We thank Dr. Maysa Motoki, Walter Reed Biosystematics Unit, for overseeing our molecular genetic analysis. Thanks also to the numerous preventive medicine technicians in Djibouti for their assistance in monitoring local mosquito populations. Dr. Richard G. Robbins, Armed Forces Pest Management Board, Office of the Deputy Under Secretary of Defense for Installations and Environment, Washington, DC, helpfully reviewed and commented on an earlier version of our manuscript. This research was supported in part through a Memorandum of Understanding between the Walter Reed Army Institute of Research and the Smithsonian Institution. The opinions and assertions advanced herein are those of the authors and are not to be construed as official or reflecting the views of the U.S. Departments of the Army or Defense. NR 30 TC 6 Z9 6 U1 1 U2 15 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0001-706X EI 1873-6254 J9 ACTA TROP JI Acta Trop. PD NOV PY 2014 VL 139 BP 39 EP 43 DI 10.1016/j.actatropica.2014.06.016 PG 5 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA AR1NQ UT WOS:000343352300006 PM 25004439 ER PT J AU Manrique, A Adams, E Barouch, DH Fast, P Graham, BS Kim, JH Kublin, JG McCluskey, M Pantaleo, G Robinson, HL Russell, N Snow, W Johnston, MI AF Manrique, Amapola Adams, Elizabeth Barouch, Dan H. Fast, Pat Graham, Barney S. Kim, Jerome H. Kublin, James G. McCluskey, Margaret Pantaleo, Giuseppe Robinson, Harriet L. Russell, Nina Snow, William Johnston, Margaret I. TI The Immune Space: A Concept and Template for Rationalizing Vaccine Development SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Editorial Material ID IMMUNODEFICIENCY-VIRUS TYPE-1; B-CELL RECEPTORS; HIV-1; OPTIMIZATION; DESIGN; TRIAL; ASSAY AB Empirical testing of candidate vaccines has led to the successful development of a number of lifesaving vaccines. The advent of new tools to manipulate antigens and new methods and vectors for vaccine delivery has led to a veritable explosion of potential vaccine designs. As a result, selection of candidate vaccines suitable for large-scale efficacy testing has become more challenging. This is especially true for diseases such as dengue, HIV, and tuberculosis where there is no validated animal model or correlate of immune protection. Establishing guidelines for the selection of vaccine candidates for advanced testing has become a necessity. A number of factors could be considered in making these decisions, including, for example, safety in animal and human studies, immune profile, protection in animal studies, production processes with product quality and stability, availability of resources, and estimated cost of goods. The "immune space template" proposed here provides a standardized approach by which the quality, level, and durability of immune responses elicited in early human trials by a candidate vaccine can be described. The immune response profile will demonstrate if and how the candidate is unique relative to other candidates, especially those that have preceded it into efficacy testing and, thus, what new information concerning potential immune correlates could be learned from an efficacy trial. A thorough characterization of immune responses should also provide insight into a developer's rationale for the vaccine's proposed mechanism of action. HIV vaccine researchers plan to include this general approach in up-selecting candidates for the next large efficacy trial. This "immune space" approach may also be applicable to other vaccine development endeavors where correlates of vaccine-induced immune protection remain unknown. C1 [Manrique, Amapola; Snow, William] Global HIV Vaccine Enterprise, New York, NY 10004 USA. [Adams, Elizabeth] NIAID, Div Aids, Bethesda, MD 20892 USA. [Barouch, Dan H.] Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02215 USA. [Fast, Pat] Int AIDS Vaccine Initiat, New York, NY USA. [Graham, Barney S.] NIAID, Vaccine Res Ctr, Bethesda, MD 20892 USA. [Kim, Jerome H.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Kublin, James G.] Fred Hutchinson Canc Res Ctr, HIV Vaccine Trials Network, Seattle, WA 98104 USA. [Kublin, James G.] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Inst, Seattle, WA 98104 USA. [McCluskey, Margaret] USAID, Washington, DC USA. [Pantaleo, Giuseppe] Univ Lausanne, Div Immunol & Allergy, Univ Lausanne Hosp, Lausanne, Switzerland. [Robinson, Harriet L.] GeoVax Inc, Smyrna, GA USA. [Russell, Nina; Johnston, Margaret I.] Bill & Melinda Gates Fdn, Seattle, WA USA. RP Manrique, A (reprint author), Global HIV Vaccine Enterprise, 64 Beaver St,352, New York, NY 10004 USA. EM amanrique@vaccineenterprise.org RI Pantaleo, Giuseppe/K-6163-2016 NR 19 TC 7 Z9 7 U1 2 U2 7 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV 1 PY 2014 VL 30 IS 11 BP 1017 EP 1022 DI 10.1089/aid.2014.0040 PG 6 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AR7OY UT WOS:000343770300001 PM 24857015 ER PT J AU Heavens, KR Kenefick, RW Caruso, EM Spitz, MG Cheuvront, SN AF Heavens, Kristen R. Kenefick, Robert W. Caruso, Elizabeth M. Spitz, Marissa G. Cheuvront, Samuel N. TI Validation of equations used to predict plasma osmolality in a healthy adult cohort SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article ID CALCULATING SERUM OSMOLALITY; SODIUM CONCENTRATION; REGRESSION; WATER; LIMITATIONS; GAPS; DEHYDRATION; OSMOLARITY; OSMOMETRY; FORMULA AB Background: Plasma osmometry and the osmol gap have long been used to provide clinicians with important diagnostic and prognostic patient information. Objective: We compared different equations used for predicting plasma osmolality when its direct measurement was not practical or an osmol gap was of interest and identified the best performers. Design: The osmolality of plasma was measured by using freezing point depression by microosmometer and osmolarity calculated from biosensor measures of select analytes according to the dictates of each formula tested. After a rigid analytic prescreen of 36 originally published equations, a bootstrap regression analysis was used to compare shrinkage and model agreement. Results: Sixty healthy volunteers provided 163 plasma samples for analysis. Of 36 equations considered, 11 equations met the prescreen variables for the bootstrap regression analysis. Of the 11 equations, 8 equations met shrinkage and apparent model error thresholds, and 5 equations were deemed optimal with an original model osmol gap <5 mmol. Conclusions: The use of bootstrap regression provides a unique insight for osmolality prediction equation performance from a very large theoretical population of healthy people. Of the original 36 equations evaluated, 5 equations appeared optimal for the prediction of osmolality when its direct measurement was not practical or an osmol gap was of interest. Note that 4 of 5 optimal equations were derived from a nonhealthy population. C1 [Heavens, Kristen R.; Kenefick, Robert W.; Caruso, Elizabeth M.; Spitz, Marissa G.; Cheuvront, Samuel N.] US Army, Inst Environm Med, Natick, MA 01760 USA. RP Cheuvront, SN (reprint author), US Army, Inst Environm Med, Thermal & Mt Med Div, Kansas St,Bldg 42, Natick, MA 01760 USA. EM samuel.n.cheuvront.civ@mail.mil FU United States Army Medical Research and Materiel Command FX Supported by the United States Army Medical Research and Materiel Command. NR 47 TC 4 Z9 4 U1 0 U2 6 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0002-9165 EI 1938-3207 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD NOV PY 2014 VL 100 IS 5 BP 1252 EP 1256 DI 10.3945/ajcn.114.091009 PG 5 WC Nutrition & Dietetics SC Nutrition & Dietetics GA AR3ZT UT WOS:000343528500006 PM 25332323 ER PT J AU Ward, IM Mortensen, EM Battafarano, DF Frei, CR Mansi, I AF Ward, Ian M. Mortensen, Eric M. Battafarano, Daniel F. Frei, Christopher R. Mansi, Ishak TI Association of Statins and Risk of Fractures in a Military Health System: A Propensity Score-Matched Analysis SO ANNALS OF PHARMACOTHERAPY LA English DT Article DE statin; hip fracture; fractures; observational studies ID COA REDUCTASE INHIBITORS; HIP FRACTURE; POSTMENOPAUSAL WOMEN; CONTROLLED-TRIALS; BONE-DENSITY; OSTEOPOROSIS; POPULATION; EPIDEMIOLOGY; DRUGS AB Background: Contradictory evidence exists regarding statin use and risk of osteoporotic fractures. Objective: The study objective was to examine the effect of statins on fracture risk in a Military Healthcare System (MHS) with similar access and standard of health care for its beneficiaries. Methods: This is a retrospective study of patients enrolled in an MHS encompassing the period from October 1, 2003, to March 1, 2010. Statin users were defined as those receiving a statin for >= 90 days in Fiscal Year 2005, whereas nonusers were defined as individuals not receiving a statin throughout the study period. A propensity score matched cohort of statin users and nonusers was created using 42 variables. The outcomes were identified using ICD-9-CM codes in the follow-up period (October I, 2006, to March 1, 2010). In all, 4 outcomes were examined: all fractures, femoral neck fractures, upper-extremity fractures, and lower-extremity fractures. Results: Of 46 249 patients, 6967 pairs of statin users and nonusers were matched. Statin users had a lower risk of femoral neck fracture in comparison to nonusers (odds ratio = 0.58, 95% CI = 0.36-0.94) but similar risk of all fractures, lower-extremity fractures, and upper-extremity fractures. Conclusions: In this cohort of patients managed in an MHS, statin use was associated with a lower risk of femoral neck fractures, but not all fractures, upper-extremity fractures, or lower-extremity fractures. C1 [Ward, Ian M.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. [Ward, Ian M.] San Antonio Uniformed Serv Hlth Consortium, Ft Sam Houston, TX USA. [Mortensen, Eric M.; Mansi, Ishak] VA North Texas Hlth Care Syst, Dallas, TX 75216 USA. [Mortensen, Eric M.; Mansi, Ishak] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA. [Battafarano, Daniel F.] Brooke Army Med Ctr, San Antonio Uniformed Serv Hlth Educ Consortium, San Antonio, TX USA. [Frei, Christopher R.] Univ Texas Austin, Austin, TX 78712 USA. [Frei, Christopher R.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. RP Mansi, I (reprint author), VA North Texas Hlth Care Syst, 4500 South Lancaster 111E, Dallas, TX 75216 USA. EM Ishak.mansi@va.gov OI Mortensen, Eric/0000-0002-3880-5563 FU US National Institutes of Health (NIH) in the form of a NIH/KL2 career development award [RR025766]; AstraZeneca; Bristol Myers Squibb; Elan; Forest; Ortho-McNeil Janssen; Pfizer FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: No funding was provided for the conduct of this study or the preparation of this article. CRF is supported by the US National Institutes of Health (NIH) in the form of a NIH/KL2 career development award (RR025766). In addition, CRF has received research grants and/or served as a scientific consultant/advisor for AstraZeneca, Bristol Myers Squibb, Elan, Forest, Ortho-McNeil Janssen, and Pfizer. NR 47 TC 3 Z9 3 U1 0 U2 3 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1060-0280 EI 1542-6270 J9 ANN PHARMACOTHER JI Ann. Pharmacother. PD NOV PY 2014 VL 48 IS 11 BP 1406 EP 1414 DI 10.1177/1060028014545038 PG 9 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA AR1PE UT WOS:000343356300001 PM 25070396 ER PT J AU Powell-Dunford, N Quesada, JF Malsby, RF Chou, V Gerhardt, RT Gross, KR Shackelford, SA AF Powell-Dunford, Nicole Quesada, Jose F. Malsby, Robert F. Chou, Victoria Gerhardt, Robert T. Gross, Kirby R. Shackelford, Stacy A. TI Risk Management Analysis of Air Ambulance Blood Product Administration in Combat Operations SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE blood; transfusion; medevac; pre-hospital; resuscitation ID DAMAGE CONTROL RESUSCITATION; MASSIVE TRANSFUSION; FEASIBILITY; AFGHANISTAN; PREDICTION; EVACUATION; CARE; NEED AB Background: Between June October 2012, 61 flight-medic-directed transfusions took place aboard U.S. Army Medical Evacuation (medevac) helicopters in Afghanistan. This represents the initial experience for pre-hospital blood product transfusion by U.S. Army flight medics. Methods: We performed a retrospective review of clinical records, operating guidelines, after-action reviews, decision and information briefs, bimonthly medical conferences, and medevac-related medical records. Results: A successful program was administered at 10 locations across Afghanistan. Adherence to protocol transfusion indications was 97%. There were 61 casualties who were transfused without any known instance of adverse reaction or local blood product wastage. Shock index (heart rate/systolic blood pressure) improved significantly en route, with a median shock index of 1.6 (IQR 1.2-2.0) pre-transfusion and 1.1 (IQR 1.0-1.5) post-transfusion (P < 0.0001). Blood resupply, training, and clinical procedures were standardized across each of the 10 areas of medevac operations. Discussion: Potential risks of medical complications, reverse propaganda, adherence to protocol, and diversion and/or wastage of limited resources were important considerations in the development of the pilot program. Aviation-specific risk mitigation strategies were important to ensure mission success in terms of wastage prevention, standardized operations at multiple locations, and prevention of adverse clinical outcomes. Consideration of aviation risk mitigation strategies may help enable other helicopter emergency medical systems to develop remote pre-hospital transfusion capability. This pilot program provides preliminary evidence that blood product administration by medevac is safe. C1 US Army Hlth Clin, Wahiawa, HI 96786 USA. [Quesada, Jose F.] 440th Blood Support Detachment, Ft Sam Houston, TX USA. Womack Army Med Ctr, Ft Bragg, NC USA. USAF Ctr Sustainment Trauma & Readiness Skills, Baltimore, MD USA. San Antonio Mil Med Ctr, Dept Emergency Med, US Army Inst Surg Res, Ft Sam Houston, TX USA. RP Powell-Dunford, N (reprint author), 1345 Pk Dr, Honolulu, HI 96819 USA. EM nicole.c.powell-dunford.mil@mail.mil NR 22 TC 3 Z9 3 U1 2 U2 10 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 EI 1943-4448 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD NOV PY 2014 VL 85 IS 11 BP 1130 EP 1135 DI 10.3357/ASEM.3851.2014 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA AR5SA UT WOS:000343642500010 PM 25329947 ER PT J AU Harris, KS Adda, CG Khore, M Drew, DR Valentini-Gatt, A Fowkes, FJI Beeson, JG Dutta, S Anders, RF Foley, M AF Harris, Karen S. Adda, Christopher G. Khore, Madhavi Drew, Damien R. Valentini-Gatt, Antonina Fowkes, Freya J. I. Beeson, James G. Dutta, Sheetij Anders, Robin F. Foley, Michael TI Use of Immunodampening To Overcome Diversity in the Malarial Vaccine Candidate Apical Membrane Antigen 1 SO INFECTION AND IMMUNITY LA English DT Article ID PLASMODIUM-FALCIPARUM APICAL-MEMBRANE-ANTIGEN-1; ALLELE-SPECIFIC EFFICACY; INHIBITORY ANTIBODY; PHAGE DISPLAY; AMA1; SPECIFICITY; SELECTION; IMMUNIZATION; PROTECTION; RESPONSES AB Apical membrane antigen 1 (AMA1) is a leading malarial vaccine candidate; however, its polymorphic nature may limit its success in the field. This study aimed to circumvent AMA1 diversity by dampening the antibody response to the highly polymorphic loop Id, previously identified as a major target of strain-specific, invasion-inhibitory antibodies. To achieve this, five polymorphic residues within this loop were mutated to alanine, glycine, or serine in AMA1 of the 3D7 and FVO Plasmodium falciparum strains. Initially, the corresponding antigens were displayed on the surface of bacteriophage, where the alanine and serine but not glycine mutants folded correctly. The alanine and serine AMA1 mutants were expressed in Escherichia coli, refolded in vitro, and used to immunize rabbits. Serological analyses indicated that immunization with a single mutated form of 3D7 AMA1 was sufficient to increase the cross-reactive antibody response. Targeting the corresponding residues in an FVO backbone did not achieve this outcome. The inclusion of at least one engineered form of AMA1 in a biallelic formulation resulted in an antibody response with broader reactivity against different AMA1 alleles than combining the wild-type forms of 3D7 and FVO AMA1 alleles. For one combination, this extended to an enhanced relative growth inhibition of a heterologous parasite line, although this was at the cost of reduced overall inhibitory activity. These results suggest that targeted mutagenesis of AMA1 is a promising strategy for overcoming antigenic diversity in AMA1 and reducing the number of variants required to induce an antibody response that protects against a broad range of Plasmodium falciparum AMA1 genotypes. However, optimization of the immunization regime and mutation strategy will be required for this potential to be realized. C1 [Harris, Karen S.; Adda, Christopher G.; Khore, Madhavi; Valentini-Gatt, Antonina; Anders, Robin F.; Foley, Michael] La Trobe Univ, La Trobe Inst Mol Sci, Dept Biochem, Melbourne, Vic, Australia. [Drew, Damien R.; Fowkes, Freya J. I.; Beeson, James G.] Burnet Inst, Ctr Biomed Res, Melbourne, Vic, Australia. [Dutta, Sheetij] Walter Reed Army Inst Res, Dept Struct Vaccinol, Malaria Vaccine Branch, Silver Spring, MD USA. RP Foley, M (reprint author), La Trobe Univ, La Trobe Inst Mol Sci, Dept Biochem, Melbourne, Vic, Australia. EM m.foley@latrobe.edu.au OI Adda, Christopher/0000-0002-0905-8909 FU National Institutes of Health (NIH) [R01AI59229]; National Health and Medical Research Council of Australia; Australian Research Council; Victorian State Government; PATH Malaria Vaccine Initiative; U.S. Agency for International Development FX Funding was provided by the National Institutes of Health (NIH) (grant R01AI59229 to M. F.), the National Health and Medical Research Council of Australia (senior research fellowship, project grant, and Infrastructure for Research Institutes Support Scheme grant to J.G.B.), the Australian Research Council (future fellowship to J.G.B.), a Victorian State Government operational infrastructure support grant, the PATH Malaria Vaccine Initiative, and the U.S. Agency for International Development. NR 42 TC 4 Z9 4 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 EI 1098-5522 J9 INFECT IMMUN JI Infect. Immun. PD NOV PY 2014 VL 82 IS 11 BP 4707 EP 4717 DI 10.1128/IAI.02061-14 PG 11 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AR4UQ UT WOS:000343582900026 PM 25156737 ER PT J AU McDaniel, JS Pilia, M Ward, CL Pollot, BE Rathbone, CR AF McDaniel, Jennifer S. Pilia, Marcello Ward, Catherine L. Pollot, Beth E. Rathbone, Christopher R. TI Characterization and multilineage potential of cells derived from isolated microvascular fragments SO JOURNAL OF SURGICAL RESEARCH LA English DT Article DE Microvessel; Mesenchymal stem cell; Angiogenesis ID MUSCLE SATELLITE CELL; HUMAN ADIPOSE-TISSUE; ENDOTHELIAL-CELLS; STEM-CELLS; MICROVESSEL FRAGMENTS; SELF-RENEWAL; VASCULARIZATION; PERICYTES; CULTURE; GRAFTS AB Background: A number of therapies are being developed that use microvessels isolated from adipose tissue (microvascular fragments [MVFs]) to improve tissue perfusion and implant survival. Because it has been demonstrated that stem cells are associated with microvessels, the purpose of these studies was to gain further insight into the stem cells associated with MVFs to better understand their therapeutic potential. Materials and methods: Cells derived from MVF explants were compared with adipose-derived stem cells (ASCs) based on the expression of cell surface proteins for mesenchymal stemcells and their capacity for angiogenic, neurogenic, adipogenic, and osteogenic differentiation. Results: The expression of cell surface proteins for mesenchymal stem cell markers was similar between MVF-derived cells and ASCs; however, the increase in markers consistent with endothelial cells and pericytes was accompanied by an improved ability to form capillary-like networks when cultured on matrigel. MVF-derived cells had increased neuregulin, leptin, and osteopontin expression compared with ASCs when exposed to neurogenic, adipogenic, and osteogenic induction media, respectively. Conclusions: The stem cell functionality of cells derived from MVFs is retained after their isolation. This helps to explain the ability of MVFs to improve tissue perfusion and has implications for the use of MVFs as a means to deliver stem cells within their niche. Published by Elsevier Inc. C1 [McDaniel, Jennifer S.; Pilia, Marcello; Ward, Catherine L.; Pollot, Beth E.; Rathbone, Christopher R.] US Army, Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, Ft Sam Houston, TX 78234 USA. [Pollot, Beth E.] Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX USA. RP Rathbone, CR (reprint author), US Army, Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, 3698 Chambers Pass BLDG 3611, Ft Sam Houston, TX 78234 USA. EM christopher.r.rathbone.civ@mail.mil FU US Army Medical Research and Materiel Command of the Department of Defense FX This study was supported by the US Army Medical Research and Materiel Command of the Department of Defense. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or reflecting the views of the Department of Defense or US government. The authors would like to express our sincere gratitude to Monica Jalomo and Stephanie Roth for their invaluable technical assistance. NR 31 TC 6 Z9 6 U1 0 U2 7 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-4804 EI 1095-8673 J9 J SURG RES JI J. Surg. Res. PD NOV PY 2014 VL 192 IS 1 BP 214 EP 222 DI 10.1016/j.jss.2014.05.047 PG 9 WC Surgery SC Surgery GA AR2FY UT WOS:000343400300030 PM 24969547 ER PT J AU Hraber, P Korber, BT Lapedes, AS Bailer, RT Seaman, MS Gao, H Greene, KM McCutchan, F Williamson, C Kim, JH Tovanabutra, S Hahn, BH Swanstrom, R Thomson, MM Gao, F Harris, L Giorgi, E Hengartner, N Bhattacharya, T Mascola, JR Montefiori, DC AF Hraber, Peter Korber, Bette T. Lapedes, Alan S. Bailer, Robert T. Seaman, Michael S. Gao, Hongmei Greene, Kelli M. McCutchan, Francine Williamson, Carolyn Kim, Jerome H. Tovanabutra, Sodsai Hahn, Beatrice H. Swanstrom, Ronald Thomson, Michael M. Gao, Feng Harris, Linda Giorgi, Elena Hengartner, Nicholas Bhattacharya, Tanmoy Mascola, John R. Montefiori, David C. TI Impact of Clade, Geography, and Age of the Epidemic on HIV-1 Neutralization by Antibodies SO JOURNAL OF VIROLOGY LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; INJECTION-DRUG USERS; B-CELL RECEPTORS; EFFICACY TRIAL; ENVELOPE GLYCOPROTEINS; VACCINE DEVELOPMENT; IMMUNOGEN DESIGN; STRUCTURAL BASIS; FOUNDER VIRUS; ENV CLONES AB Neutralizing antibodies (nAbs) are a high priority for vaccines that aim to prevent the acquisition of HIV-1 infection. Vaccine effectiveness will depend on the extent to which induced antibodies neutralize the global diversity of circulating HIV-1 variants. Using large panels of genetically and geographically diverse HIV-1 Env-pseudotyped viruses and chronic infection plasma samples, we unambiguously show that cross-clade nAb responses are commonly induced in response to infection by any virus clade. Nonetheless, neutralization was significantly greater when the plasma clade matched the clade of the virus being tested. This within-clade advantage was diminished in older, more-diverse epidemics in southern Africa, the United States, and Europe compared to more recent epidemics in Asia. It was most pronounced for circulating recombinant form (CRF) 07_BC, which is common in China and is the least-divergent lineage studied; this was followed by the slightly more diverse Asian CRF01_AE. We found no evidence that transmitted/founder viruses are generally more susceptible to neutralization and are therefore easier targets for vaccination than chronic viruses. Features of the gp120 V1V2 loop, in particular, length, net charge, and number of N-linked glycans, were associated with Env susceptibility and plasma neutralization potency in a manner consistent with neutralization escape being a force that drives viral diversification and plasma neutralization breadth. The overall susceptibility of Envs and potencies of plasma samples were highly predictive of the neutralization outcome of any single virus-plasma combination. These findings highlight important considerations for the design and testing of candidate HIV-1 vaccines that aim to elicit effective nAbs. IMPORTANCE An effective HIV-1 vaccine will need to overcome the extraordinary variability of the virus, which is most pronounced in the envelope glycoproteins (Env), which are the sole targets for neutralizing antibodies (nAbs). Distinct genetic lineages, or clades, of HIV-1 occur in different locales that may require special consideration when designing and testing vaccines candidates. We show that nAb responses to HIV-1 infection are generally active across clades but are most potent within clades. Because effective vaccine-induced nAbs are likely to share these properties, optimal coverage of a particular clade or combination of clades may require clade-matched immunogens. Optimal within-clade coverage might be easier to achieve in regions such as China and Thailand, where the epidemic is more recent and the virus less diverse than in southern Africa, the United States, and Europe. Finally, features of the first and second hypervariable regions of gp120 (V1V2) may be critical for optimal vaccine design. C1 [Hraber, Peter; Korber, Bette T.; Lapedes, Alan S.; Giorgi, Elena; Hengartner, Nicholas; Bhattacharya, Tanmoy] Los Alamos Natl Lab, Los Alamos, NM 87544 USA. [Korber, Bette T.] New Mexico Consortium, Los Alamos, NM USA. [Bailer, Robert T.; Mascola, John R.] NIH, Vaccine Res Ctr, Bethesda, MD 20892 USA. [Seaman, Michael S.] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. [Gao, Hongmei; Greene, Kelli M.; Gao, Feng; Montefiori, David C.] Duke Univ, Med Ctr, Durham, NC USA. [McCutchan, Francine; Kim, Jerome H.; Tovanabutra, Sodsai] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Williamson, Carolyn] Univ Cape Town, Inst Infect Dis & Mol Med, ZA-7925 Cape Town, South Africa. [Hahn, Beatrice H.] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA. [Swanstrom, Ronald] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC USA. [Thomson, Michael M.] Inst Salud Carlos III, Ctr Nacl Microbiol, Madrid, Spain. [Harris, Linda] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Bhattacharya, Tanmoy] Santa Fe Inst, Santa Fe, NM 87501 USA. RP Montefiori, DC (reprint author), Los Alamos Natl Lab, Los Alamos, NM 87544 USA. EM david.montefiori@duke.edu RI Bhattacharya, Tanmoy/J-8956-2013; OI Bhattacharya, Tanmoy/0000-0002-1060-652X; , Carolyn/0000-0003-0125-1226; Korber, Bette/0000-0002-2026-5757; Hraber, Peter/0000-0002-2920-4897 FU Bill & Melinda Gates Foundation [38619, 1032144] FX This work was funded by grants from the Bill & Melinda Gates Foundation, which established the Comprehensive Antibody Vaccine Immune Monitoring Consortium as part of the Collaboration for AIDS Vaccine Discovery (grants 38619 and 1032144). NR 111 TC 17 Z9 17 U1 1 U2 7 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X EI 1098-5514 J9 J VIROL JI J. Virol. PD NOV PY 2014 VL 88 IS 21 BP 12623 EP 12643 DI 10.1128/JVI.01705-14 PG 21 WC Virology SC Virology GA AR1BN UT WOS:000343314900038 PM 25142591 ER PT J AU Streeck, H Lu, R Beckwith, N Milazzo, M Liu, M Routy, JP Little, S Jessen, H Kelleher, AD Hecht, F Sekaly, RP Alter, G Heckerman, D Carrington, M Rosenberg, ES Altfeld, M AF Streeck, Hendrik Lu, Richard Beckwith, Noor Milazzo, Mark Liu, Michelle Routy, Jean-Pierre Little, Susan Jessen, Heiko Kelleher, Anthony D. Hecht, Frederick Sekaly, Rafick-Pierre Alter, Galit Heckerman, David Carrington, Mary Rosenberg, Eric S. Altfeld, Marcus TI Emergence of Individual HIV-Specific CD8 T Cell Responses during Primary HIV-1 Infection Can Determine Long-Term Disease Outcome SO JOURNAL OF VIROLOGY LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; VIRAL LOAD; LYMPHOCYTE ESCAPE; TYPE-1 INFECTION; SET-POINT; AIDS; PROGRESSION; VIREMIA; EPITOPE; GAG AB Events during primary HIV-1 infection have been shown to be critical for the subsequent rate of disease progression. Early control of viral replication, resolution of clinical symptoms and development of a viral set point have been associated with the emergence of HIV-specific CD8 T cell responses. Here we assessed which particular HIV-specific CD8 T cell responses contribute to long-term control of HIV-1. A total of 620 individuals with primary HIV-1 infection were screened by gamma interferon (IFN-gamma) enzyme-linked immunospot (ELISPOT) assay for HLA class I-restricted, epitope-specific CD8 T cell responses using optimally defined epitopes approximately 2 months after initial presentation. The cohort was predominantly male (97%) and Caucasian (83%) (Fiebig stages II/III [n = 157], IV [n = 64], V [n = 286], and VI [n = 88] and Fiebig stage not determined [n = 25]). Longitudinal viral loads, CD4 count, and time to ART were collected for all patients. We observed strong associations between viral load at baseline (initial viremia) and the established early viral set points (P < 0.0001). Both were significantly associated with HLA class I genotypes (P = 0.0009). While neither the breadth nor the magnitude of HIV-specific CD8 T cell responses showed an influence on the early viral set point, a broader HIV-specific CD8 T cell response targeting epitopes within HIV-1 Gag during primary HIV-1 infection was associated with slower disease progression. Moreover, the induction of certain HIV-specific CD8 T cell responses-but not others-significantly influenced the time to ART initiation. Individual epitope-specific CD8 T cell responses contribute significantly to HIV-1 disease control, demonstrating that the specificity of the initial HIV-specific CD8 T cell response rather than the restricting HLA class I molecule alone is a critical determinant of antiviral function. IMPORTANCE Understanding which factors are involved in the control of HIV-1 infection is critical for the design of therapeutic strategies for patients living with HIV/AIDS. Here, using a cohort of over 600 individuals with acute and early HIV-1 infection, we assessed in unprecedented detail the individual contribution of epitope-specific CD8 T cell responses directed against HIV-1 to control of viremia and their impact on the overall course of disease progression. C1 [Streeck, Hendrik; Lu, Richard; Milazzo, Mark; Liu, Michelle] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Streeck, Hendrik; Lu, Richard; Milazzo, Mark; Liu, Michelle] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Streeck, Hendrik; Alter, Galit; Carrington, Mary; Altfeld, Marcus] Ragon Inst MGH MIT & Harvard, Cambridge, MA 02139 USA. [Beckwith, Noor] Harvard Univ, Sch Med, Boston, MA USA. [Routy, Jean-Pierre] McGill Univ, Div Hematol, Montreal, PQ, Canada. [Routy, Jean-Pierre] McGill Univ, Royal Victoria Hosp, Immunodeficiency Serv, Montreal, PQ H3A 1A1, Canada. [Little, Susan] Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA. [Jessen, Heiko] HIV Clin Praxis Jessen, Berlin, Germany. [Kelleher, Anthony D.] UNSW, Kirby Inst, Sydney, NSW, Australia. [Hecht, Frederick] Univ Calif San Francisco, Dept Med, San Francisco Gen Hosp, San Francisco, CA USA. [Sekaly, Rafick-Pierre] Vaccine & Gene Therapy Inst Florida, Div Infect Dis, Port St Lucie, FL USA. [Heckerman, David] Microsoft Res, eSci Grp, Los Angeles, CA USA. [Carrington, Mary] Leidos Biomedical Res Inc, Frederick Natl Lab Canc Res, Expt Immunol Lab, Canc & Inflammat Program, Frederick, MD USA. [Rosenberg, Eric S.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Altfeld, Marcus] Heinrich Pette Inst, Hamburg, Germany. RP Streeck, H (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. EM hstreeck@hivresearch.org OI Beckwith, Noor/0000-0001-6025-8642 FU NIH [P01 AI074415]; CIHR CTN/HIV trial network [CTN 247]; FRQ-S SIDA/maladies infectieuses; U.S. National Institutes of Health (NIH) [R01 AI091450-01, R01 AI094602-01]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-11-2-0174]; U.S. Department of Defense (DOD); Frederick National Laboratory for Cancer Research [HHSN261200800001E]; Intramural Research Program of the NIH, Frederick National Lab, Center for Cancer Research FX This study was supported in part by NIH P01 AI074415 and in part by CIHR CTN/HIV trial network (CTN 247) and FRQ-S SIDA/maladies infectieuses. H. S. is funded by the U.S. National Institutes of Health (NIH) (R01 AI091450-01 and R01 AI094602-01) and a cooperative agreement (W81XWH-11-2-0174) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD). This project was also funded in whole or in part by federal funds from the Frederick National Laboratory for Cancer Research, under contract no. HHSN261200800001E. This research was supported in part by the Intramural Research Program of the NIH, Frederick National Lab, Center for Cancer Research. NR 31 TC 7 Z9 7 U1 0 U2 9 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X EI 1098-5514 J9 J VIROL JI J. Virol. PD NOV PY 2014 VL 88 IS 21 BP 12793 EP 12801 DI 10.1128/JVI.02016-14 PG 9 WC Virology SC Virology GA AR1BN UT WOS:000343314900051 PM 25165102 ER PT J AU Gaffney-Stomberg, E Lutz, LJ Rood, JC Cable, SJ Pasiakos, SM Young, AJ McClung, JP AF Gaffney-Stomberg, Erin Lutz, Laura J. Rood, Jennifer C. Cable, Sonya J. Pasiakos, Stefan M. Young, Andrew J. McClung, James P. TI Calcium and vitamin D supplementation maintains parathyroid hormone and improves bone density during initial military training: A randomized, double-blind, placebo controlled trial SO BONE LA English DT Article DE Nutrition; Bone; Peripheral QCT; Exercise; Calcium; Vitamin D ID PREDICTING BODY DENSITY; STRESS-FRACTURES; GENERALIZED EQUATIONS; MINERAL DENSITY; PERIPHERAL QCT; RISK-FACTORS; WOMEN; RECRUITS; MEN; STRENGTH AB Calcium and vitamin D are essential nutrients for bone health. Periods of activity with repetitive mechanical loading, such as military training, may result in increases in parathyroid hormone (PTH), a key regulator of Ca metabolism, and may be linked to the development of stress fractures. Previous studies indicate that consumption of a Ca and vitamin D supplement may reduce stress fracture risk in female military personnel during initial military training, but circulating markers of Ca and bone metabolism and measures of bone density and strength have not been determined. This randomized, double-blind, placebo-controlled trial sought to determine the effects of providing supplemental Ca and vitamin D (Ca + Vit D, 2000 mg and 1000 IU/d, respectively), delivered as 2 snack bars per day throughout 9 weeks of Army initial military training (or basic combat training, BCT) on PTH, vitamin status, and measures of bone density and strength in personnel undergoing BCT, as well as independent effects of BCT on bone parameters. A total of 156 men and 87 women enrolled in Army BCT (Fort Sill, OK; 34.7 degrees N latitude) volunteered for this study. Anthropometric, biochemical, and dietary intake data were collected pre- and post-BCT. In addition, peripheral quantitative computed tomography was utilized to assess tibia bone density and strength in a subset of volunteers (n = 46). Consumption of supplemental Ca + Vit D increased circulating ionized Ca (group-by-time, P = 0.022), maintained PTH (group-by-time, P = 0.032), and increased the osteoprotegerin:RANKL ratio (group-by-time, P = 0.006). Consistent with the biochemical markers, Ca + Vit D improved vBMD (group-by-time, P = 0.024) at the 4% site and cortical BMC (group-by-time, P = 0.028) and thickness (group-by-time, P = 0.013) at the 14% site compared to placebo. These data demonstrate the benefit of supplemental Ca and vitamin D for maintaining bone health during periods of elevated bone turnover, such as initial military training. This trial was registered with ClincialTrials.gov, NCT01617109. Published by Elsevier Inc. C1 [Gaffney-Stomberg, Erin; Lutz, Laura J.; Pasiakos, Stefan M.; Young, Andrew J.; McClung, James P.] US Army, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Rood, Jennifer C.] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA. [Cable, Sonya J.] Initial Mil Training Ctr Excellence, Fort Eustis, VA 23604 USA. RP McClung, JP (reprint author), 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM james.mcclung3@us.army.mil RI Pasiakos, Stefan/E-6295-2014 OI Pasiakos, Stefan/0000-0002-5378-5820 FU U.S. Army Medical Research Institute of Environmental Medicine; Defense Health Program [13290]; USAMRMC FX This research was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Medical Research Institute of Environmental Medicine administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USAMRMC. This work was also supported by a grant from the Defense Health Program (13290) and the USAMRMC. The granting agencies were not involved in the study design, data collection, analysis or interpretation, or writing and publishing of this manuscript. NR 36 TC 9 Z9 9 U1 0 U2 14 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 8756-3282 EI 1873-2763 J9 BONE JI Bone PD NOV PY 2014 VL 68 BP 46 EP 56 DI 10.1016/j.bone.2014.08.002 PG 11 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA AQ9SD UT WOS:000343195100007 PM 25118085 ER PT J AU Ersal, T Brudnak, M Salvi, A Kim, Y Siegel, JB Stein, JL AF Ersal, Tulga Brudnak, Mark Salvi, Ashwin Kim, Youngki Siegel, Jason B. Stein, Jeffrey L. TI An Iterative Learning Control Approach to Improving Fidelity in Internet-Distributed Hardware-in-the-Loop Simulation SO JOURNAL OF DYNAMIC SYSTEMS MEASUREMENT AND CONTROL-TRANSACTIONS OF THE ASME LA English DT Article DE real-time simulation; HIL simulation; networked simulation; internet; fidelity; ILC ID BILATERAL TELEOPERATION; TELEMANIPULATION; TRANSPARENCY; STABILITY; SYSTEMS; DESIGN; MANIPULATORS; ROBUSTNESS; DYNAMICS; VEHICLE AB One of the main challenges of cosimulating hardware-in-the-loop (HIL) systems in real-time over the Internet is the fidelity of the simulation. The dynamics of the Internet may significantly distort the dynamics of the network-integrated system. This paper presents the development and experimental validation of an iterative learning control (ILC) based approach to improve fidelity of such networked system integration. Toward this end, a new metric for characterizing coupling fidelity is proposed, which, unlike some existing metrics, enables the formulation of the problem of improving system fidelity without requiring any knowledge about the reference dynamics (i.e., dynamics that would be observed, if the system was physically connected). Next, using this metric, the problem of improving fidelity is formulated as an ILC problem. The proposed approach is illustrated on an experimental setup simulating a hybrid electric powertrain distributed across three different sites with a real engine and battery in the loop. The conclusion is that the proposed approach holds significant potential for achieving high fidelity in Internet-distributed HIL (ID-HIL) simulation setups. C1 [Ersal, Tulga; Salvi, Ashwin; Kim, Youngki; Siegel, Jason B.; Stein, Jeffrey L.] Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA. [Brudnak, Mark] US Army Tank Automot Res, Ctr Dev & Engn, Warren, MI 48397 USA. RP Ersal, T (reprint author), Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA. EM tersal@umich.edu; mark.j.brudnak.civ@mail.mil; asalvi@umich.edu; youngki@umich.edu; siegeljb@umich.edu; stein@umich.edu FU Automotive Research Center (ARC); U.S. Army Tank Automotive Research, Development and Engineering Center (TARDEC) Warren, MI [W56HZV-04-2-0001] FX The authors wish to acknowledge the financial support of the Automotive Research Center (ARC) in accordance with Cooperative Agreement W56HZV-04-2-0001 U.S. Army Tank Automotive Research, Development and Engineering Center (TARDEC) Warren, MI. NR 60 TC 1 Z9 1 U1 2 U2 19 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0022-0434 EI 1528-9028 J9 J DYN SYST-T ASME JI J. Dyn. Syst. Meas. Control-Trans. ASME PD NOV PY 2014 VL 136 IS 6 AR 061012 DI 10.1115/1.4027868 PG 8 WC Automation & Control Systems; Instruments & Instrumentation SC Automation & Control Systems; Instruments & Instrumentation GA AQ8DW UT WOS:000343054900012 ER PT J AU Ladner, JT Wiley, MR Palacios, G AF Ladner, Jason T. Wiley, Michael R. Palacios, Gustavo TI Reply to "Expanding the Conversation on High-Throughput Virome Sequencing Standards To Include Consideration of Microbial Contamination Sources" SO MBIO LA English DT Editorial Material C1 [Ladner, Jason T.; Wiley, Michael R.; Palacios, Gustavo] US Army Med Res Inst Infect Dis, Ctr Genome Sci, Ft Detrick, MD 21702 USA. RP Ladner, JT (reprint author), US Army Med Res Inst Infect Dis, Ctr Genome Sci, Ft Detrick, MD 21702 USA. EM jtladner@gmail.com RI Palacios, Gustavo/I-7773-2015 OI Palacios, Gustavo/0000-0001-5062-1938 NR 3 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 2150-7511 J9 MBIO JI mBio PD NOV-DEC PY 2014 VL 5 IS 6 AR e02084-14 DI 10.1128/mBio.02084-14 PG 1 WC Microbiology SC Microbiology GA AX7CE UT WOS:000347073600039 PM 25352625 ER PT J AU McClure, JP Jiang, RZ Chu, D Fedkiw, PS AF McClure, Joshua P. Jiang, Rongzhong Chu, Deryn Fedkiw, Peter S. TI Oxygen electroreduction on Fe- or Co-containing carbon fibers SO CARBON LA English DT Article ID ELECTROLYTE FUEL-CELLS; REDUCTION REACTION; ALKALINE MEDIA; NITROGEN FUNCTIONALITIES; DISK ELECTRODE; CATALYSTS; ELECTROCATALYSTS; PYROLYSIS; GRAPHENE; METAL AB Non-noble metal-containing electrocatalysts were prepared by an electrospinning method and evaluated as oxygen reduction electrocatalysts. Fe- or Co-containing carbon fibers were prepared by pyrolyzing electrospun polyacrylonitrile (PAN) fibers containing the respective metal precursor and are denoted Fe-PAN and Co-PAN, respectively. The Fe- or Co-PAN carbon fibers were acid-leached and subjected to a second pyrolysis, whereby the final fibers were found to be uniform in diameter with roughened surfaces. Scanning transmission electron microscopy equipped with energy dispersive spectroscopy area-mapping identified Fe or Co nanoparticulates throughout the fiber with a distribution of particulate sizes. X-ray diffractograms (XRD) revealed amorphous Fe-PAN and Co-PAN carbon fibers with no discernible Fe or Co phases, whereas high-resolution XPS scans show a range of potential Fe or Co species. Moreover, the high-resolution X-ray photoelectron spectroscopy (XPS) and peak-fitting analysis provided chemical species information for the C1s, N1s, Fe2p and Co2p regions. The physical characterizations highlighted potential beneficial components for the electrocatalysts that made their use as oxygen reduction reaction (ORR) effective. Rotating disk and ring-disk electrode experiments determined that the best Fe-PAN sample out-performed the best Co-PAN sample and even performed well in comparison to a commercial Pt/C electrocatalyst for the ORR in a high pH media. Published by Elsevier Ltd. C1 [McClure, Joshua P.; Fedkiw, Peter S.] N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA. [McClure, Joshua P.; Jiang, Rongzhong; Chu, Deryn] US Army Res Lab, Adelphi, MD USA. RP Fedkiw, PS (reprint author), N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA. EM joshua.p.mcclure6.civ@mail.mil; fedkiw@ncsu.edu FU DoD Science, Mathematics and Research for Transformation (SMART) fellowship program; U.S. Department of the Army; U.S. Army Materiel Command FX We would like to thank the DoD Science, Mathematics and Research for Transformation (SMART) fellowship program for providing a fellowship to Joshua McClure. Thanks to NC State's Analytical Instrument Facility for VP-SEM and XPS equipment availability. Thanks to Dr. Saad Khan for providing access and assistance with electrospinning equipment and facilities. Thanks to Dr. Shengyang Huang for discussions and assistance with XRD measurements. Finally, thanks to the U.S. Department of the Army and U.S. Army Materiel Command for supporting this research. NR 50 TC 6 Z9 6 U1 16 U2 138 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0008-6223 EI 1873-3891 J9 CARBON JI Carbon PD NOV PY 2014 VL 79 BP 457 EP 469 DI 10.1016/j.carbon.2014.08.005 PG 13 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA AQ2YY UT WOS:000342657100048 ER PT J AU Benson, JD Bubulac, LO Smith, PJ Jacobs, RN Markunas, JK Jaime-Vasquez, M Almeida, LA Stoltz, A Wijewarnasuriya, PS Brill, G Chen, Y Peterson, J Reddy, M Vilela, MF Johnson, SM Lofgreen, DD Yulius, A Bostrup, G Carmody, M Lee, D Couture, S AF Benson, J. D. Bubulac, L. O. Smith, P. J. Jacobs, R. N. Markunas, J. K. Jaime-Vasquez, M. Almeida, L. A. Stoltz, A. Wijewarnasuriya, P. S. Brill, G. Chen, Y. Peterson, J. Reddy, M. Vilela, M. F. Johnson, S. M. Lofgreen, D. D. Yulius, A. Bostrup, G. Carmody, M. Lee, D. Couture, S. TI Impact of Tellurium Precipitates in CdZnTe Substrates on MBE HgCdTe Deposition SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE HgCdTe/CdZnTe; molecular beam epitaxy; Te precipitate; macro- and micro-defects ID MOLECULAR-BEAM EPITAXY; RECENT PROGRESS; GROWTH; THERMOMIGRATION; MACRODEFECTS; MICROSCOPY; TE AB State-of-the-art (112)B CdZnTe substrates were examined for near-surface tellurium precipitate-related defects. The Te precipitate density was observed to be fairly uniform throughout the bulk of the wafer, including the near-surface region. After a molecular beam epitaxy (MBE) preparation etch, exposed Te precipitates, small pits, and bumps on the (112)B surface of the CdZnTe wafer were observed. From near-infrared and dark field microscopy, the bumps and small pits on the CdZnTe surface are associated with strings of Te precipitates. Raised bumps are Te precipitates near the surface of the (112)B CdZnTe where the MBE preparation etch has not yet exposed the Te precipitate(s). An exposed Te precipitate sticking above the etched CdZnTe surface plane occurs when the MBE preparation etch rapidly undercuts a Te precipitate. Shallow surface pits are formed when the Te precipitate is completely undercut from the surrounding (112)B surface plane. The Te precipitate that was previously located at the center of the pit is liberated by the MBE preparation etch process. C1 [Benson, J. D.; Bubulac, L. O.; Smith, P. J.; Jacobs, R. N.; Markunas, J. K.; Jaime-Vasquez, M.; Almeida, L. A.; Stoltz, A.] US Army RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. [Wijewarnasuriya, P. S.; Brill, G.; Chen, Y.] US Army Res Lab, Adelphi, MD USA. [Peterson, J.; Reddy, M.; Vilela, M. F.; Johnson, S. M.; Lofgreen, D. D.] Raytheon Vis Syst, Goleta, CA USA. [Yulius, A.; Bostrup, G.; Carmody, M.; Lee, D.; Couture, S.] Teledyne Imaging Sensors, Camarillo, CA USA. RP Benson, JD (reprint author), US Army RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. EM david.j.benson@us.army.mil NR 23 TC 3 Z9 3 U1 1 U2 20 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD NOV PY 2014 VL 43 IS 11 BP 3993 EP 3998 DI 10.1007/s11664-014-3338-4 PG 6 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA AQ0TE UT WOS:000342494800015 ER PT J AU Sun, WB Lin, B Baize, RR Videen, G Hu, YX AF Sun, Wenbo Lin, Bing Baize, Rosemary R. Videen, Gorden Hu, Yongxiang TI Sensing Hadley cell with space-borne lidar SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article DE Expansion of Hadley cell; Uppermost super-thin clouds; Climate; Space-borne lidar ID CLOUDS; CIRRUS; TROPOPAUSE; MISSION; MODIS; CERES AB Some recent studies reported expansion of the Earth's tropical regime in the past few decades. The poleward expansion of the Hadley cell is a strong indication of the warming of the globe. The extent of Hadley cell also has very important implications to the climate of dry subtropical regions because of the prevalence of precipitation in the deep tropical belt. Determination of the Hadley circulation especially its extent has great significance for monitoring global climate change and for the subtropical climate studies. Although many methods have been developed in recent years, reliable measurement of the extent of Hadley cell is still an issue in climate studies. This letter shows that the extent of the Hadley cell could reliably be estimated by measuring the height of the uppermost super-thin clouds in the troposphere with space-borne lidar. Through consecutive multi-year measurements of the height of the uppermost super-thin clouds, a good estimation of the expansion of the Hadley cell could be obtained. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Sun, Wenbo] Sci Syst & Applicat Inc, Hampton, VA 23666 USA. [Sun, Wenbo; Lin, Bing; Baize, Rosemary R.; Hu, Yongxiang] NASA Langley Res Ctr, Hampton, VA 23681 USA. [Videen, Gorden] Space Sci Inst, Boulder, CO 80301 USA. [Videen, Gorden] Army Res Lab, Adelphi, MD 20783 USA. RP Sun, WB (reprint author), NASA Langley Res Ctr, Mail Stop 420,21 Langley Blvd, Hampton, VA 23681 USA. EM wenbo.sun-1@nasa.gov RI Hu, Yongxiang/K-4426-2012; Richards, Amber/K-8203-2015 FU NASA Glory fund [09-GLORY09-0027]; NASA CLARREO Mission FX This work was supported by NASA Glory fund 09-GLORY09-0027 and also partially supported by NASA CLARREO Mission. The authors thank Hal B. Maring, Michael I. Mishchenko, Bruce A. Wielicki, and David F. Young for these supports. NR 26 TC 1 Z9 1 U1 0 U2 16 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 EI 1879-1352 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD NOV PY 2014 VL 148 BP 38 EP 41 DI 10.1016/j.jqsrt.2014.06.017 PG 4 WC Optics; Spectroscopy SC Optics; Spectroscopy GA AP7JR UT WOS:000342254100006 ER PT J AU Clayton, JD AF Clayton, J. D. TI Finite strain analysis of shock compression of brittle solids applied to titanium diboride SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Ceramics; Shock physics; Plasticity; Damage; Finite strain ID DYNAMIC PLASTICITY; FRACTURE; DEFORMATION; STRENGTH; MODEL; FRAGMENTATION; TEMPERATURE; DERIVATIVES; ELASTICITY; SIMULATION AB A finite strain theory is developed for polycrystalline brittle materials undergoing shock loading. Inelastic deformation arises principally from extension and opening or sliding of microcracks, and depends on pressure as well as deviatoric stress. In the general theory, internal energy depends on a logarithmic measure of finite elastic strain, entropy, and an internal variable associated with fracture. The theory is applied towards planar shock loading of an isotropic sample under possible static pre-stress. An exact analytical solution is derived when inelasticity is idealized as rate independent. The model and solution are applied to describe polycrystalline ceramic titanium diboride. Results provide new insight into experimental shock data, demonstrating importance of elastic nonlinearity and pressure dependent strength. The model describes shock pressure, mean stress, and shear stress in shocked titanium diboride, including the double yield point, with a minimal number of fitting parameters. The analysis predicts an increase in the Hugoniot elastic limit and suppression of inelasticity with increasing compressive pre-stress, in agreement with recent experiments. Published by Elsevier Ltd. C1 US Army Res Lab, RDRL WMP C, Aberdeen Proving Ground, MD 21005 USA. RP Clayton, JD (reprint author), US Army Res Lab, RDRL WMP C, Aberdeen Proving Ground, MD 21005 USA. EM john.d.clayton1.civ@mail.mil RI Clayton, John/C-7760-2009 NR 43 TC 5 Z9 5 U1 1 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X EI 1879-3509 J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD NOV PY 2014 VL 73 BP 56 EP 65 DI 10.1016/j.ijimpeng.2014.06.003 PG 10 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA AO0HS UT WOS:000340990300005 ER PT J AU Meyer, CD Bedair, SS Morgan, BC Arnold, DP AF Meyer, Christopher D. Bedair, Sarah S. Morgan, Brian C. Arnold, David P. TI A Micromachined Wiring Board With Integrated Microinductor for Chip-Scale Power Conversion SO IEEE TRANSACTIONS ON POWER ELECTRONICS LA English DT Article DE DC-DC power converters; integrated circuit packaging; micromachining; thick-film inductors ID DC-DC CONVERTER; AIR-CORE INDUCTORS; SPIRAL INDUCTORS; MICROFABRICATED INDUCTORS; BOOST CONVERTERS; BUCK CONVERTER; DESIGN; EFFICIENCY; TRANSFORMERS; SILICON AB This paper presents a multilayer wiring board that integrates a copper air-core microinductor to enable a highly compact, chip-scale power converter module. The wiring board is wafer-level fabricatedwith three 30-mu m-thick electroplated copper layers and is subsequently detached from the fabrication wafer to yield a board that is only 90 mu m thick for minimum overall module volume. Within this platform, a stacked-spiral air-core microinductor is designed for high-switching-frequency power conversion and yields high inductance density of 128 nH/mm(2) (100 nH/mm(3) by volume, including 600 mu m clearances both above and below the inductor to minimize coupling with external conductors). Although this technology is anticipated to be more appropriate for emerging, experimental converters with switching frequencies > 30 MHz, a proof-of-concept, ultraminiature (9 mm(2) footprint, 0.7 mm thick) power converter module is presented that utilizes the microinductor wiring board in conjunction with a commercially available surface-mount boost regulator (similar to 4 MHz switching frequency). The converter module yielded a maximum output power of 153 mW at 60% efficiency for a volumetric power density of 24 mW/mm(3) based on the physical volume occupied by themodule (13 mW/mm(3) based on the volume needing to be kept clear from external conductors). C1 [Meyer, Christopher D.; Bedair, Sarah S.; Morgan, Brian C.] US Army, Res Lab, Dept Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Arnold, David P.] Univ Florida, Dept Elect & Comp Engn, Gainesville, FL 32611 USA. RP Meyer, CD (reprint author), US Army, Res Lab, Dept Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. EM christopher.d.meyer1.civ@mail.mil; sarah.s.bedair.civ@mail.mil; brian.c.morgan25.civ@mail.mil; darnold@ufl.edu NR 66 TC 5 Z9 5 U1 0 U2 25 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0885-8993 EI 1941-0107 J9 IEEE T POWER ELECTR JI IEEE Trans. Power Electron. PD NOV PY 2014 VL 29 IS 11 BP 6052 EP 6063 DI 10.1109/TPEL.2013.2296507 PG 12 WC Engineering, Electrical & Electronic SC Engineering GA AM1PJ UT WOS:000339619400037 ER PT J AU Blakely, JN Corron, NJ AF Blakely, J. N. Corron, N. J. TI Ambiguity in range-Doppler determination using waveforms of a solvable chaotic oscillator SO SIGNAL PROCESSING LA English DT Article DE Ambiguity function; Chaos; Radar; Nonlinear; Pulse compression; Phase coded waveforms ID COLPITTS OSCILLATOR; RADAR; SIGNALS AB The ambiguity function is derived analytically for waveforms from a chaotic oscillator that has an analytic solution. The chaotic solutions of this oscillator can be expressed as a superposition of basis functions, similar to conventional communication or phase coded radar waveforms. Example waveforms are considered to illustrate the variety of ambiguity functions obtainable from a free running oscillator. The mean and the variance of the ambiguity function for waveforms generated by a free running oscillator are derived to determine typical performance. The mean ambiguity function is shown to have a single, localized peak with low variance indicating that solvable chaos has significant potential as the basis of novel remote sensing technologies. Published by Elsevier B.V. C1 [Blakely, J. N.; Corron, N. J.] US Army, RDMR WSS, Aviat & Missile Res Dev & Engn Ctr, Charles M Bowden Lab, Redstone Arsenal, AL 35898 USA. RP Blakely, JN (reprint author), US Army, RDMR WSS, Aviat & Missile Res Dev & Engn Ctr, Charles M Bowden Lab, Redstone Arsenal, AL 35898 USA. EM jonathan.blakely@us.army.mil; ned.corron@us.army.mil OI Blakely, Jonathan/0000-0002-9772-582X; Corron, Ned/0000-0002-3232-5024 NR 32 TC 3 Z9 3 U1 0 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-1684 EI 1879-2677 J9 SIGNAL PROCESS JI Signal Process. PD NOV PY 2014 VL 104 BP 136 EP 142 DI 10.1016/j.sigpro.2014.03.032 PG 7 WC Engineering, Electrical & Electronic SC Engineering GA AK4KB UT WOS:000338392500013 ER PT J AU Harmata, AJ Ward, CL Zienkiewicz, KJ Wenke, JC Guelcher, SA AF Harmata, Andrew J. Ward, Catherine L. Zienkiewicz, Katarzyna J. Wenke, Joseph C. Guelcher, Scott A. TI Investigating the effects of surface-initiated polymerization of epsilon-caprolactone to bioactive glass particles on the mechanical properties of settable polymer/ceramic composites SO JOURNAL OF MATERIALS RESEARCH LA English DT Article ID CALCIUM-PHOSPHATE CEMENT; BONE-GRAFT SUBSTITUTES; TISSUE ENGINEERING SCAFFOLDS; IN-VITRO BIOCOMPATIBILITY; TIBIAL PLATEAU FRACTURES; BIODEGRADABLE POLYMERS; FIBER-COMPOSITE; TRABECULAR BONE; FOAM SCAFFOLDS; AUGMENTATION AB Injectable bone grafts with strength exceeding that of trabecular bone could improve the clinical management of a number of orthopedic conditions. Ceramic/polymer composites have been investigated as weight-bearing bone grafts, but they are typically weaker than trabecular bone due to poor interfacial bonding. We hypothesized that entrapment of surface-initiated poly (epsilon-caprolactone) (PCL) chains on 45S5 bioactive glass (BG) particles within an in situ-formed polymer network would enhance the mechanical properties of reactive BG/polymer composites. When the surface-initiated PCL molecular weight exceeded the molecular weight between crosslinks of the network, the compressive strength of the composites increased 6- to 10-fold. The torsional strength of the composites exceeded that of human trabecular bone by a factor of two. When injected into femoral condyle defects in rats, the composites supported new bone formation at 8 weeks. The initial bone-like strength of BG/polymer composites and their ability to remodel in vivo highlight their potential for development as injectable grafts for repair of weight-bearing bone defects. C1 [Harmata, Andrew J.; Zienkiewicz, Katarzyna J.; Guelcher, Scott A.] Vanderbilt Univ, Dept Chem & Biomol Engn, Nashville, TN 37235 USA. [Harmata, Andrew J.; Guelcher, Scott A.] Vanderbilt Univ Sch Med, Ctr Bone Biol, Nashville, TN 37232 USA. [Ward, Catherine L.; Wenke, Joseph C.] US Army, Inst Surg Res, Orthopaed Task Area, Ft Sam Houston, TX 78234 USA. [Guelcher, Scott A.] Vanderbilt Univ, Dept Biomed Engn, Nashville, TN 37235 USA. RP Guelcher, SA (reprint author), Vanderbilt Univ, Dept Chem & Biomol Engn, Nashville, TN 37235 USA. EM scott.guelcher@vanderbilt.edu FU National Science Foundation [0847711]; National Institutes of Health through the National Institute of Arthritis and Musculoskeletal and Skin Diseases [AR064304]; Oak Ridge Institute for Science and Education Fellowship - U.S. Army Medical Research and Materiel Command FX This material is based upon work supported by the National Science Foundation under (Grant No. 0847711) (CAREER award to S.A. Guelcher) and the National Institutes of Health through the National Institute of Arthritis and Musculoskeletal and Skin Diseases under Award Number AR064304 (S.A. Guelcher and J. C. Wenke). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. A.J. Harmata acknowledges financial support from an Oak Ridge Institute for Science and Education Fellowship funded by the U.S. Army Medical Research and Materiel Command. NR 47 TC 6 Z9 6 U1 4 U2 15 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0884-2914 EI 2044-5326 J9 J MATER RES JI J. Mater. Res. PD OCT 28 PY 2014 VL 29 IS 20 BP 2398 EP 2407 DI 10.1557/jmr.2014.254 PG 10 WC Materials Science, Multidisciplinary SC Materials Science GA AS8CI UT WOS:000344477500005 PM 25798027 ER PT J AU Dommaraju, K Kijak, G Carlson, JM Larsen, BB Tovanabutra, S Geraghty, DE Deng, W Maust, BS Edlefsen, PT Sanders-Buell, E Ratto-Kim, S deSouza, MS Rerks-Ngarm, S Nitayaphan, S Pitisuttihum, P Kaewkungwal, J O'Connell, RJ Robb, ML Michael, NL Mullins, JI Kim, JH Rolland, M AF Dommaraju, Kalpana Kijak, Gustavo Carlson, Jonathan M. Larsen, Brendan B. Tovanabutra, Sodsai Geraghty, Dan E. Deng, Wenjie Maust, Brandon S. Edlefsen, Paul T. Sanders-Buell, Eric Ratto-Kim, Silvia deSouza, Mark S. Rerks-Ngarm, Supachai Nitayaphan, Sorachai Pitisuttihum, Punnee Kaewkungwal, Jaranit O'Connell, Robert J. Robb, Merlin L. Michael, Nelson L. Mullins, James I. Kim, Jerome H. Rolland, Morgane TI CD8 and CD4 Epitope Predictions in RV144: No Strong Evidence of a T-Cell Driven Sieve Effect in HIV-1 Breakthrough Sequences from Trial Participants SO PLOS ONE LA English DT Article ID VACCINE EFFICACY; PROTEIN; ANTIBODIES; INFECTION; ENVELOPE; REGIONS AB The modest protection afforded by the RV144 vaccine offers an opportunity to evaluate its mechanisms of protection. Differences between HIV-1 breakthrough viruses from vaccine and placebo recipients can be attributed to the RV144 vaccine as this was a randomized and double-blinded trial. CD8 and CD4 T cell epitope repertoires were predicted in HIV-1 proteomes from 110 RV144 participants. Predicted Gag epitope repertoires were smaller in vaccine than in placebo recipients (p = 0.019). After comparing participant-derived epitopes to corresponding epitopes in the RV144 vaccine, the proportion of epitopes that could be matched differed depending on the protein conservation (only 36% of epitopes in Env vs 84-91% in Gag/Pol/Nef for CD8 predicted epitopes) or on vaccine insert subtype (55% against CRF01_AE vs 7% against subtype B). To compare predicted epitopes to the vaccine, we analyzed predicted binding affinity and evolutionary distance measurements. Comparisons between the vaccine and placebo arm did not reveal robust evidence for a T cell driven sieve effect, although some differences were noted in Env-V2 (0.022 <= p-value <= 0.231). The paucity of CD8 T cell responses identified following RV144 vaccination, with no evidence for V2 specificity, considered together both with the association of decreased infection risk in RV 144 participants with V-specific antibody responses and a V2 sieve effect, lead us to hypothesize that this sieve effect was not T cell specific. Overall, our results did not reveal a strong differential impact of vaccine-induced T cell responses among breakthrough infections in RV144 participants. C1 [Dommaraju, Kalpana; Kijak, Gustavo; Tovanabutra, Sodsai; Sanders-Buell, Eric; Ratto-Kim, Silvia; Robb, Merlin L.; Michael, Nelson L.; Kim, Jerome H.; Rolland, Morgane] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Dommaraju, Kalpana; Kijak, Gustavo; Tovanabutra, Sodsai; Sanders-Buell, Eric; Ratto-Kim, Silvia; Robb, Merlin L.; Rolland, Morgane] Henry Jackson Fdn, Bethesda, MD USA. [Carlson, Jonathan M.] Microsoft Res, Los Angeles, CA USA. [Larsen, Brendan B.; Deng, Wenjie; Maust, Brandon S.; Mullins, James I.] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA. [Geraghty, Dan E.; Edlefsen, Paul T.] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USA. [deSouza, Mark S.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Rerks-Ngarm, Supachai] Thai Minist Publ Hlth, Nonthaburi, Thailand. [Nitayaphan, Sorachai] Armed Forces Res Inst Med Sci, Royal Thai Army Component, Bangkok 10400, Thailand. [Pitisuttihum, Punnee; Kaewkungwal, Jaranit] Mahidol Univ, Fac Trop Med, Bangkok, Thailand. RP Rolland, M (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. EM mrolland@hivresearch.org FU U.S. Army Medical Research and Material Command [Y1-AI-2642-12]; National Institutes of Allergy and Infectious Diseases [Y1-AI-2642-12]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense [W81XWH-07-2-0067] FX This work was supported in part by an Interagency Agreement Y1-AI-2642-12 between the U.S. Army Medical Research and Material Command and the National Institutes of Allergy and Infectious Diseases and by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 17 TC 2 Z9 2 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD OCT 28 PY 2014 VL 9 IS 10 AR e111334 DI 10.1371/journal.pone.0111334 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AS0BH UT WOS:000343943100065 PM 25350851 ER PT J AU Jean, A Nyein, MK Zheng, JQ Moore, DF Joannopoulos, JD Radovitzky, R AF Jean, Aurelie Nyein, Michelle K. Zheng, James Q. Moore, David F. Joannopoulos, John D. Radovitzky, Raul TI An animal-to-human scaling law for blast-induced traumatic brain injury risk assessment SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE interspecies scaling; injury risk criteria; transfer function; TBI ID DIFFUSE AXONAL INJURY; VIRTUAL TEST FACILITY; HUMAN HEAD; DYNAMIC-RESPONSE; EXPLOSIVE BLAST; DURATION BLASTS; IMPACT; MODEL; BIOMECHANICS; SIMULATION AB Despite recent efforts to understand blast effects on the human brain, there are still no widely accepted injury criteria for humans. Recent animal studies have resulted in important advances in the understanding of brain injury due to intense dynamic loads. However, the applicability of animal brain injury results to humans remains uncertain. Here, we use advanced computational models to derive a scaling law relating blast wave intensity to the mechanical response of brain tissue across species. Detailed simulations of blast effects on the brain are conducted for different mammals using image-based biofidelic models. The intensity of the stress waves computed for different external blast conditions is compared across species. It is found that mass scaling, which successfully estimates blast tolerance of the thorax, fails to capture the brain mechanical response to blast across mammals. Instead, we show that an appropriate scaling variable must account for the mass of protective tissues relative to the brain, as well as their acoustic impedance. Peak stresses transmitted to the brain tissue by the blast are then shown to be a power function of the scaling parameter for a range of blast conditions relevant to TBI. In particular, it is found that human brain vulnerability to blast is higher than for any other mammalian species, which is in distinct contrast to previously proposed scaling laws based on body or brain mass. An application of the scaling law to recent experiments on rabbits furnishes the first physics-based injury estimate for blast-induced TBI in humans. C1 [Jean, Aurelie; Nyein, Michelle K.; Moore, David F.; Joannopoulos, John D.; Radovitzky, Raul] MIT, Inst Soldier Nanotechnol, Cambridge, MA 02139 USA. [Jean, Aurelie; Nyein, Michelle K.; Radovitzky, Raul] MIT, Dept Aeronaut & Astronaut, Cambridge, MA 02139 USA. [Joannopoulos, John D.] MIT, Dept Phys, Cambridge, MA 02139 USA. [Zheng, James Q.] US Army, Program Execut Off Soldier, Ft Belvoir, VA 22060 USA. RP Jean, A (reprint author), MIT, Inst Soldier Nanotechnol, Cambridge, MA 02139 USA. EM ajean@mit.edu; joannop@mit.edu RI Radovitzky, Raul/A-5353-2009 OI Radovitzky, Raul/0000-0001-6339-2708 FU US Army through the Institute for Soldier Nanotechnologies [DAAD-19-02-D-0002] FX This work was supported by the US Army through the Institute for Soldier Nanotechnologies under Contract DAAD-19-02-D-0002. NR 55 TC 6 Z9 6 U1 2 U2 9 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD OCT 28 PY 2014 VL 111 IS 43 BP 15310 EP 15315 DI 10.1073/pnas.1415743111 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AR6ZL UT WOS:000343729500029 PM 25267617 ER PT J AU Schwenk, R Debot, M Porter, M Nikki, J Rein, L Spaccapelo, R Crisanti, A Wightman, PD Ockenhouse, CF Dutta, S AF Schwenk, Robert Debot, Margot Porter, Michael Nikki, Jennifer Rein, Lisa Spaccapelo, Roberta Crisanti, Andrea Wightman, Paul D. Ockenhouse, Christian F. Dutta, Sheetij TI IgG2 Antibodies against a Clinical Grade Plasmodium falciparum CSP Vaccine Antigen Associate with Protection against Transgenic Sporozoite Challenge in Mice SO PLOS ONE LA English DT Article ID T-CELL RESPONSES; MALARIA-NAIVE ADULTS; RECEPTOR 4 AGONIST; PHASE 2A TRIAL; CIRCUMSPOROZOITE PROTEIN; ESCHERICHIA-COLI; DENDRITIC CELLS; SIGNALING PATHWAY; INFLUENZA VACCINE; TLR SYNERGY AB The availability of a highly purified and well characterized circumsporozoite protein (CSP) is essential to improve upon the partial success of recombinant CSP-based malaria vaccine candidates. Soluble, near full-length, Plasmodium falciparum CSP vaccine antigen (CS/D) was produced in E. coli under bio-production conditions that comply with current Good Manufacturing Practices (cGMP). A mouse immunogenicity study was conducted using a stable oil-in-water emulsion (SE) of CS/D in combination with the Toll-Like Receptor 4 (TLR4) agonist Glucopyranosyl Lipid A (GLA/SE), or one of two TLR7/8 agonists: R848 (un-conjugated) or 3M-051 (covalently conjugated). Compared to Alum and SE, GLA/SE induced higher CS/D specific antibody response in Balb/c mice. Subclass analysis showed higher IgG2:IgG1 ratio of GLA/SE induced antibodies as compared to Alum and SE. TLR synergy was not observed when soluble R848 was mixed with GLA/SE. Antibody response of 3M051 formulations in Balb/c was similar to GLA/SE, except for the higher IgG2: IgG1 ratio and a trend towards higher T cell responses in 3M051 containing groups. However, no synergistic enhancement of antibody and T cell response was evident when 3M051 conjugate was mixed with GLA/SE. In C57Bl/6 mice, CS/D adjuvanted with 3M051/SE or GLA/SE induced higher CSP repeat specific titers compared to SE. While, 3M051 induced antibodies had high IgG2c:IgG1 ratio, GLA/SE promoted high levels of both IgG1 and IgG2c. GLA/SE also induced more potent T-cell responses compared to SE in two independent C57/BL6 vaccination studies, suggesting a balanced and productive T-H1/T-H2 response. GLA and 3M-051 similarly enhanced the protective efficacy of CS/D against challenge with a transgenic P. berghei parasite and most importantly, high levels of cytophilic IgG2 antibodies were associated with protection in this model. Our data indicated that the cGMP-grade, soluble CS/D antigen combined with the TLR4-containing adjuvant GLA/SE warrants further evaluation for protective responses in humans. C1 [Schwenk, Robert; Debot, Margot; Porter, Michael; Nikki, Jennifer; Rein, Lisa; Ockenhouse, Christian F.; Dutta, Sheetij] Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD 20910 USA. [Wightman, Paul D.] 3M Drug Delivery Syst, St Paul, MN USA. [Spaccapelo, Roberta] Univ Perugia, Dept Expt Med, I-06100 Perugia, Italy. [Crisanti, Andrea] Univ London Imperial Coll Sci Technol & Med, London, England. RP Dutta, S (reprint author), Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD 20910 USA. EM Sheetij.dutta.civ@mail.mil FU US Army; United States Agency for International Development Malaria Vaccine Program FX Funding for this work was provided by the US Army and the United States Agency for International Development Malaria Vaccine Program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 50 TC 6 Z9 6 U1 1 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD OCT 24 PY 2014 VL 9 IS 10 AR e111020 DI 10.1371/journal.pone.0111020 PG 16 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AS0BL UT WOS:000343943500077 PM 25343487 ER PT J AU Nepovimova, E Uliassi, E Korabecny, J Pena-Altamira, LE Samez, S Pesaresi, A Garcia, GE Bartolini, M Andrisano, V Bergamini, C Fato, R Lamba, D Roberti, M Kuca, K Monti, B Bolognesi, ML AF Nepovimova, Eugenie Uliassi, Elisa Korabecny, Jan Pena-Altamira, Luis Emiliano Samez, Sarah Pesaresi, Alessandro Garcia, Gregory E. Bartolini, Manuela Andrisano, Vincenza Bergamini, Christian Fato, Romana Lamba, Doriano Roberti, Marinella Kuca, Kamil Monti, Barbara Bolognesi, Maria Laura TI Multitarget Drug Design Strategy: Quinone Tacrine Hybrids Designed To Block Amyloid-beta Aggregation and To Exert Anticholinesterase and Antioxidant Effects SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID TARGET-DIRECTED LIGANDS; ALZHEIMERS-DISEASE; ACETYLCHOLINESTERASE INHIBITORS; NEURODEGENERATIVE DISEASES; NEUROPROTECTIVE AGENTS; MULTIFUNCTIONAL AGENTS; CRYSTAL-STRUCTURES; OXIDATIVE STRESS; CROSS-TALK; VITAMIN-K AB We report the identification of multitarget anti-Alzheimer compounds designed by combining a naphthoquinone function and a tacrine fragment. In vitro, 15 compounds displayed excellent acetylcholinesterase (AChE) inhibitory potencies and interesting capabilities to block amyloid-beta (A beta) aggregation. The X-ray analysis of one of those compounds in complex with AChE allowed rationalizing the outstanding activity data (IC50 = 0.72 nM). Two of the compounds showed negligible toxicity in immortalized mouse cortical neurons Neuro2A and primary rat cerebellar granule neurons. However, only one of them was less hepatotoxic than tacrine in HepG2 cells. In T67 cells, both compounds showed antioxidant activity, following NQO1 induction. Furthermore, in Neuro2A, they were able to completely revert the decrease in viability induced by A beta. Importantly, they crossed the blood-brain barrier, as demonstrated in ex vivo experiments with rats. When ex vivo results were combined with in vitro studies, these two compounds emerged to be promising multitarget lead candidates worthy of further pursuit. C1 [Nepovimova, Eugenie; Uliassi, Elisa; Pena-Altamira, Luis Emiliano; Bartolini, Manuela; Bergamini, Christian; Fato, Romana; Roberti, Marinella; Monti, Barbara; Bolognesi, Maria Laura] Alma Mater Studiorum Univ Bologna, Dept Pharm & Biotechnol, I-40126 Bologna, Italy. [Nepovimova, Eugenie; Korabecny, Jan] Univ Def, Dept Toxicol, Dept Publ Hlth, Ctr Adv Studies,Fac Mil Hlth Sci, Hradec Kralove 50001, Czech Republic. [Nepovimova, Eugenie; Korabecny, Jan; Kuca, Kamil] Univ Hosp Hradec Kralove, Biomed Res Ctr, Hradec Kralove 50005, Czech Republic. [Nepovimova, Eugenie] Charles Univ Prague, Dept Pharmaceut Chem & Drug Control, Fac Pharm Hradec Kralove, Hradec Kralove 50005, Czech Republic. [Samez, Sarah; Pesaresi, Alessandro; Lamba, Doriano] CNR, Ist Crystallog, I-34149 Trieste, Italy. [Samez, Sarah] Univ Trieste, Dipartimento Sci Chim & Farmaceut, I-34127 Trieste, Italy. [Garcia, Gregory E.] US Army, Div Res, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. [Andrisano, Vincenza] Alma Mater Studiorum Univ Bologna, Dept Life Qual Studies, I-47921 Rimini, Italy. RP Bolognesi, ML (reprint author), Alma Mater Studiorum Univ Bologna, Dept Pharm & Biotechnol, Via Belmeloro 6, I-40126 Bologna, Italy. EM marialaura.bolognesi@unibo.it RI Lamba, Doriano/B-2961-2011; OI Lamba, Doriano/0000-0001-6859-7868; ANDRISANO, VINCENZA/0000-0003-4396-1904 FU University of Bologna; Grant Agency of the Czech Republic [P303/11/1907]; MH CZ-DRO (University Hospital Hradec Kralove) [00179906] FX This work was supported by the University of Bologna, Grant Agency of the Czech Republic (No. P303/11/1907), and MH CZ-DRO (University Hospital Hradec Kralove, No. 00179906). We are grateful to the ELETTRA XRD1 beamline staff for their assistance during the data collection. Thanks are also due to UniRimini S.p.A. and CIRI (PORFESR project). NR 75 TC 41 Z9 41 U1 5 U2 61 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 EI 1520-4804 J9 J MED CHEM JI J. Med. Chem. PD OCT 23 PY 2014 VL 57 IS 20 BP 8576 EP 8589 DI 10.1021/jm5010804 PG 14 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA AR7DT UT WOS:000343740700027 PM 25259726 ER PT J AU Horm, SV Mardy, S Rith, S Ly, S Heng, S Vong, S Kitsutani, P Ieng, V Tarantola, A Ly, S Sar, B Chea, N Sokhal, B Barr, I Kelso, A Horwood, PF Timmermans, A Hurt, A Lon, C Saunders, D Ung, SA Asgari, N Roces, MC Touch, S Komadina, N Buchy, P AF Horm, Srey Viseth Mardy, Sek Rith, Sareth Ly, Sovann Heng, Seng Vong, Sirenda Kitsutani, Paul Ieng, Vannra Tarantola, Arnaud Ly, Sowath Sar, Borann Chea, Nora Sokhal, Buth Barr, Ian Kelso, Anne Horwood, Paul F. Timmermans, Ans Hurt, Aeron Lon, Chanthap Saunders, David Ung, Sam An Asgari, Nima Roces, Maria Concepcion Touch, Sok Komadina, Naomi Buchy, Philippe TI Epidemiological and Virological Characteristics of Influenza Viruses Circulating in Cambodia from 2009 to 2011 SO PLOS ONE LA English DT Article ID ADAMANTANE RESISTANCE; SEASONAL INFLUENZA; A VIRUSES; ANTIVIRAL RESISTANCE; UNITED-STATES; SURVEILLANCE; REASSORTMENT; MORTALITY; EVOLUTION; TAIWAN AB Background: The Cambodian National Influenza Center (NIC) monitored and characterized circulating influenza strains from 2009 to 2011. Methodology/Principal Findings: Sentinel and study sites collected nasopharyngeal specimens for diagnostic detection, virus isolation, antigenic characterization, sequencing and antiviral susceptibility analysis from patients who fulfilled case definitions for influenza-like illness, acute lower respiratory infections and event-based surveillance. Each year in Cambodia, influenza viruses were detected mainly from June to November, during the rainy season. Antigenic analysis show that A/H1N1pdm09 isolates belonged to the A/California/7/2009-like group. Circulating A/H3N2 strains were A/Brisbane/10/2007-like in 2009 before drifting to A/Perth/16/2009-like in 2010 and 2011. The Cambodian influenza B isolates from 2009 to 2011 all belonged to the B/Victoria lineage represented by the vaccine strains B/Brisbane/60/2008 and B/Malaysia/2506/2004. Sequences of the M2 gene obtained from representative 2009-2011 A/H3N2 and A/H1N1pdm09 strains all contained the S31N mutation associated with adamantanes resistance except for one A/H1N1pdm09 strain isolated in 2011 that lacked this mutation. No reduction in the susceptibility to neuraminidase inhibitors was observed among the influenza viruses circulating from 2009 to 2011. Phylogenetic analysis revealed that A/H3N2 strains clustered each year to a distinct group while most A/H1N1pdm09 isolates belonged to the S203T clade. Conclusions/Significance: In Cambodia, from 2009 to 2011, influenza activity occurred throughout the year with peak seasonality during the rainy season from June to November. Seasonal influenza epidemics were due to multiple genetically distinct viruses, even though all of the isolates were antigenically similar to the reference vaccine strains. The drug susceptibility profile of Cambodian influenza strains revealed that neuraminidase inhibitors would be the drug of choice for influenza treatment and chemoprophylaxis in Cambodia, as adamantanes are no longer expected to be effective. C1 [Horm, Srey Viseth; Mardy, Sek; Rith, Sareth; Vong, Sirenda; Tarantola, Arnaud; Ly, Sowath; Horwood, Paul F.; Buchy, Philippe] Reseau Int Inst Pasteur, Inst Pasteur Cambodge, Phnom Penh, Cambodia. [Mardy, Sek; Ieng, Vannra; Asgari, Nima; Roces, Maria Concepcion] WHO, Phnom Penh, Cambodia. [Ly, Sovann; Heng, Seng; Touch, Sok] Minist Hlth, Dept Communicable Dis Control, Phnom Penh, Cambodia. [Kitsutani, Paul] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Influenza Div, Atlanta, GA USA. [Sar, Borann; Chea, Nora] Ctr Dis Control & Prevent, Cambodia Off, Phnom Penh, Cambodia. [Sokhal, Buth; Ung, Sam An] Natl Inst Publ Hlth, Phnom Penh, Cambodia. [Barr, Ian; Kelso, Anne; Hurt, Aeron; Komadina, Naomi] WHO Collaborating Ctr Reference & Res Influenza, Melbourne, Vic, Australia. [Timmermans, Ans; Lon, Chanthap; Saunders, David] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Buchy, P (reprint author), Reseau Int Inst Pasteur, Inst Pasteur Cambodge, Phnom Penh, Cambodia. EM buchyphilippe@hotmail.com OI Barr, Ian/0000-0002-7351-418X; Hurt, Aeron/0000-0003-1826-4314; Tarantola, Arnaud/0000-0002-6946-7958 FU World Health Organization office in Cambodia; French Agency for Development (SISEA project); Office of the Assistant Secretary for Preparedness and Response within the U.S. Department of Health and Human Services FX The study was funded by the World Health Organization office in Cambodia, the French Agency for Development (SISEA project) and by the Office of the Assistant Secretary for Preparedness and Response within the U.S. Department of Health and Human Services. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 58 TC 3 Z9 3 U1 0 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD OCT 23 PY 2014 VL 9 IS 10 AR e110713 DI 10.1371/journal.pone.0110713 PG 14 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AR5ZY UT WOS:000343662800050 PM 25340711 ER PT J AU Adlakha, I Bhatia, MA Tschopp, MA Solanki, KN AF Adlakha, I. Bhatia, M. A. Tschopp, M. A. Solanki, K. N. TI Atomic scale investigation of grain boundary structure role on intergranular deformation in aluminium SO PHILOSOPHICAL MAGAZINE LA English DT Article DE fracture; dislocation; grain boundary; directional anisotropy ID MOLECULAR-DYNAMICS SIMULATION; CRACK-TIP; DISLOCATION NUCLEATION; DIRECTIONAL DEPENDENCE; COPPER/SAPPHIRE BICRYSTAL; FRACTURE; METALS; GROWTH; AL; EMBRITTLEMENT AB The role that grain boundary (GB) structure plays on the directional asymmetry of an intergranular crack (i.e. cleavage behaviour is favoured along one direction, while ductile behaviour along the other direction of the interface) was investigated using atomistic simulations for aluminium < 110 > symmetric tilt GBs. Middle-tension (M(T)) and Mode-I crack propagation specimens were used to evaluate the predictive capability of the Rice criterion. The stress-strain response of the GBs for the M(T) specimens highlighted the importance of the GB structure. The observed crack tip behaviour for certain GBs (sigma 9 (221), sigma 11 (332) and sigma 33 (441)) with the M(T) specimen displayed an absence of directional asymmetry which is in disagreement with the Rice criterion. Moreover, in these GBs with the M(T) specimen, the dislocation emission from a GB source at a finite distance ahead of the crack tip was observed rather than from the crack tip, as suggested by the Rice criterion. In an attempt to understand discrepancy between the theoretical predictions and atomistic observations, the effect of boundary conditions (M(T), Mode-I and the edge crack) on the crack tip events was examined and it was concluded that the incipient plastic events observed were strongly influenced by the boundary conditions (i.e. activation of dislocation sources along the GB, in contrast to dislocation nucleation directly from the crack tip). In summary, these findings provide new insights into crack growth behaviour along GB interfaces and provide a physical basis for examining the role of the GB character on incipient event ahead of a crack tip and interface properties, as an input to higher scale models. C1 [Adlakha, I.; Bhatia, M. A.; Solanki, K. N.] Arizona State Univ, Sch Engn Matter Transport & Energy, Tempe, AZ 85287 USA. [Tschopp, M. A.] US Army Res Lab, Aberdeen, MD 21005 USA. RP Solanki, KN (reprint author), Arizona State Univ, Sch Engn Matter Transport & Energy, Tempe, AZ 85287 USA. EM kiran.solanki@asu.edu RI Solanki, Kiran/E-8337-2010; OI Adlakha, Ilaksh/0000-0002-2028-3357; Tschopp, Mark/0000-0001-8471-5035 FU Office of Naval Research [N000141110793] FX The authors would like to recognize Dr W Mullins and Dr AK Vasudevan from the Office of Naval Research for providing insights and valuable suggestions. This material is based upon work supported by the Office of Naval Research under contract No. N000141110793. We would also like to acknowledge the Fulton High Performance Computing at Arizona State University and the anonymous reviewers for their helpful comments. NR 56 TC 5 Z9 5 U1 6 U2 40 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1478-6435 EI 1478-6443 J9 PHILOS MAG JI Philos. Mag. PD OCT 23 PY 2014 VL 94 IS 30 BP 3445 EP 3466 DI 10.1080/14786435.2014.961585 PG 22 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering; Physics, Applied; Physics, Condensed Matter SC Materials Science; Metallurgy & Metallurgical Engineering; Physics GA AQ5KK UT WOS:000342847100004 ER PT J AU Hoge, CW Castro, CA AF Hoge, Charles W. Castro, Carl A. TI Treatment of Generalized War-Related Health Concerns Placing TBI and PTSD in Context SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Editorial Material ID TRAUMATIC BRAIN-INJURY; POSTTRAUMATIC-STRESS-DISORDER; NATIONAL-GUARD; OUTCOMES; COMBAT; ASSOCIATION; RISK C1 [Hoge, Charles W.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Castro, Carl A.] Univ So Calif, Sch Social Work, Los Angeles, CA 90089 USA. RP Hoge, CW (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. EM charles.hoge@us.army.mil OI Nievergelt, Caroline/0000-0001-5766-8923 NR 9 TC 11 Z9 11 U1 2 U2 9 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 0098-7484 EI 1538-3598 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD OCT 22 PY 2014 VL 312 IS 16 BP 1685 EP 1686 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA AR0YF UT WOS:000343301400026 PM 25335151 ER PT J AU Brunye, TT Holmes, A Cantelon, J Eddy, MD Gardony, AL Mahoney, CR Taylor, HA AF Brunye, Tad T. Holmes, Amanda Cantelon, Julie Eddy, Marianna D. Gardony, Aaron L. Mahoney, Caroline R. Taylor, Holly A. TI Direct current brain stimulation enhances navigation efficiency in individuals with low spatial sense of direction SO NEUROREPORT LA English DT Article DE direct current stimulation; individual differences; navigation; spatial memory; temporal cortex ID ELECTRICAL-STIMULATION; MEMORY; ATTENTION; ABILITY; CORTEX; SHIFTS AB The aim of this study was to evaluate the influence of right versus left temporal transcranial direct current stimulation (tDCS) on navigation efficiency and spatial memory in individuals with low versus high spatial skills. A mixed design administered low (0.5mA) versus high (2.0mA) anodal tDCS (within-participants) over the right or the left temporal lobe (between-participants), centered at electrode site T8 (right) or T7 (left). During stimulation, participants navigated virtual environments in search of specified landmarks, and data were logged in terms of current position and heading over time. Following stimulation, participants completed pointing and map-drawing spatial memory tests. Individual differences in sense of direction reliably and inversely predicted navigation advantages in the 2.0 versus 0.5mA right hemisphere stimulation condition (R-2=0.45, P<0.01); in other words, individuals with lower sense of direction showed increased navigation efficiency in the 2.0 versus 0.5mA condition. Spatial memory tests also showed the development of relatively comprehensive spatial memories: bidimensional regression indicated lower distortion in sketch maps drawn following 2.0 versus 0.5mA right temporal lobe stimulation (F=8.7, P<0.05). Data provide the first demonstration that right temporal anodal tDCS may hold potential for enhancing navigation efficiency in otherwise poor navigators. Data support neuroimaging studies showing the engagement of right temporal brain regions in developing and applying spatial memories during complex navigation tasks, and uniquely suggest that continuing research may find value in optimizing stimulation parameters (intensity, focality) as a function of individual differences. C1 [Brunye, Tad T.; Holmes, Amanda; Cantelon, Julie; Eddy, Marianna D.; Gardony, Aaron L.; Mahoney, Caroline R.] US Army, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. [Brunye, Tad T.; Holmes, Amanda; Cantelon, Julie; Eddy, Marianna D.; Gardony, Aaron L.; Mahoney, Caroline R.; Taylor, Holly A.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA. RP Brunye, TT (reprint author), US Army, Natick Soldier Res Dev & Engn Ctr, RDNS SEW THC, Bldg 4,Room 126,15 Kansas St, Natick, MA 01760 USA. EM tbruny01@tufts.edu NR 25 TC 6 Z9 6 U1 2 U2 11 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0959-4965 EI 1473-558X J9 NEUROREPORT JI Neuroreport PD OCT 22 PY 2014 VL 25 IS 15 BP 1175 EP 1179 DI 10.1097/WNR.0000000000000214 PG 5 WC Neurosciences SC Neurosciences & Neurology GA AP8PK UT WOS:000342340700001 PM 25144391 ER PT J AU Peng, Y Maxwell, AS Barker, ND Laird, JG Kennedy, AJ Wang, N Zhang, CY Gong, P AF Peng, Yan Maxwell, Andrew S. Barker, Natalie D. Laird, Jennifer G. Kennedy, Alan J. Wang, Nan Zhang, Chaoyang Gong, Ping TI SeqAssist: a novel toolkit for preliminary analysis of next-generation sequencing data SO BMC BIOINFORMATICS LA English DT Article; Proceedings Paper CT 11th Annual Conference of the MidSouth-Computational-Biology-and-Bioinformatics-Society (MCBIOS) CY MAR 06-08, 2014 CL Oklahoma State Univ, Stillwater, OH SP MidSouth Computat Biol & Bioinformat Soc HO Oklahoma State Univ ID BURROWS-WHEELER TRANSFORM; RNA-SEQ; GENETIC-VARIATION; GENOME SEQUENCE; READ ALIGNMENT; 10K AB Background: While next-generation sequencing (NGS) technologies are rapidly advancing, an area that lags behind is the development of efficient and user-friendly tools for preliminary analysis of massive NGS data. As an effort to fill this gap to keep up with the fast pace of technological advancement and to accelerate data-to-results turnaround, we developed a novel software package named SeqAssist ("Sequencing Assistant" or SA). Results: SeqAssist takes NGS-generated FASTQ files as the input, employs the BWA-MEM aligner for sequence alignment, and aims to provide a quick overview and basic statistics of NGS data. It consists of three separate workflows: (1) the SA_RunStats workflow generates basic statistics about an NGS dataset, including numbers of raw, cleaned, redundant and unique reads, redundancy rate, and a list of unique sequences with length and read count; (2) the SA_Run2Ref workflow estimates the breadth, depth and evenness of genome-wide coverage of the NGS dataset at a nucleotide resolution; and (3) the SA_Run2Run workflow compares two NGS datasets to determine the redundancy (overlapping rate) between the two NGS runs. Statistics produced by SeqAssist or derived from SeqAssist output files are designed to inform the user: whether, what percentage, how many times and how evenly a genomic locus (i.e., gene, scaffold, chromosome or genome) is covered by sequencing reads, how redundant the sequencing reads are in a single run or between two runs. These statistics can guide the user in evaluating the quality of a DNA library prepared for RNA-Seq or genome (re-)sequencing and in deciding the number of sequencing runs required for the library. We have tested SeqAssist using a synthetic dataset and demonstrated its main features using multiple NGS datasets generated from genome re-sequencing experiments. Conclusions: SeqAssist is a useful and informative tool that can serve as a valuable "assistant" to a broad range of investigators who conduct genome re-sequencing, RNA-Seq, or de novo genome sequencing and assembly experiments. C1 [Peng, Yan; Maxwell, Andrew S.; Wang, Nan; Zhang, Chaoyang] Univ So Mississippi, Sch Comp, Hattiesburg, MS 39406 USA. [Barker, Natalie D.; Gong, Ping] Badger Tech Serv LLC, San Antonio, TX 78216 USA. [Laird, Jennifer G.; Kennedy, Alan J.] US Army, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Zhang, CY (reprint author), Univ So Mississippi, Sch Comp, Hattiesburg, MS 39406 USA. EM Chaoyang.Zhang@usm.edu; Ping.Gong@usace.army.mil NR 23 TC 3 Z9 3 U1 1 U2 10 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2105 J9 BMC BIOINFORMATICS JI BMC Bioinformatics PD OCT 21 PY 2014 VL 15 SU 11 AR S10 DI 10.1186/1471-2105-15-S11-S10 PG 11 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Mathematical & Computational Biology GA AU6AN UT WOS:000345684600011 PM 25349885 ER PT J AU Ohrt, C Li, QG Obaldia, N Im-Erbsin, R Xie, LS Berman, J AF Ohrt, Colin Li, Qigui Obaldia, Nicanor Im-Erbsin, Rawiwan Xie, Lisa Berman, Jonathan TI Efficacy of intravenous methylene blue, intravenous artesunate, and their combination in preclinical models of malaria SO MALARIA JOURNAL LA English DT Article DE Methylene blue; Artesunate; Combinations; Malaria; Rat; Aotus; Rhesus ID UNCOMPLICATED FALCIPARUM-MALARIA; ARTEMISININ RESISTANCE; PLASMODIUM-FALCIPARUM; CEREBRAL MALARIA; RANDOMIZED-TRIAL; BURKINA-FASO; OWL MONKEY; IN-VIVO; AOTUS; ENCEPHALOPATHY AB Background: Intravenous artesunate (IV AS) is the present treatment of choice for severe malaria, but development of artemisinin resistance indicates that a further agent will be needed. Methylene blue (MB) is an approved human agent for IV and oral use, and is already being investigated for oral treatment of uncomplicated malaria. To initiate investigation of IV MB for severe malaria, the efficacy of IV MB was compared to IV AS and to their combination in rat and non-human primate malaria models. Methods: IV MB was compared to IV AS and to their combination in the Plasmodium berghei-infected rat, a self-curing model; the Plasmodium falciparum-infected Aotus monkey, a fatal model; and the Plasmodium cynomolgi-infected rhesus monkey, a fatal model. Key endpoints were clearance of all parasites from the blood and cure (clearance without recrudescence). Results: In rats, the minimal dose of individual drugs and their combination that cleared parasites from all animals was 20 mg IV MB/kg/day, 60 mg IV AS/kg/day and 10 mg IV MB/kg/day plus 30 mg IV AS/kg/day. In Aotus, 8 mg IV MB/kg/day and 8 mg IV AS/kg/day each cured two of three monkeys by one day after therapy, and the third monkey in each group was cured two days later. The combination of both drugs did not result in superior efficacy. In rhesus, 8 mg IV MB/kg/day and 8 mg IV AS/kg/day performed comparably: parasite clearance occurred by day 3 of therapy, although only one of four animals in each dose group cured. Eight mg/kg/day of both drugs in combination was 100% successful: all four of four animals cured. Conclusions: In each of the three animal models, the efficacy of IV MB was approximately equal to that of standard of care IV AS. In the rat and rhesus models, the combination was more effective than either single agent. This preclinical data suggests that IV MB, alone or in combination with IV AS, is effective against Plasmodium spp. and can be evaluated in severe malaria models. C1 [Ohrt, Colin; Li, Qigui; Xie, Lisa; Berman, Jonathan] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Obaldia, Nicanor] Trop Med Res Gorgas Mem Inst, Ctr Evaluat Antimalarial Drugs & Vaccines, Panama City, Panama. [Im-Erbsin, Rawiwan] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Berman, J (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. EM jbe9320457@aol.com RI Obaldia, Nicanor/O-8460-2015; OI Obaldia, Nicanor/0000-0002-3711-9449 NR 30 TC 1 Z9 1 U1 0 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD OCT 21 PY 2014 VL 13 AR 415 DI 10.1186/1475-2875-13-415 PG 8 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AU6LC UT WOS:000345713600001 PM 25336091 ER PT J AU Crow, BS Pantazides, BG Quinones-Gonzalez, J Garton, JW Carter, MD Perez, JW Watson, CM Tomcik, DJ Crenshaw, MD Brewer, BN Riches, JR Stubbs, SJ Read, RW Evans, RA Thomas, JD Blake, TA Johnson, RC AF Crow, Brian S. Pantazides, Brooke G. Quinones-Gonzalez, Jennifer Garton, Joshua W. Carter, Melissa D. Perez, Jonas W. Watson, Caroline M. Tomcik, Dennis J. Crenshaw, Michael D. Brewer, Bobby N. Riches, James R. Stubbs, Sarah J. Read, Robert W. Evans, Ronald A. Thomas, Jerry D. Blake, Thomas A. Johnson, Rudolph C. TI Simultaneous Measurement of Tabun, Sarin, Soman, Cyclosarin, VR, VX, and VM Adducts to Tyrosine in Blood Products by Isotope Dilution UHPLC-MS/MS SO ANALYTICAL CHEMISTRY LA English DT Article ID TANDEM MASS-SPECTROMETRY; ORGANOPHOSPHORUS NERVE AGENTS; INTERACTION LIQUID-CHROMATOGRAPHY; HUMAN SERUM; ACETYLCHOLINESTERASE ACTIVITY; HUMAN BUTYRYLCHOLINESTERASE; BIOLOGICAL MARKERS; KINETIC-ANALYSIS; SULFUR MUSTARD; HUMAN ALBUMIN AB This work describes a new specific, sensitive, and rapid stable isotope dilution method for the simultaneous detection of the organophosphorus nerve agents (OPNAs) tabun (GA), sarin (GB), soman (GD), cyclosarin (GF), VR, VX, and VM adducts to tyrosine (Tyr). Serum, plasma, and lysed whole blood samples (50 mu L) were prepared by protein precipitation followed by digestion with Pronase. Specific Tyr adducts were isolated from the digest by a single solid phase extraction (SPE) step, and the analytes were separated by reversed-phase ultra high performance liquid chromatography (UHPLC) gradient elution in less than 2 min. Detection was performed on a triple quadrupole tandem mass spectrometer using time-triggered selected reaction monitoring (SRM) in positive electrospray ionization (ESI) mode. The calibration range was characterized from 0.100-50.0 ng/mL for GB- and VR-Tyr and 0.250-50.0 ng/mL for GA-, GD-, GF-, and VX/VM-Tyr (R-2 >= 0.995). Inter- and intra-assay precision had coefficients of variation of <= 17 and <= 10%, respectively, and the measured concentration accuracies of spiked samples were within 15% of the targeted value for multiple spiking levels. The limit of detection was calculated to be 0.097, 0.027, 0.018, 0.074, 0.023, and 0.083 ng/mL for GA-, GB-, GD-, GF-, VR-, and VX/VM-Tyr, respectively. A convenience set of 96 serum samples with no known nerve agent exposure was screened and revealed no baseline values or potential interferences. This method provides a simple and highly specific diagnostic tool that may extend the time postevent that a confirmation of nerve agent exposure can be made with confidence. C1 [Crow, Brian S.; Pantazides, Brooke G.; Carter, Melissa D.; Thomas, Jerry D.; Blake, Thomas A.; Johnson, Rudolph C.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. [Quinones-Gonzalez, Jennifer; Garton, Joshua W.; Watson, Caroline M.] Ctr Dis Control & Prevent, Oak Ridge Inst Sci & Educ, Atlanta, GA 30341 USA. [Perez, Jonas W.] Battelle Mem Inst, Atlanta, GA 30329 USA. [Tomcik, Dennis J.; Crenshaw, Michael D.; Brewer, Bobby N.] Battelle Mem Inst, Columbus, OH 43201 USA. [Riches, James R.; Stubbs, Sarah J.; Read, Robert W.] Def Sci & Technol Lab, Salisbury SP4 0JQ, Wilts, England. [Evans, Ronald A.] US Army Edgewood Chem Biol Ctr, Analyt Toxicol Branch, R&T Directorate, Aberdeen Proving Ground, MD 21010 USA. RP Crow, BS (reprint author), Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. EM jgz8@cdc.gov OI Garton, Joshua/0000-0002-4549-1224; Blake, Thomas/0000-0001-8536-9998 FU Centers for Disease Control and Prevention; Defense Threat and Reduction Agency [11-005-12430]; Oak Ridge Institute for Science and Education FX This work was supported by the Centers for Disease Control and Prevention, the Defense Threat and Reduction Agency (11-005-12430), and the Oak Ridge Institute for Science and Education. The authors would like to thank Ms. Chariety Sapp of CDC's Incident Response Laboratory (IRL) for dispensing convenience set samples prior to analysis. The findings and conclusions in this article are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. Use of trade names is for identification only and does not imply endorsement by the Centers for Disease Control and Prevention, the Public Health Service, or the U.S. Department of Health and Human Services. NR 41 TC 8 Z9 8 U1 8 U2 39 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 EI 1520-6882 J9 ANAL CHEM JI Anal. Chem. PD OCT 21 PY 2014 VL 86 IS 20 BP 10397 EP 10405 DI 10.1021/ac502886c PG 9 WC Chemistry, Analytical SC Chemistry GA AR5QY UT WOS:000343639800056 PM 25286390 ER PT J AU Gottfried, JL AF Gottfried, Jennifer L. TI Influence of exothermic chemical reactions on laser-induced shock waves SO PHYSICAL CHEMISTRY CHEMICAL PHYSICS LA English DT Article ID INDUCED BREAKDOWN SPECTROSCOPY; INDUCED PLASMA; ENERGETIC POLYMERS; EXPANSION DYNAMICS; PLUME PROPAGATION; EXPLOSIVE RDX; FUSED-SILICA; BLAST THEORY; ABLATION; GAS AB Differences in the excitation of non-energetic and energetic residues with a 900 mJ, 6 ns laser pulse (1064 nm) have been investigated. Emission from the laser-induced plasma of energetic materials (e.g. triaminotrinitrobenzene [TATB], cyclotrimethylene trinitramine [RDX], and hexanitrohexaazaisowurtzitane (CL-20]) is significantly reduced compared to non-energetic materials (e.g. sugar, melamine, and L-glutamine). Expansion of the resulting laser-induced shock wave into the air above the sample surface was imaged on a microsecond timescale with a high-speed camera recording multiple frames from each laser shot; the excitation of energetic materials produces larger heat-affected zones in the surrounding atmosphere (facilitating deflagration of particles ejected from the sample surface), results in the formation of additional shock fronts, and generates faster external shock front velocities (>750 m s(-1)) compared to non-energetic materials (550-600 m s(-1)). Non-explosive materials that undergo exothermic chemical reactions in air at high temperatures such as ammonium nitrate and magnesium sulfate produce shock velocities Which exceed those of the inert materials but are less than those generated by the exothermic reactions of explosive materials (650-700 m s(-1)). The most powerful explosives produced the highest shock velocities. A comparison to several existing shock models demonstrated that no single model describes the shock propagation for both non-energetic and energetic materials. The influence of the exothermic chemical reactions initiated by the pulsed laser on the velocity of the laser-induced shock waves has thus been demonstrated for the first time. C1 US Army, Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21009 USA. RP Gottfried, JL (reprint author), US Army, Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21009 USA. EM jennifer.l.gottfried.civ@mail.mil RI Gottfried, Jennifer/G-6333-2010 NR 70 TC 6 Z9 6 U1 6 U2 82 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1463-9076 EI 1463-9084 J9 PHYS CHEM CHEM PHYS JI Phys. Chem. Chem. Phys. PD OCT 21 PY 2014 VL 16 IS 39 BP 21452 EP 21466 DI 10.1039/c4cp02903h PG 15 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA AQ8JX UT WOS:000343072900047 PM 25182866 ER PT J AU Shterengas, L Liang, R Kipshidze, G Hosoda, T Belenky, G Bowman, SS Tober, RL AF Shterengas, Leon Liang, Rui Kipshidze, Gela Hosoda, Takashi Belenky, Gregory Bowman, Sherrie S. Tober, Richard L. TI Cascade type-I quantum well diode lasers emitting 960mW near 3 mu m SO APPLIED PHYSICS LETTERS LA English DT Article AB The cascade pumping scheme reduced the threshold current density of high power type-I quantum well GaSb-based lambda similar to 3 mu m diode lasers down to similar to 100 A/cm(2) at room temperature. Laser hetero-structures had single GaInAsSb quantum well gain stages connected in series by means of GaSb/AlSb/InAs tunnel junctions followed by InAs/AlSb electron injectors. Devices with densely stacked two and three gain stages and 100-mu m-wide aperture demonstrated peak power conversion efficiency of 16% and continuous wave output power of 960 mW. Corresponding narrow ridge lasers demonstrated above 100mW of output power. The experiment showed that the bandwidth of the gain and its rate of increase with current depended strongly on the thickness of AlSb layer separating electron injectors from quantum wells. The possible impact of electron injector interfaces and ionized impurities on the carrier scattering and recombination in the active quantum well is discussed. (C) 2014 AIP Publishing LLC. C1 [Shterengas, Leon; Liang, Rui; Kipshidze, Gela; Hosoda, Takashi; Belenky, Gregory] SUNY Stony Brook, Stony Brook, NY 11794 USA. [Bowman, Sherrie S.; Tober, Richard L.] Army Res Lab, Adelphi, MD 20783 USA. RP Shterengas, L (reprint author), SUNY Stony Brook, Stony Brook, NY 11794 USA. EM leon.shterengas@stonybrook.edu FU U.S. Army Research Office [W911NF1420070] FX This work was supported by the U.S. Army Research Office, Grant W911NF1420070. NR 15 TC 15 Z9 15 U1 1 U2 20 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD OCT 20 PY 2014 VL 105 IS 16 AR 161112 DI 10.1063/1.4900506 PG 4 WC Physics, Applied SC Physics GA AS6GS UT WOS:000344363000012 ER PT J AU Mait, JN AF Mait, Joseph N. TI Reflections on 35 years with Applied Optics: outgoing editorial SO APPLIED OPTICS LA English DT Editorial Material AB Applied Optics' Editor-in-Chief, Joseph N. Mait reflects on his experience as a reader, author, reviewer and eventual editor of the journal. Dr. Mait also introduces the incoming Editor-in-Chief, Ronald G. Driggers and acknowledges outgoing Division Editor, T.-C. Poon. (C) 2014 Optical Society of America C1 US Army Res Lab, Adelphi, MD 20783 USA. RP Mait, JN (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM joseph.n.mait2.civ@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 3 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD OCT 20 PY 2014 VL 53 IS 30 DI 10.1364/AO.53.000ED1 PG 2 WC Optics SC Optics GA AR9TE UT WOS:000343918300001 PM 25402809 ER PT J AU Khiabanian, H Carpenter, Z Kugelman, J Chan, J Trifonov, V Nagle, E Warren, T Iversen, P Bavari, S Palacios, G Rabadan, R AF Khiabanian, Hossein Carpenter, Zachary Kugelman, Jeffrey Chan, Joseph Trifonov, Vladimir Nagle, Elyse Warren, Travis Iversen, Patrick Bavari, Sina Palacios, Gustavo Rabadan, Raul TI Viral diversity and clonal evolution from unphased genomic data SO BMC GENOMICS LA English DT Article; Proceedings Paper CT 12th Annual Research in Computational Molecular Biology (RECOMB) Satellite Workshop on Comparative Genomics CY OCT 19-22, 2014 CL Cold Spring Harbor Lab, Cold Spring Harbor, NY HO Cold Spring Harbor Lab ID MOLECULAR EVOLUTION; DIVERGENCE TIMES; VIRUS; SEQUENCES; ORIGINS; SWINE; RATES AB Background: Clonal expansion is a process in which a single organism reproduces asexually, giving rise to a diversifying population. It is pervasive in nature, from within-host pathogen evolution to emergent infectious disease outbreaks. Standard phylogenetic tools rely on full-length genomes of individual pathogens or population consensus sequences (phased genotypes). Although high-throughput sequencing technologies are able to sample population diversity, the short sequence reads inherent to them preclude assessing whether two reads originate from the same clone (unphased genotypes). This obstacle severely limits the application of phylogenetic methods and investigation of within-host dynamics of acute infections using this rich data source. Methods: We introduce two measures of diversity to study the evolution of clonal populations using unphased genomic data, which eliminate the need to construct full-length genomes. Our method follows a maximum likelihood approach to estimate evolutionary rates and times to the most recent common ancestor, based on a relaxed molecular clock model; independent of a growth model. Deviations from neutral evolution indicate the presence of selection and bottleneck events. Results: We evaluated our methods in silico and then compared it against existing approaches with the well-characterized 2009 H1N1 influenza pandemic. We then applied our method to high-throughput genomic data from marburgvirus-infected non-human primates and inferred the time of infection and the intra-host evolutionary rate, and identified purifying selection in viral populations. Conclusions: Our method has the power to make use of minor variants present in less than 1% of the population and capture genomic diversification within days of infection, making it an ideal tool for the study of acute RNA viral infection dynamics. C1 [Khiabanian, Hossein; Carpenter, Zachary; Chan, Joseph; Trifonov, Vladimir; Rabadan, Raul] Columbia Univ, Coll Phys & Surg, Dept Syst Biol, New York, NY 10027 USA. [Khiabanian, Hossein; Carpenter, Zachary; Chan, Joseph; Trifonov, Vladimir; Rabadan, Raul] Columbia Univ, Coll Phys & Surg, Dept Biomed Informat, New York, NY USA. [Kugelman, Jeffrey; Nagle, Elyse; Warren, Travis; Bavari, Sina; Palacios, Gustavo] US Army, Med Res Inst Infect Dis, Genom Div, Ft Detrick, MD 21702 USA. [Iversen, Patrick] Sarepta Therapeut, Discovery Unit, Corvallis, OR USA. RP Khiabanian, H (reprint author), Columbia Univ, Coll Phys & Surg, Dept Syst Biol, New York, NY 10027 USA. EM hossein@c2b2.columbia.edu; rabadan@c2b2.columbia.edu RI Palacios, Gustavo/I-7773-2015; OI Palacios, Gustavo/0000-0001-5062-1938; Khiabanian, Hossein/0000-0003-1446-4394 NR 31 TC 1 Z9 1 U1 1 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2164 J9 BMC GENOMICS JI BMC Genomics PD OCT 17 PY 2014 VL 15 SU 6 AR S17 DI 10.1186/1471-2164-15-S6-S17 PG 8 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA AU5ZY UT WOS:000345683000018 PM 25573168 ER PT J AU Fracisco, S Teja-isavadharm, P Gettayacamin, M Berman, J Li, QG Melendez, V Saunders, D Xie, LS Ohrt, C AF Fracisco, Susan Teja-isavadharm, Paktiya Gettayacamin, Montip Berman, Jonathan Li, Qigui Melendez, Victor Saunders, David Xie, Lisa Ohrt, Colin TI Anti-relapse activity of mirincamycin in the Plasmodium cynomolgi sporozoite-infected Rhesus monkey model SO MALARIA JOURNAL LA English DT Article DE Malaria; P. vivax; Hypnozoites; Relapse; Mirincamycin; Rhesus monkey ID FALCIPARUM-MALARIA; MACACA-MULATTA AB Background: Mirincamycin is a close analog of the drug clindamycin used to treat Plasmodium falciparum blood stages. The clinical need to treat Plasmodium vivax dormant liver stages and prevent relapse with a drug other than primaquine led to the evaluation of mirinicamycin against liver stages in animals. Methods: cis-mirinicamycin and trans-mirinicamycin were evaluated as prophylaxis against early liver stages of Plasmodium berghei in mice and as antirelapse hypnozoiticides against Plasmodium cynomolgi in the Rhesus monkey (Macaca mulatta). Results: Mirincamycin was very effective against early liver stages of P. berghei in mice: both cis and trans enantiomers were 90-100% causally prophylactic at 3.3 mg/kg/day for 3 days orally. Both cis and trans mirincamycin, however, failed to kill dormant liver stages (hypnozoites) in the P. cynomolgi infected Rhesus monkey, the only preclinical hypnozoite model. Mirincamycin enantiomers at 80 mg/kg/day for 7 days orally, a dose that generated exposures comparable to that seen clinically, did not prevent relapse in any of four monkeys. Conclusions: Although efficacy against early liver stages of P. berghei was thought to correlate with anti-hypnozoite activity in primates, for mirincamycin, at least, there was no correlation. The negative P. cynomolgi hypnozoite data from Rhesus monkeys indicates that mirincamycin is unlikely to have potential as a clinical anti-relapse agent. C1 [Fracisco, Susan; Berman, Jonathan; Li, Qigui; Melendez, Victor; Xie, Lisa; Ohrt, Colin] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Teja-isavadharm, Paktiya; Saunders, David] Armed Forces Res Inst Med Sci, US Army Med Component, Dept Immunol & Med, Bangkok 10400, Thailand. [Gettayacamin, Montip] Armed Forces Res Inst Med Sci, US Army Med Component, Dept Vet Med, Bangkok 10400, Thailand. RP Berman, J (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. EM jbe9320457@aol.com NR 11 TC 1 Z9 1 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD OCT 17 PY 2014 VL 13 AR 409 DI 10.1186/1475-2875-13-409 PG 6 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AU6KY UT WOS:000345713200001 PM 25326032 ER PT J AU Pickle, NT Wilken, JM Aldridge, JM Neptune, RR Silverman, AK AF Pickle, Nathaniel T. Wilken, Jason M. Aldridge, Jennifer M. Neptune, Richard R. Silverman, Anne K. TI Whole-body angular momentum during stair walking using passive and powered lower-limb prostheses SO JOURNAL OF BIOMECHANICS LA English DT Article DE Biomechanics; Stair climbing; Amputee; Falls; Dynamic balance ID TRANSTIBIAL AMPUTATION; GAIT; BIOMECHANICS; AMBULATION; KINEMATICS; MECHANICS; KINETICS; RECOVERY; AMPUTEES; BALANCE AB Individuals with a unilateral transtibial amputation have a greater risk of falling compared to able-bodied individuals, and falling on stairs can lead to serious injuries. Individuals with transtibial amputations have lost ankle plantarflexor muscle function, which is critical for regulating whole-body angular momentum to maintain dynamic balance. Recently, powered prostheses have been designed to provide active ankle power generation with the goal of restoring biological ankle function. However, the effects of using a powered prosthesis on the regulation of whole-body angular momentum are unknown. The purpose of this study was to use angular momentum to evaluate dynamic balance in individuals with a transtibial amputation using powered and passive prostheses relative to able-bodied individuals during stair ascent and descent. Ground reaction forces, external moment arms, and joint powers were also investigated to interpret the angular momentum results. A key result was that individuals with an amputation had a larger range of sagittal-plane angular momentum during prosthetic limb stance compared to able-bodied individuals during stair ascent. There were no significant differences in the frontal, transverse, or sagittal-plane ranges of angular momentum or maximum magnitude of the angular momentum vector between the passive and powered prostheses during stair ascent or descent. These results indicate that individuals with an amputation have altered angular momentum trajectories during stair walking compared to able-bodied individuals, which may contribute to an increased fall risk. The results also suggest that a powered prosthesis provides no distinct advantage over a passive prosthesis in maintaining dynamic balance during stair walking. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Pickle, Nathaniel T.; Silverman, Anne K.] Colorado Sch Mines, Dept Mech Engn, Golden, CO 80401 USA. [Wilken, Jason M.; Aldridge, Jennifer M.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ctr Intrepid, Jbsa Ft Sam Houston, TX 78234 USA. [Neptune, Richard R.] Univ Texas Austin, Dept Mech Engn, Austin, TX 78712 USA. RP Silverman, AK (reprint author), Colorado Sch Mines, Dept Mech Engn, 1500 Illinois St, Golden, CO 80401 USA. EM asilverm@mines.edu RI Silverman, Anne/M-2727-2016; OI Silverman, Anne/0000-0002-2228-4548; Wilken, Jason/0000-0002-5556-7667 FU U.S. Army Telemedicine and Advanced Technology Research Center; Center for Rehabilitation Sciences Research (CRSR), Department of Physical Medicine and Rehabilitation, Uniformed Services University of Health Sciences, Bethesda, MD FX Support partially provided by the U.S. Army Telemedicine and Advanced Technology Research Center (to JMW) and by the Center for Rehabilitation Sciences Research (CRSR), Department of Physical Medicine and Rehabilitation, Uniformed Services University of Health Sciences, Bethesda, MD. NR 30 TC 5 Z9 5 U1 5 U2 25 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0021-9290 EI 1873-2380 J9 J BIOMECH JI J. Biomech. PD OCT 17 PY 2014 VL 47 IS 13 BP 3380 EP 3389 DI 10.1016/j.jbiomech.2014.08.001 PG 10 WC Biophysics; Engineering, Biomedical SC Biophysics; Engineering GA AR8WK UT WOS:000343852000016 PM 25213178 ER PT J AU Loh, GC Nigam, S Mallick, G Pandey, R AF Loh, G. C. Nigam, Sandeep Mallick, G. Pandey, Ravindra TI Carbon-Doped Boron Nitride Nanomesh: Stability and Electronic Properties of Adsorbed Hydrogen and Oxygen SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID H-BN; CORRUGATED MONOLAYER; STORAGE MATERIALS; PERFORMANCE; NANOTUBES; MOLECULES; CU(111); NI(111); GROWTH; LAYER AB Atomic or molecular preferential adsorption on a surface template provides a facile and feasible means of fabricating ordered low-dimensional nanostructures with tailored functionality for novel applications. In this study, we demonstrate that functionality of C-doped BN nanomesh can be tailored by an external electric field which modifies the strength of the adsorbate binding to the nanomesh. Specifically, selective binding of H, O, H-2, and O-2 at various sites of the C-doped nanomeshwithin the pore, on the wire, and at an intermediate siteis investigated with density functional theory. The calculated results find that atomic species are bound, but the molecular species are not bound to the nanomesh. We have shown that it is possible to modify the adsorbate binding energy with the application of an external field, such that the molecular H-2 can be bound at the pore region of the nanomesh. Interestingly, the work function of the nanomesh has a close correlation with the adsorbate binding energy with the BN nanomesh. C1 [Loh, G. C.; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. [Loh, G. C.] Inst High Performance Comp, Singapore 138632, Singapore. [Nigam, Sandeep] Bhabha Atom Res Ctr, Div Chem, Bombay 400085, Maharashtra, India. [Mallick, G.] US Army, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Loh, GC (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. EM jgloh@mtu.edu; pandey@mtu.edu FU A*STAR FX G.C.L. gratefully acknowledges A*STAR for funding under the A*STAR International Fellowship (2013-2015). The authors thank D. R. Banyai for his help with one of the figures. The computations were performed on the MTU Superior duster, and support from Dr. S. Gowtham is appreciated. NR 72 TC 4 Z9 4 U1 7 U2 54 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD OCT 16 PY 2014 VL 118 IS 41 BP 23888 EP 23896 DI 10.1021/jp508229w PG 9 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA AR1GL UT WOS:000343333600050 ER PT J AU Stratman, KN Overholt, WA Cuda, JP Mukherjee, A Diaz, R Netherland, MD Wilson, PC AF Stratman, Karen N. Overholt, William A. Cuda, James P. Mukherjee, A. Diaz, R. Netherland, Michael D. Wilson, Patrick C. TI Temperature-Dependent Development, Cold Tolerance, and Potential Distribution of Cricotopus lebetis (Diptera: Chironomidae), a Tip Miner of Hydrilla verticillata (Hydrocharitaceae) SO JOURNAL OF INSECT SCIENCE LA English DT Article DE biological control; distribution; temperature requirement; degree day; predicted distribution ID BIOLOGICAL-CONTROL AGENT; SPECIES DISTRIBUTION; FLORIDA; MODELS; MAXIMUM; SPREAD; RANGE AB A chironomid midge, Cricotopus lebetis (Sublette) (Diptera: Chironomidae), was discovered attacking the apical meristems of Hydrilla verticillata (L.f. Royle) in Crystal River, Citrus Co., Florida in 1992. The larvae mine the stems of Hydrilla verticillata and cause basal branching and stunting of the plant. Temperature-dependent development, cold tolerance, and the potential distribution of the midge were investigated. The results of the temperature-dependent development study showed that optimal temperatures for larval development were between 20 and 30 degrees C, and these data were used to construct a map of the potential number of generations per year of Cricotopus lebetis in Florida. Data from the cold tolerance study, in conjunction with historical weather data, were used to generate a predicted distribution of Cricotopus lebetis in the United States. A distribution was also predicted using an ecological niche modeling approach by characterizing the climate at locations where Cricotopus lebetis is known to occur and then finding other locations with similar climate. The distributions predicted using the two modeling approaches were not significantly different and suggested that much of the southeastern United States was climatically suitable for Cricotopus lebetis. C1 [Stratman, Karen N.; Overholt, William A.; Diaz, R.; Wilson, Patrick C.] Univ Florida, Indian River Res & Educ Ctr, Ft Pierce, FL 34946 USA. [Cuda, James P.] Univ Florida, Dept Entomol & Nematol, Gainesville, FL 32611 USA. [Mukherjee, A.] Texas A&M Univ, Dept Entomol, College Stn, TX 77843 USA. [Netherland, Michael D.] US Army, Engineer Res & Dev Ctr, Ctr Aquat & Invas Plants, Gainesville, FL USA. RP Overholt, WA (reprint author), Univ Florida, Indian River Res & Educ Ctr, Ft Pierce, FL 34946 USA. EM billover@ufl.edu FU Wildlife Conservation Commission; United States Department of Agriculture, Hydrilla Integrated Pest Management Risk Avoidance and Mitigation grant FX We thank the Florida Fish and Wildlife Conservation Commission and the United States Department of Agriculture, Hydrilla Integrated Pest Management Risk Avoidance and Mitigation grant for providing funding for this research. NR 50 TC 2 Z9 2 U1 0 U2 4 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1536-2442 EI 2250-2645 J9 J INSECT SCI JI J Insect Sci. PD OCT 15 PY 2014 VL 14 DI 10.1093/jisesa/ieu015 PG 8 WC Entomology SC Entomology GA CB6XN UT WOS:000349770300012 PM 25347841 ER PT J AU Gresty, KJ Gray, KA Bobogare, A Taleo, G Hii, J Wini, L Cheng, Q Waters, NC AF Gresty, Karryn J. Gray, Karen-Ann Bobogare, Albino Taleo, George Hii, Jeffrey Wini, Lyndes Cheng, Qin Waters, Norman C. TI Genetic mutations in pfcrt and pfmdr1 at the time of artemisinin combination therapy introduction in South Pacific islands of Vanuatu and Solomon Islands SO MALARIA JOURNAL LA English DT Article DE Plasmodium falciparum; Chloroquine; pfcrt; Microsatellite markers; Surveillance; Molecular markers; Vanuatu; Solomon Islands ID PLASMODIUM-FALCIPARUM MALARIA; CHLOROQUINE RESISTANCE TRANSPORTER; IN-VIVO SELECTION; ARTEMETHER-LUMEFANTRINE; DRUG-RESISTANCE; AFRICA; AMODIAQUINE; PARASITES; SUSCEPTIBILITY; POLYMORPHISMS AB Background: Chloroquine (CQ), alone or in combination with sulphadoxine-pyrimethamine, was widely used for the treatment of Plasmodium falciparum and Plasmodium vivax for several decades in both Vanuatu and Solomon Islands prior to the introduction of artemether-lumefantrine (AL) in 2008. However, the effect of chloroquine selection on parasite population, which may affect the efficacy of lumefantrine or other partner drugs of artemisinin, has not been well assessed. This study aims to provide baseline data on molecular markers (pfcrt and pfmdr1), along with the origins of pfcrt, prior to the introduction of AL. Methods: Blood spots were obtained from epidemiological surveys conducted on Tanna Island, Tafea Province, Vanuatu and Temotu Province, Solomon Islands in 2008. Additional samples from Malaita Province, Solomon Islands were collected as part of an artemether-lumefantrine efficacy study in 2008. Plasmodium falciparum pfcrt and pfmdr1 genes were examined for polymorphisms. Microsatellite markers flanking pfcrt were also examined to ascertain origins of CQ resistance. Results: Pfcrt analysis revealed 100% of parasites from Tafea Province, Vanuatu and Malaita Province, Solomon Islands and 98% of parasites from Temotu Province, Solomon Islands carried the K76T polymorphism that confers CQ resistance. Comparison of pfcrt allelic patterns and microsatellite markers flanking pfcrt revealed six haplotypes with more than 70% of isolates possessing haplotypes very similar to those observed in Papua New Guinea. The dominant (98.5%) pfmdr1 allele across all island groups was YYCND. Conclusions: Prior to the introduction of AL in the Solomon Islands and Vanuatu, P. falciparum isolates possessed point mutations known to confer CQ resistance and possibly associated with a decreased susceptibility to quinine and halofantrine, but an increased susceptibility to artemisinin and lumefantrine. Overall, pfcrt allelic types and the flanking microsatellite markers exhibited similarities to those of Papua New Guinea, suggesting these parasites share a common ancestry. The current use of AL for both P. falciparum and P. vivax infections will enable changes in these markers, in the absence of CQ pressure, to be monitored. C1 [Gresty, Karryn J.; Gray, Karen-Ann; Cheng, Qin; Waters, Norman C.] Australian Army Malaria Inst, Brisbane, Qld, Australia. [Gresty, Karryn J.; Gray, Karen-Ann; Cheng, Qin] QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia. [Bobogare, Albino; Wini, Lyndes] Minist Hlth, Malaria & Vector Borne Dis Control Program, Honiara, Solomon Islands. [Taleo, George] Minist Hlth, Vector Borne Dis Control Program, Port Vila, Vanuatu. [Hii, Jeffrey] James Cook Univ, Sch Publ Hlth Trop Med & Rehabil Sci, Townsville, Qld 4811, Australia. [Waters, Norman C.] Walter Reed Army Inst Res, Malaria Vaccine Branch, Mil Malaria Res Program, Silver Spring, MD USA. RP Waters, NC (reprint author), Australian Army Malaria Inst, Brisbane, Qld, Australia. EM norman.c.waters2.mil@mail.mil FU AusAID through Pacific Malaria Initiative Supporting Centre (PacMISC), University of Queensland; Department of Defense, Global Emerging Infections Surveillance Program (DoD-GEIS), USA FX We thank the Ministries of Health Solomon Islands and Vanuatu for support and approval to conduct these studies. We thank the people of the Solomon Islands and Vanuatu for their hospitality and willingness to participate in the malaria survey. We are grateful to Dr Bridget Appleyard and Dr Dorina Bustos for facilitating the therapeutic efficacy studies and standardizing the filter paper preparation in Malaita. Funding for the malaria survey was provided by AusAID through Pacific Malaria Initiative Supporting Centre (PacMISC), University of Queensland. Genotyping analysis and drug resistance profiling was financially supported by Department of Defense, Global Emerging Infections Surveillance Program (DoD-GEIS), USA. NR 45 TC 1 Z9 2 U1 0 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD OCT 15 PY 2014 VL 13 AR 406 DI 10.1186/1475-2875-13-406 PG 9 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AU6KT UT WOS:000345712800001 PM 25318907 ER PT J AU Baird, DC Seehusen, DA Bode, DV AF Baird, Drew C. Seehusen, Dean A. Bode, David V. TI Enuresis in Children: A Case-Based Approach SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID MONOSYMPTOMATIC NOCTURNAL ENURESIS; PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; CONTINENCE-SOCIETY; US CHILDREN; DESMOPRESSIN; PREVALENCE; PSEUDOEPHEDRINE; STANDARDIZATION; EPIDEMIOLOGY AB Enuresis is defined as intermittent urinary incontinence during sleep in a child at least five years of age. Approximately 5% to 10% of all seven-year-olds have enuresis, and an estimated 5 to 7 million children in the United States have enuresis. The pathophysiology of primary nocturnal enuresis involves the inability to awaken from sleep in response to a full bladder, coupled with excessive nighttime urine production or a decreased functional capacity of the bladder. Initial evaluation should include a history, physical examination, and urinalysis. Several conditions, such as constipation, obstructive sleep apnea, diabetes mellitus, diabetes insipidus, chronic kidney disease, and psychiatric disorders, are associated with enuresis. If identified, these conditions should be evaluated and treated. Treatment of primary monosymptomatic enuresis (i.e., the only symptom is nocturnal bed-wetting in a child who has never been dry) begins with counseling the child and parents on effective behavioral modifications. First-line treatments for enuresis include bed alarm therapy and desmopressin. The choice of therapy is based on the child's age and nighttime voiding patterns, and the desires of the child and family. Referral to a pediatric urologist is indicated for children with primary enuresis refractory to standard and combination therapies, and for children with some secondary causes of enuresis, including urinary tract malformations, recurrent urinary tract infections, or neurologic disorders. (Copyright (C) 2014 American Academy of Family Physicians.) C1 [Baird, Drew C.] Carl R Darnall Army Med Ctr, Family Med Residency Program, Ft Hood, TX USA. [Seehusen, Dean A.] Eisenhower Army Med Ctr, Dept Family & Community Med, Ft Gordon, GA USA. [Bode, David V.] Eisenhower Army Med Ctr, Family Med Residency Program, Ft Gordon, GA USA. [Seehusen, Dean A.] Ft Belvoir Va Community Hosp, Family Med Residency Program, Ft Belvoir, VA USA. RP Baird, DC (reprint author), Carl R Darnall Army Med Ctr, 713 End O Trail, Harker Hts, TX 76548 USA. EM drew.c.baird.mil@mail.mil NR 41 TC 0 Z9 0 U1 2 U2 7 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X EI 1532-0650 J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD OCT 15 PY 2014 VL 90 IS 8 BP 560 EP 568 PG 9 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA AR6EK UT WOS:000343676000008 PM 25369644 ER PT J AU Buettner, LC Leduc, CA Glover, TG AF Buettner, Leonard C. LeDuc, Charles A. Glover, T. Grant TI Instantaneous Ignition of Activated Carbon SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH LA English DT Article ID OXIDATION; BEHAVIOR AB The spontaneous ignition temperature as defined using the American Society for Testing and Materials (ASTM) methods may not accurately determine the temperature at which carbon will combust when a step change in bed temperature occurs; therefore, an instantaneous ignition temperature is defined. Seven different activated carbons have been heated at various heating rates in three different bed configurations, and the data show that the instantaneous ignition temperature can be significantly lower than the spontaneous ignition temperature. In some cases, the carbon ignited at temperatures 100 degrees C lower than the spontaneous ignition temperature. The results show that ignition temperatures are dependent not only on the carbon source and bed dimensions but also on the rate of heating used in the experiment. The results emphasize the importance of evaluating carbon combustion with experiments that closely resemble the operational conditions of the fixed-bed C1 [Buettner, Leonard C.; LeDuc, Charles A.] US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Glover, T. Grant] Univ S Alabama, Dept Chem & Biomol Engn, Mobile, AL 36688 USA. RP Glover, TG (reprint author), Univ S Alabama, Dept Chem & Biomol Engn, 150 Jaguar Dr SH4136, Mobile, AL 36688 USA. EM glover@southalabama.edu NR 14 TC 0 Z9 0 U1 3 U2 14 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0888-5885 J9 IND ENG CHEM RES JI Ind. Eng. Chem. Res. PD OCT 15 PY 2014 VL 53 IS 41 BP 15793 EP 15797 DI 10.1021/ie502343y PG 5 WC Engineering, Chemical SC Engineering GA AR0QT UT WOS:000343277100001 ER PT J AU Shukla, MK Hill, F AF Shukla, Manoj K. Hill, Frances TI Plane-Wave Density Functional Theory Investigation of Adsorption of 2,4,6-Trinitrotoluene on Al-Hydroxylated (0001) Surface of (4 x 4) alpha-Alumina SO JOURNAL OF COMPUTATIONAL CHEMISTRY LA English DT Article DE TNT adsorption; alpha-alumina; surface relaxation; plane-wave DFT; PBE; vdW-DF2; ultrasoft pseudopotential; Al-hydroxylation ID GENERALIZED GRADIENT APPROXIMATION; 1ST PRINCIPLES; WATER; ALPHA-AL2O3; CHEMISTRY; DYNAMICS; CRYSTAL; ALKANES AB This article reports the results of the theoretical investigation of adsorption of 2,4,6-trinitrotoluene (TNT) on Al-hydroxylated (0001) surface of (4 3 4) alpha-alumina (alpha-Al2O3) using plane-wave Density Functional Theory. Sixteen water molecules were used to hydroxylate the alumina surface. The Perdew-Burke-Ernzer-hof functional and the recently developed van der Waals functional (vdW-DF2) were used. The interaction of electron with core was accounted using the Vanderbilt ultrasoft pseudopotentials. It was found that hydroxylation has significant influence on the geometry of alumina and such changes are prominent up to few layers from the surface. Particularly, due to the Al-hydroxylation the oxygen layers are decomposed into sublayers and such partitioning becomes progressively weaker for interior layers. Moreover, the nature of TNT adsorption interaction is changed from covalent type on the pristine alumina surface to hydrogen-bonding interaction on the Al-hydroxylated alumina surface. TNT in parallel orientation forms several hydrogen bonds compared to that in the perpendicular orientation with hydroxyl groups of the Al-hydroxylated alumina surface. Therefore, the parallel orientation will be present in the adsorption of TNT on Al-hydroxylated (0001) surface of alpha-alumina. Further, the vdW-DF2 van der Waals functional was found to be most suitable and should be used for such surface adsorption investigation. (C) 2014 Wiley Periodicals, Inc. C1 [Shukla, Manoj K.; Hill, Frances] US Army, Environm Lab, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Shukla, MK (reprint author), US Army, Environm Lab, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Manoj.K.Shukla@usace.army.mil NR 35 TC 2 Z9 2 U1 1 U2 15 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0192-8651 EI 1096-987X J9 J COMPUT CHEM JI J. Comput. Chem. PD OCT 15 PY 2014 VL 35 IS 27 BP 1977 EP 1985 DI 10.1002/jcc.23712 PG 9 WC Chemistry, Multidisciplinary SC Chemistry GA AQ4EZ UT WOS:000342747400004 PM 25124797 ER PT J AU Collier, ZA Bates, ME Wood, MD Linkov, I AF Collier, Zachary A. Bates, Matthew E. Wood, Matthew D. Linkov, Igor TI Stakeholder engagement in dredged material management decisions SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Stakeholder engagement; Group decision making; Sediment management; Collaborative model building; Multi-criteria decision analysis; Long Island Sound ID PRODUCTIVITY LOSS; COMMUNICATION; INVOLVEMENT; SEDIMENT; RIVER AB Dredging and disposal issues often become controversial with local stakeholders because of their competing interests. These interests tend to manifest themselves in stakeholders holding onto entrenched positions, and deadlock can result without a methodology to move the stakeholder group past the status quo. However, these situations can be represented as multi-stakeholder, multi-criteria decision problems. In this paper, we describe a case study in which multi-criteria decision analysis was implemented in a multi-stakeholder setting in order to generate recommendations on dredged material placement for Long Island Sound's Dredged Material Management Plan. A working-group of representatives from various stakeholder organizations was formed and consulted to help prioritize sediment placement sites for each dredging center in the region by collaboratively building a multi-criteria decision model. The resulting model framed the problem as several alternatives, criteria, sub-criteria, and metrics relevant to stakeholder interests in the Long Island Sound region. An elicitation of values, represented as criteria weights, was then conducted. Results show that in general, stakeholders tended to agree that all criteria were at least somewhat important, and on average there was strong agreement on the order of preferences among the diverse groups of stakeholders. By developing the decision model iteratively with stakeholders as a group and soliciting their preferences, the process sought to increase stakeholder involvement at the front-end of the prioritization process and lead to increased knowledge and consensus regarding the importance of site-specific criteria. Published by Elsevier B.V. C1 [Collier, Zachary A.; Bates, Matthew E.; Wood, Matthew D.; Linkov, Igor] US Army Engineer Res & Dev Ctr, Concord, MA 01742 USA. RP Linkov, I (reprint author), 696 Virginia Rd, Concord, MA 01742 USA. EM Igor.Linkov@usace.army.mil OI Wood, Matthew/0000-0002-1140-1526 FU US Army Corps of Engineers, New England District and Dredging Operations and Environmental Research Program FX This work was supported by the US Army Corps of Engineers, New England District and Dredging Operations and Environmental Research Program. Permission was granted by the USACE Chief of Engineers to publish this material. The views and opinions expressed in this paper are those of the individual authors and not those of the US Army, or other sponsor organizations. NR 48 TC 3 Z9 3 U1 1 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD OCT 15 PY 2014 VL 496 BP 248 EP 256 DI 10.1016/j.scitotenv.2014.07.044 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA AP7GK UT WOS:000342245600029 PM 25089686 ER PT J AU Novikov, SV Ting, M Yu, KM Sarney, WL Martin, RW Svensson, SP Walukiewicz, W Foxon, CT AF Novikov, S. V. Ting, M. Yu, K. M. Sarney, W. L. Martin, R. W. Svensson, S. P. Walukiewicz, W. Foxon, C. T. TI Tellurium n-type doping of highly mismatched amorphous GaNi1-xAsx alloys in plasma-assisted molecular beam epitaxy SO JOURNAL OF CRYSTAL GROWTH LA English DT Article DE Molecular beam epitaxy; Nitrides; Semiconducting III-V materials ID GROWTH; LAYERS AB In this paper we report our study on n-type Te doping of amorphous GaNi1-xAsx layers grown by plasma assisted molecular beam epitaxy. We have used a low temperature PbTe source as a source of tellurium. Reproducible and uniform tellurium incorporation in amorphous GaNi1-xAsx layers has been successfully achieved with a maximum Te concentration of 9 x 10(20) cm(-3). Tellurium incorporation resulted in n-doping of GaN1-xAsx layers with Hall carrier concentrations up to 3 x 10(19) cm(-3) and mobilities of similar to 1 cm(2)/V s. The optimal growth temperature window for efficient Te doping of the amorphous GaNi1-xAsx layers has been determined. (C) 2014 The Authors. Published by Elsevier B.V. C1 [Novikov, S. V.; Foxon, C. T.] Univ Nottingham, Sch Phys & Astron, Nottingham NG7 2RD, England. [Ting, M.; Yu, K. M.; Walukiewicz, W.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA. [Ting, M.] Univ Calif Berkeley, Dept Mech Engn, Berkeley, CA 94720 USA. [Sarney, W. L.; Svensson, S. P.] US Army Res Lab, Adelphi, MD 20783 USA. [Martin, R. W.] Univ Strathclyde, Dept Phys, SUPA, Glasgow G4 0NG, Lanark, Scotland. RP Novikov, SV (reprint author), Univ Nottingham, Sch Phys & Astron, Nottingham NG7 2RD, England. EM Sergei.Novikov@nottingham.ac.uk RI martin, rob/A-7127-2010; OI martin, rob/0000-0002-6119-764X; Yu, Kin Man/0000-0003-1350-9642 FU EPSRC UK [EP/I004203/1, EP/I00467X/1]; US Army Foreign Technology Assessment Support (FTAS) program [W911NF-12-2-0003]; Office of Science, Office of Basic Energy Sciences, Materials Sciences and Engineering Division, of the U.S. Department of Energy [DE-AC02-05CH11231] FX This work was undertaken with support from the EPSRC UK, under grant numbers EP/I004203/1 and EP/I00467X/1. The MBE growth at Nottingham was also supported by the US Army Foreign Technology Assessment Support (FTAS) program (grant no. W911NF-12-2-0003). The characterization work performed at LBNL was supported by the Director, Office of Science, Office of Basic Energy Sciences, Materials Sciences and Engineering Division, of the U.S. Department of Energy under Contract no. DE-AC02-05CH11231. NR 15 TC 2 Z9 2 U1 0 U2 11 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0248 EI 1873-5002 J9 J CRYST GROWTH JI J. Cryst. Growth PD OCT 15 PY 2014 VL 404 BP 9 EP 13 DI 10.1016/j.jcrysgro.2014.06.042 PG 5 WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied SC Crystallography; Materials Science; Physics GA AO5VU UT WOS:000341414600002 ER PT J AU McAuliffe, C Karkkainen, R Yen, C Waisman, H AF McAuliffe, Colin Karkkainen, Ryan Yen, Chian Waisman, Haim TI Numerical modeling of friction stir welded aluminum joints under high rate loading SO FINITE ELEMENTS IN ANALYSIS AND DESIGN LA English DT Article DE Computational mechanics; Shear band; Friction stir weld ID SHEAR-BAND PROPAGATION; ALLOYS; SIMULATIONS AB Prediction of shear band formation and other strain localization processes presents many computational challenges that must be overcome to enable dynamic failure prediction and material design of ductile material systems. The current work presents a finite element based computational framework accounting for this critical deformation process, as applied to a detailed investigation of friction stir welded (FSW) aluminum joints. A stir welded joint has several zones, each with distinct microstructural characteristics and material properties. For applications in Army land vehicles, which may be subject to under-body blast, an understanding of the energy absorption capability of these joints is needed. Thus material inhomogeneity, dynamic loading, and detailed understanding of small scale failure processes must all be accounted for to accurately model FSW material behavior. In this study, an implicit nonlinear consistent (INC) or monolithic solution technique is used to predict shear band formation and estimate the energy absorption and failure strain of a stir welded aluminum joint. It has been shown that failure initiating at material interface regions can be predicted, and furthermore that abrupt material property gradients predominantly contribute to FSW joint failure. (C) 2014 Elsevier B.V. All rights reserved. C1 [McAuliffe, Colin; Waisman, Haim] Columbia Univ, Dept Civil Engn & Engn Mech, New York, NY 10027 USA. [Karkkainen, Ryan] Univ Miami, Dept Mech & Aerosp Engn, Coral Gables, FL 33146 USA. [Yen, Chian] US Army, Res Lab, Mat & Mfg Sci Div, Aberdeen Proving Ground, MD 21005 USA. RP Karkkainen, R (reprint author), Univ Miami, Dept Mech & Aerosp Engn, Coral Gables, FL 33146 USA. EM r.karkkainen@miami.edu FU Army Research Office, the Mechanical Sciences Division, through ARO [W911NF-13-1-0238] FX The financial support of the Army Research Office, the Mechanical Sciences Division, through ARO funding No. W911NF-13-1-0238, is gratefully acknowledged. NR 37 TC 0 Z9 0 U1 2 U2 43 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-874X EI 1872-6925 J9 FINITE ELEM ANAL DES JI Finite Elem. Anal. Des. PD OCT 15 PY 2014 VL 89 BP 8 EP 18 DI 10.1016/j.finel.2014.04.012 PG 11 WC Mathematics, Applied; Mechanics SC Mathematics; Mechanics GA AL0QW UT WOS:000338832800002 ER PT J AU Gresty, KJ Gray, KA Bobogare, A Wini, L Taleo, G Hii, J Cheng, Q Waters, NC AF Gresty, Karryn J. Gray, Karen-Ann Bobogare, Albino Wini, Lyndes Taleo, George Hii, Jeffrey Cheng, Qin Waters, Norman C. TI Genetic mutations in Plasmodium falciparum and Plasmodium vivax dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) in Vanuatu and Solomon Islands prior to the introduction of artemisinin combination therapy SO MALARIA JOURNAL LA English DT Article DE Plasmodium falciparum; Plasmodium vivax; Surveillance; Molecular markers; Sulphadoxine-pyrimethamine; dhfr; dhps; Vanuatu; Solomon Islands ID SULFADOXINE-PYRIMETHAMINE; MOLECULAR MARKERS; CHLOROQUINE/SULPHADOXINE-PYRIMETHAMINE; POINT MUTATIONS; AMINO-ACID; RESISTANCE; MALARIA; CHLOROQUINE; CHILDREN; FAILURE AB Background: Plasmodium falciparum and Plasmodium vivax are endemic in Vanuatu and the Solomon Islands. While both countries have introduced artemether-lumefantrine (AL) as first-line therapy for both P. falciparum and P. vivax since 2008, chloroquine and sulphadoxine-pyrimethamine (SP) were used as first-line therapy for many years prior to the introduction of AL. Limited data are available on the extent of SP resistance at the time of policy change. Methods: Blood spots were obtained from epidemiological surveys conducted on Tanna Island, Tafea Province, Vanuatu and Temotu Province, Solomon Islands in 2008. Additional samples from Malaita Province, Solomon Islands were collected as part of an AL therapeutic efficacy study conducted in 2008. Plasmodium vivax and P. falciparum dhfr and dhps genes were sequenced to detect nucleotide polymorphisms. Results: All P. falciparum samples analysed (n = 114) possessed a double mutant pfdhfr allele (C59R/S108N). Additionally, mutation A437G in pfhdps was detected in a small number of samples 2/13, 1/17 and 3/26 from Tanna Island, Vanuatu and Temotu and Malaita Provinces Solomon Islands respectively. Mutations were also common in pvdhfr from Tanna Island, Vanuatu, where 33/51 parasites carried the double amino acid substitution S58R/S117N, while in Temotu and Malaita Provinces, Solomon Islands 32/40 and 39/46 isolates carried the quadruple amino acid substitution F57L/S58R/T61M/S117T in DHFR respectively. No mutations in pvdhps (n = 108) were detected in these three island groups. Conclusion: Prior to the introduction of AL, there was a moderate level of SP resistance in the P. falciparum population that may cause SP treatment failure in young children. Of the P. vivax isolates, a majority of Solomon Islands isolates carried quadruple mutant pvdhfr alleles while a majority of Vanuatu isolates carried double mutant pvdhfr alleles. This suggests a higher level of SP resistance in the P. vivax population in Solomon Islands compared to the sympatric P. falciparum population and there is a higher level of SP resistance in P. vivax parasites from Solomon Islands than Vanuatu. This study demonstrates that the change of treatment policy in these countries from SP to ACT was timely. The information also provides a baseline for future monitoring. C1 [Gresty, Karryn J.; Gray, Karen-Ann; Cheng, Qin; Waters, Norman C.] Australian Army Malaria Inst, Brisbane, Qld, Australia. [Gresty, Karryn J.; Gray, Karen-Ann; Cheng, Qin] QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia. [Bobogare, Albino; Wini, Lyndes] Minist Hlth, Malaria & Vector Borne Dis Control Programme, Honiara, Solomon Islands. [Taleo, George] Minist Hlth, Vector Borne Dis Control Program, Port Vila, Vanuatu. [Hii, Jeffrey] James Cook Univ, Sch Publ Hlth Trop Med & Rehabil Sci, Townsville, Qld 4811, Australia. [Waters, Norman C.] Walter Reed Army Inst Res, Malaria Vaccine Branch, Mil Malaria Res Program, Silver Spring, MD USA. RP Waters, NC (reprint author), Australian Army Malaria Inst, Brisbane, Qld, Australia. EM norman.c.waters2.mil@mail.mil FU Ministry of Health Solomon Islands; Ministry of Vanuatu; AusAID through Pacific Malaria Initiative Supporting Centre (PacMISC), University of Queensland; Department of Defense, Global Emerging Infections Surveillance Program (DoD-GEIS), US FX We thank the Ministries of Health Solomon Islands and Vanuatu for support and approval to conduct these studies. We are grateful to Dr Bridget Appleyard and Dr Dorina Bustos for facilitating the therapeutic efficacy studies and standardizing the filter paper preparation in Malaita. We thank the people of the Solomon Islands and Vanuatu for their hospitality and willingness to participate in the malaria survey. Funding for the malaria survey was provided by AusAID through Pacific Malaria Initiative Supporting Centre (PacMISC), University of Queensland. Genotyping analysis and drug resistance profiling was financially supported by Department of Defense, Global Emerging Infections Surveillance Program (DoD-GEIS), US. NR 34 TC 0 Z9 0 U1 0 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD OCT 14 PY 2014 VL 13 AR 402 DI 10.1186/1475-2875-13-402 PG 7 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AS2PI UT WOS:000344121600001 PM 25311473 ER PT J AU Kagina, BMN Tameris, MD Geldenhuys, H Hatherill, M Abel, B Hussey, GD Scriba, TJ Mahomed, H Sadoff, JC Hanekom, WA Mansoor, N Hughes, J de Kock, M Whatney, W Africa, H Krohn, C Veldsman, A Kany, ALK Douoguih, M Pau, MG Hendriks, J McClain, B Benko, J Snowden, MA Hokey, DA AF Kagina, Benjamin M. N. Tameris, Michele D. Geldenhuys, Hennie Hatherill, Mark Abel, Brian Hussey, Gregory D. Scriba, Thomas J. Mahomed, Hassan Sadoff, Jerald C. Hanekom, Willem A. Mansoor, Nazma Hughes, Jane de Kock, Marwou Whatney, Wendy Africa, Hadn Krohn, Colleen Veldsman, Ashley Kany, Angelique Luabeya Kany Douoguih, Macaya Pau, Maria Grazia Hendriks, Jenny McClain, Bruce Benko, Jacqueline Snowden, Margaret A. Hokey, David A. CA 018-402 Clinical Lab Study Team TI The novel tuberculosis vaccine, AERAS-402, is safe in healthy infants previously vaccinated with BCG, and induces dose-dependent CD4 and CD8T cell responses SO VACCINE LA English DT Article DE Tuberculosis vaccines; BCG; AERAS-402; Vaccine-induced T cell immunity; Infants; South Africa ID T-CELLS; POLYFUNCTIONAL CD4(+); IMMUNE-RESPONSES; NEWBORNS; IMMUNOGENICITY; EXPRESSION; FREQUENCY; ADULTS AB Background: Efforts to reduce risk of tuberculosis disease in children include development of effective vaccines. Our aim was to test safety and immunogenicity of the new adenovirus 35-vectored tuberculosis vaccine candidate AERAS-402 in infants, administered as a boost following a prime with the Bacille Calmette-Guerin vaccine. Methods: In a phase 1 randomised, double-blind, placebo-controlled, dose-escalation trial, BCG-vaccinated infants aged 6-9 months were sequentially assigned to four study groups, then randomized to receive an increasing dose-strength of AERAS-402, or placebo. The highest dose group received a second dose of vaccine or placebo 56 days after the first. The primary study outcome was safety. Whole blood intracellular cytokine staining assessed immunogenicity. Results: Forty-two infants received AERAS-402 and 15 infants received placebo. During follow-up of 182 days, an acceptable safety profile was shown with no serious adverse events or discontinuations related to the vaccine. AERAS-402 induced a specific T cell response. A single dose of AERAS-402 induced CD4T cells predominantly expressing single IFN-gamma whereas two doses induced CD4T cells predominantly expressing IFN-gamma, TNF-alpha. and IL-2 together. CD8T cells were induced and were more likely to be present after 2 doses of AERAS-402. Conclusions: AERAS-402 was safe and immunogenic in healthy infants previously vaccinated with BCG at birth. Administration of the highest dose twice may be the most optimal vaccination strategy, based on the induced immunity. Multiple differences in T cell responses when infants are compared with adults vaccinated with AERAS-402, in the same setting and using the same whole blood intracellular cytokine assay, suggest specific strategies may be important for vaccination for each population. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Kagina, Benjamin M. N.; Tameris, Michele D.; Geldenhuys, Hennie; Hatherill, Mark; Abel, Brian; Hussey, Gregory D.; Scriba, Thomas J.; Mahomed, Hassan; Hanekom, Willem A.; Mansoor, Nazma; Hughes, Jane; de Kock, Marwou; Whatney, Wendy; Africa, Hadn; Krohn, Colleen; Veldsman, Ashley; Kany, Angelique Luabeya Kany] Univ Cape Town, Inst Infect Dis & Mol Med, SATVI, ZA-7925 Cape Town, South Africa. [Kagina, Benjamin M. N.; Tameris, Michele D.; Geldenhuys, Hennie; Hatherill, Mark; Abel, Brian; Hussey, Gregory D.; Scriba, Thomas J.; Mahomed, Hassan; Hanekom, Willem A.] Univ Cape Town, Dept Paediat & Child Hlth, ZA-7925 Cape Town, South Africa. [Kagina, Benjamin M. N.; Hussey, Gregory D.] Univ Cape Town, Div Med Microbiol, Vaccines Africa Initiat, ZA-7925 Cape Town, South Africa. [Kagina, Benjamin M. N.; Hussey, Gregory D.] Univ Cape Town, Inst Infect Dis & Mol Med, ZA-7925 Cape Town, South Africa. [Abel, Brian] Singapore Immunol Network, Agcy Sci Technol & Res, Singapore, Singapore. [Mahomed, Hassan] Western Cape Govt & Stellenbosch Univ, Cape Town, South Africa. [Sadoff, Jerald C.; Douoguih, Macaya; Pau, Maria Grazia; Hendriks, Jenny] Crucell Holland BV, NL-2333 CN Leiden, Netherlands. [Hanekom, Willem A.] Bill & Melinda Gates Fdn, Seattle, WA USA. [Mansoor, Nazma; Hughes, Jane; de Kock, Marwou; Whatney, Wendy; Africa, Hadn; Krohn, Colleen; Veldsman, Ashley; Kany, Angelique Luabeya Kany] Univ Cape Town, Sch Child & Adolescent Hlth, ZA-7925 Cape Town, South Africa. [McClain, Bruce; Snowden, Margaret A.; Hokey, David A.] Aeras, Rockville, MD USA. [Benko, Jacqueline] US Army, Med Res Inst Infect Dis, Washington, DC 20310 USA. RP Hanekom, WA (reprint author), Univ Cape Town Hlth Sci, Anzio Rd, ZA-7925 Cape Town, South Africa. EM Willem.Hanekom@uct.ac.za FU Aeras FX Aeras. NR 33 TC 15 Z9 15 U1 0 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD OCT 14 PY 2014 VL 32 IS 45 BP 5908 EP 5917 DI 10.1016/j.vaccine.2014.09.001 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA AR5MZ UT WOS:000343629900004 PM 25218194 ER PT J AU Li, YF Jackson, AC Beyer, FL Knauss, DM AF Li, Yifan Jackson, Aaron C. Beyer, Frederick L. Knauss, Daniel M. TI Poly(2,6-dimethyl-1,4-phenylene oxide) Blended with Poly(vinylbenzyl chloride)-b-polystyrene for the Formation of Anion Exchange Membranes SO MACROMOLECULES LA English DT Article ID ALKALINE FUEL-CELLS; FREE-RADICAL POLYMERIZATION; DYNAMIC-MECHANICAL PROPERTIES; PROTON CONDUCTING MEMBRANES; BLOCK-COPOLYMERS; 2,6-DIMETHYL-1,4-PHENYLENE OXIDE; FUNCTIONALIZED POLYETHYLENE; STYRENE; PPO; POLYSTYRENE AB A block copolymer of poly(vinylbenzyl chloride)-b-polystyrene (PVBC-b-PS) was synthesized through nitroxide-mediated polymerization, then blended with poly(2,6-dimethyl-1,4-phenylene oxide) (PPO) at different compositions, and solution cast to prepare a series of blend films. Differential scanning calorimetry analysis of the PVBC-b-PS and PVBC-b-PS blended with the PPO showed a single glass transition temperature for each of the compositions examined, suggesting that all components in the blend membranes are compatible. The benzyl chloride groups in the blend films were converted to quaternary ammonium groups by reaction with trimethylamine, and the functionalization reached high conversion as characterized by ion exchange capacity (IEC) measurements. The PPO blend anion exchange membranes (AEMs) show improved mechanical properties compared to the styrenic copolymer, particularly in a hydrated condition. The membranes were subjected to thermal and THF/water annealing procedures to study the effect on membrane properties. Small-angle X-ray scattering (SAXS) experiments indicated the formation of a phase-separated morphology in the membrane after annealing with solvent vapor in the presence of water. The ionic conductivities of the blended membranes show an expected increase with increasing IEC and corresponding water uptake. Ionic conductivity and water uptake were found to increase significantly after either annealing in the presence of water and THF or high-temperature annealing in the presence of water. The highest hydroxide conductivity reached 43 mS/cm measured at 60 degrees C in water. C1 [Li, Yifan; Knauss, Daniel M.] Colorado Sch Mines, Dept Chem & Geochem, Golden, CO 80401 USA. [Jackson, Aaron C.; Beyer, Frederick L.] US Army Res Lab, Weapon & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Knauss, DM (reprint author), Colorado Sch Mines, Dept Chem & Geochem, Golden, CO 80401 USA. EM dknauss@mines.edu OI Li, Yifan/0000-0002-9142-0232 FU Army Research Office through MURI [W911NF-10-1-0520]; NSF MRI [CHW-0923537]; Postgraduate Research Participation Program at the US Army Research Laboratory [ORISE 1120-1120-99]; US DOE [DE-AC02-06CH11357] FX This work was funded by the Army Research Office through a MURI (grant # W911NF-10-1-0520). NMR spectroscopy was made possible through a grant from the NSF MRI program (grant # CHW-0923537). A.C.J. was supported by the Postgraduate Research Participation Program at the US Army Research Laboratory, administered by the Oak Ridge Institute of Science and Education through an interagency agreement between the US Department of Energy and Army Research Laboratory (Contract ORISE 1120-1120-99). The authors also thank Blake Whitley and Prof. Kip Findley for their assistance with membrane tensile tests. The use of the Advanced Photon Source, an Office of Science User Facility operated for the US Department of Energy (DOE) Office of Science by Argonne National Laboratory, was supported by the US DOE under contract DE-AC02-06CH11357. NR 66 TC 9 Z9 9 U1 12 U2 97 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0024-9297 EI 1520-5835 J9 MACROMOLECULES JI Macromolecules PD OCT 14 PY 2014 VL 47 IS 19 BP 6757 EP 6767 DI 10.1021/ma500993s PG 11 WC Polymer Science SC Polymer Science GA AQ9SN UT WOS:000343196200027 ER PT J AU West, BJ AF West, Bruce J. TI Colloquium: Fractional calculus view of complexity: A tutorial SO REVIEWS OF MODERN PHYSICS LA English DT Article ID SELF-ORGANIZED CRITICALITY; FLIGHT SEARCH PATTERNS; ANOMALOUS DIFFUSION; LEVY FLIGHTS; WANDERING ALBATROSSES; ENHANCED DIFFUSION; DYNAMICS; NOISE; FLUCTUATIONS; NETWORKS AB The fractional calculus has been part of the mathematics and science literature for 310 years. However, it is only in the past decade or so that it has drawn the attention of mainstream science as a way to describe the dynamics of complex phenomena with long-term memory, spatial heterogeneity, along with nonstationary and nonergodic statistics. The most recent application encompasses complex networks, which require new ways of thinking about the world. Part of the new cognition is provided by the fractional calculus description of temporal and topological complexity. Consequently, this Colloquium is not so much a tutorial on the mathematics of the fractional calculus as it is an exploration of how complex phenomena in the physical, social, and life sciences that have eluded traditional mathematical modeling become less mysterious when certain historical assumptions such as differentiability are discarded and the ordinary calculus is replaced with the fractional calculus. Exemplars considered include the fractional differential equations describing the dynamics of viscoelastic materials, turbulence, foraging, and phase transitions in complex social networks. C1 US Army, Math & Informat Sci Directorate, Res Off, Res Triangle Pk, NC 27709 USA. RP West, BJ (reprint author), US Army, Math & Informat Sci Directorate, Res Off, Res Triangle Pk, NC 27709 USA. EM bruce.j.west.civ@mail.mil RI West, Bruce/E-3944-2017 FU Army Research Office FX I thank two anonymous referees who made suggestions that improved the paper and found an error in the presentation. I also thank the Army Research Office for support of this research. NR 117 TC 21 Z9 23 U1 3 U2 33 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0034-6861 EI 1539-0756 J9 REV MOD PHYS JI Rev. Mod. Phys. PD OCT 9 PY 2014 VL 86 IS 4 BP 1169 EP 1184 DI 10.1103/RevModPhys.86.1169 PG 16 WC Physics, Multidisciplinary SC Physics GA AR7OW UT WOS:000343770100001 ER PT J AU Tsang, MP Bates, ME Madison, M Linkov, I AF Tsang, Michael P. Bates, Matthew E. Madison, Marcus Linkov, Igor TI Benefits and Risks of Emerging Technologies: Integrating Life Cycle Assessment and Decision Analysis To Assess Lumber Treatment Alternatives SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID TREATED WOOD; COPPER AB Assessing the best options among emerging technologies (e.g., new chemicals, nanotechnologies) is complicated because of trade-offs across benefits and risks that are difficult to quantify given limited and fragmented availability of information. This study demonstrates the integration of multicriteria decision analysis (MCDA) and life cycle assessment (LCA) to address technology alternative selection decisions. As a case study, prioritization of six lumber treatment alternatives [micronized copper quaternary (MCQ); alkaline copper quaternary (ACQ); water-borne copper naphthenate (CN); oil-borne copper naphthenate (CNo); water-borne copper quinolate (CQ); and water-borne zinc naphthenate (ZN)] for military use are considered. Multiattribute value theory (MAVT) is used to derive risk and benefit scores. Risk scores are calculated using a cradle-to-gate LCA. Benefit scores are calculated by scoring of cost, durability, and corrosiveness criteria. Three weighting schemes are used, representing Environmental, Military and Balanced stakeholder perspectives. Aggregated scores from all three perspectives show CQ to be the least favorable alterative. MCQ is identified as the most favorable alternative from the Environmental stakeholder perspective. From the Military stakeholder perspective, ZN is determined to be the most favorable alternative, followed closely by MCQ. This type of scoring and ranking of multiple heterogeneous criteria in a systematic and transparent way facilitates better justification of technology selection and regulation. C1 [Tsang, Michael P.; Bates, Matthew E.; Linkov, Igor] US Army Engineer Res & Dev Ctr, Environm Lab, Concord, MA 01742 USA. [Madison, Marcus] US Army Corps Engineers, Concord, MA 01742 USA. RP Linkov, I (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, 696 Virginia Rd, Concord, MA 01742 USA. EM igor.linkov@usace.army.mil FU U.S. Army Corps of Engineers FX The present work benefited from the input of Stan Lebow of the U.S. Forest Products Laboratory. The authors are grateful to Cate Fox-Lent for paper review and discussions. The U.S. Army Corps of Engineers funded the research described here. NR 34 TC 3 Z9 4 U1 4 U2 26 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD OCT 7 PY 2014 VL 48 IS 19 BP 11543 EP 11550 DI 10.1021/es501996s PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AQ7RJ UT WOS:000343016600066 PM 25209330 ER PT J AU Ramakrishnan, S Laxminarayan, S Wesensten, NJ Kamimori, GH Balkin, TJ Reitman, J AF Ramakrishnan, Sridhar Laxminarayan, Srinivas Wesensten, Nancy J. Kamimori, Gary H. Balkin, Thomas J. Reitman, Jaques TI Dose-dependent model of caffeine effects on human vigilance during total sleep deprivation SO JOURNAL OF THEORETICAL BIOLOGY LA English DT Article DE Caffeine model; Dose dependency; Individualized model; Pharmacokinetic-pharmacodynamic model; Cross-study validation ID INDIVIDUALIZED PERFORMANCE PREDICTION; NORMAL HEALTHY-VOLUNTEERS; DEPRIVED INDIVIDUALS; 2-PROCESS MODEL; CHEWING GUM; PHARMACOKINETICS; MODAFINIL; ALERTNESS; TASK; DEXTROAMPHETAMINE AB Caffeine is the most widely consumed stimulant to counter sleep-loss effects. While the pharmacokinetics of caffeine in the body is well-understood, its alertness-restoring effects are still not well characterized. In fact, mathematical models capable of predicting the effects of varying doses of caffeine on objective measures of vigilance are not available. In this paper, we describe a phenomenological model of the dose-dependent effects of caffeine on psychomotor vigilance task (PVT) performance of sleep-deprived subjects. We used the two-process model of sleep regulation to quantify performance during sleep loss in the absence of caffeine and a dose-dependent multiplier factor derived from the Hill equation to model the effects of single and repeated caffeine doses. We developed and validated the model fits and predictions on PVT lapse (number of reaction times exceeding 500 ms) data from two separate laboratory studies. At the population-average level, the model captured the effects of a range of caffeine doses (50-300 mg), yielding up to a 90% improvement over the two-process model. Individual-specific caffeine models, on average, predicted the effects up to 23% better than population-average caffeine models. The proposed model serves as a useful tool for predicting the dose-dependent effects of caffeine on the PVT performance of sleep-deprived subjects and, therefore, can be used for determining caffeine doses that optimize the timing and duration of peak performance. Published by Elsevier Ltd. C1 [Ramakrishnan, Sridhar; Laxminarayan, Srinivas; Reitman, Jaques] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, DoD Biotechnol High Performance Comp Software App, Ft Detrick, MD 21702 USA. [Wesensten, Nancy J.; Kamimori, Gary H.; Balkin, Thomas J.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD 20910 USA. RP Reitman, J (reprint author), US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, DoD Biotechnol High Performance Comp Software App, 504 Scott St, Ft Detrick, MD 21702 USA. EM jaques.reifman.civ@mail.mil FU Military Operational Medicine Research Area Directorate of the U.S. Army Medical Research and Materiel Command, Ft. Detrick, MD; U.S. Department of Defense Medical Research and Development Program [DMRDP_13200] FX This work was sponsored by the Military Operational Medicine Research Area Directorate of the U.S. Army Medical Research and Materiel Command, Ft. Detrick, MD, and by the U.S. Department of Defense Medical Research and Development Program (Grant No. DMRDP_13200). NR 41 TC 4 Z9 4 U1 1 U2 65 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0022-5193 EI 1095-8541 J9 J THEOR BIOL JI J. Theor. Biol. PD OCT 7 PY 2014 VL 358 BP 11 EP 24 DI 10.1016/j.jtbi.2014.05.017 PG 14 WC Biology; Mathematical & Computational Biology SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational Biology GA AN1IV UT WOS:000340336900002 PM 24859426 ER PT J AU Ehrenberg, PK Geretz, A Baldwin, KM Apps, R Polonis, VR Robb, ML Kim, JH Michael, NL Thomas, R AF Ehrenberg, Philip K. Geretz, Aviva Baldwin, Karen M. Apps, Richard Polonis, Victoria R. Robb, Merlin L. Kim, Jerome H. Michael, Nelson L. Thomas, Rasmi TI High-throughput multiplex HLA genotyping by next-generation sequencing using multi-locus individual tagging SO BMC GENOMICS LA English DT Article DE HLA; NGS; HLA typing; Illumina MiSeq ID HIGH-RESOLUTION; IMMUNOLOGICAL SYNAPSE; CLASS-I; TRANSPLANTATION; EXPRESSION; LOCI; POPULATION; MARROW; SYSTEM; LEVEL AB Background: Unambiguous human leukocyte antigen (HLA) typing is important in transplant matching and disease association studies. High-resolution HLA typing that is not restricted to the peptide-binding region can decrease HLA allele ambiguities. Cost and technology constraints have hampered high-throughput and efficient high resolution unambiguous HLA typing. We have developed a method for HLA genotyping that preserves the very high-resolution that can be obtained by next-generation sequencing (NGS) but also achieves substantially increased efficiency. Unambiguous HLA-A, B, C and DRB1 genotypes can be determined for 96 individuals in a single run of the Illumina MiSeq. Results: Long-range amplification of full-length HLA genes from four loci was performed in separate polymerase chain reactions (PCR) using primers and PCR conditions that were optimized to reduce co-amplification of other HLA loci. Amplicons from the four HLA loci of each individual were then pooled and subjected to enzymatic library generation. All four loci of an individual were then tagged with one unique index combination. This multi-locus individual tagging (MIT) method combined with NGS enabled the four loci of 96 individuals to be analyzed in a single 500 cycle sequencing paired-end run of the Illumina-MiSeq. The MIT-NGS method generated sequence reads from the four loci were then discriminated using commercially available NGS HLA typing software. Comparison of the MIT-NGS with Sanger sequence-based HLA typing methods showed that all the ambiguities and discordances between the two methods were due to the accuracy of the MIT-NGS method. Conclusions: The MIT-NGS method enabled accurate, robust and cost effective simultaneous analyses of four HLA loci per sample and produced 6 or 8-digit high-resolution unambiguous phased HLA typing data from 96 individuals in a single NGS run. C1 [Ehrenberg, Philip K.; Geretz, Aviva; Baldwin, Karen M.; Polonis, Victoria R.; Robb, Merlin L.; Kim, Jerome H.; Michael, Nelson L.; Thomas, Rasmi] US Mil HIV Res Program MHRP, Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Geretz, Aviva; Baldwin, Karen M.; Robb, Merlin L.; Thomas, Rasmi] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Apps, Richard] LEIDOS Inc, Frederick Natl Lab Canc Res, Frederick, MD USA. RP Thomas, R (reprint author), US Mil HIV Res Program MHRP, Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM rthomas@hivresearch.org FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DOD) [W81XWH-07-2-0067]; U.S. National Institute of Allergy and Infectious Disease FX This work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD). This research was funded, in part, by the U.S. National Institute of Allergy and Infectious Disease. The views expressed are those of the authors and should not be construed to represent the positions of the U.S. Army or the DOD. We would like to thank Dr. Yuko Yukhi from the National Cancer Institute in Frederick for assistance with the HLA-DRB1 SBT protocol and Sebastian Molnar, Mary Bryson and Kara Lombardi for PBMC separation. We thank Tim Hague, Omixon for helpful comments. NR 27 TC 14 Z9 15 U1 4 U2 15 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2164 J9 BMC GENOMICS JI BMC Genomics PD OCT 6 PY 2014 VL 15 AR 864 DI 10.1186/1471-2164-15-864 PG 8 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA AQ9MT UT WOS:000343179600003 PM 25283548 ER PT J AU Lapovok, R Gao, X Nie, JF Estrin, Y Mathaudhu, SN AF Lapovok, Rimma Gao, Xiang Nie, Jian-Feng Estrin, Yuri Mathaudhu, Suveen N. TI Enhancement of properties in cast Mg-Y-Zn rod processed by severe plastic deformation SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Mg-Y-Zn alloys; LPSO phases; Severe plastic deformation; Equal channel angular pressing; High pressure torsion ID ALLOYS; MICROSTRUCTURE; STRENGTH; PRECIPITATION; PRESSURE; PHASES; RE AB Ternary Mg-Y-Zn alloys have attracted considerable attention from researchers due to their excellent mechanical properties and unique microstructures, particularly from the presence of long-period stacking-order (LPSO) phases. Microstructural variations and the resulting mechanical properties can be affected by various processing routes, particularly those involving severe plastic deformation of a cast billet. The approach used in this work was based on subjecting cast Mg92Y4Zn4 (composition in wt%) billet to severe plastic deformation by three different routes, namely equal channel angular pressing (ECAP), high pressure torsion (HPT) and ECAP followed by HPT, with the aim of refining the microstructure and improving mechanical properties. Samples processed by ECAP were annealed by post-processing and tested in compression and tension. The effect of the processing route and the process parameters on the microstructure and the hardness of the Mg-Y-Zn alloy is reported. An overall positive effect of annealing treatment on the mechanical properties of ECAP-processed alloy is demonstrated. (C) 2014 Elsevier B.V. All rights reserved. C1 [Lapovok, Rimma; Gao, Xiang; Nie, Jian-Feng; Estrin, Yuri] Monash Univ, Dept Mat Engn, Clayton, Vic 3800, Australia. [Mathaudhu, Suveen N.] US Army, Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. RP Lapovok, R (reprint author), Monash Univ, Dept Mat Engn, Clayton, Vic 3800, Australia. EM rimma.lapovok@monash.edu RI Mathaudhu, Suveen/B-4192-2009 FU U.S. Army International Technology Center - Pacific; US Army Research Laboratory [FA5209-11-T-0043] FX This project was supported by the U.S. Army International Technology Center - Pacific and the US Army Research Laboratory (FA5209-11-T-0043), under programme managers Dr. Christopher Drew and Dr. Vincent Hammond, respectively. NR 23 TC 9 Z9 9 U1 7 U2 42 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 EI 1873-4936 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD OCT 6 PY 2014 VL 615 BP 198 EP 207 DI 10.1016/j.msea.2014.07.068 PG 10 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA AR1HN UT WOS:000343336400025 ER PT J AU Strawhecker, KE Cole, DP AF Strawhecker, Kenneth E. Cole, Daniel P. TI Morphological and Local Mechanical Surface Characterization of Ballistic Fibers via AFM SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article DE fibers; mechanical properties; morphology; properties and characterization; structure-property relations ID MOLECULAR-WEIGHT POLYETHYLENE; ARAMID FIBERS; ELASTIC-MODULUS; COMPRESSION; MODEL AB As-received morphologies, defect structures, and contact moduli of Kevlar KM2 Plus and three other ballistic fibers varying in chemistry and processing, were observed and compared using atomic force microscopy (AFM) and instrumented nanoindentation (NI) techniques. Surface features and defects were defined and measured for each fiber chemistry: p-phenylene terephthalamides (PPTA including KM2 Plus and Twaron), co-polymer aramid (AuTx), and ultra high molecular weight polyethylene (UHMWPE including Dyneema). Although a multitude of surface defects were observed in each fiber, the types of defects were similar from one fiber type to another. It was found that surface defects generally map to a more compliant local modulus value. Contact modulus values were compared with NI elastic modulus values to demonstrate validity for the AFM technique. Challenges and limitations of the AFM technique for cataloging defects are discussed. This study is the first which attempts to outline the various morphologies found on several fiber surfaces. These local property studies will enable future comparisons with single filament and bulk fiber properties. (C) 2014 Wiley Periodicals, Inc. C1 [Strawhecker, Kenneth E.] US Army Res Lab, RDRL WMM G, Aberdeen Proving Ground, MD 21005 USA. [Cole, Daniel P.] US Army Res Lab, RDRL VTM, Aberdeen Proving Ground, MD 21005 USA. RP Strawhecker, KE (reprint author), US Army Res Lab, RDRL WMM G, Aberdeen Proving Ground, MD 21005 USA. EM kenneth.e.strawhecker.civ@mail.mil FU ARL [NNL09AA00A] FX The authors acknowledge Stephanie Marcott, Erica Ford, Christopher Drew and Ramanathan Nagarajan of Natick Soldier Research, Development & Engineering Center for providing the fibers used in this study. KES gratefully acknowledges helpful discussions with Eric Wetzel at ARL and also discussions with Quinn P. McAllister. DPC is a contractor to ARL under contract NNL09AA00A. NR 36 TC 7 Z9 7 U1 3 U2 57 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0021-8995 EI 1097-4628 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD OCT 5 PY 2014 VL 131 IS 19 AR 40880 DI 10.1002/app.40880 PG 12 WC Polymer Science SC Polymer Science GA AM9YV UT WOS:000340238300067 ER PT J AU Shreiber, D Cravey, R Cole, MW AF Shreiber, D. Cravey, R. Cole, M. W. TI Numerical Simulations of a Metamaterial Based on an Array of Complex Oxide Thin Film Infinite Rods for THz Applications SO FERROELECTRICS LA English DT Article DE Complex oxide thin films; THz dielectric metamaterials AB Tunability of ferroelectric complex oxides is achieved by applied bias voltage. Many applications require usage of relatively low voltage which is achievable by using a ferroelectric thin-film. Recently developed dielectric metamaterials were implemented in bulk and in thick films. Metamaterials are resonant structures. The frequency range of 0.1-1.5 THz is of special interest for such applications as non-destructive evaluation of materials and detection of chemical and biological hazards. This paper numerically investigates the possibility of a resonant effect in a thin-film ferroelectric metamaterial and the effects of increased dielectric constant and thickness on the thin-film's resonance frequency. C1 [Shreiber, D.; Cole, M. W.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Cravey, R.] NASA, Electromagnet & Sensors Branch, Langley Res Ctr, Hampton, VA 23681 USA. RP Shreiber, D (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM daniel.shreiber.ctr@mail.mil NR 9 TC 0 Z9 0 U1 3 U2 12 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0015-0193 EI 1563-5112 J9 FERROELECTRICS JI Ferroelectrics PD OCT 3 PY 2014 VL 470 IS 1 SI SI BP 28 EP 34 DI 10.1080/00150193.2014.922781 PG 7 WC Materials Science, Multidisciplinary; Physics, Condensed Matter SC Materials Science; Physics GA AR1BV UT WOS:000343316400008 ER PT J AU Cole, MW AF Cole, M. W. TI Temperature Stabilization of BST Thin Films: A Critical Review SO FERROELECTRICS LA English DT Article DE BST; temperature stable; tunable materials; materials design ID BARIUM-STRONTIUM-TITANATE; TUNABLE MICROWAVE APPLICATIONS; COMPOSITIONALLY GRADED (BA; PULSED-LASER DEPOSITION; DIELECTRIC-PROPERTIES; DEVICE APPLICATIONS; EPITAXIAL-GROWTH; PHASE SHIFTERS; BUFFER LAYER; TUNABILITY AB A review of the temperature stability issues associated with BaxSr1-xTiO3 (BST) thin films and a summary of innovative materials designs, and novel process science solutions which serve to help mitigate this temperature sensitivity is presented. The experimental results from the literature and from our own work are reviewed; the correspondence between the theoretical results and the measured properties of tunable materials is critically analyzed; and reasons for discrepancy between literature results are discussed. Particular emphasis is concentrated on tunable phase shifters and filters to enable phased array antennas, radars and other advanced communications devices. This critical review provides the foundation to spawn new materials research solutions to further enable the development of BST films for microwave device applications. C1 US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Cole, MW (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM Melanie.w.cole.civ@mail.mil NR 43 TC 0 Z9 0 U1 5 U2 24 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0015-0193 EI 1563-5112 J9 FERROELECTRICS JI Ferroelectrics PD OCT 3 PY 2014 VL 470 IS 1 SI SI BP 67 EP 89 DI 10.1080/00150193.2014.922827 PG 23 WC Materials Science, Multidisciplinary; Physics, Condensed Matter SC Materials Science; Physics GA AR1BV UT WOS:000343316400013 ER PT J AU Lee, A Khiabanian, H Kugelman, J Elliott, O Nagle, E Yu, GY Warren, T Palacios, G Rabadan, R AF Lee, Albert Khiabanian, Hossein Kugelman, Jeffrey Elliott, Oliver Nagle, Elyse Yu, Guo-Yun Warren, Travis Palacios, Gustavo Rabadan, Raul TI Transcriptome reconstruction and annotation of cynomolgus and African green monkey SO BMC GENOMICS LA English DT Article DE Cynomolgus macaque; Macaca fascicularis; African green monkey; Chlorocebus aethiops; RNA-seq; Transcriptome; Genomics; Annotation; Database ID RNA-SEQ EXPERIMENTS; GENE-EXPRESSION; MACACA-FASCICULARIS; DIFFERENTIAL GENE; NONHUMAN-PRIMATES; HUMAN GENOME; IDENTIFICATION; EVOLUTION; SEQUENCE; DATABASE AB Background: Non-human primates (NHPs) and humans share major biological mechanisms, functions, and responses due to their close evolutionary relationship and, as such, provide ideal animal models to study human diseases. RNA expression in NHPs provides specific signatures that are informative of disease mechanisms and therapeutic modes of action. Unlike the human transcriptome, the transcriptomes of major NHP animal models are yet to be comprehensively annotated. Results: In this manuscript, employing deep RNA sequencing of seven tissue samples, we characterize the transcriptomes of two commonly used NHP animal models: Cynomolgus macaque (Macaca fascicularis) and African green monkey (Chlorocebus aethiops). We present the Multi-Species Annotation (MSA) pipeline that leverages well-annotated primate species and annotates 99.8% of reconstructed transcripts. We elucidate tissue-specific expression profiles and report 13 experimentally validated novel transcripts in these NHP animal models. Conclusion: We report comprehensively annotated transcriptomes of two non-human primates, which we have made publically available on a customized UCSC Genome Browser interface. The MSA pipeline is also freely available. C1 [Lee, Albert; Khiabanian, Hossein; Elliott, Oliver; Rabadan, Raul] Columbia Univ Coll Phys & Surg, Dept Biomed Informat, New York, NY 10032 USA. [Lee, Albert; Khiabanian, Hossein; Elliott, Oliver; Rabadan, Raul] Columbia Univ Coll Phys & Surg, Dept Syst Biol, New York, NY 10032 USA. [Kugelman, Jeffrey; Nagle, Elyse; Yu, Guo-Yun; Palacios, Gustavo] US Army, Med Res Inst Infect Dis, Genom Div, Ft Detrick, MD 21702 USA. [Warren, Travis] US Army, Med Res Inst Infect Dis, Mol Sci Div, Ft Detrick, MD 21702 USA. [Warren, Travis] US Army, Med Res Inst Infect Dis, Translat Sci Div, Ft Detrick, MD 21702 USA. [Palacios, Gustavo] George Mason Univ, Natl Ctr Biodef & Infect Dis, Manassas, VA 20110 USA. RP Rabadan, R (reprint author), Columbia Univ Coll Phys & Surg, Dept Biomed Informat, 630 W 168th St, New York, NY 10032 USA. EM rabadan@c2b2.columbia.edu RI Palacios, Gustavo/I-7773-2015; OI Palacios, Gustavo/0000-0001-5062-1938; Khiabanian, Hossein/0000-0003-1446-4394 FU Defense Threat Reduction Agency (DTRA) [W81XWH-13-2-0029] FX We thank Jiguang Wang for his invaluable help and comments on the manuscript. We also thank Pedro Rico and Carl Soffler for assisting with sample acquisition. This work was funded by the Defense Threat Reduction Agency (DTRA) grant W81XWH-13-2-0029. NR 40 TC 2 Z9 2 U1 1 U2 9 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2164 J9 BMC GENOMICS JI BMC Genomics PD OCT 3 PY 2014 VL 15 AR 846 DI 10.1186/1471-2164-15-846 PG 11 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA AQ3NQ UT WOS:000342701200001 PM 25277458 ER PT J AU Thames, K AF Thames, Knox TI PAKISTAN'S DANGEROUS GAME WITH RELIGIOUS EXTREMISM SO REVIEW OF FAITH & INTERNATIONAL AFFAIRS LA English DT Article C1 [Thames, Knox] US Commiss Int Religious Freedom, Washington, DC 20002 USA. [Thames, Knox] US Army War Coll, Carlisle, PA USA. RP Thames, K (reprint author), US Commiss Int Religious Freedom, Washington, DC 20002 USA. NR 37 TC 0 Z9 0 U1 0 U2 1 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1557-0274 EI 1931-7743 J9 REV FAITH INT AFF JI Rev. Faith Int. Aff. PD OCT 2 PY 2014 VL 12 IS 4 BP 40 EP 48 DI 10.1080/15570274.2014.977021 PG 9 WC Religion SC Religion GA AU4ZJ UT WOS:000345616500004 ER PT J AU Stieh, DJ King, DF Klein, K Liu, P Shen, X Hwang, KK Ferrari, G Montefiori, DC Haynes, B Pitisuttithum, P Kaewkungwal, J Nitayaphan, S Rerks-Ngarm, S Michael, NL Robb, ML Kim, JH Denny, TN Tomaras, GD Shattock, RJ AF Stieh, Daniel J. King, Deborah F. Klein, Katja Liu, Pinghuang Shen, Xiaoying Hwang, Kwan Ki Ferrari, Guido Montefiori, David C. Haynes, Barton Pitisuttithum, Punnee Kaewkungwal, Jaranit Nitayaphan, Sorachai Rerks-Ngarm, Supachai Michael, Nelson L. Robb, Merlin L. Kim, Jerome H. Denny, Thomas N. Tomaras, Georgia D. Shattock, Robin J. TI Aggregate complexes of HIV-1 induced by multimeric antibodies SO RETROVIROLOGY LA English DT Article DE HIV-1; Mucosal immunity; Immunoglobulin A; Aggregation ID VACCINE EFFICACY TRIAL; IGA SUBCLASSES; VIRION CAPTURE; NEUTRALIZATION; INFECTION; RV144; INHIBITION; IMMUNITY; GP120; IMMUNOGENICITY AB Background: Antibody mediated viral aggregation may impede viral transfer across mucosal surfaces by hindering viral movement in mucus, preventing transcytosis, or reducing inter-cellular penetration of epithelia thereby limiting access to susceptible mucosal CD4 T cells and dendritic cells. These functions may work together to provide effective immune exclusion of virus from mucosal tissue; however little is known about the antibody characteristics required to induce HIV aggregation. Such knowledge may be critical to the design of successful immunization strategies to facilitate viral immune exclusion at the mucosal portals of entry. Results: The potential of neutralizing and non-neutralizing IgG and IgA monoclonals (mAbs) to induce HIV-1 aggregation was assessed by Dynamic light scattering (DLS). Although neutralizing and non-neutralizing IgG mAbs and polyclonal HIV-Ig efficiently aggregated soluble Env trimers, they were not capable of forming viral aggregates. In contrast, dimeric (but not monomeric) IgA mAbs induced stable viral aggregate populations that could be separated from uncomplexed virions. Epitope specificity influenced both the degree of aggregation and formation of higher order complexes by dIgA. IgA purified from serum of uninfected RV144 vaccine trial responders were able to efficiently opsonize viral particles in the absence of significant aggregation, reflective of monomeric IgA. Conclusions: These results collectively demonstrate that dIgA is capable of forming stable viral aggregates providing a plausible basis for testing the effectiveness of aggregation as a potential protection mechanism at the mucosal portals of viral entry. C1 [Stieh, Daniel J.] St Georges Univ London, Ctr Infect, Dept Cellular & Mol Med, London SW17 0RE, England. [King, Deborah F.; Klein, Katja; Shattock, Robin J.] Univ London Imperial Coll Sci Technol & Med, Infect Dis Sect, Mucosal Infect & Immun Grp, London W2 1PG, England. [Liu, Pinghuang; Shen, Xiaoying; Hwang, Kwan Ki; Ferrari, Guido; Montefiori, David C.; Haynes, Barton; Denny, Thomas N.; Tomaras, Georgia D.] Duke Univ, Med Ctr, Duke Human Vaccine Ctr, Durham, NC 27710 USA. [Pitisuttithum, Punnee; Kaewkungwal, Jaranit] Fac Trop Med, Mahidol, Thailand. [Nitayaphan, Sorachai] Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Bangkok, Thailand. [Michael, Nelson L.; Robb, Merlin L.; Kim, Jerome H.] Walter Reed Army Inst Res, Mil HIV Res Program, Silver Spring, MD USA. RP Shattock, RJ (reprint author), Univ London Imperial Coll Sci Technol & Med, Infect Dis Sect, Mucosal Infect & Immun Grp, St Marys Campus, London W2 1PG, England. EM r.shattock@imperial.ac.uk RI Ferrari, Guido/A-6088-2015; Tomaras, Georgia/J-5041-2016 FU National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Division of AIDS (DAIDS), U.S. Department of Health and Human Services (HHS); Center for HIV/AIDS Vaccine Immunology (CHAVI) [U19 AI067854-05]; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery [UM1-AI100645-01]; Bill and Melinda Gates Foundation [1033098, 1040758]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DOD) [W81XWH-07-2-0067]; U.S. National Institute of Allergy and Infectious Diseases; Dormeur Investment Service Ltd FX The authors acknowledge the generosity of Dietmar Katinger (Polymune, Scientific, Vienna, Austria) for providing monoclonal antibodies. We thank D. Burton for supplying various b12 antibodies. We thank Guido Ferrari and David Montefiori for providing ADCC and neutralization data, respectively. We thank Christina Ochsenbauer and John Kappes for infectious molecular clones. Research in this publication was supported by the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Division of AIDS (DAIDS), U.S. Department of Health and Human Services (HHS), the Center for HIV/AIDS Vaccine Immunology (CHAVI) # U19 AI067854-05, the Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, grant number UM1-AI100645-01, Bill and Melinda Gates Foundation Grants 1033098 and 1040758, and a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD). This research was funded, in part, by the U.S. National Institute of Allergy and Infectious Diseases. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the U.S. Army or the Department of Defense. We gratefully acknowledge an equipment grant from Dormeur Investment Service Ltd that provided funding to purchase of equipment used in these studies. We are indebted to the volunteers and clinical staff who participated in the RV144 vaccine trial. We thank Charla Andrews for clinical trial project management and Kelly Soderberg for study management for the RV144 studies. NR 46 TC 7 Z9 7 U1 0 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PD OCT 2 PY 2014 VL 11 AR 78 DI 10.1186/s12977-014-0078-8 PG 16 WC Virology SC Virology GA AS8OC UT WOS:000344506900001 PM 25274446 ER PT J AU Tollefson, E Goldsman, D Kleywegt, A Tovey, C AF Tollefson, Eric Goldsman, David Kleywegt, Anton Tovey, Craig TI Optimal Selection of the Most Probable Multinomial Alternative SO SEQUENTIAL ANALYSIS-DESIGN METHODS AND APPLICATIONS LA English DT Article DE Indifference zone; Integer programming; Linear programming; Multinomial selection; Ranking; Selection; 60C05; 60G40; 62F07; 62F35; 62L10; 62L15; 90C05; 90C10 ID SOBEL SEQUENTIAL PROCEDURE; LARGEST PROBABILITY; HIGHEST PROBABILITY; EVENT; BECHHOFER; KIEFER; TRUNCATION AB Multinomial selection is concerned with selecting the most probable (best) multinomial alternative. The alternatives compete in a number of independent trials. In each trial, each alternative wins with an unknown probability specific to that alternative. A long-standing research goal has been to find a procedure that minimizes the expected number of trials subject to a lower bound on the probability of correct selection (P(CS)). Numerous procedures have been proposed over the past 55 years, all of them suboptimal, for the version where the number of trials is bounded. We achieve the goal in the following sense: For a given multinomial probability vector, lower bound on P(CS), and upper bound on trials, we use linear programming (LP) to construct a procedure that is guaranteed to minimize the expected number of trials. This optimal procedure may necessarily be randomized. We also present a mixed-integer linear program (MIP) that produces an optimal deterministic procedure. In our computational studies, the MIP always outperforms previously existing methods from the literature, with a modest additional benefit arising from the LP's randomized procedure. C1 [Tollefson, Eric] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. [Goldsman, David; Kleywegt, Anton; Tovey, Craig] Georgia Inst Technol, Sch ISyE, Atlanta, GA 30332 USA. RP Goldsman, D (reprint author), Georgia Tech, Sch ISyE, Atlanta, GA 30332 USA. EM sman@gatech.edu FU National Science Foundation [CMMI-0927592, CMMI-1233141] FX The second author was supported by National Science Foundation grants CMMI-0927592 and CMMI-1233141. NR 18 TC 2 Z9 2 U1 0 U2 1 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0747-4946 EI 1532-4176 J9 SEQUENTIAL ANAL JI Seq. Anal. PD OCT 2 PY 2014 VL 33 IS 4 BP 491 EP 508 DI 10.1080/07474946.2014.961848 PG 18 WC Statistics & Probability SC Mathematics GA AR2JG UT WOS:000343409700005 ER PT J AU Dickerson, K Gaston, JR AF Dickerson, Kelly Gaston, Jeremy R. TI Did you hear that? The role of stimulus similarity and uncertainty in auditory change deafness SO FRONTIERS IN PSYCHOLOGY LA English DT Review DE change deafness; similarity effects; uncertainty; informational masking; environmental sound perception; complex sound perception ID INFORMATIONAL MASKING; ENVIRONMENTAL SOUNDS; PERCEPTION; SCENES; REPRESENTATIONS; ATTENTION; BLINDNESS; MEMORY; EAR AB Change deafness, the auditory analog to change blindness, occurs when salient, and behaviorally relevant changes to sound sources are missed. Missing significant changes in the environment can have serious consequences, however, this effect, has remained little more than a lab phenomenon and a party trick. It is only recently that researchers have begun to explore the nature of these profound errors in change perception. Despite a wealth of examples of the change blindness phenomenon, work on change deafness remains fairly limited. The purpose of the current paper is to review the state of the literature on change deafness and propose an explanation of change deafness that relies on factors related to stimulus information rather than attentional or memory limits. To achieve this, work on across several auditory research domains, including environmental sound classification, informational masking, and change deafness are synthesized to present a unified perspective on the perception of change errors in complex, dynamic sound environments. We hope to extend previous research by describing how it may be possible to predict specific patters of change perception errors based on varying degrees of similarity in stimulus features and uncertainty about which stimuli and features are important for a given perceptual decision. C1 [Dickerson, Kelly; Gaston, Jeremy R.] US Army, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Dickerson, K (reprint author), US Army, Dept Army, Res Lab, ATTN RDRL HRS, Aberdeen Proving Ground, MD 21005 USA. EM kdicker1@binghamton.edu NR 42 TC 4 Z9 4 U1 2 U2 18 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1664-1078 J9 FRONT PSYCHOL JI Front. Psychol. PD OCT 2 PY 2014 VL 5 AR 1125 DI 10.3389/fpsyg.2014.01125 PG 5 WC Psychology, Multidisciplinary SC Psychology GA AQ3IS UT WOS:000342686000002 PM 25324821 ER PT J AU Qiu, XG Wong, G Audet, J Bello, A Fernando, L Alimonti, JB Fausther-Bovendo, H Wei, HY Aviles, J Hiatt, E Johnson, A Morton, J Swope, K Bohorov, O Bohorova, N Goodman, C Kim, D Pauly, MH Velasco, J Pettitt, J Olinger, GG Whaley, K Xu, BL Strong, JE Zeitlin, L Kobinger, GP AF Qiu, Xiangguo Wong, Gary Audet, Jonathan Bello, Alexander Fernando, Lisa Alimonti, Judie B. Fausther-Bovendo, Hugues Wei, Haiyan Aviles, Jenna Hiatt, Ernie Johnson, Ashley Morton, Josh Swope, Kelsi Bohorov, Ognian Bohorova, Natasha Goodman, Charles Kim, Do Pauly, Michael H. Velasco, Jesus Pettitt, James Olinger, Gene G. Whaley, Kevin Xu, Bianli Strong, James E. Zeitlin, Larry Kobinger, Gary P. TI Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp SO NATURE LA English DT Article ID MONOCLONAL-ANTIBODIES; HEMORRHAGIC-FEVER; POSTEXPOSURE PROTECTION; MEDIATED PROTECTION; GUINEA-PIGS; INFECTION; CHALLENGE AB Without an approved vaccine or treatments, Ebola outbreak management has been limited to palliative care and barrier methods to prevent transmission. These approaches, however, have yet to end the 2014 outbreak of Ebola after its prolonged presence in West Africa. Here we show that a combination of monoclonal antibodies (ZMapp), optimized from two previous antibody cocktails, is able to rescue 100% of rhesus macaques when treatment is initiated up to 5 days post-challenge. High fever, viraemia and abnormalities in blood count and blood chemistry were evident in many animals before ZMapp intervention. Advanced disease, as indicated by elevated liver enzymes, mucosal haemorrhages and generalized petechia could be reversed, leading to full recovery. ELISA and neutralizing antibody assays indicate that ZMapp is cross-reactive with the Guinean variant of Ebola. ZMapp exceeds the efficacy of any other therapeutics described so far, and results warrant further development of this cocktail for clinical use. C1 [Qiu, Xiangguo; Wong, Gary; Audet, Jonathan; Bello, Alexander; Fernando, Lisa; Alimonti, Judie B.; Fausther-Bovendo, Hugues; Wei, Haiyan; Aviles, Jenna; Strong, James E.; Kobinger, Gary P.] Publ Hlth Agcy Canada, Natl Lab Zoonot Dis & Special Pathogens, Winnipeg, MB R3E 3R2, Canada. [Wong, Gary; Audet, Jonathan; Bello, Alexander; Fausther-Bovendo, Hugues; Strong, James E.; Kobinger, Gary P.] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB R3E 0J9, Canada. [Wei, Haiyan; Xu, Bianli] Henan Ctr Dis Control & Prevent, Inst Infect Dis, Zhengzhou 450012, Henan, Peoples R China. [Hiatt, Ernie; Johnson, Ashley; Morton, Josh; Swope, Kelsi] Kentucky BioProc, Owensboro, KY 42301 USA. [Bohorov, Ognian; Bohorova, Natasha; Goodman, Charles; Kim, Do; Pauly, Michael H.; Velasco, Jesus; Whaley, Kevin; Zeitlin, Larry] Mapp Biopharmaceut Inc, San Diego, CA 92121 USA. [Pettitt, James; Olinger, Gene G.] US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Strong, James E.] Univ Manitoba, Dept Pediat & Child Hlth, Winnipeg, MB R3A 1S1, Canada. [Kobinger, Gary P.] Univ Manitoba, Dept Immunol, Winnipeg, MB R3E 0T5, Canada. [Kobinger, Gary P.] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA. RP Zeitlin, L (reprint author), Mapp Biopharmaceut Inc, San Diego, CA 92121 USA. EM larry.zeitlin@mappbio.com; gary.kobinger@phac-aspc.gc.ca OI Audet, Jonathan/0000-0002-0743-7489 FU Defense Threat Reduction Agency (DTRA) [HDTRA1-13-C-0018]; National Institutes of Health [U19AI109762]; Public Health Agency of Canada (PHAC); Canadian Safety and Security Program (CSSP); Canadian Institute for Health Research (CIHR) FX The authors thank K. Tierney, A. Grolla, S. Jones, J. Dong and D. Kobasa for their technical assistance, V. Klimyuk and Y. Gleba for access to the magnICON expression system, and H. Steinkellner for access to transgenic N. benthamiana. This work was supported by the Defense Threat Reduction Agency (DTRA contract HDTRA1-13-C-0018), the National Institutes of Health (U19AI109762), the Public Health Agency of Canada (PHAC), and a Canadian Safety and Security Program (CSSP) grant to G. P. K. and X. Q. G. W. is the recipient of a Doctoral Research Award from the Canadian Institute for Health Research (CIHR). NR 33 TC 282 Z9 305 U1 30 U2 316 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0028-0836 EI 1476-4687 J9 NATURE JI Nature PD OCT 2 PY 2014 VL 514 IS 7520 BP 47 EP + DI 10.1038/nature13777 PG 15 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AP9SS UT WOS:000342420800032 PM 25171469 ER PT J AU Moretti, JD Harbol, SM Riegner, DE Carlucci, N Sabatini, JJ Poret, JC AF Moretti, Jared D. Harbol, Seth M. Riegner, Dawn E. Carlucci, Nicholas Sabatini, Jesse J. Poret, Jay C. TI Single-Point-of-Failure Mitigation: Prove-Out of a Green Light-Emitting Illuminant Composition in the Handheld Signal Cluster and 40-mm Parachute Configurations SO JOURNAL OF ENERGETIC MATERIALS LA English DT Article DE binders; energetic materials; green light emission; illuminants; pyrotechnics ID CIVILIAN APPLICATIONS; PERCHLORATE-FREE; MILITARY AB The development of handheld signal cluster and 40-mm parachute green light-emitting pyrotechnic compositions is described. Of the new compositions evaluated, one was found to exceed the military requirements in burn time, luminous intensity, dominant wavelength, and spectral purity in both the cluster and parachute configurations. The new illuminant composition is not plagued by single-point-of-failure concerns, as the Laminac 4116/Lupersol binder system has been replaced by the widely available Epon 813/Versamid 140 binder system. In addition, the new illuminant composition was found to be insensitive toward impact, friction, and electrostatic discharge and had a high thermal onset temperature. C1 [Moretti, Jared D.; Carlucci, Nicholas; Sabatini, Jesse J.; Poret, Jay C.] US Army RDECOM ARDEC, Pyrotech Technol & Prototyping Div, Picatinny Arsenal, NJ 07806 USA. [Harbol, Seth M.; Riegner, Dawn E.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. RP Moretti, JD (reprint author), US Army RDECOM ARDEC, Pyrotech Technol & Prototyping Div, Bldg 3124, Picatinny Arsenal, NJ 07806 USA. EM jared.d.moretti.civ@mail.mil FU U.S. Army (Picatinny Arsenal, NJ) FX The authors thank the U.S. Army (Picatinny Arsenal, NJ) for the funding of this work. NR 11 TC 2 Z9 2 U1 0 U2 12 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 520 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0737-0652 EI 1545-8822 J9 J ENERG MATER JI J. Energ. Mater. PD OCT 2 PY 2014 VL 32 IS 4 BP 293 EP 299 DI 10.1080/07370652.2013.866993 PG 7 WC Chemistry, Applied; Chemistry, Physical; Engineering, Chemical; Materials Science, Multidisciplinary SC Chemistry; Engineering; Materials Science GA AE4LL UT WOS:000333953800006 ER PT J AU O'Donnell, MT AF O'Donnell, Mary Teresa TI Use of ergonomic analysis to optimize lower cost training platforms for the Fundamentals of Laparoscopic Surgery SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Meeting Abstract CT 100th Annual Clinical Congress of the American-College-of-Surgeons CY OCT 26-30, 2014 CL San Francisco, CA SP Amer Coll Surg C1 [O'Donnell, Mary Teresa] Walter Reed Army Med Ctr, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 EI 1879-1190 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD OCT PY 2014 VL 219 IS 4 SU S BP E89 EP E89 PG 1 WC Surgery SC Surgery GA CR1UU UT WOS:000361111400206 ER PT J AU Challa, R Shoji, Y Conrads, KA Hood, BL Wang, GS Darcy, KM Hamilton, CA Maxwell, GL Conrads, TP Risinger, JI AF Challa, Rusheeswar Shoji, Yutaka Conrads, Kelly A. Hood, Brian L. Wang, Guisong Darcy, Kathleen M. Hamilton, Chad A. Maxwell, George Larry Conrads, Thomas P. Risinger, John I. TI Metastasis suppressor CD82/KAI1 expression is dependent on functional SWI/SNF ARID1A/B SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Challa, Rusheeswar; Shoji, Yutaka; Risinger, John I.] Michigan State Univ, Grand Rapids, MI USA. [Conrads, Kelly A.; Hood, Brian L.; Wang, Guisong; Darcy, Kathleen M.; Maxwell, George Larry; Conrads, Thomas P.] Inova Hlth Syst, Womens Hlth Integrated Res Ctr, Annandale, VA USA. [Hamilton, Chad A.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 990 DI 10.1158/1538-7445.AM2014-990 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906905458 ER PT J AU Shoji, Y Conrads, KA Challa, R Hood, BL Wang, GS Darcy, KM Hamilton, CA Maxwell, GL Conrads, TP Risinger, JI AF Shoji, Yutaka Conrads, Kelly A. Challa, Rusheeswar Hood, Brian L. Wang, Guisong Darcy, Kathleen M. Hamilton, Chad A. Maxwell, George Larry Conrads, Thomas P. Risinger, John I. TI ARID1A regulation of ATAD2 in gynecologic cancer SO CANCER RESEARCH LA English DT Meeting Abstract CT 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) CY APR 05-09, 2014 CL San Diego, CA SP Amer Assoc Canc Res C1 [Shoji, Yutaka; Challa, Rusheeswar; Risinger, John I.] Michigan State Univ, Grand Rapids, MI USA. [Conrads, Kelly A.; Hood, Brian L.; Wang, Guisong; Darcy, Kathleen M.; Maxwell, George Larry; Conrads, Thomas P.] Inova Hlth Syst, Womens Hlth Integrated Res Ctr, Annandale, VA USA. [Hamilton, Chad A.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD OCT 1 PY 2014 VL 74 IS 19 SU S MA 1570 DI 10.1158/1538-7445.AM2014-1570 PG 1 WC Oncology SC Oncology GA CB8UN UT WOS:000349906901295 ER PT J AU Wesensten, NJ AF Wesensten, Nancy J. TI Legitimacy of concerns about caffeine and energy drink consumption SO NUTRITION REVIEWS LA English DT Review DE alertness; caffeine; circadian rhythm; energy drinks; sleep ID SLEEP-DEPRIVATION; COLLEGE-STUDENTS; CHRONIC INSOMNIA; PERFORMANCE; RISK; MODAFINIL; ALERTNESS; US; SENSITIVITY; STIMULANTS AB Whether caffeine and energy drink consumption presents a critical emerging health problem is not currently known. Available evidence suggests that energy drink consumption represents a change in the ways in which individuals in the United States consume caffeine but that the amount of caffeine consumed daily has not appreciably increased. In the present review, the question of whether Americans are sleep deprived (a potential reason for using caffeine) is briefly explored. Reported rates of daily caffeine consumption (based on beverage formulation) and data obtained from both civilian and military populations in the United States are examined, the efficacy of ingredients other than caffeine in energy drinks is discussed, and the safety and side effects of caffeine are addressed, including whether evidence supports the contention that excessive caffeine/energy drink consumption induces risky behavior. The available evidence suggests that the main legitimate concern regarding caffeine and energy drink use is the potential negative impact on sleep but that, otherwise, there is no cause for concern regarding caffeine use in the general population. Published 2014. This article is a U.S. Government work and is in the public domain in the USA. C1 Walter Reed Army Inst Res, Behav Biol Branch, Silver Spring, MD 20910 USA. RP Wesensten, NJ (reprint author), Walter Reed Army Inst Res, Behav Biol Branch, Room 2A-26,503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Nancy.j.wesensten.civ@mail.mil FU United States Army Medical Research; Materiel Command Military Operational Medicine Research Program Directors FX The author acknowledges the United States Army Medical Research and Materiel Command Military Operational Medicine Research Program Directors for financial and scientific support of the ideas presented in this article. NR 58 TC 6 Z9 6 U1 8 U2 36 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0029-6643 EI 1753-4887 J9 NUTR REV JI Nutr. Rev. PD OCT PY 2014 VL 72 SU 1 SI SI BP 78 EP 86 DI 10.1111/nure.12146 PG 9 WC Nutrition & Dietetics SC Nutrition & Dietetics GA CB9PR UT WOS:000349964500010 PM 25293547 ER PT J AU McCoy, JR Mendoza, JM Spik, KW Badger, C Gomez, AF Schmaljohn, CS Sardesai, NY Broderick, KE AF McCoy, Jay R. Mendoza, Janess M. Spik, Kristin W. Badger, Catherine Gomez, Alan F. Schmaljohn, Connie S. Sardesai, Niranjan Y. Broderick, Kate E. TI A multi-head intradermal electroporation device allows for tailored and increased dose DNA vaccine delivery to the skin SO HUMAN VACCINES & IMMUNOTHERAPEUTICS LA English DT Article DE electroporation; dermal; noninvasive; tolerable; multi-agent; DNA vaccine ID IN-VIVO; IMMUNE-RESPONSES; NEUTRALIZING ANTIBODY; NONHUMAN-PRIMATES; CODON USAGE; VIRUS; IMMUNOGENICITY; CHALLENGE; MODEL; IMMUNIZATION AB The identification of an effective and tolerable delivery method is a necessity for the success of DNA vaccines in the clinic. This manuscript describes the development and validation of a multi-headed intradermal electroporation device which would be applicable for delivering multiple DNA vaccine plasmids simultaneously but spatially separated.Reporter gene plasmids expressing green and red fluorescent proteins were used to demonstrate the impact of spatial separation on DNA delivery to increase the number of transfected cells and avoid interference through visible expression patterns. To investigate the impact of plasmid interference on immunogenicity, a disease target was investigated where issues with multi-valent vaccines had been previously described. DNA-based Hantaan and Puumala virus vaccines were delivered separately or as a combination and the effect of multi-valence was determined by appropriate assays. While a negative impact was observed for both antigenic vaccines when delivered together, these effects were mitigated when the vaccine was delivered using the multi-head device. We also demonstrate how the multi-head device facilitates higher dose delivery to the skin resulting in improved immune responses.This new multi-head platform device is an efficient, tolerable and non-invasive method to deliver multiple plasmid DNA constructs simultaneously allowing the tailoring of delivery sites for combination vaccines. Additionally, this device would allow the delivery of multi-plasmid vaccine formulations without risk of impacted immune responses through interference. Such a low-cost, easy to use device platform for the delivery of multi-agent DNA vaccines would have direct applications by the military and healthcare sectors for mass vaccination purposes. C1 [McCoy, Jay R.; Mendoza, Janess M.; Gomez, Alan F.; Sardesai, Niranjan Y.; Broderick, Kate E.] Inovio Pharmaceut Inc, Plymouth Meeting, PA 19422 USA. [Spik, Kristin W.; Badger, Catherine; Schmaljohn, Connie S.] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. RP Broderick, KE (reprint author), Inovio Pharmaceut Inc, Plymouth Meeting, PA 19422 USA. EM kbroderick@inovio.com RI bebarta, vikhyat/K-3476-2015 FU Department of Defense SBIR grant [W81XWH-11-C0051] FX This work was supported in part by a Department of Defense SBIR grant (Phase I and Phase II) number W81XWH-11-C0051. NR 41 TC 1 Z9 1 U1 0 U2 1 PU LANDES BIOSCIENCE PI AUSTIN PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA SN 2164-5515 EI 2164-554X J9 HUM VACC IMMUNOTHER JI Human Vaccines Immunother. PD OCT PY 2014 VL 10 IS 10 BP 3039 EP 3047 DI 10.4161/hv.29671 PG 9 WC Biotechnology & Applied Microbiology; Immunology SC Biotechnology & Applied Microbiology; Immunology GA AZ6FX UT WOS:000348315500044 PM 25483486 ER PT J AU Ivler, CM Powell, JD Tischler, MB Fletcher, JW Ott, C AF Ivler, Christina M. Powell, J. David Tischler, Mark B. Fletcher, Jay W. Ott, Carl TI Design and Flight Test of a Cable Angle Feedback Flight Control System for the RASCAL JUH-60 Helicopter SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB The ability of a helicopter to carry externally slung loads makes it very versatile for many civil and military operations. However, the piloted handling qualities of the helicopter are degraded by the presence of the slung load. A control system is developed that uses measurements of the slung load motions as well as conventional fuselage feedback to improve the handling qualities for hover/low-speed operations. Prior research has shown a fundamental trade-off between load damping and piloted handling qualities for a feedback control system with cable angle/rate feedback. A new task-tailored approach proposed and implemented herein uses a method of switching between a load damping mode and a piloted handling qualities mode. These modes provide appropriate load feedback depending on the piloting task and flight regime. This provides improved handling qualities for maneuvering flight and for improved precision load control at hover. A new mission task element for precision load placement is developed (for possible inclusion into ADS-33E-PRF) to test the ability of the cable feedback system to improve load placement task performance. The improvements provided by this control system are demonstrated in a piloted flight test on the JUH-60A RASCAL fly-by-wire helicopter. The average load set-down time was reduced by a factor of two for the 1000-lb load on a 56-ft sling. C1 [Ivler, Christina M.] US Army RDECOM, Aviat Dev Directorate AFDD AMRDEC, Moffett Field, CA 94035 USA. [Powell, J. David] Stanford Univ, Dept Aeronaut & Astronaut, Stanford, CA 94305 USA. [Tischler, Mark B.; Fletcher, Jay W.; Ott, Carl] US Army RDECOM, Aviat Dev Directorate AFDD AMRDEC, Ames Res Ctr, Moffett Field, CA USA. RP Ivler, CM (reprint author), US Army RDECOM, Aviat Dev Directorate AFDD AMRDEC, Moffett Field, CA 94035 USA. EM christina.ivler@us.army.mil NR 23 TC 2 Z9 2 U1 0 U2 0 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 EI 2161-6027 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD OCT PY 2014 VL 59 IS 4 AR 042008 DI 10.4050/JAHS.59.042008 PG 15 WC Engineering, Aerospace SC Engineering GA AZ7YT UT WOS:000348432300009 ER PT J AU Mettler, B Kong, ZD Goerzen, C Whalley, M AF Mettler, Berenice Kong, Zhaodan Goerzen, Chad Whalley, Matthew TI Guidance Performance Benchmarking for Autonomous Rotorcraft SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB This paper describes a framework for performance evaluation of autonomous guidance systems. The elements of the framework consist of a set of spatial geometries, flight tasks, performance metrics, a flightdynamic model, and baseline solutions. The spatial benchmarks consist of six tasks in simple geometrical environments and 10 tasks inmore complex urban environments based on a real digital terrain elevation map. The framework also includes a set of performance metrics used to compare trajectories. The performance baselines used in the proposed framework are near-optimal solutions computed using one of two trajectory optimization methods: numerical optimization based on nonlinear programming for the simple geometric environments and a motion primitive automaton for problems involving the urban environments. The paper concludes with a demonstration of the benchmarking framework using the Obstacle Field Navigation system developed by the Army Aeroflightdynamics Directorate. C1 [Mettler, Berenice; Kong, Zhaodan] Univ Minnesota, Dept Aerosp Engn & Mech, Interact Guidance & Control Lab, Minneapolis, MN 55455 USA. [Goerzen, Chad] San Jose State Univ, Res Fdn, Ames Res Ctr, Moffett Field, CA USA. [Whalley, Matthew] US Army Res, Aeroflightdynam Directorate AMRDEC, Dev Engn Command Ames Res Ctr, Moffett Field, CA USA. RP Mettler, B (reprint author), Univ Minnesota, Dept Aerosp Engn & Mech, Interact Guidance & Control Lab, Minneapolis, MN 55455 USA. EM mettler@umn.edu RI Kong, Zhaodan/E-9362-2015 OI Kong, Zhaodan/0000-0002-2493-1366 FU NASA Ames [NNX07AN31A] FX This research work was enabled thanks to the financial support of NASA Ames (grant number NNX07AN31A). NR 25 TC 0 Z9 0 U1 0 U2 2 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 EI 2161-6027 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD OCT PY 2014 VL 59 IS 4 AR 042009 DI 10.4050/JAHS.59.042009 PG 16 WC Engineering, Aerospace SC Engineering GA AZ7YT UT WOS:000348432300010 ER PT J AU Raz, R Rosen, A Cicolani, LS Lusardi, J AF Raz, Reuben Rosen, Aviv Cicolani, Luigi S. Lusardi, Jeffery TI Using Wind Tunnel Tests for Slung-Load Clearance, Part 1: The CONEX Cargo Container SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB Previously, the authors showed that dynamic wind tunnel tests of a suspended CONEX cargo container model exhibited encouraging levels of success in predicting the stability characteristics and speed envelope of the full-scale load. The present study includes further use of the UH-60/CONEX system to investigate effects that were observed previously, but not fully addressed. These effects include the influence of pilot inputs and helicopter motions on the coupled pilot/helicopter/slung-load dynamics, the influence of center of gravity offset of the slung load, and the behavior of a load when a yaw swivel is not used in the suspension. It is shown that all three effects are important and affect the slung-load dynamics. The capability of wind tunnel tests to predict the behavior of slung loads in flight is shown for these effects. C1 [Raz, Reuben; Rosen, Aviv] Technion Israel Inst Technol, Fac Aerosp Engn, IL-32000 Haifa, Israel. [Cicolani, Luigi S.] San Jose State Univ, Res Fdn, San Jose, CA 95192 USA. [Cicolani, Luigi S.] NASA, Ames Res Ctr, Moffett Field, CA 94035 USA. [Lusardi, Jeffery] US Army, Aviat Dev Directorate, AFDD Aviat & Missile Res, Dev & Engn Ctr Res,Ames Res Ctr, Moffett Field, CA USA. RP Rosen, A (reprint author), Technion Israel Inst Technol, Fac Aerosp Engn, IL-32000 Haifa, Israel. EM rosen@aerodyne.technion.ac.il NR 18 TC 3 Z9 3 U1 1 U2 1 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 EI 2161-6027 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD OCT PY 2014 VL 59 IS 4 AR 042003 DI 10.4050/JAHS.59.042003 PG 12 WC Engineering, Aerospace SC Engineering GA AZ7YT UT WOS:000348432300004 ER PT J AU Raz, R Rosen, A Cicolani, LS Lusardi, J Gassaway, B Thompson, T AF Raz, Reuben Rosen, Aviv Cicolani, Luigi S. Lusardi, Jeffery Gassaway, Bryan Thompson, Tom TI Using Wind Tunnel Tests for Slung-Load Clearance, Part 2: Other Loads SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB The first new load is the TRIO container that can be flown in three configurations with different heights. The second new load is a ribbon bridge interior bay section. Wind tunnel results with models of the new loads exhibit in general good agreement with flight-test results. The results of the new loads strengthen further the approach of using wind tunnel tests to accelerate slung-load clearance, as well as reduce risk and cost. C1 [Raz, Reuben; Rosen, Aviv] Technion Israel Inst Technol, Fac Aerosp Engn, IL-32000 Haifa, Israel. [Cicolani, Luigi S.] San Jose State Univ, Res Fdn, San Jose, CA 95192 USA. [Lusardi, Jeffery] US Army, Aviat Dev Directorate, AFDD Aviat & Missile Res, Dev & Engn Ctr Res,Ames Res Ctr, Moffett Field, CA USA. [Gassaway, Bryan; Thompson, Tom] US Army, Aviat Engn Directorate, Aeromech Div, Redstone Arsenal, AL USA. RP Rosen, A (reprint author), Technion Israel Inst Technol, Fac Aerosp Engn, IL-32000 Haifa, Israel. EM rosen@aerodyne.technion.ac.il NR 10 TC 2 Z9 2 U1 1 U2 2 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 EI 2161-6027 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD OCT PY 2014 VL 59 IS 4 AR 042004 DI 10.4050/JAHS.59.042004 PG 12 WC Engineering, Aerospace SC Engineering GA AZ7YT UT WOS:000348432300005 ER PT J AU Genovese, RF Johnson, CC Tobin, CA Gauchan, S AF Genovese, Raymond F. Johnson, Christina C. Tobin, Christine A. Gauchan, Sangeeta TI Multiple presentations reduce the behavioral impact of protected predator exposure in rats SO BEHAVIOURAL PROCESSES LA English DT Article DE Stress; Predator exposure; PTSD; Elevated plus maze; Activity; Fear; Rat ID ELEVATED PLUS-MAZE; ANIMAL-MODEL; FERRET ODOR; STRESS; EXPRESSION; ANXIETY; PCREB; CORTICOSTERONE; HIPPOCAMPUS; IMPAIRMENT AB Exposure of rats to a predator species, such as a cat, or stimuli associated with a predator species has been used to model the effects of traumatic stress. We further investigated this procedure to determine if the behavioral effects from such exposure could be increased by multiple exposures. In rats (n = 8 for each treatment group), we evaluated single (1 x) and multiple (1x/day for 3 consecutive days [3 x] and 2 x/day for 3 consecutive days [6x]) exposures using cats and soiled cat litter. All exposures were 15 min in duration and the rats were directly exposed to the cats but in a protected fashion that did not allow the predator to physically injure the rat. Sham exposures were conducted using similar conditions without the presence of the predator or litter. The effects of the exposures were evaluated using an elevated plus maze (EPM). Sessions on the EPM were conducted before the exposures and at various times after the exposure. Difference scores (post-pre) were calculated for dependent measures from the EPM, and statistical analyses compared the slopes and intercept values derived from regression functions from these scores over the post-exposure sessions. During the first 30 days after exposure, a significant reduction in activity on the EPM was observed for the lx treatment and a smaller reduction was observed for the 3x treatment, but no reduction was observed for the 6 x and sham control treatments. Thus, increasing the number of exposures did not increase the magnitude of the effect but, instead, resulted in a decrease. These results show that adaptation to the effects of the predator exposure occurred with repeated sessions. (C) 2014 Elsevier B.V. All rights reserved. C1 [Genovese, Raymond F.; Johnson, Christina C.; Tobin, Christine A.; Gauchan, Sangeeta] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Behav Biol Branch, Silver Spring, MD 20910 USA. RP Genovese, RF (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Behav Biol Branch, Silver Spring, MD 20910 USA. EM Raymond.F.Genovese.Civ@mail.mil FU U.S. Army Medical Research and Materiel Command FX The authors thank Stefania Dobre, MAJ Crystal Bean, Christina LaValle, Dr. Nicole L.T. Moore, Marcia A. Caputo and LTC Julie Stephens-DeValle for helpful contributions to the studies. This research was supported by the Military Operational Medicine Research Program, U.S. Army Medical Research and Materiel Command. NR 28 TC 1 Z9 1 U1 3 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0376-6357 EI 1872-8308 J9 BEHAV PROCESS JI Behav. Processes PD OCT PY 2014 VL 108 BP 105 EP 109 DI 10.1016/j.beproc.2014.09.032 PG 5 WC Psychology, Biological; Behavioral Sciences; Zoology SC Psychology; Behavioral Sciences; Zoology GA AY5GB UT WOS:000347599800016 PM 25280946 ER PT J AU Akapirat, S Karnasuta, C Madnote, S Savadsuk, H Puangkaew, J Rittiroongrad, S Vasan, S Ngauy, V Robb, ML Excler, JL Pitisutthithum, P Rerks-Ngarm, S Michael, NL de Souza, MS Kim, JH O'Connell, RJ Karasavvas, N AF Akapirat, Siriwat Karnasuta, Chitraporn Madnote, Sirinan Savadsuk, Hathairat Puangkaew, Jiraporn Rittiroongrad, Surawach Vasan, Sandhya Ngauy, Viseth Robb, Merlin L. Excler, Jean-Louis Pitisutthithum, Punnee Rerks-Ngarm, Supachai Michael, Nelson L. de Souza, Mark S. Kim, Jerome H. O'Connell, Robert J. Karasavvas, Nicos CA Rv305 Study Grp TI HIV-specific Antibody in Rectal Secretions Following Late Boosts in RV144 Participants (RV305) SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Akapirat, Siriwat; Karnasuta, Chitraporn; Madnote, Sirinan; Savadsuk, Hathairat; Puangkaew, Jiraporn; Rittiroongrad, Surawach; Vasan, Sandhya; Ngauy, Viseth; O'Connell, Robert J.; Karasavvas, Nicos] Armed Forces Res Inst Med Sci, Dept Retrovirol, Bangkok 10400, Thailand. [Robb, Merlin L.; Excler, Jean-Louis] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Robb, Merlin L.; Excler, Jean-Louis; Michael, Nelson L.; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Pitisutthithum, Punnee] Mahidol Univ, Fac Trop Med, Bangkok, Thailand. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand. [de Souza, Mark S.] Cooper Human Syst, Nashua, NH USA. [de Souza, Mark S.] Natl Inst Infect Dis, AIDS Res Ctr, Tokyo, Japan. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA OA11.05 BP A33 EP A33 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774400066 ER PT J AU Ake, J Ratto-Kim, S Schuetz, A Wieczorek, L Nguay, V Kibuuka, H Sawe, F Maboko, L Polonis, V Weiner, D DeSouza, M Sekiziyivu, A Kosgei, J Missanga, M Kroidl, A Earl, P Moss, B Adams, E Martinez, A Rizvi, F Khan, A Sardesai, N Michael, N Marovich, M Robb, M AF Ake, Julie Ratto-Kim, Silvia Schuetz, Alexandra Wieczorek, Lindsay Nguay, Viseth Kibuuka, Hannah Sawe, Fredrick Maboko, Leonard Polonis, Victoria Weiner, David DeSouza, Mark Sekiziyivu, Arthur Kosgei, Josphat Missanga, Marco Kroidl, Arne Earl, Patricia Moss, Bernard Adams, Elizabeth Martinez, Ana Rizvi, Farrukh Khan, Amir Sardesai, Niranjan Michael, Nelson Marovich, Mary Robb, Merlin CA RV 262 Study Grp TI Phase 1 Trial of the Safety and Immunogenicity of PENNVAX (R)-G DNA Prime Administered by Biojector (R) 2000 or CELLECTRA (R) EP Device with MVA-CMDR Boost SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Ake, Julie; Ratto-Kim, Silvia; Wieczorek, Lindsay; Nguay, Viseth; Polonis, Victoria; Michael, Nelson; Robb, Merlin] WRAIR, US Mil HIV Res Program, Silver Spring, MD USA. [Schuetz, Alexandra; DeSouza, Mark] Armed Forces Res Inst Med Sci, Dept Retrovirol, Bangkok 10400, Thailand. [Kibuuka, Hannah] Makerere Univ, Walter Reed Project, Kampala, Uganda. [Sawe, Fredrick; Kosgei, Josphat] KEMRI, Walter Reed Project, Kericho, Kenya. [Maboko, Leonard; Missanga, Marco; Kroidl, Arne] Mbeya Med Res Ctr, Mbeya, Tanzania. [Weiner, David] Univ Penn, Philadelphia, PA 19104 USA. [Kroidl, Arne] Univ Munich, Dept Infect Dis & Trop Med, Munich, Germany. [Earl, Patricia; Moss, Bernard] NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA. [Adams, Elizabeth; Martinez, Ana; Marovich, Mary] NIAID, Div Aids, NIH, Bethesda, MD 20892 USA. [Rizvi, Farrukh] Mil Infect Dis Res Program, Ft Detrick, MD USA. [Khan, Amir; Sardesai, Niranjan] Inovio Pharmaceut Inc, Blue Bell, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA P26.02 BP A186 EP A186 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774402109 ER PT J AU Eamsila, C Akapirat, S Nitayapan, S Rerks-Ngarm, S Pitisutthithum, P Vasan, S Excler, JL Karasavvas, N Ngauy, V Robb, ML Michael, NL Kim, JH O'Connell, RJ AF Eamsila, Chirapa Akapirat, Siriwat Nitayapan, Sorachai Rerks-Ngarm, Supachai Pitisutthithum, Punnee Vasan, Sandhya Excler, Jean-Louis Karasavvas, Nicos Ngauy, Viseth Robb, Merlin L. Michael, Nelson L. Kim, Jerome H. O'Connell, Robert J. TI Vaccine Induced Seroreactivity in RV144 Vaccine Recipients in RV305, a Placebo Controlled Assessment of Late Boosts with ALVAC-HIV and AIDSVAX B/E SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Eamsila, Chirapa; Akapirat, Siriwat; Nitayapan, Sorachai; Vasan, Sandhya; Karasavvas, Nicos; Ngauy, Viseth; O'Connell, Robert J.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nothaburi, Thailand. [Pitisutthithum, Punnee] Mahidol Univ, Fac Trop Med, Bangkok, Thailand. [Vasan, Sandhya; Excler, Jean-Louis; Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Robb, Merlin L.; Michael, Nelson L.; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA P26.13 BP A191 EP A191 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774402120 ER PT J AU Edlefsen, PT Rolland, M Hertz, T Tovanabutra, S Gartland, AJ deCamp, AC Magaret, CA Ahmed, H Gottardo, R Juraska, M McCoy, C Larsen, BB Sanders-Buell, E Carrico, C Menis, S Bose, M Arroyo, MA O'Connell, RJ deSouza, MS Nitayaphan, S Pitisuttithum, P Kaewkungwal, J Rerks-Ngarm, S Robb, ML McLellan, JS Georgiev, IS Kirys, T Kwong, PD Carlson, JM Michael, NL Schief, WR Mullins, JI Kim, JH Gilbert, PB AF Edlefsen, Paul T. Rolland, Morgane Hertz, Tomer Tovanabutra, Sodsai Gartland, Andrew J. deCamp, Allan C. Magaret, Craig A. Ahmed, Hasan Gottardo, Raphael Juraska, Michal McCoy, Connor Larsen, Brendan B. Sanders-Buell, Eric Carrico, Chris Menis, Sergey Bose, Meera Arroyo, Miguel A. O'Connell, Robert J. deSouza, Mark S. Nitayaphan, Sorachai Pitisuttithum, Punnee Kaewkungwal, Jaranit Rerks-Ngarm, Supachai Robb, Merlin L. McLellan, Jason S. Georgiev, Ivelin S. Kirys, Tatsiana Kwong, Peter D. Carlson, Jonathan M. Michael, Nelson L. Schief, William R. Mullins, James I. Kim, Jerome H. Gilbert, Peter B. CA RV144 Sequencing Team TI Comprehensive Sieve Analysis of Breakthrough HIV-1 Sequences in the RV144 Vaccine Efficacy Trial SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Edlefsen, Paul T.; Hertz, Tomer; Gartland, Andrew J.; deCamp, Allan C.; Magaret, Craig A.; Ahmed, Hasan; Gottardo, Raphael; Juraska, Michal; Gilbert, Peter B.] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USA. [Rolland, Morgane; Tovanabutra, Sodsai; Sanders-Buell, Eric; Bose, Meera; Robb, Merlin L.; Michael, Nelson L.; Kim, Jerome H.] US Mil HIV Res Program, Silver Spring, MD USA. [McCoy, Connor] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA. [Larsen, Brendan B.; Mullins, James I.] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA. [Carrico, Chris; Menis, Sergey; Schief, William R.] Univ Washington, Dept Biochem, Seattle, WA 98195 USA. [Carrico, Chris; Menis, Sergey; Schief, William R.] Scripps Res Inst, IAVI Neutralizing Antibody Ctr, La Jolla, CA 92037 USA. [Carrico, Chris; Menis, Sergey; Schief, William R.] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA. [Arroyo, Miguel A.; Nitayaphan, Sorachai; Kaewkungwal, Jaranit] Royal Thai Army Component, AFRIMS, Bangkok, Thailand. [O'Connell, Robert J.; deSouza, Mark S.] US Army Component, AFRIMS, Bangkok, Thailand. [Pitisuttithum, Punnee] Mahidol Univ, Fac Trop Med, Bangkok, Thailand. [Rerks-Ngarm, Supachai] Thai Minist Publ Hlth, Nonthaburi, Thailand. [McLellan, Jason S.; Georgiev, Ivelin S.; Kirys, Tatsiana; Kwong, Peter D.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. [Carlson, Jonathan M.] Microsoft Res, Redmond, WA USA. [Schief, William R.] Ragon Inst MGH MIT & Harvard, Cambridge, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA OA08.04 BP A25 EP A26 PG 4 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774400047 ER PT J AU Filali-Mouhim, A Fourati, S Lefebvre, F Thomas, R Gottardo, R Frahm, N De Rosa, S Wilkinson, P Stafova, P Sabnis, A Kaewkungwal, J Pitisuttithum, P Nitayanphan, S Rerks-Ngarm, S Michael, N Kim, J Robb, ML O'Connell, RJ McElrath, MJ Cameron, M Sekaly, R AF Filali-Mouhim, Ali Fourati, Slim Lefebvre, Francois Thomas, Rasmi Gottardo, Raphael Frahm, Nicole De Rosa, Stephen Wilkinson, Peter Stafova, Petra Sabnis, Amit Kaewkungwal, Jaranit Pitisuttithum, Punnee Nitayanphan, Sorachai Rerks-Ngarm, Supachai Michael, Nelson Kim, Jerome Robb, Merlin L. O'Connell, Robert J. McElrath, M. Juliana Cameron, Mark Sekaly, Rafick TI Integrated Systems Biology Analysis Reveals Contrasting Role for Innate Immune Response Genes in Conferring Risk of Infection in RV144 Trial SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Filali-Mouhim, Ali; Fourati, Slim; Lefebvre, Francois; Wilkinson, Peter; Stafova, Petra; Sabnis, Amit; Kaewkungwal, Jaranit; Cameron, Mark] Vaccine & Gene Therapy Inst Florida, Port St Lucie, FL USA. [Thomas, Rasmi; Kim, Jerome; Robb, Merlin L.] Walter Reed Army Inst Res, US Mil HIV Res Program MHRP, Bethesda, MD USA. [Gottardo, Raphael; Frahm, Nicole; De Rosa, Stephen; McElrath, M. Juliana] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USA. [Pitisuttithum, Punnee] Mahidol Univ, Fac Trop Med, Bangkok, Thailand. [Nitayanphan, Sorachai] Royal Thai Army, Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand. [Michael, Nelson] Walter Reed Army Inst Res, US Mil HIV Res Program, Bethesda, MD USA. [O'Connell, Robert J.] Armed Forces Res Inst Med Sci, US Army Med Component, Bangkok 10400, Thailand. [Sekaly, Rafick] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA. RI Fourati, Slim/B-2756-2016 NR 0 TC 1 Z9 1 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA OA04.05 LB BP A15 EP A16 PG 5 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774400024 ER PT J AU Fourati, S Vaccari, M Gordon, SN Schifanella, L Cameron, M Keele, BF Shen, XY Tomoras, GD Billings, E Rao, M Chung, AW Dowell, K Bailey-Kellogg, C Brown, E Ackerman, ME Liyanage, NPM Vargas-Inchaistegui, DA Whitney, S Doster, MN Binello, N Pegu, P Montefiori, DC Foulds, K Quinn, DS Donaldson, M Liang, F Lore, K Roederer, M Koup, RA McDermott, A Ma, ZM Miller, CJ Phan, TB Forthal, DN Blackburn, M Caccuri, F Ferrari, G Thompson, D Robert-Guroff, M Ratto-Kim, S Kim, JH Michael, NL Phogat, S Barnett, SW Tartaglia, J Venzon, D Stablein, DM Alter, G Sekaly, RP Franchini, G AF Fourati, Slim Vaccari, Monica Gordon, Shari N. Schifanella, Luca Cameron, Mark Keele, Brandon F. Shen, Xiaoying Tomoras, Georgia D. Billings, Erik Rao, Mangala Chung, Amy W. Dowell, Karen Bailey-Kellogg, Chris Brown, Eric Ackerman, Margaret E. Liyanage, Namal P. M. Vargas-Inchaistegui, Diego A. Whitney, Stephen Doster, Melvin N. Binello, Nicolo Pegu, Poonam Montefiori, David C. Foulds, Kathryn Quinn, David S. Donaldson, Mitzi Liang, Frank Lore, Karin Roederer, Mario Koup, Richard A. McDermott, Adrian Ma, Zhong-Min Miller, Christopher J. Phan, Tran B. Forthal, Donald N. Blackburn, Matthew Caccuri, Francesca Ferrari, Guido Thompson, Devon Robert-Guroff, Marjorie Ratto-Kim, Silvia Kim, Jerome H. Michael, Nelson L. Phogat, Sanjay Barnett, Susan W. Tartaglia, James Venzon, David Stablein, Donald M. Alter, Galit Sekaly, Rafick-Pierre Franchini, Genoveffa TI Modulation of RAS Pathways as a Biomarker of Protection against HIV and as a Means to Improve Vaccine Efficacy SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Fourati, Slim; Cameron, Mark] Vaccine & Gene Therapy Inst Florida, Port St Lucie, FL USA. [Vaccari, Monica; Gordon, Shari N.; Schifanella, Luca; Liyanage, Namal P. M.; Doster, Melvin N.; Binello, Nicolo; Pegu, Poonam; Blackburn, Matthew; Caccuri, Francesca; Franchini, Genoveffa] NCI, Anim Models & Vaccine Sect, Bethesda, MD 20892 USA. [Keele, Brandon F.] NCI, AIDS & Canc Virus Program, Frederick, MD 21701 USA. [Shen, Xiaoying; Tomoras, Georgia D.] Duke Human Vaccine Inst, Durham, NC USA. [Billings, Erik; Rao, Mangala; Ratto-Kim, Silvia; Kim, Jerome H.; Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program MHRP, Silver Spring, MD USA. [Chung, Amy W.; Alter, Galit] Ragon Inst MGH MIT & Harvard, Boston, MA USA. [Dowell, Karen; Bailey-Kellogg, Chris] Dartmouth Coll, Hanover, NH 03755 USA. [Brown, Eric; Ackerman, Margaret E.] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. [Vargas-Inchaistegui, Diego A.; Robert-Guroff, Marjorie] NCI, Immune Biol Retroviral Infect Sect, Bethesda, MD 20892 USA. [Whitney, Stephen; Thompson, Devon] Adv BioSci Labs Inc, Rockville, MD USA. [Montefiori, David C.; Ferrari, Guido] Duke Univ, Med Ctr, Durham, NC USA. [Foulds, Kathryn; Liang, Frank; Lore, Karin; Roederer, Mario; Koup, Richard A.; McDermott, Adrian] NIH, Vaccine Res Ctr, Bethesda, MD 20892 USA. [Quinn, David S.; Donaldson, Mitzi] Karolinska Inst, Stockholm, Sweden. [Ma, Zhong-Min; Miller, Christopher J.] Univ Calif Davis, Calif Natl Primate Res Ctr, Davis, CA 95616 USA. [Phan, Tran B.; Forthal, Donald N.] Univ Calif Davis, Sch Med, Davis, CA 95616 USA. [Phogat, Sanjay; Tartaglia, James] Sanofi Pasteur, Swiftwater, PA USA. [Barnett, Susan W.] Novartis Vaccines & Diagnost Inc, Cambridge, MA USA. [Venzon, David] NCI, Biostat & Data Management Sect, Bethesda, MD 20892 USA. [Stablein, Donald M.] EMMES Corp, Rockville, MD USA. [Sekaly, Rafick-Pierre] Case Western Reserve Univ, Cleveland, OH 44106 USA. NR 0 TC 2 Z9 2 U1 0 U2 2 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA P03.04 LB BP A99 EP A99 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774401055 ER PT J AU Gray, GE Andersen-Nissen, E Grunenberg, N Huang, Y Roux, S Laher, F Innes, C Gu, NY DiazGranados, C Phogat, S Lee, C Swann, E Kim, J O'Connell, R Michael, N Flach, B DeRosa, S Frahm, N Morris, L Montefiori, D Gilbert, P Tomaras, G McElrath, J Corey, L AF Gray, Glenda E. Andersen-Nissen, Erica Grunenberg, Nicole Huang, Ying Roux, Surita Laher, Fatima Innes, Craig Gu, Niya DiazGranados, Carlos Phogat, Sanjay Lee, Carter Swann, Edith Kim, Jerome O'Connell, Robert Michael, Nelson Flach, Britta DeRosa, Steve Frahm, Nicole Morris, Lynn Montefiori, David Gilbert, Peter Tomaras, Georgia McElrath, Julie Corey, Lawrence CA HVTN 097 TI HVTN 097: Evaluation of the RV144 Vaccine Regimen in HIV Uninfected South African Adults SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Gray, Glenda E.] South African Med Res Council, Cape Town, South Africa. [Gray, Glenda E.] Perinatal & HIV Res Unit, Soweto, South Africa. [Andersen-Nissen, Erica; Flach, Britta; McElrath, Julie] Hutchinson Ctr Res Inst, Cape Town HVTN Immunol Lab, Cape Town, South Africa. [Grunenberg, Nicole; Corey, Lawrence] Fred Hutchinson Canc Res Ctr, HVTN, Seattle, WA 98104 USA. [Huang, Ying; Gilbert, Peter] Fred Hutchinson Canc Res Ctr, SCHARP, Seattle, WA 98104 USA. [Roux, Surita] Univ Cape Town, IIDMM, Desmond Tutu HIV Fdn, ZA-7925 Cape Town, South Africa. [Laher, Fatima] Univ Witwatersrand, Fac Hlth Sci, Perinatal HIV Res Unit, Soweto, South Africa. [Innes, Craig] Klerksdorp HVTN CRS, Aurum Inst Hlth Res, Klerksdorp, South Africa. [Gu, Niya; DiazGranados, Carlos; Phogat, Sanjay] Sanofi Pasteur, Swiftwater, PA USA. [Lee, Carter] Global Solut Infect Dis, San Francisco, CA USA. [Swann, Edith] NIAID, Div Aids, NIH, Bethesda, MD 20892 USA. [Kim, Jerome; O'Connell, Robert; Michael, Nelson] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [DeRosa, Steve; Frahm, Nicole; McElrath, Julie] Fred Hutchinson Canc Res Ctr, HVTN Lab Program, Seattle, WA 98104 USA. [Morris, Lynn] NHLS, Natl Inst Communicable Dis, Johannesburg, South Africa. [Montefiori, David; Tomaras, Georgia] Duke Univ, Human Vaccine Inst, Durham, NC USA. [Montefiori, David; Tomaras, Georgia] Duke Univ, Sch Med, Ctr HIV AIDS Vaccine Immunol, Durham, NC USA. RI Tomaras, Georgia/J-5041-2016 NR 0 TC 5 Z9 5 U1 5 U2 8 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA OA11.06 LB BP A33 EP A34 PG 4 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774400067 ER PT J AU Herrera, C Veazey, R Schuetz, A Olejniczak, N Chenine, AL Nitayaphan, S Kaewkungwal, J Pitisuttithum, P Rerks-Ngarm, S O'Connell, RJ Excler, JL Kim, JH Shattock, R AF Herrera, Carolina Veazey, Ronald Schuetz, Alexandra Olejniczak, Natalia Chenine, Agnes-Laurence Nitayaphan, Sorachai Kaewkungwal, Jaranit Pitisuttithum, Punnee Rerks-Ngarm, Supachai O'Connell, Robert J. Excler, Jean-Louis Kim, Jerome H. Shattock, Robin TI Evaluation of Mucosal Tissue Explants as Ex Vivo Surrogates of In Vivo Vaccination of Non-human Primates (NHPs) and Humans SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Herrera, Carolina; Olejniczak, Natalia; Shattock, Robin] Univ London Imperial Coll Sci Technol & Med, London, England. [Veazey, Ronald] Tulane Natl Primate Res Ctr, Tulane, LA USA. [Schuetz, Alexandra; Nitayaphan, Sorachai] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Chenine, Agnes-Laurence; O'Connell, Robert J.; Excler, Jean-Louis; Kim, Jerome H.] Walter Reed Army Inst Res, Rockville, MD USA. [Kaewkungwal, Jaranit; Pitisuttithum, Punnee] Mahidol Univ, Bangkok 10700, Thailand. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Bangkok, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA OA08.01 BP A24 EP A24 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774400044 ER PT J AU Hughes, L Hamm, T Khamadi, S Maganga, L Kibuuka, H Kiweewa, F Njoku, O Keshinro, B Maswai, J Aoko, A Omondi, M Otsyula, N Polyak, C Robb, M Michael, N Ake, J AF Hughes, Lindsay Hamm, Tiffany Khamadi, Samoel Maganga, Lucas Kibuuka, Hannah Kiweewa, Francis Njoku, Ogbonnaya Keshinro, Babajide Maswai, Jonah Aoko, Appolonia Omondi, Milton Otsyula, Nekoye Polyak, Christina Robb, Merlin Michael, Nelson Ake, Julie TI The Relationship between Stigma, Disclosure, and Adherence among Participants in the African Cohort Study SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Hughes, Lindsay; Hamm, Tiffany; Khamadi, Samoel; Kibuuka, Hannah; Kiweewa, Francis; Njoku, Ogbonnaya; Keshinro, Babajide; Maswai, Jonah; Aoko, Appolonia; Omondi, Milton; Otsyula, Nekoye; Polyak, Christina; Robb, Merlin; Michael, Nelson; Ake, Julie] Walter Reed Army Inst Res, US Mil HIV Res Program, Bethesda, MD USA. [Hughes, Lindsay; Hamm, Tiffany; Polyak, Christina; Robb, Merlin] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Khamadi, Samoel] Walter Reed Program Tanzania, Mbeya, Tanzania. [Maganga, Lucas] Natl Inst Med Res, Mbeya Med Res Ctr, Mbeya, Tanzania. [Kibuuka, Hannah; Kiweewa, Francis] Makerere Univ, Walter Reed Project, Kampala, Uganda. [Njoku, Ogbonnaya; Keshinro, Babajide] Walter Reed Program Nigeria, Abuja, Nigeria. [Maswai, Jonah; Aoko, Appolonia] Walter Reed Project Kenya, Kericho, Kenya. [Omondi, Milton; Otsyula, Nekoye] Walter Reed Project Kenya, Kisumu, Kenya. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA P23.02 BP A167 EP A167 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774402060 ER PT J AU Joachim, A Bauer, A Joseph, S Geldmacher, C Nilsson, C Munseri, P Missanga, M Mann, P Aboud, S Sudi, L Mviombo, P Haule, A Wahren, B Ferari, G Polonis, V Robb, M Tatoud, R Maboko, L Lyamuya, EF Hoelscher, M Bakari, M Biberfeldt, G Sandstrom, E Kroidl, A Mc Cormack, S AF Joachim, Agricola Bauer, Asli Joseph, Sarah Geldmacher, Christof Nilsson, Charlotta Munseri, Patricia Missanga, Marko Mann, Philip Aboud, Said Sudi, L. Mviombo, P. Haule, A. Wahren, Britta Ferari, Guido Polonis, Vicky Robb, Merlin Tatoud, Roger Maboko, Leonard Lyamuya, Eligius F. Hoelscher, Michael Bakari, Muhammad Biberfeldt, Gunnel Sandstrom, Eric Kroidl, Arne Mc Cormack, Sheena TI Immune Responses after Two Immunizations with rgp140/GLA Following Priming with HIV-DNA and HIV-MVA in Healthy Tanzanian Volunteers SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Joachim, Agricola; Munseri, Patricia; Aboud, Said; Lyamuya, Eligius F.; Bakari, Muhammad] Muhimbili Univ Hlth & Allied Sci, Dar Es Salaam, Tanzania. [Joachim, Agricola; Nilsson, Charlotta; Wahren, Britta; Biberfeldt, Gunnel] Karolinska Inst, Stockholm, Sweden. [Bauer, Asli; Missanga, Marko; Mann, Philip; Sudi, L.; Mviombo, P.; Haule, A.; Maboko, Leonard] NIMR Mbeya Med Res Ctr, Dar Es Salaam, Tanzania. [Bauer, Asli; Geldmacher, Christof; Mann, Philip; Hoelscher, Michael; Kroidl, Arne] Klinikum Univ Munich, Munich, Germany. [Joseph, Sarah; Mc Cormack, Sheena] UCL, MRC Clin Trials Unit, London, England. [Geldmacher, Christof; Hoelscher, Michael; Kroidl, Arne] German Ctr Infect Res, Munich, Germany. [Nilsson, Charlotta; Biberfeldt, Gunnel] Publ Hlth Agcy Sweden, Solna, Sweden. [Ferari, Guido] Duke Univ, Med Ctr, Durham, NC USA. [Polonis, Vicky] Walter Reed Army Inst Res, Silver Spring, MD USA. [Robb, Merlin] Henry M Jackson Fdn Adv Mil Med, Mil HIV Res Program, Bethesda, MD USA. [Tatoud, Roger] Univ London Imperial Coll Sci Technol & Med, London, England. [Sandstrom, Eric] Karolinska Inst, Sodersjukhuset, Venhalsan, Stockholm, Sweden. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA P26.08 BP A188 EP A189 PG 4 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774402115 ER PT J AU Kijak, GH Sanders-Buell, E Chenine, AL Eller, M Goonetilleke, N Thomas, R Leviyang, S Harbolick, E Bose, M Pham, P Oropeza, C Poltavee, K O'Sullivan, AM Merbah, M Costanzo, M Li, H Fischer, W Gao, F Eller, LA O'Connell, RJ Sinei, S Maganga, L Kibuuka, H Nitayaphan, S Rolland, M Korber, B McCutchan, F Shaw, G Michael, N Robb, M Tovanabutra, S Kim, J AF Kijak, Gustavo Hernan Sanders-Buell, Eric Chenine, Agnes-Laurance Eller, Michael Goonetilleke, Nilu Thomas, Rasmi Leviyang, Sivan Harbolick, Elizabeth Bose, Meera Phuc Pham Oropeza, Celina Poltavee, Kultida O'Sullivan, Anne Marie Merbah, Melanie Costanzo, Margaret Li, Hui Fischer, Will Gao, Feng Eller, Leigh Anne O'Connell, Robert J. Sinei, Samuel Maganga, Lucas Kibuuka, Hannah Nitayaphan, Sorachai Rolland, Morgane Korber, Bette McCutchan, Francine Shaw, George Michael, Nelson Robb, Merlin Tovanabutra, Sodsai Kim, Jerome TI Cryptic Multiple HIV-1 Infection Revealed by Early, Frequent, and Deep Sampling during Acute Infection SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Kijak, Gustavo Hernan; Sanders-Buell, Eric; Chenine, Agnes-Laurance; Eller, Michael; Thomas, Rasmi; Harbolick, Elizabeth; Bose, Meera; Phuc Pham; Oropeza, Celina; Poltavee, Kultida; O'Sullivan, Anne Marie; Merbah, Melanie; Costanzo, Margaret; Eller, Leigh Anne; Rolland, Morgane; Michael, Nelson; Robb, Merlin; Tovanabutra, Sodsai; Kim, Jerome] Walter Reed Army Inst Res, US Mil HIV Res Program MHRP, Silver Spring, MD USA. [Kijak, Gustavo Hernan; Sanders-Buell, Eric; Chenine, Agnes-Laurance; Eller, Michael; Thomas, Rasmi; Harbolick, Elizabeth; Bose, Meera; Phuc Pham; Oropeza, Celina; Poltavee, Kultida; O'Sullivan, Anne Marie; Merbah, Melanie; Costanzo, Margaret; Eller, Leigh Anne; Rolland, Morgane; Robb, Merlin; Tovanabutra, Sodsai] Henry M Jackson Fdn, US Mil HIV Res Program MHRP, Silver Spring, MD USA. [Goonetilleke, Nilu] Univ N Carolina, Sch Med, Chapel Hill, NC USA. [Leviyang, Sivan] Georgetown Univ, Dept Math & Stat, Washington, DC USA. [Li, Hui; Shaw, George] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA. [Fischer, Will; Korber, Bette] Los Alamos Natl Lab, Los Alamos, NM USA. [Gao, Feng] Duke Univ, Med Ctr, Duke Human Vaccine Inst, Durham, NC USA. [O'Connell, Robert J.; Nitayaphan, Sorachai] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Sinei, Samuel] Walter Reed Project, Kericho, Kenya. [Maganga, Lucas] Mbeya Med Res Programme, Mbeya, Tanzania. [Kibuuka, Hannah] Makerere Univ, Walter Reed Project, Kampala, Uganda. NR 0 TC 2 Z9 2 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA OA21.06 LB BP A58 EP A58 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774400127 ER PT J AU Nilsson, C Hejdeman, B Godoy-Ramirez, K Tecleab, T Scarlatti, G Brave, A Earl, PL Stout, RR Robb, ML Shattock, R Biberfeld, G Sandstrom, E Wahren, B AF Nilsson, Charlotta Hejdeman, Bo Godoy-Ramirez, Karina Tecleab, Teghesti Scarlatti, Gabriella Brave, Andreas Earl, Patricia L. Stout, Richard R. Robb, Merlin L. Shattock, Robin Biberfeld, Gunnel Sandstrom, Eric Wahren, Britta TI Intradermal HIV-DNA Given with or without Intradermal Electroporation Is Safe and Highly Immunogenic in Healthy Swedish HIV-1 DNA/MVA Vaccinees SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Nilsson, Charlotta; Godoy-Ramirez, Karina; Tecleab, Teghesti; Brave, Andreas; Biberfeld, Gunnel] Publ Hlth Agcy Sweden, Solna, Sweden. [Nilsson, Charlotta; Brave, Andreas; Biberfeld, Gunnel; Wahren, Britta] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden. [Nilsson, Charlotta] Karolinska Inst, Dept Lab Med, Huddinge, Sweden. [Hejdeman, Bo; Sandstrom, Eric] Sodersjukhuset, Venhalsan, Sweden. [Hejdeman, Bo; Sandstrom, Eric] Karolinska Inst, Venhalsan, Sweden. [Hejdeman, Bo; Sandstrom, Eric] Dept Educ & Clin Res, Stockholm, Sweden. [Scarlatti, Gabriella] IRCCS San Raffaele Sci Inst, Milan, Italy. [Earl, Patricia L.] NIAID, NIH, Bethesda, MD 20892 USA. [Stout, Richard R.] Bioject Inc, Tualatin, OR USA. [Robb, Merlin L.] Walter Reed Army Inst Res, Dept Retrovirol, Rockville, MD USA. [Shattock, Robin] Univ London Imperial Coll Sci Technol & Med, Dept Infect Dis, Div Med, London, England. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA OA11.02 BP A31 EP A32 PG 3 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774400063 ER PT J AU Pitisuttithum, P Nitayaphan, S Chariyalertsak, S Karasavvas, N Kaewkungwal, J Ngauy, V Vasan, S Robb, ML Michael, NL Brown, JK Andrews, C Phonrat, B Dhitavat, J Excler, JL Kim, JH O'Connell, RJ AF Pitisuttithum, Punnee Nitayaphan, Sorachai Chariyalertsak, Suwat Karasavvas, Nicos Kaewkungwal, Jaranit Ngauy, Viseth Vasan, Sandhya Robb, Merlin L. Michael, Nelson L. Brown, J. Kendall Andrews, Charla Phonrat, Benjaluck Dhitavat, Jittima Excler, Jean Louis Kim, Jerome H. O'Connell, Robert J. CA RV306 Study Team TI RV306, an Evaluation of a 48 Week ALVAC-HIV AIDSVAX B/E Vaccination Regimen in Thailand: Participation Rates for Optional Specimen Collections SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Pitisuttithum, Punnee; Phonrat, Benjaluck; Dhitavat, Jittima] Mahidol Univ, Fac Trop Med, Vaccine Trial Ctr, Bangkok, Thailand. [Nitayaphan, Sorachai] AFRIMS, Royal Thai Army Clin Res Ctr, Bangkok, Thailand. [Chariyalertsak, Suwat] Chiang Mai Univ, Res Inst Hlth Sci RIHES, Chiang Mai 50000, Thailand. [Karasavvas, Nicos; Ngauy, Viseth; Vasan, Sandhya; O'Connell, Robert J.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Kaewkungwal, Jaranit] BIOPHICS Ctr Excellence Biomed & Publ Hlth Inform, Bangkok, Thailand. [Robb, Merlin L.; Michael, Nelson L.; Brown, J. Kendall; Andrews, Charla; Excler, Jean Louis; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil HIV Res Program, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA P44.09 BP A264 EP A264 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774403134 ER PT J AU Prentice, H Geraghty, D Tomaras, GD Fong, YY Nelson, W Kijak, G Zolla-Pazner, S Nitayaphan, S Rerks-Ngarm, S Kaewkungwal, J Pitisuttithum, P Michael, NL Gilbert, P Kim, JH Thomas, R AF Prentice, Heather Geraghty, Daniel Tomaras, Georgia D. Fong, Youyi Nelson, Wyatt Kijak, Gustavo Zolla-Pazner, Susan Nitayaphan, Sorachai Rerks-Ngarm, Supachai Kaewkungwal, Jaranit Pitisuttithum, Punnee Michael, Nelson L. Gilbert, Peter Kim, Jerome H. Thomas, Rasmi TI Immune Correlates Identified in the RV144 Vaccine Efficacy Trial Impact HIV-1 Acquisition Only in the Presence of Certain HLA Class II Genes SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Prentice, Heather; Kijak, Gustavo; Michael, Nelson L.; Kim, Jerome H.; Thomas, Rasmi] Walter Reed Army Inst Res, US Mil HIV Res Program MHRP, Silver Spring, MD USA. [Prentice, Heather; Kijak, Gustavo; Thomas, Rasmi] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Geraghty, Daniel; Nelson, Wyatt] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA. [Tomaras, Georgia D.] Duke Univ, Sch Med, Human Vaccine Inst, Durham, NC USA. [Tomaras, Georgia D.] Duke Univ, Sch Med, Ctr HIV AIDS Vaccine Immunol, Durham, NC USA. [Fong, Youyi; Gilbert, Peter] Fred Hutchinson Canc Res Ctr, Stat Ctr HIV AIDS Res & Prevent, Vaccine & Infect Dis Div, Seattle, WA 98104 USA. [Zolla-Pazner, Susan] NYU, Sch Med, Vet Affairs New York Harbor Healthcare Syst, New York, MD USA. [Zolla-Pazner, Susan] NYU, Sch Med, Dept Pathol, New York, MD USA. [Nitayaphan, Sorachai] AFRIMS, Dept Retrovirol, US Army Med Component, Bangkok, Thailand. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand. [Kaewkungwal, Jaranit; Pitisuttithum, Punnee] Mahidol Univ, Ctr Excellence Biomed & Publ Hlth Informat BIOPHI, Bangkok 10700, Thailand. RI Tomaras, Georgia/J-5041-2016 NR 0 TC 0 Z9 0 U1 0 U2 2 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA OA14.03 BP A40 EP A40 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774400082 ER PT J AU Rutvisuttinunt, W Leelawiwat, W Chinnawirotpisan, P Mueanpai, F Kongpechsatit, O Klungthong, C O'Connell, R de Souza, M Yoon, IK Curlin, M Fernandez, S AF Rutvisuttinunt, Wiriya Leelawiwat, Wanna Chinnawirotpisan, Piyawan Mueanpai, Famui Kongpechsatit, Oranuch Klungthong, Chonticha O'Connell, Robert de Souza, Mark Yoon, In-Kyu Curlin, Marcel Fernandez, Stefan TI Metagenomics Analysis of Plasma in HIV-infected Men Who Have Sex with Men in Bangkok, Thailand SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Rutvisuttinunt, Wiriya; Chinnawirotpisan, Piyawan; Klungthong, Chonticha; Yoon, In-Kyu; Fernandez, Stefan] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Leelawiwat, Wanna; Mueanpai, Famui; Kongpechsatit, Oranuch; Curlin, Marcel] Thai Minist Publ Hlth US Ctr Dis Prevent Collabor, Nonthaburi, Thailand. [O'Connell, Robert] Armed Forces Res Inst Med Sci, Dept Retrovirol, Bangkok 10400, Thailand. [de Souza, Mark] Thai Red Cross AIDS Res Ctr, South East Asian Res Collaborat Hawaii, Bangkok, Thailand. [Curlin, Marcel] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA P25.08 BP A184 EP A184 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774402104 ER PT J AU Sachdev, DD Ahmed, H Huang, YD Gilbert, P Rerks-Ngarm, S Kaewkungwal, J Nitayaphan, S Michael, N Pitisuttithum, P Robb, M Kim, JH O'Connell, R Frahm, N Morgan, C Buchbinder, SP AF Sachdev, Darpun D. Ahmed, Hasan Huang, Yunda Gilbert, Peter Rerks-Ngarm, Supachai Kaewkungwal, Jaranit Nitayaphan, Sorachai Michael, Nelson Pitisuttithum, Punnee Robb, Merlin Kim, Jerome H. O'Connell, Robert Frahm, Nicole Morgan, Cecilia Buchbinder, Susan P. TI Sex Differences in Immune Variables in the RV144 Trial SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Sachdev, Darpun D.] Univ Calif San Francisco, Ctr AIDS Prevent Studies, San Francisco, CA 94143 USA. [Sachdev, Darpun D.; Buchbinder, Susan P.] San Francisco Dept Publ Hlth, Bridge HIV, San Francisco, CA USA. [Ahmed, Hasan; Huang, Yunda; Gilbert, Peter] SCHARP FHCRC, Seattle, WA USA. [Rerks-Ngarm, Supachai] Thailand MoPH US CDC Collaborat, Dept Dis Control, Nonthaburi, Thailand. [Kaewkungwal, Jaranit] Mahidol Univ, Bangkok 10700, Thailand. [Nitayaphan, Sorachai] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Michael, Nelson] Walter Reed Army Inst Res, US Army Mil HIV Res Program, Silver Spring, MD USA. [Pitisuttithum, Punnee] Mahidol Univ, Vaccine Trials Ctr, Bangkok 10700, Thailand. [Robb, Merlin] Walter Reed Army Inst Res, US Army Mil HIV Res Program, Bethesda, MD USA. [Kim, Jerome H.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [O'Connell, Robert] Armed Forces Res Inst Med Sci, U S Army Med Component, Bangkok 10400, Thailand. [Frahm, Nicole] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Morgan, Cecilia] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USA. [Buchbinder, Susan P.] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA P26.14 BP A191 EP A192 PG 4 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774402121 ER PT J AU Schuetz, A Phuang-Ngern, Y Trichavaroj, R Phanuphak, N Rerknimitr, R Sukhumvittaya, S Jongrakthaitae, S Ratto-Kim, S Fletscher, J Kroon, E Chomchey, N O'Connell, RJ Ngauy, V Phanuphak, P Michael, NL Kim, JH De Souza, MS Ananworanich, J AF Schuetz, Alexandra Phuang-Ngern, Yuwadee Trichavaroj, Rapee Phanuphak, Nittaya Rerknimitr, Rungsun Sukhumvittaya, Suchada Jongrakthaitae, Surat Ratto-Kim, Silvia Fletscher, James Kroon, Eugene Chomchey, Nitaya O'Connell, Robert J. Ngauy, Viseth Phanuphak, Praphan Michael, Nelson L. Kim, Jerome H. De Souza, Mark S. Ananworanich, Jintanat CA RV254 SEARCH 010 Study Grp TI Early Initiation of ART in Acute HIV Infection (Fiebig I to III) Does Not Preclude the Development of HIV-specific Cellular Immune Responses SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Schuetz, Alexandra; Phuang-Ngern, Yuwadee; Trichavaroj, Rapee; Sukhumvittaya, Suchada; Jongrakthaitae, Surat; Kroon, Eugene; O'Connell, Robert J.; Ngauy, Viseth; De Souza, Mark S.] Armed Forces Res Inst Med Sci US Component, Bangkok, Thailand. [Schuetz, Alexandra; Ratto-Kim, Silvia; Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Phanuphak, Nittaya; Fletscher, James; Kroon, Eugene; Chomchey, Nitaya; Phanuphak, Praphan; De Souza, Mark S.; Ananworanich, Jintanat] SEARCH, Bangkok, Thailand. [Phanuphak, Nittaya; Chomchey, Nitaya; Phanuphak, Praphan; De Souza, Mark S.] Thai Red Cross AIDS Res Ctr, Bangkok, Thailand. [Rerknimitr, Rungsun; Phanuphak, Praphan] Chulalongkorn Univ, Dept Med, Bangkok, Thailand. [Ratto-Kim, Silvia; Michael, Nelson L.; Kim, Jerome H.; Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program MHRP, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 3 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA OA05.04 BP A18 EP A18 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774400029 ER PT J AU Shmelkov, S Rao, M Wang, SX Seaman, M Kong, XP Lu, S Cardozo, T AF Shmelkov, Sergey Rao, Mangala Wang, Shixia Seaman, Michael Kong, Xiangpeng Lu, Shan Cardozo, Timothy TI Topology Influences V2 Epitope Focusing SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Shmelkov, Sergey; Kong, Xiangpeng; Cardozo, Timothy] NYU, Sch Med, New York, NY USA. [Rao, Mangala] Walter Reed Army Inst Res, Silver Spring, MD USA. [Wang, Shixia; Lu, Shan] Univ Massachusetts, Sch Med, Worcester, MA USA. [Seaman, Michael] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA P26.18 BP A193 EP A193 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774402125 ER PT J AU Trinh, HV Jobe, O Gao, GF Alving, CR Rao, V Rao, M AF Trinh, Hung V. Jobe, Ousman Gao, Guofen Alving, Carl R. Rao, Venigalla Rao, Mangala TI Characterization of the Binding Affinity of Siglec-1 to gp120, gp145, and V2 Loop via Sialic Acid Binding Motif SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Trinh, Hung V.; Jobe, Ousman] US Mil HIV Res Program MHRP HJF, Lab Adjuvant & Antigen Res, Silver Spring, MD USA. [Gao, Guofen; Rao, Venigalla] Catholic Univ Amer, Dept Biol, Washington, DC 20064 USA. [Alving, Carl R.; Rao, Mangala] Walter Reed Army Inst Res, US Mil HIV Res Program MHRP, Lab Adjuvant & Antigen Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA P10.08 BP A119 EP A120 PG 2 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774401106 ER PT J AU Viegas, EO Tembe, N Nilsson, C Meggi, B Mabota, N Sitoe, N Maueia, C Chissumba, R Cumbane, V Macovela, E Goncalves, E Stout, R Scarlatti, G Wahren, B Andersson, S Marovich, M Robb, M Osman, N Biberfeld, GG Jani, I Sandstrom, E AF Viegas, Edna Omar Tembe, Nelson Nilsson, Charlotta Meggi, Bindiya Mabota, Norma Sitoe, Nadia Maueia, Cremildo Chissumba, Raquel Cumbane, Victoria Macovela, Eulalia Goncalves, Emilia Stout, Rick Scarlatti, Gabriella Wahren, Britta Andersson, Soren Marovich, Mary Robb, Merlin Osman, Nafissa Biberfeld, Gunnel G. Jani, Ilesh Sandstrom, Eric TI Phase I HIV Vaccine Trial to Assess Safety and Immunogenicity of DNA Priming and MVA Boosting in Healthy Mozambican Young Adults SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Viegas, Edna Omar; Tembe, Nelson; Meggi, Bindiya; Mabota, Norma; Sitoe, Nadia; Maueia, Cremildo; Chissumba, Raquel; Cumbane, Victoria; Jani, Ilesh] Inst Nacl Saude, Maputo, Mozambique. [Viegas, Edna Omar; Tembe, Nelson; Nilsson, Charlotta; Wahren, Britta; Biberfeld, Gunnel G.; Sandstrom, Eric] Karolinska Inst, Stockholm, Sweden. [Viegas, Edna Omar; Tembe, Nelson; Macovela, Eulalia; Goncalves, Emilia; Osman, Nafissa] Eduardo Mondlane Univ, Maputo, Mozambique. [Nilsson, Charlotta; Biberfeld, Gunnel G.] Publ Hlth Agcy Sweden, Stockholm, Sweden. [Macovela, Eulalia; Goncalves, Emilia; Osman, Nafissa] Hosp Cent Maputo, Maputo, Mozambique. [Stout, Rick] Bioject Inc, Tualatin, OR USA. [Scarlatti, Gabriella] IRCCS San Raffaele Sci Inst, Milan, Italy. [Andersson, Soren] Orebro Univ Hosp, Orebro, Sweden. [Marovich, Mary; Robb, Merlin] Walter Reed Army Inst Res, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA P26.16 BP A192 EP A192 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774402123 ER PT J AU Wieczorek, L Barrows, B Chenine, AL Braibant, M Srithanaviboonchai, K Pathipvanich, P Krebs, S Michael, NL Tovanabutra, S Kim, JH Robb, M Polonis, V AF Wieczorek, Lindsay Barrows, Brittani Chenine, Agnes-Laurence Braibant, Martine Srithanaviboonchai, Kriengkrai Pathipvanich, Panita Krebs, Shelly Michael, Nelson L. Tovanabutra, Sodsai Kim, Jerome H. Robb, Merlin Polonis, Victoria TI Evaluation of HIV-1 Neutralizing Antibodies in Maternal-infant Transmission in Thailand SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT Symposium on HIV Research for Prevention (HIV R4P) CY OCT 28-31, 2014 CL Cape Town, SOUTH AFRICA C1 [Wieczorek, Lindsay; Barrows, Brittani; Chenine, Agnes-Laurence; Krebs, Shelly; Michael, Nelson L.; Tovanabutra, Sodsai; Kim, Jerome H.; Robb, Merlin; Polonis, Victoria] Mil HIV Res Program, Bethesda, MD USA. [Wieczorek, Lindsay; Barrows, Brittani; Chenine, Agnes-Laurence; Krebs, Shelly; Tovanabutra, Sodsai; Robb, Merlin] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Braibant, Martine] Univ Tours, Tours, France. [Srithanaviboonchai, Kriengkrai] Chiang Mai Univ, Chiang Mai 50000, Thailand. [Pathipvanich, Panita] Lampang Reg Hosp, Lampang, Thailand. [Michael, Nelson L.; Kim, Jerome H.; Polonis, Victoria] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT 1 PY 2014 VL 30 SU 1 MA OA23.01 BP A60 EP A61 PG 6 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AT2OO UT WOS:000344774400134 ER PT J AU Fitgerald, GK Fritz, J Childs, J Brennan, GP Landsittel, DP Neilson, B Gil, A Abbott, JH AF Fitgerald, G. Kelley Fritz, Julie Childs, John Brennan, Gerard P. Landsittel, Douglas P. Neilson, Brett Gil, Alexandra Abbott, J. Haxby TI Exercise, Manual Therapy, and Use of Booster Sessions in Physical Therapy for Knee OA: A Multi-Center Randomized Clinical Trial. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Fitgerald, G. Kelley; Gil, Alexandra] Univ Pittsburgh, Pittsburgh, PA USA. [Fritz, Julie] Univ Utah, Salt Lake City, UT USA. [Childs, John] US Army Baylor Univ, Schertz, TX USA. [Brennan, Gerard P.] Intermt Healthcare, Murray, UT USA. [Landsittel, Douglas P.] Univ Pittsburgh, Ctr Hlth Care Res, Ctr Data, Pittsburgh, PA USA. [Neilson, Brett] Henry M Jackson Fdn, Bethesda, MD USA. [Abbott, J. Haxby] Univ Otago, Dunedin, New Zealand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 889 BP S393 EP S393 PG 1 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384901433 ER PT J AU Schmidt, T Lappan, C Battafarano, D AF Schmidt, Thomas Lappan, Charles Battafarano, Daniel TI Rheumatology e-Consult Services: a Rheumatology Workforce Management Model. SO ARTHRITIS & RHEUMATOLOGY LA English DT Meeting Abstract C1 [Schmidt, Thomas] SAUSHEC Brooke Army Med Ctr, San Antonio, TX USA. [Lappan, Charles] US Army, San Antonio, TX USA. [Battafarano, Daniel] San Antonio Mil Med Ctr, Jbsa Ft Sam Houston, TX USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2326-5191 EI 2326-5205 J9 ARTHRITIS RHEUMATOL JI Arthritis Rheumatol. PD OCT PY 2014 VL 66 SU 10 SI SI MA 103 BP S44 EP S44 PG 1 WC Rheumatology SC Rheumatology GA AS6PK UT WOS:000344384900104 ER PT J AU Hammond, RT AF Hammond, Richard T. TI Equation of motion with gravitational radiation SO INTERNATIONAL JOURNAL OF MODERN PHYSICS D LA English DT Article DE Gravitational radiation reaction; Minkowski spacetime electrodynamics AB A new approach to gravitational radiation reaction is developed which is generalized from a successful solution to the electrodynamic problem in Minkowski spacetime. C1 [Hammond, Richard T.] Univ N Carolina, Dept Phys, Chapel Hill, NC 27514 USA. [Hammond, Richard T.] Army Res Off, Res Triangle Pk, NC 27709 USA. RP Hammond, RT (reprint author), Univ N Carolina, Dept Phys, Chapel Hill, NC 27514 USA. EM rhammond@email.unc.edu NR 8 TC 0 Z9 0 U1 0 U2 1 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE SN 0218-2718 EI 1793-6594 J9 INT J MOD PHYS D JI Int. J. Mod. Phys. D PD OCT PY 2014 VL 23 IS 12 SI SI AR 1442010 DI 10.1142/S0218271814420103 PG 4 WC Astronomy & Astrophysics SC Astronomy & Astrophysics GA AX4SD UT WOS:000346920700017 ER PT J AU Gaddy, CE Cuevas, PF Hartman, LJ Howe, GB Worsham, PL Minogue, TD AF Gaddy, Charla E. Cuevas, Pedro F. Hartman, Laurie J. Howe, Gerald B. Worsham, Patricia L. Minogue, Timothy D. TI Development of real-time PCR assays for specific detection of hmsH, hmsF, hmsR, and irp2 located within the 102-kb pgm locus of Yersinia pestis SO MOLECULAR AND CELLULAR PROBES LA English DT Article DE Yersinia pestis; Real-time PCR; CDC select agents; pgm locus; High pathogenicity island (HPI) ID HIGH-PATHOGENICITY ISLAND; HEMIN-STORAGE LOCUS; PNEUMONIC PLAGUE; PIGMENTATION PHENOTYPE; INSERTION-SEQUENCE; TRANSPORT-SYSTEM; IRON TRANSPORT; VIRULENCE; GENE; SIDEROPHORE AB Virulent isolates of three pathogenic Yersinia species (Yersinia pestis, Yersinia pseudotuberculosis, and Yersinia enterocolitica) harbor a 102-kb chromosomal region which encodes elements critical for virulence. A 35-kb high pathogenicity island is contained in this region, is a known virulence determinant, contains irp1 and irp2 iron-regulating genes. An additional segment, the 68-kb high pathogenicity island, contains genetic elements responsible for conferring the Y. pestis pigmentation phenotype on Congo red agar at 28 degrees C. Collectively, these contiguous segments are referred to as the pigmentation (pgm) locus, the absence of which results in strain attenuation and exemption from CDC Select Agent status. In this study, we developed a set of four real-time PCR assays to detect the presence or absence of multiple virulence genes located within this region. Specifically, we designed TaqMan (R) PCR assays to individually detect three hemin storage genes (hmsH, hmsF, and hmsR) which are genetic elements that confer the pigmentation phenotype, as well as the iron-regulating status of 25 Y. pestis isolates (representing 23 different strains), thus establishing a molecular based assay capable of determining the pgm status of candidate Y. pestis isolates. Included in the validation process, was a comparison of these real-time PCR assays and newly developed conventional PCR assays targeting much larger areas of the 102-kb region (including one assay spanning hmsR and hmsF, one spanning hmsH and hsmF, one targeting hmsF, and one targeting irp2). There was high concordance between the conventional and real-time PCR assays for all Y. pestis strains tested. The results from the comparative analysis document the specificity and sensitivity of the real-time PCR assays and further solidify the ostensible benefits of real-time PCR over conventional PCR. Published by Elsevier Ltd. C1 [Gaddy, Charla E.; Cuevas, Pedro F.; Hartman, Laurie J.; Howe, Gerald B.; Minogue, Timothy D.] US Army, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. [Worsham, Patricia L.] US Army, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. [Hartman, Laurie J.] ClinicaIRM Inc, Hinckley, OH USA. RP Minogue, TD (reprint author), USAMRIID, DSD, 1425 Porter St, Ft Detrick, MD 21702 USA. EM timothy.d.minogue.civ@mail.mil FU Defense Threat Reduction Agency [CB3641]; JSTO-CBD project [CBM.DIAG.02.10.RD.004] FX This work was supported with funds from Defense Threat Reduction Agency (#CB3641) JSTO-CBD project CBM.DIAG.02.10.RD.004. The opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. NR 49 TC 0 Z9 0 U1 1 U2 6 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0890-8508 J9 MOL CELL PROBE JI Mol. Cell. Probes PD OCT-DEC PY 2014 VL 28 IS 5-6 BP 288 EP 295 DI 10.1016/j.mcp.2014.08.004 PG 8 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Cell Biology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Cell Biology GA AW7QW UT WOS:000346460600015 PM 25261118 ER PT J AU Wu, F Rao, SS Prater, JT Zhu, YT Narayan, J AF Wu, F. Rao, S. S. Prater, J. T. Zhu, Y. T. Narayan, J. TI Tuning exchange bias in epitaxial Ni/MgO/TiN heterostructures integrated on Si(100) SO CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE LA English DT Review DE Epitaxial Ni thin films; Exchange bias; Pulsed laser deposition; Domain matching epitaxy ID NI FILMS; THIN-FILM; VAPOR-DEPOSITION; GROWTH; MORPHOLOGY; MGO; CU AB Epitaxial Ni thin films are integrated with tunneling barrier MgO on Si(100) substrate. During pulsed laser deposition, early island-like structure transformed into uniform thin film with increasing number of laser pulses. This led to transitions in exchange bias from positive to negative and back to positive, which is ascribed to morphology associated residual strain. The Ni island structure has a coercive field as high as 3 times of that of the continuous film. The current work holds a tremendous promise in the realization of magnetic devices integrated with the Si-platform. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Wu, F.; Rao, S. S.; Prater, J. T.; Zhu, Y. T.; Narayan, J.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Rao, S. S.; Prater, J. T.] Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. RP Wu, F (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. EM fwu7@ncsu.edu RI Zhu, Yuntian/B-3021-2008; OI Zhu, Yuntian/0000-0002-5961-7422; , fan/0000-0001-5000-0592 FU National Science Foundation of the United States [DMR-1104667]; National Academy of Science (NAS), USA; State of North Carolina; National Science Foundation FX We acknowledge the support by the National Science Foundation of the United States (Grant No. DMR-1104667). SSR acknowledges National Academy of Science (NAS), USA for awarding the NRC postdoctoral research associate fellowship. Also, the authors acknowledge the use of the Analytical Instrumentation Facility (AIF) at North Carolina State University, which is supported by the State of North Carolina and the National Science Foundation. NR 38 TC 5 Z9 5 U1 1 U2 16 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-0286 EI 1879-0348 J9 CURR OPIN SOLID ST M JI Curr. Opin. Solid State Mat. Sci. PD OCT PY 2014 VL 18 IS 5 BP 263 EP 268 DI 10.1016/j.cossms.2014.09.002 PG 6 WC Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA AU3XN UT WOS:000345544100001 ER PT J AU Lund, BJ Lund, DJ Edsall, PR Gaines, VD AF Lund, Brian J. Lund, David J. Edsall, Peter R. Gaines, Victor D. TI Laser-induced retinal damage threshold for repetitive-pulse exposure to 100-mu s pulses SO JOURNAL OF BIOMEDICAL OPTICS LA English DT Article DE laser; laser safety; retina; damage threshold; maximum permissible exposure; repetitive pulse; microcavitation; thermal damage ID PIGMENT-EPITHELIUM; TIME REGIMEN; INJURY; CELLS AB The laser-induced retinal injury thresholds for repetitive-pulse exposures to 100-mu s-duration pulses at a wavelength of 532 nm have been determined for exposures of up to 1000 pulses in an in vivo model. The ED50 was measured for pulse repetition frequencies of 50 and 1000 Hz. Exposures to collimated beams producing a minimal retinal beam spot and to divergent beams producing a 100-mu m-diameter retinal beam spot were considered. The ED50 for a 100-mu s exposure was measured to be 12.8 mu J total intraocular energy for a minimal retinal beam spot exposure and 18.1 mu J total intraocular energy for a 100-mu m-diameter retinal beam spot. The threshold for exposures to N > 1 pulse was found to be the same for both pulse repetition frequencies. The variation of the ED50 with the number of pulses is described well by the probability summation model, in which each pulse is considered an independent event. This is consistent with a threshold-level damage mechanism of microcavitation for single-pulse 100-mu s-duration exposures. The data support the maximum permissible exposure levels for repetitive-pulse exposure promulgated in the most recent laser safety guidelines. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. C1 [Lund, Brian J.; Lund, David J.; Edsall, Peter R.; Gaines, Victor D.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA. RP Lund, BJ (reprint author), US Army Inst Surg Res, 3968 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA. EM brian.j.lund.civ@mail.mil NR 29 TC 2 Z9 2 U1 0 U2 2 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 1083-3668 EI 1560-2281 J9 J BIOMED OPT JI J. Biomed. Opt. PD OCT PY 2014 VL 19 IS 10 AR 105006 DI 10.1117/1.JBO.19.10.105006 PG 7 WC Biochemical Research Methods; Optics; Radiology, Nuclear Medicine & Medical Imaging SC Biochemistry & Molecular Biology; Optics; Radiology, Nuclear Medicine & Medical Imaging GA AU8HM UT WOS:000345837200013 PM 25292166 ER PT J AU Fritz, DL England, MJ Miller, L Waag, DM AF Fritz, David L. England, Marilyn J. Miller, Lynda Waag, David M. TI Mouse Models of Aerosol-Acquired Tularemia Caused by Francisella tularensis Types A and B SO COMPARATIVE MEDICINE LA English DT Article ID BURKHOLDERIA-MALLEI GLANDERS; MACAQUES MACACA-MULATTA; LIVE VACCINE STRAIN; BALB/C MICE; IMMUNE-RESPONSE; INFECTION; OUTBREAK; PROTECTION; AGENT; PATHOGENESIS AB After preliminary assessment of virulence in AKR/J, DBA/1, BALB/c, and C57BL/6 mice, we investigated histopathologic changes in BALB/c and C57BL/6 mice infected with type A (strain SCHU S4) or type B (strain 425) Francisella tularensis by aerosol exposure. In mice exposed to type A infection, changes in histologic presentation were not apparent until day 3 after infection, when pyogranulomatous inflammation was detected in spleens and livers of BALB/c mice, and in lungs and spleens of C57BL/6 mice. Histopathologic changes were most severe and widespread in both mouse strains on day 5 after infection and seemed to completely resolve within 22 d of challenge. BALB/c mice were more resistant than C57BL/6 mice in lethal-dose calculations, but C57BL16 mice cleared the infection more rapidly. Mice similarly challenged with type B F. tularensis also developed histopathologic signs of infection beginning on day 3. The most severe changes were noted on day 8 and were characterized by granulomatous or pyogranulomatous infiltrations of the lungs. Unlike type A infection, lesions due to type B did not resolve over time and remained 3 wk after infection. In type B, but not type A, infection we noted extensive inflammation of the heart muscle. Although no microorganisms were found in tissues of type A survivors beyond 9 d after infection, mice surviving strain 425 infection had a low level of residual infection at 3 wk after challenge. The histopathologic presentation of tularemia caused by F. tularensis types A and B in BALB/c and C57BL/6 mice bears distinct similarities to tularemia in humans. C1 [Fritz, David L.; England, Marilyn J.; Miller, Lynda; Waag, David M.] US Army, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. RP Waag, DM (reprint author), US Army, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. EM david.m.waag.ctr@mail.mil FU Defense Threat Reduction Agency under USAMRIID project [05-4-5P-001] FX This research was funded by the Defense Threat Reduction Agency under USAMRIID project number 05-4-5P-001. NR 49 TC 3 Z9 3 U1 0 U2 2 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1532-0820 J9 COMPARATIVE MED JI Comparative Med. PD OCT PY 2014 VL 64 IS 5 BP 341 EP 350 PG 10 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA AT9RN UT WOS:000345264000001 PM 25402174 ER PT J AU Bland, CM Bookstaver, B Lu, K Dunn, BL Rumley, KF AF Bland, Christopher M. Bookstaver, Brandon Lu, Kevin Dunn, Brianne L. Rumley, Kathey Fulton CA Southeastern Res Grp Endeavor SERG TI Musculoskeletal Safety Outcomes of Patients Receiving Daptomycin with HMG-CoA Reductase Inhibitors SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID STATIN-ASSOCIATED RHABDOMYOLYSIS; GRAM-POSITIVE INFECTIONS; STAPHYLOCOCCUS-AUREUS; THERAPY; SIMVASTATIN; PHARMACOKINETICS; MULTICENTER; BACTEREMIA; TRIAL; OBESE AB Daptomycin, a cyclic lipopeptide antibiotic, and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) are commonly administered in the inpatient setting and are associated with creatine phosphokinase (CPK) elevations, myalgias, and muscle weakness. Safety data for coadministration of daptomycin with statins are limited. To determine the safety of coadministration of daptomycin with statin therapy, a multicenter, retrospective, observational study was performed at 13 institutions in the Southeastern United States. Forty-nine adult patients receiving statins concurrently with daptomycin were compared with 171 patients receiving daptomycin without statin therapy. Detailed information, including treatment indication and duration, infecting pathogen, baseline and subsequent CPK levels, and presence of myalgias or muscle complaints, was collected. Myalgias were noted in 3/49 (6.1%) patients receiving combination therapy compared with 5/171 (2.9%) of patients receiving daptomycin alone (P = 0.38). CPK elevations of > 1,000 U/liter occurred in 5/49 (10.2%) patients receiving combination therapy compared to 9/171 (5.3%) patients receiving daptomycin alone (P = 0.32). Two of five patients experiencing CPK elevations of > 1,000 U/liter in the combination group had symptoms of myopathy. Three patients (6.1%) discontinued therapy due to CPK elevations with concurrent myalgias in the combination group versus 6 patients (3.5%) in the daptomycin-alone group (P = 0.42). CPK levels and myalgias reversed upon discontinuation of daptomycin therapy. Overall musculoskeletal toxicity was numerically higher in the combination group but this result was not statistically significant. Further prospective study is warranted in a larger population. C1 [Bland, Christopher M.] Dwight D Eisenhower Army Med Ctr, Dept Clin Pharm, Ft Gordon, GA 30905 USA. [Bland, Christopher M.; Bookstaver, Brandon; Lu, Kevin; Dunn, Brianne L.] Univ S Carolina, South Carolina Coll Pharm, Dept Clin Pharm & Outcomes Sci, Columbia, SC 29208 USA. [Rumley, Kathey Fulton] Vidant Med Ctr, Dept Internal Med, Greenville, NC USA. [Rumley, Kathey Fulton] Campbell Univ, Sch Pharm, Buies Creek, NC 27506 USA. RP Bland, CM (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Clin Pharm, Ft Gordon, GA 30905 USA. EM chris.bland@us.army.mil FU Cubist Pharmaceuticals FX C. M. Bland is a consultant and member of the speaker's bureau of Cubist Pharmaceuticals. P. B. Bookstaver has received grant funding from Cubist Pharmaceuticals. The other authors have no conflicts to declare. NR 21 TC 4 Z9 4 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD OCT PY 2014 VL 58 IS 10 BP 5726 EP 5731 DI 10.1128/AAC.02910-14 PG 6 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA AS3DT UT WOS:000344157500011 PM 25022580 ER PT J AU Lanteri, CA Chaorattanakawee, S Lon, C Saunders, DL Rutvisuttinunt, W Yingyuen, K Bathurst, I Ding, XC Tyner, SD AF Lanteri, Charlotte A. Chaorattanakawee, Suwanna Lon, Chanthap Saunders, David L. Rutvisuttinunt, Wiriya Yingyuen, Kritsanai Bathurst, Ian Ding, Xavier C. Tyner, Stuart D. TI Ex Vivo Activity of Endoperoxide Antimalarials, Including Artemisone and Arterolane, against Multidrug-Resistant Plasmodium falciparum Isolates from Cambodia SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID IN-VITRO SUSCEPTIBILITY; PFMDR1 COPY NUMBER; WESTERN CAMBODIA; CLINICAL-TRIAL; DIHYDROARTEMISININ-PIPERAQUINE; SYNTHETIC TRIOXOLANE; SOUTHEAST-ASIA; MALARIA; MEFLOQUINE; SENSITIVITY AB Novel synthetic endoperoxides are being evaluated as new components of artemisinin combination therapies (ACTs) to treat artemisinin-resistant Plasmodium falciparum malaria. We conducted blinded ex vivo activity testing of fully synthetic (OZ78 and OZ277) and semisynthetic (artemisone, artemiside, artesunate, and dihydroartemisinin) endoperoxides in the histidine-rich protein 2 enzyme-linked immunosorbent assay against 200 P. falciparum isolates from areas of artemisinin-resistant malaria in western and northern Cambodia in 2009 and 2010. The order of potency and geometric mean (GM) 50% inhibitory concentrations (IC(50)s) were as follows: artemisone (2.40 nM) > artesunate (8.49 nM) > dihydroartemisinin (11.26 nM) > artemiside (15.28 nM) > OZ277 (31.25 nM) > OZ78 (755.27 nM). Ex vivo activities of test endoperoxides positively correlated with dihydroartemisinin and artesunate. The isolates were over 2-fold less susceptible to dihydroartemisinin than the artemisinin-sensitive P. falciparum W2 clone and showed sensitivity comparable to those with test endoperoxides and artesunate, with isolate/W2 IC50 susceptibility ratios of < 2.0. All isolates had P. falciparum chloroquine resistance transporter mutations, with negative correlations in sensitivity to endoperoxides and chloroquine. The activities of endoperoxides (artesunate, dihydroartemisinin, OZ277, and artemisone) significantly correlated with that of the ACT partner drug, mefloquine. Isolates had mutations associated with clinical resistance to mefloquine, with 35% prevalence of P. falciparum multidrug resistance gene 1 (pfmdr1) amplification and 84.5% occurrence of the pfmdr1 Y184F mutation. GM IC(50)s for mefloquine, lumefantrine, and endoperoxides (artesunate, dihydroartemisinin, OZ277, OZ78, and artemisone) correlated with pfmdr1 copy number. Given that current ACTs are failing potentially from reduced sensitivity to artemisinins and partner drugs, newly identified mutations associated with artemisinin resistance reported in the literature and pfmdr1 mutations should be examined for their combined contributions to emerging ACT resistance. C1 [Lanteri, Charlotte A.; Chaorattanakawee, Suwanna; Lon, Chanthap; Saunders, David L.; Rutvisuttinunt, Wiriya; Yingyuen, Kritsanai; Tyner, Stuart D.] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. [Bathurst, Ian; Ding, Xavier C.] Med Malaria Venture, Geneva, Switzerland. RP Lanteri, CA (reprint author), Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. EM charlotte.lanteri@afrims.org FU Medicines for Malaria Venture (MMV); Global Emerging Infections Surveillance (GEIS) Program, U.S. Department of Defense FX This study was funded by the Medicines for Malaria Venture (MMV) and the Global Emerging Infections Surveillance (GEIS) Program, U.S. Department of Defense. NR 53 TC 3 Z9 3 U1 0 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD OCT PY 2014 VL 58 IS 10 BP 5831 EP 5840 DI 10.1128/AAC.02462-14 PG 10 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA AS3DT UT WOS:000344157500023 PM 25049252 ER PT J AU Manning, J Vanachayangkul, P Lon, C Spring, M So, M Sea, D Se, Y Somethy, S Phann, ST Chann, S Sriwichai, S Buathong, N Kuntawunginn, W Mitprasat, M Siripokasupkul, R Teja-Isavadharm, P Soh, E Timmermans, A Lanteri, C Kaewkungwal, J Auayporn, M Tang, D Chour, CM Prom, S Haigney, M Cantilena, L Saunders, D AF Manning, Jessica Vanachayangkul, Pattaraporn Lon, Chanthap Spring, Michele So, Mary Sea, Darapiseth Se, Youry Somethy, Sok Phann, Sut-Thang Chann, Soklyda Sriwichai, Sabaithip Buathong, Nillawan Kuntawunginn, Worachet Mitprasat, Mashamon Siripokasupkul, Raveewan Teja-Isavadharm, Paktiya Soh, Eugene Timmermans, Ans Lanteri, Charlotte Kaewkungwal, Jaranit Auayporn, Montida Tang, Douglas Chour, Char Meng Prom, Satharath Haigney, Mark Cantilena, Louis Saunders, David TI Randomized, Double-Blind, Placebo-Controlled Clinical Trial of a Two-Day Regimen of Dihydroartemisinin-Piperaquine for Malaria Prevention Halted for Concern over Prolonged Corrected QT Interval SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID UNCOMPLICATED PLASMODIUM-FALCIPARUM; ARTEMETHER-LUMEFANTRINE; ANTIMALARIAL-DRUGS; SAFETY EVALUATION; EFFICACY; ADULTS; PHARMACOKINETICS; CHILDREN; CHLOROQUINE; VOLUNTEERS AB Dihydroartemisinin-piperaquine, the current first-line drug for uncomplicated malaria caused by Plasmodium falciparum and Plasmodium vivax in Cambodia, was previously shown to be of benefit as malaria chemoprophylaxis when administered as a monthly 3-day regimen. We sought to evaluate the protective efficacy of a compressed monthly 2-day treatment course in the Royal Cambodian Armed Forces. The safety and efficacy of a monthly 2-day dosing regimen of dihydroartemisinin-piperaquine were evaluated in a two-arm, randomized, double-blind, placebo-controlled cohort study with 2:1 treatment allocation. Healthy military volunteers in areas along the Thai-Cambodian border where there is a high risk of malaria were administered two consecutive daily doses of 180 mg dihydroartemisinin and 1,440 mg piperaquine within 30 min to 3 h of a meal once per month for a planned 4-month period with periodic electrocardiographic and pharmacokinetic assessment. The study was halted after only 6 weeks (69 of 231 projected volunteers enrolled) when four volunteers met a prespecified cardiac safety endpoint of QTcF (Fridericia's formula for correct QT interval) prolongation of > 500 ms. The pharmacodynamic effect on the surface electrocardiogram (ECG) peaked approximately 4 h after piperaquine dosing and lasted 4 to 8 h. Unblinded review by the data safety monitoring board revealed mean QTcF prolongation of 46 ms over placebo at the maximum concentration of drug in serum (C-max) on day 2. Given that dihydroartemisinin-piperaquine is one of the few remaining effective antimalarial agents in Cambodia, compressed 2-day treatment courses of dihydroartemisinin-piperaquine are best avoided until the clinical significance of these findings are more thoroughly evaluated. Because ECG monitoring is often unavailable in areas where malaria is endemic, repolarization risk could be mitigated by using conventional 3-day regimens, fasting, and avoidance of repeated dosing or coadministration with other QT-prolonging medications. C1 [Manning, Jessica; Vanachayangkul, Pattaraporn; Lon, Chanthap; Spring, Michele; Se, Youry; Chann, Soklyda; Sriwichai, Sabaithip; Buathong, Nillawan; Kuntawunginn, Worachet; Mitprasat, Mashamon; Siripokasupkul, Raveewan; Teja-Isavadharm, Paktiya; Timmermans, Ans; Lanteri, Charlotte; Saunders, David] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. [Sea, Darapiseth; Phann, Sut-Thang; Chour, Char Meng] Natl Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia. [So, Mary; Somethy, Sok; Prom, Satharath] Royal Cambodian Armed Forces, Phnom Penh, Cambodia. [Soh, Eugene; Haigney, Mark; Cantilena, Louis] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. [Kaewkungwal, Jaranit; Auayporn, Montida] Mahidol Univ, Ctr Excellence Bioinformat BIOPHICS, Bangkok 10700, Thailand. [Tang, Douglas] Fast Track Biol, Bethesda, MD USA. RP Saunders, D (reprint author), Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. EM David.Saunders@afrims.org NR 36 TC 14 Z9 14 U1 0 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD OCT PY 2014 VL 58 IS 10 BP 6056 EP 6067 DI 10.1128/AAC.02667-14 PG 12 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA AS3DT UT WOS:000344157500050 PM 25092702 ER PT J AU Nielsen, LE Snesrud, EC Onmus-Leone, F Kwak, YI Aviles, R Steele, ED Sutter, DE Waterman, PE Lesho, EP AF Nielsen, Lindsey E. Snesrud, Erik C. Onmus-Leone, Fatma Kwak, Yoon I. Aviles, Ricardo Steele, Eric D. Sutter, Deena E. Waterman, Paige E. Lesho, Emil P. TI IS5 Element Integration, a Novel Mechanism for Rapid In Vivo Emergence of Tigecycline Nonsusceptibility in Klebsiella pneumoniae SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID REAL-TIME PCR; ESCHERICHIA-COLI; ACINETOBACTER-BAUMANNII; EFFLUX PUMP; DECREASED SUSCEPTIBILITY; CARBAPENEMASE GENE; MAJOR ROLE; RESISTANCE; EXPRESSION; INSERTION AB Tigecycline nonsusceptibility is concerning because tigecycline is increasingly relied upon to treat carbapenem-or colistin-resistant organisms. In Enterobacteriaceae, tigecycline nonsusceptibility is mediated by the AcrAB-TolC efflux pump, among others, and pump activity is often a downstream effect of mutations in their transcriptional regulators, cognate repressor genes, or non-coding regions, as demonstrated in Enterobacteriaceae and Acinetobacter isolates. Here, we report the emergence of tigecycline nonsusceptibility in a longitudinal series of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Klebsiella pneumoniae isolates collected during tigecycline therapy and the elucidation of its resistance mechanisms. Clinical isolates were recovered prior to and during tigecycline therapy of a 2.5-month-old Honduran neonate. Antimicrobial susceptibility tests to tigecycline determined that the MIC increased from 1 to 4 mu g/ml prior to the completion of tigecycline therapy. Unlike other studies, we did not find increased expression of ramA, ramR, oqxA, acrB, marA, or rarA genes by reverse transcription-quantitative PCR (qRT-PCR). Whole-genome sequencing revealed an IS5 insertion element in nonsusceptible isolates 85 bp upstream of a putative efflux pump operon, here named kpgABC, previously unknown to be involved in resistance. Introduction of the kpgABC genes in a non-kpgABC background increased the MIC of tigecycline 4-fold and is independent of a functional AcrAB-TolC pump. This is the first report to propose a function for kpgABC and identify an insertion element whose presence correlated with the in vivo development of tigecycline nonsusceptibility in K. pneumoniae. C1 [Nielsen, Lindsey E.; Snesrud, Erik C.; Onmus-Leone, Fatma; Kwak, Yoon I.; Waterman, Paige E.; Lesho, Emil P.] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA. [Aviles, Ricardo] Soto Cano Air Base, Comayagua, Honduras. [Steele, Eric D.] San Antonio Mil Med Ctr, MRSN, San Antonio, TX USA. [Sutter, Deena E.] San Antonio Mil Med Ctr, Div Pediat Infect Dis, San Antonio, TX USA. RP Nielsen, LE (reprint author), Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA. EM Lindsey.e.nielsen2.mil@mail.mil FU U.S. Army Medical Command; Armed Forces Health Surveillance Center's Global Emerging Infections and Response System FX Financial support was provided by the U.S. Army Medical Command and the Armed Forces Health Surveillance Center's Global Emerging Infections and Response System. NR 42 TC 12 Z9 12 U1 1 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD OCT PY 2014 VL 58 IS 10 BP 6151 EP 6156 DI 10.1128/AAC.03053-14 PG 6 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA AS3DT UT WOS:000344157500061 PM 25092708 ER PT J AU Pushpakaran, BN Hinojosa, M Bayne, SB Veliadis, V Urciuoli, D El-Hinnawy, N Borodulin, P Gupta, S Scozzie, C AF Pushpakaran, Bejoy N. Hinojosa, Miguel Bayne, Stephen B. Veliadis, Victor Urciuoli, Damian El-Hinnawy, Nabil Borodulin, Pavel Gupta, Shalini Scozzie, Charles TI Evaluation of SiC JFET Performance During Repetitive Pulsed Switching Into an Unclamped Inductive Load SO IEEE TRANSACTIONS ON PLASMA SCIENCE LA English DT Article DE 1200 V; avalanche mode; depletion mode (DM); junction field-effect transistor (JFET); pulsed testing; silicon carbide (SiC); unclamped inductive switching (UIS) ID CAPABILITY AB Silicon carbide (SiC) depletion mode junction field-effect transistors (JFETs) are well suited for pulsed power applications as an opening switch due to their normally ON (N-ON) nature. To assess the robustness and breakdown energy tolerance of JFETs under pulsed conditions, they must be evaluated for breakdown energy capability before failure. This is very important for circuit breaker applications due to the large voltage spikes induced during the opening of the circuit breaker while it still conducts substantial load current. These voltage spikes can drive the JFET into the breakdown voltage regime and may result in device failure if the energy dissipation is above the tolerance limit. To determine the maximum avalanche energy of the device under repetitive pulsed conditions, a N-ON SiC JFET with a nominal rating of 1200 V/13 A was driven into punchthrough breakdown using an unclamped inductive switching (UIS) circuit. The testing comprised of 4000 repetitive pulses at 25 degrees C case temperature at a fixed gate voltage of -20 V. The drain current was increased after every 1000 pulses to increase the energy dissipated. The JFET was able to withstand 1000 pulses at a maximum energy dissipation value of 1160 mJ before failure. The JFET triode breakdown characteristics were analyzed after every 1000 pulses. The peak UIS energy of 1160 mJ corresponded to an energy density of 16.6 J/cm(2) based on their active area. C1 [Pushpakaran, Bejoy N.; Hinojosa, Miguel; Bayne, Stephen B.] Texas Tech Univ, Dept Elect & Comp Engn, Lubbock, TX 79409 USA. [Veliadis, Victor; El-Hinnawy, Nabil; Borodulin, Pavel; Gupta, Shalini] Northrop Grumman Elect Syst, Linthicum, MD 21090 USA. [Urciuoli, Damian; Scozzie, Charles] US Army Res Lab, Adelphi, MD 20783 USA. RP Pushpakaran, BN (reprint author), Texas Tech Univ, Dept Elect & Comp Engn, Lubbock, TX 79409 USA. EM bejoy.pushpakaran@ttu.edu; miguel.hinojosa@ttu.edu; stephen.bayne@ttu.edu; victor.veliadis@ngc.com; damian.urciuoli@us.army.mil; nabil.elhinnawy@ngc.com; pavel.borodulin@ngc.com; shalini.gupta@ngc.com; charles.scozzie@us.army.mil OI Pushpakaran, Bejoy/0000-0002-1342-5951 FU U.S. Army Research Laboratory FX This work was supported by the U.S. Army Research Laboratory. NR 11 TC 0 Z9 0 U1 0 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0093-3813 EI 1939-9375 J9 IEEE T PLASMA SCI JI IEEE Trans. Plasma Sci. PD OCT PY 2014 VL 42 IS 10 SI SI BP 2968 EP 2973 DI 10.1109/TPS.2014.2309273 PN 2 PG 6 WC Physics, Fluids & Plasmas SC Physics GA AS9EP UT WOS:000344546200014 ER PT J AU Hammond, VH Atwater, MA Darling, KA Nguyen, HQ Kecskes, LJ AF Hammond, Vincent H. Atwater, Mark A. Darling, Kristopher A. Nguyen, Hoang Q. Kecskes, Laszlo J. TI Equal-Channel Angular Extrusion of a Low-Density High-Entropy Alloy Produced by High-Energy Cryogenic Mechanical Alloying SO JOM LA English DT Article ID SOLID-SOLUTION PHASE; MULTICOMPONENT ALLOYS; MICROSTRUCTURE; ELEMENTS; DESIGN; POWDER; SYSTEM AB In this study, we demonstrate the feasibility of forming a bulk consolidated, low-density high-entropy alloy, namely AlFeMgTiZn, which shows reasonable mechanical properties and high hardness. The fabrication of the high-entropy alloy from powdered precursors via high-energy mechanical alloying as a function of milling time is presented. In turn, the evolution of the alloy microstructure with postmilling anneal treatment is elucidated. Last, the severe plastic deformation processing methodology, i.e., equal-channel angular extrusion, chosen for consolidation, is described and shown to result in a bulk product with good results. C1 [Hammond, Vincent H.; Atwater, Mark A.; Darling, Kristopher A.; Nguyen, Hoang Q.; Kecskes, Laszlo J.] US Army Res Lab, Aberdeen, MD 21005 USA. RP Hammond, VH (reprint author), US Army Res Lab, Aberdeen, MD 21005 USA. EM vincent.h.hammond.civ@mail.mil NR 26 TC 5 Z9 5 U1 7 U2 29 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1047-4838 EI 1543-1851 J9 JOM-US JI JOM PD OCT PY 2014 VL 66 IS 10 BP 2021 EP 2029 DI 10.1007/s11837-014-1113-x PG 9 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing SC Materials Science; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing GA AT0HG UT WOS:000344617000009 ER PT J AU Ondigo, BN Hodges, JS Ireland, KF Magak, NG Lanar, DE Dutta, S Narum, DL Park, GS Ofulla, AV John, CC AF Ondigo, Bartholomew N. Hodges, James S. Ireland, Kathleen F. Magak, Ng'wena G. Lanar, David E. Dutta, Sheetij Narum, David L. Park, Gregory S. Ofulla, Ayub V. John, Chandy C. TI Estimation of Recent and Long-Term Malaria Transmission in a Population by Antibody Testing to Multiple Plasmodium falciparum Antigens SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE antibody; elimination; half-life; malaria; Plasmodium falciparum ID NATURALLY ACQUIRED ANTIBODIES; LIVED PLASMA-CELLS; CLINICAL MALARIA; MEROZOITE ANTIGENS; HUMORAL IMMUNITY; SURFACE-ANTIGENS; KENYAN CHILDREN; MIDDLE AMERICA; LOW-PREVALENCE; HIGHLAND AREA AB Background. Tools that estimate recent and long-term malaria transmission in a population would be highly useful for malaria elimination programs. Methods. The prevalence of antibodies to 11 Plasmodium falciparum antigens was assessed by cytometric bead assay or enzyme-linked immunosorbent assay in 1000 people in a highland area of Kenya over 14 months, during a period of interrupted malaria transmission. Results. Antibodies differed by antigen in acquisition with age: rapid (>80% antibody positive by age 20 years, 5 antigens), moderate (>40% positive by age 20 years, 3 antigens), or slow (<40% positive by age 20 years, 3 antigens). Antibody seroreversion rates in the 14 months between samples decreased with age rapidly (7 antigens), slowly (3 antigens), or remained high at all ages (schizont extract). Estimated antibody half-lives in individuals >10 years of age were long (40 to >80 years) for 5 antigens, moderate (5-20 years) for 3 antigens, and short (<1 year) for 3 antigens. Conclusions. Antibodies to P. falciparum antigens in malaria-endemic areas vary by age, antigen, and time since last exposure to P. falciparum. Multiplex P. falciparum antibody testing could provide estimates of long-term and recent malaria transmission and potentially of a population's susceptibility to future clinical malaria. C1 [Ondigo, Bartholomew N.] Maseno Univ, Dept Biomed Sci & Technol, Maseno, Kenya. [Ondigo, Bartholomew N.; Lanar, David E.; Dutta, Sheetij; John, Chandy C.] Kenya Govt Med Res Ctr, Ctr Global Hlth Res, Kisumu, Kenya. [Hodges, James S.] Univ Minnesota, Sch Publ Hlth, Div Biostat, Minneapolis, MN 55414 USA. [Ireland, Kathleen F.; John, Chandy C.] Univ Minnesota, Sch Med, Dept Pediat, Minneapolis, MN 55414 USA. [Magak, Ng'wena G.] Maseno Univ, Dept Med Physiol, Maseno, Kenya. [Narum, David L.] Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD USA. [Park, Gregory S.; Ofulla, Ayub V.] NIAID, Lab Malaria Immunol & Vaccinol, NIH, Rockville, MD USA. RP John, CC (reprint author), Univ Minnesota, Sch Med, Div Global Pediat, 717 Delaware St SE,Room 366,MC 1932, Minneapolis, MN 55414 USA. EM ccj@umn.edu FU National Institute of Allergy and Infectious Diseases (NIAID) [U01 AI056270]; Fogarty International Center [D43 TW0080085, R25 TW009345]; NIAID, National Institutes of Health (NIH) FX This work was supported by grants to C. C. J. from the National Institute of Allergy and Infectious Diseases (NIAID, U01 AI056270) and the Fogarty International Center (D43 TW0080085 and R25 TW009345). This research was supported, in part, by the Intramural Research Program of the NIAID, National Institutes of Health (NIH). NR 39 TC 12 Z9 12 U1 0 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD OCT 1 PY 2014 VL 210 IS 7 BP 1123 EP 1132 DI 10.1093/infdis/jiu225 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AT0ED UT WOS:000344609100017 PM 24737801 ER PT J AU Buddhari, D Aldstadt, J Endy, TP Srikiatkhachorn, A Thaisomboonsuk, B Klungthong, C Nisalak, A Khuntirat, B Jarman, RG Fernandez, S Thomas, SJ Scott, TW Rothman, AL Yoon, IK AF Buddhari, Darunee Aldstadt, Jared Endy, Timothy P. Srikiatkhachorn, Anon Thaisomboonsuk, Butsaya Klungthong, Chonticha Nisalak, Ananda Khuntirat, Benjawan Jarman, Richard G. Fernandez, Stefan Thomas, Stephen J. Scott, Thomas W. Rothman, Alan L. Yoon, In-Kyu TI Dengue Virus Neutralizing Antibody Levels Associated with Protection from Infection in Thai Cluster Studies SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID DEPENDENT ENHANCEMENT; HEMORRHAGIC-FEVER; MOLECULAR-BIOLOGY; ENVELOPE PROTEIN; TIME-INTERVAL; T-CELLS; VILLAGES; COHORT; TRANSMISSION; CHILDREN AB Background: Long-term homologous and temporary heterologous protection from dengue virus (DENV) infection may be mediated by neutralizing antibodies. However, neutralizing antibody titers (NTs) have not been clearly associated with protection from infection. Methodology/Principal Findings: Data from two geographic cluster studies conducted in Kamphaeng Phet, Thailand were used for this analysis. In the first study (2004-2007), cluster investigations of 100-meter radius were triggered by DENV-infected index cases from a concurrent prospective cohort. Subjects between 6 months and 15 years old were evaluated for DENV infection at days 0 and 15 by DENV PCR and IgM ELISA. In the second study (2009-2012), clusters of 200-meter radius were triggered by DENV-infected index cases admitted to the provincial hospital. Subjects of any age >= 6 months were evaluated for DENV infection at days 0 and 14. In both studies, subjects who were DENV PCR positive at day 14/15 were considered to have been "susceptible'' on day 0. Comparison subjects from houses in which someone had documented DENV infection, but the subject remained DENV negative at days 0 and 14/15, were considered "non-susceptible.'' Day 0 samples were presumed to be from just before virus exposure, and underwent plaque reduction neutralization testing (PRNT). Seventeen "susceptible'' (six DENV-1, five DENV-2, and six DENV-4), and 32 "non-susceptible'' (13 exposed to DENV-1, 10 DENV-2, and 9 DENV-4) subjects were evaluated. Comparing subjects exposed to the same serotype, receiver operating characteristic (ROC) curves identified homotypic PRNT titers of 11, 323 and 16 for DENV-1, -2 and -4, respectively, to differentiate "susceptible'' from "non-susceptible'' subjects. Conclusions/Significance: PRNT titers were associated with protection from infection by DENV-1, -2 and -4. Protective NTs appeared to be serotype-dependent and may be higher for DENV-2 than other serotypes. These findings are relevant for both dengue epidemiology studies and vaccine development efforts. C1 [Buddhari, Darunee; Thaisomboonsuk, Butsaya; Klungthong, Chonticha; Nisalak, Ananda; Khuntirat, Benjawan; Fernandez, Stefan; Yoon, In-Kyu] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Aldstadt, Jared] SUNY Buffalo, Dept Geog, Buffalo, NY 14260 USA. [Endy, Timothy P.] SUNY Syracuse, Dept Infect Dis, Syracuse, NY USA. [Srikiatkhachorn, Anon] Univ Massachusetts, Sch Med, Dept Med, Div Infect Dis & Immunol, Worcester, MA 01605 USA. [Jarman, Richard G.; Thomas, Stephen J.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA. [Scott, Thomas W.] Univ Calif Davis, Dept Entomol & Nematol, Davis, CA 95616 USA. [Scott, Thomas W.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. [Rothman, Alan L.] Univ Rhode Isl, Inst Immunol & Informat, Providence, RI 02908 USA. RP Buddhari, D (reprint author), Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. EM daruneet@afrims.org RI Aldstadt, Jared/A-8508-2009 OI Aldstadt, Jared/0000-0001-9162-7439 FU National Institutes of Health [P01 AI34533, R01 GM083224]; U.S. Military Infectious Diseases Research Program [S0016-04-AF]; Bill & Melinda Gates Foundation Global Health Program [OPP52250] FX This research was funded, in part, by the National Institutes of Health (grants P01 AI34533 and R01 GM083224); the U.S. Military Infectious Diseases Research Program (grant S0016-04-AF); The Bill & Melinda Gates Foundation Global Health Program (grant OPP52250). The funding source had no role in the study design, data collection, analysis and interpretation, manuscript writing, or manuscript submission for publication. NR 37 TC 19 Z9 19 U1 1 U2 10 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD OCT PY 2014 VL 8 IS 10 AR e3230 DI 10.1371/journal.pntd.0003230 PG 10 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AS9WJ UT WOS:000344589000046 PM 25329173 ER PT J AU Hermann, LL Thaisomboonsuk, B Poolpanichupatam, Y Jarman, RG Kalayanarooj, S Nisalak, A Yoon, IK Fernandez, S AF Hermann, Laura L. Thaisomboonsuk, Butsaya Poolpanichupatam, Yongyuth Jarman, Richard G. Kalayanarooj, Siripen Nisalak, Ananda Yoon, In-Kyu Fernandez, Stefan TI Evaluation of a Dengue NS1 Antigen Detection Assay Sensitivity and Specificity for the Diagnosis of Acute Dengue Virus Infection SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID LINKED-IMMUNOSORBENT-ASSAY; ACUTE FEBRILE ILLNESS; CAPTURE ELISA; NONSTRUCTURAL-1 ANTIGEN; ANTIBODY-RESPONSES; PROTEIN NS1; HUMAN SERUM; TESTS; ACCURACY; IMMUNOASSAY AB Background: Currently, no dengue NS1 detection kit has regulatory approval for the diagnosis of acute dengue fever. Here we report the sensitivity and specificity of the InBios DEN Detect NS1 ELISA using a panel of well characterized human acute fever serum specimens. Methodology/Principal Findings: The InBios DENV Detect NS1 ELISA was tested using a panel composed of 334 serum specimens collected from acute febrile patients seeking care in a Bangkok hospital in 2010 and 2011. Of these patients, 314 were found to have acute dengue by either RT-PCR and/or anti-dengue IgM/IgG ELISA. Alongside the InBios NS1 ELISA kit, we compared the performance characteristics of the BioRad Platelia NS1 antigen kit. The InBios NS1 ELISA Ag kit had a higher overall sensitivity (86% vs 72.8%) but equal specificity (100%) compared to the BioRad Platelia kit. The serological status of the patient significantly influenced the outcome. In primary infections, the InBios NS1 kit demonstrated a higher sensitivity (98.8%) than in secondary infections (83.5%). We found significant variation in the sensitivity of the InBios NS1 ELISA kit depending on the serotype of the dengue virus and also found decreasing sensitivity the longer after the onset of illness, showing 100% sensitivity early during illness, but dropping below 50% by Day 7. Conclusion/Significance: The InBios NS1 ELISA kit demonstrated high accuracy when compared to the initial clinical diagnosis with greater than 85% agreement when patients were clinically diagnosed with dengue illness. Results presented here suggest the accurate detection of circulating dengue NS1 by the InBios DENV Detect NS1 ELISA can provide clinicians with a useful tool for diagnosis of early dengue infections. C1 [Hermann, Laura L.] Univ Toronto, Dept Med, Toronto, ON, Canada. [Hermann, Laura L.; Thaisomboonsuk, Butsaya; Poolpanichupatam, Yongyuth; Nisalak, Ananda; Yoon, In-Kyu; Fernandez, Stefan] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Jarman, Richard G.] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Viral Dis Branch, Washington, DC 20307 USA. [Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. RP Hermann, LL (reprint author), Univ Toronto, Dept Med, Toronto, ON, Canada. EM stefan.fernandez@afrims.org FU InBios; Canadian Institutes of Health Research Fellowship FX This work was funded by InBios. LLH was funded by the Canadian Institutes of Health Research Fellowship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 41 TC 12 Z9 14 U1 0 U2 13 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD OCT PY 2014 VL 8 IS 10 AR e3193 DI 10.1371/journal.pntd.0003193 PG 8 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AS9WJ UT WOS:000344589000017 PM 25275493 ER PT J AU Yadava, A Hall, CE Sullivan, JS Nace, D Williams, T Collins, WE Ockenhouse, CF Barnwell, JW AF Yadava, Anjali Hall, Cysha E. Sullivan, Joann S. Nace, Douglas Williams, Tyrone Collins, William E. Ockenhouse, Christian F. Barnwell, John W. TI Protective Efficacy of a Plasmodium vivax Circumsporozoite Protein-Based Vaccine in Aotus nancymaae Is Associated with Antibodies to the Repeat Region SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID RECOMBINANT MALARIA VACCINE; MULTIPLE ANTIGEN CONSTRUCT; MONKEYS; IMMUNOGENICITY; IMMUNIZATION; PEPTIDES; EPITOPE; MAP AB We have previously reported that Vivax Malaria Protein 001 (VMP001), a vaccine candidate based on the circumsporozoite protein of Plasmodium vivax, is immunogenic in mice and rhesus monkeys in the presence of various adjuvants. In the present study, we evaluated the immunogenicity and efficacy of VMP001 formulated with a TLR9 agonist in a water-in-oil emulsion. Following immunization, the vaccine efficacy was assessed by challenging Aotus nancymaae monkeys with P. vivax sporozoites. Monkeys from both the low-and high-dose vaccine groups generated strong humoral immune responses to the vaccine (peak median titers of 291,622), and its subunits (peak median titers to the N-term, central repeat and C-term regions of 22,188; 66,120 and 179,947, respectively). 66.7% of vaccinated monkeys demonstrated sterile protection following challenge. Protection was associated with antibodies directed against the central repeat region. The protected monkeys had a median anti-repeat titer of 97,841 compared to 14,822 in the non-protected monkeys. This is the first report demonstrating P. vivax CSP vaccine-induced protection of Aotus monkeys challenged with P. vivax sporozoites. C1 [Yadava, Anjali; Hall, Cysha E.; Ockenhouse, Christian F.] Walter Reed Army Inst Res, Malaria Vaccine Branch, Mil Malaria Res Program, Silver Spring, MD 20910 USA. [Sullivan, Joann S.; Nace, Douglas; Williams, Tyrone; Collins, William E.; Barnwell, John W.] Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis & Malaria, Atlanta, GA USA. RP Yadava, A (reprint author), Walter Reed Army Inst Res, Malaria Vaccine Branch, Mil Malaria Res Program, Silver Spring, MD 20910 USA. EM Anjali.Yadava.Civ@mail.mil FU Military Infectious Diseases Research Program, Maryland; Centers for Disease Control, Atlanta FX This work was supported by intramural funding from the Military Infectious Diseases Research Program, Maryland and the Centers for Disease Control, Atlanta. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 22 TC 7 Z9 7 U1 1 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD OCT PY 2014 VL 8 IS 10 AR e3268 DI 10.1371/journal.pntd.0003268 PG 11 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AS9WJ UT WOS:000344589000072 PM 25329054 ER PT J AU Knoblauch, C Griep, M Friedrich, C AF Knoblauch, Christopher Griep, Mark Friedrich, Craig TI Recent Advances in the Field of Bionanotechnology: An Insight into Optoelectric Bacteriorhodopsin, Quantum Dots, and Noble Metal Nanoclusters SO SENSORS LA English DT Review DE bacteriorhodopsin; quantum dots; noble metal nanoclusters; biosensor; molecular sensor; molecular electronics; bioelectronics; bionanotechnology; solar cell; fluorescent sensor ID RESONANCE ENERGY-TRANSFER; LANGMUIR-BLODGETT-FILMS; FLUORESCENT GOLD NANOCLUSTERS; TEMPLATED GOLD/SILVER NANOCLUSTERS; ELECTRODE-ELECTROLYTE INTERFACE; EFFECT TRANSISTOR PHOTORECEIVER; PURPLE MEMBRANE; SILVER NANOCLUSTERS; SELECTIVE DETECTION; AG NANOCLUSTERS AB Molecular sensors and molecular electronics are a major component of a recent research area known as bionanotechnology, which merges biology with nanotechnology. This new class of biosensors and bioelectronics has been a subject of intense research over the past decade and has found application in a wide variety of fields. The unique characteristics of these biomolecular transduction systems has been utilized in applications ranging from solar cells and single-electron transistors (SETs) to fluorescent sensors capable of sensitive and selective detection of a wide variety of targets, both organic and inorganic. This review will discuss three major systems in the area of molecular sensors and electronics and their application in unique technological innovations. Firstly, the synthesis of optoelectric bacteriorhodopsin (bR) and its application in the field of molecular sensors and electronics will be discussed. Next, this article will discuss recent advances in the synthesis and application of semiconductor quantum dots (QDs). Finally, this article will conclude with a review of the new and exciting field of noble metal nanoclusters and their application in the creation of a new class of fluorescent sensors. C1 [Knoblauch, Christopher; Friedrich, Craig] Michigan Technol Univ, Dept Mech Engn Engn Mech, Multiscale Technol Inst, Houghton, MI 49931 USA. [Griep, Mark] Weap & Mat Res Directorate, US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Friedrich, C (reprint author), Michigan Technol Univ, Dept Mech Engn Engn Mech, Multiscale Technol Inst, 1400 Townsend Dr, Houghton, MI 49931 USA. EM cjknobla@mtu.edu; mark.h.griep.civ@mail.mil; craig@mtu.edu NR 176 TC 4 Z9 5 U1 10 U2 101 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1424-8220 J9 SENSORS-BASEL JI Sensors PD OCT PY 2014 VL 14 IS 10 BP 19731 EP 19766 DI 10.3390/s141019731 PG 36 WC Chemistry, Analytical; Electrochemistry; Instruments & Instrumentation SC Chemistry; Electrochemistry; Instruments & Instrumentation GA AS7SS UT WOS:000344455700098 PM 25340449 ER PT J AU Boedihardjo, AP Lu, CT Wang, BS AF Boedihardjo, Arnold P. Lu, Chang-Tien Wang, Bingsheng TI A Framework for Exploiting Local Information to Enhance Density Estimation of Data Streams SO ACM TRANSACTIONS ON KNOWLEDGE DISCOVERY FROM DATA LA English DT Article DE Local region information; General Local rEgion AlgorithM (GLEAM) ID BANDWIDTH SELECTION; HISTOGRAMS; ALGORITHMS; CHOICE AB The Probability Density Function (PDF) is the fundamental data model for a variety of stream mining algorithms. Existing works apply the standard nonparametric Kernel Density Estimator (KDE) to approximate the PDF of data streams. As a result, the stream-based KDEs cannot accurately capture complex local density features. In this article, we propose the use of Local Region (LRs) to model local density information in univariate data streams. In-depth theoretical analyses are presented to justify the effectiveness of the LR-based KDE. Based on the analyses, we develop the General Local rEgion AlgorithM (GLEAM) to enhance the estimation quality of structurally complex univariate distributions for existing stream-based KDEs. A set of algorithmic optimizations is designed to improve the query throughput of GLEAM and to achieve its linear order computation. Additionally, a comprehensive suite of experiments was conducted to test the effectiveness and efficiency of GLEAM. C1 [Boedihardjo, Arnold P.] US Army Corps Engineers, Geospatial Res Lab, Engineer Res & Dev Ctr, Alexandria, VA 22315 USA. [Lu, Chang-Tien; Wang, Bingsheng] Virginia Tech, Dept Comp Sci, Falls Church, VA 22043 USA. RP Boedihardjo, AP (reprint author), US Army Corps Engineers, Geospatial Res Lab, Engineer Res & Dev Ctr, 7701 Telegraph Rd, Alexandria, VA 22315 USA. NR 48 TC 0 Z9 0 U1 1 U2 3 PU ASSOC COMPUTING MACHINERY PI NEW YORK PA 2 PENN PLAZA, STE 701, NEW YORK, NY 10121-0701 USA SN 1556-4681 EI 1556-472X J9 ACM T KNOWL DISCOV D JI ACM Trans. Knowl. Discov. Data PD OCT PY 2014 VL 9 IS 1 AR 2 DI 10.1145/2629618 PG 38 WC Computer Science, Information Systems; Computer Science, Software Engineering SC Computer Science GA AS6CW UT WOS:000344353300002 ER PT J AU Owens, BD AF Owens, Brett D. TI Athletic Injuries in the Military Preface SO CLINICS IN SPORTS MEDICINE LA English DT Editorial Material C1 US Mil Acad, Uniformed Serv Univ, Keller Army Hosp, West Point, NY 10996 USA. RP Owens, BD (reprint author), US Mil Acad, Uniformed Serv Univ, Keller Army Hosp, West Point, NY 10996 USA. EM owensbrett@gmail.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0278-5919 EI 1556-228X J9 CLIN SPORT MED JI Clin. Sports Med. PD OCT PY 2014 VL 33 IS 4 BP XV EP XVI DI 10.1016/j.csm.2014.07.001 PG 2 WC Sport Sciences SC Sport Sciences GA AS7KJ UT WOS:000344434800002 PM 25280623 ER PT J AU Owens, BD Tokish, JM Provencher, MT AF Owens, Brett D. Tokish, John M. Provencher, Matthew T. TI Dedication SO CLINICS IN SPORTS MEDICINE LA English DT Editorial Material C1 [Owens, Brett D.] Uniformed Serv Univ Hlth Sci, US Mil Acad, Keller Army Hosp, West Point, NY 10996 USA. [Tokish, John M.] Steadman Hawkins Clin Carolinas, Greenville, SC 29615 USA. [Provencher, Matthew T.] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Sports Med Serv, Boston, MA 02114 USA. RP Owens, BD (reprint author), Uniformed Serv Univ Hlth Sci, US Mil Acad, Keller Army Hosp, West Point, NY 10996 USA. EM owensbrett@gmail.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0278-5919 EI 1556-228X J9 CLIN SPORT MED JI Clin. Sports Med. PD OCT PY 2014 VL 33 IS 4 BP XVII EP XVIII DI 10.1016/j.csm.2014.07.002 PG 2 WC Sport Sciences SC Sport Sciences GA AS7KJ UT WOS:000344434800003 PM 25280624 ER PT J AU Cameron, KL Owens, BD AF Cameron, Kenneth L. Owens, Brett D. TI The Burden and Management of Sports-Related Musculoskeletal Injuries and Conditions Within the US Military SO CLINICS IN SPORTS MEDICINE LA English DT Article DE Sports medicine; Physical training; Musculoskeletal conditions; Injuries; Military ID UNITED-STATES MILITARY; ANTERIOR CRUCIATE LIGAMENT; FORCE SAFETY CENTER; TRAUMATIC PATELLAR DISLOCATION; TRAINING-RELATED INJURIES; OPERATION IRAQI FREEDOM; LOW-BACK-PAIN; RISK-FACTORS; SERVICE MEMBERS; AIR-FORCE AB Because of the volume of sports-related musculoskeletal injuries experienced by military service members, the US Department of Defense has begun to implement the sports medicine model of care to improve the access, efficiency, and effectiveness of care for soldiers who experience musculoskeletal injuries related to sports and training. In this article, the burden of musculoskeletal injuries and conditions related to sports and physical fitness training within the military is reviewed, and the application of the sports medicine model to care for these injuries in military service members is described. C1 [Cameron, Kenneth L.; Owens, Brett D.] US Mil Acad, Keller Army Hosp, Dept Orthopaed Surg, West Point, NY 10996 USA. RP Cameron, KL (reprint author), US Mil Acad, Keller Army Hosp, Dept Orthopaed Surg, 900 Washington Rd, West Point, NY 10996 USA. EM kenneth.l.cameron.civ@mail.mil OI Cameron, Kenneth/0000-0002-6276-4482 NR 64 TC 6 Z9 6 U1 1 U2 6 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0278-5919 EI 1556-228X J9 CLIN SPORT MED JI Clin. Sports Med. PD OCT PY 2014 VL 33 IS 4 BP 573 EP + DI 10.1016/j.csm.2014.06.004 PG 18 WC Sport Sciences SC Sport Sciences GA AS7KJ UT WOS:000344434800004 PM 25280610 ER PT J AU Jacobs, JM Cameron, KL Bojescul, JA AF Jacobs, Jeremy M. Cameron, Kenneth L. Bojescul, John A. TI Lower Extremity Stress Fractures in the Military SO CLINICS IN SPORTS MEDICINE LA English DT Article DE Stress fracture; Military; Recruit; Femoral neck ID FEMALE NAVY RECRUITS; FEMORAL-SHAFT; FATIGUE FRACTURES; RISK-FACTORS; VITAMIN-D; SURGICAL-MANAGEMENT; MEDIAL MALLEOLUS; NATURAL-HISTORY; MARINE RECRUITS; 5TH METATARSAL AB Stress fractures of the lower extremities are common among the military population and athletes. Service members are typically at the greatest risk for stress fracture during basic combat training and initial entry-level training, and it may be related to poor indices of entry-level physical fitness. The purpose of this study is to review the epidemiology and incidence of stress fractures and common stress fractures' diagnosis and treatment and to investigate modifiable and nonmodifiable risk factors and injury prevention. In the soldier or athlete who presents with activity-related pain, stress fractures should be given significant consideration during the clinical evaluation. C1 [Jacobs, Jeremy M.; Bojescul, John A.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA. [Cameron, Kenneth L.] Keller Army Community Hosp, West Point, NY 10996 USA. RP Bojescul, JA (reprint author), Dwight D Eisenhower Army Med Ctr, 300 E Hosp Rd, Ft Gordon, GA 30905 USA. EM John.a.bojescul2.mil@mail.mil OI Cameron, Kenneth/0000-0002-6276-4482 NR 98 TC 6 Z9 6 U1 3 U2 17 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0278-5919 EI 1556-228X J9 CLIN SPORT MED JI Clin. Sports Med. PD OCT PY 2014 VL 33 IS 4 BP 591 EP + DI 10.1016/j.csm.2014.06.002 PG 24 WC Sport Sciences SC Sport Sciences GA AS7KJ UT WOS:000344434800005 PM 25280611 ER PT J AU Padua, DA Frank, B Donaldson, A de la Motte, S Cameron, KL Beutler, AI DiStefano, LJ Marshall, SW AF Padua, Darin A. Frank, Barnett Donaldson, Alex de la Motte, Sarah Cameron, Kenneth L. Beutler, Anthony I. DiStefano, Lindsay J. Marshall, Stephen W. TI Seven Steps for Developing and Implementing a Preventive Training Program Lessons Learned from JUMP-ACL and Beyond SO CLINICS IN SPORTS MEDICINE LA English DT Article DE Implementation; Injury prevention; Research framework; Program design; Sports; Military ID CRUCIATE LIGAMENT INJURY; SPORTS INJURY; SOCCER PLAYERS; WARM-UP; FRAMEWORK; RECOMMENDATIONS; POPULATIONS; MILITARY; FOOTBALL; SCIENCE AB Musculoskeletal injuries during military and sport-related training are common, costly, and potentially debilitating. There is a need to develop and implement evidence-based injury prevention strategies to reduce the burden of musculoskeletal injury. The lack of attention to implementation issues is a major factor limiting the ability to successfully reduce musculoskeletal injury rates using evidence-based injury prevention programs. This article proposes 7 steps that can be used to facilitate successful design and implementation of evidence-based injury prevention programs within the logical constraints of a real-world setting by identifying implementation barriers and associated solutions. C1 [Padua, Darin A.] Univ N Carolina, Dept Exercise & Sport Sci, Chapel Hill, NC 27599 USA. [Frank, Barnett] Univ N Carolina, Dept Exercise & Sport Sci, Human Movement Sci Curriculum, Chapel Hill, NC 27599 USA. [Donaldson, Alex] Federat Univ Australia, Australian Ctr Res Injury Sport & Its Prevent, Ballarat, Vic, Australia. [de la Motte, Sarah; Beutler, Anthony I.] Uniformed Serv Univ Hlth Sci, Consortium Hlth & Mil Performance, Bethesda, MD 20814 USA. [Cameron, Kenneth L.] Keller Army Hosp, West Point, NY USA. [DiStefano, Lindsay J.] Univ Connecticut, Dept Kinesiol, Storrs, CT USA. [Marshall, Stephen W.] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27599 USA. RP Padua, DA (reprint author), Univ N Carolina, Dept Exercise & Sport Sci, 204 Fetzer Hall,CB 8700, Chapel Hill, NC 27599 USA. EM dpadua@email.unc.edu OI Marshall, Stephen/0000-0002-2664-9233; Cameron, Kenneth/0000-0002-6276-4482 FU NIAMS NIH HHS [R01 AR050461] NR 29 TC 6 Z9 6 U1 2 U2 7 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0278-5919 EI 1556-228X J9 CLIN SPORT MED JI Clin. Sports Med. PD OCT PY 2014 VL 33 IS 4 BP 615 EP + DI 10.1016/j.csm.2014.06.012 PG 20 WC Sport Sciences SC Sport Sciences GA AS7KJ UT WOS:000344434800006 PM 25280612 ER PT J AU Svoboda, SJ AF Svoboda, Steven J. TI ACL Injury and Posttraumatic Osteoarthritis SO CLINICS IN SPORTS MEDICINE LA English DT Article DE ACL injury; Posttraumatic osteoarthritis; Biomarkers; Biomechanics ID CRUCIATE LIGAMENT INJURY; PHYSICIAN-DIAGNOSED OSTEOARTHRITIS; KNEE OSTEOARTHRITIS; FOLLOW-UP; UNITED-STATES; PREVALENCE; RECONSTRUCTION; BIOMARKERS; ARTHRITIS AB Osteoarthritis is observed with a much higher incidence in the military than comparable civilian populations. The diagnosis is often made at a younger age in military members. Anterior cruciate ligament (ACL) ruptures are endemic injuries to the young, active military athlete population. Posttraumatic osteoarthritis (PTOA) occurs commonly in the post-ACL-injured knee. Recent efforts by national organizations have brought attention to the unique opportunity to study PTOA in its earliest, molecular stages in knees sustaining traumatic injuries to the ACL. The search for surrogate biomarkers of PTOA in the military population offers opportunity to advance understanding of this significant disease. C1 Keller Army Community Hosp, West Point, NY 10996 USA. RP Svoboda, SJ (reprint author), Keller Army Community Hosp, 900 Washington Rd, West Point, NY 10996 USA. EM steven.j.svoboda.mil@mail.mil NR 22 TC 3 Z9 5 U1 4 U2 19 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0278-5919 EI 1556-228X J9 CLIN SPORT MED JI Clin. Sports Med. PD OCT PY 2014 VL 33 IS 4 BP 633 EP + DI 10.1016/j.csm.2014.06.008 PG 9 WC Sport Sciences SC Sport Sciences GA AS7KJ UT WOS:000344434800007 PM 25280613 ER PT J AU Haley, CA Zacchilli, MA AF Haley, Chad A. Zacchilli, Michael A. TI Pectoralis Major Injuries Evaluation and Treatment SO CLINICS IN SPORTS MEDICINE LA English DT Article DE Pectoralis major muscle; Tendon rupture; Tendon tear; Tendon repair; Cortical button ID DELAYED REPAIR; TENDON-RUPTURE; BIOMECHANICAL ANALYSIS; MUSCLE; TEARS; DIAGNOSIS; RECONSTRUCTION; COMPLICATION; MANAGEMENT; ALLOGRAFT AB Pectoralis major (PM) tendon tears are relatively rare injuries that most commonly occur in the 20- to 40 year-old male athlete engaged in weight-lifting exercises, such as when performing a bench press. An accurate and timely diagnosis of a PM tear is important because most studies report better outcomes with acute surgical repair. This article describes the anatomy of the PM muscle, injury epidemiology, tear classification, diagnosis including physical examination and imaging, treatment options for both nonoperative and operative management, complications, a review of the literature including military-related studies, and the authors' preferred technique. C1 [Haley, Chad A.] Keller Army Community Hosp, Dept Surg, West Point, NY 10996 USA. [Zacchilli, Michael A.] Womack Army Med Ctr, Dept Orthopaed & Rehabil, Ft Bragg, NC 28310 USA. RP Haley, CA (reprint author), Keller Army Community Hosp, Dept Surg, Bldg 900, West Point, NY 10996 USA. EM chad.a.haley.mil@mail.mil NR 58 TC 5 Z9 5 U1 0 U2 2 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0278-5919 EI 1556-228X J9 CLIN SPORT MED JI Clin. Sports Med. PD OCT PY 2014 VL 33 IS 4 BP 739 EP + DI 10.1016/j.csm.2014.06.005 PG 19 WC Sport Sciences SC Sport Sciences GA AS7KJ UT WOS:000344434800014 PM 25280620 ER PT J AU Patzkowski, JC Owens, BD Burns, TC AF Patzkowski, Jeanne C. Owens, Brett D. Burns, Travis C. TI Snapping Scapula Syndrome in the Military SO CLINICS IN SPORTS MEDICINE LA English DT Article DE Snapping scapula syndrome; Chest wall; Military; Bursa ID MANAGEMENT; ANATOMY AB Snapping scapula syndrome is a rare condition that presents with symptoms ranging from crepitus to disabling pain in the scapulothoracic articulation. This condition may be more frequent in a military population because of physical fitness standards that require nonphysiologic forces to be applied to the scapulothoracic articulation. Nonoperative therapy is the first-line management. Surgical options include arthroscopic or open scapulothoracic bursectomy with or without partial scapulectomy. After scapulothoracic arthroscopy up to 90% of patients report good/excellent results, up to 90% are able to return to work, and more than 60% return to sports. C1 [Patzkowski, Jeanne C.; Burns, Travis C.] San Antonio Mil Med Ctr, Orthopaed Surg Serv, Ft Sam Houston, TX 78234 USA. [Owens, Brett D.] Keller Army Community Hosp, Orthopaed Surg Serv, West Point, NY 10996 USA. RP Patzkowski, JC (reprint author), San Antonio Mil Med Ctr, Orthopaed Surg Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM jeanne.patzkowski@gmail.com NR 22 TC 0 Z9 1 U1 0 U2 4 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0278-5919 EI 1556-228X J9 CLIN SPORT MED JI Clin. Sports Med. PD OCT PY 2014 VL 33 IS 4 BP 757 EP + DI 10.1016/j.csm.2014.06.003 PG 11 WC Sport Sciences SC Sport Sciences GA AS7KJ UT WOS:000344434800015 PM 25280621 ER PT J AU Anand, S Sengupta, S Hong, K Subbalakshmi, KP Chandramouli, R Cam, H AF Anand, Santhanakrishnan Sengupta, Shamik Hong, Kai Subbalakshmi, K. P. (Suba) Chandramouli, R. (Mouli) Cam, Hasan TI Exploiting Channel Fragmentation and Aggregation/Bonding to Create Security Vulnerabilities SO IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY LA English DT Article DE Aggregation/bonding; channel fragmentation; service disruption; vulnerability AB We address a unique security vulnerability due to spectrum fragmentation, aggregation, and bonding in IEEE 802.22-based dynamic spectrum access (DSA) networks and in Long-Term Evolution (LTE) and Evolved High-Speed Packet Access (HSPA+) networks. Typically, channel fragmentation, aggregation, and bonding have been perceived as a means of enhancing the bandwidth and throughput for the users. However, this could also result in losing orthogonality between the bonded or fragmented spectrum bands. We show this leads to a security vulnerability that can be exploited by an attacker to cause service disruptions. We present an analysis of two types of attacks, i.e., the MAXimum IMPact (MAXIMP) attack, wherein the attackers try to cause maximum service disruptions by transmitting at maximum power, and the MINPOWattack, wherein the attackers transmit at minimum power just to create a targeted level of service disruption. Results indicate that, although the MAXIMP attack can cause up to about 16% loss in the capacity of the system, the MINimum POWer (MINPOW) attack, which is more difficult to detect than the MAXIMP attack, can cause 11%-15% loss in throughput. C1 [Anand, Santhanakrishnan] Polytech Inst New York, Dept Technol Management & Innovat, Brooklyn, NY 11201 USA. [Sengupta, Shamik] Univ Nevada, Dept Comp Sci & Engn, Reno, NV 89503 USA. [Hong, Kai; Subbalakshmi, K. P. (Suba); Chandramouli, R. (Mouli)] Stevens Inst Technol, Dept Elect & Comp Engn, Hoboken, NJ 07030 USA. [Cam, Hasan] US Army Res Lab, Adelphi, MD 20783 USA. [Subbalakshmi, K. P. (Suba)] Stevens Inst Technol, Hoboken, NJ 07030 USA. [Subbalakshmi, K. P. (Suba)] IEEE TCCN, Cognit Network Secur Special Interest Grp, Sydney, NSW, Australia. [Subbalakshmi, K. P. (Suba); Chandramouli, R. (Mouli)] Dynam Spectrum LLC, Hoboken, NJ USA. [Subbalakshmi, K. P. (Suba); Chandramouli, R. (Mouli)] Jaasuz Com, New York, NY USA. [Chandramouli, R. (Mouli)] IEEE Commun Soc IEEE ComSoc, Kansas City, KS USA. [Chandramouli, R. (Mouli)] IEEE ComSoc Tech Comm Cognit Networks TCCN, Sydney, NSW, Australia. [Cam, Hasan] Altusys, Princeton, NJ USA. RP Anand, S (reprint author), Polytech Inst New York, Dept Technol Management & Innovat, 333 Jay St, Brooklyn, NY 11201 USA. EM as8547@nyu.edu; ssengupta@unr.edu; khong@stevens.edu; ksubbala@stevens.edu; mouli@stevens.edu; hasan.cam.civ@mail.mil FU U.S. National Science Foundation (NSF) Division of Computing and Communication Foundations [0916180]; NSF Division of Computer and Network Systems [0917008, 1346600] FX This work was supported in part by the U.S. National Science Foundation (NSF) Division of Computing and Communication Foundations under Grant 0916180 and in part by the NSF Division of Computer and Network Systems under Grant 0917008 and Grant 1346600. This paper was presented in part at the IEEE International Conference on Communications, Kyoto, Japan, June 5-9, 2011, and at the IEEE Global Communications Conference, Houston, TX, USA, December 5-9, 2011. The review of this paper was coordinated by Prof. Y. Zhang. NR 11 TC 2 Z9 2 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9545 EI 1939-9359 J9 IEEE T VEH TECHNOL JI IEEE Trans. Veh. Technol. PD OCT PY 2014 VL 63 IS 8 BP 3867 EP 3874 DI 10.1109/TVT.2014.2309115 PG 8 WC Engineering, Electrical & Electronic; Telecommunications; Transportation Science & Technology SC Engineering; Telecommunications; Transportation GA AS2BF UT WOS:000344083300033 ER PT J AU Clayton, JD AF Clayton, J. D. TI SHOCK COMPRESSION OF METAL CRYSTALS: A COMPARISON OF EULERIAN AND LAGRANGIAN ELASTIC-PLASTIC THEORIES SO INTERNATIONAL JOURNAL OF APPLIED MECHANICS LA English DT Article DE Elasticity; plasticity; shock physics; crystals; metals ID FINITE STRAIN THEORY; NONLINEAR ANISOTROPIC DESCRIPTION; SINGLE-CRYSTALS; WAVE-PROPAGATION; THERMOMECHANICAL RESPONSE; CONSTITUTIVE RELATIONS; HIGH-PRESSURE; SOLIDS; DEFORMATION; CONSTANTS AB An unconventional nonlinear elastic theory is advocated for solids undergoing large compression as may occur in shock loading. This theory incorporates an Eulerian strain measure, in locally unstressed material coordinates. Analytical predictions of this theory and conventional Lagrangian theory for elastic shock stress in anisotropic single crystals of aluminum, copper and magnesium are compared. Eulerian solutions demonstrate greater accuracy compared to atomic simulation (aluminum) and faster convergence with increasing order of elastic constants entering the internal energy. A thermomechanical framework incorporating this Eulerian strain and accounting for elastic and plastic deformations is outlined in parallel with equations for Lagrangian finite strain crystal plasticity. For several symmetric crystal orientations, predicted values of volumetric compression at the Hugoniot elastic limit of the two theories begin to differ substantially when octahedral or prismatic slip system strengths exceed about 1% of the shear modulus. Predicted pressures differ substantially for volumetric compression in excess of 5%. Predictions of Eulerian theory are closer to experimental shock data for aluminum, copper, and magnesium polycrystals. C1 US Army, Res Lab, RDRL WMP C, Aberdeen Proving Ground, MD 21005 USA. RP Clayton, JD (reprint author), US Army, Res Lab, RDRL WMP C, Aberdeen Proving Ground, MD 21005 USA. EM jclayton@arl.army.mil RI Clayton, John/C-7760-2009 NR 58 TC 3 Z9 3 U1 1 U2 14 PU IMPERIAL COLLEGE PRESS PI LONDON PA 57 SHELTON ST, COVENT GARDEN, LONDON WC2H 9HE, ENGLAND SN 1758-8251 EI 1758-826X J9 INT J APPL MECH JI Int. J. Appl. Mech. PD OCT PY 2014 VL 6 IS 5 AR 1450048 DI 10.1142/S1758825114500483 PG 29 WC Mechanics SC Mechanics GA AS4GG UT WOS:000344230900001 ER PT J AU Marple, R Ling, C Pollack, J AF Marple, Ronald Ling, Catherine Pollack, Jacquelyn TI Clinical Case Study of Syphilis: Another Example of the "Great Imitator" SO JNP-JOURNAL FOR NURSE PRACTITIONERS LA English DT Article DE Great Imitator; military; secondary syphilis; sexually transmitted disease; treponemal and nontreponemal tests ID JARISCH-HERXHEIMER REACTION; NEUROSYPHILIS; MEN AB Secondary syphilis is one of the more difficult sexually transmitted diseases to diagnose because it can resemble several other, more benign diseases. Thus, it is sometimes referred to as the "Great Imitator." In this article we describe a case of syphilis in an active-duty soldier who did not have the typical signs and symptoms of secondary syphilis. Because secondary syphilis can be difficult to identify, and because untreated secondary syphilis may progress to the debilitating and deadly tertiary stage, we present a basic strategy for diagnosing secondary syphilis. C1 [Marple, Ronald] US Army, Washington, DC 20310 USA. [Marple, Ronald] Natl Training Ctr, Ft Irwin, CA USA. [Ling, Catherine] Univ Hlth Sci, Uniformed Serv, Daniel K Inouye Grad Sch Nursing, Bethesda, MD USA. [Pollack, Jacquelyn] Epidemiol & Dis Clin, Ft Bragg, NC USA. RP Marple, R (reprint author), US Army, Washington, DC 20310 USA. EM ronald.t.marple.mil@mail.mil NR 27 TC 0 Z9 0 U1 1 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1555-4155 EI 1878-058X J9 JNP-J NURSE PRACT JI JNP-J. Nurse Pract. PD OCT PY 2014 VL 10 IS 9 BP 125 EP 132 DI 10.1016/j.nurpra.2014.07.006 PG 8 WC Nursing SC Nursing GA AS4BY UT WOS:000344219600018 ER PT J AU DiTusa, C Kozar, MP Pybus, B Sousa, J Berman, J Gettayacamin, M Im-Erbsin, R Tungtaeng, A Ohrt, C AF DiTusa, Charles Kozar, Michael P. Pybus, Brandon Sousa, Jason Berman, Jonathan Gettayacamin, Montip Im-erbsin, Rawiwan Tungtaeng, Anchalee Ohrt, Colin TI Causal Prophylactic Efficacy of Primaquine, Tafenoquine, and Atovaquone-Proguanil Against Plasmodium cynomolgi in a Rhesus Monkey Model SO JOURNAL OF PARASITOLOGY LA English DT Article ID ANTIMALARIAL AB Since the 1940s, the large animal model to assess novel causal prophylactic antimalarial agents has been the Plasmodium cynomolgi sporozoite-infected Indian-origin rhesus monkey. In 2009 the model was reassessed with 3 clinical standards: primaquine (PQ), tafenoquine (TQ), and atovaquone-proguanil. Both control monkeys were parasitemic on day 8 post-sporozoite inoculation on day 0. Primaquine at 1.78 mg base/kg/day on days (-1) to 8 protected 1 monkey and delayed parasitemia patency of the other monkey to day 49. Tafenoquine at 6 mg base/kg/day on days (-1) to 1 protected both monkeys. However, atovaquone-proguanil at 10 mg atovaquone/kg/day on days (-1) to 8 did not protect either monkey and delayed patency only to days 18-19. Primaquine and TQ at the employed regimens are proposed as appropriate doses of positive control drugs for the model at present. C1 [DiTusa, Charles; Kozar, Michael P.; Pybus, Brandon; Sousa, Jason; Berman, Jonathan; Ohrt, Colin] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Gettayacamin, Montip; Im-erbsin, Rawiwan; Tungtaeng, Anchalee] USAMC AFRIMS, Dept Vet Med, Bangkok 10400, Thailand. RP DiTusa, C (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. EM charles.a.ditusa.mil@mail.mil NR 13 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC PARASITOLOGISTS PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0022-3395 EI 1937-2345 J9 J PARASITOL JI J. Parasitol. PD OCT PY 2014 VL 100 IS 5 BP 671 EP 673 DI 10.1645/13-480.1 PG 3 WC Parasitology SC Parasitology GA AS3EM UT WOS:000344159300016 PM 24780070 ER PT J AU Sherrill, WM Johnson, EC Banning, JE AF Sherrill, William M. Johnson, Eric C. Banning, Joseph E. TI A Method for the Synthesis of Tetranitroglycoluril from Imidazo-[4,5-d]-imidazoles with Loss of Dinitrogen Oxide SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE Tetranitroglycoluril; Sorguyl; TNGU ID QUANTUM-MECHANICAL CALCULATIONS; HEATS AB A new method for the preparation of tetranitroglycoluril (TNGU, Sorguyl) is described, in which imidazo-[4,5-d]-imidazoles are nitrated with the elimination of N2O to generate TNGU. This method of TNGU synthesis results in material that is less sensitive than material produced with alternative routes. Additionally, a new spherical morphology of TNGU is disclosed. This morphology exhibits an even higher resistance to external insult even than material synthesized with the new method. C1 [Sherrill, William M.; Banning, Joseph E.] US Army Res Lab ARL, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Johnson, Eric C.] Bowhead Sci & Technol, Belcamp, MD 21017 USA. RP Sherrill, WM (reprint author), US Army Res Lab ARL, Weap & Mat Res Directorate, Bldg 1119B Spesutie Isl Rd, Aberdeen Proving Ground, MD 21005 USA. EM william.m.sherrill.civ@mail.mil NR 16 TC 0 Z9 0 U1 2 U2 4 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 0721-3115 EI 1521-4087 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD OCT PY 2014 VL 39 IS 5 BP 670 EP 676 DI 10.1002/prep.201400041 PG 7 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA AS0MD UT WOS:000343970200008 ER PT J AU Wright, KM Britt, TW Moore, D AF Wright, Kathleen M. Britt, Thomas W. Moore, DeWayne TI Impediments to Mental Health Treatment as Predictors of Mental Health Symptoms Following Combat SO JOURNAL OF TRAUMATIC STRESS LA English DT Article ID PERCEIVED STIGMA; TEST STATISTICS; PRIMARY-CARE; BARRIERS; SOLDIERS; VETERANS; IRAQ; CHECKLIST AB This longitudinal study examined whether impediments to mental health treatment would predict changes in mental health symptoms (posttraumatic stress disorder [PTSD] and depression) in the months following soldiers returning from combat. Three-hundred ten combat veterans completed measures of impediments to treatment and measures of PTSD and depression symptoms at 2, 3, and 4 months following a 15-month combat deployment. Structural equation modeling revealed that greater impediments (a latent variable indexed by stigma, practical barriers, and negative treatment attitudes) at 2 months predicted increased PTSD and depression symptoms from 2-3 months ( = .14) and greater impediments at 3 months predicted increased symptoms from 3-4 months ( = .26). In contrast, evidence was not obtained for the opposite causal direction of symptoms predicting higher levels of impediments at the different periods. Possible mechanisms for the predictive effects of impediments are discussed. Resumen Este estudio longitudinal examino si los impedimentos (obstaculos) al tratamiento de salud mental predicen los cambios en los sintomas de salud mental (TEPT y depresion) en los meses posteriores al retorno de combate en soldados. Un total de 310 ex combatientes completaron las medidas de impedimentos (obstaculos) para el tratamiento y las medidas de sintomas de TEPT y depresion 2, 3 y 4 meses posteriores a 15 meses de servicio de combate. El modelo de ecuacion estructural revelo que a mayores impedimentos (una variable latente indexada por estigma, barreras practicas y actitudes negativas al tratamiento) a los 2 meses, predijeron un aumento de sintomas de TEPT y depresion de 2 a 3 meses (r=.14) y mayores impedimentos a los 3 meses predijeron un aumento de los sintomas de 3 a 4 meses (r=.26). Por el contrario, no se obtuvo evidencia para el efecto causal opuesto de los sintomas prediciendo mayores niveles de impedimentos en los diferentes periodos de tiempo. Los posibles mecanismos para los efectos predictivos de los impedimentos son discutidos. C1 [Wright, Kathleen M.; Britt, Thomas W.] Walter Reed Army Inst Res, Heidelberg, Germany. [Britt, Thomas W.; Moore, DeWayne] Clemson Univ, Dept Psychol, Clemson, SC 29634 USA. RP Wright, KM (reprint author), US Army Med Res Unit, APO, AE 09042 USA. EM kathleen.wright@outlook.com NR 31 TC 0 Z9 0 U1 2 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0894-9867 EI 1573-6598 J9 J TRAUMA STRESS JI J. Trauma Stress PD OCT PY 2014 VL 27 IS 5 BP 535 EP 541 DI 10.1002/jts.21946 PG 7 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA AR9WS UT WOS:000343928000005 PM 25322883 ER PT J AU Kowalski, PC Dowben, JS Keltner, NL AF Kowalski, Peter C. Dowben, Jonathan S. Keltner, Norman L. TI Biological Perspectives Hyponatremia: A Side Effect of Psychosis SO PERSPECTIVES IN PSYCHIATRIC CARE LA English DT Article C1 [Dowben, Jonathan S.] Brooke Army Med Ctr, Pediat & Behav Hlth Serv, San Antonio, TX USA. [Keltner, Norman L.] Univ Alabama Birmingham, Birmingham, AL USA. EM nkeltner@uab.edu NR 3 TC 1 Z9 2 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0031-5990 EI 1744-6163 J9 PERSPECT PSYCHIATR C JI Perspect. Psychiatr. Care PD OCT PY 2014 VL 50 IS 4 BP 221 EP 223 DI 10.1111/ppc.12084 PG 3 WC Nursing; Psychiatry SC Nursing; Psychiatry GA AS0WM UT WOS:000343996600002 PM 25219879 ER PT J AU Chen, G Koellhoffer, JF Zak, SE Frei, JC Liu, NN Long, H Ye, W Nagar, K Pan, GH Chandran, K Dye, JM Sidhu, SS Lai, JR AF Chen, Gang Koellhoffer, Jayne F. Zak, Samantha E. Frei, Julia C. Liu, Nina Long, Hua Ye, Wei Nagar, Kaajal Pan, Guohua Chandran, Kartik Dye, John M. Sidhu, Sachdev S. Lai, Jonathan R. TI Synthetic Antibodies with a Human Framework That Protect Mice from Lethal Sudan Ebolavirus Challenge SO ACS CHEMICAL BIOLOGY LA English DT Article ID MONOCLONAL-ANTIBODIES; SCANNING MUTAGENESIS; ANTIGEN RECOGNITION; VIRUS GLYCOPROTEIN; STRUCTURAL BASIS; INFECTION; BINDING; NEUTRALIZATION; DISEASE; FUSION AB The ebolaviruses cause severe and rapidly progressing hemorrhagic fever. There are five ebolavirus species; although much is known about Zaire ebolavirus (EBOV) and its neutralization by antibodies, little is known about Sudan ebolavirus (SUDV), which is emerging with increasing frequency. Here we describe monoclonal antibodies containing a human framework that potently inhibit infection by SUDV and protect mice from lethal challenge. The murine antibody 16F6, which binds the SUDV envelope glycoprotein (GP), served as the starting point for design. Sequence and structural alignment revealed similarities between 16F6 and YADS1, a synthetic antibody with a humanized scaffold. A focused phage library was constructed and screened to impart 16F6-like recognition properties onto the YADS1 scaffold. A panel of 17 antibodies were characterized and found to have a range of neutralization potentials against a pseudotype virus infection model. Neutralization correlated with GP binding as determined by ELISA. Two of these clones, E10 and F4, potently inhibited authentic SUDV and conferred protection and memory immunity in mice from lethal SUDV challenge. E10 and F4 were further shown to bind to the same epitope on GP as 16F6 with comparable affinities. These antibodies represent strong immunotherapeutic candidates for treatment of SUDV infection. C1 [Chen, Gang; Long, Hua; Ye, Wei; Nagar, Kaajal; Pan, Guohua; Sidhu, Sachdev S.] Univ Toronto, Terrence Donnelly Ctr Cellular & Biomol Res, Banting & Best Dept Med Res, Toronto, ON M5S 3E1, Canada. [Koellhoffer, Jayne F.; Frei, Julia C.; Liu, Nina; Lai, Jonathan R.] Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA. [Chandran, Kartik] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA. [Zak, Samantha E.; Dye, John M.] US Army Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. RP Dye, JM (reprint author), US Army Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA. EM john.m.dye1.civ@mail.mil; sachdev.sidhu@utoronto.ca; jon.lai@einstein.yu.edu FU NIH [R01-AI090249, R01-AI088027, U19-AI09762]; Canadian Institutes for Health Research [MOP-93725]; JSTO-CBD Defense Threat Reduction Agency [CB3947]; NIH Medical Scientist Training Program [T32-GM007288]; NIH Cellular and Molecular Biology and Genetics Training Program [T32-GM007491] FX This work was supported by the NIH (R01-AI090249 (J.R.L.), R01-AI088027 (K.C.), and U19-AI09762), the Canadian Institutes for Health Research Grant MOP-93725 (S.S.S.), and JSTO-CBD Defense Threat Reduction Agency CB3947 (J.M.D.). J.F.K was supported in part by NIH Medical Scientist Training Program T32-GM007288, and J.C.F. by NIH Cellular and Molecular Biology and Genetics Training Program T32-GM007491. Opinions, conclusions, interpretations, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. The mention of trade names or commercial products does not constitute endorsement or recommendation for use by the Department of the Army or the Department of Defense. NR 37 TC 12 Z9 14 U1 2 U2 12 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1554-8929 EI 1554-8937 J9 ACS CHEM BIOL JI ACS Chem. Biol. PD OCT PY 2014 VL 9 IS 10 BP 2263 EP 2273 DI 10.1021/cb5006454 PG 11 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA AR3ZD UT WOS:000343526900014 PM 25140871 ER PT J AU Van de Verg, LL Venkatesan, MM AF Van de Verg, Lillian L. Venkatesan, Malabi M. TI A Shigella Vaccine Against Prevalent Serotypes SO CLINICAL INFECTIOUS DISEASES LA English DT Editorial Material DE Shigella; vaccine; O-antigen; cross-reactivity; prevalence ID FLEXNERI O-ANTIGENS; CHILDREN; MULTICENTER; PROTECTION; RESISTANCE; COUNTRIES; STRAINS; DISEASE; BURDEN C1 [Van de Verg, Lillian L.] PATH, Vaccine Dev Global Program, Washington, DC 20001 USA. [Venkatesan, Malabi M.] Walter Reed Army Inst Res, Bacterial Dis Branch, Silver Spring, MD USA. RP Van de Verg, LL (reprint author), PATH, Vaccine Dev Global Program, Enter Vaccine Initiat, 455 Massachusetts Ave NW, Washington, DC 20001 USA. EM lvandeverg@path.org NR 13 TC 4 Z9 4 U1 3 U2 8 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD OCT 1 PY 2014 VL 59 IS 7 BP 942 EP 943 DI 10.1093/cid/ciu471 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AR2JY UT WOS:000343411900006 PM 24958237 ER PT J AU Witzel, J AF Witzel, John TI Recreating the Double Slit Experiment at Home SO IEEE INSTRUMENTATION & MEASUREMENT MAGAZINE LA English DT Editorial Material C1 [Witzel, John] Paladin South, Kandahar, Afghanistan. [Witzel, John] US Army, Washington, DC USA. RP Witzel, J (reprint author), Paladin South, Kandahar, Afghanistan. EM john.witzel@gmail.com NR 0 TC 0 Z9 0 U1 1 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1094-6969 EI 1941-0123 J9 IEEE INSTRU MEAS MAG JI IEEE Instrum. Meas. Mag. PD OCT PY 2014 VL 17 IS 5 BP 34 EP 35 PG 2 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA AR6OR UT WOS:000343703400008 ER PT J AU Shadmand, MB Balog, RS Johnson, MD AF Shadmand, Mohammad B. Balog, Robert S. Johnson, Melanie D. TI Predicting Variability of High-Penetration Photovoltaic Systems in a Community Microgrid by Analyzing High-Temporal Rate Data SO IEEE TRANSACTIONS ON SUSTAINABLE ENERGY LA English DT Article DE Distributed PV systems; microgrid; photovoltaic (PV); PV-storage system; smart grid; variability analysis ID BATTERY ENERGY-STORAGE; STANDALONE MICROGRIDS; SOLAR IRRADIANCE; OPERATION; NETWORK AB Interest in renewable energy sources continues to gain popularity. However, a major fundamental limitation exists that prevents widespread adoption: variability of electricity generated. Distributed generation (DG) grid-tied photovoltaic (PV) systems with centralized battery back-up can mitigate the variability of PV systems and be optimized to reduce cost by analyzing high-temporal rate data. Thus, it is an attractive system to meet "go green" mandates, while also providing reliable electricity. The focus of this paper is to analyze the variability of a high-penetration PV scenario when incorporated into the microgrid concept. The proposed system design approach is based on high-temporal rate instead of the more commonly used hourly data rate. The methodology presented in this paper employs a technoeconomic approach to determine the optimal system design to guarantee reliable electricity supply with lowest investment. The proposed methodology is used to demonstrate that the variability of the PV resource can be quantified by determining the number of PV arrays and their corresponding distance in the microgrid and then mitigate with optimized storage. C1 [Shadmand, Mohammad B.; Balog, Robert S.] Texas A&M Univ, Dept Elect & Comp Engn, Renewable Energy & Adv Power Elect Res Lab, College Stn, TX 77843 USA. [Johnson, Melanie D.] US Army Engineer Res & Dev Ctr, Champaign, IL 61822 USA. RP Shadmand, MB (reprint author), Texas A&M Univ, Dept Elect & Comp Engn, Renewable Energy & Adv Power Elect Res Lab, College Stn, TX 77843 USA. EM mohamadshadmand@gmail.com; robert.balog@ieee.org; melanie.d.johnson@usace.army.mil FU Texas State Energy Conservation Office FX Funding for the 27.6 kW photovoltaic system studied in this paper at Texas A&M University, College Station, TX, USA, was provided by a grant from the Texas State Energy Conservation Office. NR 38 TC 3 Z9 3 U1 0 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1949-3029 J9 IEEE T SUSTAIN ENERG JI IEEE Trans. Sustain. Energy PD OCT PY 2014 VL 5 IS 4 BP 1434 EP 1442 DI 10.1109/TSTE.2014.2345745 PG 9 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Energy & Fuels; Engineering, Electrical & Electronic SC Science & Technology - Other Topics; Energy & Fuels; Engineering GA AR8OJ UT WOS:000343834200045 ER PT J AU Ponticorvo, A Burmeister, DM Yang, B Choi, B Christy, RJ Durkin, AJ AF Ponticorvo, Adrien Burmeister, David M. Yang, Bruce Choi, Bernard Christy, Robert J. Durkin, Anthony J. TI Quantitative assessment of graded burn wounds in a porcine model using spatial frequency domain imaging (SFDI) and laser speckle imaging (LSI) SO BIOMEDICAL OPTICS EXPRESS LA English DT Article ID DEPTH ASSESSMENT; PROGRESSION; STASIS; INJURY; ZONE AB Accurate and timely assessment of burn wound severity is a critical component of wound management and has implications related to course of treatment. While most superficial burns and full thickness burns are easily diagnosed through visual inspection, burns that fall between these extremes are challenging to classify based on clinical appearance. Because of this, appropriate burn management may be delayed, increasing the risk of scarring and infection. Here we present an investigation that employs spatial frequency domain imaging (SFDI) and laser speckle imaging (LSI) as non-invasive technologies to characterize in-vivo burn severity. We used SFDI and LSI to investigate controlled burn wounds of graded severity in a Yorkshire pig model. Burn wounds were imaged starting at one hour after the initial injury and daily at approximately 24, 48 and 72 hours post burn. Biopsies were taken on each day in order to correlate the imaging data to the extent of burn damage as indicated via histological analysis. Changes in reduced scattering coefficient and blood flow could be used to categorize burn severity as soon as one hour after the burn injury. The results of this study suggest that SFDI and LSI information have the potential to provide useful metrics for quantifying the extent and severity of burn injuries. (C) 2014 Optical Society of America C1 [Ponticorvo, Adrien; Yang, Bruce; Choi, Bernard; Durkin, Anthony J.] Univ Calif Irvine, Beckman Laser Inst, Irvine, CA 92617 USA. [Ponticorvo, Adrien; Yang, Bruce; Choi, Bernard; Durkin, Anthony J.] Univ Calif Irvine, Med Clin, Irvine, CA 92617 USA. [Choi, Bernard] Univ Calif Irvine, Dept Biomed Engn, Irvine, CA 92697 USA. [Burmeister, David M.; Christy, Robert J.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Ponticorvo, A (reprint author), Univ Calif Irvine, Beckman Laser Inst, 1002 Hlth Sci Rd East, Irvine, CA 92617 USA. EM adurkin@uci.edu OI Durkin, Anthony/0000-0001-9124-6388 FU Beckman Foundation; NIH [P41EB015890, UL1 TR000148]; Military Medical Photonics Program (AFOSR) [FA9550-10-1-0538] FX We gratefully acknowledge support from the Beckman Foundation and the NIH, including P41EB015890 (A Biomedical Technology Resource), UL1 TR000148 and the Military Medical Photonics Program (AFOSR FA9550-10-1-0538). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. NR 45 TC 15 Z9 16 U1 2 U2 16 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 2156-7085 J9 BIOMED OPT EXPRESS JI Biomed. Opt. Express PD OCT 1 PY 2014 VL 5 IS 10 BP 3467 EP 3481 DI 10.1364/BOE.5.003467 PG 15 WC Biochemical Research Methods; Optics; Radiology, Nuclear Medicine & Medical Imaging SC Biochemistry & Molecular Biology; Optics; Radiology, Nuclear Medicine & Medical Imaging GA AQ9BI UT WOS:000343135200017 PM 25360365 ER PT J AU Li, LL Holthoff, EL Shaw, LA Burgner, CB Turner, KL AF Li, Lily L. Holthoff, Ellen L. Shaw, Lucas A. Burgner, Christopher B. Turner, Kimberly L. TI Noise Squeezing Controlled Parametric Bifurcation Tracking of MIP-Coated Microbeam MEMS Sensor for TNT Explosive Gas Sensing SO JOURNAL OF MICROELECTROMECHANICAL SYSTEMS LA English DT Article DE Bifurcation; mass sensing; noise squeezing ID MOLECULARLY IMPRINTED POLYMERS; CANTILEVER ARRAY; RESONANCE; AMPLIFICATION; OSCILLATOR; FREQUENCY; SYSTEMS; LIMITS AB This paper reports real-time explosive gas sensing (DNT) in atmospheric pressure utilizing the noise squeezing effect that occurs before a bifurcation event. A noise-squeezing controller based on the statistics of phase noise is implemented using high-speed LabVIEW field programmable gated array. A high frequency TNT-molecularly imprinted fixed-fixed microbeam sensor utilizes this nontraditional sensing strategy and performs DNT sensing at various concentrations. Experiments are conducted using both noise-based and sweep-based bifurcation tracking for a direct comparison. Results demonstrate noise-based bifurcation tracking is not only capable of performing reliable frequency tracking, but also show the method is superior to the bifurcation sweep-based tracking. Over three orders of magnitude improvement in acquisition rate is achieved, and as a result, confidence and precision on bifurcation frequency estimation is significantly improved over the bifurcation sweep tracking method, enabling DNT sensing at concentrations much below sub-ppb (parts-per-billion) level. [2013-0339] C1 [Li, Lily L.; Shaw, Lucas A.; Burgner, Christopher B.; Turner, Kimberly L.] Univ Calif Santa Barbara, Santa Barbara, CA 93106 USA. [Holthoff, Ellen L.] Army Res Lab, Sensors & Devices Directorate, Adelphi, MD 20783 USA. RP Li, LL (reprint author), Univ Calif Santa Barbara, Santa Barbara, CA 93106 USA. EM lily@engr.ucsb.edu; ellen.l.holthoff.civ@mail.mil; lukeshaw2@gmail.com; christopher.burgner@gmail.com; turner@engr.ucsb.edu FU Institute for Collaborative Biotechnologies through the U.S. Army Research Office [W911NF-09-0001] FX Manuscript received November 15, 2013; revised January 27, 2014; accepted February 27, 2014. Date of publication March 20, 2014; date of current version September 29, 2014. This work was supported by the Institute for Collaborative Biotechnologies under Grant W911NF-09-0001 through the U.S. Army Research Office. Subject Editor A. Seshia. NR 34 TC 3 Z9 3 U1 9 U2 27 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1057-7157 EI 1941-0158 J9 J MICROELECTROMECH S JI J. Microelectromech. Syst. PD OCT PY 2014 VL 23 IS 5 BP 1228 EP 1236 DI 10.1109/JMEMS.2014.2310206 PG 9 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Instruments & Instrumentation; Physics, Applied SC Engineering; Science & Technology - Other Topics; Instruments & Instrumentation; Physics GA AR1CL UT WOS:000343318500024 ER PT J AU Byrne, SM Mulcahy, S Torres, M Catlin, A AF Byrne, Susan M. Mulcahy, Svetlana Torres, Myra Catlin, Anita TI Reconsidering Do-Not-Resuscitate Orders in the Perioperative Setting SO JOURNAL OF PERIANESTHESIA NURSING LA English DT Article DE anesthesia ethics; do not resuscitate; perioperative; palliative care ID CARE AB Many of our elderly have now signed advance directives or physicians' order sets of life-sustaining treatment forms. Frequently, choices have been made for no life-sustaining interventions at the end of life or do-not-resuscitate (DNR) orders. As the proportion of elderly grows and more patients seek surgical intervention for comfort or to improve their quality of life, the medical and ethical issues of DNR orders in the perioperative setting become increasingly more complex. Many health care providers neither recognize the complexity and significance of the DNR order during the perioperative period nor have hospitals established actions toward resolution of this situation. This article will discuss how this complex issue should be explored, definitions established, and positions recommended. C1 [Byrne, Susan M.] Kaiser Permanente Med Ctr, Cochair Eth Comm, San Rafael, CA 94903 USA. [Mulcahy, Svetlana] Mendocino Cast Clin, Ft Bragg, CA USA. [Torres, Myra] John Muir Hosp, CV Progress Care Unit, Concord, CA USA. [Torres, Myra] Ohlone Coll Nursing, Neward, CA USA. [Catlin, Anita] Kaiser Santa Rosa, Kaiser Vallejo Res Council, Cochair Eth Comm, Vallejo, CA USA. RP Byrne, SM (reprint author), Kaiser Permanente Med Ctr, 99 Monticello Rd, San Rafael, CA 94903 USA. EM suzie.byrne@kp.org NR 18 TC 2 Z9 2 U1 1 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1089-9472 EI 1532-8473 J9 J PERIANESTH NURS JI J. PeriAnesthesia Nurs. PD OCT PY 2014 VL 29 IS 5 BP 354 EP 360 DI 10.1016/j.jopan.2013.05.016 PG 7 WC Nursing SC Nursing GA AQ7TH UT WOS:000343021600004 PM 25261138 ER PT J AU Tober, RL Bruno, JD Suchalkin, S Belenky, G AF Tober, Richard L. Bruno, John D. Suchalkin, Sergei Belenky, Gregory TI Zigzag modes in quantum cascade laser emission spectra SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS LA English DT Article ID ROOM-TEMPERATURE; DOT LASERS; MU-M; LOCKING; FACET AB We present emission spectra obtained from ridge waveguide quantum cascade (QC) lasers with atypical periodic features that result from optical modes that suffer total internal sidewall reflections and traverse zigzag paths along the length of the waveguide structure. These "zigzag" modes are equally spaced, in frequency, about the single lasing mode that arises at threshold. Moreover, they only exist at relatively low injection currents and with increasing current yield to the broadband Fabry-Perot modes that typically comprise the complicated spectra of QC lasers. A straightforward geometric analysis shows a clear correspondence between the zigzag modes and parameters useful for characterizing the quality of the laser waveguide structure. (C) 2014 Optical Society of America C1 [Tober, Richard L.] Army Res Lab, Adelphi, MD 20783 USA. [Bruno, John D.] Maxion Technol Inc, Jessup, MD 20794 USA. [Suchalkin, Sergei; Belenky, Gregory] SUNY Stony Brook, Dept Elect & Comp Engn, Stony Brook, NY 11794 USA. RP Tober, RL (reprint author), Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM richard.l.tober.civ@mail.mil FU Army Research Office [W911NF-11-1-0109] FX This work was supported in part by the Army Research Office under Contract No. W911NF-11-1-0109. NR 27 TC 1 Z9 1 U1 2 U2 12 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0740-3224 EI 1520-8540 J9 J OPT SOC AM B JI J. Opt. Soc. Am. B-Opt. Phys. PD OCT PY 2014 VL 31 IS 10 BP 2399 EP 2403 DI 10.1364/JOSAB.31.002399 PG 5 WC Optics SC Optics GA AR0FX UT WOS:000343245800030 ER PT J AU Das, S Zhang, W Demarteau, M Hoffmann, A Dubey, M Roelofs, A AF Das, Saptarshi Zhang, Wei Demarteau, Marcel Hoffmann, Axel Dubey, Madan Roelofs, Andreas TI Tunable Transport Gap in Phosphorene SO NANO LETTERS LA English DT Article DE Phosphorene; transport gap; field effect transistor; mobility ID FIELD-EFFECT TRANSISTORS; MOS2 TRANSISTORS; MULTILAYER MOS2; GRAPHENE; CONTACTS AB In this article, we experimentally demonstrate that the transport gap of phosphorene can be tuned monotonically from similar to 0.3 to similar to 1.0 eV when the flake thickness is scaled down from bulk to a single layer. As a consequence, the ON current, the OFF current, and the current ON/OFF ratios of phosphorene field effect transistors (FETs) were found to be significantly impacted by the layer thickness. The transport gap was determined from the transfer characteristics of phosphorene FETs using a robust technique that has not been reported before. The detailed mathematical model is also provided. By scaling the thickness of the gate oxide, we were also able to demonstrate enhanced ambipolar conduction in monolayer and few layer phosphorene FETs. The asymmetry of the electron and the hole current was found to be dependent on the layer thickness that can be explained by dynamic changes of the metal Fermi level with the energy band of phosphorene depending on the layer number. We also extracted the Schottky barrier heights for both the electron and the hole injection as a function of the layer thickness. Finally, we discuss the dependence of field effect hole mobility of phosphorene on temperature and carrier concentration. C1 [Das, Saptarshi; Roelofs, Andreas] Argonne Natl Lab, Ctr Nanoscale Mat, Argonne, IL 60439 USA. [Zhang, Wei; Hoffmann, Axel] Argonne Natl Lab, Mat Sci Div, Argonne, IL 60439 USA. [Demarteau, Marcel] Argonne Natl Lab, Div High Energy Phys, Argonne, IL 60439 USA. [Dubey, Madan] US Army Res Lab, Adelphi, MD 20783 USA. RP Das, S (reprint author), Argonne Natl Lab, Ctr Nanoscale Mat, 9700 S Cass Ave, Argonne, IL 60439 USA. EM das.sapt@gmail.com RI Zhang, Wei/G-1523-2012; Hoffmann, Axel/A-8152-2009; Roelofs, Andreas/H-1742-2011 OI Zhang, Wei/0000-0002-5878-3090; Hoffmann, Axel/0000-0002-1808-2767; Roelofs, Andreas/0000-0003-4141-3082 FU U.S. Department of Energy, Office of Science, Materials Science and Engineering Division; DOE Office of High Energy Physics under DoE [DE-AC02-06CH11357]; U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-06CHI1357] FX The work by W.Z. and A.H. was supported by the U.S. Department of Energy, Office of Science, Materials Science and Engineering Division. The work of Saptarshi Das is supported by the DOE Office of High Energy Physics under DoE contract number DE-AC02-06CH11357. Use of the Center for Nanoscale Materials was supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No. DE-AC02-06CHI1357. NR 23 TC 176 Z9 177 U1 25 U2 226 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1530-6984 EI 1530-6992 J9 NANO LETT JI Nano Lett. PD OCT PY 2014 VL 14 IS 10 BP 5733 EP 5739 DI 10.1021/nl5025535 PG 7 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA AQ7RH UT WOS:000343016400040 PM 25111042 ER PT J AU Sarkar, S Kanchibotla, B Nelson, JD Edwards, JD Anderson, J Tepper, GC Bandyopadhyay, S AF Sarkar, S. Kanchibotla, B. Nelson, J. D. Edwards, J. D. Anderson, J. Tepper, G. C. Bandyopadhyay, S. TI Giant Increase in the Metal-Enhanced Fluorescence of Organic Molecules in Nanoporous Alumina Templates and Large Molecule-Specific Red/Blue-Shift of the Fluorescence Peak SO NANO LETTERS LA English DT Article DE Metal-enhanced fluorescence; surface plasmons; plasmonic waveguides; red/blue shift; chemical sensing and biosensing ID WAVE-GUIDES AB The fluorescence of organic fluorophore molecules is enhanced when they are placed in contact with certain metals (Al, Ag, Cu, Au, etc.) whose surface plasmon waves couple into the radiative modes of the molecules and increase the radiative efficiency. Here, we report a hitherto unknown size dependence of this metal-enhanced fluorescence (MEF) effect in the nanoscale. When the molecules are deposited in nanoporous anodic alumina films with exposed aluminum at the bottom of the pores, they form organic nanowires standing on aluminum nanoparticles whose plasmon waves have much larger amplitudes. This increases the MEF strongly, resulting in several orders of magnitude increase in the fluorescence intensity of the organic fluorophores. The increase in intensity shows an inverse superlinear dependence on nanowire diameter because the nanowires also act as plasmonic "waveguides" that concentrate the plasmons and increase the coupling of the plasmons with the radiative modes of the molecules. Furthermore, if the nanoporous template housing the nanowires has built-in electric fields due to space charges, a strong molecule-specific red- or blue-shift is induced in the fluorescence peak owing to a renormalization of the dipole moment of the molecule. This can be exploited to detect minute amounts of target molecules in a mixture using their optical signature (fluorescence) despite the presence of confounding background signals. It can result in a unique new technology for biosensing and chemical sensing. C1 [Sarkar, S.; Tepper, G. C.] Virginia Commonwealth Univ, Dept Mech & Nucl Engn, Richmond, VA 23284 USA. [Kanchibotla, B.; Bandyopadhyay, S.] Virginia Commonwealth Univ, Dept Elect & Comp Engn, Richmond, VA 23284 USA. [Nelson, J. D.; Edwards, J. D.; Anderson, J.] US Army Engineer Res & Dev Ctr, Alexandria, VA 22315 USA. RP Bandyopadhyay, S (reprint author), Virginia Commonwealth Univ, Dept Elect & Comp Engn, Med Coll Virginia Campus, Richmond, VA 23284 USA. EM sbandy@vcu.edu NR 18 TC 4 Z9 4 U1 8 U2 76 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1530-6984 EI 1530-6992 J9 NANO LETT JI Nano Lett. PD OCT PY 2014 VL 14 IS 10 BP 5973 EP 5978 DI 10.1021/nl502990h PG 6 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA AQ7RH UT WOS:000343016400075 PM 25233371 ER PT J AU Morris, DM Gemeinhardt, TR Gosch, NJC Jensen, DE AF Morris, D. M. Gemeinhardt, T. R. Gosch, N. J. C. Jensen, D. E. TI WATER QUALITY DURING TWO HIGH-FLOW YEARS ON THE LOWER MISSOURI RIVER: THE EFFECTS OF RESERVOIR AND TRIBUTARY CONTRIBUTIONS SO RIVER RESEARCH AND APPLICATIONS LA English DT Article DE nutrients; water quality; flood; large rivers ID MISSISSIPPI RIVER; EXAMPLE; NITRATE; BASIN AB Complex socioeconomic and ecological issues, ranging from impaired streams to Gulf of Mexico hypoxia, have made nutrient management an increasingly important issue across the USA. High flows during 2010 and 2011 provided a unique opportunity to investigate trends in discharge, total nitrogen, nitrate/nitrite, total phosphorus, ortho-phosphorus, suspended sediment and total suspended solids during two distinct high-flow years on the Missouri River. We compared collections taken during 2010 and 2011 at 12 lower Missouri River locations (river kilometers 1212 to 71) and 22 Missouri River tributary locations. During 2011, average concentrations for all sampled parameters were significantly lower, despite significantly higher total discharge, than 2010 concentrations. Differences in water chemistry between years are likely attributed to the primary source of water. Tributary inflow created high flows during 2010, whereas record releases from Gavins Point Dam created high flows during 2011. Analysis of flow estimated the contribution of these releases at each site and revealed strong positive relationships between the percentage of estimated tributary flow at each site and the concentrations of total nitrogen, total phosphorus and total suspended solids. These monitoring efforts underline the contrasting impacts that tributary streams and reservoir releases have on nutrient export of the Missouri River during high-flow events and reveal a larger trend of increased nutrient concentrations as the proportion of Missouri River tributary flow increased. Published 2013. This article is a U. S. Government work and is in the public domain in the USA. River Research and Applications published by John Wiley & Sons, Ltd. C1 [Morris, D. M.; Gemeinhardt, T. R.; Gosch, N. J. C.] US Army Corps Engineers, Kansas City, MO 64106 USA. [Jensen, D. E.] US Army Corps Engineers, Omaha, NE USA. RP Morris, DM (reprint author), US Army Corps Engineers, 601 East 12th St, Kansas City, MO 64106 USA. EM Dane.M.Morris@usace.army.mil FU USACE Kansas City District FX We thank Chance Bitner, George Williams, Allen Chestnut and Kellie Bergman for providing valuable comments and suggestions. This study was funded by the USACE Kansas City District. The contents of this report are not to be used for advertising, publication or promotional purposes. Reference to trade names does not imply endorsement by the US Government. All product names and trademarks cited are the property of their respective owners. The authors do not have any potential sources of conflict of interest with the publication of this report. The findings of this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents. NR 30 TC 1 Z9 1 U1 5 U2 27 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1535-1459 EI 1535-1467 J9 RIVER RES APPL JI River Res. Appl. PD OCT PY 2014 VL 30 IS 8 BP 1024 EP 1033 DI 10.1002/rra.2693 PG 10 WC Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA AQ7YY UT WOS:000343038000008 ER PT J AU Kobylinski, KC About, H Foy, BD Clements, A Adisakwattana, P Swierczewski, BE Richardson, JH AF Kobylinski, Kevin C. About, Haoues Foy, Brian D. Clements, Archie Adisakwattana, Poom Swierczewski, Brett E. Richardson, Jason H. TI Rationale for the Coadministration of Albendazole and Ivermectin to Humans for Malaria Parasite Transmission Control SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID SOIL-TRANSMITTED HELMINTHS; PLASMODIUM-FALCIPARUM INFECTION; NEGLECTED TROPICAL DISEASES; ELIMINATE LYMPHATIC FILARIASIS; COMMUNITY-DIRECTED TREATMENT; INTESTINAL HELMINTH; ASCARIS-LUMBRICOIDES; TRICHURIS-TRICHIURA; PREGNANT-WOMEN; MICROTUBULE INHIBITORS AB Recently there have been calls for the eradication of malaria and the elimination of soil-transmitted helminths (STHs). Malaria and STHs overlap in distribution, and STH infections are associated with increased risk for malaria. Indeed, there is evidence that suggests that STH infection may facilitate malaria transmission. Malaria and STH coinfection may exacerbate anemia, especially in pregnant women, leading to worsened child development and more adverse pregnancy outcomes than these diseases would cause on their own. Ivermectin mass drug administration (MDA) to humans for malaria parasite transmission suppression is being investigated as a potential malaria elimination tool. Adding albendazole to ivermectin MDAs would maximize effects against STHs. A proactive, integrated control platform that targets malaria and STHs would be extremely cost-effective and simultaneously reduce human suffering caused by multiple diseases. This paper outlines the benefits of adding albendazole to ivermectin MDAs for malaria parasite transmission suppression. C1 [Kobylinski, Kevin C.] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [About, Haoues; Foy, Brian D.] Colorado State Univ, Dept Microbiol Immunol & Pathol, Arthropod Borne & Infect Dis Lab, Ft Collins, CO 80523 USA. [Clements, Archie] Australian Natl Univ, Coll Med Biol & Environm, Res Sch Populat Hlth, Canberra, ACT, Australia. [Adisakwattana, Poom] Mahidol Univ, Fac Trop Med, Dept Helminthol, Bangkok, Thailand. [Swierczewski, Brett E.] Walter Reed Army Inst Res, Bacterial Dis Branch, Silver Spring, MD USA. [Richardson, Jason H.] Armed Forces Pest Management Board, Silver Spring, MD USA. RP Kobylinski, KC (reprint author), Armed Forces Res Inst Med Sci, Dept Entomol, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM kobylinskikevin@yahoo.com; Haoues@rams.colostate.edu; brian.foy@colostate.edu; archie.clements@anu.edu; poom.adi@mahidol.ac.th; brett.e.swierczewski.mil@mail.mil; Jason.h.richardson.mil@mail.mil RI Foy, Brian/E-6230-2017; Alout, Haoues/N-9556-2016 OI Foy, Brian/0000-0002-9117-203X; Alout, Haoues/0000-0001-7917-2697 FU Military Infectious Disease Research Program; National Institutes of Health [1R01AI094349-01A1] FX Funding for laboratory investigation was provided by the Military Infectious Disease Research Program. Part of this research was performed while K.C.K. held a National Research Council Research Associateship Award at the Walter Reed Army Institute of Research. H.A. and B.D.F. acknowledge funding from National Institutes of Health Grant 1R01AI094349-01A1 and thank Benjamin Krajacich, Jacob Meyers, Nathan Grubaugh, Massamba Sylla, Moussa Sarr, Lawrence Fakoli III, Fatorma Bolay, and Roch Dabire for their work facilitating the field collections. NR 113 TC 4 Z9 4 U1 3 U2 14 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 2014 VL 91 IS 4 BP 655 EP 662 DI 10.4269/ajtmh.14-0187 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA AQ6XQ UT WOS:000342957600001 PM 25070998 ER PT J AU Petz, LN Turell, MJ Padilla, S Long, LS Reinbold-Wasson, DD Smith, DR O'Guinn, ML Melanson, VR Lee, JS AF Petz, Lawrence N. Turell, Michael J. Padilla, Susana Long, Lewis S. Reinbold-Wasson, Drew D. Smith, Darci R. O'Guinn, Monica L. Melanson, Vanessa R. Lee, John S. TI Development of Conventional and Real-Time Reverse Transcription Polymerase Chain Reaction Assays to Detect Tembusu Virus in Culex tarsalis Mosquitoes SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID MEDIATED ISOTHERMAL AMPLIFICATION; RT-PCR; RAPID DETECTION; FIELD DETECTION; ENCEPHALITIS; FLAVIVIRUS; CHINA; ISOLATIONS; THAILAND; DUCKS AB Tembusu virus (TMUV) is an important emerging arthropod-borne virus that may cause encephalitis in humans and has been isolated in regions of southeast Asia, including Malaysia, Thailand, and China. Currently, detection and identification of TMUV are limited to research laboratories, because quantitative rapid diagnostic assays for the virus do not exist. We describe the development of sensitive and specific conventional and real-time quantitative reverse transcription polymerase chain reaction assays for detecting TMUV RNA in infected cell culture supernatant and Culex tarsalis mosquitoes. We used this assay to document the replication of TMUV in Cx. tarsalis, where titers increased 1,000-fold 5 days after inoculation. These assays resulted in the detection of virus-specific RNA in the presence of copurified mosquito nucleic acids. The use of these rapid diagnostic assays may have future applications for field pathogen surveillance and may assist in early detection, diagnosis, and control of the associated arthropod-borne pathogens. C1 [Petz, Lawrence N.] US Army, Inst Surg Res, Battlefield Pain Management Res Program, Ft Sam Houston, MD USA. [Turell, Michael J.; Padilla, Susana] US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Long, Lewis S.; Melanson, Vanessa R.] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD USA. [Reinbold-Wasson, Drew D.] US Army, Publ Hlth Command, Aberdeen Proving Ground, MD USA. [Smith, Darci R.] Colorado State Univ, Coll Vet Med & Biomed Sci, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA. [O'Guinn, Monica L.] US Army, Med Res Inst Infect Dis, Mil Infect Dis Res Program, Ft Detrick, MD 21702 USA. [Lee, John S.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD USA. RP Turell, MJ (reprint author), US Army, Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA. EM lawrence.n.petz.mil@mail.mil; michael.j.turell@us.army.mil; susana.padillal@us.army.mil; lewis.s.long@us.army.mil; Drew.reinbold@us.army.mil; darci.smith@colostate.edu; monica.oguinn@us.army.mil; vanessa.melanson@us.army.mil; john.s.lee13@gmail.com FU Military Infectious Disease Research Program [U0176_09_RD] FX This work was funded, in part, by Military Infectious Disease Research Program Project U0176_09_RD. NR 22 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 2014 VL 91 IS 4 BP 666 EP 671 DI 10.4269/ajtmh.13-0218 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA AQ6XQ UT WOS:000342957600004 PM 25114013 ER PT J AU Hajjar, RM AF Hajjar, Remi M. TI Military Warriors as Peacekeeper-Diplomats: Building Productive Relationships with Foreign Counterparts in the Contemporary Military Advising Mission SO ARMED FORCES & SOCIETY LA English DT Article DE military advising mission; postmodern military culture; cultural toolkit; peacekeeper-diplomat cultural tools; warrior cultural tools; cross-cultural competence AB This project examines the sophisticated cultural toolkit deployed by contemporary US military advisors to successfully build productive relationships with foreign security forces, advance the advising mission, and survive combat. This project's data stems from a three-part multi-method, including a survey conducted in Iraq; a document analysis; and interviews. This article focuses on numerous subthemes that coalesce to vividly divulge an intriguing story about how contemporary advisors build relationships with counterparts, including avoiding an Ugly American approach, how cross-cultural competence benefits the mission and increases survivability, learning about counterparts, the power of informal socializing, employing humor, navigating taboo topics, cultural stretching and associated limits, diplomatically balancing strength and subtlety, and taking physical and cultural risks. This project argues that effective advisors deploy a multifaceted cultural toolkit filled with peacekeeper-diplomat, warrior, subject matter expert, innovator, leader, and other tools, which reveals broader organizational changes indicative of emergent postmodern US military culture. C1 US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. RP Hajjar, RM (reprint author), US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. EM remi.hajjar@us.army.mil NR 35 TC 1 Z9 1 U1 0 U2 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0095-327X EI 1556-0848 J9 ARMED FORCES SOC JI Armed Forces Soc. PD OCT PY 2014 VL 40 IS 4 BP 647 EP 672 DI 10.1177/0095327X13493275 PG 26 WC Political Science; Sociology SC Government & Law; Sociology GA AQ4TM UT WOS:000342792600003 ER PT J AU Carr, ML Vuyovich, CM AF Carr, Meredith L. Vuyovich, Carrie M. TI Investigating the effects of long-term hydro-climatic trends on Midwest ice jam events SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article DE Hydro-climatic trends; Ice jam; River ice; Midwest; Freezeup; Flooding ID WATER-QUALITY; UNITED-STATES; RIVER; BREAKUP; STREAMFLOW; ECOLOGY; CANADA; COVER AB Ice freezeup, breakup and jamming events on northern rivers can cause extensive flooding, damage infrastructure, impede navigation, and impact stream stability and the environment. Under a changing climate the ice regime will change as well, meaning increased risk and uncertainty for affected areas. The layman's perception is that climate change is causing warming that is reducing the length of the ice season, so there will be less ice and less damaging impacts from river ice. The concept of 'less ice' is supported by studies showing shorter ice-affected seasons. However several studies have found that in temperate regions, the effects of climate trends increasing temperatures and precipitation - may actually exacerbate problems. In recent years, communities in the Midwest U.S. have experienced long duration ice jam events that have resulted in flooding, damages and evacuations. This study presents a first step in identifying trends in damaging ice events in the Midwest. We analyzed the ice regime of three rivers in the region to determine if trends in the hydro-climatic data support the increasing number of damaging freezeup jams observed in recent years, but no regional pattern in trends related to breakup jams were found. We found statistically increasing trends in discharge and precipitation, with no corresponding increase in winter period temperature, which provide evidence for the change in the ice regime for this region. A hindcasting analysis was used to construct a more complete record of historical ice events. This analysis revealed a statistically significant increase in frequency of freezeup jams for most sites and no regional trend in the frequency of midwinter or spring breakup jams. Some increase in the freezeup jam strength was indicated by an increasing trend in the number of freezing degree days (FDD) in the freezeup jam formation period. Communities need to shift their emergency preparedness for river ice problems from the existing focus on relatively regular, short-acting spring breakups. Future emergency management plans need to prepare to respond to the risk and impact of freezeup jams that, according to this analysis, are increasing in frequency and strength while occurring with less predictability and having longer term effects if they freeze in place. Published by Elsevier B.V. C1 [Carr, Meredith L.; Vuyovich, Carrie M.] US Army, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. RP Carr, ML (reprint author), US Army, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03755 USA. EM meredith.l.carr@usace.army.mil; carrie.m.vuyovich@usace.army.mil FU Institute for Water Resources of the U.S. Army Corps of Engineers; U.S. Army Engineer Research and Development Center's Cold Regions Research and Engineering Laboratory FX This work was supported by the Institute for Water Resources of the U.S. Army Corps of Engineers and the U.S. Army Engineer Research and Development Center's Cold Regions Research and Engineering Laboratory. We are grateful to Andrew Tuthill, Dr. Kathleen White and Callan George for their thorough review and comments, to Bill Morris from NOAA for his great photos, to John Gagnon for help with data retrieval, and to Don Arvin, Kevin Housel, Robert Howell, Tom Weaver and John Latour from the IN, WI, MI and IL offices of the U.S. Geological Survey for their assistance in obtaining archived data. NR 69 TC 0 Z9 0 U1 0 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X EI 1872-7441 J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD OCT-NOV PY 2014 VL 106 BP 66 EP 81 DI 10.1016/j.coldregions.2014.06.003 PG 16 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA AQ5WN UT WOS:000342879400009 ER PT J AU Poh, PYS Carter, R Hinojosa-Laborde, C Mulligan, J Grudic, GZ Convertino, VA AF Poh, Paula Y. S. Carter, Robert, III Hinojosa-Laborde, Carmen Mulligan, Jane Grudic, Gregory Z. Convertino, Victor A. TI Respiratory pump contributes to increased physiological reserve for compensation during simulated haemorrhage SO EXPERIMENTAL PHYSIOLOGY LA English DT Article ID CEREBRAL-BLOOD-FLOW; INSPIRATORY RESISTANCE; CENTRAL HYPOVOLEMIA; CARDIAC-ARREST; SHOCK; HYPOTENSION; SYMPTOMS; HUMANS; VOLUME AB Intrathoracic pressure regulation (IPR) represents a therapy for increasing systemic circulation through the creation of negative intrathoracic pressure. We hypothesized that using this 'respiratory pump' effect would slow the diminution of the physiological reserve to compensate during progressive reductions in central blood volume. The compensatory reserve index (CRI) algorithm was used to measure the proportion (from 100 to 0%) of reserve capacity that remained to compensate for central volume loss before the onset of cardiovascular decompensation. Continuous analog recordings of arterial waveforms were extracted from data files of seven healthy volunteers. Subjects had previously participated in experiments designed to induce haemodynamic decompensation (presyncope) by progressive reduction in central blood volume using graded lower-body negative pressure. The lower-body negative pressure protocol was completed while breathing spontaneously through a standard medical face mask without (placebo) and with a resistance (approximately -7 cmH(2)O; active IPR) applied during inspiration. At the onset of presyncope in the placebo conditions, CRI was smaller than the CRI observed at the same time point in the active IPR conditions. The CRI at the onset of presyncope during active IPR (0.08 +/- 0.01) was similar to the CRI at presyncope with placebo. Kaplan-Meier and log rank tests indicated that CRI survival curves were shifted to the right by active IPR. Optimizing the respiratory pump contributed a small but significant effect of increasing tolerance to progressive reductions in central blood volume by extending the compensatory reserve. C1 [Poh, Paula Y. S.; Carter, Robert, III; Hinojosa-Laborde, Carmen; Convertino, Victor A.] US Army, Inst Surg Res, JBSA, Ft Sam Houston, TX 78234 USA. [Mulligan, Jane; Grudic, Gregory Z.] Flashback Technol Inc, Boulder, CO 80301 USA. RP Convertino, VA (reprint author), US Army, Inst Surg Res, JBSA, Ft Sam Houston, TX 78234 USA. EM victor.a.convertino.civ@mail.mil FU United States Army Medical Research; Materiel Command Combat Casualty Research Program FX Funding support was provided by the United States Army Medical Research and Materiel Command Combat Casualty Research Program. NR 20 TC 6 Z9 6 U1 0 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0958-0670 EI 1469-445X J9 EXP PHYSIOL JI Exp. Physiol. PD OCT 1 PY 2014 VL 99 IS 10 BP 1421 EP 1426 DI 10.1113/expphysiol.2014.081208 PG 6 WC Physiology SC Physiology GA AQ5BS UT WOS:000342818300018 PM 25016024 ER PT J AU Streeck, H AF Streeck, H. TI Immunopathogenesis of HIV-Disease SO JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT LA German DT Meeting Abstract C1 [Streeck, H.] Henry M Jackson Fdn, Walter Reed Army Inst Res, US Mil HIV Res Program, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1610-0379 EI 1610-0387 J9 J DTSCH DERMATOL GES JI J. Dtsch. Dermatol. Ges. PD OCT PY 2014 VL 12 IS 10 MA V23 BP 951 EP 951 PG 1 WC Dermatology SC Dermatology GA AQ4GC UT WOS:000342750400047 ER PT J AU Schoenfeld, AJ Mok, JM Cameron, B Jackson, KL Serrano, JA Freedman, BA AF Schoenfeld, Andrew J. Mok, James M. Cameron, Brian Jackson, Keith L. Serrano, Jose A. Freedman, Brett A. TI Evaluation of Immediate Postoperative Complications and Outcomes Among Military Personnel Treated for Spinal Trauma in Afghanistan A Cohort-Control Study of 50 Cases SO JOURNAL OF SPINAL DISORDERS & TECHNIQUES LA English DT Article DE spinal trauma; combat; surgery; outcomes ID IMPROVISED EXPLOSIVE DEVICE; COMBAT CASUALTY CARE; INJURIES; IRAQ AB Study Design: Retrospective case-control study. Objective: The objective of the study was to compare neurological outcomes and complication rates between a series of combat-injured patients treated in Afghanistan (AFG) and those treated at Landstuhl Regional Medical Center (LRMC). Summary of Background Data: At present, no studies have addressed the ideal timing and setting for surgical stabilization in combat-injured soldiers who sustain spinal trauma. Methods: Soldiers who sustained spine injuries while deployed to Afghanistan and who underwent surgery in theater or at LRMC between 2010 and 2011 were identified. Demographic information, injury-specific data, neurological status, type of surgical intervention, postoperative complications, and need for additional surgery were abstracted for all patients. Neurological improvement was the primary dependent variable. Secondary variables included the risk of developing complications and the need for additional surgery. Statistical analysis was performed using t tests, and the Fisher exact test was used for categorical variables. Results: Between 2010 and 2011, 30 individuals were treated in AFG, and 20 received surgery at LRMC. Neurological improvement occurred in 10% of AFG patients and 5% of those treated at LRMC. Complications occurred in 40% of AFG patients and in 20% of the LRMC group. Twenty-three percent of AFG patients required additional spine surgery after leaving Afghanistan. There was no statistical difference in neurological improvement between the AFG and LRMC groups (P = 0.64). Soldiers who received surgery in AFG were at significantly increased risk of requiring additional procedures (P = 0.03). Conclusions: Soldiers treated in theater did not have statistically higher rates of neurological improvement as compared with those treated at LRMC. Patients treated in-theater were at elevated risk for the need for additional surgery. This study is among the first to evaluate clinical outcomes after surgical intervention for war-related spinal trauma. C1 [Schoenfeld, Andrew J.; Serrano, Jose A.] Texas Tech Univ, Hlth Sci Ctr, Dept Orthopaed Surg, William Beaumont Army Med Ctr, El Paso, TX USA. [Mok, James M.] Madigan Army Med Ctr, Orthopaed Surg Serv, Tacoma, WA 98431 USA. [Cameron, Brian] Virginia Commonwealth Univ, Med Ctr, Dept Neurosurg, Harold F Young Neurosurg Ctr, Richmond, VA USA. [Jackson, Keith L.] Dwight D Eisenhower Army Med Ctr, Dept Orthopaed Surg, Ft Gordon, GA USA. [Freedman, Brett A.] Landstuhl Reg Med Ctr, Spine & Neurosurg Serv, D-66849 Landstuhl, Germany. RP Freedman, BA (reprint author), Landstuhl Reg Med Ctr, Spine & Neurosurg Serv, Bldg 3703, D-66849 Landstuhl, Germany. EM brettfreedman@yahoo.com OI Schoenfeld, Andrew/0000-0002-3691-1215 NR 19 TC 2 Z9 2 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1536-0652 EI 1539-2465 J9 J SPINAL DISORD TECH JI J. Spinal Disord. Tech. PD OCT PY 2014 VL 27 IS 7 BP 376 EP 381 PG 6 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA AQ8AV UT WOS:000343043900011 PM 24999556 ER PT J AU Brown, TN Palmieri-Smith, RM Mclean, SG AF Brown, Tyler N. Palmieri-Smith, Riann M. Mclean, Scott G. TI COMPARATIVE ADAPTATIONS OF LOWER LIMB BIOMECHANICS DURING UNILATERAL AND BILATERAL LANDINGS AFTER DIFFERENT NEUROMUSCULAR-BASED ACL INJURY PREVENTION PROTOCOLS SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Article DE injury prevention; knee; plyometric; core stability ID CRUCIATE LIGAMENT INJURIES; LOWER-EXTREMITY BIOMECHANICS; FEMALE TEAM HANDBALL; JOINT COORDINATE SYSTEM; TRAINING-PROGRAM; VIDEO ANALYSIS; KNEE-JOINT; KINEMATICS; RISK; MECHANISMS AB Brown, TN, Palmieri-Smith, RM, and McLean, SG. Comparative adaptations of lower limb biomechanics during unilateral and bilateral landings after different neuromuscular-based ACL injury prevention protocols. J Strength Cond Res 28(10): 2859-2871, 2014Potentially valuable anterior cruciate ligament (ACL) injury prevention strategies are lengthy, limiting training success. Shorter protocols that achieve beneficial biomechanical adaptations may improve training effectiveness. This study examined whether core stability/balance and plyometric training can modify female landing biomechanics compared with the standard neuromuscular and no training models. Forty-three females had lower limb biomechanics analyzed during unilateral and bilateral landings immediately before and after a 6-week neuromuscular or no training programs. Sagittal and frontal plane hip and knee kinematics and kinetics were submitted to 3-way repeated-measures analyses of variance to test for the main and interaction effects of training group, landing type, and testing time. Greater peak knee flexion was evident in the standard neuromuscular group following training, during both bilateral (p = 0.027) and unilateral landings (p = 0.076 and d = 0.633). The plyometric group demonstrated reduced hip adduction (p = 0.010) and greater knee flexion (p = 0.065 and d = 0.564) during bilateral landings following training. The control group had significant reduction in peak stance knee abduction moment (p = 0.003) posttraining as compared with pretraining. The current outcomes suggest that significant biomechanical changes are possible by an isolated plyometric training component. The benefits, however, may not be evident across all landing types, seemingly limited to simplistic, bilateral landings. Integrated training protocols may still be the most effective training model, currently improving knee flexion posture during both bilateral and unilateral landings following training. Future prevention efforts should implement integrated training protocols that include plyometric exercises to reduce ACL injury risk of female athletes. C1 [Brown, Tyler N.] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. [Palmieri-Smith, Riann M.; Mclean, Scott G.] Univ Michigan, Sch Kinesiol, Ann Arbor, MI 48109 USA. RP Brown, TN (reprint author), US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. EM tyler.n.brown4.civ@mail.mil NR 37 TC 3 Z9 3 U1 4 U2 32 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1064-8011 EI 1533-4287 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD OCT PY 2014 VL 28 IS 10 BP 2859 EP 2871 DI 10.1519/JSC.0000000000000472 PG 13 WC Sport Sciences SC Sport Sciences GA AQ6CG UT WOS:000342894800021 PM 24714537 ER PT J AU Olivola, CY Eubanks, DL Lovelace, JB AF Olivola, Christopher Y. Eubanks, Dawn L. Lovelace, Jeffrey B. TI The many (distinctive) faces of leadership: Inferring leadership domain from facial appearance SO LEADERSHIP QUARTERLY LA English DT Article DE Leadership perception; Judgment accuracy; Nonverbal behavior; Social perception; Implicit leadership theories ID CHIEF EXECUTIVE OFFICERS; CATEGORIZATION THEORY; ILLUSORY CORRELATION; PHYSICAL APPEARANCE; 1ST IMPRESSIONS; MILITARY RANK; PERFORMANCE; JUDGMENTS; DOMINANCE; SUCCESS AB Previous research has shown that people form impressions of potential leaders from their faces and that certain facial features predict success in reaching prestigious leadership positions. However, much less is known about the accuracy or meta-accuracy of face-based leadership inferences. Here we examine a simple, but important, question: Can leadership domain be inferred from faces? We find that human judges can identify business, military, and sports leaders (but not political leaders) from their faces with above-chance accuracy. However, people are surprisingly bad at evaluating their own performance on this judgment task: We find no relationship between how well judges think they performed and their actual accuracy levels. In a follow-up study, we identify several basic dimensions of evaluation that correlate with face-based judgments of leadership domain, as well as those that predict actual leadership domain. We discuss the implications of our results for leadership perception and selection. (C) 2014 Elsevier Inc. All rights reserved. C1 [Olivola, Christopher Y.] Carnegie Mellon Univ, Tepper Sch Business, Pittsburgh, PA 15213 USA. [Eubanks, Dawn L.] Univ Warwick, Warwick Business Sch, Behav Sci Grp, Coventry CV4 7AL, Warwick, England. [Lovelace, Jeffrey B.] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. RP Olivola, CY (reprint author), Carnegie Mellon Univ, Tepper Sch Business, Posner Hall 255-B,5000 Forbes Ave, Pittsburgh, PA 15213 USA. EM olivola@cmu.edu; dawn.eubanks@wbs.ac.uk; jeffrey.lovelace@usma.edu RI Olivola, Christopher/A-5630-2010 OI Olivola, Christopher/0000-0002-3359-3055 NR 63 TC 11 Z9 11 U1 5 U2 20 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1048-9843 EI 1873-3409 J9 LEADERSHIP QUART JI Leadersh. Q. PD OCT PY 2014 VL 25 IS 5 BP 817 EP 834 DI 10.1016/j.leaqua.2014.06.002 PG 18 WC Psychology, Applied; Management SC Psychology; Business & Economics GA AQ5SO UT WOS:000342869100003 ER PT J AU Fry, LW Hannah, ST Noel, M Walumbwa, FO AF Fry, Louis W. Hannah, Sean T. Noel, Michael Walumbwa, Fred O. TI Impact of spiritual leadership on unit performance (Retraction of vol 22, pg 259, 2011) SO LEADERSHIP QUARTERLY LA English DT Correction ID TESTS; FIT C1 [Fry, Louis W.] Texas A&M Cent Texas, Killeen, TX 76549 USA. [Hannah, Sean T.] US Mil Acad, Ctr Army Profess & Eth, West Point, NY 10996 USA. [Noel, Michael] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. [Walumbwa, Fred O.] Arizona State Univ, WP Carey Sch Business, Dept Management, Tempe, AZ 85287 USA. RP Fry, LW (reprint author), Texas A&M Cent Texas, 1901 South Clear Creek Rd, Killeen, TX 76549 USA. NR 8 TC 0 Z9 0 U1 2 U2 24 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1048-9843 EI 1873-3409 J9 LEADERSHIP QUART JI Leadersh. Q. PD OCT PY 2014 VL 25 IS 5 BP 1073 EP 1074 DI 10.1016/j.leaqua.2014.07.005 PG 2 WC Psychology, Applied; Management SC Psychology; Business & Economics GA AQ5SO UT WOS:000342869100023 ER PT J AU Fry, LW Hannah, ST Noel, M Walumbwa, FO AF Fry, Louis W. Hannah, Sean T. Noel, Michael Walumbwa, Fred O. TI Impact of spiritual leadership on unit performance (Retraction of vol 23, pg 641, 2012) SO LEADERSHIP QUARTERLY LA English DT Correction C1 [Fry, Louis W.] Texas A&M Cent Texas, Killeen, TX 76549 USA. [Hannah, Sean T.] US Mil Acad, Ctr Army Profess & Eth, West Point, NY 10996 USA. [Noel, Michael] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. [Walumbwa, Fred O.] Arizona State Univ, WP Carey Sch Business, Dept Management, Tempe, AZ 85287 USA. RP Fry, LW (reprint author), Texas A&M Cent Texas, 1901 South Clear Creek Rd, Killeen, TX 76549 USA. NR 1 TC 0 Z9 0 U1 2 U2 12 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1048-9843 EI 1873-3409 J9 LEADERSHIP QUART JI Leadersh. Q. PD OCT PY 2014 VL 25 IS 5 BP 1075 EP 1075 DI 10.1016/j.leaqua.2014.07.007 PG 1 WC Psychology, Applied; Management SC Psychology; Business & Economics GA AQ5SO UT WOS:000342869100024 ER PT J AU Stanley, DA Honko, AN Asiedu, C Trefry, JC Lau-Kilby, AW Johnson, JC Hensley, L Ammendola, V Abbate, A Grazioli, F Foulds, KE Cheng, C Wang, LS Donaldson, MM Colloca, S Folgori, A Roederer, M Nabel, GJ Mascola, J Nicosia, A Cortese, R Koup, RA Sullivan, NJ AF Stanley, Daphne A. Honko, Anna N. Asiedu, Clement Trefry, John C. Lau-Kilby, Annie W. Johnson, Joshua C. Hensley, Lisa Ammendola, Virginia Abbate, Adele Grazioli, Fabiana Foulds, Kathryn E. Cheng, Cheng Wang, Lingshu Donaldson, Mitzi M. Colloca, Stefano Folgori, Antonella Roederer, Mario Nabel, Gary J. Mascola, John Nicosia, Alfredo Cortese, Riccardo Koup, Richard A. Sullivan, Nancy J. TI Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge SO NATURE MEDICINE LA English DT Article ID NONHUMAN-PRIMATES; VIRUS INFECTION; VECTOR; IMMUNOGENICITY; QUALITY AB Ebolavirus disease causes high mortality, and the current outbreak has spread unabated through West Africa. Human adenovirus type 5 vectors (rAd5) encoding ebolavirus glycoprotein (GP) generate protective immunity against acute lethal Zaire ebolavirus (EBOV) challenge in macaques, but fail to protect animals immune to Ad5, suggesting natural Ad5 exposure may limit vaccine efficacy in humans. Here we show that a chimpanzee-derived replication-defective adenovirus (ChAd) vaccine also rapidly induced uniform protection against acute lethal EBOV challenge in macaques. Because protection waned over several months, we boosted ChAd3 With modified vaccinia Ankara (MVA) and generated, for the first time, durable protection against lethal EBOV Challenge. C1 [Stanley, Daphne A.; Asiedu, Clement; Lau-Kilby, Annie W.; Foulds, Kathryn E.; Cheng, Cheng; Wang, Lingshu; Donaldson, Mitzi M.; Roederer, Mario; Nabel, Gary J.; Mascola, John; Koup, Richard A.; Sullivan, Nancy J.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. [Honko, Anna N.; Trefry, John C.; Johnson, Joshua C.; Hensley, Lisa] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. [Ammendola, Virginia; Abbate, Adele; Grazioli, Fabiana; Colloca, Stefano; Folgori, Antonella; Nicosia, Alfredo] Okairos, Rome, Italy. [Nicosia, Alfredo] Ctr Ingn Genet CEINGE, Naples, Italy. [Nicosia, Alfredo] Univ Naples Federico II, Dept Mol Med & Med Biotechnol, Naples, Italy. [Cortese, Riccardo] Keires AG, Basel, Switzerland. RP Sullivan, NJ (reprint author), NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. EM njsull@mail.nih.gov OI Lau-Kilby, Annie/0000-0002-2666-1347; Johnson, Joshua/0000-0002-5677-3841; Honko, Anna/0000-0001-9165-148X FU US NIH NIAID Vaccine Research Center FX We thank M. Cichanowski for graphics, A. Tislerics and B. Hartman for assistance with the manuscript and R. Seder for review and helpful suggestions. S. Perfetto and S. Norris and D. Follmann for technical discussions, and the Vaccine Research Center's Nonhuman Primate Immunogenicity Core for NHP sample processing. We thank the Vaccine Research Center Laboratory Animal Medicine, S. Rao, A. Taylor, J.P. Todd and H. Bao for protocol support and the NIH Division of Veterinary Resources for animal care. We also thank H. Esham for technical assistance and data management and D. Alves for pathology assistance. TPG shuttle vector was provided by A. Siccardi (Istituto San Raffaele). This work was supported by the Intramural Research Program of the US NIH NIAID Vaccine Research Center. Opinions, interpretations, conclusions and recommendations are those of the authors and are not necessarily endorsed by the US Army or the US Department of Defense. NR 22 TC 97 Z9 99 U1 2 U2 43 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1078-8956 EI 1546-170X J9 NAT MED JI Nat. Med. PD OCT PY 2014 VL 20 IS 10 BP 1126 EP 1129 DI 10.1038/nm.3702 PG 4 WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental Medicine GA AQ9RV UT WOS:000343194100022 PM 25194571 ER PT J AU Stankorb, SM Ramsey, C Clark, H Osgood, T AF Stankorb, Susan M. Ramsey, Casside Clark, Heidi Osgood, Tamara TI Provision of Nutrition Support Therapies in the Recent Iraq and Afghanistan Conflicts SO NUTRITION IN CLINICAL PRACTICE LA English DT Review DE nutrition assessment; wounds and injuries; trauma centers; nutritional support; medical ethics; trauma ID CARE AIR TRANSPORT; EN-ROUTE CARE; MILITARY; TRAUMA AB This article describes the experience of nutrition support practitioners, specifically dietitians, providing care to combat casualties. It provides a brief overview of dietitians' induction into armed service but focuses primarily on their role in providing nutrition support during the most recent conflicts in Iraq and Afghanistan. The current system of combat casualty care is discussed with specific emphasis on providing early and adequate nutrition support to U. S. combat casualties from injury, care in theater combat support hospitals (CSHs)/expeditionary medical support (EMEDs), and en route care during critical care air transport (CCAT) up to arrival at treatment facilities in the United States. The article also examines practices and challenges faced in the CSHs/EMEDs providing nutrition support to non-U.S. or coalition patients. Over the past decade in armed conflicts, dietitians, physicians, nurses, and other medical professionals have risen to challenges, have implemented systems, and continue working to optimize treatment across the spectrum of combat casualty care. C1 [Stankorb, Susan M.] Brooke Army Med Ctr, San Antonio, TX 78217 USA. [Stankorb, Susan M.; Clark, Heidi] US Mil Baylor Grad Program Nutr, San Antonio, TX USA. [Stankorb, Susan M.; Ramsey, Casside; Osgood, Tamara] US Army, Washington, DC USA. [Ramsey, Casside] Landstuhl Reg Med Ctr, Landstuhl, Germany. [Clark, Heidi] US Air Force, Washington, DC USA. [Osgood, Tamara] Evans Army Community Hosp, Ft Carson, CO USA. RP Stankorb, SM (reprint author), Brooke Army Med Ctr, 4254 Hilton Head St, San Antonio, TX 78217 USA. EM susan.stankorb.mil@mail.mil NR 34 TC 0 Z9 0 U1 0 U2 3 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0884-5336 EI 1941-2452 J9 NUTR CLIN PRACT JI Nutr. Clin. Pract. PD OCT PY 2014 VL 29 IS 5 BP 605 EP 611 DI 10.1177/0884533614543329 PG 7 WC Nutrition & Dietetics SC Nutrition & Dietetics GA AQ5ME UT WOS:000342852500005 PM 25606636 ER PT J AU Bland, CM Bookstaver, DA Hatzigeorgiou, C Sweeney, LB AF Bland, Christopher M. Bookstaver, David A. Hatzigeorgiou, Christos Sweeney, Lori B. TI Warfarin dose requirements after sleeve gastrectomy surgery. SO PHARMACOTHERAPY LA English DT Meeting Abstract CT Annual Meeting of the American-College-of-Clinical-Pharmacy (ACCP) CY OCT 12-15, 2014 CL Austin, TX SP Amer Coll Clin Pharm C1 [Bland, Christopher M.] Eisenhower Army Med Ctr, Dept Clin Pharm, Ft Gordon, GA USA. [Bookstaver, David A.] Eisenhower Army Med Ctr, Ft Gordon, GA USA. [Hatzigeorgiou, Christos] Eisenhower Army Med Ctr, Dept Internal Med, Ft Gordon, GA USA. [Sweeney, Lori B.] Virginia Commonwealth Univ, Div Endocrinol & Metab, Dept Internal Med, Richmond, VA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0277-0008 EI 1875-9114 J9 PHARMACOTHERAPY JI Pharmacotherapy PD OCT PY 2014 VL 34 IS 10 MA 254 BP E243 EP E244 PG 2 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA AQ6JF UT WOS:000342916800202 ER PT J AU Bland, CM Hatzigeorgiou, C Bookstaver, DA Sweeney, LB Haseth, M AF Bland, Christopher M. Hatzigeorgiou, Christos Bookstaver, David A. Sweeney, Lori B. Haseth, Margueritede TI Clinical effect of sitagliptin on hemoglobin A1c after sleeve gastrectomy. SO PHARMACOTHERAPY LA English DT Meeting Abstract CT Annual Meeting of the American-College-of-Clinical-Pharmacy (ACCP) CY OCT 12-15, 2014 CL Austin, TX SP Amer Coll Clin Pharm C1 [Bland, Christopher M.] Eisenhower Army Med Ctr, Dept Clin Pharm, Ft Gordon, GA USA. [Hatzigeorgiou, Christos] Eisenhower Army Med Ctr, Dept Internal Med, Ft Gordon, GA USA. [Bookstaver, David A.] Eisenhower Army Med Ctr, Ft Gordon, GA USA. [Sweeney, Lori B.] Virginia Commonwealth Univ, Dept Internal Med, Div Endocrinol & Metab, Richmond, VA USA. [Haseth, Margueritede] Med Univ S Carolina, Charleston, SC 29425 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0277-0008 EI 1875-9114 J9 PHARMACOTHERAPY JI Pharmacotherapy PD OCT PY 2014 VL 34 IS 10 MA 247 BP E242 EP E242 PG 1 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA AQ6JF UT WOS:000342916800196 ER PT J AU Bookstaver, D Bland, C AF Bookstaver, David Bland, Christopher TI Correlation of cefpodoxime susceptibility with cefazolin and cefuroxime among urinary tract isolates. SO PHARMACOTHERAPY LA English DT Meeting Abstract CT Annual Meeting of the American-College-of-Clinical-Pharmacy (ACCP) CY OCT 12-15, 2014 CL Austin, TX SP Amer Coll Clin Pharm C1 [Bookstaver, David; Bland, Christopher] Eisenhower Army Med Ctr, Dept Pharm, Ft Gordon, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0277-0008 EI 1875-9114 J9 PHARMACOTHERAPY JI Pharmacotherapy PD OCT PY 2014 VL 34 IS 10 MA 118 BP E208 EP E208 PG 1 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA AQ6JF UT WOS:000342916800089 ER PT J AU Tenan, MS Brothers, RM Tweedell, AJ Hackney, AC Griffin, L AF Tenan, Matthew S. Brothers, R. Matthew Tweedell, Andrew J. Hackney, Anthony C. Griffin, Lisa TI Changes in resting heart rate variability across the menstrual cycle SO PSYCHOPHYSIOLOGY LA English DT Article DE Heart rate variability; Autonomic nervous system; Menstrual cycle; Estrogen; Progesterone ID BASAL BODY-TEMPERATURE; YOUNG-WOMEN; ENERGY-EXPENDITURE; METABOLIC-RATE; POWER SPECTRA; HEALTHY; TONE; ACETYLCHOLINE; PROGESTERONE; BAROREFLEXES AB Heart rate variability (HRV) is a noninvasive indicator of autonomic control. This study examines HRV changes across a normal menstrual cycle and proposes a novel piecewise function controlling for the effects of breathing on HRV spectral parameters. A resting ECG was collected from 13 women at five points in their menstrual cycle. Both heart rate and breathing rate increased across the cycle (p<.01) while time-domain variability decreased (p=.04). Use of the piecewise function for breathing rate in HRV spectral analysis was confirmed by a substantial increase in model goodness-of-fit. HRV spectral parameters, controlled for breathing with the piecewise function, confirm that the decrease in variability is likely due to a parasympathetic withdrawal, since high frequency HRV decreases (p=.02). C1 [Tenan, Matthew S.; Brothers, R. Matthew; Tweedell, Andrew J.; Griffin, Lisa] Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA. [Tenan, Matthew S.] US Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA. [Tweedell, Andrew J.; Hackney, Anthony C.] Univ N Carolina, Dept Exercise & Sport Sci, Appl Physiol Lab, Endocrine Sect, Chapel Hill, NC USA. RP Griffin, L (reprint author), Univ Texas Austin, Dept Kinesiol & Hlth Educ, Bellmont 222,1 Univ Stn,D3700, Austin, TX 78712 USA. EM l.griffin@austin.utexas.edu NR 52 TC 7 Z9 7 U1 2 U2 17 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0048-5772 EI 1469-8986 J9 PSYCHOPHYSIOLOGY JI Psychophysiology PD OCT PY 2014 VL 51 IS 10 BP 996 EP 1004 DI 10.1111/psyp.12250 PG 9 WC Psychology, Biological; Neurosciences; Physiology; Psychology; Psychology, Experimental SC Psychology; Neurosciences & Neurology; Physiology GA AQ5AF UT WOS:000342813400007 PM 24942292 ER PT J AU House, JM AF House, Jonathan M. TI Cold War: An International History SO RUSSIAN REVIEW LA English DT Book Review C1 [House, Jonathan M.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. RP House, JM (reprint author), US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0036-0341 EI 1467-9434 J9 RUSS REV JI Russ. Rev. PD OCT PY 2014 VL 73 IS 4 BP 650 EP 651 PG 2 WC History SC History GA AQ3GS UT WOS:000342679700040 ER PT J AU Gauer, R Larocque, J AF Gauer, Robert Larocque, Justin TI JNC 8: Relaxing the Standards SO AMERICAN FAMILY PHYSICIAN LA English DT Editorial Material ID ISOLATED SYSTOLIC HYPERTENSION; BLOOD-PRESSURE; OLDER; PREVENTION; GUIDELINES; MANAGEMENT C1 [Gauer, Robert; Larocque, Justin] Womack Army Med Ctr, Ft Bragg, NC 28307 USA. RP Gauer, R (reprint author), Womack Army Med Ctr, Ft Bragg, NC 28307 USA. EM robert.l.gauer2.civ@mail.mil NR 14 TC 0 Z9 0 U1 0 U2 2 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X EI 1532-0650 J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD OCT 1 PY 2014 VL 90 IS 7 BP 449 EP + PG 3 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA AQ3UL UT WOS:000342718900004 PM 25369620 ER PT J AU Seehusen, DA Baird, DC Bode, DV AF Seehusen, Dean A. Baird, Drew C. Bode, David V. TI Dyspareunia in Women SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID SEXUAL DYSFUNCTION; VULVAR VESTIBULITIS; VULVODYNIA; PREVALENCE; PAIN AB Dyspareunia is recurrent or persistent pain with sexual activity that causes marked distress or interpersonal conflict. It affects approximately 10% to 20% of U.S. women. Dyspareunia can have a significant impact on a woman's mental and physical health, body image, relationships with partners, and efforts to conceive. The patient history should be taken in a nonjudgmental way and progress from a general medical history to a focused sexual history. An educational pelvic examination allows the patient to participate by holding a mirror while the physician explains normal and abnormal findings. This examination can increase the patient's perception of control, improve self-image, and clarify findings and how they relate to discomfort. The history and physical examination are usually sufficient to make a specific diagnosis. Common diagnoses include provoked vulvodynia, inadequate lubrication, postpartum dyspareunia, and vaginal atrophy. Vaginismus may be identified as a contributing factor. Treatment is directed at the underlying cause of dyspareunia. Depending on the diagnosis, pelvic floor physical therapy, lubricants, or surgical intervention may be included in the treatment plan. (Copyright (C) 2014 American Academy of Family Physicians.) C1 [Seehusen, Dean A.] Eisenhower Army Med Ctr, Dept Family & Community Med, Ft Gordon, GA USA. [Baird, Drew C.] Carl R Darnall Army Med Ctr, Family Med Residency Program, Ft Hood, TX USA. [Bode, David V.] Eisenhower Army Med Ctr, Family Med Residency Program, Ft Gordon, GA USA. RP Seehusen, DA (reprint author), Dept Family & Community Med, Bldg 300, Ft Gordon, GA 30909 USA. EM dseehusen@msn.com NR 28 TC 1 Z9 1 U1 2 U2 12 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X EI 1532-0650 J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD OCT 1 PY 2014 VL 90 IS 7 BP 465 EP 470 PG 6 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA AQ3UL UT WOS:000342718900008 PM 25369624 ER PT J AU Yu, AB Abrams, RA Zacks, JM AF Yu, Alfred B. Abrams, Richard A. Zacks, Jeffrey M. TI Limits on Action Priming by Pictures of Objects SO JOURNAL OF EXPERIMENTAL PSYCHOLOGY-HUMAN PERCEPTION AND PERFORMANCE LA English DT Article DE action priming; affordance; stimulus-response compatibility ID VISUAL OBJECT; GESTURAL KNOWLEDGE; ACTION STATE; AFFORDANCE; POTENTIATION; REPRESENTATIONS; COMPONENTS; DISCRIMINATION; CATEGORIZATION; PERCEPTION AB When does looking at an object prime actions associated with using it, and what aspects of those actions are primed? We examined whether viewing manmade objects with handles would selectively facilitate responses for the hand closest to the handle, attempting to replicate a study reported by Tucker and Ellis (1998). We also examined whether the hypothesized action priming effects depended upon the response hand's proximity to an object. In 7 experiments, participants made judgments about whether pictured objects were manmade or natural or whether the objects were upright or inverted. They responded by pressing buttons located either on the same or opposite side as the objects' handles, at variable distances. Action priming was observed only when participants were explicitly instructed to imagine picking up the pictured objects while making their judgments; the data provide no evidence for task-general automatic priming of lateralized responses by object handles. These data indicate that visually encoding an object activates spatially localized action representations only under special circumstances. C1 [Yu, Alfred B.; Abrams, Richard A.; Zacks, Jeffrey M.] Washington Univ, Dept Psychol, St Louis, MO 63130 USA. [Yu, Alfred B.] US Army, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Yu, AB (reprint author), US Army, Res Lab, RDRL HRS C, Aberdeen Proving Ground, MD 21005 USA. EM alfred.b.yu.civ@mail.mil RI Zacks, Jeffrey/E-9099-2011 OI Zacks, Jeffrey/0000-0003-1171-3690 FU United States Department of Defense Science, Mathematics, and Research for Transformation (SMART); NIMH [RO1MH70674]; NIA [R01AG031150] FX This work was supported by a United States Department of Defense Science, Mathematics, and Research for Transformation (SMART) scholarship to the first author, and NIMH Grant RO1MH70674 and NIA Grant R01AG031150 to the third author. NR 42 TC 9 Z9 10 U1 2 U2 9 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0096-1523 EI 1939-1277 J9 J EXP PSYCHOL HUMAN JI J. Exp. Psychol.-Hum. Percept. Perform. PD OCT PY 2014 VL 40 IS 5 BP 1861 EP 1873 DI 10.1037/a0037397 PG 13 WC Psychology; Psychology, Experimental SC Psychology GA AQ0XV UT WOS:000342506900014 PM 25045901 ER PT J AU Knox, JB Schneider, JE Cage, JM Wimberly, RL Riccio, AI AF Knox, Jeffrey B. Schneider, John E. Cage, Jason M. Wimberly, Robert L. Riccio, Anthony I. TI Spine Trauma in Very Young Children: A Retrospective Study of 206 Patients Presenting to a Level 1 Pediatric Trauma Center SO JOURNAL OF PEDIATRIC ORTHOPAEDICS LA English DT Article DE spine; trauma; cervical; fracture; infant; pediatric ID CERVICAL-SPINE; INJURIES; FRACTURES; AGE; ADOLESCENTS; CLEARANCE; SEVERITY; CORD AB Background: The immature spine has anatomic and biomechanical properties that differ from the adult spine and result in unique characteristics of pediatric spinal trauma. Although distinct patterns of spinal injury have been identified in children younger than 10 years of age, little research has explored the differing characteristics of spinal trauma within this age group, particularly in the very young. The purpose of this study is to identify differences in the epidemiology and characteristics of spinal trauma between children under the age of 4 years and those between 4 and 9 years of age. Methods: A review of all patients treated for spinal injury at a single large level I pediatric trauma center between 2003 and 2011 was conducted. Demographic data, injury mechanism, neurologic status, and details of any associated injuries were compiled. Radiographic studies were used to determine injury location and fracture classification. The patient population was divided into 2 groups: the infantile/toddler (IT) group (ages 0 to 3 y) and the young (Y) group (ages 4 to 9 y). Data were compared between these groups using the chi(2) test and the Student t test to identify differences in injury characteristics. Results: A total of 206 patients were identified. Fifty-seven patients were between 0 and 3 years of age and 149 were between 4 and 9 years old. Although motor vehicle collision was the most common cause of injury in both the groups, nonaccidental trauma was responsible for 19% of spine trauma among patients aged 0 to 3 years. Cervical spine injuries were much more common in the youngest patients (P<0.05) with injuries primarily in the upper cervical spine. Children in the IT group were more likely to sustain ligamentous injuries, whereas Y patients had more compression fractures (P<0.05). Neurologic injury was common in both the groups with IT patients more often presenting with complete loss of function or hemiplegia and Y patients sustaining more spinal cord injuries (P<0.05). IT patients had a 25% mortality rate, which was significantly higher than that of the Y group (P=0.005). Conclusions: This study shows many significant differences in characteristics of spinal injury in infants/toddlers when compared with older children. These differences can help guide diagnostic evaluation and initial management, as well as future prevention efforts. Level of Evidence: Level III. C1 [Knox, Jeffrey B.; Cage, Jason M.] Tripler Army Med Ctr, Orthoped Surg Serv, Honolulu, HI 96859 USA. [Schneider, John E.] Univ Texas SW Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USA. [Schneider, John E.; Wimberly, Robert L.; Riccio, Anthony I.] Childrens Med Ctr, Dallas, TX 75235 USA. [Wimberly, Robert L.; Riccio, Anthony I.] Texas Scottish Rite Hosp Children, Dept Orthoped, Dallas, TX 75219 USA. RP Riccio, AI (reprint author), 1935 Med Dist Dr, Dallas, TX 75235 USA. EM Anthony.riccio@childrens.com NR 30 TC 6 Z9 6 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0271-6798 EI 1539-2570 J9 J PEDIATR ORTHOPED JI J. Pediatr. Orthop. PD OCT-NOV PY 2014 VL 34 IS 7 BP 698 EP 702 PG 5 WC Orthopedics; Pediatrics SC Orthopedics; Pediatrics GA AQ2KY UT WOS:000342616000010 PM 25207594 ER PT J AU Sawyer, T Leonard, D Sierocka-Castaneda, A Chan, D Thompson, M AF Sawyer, T. Leonard, D. Sierocka-Castaneda, A. Chan, D. Thompson, M. TI Correlations between technical skills and behavioral skills in simulated neonatal resuscitations SO JOURNAL OF PERINATOLOGY LA English DT Article ID NONTECHNICAL SKILLS; DELIBERATE PRACTICE; DELIVERY-ROOM; PEDIATRIC RESIDENTS; COGNITIVE LOAD; EFFECT SIZE; TEAMWORK; EDUCATION; PERFORMANCE; STATISTICS AB OBJECTIVE: Neonatal resuscitation requires both technical and behavioral skills. Key behavioral skills in neonatal resuscitation have been identified by the Neonatal Resuscitation Program. Correlations and interactions between technical skills and behavioral skills in neonatal resuscitation were investigated. STUDY DESIGN: Behavioral skills were evaluated via blinded video review of 45 simulated neonatal resuscitations using a validated assessment tool. These were statistically correlated with previously obtained technical skill performance data. RESULT: Technical skills and behavioral skills were strongly correlated (rho=0.48; P=0.001). The strongest correlations were seen in distribution of workload (rho= 0.60; P=0.01), utilization of information (rho= 0.55; P=0.03) and utilization of resources (rho= 0.61; P=0.01). Teams with superior behavioral skills also demonstrated superior technical skills, and vice versa. CONCLUSION: Technical and behavioral skills were highly correlated during simulated neonatal resuscitations. Individual behavioral skill correlations are likely dependent on both intrinsic and extrinsic factors. C1 [Sawyer, T.] Univ Washington, Sch Med, Dept Pediat, Seattle, WA 98195 USA. [Leonard, D.] Sacred Heart Med Ctr, Eugene, OR USA. [Sierocka-Castaneda, A.] Natl Naval Med Ctr, Dept Pediat, Bethesda, MD USA. [Chan, D.; Thompson, M.] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. RP Sawyer, T (reprint author), Univ Washington, Sch Med, Dept Pediat, Div Neonatol,HSB, 1959 NE Pacific St,RR 539, Seattle, WA 98195 USA. EM tlsawyer@uw.edu NR 34 TC 7 Z9 7 U1 0 U2 6 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0743-8346 EI 1476-5543 J9 J PERINATOL JI J. Perinatol. PD OCT PY 2014 VL 34 IS 10 BP 781 EP 786 DI 10.1038/jp.2014.93 PG 6 WC Obstetrics & Gynecology; Pediatrics SC Obstetrics & Gynecology; Pediatrics GA AQ3TT UT WOS:000342717100012 PM 24831522 ER PT J AU Reed, DS Glass, PJ Bakken, RR Barth, JF Lind, CM da Silva, L Hart, MK Rayner, J Alterson, K Custer, M Dudek, J Owens, G Kamrud, KI Parker, MD Smith, J AF Reed, Douglas S. Glass, Pamela J. Bakken, Russell R. Barth, James F. Lind, Cathleen M. da Silva, Luis Hart, Mary Kate Rayner, Jonathan Alterson, Kim Custer, Max Dudek, Jeanne Owens, Gary Kamrud, Kurt I. Parker, Michael D. Smith, Jonathan TI Combined Alphavirus Replicon Particle Vaccine Induces Durable and Cross-Protective Immune Responses against Equine Encephalitis Viruses SO JOURNAL OF VIROLOGY LA English DT Article ID SUBTYPE-I-D; NONHUMAN-PRIMATES; EASTERN EQUINE; CYNOMOLGUS MACAQUES; AEROSOL CHALLENGE; DNA VACCINE; ENCEPHALOMYELITIS VACCINES; NEUTRALIZING ANTIBODIES; ATTENUATED VACCINES; ANIMAL-MODELS AB Alphavirus replicons were evaluated as potential vaccine candidates for Venezuelan equine encephalitis virus (VEEV), western equine encephalitis virus (WEEV), or eastern equine encephalitis virus (EEEV) when given individually or in combination (V/W/E) to mice or cynomolgus macaques. Individual replicon vaccines or the combination V/W/E replicon vaccine elicited strong neutralizing antibodies in mice to their respective alphavirus. Protection from either subcutaneous or aerosol challenge with VEEV, WEEV, or EEEV was demonstrated out to 12 months after vaccination in mice. Individual replicon vaccines or the combination V/W/E replicon vaccine elicited strong neutralizing antibodies in macaques and demonstrated good protection against aerosol challenge with an epizootic VEEV-IAB virus, Trinidad donkey. Similarly, the EEEV replicon and V/W/E combination vaccine elicited neutralizing antibodies against EEEV and protected against aerosol exposure to a North American variety of EEEV. Both the WEEV replicon and combination V/W/E vaccination, however, elicited poor neutralizing antibodies to WEEV in macaques, and the protection conferred was not as strong. These results demonstrate that a combination V/W/E vaccine is possible for protection against aerosol challenge and that cross-interference between the vaccines is minimal. IMPORTANCE Three related viruses belonging to the genus Alphavirus cause severe encephalitis in humans: Venezuelan equine encephalitis virus (VEEV), western equine encephalitis virus (WEEV), and eastern equine encephalitis virus (EEEV). Normally transmitted by mosquitoes, these viruses can cause disease when inhaled, so there is concern that these viruses could be used as biological weapons. Prior reports have suggested that vaccines for these three viruses might interfere with one another. We have developed a combined vaccine for Venezuelan equine encephalitis, western equine encephalitis, and eastern equine encephalitis expressing the surface proteins of all three viruses. In this report we demonstrate in both mice and macaques that this combined vaccine is safe, generates a strong immune response, and protects against aerosol challenge with the viruses that cause Venezuelan equine encephalitis, western equine encephalitis, and eastern equine encephalitis. C1 [Reed, Douglas S.; da Silva, Luis] US Army, Med Res Inst Infect Dis, Ctr Aerobiol Sci, Ft Detrick, MD 21702 USA. [Glass, Pamela J.; Bakken, Russell R.; Barth, James F.; Lind, Cathleen M.; Hart, Mary Kate; Parker, Michael D.] US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Rayner, Jonathan; Alterson, Kim; Custer, Max; Dudek, Jeanne; Owens, Gary; Kamrud, Kurt I.; Smith, Jonathan] AlphaVax Inc, Res Triangle Pk, NC USA. RP Reed, DS (reprint author), Univ Pittsburgh, Ctr Vaccine Res, Pittsburgh, PA 15260 USA. EM dsreed@pitt.edu OI Reed, Douglas/0000-0003-0076-9023 FU National Institutes of Health [U01 AI056438-04]; Department of Defense [H.H.0003_07_RD_B] FX The National Institutes of Health (grant U01 AI056438-04) and Department of Defense (grant H.H.0003_07_RD_B) funded this work. NR 49 TC 3 Z9 3 U1 2 U2 9 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X EI 1098-5514 J9 J VIROL JI J. Virol. PD OCT PY 2014 VL 88 IS 20 BP 12077 EP 12086 DI 10.1128/JVI.01406-14 PG 10 WC Virology SC Virology GA AQ3JH UT WOS:000342688000040 PM 25122801 ER PT J AU De Rossi, SS Thoppay, J Dickinson, DP Looney, S Stuart, M Ogbureke, KUE Hsu, S AF De Rossi, Scott S. Thoppay, Jaisri Dickinson, Douglas P. Looney, Stephen Stuart, Mary Ogbureke, Kalu U. E. Hsu, Stephen TI A phase II clinical trial of a natural formulation containing tea catechins for xerostomia SO ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY LA English DT Article ID HUMAN SJOGRENS-SYNDROME; INDUCED DRY MOUTH; MURINE MODEL; DOUBLE-BLIND; GLAND-CELLS; MALIC-ACID; EFFICACY; LACTOPEROXIDASE; LACTOFERRIN; 1-PERCENT AB Objective. Previous animal studies indicated catechins from the tea plant (Camellia sinensis) may modulate salivary function and possess a therapeutic effect for xerostomia. The objective of this study was to evaluate a natural formulation containing tea catechins in 60 patients with xerostomia, including patients with Sjogren syndrome. Study Design. This study used a double-blind, placebo-controlled, randomized design. The functional placebo contained all natural formulation ingredients and 500 mg xylitol, but without the key plant extracts. Results. After 8 weeks of therapy, the xylitol-containing placebo failed to modulate saliva output. In comparison, the catechin-containing natural formulation resulted in a statistically significant increase in unstimulated (3.8-fold) and stimulated (2.1-fold) saliva output vs baseline. The quality of life score showed a significant improvement in both groups but no significant difference between groups. Conclusions. The catechin-containing natural formula partially restored salivary function in patients with xerostomia and provided an objective improvement in saliva output, which warrants large-scale clinical trials. C1 [De Rossi, Scott S.; Looney, Stephen; Hsu, Stephen] Georgia Regents Univ, Augusta, GA 30912 USA. [Thoppay, Jaisri] Univ Penn, Philadelphia, PA 19104 USA. [Dickinson, Douglas P.] US Army, Dent Activ DENTAC, Ft Gordon, GA USA. [Stuart, Mary] Tingay Dent Clin, Ft Gordon, GA USA. [Ogbureke, Kalu U. E.] Univ Texas Hlth Sci Ctr Houston, Sch Dent, Houston, TX 77030 USA. RP Hsu, S (reprint author), Georgia Regents Univ, CB2040,1120 15th St, Augusta, GA 30912 USA. EM shsu@gru.edu FU International Association for Dental Research/GlaxoSmithKline Innovation in Oral Care Award; Georgia Research Alliance FX This study was support in part by an International Association for Dental Research/GlaxoSmithKline Innovation in Oral Care Award (2011) and by a grant from the Georgia Research Alliance. NR 23 TC 2 Z9 2 U1 0 U2 9 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 2212-4403 EI 1528-395X J9 OR SURG OR MED OR PA JI Oral Surg. Oral Med. Oral Pathol. Oral Radiol. PD OCT PY 2014 VL 118 IS 4 BP 447 EP U186 DI 10.1016/j.oooo.2014.06.015 PG 11 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA AQ0VW UT WOS:000342501800016 PM 25240992 ER PT J AU O'Connor, V Arena, E Albright, J Brown, N O'Connor, R Chung, M Dinome, M Shamonki, J AF O'Connor, Victoria Arena, Elizabeth Albright, Joslyn Brown, Nefertiti O'Connor, Ryan Chung, Maureen Dinome, Maggie Shamonki, Jaime TI Histological Assessment of Breast Lesions Identified Exclusively by Magnetic Resonance SO AMERICAN SURGEON LA English DT Article ID MRI; BIOPSY; CANCER; MAMMOGRAPHY; SOCIETY; WOMEN AB Radiologic-pathologic correlation of lesions diagnosed by magnetic resonance (MR) is precluded by insufficient data on histological characteristics of lesions suspicious on MR but not visible on concurrent mammogram or ultrasound. The objective of this study was to describe histological features of breast lesions diagnosed exclusively by MR. The participants underwent MR-guided breast biopsy between 2007 and 2012 for a suspicious lesion not identified by mammography or ultrasound. Histology slides were interpreted retrospectively by a breast pathologist. Of 126 patients (126 lesions), 34 (27%) had new breast cancer, 51 (40.5%) previous breast cancer, and 41 (32.5%) dense breasts or a significant family history of breast cancer. MR identified 23 (18.3%) invasive cancers: 20 were Grade 1 and 17 were ductal. Of the 126 lesions, 16 (13%) were ductal carcinoma in situ (DCIS), four were atypical ductal hyperplasia and atypical lobular hyperplasia (3%), and 68 (54%) were benign. Fifteen biopsies (12%) had no significant pathology. Five DCIS lesions were upgraded to T1 invasive cancers. Approximately 30 per cent of suspicious lesions detected exclusively by MR are invasive or in situ cancers that are predominantly low grade. Further studies are needed to determine if malignant lesions can be prospectively distinguished by MR characteristics. C1 [Chung, Maureen; Dinome, Maggie] St Johns Hlth Ctr, Margie & Robert Petersen Breast Canc Res Program, Santa Monica, CA USA. [O'Connor, Victoria; Arena, Elizabeth; Albright, Joslyn; Brown, Nefertiti; Chung, Maureen; Dinome, Maggie] St Johns Hlth Ctr, John Wayne Canc Inst, Santa Monica, CA USA. [O'Connor, Victoria; Arena, Elizabeth; Albright, Joslyn; Brown, Nefertiti; Chung, Maureen; Dinome, Maggie; Shamonki, Jaime] St Johns Hlth Ctr, Dept Pathol, Santa Monica, CA USA. [O'Connor, Ryan] United States Army Reserve, Los Angeles, CA USA. RP Shamonki, J (reprint author), 2121 Santa Monica Blvd, Santa Monica, CA 90404 USA. EM Jaime.Shamonki@stjohns.org NR 16 TC 0 Z9 0 U1 0 U2 1 PU SOUTHEASTERN SURGICAL CONGRESS PI CUMMING PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA SN 0003-1348 EI 1555-9823 J9 AM SURGEON JI Am. Surg. PD OCT PY 2014 VL 80 IS 10 BP 944 EP 947 PG 4 WC Surgery SC Surgery GA AP7SV UT WOS:000342277900007 PM 25264635 ER PT J AU Freedman, BA Serrano, JA Belmont, PJ Jackson, KL Cameron, B Neal, CJ Wells, R Yeoman, C Schoenfeld, AJ AF Freedman, Brett A. Serrano, Jose A. Belmont, Philip J., Jr. Jackson, Keith L. Cameron, Brian Neal, Chris J. Wells, Rosemary Yeoman, Chevas Schoenfeld, Andrew J. TI The combat burst fracture study-results of a cohort analysis of the most prevalent combat specific mechanism of major thoracolumbar spinal injury SO ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY LA English DT Article DE Burst fracture; Thoracolumbar region; Combat; Incidence ID CLASSIFICATION; AFGHANISTAN; TRAUMA; IRAQ AB In 2009-2010, military physicians hypothesized that a new pattern of spinal injury had emerged, resulting from improvised explosive device assault on up-armored vehicles, associated with a high rate of point of first contact fracture and neurological injury-the combat burst fracture. We sought to determine the incidence of all thoracolumbar (TL) burst fractures and combat burst fractures in 2009-2010 as compared to two antecedent years. A screening process identified all individuals who sustained TL burst fractures in the time-period studied. Demographics, injury-specific characteristics, mechanism of injury, surgical interventions and early complications were recorded. Incidence rates were calculated for the three time periods using total deployed troop-strength and number of LRMC combat admissions as denominators. The incidences of TL burst fractures within each year group and by mechanism were compared, and clinical characteristics and process of care were described. Between 2007-2010, 65 individuals sustained a TL burst fracture. The incidence of these injuries in 2009-2010 was 2.1 per 10,000 soldier-years and accounted for 3.0 % of LRMC combat-casualty admissions, a significant increase from 0.6 % and 1.1 % in 2007-2008 and 2008-2009, respectively (p a parts per thousand currency sign 0.001). In 2009-2010, US soldiers were 3.4-4.6 times more likely to sustain a TL burst fracture compared to 2008-2009 and 2007-2008 (p < 0.001), and the most common mechanism of injury was IED vs. vehicle (65 %)-the combat burst fracture mechanism. Neurological deficits were present in 43 % of TL burst fractures and 1/3 were complete injuries. Spinal fixation was performed in 68 % overall and 74 % of combat burst fractures. There was a 3.4- to 4.6-fold increase in TL burst fractures in 2009-2010 compared to antecedent years. The primary driver of this phenomenon was the marked increased in combat burst fractures. Mitigating/preventing the mechanism behind this major spinal injury is a key research initiative for the US military. Level of Evidence III (Case-control). C1 [Freedman, Brett A.; Neal, Chris J.; Yeoman, Chevas] Landstuhl Reg Med Ctr, Spine & Neurosurg Serv, Landstuhl, Germany. [Serrano, Jose A.; Belmont, Philip J., Jr.] Texas Tech Univ, Hlth Sci Ctr, Dept Orthopaed Surg, William Beaumont Army Med Ctr, El Paso, TX USA. [Jackson, Keith L.] Dwight D Eisenhower Army Med Ctr, Dept Orthopaed Surg, Ft Gordon, GA USA. [Cameron, Brian] Virginia Commonwealth Univ, Harold Young Neurosurg Ctr, Med Ctr, Dept Neurosurg, Richmond, VA USA. [Wells, Rosemary] Brooke Army Med Ctr, Ctr Intrepid, San Antonio, TX USA. [Schoenfeld, Andrew J.] Univ Michigan, Dept Orthopaed Surg, Ann Arbor Vet Adm Hosp, Ann Arbor, MI 48109 USA. RP Schoenfeld, AJ (reprint author), Univ Michigan, Dept Orthopaed Surg, Ann Arbor Vet Adm Hosp, 2800 Plymouth Rd,Bldg 10,RM G016, Ann Arbor, MI 48109 USA. EM brettfreedman@yahoo.com; aschoenf@umich.edu OI Belmont, Philip/0000-0003-2618-199X; Schoenfeld, Andrew/0000-0002-3691-1215 NR 18 TC 5 Z9 6 U1 2 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0936-8051 EI 1434-3916 J9 ARCH ORTHOP TRAUM SU JI Arch. Orthop. Trauma Surg. PD OCT PY 2014 VL 134 IS 10 BP 1353 EP 1359 DI 10.1007/s00402-014-2066-9 PG 7 WC Orthopedics; Surgery SC Orthopedics; Surgery GA AP9TR UT WOS:000342423400002 PM 25107602 ER PT J AU Melanson, VR Scheirer, JL Kalina, WV Wagar, EJ AF Melanson, Vanessa R. Scheirer, Jessica L. Kalina, Warren V. Wagar, Eric J. TI Real-time Leishmania genus master mix: a platform compatibility and stability study SO DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE LA English DT Article DE Leishmania; Real-time PCR; Master mix; Platform comparison; Stability ID POLYMERASE-CHAIN-REACTION; PCR ASSAY; DIAGNOSIS AB Performing diagnostics and vector-pathogen surveillance in austere environments is challenging. On-site diagnostic/detection mitigates vector-borne disease complications during military or humanitarian deployments to disease endemic locals. The mobile molecular diagnostic platform, Joint Biological Agent Identification and Diagnostic System (JBAIDS; BioFire Diagnostics Inc., Salt Lake City, UT, USA), rapidly identifies biothreat pathogens. Although ideal for remote diagnostics, the platform was validated for specific pathogens of insignificant epidemiological consequence. Recognizing the JBAIDS's remote diagnostic/detection versatility, we tested a Leishmania genus real-time PCR master mix validated for use on the SmartCycler (R) (Cepheid, Sunnyvale, CA, USA) for concomitant use on the JBAIDS. We evaluated assay sensitivity, precision, and specificity of one or more Leishmania spp. on the JBAIDS and found that the JBAIDS produces superior detection sensitivity and specificity compared to the SmartCycler. We also examined the storage stability of a bulk lot preparation of the Leishmania genus real-time PCR master mix on the SmartCycler to ensure that long periods of frozen storage that would translate to a field environment with the JBAIDS were not detrimental to the reagent. We found that the bulk master mix maintains its stability over a 13-month time period. Overall, these studies confirm JBAIDS's versatility and demonstrate a streamlined assay development approach where reagents are compatible with both platforms. (C) 2014 Published by Elsevier Inc. C1 [Melanson, Vanessa R.; Scheirer, Jessica L.] Walter Reed Army Inst Res, Diagnost & Lab Serv Dept, Entomol Branch, Silver Spring, MD 20910 USA. [Kalina, Warren V.] US Army Res Inst Infect Dis, Syst Dev Dept, Diagnost Syst Div, Ft Detrick, MD 21702 USA. [Wagar, Eric J.] Walter Reed Army Inst Res, Wound Infect Dept, Bacterial Dis Branch, Silver Spring, MD 20910 USA. RP Melanson, VR (reprint author), Walter Reed Army Inst Res, Diagnost & Lab Serv Dept, Entomol Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM vanessa.melanson@us.army.mil; jessica.l.scheirer.ctr@mail.mil; warren.kalina@us.army.mil; eric.j.wagar2.mil@mail.mil FU Endemic Disease branch, 1st Area Medical Laboratory, United States Army FX We would like to thank SPC Shanna Moyd Holmes Atere and SPC Megan E. Clark both formally of the Medical Laboratory Specialist, 1st Area Medical Laboratory, Building 5116, Bel Air St, Aberdeen Proving Ground, MD 21005, for their technical assistance. We would like to thank Karen M. Bingham-Ferlez for assistance provided in peer review. The material presented in this article has been reviewed by the Walter Reed Army Institute of Research. There is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private views of the author(s) and are not to be constructed as official or as reflecting true views of the Department of the Army or the Department of Defense. This study was funded by the Endemic Disease branch, 1st Area Medical Laboratory, United States Army. NR 19 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0732-8893 EI 1879-0070 J9 DIAGN MICR INFEC DIS JI Diagn. Microbiol. Infect. Dis. PD OCT PY 2014 VL 80 IS 2 BP 97 EP 101 DI 10.1016/j.diagmicrobio.2014.07.002 PG 5 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA AP8KZ UT WOS:000342329200002 PM 25112901 ER PT J AU Tan, J Baron, D Dai, LY AF Tan, Jin Baron, Dror Dai, Liyi TI Wiener Filters in Gaussian Mixture Signal Estimation With l(infinity)-Norm Error SO IEEE TRANSACTIONS ON INFORMATION THEORY LA English DT Article DE Estimation theory; Gaussian mixtures; l(infinity)-norm error; linear mixing systems; parallel Gaussian channels; Wiener filters ID INFINITY NORM; SPREAD CDMA; MAXIMUM AB Consider the estimation of a signal x is an element of R-N from noisy observations r = x + z, where the input x is generated by an independent and identically distributed (i. i. d.) Gaussian mixture source, and z is additive white Gaussian noise in parallel Gaussian channels. Typically, the l(2)-norm error (squared error) is used to quantify the performance of the estimation process. In contrast, we consider the l(infinity)-norm error (worst case error). For this error metric, we prove that, in an asymptotic setting where the signal dimension N ->infinity, the l(infinity)-norm error always comes from the Gaussian component that has the largest variance, and the Wiener filter asymptotically achieves the optimal expected l(infinity)-norm error. The i. i. d. Gaussian mixture case can be extended to i. i. d. Bernoulli-Gaussian distributions, which are often used to model sparse signals. Finally, our results can be extended to linear mixing systems with i. i. d. Gaussian mixture inputs, in settings where a linear mixing system can be decoupled to parallel Gaussian channels. C1 [Tan, Jin; Baron, Dror] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. [Dai, Liyi] US Army Res Off, Div Comp Sci, Durham, NC 27709 USA. RP Tan, J (reprint author), N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. EM jtan@ncsu.edu; barondror@ncsu.edu; liyi.dai.civ@mail.mil FU National Science Foundation [CCF-1217749]; U.S. Army Research Office [W911NF-04-D-0003] FX This work was supported in part by the National Science Foundation under Grant CCF-1217749 and in part by the U.S. Army Research Office under Grant W911NF-04-D-0003. This paper was presented at the 2013 Information Theory and Applications Workshop [1] and 2014 IEEE Conference on Information Sciences and Systems [2]. NR 35 TC 3 Z9 3 U1 1 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9448 EI 1557-9654 J9 IEEE T INFORM THEORY JI IEEE Trans. Inf. Theory PD OCT PY 2014 VL 60 IS 10 BP 6626 EP 6635 DI 10.1109/TIT.2014.2345260 PG 10 WC Computer Science, Information Systems; Engineering, Electrical & Electronic SC Computer Science; Engineering GA AP9RH UT WOS:000342416900047 ER PT J AU Hui, FK Schuette, AJ Spiotta, AM Yim, J Obuchowski, N Rasmussen, PA Hussain, MS Cawley, CM Dion, JE Tong, FC AF Hui, Ferdinand K. Schuette, A. Jesse Spiotta, Alejandro M. Yim, John Obuchowski, Nancy Rasmussen, Peter A. Hussain, Mohammed Shazam Cawley, C. Michael Dion, Jacques E. Tong, Frank C. TI Flexible tip guides and intermediate catheters: two center experience and a proposed taxonomy SO JOURNAL OF NEUROINTERVENTIONAL SURGERY LA English DT Review ID MECHANICAL EMBOLUS REMOVAL; ACUTE ISCHEMIC-STROKE; INTRACRANIAL ANEURYSMS; CEREBRAL-ISCHEMIA; DISTAL ACCESS; MERCI TRIAL; THROMBECTOMY; SYSTEM; SAFETY; HELPS AB Background Stable access to target lesions is foundational to endovascular therapy, be it in hemorrhagic or ischemic disease. Continued evolution in access technology has resulted in next generation catheters that afford improved trackability and proximal support. Objective Assess safety and patterns of use at two high volume centers, and conceptualize usage patterns. Materials and methods A retrospective review of 608 cases in which a 'next generation' catheter was used during 2008-2010 at Cleveland Clinic (Cleveland, Ohio, USA) and throughout 2009-2010 at Emory University Hospital (Atlanta, Georgia, USA) was conducted, and the cases classified by indication. Catheter placement, distal most location, and related complications were recorded and experience summarized. We also reviewed the differences in the catheters and the rationale for catheter selection, as well as relative costs for each approach. Results 311 Neuron 053, 166 Neuron 070, 36 distal access catheter (DAC) 3.9 F, 61 DAC 4.3 F, and 34 DAC 5.2 F catheters were deployed. Of these, 459 placements were in the anterior circulation, 130 in the posterior circulation, 11 in the external carotid artery, and eight were used intravenously. Complication rates were 9/131(6.9%) for the DAC catheter group, 16/311 (5.1%) for the Neuron 053 group, and 14/166 (8.4%) for the Neuron 070 group (p=0.37, chi(2) test). Conclusions Next generation access catheters possess characteristics that blend qualities of traditional microcatheters and stiff guide catheters. There was no statistically significant difference in complication rates between the various catheter families in this small retrospective review, and the complication rates were similar to historical complication rates. C1 [Hui, Ferdinand K.; Rasmussen, Peter A.; Hussain, Mohammed Shazam] Cleveland Clin, Cerebrovasc Ctr Neurol Inst, Cleveland, OH 44195 USA. [Schuette, A. Jesse] Tripler Army Med Ctr, Dept Neurosurg, Honolulu, HI 96859 USA. [Spiotta, Alejandro M.] Med Univ S Carolina, Dept Neurosci, Div Neurosurg, Charleston, SC 29425 USA. [Yim, John] NASA, Glenn Res Ctr, Mech & Fluid Syst Div, Cleveland, OH USA. [Obuchowski, Nancy] Cleveland Clin, Quantitat Hlth Serv, Cleveland, OH 44106 USA. [Cawley, C. Michael; Dion, Jacques E.; Tong, Frank C.] Emory Univ, Dept Radiol, Atlanta, GA 30322 USA. [Cawley, C. Michael; Dion, Jacques E.; Tong, Frank C.] Emory Univ, Dept Neurosurg, Atlanta, GA 30322 USA. RP Hui, FK (reprint author), Cleveland Clin, Cerebrovasc Ctr Neurol Inst, 9500 Euclid Ave,S-80, Cleveland, OH 44195 USA. EM huif@ccf.org NR 20 TC 1 Z9 2 U1 0 U2 2 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1759-8478 EI 1759-8486 J9 J NEUROINTERV SURG JI J. NeuroInterventional Surg. PD OCT PY 2014 VL 6 IS 8 BP 618 EP 623 DI 10.1136/neurintsurg-2013-010892 PG 6 WC Neuroimaging; Surgery SC Neurosciences & Neurology; Surgery GA AQ1FX UT WOS:000342528400010 PM 24014468 ER PT J AU Nindl, BC Pierce, JR Rarick, KR Tuckow, AP Alemany, JA Sharp, MA Kellogg, MD Patton, JF AF Nindl, Bradley C. Pierce, Joseph R. Rarick, Kevin R. Tuckow, Alexander P. Alemany, Joseph A. Sharp, Marilyn A. Kellogg, Mark D. Patton, John F. TI Twenty-Hour Growth Hormone Secretory Profiles after Aerobic and Resistance Exercise SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE DECONVOLUTION ANALYSIS; EXERCISE RECOVERY; ENERGY EXPENDITURE; PITUITARY GLAND; LIPOLYSIS ID FACTOR-I; HYPOPHYSECTOMIZED RATS; TRAINING INTENSITY; REPEATED BOUTS; GH; MEN; ADULTS; METABOLISM; RESPONSES; LIPOLYSIS AB Introduction: The pulsatile secretion pattern of growth hormone (GH) is an important parameter of GH action at peripheral tissues, and more information is needed on how exercise impacts GH secretion. This study hypothesized that both aerobic and resistance exercise would exhibit dose-response relationships with respect to exercise duration and 20-h postexercise GH secretion. Methods: Eight healthy men randomly completed five separate conditions: 1) control (no exercise; CON), 2) a moderate-duration (1-h) aerobic exercise session (MA), 3) a long-duration (2-h) aerobic exercise session (LA), 4) a moderate-duration (1-h) resistance exercise session (MR), and 5) a long-duration (2-h) resistance exercise session (LR). Exercise intensity, diet, sleep, and physical activity were strictly controlled during each condition, and blood was sampled postexercise every 20 min for 20 h, and GH secretion parameters were analyzed via cluster and deconvolution analyses. Results: Only the 2-h aerobic exercise bout resulted in a significant amplification of GH secretion as evidenced by increases in GH burst peak amplitude (similar to 100%), basal GH secretion rate (similar to 127%), total GH basal secretion (similar to 120%), total pulsatile secretion (similar to 88%), and total GH secretion (similar to 89%) over the control (i.e., no exercise) condition. GH secretions for the resistance exercise conditions were not different from control. Conclusions: The fact that the 2-h aerobic exercise condition resulted in higher energy expenditure than the other exercise conditions could offer a partial explanation for the greater GH amplification because of the metabolic effects that GH exerts in stimulating postexercise lipolysis. We conclude that extending the duration of aerobic exercise, but not resistance exercise, from 1- to 2-h significantly amplifies GH secretion during a 20-h period. C1 [Nindl, Bradley C.; Pierce, Joseph R.; Rarick, Kevin R.; Tuckow, Alexander P.; Alemany, Joseph A.; Sharp, Marilyn A.; Patton, John F.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA. [Kellogg, Mark D.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. RP Nindl, BC (reprint author), US Army Res Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA. EM Bradley.nindl@us.army.mil NR 37 TC 0 Z9 0 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD OCT PY 2014 VL 46 IS 10 BP 1917 EP 1927 DI 10.1249/MSS.0000000000000315 PG 11 WC Sport Sciences SC Sport Sciences GA AP7BS UT WOS:000342233200006 PM 24576855 ER PT J AU Rowland, MR Ragina, NP Sarkar, J Uyehara, CFT Senagore, AJ AF Rowland, Michael R. Ragina, Neli P. Sarkar, Joy Uyehara, Catherine F. T. Senagore, Anthony J. TI Is arginine/asyrnetric dimethylarginine ratio depletion an indicator of insufficient resuscitation in a porcine model of hemorrhage-reperfusion? SO SURGERY LA English DT Article; Proceedings Paper CT 71st Annual Meeting of the Central-Surgical-Association / 65th Annual Cancer Symposium CY MAR 06-09, 2014 CL Indianapolis, IN SP Cent Surg Assoc ID CITRULLINE; SEPSIS; INJURY; SHOCK; INTERLEUKIN-6; METABOLISM; CYTOKINES; TRAUMA AB Background. Hemorrhagic shock leads to a complex cascade of metabolic and hormonal processes that may result in hypoperfusion, end organ damage, and death even when blood pressure is restored. Studies have shown that morbidity and mortality could be attributable to a diminished availability of endothelial-derived nitric oxide (eNO). It is unclear whether adequate levels of citrulline (CIT) and arginine (ARG)-the precursors of eNO synthesis are available to sustain the eNO needed to maintain adequate perfusion in severe shock. An indirect measure of eNO is the ratio between the levels of ARG and its inhibitor asymmetric dimethylarginine (ARG/ADMA). The purpose of the study was to identify the temporal impact of the ARG/ADMA ratio, ARG, CIT, and ADMA in response to hemorrhage and crystalloid fluid resuscitation by the use of a porcine model of severe hemorrhagic shock. Methods. Hemorrhagic shock was induced in Yorkshire cross pigs by mimicking a bleeding pattern of rapid uncontrolled hemorrhage to achieve a shed volume of 30 mL/kg, a 50% decrease in mean arterial pressure, and an oxygen debt of >60 mL/kg. Normal saline, up to 2 times the shed blood volume, was started I hour after the start of hemorrhage with the goal of restoring mean arterial pressure to >50 mm Hg. Hemodynamics, blood gas measurements, and plasma samples were obtained at baseline, 1 hour after the start of hemorrhage, and I hour after resuscitation. Amino acids were measured by liquid chromatography coupled to mass spectrometry. Results. During hemorrhage, a distinct subset of pigs was better able to tolerate ischemia than the rest. These pigs required less resuscitation, had evidence of better organ perfusion, and exhibited less of an increase in interleukin-6 (IL-6) after resuscitation. Compared with their less-tolerant counterparts, this group had a greater increase in CIT above baseline (analysis of variance, P < .05) with hemorrhage. ARG levels were similar and remained stable with hemorrhage, which indicated the similar availability of substrate for eNO synthesis but differences in the quantity produced in response to the blood volume loss. With crystalloid fluid resuscitation, ARG levels and ARG/ADMA. decreased (analysis of variance, P < .05), whereas CIT remained increased in the group less able to tolerate hemorrhage. ARG/ADMA decreased proportional to greater oxygen debt during hemorrhage and greater IL-6 levels with fluid resuscitation. Conclusion. Our results suggest that a sufficient decrease in MAP during hemorrhagic shock is associated with a subsequent increase in IL-6, persisting impairment of end organ perfusion, and evidence of ongoing eNO deficit and an increase in ADMA despite resuscitation. The ARG/ADMA ratio reflects both of these parameters and corresponds to the increase in IL-6 and persistent ischemia after resuscitation. We propose that the mechanism of IL-6 increase in trauma derives from eNO deficiency, and the ARG/ADMA ratio more accurately depicts the pathologic mechanism responsible for increased morbidity and mortality in trauma. C1 [Rowland, Michael R.; Sarkar, Joy; Uyehara, Catherine F. T.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Ragina, Neli P.; Senagore, Anthony J.] Cent Michigan Univ, Coll Med, Mt Pleasant, MI 48859 USA. RP Rowland, MR (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM michael.r.rowland.mil@mail.mil NR 23 TC 1 Z9 1 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0039-6060 J9 SURGERY JI Surgery PD OCT PY 2014 VL 156 IS 4 BP 861 EP 870 DI 10.1016/j.surg.2014.06.019 PG 10 WC Surgery SC Surgery GA AP9JV UT WOS:000342397000014 PM 25239335 ER PT J AU Ghimire, K Dulin, MW Atchison, RL Goodin, DG Hutchinson, JMS AF Ghimire, Kabita Dulin, Mike W. Atchison, Robert L. Goodin, Douglas G. Hutchinson, J. M. Shawn TI Identification of windbreaks in Kansas using object-based image analysis, GIS techniques and field survey SO AGROFORESTRY SYSTEMS LA English DT Article DE Shelterbelts; Soil conservation; Crop protection; Kansas; Great plains ID CLASSIFICATION; ACCURACY; COVER AB Windbreaks are valuable resources in conserving soils and providing crop protection in Great Plains states in the US. Currently, Kansas has no up-to date inventory of windbreaks. The goal of this project was to assist foresters with future windbreak renovation planning and reporting, by outlining a series of semi-automated digital image processing methods that rapidly identify windbreak locations. There were two specific objectives of this research. First, to develop semi-automated methods to identify the location of windbreaks in Kansas, this can be applied to other regions in Kansas and the Great Plains. We used a remote sensing technique known as object-based image analysis (OBIA) to classify windbreaks visible in the color aerial imagery of National Agriculture Imagery Program. We also combined GIS techniques and field survey to complement OBIA in generating windbreak inventory. The techniques successfully located more than 4500, windbreaks covering an approximate area of 2500, hectares in 14 Kansas counties. The second purpose of this research is to determine how well the results of the automated classification schemes match with other available windbreak data and the selected sample collected in the field. The overall accuracy of OBIA method was 58.97 %. OBIA combined with 'heads up' digitizing and field survey method yielded better result in identifying and locating windbreaks in the studied counties with overall accuracy of 96 %. C1 [Ghimire, Kabita; Goodin, Douglas G.; Hutchinson, J. M. Shawn] Kansas State Univ, Dept Geog, Manhattan, KS 66506 USA. [Dulin, Mike W.] US Army Corps Engineers, Kansas City, MO 64106 USA. [Atchison, Robert L.] Kansas State Univ, Kansas Forest Serv, Manhattan, KS 66506 USA. RP Ghimire, K (reprint author), Kansas State Univ, Dept Geog, Manhattan, KS 66506 USA. EM kabita@ksu.edu OI Hutchinson, J.M. Shawn/0000-0002-7667-8446 FU Kansas Forest Service through the USDA State and Private Forestry Western Competitive Resource Allocation grant program FX Funding for this project was provided by the Kansas Forest Service through the USDA State and Private Forestry Western Competitive Resource Allocation grant program. NR 43 TC 2 Z9 2 U1 1 U2 18 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0167-4366 EI 1572-9680 J9 AGROFOREST SYST JI Agrofor. Syst. PD OCT PY 2014 VL 88 IS 5 BP 865 EP 875 DI 10.1007/s10457-014-9731-4 PG 11 WC Agronomy; Forestry SC Agriculture; Forestry GA AP1VA UT WOS:000341858600010 ER PT J AU Rogers, DJ Collins, C Carroll, R Yager, P Cummings, B Raol, N Setlur, J Maturo, S Tremblay, S Quinones, E Noviski, N Hartnick, CJ AF Rogers, Derek J. Collins, Corey Carroll, Ryan Yager, Phoebe Cummings, Brian Raol, Nikhila Setlur, Jennifer Maturo, Stephen Tremblay, Sarah Quinones, Ernesto Noviski, Natan Hartnick, Christopher J. TI Operation Airway: The First Sustainable, Multidisciplinary, Pediatric Airway Surgical Mission SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE Operation Airway; pediatric; surgical; mission ID TRACHEOSTOMY; EXPERIENCE AB Objective: This study aimed to describe the development and implementation of the first sustainable, multidisciplinary, pediatric airway surgical mission in an underserved country. Methods: This prospective, qualitative study was conducted for the first 4 Operation Airway missions in Quito, Ecuador. The major goals of the missions were to assist children with aerodigestive abnormalities, create a sustainable program where the local team could independently provide for their own patient population, develop an educational curriculum and training program for the local team, and cultivate a collaborative approach to provide successful multidisciplinary care. Results: Twenty patients ages 4 months to 21 years were included. Twenty-three bronchoscopies, 5 salivary procedures, 2 tracheostomies, 1 T-tube placement, 1 tracheocutaneous fistula closure, 2 open granuloma excisions, and 6 laryngotracheal reconstructions (LTRs) were performed. All LTR patients were decannulated. A new type of LTR (1.5 stage) was developed to meet special mission circumstances. Two videofluoroscopic swallow studies and 40 bedside swallow evaluations were performed. One local pediatric otolaryngologist, I pediatric surgeon, 3 anesthesiologists, 7 intensivists, 16 nurses, and 2 speech-language pathologists have received training. More than 25 hours of lectures were given, and a website was created collaboratively for educational and informational dissemination (http://www.masseyeandear.org/specialties/pediatrics/pediatric-ent/airway/OperationAirway/). Conclusion: We demonstrated the successful creation of the first mission stemming from a teaching institution with the goal of developing a sustainable, autonomous surgical airway program. C1 [Rogers, Derek J.; Collins, Corey; Carroll, Ryan; Yager, Phoebe; Cummings, Brian; Raol, Nikhila; Tremblay, Sarah; Noviski, Natan; Hartnick, Christopher J.] Massachusetts Eye & Ear Infirm, Boston, MA 02114 USA. [Setlur, Jennifer] Yale New Haven Med Ctr, New Haven, CT 06504 USA. [Maturo, Stephen] Brooke Army Med Ctr, San Antonio, TX USA. [Quinones, Ernesto] Metropolitan Hosp, Quito, Ecuador. RP Hartnick, CJ (reprint author), Massachusetts Eye & Ear Infirm, 243 Charles St, Boston, MA 02114 USA. EM Christopher_Hartnick@meei.harvard.edu NR 10 TC 4 Z9 4 U1 2 U2 5 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-4894 EI 1943-572X J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD OCT PY 2014 VL 123 IS 10 BP 726 EP 733 DI 10.1177/0003489414534012 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA AP7MQ UT WOS:000342261800008 PM 24835243 ER PT J AU Unterborn, CT Kabbes, JE Pigott, JS Reaman, DM Panero, WR AF Unterborn, Cayman T. Kabbes, Jason E. Pigott, Jeffrey S. Reaman, Daniel M. Panero, Wendy R. TI THE ROLE OF CARBON IN EXTRASOLAR PLANETARY GEODYNAMICS AND HABITABILITY SO ASTROPHYSICAL JOURNAL LA English DT Article DE planets and satellites: composition; planets and satellites: interiors; planets and satellites: physical evolution; planets and satellites: tectonics; planets and satellites: terrestrial planets; stars: carbon ID EQUATION-OF-STATE; TO-OXYGEN RATIO; TERRESTRIAL PLANETS; THERMAL EVOLUTION; HIGH-PRESSURE; SUPER-EARTHS; PARAMETERIZED CONVECTION; THERMODYNAMIC PROPERTIES; COMPOSITIONAL DIVERSITY; MGSIO3 PEROVSKITE AB The proportions of oxygen, carbon, and major rock-forming elements (e.g., Mg, Fe, Si) determine a planet's dominant mineralogy. Variation in a planet's mineralogy subsequently affects planetary mantle dynamics as well as any deep water or carbon cycle. Through thermodynamic models and high pressure diamond anvil cell experiments, we demonstrate that the oxidation potential of C is above that of Fe at all pressures and temperatures, indicative of 0.1-2 Earth-mass planets. This means that for a planet with (Mg+2Si+Fe+2C)/O > 1, excess C in the mantle will be in the form of diamond. We find that an increase in C, and thus diamond, concentration slows convection relative to a silicate-dominated planet, due to diamond's similar to 3 order of magnitude increase in both viscosity and thermal conductivity. We assert then that in the C-(Mg+2Si+Fe)-O system, there is a compositional range in which a planet can be habitable. Planets outside of this range will be dynamically sluggish or stagnant, thus having limited carbon or water cycles leading to surface conditions inhospitable to life as we know it. C1 [Unterborn, Cayman T.; Kabbes, Jason E.; Pigott, Jeffrey S.; Panero, Wendy R.] Ohio State Univ, Sch Earth Sci, Columbus, OH 43202 USA. [Reaman, Daniel M.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Unterborn, CT (reprint author), Ohio State Univ, Sch Earth Sci, 125 South Oval Mall, Columbus, OH 43202 USA. EM unterborn.1@buckeyemail.osu.edu RI Panero, Wendy/C-9602-2009 FU NSF CAREER grant [EAR-60023026, PRF 47664-G8]; COMPRES FX This work is supported by NSF CAREER grant EAR-60023026 and PRF 47664-G8. X-ray and infrared experiments were performed at beamlines X17-C and U2A at the National Synchrotron Light Source at Brookhaven National Lab and supported by COMPRES. E.D.X. and T.E.M. analyses were performed at the Campus Electron Optics Facility at Ohio State University and Raman spectroscopy was performed at the Analytical Spectroscopy Laboratory in the Department of Chemistry at Ohio State University. The authors thank Jingzhu Hu for her help with the X-ray diffraction studies. NR 71 TC 6 Z9 6 U1 3 U2 17 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0004-637X EI 1538-4357 J9 ASTROPHYS J JI Astrophys. J. PD OCT 1 PY 2014 VL 793 IS 2 AR 124 DI 10.1088/0004-637X/793/2/124 PG 10 WC Astronomy & Astrophysics SC Astronomy & Astrophysics GA AP3HD UT WOS:000341965300055 ER PT J AU Warner, CM Barker, N Lee, SW Perkins, EJ AF Warner, Christopher M. Barker, Natalie Lee, Seung-Wuk Perkins, Edward J. TI M13 bacteriophage production for large-scale applications SO BIOPROCESS AND BIOSYSTEMS ENGINEERING LA English DT Article DE Biotechnology; Bacteriophage; Scale down; Fermentation ID FILAMENTOUS BACTERIOPHAGE; FERMENTATION; BIOREACTOR AB Bacteriophage materials have the potential to revolutionize medicine, energy production and storage, agriculture, solar cells, optics and many other fields. To fulfill these needs, this study examined critical process parameters during phage propagation to increase phage production capability. A representative scale-down system was created in tube spin reactors to allow parallel experimentation with single- and multi-variable analysis. Temperature, harvest time, media composition, feed regime, bacteriophage, and bacteria concentration were analyzed in the scale-down system. Temperature, media composition, and feeding regimens were found to affect phage production more than other factors. Temperature affected bacterial growth and phage production inversely. Multi-variate analysis identified an optimal parameter space which provided a significant improvement over the base line method. This method should be useful in scaled production of bacteriophage for biotechnology. C1 [Warner, Christopher M.; Barker, Natalie; Perkins, Edward J.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Lee, Seung-Wuk] Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA. [Lee, Seung-Wuk] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Phys Biosci Div, Berkeley, CA 94720 USA. RP Warner, CM (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM christopher.m.warner@usace.army.mil NR 24 TC 3 Z9 3 U1 4 U2 41 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1615-7591 EI 1615-7605 J9 BIOPROC BIOSYST ENG JI Bioprocess. Biosyst. Eng. PD OCT PY 2014 VL 37 IS 10 BP 2067 EP 2072 DI 10.1007/s00449-014-1184-7 PG 6 WC Biotechnology & Applied Microbiology; Engineering, Chemical SC Biotechnology & Applied Microbiology; Engineering GA AP6EX UT WOS:000342171500016 PM 24728964 ER PT J AU Esposito, ER Blanck, RV Harper, NG Hsu, JR Wilken, JM AF Esposito, Elizabeth Russell Blanck, Ryan V. Harper, Nicole G. Hsu, Joseph R. Wilken, Jason M. TI How Does Ankle-foot Orthosis Stiffness Affect Gait in Patients With Lower Limb Salvage? SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Article ID CHRONICALLY UNSTABLE ANKLE; PLANTARFLEXOR WEAKNESS; ENERGY-COST; PHYSICAL-THERAPY; WALKING; KINEMATICS; CHILDREN; SUPPORT; PERFORMANCE; LOCOMOTION AB Ankle-foot orthoses (AFOs) are commonly prescribed during rehabilitation after limb salvage. AFO stiffness is selected to help mitigate gait deficiencies. A new custom dynamic AFO, the Intrepid Dynamic Exoskeletal Orthosis (IDEO), is available to injured service members but prescription guidelines are limited. In this study we ask (1) does dynamic AFO stiffness affect gait parameters such as joint angles, moments, and powers; and (2) can a given dynamic AFO stiffness normalize gait mechanics to noninjured control subjects? Thirteen patients with lower limb salvage (ankle arthrodesis, neuropathy, foot/ankle reconstruction, etc) after major lower extremity trauma and 13 control subjects who had no lower extremity trauma and wore no orthosis underwent gait analysis at a standardized speed. Patients wore their custom IDEO with posterior struts of three different stiffnesses: nominal (clinically prescribed stiffness), compliant (20% less stiff), and stiff (20% stiffer). Joint angles, moments, powers, and ground reaction forces were compared across the varying stiffnesses of the orthoses tested and between the patient and control groups. An increase in AFO compliance resulted in 20% to 26% less knee flexion relative to the nominal (p = 0.003) and stiff (p = 0.001) conditions, respectively. Ankle range of motion and power generation were, on average, 56% (p < 0.001) and 63% (p < 0.001), respectively, less than controls as a result of the relatively fixed ankle position. Patients with limb salvage readily adapted to different dynamic AFO stiffnesses and demonstrated few biomechanical differences among conditions during walking. None of the stiffness conditions normalized gait to controls. The general lack of differences across a 40% range of strut stiffness suggests that orthotists do not need to invest large amounts of time identifying optimal device stiffness for patients who use dynamic AFOs for low-impact activities such as walking. However, choosing a stiffer strut may more readily translate to higher-impact activities and offer less chance of mechanical failure. C1 [Esposito, Elizabeth Russell; Blanck, Ryan V.; Wilken, Jason M.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ctr Intrepid, Ft Sam Houston, TX 78234 USA. [Blanck, Ryan V.] Hanger Inc, Tacoma, WA USA. [Harper, Nicole G.] Univ Texas Austin, Dept Mech Engn, Cockrell Sch Engn, Austin, TX 78712 USA. [Hsu, Joseph R.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. [Hsu, Joseph R.] Carolinas Med Ctr, Dept Orthoped Surg, Charlotte, NC 28203 USA. RP Wilken, JM (reprint author), Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ctr Intrepid, Ft Sam Houston, TX 78234 USA. EM jason.m.wilken.civ@mail.mil OI Russell Esposito, Elizabeth/0000-0001-5321-0333; Wilken, Jason/0000-0002-5556-7667 FU Center for Rehabilitation Sciences Research (CRSR), Department of Physical Medicine and Rehabilitation, Uniformed Services University of Health Sciences, Bethesda, MD, USA; Smith & Nephew (London, UK) FX Support was provided by the Center for Rehabilitation Sciences Research (CRSR), Department of Physical Medicine and Rehabilitation, Uniformed Services University of Health Sciences, Bethesda, MD, USA (JMW). One of the authors (JRH) certifies that he, or a member of his immediate family, has or may receive payment or benefits during the study period, an amount of USD 10,000 to USD 100,000 from Smith & Nephew (London, UK) Speakers Bureau. NR 42 TC 2 Z9 2 U1 2 U2 15 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0009-921X EI 1528-1132 J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD OCT PY 2014 VL 472 IS 10 BP 3026 EP 3035 DI 10.1007/s11999-014-3661-3 PG 10 WC Orthopedics; Surgery SC Orthopedics; Surgery GA AP2NN UT WOS:000341909300018 ER PT J AU Whitehead, JMA Wolf, EJ Scoville, CR Wilken, JM AF Whitehead, Jennifer M. Aldridge Wolf, Erik J. Scoville, Charles R. Wilken, Jason M. TI Does a Microprocessor-controlled Prosthetic Knee Affect Stair Ascent Strategies in Persons With Transfemoral Amputation? SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Article ID LOWER-LIMB AMPUTEES; BIOMECHANICAL ANALYSIS; HEALTHY-ADULTS; LEVEL WALKING; AMBULATION; JOINT; GAIT; KINEMATICS; PATTERNS; KINETICS AB Stair ascent can be difficult for individuals with transfemoral amputation because of the loss of knee function. Most individuals with transfemoral amputation use either a step-to-step (nonreciprocal, advancing one stair at a time) or skip-step strategy (nonreciprocal, advancing two stairs at a time), rather than a step-over-step (reciprocal) strategy, because step-to-step and skip-step allow the leading intact limb to do the majority of work. A new microprocessor-controlled knee (Ottobock X2(A (R))) uses flexion/extension resistance to allow step-over-step stair ascent. We compared self-selected stair ascent strategies between conventional and X2(A (R)) prosthetic knees, examined between-limb differences, and differentiated stair ascent mechanics between X2(A (R)) users and individuals without amputation. We also determined which factors are associated with differences in knee position during initial contact and swing within X2(A (R)) users. Fourteen individuals with transfemoral amputation participated in stair ascent sessions while using conventional and X2(A (R)) knees. Ten individuals without amputation also completed a stair ascent session. Lower-extremity stair ascent joint angles, moment, and powers and ground reaction forces were calculated using inverse dynamics during self-selected strategy and cadence and controlled cadence using a step-over-step strategy. One individual with amputation self-selected a step-over-step strategy while using a conventional knee, while 10 individuals self-selected a step-over-step strategy while using X2(A (R)) knees. Individuals with amputation used greater prosthetic knee flexion during initial contact (32.5A degrees, p = 0.003) and swing (68.2A degrees, p = 0.001) with higher intersubject variability while using X2(A (R)) knees compared to conventional knees (initial contact: 1.6A degrees, swing: 6.2A degrees). The increased prosthetic knee flexion while using X2(A (R)) knees normalized knee kinematics to individuals without amputation during swing (88.4A degrees, p = 0.179) but not during initial contact (65.7A degrees, p = 0.002). Prosthetic knee flexion during initial contact and swing were positively correlated with prosthetic limb hip power during pull-up (r = 0.641, p = 0.046) and push-up/early swing (r = 0.993, p < 0.001), respectively. Participants with transfemoral amputation were more likely to self-select a step-over-step strategy similar to individuals without amputation while using X2(A (R)) knees than conventional prostheses. Additionally, the increased prosthetic knee flexion used with X2(A (R)) knees placed large power demands on the hip during pull-up and push-up/early swing. A modified strategy that uses less knee flexion can be used to allow step-over-step ascent in individuals with less hip strength. Level II, therapeutic study. See Instructions for Authors for a complete description of levels of evidence. C1 [Whitehead, Jennifer M. Aldridge; Wilken, Jason M.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ctr Intrepid, DOD VA Extrem Trauma & Amputat Ctr Excellence, Ft Sam Houston, TX 78234 USA. [Wolf, Erik J.] Walter Reed Natl Mil Med Ctr, DOD VA Extrem Trauma & Amputat Ctr Excellence, Dept Rehabil, Bethesda, MD USA. [Scoville, Charles R.] Walter Reed Natl Mil Med Ctr, Dept Rehabil, Bethesda, MD USA. RP Wilken, JM (reprint author), Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ctr Intrepid, DOD VA Extrem Trauma & Amputat Ctr Excellence, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Jason.Wilken@us.army.mil OI Wolf, Erik/0000-0002-6353-7978; Wilken, Jason/0000-0002-5556-7667 FU Center for Rehabilitation Sciences Research, Department of Physical Medicine and Rehabilitation, Uniformed Services University of Health Sciences (Bethesda, MD, USA); US Army Telemedicine and Advanced Technology Research Center (Frederick, MD, USA) FX The institution of one or more of the authors (JMW, EJW) has received, during the study period, funding from The Center for Rehabilitation Sciences Research, Department of Physical Medicine and Rehabilitation, Uniformed Services University of Health Sciences (Bethesda, MD, USA).; One or more of the authors (JMW, CRS) certifies that he or she has received, during the study period, funding from the US Army Telemedicine and Advanced Technology Research Center (Frederick, MD, USA). NR 20 TC 3 Z9 3 U1 2 U2 17 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0009-921X EI 1528-1132 J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD OCT PY 2014 VL 472 IS 10 BP 3093 EP 3101 DI 10.1007/s11999-014-3484-2 PG 9 WC Orthopedics; Surgery SC Orthopedics; Surgery GA AP2NN UT WOS:000341909300026 ER PT J AU Heard, WF Martin, BE Nie, X Slawson, T Basu, PK AF Heard, W. F. Martin, B. E. Nie, X. Slawson, T. Basu, P. K. TI Annular Pulse Shaping Technique for Large-Diameter Kolsky Bar Experiments on Concrete SO EXPERIMENTAL MECHANICS LA English DT Article DE Split-hopkinson pressure bar; Pulse shaper; High strength concrete; High rate; Large kolsky bar ID HOPKINSON PRESSURE-BAR; HIGH-STRAIN RATES; COMPRESSIVE BEHAVIOR; DAMAGED CERAMICS; DYNAMIC FAILURE; PLAIN CONCRETE; RADIAL INERTIA; STRENGTH; DEFORMATION; SPECIMENS AB The goal of this study is to design a novel annular pulse shaping technique for large-diameter Kolsky bars for investigating the dynamic compressive response of concretes. The purpose of implementing an annular pulse shaper design is to alleviate inertia-induced stresses in the pulse shaper material that would otherwise superpose unwanted oscillations on the incident wave. This newly developed pulse shaping technique led to well-controlled testing conditions enabling dynamic stress equilibrium, uniform deformation, and constant strain-rate in the testing of a chosen concrete material. The observed dynamic deformation rate of the concrete is highly consistent (8 % variation) with the stress in the specimen well equilibrated confirming the validity of this new technique. Experimental results at both quasi-static (10(-4) s(-1)) and dynamic (100 s(-1), 240 s(-1)) strain rates showed that the failure strength of this concrete is rate-sensitive. C1 [Heard, W. F.; Slawson, T.] US Army Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Martin, B. E.] Air Force Res Lab, Eglin AFB, FL 32542 USA. [Nie, X.] Univ N Texas, Dept Mech & Energy Engn, Denton, TX 76203 USA. [Basu, P. K.] Vanderbilt Univ, Dept Civil & Environm Engn, Nashville, TN 37240 USA. RP Martin, BE (reprint author), Air Force Res Lab, Eglin AFB, FL 32542 USA. EM William.F.Heard@usace.army.mil; bradley.martin@eglin.af.mil; Xu.Nie@unt.edu; p.k.basu@vanderbilt.edu NR 48 TC 3 Z9 3 U1 1 U2 9 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0014-4851 EI 1741-2765 J9 EXP MECH JI Exp. Mech. PD OCT PY 2014 VL 54 IS 8 BP 1343 EP 1354 DI 10.1007/s11340-014-9899-6 PG 12 WC Materials Science, Multidisciplinary; Mechanics; Materials Science, Characterization & Testing SC Materials Science; Mechanics GA AP1FO UT WOS:000341812900004 ER PT J AU Lund, BJ Lund, DJ Edsall, PR AF Lund, Brian J. Lund, David J. Edsall, Peter R. TI DAMAGE THRESHOLD FROM LARGE RETINAL SPOT SIZE REPETITIVE-PULSE LASER EXPOSURES SO HEALTH PHYSICS LA English DT Article DE lasers; maximum permissible exposure; radiation damage; radiation; non-ionizing ID PIGMENT-EPITHELIUM; TIME REGIMEN; INJURY; CELLS AB The retinal damage thresholds for large spot size, multiple-pulse exposures to a Q-switched, frequency doubled Nd: YAG laser (532 nm wavelength, 7 ns pulses) have been measured for 100 mu m and 500 mu m retinal irradiance diameters. The ED50, expressed as energy per pulse, varies only weakly with the number of pulses, n, for these extended spot sizes. The previously reported threshold for a multiple-pulse exposure for a 900 mu m retinal spot size also shows the same weak dependence on the number of pulses. The multiple-pulse ED50 for an extended spot-size exposure does not follow the n(-1/4) dependence exhibited by small spot size exposures produced by a collimated beam. Curves derived by using probability-summation models provide a better fit to the data. C1 [Lund, Brian J.; Lund, David J.; Edsall, Peter R.] US Army, Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA. RP Lund, BJ (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA. EM brian.j.lund@us.army.mil NR 30 TC 2 Z9 2 U1 1 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0017-9078 EI 1538-5159 J9 HEALTH PHYS JI Health Phys. PD OCT PY 2014 VL 107 IS 4 BP 292 EP 299 DI 10.1097/HP.0000000000000121 PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA AP2EC UT WOS:000341884300002 PM 25162419 ER PT J AU Krzych, U Zarling, S Pichugin, A AF Krzych, Urszula Zarling, Stasya Pichugin, Alexander TI Memory T cells maintain protracted protection against malaria SO IMMUNOLOGY LETTERS LA English DT Article; Proceedings Paper CT 15th International Congress of Immunology (ICI) CY AUG 22-27, 2013 CL Milan, ITALY DE Memory T cells; Malaria; Plasmodium; Liver; Mouse model; CD8T cells ID PLASMODIUM-FALCIPARUM SPOROZOITES; INFLUENZA-VIRUS INFECTION; LIVER STAGE ANTIGEN-1; NITRIC-OXIDE SYNTHASE; IFN-GAMMA RESPONSES; BERGHEI SPOROZOITES; IN-VIVO; IRRADIATED SPOROZOITES; VACCINE DEVELOPMENT; INTERFERON-GAMMA AB Immunologic memory is one of the cardinal features of antigen-specific immune responses, and the persistence of memory cells contributes to prophylactic immunizations against infectious agents. Adequately maintained memory T and B cell pools assure a fast, effective and specific response against re-infections. However, many aspects of immunologic memory are still poorly understood, particularly immunologic memory inducible by parasites, for example, Plasmodium spp., the causative agents of malaria. For example, memory responses to Plasmodium antigens amongst residents of malaria endemic areas appear to be either inadequately developed or maintained, because persons who survive episodes of childhood malaria remain vulnerable to intermittent malaria infections. By contrast, multiple exposures of humans and laboratory rodents to radiation-attenuated Plasmodium sporozoites (gamma-spz) induce sterile and long-lasting protection against experimental sporozoite challenge. Multifactorial immune mechanisms maintain this protracted and sterile protection. While the presence of memory CD4 T cell subsets has been associated with lasting protection in humans exposed to multiple bites from Anopheles mosquitoes infected with attenuated Plasmodium falciparum, memory CD8 T cells maintain protection induced with Plasmodium yoelii and Plasmodium berghei gamma-spz in murine models. In this review, we discuss our observations that show memory CD8 T cells specific for antigens expressed by P. berghei liver stage parasites as an indispensable component for the maintenance of protracted protective immunity against experimental malaria infection; moreover, the provision of an Ag-depot assures a quick recall of memory T cells as IFN-gamma-producing effector CD8 T cells and IL-4- producing CD4 T cells that collaborate with B cells for an effective antibody response. (C) 2014 Published by Elsevier B.V. C1 [Krzych, Urszula; Zarling, Stasya; Pichugin, Alexander] Walter Reed Army Inst Res, Dept Cellular Immunol, Branch Malaria Vaccine Dev, Silver Spring, MD 20910 USA. RP Krzych, U (reprint author), Walter Reed Army Inst Res, Dept Cellular Immunol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Urszula.Krzych1.civ@mail.mil OI Pichugin, Alexander/0000-0002-2577-7284 NR 122 TC 7 Z9 7 U1 0 U2 19 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-2478 EI 1879-0542 J9 IMMUNOL LETT JI Immunol. Lett. PD OCT PY 2014 VL 161 IS 2 SI SI BP 189 EP 195 DI 10.1016/j.imlet.2014.03.011 PG 7 WC Immunology SC Immunology GA AP7IW UT WOS:000342252000006 PM 24709142 ER PT J AU Barry, BE AF Barry, Brock E. TI Special Section on Curriculum Assessment and Continuous Improvement SO JOURNAL OF PROFESSIONAL ISSUES IN ENGINEERING EDUCATION AND PRACTICE LA English DT Editorial Material C1 US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. RP Barry, BE (reprint author), US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. EM brock.barry@usma.edu NR 0 TC 0 Z9 0 U1 1 U2 3 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1052-3928 EI 1943-5541 J9 J PROF ISS ENG ED PR JI J. Prof. Issues Eng. Educ. Pract. PD OCT PY 2014 VL 140 IS 4 AR A2014001 DI 10.1061/(ASCE)EI.1943-5541.0000221 PG 1 WC Education, Scientific Disciplines; Engineering, Multidisciplinary SC Education & Educational Research; Engineering GA AP6YS UT WOS:000342225200006 ER PT J AU Kanjilal, B Keyser, BM Andres, DK Nealley, E Benton, B Melber, AA Andres, JF Letukas, VA Clark, O Ray, R AF Kanjilal, Baishali Keyser, Brian M. Andres, Devon K. Nealley, Eric Benton, Betty Melber, Ashley A. Andres, Jaclynn F. Letukas, Valerie A. Clark, Offie Ray, Radharaman TI Differentiated NSC-34 cells as an in vitro cell model for VX SO TOXICOLOGY MECHANISMS AND METHODS LA English DT Article DE Cell death; nerve agent; NSC-34 cells; VX ID NEURONAL DEATH; LINE; MECHANISMS; APOPTOSIS; RECEPTOR; RELEASE; AIF AB The US military has placed major emphasis on developing therapeutics against nerve agents (NA). Current efforts are hindered by the lack of effective in vitro cellular models to aid in the preliminary screening of potential candidate drugs/antidotes. The development of an in vitro cellular model to aid in discovering new NA therapeutics would be highly beneficial. In this regard, we have examined the response of a differentiated hybrid neuronal cell line, NSC-34, to the NA VX. VX-induced apoptosis of differentiated NSC-34 cells was measured by monitoring the changes in caspase-3 and caspase-9 activity post-exposure. Differentiated NSC-34 cells showed an increase in caspase-3 activity in a manner dependent on both time (17-23 h post-exposure) and dose (10-100 nM). The maximal increase in caspase-3 activity was found to be at 20-h post-exposure. Caspase-9 activity was also measured in response to VX and was found to be elevated at all concentrations (10-100 nM) tested. VX-induced cell death was also observed by utilizing annexin V/propidium iodide flow cytometry. Finally, VX-induced caspase-3 or -9 activities were reduced with the addition of pralidoxime (2-PAM), one of the current therapeutics used against NA toxicity, and dizocilpine (MK-801). Overall the data presented here show that differentiated NSC-34 cells are sensitive to VX-induced cell death and could be a viable in vitro cell model for screening NA candidate therapeutics. C1 [Kanjilal, Baishali] US Army Med Res Inst Chem Def, Pharmacol & Immunol Branch, Aberdeen Proving Ground, MD 21010 USA. [Keyser, Brian M.; Andres, Devon K.; Nealley, Eric; Benton, Betty; Melber, Ashley A.; Andres, Jaclynn F.; Letukas, Valerie A.; Clark, Offie; Ray, Radharaman] US Army Med Res Inst Chem Def, Div Res, Cellular & Mol Biol Branch, Aberdeen Proving Ground, MD 21010 USA. RP Ray, R (reprint author), US Army Med Res Inst Chem Def, Div Res, Cellular & Mol Biol Branch, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM radharaman.ray.civ@mail.mil OI Andres, Devon/0000-0002-6823-4132 FU Defense Threat Reduction Agency - Joint Science and Technology Office, Medical ST Division; U.S. Army Medical Research Institute of Chemical Defense FX This work was supported by the Defense Threat Reduction Agency - Joint Science and Technology Office, Medical S&T Division. Additionally, this research was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Medical Research Institute of Chemical Defense administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USAMRMC. The views expressed in this article are those of the authors and do not reflect the official policy of the Department of Army, Department of Defense, or the U.S. Government. NR 18 TC 2 Z9 2 U1 0 U2 2 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1537-6516 EI 1537-6524 J9 TOXICOL MECH METHOD JI Toxicol. Mech. Methods PD OCT PY 2014 VL 24 IS 7 BP 488 EP 494 DI 10.3109/15376516.2014.943442 PG 7 WC Toxicology SC Toxicology GA AP7CK UT WOS:000342235100005 PM 25045830 ER PT J AU Co, MDT Terajima, M Thomas, SJ Jarman, RG Rungrojcharoenkit, K Fernandez, S Yoon, IK Buddhari, D Cruz, J Ennis, FA AF Co, Mary Dawn T. Terajima, Masanori Thomas, Stephen J. Jarman, Richard G. Rungrojcharoenkit, Kamonthip Fernandez, Stefan Yoon, In-Kyu Buddhari, Darunee Cruz, John Ennis, Francis A. TI Relationship of Preexisting Influenza Hemagglutination Inhibition, Complement-Dependent Lytic, and Antibody-Dependent Cellular Cytotoxicity Antibodies to the Development of Clinical Illness in a Prospective Study of A(H1N1)pdm09 Influenza in Children SO VIRAL IMMUNOLOGY LA English DT Article ID MEDIATED CYTO-TOXICITY; VIRUS-INFECTION; A VIRUSES; PROTECTION; CELLS; RESPONSES; NEUTRALIZATION; EXPRESSION; IMMUNITY; MEASLES AB The hemagglutination inhibition (HAI) antibody titer is considered the primary immune correlate of protection for influenza. However, recent studies have highlighted the limitations on the use of the HAI titer as a correlate in at-risk populations such as children and older adults. In addition to the neutralization of cell-free virus by antibodies to hemagglutinin and interference of virus release from infected cells by antibodies to neuraminidase, influenza virus-specific antibodies specifically can bind to infected cells and lyse virus-infected cells through the activation of complement or natural killer (NK) cells, via antibody-dependent cellular cytotoxicity (ADCC) or complement-dependent lysis (CDL). We evaluated preexisting HAI, CDL, and ADCC antibodies in young children enrolled in a prospective cohort study of dengue during the epidemic with influenza A(H1N1)pdm09 virus to determine associations between preexisting antibodies and the occurrence of clinical or subclinical influenza virus infection. Though both preexisting HAI and CDL antibodies were associated with protection against clinical influenza, our data suggested that CDL was not a better correlate than HAI. We found that ADCC antibodies behaved differently from HAI and CDL antibodies. Unlike HAI and CDL antibodies, preexisting ADCC antibodies did not correlate with protection against clinical influenza. In fact, ADCC antibodies were detected more frequently in the clinical influenza group than the subclinical group. In addition, in contrast to HAI and CDL antibodies, HAI and the ADCC antibodies titers did not correlate. We also found that ADCC, but not CDL or HAI antibodies, positively correlated with the ages of the children. C1 [Co, Mary Dawn T.; Terajima, Masanori; Cruz, John; Ennis, Francis A.] Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01655 USA. [Thomas, Stephen J.; Jarman, Richard G.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA. [Rungrojcharoenkit, Kamonthip; Fernandez, Stefan; Yoon, In-Kyu; Buddhari, Darunee] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. RP Co, MDT (reprint author), Univ Massachusetts, Sch Med, 55 Lake Ave North, Worcester, MA 01655 USA. EM mary.co@umassmed.edu FU National Institutes of Health, Military Infectious Disease Program [U19 AI57319, 5P01 AI034533]; Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center FX This work was supported by the National Institutes of Health (U19 AI57319 and 5P01 AI034533), the Military Infectious Disease Program, and by the Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center. We would like to acknowledge Dr. Alan Rothman for assistance with the logistics for this study. We thank Dr. Robert Ryall from Sanofi Pasteur for his gift of the A/California/7/09 strain used in the CDL and ADCC assays. We would also like to acknowledge Dr. Louise Maranda for her advice on the statistical analysis of the data, and Dr. Jin-Sheng Wen for establishing the ADCC assay. The views expressed in this article are those of the authors and do not represent the official policy or position of the U. S. Department of the Army, Department of Defense, or U.S. Government or the Royal Thai Army. NR 30 TC 7 Z9 7 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0882-8245 EI 1557-8976 J9 VIRAL IMMUNOL JI Viral Immunol. PD OCT 1 PY 2014 VL 27 IS 8 BP 375 EP 382 DI 10.1089/vim.2014.0061 PG 8 WC Immunology; Virology SC Immunology; Virology GA AQ0YE UT WOS:000342507800003 PM 25141276 ER PT J AU Welsh, SK Gross, JE Larson, NS Berg, JM Roy, D Pinsker, JE AF Welsh, Sebastian K. Gross, Jane E. Larson, Noelle S. Berg, Janet M. Roy, Daniel Pinsker, Jordan E. TI False-Negative Sweat Chloride Testing in a Child With Cystic Fibrosis and Undiagnosed Hypohidrotic Ectodermal Dysplasia SO CLINICAL PEDIATRICS LA English DT Article ID MUTATIONS; GUIDELINES; DIAGNOSIS; ABSENCE C1 [Welsh, Sebastian K.; Gross, Jane E.; Larson, Noelle S.; Berg, Janet M.; Roy, Daniel; Pinsker, Jordan E.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Welsh, SK (reprint author), Tripler Army Med Ctr, Dept Pediat, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM sebastian.k.welsh.mil@mail.mil OI Pinsker, Jordan/0000-0003-4080-9034 NR 11 TC 1 Z9 1 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0009-9228 EI 1938-2707 J9 CLIN PEDIATR JI Clin. Pediatr. PD OCT PY 2014 VL 53 IS 12 BP 1203 EP 1205 DI 10.1177/0009922813518426 PG 3 WC Pediatrics SC Pediatrics GA AP2CS UT WOS:000341880700012 PM 24419263 ER PT J AU Pfannenstiel, TJ AF Pfannenstiel, Travis J. TI Noise-induced hearing loss: a military perspective SO CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY LA English DT Review DE hearing protection; mathematical modeling; military service; noise-induced hearing loss ID IMPULSE NOISE; PERSONNEL; EXPOSURE; BLAST AB Purpose of review To summarize relevant literature occurring over the past 12-18 months forwarding understanding of noise-induced hearing loss in relation to military service. Recent findings Hearing loss prior to entry into military service is highly predictive of subsequent hearing loss and hearing loss disability. Tightly controlled organic solvent exposure may not be a significant risk factor for noise-induced hearing loss. Increasingly detailed analysis of high intensity noise, impulse and blast noise exposures, and the methods used to mitigate these exposures are leading to breakthroughs in understanding and predicting hearing loss in military service. Summary Prevention, mitigation, treatment, and prediction of the effects of hazardous noise exposure in military service continue to require a multidisciplinary team of individuals from around the world fully aware of the detrimental effect to service members and their societies of hearing loss disability. C1 Brooke Army Med Ctr, Dept Otolaryngol, Jbsa Ft Sam Houston, TX 78234 USA. RP Pfannenstiel, TJ (reprint author), Brooke Army Med Ctr, Dept Otolaryngol, 3551 Roger Brooke Dr, Jbsa Ft Sam Houston, TX 78234 USA. EM tpotology@gmail.com NR 14 TC 0 Z9 0 U1 4 U2 18 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1068-9508 EI 1531-6998 J9 CURR OPIN OTOLARYNGO JI Curr. Opin. Otolaryngol. Head Neck Surg. PD OCT PY 2014 VL 22 IS 5 BP 384 EP 387 DI 10.1097/MOO.0000000000000083 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA AP1TN UT WOS:000341854400009 PM 25188428 ER PT J AU Adler, AB Saboe, KN Anderson, J Sipos, ML Thomas, JL AF Adler, Amy B. Saboe, Kristin N. Anderson, James Sipos, Maurice L. Thomas, Jeffrey L. TI Behavioral Health Leadership: New Directions in Occupational Mental Health SO CURRENT PSYCHIATRY REPORTS LA English DT Article DE Leadership; Deployment; Occupational health; Combat operational stress control; Afghanistan; Soldiers; PTSD; Anxiety; Depression; Care seeking ID POSTTRAUMATIC-STRESS-DISORDER; TRANSFORMATIONAL LEADERSHIP; SAFETY LEADERSHIP; EMPLOYEE SAFETY; WAR VETERANS; SOLDIERS; IRAQ; CLIMATE; STIGMA; CARE AB The impact of stress on mental health in high-risk occupations may be mitigated by organizational factors such as leadership. Studies have documented the impact of general leadership skills on employee performance and mental health. Other researchers have begun examining specific leadership domains that address relevant organizational outcomes, such as safety climate leadership. One emerging approach focuses on domain-specific leadership behaviors that may moderate the impact of combat deployment on mental health. In a recent study, US soldiers deployed to Afghanistan rated leaders on behaviors promoting management of combat operational stress. When soldiers rated their leaders high on these behaviors, soldiers also reported better mental health and feeling more comfortable with the idea of seeking mental health treatment. These associations held even after controlling for overall leadership ratings. Operational stress leader behaviors also moderated the relationship between combat exposure and soldier health. Domain-specific leadership offers an important step in identifying measures to moderate the impact of high-risk occupations on employee health. C1 [Adler, Amy B.; Thomas, Jeffrey L.] Walter Reed Army Inst Res, US Army Med Res Unit Europe, Sembach, Germany. [Saboe, Kristin N.; Anderson, James; Sipos, Maurice L.] Walter Reed Army Inst Res, Mil Psychiat Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. RP Adler, AB (reprint author), Walter Reed Army Inst Res, US Army Med Res Unit Europe, Sembach, Germany. EM amy.b.adler.civ@mail.mil; Kristin.n.saboe.mil@mail.mil; james.a.anderson481.mil@mail.mil; Maurice.l.sipos.mil@mail.mil; Jeffrey.l.thomas.mil@mail.mil FU U.S. Army Military Operational Medicine Research Program FX The views expressed in this article are those of the authors and do not necessarily represent the official policy or position of the U. S. Army Medical Command or the US Army. The study was approved by the Institutional Review Board at the Walter Reed Army Institute of Research. Funding was received from the U.S. Army Military Operational Medicine Research Program. The authors report no competing interests. Thanks to Paul Kim for editorial assistance. NR 61 TC 1 Z9 1 U1 3 U2 24 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1523-3812 EI 1535-1645 J9 CURR PSYCHIAT REP JI Curr. Psychiatry Rep. PD OCT PY 2014 VL 16 IS 10 AR 484 DI 10.1007/s11920-014-0484-6 PG 7 WC Psychiatry SC Psychiatry GA AP1KG UT WOS:000341827500012 PM 25160794 ER PT J AU Austin, KG McGraw, SM Lieberman, HR AF Austin, Krista G. McGraw, Susan M. Lieberman, Harris R. TI Multivitamin and Protein Supplement Use Is Associated With Positive Mood States and Health Behaviors in US Military and Coast Guard Personnel SO JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY LA English DT Article DE amino acids; steroids; aggressive; depression; alertness; Army; Air Force; herbal ID ANDROGENIC STEROID USE; DIETARY-SUPPLEMENTS; VITAMIN AB Approximately 60% of Armed Forces personnel regularly consume dietary supplements (DSs). We investigated the association of mood and health behaviors with multiple classes of DSs in military and Coast Guard personnel (N = 5536). Participants completed a survey of DS use and the Quick Mood Scale to assess mood domains of wakeful-drowsiness, relaxed-anxious, cheerful-depressed, friendly-aggression, clearheaded-confused, and well coordinated-clumsy. Supplements were categorized as multivitamin/minerals (MVM), individual vitamin/minerals, protein/amino acid supplements (PS), combination products (C), herbals (H), purported steroid analogs, (S) and other (O). One-way analyses of covariance assessed associations of DSs and perceived health behavior with mood controlling for age. Logistic regression determined associations between DS use and health behavior. Users of MVM and PS reported feeling significantly (P < 0.05) more awake, relaxed, cheerful, clearheaded, and coordinated. Participants using PS and S reported feeling less friendly (more aggressive, P < 0.02). Users of MVM and PS were more likely to report their general health, eating habits, and fitness level as excellent/good (P < 0.05). Participants reporting health behaviors as excellent/good were more (P < 0.01) awake, relaxed, cheerful, friendly, clearheaded, and coordinated. As no known biological mechanisms can explain such diverse effects of MVM and PS use on multiple mood states, health, eating habits, and fitness, we hypothesize these associations are not causal, and DS intake does not alter these parameters per se. Preexisting differences in mood and other health-related behaviors and outcomes between users versus nonusers of DSs could be a confounding factor in studies of DSs. C1 [Austin, Krista G.; McGraw, Susan M.; Lieberman, Harris R.] US Army Res Inst Environm Med, Natick, MA 01760 USA. [Austin, Krista G.] Oak Ridge Inst Sci & Educ, Belcamp, MD USA. RP Lieberman, HR (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. EM harris.r.lieberman.civ@mail.mil FU US Army Research and Material Command; Department of Defense Center Alliance for Dietary Supplement Research FX This work was supported by the US Army Research and Material Command and the Department of Defense Center Alliance for Dietary Supplement Research. NR 32 TC 1 Z9 1 U1 0 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0271-0749 EI 1533-712X J9 J CLIN PSYCHOPHARM JI J. Clin. Psychopharmacol. PD OCT PY 2014 VL 34 IS 5 BP 595 EP 601 DI 10.1097/JCP.0000000000000193 PG 7 WC Pharmacology & Pharmacy; Psychiatry SC Pharmacology & Pharmacy; Psychiatry GA AP1EO UT WOS:000341809700011 PM 25122181 ER PT J AU Killgore, WDS Kamimori, GH Balkin, TJ AF Killgore, William D. S. Kamimori, Gary H. Balkin, Thomas J. TI Caffeine Improves the Efficiency of Planning and Sequencing Abilities During Sleep Deprivation SO JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY LA English DT Letter ID DECISION-MAKING; PERFORMANCE; MODAFINIL; DEXTROAMPHETAMINE; WAKEFULNESS; STIMULANTS; MOOD C1 [Killgore, William D. S.] McLean Hosp, Belmont, MA 02178 USA. [Killgore, William D. S.] Harvard Univ, Sch Med, Boston, MA USA. [Kamimori, Gary H.; Balkin, Thomas J.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Killgore, WDS (reprint author), McLean Hosp, 115 Mill St, Belmont, MA 02178 USA. EM killgore@mclean.harvard.edu OI Killgore, William/0000-0002-5328-0208 NR 16 TC 2 Z9 2 U1 1 U2 14 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0271-0749 EI 1533-712X J9 J CLIN PSYCHOPHARM JI J. Clin. Psychopharmacol. PD OCT PY 2014 VL 34 IS 5 BP 660 EP 662 PG 4 WC Pharmacology & Pharmacy; Psychiatry SC Pharmacology & Pharmacy; Psychiatry GA AP1EO UT WOS:000341809700030 PM 25058815 ER PT J AU Hout, JJ White, DW Stubner, A Stevens, M Knapik, JJ AF Hout, Joseph J. White, Duvel W. Stubner, Alex Stevens, Michael Knapik, Joseph J. TI O-Chlorobenzylidene Malononitrile (CS Riot Control Agent) Exposure in a US Army Basic Combat Training Cohort SO JOURNAL OF ENVIRONMENTAL HEALTH LA English DT Article ID NEW-ORLEANS; TEAR GAS; HEALTH; PREVALENCE; HUMIDITY; CHILDREN; MOISTURE; ALLERGEN; DAMPNESS; ASTHMA AB All U.S. Army soldiers participate in mask confidence training during initial military training and periodically throughout their careers. Training is conducted by dispersing the riot control agent, o-chlorobenzylidene malononitrile (CS), in a relatively air-tight structure where soldiers enter and conduct a series of exercises that culminate with mask removal. The study described here quantified CS concentrations experienced by 6,723 trainees and seven chamber operators during U.S. Army basic combat training at Fort Jackson, South Carolina, from August 1 to September 25, 2012. All 6,723 trainees were potentially exposed to CS concentrations exceeding the American Conference of Governmental Industrial Hygienists threshold limit value-ceiling (TLV-C) (0.39 mg/m(3)), 6,589 of which were potentially exposed to concentrations exceeding the value deemed immediately dangerous to life and health (IDLH) (2.0 mg/m(3)) by the National Institute for Occupational Safety and Health. All chamber operators were exposed to concentrations exceeding both the TLV-C and the IDLH. C1 [Hout, Joseph J.; White, Duvel W.; Stubner, Alex; Stevens, Michael] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Knapik, Joseph J.] US Army, Inst Publ Hlth, Washington, DC USA. RP Hout, JJ (reprint author), Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM jhout@usuhs.edu FU National Institutes of Health [HHSN275200800027C/N01-HD-80027] FX Support for this project was provided by the National Institutes of Health contract HHSN275200800027C/N01-HD-80027. The authors of this manuscript did not receive any financial support from the commercial manufacturers of the instruments evaluated and believe no conflicts of interest exist. The authors would also like to thank the volunteers who opened their homes for data collection. NR 64 TC 2 Z9 2 U1 0 U2 8 PU NATL ENVIRON HEALTH ASSOC PI DENVER PA 720 S COLORADO BLVD SUITE 970, SOUTH TOWER, DENVER, CO 80246 USA SN 0022-0892 J9 J ENVIRON HEALTH JI J. Environ. Health PD OCT PY 2014 VL 77 IS 3 BP 14 EP 28 PG 13 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AP3FI UT WOS:000341960600003 PM 25603650 ER PT J AU Pan, ZL Kecskes, LJ Wei, QM AF Pan, Zhiliang Kecskes, Laszlo J. Wei, Qiuming TI The nature behind the preferentially embrittling effect of impurities on the ductility of tungsten SO COMPUTATIONAL MATERIALS SCIENCE LA English DT Article DE Ductility; First principles calculations; Segregation; Grain boundary; Dislocation ID ATOMISTIC SIMULATION; SCREW DISLOCATIONS; GRAIN-BOUNDARIES; TRANSITION; SEGREGATION; DECOHESION; COHESION; TANTALUM; METALS; COPPER AB It is well known that the ductility of tungsten is very sensitive to impurities while the ductility of tantalum is tolerant to them. However, the fundamental reason behind this preferential effect still remains elusive. Here, based on first-principles calculations, we demonstrated that impurities in tungsten are more likely to segregate into the investigated grain boundary region and the vicinity of straight screw dislocation core than in tantalum, thus having more chances to decrease the ductility. In turn, the presence of impurities, if deemed undesirable, will cause a greater reduction in the grain boundary separation energy for tungsten. The analyses of the chemical and mechanical effects of impurities based on an elegant model suggest that, for the deleterious impurities that have similar binding behavior with tantalum and tungsten, if their effect is repulsive at all relevant site, tungsten is more sensitive to them due to its low lattice constant and high elastic modulus despite other possible causes. (C) 2014 Elsevier B.V. All rights reserved. C1 [Pan, Zhiliang; Wei, Qiuming] Univ N Carolina, Dept Mech Engn & Engn Sci, Charlotte, NC 28223 USA. [Pan, Zhiliang] Cornell Univ, Sch Civil & Environm Engn, Ithaca, NY 14853 USA. [Pan, Zhiliang] Univ Calif Irvine, Dept Mech & Aerosp Engn, Irvine, CA 92697 USA. [Kecskes, Laszlo J.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Pan, ZL (reprint author), Univ Calif Irvine, Dept Mech & Aerosp Engn, Irvine, CA 92697 USA. EM zhilianp@uci.edu RI Wei, Qiuming/B-7579-2008; Pan, Zhiliang/A-8061-2009 OI Pan, Zhiliang/0000-0003-3899-8761 FU U.S. Army Research Laboratory (ARL) [W911QX-06-C-0124, W911QX-08-C-0073] FX The authors acknowledge the financial support from the U.S. Army Research Laboratory (ARL) under Contract Nos. W911QX-06-C-0124 and W911QX-08-C-0073, and the technical support from the University Research Computing Group at UNC Charlotte for providing the high-performance computing environment and excellent consulting and assistance to this work. NR 31 TC 4 Z9 4 U1 3 U2 22 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0927-0256 EI 1879-0801 J9 COMP MATER SCI JI Comput. Mater. Sci. PD OCT PY 2014 VL 93 BP 104 EP 111 DI 10.1016/j.commatsci.2014.06.036 PG 8 WC Materials Science, Multidisciplinary SC Materials Science GA AO6PT UT WOS:000341474700018 ER PT J AU Ketter, T Pikalov, A Sarma, K Silva, R Kroger, H Cucchiaro, J Loebel, A AF Ketter, T. Pikalov, A. Sarma, K. Silva, R. Kroger, H. Cucchiaro, J. Loebel, A. TI Lurasidone in bipolar I depression: a 24 week, open-label extension study SO EUROPEAN NEUROPSYCHOPHARMACOLOGY LA English DT Meeting Abstract CT 27th Congress of the European-College-of-Neuropsychopharmacology (ECNP) CY OCT 18-21, 2014 CL Berlin, GERMANY SP European Coll Neuropsychopharmacol ID DOUBLE-BLIND C1 [Ketter, T.] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA. [Pikalov, A.; Sarma, K.; Silva, R.; Kroger, H.; Cucchiaro, J.; Loebel, A.] Sunovion Pharmaceut Inc, Clin Dev & Med Affairs, Ft Lee, VA USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0924-977X EI 1873-7862 J9 EUR NEUROPSYCHOPHARM JI Eur. Neuropsychopharmacol. PD OCT PY 2014 VL 24 SU 2 MA P.2.d.051 BP S443 EP S444 PG 2 WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA CT5LL UT WOS:000362851700198 ER PT J AU Loebel, A Siu, C Cucchiaro, J Pikalov, A Harvey, P AF Loebel, A. Siu, C. Cucchiaro, J. Pikalov, A. Harvey, P. TI Evaluation of daytime sleepiness in patients with schizophrenia treated with atypical antipsychotics SO EUROPEAN NEUROPSYCHOPHARMACOLOGY LA English DT Meeting Abstract CT 27th Congress of the European-College-of-Neuropsychopharmacology (ECNP) CY OCT 18-21, 2014 CL Berlin, GERMANY SP European Coll Neuropsychopharmacol ID EFFICACY C1 [Loebel, A.] Sunov Pharmaceut Inc, Marlborough, MA USA. [Siu, C.] Data Power Inc, Data Sci, Flemington, NJ USA. [Cucchiaro, J.] Sunov Pharmaceut Inc, Clin Operat, Ft Lee, VA USA. [Pikalov, A.] Sunov Pharmaceut Inc, Med Affairs, Ft Lee, VA USA. [Harvey, P.] Univ Miami, Miller Sch Med, Med, Miami, FL 33136 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0924-977X EI 1873-7862 J9 EUR NEUROPSYCHOPHARM JI Eur. Neuropsychopharmacol. PD OCT PY 2014 VL 24 SU 2 MA P.3.d.065 BP S561 EP S561 PG 1 WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA CT5LM UT WOS:000362851800031 ER PT J AU Mattingly, G Tocco, M Cucchiaro, J Xu, J Pikalov, A Loebel, A AF Mattingly, G. Tocco, M. Cucchiaro, J. Xu, J. Pikalov, A. Loebel, A. TI An open-label extension study of lurasidone in patients with schizophrenia previously randomized to lurasidone or risperidone SO EUROPEAN NEUROPSYCHOPHARMACOLOGY LA English DT Meeting Abstract CT 27th Congress of the European-College-of-Neuropsychopharmacology (ECNP) CY OCT 18-21, 2014 CL Berlin, GERMANY SP European Coll Neuropsychopharmacol C1 [Mattingly, G.] St Charles Psychiat Associates, St Charles, MO USA. [Tocco, M.] Sunov Pharmaceut Inc, Marlborough, MA USA. [Cucchiaro, J.; Xu, J.; Pikalov, A.; Loebel, A.] Sunov Pharmaceut Inc, Ft Lee, VA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0924-977X EI 1873-7862 J9 EUR NEUROPSYCHOPHARM JI Eur. Neuropsychopharmacol. PD OCT PY 2014 VL 24 SU 2 MA P.3.d.062 BP S559 EP S559 PG 1 WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA CT5LM UT WOS:000362851800028 ER PT J AU Newcomer, J Pikalov, A Watabe, K Cucchiaro, J Rajagopalan, K Loebel, A AF Newcomer, J. Pikalov, A. Watabe, K. Cucchiaro, J. Rajagopalan, K. Loebel, A. TI Effect of lurasidone or risperidone on metabolic syndrome status in patients with schizophrenia: a post hoc analysis of a long-term study SO EUROPEAN NEUROPSYCHOPHARMACOLOGY LA English DT Meeting Abstract CT 27th Congress of the European-College-of-Neuropsychopharmacology (ECNP) CY OCT 18-21, 2014 CL Berlin, GERMANY SP European Coll Neuropsychopharmacol C1 [Newcomer, J.] Florida Atlantic Univ, Boca Raton, FL 33431 USA. [Pikalov, A.; Watabe, K.; Cucchiaro, J.; Loebel, A.] Sunov Pharmaceut Inc, Ft Lee, VA USA. [Rajagopalan, K.] Sunov Pharmaceut Inc, Marlborough, MA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0924-977X EI 1873-7862 J9 EUR NEUROPSYCHOPHARM JI Eur. Neuropsychopharmacol. PD OCT PY 2014 VL 24 SU 2 MA P.3.d.061 BP S558 EP S559 PG 2 WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA CT5LM UT WOS:000362851800027 ER PT J AU Schooler, NR Pikalov, A Hsu, J Cucchiaro, J Goldman, R Loebel, A AF Schooler, N. R. Pikalov, A. Hsu, J. Cucchiaro, J. Goldman, R. Loebel, A. TI Efficacy of lurasidone in the treatment of schizophrenia with prominent negative symptoms: a post-hoc analysis of five short-term trials SO EUROPEAN NEUROPSYCHOPHARMACOLOGY LA English DT Meeting Abstract CT 27th Congress of the European-College-of-Neuropsychopharmacology (ECNP) CY OCT 18-21, 2014 CL Berlin, GERMANY SP European Coll Neuropsychopharmacol C1 [Schooler, N. R.] Suny Downstate Med Ctr, Dept Psychiat & Behav Sci, Brooklyn, NY 11203 USA. [Pikalov, A.; Hsu, J.; Cucchiaro, J.; Loebel, A.] Sunov Pharmaceut Inc, Clin Dev & Med Affairs, Ft Lee, VA USA. [Goldman, R.] Sunov Pharmaceut Inc, Med Affairs, Marlborough, MA USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0924-977X EI 1873-7862 J9 EUR NEUROPSYCHOPHARM JI Eur. Neuropsychopharmacol. PD OCT PY 2014 VL 24 SU 2 MA P.3.d.060 BP S558 EP S558 PG 1 WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA CT5LM UT WOS:000362851800026 ER PT J AU Tandon, R Loebel, A Phillips, D Pikalov, A Hernandez, D Mao, Y Cucchiaro, J AF Tandon, R. Loebel, A. Phillips, D. Pikalov, A. Hernandez, D. Mao, Y. Cucchiaro, J. TI Lurasidone for maintenance of efficacy in patients with schizophrenia: a double-blind, placebo-controlled, randomised withdrawal study SO EUROPEAN NEUROPSYCHOPHARMACOLOGY LA English DT Meeting Abstract CT 27th Congress of the European-College-of-Neuropsychopharmacology (ECNP) CY OCT 18-21, 2014 CL Berlin, GERMANY SP European Coll Neuropsychopharmacol C1 [Tandon, R.] Univ Florida, Coll Med, Gainesville, FL USA. [Loebel, A.; Phillips, D.; Pikalov, A.; Hernandez, D.; Mao, Y.; Cucchiaro, J.] Sunov Pharmaceut Inc, Ft Lee, VA USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0924-977X EI 1873-7862 J9 EUR NEUROPSYCHOPHARM JI Eur. Neuropsychopharmacol. PD OCT PY 2014 VL 24 SU 2 MA P.3.d.063 BP S559 EP S560 PG 2 WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA CT5LM UT WOS:000362851800029 ER PT J AU Thase, M Tsai, J Kroger, H Pikalov, A Cucchiaro, J Loebel, A AF Thase, M. Tsai, J. Kroger, H. Pikalov, A. Cucchiaro, J. Loebel, A. TI Lurasidone treatment for bipolar I depression: effect on core depression symptoms SO EUROPEAN NEUROPSYCHOPHARMACOLOGY LA English DT Meeting Abstract CT 27th Congress of the European-College-of-Neuropsychopharmacology (ECNP) CY OCT 18-21, 2014 CL Berlin, GERMANY SP European Coll Neuropsychopharmacol ID DOUBLE-BLIND; PLACEBO C1 [Thase, M.] Univ Penn, Dept Psychiat, Perelman Sch Med, Philadelphia, PA 19104 USA. [Tsai, J.] Sunovion Pharmaceut Inc, Med Affairs, Marlborough, MA USA. [Kroger, H.; Pikalov, A.; Cucchiaro, J.; Loebel, A.] Sunovion Pharmaceut Inc, Clin Dev & Med Affairs, Ft Lee, VA USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0924-977X EI 1873-7862 J9 EUR NEUROPSYCHOPHARM JI Eur. Neuropsychopharmacol. PD OCT PY 2014 VL 24 SU 2 MA P.2.d.052 BP S444 EP S445 PG 2 WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA CT5LL UT WOS:000362851700199 ER PT J AU Baig, HA Dorman, DB Bulka, BA Shivers, BL Chancey, VC Winkelstein, BA AF Baig, Hassam A. Dorman, Daniel B. Bulka, Ben A. Shivers, Bethany L. Chancey, Valeta C. Winkelstein, Beth A. TI Characterization of the Frequency and Muscle Responses of the Lumbar and Thoracic Spines of Seated Volunteers During Sinusoidal Whole Body Vibration SO JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME LA English DT Article DE vibration; muscle; spine; resonance; electromyography; transmissibility ID MECHANICAL IMPEDANCE; DISCOMFORT; EXPOSURE; MODEL AB Whole body vibration has been postulated to contribute to the onset of back pain. However, little is known about the relationship between vibration exposure, the biomechanical response, and the physiological responses of the seated human. The aim of this study was to measure the frequency and corresponding muscle responses of seated male volunteers during whole body vibration exposures along the vertical and anteroposterior directions to define the transmissibility and associated muscle activation responses for relevant whole body vibration exposures. Seated human male volunteers underwent separate whole body vibration exposures in the vertical (Z-direction) and anteroposterior (X-direction) directions using sinusoidal sweeps ranging from 2 to 18 Hz, with a constant amplitude of 0.4 g. For each vibration exposure, the accelerations and displacements of the seat and lumbar and thoracic spines were recorded. In addition, muscle activity in the lumbar and thoracic spines was recorded using electromyography (EMG) and surface electrodes in the lumbar and thoracic region. Transmissibility was determined, and peak transmissibility, displacement, and muscle activity were compared in each of the lumbar and thoracic regions. The peak transmissibility for vertical vibrations occurred at 4Hz for both the lumbar (1.55 +/- 0.34) and thoracic (1.49 +/- 0.21) regions. For X-directed seat vibrations, the transmissibility ratio in both spinal regions was highest at 2Hz but never exceeded a value of 1. The peak muscle response in both spinal regions occurred at frequencies corresponding to the peak transmissibility, regardless of the direction of imposed seat vibration: 4Hz for the Z-direction and 2-3 Hz for the X-direction. In both vibration directions, spinal displacements occurred primarily in the direction of seat vibration, with little off-axis motion. The occurrence of peak muscle responses at frequencies of peak transmissibility suggests that such frequencies may induce greater muscle activity, leading to muscle fatigue, which could be a contributing mechanism of back pain. C1 [Baig, Hassam A.; Bulka, Ben A.; Winkelstein, Beth A.] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA. [Dorman, Daniel B.; Shivers, Bethany L.] US Army Aeromed Res Lab, Injury Biomech Branch, Oak Ridge Inst Sci & Educ, Ft Rucker, AL 36362 USA. [Chancey, Valeta C.] US Army Aeromed Res Lab, Injury Biomech Branch, Ft Rucker, AL 36362 USA. RP Winkelstein, BA (reprint author), Univ Penn, Dept Bioengn, 210 S 33rd St,Room 240 Skirkanich Hall, Philadelphia, PA 19104 USA. EM winkelst@seas.upenn.edu FU DOD-CDMRP [W81XWH-10-2-0140]; USAARL [USAARL STO F USAARL.IV.ME.2000.04, USAARL ATO R.MRM.2010.06]; U.S. Department of Energy; U.S. Army Medical Research and Materiel Command FX Funding provided by a DOD-CDMRP (W81XWH-10-2-0140) Grant and USAARL (USAARL STO F USAARL.IV.ME.2000.04 and USAARL ATO R.MRM.2010.06).; This research was supported in part by an appointment to the Research Participation Program at the U. S. Army Aeromedical Research Laboratory administered by the Oak Ridge Institute for Science and Education through a Memorandum of Agreement between the U.S. Department of Energy and the U.S. Army Medical Research and Materiel Command. NR 26 TC 5 Z9 5 U1 0 U2 14 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0148-0731 EI 1528-8951 J9 J BIOMECH ENG-T ASME JI J. Biomech. Eng.-Trans. ASME PD OCT PY 2014 VL 136 IS 10 AR 101002 DI 10.1115/1.4027998 PG 7 WC Biophysics; Engineering, Biomedical SC Biophysics; Engineering GA AO4HS UT WOS:000341298400002 PM 25010637 ER PT J AU Banks, DE AF Banks, Daniel E. TI Clinical Aspects of Asbestos-Related Diseases-What Are the Unresolved Topics? SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article; Proceedings Paper CT Conference of American-College-of-Chest-Physicians on Occupational and Environmental Lung Disease 2013 CY JUN 21-23, 2013 CL Toronto, CANADA SP Amer Coll Chest Phys AB Objective: Despite awareness of the health risks associated with asbestos fiber inhalation and the decline in U.S. utilization (about 0.1% of the yearly peak amount), illnesses associated with exposure persist. Those with disease typically describe excessive exposures in the remote past, yet excessive exposures can occur today, most likely related to careless asbestos abatement procedures. The intent is to address unanswered questions associated with asbestos exposure. Methods: The author summarizes clinical information addressing the case definition of asbestosis, the world-wide rate of mesothelioma, and clinical follow-up for those with exposure. Results: The author describes information relevant to issues which remain unresolved. Conclusion: Perhaps somewhat surprisingly, even though there have been a great number of manuscripts reporting on the health risks of asbestos exposure, there remain unanswered questions regarding the pathogenesis of this disease. C1 [Banks, Daniel E.] Uniformed Serv Univ Hlth Sci, Dept Med, Ft Sam Houston, TX USA. [Banks, Daniel E.] Brooke Army Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. RP Banks, DE (reprint author), 2478 Stanley Rd,Suite 103, Ft Sam Houston, TX 78234 USA. EM dbanks49@yahoo.com NR 45 TC 0 Z9 1 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1076-2752 EI 1536-5948 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD OCT PY 2014 VL 56 IS 10 SU S BP S8 EP S12 DI 10.1097/JOM.0000000000000242 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA V44HZ UT WOS:000209741400003 PM 25285978 ER PT J AU Banks, DE AF Banks, Daniel E. TI Introduction to the Supplement Clinical Aspects of Occupational and Environmental Lung Disease SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Editorial Material C1 [Banks, Daniel E.] Uniformed Serv Univ Hlth Sci, Dept Med, Houston, TX USA. RP Banks, DE (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med, Brooke Army Med Ctr, 2478 Stanley Rd,Suite 103, Ft Sam Houston, TX 78234 USA. EM Daniel.E.Banks3.mil@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1076-2752 EI 1536-5948 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD OCT PY 2014 VL 56 IS 10 SU S BP S1 EP S2 DI 10.1097/JOM.0000000000000291 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA V44HZ UT WOS:000209741400001 PM 25285968 ER PT J AU Morrison, JJ Ross, JD Markov, NP Scott, DJ Spencer, JR Rasmussen, TE AF Morrison, Jonathan J. Ross, James D. Markov, Nickolay P. Scott, Daniel J. Spencer, Jerry R. Rasmussen, Todd E. TI The inflammatory sequelae of aortic balloon occlusion in hemorrhagic shock SO JOURNAL OF SURGICAL RESEARCH LA English DT Article DE Resuscitative endovascular balloon occlusion of the aorta; REBOA; Noncompressible torso hemorrhage; Hemorrhagic shock; Resuscitation ID NONCOMPRESSIBLE TORSO HEMORRHAGE; RESPIRATORY-DISTRESS-SYNDROME; TUMOR-NECROSIS-FACTOR; UK COMBAT CASUALTIES; PORCINE MODEL; TRAUMA CENTER; INJURY; INTERLEUKIN-6; MORTALITY; DEATHS AB Background: Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a hemorrhage control and resuscitative adjunct that has been demonstrated to improve central perfusion during hemorrhagic shock. The aim of this study was to characterize the systemic inflammatory response associated and cardiopulmonary sequelae with 30, 60, and 90 min of balloon occlusion and shock on the release of interleukin 6 (IL-6) and tumor necrosis factor alpha. Materials and methods: Anesthetized female Yorkshire swine (Sus scrofa, weight 70-90 kg) underwent a 35% blood volume-controlled hemorrhage followed by thoracic aortic balloon occlusion of 30 (30-REBOA, n = 6), 60 (60-REBOA, n = 8), and 90 min (90-REBOA, n = 6). This was followed by resuscitation with whole blood and crystalloid over 6 h. Animals then underwent 48 h of critical care with sedation, fluid, and vasopressor support. Results: All animals were successfully induced into hemorrhagic shock without mortality. All groups responded to aortic occlusion with a rise in blood pressure above baseline values. IL-6, as measured (picogram per milliliter) at 8h, was significantly elevated from baseline values in the 60-REBOA and 90-REBOA groups: 289 +/- 258 versus 10 +/- 5; P = 0.018 and 630 +/- 348; P = 0.007, respectively. There was a trend toward greater vasopressor use (P = 0.183) and increased incidence of acute respiratory distress syndrome (P = 0.052) across the groups. Conclusions: REBOA is a useful adjunct in supporting central perfusion during hemorrhagic shock; however, increasing occlusion time and shock results in a greater IL-6 release. Clinicians must anticipate inflammation-mediated organ failure in post-REBOA use patients. Published by Elsevier Inc. C1 [Morrison, Jonathan J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. [Morrison, Jonathan J.; Markov, Nickolay P.; Scott, Daniel J.; Rasmussen, Todd E.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Morrison, Jonathan J.] Glasgow Royal Infirm, Acad Surg Unit, Glasgow G4 0SF, Lanark, Scotland. [Ross, James D.; Scott, Daniel J.; Spencer, Jerry R.; Rasmussen, Todd E.] Joint Base San Antonio, Med Wing 59, Lackland AFB, TX USA. [Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. RP Rasmussen, TE (reprint author), US Combat Casualty Care Res Program, 722 Doughten St,Room 3, Ft Detrick, MD 21702 USA. EM todd.e.rasmussen.mil@mail.mil OI Morrison, Jonathan/0000-0001-7462-8456 NR 37 TC 12 Z9 12 U1 0 U2 4 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-4804 EI 1095-8673 J9 J SURG RES JI J. Surg. Res. PD OCT PY 2014 VL 191 IS 2 BP 423 EP 431 DI 10.1016/j.jss.2014.04.012 PG 9 WC Surgery SC Surgery GA AO5CB UT WOS:000341358100023 PM 24836421 ER PT J AU Mayo, M Collier, ZA Hoang, V Chappell, M AF Mayo, Michael Collier, Zachary A. Vu Hoang Chappell, Mark TI Uncertainty in multi-media fate and transport models: A case study for TNT life cycle assessment SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Uncertainty; Sensitivity analysis; Life cycle assessment; Fate and transport model; SimpleBox; Trinitrotoluene ID MULTICRITERIA DECISION-ANALYSIS; SUBSTANCES; ENTHALPIES; SIMULATION; CHEMICALS; PARADIGM; EXPOSURE; WATER; LCA AB Life cycle assessment (LCA) is an evaluation method used by decision-makers to help assess the relative environmental impacts of various industrial processes. Despite that many LCA methods remain sensitive to uncertain input data, which can reduce the utility of their results, uncertainty arising from constituent LCA models remains poorly understood. Here, we begin to address this problem by evaluating the extent to which parameter-value uncertainty affects the SimpleBox 2.0 fate and transport model, which serves as a backbone for many LCA ecotoxicological impact categories. Two Monte Carlo type sampling methods were used to evaluate dispersion in steady-state concentration values for three chemicals involved in grenade production: toluene, 2,4-dinitrotoluene (2,4-DNT), and 2,4,6-trinitrotoluene (TNT). Parameters were first sampled stochastically one-at-a-time, then by randomly exploring a local patch of the parameter space. We confirmed that global temperatures contribute primarily to the overall variance of model results, which at most spanned approximately 8 decades in magnitude. These results are consistent with previous results obtained for the whole of the LCA method. LCA methods carry out calculations iteratively; a reduction in the error of a single component, such as the fate and transport model, may therefore improve its performance and utility as a decision-making aid. Published by Elsevier B.V. C1 [Mayo, Michael; Collier, Zachary A.; Chappell, Mark] US Army, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. [Vu Hoang] Michigan State Univ, Dept Biosyst Engn, E Lansing, MI 48824 USA. RP Chappell, M (reprint author), 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Mark.A.Chappell@erdc.dren.mil FU Military Materials in the Environment (MME) Program for the US Army Engineer Research & Development (ERDC) Laboratory FX Permission was granted by the USACE Chief of Engineers to publish this material. The views and opinions expressed in this paper are those of the individual authors and not those of the US Army, or other sponsor organizations. This work was funded through the Military Materials in the Environment (MME) Program for the US Army Engineer Research & Development (ERDC) Laboratory. NR 50 TC 4 Z9 4 U1 1 U2 17 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 EI 1879-1026 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD OCT 1 PY 2014 VL 494 BP 104 EP 112 DI 10.1016/j.scitotenv.2014.06.061 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA AO4VR UT WOS:000341340000012 PM 25037048 ER PT J AU Russell, AL Seiter, JM Coleman, JG Winstead, B Bednar, AJ AF Russell, A. L. Seiter, J. M. Coleman, J. G. Winstead, B. Bednar, A. J. TI Analysis of munitions constituents in IMX formulations by HPLC and HPLC-MS SO TALANTA LA English DT Article DE Insensitive munitions; HPLC; HPLC-MS; Munitions constituents analysis ID PERFORMANCE LIQUID-CHROMATOGRAPHY; EXPLOSIVES; SEPARATION; NTO AB The use of Insensitive Munitions explosives (IMX) is increasing as the Army seeks to replace certain conventional munitions constituents, such as 2,4,6-trinitrotolene (TNT), for improved safety. The IMX formulations are more stable and therefore less prone to accidental detonation while designed to match the performance of legacy materials. Two formulations, IMX 101 and 104 are being investigated as a replacement for TNT in artillery rounds and composition B Army mortars, respectively. The chemical formulations of IMX-101 and 104 are comprised of four constituents;2,4-dinitroanisole (DNAN), 3-nitro-1,2,4-triazol-5-one (NTO), 1-nitroguanidine (NQ), and Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) which are mixed in various ratios to achieve the desired performance. The current work details the analysis of the IMX constituents by single column HPLC-UV-ESI-MS. Detection limits determined are in agreement with similar HPLC analysis of compounds, ranging from 7 to 9 mu g/L. Gradient mobile phases are used to allow separation of the 4 target compounds in more complex mixture of other concomitant compounds. Mass spectra are used to confirm analyte identity with chromatographic retention time. Published by Elsevier B.V. C1 [Russell, A. L.] Badger Tech Serv, Vicksburg, MS 39180 USA. [Seiter, J. M.; Coleman, J. G.; Bednar, A. J.] US Army, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Winstead, B.] BAE Syst Ordnance Syst INC, Kingsport, TN 37660 USA. RP Bednar, AJ (reprint author), US Army, Engn Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Anthony.J.Bednar@usace.army.mil NR 16 TC 7 Z9 7 U1 2 U2 39 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0039-9140 EI 1873-3573 J9 TALANTA JI Talanta PD OCT 1 PY 2014 VL 128 BP 524 EP 530 DI 10.1016/j.talanta.2014.02.013 PG 7 WC Chemistry, Analytical SC Chemistry GA AN6FE UT WOS:000340689500075 PM 25059196 ER PT J AU Wierzbicki, TA Lee, IC Gupta, AK AF Wierzbicki, Teresa A. Lee, Ivan C. Gupta, Ashwani K. TI Combustion of propane with Pt and Rh catalysts in a meso-scale heat recirculating combustor SO APPLIED ENERGY LA English DT Article; Proceedings Paper CT 5th International Conference on Applied Energy (ICAE) CY JUL 01-04, 2013 CL Pretoria, SOUTH AFRICA DE Catalytic combustion; Heat-recirculating combustor; Meso-scale combustion; Propane oxidation; Combustion behavior ID JET FUELS; PERFORMANCE; MICROCHANNELS; SIMULATIONS; GENERATION; SYSTEM; STEP AB The results obtained from the combustion behavior of propane over platinum and rhodium catalysts in a meso-scale heat recirculating combustor are presented. The extinction limits, conversion, product selectivity/yield, and activation energy using the two catalysts were compared in an effort to predict their performance using a liquid fuel. The extinction limits were also compared to those of non-catalytic combustion in the same combustor. The results showed that the use of a catalyst greatly expanded the range of stable operating conditions, in terms of both extinction limits and flow rates supported. The Rh catalyst was found to exhibit a higher propane conversion rate, reaching a maximum of 90.4% at stoichiometric conditions (as compared to only 61.4% offered by the Pt catalyst under lean conditions), but the Pt catalyst had superior CO2 selectivity for most of the examined conditions, indicating more of the heat released being used for product formation as opposed to being lost to the environment.-However, despite having a higher rate of heat loss, the combustion with the Rh catalyst produced an overall higher amount of enthalpy than the Pt due to its superior fuel conversion. The Pt catalyst also had a significantly smaller activation energy (13.8 kJ/mol) than the Rh catalyst (74.7 kJ/mol), except at equivalence ratios richer than Phi = 1.75 (corresponding to catalyst temperatures below 500 degrees C), where it abruptly changed to 211.4 kJ/mol, signifying a transition from diffusion-limited reactions to kinetically limited reactions at this point. The results reveal that Rh would be a more suitable catalyst for use in liquid-fueled meso-scale combustors, as fuel conversion has been found to be a limiting factor for combustion stability in these systems, and as its higher output energy allows for greater flexibility of use. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Wierzbicki, Teresa A.; Gupta, Ashwani K.] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. [Wierzbicki, Teresa A.; Lee, Ivan C.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Gupta, AK (reprint author), Univ Maryland, Dept Mech Engn, 2181 Martin Hall,Campus Dr, College Pk, MD 20742 USA. EM twierz@umd.edu; ivan.c.lee2.civ@mail.mil; akgupta@umd.edu NR 28 TC 23 Z9 23 U1 1 U2 16 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0306-2619 EI 1872-9118 J9 APPL ENERG JI Appl. Energy PD OCT 1 PY 2014 VL 130 SI SI BP 350 EP 356 DI 10.1016/j.apenergy.2014.05.069 PN 1 PG 7 WC Energy & Fuels; Engineering, Chemical SC Energy & Fuels; Engineering GA AN0ZC UT WOS:000340311500035 ER PT J AU Mishchenko, MI Zakharova, NT Khlebtsov, NG Wriedt, T Videen, G AF Mishchenko, Michael I. Zakharova, Nadezhda T. Khlebtsov, Nikolai G. Wriedt, Thomas Videen, Gorden TI Comprehensive thematic T-matrix reference database: A 2013-2014 update SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article DE Electromagnetic scattering; T-matrix method; Complex scattering objects ID DEPOLARIZED LIGHT-SCATTERING; POLAR STRATOSPHERIC CLOUDS; PARTICLE NON-SPHERICITY; X-BAND RADAR; OPTICAL-PROPERTIES; SINGLE-SCATTERING; MICROWAVE LINKS; ELECTROMAGNETIC SCATTERING; COHERENT BACKSCATTERING; HETEROGENEOUS FORMATION AB This paper is the sixth update to the comprehensive thematic database of peer-reviewed T-matrix publications initiated by us in 2004 and includes relevant publications that have appeared since 2013. It also lists several earlier publications not incorporated in the original database and previous updates. Published by Elsevier Ltd. C1 [Mishchenko, Michael I.] NASA, Goddard Inst Space Studies, New York, NY 10025 USA. [Zakharova, Nadezhda T.] Trinnovim LLC, New York, NY 10025 USA. [Khlebtsov, Nikolai G.] Russian Acad Sci, Inst Biochem & Physiol Plants & Microorganisms, Saratov 410015, Russia. [Wriedt, Thomas] Inst Werkstofftech, D-28359 Bremen, Germany. [Videen, Gorden] US Army, Res Lab, AMSRL IS EE, Adelphi, MD 20783 USA. RP Mishchenko, MI (reprint author), NASA, Goddard Inst Space Studies, 2880 Broadway, New York, NY 10025 USA. EM crmim2@gmail.com RI Mishchenko, Michael/D-4426-2012; Khlebtsov, Nikolai/D-6199-2017; OI Khlebtsov, Nikolai/0000-0002-2055-7784 FU NASA Radiation Sciences Program; NASA Remote Sensing Theory Program; RFBR; Russian Scientific Foundation FX We thank Josefina Mora and Zoe Wai for helping to obtain copies of publications that were not readily accessible. MIM was supported by the NASA Radiation Sciences Program managed by Hal Maring and by the NASA Remote Sensing Theory Program managed by Lucia Tsaoussi. NGK was supported by grants from RFBR and Russian Scientific Foundation. NR 158 TC 21 Z9 22 U1 3 U2 38 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 EI 1879-1352 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD OCT PY 2014 VL 146 SI SI BP 349 EP 354 DI 10.1016/j.jqsrt.2014.03.022 PG 6 WC Optics; Spectroscopy SC Optics; Spectroscopy GA AM2RA UT WOS:000339697300031 ER PT J AU Wilkman, O Muinonen, K Videen, G Josset, JL Souchon, A AF Wilkman, O. Muinonen, K. Videen, G. Josset, J. -L. Souchon, A. CA SMART-1 AMIE Team TI Lunar photometric modelling with SMART-1/AMIE imaging data SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article DE Moon; Opposition effect; Photometry; Coherent backscattering; Shadowing; Radiative transfer ID PARTICULATE MEDIA; SURFACE AB We investigate the light-scattering properties of the lunar mare areas. A large photometric dataset was extracted from images taken by the AMIE camera on board the SMART-1 spacecraft. Inter-particle shadowing effects in the regolith are modelled using ray-tracing simulations, and then a phase function is fit to the data using Bayesian techniques and Markov chain Monte Carlo. Additionally, the data are fit with phase functions computed from radiative-transfer coherent-backscatter (RT-CB) simulations. The results indicate that the lunar photometry, including both the opposition effect and azimuthal effects, can be explained well with a combination of inter-particle shadowing and coherent backscattering. Our results produce loose constraints on the mare physical properties. The RT-CB results indicate that the scattering volume element is optically thick. In both the Bayesian analysis and the RT-CB fit, models with lower packing density and/or higher surface roughness always produce better fits to the data than densely packed, smoother ones. (C) 2014 Published by Elsevier Ltd. C1 [Wilkman, O.; Muinonen, K.] Univ Helsinki, Dept Phys, FI-00014 Helsinki, Finland. [Muinonen, K.] Finnish Geodet Inst, FI-02431 Masala, Finland. [Videen, G.] Army Res Lab AMSRL CI EM, Adelphi, MD 20783 USA. [Videen, G.] Space Sci Inst, Boulder, CO 80301 USA. [Josset, J. -L.; Souchon, A.] Space Explorat Inst, CH-2002 Neuchatel, Switzerland. RP Wilkman, O (reprint author), Univ Helsinki, Dept Phys, POB 64, FI-00014 Helsinki, Finland. EM olli.wilkman@helsinki.fi FU Academy of Finland [257966]; NASA Outer Planets Research Program [NNX10AP93G]; NASA Lunar Advanced Science and Exploration Research Program [NNX11AB25G] FX Research supported, in part, by the Academy of Finland (Grant No. 257966), and by the NASA Outer Planets Research Program (contract NNX10AP93G), and NASA Lunar Advanced Science and Exploration Research Program (contract NNX11AB25G). We are grateful to Kari Lumme, Jouni Peltoniemi, and two anonymous reviewers for their valuable comments that helped us improve the manuscript. NR 31 TC 2 Z9 2 U1 0 U2 13 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 EI 1879-1352 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD OCT PY 2014 VL 146 SI SI BP 529 EP 539 DI 10.1016/j.jqsrt.2014.01.015 PG 11 WC Optics; Spectroscopy SC Optics; Spectroscopy GA AM2RA UT WOS:000339697300050 ER PT J AU Mathaudhu, SN Estrin, Y Horita, Z Lavernia, E Liao, XZ Lu, L Wei, QM Wilde, G Zhu, YT AF Mathaudhu, Suveen N. Estrin, Yuri Horita, Zenji Lavernia, Enrique Liao, Xiao Zhou Lu, Lei Wei, Qiuming Wilde, Gerhard Zhu, Yun Tian TI Preface to the special issue on ultrafine-grained materials SO JOURNAL OF MATERIALS SCIENCE LA English DT Editorial Material C1 [Mathaudhu, Suveen N.] US Army, Res Off, Res Triangle Pk, NC 27709 USA. [Estrin, Yuri] Monash Univ, Clayton, Vic, Australia. [Horita, Zenji] Kyushu Univ, Fukuoka 812, Japan. [Lavernia, Enrique] Univ Calif Davis, Davis, CA 95616 USA. [Liao, Xiao Zhou] Univ Sydney, Sydney, NSW 2006, Australia. [Lu, Lei] Acad Sinica, Inst Met Res, Shenyang 110015, Peoples R China. [Wei, Qiuming] Univ N Carolina, Charlotte, NC 28223 USA. [Wilde, Gerhard] Univ Munster, D-48149 Munster, Germany. [Zhu, Yun Tian] N Carolina State Univ, Raleigh, NC 27695 USA. RP Zhu, YT (reprint author), N Carolina State Univ, Raleigh, NC 27695 USA. EM suveen.n.mathaudhu.civ@mail.mil; yuri.estrin@monash.edu; horita@zaiko.kyushu-u.ac.jp; lavernia@ucdavis.edu; xiaozhou.liao@sydney.edu.au; llu@imr.ac.cn; qwei@uncc.edu; gwilde@uni-muenster.de; ytzhu@ncsu.edu RI Wei, Qiuming/B-7579-2008; Liao, Xiaozhou/B-3168-2009; Wilde, Gerhard/C-7808-2013; Mathaudhu, Suveen/B-4192-2009; Zhu, Yuntian/B-3021-2008; OI Liao, Xiaozhou/0000-0001-8565-1758; Zhu, Yuntian/0000-0002-5961-7422; Wilde, Gerhard/0000-0001-8001-5998 NR 0 TC 2 Z9 2 U1 1 U2 21 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 EI 1573-4803 J9 J MATER SCI JI J. Mater. Sci. PD OCT PY 2014 VL 49 IS 19 BP 6485 EP 6486 DI 10.1007/s10853-014-8393-y PG 2 WC Materials Science, Multidisciplinary SC Materials Science GA AL7TE UT WOS:000339337600001 ER PT J AU Dong, L Namburu, RR O'Regan, TP Dubey, M Dongare, AM AF Dong, Liang Namburu, Raju R. O'Regan, Terrance P. Dubey, Madan Dongare, Avinash M. TI Theoretical study on strain-induced variations in electronic properties of monolayer MoS2 SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID TRANSITION-METAL DICHALCOGENIDES; DENSITY-FUNCTIONAL THEORY; SINGLE-LAYER MOS2; MAGNETIC-PROPERTIES; NANORIBBONS; GRAPHENE; BILAYER; FILMS; GAP AB Ultrathin MoS2 sheets and nanostructures are promising materials for electronic and optoelectronic devices as well as chemical catalysts. To expand their potential in applications, a fundamental understanding is needed of the electronic structure and carrier mobility as a function of strain. In this paper, the effect of strain on electronic properties of monolayer MoS2 is investigated using ab initio simulations based on density functional theory. Our calculations are performed in both infinitely large two-dimensional (2D) sheets and one-dimensional (1D) nanoribbons which are theoretically cut from the sheets with semiconducting (armchair) edges. The 2D crystal is studied under biaxial strain, uniaxial strain, and uniaxial stress conditions, while the 1D nanoribbon is studied under a uniaxial stress condition. Our results suggest that the electronic bandgap of the 2D sheet experiences a direct-indirect transition under both tensile and compressive strains. Its bandgap energy (E (g)) decreases under tensile strain/stress conditions, while for an in-plane compression, E (g) is initially raised by a small amount and then decreased as the strain varies from 0 to -6 %. On the other hand, E (g) at the semiconducting edges of monolayer MoS2 nanoribbons is relatively invariant under uniaxial stretches or compressions. The effective masses of electrons at the conduction band minimum (CBM) and holes at the valence band maximum (VBM) are generally decreased as the in-plane extensions or compressions become stronger, but abrupt changes occur when CBM or VBM shifts between different k-points in the first Brillouin zone. C1 [Dong, Liang; Dongare, Avinash M.] Univ Connecticut, Dept Mat Sci & Engn, Storrs, CT 06269 USA. [Dong, Liang; Dongare, Avinash M.] Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA. [Namburu, Raju R.] US Army Res Lab, Computat & Informat Sci Directorate, Aberdeen Proving Ground, MD 21005 USA. [O'Regan, Terrance P.; Dubey, Madan] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Dongare, AM (reprint author), Univ Connecticut, Dept Mat Sci & Engn, Storrs, CT 06269 USA. EM dongare@uconn.edu RI Dong, Liang/O-3439-2015; OI Dongare, Avinash/0000-0003-3189-3588; Dong, Liang/0000-0002-3916-1720 FU U.S. Department of Energy; ASARL; US Army Research Laboratory (ARL) Director's Strategic Initiative (DSI) FX This research was supported in part by an appointment of A. M. Dongare to the Faculty Research Participation Program at the U. S. Army Research Laboratory (USARL) administered by the Oak Ridge Institute for Science and Education through an interagency between the U.S. Department of Energy and ASARL. The authors R. R. Namburu, T. P. O'Regan, and M. Dubey acknowledge the support of the US Army Research Laboratory (ARL) Director's Strategic Initiative (DSI) program on interfaces in stacked 2D atomic layered materials. NR 40 TC 15 Z9 15 U1 13 U2 214 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 EI 1573-4803 J9 J MATER SCI JI J. Mater. Sci. PD OCT PY 2014 VL 49 IS 19 BP 6762 EP 6771 DI 10.1007/s10853-014-8370-5 PG 10 WC Materials Science, Multidisciplinary SC Materials Science GA AL7TE UT WOS:000339337600032 ER PT J AU Wijayalath, W Majji, S Villasante, EF Brumeanu, TD Richie, TL Casares, S AF Wijayalath, Wathsala Majji, Sai Villasante, Eileen F. Brumeanu, Teodor D. Richie, Thomas L. Casares, Sofia TI Humanized HLA-DR4.RagKO.IL2R gamma cKO.NOD (DRAG) mice sustain the complex vertebrate life cycle of Plasmodium falciparum malaria SO MALARIA JOURNAL LA English DT Article DE Malaria; Plasmodium falciparum; Human-immune-system humanized mice; Hepatocytes; Kupffer cells; Liver endothelial cells; Erythrocytes; Antibodies; Cellular-mediated immunity ID LIVER-STAGE DEVELOPMENT; RED-BLOOD-CELLS; IMMUNE-RESPONSES; MOUSE MODEL; PARASITES; HEPATOCYTES; SPOROZOITE; PROTECTION; INFECTION; ASSAY AB Background: Malaria is a deadly infectious disease affecting millions of people in tropical and sub-tropical countries. Among the five species of Plasmodium parasites that infect humans, Plasmodium falciparum accounts for the highest morbidity and mortality associated with malaria. Since humans are the only natural hosts for P. falciparum, the lack of convenient animal models has hindered the understanding of disease pathogenesis and prompted the need of testing anti-malarial drugs and vaccines directly in human trials. Humanized mice hosting human cells represent new pre-clinical models for infectious diseases that affect only humans. In this study, the ability of human-immune-system humanized HLA-DR4.RagKO.IL2R gamma cKO.NOD (DRAG) mice to sustain infection with P. falciparum was explored. Methods: Four week-old DRAG mice were infused with HLA-matched human haematopoietic stem cells (HSC) and examined for reconstitution of human liver cells and erythrocytes. Upon challenge with infectious P. falciparum sporozoites (NF54 strain) humanized DRAG mice were examined for liver stage infection, blood stage infection, and transmission to Anopheles stephensi mosquitoes. Results: Humanized DRAG mice reconstituted human hepatocytes, Kupffer cells, liver endothelial cells, and erythrocytes. Upon intravenous challenge with P. falciparum sporozoites, DRAG mice sustained liver to blood stage infection (average 3-5 parasites/microlitre blood) and allowed transmission to An. stephensi mosquitoes. Infected DRAG mice elicited antibody and cellular responses to the blood stage parasites and self-cured the infection by day 45 post-challenge. Conclusions: DRAG mice represent the first human-immune-system humanized mouse model that sustains the complex vertebrate life cycle of P. falciparum without the need of exogenous injection of human hepatocytes/erythrocytes or P. falciparum parasite adaptation. The ability of DRAG mice to elicit specific human immune responses to P. falciparum parasites may help deciphering immune correlates of protection and to identify protective malaria antigens. C1 [Wijayalath, Wathsala; Majji, Sai; Villasante, Eileen F.; Richie, Thomas L.; Casares, Sofia] Naval Med Res Ctr, Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Silver Spring, MD 20910 USA. [Richie, Thomas L.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. RP Casares, S (reprint author), Sanaria Inc, 9800 Med Ctr Dr, Rockville, MD 20850 USA. EM sofia.a.casares.civ@mail.mil OI Richie, Thomas/0000-0002-2946-5456 FU Military Infectious Diseases Research Program (MIDRP) [6000.RAD1.F]; U.S. Agency for International Development (USAID) FX The authors would like to thank Megan Dowler for providing P. falciparum-infected mosquitoes, to Ms. Sandra Inoue for animal care and technical assistance, and to Dr. Urszula Krzych for helpful discussions. This work was supported by work unit number 6000.RAD1.F under grants from the Military Infectious Diseases Research Program (MIDRP) and the U.S. Agency for International Development (USAID) to SC. SC, TDB, and EFV are US Government employees and TLR was a military service member at the time of this study. The work of these individuals was prepared as part of official government duties. Title 17 U. S. C. 105 provides that 'Copyright protection under this title is not available for any work of the United States Government.' Title 17 U. S. C. 101 defines a U. S. Government work as a work prepared by a military service member or employee of the U. S. Government as part of that person's official duties. The views expressed are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, nor the U. S. Government. NR 49 TC 10 Z9 10 U1 0 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD SEP 30 PY 2014 VL 13 AR 386 DI 10.1186/1475-2875-13-386 PG 14 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AS2OD UT WOS:000344118600001 PM 25266106 ER PT J AU Lemasson, BH Haefner, JW Bowen, MD AF Lemasson, Bertrand H. Haefner, James W. Bowen, Mark D. TI Schooling Increases Risk Exposure for Fish Navigating Past Artificial Barriers SO PLOS ONE LA English DT Article ID ATLANTIC SALMON; CLOSE ENCOUNTERS; WATER DIVERSION; 2-VECTOR FLOWS; PREDATION RISK; CHINOOK SALMON; ANIMAL GROUPS; BEHAVIOR; PASSAGE; MOVEMENT AB Artificial barriers have become ubiquitous features in freshwater ecosystems and they can significantly impact a region's biodiversity. Assessing the risk faced by fish forced to navigate their way around artificial barriers is largely based on assays of individual swimming behavior. However, social interactions can significantly influence fish movement patterns and alter their risk exposure. Using an experimental flume, we assessed the effects of social interactions on the amount of time required for juvenile palmetto bass (Morone chrysops x M. saxatilis) to navigate downstream past an artificial barrier. Fish were released either individually or in groups into the flume using flow conditions that approached the limit of their expected swimming stamina. We compared fish swimming behaviors under solitary and schooling conditions and measured risk as the time individuals spent exposed to the barrier. Solitary fish generally turned with the current and moved quickly downstream past the barrier, while fish in groups swam against the current and displayed a 23-fold increase in exposure time. Solitary individuals also showed greater signs of skittish behavior than those released in groups, which was reflected by larger changes in their accelerations and turning profiles. While groups displayed fission-fusion dynamics, interindividual positions were highly structured and remained steady over time. These spatial patterns align with theoretical positions necessary to reduce swimming exertion through either wake capturing or velocity sheltering, but diverge from any potential gains from channeling effects between adjacent neighbors. We conclude that isolated performance trials and projections based on individual behaviors can lead to erroneous predictions of risk exposure along engineered structures. Our results also suggest that risk perception and behavior may be more important than a fish's swimming stamina in artificially modified systems. C1 [Lemasson, Bertrand H.; Haefner, James W.] Utah State Univ, Dept Biol, Logan, UT 84322 USA. [Lemasson, Bertrand H.; Haefner, James W.] Utah State Univ, Ctr Ecol, Logan, UT 84322 USA. [Bowen, Mark D.] US Bur Reclamat, Fisheries & Wildlife Resources Grp, Denver, CO 80225 USA. RP Lemasson, BH (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, Santa Barbara, CA USA. EM brilraven@gmail.com FU Bureau of Reclamation's Tracy Fish Improvement Program [FC810748]; U.S. Army Engineer Research & Development Center's basic research program in network sciences [BT25/NS/14-63] FX Funding for this work was provided by the Bureau of Reclamation's Tracy Fish Improvement Program (No. FC810748) and the U.S. Army Engineer Research & Development Center's basic research program in network sciences (BT25/NS/14-63). Dr. Mark Bowen, a co-author on this study, is a former employee of this institution and contributed to the design of the experiment. Mark did not participate in data collection and analyses, nor was he involved in the decision to publish the findings. While Mark did not write the manuscript, he has commented on the final product. NR 56 TC 0 Z9 0 U1 3 U2 11 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD SEP 30 PY 2014 VL 9 IS 9 AR e108220 DI 10.1371/journal.pone.0108220 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AR6CW UT WOS:000343671700073 PM 25268736 ER PT J AU Satapathi, S Gill, HS Das, S Li, L Samuelson, L Green, MJ Kumar, J AF Satapathi, Soumitra Gill, Hardeep Singh Das, Sriya Li, Lian Samuelson, Lynne Green, Micah J. Kumar, Jayant TI Performance enhancement of dye-sensitized solar cells by incorporating graphene sheets of various sizes SO APPLIED SURFACE SCIENCE LA English DT Article DE Graphene; Dye sensitized solar cells; Dye-Loading; Porosity ID ELECTRODE; COMPOSITES; EFFICIENCY AB Dye-sensitized solar cells (DSSCs) were fabricated using photoanodes made from graphene-TiO2 nanocomposites. The dependence of the size of graphene sheets on the cell performance was investigated. The experimental results indicated that cells loaded with the smaller graphene sheets yielded larger enhancement. The smaller graphene sheets improved the dye adsorption, leading to higher conversion efficiency. The DSSC incorporated with graphene sheets of 184 nm exhibited the largest enhancement in efficiency (similar to 49%) as compared to the cell without graphene. (C) 2014 Elsevier B.V. All rights reserved. C1 [Satapathi, Soumitra; Gill, Hardeep Singh; Kumar, Jayant] Univ Massachusetts Lowell, Ctr Adv Mat, Lowell, MA 01854 USA. [Das, Sriya; Green, Micah J.] Texas Tech Univ, Dept Chem Engn, Lubbock, TX 79409 USA. [Li, Lian; Samuelson, Lynne] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. RP Kumar, J (reprint author), Univ Massachusetts Lowell, Ctr Adv Mat, Lowell, MA 01854 USA. EM hardeep_gill@student.uml.edu; Jayant_kumar@uml.edu RI Green, Micah/C-7647-2011 OI Green, Micah/0000-0001-5691-0861 FU Polymer-Based Materials for Harvesting Solar Energy, an Energy Frontier Research Center - U.S. Department of Energy, Office of Science, Basic Energy Sciences [DE-SC0001087]; U.S. Department of Energy; NSRDEC; U.S. NSF [CMMI-1200489] FX This work was supported as part of Polymer-Based Materials for Harvesting Solar Energy, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Basic Energy Sciences under Award #DE-SC0001087.This research was also supported by in part by an appointment to the Faculty Research Participation Program at the U.S. Army Natick Soldier Research, Development and Engineering Center (NSRDEC) administered by the Oak Ridge Institute for Science and Education through and interagency agreement between the U.S. Department of Energy and NSRDEC. Contributions from MJG & SD were supported by the U.S. NSF under award CMMI-1200489. NR 19 TC 16 Z9 16 U1 0 U2 32 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-4332 EI 1873-5584 J9 APPL SURF SCI JI Appl. Surf. Sci. PD SEP 30 PY 2014 VL 314 BP 638 EP 641 DI 10.1016/j.apsusc.2014.07.003 PG 4 WC Chemistry, Physical; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter SC Chemistry; Materials Science; Physics GA AO6LR UT WOS:000341464100090 ER PT J AU Tassaneetrithep, B Tivon, D Swetnam, J Karasavvas, N Michael, NL Kim, JH Marovich, M Cardozo, T AF Tassaneetrithep, Boonrat Tivon, Doreen Swetnam, James Karasavvas, Nicos Michael, Nelson L. Kim, Jerome H. Marovich, Mary Cardozo, Timothy TI Cryptic Determinant of alpha 4 beta 7 Binding in the V2 Loop of HIV-1 gp120 SO PLOS ONE LA English DT Article ID VACCINE EFFICACY; T-CELLS; INFECTION; REGIONS; ANTIBODIES; INTEGRIN; TRIAL AB The peptide segment of the second variable loop of HIV-1 spanning positions 166-181 harbors two functionally important sites. The first, spanning positions 179-181, engages the human alpha 4 beta 7 integrin receptor which is involved in T-cell guthoming and may play a role in human immunodeficiency virus (HIV)-host cell interactions. The second, at positions 166-178, is a major target of anti-V2 antibodies elicited by the ALVAC/AIDSVAX vaccine used in the RV144 clinical trial. Notably, these two sites are directly adjacent, but do not overlap. Here, we report the identity of a second determinant of alpha 4 beta 7 binding located at positions 170-172 of the V2 loop. This segment - tripeptide QRV(170-172)-is located within the second site, yet functionally affects the first site. The absence of this segment abrogates alpha 4 beta 7 binding in peptides bearing the same sequence from position 173-185 as the V2 loops of the RV144 vaccines. However, peptides exhibiting V2 loop sequences from heterologous HIV-1 strains that include this QRV(170-172) motif bind the alpha 4 beta 7 receptor on cells. Therefore, the peptide segment at positions 166-178 of the V2 loop of HIV-1 viruses appears to harbor a cryptic determinant of alpha 4 beta 7 binding. Prior studies show that the anti-V2 antibody response elicited by the RV144 vaccine, along with immune pressure inferred from a sieve analysis, is directed to this same region of the V2 loop. Accordingly, the anti-V2 antibodies that apparently reduced the risk of infection in the RV144 trial may have functioned by blocking alpha 4 beta 7-mediated HIV-host cell interactions via this cryptic determinant. C1 [Tassaneetrithep, Boonrat] Mahidol Univ, Fac Med, Siriraj Hosp, Off Res & Dev, Bangkok 10700, Thailand. [Tassaneetrithep, Boonrat; Michael, Nelson L.; Kim, Jerome H.; Marovich, Mary] Walter Reed Army Inst Res, US Mil Hlth Res Program, Silver Spring, MD USA. [Tivon, Doreen; Swetnam, James; Cardozo, Timothy] NYU, Sch Med, Dept Biochem & Mol Pharmacol, New York, NY 10012 USA. [Karasavvas, Nicos] Armed Forces Res Inst Med Sci, US Army Med Component, Dept Retrovirol, Bangkok 10400, Thailand. RP Cardozo, T (reprint author), NYU, Sch Med, Dept Biochem & Mol Pharmacol, New York, NY 10012 USA. EM Timothy.Cardozo@nyumc.org FU National Institutes of Health [R01A1084119]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-11-2-0174]; U.S. Department of Defense (DOD) [W81XWH-11-2-0174] FX This work was supported by a grant from the National Institutes of Health R01A1084119 to Timothy Cardozo, and a cooperative agreement (W81XWH-11-2-0174) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 21 TC 5 Z9 5 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD SEP 29 PY 2014 VL 9 IS 9 AR e108446 DI 10.1371/journal.pone.0108446 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AU6XR UT WOS:000345745400076 PM 25265384 ER PT J AU Kumar, P Malinovskaya, SA Malinovsky, VS AF Kumar, Praveen Malinovskaya, Svetlana A. Malinovsky, Vladimir S. TI Optimal control of multilevel quantum systems in the field-interaction representation SO PHYSICAL REVIEW A LA English DT Article ID POPULATION TRANSFER; ADIABATIC-PASSAGE; LASER-PULSES; STATES; ATOMS AB A control strategy incorporating a fixed carrier frequency constraint on the optimal field is presented. As an illustrative example we consider the creation of maximum coherence in a six-level Lambda system by solving the Schrodinger equation without the rotating-wave approximation in the field-interaction representation. We demonstrate that application of the optimal control theory optimization reformulated in the field-interaction representation allows one to keep the carrier frequency of the control field constant and successfully optimize off-resonant processes in multilevel quantum systems. C1 [Kumar, Praveen; Malinovskaya, Svetlana A.] Stevens Inst Technol, Dept Phys, Hoboken, NJ 07030 USA. [Kumar, Praveen] Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA. [Malinovsky, Vladimir S.] US Army Res Lab, Adelphi, MD 20783 USA. RP Kumar, P (reprint author), Stevens Inst Technol, Dept Phys, Hoboken, NJ 07030 USA. EM vsmalinovsky@gmail.com OI Malinovskaya, Svetlana/0000-0003-4125-3947 FU National Science Foundation [PHY11-25915, PHY12-05454] FX The authors thank Ignacio R. Sola for valuable discussions. This research was supported in part by the National Science Foundation under Grants No. PHY11-25915 and No. PHY12-05454. NR 30 TC 2 Z9 2 U1 0 U2 8 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 EI 1094-1622 J9 PHYS REV A JI Phys. Rev. A PD SEP 29 PY 2014 VL 90 IS 3 AR 033427 DI 10.1103/PhysRevA.90.033427 PG 5 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA AR6YZ UT WOS:000343728300007 ER PT J AU Kong, W Mohanta, A Roberts, AT Jiao, WY Fournelle, J Kim, TH Losurdo, M Everitt, HO Brown, AS AF Kong, W. Mohanta, A. Roberts, A. T. Jiao, W. Y. Fournelle, J. Kim, T. H. Losurdo, M. Everitt, H. O. Brown, A. S. TI Room temperature photoluminescence from InxAl(1-x)N films deposited by plasma-assisted molecular beam epitaxy SO APPLIED PHYSICS LETTERS LA English DT Article ID VAPOR-PHASE EPITAXY; STOKES SHIFT; ALLOYS; GAN; ALINN; TEMPLATES; DYNAMICS; LAYERS; INGAN; THICK AB InAlN films deposited by plasma-assisted molecular beam epitaxy exhibited a lateral composition modulation characterized by 10-12 nm diameter, honeycomb-shaped, columnar domains with Al-rich cores and In-rich boundaries. To ascertain the effect of this microstructure on its optical properties, room temperature absorption and photoluminescence characteristics of InxAl(1-x)N were comparatively investigated for indium compositions ranging from x = 0.092 to 0.235, including x = 0.166 lattice matched to GaN. The Stokes shift of the emission was significantly greater than reported for films grown by metalorganic chemical vapor deposition, possibly due to the phase separation in these nanocolumnar domains. The room temperature photoluminescence also provided evidence of carrier transfer from the InAlN film to the GaN template. (C) 2014 AIP Publishing LLC. C1 [Kong, W.; Jiao, W. Y.; Kim, T. H.; Brown, A. S.] Duke Univ, Dept Elect & Comp Engn, Durham, NC 27708 USA. [Mohanta, A.] US Army, AMRDEC, Res Participat Program, Oak Ridge Inst Sci & Educ, Redstone Arsenal, AL 35898 USA. [Roberts, A. T.; Everitt, H. O.] Army Aviat & Missile RD&E Ctr, Charles Bowden Res Lab, Redstone Arsenal, AL 35898 USA. [Fournelle, J.] Univ Wisconsin, Dept Geosci, Madison, WI 53706 USA. [Losurdo, M.] CNR, Plasma Chem Res Ctr, I-70126 Bari, Italy. [Everitt, H. O.] Duke Univ, Dept Phys, Durham, NC 27708 USA. RP Kong, W (reprint author), Duke Univ, Dept Elect & Comp Engn, Durham, NC 27708 USA. EM wei.kong@duke.edu RI Everitt, Henry/L-7118-2013; OI Everitt, Henry/0000-0002-8141-3768; LOSURDO, MARIA/0000-0002-8008-5192 FU ONR [N00014-08-1-0396]; GOALI NSF [NSF-ECCS-12-02132]; U.S. Army Aviation and Missile Research, Development and Engineering Center (AMRDEC) FX The authors would like to acknowledge the support of ONR N00014-08-1-0396, GOALI NSF NSF-ECCS-12-02132. This research was supported in part by appointment of A. Mohanta to the Postgraduate Research Participation Program at the U.S. Army Aviation and Missile Research, Development and Engineering Center (AMRDEC) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U. S. Department of Energy and AMRDEC. NR 26 TC 2 Z9 2 U1 3 U2 32 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD SEP 29 PY 2014 VL 105 IS 13 AR 132101 DI 10.1063/1.4896849 PG 5 WC Physics, Applied SC Physics GA AQ7XA UT WOS:000343031700028 ER PT J AU Yu, KM Novikov, SV Ting, M Sarney, WL Svensson, SP Shaw, M Martin, RW Walukiewicz, W Foxon, CT AF Yu, K. M. Novikov, S. V. Ting, Min Sarney, W. L. Svensson, S. P. Shaw, M. Martin, R. W. Walukiewicz, W. Foxon, C. T. TI Growth and characterization of highly mismatched GaN1-xSbx alloys SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID MOLECULAR-BEAM EPITAXY; BAND-GAP ENERGY; LAYERS; DEPENDENCE AB A systematic investigation on the effects of growth temperature, Ga flux, and Sb flux on the incorporation of Sb, film structure, and optical properties of the GaN1-xSbx highly mismatched alloys (HMAs) was carried out. We found that the direct bandgap ranging from 3.4 eV to below 1.0 eV for the alloys grown at low temperature. At the growth temperature of 80 degrees C, GaN1-xSbx with x>6% losses crystallinity and becomes primarily amorphous with small crystallites of 2-5 nm. Despite the range of microstructures found for GaN1-xSbx alloys with different composition, a well-developed absorption edge shifts from 3.4 eV (GaN) to close to 2 eV for samples with a small amount, less than 10% of Sb. Luminescence from dilute GaN1-xSbx alloys grown at high temperature and the bandgap energy for alloys with higher Sb content are consistent with a localized substitutional Sb level E-Sb at similar to 1.1 eV above the valence band of GaN. The decrease in the bandgap of GaN1-xSbx HMAs is consistent with the formation of a Sb-derived band due to the anticrossing interaction of the Sb states with the valence band of GaN. (C) 2014 AIP Publishing LLC. C1 [Yu, K. M.; Ting, Min; Walukiewicz, W.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA. [Novikov, S. V.; Foxon, C. T.] Univ Nottingham, Sch Phys & Astron, Nottingham NG7 2RD, England. [Ting, Min] Univ Calif Berkeley, Dept Mech Engn, Berkeley, CA 94720 USA. [Sarney, W. L.; Svensson, S. P.] US Army Res Lab, Adelphi, MD 20783 USA. [Shaw, M.; Martin, R. W.] Univ Strathclyde, Dept Phys, SUPA, Glasgow G4 0NG, Lanark, Scotland. RP Yu, KM (reprint author), Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Mat Sci, 1 Cyclotron Rd, Berkeley, CA 94720 USA. RI martin, rob/A-7127-2010; OI martin, rob/0000-0002-6119-764X; Yu, Kin Man/0000-0003-1350-9642 FU EPSRC [EP/I004203/1]; US Army [W911NF-12-2-0003] FX The MBE growth at the University of Nottingham was undertaken with support from the EPSRC (EP/I004203/1) and by the US Army under cooperative Agreement No. W911NF-12-2-0003. RBS and optical measurements performed at LBNL were supported by the U.S. Department of Energy, Office of Science, Basic Energy Sciences, Materials Sciences and Engineering Division. The characterization work at Strathclyde University was funded by EPSRC Grant No. EP/I004203/1. NR 23 TC 7 Z9 7 U1 0 U2 14 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD SEP 28 PY 2014 VL 116 IS 12 AR 123704 DI 10.1063/1.4896364 PG 8 WC Physics, Applied SC Physics GA AQ5HZ UT WOS:000342840000033 ER PT J AU Palomino, JM Tran, DT Hauser, JL Dong, H Oliver, SRJ AF Palomino, Jessica M. Tran, Dat T. Hauser, Jesse L. Dong, Hong Oliver, Scott R. J. TI Mesoporous silica nanoparticles for high capacity adsorptive desulfurization SO JOURNAL OF MATERIALS CHEMISTRY A LA English DT Article ID DEEP DESULFURIZATION; SELECTIVE ADSORPTION; JET FUEL; DIESEL FUEL; TRANSPORTATION FUELS; PI-COMPLEXATION; DRUG-DELIVERY; LIQUID FUELS; ADSORBENTS; GASOLINE AB Desulfurized JP-8 fuel is of great interest for use as the hydrogen feedstock of fuel cells. The refractory aromatic sulfur species present, however, are particularly challenging to remove through traditional methods. We report the first use of mesoporous silica nanoparticles (MSN) for desulfurization and the material displays a four-fold greater performance towards JP-8 fuel over previous sorbents. The bulk form of mesoporous silica shows three-fold greater level of desulfurization. Silver-impregnated nanoparticle and bulk MCM-41 were found to have saturation adsorption capacities of 32.6 mgS g(-1) and 25.4 mgS g(-1), respectively. MSN display a high capacity for the notoriously difficult to remove 4,6-dimethyldibenzothiophene along with a two-fold improvement in breakthrough capacity over previously published materials, of 0.98 mgS g(-1) at 10 ppm(w)S. C1 [Palomino, Jessica M.; Hauser, Jesse L.; Oliver, Scott R. J.] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA. [Tran, Dat T.] US Army Res Lab, RDRL SED C, Adelphi, MD 20783 USA. [Dong, Hong] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Tran, DT (reprint author), US Army Res Lab, RDRL SED C, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM dat.t.tran4.civ@mail.mil; soliver@ucsc.edu FU DOD ARL [W911NF-12-2-0005]; NSF Major Research Instrumentation (MRI) Program [DMR-1126845] FX This work was supported by DOD ARL, Contract no. W911NF-12-2-0005. The PXRD data in this work were recorded on an instrument supported by the NSF Major Research Instrumentation (MRI) Program under Grant DMR-1126845. We acknowledge Dr Tom Yuzvinsky for image acquisition and the W. M. Keck Center for Nanoscale Optofluidics at UC Santa Cruz for use of the FEI Quanta 3D Dualbeam microscope. ICP experiment assistance from Rob Franks in the Department of Earth and Marine Sciences at UC Santa Cruz is also acknowledged. NR 27 TC 23 Z9 24 U1 11 U2 74 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2050-7488 EI 2050-7496 J9 J MATER CHEM A JI J. Mater. Chem. A PD SEP 28 PY 2014 VL 2 IS 36 BP 14890 EP 14895 DI 10.1039/c4ta02570a PG 6 WC Chemistry, Physical; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Energy & Fuels; Materials Science GA AN7LJ UT WOS:000340781400016 ER PT J AU Sliozberg, YR Chantawansri, TL Lenhart, JL Andzelm, JW AF Sliozberg, Yelena R. Chantawansri, Tanya L. Lenhart, Joseph L. Andzelm, Jan W. TI Structural and mechanical properties of advanced polymer gels with rigid side-chains using coarse-grained molecular dynamics SO POLYMER LA English DT Article DE Polymer gels; Molecular dynamics simulation; Mechanical properties ID DOUBLE-NETWORK HYDROGELS; SOLVENT; STRESS; NANOCOMPOSITES; DEFORMATION; STRENGTH; RHEOLOGY; BEHAVIOR; FORCES AB Computational modeling was utilized to design complex polymer networks and gels which display enhanced and tunable mechanical properties. Our approach focuses on overcoming traditional design limitations often encountered in the formulation of simple, single polymer networks. Here, we use a coarse-grained model to study an end-linked flexible polymer network diluted with branched polymer solvent chains, where the latter chains are composed of rigid side-chains or "spikes" attached to a flexible backbone. In order to reduce the entropy penalty of the flexible polymer chains these rigid "spikes" will aggregate into clusters, but the extent of aggregation was shown to depend on the size and distribution of the rigid side-chains. When the "spikes" are short, we observe a lower degree of aggregation, while long "spikes" will aggregate to form an additional secondary network. As a result, the tensile relaxation modulus of the latter system is considerably greater than the modulus of conventional gels and is approximately constant, forming an equilibrium zone for a broad range of time. In this system, the attached long "spikes" create a continuous phase that contributes to a simultaneous increase in tensile stress, relaxation modulus and fracture resistance. Elastic properties and deformation mechanisms of these branched polymers were also studied under tensile deformation at various strain rates. Through this study we show that the architecture of this branched polymer can be optimized and thus the elastic properties of these advanced polymer networks can be tuned for specific applications. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Sliozberg, Yelena R.; Chantawansri, Tanya L.; Lenhart, Joseph L.; Andzelm, Jan W.] US Army Res Lab, RDRL WMM G, Aberdeen Proving Ground, MD 21005 USA. RP Andzelm, JW (reprint author), US Army Res Lab, RDRL WMM G, Aberdeen Proving Ground, MD 21005 USA. EM yelena.r.sliozberg.ctr@mail.mil; jan.w.andzelm.civ@mail.mil NR 41 TC 4 Z9 4 U1 2 U2 27 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 EI 1873-2291 J9 POLYMER JI Polymer PD SEP 26 PY 2014 VL 55 IS 20 BP 5266 EP 5275 DI 10.1016/j.polymer.2014.08.063 PG 10 WC Polymer Science SC Polymer Science GA AU2YC UT WOS:000345479400031 ER PT J AU Haskins, JB Bennett, WR Wu, JJ Hernandez, DM Borodin, O Monk, JD Bauschlicher, CW Lawson, JW AF Haskins, Justin B. Bennett, William R. Wu, James J. Hernandez, Dionne M. Borodin, Oleg Monk, Joshua D. Bauschlicher, Charles W., Jr. Lawson, John W. TI Computational and Experimental Investigation of Li-Doped Ionic Liquid Electrolytes: [pyr14][TFSI], [pyr13][FSI], and [EMIM][BF4] SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID MOLECULAR-DYNAMICS SIMULATIONS; BIS(TRIFLUOROMETHANESULFONYL) IMIDE ANION; POLARIZABLE FORCE-FIELDS; LITHIUM METAL-ELECTRODES; BIS(FLUOROSULFONYL) IMIDE; TRANSPORT-PROPERTIES; ELECTROCHEMICAL PROPERTIES; PHYSICOCHEMICAL PROPERTIES; PYRROLIDINIUM CATIONS; RAMAN-SPECTROSCOPY AB We employ molecular dynamics (MD) simulation and experiment to investigate the structure, thermodynamics, and transport of N-methyl-N-butylpyrrolidinium bis(trifluoromethylsufonyl)imide ([pyr14][TESI]), N-methyl-N-propylpyrrolidinium bis (fluorosufonyl)imide ([pyr13][FSI]), and 1-ethyl-3-methylimidazolium boron tetrafluoride ([EMIM][BF4]), as a function of Li-salt mole fraction (0.05 <= x(Li+) <= 0.33) and temperature (298 K <= T <= 393 K). Structurally, Li+ is shown to be solvated by three anion neighbors in [pyr14][TFSI] and four anion neighbors in both [pyr13][FSI] and [EMIM][BF4], and at all levels of x(Li+) we find the presence of lithium aggregates. Pulsed field gradient spin-echo NMR measurements of diffusion and electrochemical impedance spectroscopy measurements of ionic conductivity are made for the neat ionic liquids as well as 0.5 molal solutions of Li-salt in the ionic liquids. Bulk ionic liquid properties (density, diffusion, viscosity, and ionic conductivity) are obtained with MD simulations and show excellent agreement with experiment. While the diffusion exhibits a systematic decrease with increasing x(Li+), the contribution of Li+ to ionic conductivity increases until reaching a saturation doping level of x(Li+) = 0.10. Comparatively, the Li+ conductivity of [pyr14][TFSI] is an order of magnitude lower than that of the other liquids, which range between 0.1 and 0.3 mS/cm. Our transport results also demonstrate the necessity of long MD simulation runs (similar to 200 ns) to converge transport properties at room temperature. The differences in Li+ transport are reflected in the residence times of Li+ with the anions (tau(Li+/-)), which are revealed to be much larger for [pyr14][TESI] (up to 100 ns at the highest doping levels) than in either [EMIM][BF4] or [pyr13][FSI]. Finally, to comment on the relative kinetics of Li+ transport in each liquid, we find that while the net motion of Li+ with its solvation shell (vehicular) significantly contributes to net diffusion in all liquids, the importance of transport through anion exchange increases at high x(Li+) and in liquids with large anions. C1 [Haskins, Justin B.; Monk, Joshua D.] NASA, ERC Inc, Thermal Protect Mat & Syst Branch, Moffett Field, CA 94035 USA. [Bauschlicher, Charles W., Jr.] NASA, Entry Syst & Technol Div, Moffett Field, CA 94035 USA. [Lawson, John W.] NASA, Thermal Protect Mat & Syst Branch, Ames Res Ctr, Moffett Field, CA 94035 USA. [Bennett, William R.; Wu, James J.; Hernandez, Dionne M.] NASA, Electrochem Branch, Glenn Res Ctr, Cleveland, OH 44135 USA. [Borodin, Oleg] US Army Res Lab, Electrochem Branch, Sensor & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Lawson, JW (reprint author), NASA, Thermal Protect Mat & Syst Branch, Ames Res Ctr, Moffett Field, CA 94035 USA. EM john.w.lawson@nasa.gov RI Borodin, Oleg/B-6855-2012 OI Borodin, Oleg/0000-0002-9428-5291 FU NASA Aeronautics Research Institute (NARI) Seedling program FX This work was supported by funding from the NASA Aeronautics Research Institute (NARI) Seedling program. NR 61 TC 22 Z9 22 U1 9 U2 78 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1520-6106 J9 J PHYS CHEM B JI J. Phys. Chem. B PD SEP 25 PY 2014 VL 118 IS 38 BP 11295 EP 11309 DI 10.1021/jp5061705 PG 15 WC Chemistry, Physical SC Chemistry GA AP9JL UT WOS:000342396000027 PM 25159701 ER PT J AU Fu, R Shi, JM Forsythe, E Blomquist, S Srour, M Morton, D AF Fu, Richard Shi, Jianmin Forsythe, Eric Blomquist, Steven Srour, Merric Morton, David TI Improvement of device efficiency for blue organic light emitting diodes by controlling the Cs2CO3-doped electron transport layer SO JOURNAL OF PHOTONICS FOR ENERGY LA English DT Article DE organic materials; optical devices; luminescence ID ELECTROLUMINESCENT DEVICES; INJECTION AB The electronic transport properties of 1, 3, 5-tri(1-phenyl-1H-benzo[d]imidazol-2-yl) phenyl (TPBI) electron transporting layers (ETLs) have been investigated as a function of cesium carbonate (Cs2CO3) doping for organic light-emitting diodes (OLEDs). The current density-voltage and light emission characteristics were measured as a function of the Cs2CO3-doped ETL thickness. Cs2CO3-doped TPBI decreased OLED operating voltage by 26% and increased device luminance by 17% in a wide concentration range (3.5% to 10.5%) compared to undoped devices. The effects of 7% Cs2CO3-doped ETL thickness indicated that the operating voltage continuously decreased to 37% when the ETL thickness increased to 600 angstrom and luminance output continued to increasto 21% at ETL thickness 525 angstrom. The blue OLED can be optimized by adjusting the thicknesses of Cs2CO3-doped TPBI ETL to balance the electron and hole injection. (C) 2014 Society of Photo-Optical Instrumentation Engineers (SPIE) C1 [Fu, Richard; Shi, Jianmin; Forsythe, Eric; Blomquist, Steven; Srour, Merric; Morton, David] US Army Res Lab, Adelphi, MD 20783 USA. RP Fu, R (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM richard.x.fu.civ@mail.mil NR 30 TC 2 Z9 2 U1 5 U2 37 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 1947-7988 J9 J PHOTON ENERGY JI J. Photonics Energy PD SEP 24 PY 2014 VL 4 AR 043595 DI 10.1117/1.JPE.4.043595 PG 7 WC Materials Science, Multidisciplinary; Optics; Physics, Applied SC Materials Science; Optics; Physics GA AR9EU UT WOS:000343876000001 ER PT J AU Cooley, KA Pearl, TP Varady, MJ Mantooth, BA Willis, MP AF Cooley, Kayla A. Pearl, Thomas P. Varady, Mark J. Mantooth, Brent A. Willis, Matthew P. TI Direct Measurement of Chemical Distributions in Heterogeneous Coatings SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE SEM; EDS; CEES; DMMP; military coatings; molecular absorption; chemical distribution ID SPECTROSCOPY; DEGRADATION; DIFFUSION; TRANSPORT; SYSTEMS; FILMS AB Chemical warfare agents (CWA) can be absorbed by variety of materials including polymeric coatings like paints through bulk liquid contact, thus presenting touch and vapor hazards to interacting personnel. In order for accurate hazard assessments and subsequent decontamination approaches to be designed, it is necessary to characterize the absorption and distribution of highly toxic species, as well as their chemical simulant analogs, in the subsurface of engineered, heterogeneous materials. Using a combination of judicious sample preparation in concert with scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS), it should be possible to directly measure the uptake and distribution of CWA simulants in the subsurface of complex multilayer coatings. Polyurethane and alkyd coatings were applied to aluminum and silicon substrates and contaminated with 2-chloroethyl ethyl sulfide (CEES) and dimethyl methylphosphonate (DMMP). The surfaces and cross-sectional interfaces of the contaminated coatings were probed with SEM-EDS to provide imaging, spectral, and elemental mapping data of the contaminant-material systems. This work demonstrated SEM-EDS capability to detect and spatially resolve unique elemental signatures of CWA simulants within military coatings. The visual and quantitative results provided by these direct measurements illustrate contaminant spatial distributions, provide order-of-magnitude approximations for diffusion coefficients, and reveal material characteristics that may impact contaminant transport into complex coating materials. It was found that contaminant uptake was significantly different between the topcoat and primer layers. C1 [Cooley, Kayla A.; Pearl, Thomas P.; Varady, Mark J.] OptiMetrics Inc, Abingdon, MD 21009 USA. [Mantooth, Brent A.; Willis, Matthew P.] US Army Edgewood Chem Biol Ctr, Decontaminat Sci Branch, Aberdeen Proving Ground, MD 21010 USA. RP Willis, MP (reprint author), US Army Edgewood Chem Biol Ctr, Decontaminat Sci Branch, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM matthew.p.willis.civ@mail.mil RI Cooley, Kayla/E-1952-2016 OI Cooley, Kayla/0000-0002-6598-4296 FU Defense Threat Reduction Agency (DTRA) [BO09MSB317] FX The authors thank Eric Lowenstein and Michael Roberts at the Defense Threat Reduction Agency (DTRA) for funding this work under contract BO09MSB317. The authors thank John Escarsega of the Army Research Laboratory and Alicia Farrell of Dynamic Science, Inc. for helpful discussions and for preparing the coating samples. The authors thank Brian Luthardt of Leidos for testing support. NR 14 TC 3 Z9 3 U1 3 U2 30 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD SEP 24 PY 2014 VL 6 IS 18 BP 16289 EP 16296 DI 10.1021/am504487j PG 8 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA AP8KQ UT WOS:000342328300080 PM 25148420 ER PT J AU Zhu, LL Tran, H Beyer, FL Walck, SD Li, X Agren, H Killops, KL Campos, LM AF Zhu, Liangliang Tran, Helen Beyer, Frederick L. Walck, Scott D. Li, Xin Agren, Hans Killops, Kato L. Campos, Luis M. TI Engineering Topochemical Polymerizations Using Block Copolymer Templates SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY LA English DT Article ID ASSEMBLED DIACETYLENE MACROCYCLE; SOLID-STATE POLYMERIZATION; MAGNETIC-FIELD ALIGNMENT; SINGLE-CRYSTAL; PHOTOCHEMICAL-REACTIONS; CONJUGATED POLYMER; SIDE-CHAIN; DESIGN; DIPHENYLDIACETYLENE; POLYDIACETYLENES AB With the aim to achieve rapid and efficient topochemical polymerizations in the solid state, via solution-based processing of thin films, we report the integration of a diphenyldiacetylene monomer and a poly(styrene-b-acrylic acid) block copolymer template for the generation of supramolecular architectural photopolymerizable materials. This strategy takes advantage of non-covalent interactions to template a topochemical photopolymerization that yields a polydiphenyldiacetylene (PDPDA) derivative. In thin films, it was found that hierarchical self-assembly of the diacetylene monomers by microphase segregation of the block copolymer template enhances the topochemical photopolymerization, which is complete within a 20 s exposure to UV light. Moreover, UV-active cross-linkable groups were incorporated within the block copolymer template to create micropattems of PDPDA by photolithography, in the same step as the polymerization reaction. The materials design and processing may find potential uses in the microfabrication of sensors and other important areas that benefit from solution-based processing of flexible conjugated materials. C1 [Zhu, Liangliang; Tran, Helen; Campos, Luis M.] Columbia Univ, Dept Chem, New York, NY 10027 USA. [Beyer, Frederick L.; Walck, Scott D.] Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Li, Xin; Agren, Hans] KTH Royal Inst Technol, Div Theoret Chem & Biol, Sch Biotechnol, SE-10691 Stockholm, Sweden. [Killops, Kato L.] Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Killops, KL (reprint author), Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM kathryn.l.killops.civ@mail.mil; lcampos@columbia.edu RI Li, Xin/F-1514-2010; Zhu, Liangliang/E-4820-2013; Agren, Hans/H-7715-2016 OI Li, Xin/0000-0001-6508-8355; FU Department of the Army Basic Research Program; Edgewood Chemical Biological Center; Army Research Office [W911NF-12-1-0252]; NSF CAREER [DMR-1351293]; Department of Defense (DOD); Army Basic Research Program FX This research was funded by the Department of the Army Basic Research Program and sponsored by the Edgewood Chemical Biological Center. Financial support for L.Z. was provided by the Army Research Office under award number W911NF-12-1-0252. The self-assembly characterization was funded by an NSF CAREER grant (DMR-1351293). H.T. thanks the Department of Defense (DOD) for the National Defense Science & Engineering Graduate (NDSEG) Fellowship. K.L.K. thanks the Army Basic Research Program for funding. We thank Dr. J. Xia and Dr. S. Wei for helpful discussions and D. Hanifi for the assistance with the GISAXS studies. NR 59 TC 15 Z9 16 U1 9 U2 100 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0002-7863 J9 J AM CHEM SOC JI J. Am. Chem. Soc. PD SEP 24 PY 2014 VL 136 IS 38 BP 13381 EP 13387 DI 10.1021/ja507318u PG 7 WC Chemistry, Multidisciplinary SC Chemistry GA AP8KP UT WOS:000342328200055 PM 25208609 ER PT J AU Lisenkov, I Tyberkevych, V Slavin, A Bondarenko, P Ivanov, BA Bankowski, E Meitzler, T Nikitov, S AF Lisenkov, Ivan Tyberkevych, Vasyl Slavin, Andrei Bondarenko, Pavel Ivanov, Boris A. Bankowski, Elena Meitzler, Thomas Nikitov, Sergey TI Spin-wave edge modes in finite arrays of dipolarly coupled magnetic nanopillars SO PHYSICAL REVIEW B LA English DT Article AB The frequency spectrum of spin-wave edge modes localized near the boundaries of a finite array of dipolarly coupled magnetic nanopillars is calculated theoretically. Two mechanisms of edge mode formation are revealed: inhomogeneity of the internal static magnetic field existing near the array boundaries and time-reversal symmetry breaking of the dipole-dipole interaction. The latter mechanism is analogous to the formation mechanism of a surface Damon-Eschbach mode in continuous in-plane magnetized magnetic films and is responsible for the nonreciprocity of edge modes in finite-width nanopillar arrays. The number of edge modes in nanopillar arrays depends on the spatial profile of the internal static magnetic field near the array boundaries and several edge modes are formed if a substantial field inhomogeneity extends over several rows of nanopillars. C1 [Lisenkov, Ivan; Tyberkevych, Vasyl; Slavin, Andrei] Oakland Univ, Dept Phys, Rochester, MI 48309 USA. [Lisenkov, Ivan; Nikitov, Sergey] RAS, Kotelnikov Inst Radioengn & Elect, Moscow 125009, Russia. [Bondarenko, Pavel; Ivanov, Boris A.] Natl Acad Sci, Inst Magnetism, Kiev, Ukraine. [Bondarenko, Pavel; Ivanov, Boris A.] Taras Shevchenko Natl Univ Kiev, UA-03127 Kiev, Ukraine. [Bankowski, Elena; Meitzler, Thomas] US Army TARDEC, Warren, MI 48397 USA. [Nikitov, Sergey] Moscow Inst Phys & Technol, Dolgoprudnyi 141700, Moscow Region, Russia. [Nikitov, Sergey] Saratov NG Chernyshevskii State Univ, Saratov 410012, Russia. RP Lisenkov, I (reprint author), Oakland Univ, Dept Phys, 2200 N Squirrel Rd, Rochester, MI 48309 USA. EM ivan.lisenkov@phystech.edu RI Lisenkov, Ivan/G-7600-2016 OI Lisenkov, Ivan/0000-0002-7013-9169 FU National Science Foundation of the USA [DMR-1015175]; US Army TARDEC, RDECOM; DARPA grant; Russian Scientific Foundation [14-19-00760] FX This work was supported in part by the Grant No. DMR-1015175 from the National Science Foundation of the USA, by the contract from the US Army TARDEC, RDECOM, and by the DARPA grant "Coherent Information Transduction between Photons, Magnons, and Electric Charge Carriers". I.L. and S.N. acknowledge the Russian Scientific Foundation, Grant No. 14-19-00760 for financial support. NR 19 TC 15 Z9 15 U1 1 U2 11 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9950 EI 2469-9969 J9 PHYS REV B JI Phys. Rev. B PD SEP 22 PY 2014 VL 90 IS 10 AR 104417 DI 10.1103/PhysRevB.90.104417 PG 5 WC Physics, Condensed Matter SC Physics GA AS1CL UT WOS:000344014700004 ER PT J AU Alving, CR Matyas, GR Torres, O Jalah, R Beck, Z AF Alving, Carl R. Matyas, Gary R. Torres, Oscar Jalah, Rashmi Beck, Zoltan TI Adjuvants for vaccines to drugs of abuse and addiction SO VACCINE LA English DT Review DE Adjuvants; Immunotherapeutic vaccines; Morphine; Heroin; Cocaine; Nicotine; Methamphetamine; Oxycodone; Hydrocodone ID THERAPEUTIC COCAINE VACCINE; WATER LIPOSOMAL EMULSIONS; NICOTINE VACCINE; MORPHINE/HEROIN VACCINE; ACTIVE IMMUNIZATION; SMOKING-CESSATION; MALARIA VACCINE; SUBSTANCE-ABUSE; HEPATITIS-B; LIPID-A AB Immunotherapeutic vaccines to drugs of abuse, including nicotine, cocaine, heroin, oxycodone, methamphetamine, and others are being developed. The theoretical basis of such vaccines is to induce antibodies that sequester the drug in the blood in the form of antibody-bound drug that cannot cross the blood brain barrier, thereby preventing psychoactive effects. Because the drugs are haptens a successful vaccine relies on development of appropriate hapten-protein carrier conjugates. However, because induction of high and prolonged levels of antibodies is required for an effective vaccine, and because injection of T-independent haptenic drugs of abuse does not induce memory recall responses, the role of adjuvants during immunization plays a critical role. As reviewed herein, preclinical studies often use strong adjuvants such as complete and incomplete Freund's adjuvant and others that cannot be, or in the case of many newer adjuvants, have never been, employed in humans. Balanced against this, the only adjuvant that has been included in candidate vaccines in human clinical trials to nicotine and cocaine has been aluminum hydroxide gel. While aluminum salts have been widely utilized worldwide in numerous licensed vaccines, the experience with human responses to aluminum salt-adjuvanted vaccines to haptenic drugs of abuse has suggested that the immune responses are too weak to allow development of a successful vaccine. What is needed is an adjuvant or combination of adjuvants that are safe, potent, widely available, easily manufactured, and cost-effective. Based on our review of the field we recommend the following adjuvant combinations either for research or for product development for human use: aluminum salt with adsorbed monophosphoryl lipid A (MPLA); liposomes containing MPLA [L(MPLA)]; L(MPLA) adsorbed to aluminum salt; oil-in-water emulsion; or oil-in-water emulsion containing MPLA. (C) 2014 Published by Elsevier Ltd. C1 [Alving, Carl R.; Matyas, Gary R.; Torres, Oscar; Jalah, Rashmi; Beck, Zoltan] Walter Reed Army Inst Res, US Mil HIV Res Program, Lab Adjuvant & Antigen Res, Silver Spring, MD 20910 USA. [Torres, Oscar; Jalah, Rashmi; Beck, Zoltan] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Bethesda, MD 20817 USA. RP Alving, CR (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Lab Adjuvant & Antigen Res, Silver Spring, MD 20910 USA. EM calving@hivresearch.org OI Matyas, Gary/0000-0002-2074-2373 FU Henry M. Jackson Foundation for the Advancement of Military Medicine [W81XWH-07-2-067]; U.S. Army Medical Research and Materiel Command (MRMC) [W81XWH-07-2-067]; Avant Garde award from the National Institute on Drug Abuse (NIH) [1DP1DA034787-01] FX This work was supported through a Cooperative Agreement Award (no.W81XWH-07-2-067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the U.S. Army Medical Research and Materiel Command (MRMC). The work was partially supported by an Avant Garde award (to GRM) from the National Institute on Drug Abuse (NIH grant no. 1DP1DA034787-01). The views expressed in this article are those of the authors and do not necessarily reflect the official policy of the Department of the Army, Department of Defense, or the U.S. Government. NR 102 TC 15 Z9 16 U1 2 U2 26 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD SEP 22 PY 2014 VL 32 IS 42 BP 5382 EP 5389 DI 10.1016/j.vaccine.2014.07.085 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA AR1LH UT WOS:000343346200004 PM 25111169 ER PT J AU Hill, SC Doughty, DC Pan, YL Williamson, C Santarpia, JL Hill, HH AF Hill, Steven C. Doughty, David C. Pan, Yong-Le Williamson, Chatt Santarpia, Joshua L. Hill, Hanna H. TI Fluorescence of bioaerosols: mathematical model including primary fluorescing and absorbing molecules in bacteria: errata SO OPTICS EXPRESS LA English DT Article AB In our publication [Opt. Express, 20(19), 22285-22313 (2013)] a coding error caused an incorrect value of absorptivity to be used for tyrosine. Tables showing the corrected results are shown. (C) 2014 Optical Society of America C1 [Hill, Steven C.; Doughty, David C.; Pan, Yong-Le; Williamson, Chatt] US Army Res Lab, Adelphi, MD 20783 USA. [Santarpia, Joshua L.] Sandia Natl Labs, Albuquerque, NM USA. RP Hill, SC (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM steven.c.hill32.civ@mail.mil NR 1 TC 2 Z9 2 U1 2 U2 9 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD SEP 22 PY 2014 VL 22 IS 19 BP 22817 EP 22819 DI 10.1364/OE.22.022817 PG 3 WC Optics SC Optics GA AQ4IB UT WOS:000342756500055 ER PT J AU Gosalvez, J Lopez-Fernandez, C Hermoso, A Fernandez, JL Kjelland, ME AF Gosalvez, Jaime Lopez-Fernandez, Carmen Hermoso, Ana Fernandez, Jose Luis Kjelland, Michael E. TI Sperm DNA fragmentation in zebrafish (Danio rerio) and its impact on fertility and embryo viability - Implications for fisheries and aquaculture SO AQUACULTURE LA English DT Article DE DNA fragmentation; Embryo; Fertility; Sperm; Zebrafish (Danio rerio) ID DOMESTIC-ANIMALS; DYNAMICS; DAMAGE; REPRODUCTION; APOPTOSIS; EXPOSURE; SPERMATOZOA; CRYOINJURY; ACTIVATION; TRANSITION AB Sperm DNA damage is one of the many factors that have been associated with male infertility. However, sperm DNA fragmentation (SDF) assessment has been challenging because protamines render the nuclear chromatin highly compacted. For those fish species having sperm with protamines, one hypothesis is that the less compacted DNA could be more vulnerable to iatrogenic damage when used in artificial reproduction. The present investigation included three objectives: 1) apply the Sperm Chromatin Dispersion (SCD) technique using the Halomax-SCD test kit (Halotech DNA, Madrid, Spain) for the rapid assessment of SDF in zebrafish (Danio rerio); 2) assess the dynamic aspects of SCD to determine zebrafish sperm DNA longevity in both activated and unactivated samples; and 3) to analyze if the dynamic level of zebrafish sperm DNA fragmentation has any impact on fertility and embryo viability. The results demonstrate the use of the Halomax-SCD test for assessing SDF in zebrafish and are congruent with results of DNA Breakage Detection-Fluorescence In Situ Hybridization (DBD-FISH) and Comet Assay. The averaged SDF values derived from 10 individuals were low immediately after sperm motility activation (1.4% +/- 0.96) compared to 15 min later (10.6% +/- 9.96), with increasing and very high rates of SDF (r-SDF), 0.6% units/min. Although SDF did not significantly influence oocyte fertilization capacity, it significantly impacted later embryo development and overall reproductive success, i.e., fertility rates higher than embryo viability values. Published by Elsevier B.V. C1 [Gosalvez, Jaime; Lopez-Fernandez, Carmen; Hermoso, Ana] Univ Autonoma Madrid, Unidad Genet, Dept Biol, Madrid 20849, Spain. [Fernandez, Jose Luis] Complejo Hosp Univ A Coruna INIBIC, Unidad Genet, La Coruna 15006, Spain. [Kjelland, Michael E.] Conservat Genet & Biotech LLC, Vicksburg, MS 39182 USA. [Kjelland, Michael E.] US Army, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Kjelland, ME (reprint author), US Army, Engn Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM jaime.gosalvez@uam.es; mariadelcarmen.lopez@uam.es; anahermoso@gmail.com; joseluis.femandez@cog.es; Michael.E.Kjelland@usace.army.mil FU Ministry of Education and Science, Spain [BFU2010-16738/BFI] FX This work was supported by the Ministry of Education and Science, Spain (Grant BFU2010-16738/BFI). NR 51 TC 2 Z9 3 U1 0 U2 24 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0044-8486 EI 1873-5622 J9 AQUACULTURE JI Aquaculture PD SEP 20 PY 2014 VL 433 BP 173 EP 182 DI 10.1016/j.aquaculture.2014.05.036 PG 10 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA AQ1GH UT WOS:000342529400026 ER PT J AU Servinsky, MD Liu, SC Gerlach, ES Germane, KL Sund, CJ AF Servinsky, Matthew D. Liu, Sanchao Gerlach, Elliot S. Germane, Katherine L. Sund, Christian J. TI Fermentation of oxidized hexose derivatives by Clostridium acetobutylicum SO MICROBIAL CELL FACTORIES LA English DT Article DE Clostridium acetobutylicum; Fermentation; Gluconate; Galacturonate; Acetate; Pectin; Hydrogen; Carbon dioxide ID ACETONE-BUTANOL FERMENTATION; HYDROGEN-PRODUCTION; PHOSPHOKETOLASE PATHWAY; ESCHERICHIA-COLI; ELECTRON FLOW; ATCC 824; METABOLISM; PH; PRODUCTS; BACTERIA AB Background: Clostridium acetobutylicum fermentations are promising for production of commodity chemicals from heterogeneous biomass due to the wide range of substrates the organism can metabolize. Much work has been done to elucidate the pathways for utilization of aldoses, but little is known about metabolism of more oxidized substrates. Two oxidized hexose derivatives, gluconate and galacturonate, are present in low cost feedstocks, and their metabolism will contribute to overall metabolic output of these substrates. Results: A complete metabolic network for glucose, gluconate, and galacturonate utilization was generated using online databases, previous studies, genomic context, and experimental data. Gluconate appears to be metabolized via the Entner-Doudoroff pathway, and is likely dehydrated to 2-keto-3-deoxy-gluconate before phosphorylation to 2-keto-3-deoxy-6-P-gluconate. Galacturonate appears to be processed via the Ashwell pathway, converging on a common metabolite for gluconate and galacturonate metabolism, 2-keto-3-deoxygluconate. As expected, increasingly oxidized substrates resulted in increasingly oxidized products with galacturonate fermentations being nearly homoacetic. Calculations of expected ATP and reducing equivalent yields and experimental data suggested galacturonate fermentations were reductant limited. Galacturonate fermentation was incomplete, which was not due solely to product inhibition or the inability to utilize low concentrations of galacturonate. Removal of H-2 and CO2 by agitation resulted in faster growth, higher cell densities, formation of relatively more oxidized products, and higher product yields for cultures grown on glucose or gluconate. In contrast, cells grown on galacturonate showed reduced growth rates upon agitation, which was likely due to loss in reductant in the form of H-2. The growth advantage seen on agitated glucose or gluconate cultures could not be solely attributed to improved ATP economics, thereby indicating other factors are also important. Conclusions: The metabolic network presented in this work should facilitate similar reconstructions in other organisms, and provides a further understanding of the pathways involved in metabolism of oxidized feedstocks and carbohydrate mixtures. The nearly homoacetic fermentation during growth on galacturonate indicates further optimization of this and related organisms could provide a route to an effective biologically derived acetic acid production platform. Furthermore, the pathways could be targeted to decrease production of undesirable products during fermentations of heterogeneous biomass. C1 [Servinsky, Matthew D.; Sund, Christian J.] US Army Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. [Liu, Sanchao; Gerlach, Elliot S.] Fed Staffing Resources, Annapolis, MD 21401 USA. [Germane, Katherine L.] Oak Ridge Associated Univ, Belcamp, MD 21017 USA. RP Sund, CJ (reprint author), US Army Res Lab, Sensors & Elect Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM christian.j.sund.civ@mail.mil OI germane, katherine/0000-0002-5191-2670 NR 62 TC 5 Z9 5 U1 3 U2 23 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2859 J9 MICROB CELL FACT JI Microb. Cell. Fact. PD SEP 18 PY 2014 VL 13 AR 139 DI 10.1186/s12934-014-0139-7 PG 12 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA AQ2EM UT WOS:000342598600001 PM 25231163 ER PT J AU Chantawansri, TL Sirk, TW Mrozek, R Lenhart, JL Kroger, M Sliozberg, YR AF Chantawansri, Tanya L. Sirk, Timothy W. Mrozek, Randy Lenhart, Joseph L. Kroeger, Martin Sliozberg, Yelena R. TI The effect of polymer chain length on the mechanical properties of triblock copolymer gels SO CHEMICAL PHYSICS LETTERS LA English DT Article ID THERMOPLASTIC ELASTOMER GELS; DISSIPATIVE PARTICLE DYNAMICS; SELECTIVE SOLVENT; MORPHOLOGY; RHEOLOGY; SIMULATION; TEMPERATURE; ELASTICITY; NETWORKS; BEHAVIOR AB An ABA triblock copolymer in a midblock selective solvent is studied as a function of the chain length, using a novel dissipative particle dynamics (DPD) model which includes a modified segmental repulsive potential (mSRP) that restricts chain crossing. Deformation under uniaxial tension using the DPD method, with and without the mSRP, was used to extract the cross-link and entanglement portions of the modulus. The results exhibit the expected theoretical scaling with chain length for lower strain rates. Structural properties, such as bridge fraction and the extent of entanglements in the polymer matrix, were also quantified. Published by Elsevier B.V. C1 [Chantawansri, Tanya L.; Sirk, Timothy W.; Mrozek, Randy; Lenhart, Joseph L.; Sliozberg, Yelena R.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Kroeger, Martin] Swiss Fed Inst Technol, Dept Mat, CH-8093 Zurich, Switzerland. RP Chantawansri, TL (reprint author), US Army, Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. EM tanya.chantawansri.civ@mail.mil RI Kroger, Martin/C-1946-2008 OI Kroger, Martin/0000-0003-1402-6714 FU U.S. Army Research Laboratory FX TWS was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARL. Calculations were performed on DOD High Performance Computing site at the AFRL through the Challenge Project C5M. NR 30 TC 7 Z9 7 U1 7 U2 47 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 EI 1873-4448 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD SEP 18 PY 2014 VL 612 BP 157 EP 161 DI 10.1016/j.cplett.2014.08.013 PG 5 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA AQ1MQ UT WOS:000342545900028 ER PT J AU Tawa, GJ AbdulHameed, MDM Yu, XP Kumar, K Ippolito, DL Lewis, JA Stallings, JD Wallqvist, A AF Tawa, Gregory J. AbdulHameed, Mohamed Diwan M. Yu, Xueping Kumar, Kamal Ippolito, Danielle L. Lewis, John A. Stallings, Jonathan D. Wallqvist, Anders TI Characterization of Chemically Induced Liver Injuries Using Gene Co-Expression Modules SO PLOS ONE LA English DT Article ID DRUG DISCOVERY; INDUCED HEPATOTOXICITY; UNDERSTAND MECHANISMS; DATA SETS; TOXICITY; DATABASE; FIBROSIS; TOXICOGENOMICS; INTEGRATION; EXPRESSION AB Liver injuries due to ingestion or exposure to chemicals and industrial toxicants pose a serious health risk that may be hard to assess due to a lack of non-invasive diagnostic tests. Mapping chemical injuries to organ-specific damage and clinical outcomes via biomarkers or biomarker panels will provide the foundation for highly specific and robust diagnostic tests. Here, we have used DrugMatrix, a toxicogenomics database containing organ-specific gene expression data matched to dose-dependent chemical exposures and adverse clinical pathology assessments in Sprague Dawley rats, to identify groups of co-expressed genes (modules) specific to injury endpoints in the liver. We identified 78 such gene co-expression modules associated with 25 diverse injury endpoints categorized from clinical pathology, organ weight changes, and histopathology. Using gene expression data associated with an injury condition, we showed that these modules exhibited different patterns of activation characteristic of each injury. We further showed that specific module genes mapped to 1) known biochemical pathways associated with liver injuries and 2) clinically used diagnostic tests for liver fibrosis. As such, the gene modules have characteristics of both generalized and specific toxic response pathways. Using these results, we proposed three gene signature sets characteristic of liver fibrosis, steatosis, and general liver injury based on genes from the co-expression modules. Out of all 92 identified genes, 18 (20%) genes have well-documented relationships with liver disease, whereas the rest are novel and have not previously been associated with liver disease. In conclusion, identifying gene co-expression modules associated with chemically induced liver injuries aids in generating testable hypotheses and has the potential to identify putative biomarkers of adverse health effects. C1 [Tawa, Gregory J.; AbdulHameed, Mohamed Diwan M.; Yu, Xueping; Kumar, Kamal; Wallqvist, Anders] US Army Med Res & Mat Command, Dept Def High Performance Comp Software Applicat, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. [Ippolito, Danielle L.; Lewis, John A.; Stallings, Jonathan D.] US Army Ctr Environm Hlth Res, Ft Detrick, MD USA. RP Tawa, GJ (reprint author), US Army Med Res & Mat Command, Dept Def High Performance Comp Software Applicat, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. EM gtawa@bhsai.org; awallqvist@bhsai.org RI AbdulHameed, Mohamed Diwan M/O-3088-2015; OI AbdulHameed, Mohamed Diwan M/0000-0003-1483-4084; Stallings, Jonathan/0000-0002-6430-5888; Kumar, Kamal/0000-0002-9470-6682; wallqvist, anders/0000-0002-9775-7469 FU Military Operational Medicine Research Program; U.S. Army's Network Science Initiative, U.S. Army Medical Research and Materiel Command, Ft. Detrick, MD FX The authors were supported by the Military Operational Medicine Research Program and the U.S. Army's Network Science Initiative, U.S. Army Medical Research and Materiel Command (mrmc.amedd.army.mil), Ft. Detrick, MD. This research was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Center for Environmental Health Research (usacehr.amedd.army.mil) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USAMRMC. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 57 TC 9 Z9 9 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD SEP 16 PY 2014 VL 9 IS 9 AR e107230 DI 10.1371/journal.pone.0107230 PG 17 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AS5NP UT WOS:000344317700037 PM 25226513 ER PT J AU Wender, BA Foley, RW Prado-Lopez, V Ravikumar, D Eisenberg, DA Hottle, TA Sadowski, J Flanagan, WP Fisher, A Laurin, L Bates, ME Linkov, I Seager, TP Fraser, MP Guston, DH AF Wender, Ben A. Foley, Rider W. Prado-Lopez, Valentina Ravikumar, Dwarakanath Eisenberg, Daniel A. Hottle, Troy A. Sadowski, Jathan Flanagan, William P. Fisher, Angela Laurin, Lise Bates, Matthew E. Linkov, Igor Seager, Thomas P. Fraser, Matthew P. Guston, David H. TI Illustrating Anticipatory Life Cycle Assessment for Emerging Photovoltaic Technologies SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID EFFICIENCY; EMISSIONS; RISK; NANOMATERIALS; EXPOSURE AB Current research policy and strategy documents recommend applying life cycle assessment (LCA) early in research and development (R&D) to guide emerging technologies toward decreased environmental burden. However, existing LCA practices are ill-suited to support these recommendations. Barriers related to data availability, rapid technology change, and isolation of environmental from technical research inhibit application of LCA to developing technologies. Overcoming these challenges requires methodological advances that help identify environmental opportunities prior to large R&D investments. Such an anticipatory approach to LCA requires synthesis of social, environmental, and technical knowledge beyond the capabilities of current practices. This paper introduces a novel framework for anticipatory LCA that incorporates technology forecasting, risk research, social engagement, and comparative impact assessment, then applies this framework to photovoltaic (PV) technologies. These examples illustrate the potential for anticipatory LCA to prioritize research questions and help guide environmentally responsible innovation of emerging technologies. C1 [Wender, Ben A.; Prado-Lopez, Valentina; Ravikumar, Dwarakanath; Eisenberg, Daniel A.; Hottle, Troy A.; Seager, Thomas P.; Fraser, Matthew P.] Arizona State Univ, Sch Sustainable Engn & Built Environm, Tempe, AZ 85287 USA. [Wender, Ben A.; Foley, Rider W.; Guston, David H.] Arizona State Univ, Ctr Nanotechnol Soc, Tempe, AZ 85287 USA. [Wender, Ben A.; Seager, Thomas P.; Fraser, Matthew P.] Arizona State Univ, NSF DOE Engn Res Ctr, Tempe, AZ 85287 USA. [Sadowski, Jathan; Guston, David H.] Arizona State Univ, Consortium Sci Policy & Outcomes, Tempe, AZ 85287 USA. [Flanagan, William P.; Fisher, Angela] GE Co, Ecoassessment Ctr Excellence, Niskayuna, NY 12309 USA. [Laurin, Lise] EarthShift LLC, Kittery, ME 03904 USA. [Bates, Matthew E.; Linkov, Igor] US Army Corps Engineers, US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Foley, Rider W.] Univ Virginia, Vicksburg, VA 22904 USA. RP Wender, BA (reprint author), Arizona State Univ, Sch Sustainable Engn & Built Environm, Tempe, AZ 85287 USA. EM bwender@asu.edu OI Hottle, Troy/0000-0001-8459-1765 FU U.S. Environmental Protection Agency's (EPA) Science to Achieve Results program [FP917643]; National Science Foundation (NSF) [1144616, 1140190, 0937591]; NSF; Department of Energy (DOE) [1041895] FX This material is based upon work partially supported by the U.S. Environmental Protection Agency's (EPA) Science to Achieve Results program through grant #FP917643, the National Science Foundation (NSF) under grant #1144616, #1140190, and #0937591, and in part by the NSF and Department of Energy (DOE) under grant #1041895. Any opinions, findings, conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the EPA, NSF, or DOE. We benefitted from the National Nanotechnology Initiative workshop on Perception, Assessment, and Management of the Potential Risks of Nanotechnology, as well as the discussions with Dr. Fred Klaessig, Dr. Yu Yang, and Dr. Robert Reed. NR 59 TC 19 Z9 20 U1 4 U2 29 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD SEP 16 PY 2014 VL 48 IS 18 BP 10531 EP 10538 DI 10.1021/es5016923 PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AP1BN UT WOS:000341801500002 PM 25121583 ER PT J AU Linkov, I Wood, M Bates, M AF Linkov, Igor Wood, Matthew Bates, Matthew TI Scientific Convergence: Dealing with the Elephant in the Room SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Editorial Material C1 [Linkov, Igor; Wood, Matthew; Bates, Matthew] US Army Engineer Res & Dev Ctr, Environm Lab, Concord, MA 01742 USA. RP Linkov, I (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, 696 Virginia Rd, Concord, MA 01742 USA. EM Igor.Linkov@usace.army.mil OI Wood, Matthew/0000-0002-1140-1526 NR 5 TC 1 Z9 1 U1 1 U2 11 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD SEP 16 PY 2014 VL 48 IS 18 BP 10539 EP 10540 DI 10.1021/es503585u PG 2 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AP1BN UT WOS:000341801500003 PM 25148594 ER PT J AU Hu, HT Eller, MA Zafar, S Zhou, Y Gu, MN Wei, Z Currier, JR Marovich, MA Kibuuka, HN Bailer, RT Koup, RA Robb, ML Michael, NL Kim, JH Ratto-Kim, S AF Hu, Haitao Eller, Michael A. Zafar, Shah Zhou, Yu Gu, Mengnan Wei, Zhi Currier, Jeffrey R. Marovich, Mary A. Kibuuka, Hannah N. Bailer, Robert T. Koup, Richard A. Robb, Merlin L. Michael, Nelson L. Kim, Jerome H. Ratto-Kim, Silvia TI Preferential infection of human Ad5-specific CD4 T cells by HIV in Ad5 naturally exposed and recombinant Ad5-HIV vaccinated individuals SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE AIDS; antigen-specific CD4 T cells; viral vectors ID ADENOVIRUS VACCINE; ENVELOPE PROTEIN; CCR5 LIGANDS; DOUBLE-BLIND; TRIAL; REPLICATION; RESPONSES; EFFICACY; STEP; SIV AB Efficacy trials of adenovirus 5-vectored candidate HIV vaccines [ recombinant Ad5 ( rAd5)-HIV] were halted for futility due to lack of vaccine efficacy and unexpected excess HIV infections in the vaccine recipients. The potential immunologic basis for these observations is unclear. We comparatively evaluated the HIV susceptibility and phenotypes of human CD4 T cells specific to Ad5 and CMV, two viruses that have been used as HIV vaccine vectors. We show that Ad5- specific CD4 T cells, either induced by natural Ad5 exposure or expanded by rAd5 vaccination, are highly susceptible to HIV in vitro and are preferentially lost in HIV-infected individuals compared with CMV-specific CD4 T cells. Further investigation demonstrated that Ad5- specific CD4 T cells selectively display a proinflammatory Th17-like phenotype and express macrophage inflammatory protein 3 alpha and alpha 4 beta 7 integrin, suggestive of gut mucosa homing potential of these cells. Analysis of HIV p24 and cytokine coexpression using flow cytometry revealed preferential infection of IL- 17- and IL-2-producing, Ad5-specific CD4 T cells by HIV in vitro. Our data suggest a potential mechanism explaining the excess HIV infections in vaccine recipients after rAd5-HIV vaccination and highlight the importance of testing the HIV susceptibility of vaccine-generated, vector and insert-specific CD4 T cells in future HIV vaccine studies. C1 [Hu, Haitao; Eller, Michael A.; Zafar, Shah; Robb, Merlin L.; Michael, Nelson L.; Kim, Jerome H.; Ratto-Kim, Silvia] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Currier, Jeffrey R.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD 20910 USA. [Hu, Haitao; Eller, Michael A.; Zafar, Shah; Robb, Merlin L.; Ratto-Kim, Silvia] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD 20817 USA. [Zhou, Yu] Temple Univ, Dept Pathol & Lab Med, Sch Med, Philadelphia, PA 19140 USA. [Gu, Mengnan; Wei, Zhi] New Jersey Inst Technol, Dept Comp Sci, Newark, NJ 07102 USA. [Marovich, Mary A.] NIAID, Div AIDS, NIH, Bethesda, MD 20817 USA. [Kibuuka, Hannah N.] Makerere Univ Walter Reed Project, Kampala, Uganda. [Bailer, Robert T.; Koup, Richard A.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. RP Hu, HT (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. EM hhu@hivresearch.org FU Robert Mapplethorpe Foundation HIV/AIDS grant; National Institutes of Health [1R21AI110214]; Henry M. Jackson Foundation [W81XWH-07-2-0067]; US Department of Defense [W81XWH-07-2-0067] FX We thank all the PBMC donors for their contributions to this study. The work was supported by a Robert Mapplethorpe Foundation HIV/AIDS grant (to H. H.), National Institutes of Health Grant 1R21AI110214 (to H. H.), and by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation and the US Department of Defense. NR 30 TC 13 Z9 15 U1 0 U2 3 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD SEP 16 PY 2014 VL 111 IS 37 BP 13439 EP 13444 DI 10.1073/pnas.1400446111 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AO8UH UT WOS:000341630000052 PM 25197078 ER PT J AU Hang, J Desai, V Zavaljevski, N Yang, Y Lin, XX Satya, RV Martinez, LJ Blaylock, JM Jarman, RG Thomas, SJ Kuschner, RA AF Hang, Jun Desai, Valmik Zavaljevski, Nela Yang, Yu Lin, Xiaoxu Satya, Ravi Vijaya Martinez, Luis J. Blaylock, Jason M. Jarman, Richard G. Thomas, Stephen J. Kuschner, Robert A. TI 16S rRNA gene pyrosequencing of reference and clinical samples and investigation of the temperature stability of microbiome profiles SO MICROBIOME LA English DT Article ID STORAGE-CONDITIONS; HUMAN-BODY; BACTERIAL COMMUNITIES; GUT MICROBIOME; DISEASE; CHALLENGES; AMPLICONS; OBESITY; DESIGN; TOOLS AB Background: Sample storage conditions, extraction methods, PCR primers, and parameters are major factors that affect metagenomics analysis based on microbial 16S rRNA gene sequencing. Most published studies were limited to the comparison of only one or two types of these factors. Systematic multi-factor explorations are needed to evaluate the conditions that may impact validity of a microbiome analysis. This study was aimed to improve methodological options to facilitate the best technical approaches in the design of a microbiome study. Three readily available mock bacterial community materials and two commercial extraction techniques, Qiagen DNeasy and MO BIO PowerSoil DNA purification methods, were used to assess procedures for 16S ribosomal DNA amplification and pyrosequencing-based analysis. Primers were chosen for 16S rDNA quantitative PCR and amplification of region V3 to V1. Swabs spiked with mock bacterial community cells and clinical oropharyngeal swabs were incubated at respective temperatures of -80 degrees C, -20 degrees C, 4 degrees C, and 37 degrees C for 4 weeks, then extracted with the two methods, and subjected to pyrosequencing and taxonomic and statistical analyses to investigate microbiome profile stability. Results: The bacterial compositions for the mock community DNA samples determined in this study were consistent with the projected levels and agreed with the literature. The quantitation accuracy of abundances for several genera was improved with changes made to the standard Human Microbiome Project (HMP) procedure. The data for the samples purified with DNeasy and PowerSoil methods were statistically distinct; however, both results were reproducible and in good agreement with each other. The temperature effect on storage stability was investigated by using mock community cells and showed that the microbial community profiles were altered with the increase in incubation temperature. However, this phenomenon was not detected when clinical oropharyngeal swabs were used in the experiment. Conclusions: Mock community materials originated from the HMP study are valuable controls in developing 16S metagenomics analysis procedures. Long-term exposure to a high temperature may introduce variation into analysis for oropharyngeal swabs, suggestive of storage at 4 degrees C or lower. The observed variations due to sample storage temperature are in a similar range as the intrapersonal variability among different clinical oropharyngeal swab samples. C1 [Hang, Jun; Yang, Yu; Lin, Xiaoxu; Martinez, Luis J.; Blaylock, Jason M.; Jarman, Richard G.; Thomas, Stephen J.; Kuschner, Robert A.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD 20910 USA. [Desai, Valmik; Zavaljevski, Nela; Satya, Ravi Vijaya] US Army Med Res & Mat Command, Dept Def Biotechnol High Performance, Telemed & Adv Technol Res Ctr, Comp Software Applicat Inst, Ft Detrick, MD 21702 USA. RP Hang, J (reprint author), Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD 20910 USA. EM jun.hang.ctr@mail.mil FU Military Infectious Diseases Research Program (MIDRP)/Defense Health Program enhancement (DHPe)/Defense Medical Research and Development Program (DMRDP) of the Department of Defense (DoD); Global Emerging Infections Surveillance and Response System (GEIS), a Division of the Armed Forces Health Surveillance Center FX This work was supported by the Military Infectious Diseases Research Program (MIDRP)/Defense Health Program enhancement (DHPe)/Defense Medical Research and Development Program (DMRDP) of the Department of Defense (DoD) and the Global Emerging Infections Surveillance and Response System (GEIS), a Division of the Armed Forces Health Surveillance Center. NR 53 TC 8 Z9 8 U1 2 U2 8 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 2049-2618 J9 MICROBIOME JI Microbiome PD SEP 16 PY 2014 VL 2 AR 31 DI 10.1186/2049-2618-2-31 PG 15 WC Microbiology SC Microbiology GA CU0HW UT WOS:000363197900001 PM 25228989 ER PT J AU Sweeney, LB Stewart, C Gaitonde, DY AF Sweeney, Lori B. Stewart, Christopher Gaitonde, David Y. TI Thyroiditis: An Integrated Approach SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID SUBACUTE THYROIDITIS; POSTPARTUM THYROIDITIS; INTERFERON-ALPHA; MANAGEMENT; THERAPY; HYPERTHYROIDISM; THYROTOXICOSIS; ABNORMALITIES; ASSOCIATION; HEPATITIS AB Thyroiditis is a general term that encompasses several clinical disorders characterized by inflammation of the thyroid gland. The most common is Hashimoto thyroiditis; patients typically present with a nontender goiter, hypothyroidism, and an elevated thyroid peroxidase antibody level. Treatment with levothyroxine ameliorates the hypothyroidism and may reduce goiter size. Postpartum thyroiditis is transient or persistent thyroid dysfunction that occurs within one year of childbirth, miscarriage, or medical abortion. Release of preformed thyroid hormone into the bloodstream may result in hyperthyroidism. This may be followed by transient or permanent hypothyroidism as a result of depletion of thyroid hormone stores and destruction of thyroid hormone producing cells. Patients should be monitored for changes in thyroid function. Beta blockers can treat symptoms in the initial hyperthyroid phase; in the subsequent hypothyroid phase, levothyroxine should be considered in women with a serum thyroid-stimulating hormone level greater than 10 mIU per L, or in women with a thyroid-stimulating hormone level of 4 to 10 mIU per L who are symptomatic or desire fertility. Subacute thyroiditis is a transient thyrotoxic state characterized by anterior neck pain, suppressed thyroid-stimulating hormone, and low radioactive iodine uptake on thyroid scanning. Many cases of subacute thyroiditis follow an upper respiratory viral illness, which is thought to trigger an inflammatory destruction of thyroid follicles. In most cases, the thyroid gland spontaneously resumes normal thyroid hormone production after several months. Treatment with high-dose acetylsalicylic acid or nonsteroidal anti-inflammatory drugs is directed toward relief of thyroid pain. (Copyright (C) 2014 American Academy of Family Physicians.) C1 [Sweeney, Lori B.] Virginia Commonwealth Univ Hlth Syst, Med, Richmond, VA USA. [Stewart, Christopher] Bayne Jones Army Community Hosp, Ft Polk, LA USA. [Gaitonde, David Y.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA. RP Sweeney, LB (reprint author), Virginia Commonwealth Univ, Med Coll Virginia, Dept Internal Med, Div Endocrinol & Metab, POB 980111, Richmond, VA 23298 USA. NR 26 TC 4 Z9 5 U1 1 U2 6 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X EI 1532-0650 J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD SEP 15 PY 2014 VL 90 IS 6 BP 389 EP 396 PG 8 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA AP3FK UT WOS:000341960800003 PM 25251231 ER PT J AU Sundermeyer, RL Persons, RK Carrillo, MJ AF Sundermeyer, Richard L. Persons, Robert K. Carrillo, Misty J. TI Prostaglandins to Induce Labor in Women with Asthma SO AMERICAN FAMILY PHYSICIAN LA English DT Editorial Material ID PREGNANCY C1 [Sundermeyer, Richard L.] John Peter Smith Family Med Residency, Ft Worth, TX 76104 USA. [Persons, Robert K.] Eglin Air Force Base Family Med Residency, Eglin AFB, FL USA. [Carrillo, Misty J.] Brooke Army Med Ctr, Joint Base San Antonio, Ft Sam Houston, TX 78234 USA. RP Sundermeyer, RL (reprint author), John Peter Smith Family Med Residency, Ft Worth, TX 76104 USA. EM jaydocsun@yahoo.com NR 5 TC 0 Z9 0 U1 0 U2 1 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X EI 1532-0650 J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD SEP 15 PY 2014 VL 90 IS 6 BP 415 EP 415 PG 1 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA AP3FK UT WOS:000341960800009 PM 25251237 ER PT J AU Schlader, ZJ Rivas, E Soller, BR Convertino, VA Crandall, CG AF Schlader, Zachary J. Rivas, Eric Soller, Babs R. Convertino, Victor A. Crandall, Craig G. TI Tissue oxygen saturation during hyperthermic progressive central hypovolemia SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY LA English DT Article DE lower body negative pressure; heat stress; simulated hemorrhage; syncope ID HUMAN SKELETAL-MUSCLE; COMBAT CASUALTY CARE; BLOOD-FLOW; ALPHA(1)-ADRENERGIC RESPONSIVENESS; EARLY INDICATOR; FEED ARTERIES; HEAT-STRESS; HUMAN LEG; HEMORRHAGE; DEATH AB During normothermia, a reduction in near-infrared spectroscopy (NIRS)-derived tissue oxygen saturation (SO2) is an indicator of central hypovolemia. Hyperthermia increases skin blood flow and reduces tolerance to central hypovolemia, both of which may alter the interpretation of tissue SO2 during central hypovolemia. This study tested the hypothesis that maximal reductions in tissue SO2 would be similar throughout normothermic and hyperthermic central hypovolemia to presyncope. Ten healthy males (means +/- SD; 32 +/- 5 yr) underwent central hypovolemia via progressive lower-body negative pressure (LBNP) to presyncope during normothermia (skin temperature approximate to 34 degrees C) and hyperthermia (+/- 1.2 +/- 0.1 degrees C increase in internal temperature via a water-perfused suit, skin temperature approximate to 39 degrees C). NIRS-derived forearm (flexor digitorum profundus) tissue SO2 was measured throughout and analyzed as the absolute change from pre-LBNP. Hyperthermia reduced (P < 0.001) LBNP tolerance by 49 +/- 33% (from 16.7 +/- 7.9 to 7.2 +/- 3.9 min). Pre-LBNP, tissue SO2 was similar (P = 0.654) between normothermia (74 +/- 5%) and hyperthermia (73 +/- 7%). Tissue SO2 decreased (P < 0.001) throughout LBNP, but the reduction from pre-LBNP to presyncope was greater during normothermia (-10 +/- 6%) than during hyperthermia (-6 +/- 5%; P = 0.041). Contrary to our hypothesis, these findings indicate that hyperthermia is associated with a smaller maximal reduction in tissue SO2 during central hypovolemia to presyncope. C1 [Schlader, Zachary J.; Rivas, Eric; Crandall, Craig G.] Texas Hlth Presbyterian Hosp, Inst Exercise & Environm Med, Dallas, TX 75231 USA. [Schlader, Zachary J.; Rivas, Eric; Crandall, Craig G.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA. [Rivas, Eric] Texas Womans Univ, Dept Kinesiol, Denton, TX 76204 USA. [Soller, Babs R.] Reflectance Med Inc, Westborough, MA USA. [Soller, Babs R.] Univ Massachusetts, Sch Med, Dept Anesthesiol, Worcester, MA USA. [Convertino, Victor A.] US Army, Inst Surg Res, Houston, TX USA. RP Crandall, CG (reprint author), Texas Hlth Presbyterian Hosp, Inst Exercise & Environm Med, 7232 Greenville Ave, Dallas, TX 75231 USA. EM CraigCrandall@texashealth.org OI Rivas, Eric/0000-0002-4657-8292 FU Department of Defense [W81XWH-12-1-0152]; National Institutes of Health [F32AG-04328, HL-61388] FX This study was supported by awards from the Department of Defense (W81XWH-12-1-0152) and National Institutes of Health (F32AG-04328; HL-61388). NR 22 TC 4 Z9 4 U1 0 U2 5 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0363-6119 EI 1522-1490 J9 AM J PHYSIOL-REG I JI Am. J. Physiol.-Regul. Integr. Comp. Physiol. PD SEP 15 PY 2014 VL 307 IS 6 BP R731 EP R736 DI 10.1152/ajpregu.00190.2014 PG 6 WC Physiology SC Physiology GA AO9TN UT WOS:000341700300016 PM 25031230 ER PT J AU Burgess, E AF Burgess, Edwin TI Thirteen Days in September: Carter, Begin, and Sadat at Camp David SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] US Army Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. RP Burgess, E (reprint author), US Army Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 2 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD SEP 15 PY 2014 VL 139 IS 15 BP 92 EP 93 PG 2 WC Information Science & Library Science SC Information Science & Library Science GA AO4ZT UT WOS:000341350600215 ER PT J AU Bell, JR AF Bell, Jocelyn R. TI An infinite game with topological consequences SO TOPOLOGY AND ITS APPLICATIONS LA English DT Article DE Topological game; W-space; Sigma-product ID NORMALITY; PRODUCTS AB We introduce a two player infinite game for which a winning strategy is preserved by Sigma-products and implies the existence of a winning strategy in Gruenhage's W-space game. A space exhibiting a winning strategy is collectionwise normal and countably paracompact. Consequently, a Sigma-product of spaces is collectionwise normal if each space possesses a winning strategy. This is a generalization of a well-known result on Sigma-products of metrizable spaces. Finally we show certain uniform box products have a winning strategy. Published by Elsevier B.V. C1 US Mil Acad, West Point, NY 10996 USA. RP Bell, JR (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 14 TC 3 Z9 3 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-8641 EI 1879-3207 J9 TOPOL APPL JI Topology Appl. PD SEP 15 PY 2014 VL 175 BP 1 EP 14 DI 10.1016/j.topol.2014.06.014 PG 14 WC Mathematics, Applied; Mathematics SC Mathematics GA AO0JO UT WOS:000340995100001 ER PT J AU Allison, PG Moser, RD Schirer, JP Martens, RL Jordon, JB Chandler, MQ AF Allison, P. G. Moser, R. D. Schirer, J. P. Martens, R. L. Jordon, J. B. Chandler, M. Q. TI In-situ nanomechanical studies of deformation and damage mechanisms in nanocomposites monitored using scanning electron microscopy SO MATERIALS LETTERS LA English DT Article DE Bending test; In-Situ testing; Nanocomposite; Nanoindentation; Scanning electron microscopy ID MONTMORILLONITE NANOCOMPOSITES; NACRE; INTERFACES; FRACTURE; MOTHER; PEARL; FILMS AB Novel diagnostic techniques incorporating focused ion beam (FIB) micro-milling, scanning electron microscopy (SEM), and in-situ SEM nanomechanical load frames performed micro-cantilever beam experiments on bio-inspired nanocomposites. Video of fracture behavior during the experiments correlated to load frame data indicated a hardening mechanism similar to the deformation mechanisms found in nacre. These methods developed for nanocomposites are applicable to a wide range of material systems for providing a unique understanding of deformation and failure mechanisms at lower length scales. Published by Elsevier B.V. C1 [Allison, P. G.; Moser, R. D.; Chandler, M. Q.] US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. [Schirer, J. P.] Hysitron Inc, Minneapolis, MN 55344 USA. [Martens, R. L.; Jordon, J. B.] Univ Alabama, Cent Analyt Facil, Tuscaloosa, AL 35487 USA. RP Allison, PG (reprint author), US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM paul.g.allison@usace.army.mil OI Allison, Paul/0000-0002-9041-237X FU Army Center Directed Research Program FX This work was funded by the Army Center Directed Research Program (US Army Engineer Research and Development Center, Dr. David Homer, Technical Director). Permission to publish granted by Director of the Geotechnical and Structures Laboratory. NR 19 TC 8 Z9 8 U1 4 U2 36 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-577X EI 1873-4979 J9 MATER LETT JI Mater. Lett. PD SEP 15 PY 2014 VL 131 BP 313 EP 316 DI 10.1016/j.matlet.2014.05.196 PG 4 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA AM8QJ UT WOS:000340141800087 ER PT J AU Fallowfield, JL Delves, SK Hill, NE Cobley, R Brown, P Lanham-New, SA Frost, G Brett, SJ Murphy, KG Montain, SJ Nicholson, C Stacey, M Ardley, C Shaw, A Bentley, C Wilson, DR Allsopp, AJ AF Fallowfield, Joanne L. Delves, Simon K. Hill, Neil E. Cobley, Rosalyn Brown, Pieter Lanham-New, Susan A. Frost, Gary Brett, Stephen J. Murphy, Kevin G. Montain, Scott J. Nicholson, Christopher Stacey, Michael Ardley, Christian Shaw, Anneliese Bentley, Conor Wilson, Duncan R. Allsopp, Adrian J. TI Energy expenditure, nutritional status, body composition and physical fitness of Royal Marines during a 6-month operational deployment in Afghanistan SO BRITISH JOURNAL OF NUTRITION LA English DT Article DE Nutrition; Military; Body composition; Energy expenditure ID ZINC; ANTIOXIDANT; SOLDIERS; HEALTH; LIMITS AB Understanding the nutritional demands on serving military personnel is critical to inform training schedules and dietary provision. Troops deployed to Afghanistan face austere living and working environments. Observations from the military and those reported in the British and US media indicated possible physical degradation of personnel deployed to Afghanistan. Therefore, the present study aimed to investigate the changes in body composition and nutritional status of military personnel deployed to Afghanistan and how these were related to physical fitness. In a cohort of British Royal Marines (n 249) deployed to Afghanistan for 6 months, body size and body composition were estimated from body mass, height, girth and skinfold measurements. Energy intake (EI) was estimated from food diaries and energy expenditure measured using the doubly labelled water method in a representative subgroup. Strength and aerobic fitness were assessed. The mean body mass of volunteers decreased over the first half of the deployment (-4.6 (SD 3.7) %), predominately reflecting fat loss. Body mass partially recovered ( mean +2.2 (SD 2.9) %) between the mid- and post-deployment periods (P<0.5). Daily EI (mean 10590 (SD 3339) kJ) was significantly lower than the estimated daily energy expenditure (mean 15167 (SD 1883) kJ) measured in a subgroup of volunteers. However, despite the body mass loss, aerobic fitness and strength were well maintained. Nutritional provision for British military personnel in Afghanistan appeared sufficient to maintain physical capability and micronutrient status, but providing appropriate nutrition in harsh operational environments must remain a priority. C1 [Fallowfield, Joanne L.; Delves, Simon K.; Cobley, Rosalyn; Brown, Pieter; Nicholson, Christopher; Shaw, Anneliese; Allsopp, Adrian J.] Inst Naval Med, Alverstoke PO12 2DL, Hants, England. [Hill, Neil E.; Stacey, Michael; Ardley, Christian; Wilson, Duncan R.] Royal Ctr Def Med, Birmingham, W Midlands, England. [Hill, Neil E.; Frost, Gary; Brett, Stephen J.; Murphy, Kevin G.] Univ London Imperial Coll Sci Technol & Med, London, England. [Lanham-New, Susan A.] Univ Surrey, Fac Hlth & Med Sci, Dept Nutr & Metab, Guildford GU2 5XH, Surrey, England. [Montain, Scott J.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. [Bentley, Conor] Univ Hosp Birmingham NHS Fdn Trust, Queen Elizabeth Hosp, Birmingham, W Midlands, England. RP Fallowfield, JL (reprint author), Inst Naval Med, Alverstoke PO12 2DL, Hants, England. EM joanne.fallowfield258@mod.uk FU United Kingdom Ministry of Defence; National Institute for Health Research (NIHR) Biomedical Research Centres based at Imperial College Healthcare NHS Trust and Imperial College London FX The present study was funded by the United Kingdom Ministry of Defence. Stable isotopes were provided by the US Army Research Institute of Environmental Medicine. Chemical analysis of the stable isotopes was carried out by the Pennington Biomedical Research Center, Baton Rouge, LA, USA. The study was supported by the National Institute for Health Research (NIHR) Biomedical Research Centres based at Imperial College Healthcare NHS Trust and Imperial College London (S. J. B., K. G. M. and G. F.). The views expressed are those of the authors and do not necessarily reflect those of the UK Government, the MOD, the NHS, the NIHR, or the Department of Health. NR 31 TC 4 Z9 4 U1 0 U2 14 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 0007-1145 EI 1475-2662 J9 BRIT J NUTR JI Br. J. Nutr. PD SEP 14 PY 2014 VL 112 IS 5 BP 821 EP 829 DI 10.1017/S0007114514001524 PG 9 WC Nutrition & Dietetics SC Nutrition & Dietetics GA AN9QD UT WOS:000340941500016 PM 25007417 ER PT J AU Bauschlicher, CW Haskins, JB Bucholz, EW Lawson, JW Borodin, O AF Bauschlicher, Charles W., Jr. Haskins, Justin B. Bucholz, Eric W. Lawson, John W. Borodin, Oleg TI Structure and Energetics of Li+-(BF4-)(n ') Li+-(FSI-)(n '), and Li+-(TFSI-)(n): Ab Initio and Polarizable Force Field Approaches SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID MOLECULAR-DYNAMICS SIMULATIONS; MAIN-GROUP THERMOCHEMISTRY; GAUSSIAN-BASIS SETS; NONCOVALENT INTERACTIONS; IONIC LIQUIDS; ELECTRON CORRELATION; LITHIUM BATTERIES; EXCHANGE; KINETICS; APPROXIMATION AB The Li+-BF4- and BF4--BF4- interactions are studied using second order perturbation theory (MP2) and coupled cluster singles and doubles approach, including the effect of connected triples, CCSD(T). The MP2 and CCSD(T) results are in excellent agreement. Using only the MP2 approach, the interactions of Li+ with bis(trifluoromethane)sulfonimide anion (TFSI) and Li+ with bis(fluorosulfonyl)imide anion (FSI) are studied. The results of these high level calculations are compared with density functional theory (DFT) calculations for a variety of functionals and with the APPLE&P force field. The B3LYP approach well reproduces the accurate calculations using both a small and large basis set. The M06 and M06L functionals in the larger basis set are in good agreement with the high level calculations. While the APPLE&P force field does not outperform the best functionals, the APPLE&P results agree better with the accurate results than do some of the functionals tested. C1 [Bauschlicher, Charles W., Jr.; Haskins, Justin B.; Bucholz, Eric W.; Lawson, John W.; Borodin, Oleg] NASA, Ames Res Ctr, Moffett Field, CA 94035 USA. [Borodin, Oleg] US Army Res Lab, Sensor & Electron Devices Directorate, Electrochem Branch, Adelphi, MD 20783 USA. EM Charles.W.Bauschlicher@nasa.gov RI Borodin, Oleg/B-6855-2012 OI Borodin, Oleg/0000-0002-9428-5291 FU NASA Aeronautics Research Institute Seedling program FX This work was supported by funding from the NASA Aeronautics Research Institute Seedling program. NR 31 TC 9 Z9 9 U1 3 U2 30 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1520-6106 J9 J PHYS CHEM B JI J. Phys. Chem. B PD SEP 11 PY 2014 VL 118 IS 36 BP 10785 EP 10794 DI 10.1021/jp506422p PG 10 WC Chemistry, Physical SC Chemistry GA AO8QP UT WOS:000341619600024 PM 25180695 ER PT J AU Sedegah, M Hollingdale, MR Farooq, F Ganeshan, H Belmonte, M Kim, Y Peters, B Sette, A Huang, J McGrath, S Abot, E Limbach, K Shi, M Soisson, L Diggs, C Chuang, I Tamminga, C Epstein, JE Villasante, E Richie, TL AF Sedegah, Martha Hollingdale, Michael R. Farooq, Fouzia Ganeshan, Harini Belmonte, Maria Kim, Yohan Peters, Bjoern Sette, Alessandro Huang, Jun McGrath, Shannon Abot, Esteban Limbach, Keith Shi, Meng Soisson, Lorraine Diggs, Carter Chuang, Ilin Tamminga, Cindy Epstein, Judith E. Villasante, Eileen Richie, Thomas L. TI Sterile Immunity to Malaria after DNA Prime/Adenovirus Boost Immunization Is Associated with Effector Memory CD8+T Cells Targeting AMA1 Class I Epitopes SO PLOS ONE LA English DT Article ID CD8(+) T-CELLS; APICAL MEMBRANE ANTIGEN-1; VACCINIA VIRUS ANKARA; CIRCUMSPOROZOITE PROTEIN; SPOROZOITE VACCINE; HEALTHY-ADULTS; NAIVE ADULTS; LIVER STAGES; RESPONSES; IMMUNOGENICITY AB Background: Fifteen volunteers were immunized with three doses of plasmid DNA encoding P. falciparum circumsporozoite protein (CSP) and apical membrane antigen-1 (AMA1) and boosted with human adenovirus-5 (Ad) expressing the same antigens (DNA/Ad). Four volunteers (27%) demonstrated sterile immunity to controlled human malaria infection and, overall, protection was statistically significantly associated with ELISpot and CD8+ T cell IFN-gamma activities to AMA1 but not CSP. DNA priming was required for protection, as 18 additional subjects immunized with Ad alone (AdCA) did not develop sterile protection. Methodology/Principal Findings: We sought to identify correlates of protection, recognizing that DNA-priming may induce different responses than AdCA alone. Among protected volunteers, two and three had higher ELISpot and CD8+ T cell IFN-gamma responses to CSP and AMA1, respectively, than non-protected volunteers. Unexpectedly, non-protected volunteers in the AdCA trial showed ELISpot and CD8+ T cell IFN-gamma responses to AMA1 equal to or higher than the protected volunteers. T cell functionality assessed by intracellular cytokine staining for IFN-gamma, TNF-alpha and IL-2 likewise did not distinguish protected from non-protected volunteers across both trials. However, three of the four protected volunteers showed higher effector to central memory CD8+ T cell ratios to AMA1, and one of these to CSP, than non-protected volunteers for both antigens. These responses were focused on discrete regions of CSP and AMA1. Class I epitopes restricted by A*03 or B*58 supertypes within these regions of AMA1 strongly recalled responses in three of four protected volunteers. We hypothesize that vaccine-induced effector memory CD8+ T cells recognizing a single class I epitope can confer sterile immunity to P. falciparum in humans. Conclusions/Significance: We suggest that better understanding of which epitopes within malaria antigens can confer sterile immunity and design of vaccine approaches that elicit responses to these epitopes will increase the potency of next generation gene-based vaccines. C1 [Sedegah, Martha; Hollingdale, Michael R.; Farooq, Fouzia; Ganeshan, Harini; Belmonte, Maria; Huang, Jun; McGrath, Shannon; Abot, Esteban; Limbach, Keith; Chuang, Ilin; Tamminga, Cindy; Epstein, Judith E.; Villasante, Eileen; Richie, Thomas L.] Naval Med Res Ctr, US Mil Malaria Vaccine Program, Silver Spring, MD 20910 USA. [Kim, Yohan; Peters, Bjoern; Sette, Alessandro] La Jolla Inst Allergy & Immunol, La Jolla, CA USA. [Shi, Meng] Walter Reed Army Inst Res, Div Med Audio Visual Lib & Stat Serv, Silver Spring, MD USA. [Soisson, Lorraine; Diggs, Carter] USAID, Washington, DC USA. RP Sedegah, M (reprint author), Naval Med Res Ctr, US Mil Malaria Vaccine Program, Silver Spring, MD 20910 USA. EM Martha.Sedegah@med.navy.mil OI Richie, Thomas/0000-0002-2946-5456 FU USAID [GHA-P-00-03-00006-01, 936-3118]; Congressionally Directed Medical Research Program [W81XWH-05-2-0041]; Military Infectious Research Program [62787A 870 F 1432] FX This work was supported by USAID "Development of Adenovirus-Vectored Malaria Vaccines'' Grant # GHA-P-00-03-00006-01, Project Number 936-3118; and the Congressionally Directed Medical Research Program "Development of Recombinant Adenoviral-based Vaccines against Malaria'' Grant # W81XWH-05-2-0041. Website https://cdmrp.org; Military Infectious Research Program "Phase 1/2a clinical trials assessing the safety, tolerability, immunogenicity & protective efficacy of Ad5-CA, a two-antigen, adenovirus-vectored Plasmodium falciparum malaria vaccine, in healthy, malaria-naive adults work unit number 62787A 870 F 1432. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. NR 63 TC 24 Z9 24 U1 0 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD SEP 11 PY 2014 VL 9 IS 9 AR e106241 DI 10.1371/journal.pone.0106241 PG 19 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AP1UA UT WOS:000341855900008 PM 25211344 ER PT J AU Mayo, M Abdelzaher, A Perkins, EJ Ghosh, P AF Mayo, Michael Abdelzaher, Ahmed Perkins, Edward J. Ghosh, Preetam TI Top-level dynamics and the regulated gene response of feed-forward loop transcriptional motifs SO PHYSICAL REVIEW E LA English DT Article ID FOLD-CHANGE DETECTION; NETWORK MOTIFS; ESCHERICHIA-COLI; PERFORMANCE; EXPRESSION; GENERATION; CIRCUITS; SYSTEM; TIMES; CELL AB Feed-forward loops are hierarchical three-node transcriptional subnetworks, wherein a top-level protein regulates the activity of a target gene via two paths: a direct-regulatory path, and an indirect route, whereby the top-level proteins act implicitly through an intermediate transcription factor. Using a transcriptional network of the model bacterium Escherichia coli, we confirmed that nearly all types of feed-forward loop were significantly overrepresented in the bacterial network. We then used mathematical modeling to study their dynamics by manipulating the rise times of the top-level protein concentration, termed the induction time, through alteration of the protein destruction rates. Rise times of the regulated proteins exhibited two qualitatively different regimes, depending on whether top-level inductions were "fast" or "slow." In the fast regime, rise times were nearly independent of rapid top-level inductions, indicative of biological robustness, and occurred when RNA production rate-limits the protein yield. Alternatively, the protein rise times were dependent upon slower top-level inductions, greater than approximately one bacterial cell cycle. An equation is given for this crossover, which depends upon three parameters of the direct-regulatory path: transcriptional cooperation at the DNA-binding site, a protein-DNA dissociation constant, and the relative magnitude of the top-level protien concentration. C1 [Mayo, Michael; Perkins, Edward J.] US Army Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Abdelzaher, Ahmed; Ghosh, Preetam] Virginia Commonwealth Univ, Dept Comp Sci, Richmond, VA 23284 USA. RP Mayo, M (reprint author), US Army Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. EM Michael.L.Mayo@usace.army.mil FU US Army's Environmental Quality and Installations 6.1 Basic Research program FX We thank Ananthram Swami and Christopher Warner for insightful discussions throughout the course of this research. Funding was provided by the US Army's Environmental Quality and Installations 6.1 Basic Research program. Opinions, interpretations, conclusions, and recommendations are those of the author(s) and are not necessarily endorsed by the U.S. Army. NR 46 TC 0 Z9 0 U1 0 U2 2 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1539-3755 EI 1550-2376 J9 PHYS REV E JI Phys. Rev. E PD SEP 10 PY 2014 VL 90 IS 3 AR 032706 DI 10.1103/PhysRevE.90.032706 PG 12 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA AU4PG UT WOS:000345593100003 PM 25314472 ER PT J AU Koehler, JW Hall, AT Rolfe, PA Honko, AN Palacios, GF Fair, JN Muyembe, JJ Mulembekani, P Schoepp, RJ Adesokan, A Minogue, TD AF Koehler, Jeffrey W. Hall, Adrienne T. Rolfe, P. Alexander Honko, Anna N. Palacios, Gustavo F. Fair, Joseph N. Muyembe, Jean-Jacques Mulembekani, Prime Schoepp, Randal J. Adesokan, Adeyemi Minogue, Timothy D. TI Development and Evaluation of a Panel of Filovirus Sequence Capture Probes for Pathogen Detection by Next-Generation Sequencing SO PLOS ONE LA English DT Article ID MULTIPLEX; PCR; DIFFERENTIATION; ASSAYS; VIRUS AB A detailed understanding of the circulating pathogens in a particular geographic location aids in effectively utilizing targeted, rapid diagnostic assays, thus allowing for appropriate therapeutic and containment procedures. This is especially important in regions prevalent for highly pathogenic viruses co-circulating with other endemic pathogens such as the malaria parasite. The importance of biosurveillance is highlighted by the ongoing Ebola virus disease outbreak in West Africa. For example, a more comprehensive assessment of the regional pathogens could have identified the risk of a filovirus disease outbreak earlier and led to an improved diagnostic and response capacity in the region. In this context, being able to rapidly screen a single sample for multiple pathogens in a single tube reaction could improve both diagnostics as well as pathogen surveillance. Here, probes were designed to capture identifying filovirus sequence for the ebolaviruses Sudan, Ebola, Reston, Tai Forest, and Bundibugyo and the Marburg virus variants Musoke, Ci67, and Angola. These probes were combined into a single probe panel, and the captured filovirus sequence was successfully identified using the MiSeq next-generation sequencing platform. This panel was then used to identify the specific filovirus from nonhuman primates experimentally infected with Ebola virus as well as Bundibugyo virus in human sera samples from the Democratic Republic of the Congo, thus demonstrating the utility for pathogen detection using clinical samples. While not as sensitive and rapid as real-time PCR, this panel, along with incorporating additional sequence capture probe panels, could be used for broad pathogen screening and biosurveillance. C1 [Koehler, Jeffrey W.; Hall, Adrienne T.; Schoepp, Randal J.; Minogue, Timothy D.] US Army, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. [Rolfe, P. Alexander; Adesokan, Adeyemi] Pathogenica Inc, Boston, MA USA. [Honko, Anna N.] US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Palacios, Gustavo F.] US Army, Med Res Inst Infect Dis, Ctr Genom Sci, Ft Detrick, MD 21702 USA. [Fair, Joseph N.] Metabiota, San Francisco, CA USA. [Muyembe, Jean-Jacques] Inst Natl Rech Biomed, Kinshasa, DEM REP CONGO. [Mulembekani, Prime] Kinshasa Sch Publ Hlth, Kinshasa, DEM REP CONGO. RP Minogue, TD (reprint author), US Army, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. EM timothy.d.minogue.civ@mail.mil RI Palacios, Gustavo/I-7773-2015; OI Palacios, Gustavo/0000-0001-5062-1938; Honko, Anna/0000-0001-9165-148X FU Defense Threat Reduction Agency (DTRA) [CB3630, CB2999] FX This project was funded by the Defense Threat Reduction Agency (DTRA; http://dtra.mil) under grant numbers CB3630 and CB2999. Reference materials, including aliquots of diagnostic samples, were obtained through a collaboration with National Institute of Biomedical Research (French acronym INRB) in Kinshasa. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 19 TC 8 Z9 9 U1 0 U2 26 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD SEP 10 PY 2014 VL 9 IS 9 AR e107007 DI 10.1371/journal.pone.0107007 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AP4EP UT WOS:000342030300054 PM 25207553 ER PT J AU Sadler, BM Hoyos, S AF Sadler, Brian M. Hoyos, Sebastian TI Towards a Standard Mixed-Signal Parallel Processing Architecture for Miniature and Microrobotics SO JOURNAL OF RESEARCH OF THE NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY LA English DT Article DE analog-to-digital conversion; communications; control; mixed-signal architecture; mixed-signal processing; perception; robotics; sensing; signal processing ID TO-DIGITAL CONVERSION; FREQUENCY-DOMAIN; ANALOG VLSI; FRONT-END; RECEIVER; SYSTEMS; DESIGN; SENSOR; SYNCHRONIZATION; COMMUNICATION AB The conventional analog-to-digital conversion (ADC) and digital signal processing (DSP) architecture has led to major advances in miniature and micro-systems technology over the past several decades. The outlook for these systems is significantly enhanced by advances in sensing, signal processing, communications and control, and the combination of these technologies enables autonomous robotics on the miniature to micro scales. In this article we look at trends in the combination of analog and digital (mixed-signal) processing, and consider a generalized sampling architecture. Employing a parallel analog basis expansion of the input signal, this scalable approach is adaptable and reconfigurable, and is suitable for a large variety of current and future applications in networking, perception, cognition, and control. C1 [Sadler, Brian M.] Army Res Lab, Adelphi, MD 20783 USA. [Hoyos, Sebastian] Texas A&M Univ, Dept Elect & Comp Engn, College Stn, TX 77843 USA. RP Sadler, BM (reprint author), Army Res Lab, Adelphi, MD 20783 USA. EM brian.m.sadler6.civ@mail.mil; hoyos@ece.tamu.edu NR 61 TC 0 Z9 0 U1 2 U2 3 PU US GOVERNMENT PRINTING OFFICE PI WASHINGTON PA SUPERINTENDENT DOCUMENTS,, WASHINGTON, DC 20402-9325 USA SN 1044-677X J9 J RES NATL INST STAN JI J. Res. Natl. Inst. Stand. Technol. PD SEP 8 PY 2014 VL 119 BP 529 EP 539 DI 10.6028/jres.119.020 PG 11 WC Instruments & Instrumentation; Physics, Applied SC Instruments & Instrumentation; Physics GA CC5MQ UT WOS:000350403100001 PM 26601042 ER PT J AU Shreiber, D Cole, MW Enriquez, E Hirsch, SG Ngo, E Hubbard, C Ivill, M Chen, CL AF Shreiber, D. Cole, M. W. Enriquez, E. Hirsch, S. G. Ngo, E. Hubbard, C. Ivill, M. Chen, Chonglin TI Some unusual behavior of dielectric properties of SrTiO3 metal organic chemical vapor deposition grown thin films SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID PULSED-LASER-DEPOSITION; STRONTIUM-TITANATE; MICROSTRUCTURE; TEMPERATURE; CONSTANT; STRAIN; MOCVD AB SrTiO3 (STO) thin films were grown simultaneously via the metal organic chemical vapor deposition (MOCVD) technique on two different substrates: platinized sapphire and platinized TiO2/SiO2/Si. The thin films were analyzed for stoichiometry, crystallinity, surface roughness, and average grain size. Dielectric properties of the thin films such as dielectric constant, loss, and leakage current characteristics were measured and compared. We demonstrate that the MOCVD technique is an appropriate method for fabrication of STO thin films with excellent structural, microstructural, dielectric, and insulation properties. Comparative analysis of the films yielded an unexpected result that the thin film with a higher mismatch in thermal expansion coefficient between the substrate (Si) and the deposited STO film yielded a higher dielectric constant with respect to that of STO/sapphire. The dielectric loss for both films were similar (tan delta = 0.005 at 100 kHz), however, the leakage current for the film with a higher dielectric constant was three orders of magnitude higher. An explanation of these results is presented and discussed. (C) 2014 AIP Publishing LLC. C1 [Shreiber, D.; Cole, M. W.; Hirsch, S. G.; Ngo, E.; Hubbard, C.; Ivill, M.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Enriquez, E.; Chen, Chonglin] Univ Texas San Antonio, Dept Phys & Astron, San Antonio, TX 78249 USA. RP Cole, MW (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM melanie.w.cole.civ@mail.mil FU U.S. Department of Energy; ARL FX This research was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Lab administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and ARL. NR 35 TC 1 Z9 1 U1 3 U2 25 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD SEP 7 PY 2014 VL 116 IS 9 AR 094101 DI 10.1063/1.4894811 PG 6 WC Physics, Applied SC Physics GA AQ5EB UT WOS:000342827800045 ER PT J AU Singamaneni, SR Punugupati, S Prater, JT Hunte, F Narayan, J AF Singamaneni, Srinivasa Rao Punugupati, Sandhyarani Prater, John T. Hunte, Frank Narayan, Jagdish TI Ferroelectric and ferromagnetic properties in BaTiO3 thin films on Si (100) SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID X-RAY-DIFFRACTION; DIELECTRIC-PROPERTIES; VAPOR-DEPOSITION; EPITAXIAL-GROWTH; SILICON; INTEGRATION; TRANSITION; MEMORY AB In this paper, we report on the epitaxial integration of room temperature lead-free ferroelectric BaTiO3 thin (similar to 1050 nm) films on Si (100) substrates by pulsed laser deposition technique through a domain matching epitaxy paradigm. We employed MgO and TiN as buffer layers to create BaTiO3/SrRuO3/MgO/TiN/Si (100) heterostructures. C-axis oriented and cube-on-cube epitaxial BaTiO3 is formed on Si (100) as evidenced by the in-plane and out-of-plane x-ray diffraction, and transmission electron microscopy. X-ray photoemission spectroscopic measurements show that Ti is in 4(+) state. Polarization hysteresis measurements together with Raman spectroscopy and temperature-dependent x-ray diffraction confirm the room temperature ferroelectric nature of BaTiO3. Furthermore, laser irradiation of BaTiO3 thin film is found to induce ferromagnetic-like behavior but affects adversely the ferroelectric characteristics. Laser irradiation induced ferromagnetic properties seem to originate from the creation of oxygen vacancies, whereas the pristine BaTiO3 shows diamagnetic behavior, as expected. This work has opened up the route for the integration of room temperature lead-free ferroelectric functional oxides on a silicon platform. (C) 2014 AIP Publishing LLC. C1 [Singamaneni, Srinivasa Rao; Prater, John T.] Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. [Singamaneni, Srinivasa Rao; Punugupati, Sandhyarani; Prater, John T.; Hunte, Frank; Narayan, Jagdish] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. RP Singamaneni, SR (reprint author), Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. EM ssingam@ncsu.edu FU National Academy of Science (NAS), USA; Army Research Office [W911NF-04-D-0003]; State of North Carolina; National Science Foundation FX S.S.R. acknowledges National Academy of Science (NAS), USA, for awarding the NRC postdoctoral research associate fellowship. The authors are pleased to acknowledge the support of the Army Research Office under Grant W911NF-04-D-0003. We thank C. T. Shelton and J.-P. Maria for valuable help while depositing the top electrodes. We thank Dr. Jacob Jones and Jason Nikkel for their help in high temperature XRD measurements. Also, the authors acknowledge the use of the Analytical Instrumentation Facility (AIF) at North Carolina State University, which is supported by the State of North Carolina and the National Science Foundation. NR 25 TC 9 Z9 9 U1 6 U2 70 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD SEP 7 PY 2014 VL 116 IS 9 AR 094103 DI 10.1063/1.4894508 PG 5 WC Physics, Applied SC Physics GA AQ5EB UT WOS:000342827800047 ER PT J AU Thompson, T Wolfenstine, J Allen, JL Johannes, M Huq, A David, IN Sakamoto, J AF Thompson, Travis Wolfenstine, Jeff Allen, Jan L. Johannes, Michelle Huq, Ashfia David, Isabel N. Sakamoto, Jeff TI Tetragonal vs. cubic phase stability in Al - free Ta doped Li7La3Zr2O12 (LLZO) SO JOURNAL OF MATERIALS CHEMISTRY A LA English DT Article ID SOLID-ELECTROLYTE; ION CONDUCTIVITY; GARNET; CONDUCTORS; CRYSTAL AB Li7La3Zr2O12 (LLZO) garnet is attracting interest as a promising Li-ion solid electrolyte. LLZO exists in a tetragonal and cubic polymorph where the cubic phase exhibits similar to 2 orders of magnitude higher Li-ion conduction. It has been suggested that a critical Li vacancy concentration (0.4-0.5 atoms per formula unit) is required to stabilize the cubic polymorph of Li7La3Zr2O12. This has been confirmed experimentally for Al3+ doping on the Li+ site. Substitution of M5+ (M = Ta, Nb) for Zr4+ is an alternative means to create Li vacancies and should have the same critical Li vacancy concentration, nevertheless, subcritically doped compositions (0.25 moles of Li vacancies per formula unit) have been reported as cubic. Adventitious Al, from alumina crucibles, was likely present in these studies that could have acted as a second dopant to introduce vacancies. In this work, Al-free subcritically doped (Li6.75La3Zr1.75Ta0.25O12) and critically doped (Li6.5La3Zr1.5Ta0.5O12) compositions are investigated. X-ray diffraction indicates that both compositions are cubic. However, upon further materials characterization, including SEM analysis, Raman spectroscopy, Electrochemical Impedance Spectroscopy, and neutron diffraction it is evident that the subcritically doped composition is a mixture of cubic and tetragonal phases. The results of this study confirm that 0.4-0.5 Li vacancies per formula unit are required to stabilize the cubic polymorph of LLZO. C1 [Thompson, Travis; David, Isabel N.; Sakamoto, Jeff] Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA. [Wolfenstine, Jeff; Allen, Jan L.] RDRL SED C, Army Res Lab, Adelphi, MD 20783 USA. [Johannes, Michelle] Ctr Computat Mat Sci, Naval Res Lab, Anacostia, VA USA. [Huq, Ashfia] Oak Ridge Natl Lab, Spallat Neutron Source, Oak Ridge, TN USA. RP Sakamoto, J (reprint author), Michigan State Univ, Dept Chem Engn & Mat Sci, 2527 Michigan State Univ, E Lansing, MI 48824 USA. EM jsakamot@egr.msu.edu RI Huq, Ashfia/J-8772-2013 OI Huq, Ashfia/0000-0002-8445-9649 FU Revolutionary Materials for Solid State Energy Conversion, an Energy Frontier Research Center - US Department of Energy, Office of Science, Office of Basic Energy Science [DE SC001054]; U.S. Army Research Laboratory (ARL); Scientific User Facilities Division, Office of Basic Energy Sciences, U.S. Department of Energy FX TT and JS would like to acknowledge support from the Revolutionary Materials for Solid State Energy Conversion, an Energy Frontier Research Center funded by the US Department of Energy, Office of Science, Office of Basic Energy Science under Award Number DE SC001054. JW and JA would like to acknowledge support of the U.S. Army Research Laboratory (ARL). The diffraction Research conducted at the Spallation Neutron Source at Oak Ridge National Laboratory was sponsored by the Scientific User Facilities Division, Office of Basic Energy Sciences, U.S. Department of Energy. NR 23 TC 37 Z9 37 U1 24 U2 137 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2050-7488 EI 2050-7496 J9 J MATER CHEM A JI J. Mater. Chem. A PD SEP 7 PY 2014 VL 2 IS 33 BP 13431 EP 13436 DI 10.1039/c4ta02099e PG 6 WC Chemistry, Physical; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Energy & Fuels; Materials Science GA AN3UP UT WOS:000340514500031 ER PT J AU Khuntirat, B Yoon, IK Chittaganpitch, M Krueger, WS Supawat, K Blair, PJ Putnam, SD Gibbons, RV Buddhari, D Sawanpanyalert, P Heil, GL Friary, JA Gray, GC AF Khuntirat, Benjawan Yoon, In-Kyu Chittaganpitch, Malinee Krueger, Whitney S. Supawat, Krongkaew Blair, Patrick J. Putnam, Shannon D. Gibbons, Robert V. Buddhari, Darunee Sawanpanyalert, Pathom Heil, Gary L. Friary, John A. Gray, Gregory C. TI High Rate of A(H1N1)pdm09 Infections among Rural Thai Villagers, 2009-2010 SO PLOS ONE LA English DT Article ID A H1N1 VIRUS; APRIL-MAY 2009; NEW-YORK-CITY; INFLUENZA-A; PANDEMIC INFLUENZA; HOUSEHOLD TRANSMISSION; CLINICAL-DIAGNOSIS; SEASONAL INFLUENZA; OUTBREAK; ANTIBODY AB Background: Pandemic influenza A(H1N1)pdm09 emerged in Thailand in 2009. A prospective longitudinal adult cohort and household transmission study of influenza-like illness (ILI) was ongoing in rural Thailand at the time of emergence. Symptomatic and subclinical A(H1N1)pdm09 infection rates in the cohort and among household members were evaluated. Methods: A cohort of 800 Thai adults underwent active community-based surveillance for ILI from 2008-2010. Acute respiratory samples from ILI episodes were tested for A(H1N1)pdm09 by qRT-PCR; acute and 60-day convalescent blood samples were tested by A(H1N1)pdm09 hemagglutination inhibition assay (HI). Enrollment, 12-month and 24-month followup blood samples were tested for A(H1N1)pdm09 seroconversion by HI. Household members of influenza A-infected cohort subjects with ILI were enrolled in household transmission investigations in which day 0 and 60 blood samples and acute respiratory samples were tested by either qRT-PCR or HI for A(H1N1)pdm09. Seroconversion between annual blood samples without A(H1N1)pdm09-positive ILI was considered as subclinical infection. Results: The 2-yr cumulative incidence of A(H1N1)pdm09 infection in the cohort in 2009/2010 was 10.8% (84/781) with an annual incidence of 1.2% in 2009 and 9.7% in 2010; 83.3% of infections were subclinical (50% in 2009 and 85.9% in 2010). The 2-yr cumulative incidence was lowest (5%) in adults born <= 1957. The A(H1N1) pdm09 secondary attack rate among household contacts was 47.2% (17/36); 47.1% of these infections were subclinical. The highest A(H1N1)pdm09 secondary attack rate among household contacts (70.6%, 12/17) occurred among children born between 1990 and 2003. Conclusion: Subclinical A(H1N1)pdm09 infections in Thai adults occurred frequently and accounted for a greater proportion of all A(H1N1)pdm09 infections than previously estimated. The role of subclinical infections in A(H1N1)pdm09 transmission has important implications in formulating strategies to predict and prevent the spread of A(H1N1)pdm09 and other influenza virus strains. C1 [Khuntirat, Benjawan; Yoon, In-Kyu; Gibbons, Robert V.; Buddhari, Darunee] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Chittaganpitch, Malinee; Supawat, Krongkaew; Sawanpanyalert, Pathom] Minist Publ Hlth, Natl Inst Hlth, Nonthaburi, Thailand. [Krueger, Whitney S.; Heil, Gary L.; Friary, John A.; Gray, Gregory C.] Univ Florida, Coll Publ Hlth & Hlth Profess, Gainesville, FL USA. [Krueger, Whitney S.; Heil, Gary L.; Friary, John A.; Gray, Gregory C.] Univ Florida, Emerging Pathogens Inst, Gainesville, FL USA. [Blair, Patrick J.] Naval Med Res Ctr Asia, Singapore, Singapore. [Putnam, Shannon D.] Naval Hlth Res Ctr, San Diego, CA USA. RP Gray, GC (reprint author), Duke Univ, Sch Med, Duke Infect Dis, Durham, NC 27705 USA. EM gcgray2@gmail.com FU US Armed Forces Health Surveillance Center - Global Emerging Infections Surveillance and Response System; National Institute of Allergy and Infectious Diseases [R01 AI068803] FX This work was supported by the US Armed Forces Health Surveillance Center - Global Emerging Infections Surveillance and Response System (multiple grants to GCG, PJB, SDP, and IKY) and National Institute of Allergy and Infectious Diseases (R01 AI068803 to GCG). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 42 TC 0 Z9 0 U1 2 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD SEP 4 PY 2014 VL 9 IS 9 AR e106751 DI 10.1371/journal.pone.0106751 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AO3XV UT WOS:000341271500083 PM 25188434 ER PT J AU Pittman, PR Cavicchia, MA Kingsbury, JL Johnson, NA Barrera-Oro, JG Schmader, T Korman, L Quinn, X Ranadive, M AF Pittman, Phillip R. Cavicchia, M. A. Kingsbury, J. L. Johnson, N. A. Barrera-Oro, J. G. Schmader, T. Korman, L. Quinn, X. Ranadive, M. TI Anthrax vaccine adsorbed: Further evidence supporting continuing the vaccination series rather than restarting the series when doses are delayed SO VACCINE LA English DT Article DE Anthrax vaccine adsorbed; Biothrax (R); Protection against Bacillus anthracis; Human antibody response to Biothrax (R) ID PROTECTIVE ANTIGEN; ANTIBODY-RESPONSE; HUMANS; SAFETY; IMMUNOGENICITY; ROUTE; ASSAY; AVA AB Whether to restart or continue the series when anthrax vaccine doses are missed is a frequent medical management problem. We applied the noninferiority analysis model to this prospective study comparing the Bacillus anthracis protective antigen (PA) IgG antibody response and lethal toxin neutralization activity at day 28 to the anthrax vaccine adsorbed (AVA) (Biothrax (R)) administered on schedule or delayed. A total of 600 volunteers were enrolled: 354 in the on-schedule cohort; 246 in the delayed cohort. Differences were noted in immune responses between cohorts (p < 0.0001) and among the racial categories (p < 0.0001). Controlling for covariates, the delayed cohort was non-inferior to the on-schedule cohort for the rate of 4-fold rise in both anti-PA IgG concentration (p < 0.0001) and TNA ED50 titers (p < 0.0001); as well as the mean log(10)-transformed anti-PA IgG concentration (p < 0.0001) and the mean log10-transformed TNA ED50 titers (p < 0.0001). Providing a missed AVA dose after a delay as long as 5-7 years, elicits anti-PA IgG antibody and TNA ED50 responses that are robust and non-inferior to the responses observed when the 6-month dose is given on-schedule. These important data suggest it is not necessary to restart the series when doses of the anthrax vaccine are delayed as long as 5 or more years. Published by Elsevier Ltd. C1 [Pittman, Phillip R.; Korman, L.] US Army Med Res Inst Infect Dis, Dept Clin Res, Frederick, MD 21702 USA. [Cavicchia, M. A.; Kingsbury, J. L.] Womack Army Med Ctr, Dept Prevent Med, Ft Bragg, NC USA. [Johnson, N. A.] Womack Army Med Ctr, Dept Family Med, Ft Bragg, NC USA. [Barrera-Oro, J. G.; Schmader, T.; Quinn, X.; Ranadive, M.] Keaki Tech LLC, USAMRIID, Frederick, MD USA. RP Pittman, PR (reprint author), US Army Med Res Inst Infect Dis, Dept Clin Res, Frederick, MD 21702 USA. EM phillip.r.pittman.civ@mail.mil FU Military Vaccine Agency FX The opinions, interpretations, conclusions and recommendations expressed in the report are those of the authors and do not reflect the official position or opinion of the U.S. Department of Defense, the U.S. Department of the Army or any affiliated organization listed. The research described herein was sponsored by the Military Vaccine Agency. NR 23 TC 3 Z9 3 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD SEP 3 PY 2014 VL 32 IS 39 BP 5131 EP 5139 DI 10.1016/j.vaccine.2014.03.076 PG 9 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA AO7UY UT WOS:000341559300034 PM 24837771 ER PT J AU Hammond, RT AF Hammond, Richard T. TI Spin flip probability of electron due to torsional wave SO PHYSICAL REVIEW D LA English DT Article ID MAGNETIC-FIELD; GRAVITY; SEARCH AB The probability of spin flip of an electron due to a torsional wave is calculated. It is compared to the electromagnetic case, and ways to detect torsion are discussed. C1 [Hammond, Richard T.] Univ N Carolina, Dept Phys, Chapel Hill, NC 27599 USA. [Hammond, Richard T.] Army Res Off, Res Triangle Pk, NC 27703 USA. RP Hammond, RT (reprint author), Univ N Carolina, Dept Phys, Chapel Hill, NC 27599 USA. EM rhammond@email.unc.edu NR 16 TC 0 Z9 0 U1 0 U2 2 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2470-0010 EI 2470-0029 J9 PHYS REV D JI Phys. Rev. D PD SEP 3 PY 2014 VL 90 IS 6 AR 067501 DI 10.1103/PhysRevD.90.067501 PG 5 WC Astronomy & Astrophysics; Physics, Particles & Fields SC Astronomy & Astrophysics; Physics GA AO3WY UT WOS:000341269200013 ER PT J AU Sviatenko, L Kinney, C Gorb, L Hill, FC Bednar, AJ Okovytyy, S Leszczynski, J AF Sviatenko, Liudmyla Kinney, Chad Gorb, Leonid Hill, Frances C. Bednar, Anthony J. Okovytyy, Sergiy Leszczynski, Jerzy TI Comprehensive Investigations of Kinetics of Alkaline Hydrolysis of TNT (2,4,6-Trinitrotoluene), DNT (2,4-Dinitrotoluene), and DNAN (2,4-Dinitroanisole) SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID HIGHLY CONTAMINATED SOILS; DENSITY FUNCTIONALS; TRINITROTOLUENE; APPLICABILITY AB Combined experimental and computational techniques were used to analyze multistep chemical reactions in the alkaline hydrolysis of three nitroaromatic compounds: 2,4,6-trinitrotoluene (TNT), 2,4-dinitrotoluene (DNT), and 2,4-dinitroanisole (DNAN). The study reveals common features and differences in the kinetic behavior of these compounds. The analysis of the predicted pathways includes modeling of the reactions, along with simulation of UV-vis spectra, experimental monitoring of reactions using LC/MS techniques, development of the kinetic model by designing and solving the system of differential equations, and obtaining computationally predicted kinetics for decay and accumulation of reactants and products. Obtained results suggest that DNT and DNAN are more resistant to alkaline hydrolysis than TNT. The direct substitution of a nitro group by a hydroxide represents the most favorable pathway for all considered compounds. The formation of Meisenheimer complexes leads to the kinetic first-step intermediates in the hydrolysis of TNT. Janovsky complexes can also be formed during hydrolysis of TNT and DNT but in small quantities. Methyl group abstraction is one of the suggested pathways of DNAN transformation during alkaline hydrolysis. C1 [Sviatenko, Liudmyla; Leszczynski, Jerzy] Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA. [Sviatenko, Liudmyla] Kirovohrad Volodymyr Vynnychenko State Pedag Univ, UA-25006 Kirovohrad, Ukraine. [Kinney, Chad] Colorado State Univ, Pueblo, CO 81001 USA. [Gorb, Leonid] Badger Tech Serv Inc, San Antonio, TX 78216 USA. [Hill, Frances C.; Bednar, Anthony J.] US Army ERDC, Vicksburg, MS 39180 USA. [Okovytyy, Sergiy] Oles Honchar Dnipropetrovsk Natl Univ, Dept Organ Chem, UA-49000 Dnepropetrovsk, Ukraine. RP Leszczynski, J (reprint author), Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Ctr Nanotox, 1325 JR Lynch St,POB 17910, Jackson, MS 39217 USA. EM jerzy@icnanotox.org RI Okovytyy, Sergiy/F-9838-2010 OI Okovytyy, Sergiy/0000-0003-4367-1309 FU ERDC [W912HZ-13-P-0037]; National Science Foundation [OCI-1053575]; XSEDE award [DMR110088] FX We thank ERDC for financial support (grant number is W912HZ-13-P-0037). The computation time was provided by the Extreme Science and Engineering Discovery Environment (XSEDE) by National Science Foundation Grant Number OCI-1053575 and XSEDE award allocation Number DMR110088 and by the Mississippi Center for Supercomputer Research. NR 34 TC 7 Z9 7 U1 4 U2 41 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD SEP 2 PY 2014 VL 48 IS 17 BP 10465 EP 10474 DI 10.1021/es5026678 PG 10 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AO3KY UT WOS:000341229300064 PM 25083594 ER PT J AU Costa, A Osborne, AR Resio, DT Alessio, S Chrivi, E Saggese, E Bellomo, K Long, CE AF Costa, Andrea Osborne, Alfred R. Resio, Donald T. Alessio, Silvia Chrivi, Elisabetta Saggese, Enrica Bellomo, Katinka Long, Chuck E. TI Soliton Turbulence in Shallow Water Ocean Surface Waves SO PHYSICAL REVIEW LETTERS LA English DT Article ID KORTEWEG-DEVRIES EQUATION; GRAVITY; FLUID AB We analyze shallow water wind waves in Currituck Sound, North Carolina and experimentally confirm, for the first time, the presence of soliton turbulence in ocean waves. Soliton turbulence is an exotic form of nonlinear wave motion where low frequency energy may also be viewed as a dense soliton gas, described theoretically by the soliton limit of the Korteweg-deVries equation, a completely integrable soliton system: Hence the phrase "soliton turbulence" is synonymous with "integrable soliton turbulence." For periodic-quasiperiodic boundary conditions the ergodic solutions of Korteweg-deVries are exactly solvable by finite gap theory (FGT), the basis of our data analysis. We find that large amplitude measured wave trains near the energetic peak of a storm have low frequency power spectra that behave as similar to omega(-1). We use the linear Fourier transform to estimate this power law from the power spectrum and to filter densely packed soliton wave trains from the data. We apply FGT to determine the soliton spectrum and find that the low frequency similar to omega(-1) region is soliton dominated. The solitons have random FGT phases, a soliton random phase approximation, which supports our interpretation of the data as soliton turbulence. From the probability density of the solitons we are able to demonstrate that the solitons are dense in time and highly non-Gaussian. C1 [Costa, Andrea] Aix Marseille Univ, CNRS INSU, IRD, MIO,UM 110, F-13288 Marseille 9, France. [Costa, Andrea] Univ Toulon & Var, CNRS INSU, IRD, MIO,UM 110, F-83957 La Garde, France. [Osborne, Alfred R.] Nonlinear Waves Res Corp, Arlington, VA 22203 USA. [Resio, Donald T.] Univ N Florida, Dept Ocean Engn, Jacksonville, FL 32224 USA. [Alessio, Silvia; Chrivi, Elisabetta] Univ Turin, Dipartimento Fis, I-10125 Turin, Italy. [Saggese, Enrica] Univ Nice Sophia Antipolis, LPMC, UMR 7336, F-06100 Nice, France. [Bellomo, Katinka] Univ Miami, Rosenstiel Sch Marine & Atmospher Sci, Miami, FL 33149 USA. [Long, Chuck E.] US Army Engineer Res & Dev Ctr, Vicksburg, MS USA. RP Osborne, AR (reprint author), Nonlinear Waves Res Corp, Arlington, VA 22203 USA. EM andrea.costa@univ-amu.fr; al.osborne@gmail.com FU Army Corp of Engineers; Office of Naval Research FX We acknowledge partial support from the Army Corp of Engineers and the Office of Naval Research. NR 19 TC 11 Z9 11 U1 3 U2 24 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 EI 1079-7114 J9 PHYS REV LETT JI Phys. Rev. Lett. PD SEP 2 PY 2014 VL 113 IS 10 AR 108501 DI 10.1103/PhysRevLett.113.108501 PG 5 WC Physics, Multidisciplinary SC Physics GA AO3QH UT WOS:000341248100012 PM 25238388 ER PT J AU Darlington, D Wu, X Cap, AP AF Darlington, D. Wu, X. Cap, A. P. TI Polytrauma and Hemorrhage Affects Platelet Function in Rats SO TRANSFUSION LA English DT Meeting Abstract CT AABB Annual Meeting CY OCT 25-28, 2014 CL Philadelphia, PA SP AABB C1 [Darlington, D.; Wu, X.; Cap, A. P.] US Army Inst Surg Res, JBSA FT Sam Houston, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD SEP PY 2014 VL 54 SU 2 SI SI MA S9-010B BP 20A EP 21A PG 2 WC Hematology SC Hematology GA CB9PX UT WOS:000349965300016 ER PT J AU Meledeo, MA Campbell, J Rodriguez, A Valenciana, M Cap, AP AF Meledeo, M. A. Campbell, J. Rodriguez, A. Valenciana, M. Cap, A. P. TI Effects of Magnesium Sulfate Supplementation on the Response of Cold-Stored Platelets to Aggregation and Coagulation Stimuli Over Eight Days SO TRANSFUSION LA English DT Meeting Abstract CT AABB Annual Meeting CY OCT 25-28, 2014 CL Philadelphia, PA SP AABB C1 [Meledeo, M. A.; Campbell, J.; Rodriguez, A.; Valenciana, M.; Cap, A. P.] US Army Inst Surg Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD SEP PY 2014 VL 54 SU 2 SI SI MA SP117 BP 103A EP 103A PG 1 WC Hematology SC Hematology GA CB9PX UT WOS:000349965300210 ER PT J AU Bynum, J Getz, T Cap, AP Pidcoke, HF AF Bynum, J. Getz, T. Cap, A. P. Pidcoke, H. F. TI 4 degrees C Platelet Storage Reduces Reactive Oxygen Species, Preserves Mitochondrial Function, and Reduces Fibrinolysis SO TRANSFUSION LA English DT Meeting Abstract CT AABB Annual Meeting CY OCT 25-28, 2014 CL Philadelphia, PA SP AABB C1 [Bynum, J.; Getz, T.; Cap, A. P.; Pidcoke, H. F.] US Army, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD SEP PY 2014 VL 54 SU 2 SI SI MA SP120 BP 104A EP 104A PG 1 WC Hematology SC Hematology GA CB9PX UT WOS:000349965300213 ER PT J AU Getz, T Cap, AP AF Getz, T. Cap, A. P. TI Storage of Platelets at 4 degrees C in Platelet Additive Solutions Prevents Aggregate Formation and Preserves Platelet Functional Responses SO TRANSFUSION LA English DT Meeting Abstract CT AABB Annual Meeting CY OCT 25-28, 2014 CL Philadelphia, PA SP AABB C1 [Getz, T.; Cap, A. P.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX USA. NR 0 TC 1 Z9 1 U1 1 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD SEP PY 2014 VL 54 SU 2 SI SI MA SP121 BP 104A EP 104A PG 1 WC Hematology SC Hematology GA CB9PX UT WOS:000349965300214 ER PT J AU Pidcoke, HF Herzig, MC Shaffer, BS Fedyk, CG Chung, KK Cap, AP AF Pidcoke, H. F. Herzig, M. C. Shaffer, B. S. Fedyk, C. G. Chung, K. K. Cap, A. P. TI Blood Product Resuscitation is not Hemostatic in Trauma Patients Undergoing Surgical Debridement SO TRANSFUSION LA English DT Meeting Abstract CT AABB Annual Meeting CY OCT 25-28, 2014 CL Philadelphia, PA SP AABB C1 [Pidcoke, H. F.; Herzig, M. C.; Shaffer, B. S.; Fedyk, C. G.; Cap, A. P.] US Army Inst Surg Res, San Antonio, TX USA. [Chung, K. K.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD SEP PY 2014 VL 54 SU 2 SI SI MA SP337 BP 191A EP 191A PG 1 WC Hematology SC Hematology GA CB9PX UT WOS:000349965300429 ER PT J AU Gonzales, R Cap, AP Macdonald, VW Terry, T Royster, KA Mendes, A Martinaud, C Kane, S Benson, PJ Sailliol, A AF Gonzales, R. Cap, A. P. Macdonald, V. W. Terry, T. Royster, K. A. Mendes, A. Martinaud, C. Kane, S. Benson, P. J. Sailliol, A. TI Technical, Logistical, and Administrative Considerations in a Joint Manufacturing Process: Freeze-Dried Plasma SO TRANSFUSION LA English DT Meeting Abstract CT AABB Annual Meeting CY OCT 25-28, 2014 CL Philadelphia, PA SP AABB C1 [Macdonald, V. W.] US Army Med Mat Dev Act, Ft Detrick, MD USA. [Cap, A. P.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Kane, S.; Benson, P. J.] US Army Special Operat Command, Ft Bragg, NC USA. [Gonzales, R.] US Army Med Command, US Army Blood Program, Ft Sam Houston, TX USA. [Mendes, A.; Martinaud, C.; Sailliol, A.] Ctr Transfus Sanguine Armees, Paris, France. [Terry, T.; Royster, K. A.] Womack Army Med Ctr, Blood Donor Ctr, Ft Bragg, NC USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD SEP PY 2014 VL 54 SU 2 SI SI MA A24-030E BP 235A EP 235A PG 1 WC Hematology SC Hematology GA CB9PX UT WOS:000349965300538 ER PT J AU Makar, J Hamilton, LR Myers, TM AF Makar, J. Hamilton, L. R. Myers, T. M. TI EVALUATING AND APPRECIATING BEHAVIORAL TRAINING DIFFERENCES BETWEEN AFRICAN GREEN MONKEYS (CHLOROCEBUS AETHIOPS SABAEUS) AND CYNOMOLGUS MACAQUES (MACACA FASCICULARIS) SO AMERICAN JOURNAL OF PRIMATOLOGY LA English DT Meeting Abstract CT 37th Annual Meeting of the American-Society-of-Primatologists CY SEP 12-15, 2014 CL Decatur, GA SP Amer Soc Primatologists C1 [Hamilton, L. R.; Myers, T. M.] US Army Med Res Inst Chem Def, Neurobehav Toxicol Branch, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA. [Makar, J.] US Army Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0275-2565 EI 1098-2345 J9 AM J PRIMATOL JI Am. J. Primatol. PD SEP PY 2014 VL 76 SU 1 MA 138 BP 81 EP 81 PG 1 WC Zoology SC Zoology GA CB1GE UT WOS:000349374300136 ER PT J AU Abt, JP Sell, TC Lovalekar, MT Keenan, KA Bozich, AJ Morgan, JS Kane, SF Benson, PJ Lephart, SM AF Abt, John P. Sell, Timothy C. Lovalekar, Mita T. Keenan, Karen A. Bozich, Anthony J. Morgan, Jeffrey S. Kane, Shawn F. Benson, Peter J. Lephart, Scott M. TI Injury Epidemiology of US Army Special Operations Forces SO MILITARY MEDICINE LA English DT Article ID MUSCULOSKELETAL; PERSONNEL AB Musculoskeletal injuries have long been a problem in general purpose forces, yet anecdotal evidence provided by medical, human performance, and training leadership suggests musculoskeletal injuries are also a readiness impediment to Special Operations Forces (SOF). The purpose of this study was to describe the injury epidemiology of SOF utilizing self-reported injury histories. Data were collected on 106 SOF (age: 31.7 +/- 5.3 years, height: 179.0 +/- 5.5 cm, mass: 85.9 +/- 10.9 kg) for 1 year before the date of laboratory testing and filtered for total injuries and those with the potential to be preventable based on injury type, activity, and mechanism. The frequency of musculoskeletal injuries was 24.5 injuries per 100 subjects per year for total injuries and 18.9 injuries per 100 subjects per year for preventable injuries. The incidence of musculoskeletal injuries was 20.8 injured subjects per 100 subjects per year for total injuries and 16.0 injured subjects per 100 subjects per year for preventable injuries. Preventable musculoskeletal injuries comprised 76.9% of total injuries. Physical training (PT) was the most reported activity for total/preventable injuries (PT Command Organized: 46.2%/60.0%, PT Noncommand Organized: 7.7%/10.0%, PT Unknown: 3.8%/5.0%). Musculoskeletal injuries impede optimal physical readiness/tactical training in the SOF community. The data suggest a significant proportion of injuries are classified as preventable and may be mitigated with human performance programs. C1 [Abt, John P.; Sell, Timothy C.; Lovalekar, Mita T.; Keenan, Karen A.; Bozich, Anthony J.; Lephart, Scott M.] Univ Pittsburgh, Dept Sports Med & Nutr, Neuromuscular Res Lab, Pittsburgh, PA 15203 USA. [Morgan, Jeffrey S.; Kane, Shawn F.; Benson, Peter J.] US Army Special Operat Command AOMD, Ft Bragg, NC 28310 USA. RP Abt, JP (reprint author), Univ Pittsburgh, Dept Sports Med & Nutr, Neuromuscular Res Lab, 3830 South Water St, Pittsburgh, PA 15203 USA. FU U.S. Army Medical Research and Materiel Command [W81XWH-11-2-0020]; U.S. Army Research Laboratory [W911NF-10-1-0168] FX This study was funded by the U.S. Army Medical Research and Materiel Command (Award No. W81XWH-11-2-0020) and the U.S. Army Research Laboratory (Award No. W911NF-10-1-0168). NR 12 TC 9 Z9 9 U1 1 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD SEP PY 2014 VL 179 IS 10 BP 1106 EP 1112 DI 10.7205/MILMED-D-14-00078 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA CA7LH UT WOS:000349098300010 PM 25269128 ER PT J AU Mulvaney, SW Lynch, JH Hickey, MJ Rahman-Rawlins, T Schroeder, M Kane, S Lipov, E AF Mulvaney, Sean W. Lynch, James H. Hickey, Matthew J. Rahman-Rawlins, Tabassum Schroeder, Matthew Kane, Shawn Lipov, Eugene TI Stellate Ganglion Block Used to Treat Symptoms Associated With Combat-Related Post-Traumatic Stress Disorder: A Case Series of 166 Patients SO MILITARY MEDICINE LA English DT Article ID PSYCHOMETRIC PROPERTIES; OEF/OIF VETERANS; PTSD CHECKLIST; NERVOUS-SYSTEM; NGF; VULNERABILITY; DEPRESSION; DEATH AB Objective: Report the successful use of stellate ganglion blocks (SGBs) in 166 active duty service members with multiple combat deployments experiencing anxiety symptoms associated with post-traumatic stress disorder (PTSD). Background: Successful treatment of PTSD symptoms with SGB has been reported previously. This is the largest published case series evaluating SGB with a minimum of 3 months follow-up. Methods: Following clinical interview including administration of the PTSD Checklist (PCL), 166 service members with symptoms of PTSD elected to receive a SGB. All patients received a SGB on the right side at the level of the sixth cervical vertebrae (C6). The PCL was administered the day before treatment to establish a baseline, repeated 1 week later, and then monthly out to 3 months. A positive response was considered to be an improvement in the PCL score by 10 or greater points. Follow-up PCL scores from 3 to 6 months were obtained and analyzed for 166 patients. Results: In a military population with multiple combat deployments, over 70% of the patients treated had a clinically significant improvement in their PCL score which persisted beyond 3 to 6 months postprocedure. Conclusion: Selective blockade of the right cervical sympathetic chain at the C6 level is a safe and minimally invasive procedure that may provide durable relief from anxiety symptoms associated with PTSD. C1 [Mulvaney, Sean W.; Schroeder, Matthew] Uniformed Serv Univ Hlth Sci, Consortium Hlth & Mil Performance, Bethesda, MD 20814 USA. [Lynch, James H.] Stuttgart Army Hlth Clin, APO, AE 09751 USA. [Hickey, Matthew J.; Rahman-Rawlins, Tabassum] Naval Special Warfare Command, San Diego, CA 92155 USA. [Kane, Shawn] DCS Surgeon AOMD, USASOC A, Ft Bragg, NC 28310 USA. [Lipov, Eugene] Adv Pain Ctr, Hoffman Estates, IL 60169 USA. RP Mulvaney, SW (reprint author), Uniformed Serv Univ Hlth Sci, Consortium Hlth & Mil Performance, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. NR 43 TC 6 Z9 6 U1 2 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD SEP PY 2014 VL 179 IS 10 BP 1133 EP 1140 DI 10.7205/MILMED-D-14-00151 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA CA7LH UT WOS:000349098300014 PM 25269132 ER PT J AU Hill, SW AF Hill, Steven W. TI Effects of Canister Shot in the Civil War: Skull of a Soldier of the 54th Massachusetts Volunteers SO MILITARY MEDICINE LA English DT Editorial Material C1 US Army Med Res & Mat Command, Natl Museum Hlth & Med, Silver Spring, MD 20910 USA. RP Hill, SW (reprint author), US Army Med Res & Mat Command, Natl Museum Hlth & Med, 2500 Linden Lane, Silver Spring, MD 20910 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD SEP PY 2014 VL 179 IS 10 BP 1171 EP 1172 DI 10.7205/MILMED-D-14-00234 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA CA7LH UT WOS:000349098300019 PM 25269137 ER PT J AU Jeffery, DD Bulathsinhala, L Kroc, M Dorris, J AF Jeffery, Diana D. Bulathsinhala, Lakmini Kroc, Michelle Dorris, Joseph TI Prevalence, Health Care Utilization, and Costs of Fibromyalgia, Irritable Bowel, and Chronic Fatigue Syndromes in the Military Health System, 2006-2010 SO MILITARY MEDICINE LA English DT Article ID COMORBIDITIES; DISORDERS; VETERANS; CONSTIPATION; PREGABALIN; DIAGNOSIS; PATTERNS; PAIN AB Objective: We compared prevalence, health care utilization, and costs over time for nonelderly adults diagnosed with fibromyalgia syndrome (FMS), irritable bowel syndrome (IBS), and chronic fatigue syndrome (CFS) in relation to timing of federal approvals for FMS drugs. Data Source: We used military health care claims from October 2006 to September 2010. Study Design/Analysis: Retrospective, multiple-year comparisons were conducted using trend analyses, and time series regression-based generalized linear models. Results: Over 5 years, FMS prevalence rates increased from 0.307% to 0.522%, whereas IBS and CFS prevalence rates remained stable. The largest increase in FMS prevalence occurred between 2007 and 2008. Health care utilization was higher for FMS cases compared to IBS and CFS cases. Over 5 years, the total cost for FMS-related care increased $163.2 million, whereas IBS costs increased $14.9 million and CFS cost increased $3.7 million. Between 2006 and 2010, total pharmacy cost for FMS cases increased from $55 million ($3,641/person) to $96.3 million ($3,557/person). Conclusion: Although cause and effect cannot be established, the advent of federally approved drugs for FMS in concert with pharmaceutical industry marketing of these drugs coincide with the observed changes in prevalence, health care utilization, and costs of FMS relative to IBS and CFS. C1 [Jeffery, Diana D.] Def Hlth Agcy, Dept Def, Falls Church, VA 22042 USA. [Bulathsinhala, Lakmini] US Army Res Inst Environm Med, Natick, MA 01760 USA. [Kroc, Michelle] Altarum Inst, Alexandria, VA 22302 USA. [Dorris, Joseph] Altarum Inst, Ann Arbor, MI 48105 USA. RP Jeffery, DD (reprint author), Def Hlth Agcy, Dept Def, 7700 Arlington Blvd,Suite 5101, Falls Church, VA 22042 USA. NR 51 TC 6 Z9 6 U1 1 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD SEP PY 2014 VL 179 IS 9 BP 1021 EP 1029 DI 10.7205/MILMED-D-13-00419 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA CA7LF UT WOS:000349098100019 PM 25181721 ER PT J AU Clarke, T AF Clarke, Tim, Jr. TI Sickles' Leg and the Army Medical Museum SO MILITARY MEDICINE LA English DT Editorial Material C1 US Army Med Res & Mat Command, Natl Museum Hlth & Med, Silver Spring, MD 20910 USA. RP Clarke, T (reprint author), US Army Med Res & Mat Command, Natl Museum Hlth & Med, 2500 Linden Lane, Silver Spring, MD 20910 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD SEP PY 2014 VL 179 IS 9 BP 1051 EP 1051 DI 10.7205/MILMED-D-14-00182 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA CA7LF UT WOS:000349098100023 PM 25181725 ER PT J AU Newsome, J Nguyen, D AF Newsome, Jelaun Nguyen, Dana TI Cryptococcal Meningitis Caused by Cryptococcus neoformans in an Immunocompetent Soldier SO MILITARY MEDICINE LA English DT Article ID INFECTION; PATIENT; VARIETY; GATTII AB Background: Cryptococcus neoformans is an encapsulated yeast that commonly causes disease in individuals in the setting of immunocompromised states. It is rarely reported in immunocompetent patients in the literature. Highlight of a Report: An active duty service member with no significant medical history presented with persistent headache, nausea, vomiting, weight loss, and nocturnal fevers for 2 months. The patient was admitted to the hospital where a lumbar puncture was performed showing an elevated white blood cell count, low glucose, and elevated protein. Subsequent cerebral spinal fluid analysis yielded cryptococcal antigen latex screen and culture which speciated C. neoformans. The patient received fluconazole and flucytosine, and completed a 10-week course to result in a full recovery. Conclusion: C. neoformans is found throughout the world in soil contaminated with bird droppings and usually causes infection and disease in individuals who are immunosuppressed. Rare case reports exist where C. neoformans causes central nervous infection in immunocompetent hosts. This fungal etiology should be considered in all patients presenting with meningitis symptoms and a cerebral spinal fluid panel with low glucose and high protein, or without a clear bacterial etiology. This case illustrates the importance of broadening the differential when previously healthy service members present with common or nonspecific symptoms. C1 [Newsome, Jelaun; Nguyen, Dana] Womack Army Med Ctr, Dept Family Med, Ft Bragg, NC 28310 USA. RP Newsome, J (reprint author), Womack Army Med Ctr, Dept Family Med, 2817 Reilly Rd, Ft Bragg, NC 28310 USA. NR 18 TC 1 Z9 1 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD SEP PY 2014 VL 179 IS 9 BP E1059 EP E1061 DI 10.7205/MILMED-D-14-00020 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA CA7LF UT WOS:000349098100002 PM 25181727 ER PT J AU Sundaram, HS Han, X Nowinski, AK Brault, ND Li, YT Ella-Menye, JR Amoaka, KA Cook, KE Marek, P Senecal, K Jiang, SY AF Sundaram, Harihara S. Han, Xia Nowinski, Ann K. Brault, Norman D. Li, Yuting Ella-Menye, Jean-Rene Amoaka, Kagya A. Cook, Keith E. Marek, Patrick Senecal, Kris Jiang, Shaoyi TI Achieving One-Step Surface Coating of Highly Hydrophilic Poly(Carboxybetaine Methacrylate) Polymers on Hydrophobic and Hydrophilic Surfaces SO ADVANCED MATERIALS INTERFACES LA English DT Article ID SELF-ASSEMBLED MONOLAYERS; BIOMIMETIC ADHESIVE GROUP; MYTILUS-CALIFORNIANUS; ZWITTERIONIC POLYMER; PROTEIN ADSORPTION; COMPLEX MEDIA; FILMS; FUNCTIONALIZATION; CHEMISTRY; SULFOBETAINE AB It is highly desirable to develop a universal nonfouling coating via a simple one-step dip-coating method. Developing such a universal coating method for a hydrophilic polymer onto a variety of surfaces with hydrophobic and hydrophilic properties is very challenging. This work demonstrates a versatile and simple method to attach zwitterionic poly(carboxybetaine methacrylate) (PCB), one of the most hydrophilic polymers, onto both hydrophobic and hydrophilic surfaces to render them nonfouling. This is achieved by the coating of a catechol chain end carboxybetaine methacrylate polymer (DOPA-PCB) assisted by dopamine. The coating process was carried out in water. Water miscible solvents such as methanol and tetrahydrofuran (THF) are added to the coatings if surface wettability is an issue, as for certain hydrophobic surfaces. This versatile coating method was applied to several types of surfaces such as polypropylene (PP), polydimethyl siloxane (PDMS), Teflon, polystyrene (PS), polymethylmethacrylate (PMMA), polyvinyl chloride (PVC) and also on metal oxides such as silicon dioxide. C1 [Sundaram, Harihara S.; Nowinski, Ann K.; Brault, Norman D.; Ella-Menye, Jean-Rene; Jiang, Shaoyi] Univ Washington, Dept Chem Engn, Seattle, WA 98195 USA. [Han, Xia] E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China. [Han, Xia] E China Univ Sci & Technol, Dept Chem, Shanghai 200237, Peoples R China. [Amoaka, Kagya A.; Cook, Keith E.] Univ Michigan, Dept Surg, Ann Arbor, MI 48109 USA. [Marek, Patrick; Senecal, Kris] US Army, Natick Soldier Res Dev & Engn Ctr, Natick, MA USA. RP Jiang, SY (reprint author), Univ Washington, Dept Chem Engn, Box 351750, Seattle, WA 98195 USA. EM sjiang@uw.edu FU National Science Foundation [CMMI-1301435]; U.S. Army Natick Soldier Research, Development and Engineering Center; Defense Advanced Research Projects Agency [N66001-12-1-4263]; Office of Naval Research [N000141210441]; National Natural Science Foundation of China [21176065]; Shanghai Municipal Education Commission; NIH [NIH 5T32HL007853-15] FX This work was supported by the National Science Foundation (CMMI-1301435), the U.S. Army Natick Soldier Research, Development and Engineering Center, the Defense Advanced Research Projects Agency (N66001-12-1-4263) and the Office of Naval Research (N000141210441). XH acknowledges financial support from the National Natural Science Foundation of China (No. 21176065) and Shanghai Municipal Education Commission. KA acknowledges funding from the NIH (NIH 5T32HL007853-15). NR 50 TC 7 Z9 7 U1 22 U2 108 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2196-7350 J9 ADV MATER INTERFACES JI Adv. Mater. Interfaces PD SEP PY 2014 VL 1 IS 6 AR 1400071 DI 10.1002/admi.201400071 PG 8 WC Chemistry, Multidisciplinary; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA AZ5TZ UT WOS:000348284500003 ER PT J AU Armstrong, LE Johnson, EC Kunces, LJ Ganio, MS Judelson, DA Kupchak, BR Vingren, JL Munoz, CX Huggins, RA Hydren, JR Moyen, NE Williamson, KH AF Armstrong, Lawrence E. Johnson, Evan C. Kunces, Laura J. Ganio, Matthew S. Judelson, Daniel A. Kupchak, Brian R. Vingren, Jakob L. Munoz, Colleen X. Huggins, Robert A. Hydren, Jay R. Moyen, Nicole E. Williamson, Keith H. TI Drinking to Thirst Versus Drinking Ad Libitum During Road Cycling SO JOURNAL OF ATHLETIC TRAINING LA English DT Article DE rehydration; fluids; electrolytes; urine; sport nutrition ID THERMOREGULATORY RESPONSES; POSITION STATEMENT; PROLONGED EXERCISE; FLUID REPLACEMENT; HYDRATION STATUS; DEHYDRATION; RUNNERS; CONSUMPTION; COMPETITION; BEHAVIORS AB Context: The sensation of thirst is different from the complex behavior of drinking ad libitum. Rehydration recommendations to athletes differ, depending on the source, yet no previous researchers have systematically compared drinking to thirst (D-TT) versus ad libitum drinking behavior (D-AL). Objective: To compare 2 groups of trained cyclists (D-TT and D-AL) who had similar physical characteristics and training programs (P>.05). The D-TT group (n = 12, age = 47 +/- 7 years) drank only when thirsty, whereas the D-AL group (n = 12, age = 44 6 7 years) consumed fluid ad libitum (ie, whenever and in whatever volume desired). Design: Cohort study. Setting: Road cycling (164 km) in the heat (36.1 degrees C +/- 6.5 degrees C). Patients or Other Participants: Ultraendurance cyclists (4 women, 20 men). Intervention(s): We recorded measurements 1 day before the event, on event day before the start, at 3 roadside aid stations, at the finish line, and 1 day after the event. Main Outcome Measure(s): Body mass, urinary hydration indices, and food and fluids consumed. Results: No between-groups differences were seen on event day for total exercise time (D-TT = 6.69 +/- 0.89 hours, D-AL = 6.66 +/- 0.77 hours), urinary indices (specific gravity, color), body mass change (D-TT = -2.22% 6 1.73%, D-AL = -2.29% 6 1.62%), fluid intake (D-TT = 5.63 +/- 2.59 L/6.7 h, D-AL = 6.04 +/- 2.37 L/6.7 h), dietary energy intake, macronutrient intake, ratings of thirst (D-TT start = 2 6 1, D-TT finish = 6 +/- 1, D-AL start = 2 +/- 1, D-AL finish = 6 +/- 1), pain, perceived exertion, or thermal sensation. Total fluid intake on recovery day_1 was the primary significant difference (D-AL = 5.13 +/- 1.87 L/24 h, D-TT = 3.13 +/- 1.53 L/24 h, t(18) = 2.59, P = .02). Conclusions: Observations on event day indicated that drinking to thirst and drinking ad libitum resulted in similar physiologic and perceptual outcomes. This suggests that specific instructions to "drink to thirst" were unnecessary. Indeed, if athletes drink ad libitum, they can focus on training and competition rather than being distracted by ongoing evaluation of thirst sensations. C1 [Armstrong, Lawrence E.; Kunces, Laura J.; Kupchak, Brian R.; Munoz, Colleen X.; Huggins, Robert A.] Univ Connecticut, Storrs, CT USA. [Johnson, Evan C.; Ganio, Matthew S.; Hydren, Jay R.] Univ Arkansas, Fayetteville, AR 72701 USA. [Judelson, Daniel A.; Moyen, Nicole E.] Calif State Univ Fullerton, Fullerton, CA 92634 USA. [Vingren, Jakob L.] Univ N Texas, Denton, TX 76203 USA. US Army, Environm Med Res Inst, Natick, MA 01760 USA. [Williamson, Keith H.] Midwestern State Univ, Wichita Falls, TX 76308 USA. RP Armstrong, LE (reprint author), Univ Connecticut, Dept Kinesiol, Human Performance Lab, Unit 1110,2095 Hillside Rd, Storrs, CT 06269 USA. EM lawrence.armstrong@uconn.edu RI Kupchak, Brian/K-2527-2015; Hydren, Jay/H-3654-2016 OI Hydren, Jay/0000-0001-9385-8898 NR 35 TC 13 Z9 13 U1 4 U2 20 PU NATL ATHLETIC TRAINERS ASSOC INC PI DALLAS PA 2952 STEMMONS FREEWAY, DALLAS, TX 75247 USA SN 1062-6050 EI 1938-162X J9 J ATHL TRAINING JI J. Athl. Train. PD SEP-OCT PY 2014 VL 49 IS 5 BP 624 EP 631 DI 10.4085/1062-6050-49.3.85 PG 8 WC Sport Sciences SC Sport Sciences GA AY4NN UT WOS:000347555600008 PM 25098657 ER PT J AU Veith, GJ AF Veith, George J. TI The Pro-War Movement: Domestic Support for the Vietnam War and the Making of Modern American Conservatism SO JOURNAL OF COLD WAR STUDIES LA English DT Book Review C1 [Veith, George J.] US Army, Washington, DC 20301 USA. RP Veith, GJ (reprint author), US Army, Washington, DC 20301 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU MIT PRESS PI CAMBRIDGE PA ONE ROGERS ST, CAMBRIDGE, MA 02142-1209 USA SN 1520-3972 EI 1531-3298 J9 J COLD WAR STUD JI J. Cold War Stud. PD FAL PY 2014 VL 16 IS 4 BP 273 EP 275 PG 4 WC History; International Relations; Political Science SC History; International Relations; Government & Law GA CA1CT UT WOS:000348651400032 ER PT J AU Sokolow, A Scheidler, M AF Sokolow, Adam Scheidler, Mike TI NONUNIFORM SHEAR STRAINS IN TORSIONAL KOLSKY BAR TESTS ON SOFT SPECIMENS SO JOURNAL OF MECHANICS OF MATERIALS AND STRUCTURES LA English DT Article DE torsion; Kolsky bar; soft materials; incompressible; Mooney-Rivlin ID HUMAN BRAIN-TISSUE; ELASTIC SOLIDS; WAVES; INERTIA; BULK AB We investigate inertial effects in torsional Kolsky bar tests on nearly incompressible, soft materials. The results are relevant for materials with instantaneous elastic shear modulus on the order of 1-1000 kPa and density on the order of water. Examples include brain tissue and many other soft tissues and tissue surrogates. We have conducted one- and three-dimensional analyses and simulations to understand the stress and strain states that exist in these materials in a torsional Kolsky bar test. We demonstrate that the short loading pulses typically used for high strain-rate (e.g., 700/s) tests do not allow the softer specimens to "ring-up" to uniform stress and strain states and that consequently the shear stress versus shear strain data reported in the literature are erroneous. We also show that normal stress components, which are present even in quasistatic torsion of nonlinear elastic materials, can be amplified in dynamic torsion tests on soft materials. C1 [Sokolow, Adam; Scheidler, Mike] US Army Res Lab, Soldier Protect Sci Branch, Aberdeen Proving Ground, MD 21005 USA. RP Sokolow, A (reprint author), US Army Res Lab, Soldier Protect Sci Branch, Aberdeen Proving Ground, MD 21005 USA. EM adam.c.sokolow.civ@mail.mil; michael.j.scheidler2.ctr@mail.mil FU U.S. Department of Energy; ARL FX This research was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory (ARL) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and ARL. NR 39 TC 0 Z9 0 U1 2 U2 9 PU MATHEMATICAL SCIENCE PUBL PI BERKELEY PA UNIV CALIFORNIA, DEPT MATHEMATICS, BERKELEY, CA 94720-3840 USA SN 1559-3959 J9 J MECH MATER STRUCT JI J. Mech. Mater. Struct. PD SEP PY 2014 VL 9 IS 5 BP 515 EP 555 DI 10.2140/jomms.2014.9.515 PG 41 WC Materials Science, Multidisciplinary; Mechanics SC Materials Science; Mechanics GA AZ9GA UT WOS:000348520300004 ER PT J AU Haugh, JA AF Haugh, Jeremy A. TI BEYOND R2P: A PROPOSED TEST FOR LEGALIZING UNILATERAL ARMED HUMANITARIAN INTERVENTION SO MILITARY LAW REVIEW LA English DT Article ID JUS POST BELLUM; WAR C1 US Army, Washington, DC USA. RP Haugh, JA (reprint author), US Army, Washington, DC USA. NR 86 TC 0 Z9 0 U1 2 U2 3 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 2014 VL 221 BP 1 EP 74 PG 74 WC Law SC Government & Law GA AY6JH UT WOS:000347672200001 ER PT J AU Leary, RW AF Leary, Ryan W. TI SERIOUS OFFENSE: CONSIDERING THE SEVERITY OF THE CHARGED OFFENSE WHEN APPLYING THE MILITARY'S PRE-TRIAL CONFINEMENT RULES SO MILITARY LAW REVIEW LA English DT Article C1 US Army, Washington, DC USA. RP Leary, RW (reprint author), US Army, Washington, DC USA. NR 15 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 2014 VL 221 BP 131 EP 152 PG 22 WC Law SC Government & Law GA AY6JH UT WOS:000347672200003 ER PT J AU Kornegay, KD AF Kornegay, Kevin D. TI DESTROYING THE SHRINES OF UNBELIEVERS: THE CHALLENGE OF ICONOCLASM TO THE INTERNATIONAL FRAMEWORK FOR THE PROTECTION OF CULTURAL PROPERTY SO MILITARY LAW REVIEW LA English DT Article AB On the basis of consultations between the religious leaders of the Islamic Emirate of Afghanistan, religious judgments of the ulema and rulings of the Supreme Court of the Islamic Emirate of Afghanistan, all statues and non-Islamic shrines located in different parts of the Islamic Emirate of Afghanistan must be destroyed. These statues have been and remain shrines of unbelievers and these unbelievers continue to worship and respect them. God Almighty is the only real shrine and all fake idols must. be destroyed.(1) C1 US Army, Washington, DC USA. RP Kornegay, KD (reprint author), US Army, Washington, DC USA. NR 56 TC 0 Z9 0 U1 0 U2 1 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 2014 VL 221 BP 153 EP 182 PG 30 WC Law SC Government & Law GA AY6JH UT WOS:000347672200004 ER PT J AU Misnec, ML AF Misnec, Marcus L. TI GET BACK IN LINE: HOW MINOR REVISIONS TO AR 600-8-4 WOULD REJUVENATE SUICIDE LINE OF DUTY INVESTIGATIONS SO MILITARY LAW REVIEW LA English DT Article AB I hear you, judge. What he did disgusts me and if he was alive, I'd expect you to put him in jail for a long time. But i f I don't find him in the line of duty, then the family gets upset and it draws the attention of higher ups. If I do find him in the line of duty, nobody gives it a second thought.(1) C1 US Army, Washington, DC USA. RP Misnec, ML (reprint author), US Army, Washington, DC USA. NR 24 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 2014 VL 221 BP 183 EP 214 PG 32 WC Law SC Government & Law GA AY6JH UT WOS:000347672200005 ER PT J AU Stich, KK AF Stich, Katherine K. TI CUSTOMARY JUSTICE SYSTEMS AND RULE OF LAW REFORM SO MILITARY LAW REVIEW LA English DT Article C1 US Army, Washington, DC USA. RP Stich, KK (reprint author), US Army, Washington, DC USA. NR 39 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 2014 VL 221 BP 215 EP 256 PG 42 WC Law SC Government & Law GA AY6JH UT WOS:000347672200006 ER PT J AU Nef, AJ AF Nef, A. Jason TI 1493: UNCOVERING THE NEW WORLD COLUMBUS CREATED SO MILITARY LAW REVIEW LA English DT Book Review C1 US Army, Washington, DC USA. RP Nef, AJ (reprint author), US Army, Washington, DC USA. NR 4 TC 0 Z9 0 U1 1 U2 1 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 2014 VL 221 BP 309 EP 315 PG 7 WC Law SC Government & Law GA AY6JH UT WOS:000347672200010 ER PT J AU Harper, NG Esposito, ER Wilken, JM Neptune, RR AF Harper, Nicole G. Esposito, Elizabeth Russell Wilken, Jason M. Neptune, Richard R. TI The influence of ankle-foot orthosis stiffness on walking performance in individuals with lower-limb impairments SO CLINICAL BIOMECHANICS LA English DT Article DE Othosis; AFO; Walking; Biomechanics; Selective laser sintering; Stiffness ID JOINT COORDINATE SYSTEM; MUSCLE-ACTIVITY; KINEMATIC DATA; GAIT ANALYSIS; OIL DAMPER; SUPPORT; PROGRESSION; BODY; HEMIPLEGIA; CHILDREN AB Background: Passive-dynamic ankle-foot orthoses utilize stiffness to improve gait performance through elastic energy storage and return. However, the influence of ankle-foot orthosis stiffness on gait performance has not been systematically investigated, largely due to the difficulty of manufacturing devices with precisely controlled stiffness levels. Additive manufacturing techniques such as selective laser sintering have been used to successfully manufacture ankle-foot orthoses with controlled stiffness levels. The purpose of this study was to use passive-dynamic ankle-foot oithoses manufactured with selective laser sintering to identify the influence of orthosis stiffness on walking performance in patients with lower-limb neuromuscular and musculoskeletal impairments. Methods: Thirteen subjects with unilateral impairments were enrolled in this study. For each subject, one passive-dynamic ankle-foot orthosis with stiffness equivalent to the subject's clinically prescribed carbon fiber orthosis, one 20% more compliant and one 20% more stiff, were manufactured using selective laser sintering. Three-dimensional kinematic and kinetic data and electromyographic data were collected from each subject while they walked overground with each orthosis at their self-selected velocity and a controlled velocity. Findings: As the orthosis stiffness decreased, ankle range of motion and medial gastrocnemius activity increased while the knee became more extended throughout stance. Minimal changes in other kinematic, kinetic and electromyographic quantities were observed. Interpretation: Subjects effectively compensated for changes in ankle-foot orthosis stiffness with altered gastrocnemius activity, and the stiffness levels analyzed in this study had a minimal effect on overall walking performance. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Harper, Nicole G.; Neptune, Richard R.] Univ Texas Austin, Dept Mech Engn, Austin, TX 78712 USA. [Esposito, Elizabeth Russell; Wilken, Jason M.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ctr Intrepid, Ft Sam Houston, TX 78234 USA. RP Neptune, RR (reprint author), Univ Texas Austin, Dept Mech Engn, 204 E Dean Keeton St,Stop C2200, Austin, TX 78712 USA. EM rneptune@mail.utexas.edu OI Russell Esposito, Elizabeth/0000-0001-5321-0333; Wilken, Jason/0000-0002-5556-7667 FU National Science Foundation Graduate Research Fellowship; Center for Rehabilitation Sciences Research FX The authors would like to thank Deanna Gates, Jennifer Aldridge, Kelly Rodriguez, Derek Haight and Harmony Choi for their contributions to subject recruitment, and data collection and processing. This study was supported in part by a National Science Foundation Graduate Research Fellowship and a research grant from the Center for Rehabilitation Sciences Research. The contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Science Foundation. The view(s) expressed herein are those of the author(s) and do not reflect the official policy or position of Brooke Army Medical Center, the U.S. Army Medical Department, the U.S. Army Office of the Surgeon General, the Department of the Army, Department of Defense or the U.S. Government NR 49 TC 9 Z9 9 U1 3 U2 22 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0268-0033 EI 1879-1271 J9 CLIN BIOMECH JI Clin. Biomech. PD SEP PY 2014 VL 29 IS 8 BP 877 EP 884 DI 10.1016/j.clinbiomech.2014.07.005 PG 8 WC Engineering, Biomedical; Orthopedics; Sport Sciences SC Engineering; Orthopedics; Sport Sciences GA AW3WQ UT WOS:000346214400006 PM 25193884 ER PT J AU Sipos, ML Wood, MD Riviere, LA Adler, AB AF Sipos, Maurice L. Wood, Michael D. Riviere, Lyndon A. Adler, Amy B. TI Behavioral Health Adjustment in Reserve Component Soldiers During a Noncombat Deployment to Africa SO MILITARY PSYCHOLOGY LA English DT Article DE National Guard soldiers; behavioral health; unit climate; attitudes; combat history ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH; PSYCHOMETRIC PROPERTIES; MILITARY PERSONNEL; WAR VETERANS; IRAQ; COMBAT; AFGHANISTAN; CARE; US AB This study benchmarked rates of mental health problems, adjustment difficulties, and perceptions of unit climate among 505 U.S. soldiers (primarily National Guard) deployed to the Horn of Africa in 2012. In addition, the study examined whether differences across these outcomes exist between combat veterans (n = 239) and noncombat veterans (n = 242). Rates of mental health problems among soldiers on this noncombat deployment were lower than rates typically found among soldiers on combat deployments. Furthermore, soldiers without previous combat experience had lower rates of mental health problems and aggression than combat veterans. Similar differences were evident when adjustment difficulties and unit climate variables were compared. Although combat veterans could be valuable in training new soldiers, the results of this study indicate that combat veterans may need more targeted resources to facilitate their adjustment if they are to be optimally utilized. C1 [Sipos, Maurice L.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Wood, Michael D.; Adler, Amy B.] US Army Med Res Unit Europe, Walter Reed Army Inst Res, Sembach, Germany. [Riviere, Lyndon A.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Sipos, ML (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM maurice.l.sipos.mil@mail.mil NR 45 TC 1 Z9 1 U1 1 U2 3 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0899-5605 EI 1532-7876 J9 MIL PSYCHOL JI Milit. Psychol. PD SEP-NOV PY 2014 VL 26 IS 5-6 BP 409 EP 421 DI 10.1037/mil0000058 PG 13 WC Psychology, Multidisciplinary SC Psychology GA AW1AD UT WOS:000346021800006 ER PT J AU Meier, WN Hovelsrud, GK van Oort, BEH Key, JR Kovacs, KM Michel, C Haas, C Granskog, MA Gerland, S Perovich, DK Makshtas, A Reist, JD AF Meier, Walter N. Hovelsrud, Greta K. van Oort, Bob E. H. Key, Jeffrey R. Kovacs, Kit M. Michel, Christine Haas, Christian Granskog, Mats A. Gerland, Sebastian Perovich, Donald K. Makshtas, Alexander Reist, James D. TI Arctic sea ice in transformation: A review of recent observed changes and impacts on biology and human activity SO REVIEWS OF GEOPHYSICS LA English DT Review ID WESTERN HUDSON-BAY; SUBSURFACE CHLOROPHYLL MAXIMA; POLAR BEAR POPULATIONS; SOUTHERN BEAUFORT SEA; GLOBAL CLIMATE MODELS; MARINE MAMMALS; FRAM STRAIT; FOOD AVAILABILITY; BELUGA WHALES; TIPPING POINT AB Sea ice in the Arctic is one of the most rapidly changing components of the global climate system. Over the past few decades, summer areal extent has declined over 30%, and all months show statistically significant declining trends. New satellite missions and techniques have greatly expanded information on sea ice thickness, but many uncertainties remain in the satellite data and long-term records are sparse. However, thickness observations and other satellite-derived data indicate a 40% decline in thickness, due in large part to the loss of thicker, older ice cover. The changes in sea ice are happening faster than models have projected. With continued increasing temperatures, summer ice-free conditions are likely sometime in the coming decades, though there are substantial uncertainties in the exact timing and high interannual variability will remain as sea ice decreases. The changes in Arctic sea ice are already having an impact on flora and fauna in the Arctic. Some species will face increasing challenges in the future, while new habitat will open up for other species. The changes are also affecting people living and working in the Arctic. Native communities are facing challenges to their traditional ways of life, while new opportunities open for shipping, fishing, and natural resource extraction. Significant progress has been made in recent years in understanding of Arctic sea ice and its role in climate, the ecosystem, and human activities. However, significant challenges remain in furthering the knowledge of the processes, impacts, and future evolution of the system. C1 [Meier, Walter N.] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. [Hovelsrud, Greta K.; van Oort, Bob E. H.] Ctr Int Climate & Environm Res Oslo, Oslo, Norway. [Hovelsrud, Greta K.] Nordland Res Inst, Bodo, Norway. [Key, Jeffrey R.] NOAA, Madison, WI USA. [Kovacs, Kit M.; Granskog, Mats A.; Gerland, Sebastian] Norwegian Polar Res Inst, Tromso, Norway. [Michel, Christine; Reist, James D.] Fisheries & Oceans Canada, Winnipeg, MB, Canada. [Haas, Christian] Univ Alberta, Dept Earth & Atmospher Sci & Geophys, Edmonton, AB, Canada. [Perovich, Donald K.] US Army Cold Reg Res & Engn Lab, Hanover, NH USA. [Makshtas, Alexander] Arctic & Antarctic Res Inst, St Petersburg 199226, Russia. RP Meier, WN (reprint author), NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. EM walt.meier@nasa.gov RI Key, Jeffrey/F-5597-2010; Haas, Christian/L-5279-2016; OI Key, Jeffrey/0000-0001-6109-3050; Haas, Christian/0000-0002-7674-3500; Meier, Walter/0000-0003-2857-0550 FU Arctic Council; NASA; NOAA; U.S. Department of Defense; Norwegian Polar Institute; Fisheries and Oceans Canada FX This work was supported by the Arctic Council and the agencies employing and funding the authors including NASA, NOAA, U.S. Department of Defense, the Norwegian Polar Institute, and Fisheries and Oceans Canada. The views, opinions, and findings contained in this report are those of the author(s) and should not be construed as an official National Oceanic and Atmospheric Administration or U.S. Government position, policy, or decision. NR 270 TC 40 Z9 43 U1 26 U2 185 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 8755-1209 EI 1944-9208 J9 REV GEOPHYS JI Rev. Geophys. PD SEP PY 2014 VL 52 IS 3 BP 185 EP 217 DI 10.1002/2013RG000431 PG 33 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA AU5MI UT WOS:000345650700001 ER PT J AU Chennaoui, M Drogou, C Sauvet, F Gomez-Merino, D Scofield, DE Nindl, BC AF Chennaoui, Mounir Drogou, Catherine Sauvet, Fabien Gomez-Merino, Danielle Scofield, Denis E. Nindl, Bradley C. TI Effect of acute sleep deprivation and recovery on Insulin-like Growth Factor-I responses and inflammatory gene expression in healthy men SO EUROPEAN CYTOKINE NETWORK LA English DT Article DE IGF-1 system; proinflammatory cytokines; Toll-like receptor 4; sleep; healthy men ID TOLL-LIKE RECEPTORS; LARGE US SAMPLE; DAYTIME SLEEPINESS; HORMONE-SECRETION; RESTRICTION; CYTOKINES; RISK; DURATION; EXERCISE; OBESITY AB Acute sleep deprivation in humans has been found to increase inflammatory markers and signaling pathways in the periphery through a possible Toll-like receptor 4 (TLR-4). In addition, short duration sleep has been associated with low circulating total Insulin-like Growth Factor-I (IGF-I) concentrations. We aimed to determine whether a total sleep deprivation (TSD) protocol with recovery altered whole-blood gene expression of the proinflammatory cytokines TNF-alpha and IL-6, as well as TLR-4 expression, and to examine the relationship with circulating concentrations of the IGF-I system. Twelve healthy men participated in a five-day TSD (two control nights followed by one night of sleep deprivation and one night of recovery). Blood was sampled at 0800, before and after sleep deprivation (D2 and D4), and after recovery (D5). It is shown that 25h of sleep deprivation (D4) induced significant increases in mRNA levels of TNF-alpha and its soluble receptor R1 (P<0.01 respectively), as well as TLR-4 (P<0.05), while IL-6 mRNA levels remained unchanged. Circulating concentrations of free IGF-I were decreased at D4 (P<0.001). One night of recovery was sufficient to restore basal expression levels for TNF-alpha, sTNF-R1, TLR-4 and circulating IGF-I. Changes in TLR-4 mRNA levels during the protocol correlated positively with those of TNF-alpha and sTNF-R1 (r = 0.393 and r = 0.490 respectively), and negatively with circulating free IGF-I (r = -0.494). In conclusion, 25h of sleep deprivation in healthy subjects is sufficient to induce transient and reversible genomic expression of the pro-inflammatory cytokine TNF-alpha and its R1 receptor, and its mediator TLR-4, with a possible link to IGF-I axis inhibition. C1 [Chennaoui, Mounir; Drogou, Catherine; Sauvet, Fabien; Gomez-Merino, Danielle] French Armed Forces Biomed Res Inst IRBA, Neurosci & Operat Constraints Dept, Bretigny Sur Orge, France. [Chennaoui, Mounir; Drogou, Catherine; Sauvet, Fabien; Gomez-Merino, Danielle] Univ Paris 05, Sorbonne Paris Cite, Equipe Accueil Vigilance Fatigue & Sommeil, VIFASOM EA7330, Paris, France. [Scofield, Denis E.] US Army, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Nindl, Bradley C.] US Army, Inst Publ Hlth, Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. RP Chennaoui, M (reprint author), French Armed Forces Biomed Res Inst IRBA, Neurosci & Operat Constraints Dept, Bretigny Sur Orge, France. EM mounir.chennaoui@irba.fr RI SCOFIELD, DENNIS/F-3636-2015 FU French Delegation Generale pour l'Armement [08co704] FX This work was supported by the French Delegation Generale pour l'Armement (Contract No 08co704). We thank Mrs Delor, Bobee Elio and Mr Gourby, Mr Guillard, Mr Lapeyre, Mr Banzet and all personnel from IRBA and the Percy Military Hospital for their technical and logistic contributions to this work. We thank Jeff Staab from the US Army Research Institute of Environmental Medicine for his technical support and laboratory contribution. NR 35 TC 4 Z9 4 U1 0 U2 6 PU JOHN LIBBEY EUROTEXT LTD PI MONTROUGE PA 127 AVE DE LA REPUBLIQUE, 92120 MONTROUGE, FRANCE SN 1148-5493 J9 EUR CYTOKINE NETW JI Eur. Cytokine Netw. PD SEP PY 2014 VL 25 IS 3 BP 52 EP 57 DI 10.1684/ecn.2014.0356 PG 6 WC Biochemistry & Molecular Biology; Cell Biology; Immunology SC Biochemistry & Molecular Biology; Cell Biology; Immunology GA AT7PS UT WOS:000345130600003 PM 25373853 ER PT J AU McCallum, JR Cook, JB Hines, AC Shaha, JS Jex, JW Orchowski, JR AF McCallum, Jeremy R. Cook, Jay B. Hines, Adam C. Shaha, James S. Jex, Jefferson W. Orchowski, Joseph R. TI Return to Duty After Elective Fasciotomy for Chronic Exertional Compartment Syndrome SO FOOT & ANKLE INTERNATIONAL LA English DT Article DE chronic exertional compartment syndrome; functional outcome; sports medicine; lower extremity ID SURGICAL-TREATMENT; LOWER LEG; MANAGEMENT; OUTCOMES; DIAGNOSIS AB Background: Civilian literature has reported excellent outcomes after elective fasciotomy for chronic exertional compartment syndrome (CECS). Our study's purpose was to objectively investigate the functional outcome of fasciotomies performed for CECS in a high demand military population. Methods: A retrospective review of all fasciotomies performed for CECS at a single tertiary military medical center was performed. The primary outcome measure was the ability to return to full active duty. Diagnosis, operative technique, and number of compartments addressed were collected and analyzed. Patients were contacted and the visual analog scale (VAS) pain score, functional single assessment numeric evaluation (SANE) score, as well as overall satisfaction were reported. Return to duty status was collected on 70 of 70 (100%) consecutive operative extremities in 46 patients with an average follow-up of 26 months. Results: Only 19 patients (41.3%) were able to return to full active duty. Ten patients (21.7%) underwent a medical separation from the military and 17 patients (37%) remained in the military but were on restricted duty secondary to persistent leg pain. Thirty-five of 46 (76%) of the patients were contacted and provided subjective feedback. The average SANE score was 72.3, and there was a mean improvement of 4.4 points in VAS score postoperatively. Overall, 71% of patients were satisfied and would undergo the procedure again. Outcomes were correlated to operative technique, patient rank, and branch of military service. Conclusion: Our study showed a return to full military duty in 41% of patients who underwent elective fasciotomy for CECS. Overall 78% of patients remained in the military, which is consistent with previous military literature. Subjective satisfaction rate was 71%. Both the return to activity and subjective outcomes in our study population were substantially lower than reported results in civilian populations. C1 [McCallum, Jeremy R.; Cook, Jay B.; Hines, Adam C.; Shaha, James S.; Orchowski, Joseph R.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Jex, Jefferson W.] Walter Reed NMMC, Bethesda, MD USA. RP McCallum, JR (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM jeremy.r.mccallum@us.army.mil NR 18 TC 6 Z9 6 U1 0 U2 2 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1071-1007 EI 1944-7876 J9 FOOT ANKLE INT JI Foot Ankle Int. PD SEP PY 2014 VL 35 IS 9 BP 871 EP 875 DI 10.1177/1071100714539661 PG 5 WC Orthopedics SC Orthopedics GA AT8NI UT WOS:000345189400004 PM 25049368 ER PT J AU Ryan, P Hills, C Chang, J Wilson, D AF Ryan, Paul Hills, Chad Chang, James Wilson, David TI The Lambda Sign: A New Radiographic Indicator of Latent Syndesmosis Instability SO FOOT & ANKLE INTERNATIONAL LA English DT Article DE syndesmosis; instability; lambda sign; tibiofibular clear space; tibiofibular overlap; external rotation stress test; proximal squeeze test ID TIBIOFIBULAR SYNDESMOSIS; ANKLE; DIAGNOSIS; ARTHROSCOPY; FRACTURE; SPRAINS; INJURY AB Background: Latent syndesmotic instability is a common cause of chronic ankle pain. The diagnosis is not readily apparent on static imaging as the fibula remains reduced. The hypothesis of this study was that a previously undescribed novel finding on coronal MRI (lambda sign) is an independent indicator of latent syndesmosis instability. We also report on the utility of classic radiographic and physical exam findings. Methods: A total of 23 patients with latent syndesmotic instability diagnosed via arthroscopy (group I) were compared to a cohort of 40 patients who were found to have a stable syndesmosis during arthroscopy for unrelated conditions (group II). A retrospective chart review was performed evaluating their clinical history, preoperative physical examination, and radiologic findings. The lambda sign is a high intensity signal seen on coronal MR imaging that resembles the Greek letter lambda. Results: All of the physical exam findings tested were statistically significant. Pain at the syndesmosis had the highest sensitivity (83%), while pain reproduced with the proximal squeeze test resulted in the highest specificity (89%). The external rotation stress test had the highest positive predictive value (75%). Of the radiographic examinations performed, only the lambda sign was found to have statistical significance with a sensitivity of 75% and a specificity of 63%. The presence of a lambda sign on the MRI of patients with physical exam findings suggestive of syndesmotic pain was highly sensitive (75%) and specific (85%). Conclusion: The lambda sign noted on the coronal MRI was both sensitive and specific for injuries involving greater than 2 mm of diastasis on arthroscopic stress examination of the syndesmosis. While neither the lambda sign nor any other finding on physical or radiographic examination represented an independent predictor of syndesmotic instability, the presence of a lambda sign in concert with positive physical exam findings might help health care providers determine which patients might benefit from operative intervention or referral. C1 [Ryan, Paul] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Hills, Chad] US Army, CSH BAACH 121, Washington, DC USA. [Chang, James; Wilson, David] Madigan Army Med Ctr, Tacoma, WA 98431 USA. RP Ryan, P (reprint author), Tripler Army Med Ctr, Orthopaed Serv, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM paulryan1@hotmail.com NR 19 TC 0 Z9 0 U1 0 U2 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1071-1007 EI 1944-7876 J9 FOOT ANKLE INT JI Foot Ankle Int. PD SEP PY 2014 VL 35 IS 9 BP 903 EP 908 DI 10.1177/1071100714543646 PG 6 WC Orthopedics SC Orthopedics GA AT8NI UT WOS:000345189400008 ER PT J AU Collier, ZA Linkov, I DiMase, D Walters, S Tehranipoor, M Lambert, JH AF Collier, Zachary A. Linkov, Igor DiMase, Daniel Walters, Steve Tehranipoor, Mark (Mohammad) Lambert, James H. TI Cybersecurity Standards: Managing Risk and Creating Resilience SO COMPUTER LA English DT Article AB A risk-based cybersecurity framework must continuously assimilate new information and track changing stakeholder priorities and adversarial capabilities, using decision-analysis tools to link technical data with expert judgment. C1 [Collier, Zachary A.; Linkov, Igor] US Army Engineer, Ctr Res & Dev, Washington, DC 20314 USA. [DiMase, Daniel; Walters, Steve] Soc Automot Engineers G19 Test Lab Stand Dev Comm, Risk Characterizat Subgrp, Edinburgh, Midlothian, Scotland. [Tehranipoor, Mark (Mohammad)] Univ Connecticut, Storrs, CT USA. [Tehranipoor, Mark (Mohammad)] Univ Connecticut, Ctr Hardware Assurance Secur & Engn, Storrs, CT USA. [Lambert, James H.] Univ Virginia, Dept Syst & Informat Engn, Charlottesville, VA 22903 USA. RP Collier, ZA (reprint author), US Army Engineer, Ctr Res & Dev, Washington, DC 20314 USA. EM zachary.a.collier@usace.army.mil; igor.linkov@usace.army.mil; daniel.dimase@honeywell.com; steve.w.walters@honeywell.com; tehrani@engr.uconn.edu; lambert@virginia.edu NR 14 TC 2 Z9 3 U1 1 U2 6 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 0018-9162 EI 1558-0814 J9 COMPUTER JI Computer PD SEP PY 2014 VL 47 IS 9 BP 70 EP 76 PG 7 WC Computer Science, Hardware & Architecture; Computer Science, Software Engineering SC Computer Science GA AS8CO UT WOS:000344478100028 ER PT J AU Mukhopadhyay, S Pandey, R Karna, SP AF Mukhopadhyay, S. Pandey, R. Karna, S. P. TI Microscopic insight into molecular orbital gating SO INDIAN JOURNAL OF PHYSICS LA English DT Article DE Molecular transistor; Orbital gating; Mesoscopic transport; BDT; ODT ID TRANSISTOR; DENSITY AB The molecular orbital gating in the 1,8-octanedithiol (ODT) and 1,4-benzenedithiol (BDT) molecules is investigated using first principles methods. The calculated I-V characteristics as a function of applied gate voltage for the sigma-saturated ODT molecule are found to depend on the microscopic description of the conduction channels. On the other hand, an orbital gating in the BDT-based molecular device system, within the practical limit, is not seen. We find that a non-zero dipole moment along the gate-direction is indispensable in order to obtain the gate-field induced transistor effect, which BDT does not qualify for, due to its symmetric planar structure. C1 [Mukhopadhyay, S.; Pandey, R.] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. [Karna, S. P.] US Army Res Lab, Weap & Mat Res Directorate, ATTN AMSRD ARL WM, Aberdeen, MD 21005 USA. RP Mukhopadhyay, S (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. EM smukhopa@mtu.edu; Shashi.p.karna.civ@mail.mil RI Mukhopadhyay, Saikat/B-4402-2011 FU Army Research Office [W911NF-09-1-0221] FX Helpful discussions with Haiying He and Ranjit Pati are duly acknowledged. The work at Michigan Technological University was performed under support by the Army Research Office through Contract Number W911NF-09-1-0221. NR 21 TC 0 Z9 0 U1 1 U2 5 PU INDIAN ASSOC CULTIVATION SCIENCE PI KOLKATA PA INDIAN J PHYSICS, JADAVPUR, KOLKATA 700 032, INDIA SN 0973-1458 EI 0974-9845 J9 INDIAN J PHYS JI Indian J. Phys. PD SEP PY 2014 VL 88 IS 9 SI SI BP 945 EP 950 DI 10.1007/s12648-014-0482-x PG 6 WC Physics, Multidisciplinary SC Physics GA AT2QE UT WOS:000344778400009 ER PT J AU Hromadka, TV McInvale, HD Gatzke, B Phillips, M Espinosa, B AF Hromadka, T. V., II McInvale, H. D. Gatzke, B. Phillips, M. Espinosa, B. TI Cumulative Departure Model of the Cryosphere During the Pleistocene SO JOURNAL OF COLD REGIONS ENGINEERING LA English DT Article DE Global climate change; Cryosphere; Mathematical model; Phase change; Differential equation model; Cumulative departure method ID VOSTOK ICE-CORE; FREEZING FRONTS; SOIL; CLIMATE; HEAT; SEGREGATION; RECORD AB A mathematical model is developed to describe changes in ice volume in the cryosphere. Modeling the cryosphere may be useful in assessing future climate impacts currently captured by global circulation models (GCMs) by providing an opportunity to validate GCMs. Leveraging the dominating effects of freezing and thawing in the cryosphere to simplify relevant heat transport equations allows for the derivation of a mathematical model that can be solved exactly. Such exact solutions are useful in investigating other climatic components that may be similarly analyzed for possible GCM validation. The current trend in GCM advancement is to increase the complexity and sophistication of the various heat transport effects that are represented in the governing mathematical model in cumulative form as the heat forcing function. In this paper, simplified models are developed whose solution can be directly compared with available data forms representing temperature and ice volume during the Pleistocene. With careful integration of the Pleistocene temperature term in the mathematical solution, the well-known cumulative departure method can be resolved from the mathematical solution using a two-term expansion of the corresponding Taylor series. This simplification is shown to be a good approximation of the Pleistocene ice volume for given Pleistocene temperatures. C1 [Hromadka, T. V., II; McInvale, H. D.; Gatzke, B.; Phillips, M.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Espinosa, B.] Hromadka & Associates, Rancho Santa Margarita, CA 92688 USA. RP Hromadka, TV (reprint author), US Mil Acad, Dept Math Sci, 626 Swift Rd, West Point, NY 10996 USA. EM tedhromadka@yahoo.com; Doug.McInvale@usma.edu; Benjamin.Gatzke@usma.edu; Michael.Phillips@usma.edu; bespinosa@sbcglobal.net FU United States Military Academy, West Point, New York, Department of Mathematical Sciences FX Acknowledgements are paid to the United States Military Academy, West Point, New York, Department of Mathematical Sciences, for their support to the authors during this research. Also acknowledged are the several individuals who have participated in particular tasks in developing this paper, including but by no means limited to Rene Perez, Laura Hromadka, Michael Barton, and T. V. Hromadka III. NR 37 TC 0 Z9 0 U1 1 U2 6 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0887-381X EI 1943-5495 J9 J COLD REG ENG JI J. Cold Reg. Eng. PD SEP PY 2014 VL 28 IS 3 AR 06014002 DI 10.1061/(ASCE)CR.1943-5495.0000071 PG 14 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA AT2PK UT WOS:000344776500003 ER PT J AU Bedair, SS Pulskamp, JS Meyer, CD Polcawich, RG Kierzewski, IM AF Bedair, S. S. Pulskamp, J. S. Meyer, C. D. Polcawich, R. G. Kierzewski, I. M. TI Modeling, fabrication and testing of MEMS tunable inductors varied with piezoelectric actuators SO JOURNAL OF MICROMECHANICS AND MICROENGINEERING LA English DT Article DE tunable inductors; variable inductors; RF-MEMS inductors; inductance modeling ID VARIABLE INDUCTOR; SPIRAL INDUCTORS; RF; SILICON; PERFORMANCE; DENSITY; SYSTEMS; DESIGN AB Modeling, fabrication and measurements of tunable inductors are presented where inductance tuning is achieved through mechanical displacement, by piezoelectric actuation, of mutually-coupled coils. The modified Greenhouse method is utilized as a modeling tool to predict the inductance variations as a function of both translation and angular displacement, where coils and traces which are arbitrarily oriented with respect to one another are considered. The use of this modeling approach is verified through experimental results where electrical measurements of inductances are compared with the modeled inductances. The inductance model compares well with the measurements and within 10% of the measured inductance with a 3% mean error. In addition, the impact of the interconnect widths on tunable inductor performances is assessed for both negatively and positively coupled tunable inductor cases, where devices with interconnect widths ranging between 10 and 40 mu m are considered. Tuning ratios as high as similar to 3.9:1 were measured for the negatively-coupled coil designs with 18 V actuation; this corresponds to minimum and maximum quality factors of 5.72 (at 4.05 GHz with a 2.80 nH inductance) and 14.91 (at 2.25 GHz with 10.86 nH inductance), respectively. For the positively coupled inductors, tuning ratios of similar to 1.2:1 resulted with inductance and peak quality factors of 7.70 nH and similar to 18 (3.69 GHz), respectively. With 18 V actuation, these values tune to 6.57 nH with a Q similar to 18 (4.46 GHz). Residual poling stress was found to limit the practical tuning ratio to similar to 1.8:1 for the negatively coupled coils. C1 [Bedair, S. S.; Pulskamp, J. S.; Meyer, C. D.; Polcawich, R. G.; Kierzewski, I. M.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Bedair, SS (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM sarah.s.bedair.civ@mail.mil NR 37 TC 2 Z9 2 U1 2 U2 15 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0960-1317 EI 1361-6439 J9 J MICROMECH MICROENG JI J. Micromech. Microeng. PD SEP PY 2014 VL 24 IS 9 AR 095017 DI 10.1088/0960-1317/24/9/095017 PG 12 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Instruments & Instrumentation; Physics, Applied SC Engineering; Science & Technology - Other Topics; Instruments & Instrumentation; Physics GA AS8TT UT WOS:000344521600018 ER PT J AU Bedno, SA Urban, N Boivin, MR Cowan, DN AF Bedno, S. A. Urban, N. Boivin, M. R. Cowan, D. N. TI Fitness, obesity and risk of heat illness among army trainees SO OCCUPATIONAL MEDICINE-OXFORD LA English DT Article DE Body fat; fitness test; heat illness; military; obesity ID PHYSICAL-FITNESS; PREACCESSION FITNESS; RECRUIT MOTIVATION; INJURIES; U.S.; ATTRITION; STRENGTH AB Background Exertional heat illness (EHI) affects military personnel, athletes and occupational groups such as agricultural workers, despite knowledge of preventive measures. Aims To evaluate EHI diagnoses during US Army basic training and its associations with fitness and body fat on entering military service. Methods From February 2005 to September 2006, US Army recruits at six different military entrance stations took a pre-accession fitness test, including a 5-min step test scored as pass or fail. Subsequent EHI incidence and incidence rate ratios were analysed with reference to subjects' fitness (step test performance) and whether they met (weight qualified [WQ]) or exceeded body fat (EBF) standards. Results Among the 8621 WQ and 834 EBF male subjects, there were 67 incidents of EHI within 180 days of entering military service. Among WQ subjects, step test failure was significantly associated with EHI (odds ratio [OR] 2.00, 95% confidence interval [CI] 1.13, 3.53). For those passing the step test, the risk of EHI was significantly higher in EBF than in WQ subjects (OR 3.98, 95% CI 2.17, 7.29). Expected ORs for the joint effects of step test failure and EBF classification under additive and multiplicative models were 4.98 and 7.96, respectively. There were too few women to evaluate their data in detail. Conclusions This study demonstrated that fitness and body fat are independently associated with incident EHI, and the effect of both was substantially higher. Those with low fitness levels and/or obesity should be evaluated further before engaging in intense physical activity, especially in warmer months. C1 [Bedno, S. A.] William Beaumont Army Med Ctr, Dept Clin Invest, El Paso, TX 79920 USA. [Urban, N.; Boivin, M. R.; Cowan, D. N.] Walter Reed Army Inst Res, Prevent Med Program, Silver Spring, MD 20901 USA. [Urban, N.; Cowan, D. N.] ManTech Int Corp, Mission Solut & Serv, Herndon, VA 22033 USA. RP Bedno, SA (reprint author), William Beaumont Army Med Ctr, 5005 Piedras St, El Paso, TX 79920 USA. EM sheryl.a.bedno.mil@mail.mil FU United States Army Accession Command FX United States Army Accession Command. NR 20 TC 5 Z9 6 U1 2 U2 6 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0962-7480 EI 1471-8405 J9 OCCUP MED-OXFORD JI Occup. Med.-Oxf. PD SEP PY 2014 VL 64 IS 6 BP 461 EP 467 DI 10.1093/occmed/kqu062 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AT1SS UT WOS:000344714900016 PM 25022280 ER PT J AU Lim, RB AF Lim, Robert B. TI Comment on: Experience of excess skin after gastric bypass or duodenal switch in patients with super obesity SO SURGERY FOR OBESITY AND RELATED DISEASES LA English DT Editorial Material C1 Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. RP Lim, RB (reprint author), Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1550-7289 EI 1878-7533 J9 SURG OBES RELAT DIS JI Surg. Obes. Relat. Dis. PD SEP-OCT PY 2014 VL 10 IS 5 BP 897 EP 897 PG 1 WC Surgery SC Surgery GA AT1UL UT WOS:000344719200029 PM 25439002 ER PT J AU Gutmann, E Pruitt, T Clark, MP Brekke, L Arnold, JR Raff, DA Rasmussen, RM AF Gutmann, Ethan Pruitt, Tom Clark, Martyn P. Brekke, Levi Arnold, Jeffrey R. Raff, David A. Rasmussen, Roy M. TI An intercomparison of statistical downscaling methods used for water resource assessments in the United States SO WATER RESOURCES RESEARCH LA English DT Article DE statistical downscaling; Bias Corrected Spatial Disaggregation (BCSD); Bias Corrected Constructed Analog (BCCA); Asynchronous Regression ID HYDROLOGICALLY BASED DATASET; CLIMATE-CHANGE IMPACTS; LAND-SURFACE FLUXES; DAILY PRECIPITATION; DAILY TEMPERATURE; MODEL OUTPUT; BIAS CORRECTION; RESOLUTION; CALIFORNIA; STREAMFLOW AB Information relevant for most hydrologic applications cannot be obtained directly from the native-scale outputs of climate models. As a result the climate model output must be downscaled, often using statistical methods. The plethora of statistical downscaling methods requires end-users to make a selection. This work is intended to provide end-users with aid in making an informed selection. We assess four commonly used statistical downscaling methods: daily and monthly disaggregated-to-daily Bias Corrected Spatial Disaggregation (BCSDd, BCSDm), Asynchronous Regression (AR), and Bias Corrected Constructed Analog (BCCA) as applied to a continental-scale domain and a regional domain (BCCAr). These methods are applied to the NCEP/NCAR Reanalysis, as a surrogate for a climate model, to downscale precipitation to a 12 km gridded observation data set. Skill is evaluated by comparing precipitation at daily, monthly, and annual temporal resolutions at individual grid cells and at aggregated scales. BCSDd and the BCCA methods overestimate wet day fraction, and underestimate extreme events. The AR method reproduces extreme events and wet day fraction well at the grid-cell scale, but over (under) estimates extreme events (wet day fraction) at aggregated scales. BCSDm reproduces extreme events and wet day fractions well at all space and time scales, but is limited to rescaling current weather patterns. In addition, we analyze the choice of calibration data set by looking at both a 12 km and a 6 km observational data set; the 6 km observed data set has more wet days and smaller extreme events than the 12 km product, the opposite of expected scaling. C1 [Gutmann, Ethan; Clark, Martyn P.; Rasmussen, Roy M.] Natl Ctr Atmospher Res, Boulder, CO 80307 USA. [Pruitt, Tom; Brekke, Levi] US Bur Reclamat, Denver, CO 80225 USA. [Arnold, Jeffrey R.] US Army Corps Engineers, Seattle, WA USA. [Raff, David A.] US Army Corps Engineers, Alexandria, VA USA. RP Gutmann, E (reprint author), Natl Ctr Atmospher Res, POB 3000, Boulder, CO 80307 USA. EM gutmann@ucar.edu RI Clark, Martyn/A-5560-2015; Gutmann, Ethan/I-5728-2012 OI Clark, Martyn/0000-0002-2186-2625; Gutmann, Ethan/0000-0003-4077-3430 FU United States Bureau of Reclamation (USBR); United States Army Corps of Engineers (USACE); National Center for Atmospheric Research (NCAR); National Science Foundation [NSF AGS-0753581] FX NCEP Reanalysis data provided by the NOAA/OAR/ESRL PSD, Boulder, Colorado, USA, from their Web site at http://www.esrl.noaa.gov/psd/. The Maurer et al. [2002] gridded observations of precipitation are available online at http://hydro.engr.scu.edu/files/gridded_obs/daily/ncfiles/. The Livneh et al. [2013] gridded observations of precipitation are available online at ftp://ftp.hydro.washington.edu/pub/blivneh/CONUS/. This research has been funded by a cooperative agreement with the United States Bureau of Reclamation (USBR), a contract with the United States Army Corps of Engineers (USACE), and the National Center for Atmospheric Research (NCAR). NCAR is sponsored by the National Science Foundation (NSF AGS-0753581). Bridget Thrasher provided code for the BCSD and BCCA downscaling methods. We are grateful to Patrick Laux and three anonymous reviewers for their contributions in making this a stronger manuscript. NR 72 TC 26 Z9 26 U1 1 U2 40 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0043-1397 EI 1944-7973 J9 WATER RESOUR RES JI Water Resour. Res. PD SEP PY 2014 VL 50 IS 9 BP 7167 EP 7186 DI 10.1002/2014WR015559 PG 20 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA AR9YK UT WOS:000343933400007 ER PT J AU Hoole, SRH Sivasuthan, S Karthik, VU Rahunanthan, A Thyagarajan, RS Jayakumar, P AF Hoole, S. Ratnajeevan H. Sivasuthan, Sivamayam Karthik, Victor U. Rahunanthan, Arunasalam Thyagarajan, Ravi S. Jayakumar, Paramsothy TI Electromagnetic Device Optimization: The Forking of Already Parallelized Threads on Graphics Processing Units SO APPLIED COMPUTATIONAL ELECTROMAGNETICS SOCIETY JOURNAL LA English DT Article DE Finite elements; GPU computing; inverse problems; parallelization AB In light of the new capability to fork an already parallelized kernel on a GPU, this paper shows how the use of the parallelization capabilities of a PC's Graphics Processing Unit (GPU) makes the finite element design of coupled problems (such as the electroheat shape optimization problems we work with) realistic and practicable in terms of computational time. C1 [Hoole, S. Ratnajeevan H.; Sivasuthan, Sivamayam; Karthik, Victor U.] Michigan State Univ, Dept Elect & Comp Engn, E Lansing, MI 48824 USA. [Rahunanthan, Arunasalam] Edinboro Univ, Dept Math & Comp Sci, Edinboro, PA 16444 USA. [Thyagarajan, Ravi S.; Jayakumar, Paramsothy] US Army Tank Automot Res, Ctr Dev & Engn, Warren, MI 48397 USA. RP Hoole, SRH (reprint author), Michigan State Univ, Dept Elect & Comp Engn, E Lansing, MI 48824 USA. EM srhhoole@gmail.com; sivasuth@msu.edu; uthayaku@msu.edu; rahunanthana@gmail.com; ravi.s.thyagarajan.civ@mail.mil; paramsothy.jayakumar.civ@mail.mil FU US Army's Tank, Automotive Research, Development and Engineering Center (TARDEC) [W911NF-11-D-0001] FX This work was funded in part by the US Army's Tank, Automotive Research, Development and Engineering Center (TARDEC), under contract number W911NF-11-D-0001. This paper has been approved by the US Army's Tank, Automotive Research, Development and Engineering Center (TARDEC) with the statement: "UNCLASSIFIED: Distribution Statement A. Approved for public release." NR 13 TC 4 Z9 4 U1 1 U2 3 PU APPLIED COMPUTATIONAL ELECTROMAGNETICS SOC PI UNIVERSITY PA UNIV MISSISSIPPI, DEPT ELECTRICAL ENGINEERING, UNIVERSITY, MS 38677 USA SN 1054-4887 EI 1943-5711 J9 APPL COMPUT ELECTROM JI Appl. Comput. Electromagn. Soc. J. PD SEP PY 2014 VL 29 IS 9 BP 677 EP 684 PG 8 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA AR8XT UT WOS:000343855400001 ER PT J AU Quinn, MJ Bannon, DI Jackovitz, AM Hanna, TL Shiflett, AA Johnson, MS AF Quinn, M. J., Jr. Bannon, D. I. Jackovitz, A. M. Hanna, T. L. Shiflett, A. A. Johnson, M. S. TI Assessment of 3-Nitro-1,2,4-triazol-5-one as a Potential Endocrine Disrupting Chemical in Rats Using the Hershberger and Uterotrophic Bioassays SO INTERNATIONAL JOURNAL OF TOXICOLOGY LA English DT Article DE 932-64-9; endocrine disruption; uterotrophic; Hershberger; 3-nitro-1; 2; 4-triazol-5-one AB The explosive 3-nitro-1,2,4-triazol-5-one (NTO) is an insensitive formulation developed to replace high energetics that are susceptible to accidental detonation from heat, shock, and impact. Although studies have shown NTO to be nontoxic at acute exposures, recent subacute and subchronic tests have demonstrated effects on testes and subsequent sperm production in rats. This study assessed endocrine disruption as a potential mechanism for these reproductive effects via the Hershberger and uterotrophic bioassays. These assays are 2 of the US Environmental Protection Agency's tier 1 in vivo screens for the Endocrine Disruptor Screening Program that measure differences in androgen- and estrogen-sensitive tissue weights in castrated and ovariectomized rats. The gonadectomized rats were orally exposed to NTO in a corn oil vehicle at doses of 250, 500, or 1000 mg/kg body weight (bw)/d for 10 and 3 days for the Hershberger and uterotrophic assays, respectively, according to standard protocols. Male rats also received testosterone (0.2 mg/kg/d, subcutaneous) and antiandrogenic flutamide (3mg/kg/d, oral) as negative and positive controls, and females received 17 -ethynyl estradiol (0.3 mu g/d, subcutaneous) as positive controls. 3-Nitro-1,2,4-triazol-5-one caused neither a decrease in androgen-sensitive male reproductive selected tissue (seminal vesicles with fluid/without fluid, glans penis, Cowper gland, ventral prostrate, and levator ani-bulbocavernosus) weights nor a change in uterine weights. The results of this study provide no evidence to suggest that NTO acts like an estrogenic or antiandrogenic endocrine disruptor in rats at these doses. C1 [Quinn, M. J., Jr.] US Army Ctr Hlth Promot & Prevent Med, Aberdeen, MD USA. [Bannon, D. I.; Jackovitz, A. M.; Hanna, T. L.; Shiflett, A. A.; Johnson, M. S.] US Army Publ Hlth Command, Aberdeen, MD USA. RP Quinn, MJ (reprint author), US Army Ctr Hlth Promot & Prevent Med, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM michael.james.quinn@us.army.mil FU US Army Research Development and Engineering Command (RDECOM) Environmental Acquisition and Logistics Sustainment Program (EASLP), Aberdeen Proving Ground, MD [21010] FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was funded by the US Army Research Development and Engineering Command (RDECOM) Environmental Acquisition and Logistics Sustainment Program (EASLP), Aberdeen Proving Ground, MD 21010. NR 9 TC 4 Z9 4 U1 3 U2 9 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1091-5818 EI 1092-874X J9 INT J TOXICOL JI Int. J. Toxicol. PD SEP-OCT PY 2014 VL 33 IS 5 BP 367 EP 372 DI 10.1177/1091581814548729 PG 6 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA AR7ZX UT WOS:000343796500004 PM 25185974 ER PT J AU Angerhofer, RA Michie, MW Leach, GJ Johnson, MS Reddy, G AF Angerhofer, Richard A. Michie, Mark W. Leach, Glenn J. Johnson, Mark S. Reddy, Gunda TI Oral Toxicity Evaluation of Thiodiglycol in Sprague-Dawley Rats SO INTERNATIONAL JOURNAL OF TOXICOLOGY LA English DT Article DE thiodiglycol; CAS 111-48-8; oral toxicity; rats; sulfur mustard; NOAEL; BMDL ID BETA-LYASE METABOLITES; SULFUR MUSTARD; BIOLOGICAL FATE; HYDROLYSIS PRODUCTS; ALLEGED ATTACK; IDENTIFICATION; URINE; GAS; 1,1'-THIOBIS(2-CHLOROETHANE); DEGRADATION AB Thiodiglycol (TDG) is the main product of sulfur mustard hydrolysis and is an environmental contaminant. Subacute and subchronic oral toxicity studies with TDG were conducted in Sprague-Dawley rats. Neat TDG was administered by gavage at doses of 157, 313, 625, 1250, 2500, 5000, and 9999 mg/kg/d, 5 days per week, for 14 days. In the 14-day study, decreased body weight and food consumption were observed at 5000 mg/kg/d. In the 90-day study, rats received neat TDG at doses of 50, 500, or 5000 mg/kg/d for 5 days per week. A fourth group served as a sham control. Individual body weight and food consumption were measured weekly. At termination of the experiment, urine, blood, and tissue samples were collected. Rats displayed significant decreased body weight with no effect on food consumption following administration of TDG at 5000 mg/kg/d. Both male and female rats showed significant increased kidney weights at 5000 mg/kg/d. The organ to body weight ratios increased significantly for liver, kidneys, testes, and brain in males and adrenals in females for 5000 mg/kg/d. At all doses of TDG, hematological and clinical parameters and tissue histopathology remained unaltered. The no observed adverse effect level (NOAEL) for oral subchronic toxicity was 500 mg/kg/d. Benchmark dose (BMD) was derived from the decreased gain in body weight that was seen in male rats. A BMD based on a 10% decrease in body weight was 1704 mg/kg/d, and the lower confidence limit on the dose BMD, the BMDL, was 372 mg/kg/d. C1 [Angerhofer, Richard A.; Michie, Mark W.; Leach, Glenn J.; Johnson, Mark S.; Reddy, Gunda] US Army Publ Hlth Command, Army Inst Publ Hlth, Aberdeen, MD USA. RP Reddy, G (reprint author), US Army Publ Hlth Command, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM gunda.reddy.civ@mail.mil FU US Army Corps of Engineers' Environmental Technology Program FX The author(s) disclosed receipt of the following financial support for the research, authorship, and /or publication of this article: US Army Corps of Engineers' Environmental Technology Program. NR 37 TC 1 Z9 1 U1 1 U2 2 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1091-5818 EI 1092-874X J9 INT J TOXICOL JI Int. J. Toxicol. PD SEP-OCT PY 2014 VL 33 IS 5 BP 393 EP 402 DI 10.1177/1091581814547541 PG 10 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA AR7ZX UT WOS:000343796500007 PM 25163473 ER PT J AU Klenow, DJ Reibestein, JL AF Klenow, Daniel J. Reibestein, Jeffrey L. TI Eyes to the Sky: Situating the Role of Storm Spotters in the Warning and Response Network SO JOURNAL OF HOMELAND SECURITY AND EMERGENCY MANAGEMENT LA English DT Article DE emergency management; motivation; severe weather; SKYWARN (R); storm spotters; tornadoes; warning ID DECISION-MAKING; OPERATIONAL METEOROLOGY; GROUND-TRUTH; COMMUNICATION AB This article presents data from a study of SKYWARN (R) storm spotters. The findings focus on their motivations for participation in storm spotting, their conceptualizations of storm spotting activity, their perceptions of risk, and how they balance personal and professional obligations with storm spotting activities. C1 [Klenow, Daniel J.] N Dakota State Univ, Dept Emergency Management, Fargo, ND 58108 USA. [Reibestein, Jeffrey L.] US Army, Joint Logist Operat Ctr, APO, AE 09751 USA. RP Klenow, DJ (reprint author), N Dakota State Univ, Dept Emergency Management, Minard Hall,POB 6050, Fargo, ND 58108 USA. EM daniel.klenow@ndsu.edu NR 24 TC 2 Z9 2 U1 1 U2 5 PU WALTER DE GRUYTER GMBH PI BERLIN PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY SN 2194-6361 EI 1547-7355 J9 J HOMEL SECUR EMERG JI J. Homel. Secur. Emerg. Manag. PD SEP PY 2014 VL 11 IS 3 BP 437 EP 458 DI 10.1515/jhsem-2014-0011 PG 22 WC Public Administration SC Public Administration GA AR9AZ UT WOS:000343864400008 ER PT J AU Bhagwandin, VA Sahu, J AF Bhagwandin, Vishal A. Sahu, Jubaraj TI Numerical Prediction of Pitch Damping Stability Derivatives for Finned Projectiles SO JOURNAL OF SPACECRAFT AND ROCKETS LA English DT Article ID NAVIER-STOKES PREDICTIONS; CONING MOTION; GENERALIZED FORMULATION; AERODYNAMICS; BODIES AB Reynolds-averaged Navier-Stokes computational fluid dynamics and linear flight mechanics theory were used to compute the pitch damping dynamic stability derivatives for two basic finned projectiles using two numerical methods, namely, the transient planar pitching method and the steady lunar coning method. Numerical results were compared with free-flight and wind-tunnel experimental data for Mach numbers in the range of 0.5-4.5. The accuracy, efficiency, and dependence of these methods on various aerodynamic and numerical modeling parameters were investigated. The numerical methods generally showed good agreement with each other, except at some transonic Mach numbers. Both methods showed good to excellent agreement with experimental data in the high transonic and supersonic Mach regimes. In the subsonic and low transonic regimes, agreement between numerical and experimental data was less favorable. The accuracy of the free-flight test data in these regimes was uncertain due to instances of large scatter, large standard deviation errors, and different data sources showing significantly different results. C1 [Bhagwandin, Vishal A.; Sahu, Jubaraj] US Army, Res Lab, Flight Sci Branch, Weap & Mat Res Directorate,RDRL WML E, Aberdeen Proving Ground, MD 21005 USA. RP Bhagwandin, VA (reprint author), US Army, Res Lab, Flight Sci Branch, Weap & Mat Res Directorate,RDRL WML E, Aberdeen Proving Ground, MD 21005 USA. FU U.S. Department of Defense (DoD) FX This work was supported in part by a grant of high-performance computing time from the U.S. Department of Defense (DoD) High-Performance Computing Modernization Program at the Army Research Laboratory DoD Supercomputing Resource Center at Aberdeen Proving Ground, Maryland. The authors would like to thank James DeSpirito and PaulWeinacht of the U.S. Army Research Laboratory at Aberdeen Proving Ground, Maryland, for their technical guidance on the subject matter. NR 32 TC 3 Z9 4 U1 0 U2 4 PU AMER INST AERONAUTICS ASTRONAUTICS PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0022-4650 EI 1533-6794 J9 J SPACECRAFT ROCKETS JI J. Spacecr. Rockets PD SEP-OCT PY 2014 VL 51 IS 5 BP 1603 EP 1618 DI 10.2514/1.A32734 PG 16 WC Engineering, Aerospace SC Engineering GA AR8AH UT WOS:000343797500018 ER PT J AU Imerbsin, R Chumpolkulwong, K Hanrujirakomjohn, A Saithasao, M Sirivisoot, S Tayamun, S Inamnuay, L Lombardini, ED AF Imerbsin, Rawiwan Chumpolkulwong, Kesara Hanrujirakomjohn, Alongkorn Saithasao, Mana Sirivisoot, Sirintra Tayamun, Sujitra Inamnuay, Laksanee Lombardini, Eric D. TI Seminal Vesicle Carcinoma-In-Situ in An Adult Rhesus Macaque: A Case Report and Review of The Literature SO THAI JOURNAL OF VETERINARY MEDICINE LA English DT Article DE adenocarcinoma; histopathology; malignant; rhesus macaque; seminal vesicle ID SPONTANEOUS NEOPLASMS; ADENOCARCINOMA; TUMOR AB A seminal vesicle carcinoma-in-situ was diagnosed as an incidental finding during histopathological evaluation of necropsy tissues in a 9 year old intact male Indian origin Rhesus macaque. The animal had been used in a series of infectious disease studies and in a terminal renal transplantation experiment over the course of its life at the Armed Forces Research Institute of Medical Sciences. Diagnosis was proffered by a board certified (ACVP) veterinary pathologist due to the microscopic appearance of the neoplasm and confirmed using immunohistochemistry. This report represents the first description of a seminal vesicle carcinoma-in-situ in a non-human primate. C1 [Imerbsin, Rawiwan; Chumpolkulwong, Kesara; Hanrujirakomjohn, Alongkorn; Saithasao, Mana; Tayamun, Sujitra; Inamnuay, Laksanee; Lombardini, Eric D.] Armed Forces Res Inst Med Sci, Div Comparat Pathol, Bangkok 10400, Thailand. [Imerbsin, Rawiwan; Chumpolkulwong, Kesara; Hanrujirakomjohn, Alongkorn; Saithasao, Mana; Tayamun, Sujitra; Inamnuay, Laksanee; Lombardini, Eric D.] Armed Forces Res Inst Med Sci, Div Vet Med Res, Bangkok 10400, Thailand. [Sirivisoot, Sirintra] Chulalongkorn Univ, Fac Vet Sci, Dept Pathol, Bangkok 10330, Thailand. RP Lombardini, ED (reprint author), Armed Forces Res Inst Med Sci, Div Comparat Pathol, Bangkok 10400, Thailand. EM Lombardinied@afrims.org NR 12 TC 0 Z9 0 U1 1 U2 1 PU CHULALONGKORN UNIV PI BANGKOK PA FAC VETERINARY SCI, HENRI DUNANT RD, BANGKOK, 10330, THAILAND SN 0125-6491 J9 THAI J VET MED JI Thai J. Vet. Med. PD SEP PY 2014 VL 44 IS 3 BP 385 EP 390 PG 6 WC Veterinary Sciences SC Veterinary Sciences GA AR8WA UT WOS:000343851000012 ER PT J AU Kragh, JF Steinbaugh, J Parsons, DL Mabry, RL Kheirabadi, BS Dubick, MA AF Kragh, John F., Jr. Steinbaugh, John Parsons, Donald L. Mabry, Robert L. Kheirabadi, Bijan S. Dubick, Michael A. TI A manikin model for study of wound-packing interventions to control out-of-hospital hemorrhage SO AMERICAN JOURNAL OF EMERGENCY MEDICINE LA English DT Letter ID COMBAT CASUALTY CARE; EFFICACY; SWINE C1 [Kragh, John F., Jr.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Kragh, John F., Jr.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med Bethesda, Bethesda, MD 20814 USA. [Steinbaugh, John] RevMedx Inc, Wilsonville, OR USA. [Parsons, Donald L.] US Army, Med Dept Ctr, Combat Medic Training, Ft Sam Houston, TX USA. [Parsons, Donald L.] Sch Joint Base San Antonio, Ft Sam Houston, TX USA. [Mabry, Robert L.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. [Kheirabadi, Bijan S.; Dubick, Michael A.] US Army, Inst Surg Res, Damage Control Resuscitat, Ft Sam Houston, TX 78234 USA. RP Kragh, JF (reprint author), US Army, Inst Surg Res, Damage Control Resuscitat, 3698 Chambers Pass Ste B, Ft Sam Houston, TX 78234 USA. EM john.f.kragh.civ@mail.mil NR 8 TC 0 Z9 0 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0735-6757 EI 1532-8171 J9 AM J EMERG MED JI Am. J. Emerg. Med. PD SEP PY 2014 VL 32 IS 9 BP 1130 EP 1131 DI 10.1016/j.ajem.2014.05.020 PG 3 WC Emergency Medicine SC Emergency Medicine GA AR1AY UT WOS:000343312600042 PM 24976606 ER PT J AU Fischer, AH Schwartz, MR Moriarty, AT Wilbur, DC Souers, R Fatheree, L Booth, CN Clayton, AC Kurtyz, DFI Padmanabhan, V Crothers, BA AF Fischer, Andrew H. Schwartz, Mary R. Moriarty, Ann T. Wilbur, David C. Souers, Rhona Fatheree, Lisa Booth, Christine N. Clayton, Amy C. Kurtyz, Daniel F. I. Padmanabhan, Vijayalakshmi Crothers, Barbara A. TI Immunohistochemistry Practices of Cytopathology Laboratories A Survey of Participants in the College of American Pathologists Nongynecologic Cytopathology Education Program SO ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE LA English DT Article ID TRANSFERRED CYTOLOGIC SPECIMENS; COMMONLY USED IMMUNOSTAINS; AUTOMATED CELL BLOCK; BREAST-CANCER; CLINICAL-ONCOLOGY/COLLEGE; GUIDELINE RECOMMENDATIONS; IMMUNOCYTOCHEMISTRY; VALIDATION; PROGESTERONE; ESTROGEN AB Context.-Immunohistochemistry (IHC) is important for cytology but poses special challenges because preanalytic conditions may differ from the conditions of IHC-positive controls. Objectives.-To broadly survey cytology laboratories to quantify preanalytic platforms for cytology IHC and identify problems with particular platforms or antigens. To discover how validation guidelines for HER2 testing have affected cytology. Design.-A voluntary survey of cytology IHC practices was sent to 1899 cytology laboratories participating in the College of American Pathologists Nongynecologic Cytopathology Education Program in the fall of 2009. Results.-A total of 818 laboratories (43%) responded to the survey by April 2010. Three hundred fourty-five of 791 respondents (44%) performed IHC on cytology specimens. Seventeen different fixation and processing platforms prior to antibody reaction were reported. A total of 59.2% of laboratories reported differences between the platforms for cytology specimens and positive controls, but most (155 of 184; 84%) did not alter antibody dilutions or antigen retrieval for cytology IHC. When asked to name 2 antibodies for which staining conditions differed between cytology and surgical samples, there were 18 responses listing 14 antibodies. A total of 30.6% of laboratories performing IHC offered HER2 testing before publication of the 2007 College of American Pathologists/American Society of Clinical Oncologists guidelines, compared with 33.6% afterward, with increased performance of testing by reference laboratories. Three laboratories validated a nonformalin HER2 platform. Conclusions.-The platforms for cytology IHC and positive controls differ for most laboratories, yet conditions are uncommonly adjusted for cytology specimens. Except for the unsuitability of air-dried smears for HER2 testing, the survey did not reveal evidence of systematic problems with any antibody or platform. C1 [Fischer, Andrew H.] Univ Massachusetts Mem Hlth Care, Dept Pathol, Worcester, MA 01605 USA. [Schwartz, Mary R.] Methodist Hosp, Dept Pathol & Genom Med, Houston, TX 77030 USA. [Moriarty, Ann T.] AmeriPath Indiana, Dept Pathol, Indianapolis, IN USA. [Wilbur, David C.] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA. [Souers, Rhona] Coll Amer Pathologists, Dept Stat Biostat, Northfield, IL USA. [Fatheree, Lisa] Coll Amer Pathologists, Dept Cytol Surveys, Northfield, IL USA. [Booth, Christine N.] Cleveland Clin Fdn, Dept Anat Pathol, Cleveland, OH 44195 USA. [Clayton, Amy C.] Mayo Clin, Dept Anat Pathol, Rochester, MN USA. [Kurtyz, Daniel F. I.] Wisconsin State Lab Hyg, Dept Cytol, Madison, WI USA. [Padmanabhan, Vijayalakshmi] Dartmouth Hitchcock Med Ctr, Dept Pathol, Lebanon, NH 03766 USA. [Crothers, Barbara A.] Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. [Crothers, Barbara A.] Walter Reed Army Med Ctr, Area Lab Serv, Washington, DC 20307 USA. RP Fischer, AH (reprint author), Univ Massachusetts Mem Hlth Care, Dept Pathol, 1 Innovat Dr, Worcester, MA 01605 USA. EM Fischa01@ummhc.org OI Fischer, Andrew/0000-0002-5944-4621 FU Hologic, Inc FX Dr Fischer is an inventor of the Cellient Automated Cell Block System, licensed to Hologic, Inc, and he receives royalties for sales of this technology. The other authors have no relevant financial interest in the products or companies described in this article. NR 27 TC 5 Z9 6 U1 1 U2 3 PU COLL AMER PATHOLOGISTS PI NORTHFIELD PA C/O KIMBERLY GACKI, 325 WAUKEGAN RD, NORTHFIELD, IL 60093-2750 USA SN 0003-9985 EI 1543-2165 J9 ARCH PATHOL LAB MED JI Arch. Pathol. Lab. Med. PD SEP PY 2014 VL 138 IS 9 BP 1167 EP 1172 DI 10.5858/arpa.2013-0259-CP PG 6 WC Medical Laboratory Technology; Medicine, Research & Experimental; Pathology SC Medical Laboratory Technology; Research & Experimental Medicine; Pathology GA AR5PI UT WOS:000343635800007 PM 24840035 ER PT J AU Hoge, CW Riviere, LA Wilk, JE Herrell, RK Weathers, FW AF Hoge, Charles W. Riviere, Lyndon A. Wilk, Joshua E. Herrell, Richard K. Weathers, Frank W. TI The prevalence of post-traumatic stress disorder (PTSD) in US combat soldiers: a head-to-head comparison of DSM-5 versus DSM-IV-TR symptom criteria with the PTSD checklist SO LANCET PSYCHIATRY LA English DT Article ID MENTAL-HEALTH PROBLEMS; NONCLINICAL SAMPLE; FUNCTIONAL IMPAIRMENT; PRIMARY-CARE; IRAQ; POPULATION; AFGHANISTAN; SCALE AB Background The definition of post-traumatic stress disorder (PTSD) underwent substantial changes in the 2013 edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). How this will affect estimates of prevalence, whether clinical utility has been improved, and how many individuals who meet symptom criteria according to the previous definition will not meet new criteria is unknown. Updated screening instruments, including the PTSD checklist (PCL), have not been compared with previously validated methods through head-to-head comparisons. Methods We compared the new 20-item PCL, mapped to DSM-5 (PCL-5), with the original validated 17-item specific stressor version (PCL-S) in 1822 US infantry soldiers, including 946 soldiers who had been deployed to Iraq or Afghanistan. Surveys were administered in November, 2013. Soldiers alternately received either of two surveys that were identical except for the order of the two PCL versions (911 per group). Standardised scales measured major depression, generalised anxiety, alcohol misuse, and functional impairment. Results In analysis of all soldiers, 224 (13%) screened positive for PTSD by DSM-IV-TR criteria and 216 (12%) screened positive by DSM-5 criteria (kappa 0.67). In soldiers exposed to combat, 177 (19%) screened positive by DSM-IV-TR and 165 (18%) screened positive by DSM-5 criteria (0.66). However, of 221 soldiers with complete data who met DSM-IV-TR criteria, 67 (30%) did not meet DSM-5 criteria, and 59 additional soldiers met only DSM-5 criteria. PCL-5 scores from 15-38 performed similarly to PCL-S scores of 30-50; a PCL-5 score of 38 gave optimum agreement with a PCL-S of 50. The two definitions showed nearly identical association with other psychiatric disorders and functional impairment. Conclusions Our findings showed the PCL-5 to be equivalent to the validated PCL-S. However, the new PTSD symptom criteria do not seem to have greater clinical utility, and a high percentage of soldiers who met criteria by one definition did not meet the other criteria. Clinicians need to consider how to manage discordant outcomes, particularly for service members and veterans with PTSD who no longer meet criteria under DSM-5. C1 [Hoge, Charles W.; Riviere, Lyndon A.; Wilk, Joshua E.; Herrell, Richard K.] Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Weathers, Frank W.] Auburn Univ, Dept Psychol, Auburn, AL 36849 USA. RP Hoge, CW (reprint author), Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD 20910 USA. EM charles.hoge@us.army.mil FU US Army Military Operational Medicine Research Program (MOMRP), Fort Detrick, MD FX US Army Military Operational Medicine Research Program (MOMRP), Fort Detrick, MD. NR 34 TC 50 Z9 52 U1 9 U2 44 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 2215-0374 J9 LANCET PSYCHIAT JI Lancet Psychiatry PD SEP PY 2014 VL 1 IS 4 BP 269 EP 277 DI 10.1016/S2215-0366(14)70235-4 PG 9 WC Psychiatry SC Psychiatry GA AR6OW UT WOS:000343703800029 PM 26360860 ER PT J AU Martin, G AF Martin, Grant TI Zero dark squared: Does the US benefit from more Special Operations Forces? SO INTERNATIONAL JOURNAL LA English DT Article DE Special operations; special warfare; surgical strike; asymmetric threats; unconventional warfare; SOCOM; global SOF network AB There is no question that the number of United States Special Operations Forces (SOF) is growing. This paper argues that focusing on the increase in size obscures what should be the real debate: what kind of SOF should the US employ in the twenty-first century? I conclude with two ideas: that SOF's best capability is at the tactical level, and that the largest benefit they can provide a democracy is in the conduct of special warfare, and not the more popular surgical strike operations. It would be wise, therefore, for democracies to resist the natural inclination to grow SOF simply because they perceive a growth in asymmetric threats. SOF, conducting special warfare, can offer democracies both a "special'' capability and also more subtle, longer-term influence than is normally associated with conventional armed forces. RP Martin, G (reprint author), US Army JFK Special Warfare Ctr & Sch, ARSOCIC, 3004 Ardennes St, Ft Bragg, NC 28310 USA. EM Gmartinrtt1@gmail.com NR 4 TC 0 Z9 0 U1 1 U2 4 PU CANADIAN INST INT AFFAIRS PI TORONTO PA 205 RICHMOND STREET WEST, STE 302, TORONTO, ONTARIO M5V 1V3, CANADA SN 0020-7020 EI 2052-465X J9 INT J JI Int. J. PD SEP PY 2014 VL 69 IS 3 BP 413 EP 421 DI 10.1177/0020702014539279 PG 9 WC International Relations SC International Relations GA AQ8JH UT WOS:000343071300008 ER PT J AU Metz, S AF Metz, Steven TI The Modern American Military SO JOURNAL OF AMERICAN HISTORY LA English DT Book Review C1 [Metz, Steven] US Army, War Coll, Carlisle, PA 17013 USA. RP Metz, S (reprint author), US Army, War Coll, Carlisle, PA 17013 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ORGANIZATION AMER HISTORIANS PI BLOOMINGTON PA 112 N BRYAN ST, BLOOMINGTON, IN 47408 USA SN 0021-8723 EI 1945-2314 J9 J AM HIST JI J. Am. Hist. PD SEP PY 2014 VL 101 IS 2 BP 672 EP 673 DI 10.1093/jahist/jau491 PG 3 WC History SC History GA AQ7KN UT WOS:000342993600154 ER PT J AU Meitzler, T Ebenstein, S Bankowski, E AF Meitzler, Thomas Ebenstein, Samuel Bankowski, Elena TI A New Paradigm for Nondestructive Testing SO MATERIALS EVALUATION LA English DT Article DE armor health monitoring; ultrasonics; optics; embedded systems AB Two approaches for embedded health monitoring in armor are discussed. One technique involves using embedded piezoelectric transducers; the other technique uses light-emitting diodes and phototransistors are used to transmit and receive, respectively, light of a certain wavelength transmitted through the armor material. C1 [Meitzler, Thomas; Bankowski, Elena] US Army RDECOM TARDEC, RDTA RS, Warren, MI 48397 USA. [Ebenstein, Samuel] Booz Allen Hamilton, RDTA RS, Warren, MI 48397 USA. RP Meitzler, T (reprint author), US Army RDECOM TARDEC, RDTA RS, 6501 E 11 Mile Rd, Warren, MI 48397 USA. EM thomas.j.meitzler.civ@mail.mil RI Meitzler, Thomas/D-1065-2017 NR 4 TC 0 Z9 0 U1 0 U2 4 PU AMER SOC NONDESTRUCTIVE TEST PI COLUMBUS PA 1711 ARLINGATE LANE PO BOX 28518, COLUMBUS, OH 43228-0518 USA SN 0025-5327 J9 MATER EVAL JI Mater. Eval. PD SEP PY 2014 VL 72 IS 9 BP 1138 EP 1145 PG 8 WC Materials Science, Characterization & Testing SC Materials Science GA AR1HH UT WOS:000343335800005 ER PT J AU Terrill, WA AF Terrill, W. Andrew TI The First World War in the Middle East SO MIDDLE EAST JOURNAL LA English DT Book Review C1 [Terrill, W. Andrew] US Army War Coll, Strateg Studies Inst, Carlisle, PA 17013 USA. RP Terrill, WA (reprint author), US Army War Coll, Strateg Studies Inst, Carlisle, PA 17013 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU MIDDLE EAST INST PI WASHINGTON PA 1761 N ST NW, CIRCULATION DEPT, WASHINGTON, DC 20036-2882 USA SN 0026-3141 EI 1940-3461 J9 MIDDLE EAST J JI Middle East J. PD FAL PY 2014 VL 68 IS 4 BP 657 EP 659 PG 3 WC Area Studies SC Area Studies GA AR0OD UT WOS:000343270300023 ER PT J AU Ruediger, TM Allison, SC Moore, JM Wainner, RS AF Ruediger, T. M. Allison, S. C. Moore, J. M. Wainner, R. S. TI Reliability, reference values and predictor variables of the ulnar sensory nerve in disease free adults SO NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY LA English DT Article DE Ulnar sensory; Reference values; Reliability; Nerve conduction ID CUBITAL TUNNEL-SYNDROME; ELECTRODIAGNOSTIC MEDICINE; CONDUCTION TECHNIQUE; ELBOW; NEUROPATHY; MINIMONOGRAPH; DECOMPRESSION; DIAGNOSIS; LESIONS AB Objective. -The purposes of this descriptive and exploratory study were to examine electrophysiological measures of ulnar sensory nerve function in disease free adults to determine reliability, determine reference values computed with appropriate statistical methods, and examine predictive ability of anthropometric variables. Methods. -Antidromic sensory nerve conduction studies of the ulna!: nerve using surface electrodes were performed on 100 volunteers. Reference values were computed from optimally transformed data. Reliability was computed from 30 subjects. Multiple linear regression models were constructed from four predictor variables. Results. -Reliability was greater than 0.85 for all paired measures. Responses were elicited in all subjects; reference values for sensory nerve action potential (SNAP) amplitude from above elbow stimulation are 3.3 mu V and decrement across-elbow less than 46%. No single predictor variable accounted for more than 15% of the variance in the response. Conclusion. -Electrophysiologic measures of the ulnar sensory nerve are reliable. Absent SNAP responses are inconsistent with disease free individuals. Reference values recommended in this report are based on appropriate transformations of non-normally distributed data. No strong statistical model of prediction could be derived from the limited set of predictor variables. Significance. -Reliability analyses combined with relatively low level of measurement error suggest that ulnar sensory reference values may be used with confidence. (C) 2014 Elsevier Masson SAS. All rights reserved. C1 [Ruediger, T. M.] Trine Univ, Ft Wayne, IN 46825 USA. [Allison, S. C.] Rocky Mt Univ Hlth Profess, Provo, UT USA. [Allison, S. C.] Baylor Univ, San Antonio, TX USA. [Allison, S. C.] US Army Res Inst Environm Med, Natick, MA USA. [Moore, J. M.] Grad Sch Acad Hlth Sci Ft Sam Houston, Houston, TX USA. [Wainner, R. S.] Texas State Univ, Boerne, TX USA. RP Ruediger, TM (reprint author), Trine Univ, Ft Wayne, IN 46825 USA. EM ruedigert@trine.edu NR 24 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER PI PARIS PA 23 RUE LINOIS, 75724 PARIS, FRANCE SN 0987-7053 EI 1769-7131 J9 NEUROPHYSIOL CLIN JI Neurophysiol. Clin.-Clin. Neurophysiol. PD SEP PY 2014 VL 44 IS 3 BP 281 EP 289 DI 10.1016/j.neucli.2014.04.005 PG 9 WC Clinical Neurology; Neurosciences; Physiology SC Neurosciences & Neurology; Physiology GA AR1WS UT WOS:000343375900006 PM 25240561 ER PT J AU Gross, J Savant, A AF Gross, Jane Savant, Adrienne TI OVERCOMING BARRIERS TO INFECTION CONTROL IN PATIENTS WITH CF SO PEDIATRIC PULMONOLOGY LA English DT Meeting Abstract ID CYSTIC-FIBROSIS; CONTROL GUIDELINES C1 [Gross, Jane] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Savant, Adrienne] Childrens Hosp Chicago, Chicago, IL USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 8755-6863 EI 1099-0496 J9 PEDIATR PULM JI Pediatr. Pulmonol. PD SEP PY 2014 VL 49 SU 38 MA S18.4 BP 199 EP 200 PG 2 WC Pediatrics; Respiratory System SC Pediatrics; Respiratory System GA AQ6MD UT WOS:000342926000072 ER PT J AU Lambert, PK Hustedt, CJ Vecchio, KS Huskins, EL Casem, DT Gruner, SM Tate, MW Philipp, HT Woll, AR Purohit, P Weiss, JT Kannan, V Ramesh, KT Kenesei, P Okasinski, JS Almer, J Zhao, M Ananiadis, AG Hufnagel, TC AF Lambert, P. K. Hustedt, C. J. Vecchio, K. S. Huskins, E. L. Casem, D. T. Gruner, S. M. Tate, M. W. Philipp, H. T. Woll, A. R. Purohit, P. Weiss, J. T. Kannan, V. Ramesh, K. T. Kenesei, P. Okasinski, J. S. Almer, J. Zhao, M. Ananiadis, A. G. Hufnagel, T. C. TI Time-resolved x-ray diffraction techniques for bulk polycrystalline materials under dynamic loading SO REVIEW OF SCIENTIFIC INSTRUMENTS LA English DT Article ID DEFORMATION; COMPRESSION; TITANIUM; DETECTOR; STRAINS AB We have developed two techniques for time-resolved x-ray diffraction from bulk polycrystalline materials during dynamic loading. In the first technique, we synchronize a fast detector with loading of samples at strain rates of similar to 10(3)-10(4) s(-1) in a compression Kolsky bar (split Hopkinson pressure bar) apparatus to obtain in situ diffraction patterns with exposures as short as 70 ns. This approach employs moderate x-ray energies (10-20 keV) and is well suited to weakly absorbing materials such as magnesium alloys. The second technique is useful for more strongly absorbing materials, and uses high-energy x-rays (86 keV) and a fast shutter synchronized with the Kolsky bar to produce short (similar to 40 mu s) pulses timed with the arrival of the strain pulse at the specimen, recording the diffraction pattern on a large-format amorphous silicon detector. For both techniques we present sample data demonstrating the ability of these techniques to characterize elastic strains and polycrystalline texture as a function of time during high-rate deformation. (C) 2014 AIP Publishing LLC. C1 [Lambert, P. K.; Hustedt, C. J.; Zhao, M.; Ananiadis, A. G.; Hufnagel, T. C.] Johns Hopkins Univ, Dept Mat Sci & Engn, Baltimore, MD 21218 USA. [Vecchio, K. S.] Univ Calif San Diego, Dept NanoEngn, La Jolla, CA 92093 USA. [Huskins, E. L.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37830 USA. [Huskins, E. L.; Casem, D. T.] US Army Res Lab, Aberdeen, MD 21005 USA. [Gruner, S. M.; Tate, M. W.; Philipp, H. T.; Purohit, P.; Weiss, J. T.] Cornell Univ, Dept Phys, Ithaca, NY 14853 USA. [Gruner, S. M.; Woll, A. R.] Cornell Univ, CHESS, Ithaca, NY 14853 USA. [Gruner, S. M.] Cornell Univ, Kavli Inst Cornell Nanoscale Sci, Ithaca, NY 14853 USA. [Kannan, V.; Ramesh, K. T.] Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. [Kenesei, P.; Okasinski, J. S.; Almer, J.] Argonne Natl Lab, Xray Sci Div, Argonne, IL 60439 USA. RP Lambert, PK (reprint author), Johns Hopkins Univ, Dept Mat Sci & Engn, Baltimore, MD 21218 USA. RI Hufnagel, Todd/A-3309-2010 OI Hufnagel, Todd/0000-0002-6373-9377 FU Army Research Laboratory; US Navy under MURI Program [ONR MURI N00014-61007-1-0740]; U.S. DOE [DE-AC02-06CH11357]; OSD-T& E (Office of Secretary Defense-Test and Evaluation), Defense-Wide National Defense Education Program (NDEP)/BA-1, Basic Research [PE0601120D8Z]; DOE [DE-FG02-10ER46693]; Keck Foundation; CHESS; NSF; NIH-NIGMS under NSF [DMR-0936384]; [W911NF-12-2-0022] FX The authors would like to acknowledge A. Mashayekhi, L. Zhou, and K. Goetze for their contributions to this work. This work was sponsored in part by the Army Research Laboratory and was accomplished under Cooperative Agreement No. W911NF-12-2-0022. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for government purposes notwithstanding any copyright notation herein. Financial support for this work was also provided by the US Navy under the MURI Program (Grant ONR MURI N00014-61007-1-0740). Use of the Advanced Photon Source, an Office of Science User Facility operated for the U.S. Department of Energy (DOE) Office of Science by Argonne National Laboratory, was supported by the U.S. DOE under Contract No. DE-AC02-06CH11357. P. K. L. would like to acknowledge OSD-T& E (Office of Secretary Defense-Test and Evaluation), Defense-Wide/PE0601120D8Z National Defense Education Program (NDEP)/BA-1, Basic Research, for their support. Detector development at Cornell is supported by the DOE Grant No. DE-FG02-10ER46693, the Keck Foundation, and CHESS. CHESS is supported by the NSF and NIH-NIGMS under NSF Grant No. DMR-0936384. NR 28 TC 6 Z9 6 U1 14 U2 49 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0034-6748 EI 1089-7623 J9 REV SCI INSTRUM JI Rev. Sci. Instrum. PD SEP PY 2014 VL 85 IS 9 AR 093901 DI 10.1063/1.4893881 PG 7 WC Instruments & Instrumentation; Physics, Applied SC Instruments & Instrumentation; Physics GA AQ6HE UT WOS:000342910500034 PM 25273733 ER PT J AU Wilbanks, MS Gust, KA Atwa, S Sunesara, I Johnson, D Ang, CY Meyer, SA Perkins, EJ AF Wilbanks, Mitchell S. Gust, Kurt A. Atwa, Sahar Sunesara, Imran Johnson, David Ang, Choo Yaw Meyer, Sharon A. Perkins, Edward J. TI Validation of a Genomics-Based Hypothetical Adverse Outcome Pathway: 2,4-Dinitrotoluene Perturbs PPAR Signaling Thus Impairing Energy Metabolism and Exercise Endurance SO TOXICOLOGICAL SCIENCES LA English DT Article DE dinitrotoluene; energy; adverse outcome pathway; PPAR ID PROLIFERATOR-ACTIVATED RECEPTORS; NORTHERN BOBWHITE; CHRONIC TOXICITY; GENE-EXPRESSION; FATTY-ACIDS; MICE; ALPHA; RATS; EXPOSURE; BINDING AB 2,4-dinitrotoluene (2,4-DNT) is a nitroaromatic used in industrial dyes and explosives manufacturing processes that is found as a contaminant in the environment. Previous studies have implicated antagonism of PPAR alpha signaling as a principal process affected by 2,4-DNT. Here, we test the hypothesis that 2,4-DNT-induced perturbations in PPAR alpha signaling and resultant downstream deficits in energy metabolism, especially from lipids, cause organism-level impacts on exercise endurance. PPAR nuclear activation bioassays demonstrated inhibition of PPAR alpha signaling by 2,4-DNT whereas PPAR alpha signaling increased. PPAR alpha (-/-) and wild-type (WT) female mice were exposed for 14 days to vehicle or 2,4-DNT (134 mg/kg/day) and performed a forced swim to exhaustion 1 day after the last dose. 2,4-DNT significantly decreased body weights and swim times in WTs, but effects were significantly mitigated in PPAR alpha (-/-) mice. 2,4-DNT decreased transcript expression for genes downstream in the PPAR alpha signaling pathway, principally genes involved in fatty acid transport. Results indicate that PPAR alpha signaling increased resulting in enhanced cycling of lipid and carbohydrate substrates into glycolytic/gluconeogenic pathways favoring energy production versus storage in 2,4-DNT-exposed WT and PPAR alpha (-/-) mice. PPAR alpha (-/-) mice appear to have compensated for the loss of PPAR alpha by shifting energy metabolism to PPAR alpha-independent pathways resulting in lower sensitivity to 2,4-DNT when compared with WT mice. Our results validate 2,4-DNT-induced perturbation of PPAR alpha signaling as the molecular initiating event for impaired energy metabolism, weight loss, and decreased exercise performance. C1 [Wilbanks, Mitchell S.; Gust, Kurt A.; Johnson, David; Perkins, Edward J.] Army Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Atwa, Sahar; Meyer, Sharon A.] Univ Louisiana, Monroe, LA 71201 USA. [Sunesara, Imran] Univ Mississippi, Med Ctr, Jackson, MS 39216 USA. [Johnson, David] Conestoga Rovers & Associates, Dallas, TX 75234 USA. [Ang, Choo Yaw] Badger Tech Serv, San Antonio, TX USA. RP Wilbanks, MS (reprint author), US Army, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM mitchell.s.wilbanks@usace.army.mil FU U.S. Army Environmental Quality and Installations applied research program FX U.S. Army Environmental Quality and Installations applied research program. Permission was granted by the Chief of the U.S. Army Corps of Engineers to publish this information. NR 54 TC 4 Z9 4 U1 1 U2 9 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD SEP PY 2014 VL 141 IS 1 BP 44 EP 58 DI 10.1093/toxsci/kfu104 PG 15 WC Toxicology SC Toxicology GA AQ7JP UT WOS:000342990200010 PM 24893713 ER PT J AU Kuhn, JH Andersen, KG Bao, YM Bavari, S Becker, S Bennett, RS Bergman, NH Blinkova, O Bradfute, S Brister, JR Bukreyev, A Chandran, K Chepurnov, AA Davey, RA Dietzgen, RG Doggett, NA Dolnik, O Dye, JM Enterlein, S Fenimore, PW Formenty, P Freiberg, AN Garry, RF Garza, NL Gire, SK Gonzalez, JP Griffiths, A Happi, CT Hensley, LE Herbert, AS Hevey, MC Hoenen, T Honko, AN Ignatyev, GM Jahrling, PB Johnson, JC Johnson, KM Kindrachuk, J Klenk, HD Kobinger, G Kochel, TJ Lackemeyer, MG Lackner, DF Leroy, EM Lever, MS Muhlberger, E Netesov, SV Olinger, GG Omilabu, SA Palacios, G Panchal, RG Park, DJ Patterson, JL Paweska, JT Peters, CJ Pettitt, J Pitt, L Radoshitzky, SR Ryabchikova, EI Saphire, EO Sabeti, PC Sealfon, R Shestopalov, AM Smither, SJ Sullivan, NJ Swanepoel, R Takada, A Towner, JS van der Groen, G Volchkov, VE Volchkova, VA Wahl-Jensen, V Warren, TK Warfield, KL Weidmann, M Nichol, ST AF Kuhn, Jens H. Andersen, Kristian G. Bao, Yiming Bavari, Sina Becker, Stephan Bennett, Richard S. Bergman, Nicholas H. Blinkova, Olga Bradfute, Steven Brister, J. Rodney Bukreyev, Alexander Chandran, Kartik Chepurnov, Alexander A. Davey, Robert A. Dietzgen, Ralf G. Doggett, Norman A. Dolnik, Olga Dye, John M. Enterlein, Sven Fenimore, Paul W. Formenty, Pierre Freiberg, Alexander N. Garry, Robert F. Garza, Nicole L. Gire, Stephen K. Gonzalez, Jean-Paul Griffiths, Anthony Happi, Christian T. Hensley, Lisa E. Herbert, Andrew S. Hevey, Michael C. Hoenen, Thomas Honko, Anna N. Ignatyev, Georgy M. Jahrling, Peter B. Johnson, Joshua C. Johnson, Karl M. Kindrachuk, Jason Klenk, Hans-Dieter Kobinger, Gary Kochel, Tadeusz J. Lackemeyer, Matthew G. Lackner, Daniel F. Leroy, Eric M. Lever, Mark S. Muehlberger, Elke Netesov, Sergey V. Olinger, Gene G. Omilabu, Sunday A. Palacios, Gustavo Panchal, Rekha G. Park, Daniel J. Patterson, Jean L. Paweska, Janusz T. Peters, Clarence J. Pettitt, James Pitt, Louise Radoshitzky, Sheli R. Ryabchikova, Elena I. Saphire, Erica Ollmann Sabeti, Pardis C. Sealfon, Rachel Shestopalov, Aleksandr M. Smither, Sophie J. Sullivan, Nancy J. Swanepoel, Robert Takada, Ayato Towner, Jonathan S. van der Groen, Guido Volchkov, Viktor E. Volchkova, Valentina A. Wahl-Jensen, Victoria Warren, Travis K. Warfield, Kelly L. Weidmann, Manfred Nichol, Stuart T. TI Filovirus RefSeq Entries: Evaluation and Selection of Filovirus Type Variants, Type Sequences, and Names SO VIRUSES-BASEL LA English DT Letter DE Bundibugyo virus; cDNA clone; cuevavirus; Ebola; Ebola virus; ebolavirus; filovirid; Filoviridae; filovirus; genome annotation; ICTV; International Committee on Taxonomy of Viruses; Lloviu virus; Marburg virus; marburgvirus; mononegavirad; Mononegavirales; mononegavirus; Ravn virus; RefSeq; Reston virus; reverse genetics; Sudan virus; Tai Forest virus; virus classification; virus isolate; virus nomenclature; virus strain; virus taxonomy; virus variant ID INTERFERON INHIBITORY DOMAIN; DOUBLE-STRANDED-RNA; C-TERMINAL DOMAIN; EBOLA-VIRUS VP35; STANDARDIZED NOMENCLATURE; FAMILY FILOVIRIDAE; SPECIES LEVEL; INTERNATIONAL COMMITTEE; ENVELOPE GLYCOPROTEIN; TAXONOMIC PROPOSALS AB Sequence determination of complete or coding-complete genomes of viruses is becoming common practice for supporting the work of epidemiologists, ecologists, virologists, and taxonomists. Sequencing duration and costs are rapidly decreasing, sequencing hardware is under modification for use by non-experts, and software is constantly being improved to simplify sequence data management and analysis. Thus, analysis of virus disease outbreaks on the molecular level is now feasible, including characterization of the evolution of individual virus populations in single patients over time. The increasing accumulation of sequencing data creates a management problem for the curators of commonly used sequence databases and an entry retrieval problem for end users. Therefore, utilizing the data to their fullest potential will require setting nomenclature and annotation standards for virus isolates and associated genomic sequences. The National Center for Biotechnology Information's (NCBI's) RefSeq is a non-redundant, curated database for reference (or type) nucleotide sequence records that supplies source data to numerous other databases. Building on recently proposed templates for filovirus variant naming [ ()////-], we report consensus decisions from a majority of past and currently active filovirus experts on the eight filovirus type variants and isolates to be represented in RefSeq, their final designations, and their associated sequences. C1 [Kuhn, Jens H.; Hensley, Lisa E.; Honko, Anna N.; Jahrling, Peter B.; Johnson, Joshua C.; Kindrachuk, Jason; Lackemeyer, Matthew G.; Olinger, Gene G.; Pettitt, James] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD 21702 USA. [Andersen, Kristian G.; Gire, Stephen K.; Sabeti, Pardis C.] Harvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA. [Bao, Yiming; Blinkova, Olga; Brister, J. Rodney] Natl Lib Med, Informat Engn Branch, Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20894 USA. [Bavari, Sina; Dye, John M.; Garza, Nicole L.; Herbert, Andrew S.; Palacios, Gustavo; Panchal, Rekha G.; Pitt, Louise; Radoshitzky, Sheli R.; Warren, Travis K.] US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Becker, Stephan; Dolnik, Olga; Klenk, Hans-Dieter] Univ Marburg, Inst Virol, D-35043 Marburg, Germany. [Bennett, Richard S.; Bergman, Nicholas H.; Hevey, Michael C.; Kochel, Tadeusz J.; Lackner, Daniel F.; Wahl-Jensen, Victoria] Natl Biodef Anal & Countermeasures Ctr, Frederick, MD 21702 USA. [Bradfute, Steven] Univ New Mexico, Albuquerque, NM 87131 USA. [Bukreyev, Alexander; Freiberg, Alexander N.; Peters, Clarence J.] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA. [Bukreyev, Alexander; Freiberg, Alexander N.; Peters, Clarence J.] Univ Texas Med Branch, Galveston Natl Lab, Galveston, TX 77555 USA. [Chandran, Kartik] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA. [Chepurnov, Alexander A.] Russian Acad Sci, Siberian Branch, Inst Clin Immunol, Novosibirsk 630091, Novosibirsk Obl, Russia. [Davey, Robert A.; Griffiths, Anthony; Patterson, Jean L.] Texas Biomed Res Inst, Dept Virol & Immunol, San Antonio, TX 78227 USA. [Dietzgen, Ralf G.] Univ Queensland, Queensland Alliance Agr & Food Innovat, St Lucia, Qld 4072, Australia. [Doggett, Norman A.; Fenimore, Paul W.] Los Alamos Natl Lab, Los Alamos, NM 87545 USA. [Enterlein, Sven] Integrated BioTherapeut Inc, Gaithersburg, MD 20878 USA. [Formenty, Pierre] WHO, CH-1211 Geneva, Switzerland. [Gonzalez, Jean-Paul] Metabiota Inc, San Francisco, CA 94104 USA. [Garry, Robert F.] Tulane Univ, Sch Med, Dept Microbiol & Immunol, New Orleans, LA 70112 USA. [Happi, Christian T.] Redeemers Univ, Dept Biol Sci, Coll Nat Sci, Lagos, Ogun State, Nigeria. [Happi, Christian T.] Redeemers Univ, African Ctr Excellence Genom Infect Dis, Lagos, Ogun State, Nigeria. [Hoenen, Thomas] NIAID, Virol Lab, Div Intramural Res, NIH, Hamilton, MT 59840 USA. [Ignatyev, Georgy M.] Minist Hlth Russian Federat, Microgen Sci Ind Co Immunobiol Med, Fed State Unitary Co, Moscow 115088, Russia. [Kobinger, Gary] Publ Hlth Agcy Canada, Natl Microbiol Lab, Special Pathogens Program, Winnipeg, MB R3E 3R2, Canada. [Leroy, Eric M.] Ctr Int Rech Med Franceville, Franceville, Gabon. [Lever, Mark S.; Smither, Sophie J.] Dstl, Dept Biomed Sci, Salisbury SP4 0JQ, Wilts, England. [Muehlberger, Elke] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA. [Muehlberger, Elke] Boston Univ, Sch Med, Natl Emerging Infect Dis Lab, Boston, MA 02118 USA. [Netesov, Sergey V.; Shestopalov, Aleksandr M.] Novosibirsk State Univ, Novosibirsk 630090, Novosibirsk Reg, Russia. [Omilabu, Sunday A.] Univ Lagos, Coll Med, Dept Med Microbiol & Parasitol, Lagos, Nigeria. [Park, Daniel J.] Broad Inst, Cambridge, MA 02142 USA. [Paweska, Janusz T.] Natl Hlth Lab Serv, Ctr Emerging & Zoonot Dis, Natl Inst Communicable Dis, ZA-2192 Sandringham Johannesburg, Gauteng, South Africa. [Ryabchikova, Elena I.] Russian Acad Sci, Siberian Branch, Inst Chem Biol & Fundamental Med, Novosibirsk 630090, Novosibirsk Reg, Russia. [Saphire, Erica Ollmann] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA. [Saphire, Erica Ollmann] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA. [Sealfon, Rachel] MIT, Cambridge, MA 02139 USA. [Sealfon, Rachel] MIT, Artificial Intelligence Lab, Cambridge, MA 02139 USA. [Sullivan, Nancy J.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. [Swanepoel, Robert] Univ Pretoria, Zoonoses Res Unit, ZA-0028 Pretoria, South Africa. [Takada, Ayato] Hokkaido Univ, Res Ctr Zoonosis Control, Div Global Epidemiol, Kita Ku, Sapporo, Hokkaido, Japan. [Towner, Jonathan S.; Nichol, Stuart T.] Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Div High Consequence Pathogens Pathol, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [van der Groen, Guido] Prins Leopold Inst Trop Geneeskunde, B-2000 Antwerp, Belgium. [Volchkov, Viktor E.; Volchkova, Valentina A.] Univ Lyon 1, INSERM, U1111, Lab Mol Basis Viral Pathogen,CIRI,Ecole Normale S, F-69365 Lyon 07, France. [Warfield, Kelly L.] Unither Virol LLC, Silver Spring, MD 20910 USA. [Weidmann, Manfred] Univ Stirling, Inst Aquaculture, Stirling FK9 4LA, Scotland. RP Kuhn, JH (reprint author), NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD 21702 USA. EM kuhnjens@mail.nih.gov; kandersen@oeb.harvard.edu; bao@ncbi.nlm.nih.gov; sina.bavari.civ@mail.mil; becker@staff.uni-marburg.de; richard.bennett@nbacc.dhs.gov; nicholas.bergman@nbacc.dhs.gov; olga.blinkova@nih.gov; steven_bradfute@yahoo.com; jamesbr@ncbi.nlm.nih.gov; alexander.bukreyev@utmb.edu; kartik.chandran@einstein.yu.edu; alexa.che.purnov@gmail.com; rdavey@txbiomed.org; r.dietzgen@uq.edu.au; doggett@lanl.gov; Dolnik@staff.uni-marburg.de; john.m.dye1.civ@mail.mil; sven.enterlein@gmail.com; paulf@lanl.gov; formentyp@who.int; anfreibe@utmb.edu; rfgarry@tulane.edu; Nicole.l.lackemeyer.ctr@mail.mil; sgire@oeb.harvard.edu; jpgonzalez@metabiota.com; agriffiths@txbiomed.org; chappi@hsph.harvard.edu; lisa.hensley@nih.gov; anderw.s.herbert.ctr@mail.mil; michael.hevey@nbacc.dhs.gov; thomas.hoenen@nih.gov; anna.honko@nih.gov; g.m.ignatyev@microgen.ru; jahrlingp@niaid.nih.gov; joshua.johnson@nih.gov; microcaddis@gmail.com; kindrachuk.kenneth@nih.gov; klenk@mailer.uni-marburg.de; gary.kobinger@phac-aspc.gc.ca; tadeusz.kochel@nbacc.dhs.gov; matthew.lackemeyer@nih.gov; daniel.lackner@nbacc.dhs.gov; eric.leroy@ird.fr; mslever@mail.dstl.gov.uk; muehlber@bu.edu; nauka@nsu.ru; gene.olinger@nih.gov; omilabusa@yahoo.com; gustavo.f.palacios.ctr@us.army.mil; rekha.g.panchal.civ@mail.mil; dpark@broadinstitute.org; jpatters@txbiomed.org; januszp@nicd.ac.za; cjpeters@UTMB.EDU; james.pettitt@nih.gov; louise.pitt@us.army.mil; sheli.r.radoshitzky.ctr@mail.mil; lenryab@yandex.com; erica@scripps.edu; pardis@broadinstitute.org; sealfon@gmail.com; shestopalov2@mail.ru; SJSMITHER@mail.dstl.gov.uk; njsull@mail.nih.gov; bobswanepoel@gmail.com; atakada@czc.hokudai.ac.jp; jit8@cdc.gov; gvdgroen@scarlet.be; viktor.volchkov@inserm.fr; valentina.volchkova@inserm.fr; victoria.jensen@nbacc.dhs.gov; travis.k.warren.ctr@mail.mil; kellylynwarfield@gmail.com; m.w.weidmann@stir.ac.uk; stn1@cdc.gov RI Becker, Stephan/A-1065-2010; Palacios, Gustavo/I-7773-2015; Volchkov, Viktor/M-7846-2014; Weidmann, Manfred/G-1817-2015; LEROY, Eric/I-4347-2016; Kuhn, Jens H./B-7615-2011; Ryabchikova, Elena /G-3089-2013; Netesov, Sergey/A-3751-2013 OI Kindrachuk, Jason/0000-0002-3305-7084; Hoenen, Thomas/0000-0002-5829-6305; Honko, Anna/0000-0001-9165-148X; Becker, Stephan/0000-0002-2794-5659; Palacios, Gustavo/0000-0001-5062-1938; Volchkov, Viktor/0000-0001-7896-8706; Weidmann, Manfred/0000-0002-7063-7491; Johnson, Joshua/0000-0002-5677-3841; Bennett, Richard/0000-0002-7227-4831; LEROY, Eric/0000-0003-0022-0890; Kuhn, Jens H./0000-0002-7800-6045; Ryabchikova, Elena /0000-0003-4714-1524; Netesov, Sergey/0000-0002-7786-2464 FU Intramural NIH HHS; NIAID NIH HHS [HHSN272200700016I, UC7 AI094660, R01 AI104621, U19 AI115589]; World Health Organization [001] NR 49 TC 20 Z9 20 U1 2 U2 32 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1999-4915 J9 VIRUSES-BASEL JI Viruses-Basel PD SEP PY 2014 VL 6 IS 9 BP 3663 EP 3682 DI 10.3390/v6093663 PG 20 WC Virology SC Virology GA AQ8TW UT WOS:000343107100020 PM 25256396 ER PT J AU Faber, I Lane, W Pak, W Prakel, M Rocha, C Farr, JV AF Faber, Isaac Lane, William Pak, Wayne Prakel, Mary Rocha, Cheyne Farr, John V. TI Micro-energy markets: The role of a consumer preference pricing strategy on microgrid energy investment SO ENERGY LA English DT Article; Proceedings Paper CT 26th International Conference on Efficiency, Cost, Optimization, Simulation and Environmental Impact of Energy Systems (ECOS) CY JUL 16-19, 2013 CL Guilin, PEOPLES R CHINA SP Chinese Soc Engn Thermophys DE Energy security; Energy optimization; Energy investment; Energy pricing; Microgrid; Smartgrid ID GENERATION; MANAGEMENT; STANDARD; WORLD AB The fragility of the modern electrical grid is exposed during random events such as storms, sporting events and often simply routine operation. Even with these obvious flaws large utilities and governments have been slow to create robust solutions due to the need of large capital investments required to address the issues. In this light creative economic and engineering solutions are desired to finance the needed upgrades. Driven by the requirement to have uninterrupted power that meets customers desires this research focuses on linking consumer preferences to a type of energy source in order to best fulfill stakeholder priorities. This approach is in contrast to the current and prevalent lowest cost methods to producing and consuming energy. This research yields a preliminary 'micro-energy market' that consists of an energy network architecture, pricing methodology and mathematical template which quantifies potential economic inefficiencies. If exploited these inefficiencies could be used to fund investment into various energy sources that provide unmet needs such as reduced carbon footprint, renewable, quality, and local production. These inefficiencies can be best exploited within the structure of a microgrid. Identification of opportunities on this smaller scale can provide an incentive for producers to develop a robust set of production facilities of varying size and characteristics to meet the consumer preferences. A stochastic optimization model of a microgrid implementation for a small military installation is used to evaluate the effects of this pricing methodology. The energy production of the resulting microgrid would be optimized to meet consumer preferences and minimize economic inefficiency. Published by Elsevier Ltd. C1 [Faber, Isaac; Lane, William; Pak, Wayne; Prakel, Mary; Rocha, Cheyne; Farr, John V.] US Mil Acad, Ctr Nation Reconstruct & Capac Dev, Dept Syst Engn, West Point, NY 10996 USA. RP Faber, I (reprint author), US Mil Acad, Ctr Nation Reconstruct & Capac Dev, Dept Syst Engn, West Point, NY 10996 USA. EM Isaac.faber@usma.edu; john.farr@usma.edu NR 25 TC 2 Z9 2 U1 0 U2 19 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0360-5442 EI 1873-6785 J9 ENERGY JI Energy PD SEP 1 PY 2014 VL 74 BP 567 EP 575 DI 10.1016/j.energy.2014.07.022 PG 9 WC Thermodynamics; Energy & Fuels SC Thermodynamics; Energy & Fuels GA AQ5PW UT WOS:000342862100060 ER PT J AU Staniak, HL Bittencourt, MS Pickett, C Cahill, M Kassop, D Slim, A Blankstein, R Hulten, E AF Staniak, Henrique Lane Bittencourt, Marcio Sommer Pickett, Christopher Cahill, Michael Kassop, David Slim, Ahmad Blankstein, Ron Hulten, Edward TI Coronary CT angiography for acute chest pain in the emergency department SO JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY LA English DT Review DE Chest pain; Coronary computed tomography angiography; Cardiac; Emergency department ID COMPUTED-TOMOGRAPHY ANGIOGRAPHY; INTERNATIONAL MULTICENTER REGISTRY; RANDOMIZED CONTROLLED-TRIAL; ARTERY-DISEASE; PROGNOSTIC VALUE; MYOCARDIAL-INFARCTION; SYMPTOMATIC PATIENTS; RADIATION-EXPOSURE; CLINICAL-OUTCOMES; CARDIAC EVENTS AB Acute chest pain in the emergency department (ED) is a common and costly public health challenge. The traditional strategy of evaluating acute chest pain by hospital or ED observation over a period of several hours, serial electrocardiography and cardiac biomarkers, and subsequent diagnostic testing such as physiologic stress testing is safe and effective. Yet this approach has been criticized for being time intensive and costly. This review evaluates the current medical evidence which has demonstrated the potential for coronary CT angiography (CTA) assessment of acute chest pain to safely reduce ED cost, time to discharge, and rate of hospital admission. These benefits must be weighed against the risk of ionizing radiation exposure and the influence of ED testing on rates of downstream coronary angiography and revascularization. Efforts at radiation minimization have quickly evolved, implementing technology such as prospective electrocardiographic gating and high pitch acquisition to significantly reduce radiation exposure over just a few years. CTA in the ED has demonstrated accuracy, safety, and the ability to reduce ED cost and crowding although its big-picture effect on total hospital and health care system cost extends far beyond the ED. The net effect of CTA is dependent also on the prevalence of coronary artery disease (CAD) in the population where CTA is used which significantly influences rates of post-CTA invasive procedures such as angiography and coronary revascularization. These potential costs and benefits will warrant careful consideration and prospective monitoring as additional hospitals continue to implement this important technology into their diagnostic regimen. Published by Elsevier Inc. on behalf of Society of Cardiovascular Computed Tomography. C1 [Staniak, Henrique Lane; Bittencourt, Marcio Sommer] Univ Sao Paulo, Div Internal Med, Ctr Clin & Epidemiol Res, Sao Paulo, Brazil. [Pickett, Christopher; Cahill, Michael; Kassop, David; Hulten, Edward] Walter Reed Natl Mil Med Ctr, Serv Cardiol, Dept Med, Bethesda, MD 20889 USA. [Pickett, Christopher; Cahill, Michael; Kassop, David; Hulten, Edward] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20889 USA. [Slim, Ahmad] San Antonio Mil Med Ctr, Cardiol Serv MCHE MDC, Brooke Army Med Ctr, San Antonio, TX USA. [Blankstein, Ron] Brigham & Womens Hosp, Dept Med, Div Cardiovasc, Noninvas Cardiovasc Imaging Program, Boston, MA 02115 USA. [Blankstein, Ron] Harvard Univ, Sch Med, Dept Radiol, Boston, MA 02115 USA. RP Hulten, E (reprint author), Walter Reed Natl Mil Med Ctr, Serv Cardiol, Dept Med, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM edward.hulten@us.army.mil RI Bittencourt, Marcio/C-1444-2011 OI Bittencourt, Marcio/0000-0002-3711-1754 NR 42 TC 3 Z9 3 U1 2 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1934-5925 J9 J CARDIOVASC COMPUT JI J. Cardiovasc. Comput. Tomogr. PD SEP-OCT PY 2014 VL 8 IS 5 BP 359 EP 367 DI 10.1016/j.jcct.2014.08.001 PG 9 WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical Imaging SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine & Medical Imaging GA AQ7AI UT WOS:000342964600003 PM 25301041 ER PT J AU Swannack, TM Reif, M Soniat, TM AF Swannack, Todd M. Reif, Molly Soniat, Thomas M. TI A ROBUST, SPATIALLY EXPLICIT MODEL FOR IDENTIFYING OYSTER RESTORATION SITES: CASE STUDIES ON THE ATLANTIC AND GULF COASTS SO JOURNAL OF SHELLFISH RESEARCH LA English DT Article DE eastern oyster; Crassostrea virginica; habitat suitability modeling; spatially explicit; geographic information systems; habitat suitability index ID SUITABILITY INDEX MODELS; CRASSOSTREA-VIRGINICA; HABITAT; REEFS; MANAGEMENT; LOUISIANA; SALINITY AB The eastern oyster (Crassostrea virginica) is a reef-forming organism commonly found in estuaries throughout the Atlantic and Gulf coasts of North America. Eastern oyster reefs provide several ecosystem services, including water filtration, habitat diversity, and storm surge protection, among others. Oyster abundance has declined precipitously during the past century along the Atlantic and Gulf coasts as a result of overfishing, disease and predation, and large-scale human-mediated events. Given the importance of oysters, both ecologically and economically, there have been significant efforts during the past 20 y to reestablish and/or restore oysters to historical levels. Successful reef restoration depends on choosing sites that optimize survival, which requires an understanding of the environmental factors that influence the life stage of an oyster. For most restoration projects, time and budget constraints prevent long-term field studies; therefore, modeling is often used to determine the best locations for restoration. In this study, we developed a spatially explicit, flexible, 4-parameter habitat suitability index model that can be used to determine locations suitable for restoration of eastern oyster reefs throughout the western Atlantic and Gulf coasts. The model captures the minimum environmental parameters required for successful restoration suitability and was applied in 2 studies: (1) Chesapeake Bay, a data rich environment, and (2) northern Gulf of Mexico (western Mississippi Sound), a data poor environment. It illustrates the implications of using data of varying quality when applying the model for identifying restoration potential. In both locations, the model was most sensitive to the presence of appropriate substrate, but not as sensitive to salinity values. This model provides a scientifically based support tool for natural resource managers and project planners, and local conditions may require further consideration. C1 [Swannack, Todd M.; Reif, Molly] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Swannack, Todd M.] Texas State Univ, Dept Biol, San Marcos, TX 78666 USA. [Reif, Molly] US Army Res & Dev Ctr, Joint Airborne Lidar Bathymetry Tech Ctr Expertis, Kiln, MS 39556 USA. [Soniat, Thomas M.] Univ New Orleans, Dept Biol Sci, Oyster Res Lab, New Orleans, LA 70148 USA. [Soniat, Thomas M.] Univ New Orleans, Pontchartrain Inst Environm Sci, New Orleans, LA 70148 USA. RP Swannack, TM (reprint author), US Army Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM todd.m.swannack@usace.army.mil NR 39 TC 2 Z9 2 U1 5 U2 32 PU NATL SHELLFISHERIES ASSOC PI GROTON PA C/O DR. SANDRA E. SHUMWAY, UNIV CONNECTICUT, 1080 SHENNECOSSETT RD, GROTON, CT 06340 USA SN 0730-8000 EI 1943-6319 J9 J SHELLFISH RES JI J. Shellfish Res. PD SEP PY 2014 VL 33 IS 2 BP 395 EP 408 DI 10.2983/035.033.0208 PG 14 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA AQ3LB UT WOS:000342693800007 ER PT J AU Bhoomiboonchoo, P Gibbons, RV Huang, A Yoon, IK Buddhari, D Nisalak, A Chansatiporn, N Thipayamongkolgul, M Kalanarooj, S Endy, T Rothman, AL Srikiatkhachorn, A Green, S Mammen, MP Cummings, DA Salje, H AF Bhoomiboonchoo, Piraya Gibbons, Robert V. Huang, Angkana Yoon, In-Kyu Buddhari, Darunee Nisalak, Ananda Chansatiporn, Natkamol Thipayamongkolgul, Mathuros Kalanarooj, Siripen Endy, Timothy Rothman, Alan L. Srikiatkhachorn, Anon Green, Sharone Mammen, Mammen P. Cummings, Derek A. Salje, Henrik TI The Spatial Dynamics of Dengue Virus in Kamphaeng Phet, Thailand SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID AEDES-AEGYPTI; VIET-NAM; TRANSMISSION; POPULATION; IMMUNITY; CHILDREN; BANGKOK; MODEL AB Background: Dengue is endemic to the rural province of Kamphaeng Phet, Northern Thailand. A decade of prospective cohort studies has provided important insights into the dengue viruses and their generated disease. However, as elsewhere, spatial dynamics of the pathogen remain poorly understood. In particular, the spatial scale of transmission and the scale of clustering are poorly characterized. This information is critical for effective deployment of spatially targeted interventions and for understanding the mechanisms that drive the dispersal of the virus. Methodology/Principal Findings: We geocoded the home locations of 4,768 confirmed dengue cases admitted to the main hospital in Kamphaeng Phet province between 1994 and 2008. We used the phi clustering statistic to characterize short-term spatial dependence between cases. Further, to see if clustering of cases led to similar temporal patterns of disease across villages, we calculated the correlation in the long-term epidemic curves between communities. We found that cases were 2.9 times (95% confidence interval 2.7-3.2) more likely to live in the same village and be infected within the same month than expected given the underlying spatial and temporal distribution of cases. This fell to 1.4 times (1.2-1.7) for individuals living in villages 1 km apart. Significant clustering was observed up to 5 km. We found a steadily decreasing trend in the correlation in epidemics curves by distance: communities separated by up to 5 km had a mean correlation of 0.28 falling to 0.16 for communities separated between 20 km and 25 km. A potential explanation for these patterns is a role for human movement in spreading the pathogen between communities. Gravity style models, which attempt to capture population movement, outperformed competing models in describing the observed correlations. Conclusions: There exists significant short-term clustering of cases within individual villages. Effective spatially and temporally targeted interventions deployed within villages may target ongoing transmission and reduce infection risk. C1 [Bhoomiboonchoo, Piraya; Gibbons, Robert V.; Huang, Angkana; Yoon, In-Kyu; Buddhari, Darunee; Nisalak, Ananda; Mammen, Mammen P.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Bhoomiboonchoo, Piraya; Chansatiporn, Natkamol; Thipayamongkolgul, Mathuros] Mahidol Univ, Fac Publ Hlth, Bangkok 10700, Thailand. [Kalanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. [Endy, Timothy] SUNY Syracuse, Dept Infect Dis, Syracuse, NY USA. [Rothman, Alan L.] Univ Rhode Isl, Providence, RI 02908 USA. [Srikiatkhachorn, Anon] Univ Massachusetts, Sch Med, Dept Med, Worcester, MA USA. [Green, Sharone] Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, Worcester, MA USA. [Cummings, Derek A.; Salje, Henrik] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. RP Bhoomiboonchoo, P (reprint author), Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. EM augurivicky@gmail.com OI Salje, Henrik/0000-0003-3626-4254 FU National Institute of Allergy and Infectious Diseases [R01 AI102939-01A1]; National Science Foundation [BCS-1202983] FX The authors received no specific funding for this study except for HS, who was supported by the National Institute of Allergy and Infectious Diseases (grant number R01 AI102939-01A1) and the National Science Foundation (grant number BCS-1202983). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 24 TC 13 Z9 13 U1 0 U2 12 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD SEP PY 2014 VL 8 IS 9 AR e3138 DI 10.1371/journal.pntd.0003138 PG 6 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AQ4UZ UT WOS:000342796600028 PM 25211127 ER PT J AU Fortin, A Caridha, DP Leed, S Ngundam, F Sena, J Bosschaerts, T Parriott, S Hickman, MR Hudson, TH Grogl, M AF Fortin, Anny Caridha, Diana P. Leed, Susan Ngundam, Franklyn Sena, Jenell Bosschaerts, Tom Parriott, Sandi Hickman, Mark R. Hudson, Thomas H. Grogl, Max TI Direct Comparison of the Efficacy and Safety of Oral Treatments with Oleylphosphocholine (OlPC) and Miltefosine in a Mouse Model of L. major Cutaneous Leishmaniasis SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID VISCERAL LEISHMANIASIS; TOLERABILITY; FLUCONAZOLE; THERAPY AB Background: Cutaneous leishmaniasis (CL) represents a range of skin diseases caused by infection with Leishmania parasites and associated with tissue inflammation and skin ulceration. CL is clinically widespread in both the Old and New World but lacks treatments that are well tolerated, effective and inexpensive. Oleylphosphocholine (OlPC) is a new orally bioavailable drug of the alkylphosphocholine family with potent antileishmanial activity against a broad range of Leishmania species/strains. Methodology/principal findings: The potential of OlPC against Old World CL was evaluated in a mouse model of Leishmania (L.) major infection in BALB/c mice. Initial dose-response experiments showed that an oral daily dose of 40 mg/kg of OlPC was needed to impact time to cure and lesion sizes. This dose was then used to directly compare the efficacy of OlPC to the efficacy of the antileishmanial drugs miltefosine (40 mg/kg/day), fluconazole (160 mg/kg/day) and amphotericin B (25 mg/kg/day). OlPC, miltefosine and fluconazole were given orally for 21 days while amphotericin B was administered intraperitoneally for 10 days. Ulcer sizes and animal weights were followed up on a weekly basis and parasitemia was determined by means of a real-time in vivo imaging system which detects luminescence emitted from luciferase-expressing infecting L. major parasites. Amphotericin B and OlPC showed excellent efficacy against L. major lesions in terms of reduction of parasitic loads and by inducing complete healing of established lesions. In contrast, treatment with miltefosine did not significantly affect parasitemia and lesion sizes, while fluconazole was completely ineffective at the dose regimen tested. Conclusions/Significance: Given the data showing the outstanding efficacy and tolerability of OlPC, our results suggest that OlPC is a promising new drug candidate to improve and simplify current clinical management of L. major CL. C1 [Fortin, Anny] McGill Univ, Dept Biochem, Montreal, PQ, Canada. [Fortin, Anny; Bosschaerts, Tom] Dafra Pharma Res & Dev, Turnhout, Belgium. [Caridha, Diana P.; Leed, Susan; Ngundam, Franklyn; Sena, Jenell; Parriott, Sandi; Hickman, Mark R.; Hudson, Thomas H.; Grogl, Max] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. RP Fortin, A (reprint author), McGill Univ, Dept Biochem, Montreal, PQ, Canada. EM anny.fortin@dafra.be FU Military Infectious Diseases research Program (MIDRP), U.S. Army Medical Research and Materiel Command (USAMRMC) FX This research was funded by the Military Infectious Diseases research Program (MIDRP), U.S. Army Medical Research and Materiel Command (USAMRMC). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The opinions or assertions contained herein are the private views of the authors, and are not to be construed as official, or as reflecting the views of the Department of the Army or the Department of Defense. NR 18 TC 4 Z9 4 U1 2 U2 8 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD SEP PY 2014 VL 8 IS 9 AR e3144 DI 10.1371/journal.pntd.0003144 PG 7 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AQ4UZ UT WOS:000342796600033 PM 25210745 ER PT J AU Golnar, AJ Turell, MJ LaBeaud, AD Kading, RC Hamer, GL AF Golnar, Andrew J. Turell, Michael J. LaBeaud, A. Desiree Kading, Rebekah C. Hamer, Gabriel L. TI Predicting the Mosquito Species and Vertebrate Species Involved in the Theoretical Transmission of Rift Valley Fever Virus in the United States SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID WEST-NILE-VIRUS; NORTH-AMERICAN MOSQUITOS; DIPTERA-CULICIDAE; VECTOR COMPETENCE; BUNYAVIRIDAE PHLEBOVIRUS; EXPERIMENTAL-INFECTION; PUBLIC-HEALTH; PATHOGENESIS; DISEASE; BIRDS AB Rift Valley fever virus (RVFV) is a mosquito-borne virus in the family Bunyaviridiae that has spread throughout continental Africa to Madagascar and the Arabian Peninsula. The establishment of RVFV in North America would have serious consequences for human and animal health in addition to a significant economic impact on the livestock industry. Published and unpublished data on RVFV vector competence, vertebrate host competence, and mosquito feeding patterns from the United States were combined to quantitatively implicate mosquito vectors and vertebrate hosts that may be important to RVFV transmission in the United States. A viremia-vector competence relationship based on published mosquito transmission studies was used to calculate a vertebrate host competence index which was then combined with mosquito blood feeding patterns to approximate the vector and vertebrate amplification fraction, defined as the relative contribution of the mosquito or vertebrate host to pathogen transmission. Results implicate several Aedes spp. mosquitoes and vertebrates in the order Artiodactyla as important hosts for RVFV transmission in the U. S. Moreover, this study identifies critical gaps in knowledge which would be necessary to complete a comprehensive analysis identifying the different contributions of mosquitoes and vertebrates to potential RVFV transmission in the U. S. Future research should focus on (1) the dose-dependent relationship between viremic exposure and the subsequent infectiousness of key mosquito species, (2) evaluation of vertebrate host competence for RVFV among North American mammal species, with particular emphasis on the order Artiodactyla, and (3) identification of areas with a high risk for RVFV introduction so data on local vector and host populations can help generate geographically appropriate amplification fraction estimates. C1 [Golnar, Andrew J.; Hamer, Gabriel L.] Texas A&M Univ, Dept Entomol, College Stn, TX 77843 USA. [Turell, Michael J.] US Army Med Res Inst Infect Dis, Div Virol, Frederick, MD USA. [LaBeaud, A. Desiree] Childrens Hosp Oakland, Res Inst, Ctr Immunobiol & Vaccine Dev, Oakland, CA 94609 USA. [Kading, Rebekah C.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Arbovirus Dis Branch, Ft Collins, CO USA. RP Golnar, AJ (reprint author), Texas A&M Univ, Dept Entomol, College Stn, TX 77843 USA. EM ghamer@tamu.edu RI Kading, Rebekah/E-5633-2017; OI Kading, Rebekah/0000-0002-4996-915X; Golnar, Andrew/0000-0003-0747-5271 FU National Science Foundation/National Institutes of Health Ecology of Infectious Disease program [EF-0840403]; National Science Foundation [1252521] FX This project was funded through the National Science Foundation/National Institutes of Health Ecology of Infectious Disease program, #EF-0840403 and the National Science Foundation Graduate Research Fellowship program under Grant #1252521. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 80 TC 5 Z9 6 U1 2 U2 11 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD SEP PY 2014 VL 8 IS 9 AR e3163 DI 10.1371/journal.pntd.0003163 PG 11 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AQ4UZ UT WOS:000342796600044 PM 25211133 ER PT J AU Dykes, J Costello, M Fresconi, F Cooper, G AF Dykes, John Costello, Mark Fresconi, Frank Cooper, Gene TI Periodic projectile linear theory for aerodynamically asymmetric projectiles SO PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART G-JOURNAL OF AEROSPACE ENGINEERING LA English DT Article DE Asymmetric projectiles; Floquet theory; stability; flight dynamics ID DUAL-SPIN PROJECTILE; ATMOSPHERIC FLIGHT; INSTABILITY; GUIDANCE; MOTION; ROLL AB A new analytical tool is proposed to aid in the design and performance evaluation of advanced guided projectile concepts. A projectile linear theory applicable to aerodynamically asymmetric configurations is created, leading to a linear, periodic dynamic system. Utilizing concepts in Floquet theory, stability of asymmetric projectile configurations is explored. While stability of many asymmetric projectile configurations can be accurately predicted using averaged linear, constant coefficient system dynamics, there are some configurations where the use of linear periodic systems theory is required for accurate stability prediction. This fact is shown by comparing stability boundaries of an example projectile configuration using the conventional projectile linear theory model and the new periodic projectile linear theory model. C1 [Dykes, John] Georgia Inst Technol, Sch Aerosp Engn, Atlanta, GA 30332 USA. [Costello, Mark] Georgia Inst Technol, Sch Aerosp Engn, Sch Mech Engn, Atlanta, GA 30332 USA. [Fresconi, Frank; Cooper, Gene] US Army Res Labs, Weap & Mat Res Directorate, Aberdeen, MD USA. RP Costello, M (reprint author), Georgia Inst Technol, Atlanta, GA 30332 USA. EM mark.costello@ae.gatech.edu OI William, John/0000-0001-7617-9148 FU Weapons and Materials Research Directorate of the U.S. Army Research Laboratory FX This research was supported by the Weapons and Materials Research Directorate of the U.S. Army Research Laboratory. NR 37 TC 0 Z9 0 U1 4 U2 10 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0954-4100 EI 2041-3025 J9 P I MECH ENG G-J AER JI Proc. Inst. Mech. Eng. Part G-J. Aerosp. Eng. PD SEP PY 2014 VL 228 IS 11 BP 2094 EP 2107 DI 10.1177/0954410013514346 PG 14 WC Engineering, Aerospace; Engineering, Mechanical SC Engineering GA AQ4VR UT WOS:000342798900014 ER PT J AU Klapotke, TM Rusan, M Sabatini, JJ AF Klapoetke, Thomas M. Rusan, Magdalena Sabatini, Jesse J. TI Chlorine-Free Pyrotechnics: Copper(I) Iodide as a "Green" Blue-Light Emitter SO ANGEWANDTE CHEMIE-INTERNATIONAL EDITION LA English DT Article DE blue flame colors; color performance; copper; pyrotechnics; sensitivities AB The generation of blue-light-emitting pyrotechnic formulations without the use of chlorine-containing compounds is reported. Suitable blue-light emission has been achieved through the generation of molecular emitting copper(I) iodide. The most optimal copper(I) iodide based blue-light-emitting formulation was found to have performances exceeding those of chlorine-containing compositions, and was found to be insensitive to various ignition stimuli. C1 [Klapoetke, Thomas M.; Rusan, Magdalena] Univ Munich, Dept Chem, D-81377 Munich, Germany. [Sabatini, Jesse J.] US Army RDECOM ARDEC, Pyrotech Technol & Prototyping Div, Picatinny Arsenal, NJ 08706 USA. RP Klapotke, TM (reprint author), Univ Munich, Dept Chem, Butenandtstr 5-13,Haus D, D-81377 Munich, Germany. EM tmk@cup.uni-muenchen.de; jesse.j.sabatini.civ@mail.mil RI Klapoetke, Thomas/B-6055-2014 OI Klapoetke, Thomas/0000-0003-3276-1157 FU LMU; ARL; ONR; ARDEC FX Financial support of this work by LMU, ARL, ONR, and ARDEC is gratefully acknowledged. NR 19 TC 4 Z9 4 U1 2 U2 25 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 1433-7851 EI 1521-3773 J9 ANGEW CHEM INT EDIT JI Angew. Chem.-Int. Edit. PD SEP 1 PY 2014 VL 53 IS 36 BP 9665 EP 9668 DI 10.1002/anie.201405195 PG 4 WC Chemistry, Multidisciplinary SC Chemistry GA AQ3FZ UT WOS:000342677000047 PM 25044436 ER PT J AU Grodowitz, MJ Johnson, S Schad, AN AF Grodowitz, Michael J. Johnson, Seth Schad, Aaron N. TI EFFICIENCY OF SAMPLING TO DETERMINE POPULATION SIZE OF CYRTOBAGOUS SALVINIAE (COLEOPTERA: CURCULIONIDAE) SO FLORIDA ENTOMOLOGIST LA English DT Article DE biological control; giant salvinia; sampling; mass-rearing ID NEGATIVE BINOMIAL-DISTRIBUTION; MOLESTA AB Salvinia molesta D. S. Mitchell (Salviniales: Salviniaceae), a small floating fern introduced from South America, is causing an increasing number of problems in the US. Increased reliance on the biocontrol agent, Cyrtobagous salviniae, in the US is becoming more commonplace and several mass-rearing facilities have been developed. Because of differences in sampling protocols including sample size, reporting parameters, and numbers released, an investigation into sampling efficiency was initiated. A small pond in southern Louisiana was sampled in an effort to understand what constitutes an adequate sample size and methodologies needed to estimate numbers of weevils. A clumped distribution in the pond was identified, which required a large number of samples to be taken to minimize differences in means and variation. When randomly selecting 10 sets of samples where n = 5 for Sep, means varied from a high of 280 weevils/m(2) to a low of only 50 weevils/m(2), a difference of nearly 6-fold. However, when randomly selecting 10 sets of samples where n = 20, means were much more consistent and varied from a high of approximately 250 weevils/m(2) to a low of 125 weevils/m(2), a difference of only 2-fold. Sampling is expensive and to gain the most information based on the number of samples taken it is recommended that 1) the confidence interval be reported, especially when releasing weevils based on an estimation of population size; 2) understand spatial distribution and sample accordingly; and 3) when possible, initiate pilot sampling programs to acquire prior information on sampling biases, sampling errors, and differences in distribution. C1 [Grodowitz, Michael J.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Johnson, Seth] Louisiana State Univ, Dept Entomol, AgCtr, Baton Rouge, LA 70803 USA. [Schad, Aaron N.] US Army Engineer Res & Dev Ctr, Lewisville Aquat Ecosyst Res Facil, Lewisville, TX 75057 USA. RP Johnson, S (reprint author), Louisiana State Univ, Dept Entomol, AgCtr, 404 Life Sci Bldg, Baton Rouge, LA 70803 USA. EM SJohnson@agcenter.lsu.edu FU US Army Aquatic Plant Control Research Program FX This research was supported by the US Army Aquatic Plant Control Research Program, under the management of Dr. Linda Nelson. Permission was granted by the Chief of Engineers to publish this information. We also thank Nathan Harms and Katherine Parys for their review of this manuscript. We also like to thank Lee Eisenberg and Julie Nachtrieb for their technical assistance. Special thanks goes out to Nathan Harms for his patience in our long and numerous discussions on sampling efficiency. NR 27 TC 0 Z9 0 U1 1 U2 12 PU FLORIDA ENTOMOLOGICAL SOC PI LUTZ PA 16125 E LAKE BURRELL DR, LUTZ, FL 33548 USA SN 0015-4040 EI 1938-5102 J9 FLA ENTOMOL JI Fla. Entomol. PD SEP PY 2014 VL 97 IS 3 BP 1213 EP 1225 PG 13 WC Entomology SC Entomology GA AQ1JM UT WOS:000342537700043 ER PT J AU Esposito, ER Wilken, JM AF Esposito, Elizabeth Russell Wilken, Jason M. TI The relationship between pelvis-trunk coordination and low back pain in individuals with transfemoral amputations SO GAIT & POSTURE LA English DT Article DE Amputee; Military; Continuous relative phase; Walking; Variability ID DYNAMICAL-SYSTEMS APPROACH; LUMBAR SPINE; WALKING; LIMB; GAIT; VARIABILITY; KINEMATICS; LOCOMOTION; DISORDERS; AMPUTEES AB Low back pain (LBP) is common in individuals with transfemoral amputation and may result from altered gait mechanics associated with prosthetic use. Inter-segmental coordination, assessed through continuous relative phase (CRP), has been used to identify specific patterns as risk factors. The purpose of this study was to explore pelvis and trunk inter-segmental coordination across three walking speeds in individuals with transfemoral amputations with and without LBP. Nine individuals with transfemoral amputations with LBP and seven without pain were compared to twelve able-bodied subjects. Subjects underwent a gait analysis while walking at slow, moderate, and fast speeds. CRP and CRP variability were calculated from three-dimensional pelvis and trunk segment angles. A two-way ANOVA and post hoc tests assessed statistical significance. Individuals with transfemoral amputation demonstrated some coordination patterns that were different from able-bodied individuals, but consistent with previous reports on persons with LBP. The patient groups maintained transverse plane CRP consistent with able-bodied participants (p = 0.966), but not sagittal (p < 0.001) and frontal plane CRP (p = 0.001). Sagittal and frontal CRP may have been re-optimized based on new sets of constraints, such as protective rigidity of the segments, muscular strength limitations, or prosthesis limitations. Patients with amputations and without LBP exhibited few differences. Only frontal and transverse CRP shifted toward out-of-phase as speed increased in the patient group with LBP. Although a cause and effect relationship between CRP and future development of back pain has yet to be determined, these results add to the literature characterizing biomechanical parameters of back pain in high-risk populations. Published by Elsevier B.V. C1 [Esposito, Elizabeth Russell; Wilken, Jason M.] Brooke Army Med Ctr, Ctr Intrepid, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. RP Esposito, ER (reprint author), Brooke Army Med Ctr, Ctr Intrepid, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. EM erussell.kin@gmail.com OI Russell Esposito, Elizabeth/0000-0001-5321-0333; Wilken, Jason/0000-0002-5556-7667 FU Telemedicine and Advanced Technology Research Center; Center for Rehabilitation Sciences Research, Uniformed Services University of the Health Sciences, Bethesda, MD FX This study was supported by the Telemedicine and Advanced Technology Research Center and the Center for Rehabilitation Sciences Research, Uniformed Services University of the Health Sciences, Bethesda, MD. NR 30 TC 4 Z9 4 U1 2 U2 9 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0966-6362 EI 1879-2219 J9 GAIT POSTURE JI Gait Posture PD SEP PY 2014 VL 40 IS 4 BP 640 EP 646 DI 10.1016/j.gaitpost.2014.07.019 PG 7 WC Neurosciences; Orthopedics; Sport Sciences SC Neurosciences & Neurology; Orthopedics; Sport Sciences GA AQ0WA UT WOS:000342502200029 ER PT J AU Prager, EM Pidoplichko, VI Aroniadou-Anderjaska, V Apland, JP Braga, MFM AF Prager, Eric M. Pidoplichko, Volodymyr I. Aroniadou-Anderjaska, Vassiliki Apland, James P. Braga, Maria F. M. TI Pathophysiological mechanisms underlying increased anxiety after soman exposure: Reduced GABAergic inhibition in the basolateral amygdala SO NEUROTOXICOLOGY LA English DT Article DE Soman; Basolateral amygdala; Anxiety; GABA Inhibition; Alpha7 nicotinic receptors ID POSTTRAUMATIC-STRESS-DISORDER; NICOTINIC ACETYLCHOLINE-RECEPTORS; LONG-TERM CONSEQUENCES; AGENT-INDUCED SEIZURE; STATUS EPILEPTICUS; GABA(A) RECEPTORS; CHOLINE-ACETYLTRANSFERASE; ANIMAL-MODELS; FOLLOW-UP; RAT AB The recent sarin attack in Syria killed 1429 people, including 426 children, and left countless more to deal with the health consequences of the exposure. Prior to the Syrian chemical assault, nerve agent attacks in Japan left many victims suffering from neuropsychiatric illnesses, particularly anxiety disorders, more than a decade later. Uncovering the neuro-pathophysiological mechanisms underlying the development of anxiety after nerve agent exposure is necessary for successful treatment. Anxiety is associated with hyperexcitability of the basolateral amygdala (BLA). The present study sought to determine the nature of the nerve agent-induced alterations in the BLA, which could explain the development of anxiety. Rats were exposed to soman, at a dose that induced prolonged status epilepticus. Twenty-four hours and 14-days after exposure, neurons from the BLA were recorded using whole-cell patch-clamp techniques. At both the 24 h and 14-day post-exposure time-points, the frequency and amplitude of spontaneous inhibitory postsynaptic currents (sIPSCs) in the BLA were reduced, along with reduction in the frequency but not amplitude of miniature IPSCs. In addition, activation of alpha(7)-nicotinic acetylcholine receptors, a cholinergic receptor that participates in the regulation of BLA excitability and is involved in anxiety, increased spontaneous excitatory postsynaptic currents (sEPSCs) in both soman-exposed rats and controls, but was less effective in increasing sIPSCs in soman-exposed rats. Despite the loss of both interneurons and principal cells after soman-induced status epilepticus, the frequency of sEPSCs was increased in the soman-exposed rats. Impaired function and cholinergic modulation of GABAergic inhibition in the BLA may underlie anxiety disorders that develop after nerve agent exposure. Published by Elsevier Inc. C1 [Prager, Eric M.; Pidoplichko, Volodymyr I.; Aroniadou-Anderjaska, Vassiliki; Braga, Maria F. M.] Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. [Aroniadou-Anderjaska, Vassiliki; Braga, Maria F. M.] Uniformed Serv Univ Hlth Sci, Dept Psychiat, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. [Prager, Eric M.; Aroniadou-Anderjaska, Vassiliki; Braga, Maria F. M.] Uniformed Serv Univ Hlth Sci, Program Neurosci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. [Apland, James P.] US Army Med Res Inst Chem Def, Neurotoxicol Branch, Aberdeen Proving Ground, MD 21010 USA. RP Braga, MFM (reprint author), Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, F Edward Hebert Sch Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM eric.prager683@gmail.com; volodymyr.pidoplichko.ctr@usuhs.edu; vassiliki.aroniadou-anderjaska.ctr@usuhs.edu; James.p.apland.civ@mail.mil; maria.braga@usuhs.edu RI Prager, Eric/O-1567-2015 OI Prager, Eric/0000-0002-3810-0985 FU CounterACT program, National Institutes of Health, Office of the Director; National Institute of Neurologic Disorders and Stroke [5U01NS058162-07] FX This work was supported by the CounterACT program, National Institutes of Health, Office of the Director and the National Institute of Neurologic Disorders and Stroke [Grant Number 5U01NS058162-07]. We thank Dr. Cara Olsen for assistance on statistical analyses. NR 68 TC 8 Z9 8 U1 0 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0161-813X EI 1872-9711 J9 NEUROTOXICOLOGY JI Neurotoxicology PD SEP PY 2014 VL 44 BP 335 EP 343 DI 10.1016/j.neuro.2014.08.007 PG 9 WC Neurosciences; Pharmacology & Pharmacy; Toxicology SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology GA AQ2XY UT WOS:000342654500035 PM 25150775 ER PT J AU Coleman, LS Ford, WM Dobony, CA Britzke, ER AF Coleman, Laci S. Ford, W. Mark Dobony, Christopher A. Britzke, Eric R. TI Comparison of Radio-telemetric Home-Range Analysis and Acoustic Detection for Little Brown Bat Habitat Evaluation SO NORTHEASTERN NATURALIST LA English DT Article ID WHITE-NOSE SYNDROME; MYOTIS-LUCIFUGUS; SOUTH-CAROLINA; COASTAL-PLAIN; INDIANA BAT; OCCUPANCY; LANDSCAPE; PATTERNS; SCALES; SIZE AB With dramatic declines of bat populations due to mortality caused by Pseudogymnoascus destruclans (White-nose Syndrome), assessing habitat preferences of bats in the northeastern US is now critical to guide the development of regional conservation efforts. In the summer of 2012, we conducted fixed-station simultaneous telemetry to determine nocturnal spatial use and fixed-kernel home-range estimates of available habitat of a Myotis lucifugus (Le Conte) (Little Brown Bat) maternity colony in an artificial bat house. In summers of 2011 and 2012, we also deployed a 52-ha grid of 4 x 4 Anabat acoustic detectors over five 6-8-day sampling periods in various riparian and non-riparian environments in close proximity to the same bat house. The mean telemetry home range of 143 ha for bats (n = 7) completely overlapped the acoustic grid. Rankings of habitats from telemetry data for these 7 bats and 5 additional bats not included in home-range calculations but added for habitat-use measures (n = 13) revealed a higher proportional use of forested riparian habitats than other types at the landscape scale. Pair-wise comparisons of habitats indicated that bats were found significantly closer to forested riparian habitats and forests than to open water, developed areas, fields. shrublands, or wetland habitats at the landscape scale. Acoustic sampling showed that naive occupancy was 0.8 and 0.6 and mean nightly detection probabilities were 0.23 and 0.08 at riparian and non-riparian sites, respectively. Our findings suggest that Little Brown Bats select forested riparian and forested habitats for foraging at the landscape scale but may be most easily detected acoustically at riparian sites when a simple occupancy determination for an area is required. C1 [Coleman, Laci S.] Virginia Tech, Dept Fisheries & Wildlife Conservat, Blacksburg, VA 24061 USA. [Ford, W. Mark] US Geol Survey, Virginia Cooperat Fish & Wildlife Res Unit, Blacksburg, VA 24061 USA. [Dobony, Christopher A.] Ft Drum Mil Installat, IMNE DRM PWE, Nat Resources Branch, Ft Drum, NY 13602 USA. [Britzke, Eric R.] US Army Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Ford, WM (reprint author), US Geol Survey, Virginia Cooperat Fish & Wildlife Res Unit, 106 Cheatham Hall, Blacksburg, VA 24061 USA. EM wmford@vt.edu FU Fort Drum Natural Resources Branch through National Park Service, Southern Appalachian Cooperative Ecosystem Study Unit [W9126G-11-2-SOI-0029]; US Geological Survey Cooperative Research Unit Research Work Order [VA-RWO-142] FX Funding for this study was provided by the Fort Drum Natural Resources Branch through National Park Service, Southern Appalachian Cooperative Ecosystem Study Unit contract W9126G-11-2-SOI-0029 and the US Geological Survey Cooperative Research Unit Research Work Order VA-RWO-142. We thank R. Rainbolt, A. Dale, S. Dedrick, G. Luongo, and N. Grosse for field assistance. An earlier draft of this manuscript was reviewed by D. Stauffer. NR 46 TC 0 Z9 0 U1 9 U2 52 PU HUMBOLDT FIELD RESEARCH INST PI STEUBEN PA PO BOX 9, STEUBEN, ME 04680-0009 USA SN 1092-6194 EI 1938-5307 J9 NORTHEAST NAT JI Northeast. Nat PD SEP PY 2014 VL 21 IS 3 BP 431 EP 445 DI 10.1656/045.021.0309 PG 15 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA AQ0QS UT WOS:000342488400012 ER PT J AU Muldoon, SF Bassett, DS AF Muldoon, Sarah Feldt Bassett, Danielle S. TI Why network neuroscience? Compelling evidence and current frontiers Comment on "Understanding brain networks and brain organization" by Luiz Pessoa SO PHYSICS OF LIFE REVIEWS LA English DT Editorial Material DE Brain networks; Neuroscience; Dynamics; Functional connectivity; Graph theory ID FUNCTIONAL CONNECTIVITY; COMPLEXITY; CORTEX C1 [Muldoon, Sarah Feldt; Bassett, Danielle S.] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA. [Muldoon, Sarah Feldt] US Army Res Lab, Aberdeen Proving Ground, MD 21001 USA. [Bassett, Danielle S.] Univ Penn, Dept Elect & Syst Engn, Philadelphia, PA 19104 USA. RP Bassett, DS (reprint author), Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA. OI Muldoon, Sarah/0000-0002-2830-9291 NR 29 TC 3 Z9 3 U1 1 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1571-0645 EI 1873-1457 J9 PHYS LIFE REV JI Phys. Life Rev. PD SEP PY 2014 VL 11 IS 3 BP 455 EP 457 DI 10.1016/j.plrev.2014.06.006 PG 3 WC Biology; Biophysics SC Life Sciences & Biomedicine - Other Topics; Biophysics GA AQ1KW UT WOS:000342541300022 PM 24954730 ER PT J AU Crawford, KW AF Crawford, Keith W. TI Etravirine and rilpivirine-specific mutations selected by efavirenz and nevirapine exposure in patients infected with HIV-1 non-B subtypes SO AIDS LA English DT Letter C1 [Crawford, Keith W.] Walter Reed Army Inst Res, US Mil HIV Res Program, Global Hlth Programs, Silver Spring, MD USA. [Crawford, Keith W.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. RP Crawford, KW (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Bethesda, MD 20910 USA. EM kwcrawford1@gmail.com NR 1 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0269-9370 EI 1473-5571 J9 AIDS JI Aids PD SEP PY 2014 VL 28 IS 15 BP 2331 EP 2332 DI 10.1097/QAD.0000000000000350 PG 2 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AP7BF UT WOS:000342231900020 PM 25050862 ER PT J AU Mittendorf, EA Clifton, GT Holmes, JP Schneble, E van Echo, D Ponniah, S Peoples, GE AF Mittendorf, E. A. Clifton, G. T. Holmes, J. P. Schneble, E. van Echo, D. Ponniah, S. Peoples, G. E. TI Final report of the phase I/II clinical trial of the E75 (nelipepimut-S) vaccine with booster inoculations to prevent disease recurrence in high-risk breast cancer patients SO ANNALS OF ONCOLOGY LA English DT Article DE breast cancer; nelipepimut-S; vaccine; immunotherapy ID GROUP-STUDY I-01; PEPTIDE VACCINE; HER-2/NEU; IMMUNIZATION; INTERLEUKIN-2; IMMUNOTHERAPY; VACCINATIONS; IMMUNITY; MELANOMA; P369-377 AB Background: E75 (nelipepimut-S) is a human leukocyte antigen (HLA)-A2/A3-restricted immunogenic peptide derived from the HER2 protein. We have conducted phase I/II clinical trials vaccinating breast cancer patients with nelipepimut-S and granulocyte-macrophage colony-stimulating factor (GM-CSF) in the adjuvant setting to prevent disease recurrence. All patients have completed 60 months follow-up, and here, we report the final analyses. Patients and methods: The studies were conducted as dose escalation/schedule optimization trials enrolling node-positive and high-risk node-negative patients with tumors expressing any degree of HER2 (immunohistochemistry 1-3+). HLA-A2/3+ patients were vaccinated; others were followed prospectively as controls. Local and systemic toxicity was monitored. Clinical recurrences were documented, and disease-free survival (DFS) was analyzed by Kaplan-Meier curves; groups were compared using log-rank tests. Results: Of 195 enrolled patients, 187 were assessable: 108 (57.8%) in the vaccinated group (VG) and 79 (42.2%) in the control group (CG). The groups were well matched for clinicopathologic characteristics. Toxicities were minimal. Five-year DFS was 89.7% in the VG versus 80.2% in the CG (P = 0.08). Due to trial design, 65% of patients received less than the optimal vaccine dose. Five-year DFS was 94.6% in optimally dosed patients (P = 0.05 versus the CG) and 87.1% in suboptimally dosed patients. A voluntary booster program was initiated, and among the 21 patients that were optimally boosted, there was only one recurrence (DFS = 95.2%). Conclusion: The E75 vaccine is safe and appears to have clinical efficacy. A phase III trial evaluating the optimal dose and including booster inoculations has been initiated. C1 [Mittendorf, E. A.] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA. [Clifton, G. T.] Blanchfield Army Community Hosp, Ft Campbell, KY USA. [Holmes, J. P.] Redwood Reg Med Grp, Santa Rosa, CA USA. [Schneble, E.; Peoples, G. E.] Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. [van Echo, D.] Walter Reed Army Med Ctr, Dept Hematol Oncol, Washington, DC 20307 USA. [Ponniah, S.; Peoples, G. E.] Uniformed Serv Univ Hlth Sci, US Mil Canc Inst, Canc Vaccine Dev Program, Dept Surg, Bethesda, MD 20814 USA. RP Peoples, GE (reprint author), Brooke Army Med Ctr, Dept Surg, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM george.peoples@us.army.mil FU United States Military Cancer Institute, Department of Surgery, Uniformed Services University of the Health Sciences; Clinical Breast Care Project; Department of Clinical Investigation, Walter Reed Army Medical Center; Jeanne F. Shelby Scholarship Fund FX This work was funded by the United States Military Cancer Institute, Department of Surgery, Uniformed Services University of the Health Sciences; Clinical Breast Care Project; and the Department of Clinical Investigation, Walter Reed Army Medical Center. No NIH grant funding supported this work. Funding sources were not involved with the study design; in the collection, analysis, or interpretation of data; in the writing of the report; or in the decision to submit the paper for publication. E. A. M. is an R. Lee Clark Fellow at the University of Texas MD Anderson Cancer Center supported by the Jeanne F. Shelby Scholarship Fund. NR 18 TC 43 Z9 45 U1 0 U2 7 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0923-7534 EI 1569-8041 J9 ANN ONCOL JI Ann. Oncol. PD SEP PY 2014 VL 25 IS 9 BP 1735 EP 1742 DI 10.1093/annonc/mdu211 PG 9 WC Oncology SC Oncology GA AP8UB UT WOS:000342353600009 PM 24907636 ER PT J AU Yankowitz, M Wang, JIJ Li, SC Birdwell, AG Chen, YA Watanabe, K Taniguchi, T Quek, SY Jarillo-Herrero, P LeRoy, BJ AF Yankowitz, Matthew Wang, Joel I-Jan Li, Suchun Birdwell, A. Glen Chen, Yu-An Watanabe, Kenji Taniguchi, Takashi Quek, Su Ying Jarillo-Herrero, Pablo LeRoy, Brian J. TI Band structure mapping of bilayer graphene via quasiparticle scattering SO APL MATERIALS LA English DT Article ID BORON-NITRIDE; INTERFERENCE; SURFACE AB A perpendicular electric field breaks the layer symmetry of Bernal-stacked bilayer graphene, resulting in the opening of a band gap and a modification of the effective mass of the charge carriers. Using scanning tunneling microscopy and spectroscopy, we examine standing waves in the local density of states of bilayer graphene formed by scattering from a bilayer/trilayer boundary. The quasiparticle interference properties are controlled by the bilayer graphene band structure, allowing a direct local probe of the evolution of the band structure of bilayer graphene as a function of electric field. We extract the Slonczewski-Weiss-McClure model tight binding parameters as gamma(0) = 3.1 eV, gamma(1) = 0.39 eV, and y4 = 0.22 eV. (C) 2014 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 Unported License. C1 [Yankowitz, Matthew; LeRoy, Brian J.] Univ Arizona, Dept Phys, Tucson, AZ 85721 USA. [Wang, Joel I-Jan; Chen, Yu-An; Jarillo-Herrero, Pablo] MIT, Dept Phys, Cambridge, MA 02138 USA. [Wang, Joel I-Jan] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA. [Li, Suchun; Quek, Su Ying] Natl Univ Singapore, Dept Phys, Fac Sci, Singapore 117551, Singapore. [Li, Suchun; Quek, Su Ying] Agcy Sci Technol & Res, Inst High Performance Comp, Singapore 138632, Singapore. [Li, Suchun] Natl Univ Singapore, NUS Grad Sch Integrat Sci & Engn, Singapore 117456, Singapore. [Birdwell, A. Glen] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Watanabe, Kenji; Taniguchi, Takashi] Natl Inst Mat Sci, Tsukuba, Ibaraki 3050044, Japan. RP Yankowitz, M (reprint author), Univ Arizona, Dept Phys, 1118 E 4th St, Tucson, AZ 85721 USA. EM leroy@physics.arizona.edu RI Quek, Su Ying/I-2934-2014; TANIGUCHI, Takashi/H-2718-2011; WATANABE, Kenji/H-2825-2011 OI WATANABE, Kenji/0000-0003-3701-8119 FU U.S. Army Research Laboratory; U.S. Army Research Office [W911NF-09-1-0333]; National Science Foundation [DMR-0953784]; Taiwan Merit Scholarship [TMS-094-1-A-001]; US DOE, BES Office, Division of Materials Sciences and Engineering [DE-SC0001819]; NSF [DMR-0845287, DMR-0819762, ECS-0335765]; ONR GAIL MURI; U.S. Army Research Laboratory (ARL) Director's Strategic Initiative; A*STAR Graduate Scholarship; IHPC; Singapore NRF Fellowship [NRF-NRFF2013-07] FX M.Y. and B.J.L. were supported by the U.S. Army Research Laboratory and the U.S. Army Research Office under Contract/Grant No. W911NF-09-1-0333 and the National Science Foundation CAREER award DMR-0953784. J.I-J.W. was partially supported by a Taiwan Merit Scholarship TMS-094-1-A-001. J.I.-J.W and P.J.-H. have been primarily supported by the US DOE, BES Office, Division of Materials Sciences and Engineering under Award DE-SC0001819. Early fabrication feasibility studies were supported by NSF Career Award No. DMR-0845287 and the ONR GAIL MURI. This work made use of the MRSEC Shared Experimental Facilities supported by NSF under Award No. DMR-0819762 and of Harvard's CNS, supported by NSF under Grant No. ECS-0335765. A.G.B. was supported by the U.S. Army Research Laboratory (ARL) Director's Strategic Initiative program on interfaces in stacked 2D atomic layered materials. S.L. is supported by the A*STAR Graduate Scholarship. S.Y.Q. is supported by the IHPC Independent Investigatorship and Singapore NRF Fellowship (NRF-NRFF2013-07). We thank NUS Graphene Research Centre, A*CRC, and Professor Feng Yuan Ping's Lab in NUS for computational support. NR 27 TC 2 Z9 2 U1 4 U2 29 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 2166-532X J9 APL MATER JI APL Mater. PD SEP PY 2014 VL 2 IS 9 AR 092503 DI 10.1063/1.4890543 PG 7 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Science & Technology - Other Topics; Materials Science; Physics GA AQ1UO UT WOS:000342568000006 ER PT J AU Ana-Sosa-Batiz, F Johnston, APR Liu, HY Center, RJ Rerks-Ngarm, S Pitisuttithum, P Nitayaphan, S Kaewkungwal, J Kim, JH Michael, NL Kelleher, AD Stratov, I Kent, SJ Kramski, M AF Ana-Sosa-Batiz, Fernanda Johnston, Angus P. R. Liu, Haiyin Center, Robert J. Rerks-Ngarm, Supachai Pitisuttithum, Punnee Nitayaphan, Sorachai Kaewkungwal, Jaranit Kim, Jerome H. Michael, Nelson L. Kelleher, Anthony D. Stratov, Ivan Kent, Stephen J. Kramski, Marit TI HIV-specific antibody-dependent phagocytosis matures during HIV infection SO IMMUNOLOGY AND CELL BIOLOGY LA English DT Article ID SIMIAN/HUMAN IMMUNODEFICIENCY VIRUS; VACCINE EFFICACY TRIAL; FC-RECEPTOR; CYTOTOXICITY RESPONSES; NEUTRALIZING ANTIBODY; DISEASE PROGRESSION; EFFECTOR FUNCTION; MACAQUES; CELLS; PROTECTION AB Antibody-dependent phagocytosis (ADP) is a potentially important immune mechanism to clear HIV. How HIV-specific ADP responses mature during HIV infection or in response to vaccinations administered, including the partially successful RV144 HIV vaccine, is not known. We established a modified ADP assay to measure internalisation of HIV antibody (Ab)-opsonised targets using a specific hybridisation internalisation probe. Labelled beads were coated with both biotinylated HIV gp140 envelope protein and a fluorescent internalisation probe, opsonised with Abs and incubated with a monocytic cell line. The fluorescence derived from the fluorescent internalisation probe on surface-bound beads, but not from internalised beads, was quenched by the addition of a complementary quencher probe. HIV Env-specific ADP was measured in 31 subjects during primary infection and early chronic HIV infection. Although ADP responses were present early during HIV infection, a significant increase in ADP responses in all 31 subjects studied was detected (P < 0.001). However, when we tested 30 HIV-negative human subjects immunised with the Canarypox/gp120 vaccine regimen (subjects from the RV144 trial) we did not detect HIV-specific ADP activity. In conclusion, a modified assay was developed to measure HIV-specific ADP. Enhanced ADP responses early in the course of HIV infection were observed but no ADP activity was detected following the vaccinations administered in the RV144 trial. Improved vaccine regimens may be needed to capitalise on ADP-mediated immunity against HIV. C1 [Ana-Sosa-Batiz, Fernanda; Kent, Stephen J.; Kramski, Marit] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Melbourne, Vic, Australia. [Johnston, Angus P. R.; Liu, Haiyin] Monash Univ, Monash Inst Pharmaceut Sci, Parkville, Vic, Australia. [Johnston, Angus P. R.] Monash Univ, ARC Ctr Excellence Convergent Bionano Sci & Techn, Parkville, Vic, Australia. [Center, Robert J.] Burnet Inst, Melbourne, Vic, Australia. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Bangkok, Thailand. [Pitisuttithum, Punnee] Mahidol Univ, Fac Trop Med, Bangkok, Thailand. [Nitayaphan, Sorachai] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Kaewkungwal, Jaranit] Mahidol Univ, Data Management Unit, Bangkok 10700, Thailand. [Kim, Jerome H.; Michael, Nelson L.] Walter Reed Army Inst Res, USA Mil HIV Res Program, Rockville, MD USA. [Kelleher, Anthony D.] UNSW Med, Kirby Inst Infect & Immun Soc, Sydney, NSW, Australia. [Kent, Stephen J.] Univ Melbourne, ARC Ctr Excellence Convergent Bionano Sci & Techn, Melbourne, Vic, Australia. RP Kent, SJ (reprint author), Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, 792 Elizabeth St, Parkville, Vic 3010, Australia. EM skent@unimelb.edu.au RI Johnston, Angus/A-9254-2011; OI Johnston, Angus/0000-0001-5611-4515; Liu, Haiyin/0000-0003-3103-6949; Kent, Stephen/0000-0002-8539-4891 FU NHMRC [510448] FX This work was supported by NHMRC program grant no. 510448. The views expressed in this manuscript are those of the authors and do not reflect the views of the US Army or the US Department of Defense. We thank the RV144 trial participants, the whole RV144 study team and all patients and blood donors. We thank Dr Wendy Winnall for statistical advice. NR 32 TC 9 Z9 9 U1 2 U2 11 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0818-9641 EI 1440-1711 J9 IMMUNOL CELL BIOL JI Immunol. Cell Biol. PD SEP PY 2014 VL 92 IS 8 BP 679 EP 687 DI 10.1038/icb.2014.42 PG 9 WC Cell Biology; Immunology SC Cell Biology; Immunology GA AP9CP UT WOS:000342376300079 PM 24913323 ER PT J AU Shin, S Truong, NKV Goethals, PL Cho, BR Jeong, SH AF Shin, Sangmun Nguyen Khoa Viet Truong Goethals, Paul L. Cho, Byung Rae Jeong, Seong Hoon TI Robust design modeling and optimization of a multi-response time series for a pharmaceutical process SO INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY LA English DT Article DE Pharmaceutical formulation; Quality by design; Robust design; Response surface methodology; Time series response ID RESPONSE-SURFACE OPTIMIZATION; RELEASE AB Robust design (RD) methods, which are based upon the concept of building quality into products or processes, are increasingly popular in the science and engineering research communities. One particular area of RD research that has not received considerable attention is in working with multiple time series responses, observed frequently within the field of pharmaceutical science. In order to determine the optimal pharmaceutical formulation, or input factor settings, suitable robust experimental design and analysis methods must be performed. To achieve this objective, the primary aim of this paper is to propose a new methodology that specifically addresses the multi-response time series problem for a pharmaceutical formulation process. First, an experimental format and framework for testing drug release kinetics is proposed by implementing a mixture experimental design and time series response modeling. Second, an alternative robust design model is developed to identify the optimal pharmaceutical formulation, based upon the time series target profiles for drug release kinetics. Finally, a case study associated with a drug development process is performed to validate the proposed model. The results of this case study indicate that the optimal drug release kinetics is significantly similar to the target profile. C1 [Shin, Sangmun] Dong A Univ, Pusan, South Korea. [Nguyen Khoa Viet Truong] Inje Univ, Gimhae, KN, South Korea. [Goethals, Paul L.] US Mil Acad, West Point, NY 10996 USA. [Cho, Byung Rae] Clemson Univ, Clemson, SC USA. [Jeong, Seong Hoon] Dongguk Univ Seoul, Gyeonggi, South Korea. RP Shin, S (reprint author), Dong A Univ, Pusan, South Korea. EM sshin@dau.ac.kr; nkvtruong@hcmuns.edu.vn; Paul.goethals@usma.edu; bcho@clemson.edu; shjeong@dongguk.edu FU Dong-A University research fund FX This work was supported by the Dong-A University research fund.. NR 26 TC 2 Z9 2 U1 1 U2 8 PU SPRINGER LONDON LTD PI LONDON PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND SN 0268-3768 EI 1433-3015 J9 INT J ADV MANUF TECH JI Int. J. Adv. Manuf. Technol. PD SEP PY 2014 VL 74 IS 5-8 BP 1017 EP 1031 DI 10.1007/s00170-014-6036-8 PG 15 WC Automation & Control Systems; Engineering, Manufacturing SC Automation & Control Systems; Engineering GA AQ0PX UT WOS:000342486300040 ER PT J AU Liao, JJ Jewell, P Parvathaneni, U Laramore, G Polissar, N Wong, W AF Liao, J. J. Jewell, P. Parvathaneni, U. Laramore, G. Polissar, N. Wong, W. TI Management and Long-Term Outcomes of Sinonasal Undifferentiated Carcinoma: Twenty-Year Experience at a Single Institution SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-for-Radiation-Oncology CY SEP 14-17, 2014 CL San Francisco, CA SP Amer Soc Radiat Oncol C1 [Liao, J. J.; Parvathaneni, U.; Laramore, G.] Univ Washington, Med Ctr, Seattle, WA 98195 USA. [Jewell, P.] Keesler AFB Dept Radiat Oncol, Biloxi, MS USA. [Polissar, N.] Univ Washington, Seattle, WA 98195 USA. [Wong, W.] San Antonio Mil Med Ctr, Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 EI 1879-355X J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PD SEP 1 PY 2014 VL 90 SU 1 MA 2845 BP S544 EP S545 PG 2 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA AP8LV UT WOS:000342331402062 ER PT J AU Lanigan, A Tompkins, AJ Rivera, A AF Lanigan, Alexander Tompkins, Andrew J. Rivera, Arnaldo TI Unilateral Ear and Temporomandibular Joint Discomfort Chondroblastoma of the temporal bone SO JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Editorial Material C1 [Lanigan, Alexander] San Antonio Mil Med Ctr, San Antonio, TX USA. [Tompkins, Andrew J.; Rivera, Arnaldo] Ft Belvoir Community Hosp, Dept Otolaryngol Head & Neck Surg, Ft Belvoir, VA USA. [Rivera, Arnaldo] Walter Reed Natl Mil Med Ctr, Dept Otolaryngol Head & Neck Surg, Bethesda, MD USA. RP Lanigan, A (reprint author), US Army, Med Corps, San Antonio Mil Med Ctr, 3551 Roger Brooks Dr, San Antonio, TX 78234 USA. EM alexander.e.lanigan.mil@mail.mil NR 6 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6181 EI 2168-619X J9 JAMA OTOLARYNGOL JI JAMA Otolaryngol-Head Neck Surg. PD SEP PY 2014 VL 140 IS 9 BP 873 EP 874 DI 10.1001/jamaoto.2014.1472 PG 2 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA AP8VS UT WOS:000342358000015 PM 25123358 ER PT J AU Jones, J Crete, J Neumeier, R AF Jones, Jenny Crete, Joan Neumeier, Robin TI A Case Report of Pink Breast Milk SO JOGNN-JOURNAL OF OBSTETRIC GYNECOLOGIC AND NEONATAL NURSING LA English DT Article DE Serratia marcescens; pink breast milk; breastfeeding ID SERRATIA-MARCESCENS OUTBREAK; CONTAMINATION; PUMPS; UNIT AB A woman presented for her postpartum examination alarmed about pink stains on her breast pads and on her infant's burp pads and diapers. The stains were also found in her breast pump and the infant's bottles. Out of concern, she stopped breastfeeding. The diagnosis was colonization of mother and infant with Serratia marcescens. They were managed conservatively without antibiotics. The mother was guided to restart breastfeeding. The infant resumed nursing and continued to thrive. C1 [Jones, Jenny; Crete, Joan; Neumeier, Robin] Tripler Army Med Ctr, Dept Ob Gyn, Honolulu, HI 96859 USA. RP Crete, J (reprint author), Tripler Army Med Ctr, Dept Ob Gyn, Honolulu, HI 96859 USA. EM aloharedo4me@gmail.com NR 19 TC 1 Z9 1 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0884-2175 EI 1552-6909 J9 JOGNN-J OBST GYN NEO JI JOGNN PD SEP-OCT PY 2014 VL 43 IS 5 BP 625 EP 630 DI 10.1111/1552-6909.12492 PG 6 WC Nursing; Obstetrics & Gynecology SC Nursing; Obstetrics & Gynecology GA AP9GH UT WOS:000342386500012 PM 25141908 ER PT J AU Doona, CJ Ghosh, S Feeherry, FF Ramirez-Peralta, A Huang, Y Chen, H Setlow, P AF Doona, C. J. Ghosh, S. Feeherry, F. F. Ramirez-Peralta, A. Huang, Y. Chen, H. Setlow, P. TI High pressure germination of Bacillus subtilis spores with alterations in levels and types of germination proteins SO JOURNAL OF APPLIED MICROBIOLOGY LA English DT Article DE Bacillus; germinant receptor; high pressure; spore germination; spores ID SUPERDORMANT SPORES; FOOD QUALITY; NUTRIENT; RECEPTORS; MECHANISMS; MICROSCOPY; RESISTANCE; MUTATION; DORMANT; SAFETY AB Aims: Examine effects of different levels and types of nutrient germinant receptors (GRs) and other germination proteins on Bacillus subtilis spore germination by a moderate high pressure (mHP) (150 megaPascals (MPa)) that triggers germination through GRs, and a very high pressure (vHP) (550 MPa) that triggers spore germination independent of GRs. Methods and Results: The Moderate HP (mHP) and vHP germination kinetics of B. subtilis spores with large variations in levels of GRs and other germination proteins, including the GerD protein and the SpoVA proteins that comprise a spore membrane channel that is likely opened by vHP were measured. Conclusions: GR levels were the major factor determining mHP germination rates. However, other factors modulated mHP germination rates including (i) relative levels of individual GRs (GerA, GerB, GerK), as mHP affected different GRs differently; (ii) levels of a recently identified small protein that may be a GR subunit; and (iii) a dominant negative mutation in gerD that eliminates GR-dependent nutrient germination. In contrast, the alterations in germination proteins had no major effect on vHP germination, except for reduction of SpoVA protein levels. Significance and Impact of the Study: With the increasing use of HP for food processing, this study provides new information on factors that modulate HP germination of spores for potential application of HP technology to achieve food sterility. C1 [Doona, C. J.; Feeherry, F. F.] US Army, Natick Soldier RD&E Ctr, Warfighter Directorate, Natick, MA 01760 USA. [Ghosh, S.; Ramirez-Peralta, A.; Setlow, P.] Univ Connecticut, Ctr Hlth, Dept Mol Biol & Biophys, Farmington, CT 06030 USA. [Huang, Y.; Chen, H.] Univ Delaware, Dept Anim & Food Sci, Newark, DE USA. RP Setlow, P (reprint author), Univ Connecticut, Ctr Hlth, Dept Mol Biol & Biophys, Farmington, CT 06030 USA. EM setlow@nso2.uchc.edu FU US Department of Defense Multi-disciplinary University Research Initiative award through the US Army Research Laboratory; US Army Research Office [W911NF-09-1-0286] FX This communication is based on work supported by a US Department of Defense Multi-disciplinary University Research Initiative award through the US Army Research Laboratory and the US Army Research Office under contract number W911NF-09-1-0286. We are grateful for the assistance of Stephanie Luu and Barbara Setlow in some aspects of this work. NR 46 TC 8 Z9 8 U1 3 U2 15 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1364-5072 EI 1365-2672 J9 J APPL MICROBIOL JI J. Appl. Microbiol. PD SEP PY 2014 VL 117 IS 3 BP 711 EP 720 DI 10.1111/jam.12557 PG 10 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA AP6VE UT WOS:000342215300011 PM 24891141 ER PT J AU Rushing, JF Little, DN AF Rushing, John F. Little, Dallas N. TI Static Creep and Repeated Load as Rutting Performance Tests for Airport HMA Mix Design SO JOURNAL OF MATERIALS IN CIVIL ENGINEERING LA English DT Article DE Rutting; Hot mix asphalt; Performance tests; Airfields; Flow number; Flow time; Creep test; Repeated load test; Asphalt pavement analyzer AB A performance test, rather than an empirical test, to evaluate rutting susceptibility is needed to accompany current volumetric property requirements of airport hot mix asphalt (HMA) designed using a superpave gyratory compactor. The new performance test will provide a level of confidence that pavement constructed using a selected HMA mixture will function according to its design. This paper presents results from a laboratory study to identify a performance test for accepting hot asphalt mixtures for constructing airport pavements designed for high tire pressure traffic. Performance tests intended to indicate rutting susceptibility were performed on 34 HMA mixtures. Twenty-nine of these mixtures met all aggregate and volumetric property requirements for airport pavement construction; the remaining five mixtures were designed with excessive percentage of natural sand (30%) as rut-susceptible mixtures. Results from asphalt pavement analyzer (APA), triaxial static creep, and triaxial repeated load tests are presented. Statistical analyses performed on the results indicate that the rate of increase in permanent strain and the flow time value determined from triaxial static creep testing provide the strongest correlation to APA simulated traffic rutting. (C) 2014 American Society of Civil Engineers. C1 [Rushing, John F.] US Army Engineer Res & Dev Ctr, Airfields & Pavements Branch, Vicksburg, MS 39180 USA. [Little, Dallas N.] Texas A&M Univ, College Stn, TX 77843 USA. RP Rushing, JF (reprint author), US Army Engineer Res & Dev Ctr, Airfields & Pavements Branch, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM john.f.rushing@usace.army.mil; d-little@tamu.edu FU FAA Airport Technology Research and Development Branch under the FAA-ERDC Interagency Agreement FX The study described in this paper was supported by the FAA Airport Technology Research and Development Branch under the FAA-ERDC Interagency Agreement. The authors would like to thank Mr. Tim McCaffrey, Mr. Kevin Taylor, and Mr. Lance Warnock of the United States Army Engineer Research and Development Center for their efforts with the specimen preparation and laboratory testing. The contents of the paper reflect the views of the authors, who are responsible for the facts and accuracy of the data presented within. The contents do not necessarily reflect the official views and policies of the FAA, the Engineer Research and Development Center, Department of the Army, or the Department of Defense. The paper does not constitute a standard, specification, or regulation. Permission to publish was granted by Director, Geotechnical and Structures Laboratory. NR 14 TC 3 Z9 3 U1 2 U2 14 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0899-1561 EI 1943-5533 J9 J MATER CIVIL ENG JI J. Mater. Civ. Eng. PD SEP PY 2014 VL 26 IS 9 AR 04014055 DI 10.1061/(ASCE)MT.1943-5533.0000952 PG 8 WC Construction & Building Technology; Engineering, Civil; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA AP7AX UT WOS:000342231000008 ER PT J AU Delaney, JS Lindsay, FN Taylor, S Herzog, GF AF Delaney, J. S. Lindsay, F. N. Taylor, S. Herzog, G. F. TI A wee fremdling relict SO METEORITICS & PLANETARY SCIENCE LA English DT Meeting Abstract CT 77th Annual Meeting of the Meteoritical-Society CY SEP 08-13, 2014 CL Casablanca, MOROCCO SP Meteorit Soc ID MICROMETEORITES C1 [Delaney, J. S.] Rutgers State Univ, Dept Geol Sci, Piscataway, NJ 08854 USA. [Delaney, J. S.; Lindsay, F. N.; Herzog, G. F.] Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 USA. [Taylor, S.] CRREL, Hanover, NH 03755 USA. NR 6 TC 0 Z9 0 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1086-9379 EI 1945-5100 J9 METEORIT PLANET SCI JI Meteorit. Planet. Sci. PD SEP PY 2014 VL 49 SU 1 SI SI BP A93 EP A93 PG 1 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA AP2PA UT WOS:000341914200090 ER PT J AU Quartana, PJ Wilk, JE Thomas, JL Bray, RM Olmsted, KLR Brown, JM Williams, J Kim, PY Clarke-Walper, K Hoge, CW AF Quartana, Phillip J. Wilk, Joshua E. Thomas, Jeffrey L. Bray, Robert M. Olmsted, Kristine L. Rae Brown, Janice M. Williams, Jason Kim, Paul Y. Clarke-Walper, Kristina Hoge, Charles W. TI Trends in Mental Health Services Utilization and Stigma in US Soldiers From 2002 to 2011 SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID NATIONAL-GUARD SOLDIERS; POSTTRAUMATIC-STRESS-DISORDER; PRIMARY-CARE; PSYCHOMETRIC PROPERTIES; AFGHANISTAN VETERANS; PTSD CHECKLIST; ARMED-FORCES; ACTIVE-DUTY; IRAQ WAR; BARRIERS AB Objectives. We characterized trends in mental health services utilization and stigma over the course of the Afghanistan and Iraq wars among active-component US soldiers. Methods. We evaluated trends in mental health services utilization and stigma using US Army data from the Health-Related Behavior (HRB) surveys from 2002, 2005, and 2008 (n = 12 835) and the Land Combat Study (LCS) surveys administered to soldiers annually from 2003 to 2009 and again in 2011 (n = 22 627). Results. HRB and LCS data suggested increased mental health services utilization and decreased stigma in US soldiers between 2002 and 2011. These trends were evident in soldiers with and without posttraumatic stress disorder (PTSD), major depressive disorder (MDD), or PTSD and MDD. Despite the improving trends, more than half of soldiers with mental health problems did not report seeking care. Conclusions. Mental health services utilization increased and stigma decreased over the course of the wars in Iraq and Afghanistan. Although promising, these findings indicate that a significant proportion of US soldiers meeting criteria for PTSD or MDD do not utilize mental health services, and stigma remains a pervasive problem requiring further attention. C1 [Quartana, Phillip J.; Wilk, Joshua E.; Thomas, Jeffrey L.; Kim, Paul Y.; Clarke-Walper, Kristina; Hoge, Charles W.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Bray, Robert M.; Olmsted, Kristine L. Rae; Brown, Janice M.; Williams, Jason] RTI Int, Res Triangle Pk, NC USA. RP Quartana, PJ (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM phillip.j.quartana2.civ@mail.mil NR 36 TC 7 Z9 7 U1 0 U2 10 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD SEP PY 2014 VL 104 IS 9 BP 1671 EP 1679 DI 10.2105/AJPH.2014.301971 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AP1XB UT WOS:000341864400033 PM 25033143 ER PT J AU Linden, K Stewart, IJ Kreyer, SFX Scaravilli, V Cannon, JW Cancio, LC Batchinsky, AI Chung, KK AF Linden, Katharina Stewart, Ian J. Kreyer, Stefan F. X. Scaravilli, Vittorio Cannon, Jeremy W. Cancio, Leopoldo C. Batchinsky, Andriy I. Chung, Kevin K. TI Extracorporeal blood purification in burns: A review SO BURNS LA English DT Review DE Thermal injury; Blood purification; Cytokine removal; Burns ID ACUTE KIDNEY INJURY; ACUTE-RENAL-FAILURE; CONTINUOUS VENOVENOUS HEMOFILTRATION; RANDOMIZED CONTROLLED-TRIAL; CRITICALLY-ILL PATIENTS; INTENSIVE-CARE-UNIT; SEPTIC SHOCK; VOLUME HEMOFILTRATION; REPLACEMENT THERAPY; CYTOKINE REMOVAL AB A prolonged and fulminant inflammatory state, with high levels of pro- and anti-inflammatory mediators, is seen after extensive thermal injury. Blood purification techniques including plasma exchange, continuous venovenous hemofiltration, and adsorbing membranes have the potential to modulate this response, thereby improving outcomes. This article describes the scientific rationale behind blood purification in burns and offers a review of literature regarding its potential application in this patient cohort. (C) 2014 Elsevier Ltd and ISBI. All rights reserved. C1 [Linden, Katharina; Kreyer, Stefan F. X.; Scaravilli, Vittorio; Cancio, Leopoldo C.; Batchinsky, Andriy I.; Chung, Kevin K.] US Army, Inst Surg Res, San Antonio, TX 78234 USA. [Stewart, Ian J.; Cannon, Jeremy W.] San Antonio Mil Med Ctr, San Antonio, TX 78234 USA. [Cannon, Jeremy W.; Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Cancio, Leopoldo C.] Univ Texas San Antonio, Hlth Sci Ctr, San Antonio, TX 78229 USA. RP Linden, K (reprint author), US Army, Inst Surg Res, San Antonio, TX 78234 USA. EM Katharina.Linden@ukb.uni-bonn.de FU U.S. Army Institute of Surgical Research (USAISR) FX This research was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Institute of Surgical Research (USAISR) administered by Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USAMRMC. NR 61 TC 1 Z9 2 U1 2 U2 12 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 EI 1879-1409 J9 BURNS JI Burns PD SEP PY 2014 VL 40 IS 6 BP 1071 EP 1078 DI 10.1016/j.burns.2014.01.013 PG 8 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA AP2JL UT WOS:000341898400002 PM 24548734 ER PT J AU Rademacher, N Bayarjargal, L Morgenroth, W Winkler, B Ciezak-Jenkins, J Batyrev, IG Milman, V AF Rademacher, Nadine Bayarjargal, Lkhamsuren Morgenroth, Wolfgang Winkler, Bjoern Ciezak-Jenkins, Jennifer Batyrev, Iskander G. Milman, Victor TI The Local Atomic Structures of Liquid CO at 3.6 GPa and Polymerized CO at 0 to 30 GPa from High-Pressure Pair Distribution Function Analysis SO CHEMISTRY-A EUROPEAN JOURNAL LA English DT Article DE carbon monoxide; high-pressure reactions; liquids; pair distribution functions; polymerization ID SPACE GAUSSIAN PSEUDOPOTENTIALS; SOLID CARBON-MONOXIDE; CHEMICAL-REACTIONS; ORIENTATIONAL CORRELATIONS; NITRIC-OXIDE; PHASE; TEMPERATURE; DIFFRACTION; CALIBRATION; DIOXIDE AB The local atomic structures of liquid and polymerized CO and its decomposition products were analyzed at pressures up to 30 GPa in diamond anvil cells by X-ray diffraction, pair distribution function (PDF) analysis, single-crystal diffraction, and Raman spectroscopy. The structural models were obtained by density functional calculations. Analysis of the PDF of a liquid CO-rich phase revealed that the local structure has a pronounced short-range order. The PDFs of polymerized amorphous CO at several pressures revealed the compression of the molecular structure; covalent bond lengths did not change significantly with pressure. Experimental PDFs could be reproduced with simulations from DFT-optimized structural models. Likely structural features of polymerized CO are thus 4- to 6-membered rings (lactones, cyclic ethers, and rings decorated with carbonyl groups) and long bent chains with carbonyl groups and bridging atoms. Laser heating polymerized CO at pressures of 7 to 9 GPa and 20 GPa resulted in the formation of CO2. C1 [Rademacher, Nadine; Bayarjargal, Lkhamsuren; Morgenroth, Wolfgang; Winkler, Bjoern] Goethe Univ Frankfurt, Inst Geowissensch, D-60438 Frankfurt, Germany. [Ciezak-Jenkins, Jennifer; Batyrev, Iskander G.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Milman, Victor] Dassault Syst, BIOVIA, Cambridge CB4 0WN, England. RP Rademacher, N (reprint author), Goethe Univ Frankfurt, Inst Geowissensch, D-60438 Frankfurt, Germany. EM Rademacher@kristall.uni-frankfurt.de RI Schrodt, Nadine/D-4756-2015; Milman, Victor/M-6117-2015; OI Schrodt, Nadine/0000-0001-6110-8320; Milman, Victor/0000-0003-2258-1347; Morgenroth, Wolfgang/0000-0001-8921-0052 FU BMBF [05 K10RFA, 05 K13RF1]; DFG [WI1232/25-1]; US Army Research Office [W911NF-12-2-0063]; International Centre of Diffraction Data FX The authors gratefully acknowledge financial support by the BMBF (projects 05 K10RFA and 05 K13RF1), the DFG (project WI1232/25-1), the US Army Research Office (contract W911NF-12-2-0063), and the International Centre of Diffraction Data. The authors acknowledge Prof. Dr. A. Woodland for access to the micro-Raman spectrometer and Prof. Dr. L. Ehm for helpful discussions. Part of the research was carried out at the light source PETRA III at DESY, a member of the Helmholtz Association HGF. We thank the beamline scientist of P02.2, H.-P. Liermann, and his team. NR 45 TC 6 Z9 6 U1 3 U2 24 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 0947-6539 EI 1521-3765 J9 CHEM-EUR J JI Chem.-Eur. J. PD SEP 1 PY 2014 VL 20 IS 36 BP 11531 EP 11539 DI 10.1002/chem.201403000 PG 9 WC Chemistry, Multidisciplinary SC Chemistry GA AO8UF UT WOS:000341629800037 PM 25066949 ER PT J AU Sul, B Wallqvist, A Morris, MJ Reifman, J Rakesh, V AF Sul, Bora Wallqvist, Anders Morris, Michael J. Reifman, Jaques Rakesh, Vineet TI A computational study of the respiratory airflow characteristics in normal and obstructed human airways SO COMPUTERS IN BIOLOGY AND MEDICINE LA English DT Article DE Obstructive lung diseases; Peripheral airways; Airflow pattern similarity measure; Wall shear stress; Computational fluid dynamics ID MODEL SYMMETRICAL BIFURCATION; HUMAN BRONCHIAL AIRWAYS; FLUID-DYNAMICS; HYPERPOLARIZED HE-3; PULMONARY-DISEASE; SHEAR-STRESS; HUMAN LUNGS; IN-VITRO; VENTILATION; DEPOSITION AB Obstructive lung diseases in the lower airways are a leading health concern worldwide. To improve our understanding of the pathophysiology of lower airways, we studied airflow characteristics in the lung between the 8th and the 14th generations using a three-dimensional computational fluid dynamics model, where we compared normal and obstructed airways for a range of breathing conditions. We employed a novel technique based on computing the Pearson's correlation coefficient to quantitatively characterize the differences in airflow patterns between the normal and obstructed airways. We found that the airflow patterns demonstrated clear differences between normal and diseased conditions for high expiratory flow rates ( > 2300 ml/s), but not for inspiratory flow rates. Moreover, airflow patterns subjected to filtering demonstrated higher sensitivity than airway resistance for differentiating normal and diseased conditions. Further, we showed that wall shear stresses were not only dependent on breathing rates, but also on the distribution of the obstructed sites in the lung: for the same degree of obstruction and breathing rate, we observed as much as two-fold differences in shear stresses. In contrast to previous studies that suggest increased wall shear stress due to obstructions as a possible damage mechanism for small airways, our model demonstrated that for flow rates corresponding to heavy activities, the wall shear stress in both normal and obstructed airways was < 0.3 Pa, which is within the physiological limit needed to promote respiratory defense mechanisms. In summary, our model enables the study of airflow characteristics that may be impractical to assess experimentally. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-rtc-nd/3.0/). C1 [Sul, Bora; Wallqvist, Anders; Reifman, Jaques; Rakesh, Vineet] US Army Med Res & Mat Command, Dept Def Biotechnol, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA. [Morris, Michael J.] San Antonio Mil Med Ctr, Dept Med, Ft Sam Houston, TX USA. RP Reifman, J (reprint author), US Army Med Res & Mat Command, Dept Def Biotechnol, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr,ATTN MCMR TT, 504 Scott St, Frederick, MD 21702 USA. EM jaques.reifman.civ@mail.mil OI wallqvist, anders/0000-0002-9775-7469 FU U.S. Army Network Science Initiative; U.S. Department of Defense Health Program FX This research was sponsored by the U.S. Army Network Science Initiative and a grant from the U.S. Department of Defense Health Program managed by the Military Operational Medicine Research Program, U.S. Army Medical Research and Materiel Command, Ft. Detrick, MD. NR 59 TC 4 Z9 5 U1 0 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0010-4825 EI 1879-0534 J9 COMPUT BIOL MED JI Comput. Biol. Med. PD SEP 1 PY 2014 VL 52 BP 130 EP 143 DI 10.1016/j.compbiomed.2014.06.008 PG 14 WC Biology; Computer Science, Interdisciplinary Applications; Engineering, Biomedical; Mathematical & Computational Biology SC Life Sciences & Biomedicine - Other Topics; Computer Science; Engineering; Mathematical & Computational Biology GA AP2LF UT WOS:000341903000017 PM 25058489 ER PT J AU Lee, DJ Warner, CH Hoge, CW AF Lee, Daniel J. Warner, Christopher H. Hoge, Charles W. TI Advances and Controversies in Military Posttraumatic Stress Disorder Screening SO CURRENT PSYCHIATRY REPORTS LA English DT Article DE PTSD; Posttraumatic stress disorder; Screening; Epidemiology; Force screening; US military; Readiness; Deployment; Combat; Prevalence; Positive predictive value; Negative predictive value; Sensitivity; Specificity; DoD; VA; NDAA; CAPS; SPRINT; DTS; PCL; PTSD Checklist; Davidson Trauma Scale ID RANDOMIZED CONTROLLED-TRIAL; MENTAL-HEALTH PROBLEMS; DAVIDSON TRAUMA SCALE; PTSD CHECKLIST PCL; PSYCHOMETRIC PROPERTIES; PRIMARY-CARE; CLINICAL-TRIAL; DOUBLE-BLIND; COMBAT; PLACEBO AB As the longest war in American history draws to a close, an unprecedented number of service members and veterans are seeking care for health challenges related to transitioning home and to civilian life. Congressionally mandated screening for mental health concerns in the Department of Defense (DoD), as well as screening efforts Veterans Affairs (VA) facilities, has been established with the goal of decreasing stigma and ensuring service members and veterans with depression and posttraumatic stress disorder (PTSD) receive needed treatment. Both the DoD and VA have also developed integrated behavioral health in primary-care based initiatives, which emphasize PTSD screening, treatment, and care coordination. This article discusses the rationale for population-level deployment-related mental health screening, recent changes to screening frequency, commonly used screening instruments such as the primary care PTSD screen (PC-PTSD), PTSD checklist (PCL), and Davidson Trauma Scale (DTS); as well as the strengths/limitations of each, and recommended cut-off scores based on expected PTSD prevalence. C1 [Lee, Daniel J.] Bayne Jones Army Community Hosp, Dept Behav Hlth, Ft Polk, LA 71459 USA. [Warner, Christopher H.] 101st Airborne Div, Ft Campbell, KY 42223 USA. [Hoge, Charles W.] Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Lee, DJ (reprint author), Bayne Jones Army Community Hosp, Dept Behav Hlth, Ft Polk, LA 71459 USA. EM Daniel.J.Lee82.mil@mail.mil; Christopher.H.Warner.mil@mail.mil; Charles.W.Hoge.civ@mail.mil NR 50 TC 2 Z9 2 U1 1 U2 17 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1523-3812 EI 1535-1645 J9 CURR PSYCHIAT REP JI Curr. Psychiatry Rep. PD SEP PY 2014 VL 16 IS 9 AR 467 DI 10.1007/s11920-014-0467-7 PG 6 WC Psychiatry SC Psychiatry GA AP1KF UT WOS:000341827400005 PM 25023512 ER PT J AU Manar, F Medina, A Jones, AR AF Manar, Field Medina, Albert Jones, Anya R. TI Tip vortex structure and aerodynamic loading on rotating wings in confined spaces SO EXPERIMENTS IN FLUIDS LA English DT Article ID LEADING-EDGE VORTICES; INSECT FLIGHT AB Experiments on a rotating wing in a liquid-filled tank were conducted to determine the minimum required tip clearance to produce data free from wall effects. A rotating wing fixed at an angle of attack of 45 degrees was revolved for two revolutions at Reynolds numbers between 120 and 10,000. Tip clearance was varied from 0.5 to 5 chords by varying wing size, while also varying wing speed to hold Reynolds number constant. Force measurements on the wing, as well as dye flow visualization and particle image velocimetry of the entire tank, were conducted. Tip clearances of 0.5-7 chords were also tested computationally. Results of all measurements show large tip effects for 0.5 chords of tip clearance, and no wall effects for 5 chords of tip clearance at all Reynolds numbers tested. The 3 chord clearance case showed negligible wall effects in both the particle image velocimetry and dye flow visualization for all Reynolds numbers observed. The forces on the 3 chord tip clearance wing indicate wall effects appearing in the second revolution for Reynolds numbers of >1,000. A tip clearance of 5 chords is deemed to be free of wall effects for experiments limited to two wing revolutions within the range of tested Reynolds numbers. C1 [Manar, Field; Jones, Anya R.] Univ Maryland, Dept Aerosp Engn, College Pk, MD 20742 USA. [Medina, Albert] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Manar, F (reprint author), Univ Maryland, Dept Aerosp Engn, College Pk, MD 20742 USA. EM fmanar@umd.edu; medina@umd.edu; arjones@umd.edu FU Air Force Office of Scientific Research (AFOSR) Young Investigator Program [FA9550-12-1-0251] FX The authors would like to recognize Peter Mancini and Andrew Lind for their assistance in data collection and reduction. This work was supported by the Air Force Office of Scientific Research (AFOSR) Young Investigator Program (FA9550-12-1-0251). NR 19 TC 7 Z9 7 U1 0 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0723-4864 EI 1432-1114 J9 EXP FLUIDS JI Exp. Fluids PD SEP PY 2014 VL 55 IS 9 AR UNSP 1815 DI 10.1007/s00348-014-1815-4 PG 18 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA AP6FK UT WOS:000342172800013 ER PT J AU Torrieri, D AF Torrieri, Don TI Direction Finding of a Compromised Node in a Wireless Network SO IEEE TRANSACTIONS ON MOBILE COMPUTING LA English DT Article DE Compromised node; direction finding; spread spectrum ID DOA ESTIMATION; WAVE-FORMS; SIGNALS AB When a spread-spectrum receiver in a network discovers that it is processing a jamming signal transmitted by a compromised node, its first response is to attempt to identify the compromised node. In this paper, an adaptive array is used to find the direction to the jamming source despite the presence of interference signals transmitted by both legitimate network nodes and external sources. Unlike other direction-finding algorithms, the desired-signal classification (DESIC) algorithm requires no information or special assumptions about the interference signals to effectively cancel them and find the desired direction. Simulation experiments show that the DESIC algorithm provides an excellent performance in many scenarios, even when the received signals cannot be resolved by the widely used MUSIC algorithm. C1 US Army, Res Lab, Adelphi, MD 20783 USA. RP Torrieri, D (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA. EM don.j.torrieri.civ@mail.mil NR 14 TC 0 Z9 0 U1 0 U2 3 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1536-1233 EI 1558-0660 J9 IEEE T MOBILE COMPUT JI IEEE. Trans. Mob. Comput. PD SEP PY 2014 VL 13 IS 9 BP 1995 EP 2002 DI 10.1109/TMC.2013.52 PG 8 WC Computer Science, Information Systems; Telecommunications SC Computer Science; Telecommunications GA AP6BI UT WOS:000342162100007 ER PT J AU Ketter, PM Guentzel, MN Schaffer, B Herzig, M Wu, XW Montgomery, RK Parida, BK Fedyk, CG Yu, JJ Jorgensen, J Chambers, JP Cap, AP Arulanandam, BP AF Ketter, Patrick M. Guentzel, M. Neal Schaffer, Beverly Herzig, Maryanne Wu, Xiaowu Montgomery, Robbie K. Parida, Bijaya K. Fedyk, Chriselda G. Yu, Jieh-Juen Jorgensen, James Chambers, James P. Cap, Andrew P. Arulanandam, Bernard P. TI Severe Acinetobacter baumannii Sepsis Is Associated with Elevation of Pentraxin 3 SO INFECTION AND IMMUNITY LA English DT Article ID HUMORAL INNATE IMMUNITY; REGULATES TISSUE FACTOR; PSEUDOMONAS-AERUGINOSA; ASPERGILLUS-FUMIGATUS; CLOTTING ACTIVATION; PULMONARY INFECTION; DIGESTIVE-TRACT; PTX3; INJURY; INFLAMMATION AB Multidrug-resistant Acinetobacter baumannii is among the most prevalent bacterial pathogens associated with trauma-related wound and bloodstream infections. Although septic shock and disseminated intravascular coagulation have been reported following fulminant A. baumannii sepsis, little is known about the protective host immune response to this pathogen. In this study, we examined the role of PTX3, a soluble pattern recognition receptor with reported antimicrobial properties and stored within neutrophil granules. PTX3 production by murine J774a.1 macrophages was assessed following challenge with A. baumannii strains ATCC 19606 and clinical isolates (CI) 77, 78, 79, 80, and 86. Interestingly, only CI strains 79, 80, and 86 induced PTX3 synthesis in murine J774a.1 macrophages, with greatest production observed following CI 79 and 86 challenge. Subsequently, C57BL/6 mice were challenged intraperitoneally with CI 77 and 79 to assess the role of PTX3 in vivo. A. baumannii strain CI 79 exhibited significantly (P < 0.0005) increased mortality, with an approximate 50% lethal dose (LD50) of 10(5) CFU, while an equivalent dose of CI 77 exhibited no mortality. Plasma leukocyte chemokines (KC, MCP-1, and RANTES) and myeloperoxidase activity were also significantly elevated following challenge with CI 79, indicating neutrophil recruitment/activation associated with significant elevation in serum PTX3 levels. Furthermore, 10-fold-greater PTX3 levels were observed in mouse serum 12 h postchallenge, comparing CI 79 to CI 77 (1,561 ng/ml versus 145 ng/ml), with concomitant severe pathology (liver and spleen) and coagulopathy. Together, these results suggest that elevation of PTX3 is associated with fulminant disease during A. baumannii sepsis. C1 [Ketter, Patrick M.; Guentzel, M. Neal; Yu, Jieh-Juen; Chambers, James P.; Arulanandam, Bernard P.] Univ Texas San Antonio, San Antonio, TX 78249 USA. [Schaffer, Beverly; Herzig, Maryanne; Wu, Xiaowu; Montgomery, Robbie K.; Parida, Bijaya K.; Fedyk, Chriselda G.; Cap, Andrew P.] US Army, Inst Surg Res, San Antonio Mil Med Ctr, San Antonio, TX USA. [Jorgensen, James] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. RP Arulanandam, BP (reprint author), Univ Texas San Antonio, San Antonio, TX 78249 USA. EM bernard.arulanandam@utsa.edu RI Arulanandam, Bernard/O-9501-2014 FU U.S. Army Medical Research and Material Command; Army Research Office of the Department of Defense [W911NF-11-1-0136]; Alvarez Graduate Research Education Excellence Fund FX This research was partially funded by the U.S. Army Medical Research and Material Command, the Army Research Office of the Department of Defense (contract W911NF-11-1-0136), and the Alvarez Graduate Research Education Excellence Fund. NR 68 TC 4 Z9 4 U1 0 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 EI 1098-5522 J9 INFECT IMMUN JI Infect. Immun. PD SEP PY 2014 VL 82 IS 9 BP 3910 EP 3918 DI 10.1128/IAI.01958-14 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AP2VB UT WOS:000341932700039 PM 25001601 ER PT J AU Schmidt, PM Sheridan, RL Moore, CL Scuba, SC King, BT Morrissey, PM Cancio, LC AF Schmidt, Patricia M. Sheridan, Robert L. Moore, Christina L. Scuba, Steve C. King, Booker T. Morrissey, Paul M. Cancio, Leopoldo C. TI From Baghdad to Boston: International Transfer of Burned Children in Time of War SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID CARE; IRAQ; AFGHANISTAN AB A large portion of the casualties admitted to military hospitals on the battlefield in Iraq consists of children, of whom 13% had burns. The U. S. Army Combat Support Hospital (CSH) in Baghdad, faced with an influx of such patients, successfully transferred selected burned children by commercial airlines to the Shriners Hospital for Children in Boston, Massachusetts (SHC-B). The authors aimed to document this process, from both an ethical and a procedural standpoint. Care was conducted in six phases: 1) admission to the CSH; 2) selection for transfer; 3) burn care at the CSH; 4) travel to the United States; 5) burn care at the SHC-B; 6) return to Iraq. Transfer and SHC-B care were funded by charitable organizations. A review of patient records was performed. Eight acutely burned pediatric patients participated in this program. All were successfully transferred, treated at SHC-B, and returned to Iraq. They ranged in age from 1.7 to 17 years and in burn size from 6 to 53% of the TBSA. At SHC-B, the hospital length of stay was 14 to 132 days; up to 23 visits to the operating room were performed for acute and reconstructive burn surgery. The cost of war includes the care of injured civilians, and includes burned children. For selected patients, transfer out of the combat zone is one method of fulfilling this obligation. C1 [Schmidt, Patricia M.; Moore, Christina L.; King, Booker T.; Cancio, Leopoldo C.] US Army Inst Surg Res, Burn Ctr, Ft Sam Houston, TX 78234 USA. [Sheridan, Robert L.] Shriners Hosp Children, Burn Surg Serv, Boston, MA USA. [Sheridan, Robert L.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Scuba, Steve C.] Walter Reed Natl Mil Med Ctr, Dept Nursing, Bethesda, MD USA. [Morrissey, Paul M.] US Army Med Act, Dept Pediat, Ft Drum, NY USA. RP Cancio, LC (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. FU Iraqi Children's Project FX P.M.M. is the president of the Iraqi Children's Project, a not-for-profit corporation that paid travel and living expenses for the children in this study. He does not receive salary or other benefits from the corporation, and he does not have any ownership interest in it. The other authors declare no conflict of interest. NR 17 TC 2 Z9 2 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X EI 1559-0488 J9 J BURN CARE RES JI J. Burn Care Res. PD SEP-OCT PY 2014 VL 35 IS 5 BP 369 EP 373 DI 10.1097/BCR.0b013e3182a366f1 PG 5 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA AP5CZ UT WOS:000342098600018 PM 24121805 ER PT J AU Giretzlehner, M Haller, HL Faucher, LD Pressman, MA Salinas, J Jeng, JC AF Giretzlehner, Michael Haller, Herbert L. Faucher, Lee D. Pressman, Melissa A. Salinas, Jose Jeng, James C. TI One Burn, One Standard SO JOURNAL OF BURN CARE & RESEARCH LA English DT Letter C1 [Giretzlehner, Michael] Johannes Kepler Univ Linz, Software GmbH, Res Dept Med Informat, A-4232 Hagenberg, Austria. [Haller, Herbert L.] Trauma Hosp Linz AUVA, Linz, Austria. [Faucher, Lee D.] Univ Wisconsin, Madison, WI USA. [Pressman, Melissa A.] Arizona Burn Ctr, Phoenix, AZ USA. [Salinas, Jose] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Jeng, James C.] Catholic Univ Amer, MedStar Washington Hosp Ctr, Washington, DC 20064 USA. RP Giretzlehner, M (reprint author), Johannes Kepler Univ Linz, RISC Software GmbH, Res Dept Med Informat, Softwarepk 35, A-4232 Hagenberg, Austria. NR 3 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X EI 1559-0488 J9 J BURN CARE RES JI J. Burn Care Res. PD SEP-OCT PY 2014 VL 35 IS 5 BP E372 EP E372 DI 10.1097/BCR.0000000000000004 PG 1 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA AP5CZ UT WOS:000342098600014 PM 25144809 ER PT J AU Jin, XN Luong, TL Reese, N Gaona, H Collazo-Velez, V Vuong, C Potter, B Sousa, JC Olmeda, R Li, QG Xie, LS Zhang, J Zhang, P Reichard, G Melendez, V Marcsisin, SR Pybus, BS AF Jin, Xiannu Thu-Lan Luong Reese, Necole Gaona, Heather Collazo-Velez, Vanessa Chau Vuong Potter, Brittney Sousa, Jason C. Olmeda, Raul Li, Qigui Xie, Lisa Zhang, Jing Zhang, Ping Reichard, Greg Melendez, Victor Marcsisin, Sean R. Pybus, Brandon S. TI Comparison of MDCK-MDR1 and Caco-2 cell based permeability assays for anti-malarial drug screening and drug investigations SO JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS LA English DT Article DE MDCK-MDR1; Caco-2; Permeability; MDCK; Anti-malarial drug development; Primaquine-Chloroquine interaction ID BLOOD-BRAIN-BARRIER; P-GLYCOPROTEIN; TRANSEPITHELIAL TRANSPORT; IN-VITRO; MDCK; CHLOROQUINE; MEFLOQUINE; PROBE; ABSORPTION; PRIMAQUINE AB Introduction: Malaria is a major health concern and affects over 300 million people a year. Accordingly, there is an urgent need for new efficacious anti-malarial drugs. A major challenge in developing new anti-malarial drugs is to design active molecules that have preferable drug-like characteristics. These "drug-like" characteristics include physiochemical properties that affect drug absorption, distribution, metabolism, and excretion (ADME). Compounds with poor ADME profiles will likely fail in vivo due to poor pharmacokinetics and/or other drug delivery related issues. There have been numerous assays developed in order to pre-screen compounds that would likely fail in further development due to poor absorption properties including PAMPA, Caco-2, and MDCK permeability assays. Methods: The use of cell-based permeability assays such as Caco-2 and MDCK serve as surrogate indicators of drug absorption and transport, with the two approaches often used interchangeably. We sought to evaluate both approaches in support of anti-malarial drug development. Accordingly, a comparison of both assays was conducted utilizing apparent permeability coefficient (P-app) values determined from liquid chromatography/tandem mass spectrometry (LC-MS) analyses. Results: Both Caco-2 and MDCK permeability assays produced similar P-app results for potential anti-malarial compounds with low- and medium permeability. Differences were observed for compounds with high permeability and compounds that were P-gp substrates. Additionally, the utility of MDCK-MDR1 permeability measurements was demonstrated in probing the role of P-glycoprotein transport in Primaquine-Chloroquine drug-drug interactions in comparison with in vivo pharmacokinetic changes. Discussion: This study provides an in-depth comparison of the Caco-2 and MDCK-MDR1 cell based permeability assays and illustrates the utility of cell-based permeability assays in antimalarial drug screening/development in regard to understanding transporter mediated changes in drug absorption/distribution. Published by Elsevier Inc. C1 [Jin, Xiannu; Thu-Lan Luong; Reese, Necole; Gaona, Heather; Collazo-Velez, Vanessa; Chau Vuong; Potter, Brittney; Sousa, Jason C.; Olmeda, Raul; Li, Qigui; Xie, Lisa; Zhang, Jing; Zhang, Ping; Reichard, Greg; Melendez, Victor; Marcsisin, Sean R.; Pybus, Brandon S.] Walter Reed Army Inst Res, Dept Drug Dev, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Marcsisin, SR (reprint author), Walter Reed Army Inst Res, Dept Drug Dev, Div Expt Therapeut, Silver Spring, MD 20910 USA. EM sean.r.marcsisin.mil@mail.mil FU Military Infectious Diseases Research Program project [Q0302_12_WR_CS] FX The views, opinions, and/or findings contained in this work are those of the authors and do not necessarily reflect the view of the Department of Defense and should not be construed as an official DoD/Army position. No official endorsement should be made. This work was supported in part by the Military Infectious Diseases Research Program project #Q0302_12_WR_CS. NR 25 TC 6 Z9 6 U1 0 U2 11 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1056-8719 EI 1873-488X J9 J PHARMACOL TOX MET JI J. Pharmacol. Toxicol. Methods PD SEP-OCT PY 2014 VL 70 IS 2 BP 188 EP 194 DI 10.1016/j.vascn.2014.08.002 PG 7 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA AP5ZU UT WOS:000342158000009 PM 25150934 ER PT J AU Wilson, DK Pettit, CL Ostashev, VE Vecherin, SN AF Wilson, D. Keith Pettit, Chris L. Ostashev, Vladimir E. Vecherin, Sergey N. TI Description and quantification of uncertainty in outdoor sound propagation calculations SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID WAVE-PROPAGATION; ATMOSPHERE; TURBULENCE; MODEL; PREDICTIONS; SCATTERING; BOUNDARY; NOISE AB The accuracy of outdoor sound propagation predictions is often limited by imperfect knowledge of the atmospheric and ground properties, and random environmental variations such as turbulence. This article describes the impact of such uncertainties, and how they can be efficiently addressed and quantified with stochastic sampling techniques such as Monte Carlo and Latin hypercube sampling (LHS). Extensions to these techniques, such as importance sampling based on simpler, more efficient propagation models, and adaptive importance sampling, are described. A relatively simple example problem involving the Lloyd's mirror effect for an elevated sound source in a homogeneous atmosphere is considered first, followed by a more complicated example involving near-ground sound propagation with refraction and scattering by turbulence. When uncertainties in the atmospheric and ground properties dominate, LHS with importance sampling is found to converge to an accurate estimate with the fewest samples. When random turbulent scattering dominates, the sampling method has little impact. A comprehensive computational approach is demonstrated that is both efficient and accurate, while simultaneously incorporating broadband sources, turbulent scattering, and uncertainty in the environmental properties. C1 [Wilson, D. Keith; Ostashev, Vladimir E.; Vecherin, Sergey N.] US Army Engineer Res & Dev Ctr, Hanover, NH 03755 USA. [Pettit, Chris L.] US Naval Acad, Dept Aerosp Engn, Annapolis, MD 21402 USA. RP Wilson, DK (reprint author), US Army Engineer Res & Dev Ctr, Hanover, NH 03755 USA. EM d.keith.wilson@usace.army.mil RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 FU U.S. Army Engineer Research and Development Center, Geospatial Research and Engineering Business Area FX This research was supported by the U.S. Army Engineer Research and Development Center, Geospatial Research and Engineering Business Area. Permission to publish was granted by Director, Cold Regions Research and Engineering Laboratory. NR 40 TC 0 Z9 0 U1 0 U2 6 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 EI 1520-8524 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD SEP PY 2014 VL 136 IS 3 BP 1013 EP 1028 DI 10.1121/1.4890644 PG 16 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA AP6RQ UT WOS:000342205700015 PM 25190377 ER PT J AU Ferro, A Mullens, K Randall, S AF Ferro, Allison Mullens, Katrina Randall, Seth TI Decreasing Inpatient Length of Stay at a Military Medical Treatment Facility SO NURSING CLINICS OF NORTH AMERICA LA English DT Article DE Inpatient; Length of stay; Evidence-based practice; Discharge planning ID DISCHARGE AB This article describes an evidence-based approach to decreasing the length of stay of inpatient adults on the medicine oncology ward of a large urban military medical center. A strong and diverse team was formed, which worked together for the length of the project. A formalized approach involving weekly discharge-planning meetings with a discharge advocate as the planner, coupled with solid documentation, was adopted. There was a decrease in the average length of stay on the inpatient wards, resulting in cost savings for the facility. This approach using strong evidence can overcome institutional challenges, with a positive impact on patient care. C1 [Ferro, Allison; Mullens, Katrina; Randall, Seth] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Ferro, A (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM allison.l.ferro.mil@mail.mil FU Hawaii State Center for Nursing. Medical Oncology, Tripler Army Medical Center, Honolulu, HI FX Disclosure: Commercial support was received in part from the Hawaii State Center for Nursing. Medical Oncology, Tripler Army Medical Center, 1 Jarrett White Road, Honolulu, HI 96859, USA NR 11 TC 0 Z9 0 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0029-6465 EI 1558-1357 J9 NURS CLIN N AM JI Nurs. Clin. North Am. PD SEP PY 2014 VL 49 IS 3 BP 309 EP + DI 10.1016/j.cnur.2014.05.005 PG 13 WC Nursing SC Nursing GA AP6IP UT WOS:000342181200007 PM 25155531 ER PT J AU Laubach, V Wilhelm, P Carter, K AF Laubach, Vickie Wilhelm, Patricia Carter, Katie TI Shhh ... I'm Growing: Noise in the NICU SO NURSING CLINICS OF NORTH AMERICA LA English DT Article DE Noise; Preterm; Neonatal; Neonatal intensive care unit; Newborns; Infants; Sound; Sound levels ID INTENSIVE-CARE-UNIT; ENVIRONMENT; NEWBORNS; INFANT AB Attempting to mitigate operational and structural noise is important in improving the outcomes of high-risk preterm infants. It was anticipated that a culture change in nursing behaviors to include "Quiet Time" would result in reducing the noise levels towards the National Recommended Safe Sound Level. This culture change alone was inadequate to meet NRL. Both operational and structural changes were also required in order to provide a safer neurophysiological environment for the rest and growth of the neonate. C1 [Laubach, Vickie; Wilhelm, Patricia; Carter, Katie] Tripler Army Med Ctr, Neonatal Intens Care Unit, Honolulu, HI 96859 USA. RP Laubach, V (reprint author), Tripler Army Med Ctr, Neonatal Intens Care Unit, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM alaub41324@aol.com FU Hawaii State Center for Nursing FX The authors acknowledge the Hawaii State Center for Nursing for their support of this project. NR 22 TC 2 Z9 2 U1 2 U2 9 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0029-6465 EI 1558-1357 J9 NURS CLIN N AM JI Nurs. Clin. North Am. PD SEP PY 2014 VL 49 IS 3 BP 329 EP + DI 10.1016/j.cnur.2014.05.007 PG 18 WC Nursing SC Nursing GA AP6IP UT WOS:000342181200009 PM 25155533 ER PT J AU Guda, T Darr, A Silliman, DT Magno, MHR Wenke, JC Kohn, J Baer, PRB AF Guda, Teja Darr, Aniq Silliman, David T. Magno, Maria H. R. Wenke, Joseph C. Kohn, Joachim Baer, Pamela R. Brown TI Methods to Analyze Bone Regenerative Response to Different rhBMP-2 Doses in Rabbit Craniofacial Defects SO TISSUE ENGINEERING PART C-METHODS LA English DT Article ID TISSUE-ENGINEERED CONSTRUCTS; MICRO-COMPUTED TOMOGRAPHY; MICROCOMPUTED TOMOGRAPHY; CALVARIAL DEFECTS; IN-VIVO; POLYCARBONATE SCAFFOLDS; EXPERIMENTAL-MODEL; COMPOSITE; ANGIOGENESIS; CRANIOPLASTY AB Multiple assessment methods are available to evaluate the performance of engineered scaffolds in accepted bone healing animal models. Evaluation and comparison of these methods can aid in the planning of future animal studies, as well as, inform clinical assessments as the engineered scaffolds translate into clinical studies and applications. To evaluate multiple bone assessment techniques, bone regrowth potential of tyrosine-derived polycarbonate (TyrPC) scaffolds loaded with various dosages of recombinant human bone morphogenetic protein-2 (rhBMP-2) (0, 10, 25, and 50 mu g) was assessed after 16 weeks in vivo in a rabbit calvarial model. Traditional X-ray radiography and micro-computed tomography (micro-CT) analyses were used to quantify the volume and density of regenerated bone. Histomorphometric analysis was performed as the traditional gold standard of evaluation. While these techniques are fairly standard in bone tissue engineering, we also investigated 64-slice CT, a tool more commonly used clinically, for comparison and to guide translational efforts. The 64-slice CT scans were carried out at 4 and 16 weeks to monitor temporal bone healing patterns. Study results indicated a clear dose-dependent response of increasing regenerated bone volume with rhBMP-2 loaded on the TyrPC scaffolds after 16 weeks of implantation. Significantly more bone formation was observed at the highest dose of rhBMP-2 (50 mu g), which is 25-50% of the previously recommended dose (100-200 mu g) for this defect. A significant difference was observed between the lowest and highest doses using radiographs (p < 0.001), micro-CT (p = 0.002), and CT (p < 0.001) and a high correlation was found between techniques (R-2 values between 0.446 and 0.911). It was found that the number of animals required per group to detect significant dose effects ranged between 6 and 8 for the imaging methods while histomorphometric analysis would require 25 animals per group to detect similar differences (desired power = 0.9, alpha = 0.05). Radiographic analysis provided quantifiable % defect coverage and radio-opacity, micro-CT provided spatial volumetric and bone density measures, histomorphometry provided biological confirmation, and 64-slice CT allowed for establishing of clinically relevant translational guidelines. These methodologies allow for a standardized and comprehensive description of bone regeneration and provide guidelines for the planning of future preclinical and clinical studies. C1 [Guda, Teja; Silliman, David T.; Baer, Pamela R. Brown] US Army, Inst Surg Res, Dept Craniomaxillofacial Regenerat Med Dent & Tra, Ft Sam Houston, TX 78234 USA. [Guda, Teja] Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX USA. [Darr, Aniq; Magno, Maria H. R.; Kohn, Joachim] Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ USA. [Darr, Aniq; Magno, Maria H. R.; Kohn, Joachim] Rutgers State Univ, New Jersey Ctr Biomat, Piscataway, NJ USA. [Wenke, Joseph C.] US Army, Inst Surg Res, Dept Extrem Trauma & Regenerat Med, Ft Sam Houston, TX 78234 USA. US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Rutgers State Univ, Piscataway, NJ USA. RP Baer, PRB (reprint author), US Army, Inst Surg Res, Dept Craniomaxillofacial Regenerat Med Dent & Tra, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM pamela.r.brownbaer.civ@mail.mil OI Brown Baer, Pamela/0000-0001-6964-1955; Guda, Teja/0000-0002-3218-2916 FU Armed Forces Institute of Regenerative Medicine (AFIRM) [W81XWH-08-2-0034]; U.S. Army of Surgical Research; USMRAA [W81XWH-13-P-0075]; U.S. Army Medical Research Acquisition Activity, 820 Chandler St., Fort Detrick, MD FX This research was sponsored in part by the Armed Forces Institute of Regenerative Medicine (AFIRM) award number W81XWH-08-2-0034 for which the U.S. Army Medical Research Acquisition Activity, 820 Chandler St., Fort Detrick, MD 21702-5014, is the awarding and administering acquisition office. This research was also supported in part by the U.S. Army of Surgical Research. T. G. would like to acknowledge support from USMRAA Grant number W81XWH-13-P-0075. The authors would like to acknowledge the assistance of Dr. Amit Vasanji, ImageIQ, with the 64-slice CT data analysis, and the assistance of Mr. Sean McBride, Dr. Jinku Kim, and Dr. Jeffry Hollinger, Carnegie Mellon University, with the preparation of the histological slides. The kind permission and support of the USAF Dental Evaluation and Consultation Service (DECS), Ft. Sam Houston, TX, Joint Base San Antonio for the use of the Skyscan 1072 micro-CT scanner and the Olympus microscope is also gratefully acknowledged. This study was conducted in compliance with the Animal Welfare Act and the Implementing Animal Welfare Regulations and in accordance with the principles of the Guide for the Care and Use of Laboratory Animals. All animal procedures were approved by the U.S. Army Institute of Surgical Research Animal Care and Use Committee. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official positions or as reflecting the views of the Department of the Army or the Department of Defense. NR 33 TC 2 Z9 2 U1 1 U2 16 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1937-3384 EI 1937-3392 J9 TISSUE ENG PART C-ME JI Tissue Eng. Part C-Methods PD SEP PY 2014 VL 20 IS 9 BP 749 EP 760 DI 10.1089/ten.tec.2013.0581 PG 12 WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology SC Cell Biology; Biotechnology & Applied Microbiology GA AP1KU UT WOS:000341829500007 PM 24422668 ER PT J AU Neiberg, MS AF Neiberg, Michael S. TI The Sleepwalkers: How Europe Went to War in 1914 SO JOURNAL OF MODERN HISTORY LA English DT Book Review C1 [Neiberg, Michael S.] US Army War Coll, Carlisle, PA 17013 USA. RP Neiberg, MS (reprint author), US Army War Coll, Carlisle, PA 17013 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-2801 EI 1537-5358 J9 J MOD HIST JI J. Mod. Hist. PD SEP PY 2014 VL 86 IS 3 BP 654 EP 655 PG 3 WC History SC History GA AO7DX UT WOS:000341513400015 ER PT J AU Torres, OB Jalah, R Rice, KC Li, FY Antoline, JFG Iyer, MR Jacobson, AE Boutaghou, MN Alving, CR Matyas, GR AF Torres, Oscar B. Jalah, Rashmi Rice, Kenner C. Li, Fuying Antoline, Joshua F. G. Iyer, Malliga R. Jacobson, Arthur E. Boutaghou, Mohamed Nazim Alving, Carl R. Matyas, Gary R. TI Characterization and optimization of heroin hapten-BSA conjugates: method development for the synthesis of reproducible hapten-based vaccines SO ANALYTICAL AND BIOANALYTICAL CHEMISTRY LA English DT Article DE Hapten density; Drugs of abuse vaccines; TNBS; Ellman's test; MALDI-TOFMS; ELISA ID IONIZATION-MASS-SPECTROMETRY; SIMPLE CHEMICAL-COMPOUNDS; ANTIBODY REACTIONS; PROTEINS; BINDING; MORPHINE; ANTIGEN; ACID; SENSITIZATION; KINETICS AB A potential new treatment for drug addiction is immunization with vaccines that induce antibodies that can abrogate the addictive effects of the drug of abuse. One of the challenges in the development of a vaccine against drugs of abuse is the availability of an optimum procedure that gives reproducible and high yielding hapten-protein conjugates. In this study, a heroin/morphine surrogate hapten (MorHap) was coupled to bovine serum albumin (BSA) using maleimide-thiol chemistry. MorHap-BSA conjugates with 3, 5, 10, 15, 22, 28, and 34 haptens were obtained using different linker and hapten ratios. Using this optimized procedure, MorHap-BSA conjugates were synthesized with highly reproducible results and in high yields. The number of haptens attached to BSA was compared by 2,4,6-trinitrobenzenesulfonic acid (TNBS) assay, modified Ellman's test and matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). Among the three methods, MALDI-TOF MS discriminated subtle differences in hapten density. The effect of hapten density on enzyme-linked immunosorbent assay (ELISA) performance was evaluated with seven MorHap-BSA conjugates of varying hapten densities, which were used as coating antigens. The highest antibody binding was obtained with MorHap-BSA conjugates containing 3-5 haptens. This is the first report that rigorously analyzes, optimizes and characterizes the conjugation of haptens to proteins that can be used for vaccines against drugs of abuse. The effect of hapten density on the ELISA detection of antibodies against haptens demonstrates the importance of careful characterization of the hapten density by the analytical techniques described. C1 [Torres, Oscar B.; Jalah, Rashmi; Alving, Carl R.; Matyas, Gary R.] US Mil HIV Res Program, Lab Adjuvant & Antigen Res, Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Rice, Kenner C.; Li, Fuying; Antoline, Joshua F. G.; Jacobson, Arthur E.] NIDA, US Dept HHS, Drug Design & Synth Sect, Chem Biol Res Branch,NIH, Bethesda, MD 20892 USA. [Rice, Kenner C.; Li, Fuying; Antoline, Joshua F. G.; Iyer, Malliga R.; Jacobson, Arthur E.] NIAAA, NIH, Bethesda, MD 20892 USA. [Torres, Oscar B.; Jalah, Rashmi] US Mil HIV Res Program, Henry M Jackson Fdn Adv Mil Med, Bethesda, MD 20817 USA. [Boutaghou, Mohamed Nazim] Shimadzu Sci Instrument, Columbia, MD 21046 USA. RP Matyas, GR (reprint author), US Mil HIV Res Program, Lab Adjuvant & Antigen Res, Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM gmatyas@hivresearch.org OI Matyas, Gary/0000-0002-2074-2373 FU Henry M. Jackson Foundation for the Advancement of Military Medicine [W81XWH-07-2-067]; US Army Medical Research and Materiel Command (MRMC) [W81XWH-07-2-067]; National Institute on Drug Abuse (NIH) [1DP1DA034787-01]; NIH Intramural Research Programs of the National Institute on Drug Abuse; National Institute of Alcohol Abuse and Alcoholism, NIH, DHHS FX This work was supported through a Cooperative Agreement Award (no. W81XWH-07-2-067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the US Army Medical Research and Materiel Command (MRMC). The work was partially supported by an Avant Garde award to GRM from the National Institute on Drug Abuse (NIH grant no. 1DP1DA034787-01). The work of FL, JFGA, MRI, AEJ, and KCR was supported by the NIH Intramural Research Programs of the National Institute on Drug Abuse and the National Institute of Alcohol Abuse and Alcoholism, NIH, DHHS. NR 39 TC 6 Z9 7 U1 3 U2 37 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1618-2642 EI 1618-2650 J9 ANAL BIOANAL CHEM JI Anal. Bioanal. Chem. PD SEP PY 2014 VL 406 IS 24 BP 5927 EP 5937 DI 10.1007/s00216-014-8035-x PG 11 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA AP1MN UT WOS:000341834500018 PM 25084736 ER PT J AU Lawrence, KL Achee, NL Bernier, UR Mundal, KD Benante, JP AF Lawrence, Kendra L. Achee, Nicole L. Bernier, Ulrich R. Mundal, Kirk D. Benante, John Paul TI Field Evaluations of Topical Arthropod Repellents in North, Central, and South America SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE topical repellent; human volunteer; efficacy; vector-borne disease; biting fly ID EMERGING INFECTIOUS-DISEASES; VECTOR-BORNE DISEASES; MALARIA TRANSMISSION; CLIMATE-CHANGE; CULICIDAE; DEET; MOSQUITOS; DIPTERA; IR3535; VIRUS AB Recently, vector-borne diseases have been resurging in endemic areas and expanding their geographic range into nonendemic areas. Such changes have refocused attention to the potential for major public health events, as naive populations are exposed to these pathogens. Personal topical repellents, recommended by the United States Centers for Disease Control and Prevention and World Health Organization, remain a first line of protection against infection. The current study evaluated the repellent efficacy of four new U.S. Environmental Protection Agency-registered topical repellent products, two with picaridin as the active ingredient and two with IR3535, against a standard DEET (N, N-diethyl-3-methylbenzamide)-based product. All products were evaluated against a wide range of vector species under field conditions across the Americas. Human volunteers were used to evaluate product efficacy as compared with a well-known DEET-based formulation and determine suitability for use by the U.S. military. Findings demonstrated the new formulations performed as well as the standard U.S. military repellent and could be recommended for use. C1 [Lawrence, Kendra L.; Benante, John Paul] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD 20910 USA. [Achee, Nicole L.] Henry M Jackson Fdn, Rockville, MD USA. [Bernier, Ulrich R.] Ctr Med Agr & Vet Entomol, USDA, Agr Res Serv, Gainesville, FL USA. [Mundal, Kirk D.] Naval Med Res Unit 6, Entomol Program, Lima, Peru. RP Benante, JP (reprint author), Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD 20910 USA. EM john.benante@us.army.mil FU Military Infectious Disease Research Program FX We express our appreciation to the volunteers whose cooperation and patience were essential to these repellent evaluations, to Ireneo Briceno and Russell King (Ministry of Health, Belize), and Victor Lopez-Sifuentes and Karin Escobedo-Vargas (NAMRU-6) for their field assistance and coordination, and to Jim Pecor (Walter Reed Biosystematics Unit) for his identification of insect specimens. These evaluations were funded by the Military Infectious Disease Research Program. NR 36 TC 3 Z9 3 U1 2 U2 8 PU ENTOMOLOGICAL SOC AMER PI ANNAPOLIS PA 3 PARK PLACE, STE 307, ANNAPOLIS, MD 21401-3722 USA SN 0022-2585 EI 1938-2928 J9 J MED ENTOMOL JI J. Med. Entomol. PD SEP PY 2014 VL 51 IS 5 BP 980 EP 988 DI 10.1603/ME14075 PG 9 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA AO8ZL UT WOS:000341644600012 PM 25276927 ER PT J AU Shukla, MK Boddu, V Hill, F AF Shukla, Manoj K. Boddu, Veera Hill, Frances TI Computational investigation of interaction of polypyrrole on the surface of single-walled carbon nanotube SO JOURNAL OF MOLECULAR MODELING LA English DT Article DE Electron affinity; Ionization potential; Polypyrrole; Stacking interaction; Zigzag single-walled carbon nanotube ID ELECTROCHEMICAL PROPERTIES; POLYMER NANOCOMPOSITES; CUCUMBER AB A density functional theory investigation of adsorption of monomer, dimer and trimer forms of pyrrole on the outer surface of zigzag (7,0) single-walled carbon nanotube (SWCNT) has been reported. Geometries of the complexes were optimized using the M06-2X functional and the 631G(d,p) basis set. Moreover, 6-311G(d,p), cc-pVDZ and cc-pvrz basis sets were used for the adsorption energy calculation and such energies were corrected for the basis set superposition error, Vertical ionization potential and electron affinity of the investigated system were also computed. The interaction of polypyrrole on the SWCNT surface is characterized by the stacking interaction. Adsorption (binding) energy of pyirole on the SWCNT surface is weak, but such energy increases with the number of monomer units in the pyirole oligomer. In the SWCNT-pyrrole complexes, the oxidation and reduction processes will take place only at the SWCNT The influence of larger unit on the electronic properties of the complex has been detailed. C1 [Shukla, Manoj K.; Hill, Frances] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Boddu, Veera] US Army ERDC CERL, Environm Proc Branch, Installat Div, Champaign, IL 61826 USA. RP Shukla, MK (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Manoj.K.Shukla@usace.army.mil; Veera.Boddu@usace.army.mil NR 33 TC 0 Z9 0 U1 1 U2 15 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1610-2940 EI 0948-5023 J9 J MOL MODEL JI J. Mol. Model. PD SEP PY 2014 VL 20 IS 9 AR 2414 DI 10.1007/s00894-014-2414-2 PG 6 WC Biochemistry & Molecular Biology; Biophysics; Chemistry, Multidisciplinary; Computer Science, Interdisciplinary Applications SC Biochemistry & Molecular Biology; Biophysics; Chemistry; Computer Science GA AP1XJ UT WOS:000341865300017 PM 25129660 ER PT J AU Mhin, S Nittala, K Lee, J Robinson, DS Ihlefeld, JF Brennecka, GL Sanchez, LM Polcawich, RG Jones, JL AF Mhin, Sungwook Nittala, Krishna Lee, Jinhyung Robinson, Douglas S. Ihlefeld, Jon F. Brennecka, Geoff L. Sanchez, Luz M. Polcawich, Ronald G. Jones, Jacob L. TI Phase and Texture Evolution in Chemically Derived PZT Thin Films on Pt Substrates SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Article ID LEAD-ZIRCONATE-TITANATE; CRYSTALLIZATION; TRANSITION; ACTUATORS; PBTIO3; LAYERS; MEMS AB The crystallization of lead zirconate titanate (PZT) thin films was evaluated on two different platinum-coated Si substrates. One substrate consisted of a Pt coating on a Ti adhesion layer, whereas the other consisted of a Pt coating on a TiO2 adhesion layer. The Pt deposited on TiO2 exhibited a higher degree of preferred orientation than the Pt deposited on Ti (as measured by the Full Width at Half Maximum of the 111 peak about the sample normal). PZT thin films with a nominal Zr/Ti ratio of 52/48 were deposited on the substrates using the inverted mixing order (IMO) route. Phase and texture evolution of the thin films were monitored during crystallization using in situ X-ray diffraction at a synchrotron source. The intensity of the Pt3Pb phase indicated that deposition on a highly oriented Pt/TiO2 substrate resulted in less diffusion of Pb into the substrate relative to films deposited on Pt/Ti. There was also no evidence of the pyrochlore phase influencing texture evolution. The results suggest that PZT nucleates directly on Pt, which explains the observation of a more highly oriented 111 texture of PZT on the Pt/TiO2 substrate than on the Pt/Ti substrate. C1 [Mhin, Sungwook; Nittala, Krishna; Lee, Jinhyung] Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. [Robinson, Douglas S.] Argonne Natl Lab, Adv Photon Source, Argonne, IL 60439 USA. [Ihlefeld, Jon F.; Brennecka, Geoff L.] Sandia Natl Labs, Elect Opt & Nano Mat Dept, Albuquerque, NM 87185 USA. [Sanchez, Luz M.; Polcawich, Ronald G.] US Army Res Lab, RF MEMS & Mm Scale Robot, Adelphi, MD 20783 USA. [Jones, Jacob L.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. RP Jones, JL (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. EM Jacobjones@ncsu.edu FU NSF [DMR-1207293]; U.S. Department of the Army [W911NF-09-1-0435]; National Institute for NanoEngineering (NINE) under the Sandia Laboratory Directed Research and Development Program; U.S. Department of Energy's National Nuclear Security Administration [DE-AC04-94AL85000]; U.S. DOE [DE-AC02-06CH11357] FX Portions of this work were supported by the NSF under DMR-1207293, the U.S. Department of the Army under W911NF-09-1-0435, and the National Institute for NanoEngineering (NINE) under the Sandia Laboratory Directed Research and Development Program. Sandia National Laboratories is a multiprogram laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000. Use of the Advanced Photon Source, an Office of Science User Facility operated for the U.S. Department of Energy (DOE) Office of Science by Argonne National Laboratory, was supported by the U.S. DOE under Contract no. DE-AC02-06CH11357. We would like to thank Dr. Jennifer Forrester and Jason Nikkel for their critical review of the manuscript and contributions to figure preparation. The authors would like to thank Dr. Daniel Potrepka and Dr. Joel Martin of the US Army Research Laboratory for their contributions in preparing the Pt/TiO2-coated substrates. NR 26 TC 6 Z9 6 U1 1 U2 28 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-7820 EI 1551-2916 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD SEP PY 2014 VL 97 IS 9 BP 2973 EP 2979 DI 10.1111/jace.13007 PG 7 WC Materials Science, Ceramics SC Materials Science GA AP1JX UT WOS:000341826500042 ER PT J AU Ruhl, DS Cable, BB Martell, DW AF Ruhl, Douglas S. Cable, Benjamin B. Martell, David W. TI Medication Associated with Hearing Loss: 25 Years of Medical Malpractice Cases in the United States SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article DE medication; hearing loss; ototoxicity; medical malpractice ID OTOTOXICITY; CISPLATIN; RISK; ANTIBIOTICS; LITIGATION; SURGERY; OTOLOGY AB Objectives Many medications have the potential for ototoxicity. To potentiate management of this risk, this study examines malpractice litigation trends of lawsuits involving hearing loss associated with medication use. As experts in hearing loss, it may benefit otolaryngologists to be familiar with this information. Study Design Retrospective review. Setting All US civil trials. Subjects and Methods Court records of legal trials from 1987 to 2012 were obtained from 2 major computerized databases. Data were compiled on the demographics of the defendant and plaintiff, use of otolaryngologists as expert witnesses, medication used, legal allegations, verdicts, and judgments. Results Forty-six unique cases met inclusion criteria and were selected for review. Antibiotics (72%), specifically aminoglycosides (47%), were the most common medications cited as causing hearing loss. Eleven (22%) cases were resolved through a settlement before a verdict was reached. Verdicts in favor of the plaintiffs (37%) were awarded an average of $1,134,242. Pediatric patients were more likely to have outcomes in their favor (P = .03) compared to adults. Of the cases found in favor of the plaintiff, the most common reasons cited were inappropriate medication, dose, or duration (59%); failure to properly monitor (39%); and failure to choose a less toxic medication (18%). Conclusions Physicians must be aware of the potential effects of the medications they prescribe. An understanding of potential drug interactions, proper monitoring, and appropriate substitution with less toxic medications are important to improve patient care. Analyzing litigation trends may be used to prevent future lawsuits and improve physician awareness. C1 [Ruhl, Douglas S.; Cable, Benjamin B.; Martell, David W.] Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA. RP Ruhl, DS (reprint author), Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Attn MCHK DSH, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM douglas.s.ruhl.mil@mail.mil NR 31 TC 5 Z9 5 U1 0 U2 4 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0194-5998 EI 1097-6817 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD SEP PY 2014 VL 151 IS 3 BP 431 EP 437 DI 10.1177/0194599814536850 PG 7 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA AP0MU UT WOS:000341757000011 PM 24894421 ER PT J AU Teyhen, DS Aldag, M Edinborough, E Ghannadian, JD Haught, A Kinn, J Kunkler, KJ Levine, B McClain, J Neal, D Stewart, T Thorndike, FP Trabosh, V Wesensten, N Parramore, DJ AF Teyhen, Deydre S. Aldag, Matt Edinborough, Elton Ghannadian, Jason D. Haught, Andrea Kinn, Julie Kunkler, Kevin J. Levine, Betty McClain, James Neal, David Stewart, Tiffany Thorndike, Frances P. Trabosh, Valerie Wesensten, Nancy Parramore, David J. TI Leveraging Technology: Creating and Sustaining Changes for Health SO TELEMEDICINE AND E-HEALTH LA English DT Article DE activity; nutrition; sleep ID WEIGHT-LOSS; PHYSICAL-ACTIVITY; BEHAVIOR-CHANGE; SMOKING CESSATION; EXTRINSIC REWARDS; STEPPED CARE; INTERVENTIONS; SLEEP; HABITS; ACTIGRAPHY AB Objective:The rapid growth and evolution of health-related technology capabilities are driving an established presence in the marketplace and are opening up tremendous potential to minimize and/or mitigate barriers associated with achieving optimal health, performance, and readiness. This article summarizes technology-based strategies that promote healthy habits related to physical activity, nutrition, and sleep.Materials and Methods:The Telemedicine and Advanced Technology Research Center convened a workshop titled Leveraging Technology: Creating & Sustaining Changes for Health (May 29-30, 2013, Fort Detrick, MD). Participants included experts from academia (n=3), government (n=33), and industry (n=16). A modified Delphi method was used to establish expert consensus in six topic areas: (1) physical activity, (2) nutrition, (3) sleep, (4) incentives for behavior change, (5) usability/interoperability, and (6) mobile health/open platform.Results:Overall, 162 technology features, constructs, and best practices were reviewed and prioritized for physical activity monitors (n=29), nutrition monitors (n=35), sleep monitors (n=24), incentives for change (n=36), usability and interoperability (n=25), and open data (n=13).Conclusions:Leading practices, gaps, and research needs for technology-based strategies were identified and prioritized. This information can be used to provide a research and development road map for (1) leveraging technology to minimize barriers to enhancing health and (2) facilitating evidence-based techniques to create and sustain healthy behaviors. C1 [Teyhen, Deydre S.; Edinborough, Elton; Ghannadian, Jason D.; Haught, Andrea; Levine, Betty] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21774 USA. [Aldag, Matt] Booz Allen Hamilton, Rockville, MD USA. [Kinn, Julie] Natl Ctr Telehlth & Technol, Joint Base Lewis McChord, Tacoma, WA USA. [Kunkler, Kevin J.] US Army Med Res & Mat Command, Joint Program Comm, Ft Detrick, MD 21774 USA. [McClain, James] NCI, Bethesda, MD 20892 USA. [Neal, David] Empirica Res, Miami, FL USA. [Stewart, Tiffany] Pennington Biomed Res Ctr, Behav Technol Lab, Baton Rouge, LA 70808 USA. [Thorndike, Frances P.] Univ Virginia Hlth Syst, Dept Psychiat & Neurobehav Sci, Charlottesville, VA USA. [Trabosh, Valerie] US Army Med Res & Mat Command, Mil Operat Med Res Program, Ft Detrick, MD 21774 USA. [Wesensten, Nancy] Walter Reed Army Inst Res, Silver Spring, MD USA. [Parramore, David J.] Army Med, Off Surgeon Gen, Falls Church, VA USA. RP Teyhen, DS (reprint author), US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21774 USA. EM deydre.s.teyhen.mil@mail.mil RI Trivedi, Kruti/E-7558-2015 NR 62 TC 0 Z9 0 U1 1 U2 10 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-5627 EI 1556-3669 J9 TELEMED E-HEALTH JI Telemed. e-Health PD SEP PY 2014 VL 20 IS 9 BP 835 EP 849 DI 10.1089/tmj.2013.0328 PG 15 WC Health Care Sciences & Services SC Health Care Sciences & Services GA AP0OU UT WOS:000341762300009 PM 24978152 ER PT J AU Wolfe, DN Heppner, DG Gardner, SN Jaing, C Dupuy, LC Schmaljohn, CS Canton, K AF Wolfe, Daniel N. Heppner, D. Gray Gardner, Shea N. Jaing, Crystal Dupuy, Lesley C. Schmaljohn, Connie S. Canton, Kevin TI Perspective Piece: Current Strategic Thinking for the Development of a Trivalent Alphavirus Vaccine for Human Use SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID EQUINE-ENCEPHALITIS-VIRUS; EASTERN EQUINE; IN-VIVO; ENCEPHALOMYELITIS VACCINE; NEUTRALIZING ANTIBODIES; EXPERIMENTAL INFECTION; IMMUNE INTERFERENCE; CYNOMOLGUS MACAQUES; ANIMAL-MODELS; MICE AB Vaccinations against the encephalitic alphaviruses (western, eastern, and Venezuelan equine encephalitis virus) are of significant interest to biological defense, public health, and agricultural communities alike. Although vaccines licensed for veterinary applications are used in the Western Hemisphere and attenuated or inactivated viruses have been used under Investigational New Drug status to protect at-risk personnel, there are currently no licensed vaccines for use in humans. Here, we will discuss the need for a trivalent vaccine that can protect humans against all three viruses, recent progress to such a vaccine, and a strategy to continue development to Food and Drug Administration licensure. C1 [Wolfe, Daniel N.; Heppner, D. Gray] Def Threat Reduct Agcy, Chem & Biol Technol Dept, Ft Belvoir, VA 22060 USA. [Heppner, D. Gray] TASC Inc, Lorton, VA USA. [Gardner, Shea N.] Lawrence Livermore Natl Lab, Livermore, CA USA. [Jaing, Crystal] Lawrence Livermore Natl Lab, Phys & Life Sci Directorate, Livermore, CA USA. [Dupuy, Lesley C.; Schmaljohn, Connie S.] US Army Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD USA. Joint Program Execut Off, Joint Vaccine Acquisit Program, Ft Detrick, MD USA. RP Wolfe, DN (reprint author), Def Threat Reduct Agcy, Chem & Biol Technol Dept, 8725 John Kingman Rd, Ft Belvoir, VA 22060 USA. EM daniel.wolfe@dtra.mil; donald.heppner@tasc.com; Gardner26@llnl.gov; jaing2@llnl.gov; lesley.c.dupuy.ctr@mail.mil; connie.s.schmaljohn.civ@mail.mil; kevin.s.carlton.civ@mail.mil NR 52 TC 3 Z9 3 U1 0 U2 6 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD SEP PY 2014 VL 91 IS 3 BP 442 EP 450 DI 10.4269/ajtmh.14-0055 PG 9 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA AO4WQ UT WOS:000341342500004 PM 24842880 ER PT J AU Kuhen, KL Chatterjee, AK Rottmann, M Gagaring, K Borboa, R Buenviaje, J Chen, Z Francek, C Wu, T Nagle, A Barnes, SW Plouffe, D Lee, MCS Fidock, DA Graumans, W van de Vegte-Bolmer, M van Gemert, GJ Wirjanata, G Sebayang, B Marfurt, J Russell, B Suwanarusk, R Price, RN Nosten, F Tungtaeng, A Gettayacamin, M Sattabongkot, J Taylor, J Walker, JR Tully, D Patra, KP Flannery, EL Vinetz, JM Renia, L Sauerwein, RW Winzeler, EA Glynne, RJ Diagana, TT AF Kuhen, Kelli L. Chatterjee, Arnab K. Rottmann, Matthias Gagaring, Kerstin Borboa, Rachel Buenviaje, Jennifer Chen, Zhong Francek, Carolyn Wu, Tao Nagle, Advait Barnes, S. Whitney Plouffe, David Lee, Marcus C. S. Fidock, David A. Graumans, Wouter van de Vegte-Bolmer, Marga van Gemert, Geert J. Wirjanata, Grennady Sebayang, Boni Marfurt, Jutta Russell, Bruce Suwanarusk, Rossarin Price, Ric N. Nosten, Francois Tungtaeng, Anchalee Gettayacamin, Montip Sattabongkot, Jetsumon Taylor, Jennifer Walker, John R. Tully, David Patra, Kailash P. Flannery, Erika L. Vinetz, Joseph M. Renia, Laurent Sauerwein, Robert W. Winzeler, Elizabeth A. Glynne, Richard J. Diagana, Thierry T. TI KAF156 Is an Antimalarial Clinical Candidate with Potential for Use in Prophylaxis, Treatment, and Prevention of Disease Transmission SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID PLASMODIUM LIVER STAGES; HIGH-THROUGHPUT SCREEN; SULFADOXINE-PYRIMETHAMINE; ARTEMISININ RESISTANCE; DRUG DISCOVERY; LIFE-CYCLE; FALCIPARUM; MALARIA; VIVAX; CHLOROQUINE AB Renewed global efforts toward malaria eradication have highlighted the need for novel antimalarial agents with activity against multiple stages of the parasite life cycle. We have previously reported the discovery of a novel class of antimalarial compounds in the imidazolopiperazine series that have activity in the prevention and treatment of blood stage infection in a mouse model of malaria. Consistent with the previously reported activity profile of this series, the clinical candidate KAF156 shows blood schizonticidal activity with 50% inhibitory concentrations of 6 to 17.4 nM against P. falciparum drug-sensitive and drug-resistant strains, as well as potent therapeutic activity in a mouse models of malaria with 50, 90, and 99% effective doses of 0.6, 0.9, and 1.4 mg/kg, respectively. When administered prophylactically in a sporozoite challenge mouse model, KAF156 is completely protective as a single oral dose of 10 mg/kg. Finally, KAF156 displays potent Plasmodium transmission blocking activities both in vitro and in vivo. Collectively, our data suggest that KAF156, currently under evaluation in clinical trials, has the potential to treat, prevent, and block the transmission of malaria. C1 [Kuhen, Kelli L.; Chatterjee, Arnab K.; Gagaring, Kerstin; Borboa, Rachel; Buenviaje, Jennifer; Chen, Zhong; Francek, Carolyn; Wu, Tao; Nagle, Advait; Barnes, S. Whitney; Plouffe, David; Taylor, Jennifer; Walker, John R.; Tully, David; Winzeler, Elizabeth A.; Glynne, Richard J.] Novartis Res Fdn, Genom Inst, San Diego, CA USA. [Rottmann, Matthias] Swiss Trop & Publ Hlth Inst, Basel, Switzerland. [Rottmann, Matthias] Univ Basel, Basel, Switzerland. [Lee, Marcus C. S.; Fidock, David A.] Columbia Univ Coll Phys & Surg, Dept Microbiol & Immunol, New York, NY 10032 USA. [Fidock, David A.] Columbia Univ Coll Phys & Surg, Dept Med, Div Infect Dis, New York, NY 10032 USA. [Graumans, Wouter; van de Vegte-Bolmer, Marga; van Gemert, Geert J.] Radboud Univ Nijmegen, Med Ctr, Dept Med Microbiol, NL-6525 ED Nijmegen, Netherlands. [Wirjanata, Grennady; Marfurt, Jutta; Price, Ric N.] Charles Darwin Univ, Menzies Sch Hlth Res, Global Hlth Div, Darwin, NT 0909, Australia. [Sebayang, Boni] Eijkman Inst Mol Biol, Jakarta, Indonesia. [Russell, Bruce; Suwanarusk, Rossarin; Price, Ric N.] Biopolis, Singapore Immunol Network, Agcy Sci Technol & Res, Lab Malaria Immunobiol, Singapore, Singapore. [Nosten, Francois] Shoklo Malaria Res Unit, Mae Sot, Tak, Thailand. [Nosten, Francois] Mahidol Univ, Fac Trop Med, Bangkok, Thailand. [Nosten, Francois; Renia, Laurent] Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, Oxford, England. [Tungtaeng, Anchalee; Gettayacamin, Montip] Armed Forces Res Inst Med Sci, US Army Med Component, Dept Vet Med, Bangkok 10400, Thailand. [Sattabongkot, Jetsumon] AFRIMS, Dept Entomol, Bangkok, Thailand. [Patra, Kailash P.; Vinetz, Joseph M.] Univ Calif San Diego, Dept Med, Div Infect Dis, La Jolla, CA 92093 USA. [Winzeler, Elizabeth A.] Univ Calif San Diego, Sch Med, Div Pharmacol & Drug Discovery, La Jolla, CA 92093 USA. [Diagana, Thierry T.] Novartis Inst Trop Dis, Singapore, Singapore. RP Diagana, TT (reprint author), Novartis Inst Trop Dis, Singapore, Singapore. EM thierry.diagana@novartis.com RI Russell, Bruce/A-9240-2011; Sauerwein, Robert/C-8519-2013; Suwanarusk, Rossarin/E-2115-2013; Graumans, Wouter/D-9610-2016; OI Price, Richard/0000-0003-2000-2874; Russell, Bruce/0000-0003-2333-4348; Suwanarusk, Rossarin/0000-0002-7310-245X; Nosten, Francois/0000-0002-7951-0745; Vinetz, Joseph/0000-0001-8344-2004 FU Wellcome Trust [WT078285, WT096157]; Medicines for Malaria Venture (MMV); Genomics Institute of the Novartis Research Foundation; Swiss Tropical and Public Health Institute; Novartis Institute for Tropical Diseases; Singapore Immunology Network (SIgN); Horizontal Programme on Infectious Diseases under the Agency for Science, Technology, and Research (A*STAR, Singapore); Shoklo Malaria Research Unit (SMRU); Wellcome Trust of Great Britain; Oxford Tropical Medicine Research Programme of Wellcome Trust-Mahidol University; Wellcome Trust Fellowship [091625] FX We gratefully acknowledge funding and support from the Wellcome Trust (translational research grants WT078285 and WT096157) and the Medicines for Malaria Venture (MMV) to the Genomics Institute of the Novartis Research Foundation, the Swiss Tropical and Public Health Institute, and the Novartis Institute for Tropical Diseases. Funding was also obtained from the Singapore Immunology Network (SIgN) and from the Horizontal Programme on Infectious Diseases under the Agency for Science, Technology, and Research (A*STAR, Singapore). Shoklo Malaria Research Unit (SMRU) is sponsored by The Wellcome Trust of Great Britain, as part of the Oxford Tropical Medicine Research Programme of Wellcome Trust-Mahidol University. The laboratory studies in Papua were funded by MMV and a Wellcome Trust Fellowship awarded to R. N. P. (grant 091625). NR 48 TC 27 Z9 28 U1 1 U2 8 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD SEP PY 2014 VL 58 IS 9 BP 5060 EP 5067 DI 10.1128/AAC.02727-13 PG 8 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA AO3UV UT WOS:000341262700008 PM 24913172 ER PT J AU Reid, SP Shurtleff, AC Costantino, JA Tritsch, SR Retterer, C Spurgers, KB Bavari, S AF Reid, St. Patrick Shurtleff, Amy C. Costantino, Julie A. Tritsch, Sarah R. Retterer, Cary Spurgers, Kevin B. Bavari, Sina TI HSPA5 is an essential host factor for Ebola virus infection SO ANTIVIRAL RESEARCH LA English DT Article DE Ebolavirus; HSPA5; Antiviral ID MOLECULAR CHAPERONE BIP; ENDOPLASMIC-RETICULUM; INTRACELLULAR-TRANSPORT; ER CHAPERONE; G-PROTEIN; GLYCOPROTEINS; IDENTIFICATION; INVOLVEMENT; REGULATOR; INTERACTS AB Development of novel strategies targeting the highly virulent ebolaviruses is urgently required. A proteomic study identified the ER chaperone HSPA5 as an ebolavirus-associated host protein. Here, we show using the FISPA5 inhibitor (-)- epigallocatechin gallate (EGCG) that the chaperone is essential for virus infection, thereby demonstrating a functional significance for the association. Furthermore, in vitro and in vivo gene targeting impaired viral replication and protected animals in a lethal infection model. These findings demonstrate that HSPA5 is vital for replication and can serve as a viable target for the design of host-based countermeasures. Published by Elsevier B.V. C1 [Reid, St. Patrick; Shurtleff, Amy C.; Costantino, Julie A.; Tritsch, Sarah R.; Retterer, Cary; Spurgers, Kevin B.; Bavari, Sina] US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Bavari, S (reprint author), US Army, Med Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA. EM sina.bavari@amedd.army.mil FU Defense Threat Reduction Agency (JSTO-CBD project) [44.10022-08-RD-B]; Defense Threat Reduction Agency (TMTI project) [0048-09-RD-T] FX We thank Sean Van Tongeren for performing mouse infections and Keren Rabinowitz for technical assistance. The research described herein was sponsored by the Defense Threat Reduction Agency (JSTO-CBD project number 44.10022-08-RD-B and TMTI project number 0048-09-RD-T). The opinions, interpretation, conclusions and recommendations in this report are not necessarily endorsed by the U.S. Army. NR 23 TC 15 Z9 17 U1 2 U2 50 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 EI 1872-9096 J9 ANTIVIR RES JI Antiviral Res. PD SEP PY 2014 VL 109 BP 171 EP 174 DI 10.1016/j.antiviral.2014.07.004 PG 4 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA AO6OF UT WOS:000341470700020 PM 25017472 ER PT J AU Gonwong, S Chuenchitra, T Khantapura, P Islam, D Sirisopana, N Mason, CJ AF Gonwong, Siriphan Chuenchitra, Thippawan Khantapura, Patchariya Islam, Dilara Sirisopana, Narongrid Mason, Carl J. TI Pork Consumption and Seroprevalence of Hepatitis E Virus, Thailand, 2007-2008 SO EMERGING INFECTIOUS DISEASES LA English DT Article ID NORTHERN THAILAND; INFECTION; ANTIBODY; PIGS AB The nationwide seroprevalence of hepatitis E IgG was determined among young men in Thailand. Overall seroprevalence was 14% (95% CI 13%-15%); range by province was 3%-26%. Seroprevalence was lowest in the south, an area predominantly occupied by persons of the Islam religion, whose dietary laws proscribe pork. C1 [Gonwong, Siriphan; Chuenchitra, Thippawan; Khantapura, Patchariya; Islam, Dilara; Sirisopana, Narongrid; Mason, Carl J.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Gonwong, S (reprint author), Armed Forces Res Inst Med Sci, Dept Enter Dis, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM siriphang@afrims.org OI MASON, CARL/0000-0002-3676-2811 FU Global Emerging Infections Surveillance and Response System, a division of the Armed Forces Health Surveillance Center, Silver Spring, MD FX This work is supported by the Global Emerging Infections Surveillance and Response System, a division of the Armed Forces Health Surveillance Center, Silver Spring, MD. NR 15 TC 2 Z9 2 U1 0 U2 3 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD SEP PY 2014 VL 20 IS 9 BP 1531 EP 1534 DI 10.3201/eid2009.140418 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AO3JY UT WOS:000341226700015 PM 25148245 ER PT J AU Niu, N Savolainen, J Niu, ZD Jin, MZ Cheng, JRC AF Niu, Nan Savolainen, Juha Niu, Zhendong Jin, Mingzhou Cheng, Jing-Ru C. TI A Systems Approach to Product Line Requirements Reuse SO IEEE SYSTEMS JOURNAL LA English DT Article DE Product line engineering; requirements engineering; reuse in systems engineering; software reuse ID ENTERPRISE ARCHITECTURE; DESIGN; FRAMEWORK; GOALS AB Product line engineering has become the main method for achieving systematic software reuse. Embracing requirements in a product line's asset base enhances the effectiveness of reuse as engineers can work on the abstractions closer to the domain's initial concepts. Conventional proactive approaches to product line engineering cause excessive overhead when codifying the assets. In this paper, we propose a systems-oriented approach to extracting functional requirements profiles. The validated extraction constructs are amenable to semantic case analysis and orthogonal variability modeling, so as to uncover the variation structure and constraints. To evaluate our approach, we present an experiment to quantify the extraction overhead and effectiveness and a case study to assess our approach's usefulness. The results show that our automatic support offers an order-of-magnitude saving over the manual extraction effort without significantly compromising quality and that our approach receives a positive adoption rate by systems engineers. C1 [Niu, Nan] Mississippi State Univ, Dept Comp Sci & Engn, Mississippi State, MS 39762 USA. [Savolainen, Juha] Danfoss Power Elect AS, DK-6300 Grasten, Denmark. [Niu, Zhendong] Beijing Inst Technol, Sch Comp Sci & Technol, Beijing 100081, Peoples R China. [Jin, Mingzhou] Univ Tennessee, Dept Ind & Informat Engn, Knoxville, TN 37996 USA. [Cheng, Jing-Ru C.] US Army Engn Res & Dev Ctr, Informat Technol Lab, Vicksburg, MS 39180 USA. RP Niu, N (reprint author), Mississippi State Univ, Dept Comp Sci & Engn, Mississippi State, MS 39762 USA. EM niu@cse.msstate.edu; JuhaErik.Savolainen@danfoss.com; zniu@bit.edu.cn; jin@utk.edu; ruth.c.cheng@usace.army.mil OI Niu, Nan/0000-0001-5566-2368 FU U.S. Army Engineer Research and Development Center [W912HZ-10-C-0101]; U.S. Department of Transportation [DTOS59-09-G-00058]; U.S. National Science Foundation [CCF-1238336] FX This research is supported in part by the U.S. Army Engineer Research and Development Center under Grant W912HZ-10-C-0101, by the U.S. Department of Transportation under Grant DTOS59-09-G-00058, and by the U.S. National Science Foundation under Grant CCF-1238336. NR 43 TC 5 Z9 5 U1 3 U2 19 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1932-8184 EI 1937-9234 J9 IEEE SYST J JI IEEE Syst. J. PD SEP PY 2014 VL 8 IS 3 BP 827 EP 836 DI 10.1109/JSYST.2013.2260092 PG 10 WC Computer Science, Information Systems; Engineering, Electrical & Electronic; Operations Research & Management Science; Telecommunications SC Computer Science; Engineering; Operations Research & Management Science; Telecommunications GA AO7YC UT WOS:000341567800016 ER PT J AU Niu, N Xu, LD Cheng, JRC Niu, ZD AF Niu, Nan Xu, Li Da Cheng, Jing-Ru C. Niu, Zhendong TI Analysis of Architecturally Significant Requirements for Enterprise Systems SO IEEE SYSTEMS JOURNAL LA English DT Article DE Enterprise systems; requirements engineering; software architecture; systems engineering ID DESIGN; TECHNOLOGY; INTEGRATION; FRAMEWORK; NETWORKS AB In designing and developing enterprise systems, systems engineers must consider the requirements that drive the important architecture decisions. Architecturally significant requirements tend to have a global impact on the underlying software infrastructure, and therefore need to be thoroughly examined. Despite the increasing effort in engineering enterprise systems' requirements, little is known about the analysis of architecture interactions and tradeoffs. In this paper, we propose a framework consisting of an integrated set of activities to help tackle requirements analysis in practice. Specifically, we leverage the quality attribute scenarios to elicit implicit yet significant requirements, to model requirements interplays, to manage terminological interferences, and to determine change impacts. We apply the proposed framework to a customer relationship management software system. The results show that the framework offers concrete insights and can be incorporated into an organization's systems practice with a moderate cost. C1 [Niu, Nan] Mississippi State Univ, Dept Comp Sci & Engn, Mississippi State, MS 39762 USA. [Xu, Li Da] Chinese Acad Sci, Inst Comp Technol, Beijing 100080, Peoples R China. [Xu, Li Da] Old Dominion Univ, Dept Informat Technol & Decis Sci, Norfolk, VA 23529 USA. [Cheng, Jing-Ru C.] US Army Engn Res & Dev Ctr, Informat Technol Lab, Vicksburg, MS 39180 USA. [Niu, Zhendong] Beijing Inst Technol, Sch Comp Sci & Technol, Beijing 100081, Peoples R China. RP Niu, N (reprint author), Mississippi State Univ, Dept Comp Sci & Engn, Mississippi State, MS 39762 USA. EM niu@cse.msstate.edu; lxu@odu.edu; ruth.c.cheng@usace.army.mil; zniu@bit.edu.cn OI Niu, Nan/0000-0001-5566-2368 FU U.S. Army Engineer Research and Development Center Award [W912HZ-10-C-0101]; U.S. National Science Foundation [CCF-1238336, 1044845]; National Natural Science Foundation of China [71132008]; Changjiang Scholar Program of the Ministry of Education of China FX The work of N. Niu was supported by the U.S. Army Engineer Research and Development Center Award W912HZ-10-C-0101 and the U.S. National Science Foundation Award CCF-1238336. The work of L. Da Xu was supported in part by the National Natural Science Foundation of China Award 71132008, the Changjiang Scholar Program of the Ministry of Education of China, and the U.S. National Science Foundation Award 1044845. NR 35 TC 16 Z9 16 U1 0 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1932-8184 EI 1937-9234 J9 IEEE SYST J JI IEEE Syst. J. PD SEP PY 2014 VL 8 IS 3 BP 850 EP 857 DI 10.1109/JSYST.2013.2249892 PG 8 WC Computer Science, Information Systems; Engineering, Electrical & Electronic; Operations Research & Management Science; Telecommunications SC Computer Science; Engineering; Operations Research & Management Science; Telecommunications GA AO7YC UT WOS:000341567800018 ER PT J AU Kopser, J AF Kopser, Joseph TI Accessing Transportation Options with the Swipe of a Screen SO ITE JOURNAL-INSTITUTE OF TRANSPORTATION ENGINEERS LA English DT Editorial Material C1 [Kopser, Joseph] RideScout, Austin, TX 78701 USA. [Kopser, Joseph] US Army, Washington, DC USA. [Kopser, Joseph] Univ Texas Austin, Austin, TX 78712 USA. [Kopser, Joseph] Univ Texas Austin, Strauss Ctr, Austin, TX 78712 USA. [Kopser, Joseph] CleanTX Fdn, Austin, TX USA. RP Kopser, J (reprint author), RideScout, Austin, TX 78701 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INST TRANSPORTATION ENGINEERS PI WASHINGTON PA 1627 EYE STREET, NW, STE 600, WASHINGTON, DC 20006 USA SN 0162-8178 J9 ITE J JI ITE J.-Inst. Transp. Eng. PD SEP PY 2014 VL 84 IS 9 BP 20 EP 21 PG 2 WC Engineering, Civil; Transportation Science & Technology SC Engineering; Transportation GA AO4DM UT WOS:000341286400005 ER PT J AU Cheuvront, SN Kenefick, RW Heavens, KR Spitz, MG AF Cheuvront, Samuel N. Kenefick, Robert W. Heavens, Kristen R. Spitz, Marissa G. TI A Comparison of Whole Blood and Plasma Osmolality and Osmolarity SO JOURNAL OF CLINICAL LABORATORY ANALYSIS LA English DT Article DE calculated osmolarity; measured osmolality; osmol gap; sample volume ID CALCULATING SERUM OSMOLALITY; OSMOLE GAP; WATER; LIMITATIONS; OSMOREGULATION; DEHYDRATION; OSMOMETRY; FORMULAS; GLUCOSE; VALUES AB Background: Substituting whole blood osmolality for plasma osmolality could expedite treatments otherwise delayed by the time required to separate erythrocytes from plasma. The purpose of this study was to compare the measured osmolality (mmol/kg) and calculated osmolarity (mmol/l) of whole blood and plasma. Methods: The osmolality of whole blood and plasma was measured using freezing point depression by micro-osmometer and osmolarity calculated from biosensor measures of sodium, glucose, and blood urea nitrogen. The influence of sample volume was also investigated post hoc by comparing measured osmolality at 20 and 250 mu l. Results: Sixty-two volunteers provided 168 paired whole blood and plasma samples for analysis. The mean difference (whole blood - plasma; +/- standard deviation) in osmolality was 10 +/- 3 mmol/kg. Whole blood was greater than plasma in 168 of 168 cases (100%) and data distributions overlapped by 27%. The mean difference in osmolarity was 0 +/- 2 mmol/l. Whole blood was greater than plasma in 90 of 168 cases (56%) and data distributions overlapped by 90%. The osmol gap (osmolality - osmolarity) was 16 +/- 6 mmol for whole blood and 7 +/- 5 mmol for plasma. Ten volunteers were tested on one occasion post hoc to investigate the potential effects of sample volume. The difference between whole blood and plasma was reduced to 3 +/- 2 mmol/kg with a larger (250 mu l vs. 20 mu l) sample volume. Conclusions: This investigation provides strong evidence that whole blood and plasma osmolality are not interchangeable measurements when a 20 mu l sample is used. (C) 2014 Wiley Periodicals, Inc. C1 [Cheuvront, Samuel N.; Kenefick, Robert W.; Heavens, Kristen R.; Spitz, Marissa G.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. RP Cheuvront, SN (reprint author), US Army, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St,Bldg 42, Natick, MA 01760 USA. EM samuel.n.cheuvront.civ@mail.mil FU United States Army Medical Research and Materiel Command (USAMRMC) FX Grant sponsor: The United States Army Medical Research and Materiel Command (USAMRMC). NR 42 TC 4 Z9 4 U1 4 U2 18 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0887-8013 EI 1098-2825 J9 J CLIN LAB ANAL JI J. Clin. Lab. Anal. PD SEP PY 2014 VL 28 IS 5 BP 368 EP 373 DI 10.1002/jcla.21695 PG 6 WC Medical Laboratory Technology SC Medical Laboratory Technology GA AO8XK UT WOS:000341638900005 PM 24648281 ER PT J AU Ohtake, PJ Childs, JD AF Ohtake, Patricia J. Childs, John D. TI Why Publish Study Protocols? SO PHYSICAL THERAPY LA English DT Editorial Material ID TRIAL PROTOCOLS; REHABILITATION; PEOPLE C1 [Ohtake, Patricia J.] SUNY Buffalo, New York, NY 14260 USA. [Childs, John D.] US Army Baylor Univ, Doctoral Program Phys Therapy, Houston, TX USA. RP Ohtake, PJ (reprint author), SUNY Buffalo, New York, NY 14260 USA. NR 7 TC 1 Z9 1 U1 0 U2 1 PU AMER PHYSICAL THERAPY ASSOC PI ALEXANDRIA PA 1111 N FAIRFAX ST, ALEXANDRIA, VA 22314 USA SN 0031-9023 EI 1538-6724 J9 PHYS THER JI Phys. Ther. PD SEP PY 2014 VL 94 IS 9 BP 1208 EP 1209 DI 10.2522/ptj.2014.94.9.1208 PG 2 WC Orthopedics; Rehabilitation SC Orthopedics; Rehabilitation GA AO3JX UT WOS:000341226600002 PM 25180296 ER PT J AU Jolly, SK DiGiusto, GM AF Jolly, Seth K. DiGiusto, Gerald M. TI Xenophobia and immigrant contact: French public attitudes toward immigration SO SOCIAL SCIENCE JOURNAL LA English DT Article DE European politics; Immigration; Xenophobia; Public opinion ID ANTI-IMMIGRANT; WESTERN-EUROPE; PREJUDICE; OPINION; CONTEXT; THREAT; PREFERENCES; MINORITIES; OPPOSITION; PARTIES AB How does the presence of immigrants in a local community affect xenophobic attitudes? Does contact with immigrants ameliorate or exacerbate anti-immigrant attitudes among citizens? Synthesizing public opinion, economic, and demographic data from France, we test hypotheses concerning the relationship between the presence of immigrant populations and xenophobic sentiments. Supportive of the contact theory, we find that larger immigrant populations decrease xenophobic attitudes. This finding challenges much of the country-level research on immigrant concentration and xenophobia and offers some hope for those who are concerned about the rise of xenophobia and the radical right in the midst of diverse European polities. (C) 2013 Western Social Science Association. Published by Elsevier Inc. All rights reserved. C1 [DiGiusto, Gerald M.] USA, Washington, DC USA. [Jolly, Seth K.] Syracuse Univ, Syracuse, NY 13244 USA. RP Jolly, SK (reprint author), Syracuse Univ, Syracuse, NY 13244 USA. EM skjolly@maxwell.syr.edu; digiusto@gmail.com NR 49 TC 2 Z9 2 U1 16 U2 48 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0362-3319 EI 1873-5355 J9 SOC SCI J JI Soc. Sci. J. PD SEP PY 2014 VL 51 IS 3 BP 464 EP 473 DI 10.1016/j.soscij.2013.09.018 PG 10 WC Social Sciences, Interdisciplinary SC Social Sciences - Other Topics GA AO6RR UT WOS:000341479700015 ER PT J AU Nelson, MS Fam, AZ Busel, JP Bakis, CE Nanni, A Bank, LC Henderson, M Hanus, J AF Nelson, M. S. Fam, A. Z. Busel, J. P. Bakis, C. E. Nanni, A. Bank, L. C. Henderson, M. Hanus, J. TI Fiber-Reinforced Polymer Stay-in-Place Structural Forms for Concrete Bridge Decks: State-of-the-Art Review SO ACI STRUCTURAL JOURNAL LA English DT Review DE bridges; fiber-reinforced polymer (FRP); in-plane restraint; punching shear; slabs; stay-in-place formwork ID FRP; BEHAVIOR; SYSTEM; CONSTRUCTION; DESIGN; PANELS; SLABS AB The state-of-the-art of fiber-reinforced polymer (FRP) composite stay-in-place (SIP) structural form systems for bridge decks is presented in this paper. This technique involves constructing a concrete deck whereby prefabricated FRP components act as both the permanent formwork and the bottom flexural reinforcement. The advantages and limitations of the technology are presented, along with the current progress of experimental and analytical investigations. Extensive laboratory investigation is presented covering numerous aspects of the system, including strength, fatigue, and environmental performance. A variety of system configurations are discussed. Examples of field applications are presented, along with evaluations of cost effectiveness and inspection considerations. The result of these investigations show that FRP SIP formwork systems can be both constructible and meet applicable code requirements for strength and serviceability. Preliminary cost assessments suggest that increases in material costs can be partially offset by savings in labor during installation. Finally, future research needs are identified. C1 [Nelson, M. S.] Queens Univ, Kingston, ON, Canada. [Fam, A. Z.] Queens Univ, Kingston, ON, Canada. [Busel, J. P.] Amer Composite Mfg Assoc, Composites Growth Initiat, Arlington, VA USA. [Bakis, C. E.] Penn State Univ, Dept Engn Sci & Mech, University Pk, PA 16802 USA. [Nanni, A.] Univ Miami, Dept Civil Architectural & Environm Engn, Coral Gables, FL 33124 USA. [Bank, L. C.] CUNY City Coll, Dept Civil Engn, New York, NY 10031 USA. [Henderson, M.] LJB Inc, Lima, OH USA. [Hanus, J.] United States Mil Acad, West Point, NY USA. RP Nelson, MS (reprint author), Queens Univ, Kingston, ON, Canada. RI Fam, Amir/B-4367-2015; Mukhejee, Abhijit/K-5930-2015 OI Mukhejee, Abhijit/0000-0001-6972-8962 NR 42 TC 3 Z9 3 U1 3 U2 35 PU AMER CONCRETE INST PI FARMINGTON HILLS PA 38800 COUNTRY CLUB DR, FARMINGTON HILLS, MI 48331 USA SN 0889-3241 EI 1944-7361 J9 ACI STRUCT J JI ACI Struct. J. PD SEP-OCT PY 2014 VL 111 IS 5 BP 1069 EP 1079 PG 11 WC Construction & Building Technology; Engineering, Civil; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA AO4CW UT WOS:000341284800007 ER PT J AU Lewis, ML AF Lewis, Mary L. TI A Comprehensive Newborn Examination: Part I. General, Head and Neck, Cardiopulmonary SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID CONGENITAL-MALFORMATIONS; RENAL ULTRASONOGRAPHY; EAR ANOMALIES; CRANIOSYNOSTOSIS; DIAGNOSIS; INFANTS; ANKYLOGLOSSIA; MANAGEMENT; DISEASE; PITS AB A comprehensive newborn examination involves a systematic inspection. A Ballard score uses physical and neurologic characteristics to assess gestational age. Craniosynostosis is caused by premature fusion of the sutures, and 20% of children with this condition have a genetic mutation or syndrome. The red reflex assessment is normal if there is symmetry in both eyes, without opacities, white spots, or dark spots. If the red reflex findings are abnormal or the patient has a family history of pertinent eye disorders, consultation with an ophthalmologist is warranted. Newborns with low-set ears should be evaluated for a genetic condition. Renal ultrasonography should be performed only in patients with isolated ear anomalies, such as preauricular pits or cup ears, if they are accompanied by other malformations or significant family history. If ankyloglossia is detected, a frenotomy may be considered if it impacts breastfeeding. The neck should be examined for full range of motion because uncorrected torticollis can lead to plagiocephaly and ear misalignment. Proper auscultation is crucial for evaluation of the bronchopulmonary circulation with close observation for signs of respiratory distress, including tachypnea, nasal flaring, grunting, retractions, and cyanosis. Benign murmurs are often present in the first hours of life. Pulse oximetry should be performed in a systematic fashion before discharge. Copyright (c) 2014 American Academy of Family Physicians. C1 [Lewis, Mary L.] Dwight D Eisenhower Army Med Ctr, Dept Family Med, Ft Gordon, GA 30905 USA. RP Lewis, ML (reprint author), Dwight D Eisenhower Army Med Ctr, 300 E Hosp Rd, Ft Gordon, GA 30905 USA. EM marigoldll@yahoo.com NR 43 TC 1 Z9 1 U1 0 U2 5 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X EI 1532-0650 J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD SEP 1 PY 2014 VL 90 IS 5 BP 289 EP 296 PG 8 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA AO4DH UT WOS:000341285900004 PM 25251088 ER PT J AU Lewis, ML AF Lewis, Mary L. TI A Comprehensive Newborn Examination: Part II. Skin, Trunk, Extremities, Neurologic SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID CIRCUMCISION; MANAGEMENT AB Skin findings are common during the newborn examination. Although these findings are often benign, it is important to visualize the entire skin surface to distinguish these findings and appropriately reassure parents. The chest should be observed for symmetric movement, pectus excavatum, pectus carinatum, prominent xiphoid, or breast tissue. The infant should be as relaxed as possible so that the physician can more easily detect any abdominal masses, which are often renal in origin. A single umbilical artery may be associated with another congenital abnormality, especially renal anomalies, and intrauterine growth restriction and prematurity. Signs of ambiguous genitalia include clitoromegaly and fused labia in girls, and bilateral undescended testes, a micropenis, or a bifid scrotum in boys. Sacral dimples do not warrant further evaluation if they are less than 0.5 cm in diameter, are located within 2.5 cm of the anal verge, and are not associated with cutaneous markers; dimples that do not fit these criteria require ultrasonography to evaluate for spinal dysraphism. Brachial plexus injuries are most common in newborns who are large for gestational age, and physical therapy may be required to achieve normal function. Patients with abnormal findings on Ortolani and Barlow maneuvers should be evaluated further for hip dysplasia. It is also important to assess newborns for tone and confirm the presence of normal primitive reflexes. Copyright (c) 2014 American Academy of Family Physicians. C1 [Lewis, Mary L.] Dwight D Eisenhower Army Med Ctr, Dept Family Med, Ft Gordon, GA 30905 USA. RP Lewis, ML (reprint author), Dwight D Eisenhower Army Med Ctr, 300 E Hosp Rd, Ft Gordon, GA 30905 USA. EM marigoldll@yahoo.com NR 36 TC 1 Z9 1 U1 1 U2 4 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X EI 1532-0650 J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD SEP 1 PY 2014 VL 90 IS 5 BP 297 EP 302 PG 6 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA AO4DH UT WOS:000341285900005 PM 25251089 ER PT J AU Gasier, HG Gaffney-Stomberg, E Young, CR McAdams, DC Lutz, LJ McClung, JP AF Gasier, Heath G. Gaffney-Stomberg, Erin Young, Colin R. McAdams, Douglas C. Lutz, Laura J. McClung, James P. TI The Efficacy of Vitamin D Supplementation During a Prolonged Submarine Patrol SO CALCIFIED TISSUE INTERNATIONAL LA English DT Article DE Bone; Bone turnover; Submergence; Supplementation ID BONE-MINERAL DENSITY; D DEFICIENCY; CARBON-DIOXIDE; PERIPHERAL QCT; CORTICAL BONE; RISK-FACTORS; OBESE WOMEN; METABOLISM; CALCIUM; 25-HYDROXYVITAMIN-D AB Submariners spend prolonged periods submerged without sunlight exposure and may benefit from vitamin D supplementation to maintain vitamin D status. The primary objective of this study was to determine the efficacy of daily vitamin D supplementation on maintenance of 25-hydroxyvitamin D (25(OH)D) during a 3-month submarine patrol. Submariners were randomly divided into three groups: placebo (n = 16), 1,000 IU/day (n = 20), or 2,000 IU/day (n = 17). Anthropometrics, self-reported dietary calcium and vitamin D intake, serum markers of vitamin D and bone metabolism, and peripheral quantitative computed tomography (pQCT) parameters of the tibia were determined before and after the patrol. Prior to departure, 49 % of the subjects were vitamin D insufficient (< 50 nmol/L). Following the patrol, 25(OH)D increased in all groups (p < 0.001): 3.3 +/- A 13.1 (placebo), 4.6 +/- A 11.3 (1,000 IU/day), and 13 +/- A 14 nmol/L (2,000 IU/day). The changes in 25(OH)D levels were dependent upon the baseline concentration of 25(OH)D and body mass (p < 0.001). Osteocalcin increased by 38 % (p < 0.01), and pQCT analyses revealed small, yet significant increases in indices of tibial structure and strength (p < 0.05) that were independent of supplementation. These data suggest that vitamin D status was low prior to the patrol, and the subsequent changes in vitamin D status were dependent on the baseline 25(OH)D levels and body mass. Furthermore, short-term skeletal health does not appear to be negatively affected by 3 months of submergence in spite of a suboptimal response to vitamin D supplementation. C1 [Gasier, Heath G.; Young, Colin R.] Naval Submarine Med Res Lab, Dept Submarine Med & Survival Syst, Groton, CT 06340 USA. [Gaffney-Stomberg, Erin; Lutz, Laura J.; McClung, James P.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA USA. [McAdams, Douglas C.] Submarine Grp Nine, Silverdale, WA USA. RP Gasier, HG (reprint author), Naval Submarine Med Res Lab, Dept Submarine Med & Survival Syst, Groton, CT 06340 USA. EM heath.gasier@dm.duke.edu; erin.g.stomberg.civ@mail.mil; colin.young@med.navy.mil; douglas.c.mcadams.mil@health.mil; laura.j.lutz2.civ@mail.mil; james.p.mcclung8.civ@mail.mil OI Young, Colin/0000-0002-4786-5840 FU Office of Naval Research, Warfighter Performance Department [34, N0001411WX20143] FX We would like to extend our gratitude to the USS Nevada Gold Crew for their participation in this study. In addition, we would like to thank Commander, Submarine Force, Group 9, Squadron 17, and the Naval Branch Health Clinic, Bangor, WA for their permission to conduct this investigation. Additionally, we thank Dr.'s Scott Smith (NASA) and Sue Shapses (Rutgers University) for improving the quality of the research design, and CDR Fred Yeo (NSMRL), LT Joshua Swift (Armed Forces Radiobiological Research Institute), and Dr. Andrew Young (USARIEM) for critically reviewing the manuscript. Finally, we thank Dr. Annely Richardson, Mr. Lee Margolis, Ms. Nancy Murphy, SGT David Gonzalez, SPC Reginald Clyburn, SGT Glen Rossman, HMCM Darrin Way, LCDR Shawn Soutiere, and Dr. Jennifer Rood for their technical assistance. This work was supported by the Office of Naval Research, Warfighter Performance Department (Code 34), Award Number N0001411WX20143. NR 44 TC 2 Z9 2 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0171-967X EI 1432-0827 J9 CALCIFIED TISSUE INT JI Calcif. Tissue Int. PD SEP PY 2014 VL 95 IS 3 BP 229 EP 239 DI 10.1007/s00223-014-9886-z PG 11 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA AN5BE UT WOS:000340603200005 PM 25005834 ER PT J AU Brutsche, KE Wang, P Beck, TM Rosati, JD Legault, KR AF Brutsche, Katherine E. Wang, Ping Beck, Tanya M. Rosati, Julie D. Legault, Kelly R. TI Morphological evolution of a submerged artificial nearshore berm along a low-wave microtidal coast, Fort Myers Beach, west-central Florida, USA SO COASTAL ENGINEERING LA English DT Article DE Nearshore berm nourishment; Equilibrium beach profile; Coastal morphodynamics; Nearshore bar; Nearshore sediment transport; West-central Florida ID MORPHODYNAMICS; PROFILES; BARS; KEY AB Nourishment in the nearshore is becoming an increasingly utilized method for regional sediment management, particularly for dredged material that contains more fine sediment than the native beach. A nearshore berm was constructed at Fort Myers Beach, Florida, USA using mixed-sized sediment dredged from a nearby channel. The nearshore berm, which is the shallowest of its kind, was placed in water depths between 1.2 and 2.4 m with the berm crest just below the mean lower low water level. Based on time-series profiles surveyed from 2009 to 2013, the nearshore berm migrated onshore while the system was approaching a dynamic equilibrium. The distant passage of two tropical storms in the third year generated exceptionally high waves for the study area. Substantial profile change induced by the energetic conditions contributed to rapid evolution of the berm profiles toward equilibrium. Near the end of the fourth year, the berm profiles had returned to the equilibrium shape characteristic of the study area. Gaps in the berm allowed water circulation when the berm became emergent and watercraft access to the beach for recreational purposes. Gaps should be considered as a design parameter for future berm nourishments. Sediment samples collected and analyzed showed that the fine sediment content in the original placed material was selectively transported and deposited offshore, while the coarser component moved onshore. The dry beach maintained the same sediment properties throughout the study period and was not influenced by the fine sediment in the initial construction of the berm. (C) 2014 Elsevier B.V. All rights reserved C1 [Brutsche, Katherine E.; Wang, Ping] Univ S Florida, Sch Geosci, Tampa, FL 33620 USA. [Beck, Tanya M.; Rosati, Julie D.] US Army, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Legault, Kelly R.] US Army Corps Engineers, Coastal Design Sect, Water Resources Engn Branch, Div Engn, Jacksonville, FL 32207 USA. RP Brutsche, KE (reprint author), Univ S Florida, Sch Geosci, 4202 E Fowler Ave,NES 107, Tampa, FL 33620 USA. EM kebrutsche@usf.edu FU U.S. Army Engineer Research and Development Center, Coastal and Hydraulics Laboratory, Coastal Inlets Research Program [W912H2-11-C-0031]; University of South Florida FX This study was funded by the U.S. Army Engineer Research and Development Center, Coastal and Hydraulics Laboratory, Coastal Inlets Research Program (contract number W912H2-11-C-0031), and the University of South Florida. We thank James Lagrone of the USACE Jacksonville District for providing valuable information on the berm construction. The authors are grateful for the field assistance by many students in the Coastal Research Lab at the University of South Florida. Permission was granted by Headquarters, U.S. Army Corps of Engineers, to publish this information. NR 45 TC 5 Z9 5 U1 0 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3839 EI 1872-7379 J9 COAST ENG JI Coast. Eng. PD SEP PY 2014 VL 91 BP 29 EP 44 DI 10.1016/j.coastaleng.2014.04.010 PG 16 WC Engineering, Civil; Engineering, Ocean SC Engineering GA AN8JL UT WOS:000340850300003 ER PT J AU Seay, JF Van Emmerik, REA Hamill, J AF Seay, Joseph F. Van Emmerik, Richard E. A. Hamill, Joseph TI Trunk bend and twist coordination is affected by low back pain status during running SO EUROPEAN JOURNAL OF SPORT SCIENCE LA English DT Article DE Locomotion; continuous relative phase; relative phase variability; multi-plane analysis ID RISK-FACTORS; WALKING; DISORDERS; HISTORY AB Recent literature has related differences in pelvis-trunk coordination to low back pain (LBP) status. In addition, repetitive motions involving bending and twisting have been linked to high incidence of LBP. The purpose of this study was to examine trunk sagittal motion - axial rotation ('bend and twist') coordination during locomotion in three groups of runners classified by LBP status (LBP: current low back pain; RES: resolved low back pain and CTR: control group with no history of LBP). Trunk kinematic data were collected as running speed was systematically increased on a treadmill. Within-segment coordination between trunk sagittal and transverse planes of motion (trunk lean and axial rotation, respectively) was calculated using continuous relative phase (CRP), and coordination variability was defined as the between stride cycle standard deviation of CRP (CRPvar). Bend-twist coordination was more in-phase for the LBP group than CTR (p = 0.010) regardless of running speed. No differences in CRPvar were found between the groups. The results from our coordination (CRP) analysis were sensitive to LBP status and suggest that multi-plane interactions of the trunk should be considered in the assessment of LBP. This analysis also has potential for athletically oriented tasks that involve multi-plane interactions of the trunk, particularly ones that contain asymmetric action, such as sweep rowing or a shot on goal in field hockey or ice hockey. C1 [Seay, Joseph F.; Van Emmerik, Richard E. A.; Hamill, Joseph] Univ Massachusetts, Dept Kinesiol, Amherst, MA 01003 USA. RP Seay, JF (reprint author), US Army Res Inst Environm Med, Mil Performance Div, 15 Kansas St, Natick, MA 01760 USA. EM joseph.seay@us.army.mil FU International Society of Biomechanics Matching Dissertation Grant FX This research was funded in part by an International Society of Biomechanics Matching Dissertation Grant awarded to Joseph Seay. NR 19 TC 3 Z9 3 U1 0 U2 4 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1746-1391 EI 1536-7290 J9 EUR J SPORT SCI JI Eur. J. Sport Sci. PD SEP PY 2014 VL 14 IS 6 BP 563 EP 568 DI 10.1080/17461391.2013.866167 PG 6 WC Sport Sciences SC Sport Sciences GA AO0TS UT WOS:000341025900007 PM 24313829 ER PT J AU Rovira, E Cross, A Leitch, E Bonaceto, C AF Rovira, Ericka Cross, Austin Leitch, Evan Bonaceto, Craig TI Displaying Contextual Information Reduces the Costs of Imperfect Decision Automation in Rapid Retasking of ISR Assets SO HUMAN FACTORS LA English DT Article DE automation reliability; human-automation interaction; ISR assets; contextual information; automation imperfection ID SUPERVISORY CONTROL; TRUST; WORKLOAD; VEHICLES; CAPACITY; RELIANCE; MISUSE; IMPACT; AIDS AB Objective: The impact of a decision support tool designed to embed contextual mission factors was investigated. Contextual information may enable operators to infer the appropriateness of data underlying the automation's algorithm. Background: Research has shown the costs of imperfect automation are more detrimental than perfectly reliable automation when operators are provided with decision support tools. Operators may trust and rely on the automation more appropriately if they understand the automation's algorithm. The need to develop decision support tools that are understandable to the operator provides the rationale for the current experiment. Method: A total of 17 participants performed a simulated rapid retasking of intelligence, surveillance, and reconnaissance (ISR) assets task with manual, decision automation, or contextual decision automation differing in two levels of task demand: low or high. Automation reliability was set at 80%, resulting in participants experiencing a mixture of reliable and automation failure trials. Dependent variables included ISR coverage and response time of replanning routes. Results: Reliable automation significantly improved ISR coverage when compared with manual performance. Although performance suffered under imperfect automation, contextual decision automation helped to reduce some of the decrements in performance. Conclusion: Contextual information helps overcome the costs of imperfect decision automation. Application: Designers may mitigate some of the performance decrements experienced with imperfect automation by providing operators with interfaces that display contextual information, that is, the state of factors that affect the reliability of the automation's recommendation. C1 [Rovira, Ericka; Cross, Austin; Leitch, Evan] US Mil Acad, West Point, NY 10996 USA. [Bonaceto, Craig] MITRE, Command & Control Ctr, Bedford, MA USA. RP Rovira, E (reprint author), US Mil Acad, 267 Thayer Hall Engn Psychol, West Point, NY 10996 USA. EM Ericka.Rovira@usma.edu FU MITRE Corporation [36] FX This work was supported by Grant 36 from the MITRE Corporation. The views expressed in this work are those of the authors and do not necessarily reflect official U. S. Army or MITRE policy. NR 40 TC 1 Z9 1 U1 1 U2 14 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0018-7208 EI 1547-8181 J9 HUM FACTORS JI Hum. Factors PD SEP PY 2014 VL 56 IS 6 BP 1036 EP 1049 DI 10.1177/0018720813519675 PG 14 WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Behavioral Sciences; Engineering; Psychology GA AN8BT UT WOS:000340827100002 PM 25277015 ER PT J AU Lieberman, HR Karl, JP Niro, PJ Williams, KW Farina, EK Cable, SJ McClung, JP AF Lieberman, Harris R. Karl, J. Philip Niro, Philip J. Williams, Kelly W. Farina, Emily K. Cable, Sonya J. McClung, James P. TI Positive Effects of Basic Training on Cognitive Performance and Mood of Adult Females SO HUMAN FACTORS LA English DT Article DE army; stress fatigue; depression; reaction time; vigilance; learning; boot camp; structured training; soldiers ID PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; IRON STATUS; WORKING-MEMORY; OLDER-ADULTS; SLEEP LOSS; SOLDIERS; DECREMENTS; CAFFEINE; STRESS AB Objective: This study investigated whether a stressful military training program, the 9- to 10-week U. S. Army basic combat training (BCT) course, alters the cognitive performance and mood of healthy young adult females. Background: Structured training programs including adolescent boot camps, sports training camps, learning enrichment programs, and military basic training are accepted methods for improving academic and social functioning. However, limited research is available on the behavioral effects of structured training programs in regard to cognitive performance and mood. Method: Two separate, within-subject studies were conducted with different BCT classes; in total 212 female volunteers were assessed before and after BCT. In Study 1, Four-Choice Reaction Time, Match-to-Sample, and Grammatical Reasoning tests were administered. The Psychomotor Vigilance Test (PVT) was administered in Study 2. The Profile of Mood States (POMS) was administered in both studies. Results: In Study 1, reaction time to correct responses on all three of the performance tests improved from pre- to post-BCT. In Study 2, PVT reaction time significantly improved. All POMS subscales improved over time in the second study, whereas POMS subscales in the first study failed to meet criteria for statistically significant differences over time. Conclusion: Cognition and mood substantially improved over military basic training. These changes may be a result of structured physical and mental training experienced during basic training or other factors not as yet identified. Application: Properly structured training may have extensive, beneficial effects on cognitive performance and mood; however, additional research is needed to determine what factors are responsible for such changes. C1 [Lieberman, Harris R.; Niro, Philip J.; McClung, James P.] US Army, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. [Karl, J. Philip] US Army, Environm Med Res Inst, Natick, MA 01760 USA. [Williams, Kelly W.; Farina, Emily K.] Oak Ridge Associated Univ, Oak Ridge, TN USA. [Cable, Sonya J.] Initial Mil Training Ctr Excellence, Human Dimens Div, Ft Eustis, VA USA. RP Lieberman, HR (reprint author), US Army, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. EM harris.lieberman@us.army.mil OI Karl, J. Philip/0000-0002-5871-2241 FU Military Operational Medicine Research Program of the U.S. Army Medical Research and Materiel Command FX The authors wish to acknowledge the soldier volunteers that participated in the present study as well as the command staff at Fort Jackson, South Carolina, for allowing access to the soldiers. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U. S. Army or Department of Defense. Human subjects participated in these studies after giving their free and informed voluntary consent. The investigators have adhered to the policies for protection of human subjects as prescribed in Army Regulation 70-25, and the research was conducted in adherence with the provisions of 32 CFR Part 219. Citations of commercial organizations and trade names in this report do not constitute an official U. S. Department of the Army endorsement or approval of the products or services of these organizations. None of the authors had a personal or financial conflict of interest. This research was supported by the Military Operational Medicine Research Program of the U.S. Army Medical Research and Materiel Command. NR 39 TC 4 Z9 4 U1 2 U2 32 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0018-7208 EI 1547-8181 J9 HUM FACTORS JI Hum. Factors PD SEP PY 2014 VL 56 IS 6 BP 1113 EP 1123 DI 10.1177/0018720813519472 PG 11 WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Behavioral Sciences; Engineering; Psychology GA AN8BT UT WOS:000340827100007 PM 25277020 ER PT J AU Ananworanich, J Avihingsanon, A AF Ananworanich, Jintanat Avihingsanon, Anchalee TI HIV and Noncommunicable Diseases: The Asian Perspective SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE HIV; Asia; noncommunicable diseases; HIV-associated neurocognitive disorders; non-Hodgkin lymphoma; kidney disease ID HUMAN-IMMUNODEFICIENCY-VIRUS; HEPATITIS-B-VIRUS; MIDDLE-INCOME COUNTRIES; CHRONIC KIDNEY-DISEASE; BONE-MINERAL DENSITY; RISK-FACTORS; ANTIRETROVIRAL THERAPY; INFECTED PATIENTS; NEUROCOGNITIVE DISORDERS; HIV-1-INFECTED PATIENTS AB Asia is seeing a rise in noncommunicable diseases in their general population and among people living with HIV. Many Asians have low body weight, which can lead to higher plasma concentrations of antiretrovirals and, as a result, their toxicities. Examples are metabolic complications from protease inhibitors, chronic kidney disease from tenofovir, and hepatotoxicity from nevirapine. Asia has not only the highest burden of hepatitis B viral infection than any other continent but also a predominance of genotypes B and C, the latter associated with higher risk for hepatocellular carcinoma. HIV-associated neurocognitive disorders are equally common among Asians as other populations. Diastolic dysfunction and asymptomatic myocardial ischemia are not infrequent. Non-Hodgkin lymphoma is the most common AIDS-related cancer, whereas Kaposi sarcoma is relatively infrequent. Emerging data show high prevalence of human papillomavirus-associated anal dysplasia in men who have sex with men. Resource-limited countries in Asia suffer from lack of resources for national screening programs of noncommunicable diseases, which, in turn, limits the epidemiologic data that exist to guide the use of national health resources. C1 [Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Avihingsanon, Anchalee] Thai Red Cross AIDS Res Ctr, HIV NAT, Bangkok, Thailand. [Avihingsanon, Anchalee] Chulalongkorn Univ, Fac Med, Dept Med, Div Allergy & Immunol, Bangkok 10330, Thailand. RP Ananworanich, J (reprint author), Mil HIV Res Program, 6720A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA. EM jananworanich@hivresearch.org NR 85 TC 4 Z9 4 U1 2 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD SEP 1 PY 2014 VL 67 SU 1 BP S99 EP S103 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AO1PT UT WOS:000341086200012 PM 25117967 ER PT J AU Li, SYS Gilbert, PB Tomaras, GD Kijak, G Ferrari, G Thomas, R Pyo, CW Zolla-Pazner, S Montefiori, D Liao, HX Nabel, G Pinter, A Evans, DT Gottardo, R Dal, JY Janes, H Morris, D Fong, YY Edlefsen, PT Li, FS Frahm, N Alpert, MD Prentice, H Rerks-Ngarm, S Pitisuttithum, P Kaewkungwal, J Nitayaphan, S Robb, ML O'Connell, RJ Haynes, BF Michael, NL Kim, JH McElrath, MJ Geraghty, DE AF Li, Shuying S. Gilbert, Peter B. Tomaras, Georgia D. Kijak, Gustavo Ferrari, Guido Thomas, Rasmi Pyo, Chul-Woo Zolla-Pazner, Susan Montefiori, David Liao, Hua-Xin Nabel, Gary Pinter, Abraham Evans, David T. Gottardo, Raphael Dal, James Y. Janes, Holly Morris, Daryl Fong, Youyi Edlefsen, Paul T. Li, Fusheng Frahm, Nicole Alpert, Michael D. Prentice, Heather Rerks-Ngarm, Supachai Pitisuttithum, Punnee Kaewkungwal, Jaranit Nitayaphan, Sorachai Robb, Merlin L. O'Connell, Robert J. Haynes, Barton F. Michael, Nelson L. Kim, Jerome H. McElrath, M. Juliana Geraghty, Daniel E. TI FCGR2C polymorphisms associate with HIV-1 vaccine protection in RV144 trial SO JOURNAL OF CLINICAL INVESTIGATION LA English DT Article ID FC-GAMMA RECEPTORS; EFFICACY TRIAL; GENETIC-VARIATION; IMMUNE-RESPONSES; RANDOMIZED-TRIAL; HOST GENETICS; RIIC GENE; INFECTION; ANTIBODIES; CELLS AB The phase III RV144 HIV-1 vaccine trial estimated vaccine efficacy (VE) to be 31.2%. This trial demonstrated that the presence of HIV-1-specific IgG-binding Abs to envelope (Env) V1V2 inversely correlated with infection risk, while the presence of Env-specific plasma IgA Abs directly correlated with risk of HIV-1 infection. Moreover, Ab-dependent cellular cytotoxicity responses inversely correlated with risk of infection in vaccine recipients with low IgA; therefore, we hypothesized that vaccine-induced Fc receptor-mediated (FcR-mediated) Ab function is indicative of vaccine protection. We sequenced exons and surrounding areas of FcR-encoding genes and found one FCGR2C tag SNP (rs114945036) that associated with VE against HIV-1 subtype CRF01_AE, with lysine at position 169 (169K) in the V2 loop (CRF01_AE 169K). Individuals carrying CC in this SNP had an estimated VE of 15%, while individuals carrying CT or TT exhibited a VE of 91%. Furthermore, the rs114945036 SNP was highly associated with 3 other FCGR2C SNPs (rs138747765, rs78603008, and rs373013207). Env-specific IgG and IgG3 Abs, IgG avidity, and neutralizing Abs inversely correlated with CRF01_AE 169K HIV-1 infection risk in the CT- or TT-carrying vaccine recipients only. These data suggest a potent role of Fc-gamma receptors and Fc-mediated Ab function in conferring protection from transmission risk in the RV144 VE trial. C1 [Li, Shuying S.; Gilbert, Peter B.; Gottardo, Raphael; Dal, James Y.; Janes, Holly; Morris, Daryl; Fong, Youyi; Edlefsen, Paul T.; Li, Fusheng] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Stat Ctr HIV AIDS Res & Prevent, Seattle, WA 98109 USA. [Tomaras, Georgia D.; Ferrari, Guido; Montefiori, David; Liao, Hua-Xin; Haynes, Barton F.] Duke Univ, Sch Med, Duke Univ Human Vaccine Inst, Durham, NC USA. [Kijak, Gustavo; Thomas, Rasmi; Prentice, Heather; Robb, Merlin L.; O'Connell, Robert J.; Michael, Nelson L.; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil Res Program, Silver Spring, MD USA. [Pyo, Chul-Woo; Geraghty, Daniel E.] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98109 USA. [Zolla-Pazner, Susan] Vet Affairs New York Harbor Healthcare Syst, New York, NY USA. [Zolla-Pazner, Susan] NYU, Sch Med, Dept Pathol, New York, NY USA. [Nabel, Gary] Sanofi, Global R&D, Cambridge, MA USA. [Pinter, Abraham] State Univ New Jersey, New Jersey Med Sch, Publ Hlth Res Inst Ctr, Newark, NJ USA. [Evans, David T.] Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI USA. [Frahm, Nicole; McElrath, M. Juliana] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98109 USA. [Alpert, Michael D.] Harvard Univ, New England Reg Primate Res Ctr, Sch Med, Dept Microbiol & Immunobiol, Southborough, MA 01772 USA. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand. [Pitisuttithum, Punnee; Kaewkungwal, Jaranit] Mahidol Univ, Fac Trop Med, Bangkok, Thailand. [Nitayaphan, Sorachai] Armed Forces Res Inst Med Sci, Royal Thai Army, Bangkok 10400, Thailand. RP Li, SYS (reprint author), Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, 1100 Fairview Ave N,POB 19024 M2-C200, Seattle, WA 98109 USA. EM sli@fhcrc.org; pgilbert@scharp.org RI Ferrari, Guido/A-6088-2015; Tomaras, Georgia/J-5041-2016 FU US Army Medical Research and Material Command [Y1-AI-2642-12]; NIAID [Y1-AI-2642-12]; Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. [W81XWH-07-2-0067]; US Department of Defense [W81XWH-07-2-0067]; NIH/NIAID [AI067854, UM1AI-068618, R37AI054165]; National Heart, Lung, and Blood Institute [R01 HL114901] FX The authors thank David Goldstein and Mary Carrington for their reviews and advice; Charla Andrews from the US Military HIV Research Program for coordination; Nicole L. Yates, S. Munir Alam, and Xiaoying Shen for data contributions; and the RV144 study volunteers. This study was supported in part by an Interagency Agreement (Y1-AI-2642-12) between the US Army Medical Research and Material Command and NIAID. This work was also supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. and the US Department of Defense; by a U01 grant from NIH/NIAID, AI067854 (the Center for HIV/AIDS Vaccine Immunology); by NIH/NIAID grant UM1AI-068618 (HVTN Laboratory Program); and by NIH/NIAID grant R37AI054165 and National Heart, Lung, and Blood Institute grant R01 HL114901. The opinions herein are those of the authors and should not be construed as official or representing the views of the US Department of Health and Human Services, NIAID, the Department of Defense, or Department of the Army. NR 53 TC 26 Z9 26 U1 1 U2 6 PU AMER SOC CLINICAL INVESTIGATION INC PI ANN ARBOR PA 35 RESEARCH DR, STE 300, ANN ARBOR, MI 48103 USA SN 0021-9738 EI 1558-8238 J9 J CLIN INVEST JI J. Clin. Invest. PD SEP PY 2014 VL 124 IS 9 BP 3879 EP 3890 DI 10.1172/JCI75539 PG 12 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA AO2PQ UT WOS:000341168100023 PM 25105367 ER PT J AU Chaudhury, S Reifman, J Wallqvist, A AF Chaudhury, Sidhartha Reifman, Jaques Wallqvist, Anders TI Simulation of B Cell Affinity Maturation Explains Enhanced Antibody Cross-Reactivity Induced by the Polyvalent Malaria Vaccine AMA1 SO JOURNAL OF IMMUNOLOGY LA English DT Article ID APICAL MEMBRANE ANTIGEN-1; HUMORAL IMMUNE-RESPONSE; A VIRUS-INFECTION; MATHEMATICAL-MODEL; CLONAL SELECTION; DENGUE VIRUS; INHIBITORY ANTIBODY; SOMATIC MUTATION; MEMORY; ESCAPE AB Polyvalent vaccines use a mixture of Ags representing distinct pathogen strains to induce an immune response that is cross-reactive and protective. However, such approaches often have mixed results, and it is unclear how polyvalency alters the fine specificity of the Ab response and what those consequences might be for protection. In this article, we present a coarse-grain theoretical model of B cell affinity maturation during monovalent and polyvalent vaccinations that predicts the fine specificity and cross-reactivity of the Ab response. We stochastically simulate affinity maturation using a population dynamics approach in which the host B cell repertoire is represented explicitly, and individual B cell subpopulations undergo rounds of stimulation, mutation, and differentiation. Ags contain multiple epitopes and are present in subpopulations of distinct pathogen strains, each with varying degrees of cross-reactivity at the epitope level. This epitope- and strain-specific model of affinity maturation enables us to study the composition of the polyclonal response in granular detail and identify the mechanisms driving serum specificity and cross-reactivity. We applied this approach to predict the Ab response to a polyvalent vaccine based on the highly polymorphic malaria Ag apical membrane antigen-1. Our simulations show how polyvalent apical membrane Ag-1 vaccination alters the selection pressure during affinity maturation to favor cross-reactive B cells to both conserved and strain-specific epitopes and demonstrate how a polyvalent vaccine with a small number of strains and only moderate allelic coverage may be broadly neutralizing. Our findings suggest that altered fine specificity and enhanced cross-reactivity may be a universal feature of polyvalent vaccines. C1 [Chaudhury, Sidhartha; Reifman, Jaques; Wallqvist, Anders] US Dept Def, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, US Army Med Res & Mat Command, Frederick, MD 21702 USA. RP Chaudhury, S (reprint author), US Dept Def, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, US Army Med Res & Mat Command,Attent MCMR TT, 504 Scott St, Frederick, MD 21702 USA. EM schaudhury@bhsai.org OI wallqvist, anders/0000-0002-9775-7469 FU U.S. Army's Network Science Initiative; U.S. Army Military Infectious Disease Research Program; U.S. Army Medical Research and Materiel Command FX This work was supported by the U.S. Army's Network Science Initiative, the U.S. Army Military Infectious Disease Research Program, and the U.S. Army Medical Research and Materiel Command (Ft. Detrick, MD). NR 73 TC 14 Z9 14 U1 1 U2 10 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 EI 1550-6606 J9 J IMMUNOL JI J. Immunol. PD SEP 1 PY 2014 VL 193 IS 5 BP 2073 EP 2086 DI 10.4049/jimmunol.1401054 PG 14 WC Immunology SC Immunology GA AO2HT UT WOS:000341140600010 PM 25080483 ER PT J AU Grujicic, M Snipes, JS Galgalikar, R Ramaswami, S Yavari, R Yen, CF Cheeseman, BA AF Grujicic, M. Snipes, J. S. Galgalikar, R. Ramaswami, S. Yavari, R. Yen, C. -F. Cheeseman, B. A. TI Ballistic-Failure Mechanisms in Gas Metal Arc Welds of Mil A46100 Armor-Grade Steel: A Computational Investigation SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE LA English DT Article DE ballistic limit; gas metal arc welding (GMAW) process modeling; welded all-metal ID AA5083-H116 ALUMINUM PLATES; MICROSTRUCTURE EVOLUTION; PROJECTILES; PERFORATION AB In our recent work, a multi-physics computational model for the conventional gas metal arc welding (GMAW) joining process was introduced. The model is of a modular type and comprises five modules, each designed to handle a specific aspect of the GMAW process, i.e.: (i) electro-dynamics of the welding-gun; (ii) radiation-/convection-controlled heat transfer from the electric-arc to the workpiece and mass transfer from the filler-metal consumable electrode to the weld; (iii) prediction of the temporal evolution and the spatial distribution of thermal and mechanical fields within the weld region during the GMAW joining process; (iv) the resulting temporal evolution and spatial distribution of the material microstructure throughout the weld region; and (v) spatial distribution of the as-welded material mechanical properties. In the present work, the GMAW process model has been upgraded with respect to its predictive capabilities regarding the spatial distribution of the mechanical properties controlling the ballistic-limit (i.e., penetration-resistance) of the weld. The model is upgraded through the introduction of the sixth module in the present work in recognition of the fact that in thick steel GMAW weldments, the overall ballistic performance of the armor may become controlled by the (often inferior) ballistic limits of its weld (fusion and heat-affected) zones. To demonstrate the utility of the upgraded GMAW process model, it is next applied to the case of butt-welding of a prototypical high-hardness armor-grade martensitic steel, MIL A46100. The model predictions concerning the spatial distribution of the material microstructure and ballistic-limit-controlling mechanical properties within the MIL A46100 butt-weld are found to be consistent with prior observations and general expectations. C1 [Grujicic, M.; Snipes, J. S.; Galgalikar, R.; Ramaswami, S.; Yavari, R.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. [Yen, C. -F.; Cheeseman, B. A.] Army Res Lab, Survivabil Mat Branch, Aberdeen, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM gmica@clemson.edu FU Army Research Office [W911NF-11-1-0207, W911NF-11-1-0518] FX The material presented in this paper is based on work supported by two Army Research Office sponsored grants entitled "riction Stir Welding Behavior of Selected 2000-series and 5000-series Aluminum Alloys" (Contract Number W911NF-11-1-0207), and "oncept Validation and Optimization for a Vent-based Mine-blast Mitigation System" (Contract Number W911NF-11-1-0518). The authors are indebted to Dr. Ralph A. Anthenien, Jr. and Dr. Bryan Glaz of ARO for their continuing support and interest in the present NR 39 TC 10 Z9 10 U1 0 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9495 EI 1544-1024 J9 J MATER ENG PERFORM JI J. Mater. Eng. Perform. PD SEP PY 2014 VL 23 IS 9 BP 3108 EP 3125 DI 10.1007/s11665-014-1090-9 PG 18 WC Materials Science, Multidisciplinary SC Materials Science GA AO1QV UT WOS:000341089200005 ER PT J AU Sheean, AJ Krueger, CA Napierala, MA Stinner, DJ Hsu, JR AF Sheean, Andrew J. Krueger, Chad A. Napierala, Matthew A. Stinner, Daniel J. Hsu, Joseph R. CA Skeletal Trauma Res Consortium STR TI Evaluation of the Mangled Extremity Severity Score in Combat-Related Type III Open Tibia Fracture SO JOURNAL OF ORTHOPAEDIC TRAUMA LA English DT Article DE MESS; type III open tibia; outcomes ID OPERATION ENDURING FREEDOM; IRAQI FREEDOM; AMPUTATION; INJURIES; WOUNDS AB Objectives: The purpose of this study was to determine the extent to which the Mangled Extremity Severity Score (MESS) predicted outcomes for soldiers sustaining combat-related Gustilo-Anderson type III open tibia fractures. Design: Retrospective cohort study. Setting: Tertiary trauma center. Patients: Service Members with combat-related type III open tibia fractures occurring between 2003 and 2007 treated definitively in a US military medical center. Intervention: Amputation or limb salvage. Main Outcome Measurements: MESS, amputation or limb salvage. Results: Complete data were available for 155 patients treated for type III open tibia fractures. One hundred ten patients had salvaged limbs, and 45 patients had lower extremity amputations. The mean MESS values for amputees and patients treated with limb salvage were 5.8 and 5.3 (P = 0.057), respectively. The sensitivity and specificity of a MESS >= 7 predicting amputation was 35% and 87.8%, respectively. A MESS value of >= 7 was found to have a positive predictive value on 50%. Thirty-three percent of patients treated with amputation had an associated vascular injury versus 12.7% of patients treated with limb salvage (P < 0.0026). Conclusions: There was no significant difference between MESS values of amputees and those treated with limb salvage. Moreover, these data demonstrate that the MESS is neither sensitive nor accurate in predicting amputation. C1 [Sheean, Andrew J.; Krueger, Chad A.; Napierala, Matthew A.; Stinner, Daniel J.] Brooke Army Med Ctr, San Antonio Mil Med Ctr, Dept Orthopaed Surg, Ft Sam Houston, TX 78234 USA. [Hsu, Joseph R.] Carolinas Med Ctr, Dept Orthopaed Surg, Charlotte, NC 28203 USA. RP Sheean, AJ (reprint author), Brooke Army Med Ctr, San Antonio Mil Med Ctr, Dept Orthopaed Surg, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Andrew.j.sheean.mil@mail.mil NR 11 TC 4 Z9 4 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0890-5339 EI 1531-2291 J9 J ORTHOP TRAUMA JI J. Orthop. Trauma PD SEP PY 2014 VL 28 IS 9 BP 523 EP 526 PG 4 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA AO0TU UT WOS:000341026100013 PM 24378400 ER PT J AU Cook, JB Knox, JB Wimberly, RL Ellis, HB Riccio, AI AF Cook, Jay B. Knox, Jeffrey B. Wimberly, Robert L. Ellis, Henry B. Riccio, Anthony I. TI "Fight-Bite": Not Just a Hand Problem SO JOURNAL OF PEDIATRIC ORTHOPAEDICS LA English DT Article DE knee; infection; septic arthritis; bite; children ID ARTHRITIS; WOUNDS AB Human bite wounds around the knee are rarely seen, yet may require the same urgent attention as a fight bite to the hand. Two cases of polymicrobial septic arthritis of the knee secondary to a human bite wound are described. In both the cases, the diagnosis of the septic arthritis was delayed because the intra-articular wound was unrecognized. The injuries were initially deemed superficial and managed with local wound care. In each case, the knee was flexed at the time of injury and the quadriceps tendon was penetrated by a tooth which inoculated the knee joint. Septic arthritis of the knee presented, in both cases, 72 hours after the injury. These infections proved challenging to treat and required multiple surgeries and prolonged antibiotic therapy. The "fight bite" phenomenon of the hand is widely recognized and the same phenomenon can occur at the knee. C1 [Cook, Jay B.; Knox, Jeffrey B.] Tripler Army Med Ctr, Orthoped Surg Serv, Honolulu, HI 96859 USA. [Wimberly, Robert L.; Ellis, Henry B.; Riccio, Anthony I.] Texas Scottish Rite Hosp Children, Dept Orthoped, Dallas, TX 75219 USA. [Wimberly, Robert L.; Ellis, Henry B.; Riccio, Anthony I.] Childrens Med Ctr, Dallas, TX 75219 USA. RP Riccio, AI (reprint author), Texas Scottish Rite Hosp Children, Dept Orthopaed Surg, 2222 Welborn St, Dallas, TX 75219 USA. EM anthony.riccio@childrens.com NR 11 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0271-6798 EI 1539-2570 J9 J PEDIATR ORTHOPED JI J. Pediatr. Orthop. PD SEP PY 2014 VL 34 IS 6 BP 647 EP 649 PG 3 WC Orthopedics; Pediatrics SC Orthopedics; Pediatrics GA AO2HP UT WOS:000341140000020 ER PT J AU Akers, KS Niece, KL Chung, KK Cannon, JW Cota, JM Murray, CK AF Akers, Kevin S. Niece, Krista L. Chung, Kevin K. Cannon, Jeremy W. Cota, Jason M. Murray, Clinton K. TI Modified Augmented Renal Clearance score predicts rapid piperacillin and tazobactam clearance in critically ill surgery and trauma patients SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Augmented Renal Clearance; ARC score; sensitivity and specificity; antimicrobial pharmacokinetics and pharmacodynamics; trauma critical care ID CONTINUOUS-INFUSION; SEVERE SEPSIS; SEPTIC SHOCK; PHARMACOKINETICS AB BACKGROUND: Recent evidence suggests that current antimicrobial dosing may be inadequate for some critically ill patients. A major contributor in patients with unimpaired renal function may be Augmented Renal Clearance (ARC), wherein urinary creatinine clearance exceeds that predicted by serum creatinine concentration. We used pharmacokinetic data to evaluate the diagnostic accuracy of a recently proposed ARC score. METHODS: Pharmacokinetic data from trauma/surgical intensive care unit patients receiving piperacillin/tazobactam were evaluated. We combined intermediate scores (4-6 points) into a single low score (<= 6) group and compared pharmacokinetic parameters against the high (>= 7) ARC score group. Diagnostic performance was evaluated using median clearance and volume of distribution, area under the antibiotic time-concentration curve (AUC), and achievement of free concentrations greater than a minimum inhibitory concentration (MIC) of 16 mu g/mL for at least 50% of the dose interval (fT > MIC >= 50%). Alternative dosing strategies were explored in silico. RESULTS: The ARC score was 100% sensitive and 71.4% specific for detecting increased clearance, increased volume of distribution, decreased AUC, and fT > MIC < 50% at an MIC of 16 mu g/mL. The area under the receiver operating characteristic curve was 0.86 for each, reflecting a high degree of diagnostic accuracy for the ARC score. Serum creatinine less than 0.6 mg/dL had comparable specificity (71.4%) but was less sensitive (66.7%) and accurate (area under the receiver operating characteristic curve, 0.69) for detecting higher clearance rates. Monte Carlo pharmacokinetic simulations demonstrated increased time at therapeutic drug levels with extended infusion dosing at a drug cost savings of up to 66.7% over multiple intermittent dosing regimens. CONCLUSION: Given its ability to predict antimicrobial clearance above population medians, which could compromise therapy, the ARC score should be considered as a means to identify patients at risk for subtherapeutic antibiotic levels. Adequately powered studies should prospectively confirm the utility of the ARC score and the role of antimicrobial therapeutic drug monitoring in such patients. (Copyright (C) 2014 by Lippincott Williams & Wilkins) C1 [Akers, Kevin S.; Niece, Krista L.; Chung, Kevin K.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Akers, Kevin S.; Murray, Clinton K.] San Antonio Mil Med Ctr, Infect Dis Serv, Dept Med, Ft Sam Houston, TX USA. [Cannon, Jeremy W.] San Antonio Mil Med Ctr, Dept Surg, Ft Sam Houston, TX USA. [Cota, Jason M.] Univ Incarnate Word Feik Sch Pharm, Dept Pharm Practice, San Antonio, TX USA. [Akers, Kevin S.; Chung, Kevin K.; Murray, Clinton K.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. [Cannon, Jeremy W.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. RP Akers, KS (reprint author), JBSA Ft Sam Houston, US Army Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM kevin.s.akers.mil@mail.mil FU Defense Medical Research & Development Program (DMRDP) Military Infectious Disease Clinical Trial Award (MIDCTA) [D_MIDCTA_I_12_J2_299] FX This study was conducted under a protocol reviewed and approved by the US Army Medical Research and Materiel Command Institutional Review Board and in accordance with the approved protocol H-09-059. This work was supported by Defense Medical Research & Development Program (DMRDP) Military Infectious Disease Clinical Trial Award (MIDCTA) #D_MIDCTA_I_12_J2_299. NR 18 TC 8 Z9 8 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD SEP PY 2014 VL 77 SU 2 BP S163 EP S170 DI 10.1097/TA.0000000000000191 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA AO2BL UT WOS:000341120400019 PM 24770557 ER PT J AU Belenkiy, SM Batchinsky, AI Park, TS Luellen, DE Serio-Melvin, ML Cancio, LC Pamplin, JC Chung, KK Salinas, J Cannon, JW AF Belenkiy, Slava M. Batchinsky, Andriy I. Park, Timothy S. Luellen, David E. Serio-Melvin, Maria L. Cancio, Leopoldo C. Pamplin, Jeremy C. Chung, Kevin K. Salinas, Jose Cannon, Jeremy W. TI Automated inhaled nitric oxide alerts for adult extracorporeal membrane oxygenation patient identification SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Adult respiratory distress syndrome; extracorporeal membrane oxygenation; automated alert; inhaled nitric oxide ID RESPIRATORY-DISTRESS-SYNDROME; ACUTE LUNG INJURY; FAILURE; SUPPORT; STRATEGIES; ARDS; VENTILATION; MORTALITY; RESCUE; TIME AB BACKGROUND: Recently, automated alerts have been used to identify patients with respiratory failure based on set criteria, which can be gleaned from the electronic medical record (EMR). Such an approach may also be useful for identifying patients with severe adult respiratory distress syndrome (ARDS) who may benefit from extracorporeal membrane oxygenation (ECMO). Inhaled nitric oxide (iNO) is a common rescue therapy for severe ARDS which can be easily tracked in the EMR, and some patients started on iNO may have indications for initiating ECMO. This case series summarizes our experience with using automated electronic alerts for ECMO team activation focused particularly on an alert triggered by the initiation of iNO. METHODS: After a brief trial evaluation, our Smart Alert system generated an automated page and e-mail alert to ECMO team members whenever a nonzero value for iNO appeared in the respiratory care section of our EMR. If iNO was initiated for severe respiratory failure, a detailed evaluation by the ECMO team determined if ECMO was indicated. For those patients managed with ECMO, we tabulated baseline characteristics, indication for ECMO, and outcomes. RESULTS: From September 2012 to July 2013, 45 iNO alerts were generated on 42 unique patients. Six patients (14%) met criteria for ECMO. Of these, four were identified exclusively by the iNO alert. At the time of the alert, the median PaO2-to-FIO2 ratio was 64 mm Hg (range, 55-107 mm Hg), the median age-adjusted oxygenation index was 73 (range, 51-96), and the median Murray score was 3.4 (range, 3-3.75), indicating severe respiratory failure. Median time from iNO alert to ECMO initiation was 81 hours (range, -2-292 hours). Survival to hospital discharge was 83% in those managed with ECMO. CONCLUSION: Automated alerts may be useful for identifying patients with severe ARDS who may be ECMO candidates. (J Trauma Acute Care Surg. 2014; 77: S184-S189. Copyright (C) 2014 by Lippincott Williams & Wilkins) C1 [Belenkiy, Slava M.; Batchinsky, Andriy I.; Luellen, David E.; Serio-Melvin, Maria L.; Cancio, Leopoldo C.; Chung, Kevin K.; Salinas, Jose] US Army Inst Surg Res, San Antonio, TX USA. [Park, Timothy S.; Pamplin, Jeremy C.; Cannon, Jeremy W.] San Antonio Mil Med Ctr, Dept Surg, San Antonio, TX USA. [Pamplin, Jeremy C.; Chung, Kevin K.; Cannon, Jeremy W.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Cannon, JW (reprint author), JBSA Ft Sam Houston, Dept Surg, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA. EM jeremy.w.cannon2.mil@mail.mil FU Defense Medical Research and Development Program FX J.W.C. was funded by a grant from the Defense Medical Research and Development Program. NR 34 TC 0 Z9 0 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD SEP PY 2014 VL 77 SU 2 BP S184 EP S189 DI 10.1097/TA.0000000000000343 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA AO2BL UT WOS:000341120400022 PM 25159353 ER PT J AU Clifford, JL Fowler, M Hansen, JJ Cheppudira, B Nyland, JE Salas, MM McGhee, LL Petz, LN Loyd, DR AF Clifford, John L. Fowler, Marcie Hansen, Jacob J. Cheppudira, Bopiah Nyland, Jennifer E. Salas, Margaux M. McGhee, Laura L. Petz, Lawrence N. Loyd, Dayna R. TI State of the science review: Advances in pain management in wounded service members over a decade at war SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Review ID OPERATIONS ENDURING FREEDOM; NEUROPATHIC PAIN; VIRTUAL-REALITY; IRAQI FREEDOM; MORPHINE-TOLERANCE; RHEUMATOID-ARTHRITIS; PHARMACOGENOMIC-TWIN; MUSCULOSKELETAL PAIN; REUPTAKE INHIBITOR; OPIOID ANALGESIA AB The pain conditions and comorbidities experienced by injured service members and the challenge of pain management by the military medical system offer a unique opportunity to inform pain management and medical research. In this article, acute and chronic pain issues, current treatment options and limitations, as well as novel approaches to pain management are discussed within the context of combat casualty care, from the battlefield to hospitalization and rehabilitation. This review will also highlight the current pain management limitations that need to be addressed in future clinical and basic science research to improve care for our nation's injured service members. (Copyright (C) 2014 by Lippincott Williams & Wilkins) C1 [Clifford, John L.; Fowler, Marcie; Hansen, Jacob J.; Cheppudira, Bopiah; Nyland, Jennifer E.; Salas, Margaux M.; Petz, Lawrence N.; Loyd, Dayna R.] San Antonio Mil Med Ctr, US Army Inst Surg Res, Pain Management Res Area, San Antonio, TX USA. [Hansen, Jacob J.] San Antonio Mil Med Ctr, US Army Inst Surg Res, Dept Anesthesiol, San Antonio, TX USA. [McGhee, Laura L.] Def & Vet Pain Management Initiat, Washington, DC USA. RP Clifford, JL (reprint author), JBSA Ft Sam Houston, 3698 Chambers Pass, San Antonio, TX 78234 USA. EM John.L.Clifford11.civ@mail.mil RI Nyland, Jennifer/J-8329-2015; OI Nyland, Jennifer/0000-0002-4549-3617; Averitt, Dayna/0000-0001-8345-4988 FU United States Army Medical Research and Materiel Command Combat Casualty Care Research; Clinical and Rehabilitative Medicine Research programs - Department of Defense [D13ARATDA_I_13_J8_503]; Defense Health Program [6.7D_OSD_I_13_J7_610] FX This work was supported by the United States Army Medical Research and Materiel Command Combat Casualty Care Research and the Clinical and Rehabilitative Medicine Research programs and in part funded by Department of Defense grant D13ARATDA_I_13_J8_503 awarded to D. R. L. and Defense Health Program grant 6.7D_OSD_I_13_J7_610 awarded to J.J.H. NR 101 TC 6 Z9 6 U1 2 U2 10 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD SEP PY 2014 VL 77 SU 2 BP S228 EP S236 DI 10.1097/TA.0000000000000403 PG 9 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA AO2BL UT WOS:000341120400030 PM 25159359 ER PT J AU Kheirabadi, BS Terrazas, IB Miranda, N Estep, JS Corona, BT Kragh, JF Dubick, MA AF Kheirabadi, Bijan S. Terrazas, Irasema B. Miranda, Nahir Estep, J. Scot Corona, Benjamin T. Kragh, John F., Jr. Dubick, Michael A. TI Long-term effects of Combat Ready Clamp application to control junctional hemorrhage in swine SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Combat Ready Clamp; hemorrhage control; junctional bleeding; junctional tourniquet; swine ID NEUROMUSCULAR RECOVERY; VASCULAR INJURY; SURVIVAL MODEL; SUS-SCROFA AB BACKGROUND: Groin application of Combat Ready Clamp (CRoC) in pigs elicits an acute inflammation in underlying ischemic tissues. This study examined functional recovery of pigs' hind leg(s) following 2 hours of CRoC application. METHODS: Left femoral arteries were isolated and injured in anesthetized pigs. Following 25% hemorrhage, CRoC was applied on the inguen for 2 hours (n = 6), and wounds were covered with combat gauze (CG). Bleeding was treated in the control animals (n = 5) with CG only. Next, CRoC and CG were removed, arteries were repaired and reflowed, and animals were recovered. The legs' mobility was scored daily, and their neuromuscular functions were measured on Days 7 and 14. Computed tomographic angiography and blood analysis were performed on Days 0, 2, 7, and 14. Pigs were then euthanized, and tissues were collected for histology. Umbilicus application of CRoC was also tested in four pilot experiments. RESULTS: Inguinal application of CRoC with 524 +/- 12 mm Hg pressure occluded iliac arteries and collateral circulation. Following surgical repair, blood flow to the arteries was restored, and five of six CRoC-applied legs recovered full mobility within 9 days. Control-treated legs recovered full function in 3 days (p = 0.001). At 2 weeks, muscle strength of CRoC-applied legs was diminished (p < 0.05 vs. baselines or controls). Injury biomarkers in the CRoC group increased severalfold compared with the controls on Day 2 but returned to baseline afterward. Histologic changes were mostly mild and indicative of ischemia in the CRoC group. Umbilical application of CRoC required higher pressure (625 +/- 8 mm Hg) and caused gross ischemic necrosis of lumbar muscles with significant disabilities. CONCLUSION: Two-hour inguinal application of CRoC caused mild and reversible ischemic injuries, which delayed full recovery of the limb function by a few days. In contrast, 2-hour umbilicus application of CRoC resulted in extensive muscle necrosis with functional disabilities. While CRoC seems safe and effective for inguinal application, other tourniquets should be evaluated for treating bilateral junctional bleeding. (Copyright (C) 2014 by Lippincott Williams & Wilkins) C1 [Kheirabadi, Bijan S.; Terrazas, Irasema B.; Miranda, Nahir; Estep, J. Scot; Corona, Benjamin T.; Kragh, John F., Jr.; Dubick, Michael A.] JBSA Ft Sam Houston, US Army Inst Surg Res, San Antonio, TX 78234 USA. RP Kheirabadi, BS (reprint author), JBSA Ft Sam Houston, 3650 Chambers Pass,BHT2,Bldg 3610, San Antonio, TX 78234 USA. EM bijan.s.kheirabadi.civ@mail.mil FU Veterinary Support Branch (VSB) FX We thank our colleague Dr. Harold Klemcke for his careful review and editorial assistance of the manuscript. We also thank the Veterinary Support Branch (VSB) for their support and assistance in conducting these large animal experiments. We also thank the excellent technical assistance provided by Mrs. Mary Gonzales; Ms. Dana Grubbs; Mrs. Shawn Chamrad, a member of VSB; and Ms. Janet Roe. NR 14 TC 5 Z9 5 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD SEP PY 2014 VL 77 SU 2 BP S101 EP S108 DI 10.1097/TA.0000000000000350 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA AO2BL UT WOS:000341120400009 PM 25159342 ER PT J AU Liu, NT Holcomb, JB Wade, CE Darrah, MI Salinas, J AF Liu, Nehemiah T. Holcomb, John B. Wade, Charles E. Darrah, Mark I. Salinas, Jose TI Evaluation of standard versus nonstandard vital signs monitors in the prehospital and emergency departments: Results and lessons learned from a trauma patient care protocol SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Prehospital physiologic data; lifesaving interventions; vital signs; signal quality; automatic data processing ID LIFESAVING INTERVENTIONS; OUTCOMES; TRIAGE; NEED AB BACKGROUND: This study aimed to determine the effectiveness of using a wireless, portable vital signs monitor (WVSM) for predicting the need for lifesaving interventions (LSIs) in the emergency department (ED) and use a multivariate logistic regression model to determine whether the WVSM was an improved predictor of LSIs in the ED over the standard of care monitor currently being used. METHODS: This study analyzed 305 consecutive patients transported from the scene via helicopter to a Level I trauma center. For 104 patients in the study, a WVSM was also attached to the patient's arm and used to record and display prehospital and hospital physiologic data in real time on a handheld computer and in the trauma bay. Multivariate logistic regression analyses were performed for accuracy in predicting needs for LSIs in control and WVSM subjects. In addition, receiver operating characteristic curves were obtained to examine the discriminating power of the models for the outcome of one or more LSIs in the ED. RESULTS: Of the 305 patients, 73 underwent 109 LSIs in the ED. Of these, 21 patients wore the WVSM during transport in addition to the standard monitor. Logistic regression analysis revealed that heart rate, respiratory rate, and systolic blood pressure were significantly associated with an increased risk for LSIs in the ED (p < 0.05). Receiver operating characteristic curve analysis also demonstrated better prediction for LSIs performed in the ED in WVSM subjects than in control subjects (area under the curve, 0.86 vs. 0.81, respectively). CONCLUSION: The WVSM system leads to improved LSI accuracy in the ED. In addition, many important lessons have been learned in preparation for this study. Adoption of nonstandard vital signs monitors into critical care/trauma medicine may require a new paradigm of personnel education, training, and practice. (Copyright (C) 2014 by Lippincott Williams & Wilkins) C1 [Liu, Nehemiah T.; Salinas, Jose] US Army Inst Surg Res, San Antonio, TX USA. [Holcomb, John B.; Wade, Charles E.] Univ Texas Hlth Sci Ctr Houston, Dept Surg, Ctr Translat Injury Res, Houston, TX 77030 USA. [Darrah, Mark I.] Athena GTX Inc, Des Moines, IA USA. RP Liu, NT (reprint author), JBSA Ft Sam Houston, US Army Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM nehemiah.liu@us.army.mil FU National Trauma Institute, the Combat Casualty Care Research Program; State of Texas Emerging Technology Fund FX This work was supported by the National Trauma Institute, the Combat Casualty Care Research Program, and the State of Texas Emerging Technology Fund. NR 13 TC 3 Z9 4 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD SEP PY 2014 VL 77 SU 2 BP S121 EP S126 DI 10.1097/TA.0000000000000192 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA AO2BL UT WOS:000341120400012 PM 24770560 ER PT J AU Mazzoli, RA Gross, KR Butler, FK AF Mazzoli, Robert A. Gross, Kirby R. Butler, Frank K. TI The use of rigid eye shields (Fox shields) at the point of injury for ocular trauma in Afghanistan SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Eye injuries; eye shields; eye trauma; combat injuries; casualty care AB BACKGROUND: Unlike hemorrhagic injuries in which direct pressure is indicated, any pressure placed on the eye after penetrating trauma can significantly worsen the injury by expulsing intraocular contents. The accepted first response measure for obvious or suspected penetrating ocular injury is placement of a rigid shield that vaults the eye so as to prevent accidental iatrogenic aggravation during transport to the ophthalmologist. Patching and placing intervening gauze between the shield and the eye are both contraindicated. Anecdotally, compliance with these recommendations is poor in the military and civilian communities alike; however, published studies documenting compliance are uniformly lacking. This study was undertaken to provide such an evaluation. METHODS: In this retrospective observational study, the Department of Defense Trauma Registry was reviewed to identify eye injuries in Afghanistan from 2010 to 2012 and to examine compliance with eye shield recommendations. One hundred fifty-seven records of eye casualties were identified and categorized according to diagnostic codes, noting use of a shield. A subset of 30 records was further analyzed for compliance with other core treatment measures specified by the operant Clinical Practice Guideline. Because comparative studies do not exist, simple statistical analysis was performed. RESULTS: Overall, 39% of eye injuries received a shield at the point of injury (61% failure), ranging from 0% to 50% between diagnostic subgroups. Subset analysis revealed that only 4.2% of injuries were successfully mitigated at the point of injury (95.8% failure). CONCLUSION: In one of the few studies documenting the use of eye shields after ocular trauma, anecdotal reports of poor, inadequate, or incorrect compliance with basic recommendations were substantiated. Several factors may account for these findings. Corrective efforts should include enhanced educational emphasis and increased shield availability. (Copyright (C) 2014 by Lippincott Williams & Wilkins) C1 [Mazzoli, Robert A.] Uniformed Serv Univ Hlth Sci, DoD VA Vis Ctr Excellence, Bethesda, MD 20814 USA. [Mazzoli, Robert A.] Madigan Army Med Ctr, Dept Ophthalmol, Tacoma, WA 98431 USA. [Gross, Kirby R.; Butler, Frank K.] US Army Inst Surg Res, Joint Trauma Syst, San Antonio, TX USA. RP Mazzoli, RA (reprint author), Madigan Army Med Ctr, Dept Ophthalmol, Tacoma, WA 98431 USA. EM Robert.a.mazzoli.civ@mail.mil FU US Army Institute of Surgical Research, Joint Trauma System, Fort Sam Houston, Texas FX This study was performed under the auspices of the US Army Institute of Surgical Research, Joint Trauma System, Fort Sam Houston, Texas. NR 15 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD SEP PY 2014 VL 77 SU 2 BP S156 EP S162 DI 10.1097/TA.0000000000000391 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA AO2BL UT WOS:000341120400018 PM 25159350 ER PT J AU Mitchell, TA Hutchison, T Becker, TE Aden, JK Blackbourne, L White, CE AF Mitchell, Thomas A. Hutchison, Tara Becker, Tyson E. Aden, James K. Blackbourne, Lorne White, Christopher E. TI Nontherapeutic laparotomy in American combat casualties: A 10-year review SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Review DE Laparotomy; nontherapeutic laparotomy; Operation Enduring Freedom; Operation Iraqi Freedom ID SELECTIVE NONOPERATIVE MANAGEMENT; ABDOMINAL-TRAUMA AB BACKGROUND: The civilian literature has expanded the indications for selective nonoperative management (SNOM) for abdominal trauma to minimize morbidity from nontherapeutic laparotomies (NTLs); however, this treatment modality remains controversial and rare in austere settings. This study aimed to quantify the percentage of NTL and incidence of failed SNOM performed in theater and to define each of their respective intra-abdominal-related morbidities. METHODS: A retrospective evaluation of all patients who underwent a laparotomy from 2002 to 2011 during Operation Iraqi Freedom (OIF) and Operation Enduring Freedom (OEF) was performed for patients who survived a minimum of 24 hours. With the use of DRG International Classification of Diseases-9th Rev. procedure codes, a therapeutic laparotomy was defined by the presence of a defined intraperitoneal or retroperitoneal procedure; an NTL was defined by the absence of a defined intraperitoneal or retroperitoneal procedure. Second, patients transferred from North American Treaty Organization Role II to Role III medical treatment facilities to be operated on were deemed failed SNOM. Finally, intra-abdominal complications and mortality were identified for patients undergoing therapeutic laparotomy, NTL, and failed SNOM. RESULTS: Blunt, burn, and penetrating injuries accounted for 38.5% (n = 490), 1.1% (n = 14), and 60.4% (n = 769) of all laparotomies in the OEF and OIF, respectively. Thirty-two percent of all laparotomies performed during the OEF and OIF campaigns were NTL; specifically, the NTL rates in OEF and OIF were 38.2% and 28.6%, respectively. In addition, 31.6% and 32.2% of all penetrating and blunt injury mechanisms resulted in an NTL, respectively. The percentage of all patients identified as failing SNOM was 7.5% (n = 95). The early intra-abdominal complication rate for failed SNOM and for all patients undergoing NTL was 2.1% and 1.7%, respectively. CONCLUSION: The OIF and OEF combined NTL rate was 32.1%, with an associated 1.7% intra-abdominal early complication rate. The infrequent application of SNOM in a deployed military environment is likely secondary to unpredictable fragmentation trajectories and related blast injury patterns, limited medical resources including computed tomography, and a complex aeromedical evacuation system preventing serial observation. (Copyright (C) 2014 by Lippincott Williams & Wilkins) C1 [Mitchell, Thomas A.; Becker, Tyson E.; Blackbourne, Lorne; White, Christopher E.] San Antonio Mil Med Ctr, San Antonio, TX USA. [Hutchison, Tara; Aden, James K.] US Army Inst Surg Res, San Antonio, TX USA. RP White, CE (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA. EM christopher.eric.white@us.army.mil NR 14 TC 1 Z9 1 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD SEP PY 2014 VL 77 SU 2 BP S171 EP S175 DI 10.1097/TA.0000000000000367 PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA AO2BL UT WOS:000341120400020 PM 25159351 ER PT J AU Nair, PM Pidcoke, HF Cap, AP Ramasubramanian, AK AF Nair, Prajeeda M. Pidcoke, Heather F. Cap, Andrew P. Ramasubramanian, Anand K. TI Effect of cold storage on shear-induced platelet aggregation and clot strength SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Platelet storage; refrigeration; SIPA; clot strength; hemorrhage ID FRESH WHOLE-BLOOD; FLUID RESUSCITATION; FIBRIN CLOT; HEMOSTATIC EFFECTIVENESS; TRANSFUSION; COAGULATION; ACTIVATION; TRAUMA; 37-DEGREES-C; 22-DEGREES-C AB BACKGROUND: Platelets (PLTs) participate in hemostasis and save lives following trauma. PLTs for transfusion are maintained at room temperature (RT, 22 degrees C), limiting viability to 5 days because of metabolic compromise and high risk of bacterial contamination. RT storage may result in weaker clots, delaying hemorrhage control, whereas cold storage (4 degrees C) could permit longer PLT shelf life and result in a more hemostatic product. In this study, we characterized the effect of storage temperature on shear-induced PLT aggregation, clot formation, and strength. METHODS: PLTs obtained from phlebotomized blood or by apheresis were stored at RT or 4 degrees C for 5 days, and PLT aggregation and clot strength were assessed at 37 degrees C. We studied PLT aggregation at steady and complex patterns of shear rates (500-2,500 per second) by flow cytometry, and the kinetics of clot formation and strength were measured using turbidity and dynamic mechanical analysis, respectively. RESULTS: PLT aggregation was higher in 4 degrees C-stored samples on Day 5 compared with fresh or RT-stored samples at all shear rates tested (fresh vs. 4 degrees C and RT vs. 4 degrees C, p < 0.05). PLTs stored at 4 degrees C for 5 days formed significantly stronger clots compared with fresh or RT-stored samples as quantified by turbidity and elastic moduli measurements (fresh vs. 4 degrees C and RT vs. 4 degrees C, p < 0.05). CONCLUSION: Our results show that cold-stored PLTs are more responsive to aggregation stimuli and form stronger clots, presumably because of thicker fibrin strands. These data suggest that the superior functionality of cold-stored PLTs may support faster hemostasis for acutely bleeding in trauma patients compared with RT-stored PLTs. (J Trauma Acute Care Surg. 2014; 77: S88-S93. Copyright (C) 2014 by Lippincott Williams & Wilkins) C1 [Nair, Prajeeda M.; Ramasubramanian, Anand K.] Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX 78249 USA. [Pidcoke, Heather F.; Cap, Andrew P.] US Army Inst Surg Res, Blood Res Program, San Antonio, TX 78234 USA. RP Ramasubramanian, AK (reprint author), Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX 78249 USA. EM andrew.p.cap.mil@mail.mil; anand.ramasubramanian@utsa.edu FU Department of Defense [W81XWH-13-P-0146] FX This study was supported by a contract from the Department of Defense (W81XWH-13-P-0146). NR 45 TC 16 Z9 16 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD SEP PY 2014 VL 77 SU 2 BP S88 EP S93 DI 10.1097/TA.0000000000000327 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA AO2BL UT WOS:000341120400007 PM 25159368 ER PT J AU Napierala, MA Rivera, JC Burns, TC Murray, CK Wenke, JC Hsu, JR AF Napierala, Matthew A. Rivera, Jessica C. Burns, Travis C. Murray, Clinton K. Wenke, Joseph C. Hsu, Joseph R. CA Skeletal Trauma Res Educ TI Infection reduces return-to-duty rates for soldiers with Type III open tibia fractures SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Infection; return to duty; open tibia fracture; type III ID INJURIES; COMPLICATIONS; PREVENTION; MANAGEMENT; HISTORY; WOUNDS AB BACKGROUND: Infection is a potentially devastating complication following severe lower extremity trauma, but its impact on the outcomes of combat casualties remains unclear. We hypothesize that orthopedic infectious complications will have a negative impact on holistic patient outcome as measured by return-to-duty (RTD) and disability ratings among wounded soldiers. METHODS: We reviewed the medical records for 115 wounded soldiers who sustained a Type III open tibia fracture and tabulated the prevalence of infectious complications. We searched the Physical Evaluation Board database to determine the disability ratings of soldiers with and without an infection and how many of each group was able to return to active duty service. The average percent disability rating and RTD rates between groups were compared using an unpaired t test and chi(2) test, respectively. RESULTS: Overall, 40% of our cohort had an infectious complication of their fractured limb. Twenty-one soldiers were able to RTD, while 94 could not and were medically retired. Of those medically retired, 44% had an infection. The average percent disability among soldiers with infection was 55%, compared with 47% for those who were not infected (p = 0.1407). Soldiers who experienced any type of infectious complication (p = 0.0470) and having osteomyelitis (p = 0.0335) had a lower chance of RTD compared with those who had no infection. Having a deep soft tissue infection alone showed a strong trend toward decreased RTD rate (p = 0.0558). CONCLUSION: Infectious complications following severe lower extremity trauma significantly decrease the rate of RTD. In addition, the presence of infectious complications demonstrates a trend toward higher disability ratings in the combat wounded. (J Trauma Acute Care Surg. 2014; 77: S194-S197. Copyright (C) 2014 by Lippincott Williams & Wilkins) C1 [Napierala, Matthew A.; Rivera, Jessica C.; Burns, Travis C.] San Antonio Mil Med Ctr, Dept Orthopaed & Rehabil, San Antonio, TX 78234 USA. [Murray, Clinton K.] San Antonio Mil Med Ctr, Infect Dis Serv, Dept Med, San Antonio, TX 78234 USA. [Wenke, Joseph C.] US Army Inst Surg Res, San Antonio, TX USA. [Hsu, Joseph R.] Carolinas Med Ctr, Orthopaed Surg Serv, Charlotte, NC 28203 USA. RP Napierala, MA (reprint author), San Antonio Mil Med Ctr, Dept Orthopaed & Rehabil, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA. EM matthew.a.napierala.mil@mail.mil NR 18 TC 5 Z9 5 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD SEP PY 2014 VL 77 SU 2 BP S194 EP S197 DI 10.1097/TA.0000000000000364 PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA AO2BL UT WOS:000341120400024 PM 25159355 ER PT J AU O'Reilly, DJ Morrison, JJ Jansen, JO Apodaca, AN Rasmussen, TE Midwinter, MJ AF O'Reilly, David J. Morrison, Jonathan J. Jansen, Jan O. Apodaca, Amy N. Rasmussen, Todd E. Midwinter, Mark J. TI Prehospital blood transfusion in the en route management of severe combat trauma: A matched cohort study SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Combat injury; shock; hemorrhage; blood products; military trauma ID DAMAGE CONTROL RESUSCITATION; HEMOSTATIC RESUSCITATION; FLUID RESUSCITATION; IMPROVED SURVIVAL; INJURY SEVERITY; TRANEXAMIC ACID; COAGULOPATHY; MORTALITY; COAGULATION; HEMORRHAGE AB BACKGROUND: The value of prehospital blood transfusion (PHBTx) in the management of severe trauma has not been established. This study aimed to evaluate the effect of PHBTx on mortality in combat casualties. METHODS: This is a retrospective cohort study of casualties admitted to the field hospital at Camp Bastion, Afghanistan, by the Medical Emergency Response Team from May 2006 to March 2011. Participants were divided into two consecutive cohorts by the introduction of PHBTx. Paired groups of patients were chosen by combining propensity score methodology with detailed matching of injury profile. Thus recipients of PHBTx were matched with nonrecipients who would have received it had it been available. RESULTS: A total of 1,592 patients were identified. Of the 1,153 patients to whom PHBTx was potentially available, 310 received it (26.9%). The rate of severe injury (Injury Severity Score [ISS] > 15) rose from 28% before PHBTx was available to 43% thereafter (p < 0.001). Mortality in the latter group was higher (14% vs. 10%, p = 0.013) but not in the severely injured patients (32% vs. 28%, p = 0.343). Ninety-seven patients were paired. The mortality of matched patients who received PHBTx, compared with those with similar injury patterns who did not, was less than half (8.2% vs. 19.6%, p < 0.001). However, matched recipients had more prehospital interventions, reached hospital more quickly, and had lower heart rate at admission (all p < 0.05). Matched recipients received more red blood cells within 24 hours (median, 4 U; interquartile range [IQR], 2-10 U) than nonrecipients (median 0 U; IQR, 0-3.5 U) and more fresh frozen plasma (median, 2 U; IQR, 2-9 U vs. median, 0 U; IQR, 0-1 U) (both p < 0.001). CONCLUSION: An aggressive approach to damage control resuscitation including the use of PHBTx was associated with a large improvement in mortality. However, because of confounders resulting from changes in practice, the isolated contribution of PHBTx cannot be determined from this study. (Copyright (C) 2014 by Lippincott Williams & Wilkins) C1 [O'Reilly, David J.; Morrison, Jonathan J.; Jansen, Jan O.; Midwinter, Mark J.] RCDM, Acad Dept Mil Surg & Trauma, Birmingham BS15 2SQ, W Midlands, England. [Midwinter, Mark J.] Natl Inst Hlth Res, Surg Reconstruct & Microbiol Res Ctr, Birmingham, W Midlands, England. [Apodaca, Amy N.] US Army Inst Surg Res, Joint Trauma Syst, Ft Sam Houston, TX USA. [Rasmussen, Todd E.] US Combat Casualty Care Res Program, Ft Detrick, MD USA. RP Midwinter, MJ (reprint author), RCDM, Acad Dept Mil Surg & Trauma, ICT Ctr, Vincent Dr, Birmingham BS15 2SQ, W Midlands, England. EM Prof.MilSurg@rcdm.bham.ac.uk RI Midwinter, Mark/P-6264-2015; OI Midwinter, Mark/0000-0003-1836-7137; Morrison, Jonathan/0000-0001-7462-8456 NR 39 TC 12 Z9 12 U1 2 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD SEP PY 2014 VL 77 SU 2 BP S114 EP S120 DI 10.1097/TA.0000000000000328 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA AO2BL UT WOS:000341120400011 PM 25159344 ER PT J AU Pruitt, BA Rasmussen, TE AF Pruitt, Basil A., Jr. Rasmussen, Todd E. TI Vietnam (1972) to Afghanistan (2014): The state of military trauma care and research, past to present SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Editorial Material ID CASUALTY; WAR; MANAGEMENT; WARTIME; WOUNDS C1 [Pruitt, Basil A., Jr.] Joint Base Ft Sam Houston, US Army Inst Surg Res, Houston, TX USA. [Rasmussen, Todd E.] US Combat Casualty Care Res Program, Ft Detrick, MD 21702 USA. [Pruitt, Basil A., Jr.; Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. RP Rasmussen, TE (reprint author), US Combat Casualty Care Res Program, 722 Doughten St,Room 3, Ft Detrick, MD 21702 USA. EM todd.e.rasmussen.mil@mail.mil NR 13 TC 5 Z9 5 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD SEP PY 2014 VL 77 SU 2 BP S57 EP S65 DI 10.1097/TA.0000000000000419 PG 9 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA AO2BL UT WOS:000341120400002 PM 25159363 ER PT J AU Wampler, D Convertino, VA Weeks, S Hernandez, M Larrumbide, J Manifold, C AF Wampler, David Convertino, Victor A. Weeks, Shannon Hernandez, Michael Larrumbide, Jacob Manifold, Craig TI Use of an impedance threshold device in spontaneously breathing patients with hypotension secondary to trauma: An observational cohort feasibility study SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Permissive hypotension; impedance threshold device; prehospital; noninvasive therapy ID CEREBRAL-BLOOD-FLOW; FLUID RESUSCITATION; INSPIRATORY RESISTANCE; SYMPTOMS; CARE AB BACKGROUND: An impedance threshold device (ITD) intended for use in the spontaneously breathing patient has been shown to raise blood pressure in hypotensive patients. This device has not been evaluated in patients with hypotension secondary to trauma. This study focused on changes in key vital signs when the ITD was added to the paramedic treatment protocol for hypotensive patients with prehospital traumatic injury. METHODS: A 6-month prospective nonrandomized observational cohort study was conducted of 200 spontaneously breathing symptomatic adult patients with prehospital hypotension due to multiple causes; the patients of primary interest experienced a traumatic injury. Upon determination of hypotension (systolic blood pressure of approximately <= 90 mm Hg), standard therapy was initiated by application of the mask-style ITD. Vital signs were documented every 2 minutes to 5 minutes after intervention. A change in mean arterial pressure (MAP) with ITD use was the primary study endpoint. RESULTS: Of the 200 hypotensive subjects treated, 29 (3 were excluded because of incomplete data sets and 3 patients treated with the ITD were excluded because their blood pressure did not meet inclusion criterion) were hypotensive secondary to trauma. Their MAP increased from 60 mm Hg (SD, 11 mm Hg; 95% confidence interval [CI], 8.17-15.432) to 78 mm Hg (16 mm Hg; 95% CI, 12.43-23.46) (p = 0.001), without significant change in mean heart rate. Approximately 75% of the patients reported moderate to easy tolerance. Similar increases in MAP were observed in the nontraumatic patients, from 60 mm Hg (10 mm Hg; 95% CI, 9.4-11.5) to 70 (15; 95% CI, 13.4-16.7) (p = 0.0001). CONCLUSION: In this observational cohort study of patients with hypotension secondary to trauma, the ITD was well tolerated, and MAP as well as systolic and diastolic blood pressure were improved. The patients were not overresuscitated with this intervention. On the basis of these findings, additional studies in patients with hypotension secondary to traumatic injury should be performed to better define the need and benefit of additional fluid resuscitation when the ITD is used. (Copyright (C) 2014 by Lippincott Williams & Wilkins) C1 [Wampler, David; Larrumbide, Jacob; Manifold, Craig] Univ Texas Hlth Sci Ctr San Antonio, Dept Emergency Hlth Sci, San Antonio, TX 78229 USA. [Wampler, David; Weeks, Shannon; Hernandez, Michael; Manifold, Craig] San Antonio Fire Dept, San Antonio, TX USA. [Convertino, Victor A.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Weeks, Shannon] Southwest Texas Reg Advisory Council Trauma, San Antonio, TX USA. RP Wampler, D (reprint author), Univ Texas Hlth Sci Ctr San Antonio, 4201 Med Dr,Suite 120, San Antonio, TX 78229 USA. EM wamplerd@uthscsa.edu FU Combat Casualty Care Research Program, United States Department of Defense, United States Army Medical Research and Material Command [W81XWH-12-2-0027] FX This project was supported by the Combat Casualty Care Research Program, United States Department of Defense, United States Army Medical Research and Material Command (W81XWH-12-2-0027). NR 10 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD SEP PY 2014 VL 77 SU 2 BP S140 EP S145 DI 10.1097/TA.0000000000000368 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA AO2BL UT WOS:000341120400015 PM 25159347 ER PT J AU Meadows, JM Ching, BH Tabak, BD AF Meadows, Jeffery M. Ching, Brian H. Tabak, Benjamin D. TI Endovascular Use of Laparoscopic Babcock Graspers SO JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY LA English DT Editorial Material C1 [Meadows, Jeffery M.; Ching, Brian H.; Tabak, Benjamin D.] Tripler Army Med Ctr, Dept Radiol, Honolulu, HI 96859 USA. RP Meadows, JM (reprint author), Tripler Army Med Ctr, Dept Radiol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM jeffery.meadows@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1051-0443 EI 1535-7732 J9 J VASC INTERV RADIOL JI J. Vasc. Interv. Radiol. PD SEP PY 2014 VL 25 IS 9 BP 1447 EP 1447 DI 10.1016/j.jvir.2013.12.011 PG 1 WC Radiology, Nuclear Medicine & Medical Imaging; Peripheral Vascular Disease SC Radiology, Nuclear Medicine & Medical Imaging; Cardiovascular System & Cardiology GA AO1JI UT WOS:000341068000020 PM 25150904 ER PT J AU Massaro, E Bagnoli, F Guazzini, A Olsson, H AF Massaro, Emanuele Bagnoli, Franco Guazzini, Andrea Olsson, Henrik TI A cognitive-inspired algorithm for growing networks SO NATURAL COMPUTING LA English DT Article DE Complex networks; Computational modelling; Growing networks ID MODEL AB We present models for generating different classes of networks by adopting simple local strategies and an original model of the evolutionary dynamics and growth of on-line social networks. The model emulates people's strategies for acquiring information in social networks, emphasising the local subjective view of an individual and what kind of information the individual can acquire when arriving in a new social context. We assume that the strategy proceeds through two phases: (a) a discovery phase, in which the individual becomes aware of the surrounding world and (b) an elaboration phase, in which the individual elaborates locally the information trough a cognitive-inspired algorithm. Model generated networks reproduce the main features of both theoretical and real-world networks, such as high clustering coefficient, low characteristic path length, strong division in communities, and variability of degree distributions. C1 [Massaro, Emanuele] Univ Florence, Dept Informat Engn, Florence, Italy. [Massaro, Emanuele] Univ Florence, Ctr Study Complex Syst, Florence, Italy. [Massaro, Emanuele] Carnegie Mellon Univ, Dept Civil & Environm Engn, Pittsburgh, PA 15213 USA. [Bagnoli, Franco] Univ Florence, Dept Phys & Astron, Ctr Study Complex Syst, Florence, Italy. [Bagnoli, Franco] Ist Nazl Fis Nucl, I-50125 Florence, Italy. [Guazzini, Andrea] Univ Florence, Dept Sci Educ & Psychol, Ctr Study Complex Syst, Florence, Italy. [Olsson, Henrik] Max Planck Inst Human Dev, Ctr Adapt Behav & Cognit, Berlin, Germany. RP Massaro, E (reprint author), US Army Engn Res Dev Ctr, Risk & Decis Sci Team, 696 Virginia Rd, Concord, MA 01742 USA. EM ema.massaro@gmail.com; franco.bagnoli@unifi.it; andrea.guazzini@unifi.it; h.olsson@warwick.ac.uk RI Olsson, Henrik/G-7697-2011; Bagnoli, Franco/K-6904-2015 OI Olsson, Henrik/0000-0002-0099-7862; Bagnoli, Franco/0000-0002-6293-0305 NR 22 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1567-7818 EI 1572-9796 J9 NAT COMPUT JI Nat. Comput. PD SEP PY 2014 VL 13 IS 3 SI SI BP 379 EP 390 DI 10.1007/s11047-014-9444-7 PN 1 PG 12 WC Computer Science, Artificial Intelligence; Computer Science, Interdisciplinary Applications; Computer Science, Theory & Methods SC Computer Science GA AO1QZ UT WOS:000341089700009 ER PT J AU Longaker, MT Rohrich, RJ Greenberg, L Furnas, H Wald, R Bansal, V Seify, H Tran, A Weston, J Korman, JM Chan, R Kaufman, D Dev, VR Mele, JA Januszyk, M Cowley, C McLaughlin, P Beasley, B Gurtner, GC AF Longaker, Michael T. Rohrich, Rod J. Greenberg, Lauren Furnas, Heather Wald, Robert Bansal, Vivek Seify, Hisham Tran, Anthony Weston, Jane Korman, Joshua M. Chan, Rodney Kaufman, David Dev, Vipul R. Mele, Joseph A. Januszyk, Michael Cowley, Christy McLaughlin, Peggy Beasley, Bill Gurtner, Geoffrey C. TI A Randomized Controlled Trial of the embrace Advanced Scar Therapy Device to Reduce Incisional Scar Formation SO PLASTIC AND RECONSTRUCTIVE SURGERY LA English DT Article ID TOPICAL SILICONE GEL; HYPERTROPHIC SCARS; LINEAR SCARS; PREVENTION; MANAGEMENT; SURGERY; PATIENT; SHEETS AB Background: Scarring represents a significant biomedical burden in clinical medicine. Mechanomodulation has been linked to scarring through inflammation, but until now a systematic approach to attenuate mechanical force and reduce scarring has not been possible. Methods: The authors conducted a 12-month, prospective, open-label, randomized, multicenter clinical trial to evaluate abdominoplasty scar appearance following postoperative treatment with the embrace Advanced Scar Therapy device to reduce mechanical forces on healing surgical incisions. Incisions from 65 healthy adult subjects were randomized to receive embrace treatment on one half of an abdominoplasty incision and control treatment (surgeon's optimal care methods) on the other half. The primary endpoint for this study was the difference between assessments of scar appearance for the treated and control sides using the visual analogue scale scar score. Results: Final 12-month study photographs were obtained from 36 subjects who completed at least 5 weeks of dressing application. The mean visual analogue scale score for embrace-treated scars (2.90) was significantly improved compared with control-treated scars (3.29) at 12 months (difference, 0.39; 95 percent confidence interval, 0.14 to 0.66; p= 0.027). Both subjects and investigators found that embrace-treated scars demonstrated significant improvements in overall appearance at 12 months using the Patient and Observer Scar Assessment Scale evaluation (p = 0.02 and p < 0.001, respectively). No serious adverse events were reported. Conclusions: These results demonstrate that the embrace device significantly reduces scarring following abdominoplasty surgery. To the authors' knowledge, this represents the first level I evidence for postoperative scar reduction. C1 Stanford Univ, Dept Surg, Div Plast & Reconstruct Surg, Stanford, CA 94305 USA. Plast Surg Associates, Macon, GA USA. Aesthet Inst, Raipur, Madhya Pradesh, India. Elite MD Inc, Danville, CA USA. Newport Plast & Reconstruct Surg Associates, Newport Beach, CA USA. Atherton Plast Surg, Menlo Pk, CA USA. Korman Plast Surg, Mountain View, CA USA. Kaufman & Clark Plast Surg, Folsom, CA USA. VIP DEV MD, Bakersfield, CA USA. Walnut Creek Plast Surg, Walnut Creek, CA USA. Neodyne Biosci Inc, Menlo Pk, CA USA. Univ Texas SW Med Ctr Dallas, Dept Plast Surg, Arlington Plast Surg, Dallas, TX USA. US Army Inst Surg Res, Clin Div, San Antonio, TX USA. US Army Inst Surg Res, Burn Ctr, San Antonio, TX USA. RP Longaker, MT (reprint author), Stanford Univ, Dept Surg, Div Plast & Reconstruct Surg, Hagey Lab Pediat Regenerat Med, 257 Campus Dr West, Stanford, CA 94305 USA. EM longaker@stanford.edu; ggurtner@stanford.edu FU NLM NIH HHS [T15 LM007033] NR 26 TC 10 Z9 10 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0032-1052 EI 1529-4242 J9 PLAST RECONSTR SURG JI Plast. Reconstr. Surg. PD SEP PY 2014 VL 134 IS 3 BP 536 EP 546 DI 10.1097/PRS.0000000000000417 PG 11 WC Surgery SC Surgery GA AO1JU UT WOS:000341069200017 PM 24804638 ER PT J AU Thames, K AF Thames, Knox TI FORGING A TRANS-ATLANTIC PARTNERSHIP ON RELIGIOUS REEDOM SO REVIEW OF FAITH & INTERNATIONAL AFFAIRS LA English DT Article C1 [Thames, Knox] US Army War Coll, Carlisle, PA USA. NR 26 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1557-0274 EI 1931-7743 J9 REV FAITH INT AFF JI Rev. Faith Int. Aff. PD FAL PY 2014 VL 12 IS 3 BP 1 EP 8 DI 10.1080/15570274.2014.943613 PG 8 WC Religion SC Religion GA AO0NI UT WOS:000341006200001 ER PT J AU Carey, TW Shaw, KA Weber, ML DeVine, JG AF Carey, Timothy W. Shaw, K. Aaron Weber, Marissa L. DeVine, John G. TI Effect of the degree of reverse Trendelenburg position on intraocular pressure during prone spine surgery: a randomized controlled trial SO SPINE JOURNAL LA English DT Article DE Postoperative vision loss; Intraocular pressure; Reverse Trendelenburg; Prone; Spine; Surgery ID ISCHEMIC OPTIC NEUROPATHY; RETINAL ARTERY-OCCLUSION; VISION LOSS; VISUAL-LOSS; COMPLICATION; HYPOTENSION; AMAUROSIS; RISK AB BACKGROUND CONTEXT: Postoperative vision loss complicates an estimated 1 in 1,100 prone spine surgical cases. This complication has been attributed to ischemic optic neuropathy, with one proposed reason being perioperative elevations in intraocular pressure (IOP). Previous research has studied the effects of table inclination on IOP in awake volunteers; however, the effects in spine surgery patients have not been investigated for reverse Trendelenburg positioning using a prospective, randomized controlled study design. PURPOSE: To assess the effect of table inclination on IOP in patients undergoing prone spine surgery. STUDY DESIGN: Single-center, prospective randomized controlled study. PATIENT SAMPLE: Nineteen patients with no history of eye pathology, undergoing prone spine surgery at Dwight D. Eisenhower Army Medical Center, were randomly assigned to a table position: neutral, 5 degrees, or 10 degrees of reverse Trendelenburg. OUTCOME MEASURES: Intraocular pressure, mean arterial pressure (MAP), estimated blood loss, fluid resuscitation, and ophthalmologic complication were assessed before and after induction and at incremental times during surgery, beginning at 30 minutes, 60 minutes, and 60-minute increments thereafter. METHODS: Multivariate analyses evaluated surgical time, IOP, MAP, estimated blood loss, and fluid resuscitation as a function of table inclination to determine the effect of patient positioning on identified risk factors for postoperative vision loss. RESULTS: Surgical times ranged from 33 to 325 minutes. A rapid increase in IOP was noted after prone positioning, with continued increases as time elapsed. The neutral group exhibited statistically higher IOP compared with the 5 degrees reverse Trendelenburg group after 60 minutes and the 10 degrees group through 60 minutes of surgery. The trend continued through 120 minutes; however, because of a lack of power, we were unable to determine the statistical significance. There were no statistically significant differences between the 5 degrees and 10 degrees reverse Trendelenburg groups. CONCLUSIONS: Reverse Trendelenburg positioning elicits decreased IOP compared with prone positioning for surgery times less than 120 minutes. Ten degrees of reverse Trendelenburg attenuate the rise in IOP during prone spine surgery superiorly in comparison with 5 degrees. No significant complications were associated with reverse Trendelenburg positioning. Published by Elsevier Inc. C1 [Carey, Timothy W.] Irwin Army Community Hosp, Dept Orthopaed Surg, Fort Riley, KS 66442 USA. [Shaw, K. Aaron; DeVine, John G.] Dwight D Eisenhower Army Med Ctr, Dept Orthopaed Surg, Ft Gordon, GA 30905 USA. [Weber, Marissa L.] Bayne Jones Army Community Hosp, Dept Opthalmol, Fort Polk, LA 71459 USA. RP Shaw, KA (reprint author), Dwight D Eisenhower Army Med Ctr, 300 E Hosp Rd, Ft Gordon, GA 30905 USA. EM kenneth.a.shaw34.mil@mail.mil OI Shaw, Kenneth/0000-0002-3553-2889 NR 32 TC 4 Z9 4 U1 1 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1529-9430 EI 1878-1632 J9 SPINE J JI Spine Journal PD SEP PY 2014 VL 14 IS 9 BP 2118 EP 2126 DI 10.1016/j.spinee.2013.12.025 PG 9 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA AO4KA UT WOS:000341305100043 PM 24456677 ER PT J AU Thomas, TP Shih, TM AF Thomas, Thaddeus P. Shih, Tsung-Ming TI Stimulation of central A1 adenosine receptors suppresses seizure and neuropathology in a soman nerve agent seizure rat model SO TOXICOLOGY MECHANISMS AND METHODS LA English DT Article DE Adenosine agonist; anti-seizure; nerve agent; neuroprotection ID INDUCED EPILEPTIFORM ACTIVITY; TRAUMATIC BRAIN-INJURY; ACID-INDUCED SEIZURES; MOVING GUINEA-PIGS; BASAL FOREBRAIN; THERAPEUTIC HYPOTHERMIA; TIME-COURSE; A(1); MECHANISMS; SARIN AB The current regimen for treating nerve agent poisoning does not sufficiently suppress the excitotoxic activity that causes severe brain damage, especially in cases where treatment is delayed and nerve agent-induced status epilepticus develops. New therapeutic targets are required to improve survivability and minimize neuropathology after irreversible acetylcholinesterase inactivation. Earlier studies have shown that systemic delivery of adenosine agonists decreases nerve agent lethality; however, the mechanism of protection remains to be understood. The primary aim of this study was to investigate the role of central adenosine receptor (AR) stimulation in neuroprotection by directly injecting (6)-cyclopentyladenosine (CPA), an adenosine agonist specific to the A1 receptor subtype (A1R), into the brain intracerebroventricularly (ICV) in a soman seizure rat model. In addition to general A1R stimulation, we hypothesized that bilateral micro-injection of CPA into the cholinergic basal forebrain (BF) could also suppress excitotoxic activity. The results from these studies demonstrated that centrally administered adenosine agonists are anti-seizure and neuroprotective. CPA-delivered ICV prevented seizure and convulsion in 100% of the animals. Moreover, neuropathological evaluation indicated that adenosine treatments reduced brain damage from severe to minimal. Inhibition of the BF via CPA had varied results. Some animals were protected by treatment; however, others displayed similar pathology to the control. Overall, these data suggest that stimulating central ARs could be an effective target for the next generation countermeasures for nerve agent intoxication. C1 [Thomas, Thaddeus P.; Shih, Tsung-Ming] US Army, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. [Thomas, Thaddeus P.] US Army, Res Lab, Aberdeen Proving Ground, MD 21010 USA. RP Shih, TM (reprint author), US Army, Med Res Inst Chem Def, ATTN MCMR CDR P, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM tsungming.a.shih.civ@mail.mil FU ARL FX The authors report no declarations of interest. The authors alone are responsible for the content and writing of the paper. The authors also gratefully acknowledge the financial and administrative support that the ARL provided. NR 59 TC 3 Z9 3 U1 0 U2 8 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1537-6516 EI 1537-6524 J9 TOXICOL MECH METHOD JI Toxicol. Mech. Methods PD SEP PY 2014 VL 24 IS 6 BP 385 EP 395 DI 10.3109/15376516.2014.920450 PG 11 WC Toxicology SC Toxicology GA AN8BU UT WOS:000340827200003 PM 24785252 ER PT J AU Lombardini, ED Hard, GC Harshbarger, JC AF Lombardini, E. D. Hard, G. C. Harshbarger, J. C. TI Neoplasms of the Urinary Tract in Fish SO VETERINARY PATHOLOGY LA English DT Review DE fish and marine animals; wildlife; urinary tract; oncology ID TROUT SALMO-GAIRDNERI; RAINBOW-TROUT; NEPHRO-BLASTOMA; ENVIRONMENTAL CARCINOGENESIS; SPONTANEOUS NEPHROBLASTOMA; ONCORHYNCHUS-TSHAWYTSCHA; CYPRINUS-CARPIO; CHINOOK SALMON; WILMS-TUMORS; RODENT MODEL AB The veterinary literature contains scattered reports of primary tumors of the urinary tract of fish, dating back to 1906. Many of the more recent reports have been described in association with the Registry of Tumors in Lower Animals, and most of the spontaneous neoplasms of the kidney and urinary bladder are single case reports. In rare instances, such as described in nephroblastomas of Japanese eels and tubular adenomas/adenocarcinomas of Oscars, there is suggestion of a genetic predisposition of certain populations to specific renal neoplasms, environmental carcinogenesis, or potentially an unknown infectious etiology acting as a promoter. Hematopoeitic neoplasms have been infrequently described as primary to the kidney of a variety of fish species, and therefore those case reports of renal lymphoma and plasmacytic leukemia are addressed within the context of this review. C1 [Lombardini, E. D.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Harshbarger, J. C.] George Washington Univ, Med Ctr, Dept Pathol, Washington, DC 20037 USA. RP Lombardini, ED (reprint author), USAMC AFRIMS, Armed Forces Res Inst Med Sci, APO, AP 96546 USA. EM Lombardinied@afrims.org NR 88 TC 1 Z9 1 U1 0 U2 2 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0300-9858 EI 1544-2217 J9 VET PATHOL JI Vet. Pathol. PD SEP PY 2014 VL 51 IS 5 BP 1000 EP 1012 DI 10.1177/0300985813511122 PG 13 WC Pathology; Veterinary Sciences SC Pathology; Veterinary Sciences GA AN7MY UT WOS:000340785900016 PM 24318975 ER PT J AU Darling, KA Tschopp, MA Guduru, RK Yin, WH Wei, Q Kecskes, LJ AF Darling, K. A. Tschopp, M. A. Guduru, R. K. Yin, W. H. Wei, Q. Kecskes, L. J. TI Microstructure and mechanical properties of bulk nanostructured Cu-Ta alloys consolidated by equal channel angular extrusion SO ACTA MATERIALIA LA English DT Article DE Nanocrystalline alloys; Cu-Ta alloys; Equal channel angular pressing; Mechanical behavior; Dynamic compression test ID STRAIN-RATE SENSITIVITY; SHEAR PUNCH TEST; NANOCRYSTALLINE COPPER; GRAIN-SIZE; PLASTIC-DEFORMATION; THERMAL-STABILITY; ACTIVATION VOLUME; TENSILE BEHAVIOR; ULTRAFINE GRAIN; METALS AB Nanostructured Cu-Ta alloys have shown promise as high-strength nanocrystalline materials in part due to their limited grain growth at high temperatures. In the present study, Cu-Ta alloy powders, synthesized via high-energy cryogenic mechanical alloying, were consolidated into bulk nanostructured specimens using equal channel angular extrusion (ECAE) at high temperatures. Subsequent microstructure characterization indicated full consolidation, which resulted in an equiaxed grain structure for the Cu matrix along with the formation of fine Ta precipitates, the size distributions of which varied both with composition and processing temperature. Microhardness, compression and shear punch testing indicated, in some cases, an almost threefold increase in mechanical properties above that predicted by Hall-Petch estimates for pure nanocrystalline Cu. Stress relaxation tests substantiated the strain-hardening behavior and grain-size-dependent dislocation activity observed in the nanocrystalline Cu-Ta samples. Published by Elsevier Ltd. on behalf of Acta Materialia Inc. C1 [Darling, K. A.; Tschopp, M. A.; Kecskes, L. J.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Guduru, R. K.] Univ Michigan, Dept Mech Engn, Dearborn, MI 48128 USA. [Yin, W. H.; Wei, Q.] Univ N Carolina, Dept Mech Engn & Engn Sci, Charlotte, NC 28223 USA. RP Darling, KA (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM kristopher.darling.civ@mail.mil RI Wei, Qiuming/B-7579-2008; GUDURU, RAMESH KUMAR/N-8541-2016; OI GUDURU, RAMESH KUMAR/0000-0002-9570-4208; Tschopp, Mark/0000-0001-8471-5035 NR 78 TC 16 Z9 16 U1 5 U2 57 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6454 EI 1873-2453 J9 ACTA MATER JI Acta Mater. PD SEP 1 PY 2014 VL 76 BP 168 EP 185 DI 10.1016/j.actamat.2014.04.074 PG 18 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA AN1GJ UT WOS:000340330400015 ER PT J AU Galvin, JW Freedman, BA Schoenfeld, AJ Cap, AP Mok, JM AF Galvin, J. W. Freedman, B. A. Schoenfeld, A. J. Cap, A. P. Mok, J. M. TI Morbidity of early spine surgery in the multiply injured patient SO ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY LA English DT Article DE Combat spine trauma; Military casualties; Spine surgery in theater; Spine fracture; Polytrauma; Afghanistan war; Operation enduring freedom ID DAMAGE-CONTROL; CORD-INJURY; POLYTRAUMA PATIENTS; FRACTURE FIXATION; TRAUMA PATIENTS; DECOMPRESSION; IMPACT; IRAQ; STABILIZATION; COMPLICATIONS AB The optimal timing of surgery for multiply injured patients with operative spinal injuries remains unknown. The purported benefits of early intervention must be weighed against the morbidity of surgery in the early post-injury period. The performance of spine surgery in the Afghanistan theater permits analysis of the morbidity of early surgery on military casualties. The objective is to compare surgical morbidity of early spinal surgery in multiply injured patients versus stable patients. Patients were retrospectively categorized as stable or borderline unstable depending on the presence of at least one of the following: ISS > 40, ISS > 20 and chest injury, exploratory laparotomy or thoracotomy, lactate > 2.5 mEq/L, platelet < 110,000/mm(3), or > 10 U PRBCs transfused pre-operatively. Surgical morbidity, complications, and neurologic improvement between the two groups were compared retrospectively. 30 casualties underwent 31 spine surgeries during a 12-month period. 16 of 30 patients met criteria indicating a borderline unstable patient. Although there were no significant differences in the procedures performed for stable and borderline unstable patients as measured by the Surgical Invasiveness Index (7.5 vs. 6.9, p = 0.8), borderline unstable patients had significantly higher operative time (4.3 vs. 3.0 h, p = 0.01), blood loss (1,372 vs. 366 mL, p = 0.001), PRBCs transfused intra-op (3.88 vs. 0.14 U, p < 0.001), and total PRBCs transfused in theater (10.18 vs. 0.31 U, p < 0.001). The results indicate that published criteria defining a borderline unstable patient may have a role in predicting increased morbidity of early spine surgery. The perceived benefits of early intervention should be weighed against the greater risks of performing extensive spinal surgeries on multiply injured patients in the early post-injury period, especially in the setting of combat trauma. C1 [Galvin, J. W.] Madigan Army Med Ctr, Orthopaed Surg Serv, Tacoma, WA 98431 USA. [Freedman, B. A.] Landstuhl Reg Med Ctr, Spine & Neurosurg Serv, Landstuhl, Germany. [Schoenfeld, A. J.] Ann Arbor Vet Adm Hosp, Dept Orthopaed Surg, Ann Arbor, MI 48105 USA. [Cap, A. P.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Mok, J. M.] Univ Chicago, Dept Orthopaed Surg & Rehabil Med, Chicago, IL 60637 USA. RP Mok, JM (reprint author), Univ Chicago, Dept Orthopaed Surg & Rehabil Med, 5841 S Maryland Ave MC 3079, Chicago, IL 60637 USA. EM jmok@bsd.uchicago.edu OI Schoenfeld, Andrew/0000-0002-3691-1215 NR 37 TC 1 Z9 1 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0936-8051 EI 1434-3916 J9 ARCH ORTHOP TRAUM SU JI Arch. Orthop. Trauma Surg. PD SEP PY 2014 VL 134 IS 9 BP 1211 EP 1217 DI 10.1007/s00402-014-2068-7 PG 7 WC Orthopedics; Surgery SC Orthopedics; Surgery GA AN4UJ UT WOS:000340583700004 PM 25077784 ER PT J AU Wolfenstine, J Allen, JL Jow, TR Thompson, T Sakamoto, J Jo, H Choe, H AF Wolfenstine, J. Allen, J. L. Jow, T. R. Thompson, T. Sakamoto, J. Jo, H. Choe, H. TI LiCoPO4 mechanical properties evaluated by nanoindentation SO CERAMICS INTERNATIONAL LA English DT Article DE Hardness; Fracture toughness; LiCoPO4; Modulus; Olivine ID FE-SUBSTITUTED LICOPO4; FRACTURE-TOUGHNESS; ELASTIC-MODULUS; ION BATTERIES; INDENTATION; HARDNESS; ELECTRODES; INSERTION; PRESSURE; CAPACITY AB LiCoPO4 is a promising cathode material for use in high voltage Li-ion batteries. One of the problems with LiCoPO4 is limited cycle life. One possible cause for the limited cycle life of LiCoPO4 is mechanical degradation. As a consequence, the mechanical properties, elastic modulus, E, and fracture toughness, Kic, of hot-pressed dense (similar to 98%) polycrystalline (15-20 mu m) single phase LiCoPO4 were investigated. E for the hotpressed LiCoPO4 specimen is similar to 137 GPa while the E value for the LiCoPO4 specimen after annealing at 600 degrees C is 106 GPa. The fracture toughness of the hot-pressed LiCoPO4 sample is similar to 0.41 MPa m112, which increased to similar to 0.53 MPa 111112 after annealing. These low Ific values reveal that LiCoPO4 is a brittle material. It is believed that the decrease in E and increase in Kic with annealing is associated with a reduction in residual stress. Published by Elsevier Ltd and Techna Group S.r.l. C1 [Wolfenstine, J.; Allen, J. L.; Jow, T. R.] US Army Res Lab, Adelphi, MD 20783 USA. [Thompson, T.; Sakamoto, J.] Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA. [Jo, H.; Choe, H.] Kookmin Univ, Sch Adv Mat Engn, Seoul 136702, South Korea. RP Wolfenstine, J (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM jeffrey.b.wolfenstine.civ@mail.mil RI Choe, Heeman/J-4053-2013 OI Choe, Heeman/0000-0002-5908-577X FU U. S. Army Research Laboratory (ARL); Research Centers Programs through National Research Foundation (NRF) of Korea [20110001684]; Army Research Laboratory; [2012-0006680] FX JLA, TRJ and JW acknowledge support of the U. S. Army Research Laboratory (ARL). HC also acknowledges financial supports from Priority (2012-0006680) and Pioneer (20110001684) Research Centers Programs through National Research Foundation (NRF) of Korea. JS and TT acknowledge support of the Army Research Laboratory. NR 35 TC 3 Z9 3 U1 4 U2 37 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0272-8842 EI 1873-3956 J9 CERAM INT JI Ceram. Int. PD SEP PY 2014 VL 40 IS 8 BP 13673 EP 13677 DI 10.1016/j.ceramint.2014.04.122 PN B PG 5 WC Materials Science, Ceramics SC Materials Science GA AN1CW UT WOS:000340321300134 ER PT J AU Jachowski, DS Dobony, CA Coleman, LS Ford, WM Britzke, ER Rodrigue, JL AF Jachowski, David S. Dobony, Chris A. Coleman, Laci S. Ford, William M. Britzke, Eric R. Rodrigue, Jane L. TI Disease and community structure: white-nose syndrome alters spatial and temporal niche partitioning in sympatric bat species SO DIVERSITY AND DISTRIBUTIONS LA English DT Article DE Community structure; disease; Myotis; niche partitioning; spatial niche partitioning; temporal niche partitioning; white-nose syndrome ID ENDANGERED INDIANA BAT; INTERSPECIFIC COMPETITION; INSECTIVOROUS BATS; HABITAT USE; MYOTIS-LUCIFUGUS; SOCIAL CALLS; PIPISTRELLUS-PIPISTRELLUS; LASIURUS-CINEREUS; FIELD EXPERIMENTS; EPTESICUS-FUSCUS AB Aim Emerging infectious diseases present a major perturbation with apparent direct effects such as reduced population density, extirpation and/or extinction. Comparatively less is known about the potential indirect effects of disease that likely alter community structure and larger ecosystem function. Since 2006, white-nose syndrome (WNS) has resulted in the loss of over 6 million hibernating bats in eastern North America. Considerable evidence exists concerning niche partitioning in sympatric bat species in this region, and the unprecedented, rapid decline in multiple species following WNS may provide an opportunity to observe a dramatic restructuring of the bat community. Location We conducted our study at Fort Drum Army Installation in Jefferson and Lewis counties, New York, USA, where WNS first impacted extant bat species in winter 2007-2008. Methods Acoustical monitoring during 2003-2011 allowed us to test the hypothesis that spatial and temporal niche partitioning by bats was relaxed post-WNS. Results We detected nine bat species pre-and post-WNS. Activity for most bat species declined post-WNS. Dramatic post-WNS declines in activity of little brown bat (Myotis lucifugus, MYLU), formerly the most abundant bat species in the region, were associated with complex, often species-specific responses by other species that generally favoured increased spatial and temporal overlap with MYLU. Main conclusions In addition to the obvious direct effects of disease on bat populations and activity levels, our results provide evidence that disease can have cascading indirect effects on community structure. Recent occurrence of WNS in North America, combined with multiple existing stressors, is resulting in dramatic shifts in temporal and spatial niche partitioning within bat communities. These changes might influence long-term population viability of some bat species as well as broader scale ecosystem structure and function. C1 [Jachowski, David S.; Coleman, Laci S.] Virginia Polytech Inst & State Univ, Dept Fisheries & Wildlife Conservat, Blacksburg, VA 24061 USA. [Dobony, Chris A.] IMNE DRM PWE, Ft Drum Mil Installat, Nat Resources Branch, Ft Drum, NY 13602 USA. [Ford, William M.] Virginia Polytech Inst & State Univ, US Geol Survey, Virginia Cooperat Fish & Wildlife Res Unit, Blacksburg, VA 24061 USA. [Britzke, Eric R.] US Army Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Rodrigue, Jane L.] US Forest Serv, No Res Stn, Princeton, WV 24740 USA. RP Jachowski, DS (reprint author), Virginia Polytech Inst & State Univ, Dept Fisheries & Wildlife Conservat, Blacksburg, VA 24061 USA. EM djachowski@gmail.com FU Department of the Army, Fort Drum; U.S. Army Engineer and Research Development Center; U.S. Forest Service, Northern Research Station; U.S. Geological Survey, Cooperative Fish and Wildlife Research Program FX We thank R. Rainbolt for assistance throughout this project. This work was funded by financial and in-kind contributions of the Department of the Army, Fort Drum, the U.S. Army Engineer and Research Development Center, the U.S. Forest Service, Northern Research Station, and the U.S. Geological Survey, Cooperative Fish and Wildlife Research Program. NR 96 TC 6 Z9 6 U1 11 U2 124 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1366-9516 EI 1472-4642 J9 DIVERS DISTRIB JI Divers. Distrib. PD SEP PY 2014 VL 20 IS 9 BP 1002 EP 1015 DI 10.1111/ddi.12192 PG 14 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA AN2OX UT WOS:000340426300002 ER PT J AU Kurylo, DD Larkin, GB Waxman, R Bukhari, F AF Kurylo, Daniel D. Larkin, Gabriella Brick Waxman, Richard Bukhari, Farhan TI Speed of perceptual grouping in acquired brain injury SO EXPERIMENTAL BRAIN RESEARCH LA English DT Article DE Speed of information processing; Gestalt; Perceptual organization, white matter connections ID DIFFUSE AXONAL INJURY; ALZHEIMERS-DISEASE; PROCESSING SPEED; VISUAL-CORTEX; INFORMATION; ORGANIZATION; SCHIZOPHRENIA; STROKE; SLOWNESS AB Evidence exists that damage to white matter connections may contribute to reduced speed of information processing in traumatic brain injury and stroke. Damage to such axonal projections suggests a particular vulnerability to functions requiring integration across cortical sites. To test this prediction, measurements were made of perceptual grouping, which requires integration of stimulus components. A group of traumatic brain injury and cerebral vascular accident patients and a group of age-matched healthy control subjects viewed arrays of dots and indicated the pattern into which stimuli were perceptually grouped. Psychophysical measurements were made of perceptual grouping as well as processing speed. The patient group showed elevated grouping thresholds as well as extended processing time. In addition, most patients showed progressive slowing of processing speed across levels of difficulty, suggesting reduced resources to accommodate increased demands on grouping. These results support the prediction that brain injury results in a particular vulnerability to functions requiring integration of information across the cortex, which may result from dysfunction of long-range axonal connection. C1 [Kurylo, Daniel D.] CUNY Brooklyn Coll, Dept Psychol, Brooklyn, NY 11210 USA. [Larkin, Gabriella Brick] US Army Res Lab, Human Res & Engn Directorate, Picatinny Arsenal, NJ 07806 USA. [Waxman, Richard] Touro Coll, Grad Sch Psychol, New York, NY 10010 USA. [Bukhari, Farhan] CUNY, Grad Ctr, Dept Comp Sci, New York, NY 10016 USA. RP Kurylo, DD (reprint author), CUNY Brooklyn Coll, Dept Psychol, 2900 Bedford Ave, Brooklyn, NY 11210 USA. EM dkurylo@brooklyn.cuny.edu NR 34 TC 1 Z9 1 U1 0 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0014-4819 EI 1432-1106 J9 EXP BRAIN RES JI Exp. Brain Res. PD SEP PY 2014 VL 232 IS 9 BP 2899 EP 2905 DI 10.1007/s00221-014-3970-5 PG 7 WC Neurosciences SC Neurosciences & Neurology GA AN4KO UT WOS:000340556800019 PM 24820289 ER PT J AU Harper, NG Russell, EM Wilken, JM Neptune, RR AF Harper, Nicole G. Russell, Elizabeth M. Wilken, Jason M. Neptune, Richard R. TI Selective Laser Sintered Versus Carbon Fiber Passive-Dynamic Ankle-Foot Orthoses: A Comparison of Patient Walking Performance SO JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME LA English DT Article ID JOINT COORDINATE SYSTEM; GAIT ABNORMALITIES; NERVE PARALYSIS; MUSCLE-ACTIVITY; KINEMATIC DATA; DROP-FOOT; CHILDREN; HEMIPLEGIA; CONFIGURATIONS; CUSTOMIZATION AB Selective laser sintering (SLS) is a well-suited additive manufacturing technique for generating subject-specific passive-dynamic ankle-foot orthoses (PD-AFOs). However, the mechanical properties of SLS PD-AFOs may differ from those of commonly prescribed carbon fiber (CF) PD-AFOs. Therefore, the goal of this study was to determine if biomechanical measures during gait differ between CF and stiffness-matched SLS PD-AFOs. Subject-specific SLS PD-AFOs were manufactured for ten subjects with unilateral lower-limb impairments. Minimal differences in gait performance occurred when subjects used the SLS versus CF PD-AFOs. These results support the use of SLS PD-AFOs to study the effects of altering design characteristics on gait performance. C1 [Harper, Nicole G.; Neptune, Richard R.] Univ Texas Austin, Dept Mech Engn, Austin, TX 78712 USA. [Russell, Elizabeth M.; Wilken, Jason M.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ctr Intrepid, Ft Sam Houston, TX 78234 USA. RP Neptune, RR (reprint author), Univ Texas Austin, Dept Mech Engn, Austin, TX 78712 USA. EM nicole.harper@utexas.edu; elizabeth.m.russell34.ctr@mail.mil; Jason.m.wilken.civ@mail.mil; rneptune@mail.utexas.edu OI Russell Esposito, Elizabeth/0000-0001-5321-0333; Wilken, Jason/0000-0002-5556-7667 FU National Science Foundation Graduate Research Fellowship [DGE-1110007]; Center for Rehabilitation Sciences Research FX This study was supported in part by a National Science Foundation Graduate Research Fellowship (DGE-1110007) and a research grant from the Center for Rehabilitation Sciences Research. The contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Science Foundation. The view(s) expressed herein are those of the author(s) and do not reflect the official policy or position of Brooke Army Medical Center, the U. S. Army Medical Department, the U.S. Army Office of the Surgeon General, the Department of the Army, Department of Defense or the U.S. Government. NR 42 TC 6 Z9 6 U1 2 U2 27 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0148-0731 EI 1528-8951 J9 J BIOMECH ENG-T ASME JI J. Biomech. Eng.-Trans. ASME PD SEP PY 2014 VL 136 IS 9 AR 091001 DI 10.1115/1.4027755 PG 7 WC Biophysics; Engineering, Biomedical SC Biophysics; Engineering GA AN5GC UT WOS:000340617700001 PM 24870600 ER PT J AU Lin, Y Wang, D Donetsky, D Belenky, G Hier, H Sarney, WL Svensson, SP AF Lin, Y. Wang, D. Donetsky, D. Belenky, G. Hier, H. Sarney, W. L. Svensson, S. P. TI Minority Carrier Lifetime in Beryllium-Doped InAs/InAsSb Strained Layer Superlattices SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE MBE; SLS; LWIR photodetector; InAs/InAsSb; carrier lifetime AB Minority carrier lifetimes in undoped and Beryllium-doped Type-2 Ga-free, InAs/InAsSb strained layer superlattices (SLS) with energy gaps as low as 0.165 eV were determined from photoluminescence kinetics. The minority carrier lifetime of 450 ns at 77 K in the undoped SLS confirms a high material quality. In similarly-grown structures that were p-doped to N (A) = 6 x 10(16) and 3 x 10(17) cm(-3), electron lifetimes of tau (n) = 45 ns and 8 ns were measured. The 6 x 10(16) cm(-3) doping level is a factor of 6 greater than the typical background doping level in long-wave infrared (LWIR) Ga-containing InAs/GaSb SLS with similar bandgap and electron lifetime. This suggests that LWIR photodetectors with InAs/InAsSb SLS absorbers can be designed with smaller minority carrier concentrations and diffusion dark current densities. A relatively slow decrease of the lifetime with doping suggests a minor role of Auger recombination in the studied Ga-free SLS at T = 77 K with p-doping up to mid-10(17) cm(-3) level. C1 [Lin, Y.; Wang, D.; Donetsky, D.; Belenky, G.] SUNY Stony Brook, Stony Brook, NY 11794 USA. [Hier, H.; Sarney, W. L.; Svensson, S. P.] Army Res Lab, Adelphi, MD 20783 USA. RP Lin, Y (reprint author), SUNY Stony Brook, Stony Brook, NY 11794 USA. EM youxilin7@gmail.com OI LIN, YOUXI/0000-0002-9092-2302 FU Army Research Office [W911NF1110109, W911NF1220057]; National Science Foundation [DMR1160843] FX The work was supported by Army Research Office (Grants W911NF1110109 and W911NF1220057) and by National Science Foundation (Grant DMR1160843). NR 21 TC 3 Z9 3 U1 3 U2 43 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD SEP PY 2014 VL 43 IS 9 BP 3184 EP 3190 DI 10.1007/s11664-014-3239-6 PG 7 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA AN1SJ UT WOS:000340363600017 ER PT J AU Sun, YM Li, YZ AF Sun, Yongmin Li, Yuanzhang TI Alternative Households, Structural Changes, and Cognitive Development of Infants and Toddlers SO JOURNAL OF FAMILY ISSUES LA English DT Article DE cognitive development; early childhood; infancy; family structure; family instability ID FAMILY-STRUCTURE; ACADEMIC-PERFORMANCE; ECONOMIC HARDSHIP; MIDDLE CHILDHOOD; YOUNG-CHILDREN; COHABITATION; GRANDPARENTS; TRANSITIONS; INSTABILITY; ATTACHMENT AB Using panel data from 8,650 infants in the first two waves of the Early Childhood Longitudinal Study-Birth Cohort, the current study found that the negative effects of alternative families on children's cognitive development started to emerge when children were as young as 9 months of age. Meanwhile, coresidence with grandparents was not disadvantageous and, in some cases, even beneficial for the cognitive development of 9-month-old infants. Our analyses also found that some forms of family instability were actually more beneficial to children's cognitive growth between 9 months and 2 years of age than all types of stable family structures. However, continuous coresidence with grandparents did not further benefit children's cognitive growth rate. Overall, the analyses found evidence for the resource deprivation and attachment perspectives but cast some doubt on instability theory. C1 [Sun, Yongmin] Ohio State Univ, Mansfield, OH 44906 USA. [Li, Yuanzhang] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Sun, YM (reprint author), Ohio State Univ, 1760 Univ Dr, Mansfield, OH 44906 USA. EM sun.84@osu.edu OI Li, Yuanzhang/0000-0001-8872-4430 NR 50 TC 1 Z9 1 U1 2 U2 36 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0192-513X EI 1552-5481 J9 J FAM ISSUES JI J. Fam. Issues PD SEP PY 2014 VL 35 IS 11 BP 1440 EP 1472 DI 10.1177/0192513X13495399 PG 33 WC Family Studies SC Family Studies GA AN4JR UT WOS:000340554400002 ER PT J AU Gilman, SE Bromet, EJ Cox, KL Colpe, LJ Fullerton, CS Gruber, MJ Heeringa, SG Lewandowski-Romps, L Millikan-Bell, AM Naifeh, JA Nock, MK Petukhova, MV Sampson, NA Schoenbaum, M Stein, MB Ursano, RJ Wessely, S Zaslavsky, AM Kessler, RC AF Gilman, S. E. Bromet, E. J. Cox, K. L. Colpe, L. J. Fullerton, C. S. Gruber, M. J. Heeringa, S. G. Lewandowski-Romps, L. Millikan-Bell, A. M. Naifeh, J. A. Nock, M. K. Petukhova, M. V. Sampson, N. A. Schoenbaum, M. Stein, M. B. Ursano, R. J. Wessely, S. Zaslavsky, A. M. Kessler, R. C. CA Army STARRS Collaborators TI Sociodemographic and career history predictors of suicide mortality in the United States Army 2004-2009 SO PSYCHOLOGICAL MEDICINE LA English DT Article DE Army; Army STARRS; epidemiology; military; risk factors; suicide ID ACTIVE-DUTY PERSONNEL; US MILITARY PERSONNEL; MENTAL-HEALTH; RISK-FACTORS; LIFE-COURSE; DEPLOYMENT; COMBAT; IRAQ; BEHAVIOR; GENDER AB Background. The US Army suicide rate has increased sharply in recent years. Identifying significant predictors of Army suicides in Army and Department of Defense (DoD) administrative records might help focus prevention efforts and guide intervention content. Previous studies of administrative data, although documenting significant predictors, were based on limited samples and models. A career history perspective is used here to develop more textured models. Method. The analysis was carried out as part of the Historical Administrative Data Study (HADS) of the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS). De-identified data were combined across numerous Army and DoD administrative data systems for all Regular Army soldiers on active duty in 2004-2009. Multivariate associations of sociodemographics and Army career variables with suicide were examined in subgroups defined by time in service, rank and deployment history. Results. Several novel results were found that could have intervention implications. The most notable of these were significantly elevated suicide rates (69.6-80.0 suicides per 100000 person-years compared with 18.5 suicides per 100000 person-years in the total Army) among enlisted soldiers deployed either during their first year of service or with less than expected (based on time in service) junior enlisted rank; a substantially greater rise in suicide among women than men during deployment; and a protective effect of marriage against suicide only during deployment. Conclusions. A career history approach produces several actionable insights missed in less textured analyses of administrative data predictors. Expansion of analyses to a richer set of predictors might help refine understanding of intervention implications. C1 [Gilman, S. E.] Harvard Univ, Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA 02115 USA. [Gilman, S. E.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Bromet, E. J.] Stony Brook Sch Med, Dept Psychiat & Behav Sci, Stony Brook, NY USA. [Cox, K. L.; Millikan-Bell, A. M.] US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA. [Colpe, L. J.] NIMH, Div Serv & Intervent Res, Bethesda, MD 20892 USA. [Fullerton, C. S.; Naifeh, J. A.; Ursano, R. J.] Uniformed Serv Univ Sch Med, Ctr Study Traumat Stress, Dept Psychiat, Bethesda, MD USA. [Gruber, M. J.; Petukhova, M. V.; Sampson, N. A.; Zaslavsky, A. M.; Kessler, R. C.] Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 USA. [Heeringa, S. G.; Lewandowski-Romps, L.] Univ Michigan, Inst Social Res, Ann Arbor, MI USA. [Nock, M. K.] Harvard Univ, Dept Psychol, Cambridge, MA 02138 USA. [Schoenbaum, M.] NIMH, Off Sci Policy Planning & Commun, Bethesda, MD 20892 USA. [Stein, M. B.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA. [Stein, M. B.] Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA. [Stein, M. B.] VA San Diego Healthcare Syst, San Diego, CA USA. [Wessely, S.] Kings Coll London, Kings Ctr Mil Hlth Res, London WC2R 2LS, England. RP Kessler, RC (reprint author), Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 USA. EM ncs@hcp.med.harvard.edu RI Gilman, Stephen/E-7632-2010; Wessely, Simon/A-8713-2008 OI Gilman, Stephen/0000-0002-8331-6419; FU Department of the Army; US Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health (NIH/NIMH) [U01MH087981] FX The study received the following financial support. Army STARRS was sponsored by the Department of the Army and funded under cooperative agreement number U01MH087981 with the US Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health (NIH/NIMH). The contents are solely the responsibility of the authors and do not necessarily represent the views of the Department of Health and Human Services, NIMH, the Department of the Army, or the DoD. NR 47 TC 17 Z9 17 U1 3 U2 7 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0033-2917 EI 1469-8978 J9 PSYCHOL MED JI Psychol. Med. PD SEP PY 2014 VL 44 IS 12 BP 2579 EP 2592 DI 10.1017/S003329171400018X PG 14 WC Psychology, Clinical; Psychiatry; Psychology SC Psychology; Psychiatry GA AN2GV UT WOS:000340403400012 PM 25055175 ER PT J AU Trumbo, BA Ahmann, ML Renholds, JF Brown, RS Colotelo, AH Deng, ZD AF Trumbo, Bradly A. Ahmann, Martin L. Renholds, Jon F. Brown, Richard S. Colotelo, Alison H. Deng, Z. D. TI Improving hydroturbine pressures to enhance salmon passage survival and recovery SO REVIEWS IN FISH BIOLOGY AND FISHERIES LA English DT Article DE Hydroturbine; Turbine passage; Turbine design; Salmon; Survival; Barotrauma ID JUVENILE CHINOOK SALMON; ACOUSTIC TELEMETRY SYSTEM; HYDRO-TURBINE PASSAGE; NEUTRALLY BUOYANT; TRANSMITTERS; BAROTRAUMA; SMOLTS; INSTRUMENTATION; MORTALITY; TRACKING AB Barotrauma caused by rapid decompression during hydroturbine (turbine) passage may occur as fish move through the low pressure region below the turbine runner. This scenario is of particular concern in North American rivers with populations of ESA-listed salmon. The US Army Corps of Engineers (USACE) and the Pacific Northwest National Laboratory released Sensor Fish into lower Snake and Columbia River turbines to determine the magnitude and rate of pressure change fish might experience. Recorded pressures were applied to simulated turbine passage (STP) in laboratory studies to determine the effect of rapid decompression on juvenile Chinook salmon. These STP studies have increased our understanding of how pressure effects fish passing through turbines and suggest that the ratio of pressure change [acclimation pressure (the depth upstream of the dam where fish are neutrally buoyant) divided by nadir pressure (lowest pressure)] is highly predictive in determining the effect on smolt survival. However, uncertainty remains in smolt acclimation depth prior to entering turbine intakes at hydroelectric facilities. The USACE continues to make progress on salmon survival and recovery efforts through continued research and by applying pressure study results to turbine design. Designing new turbines with higher nadir pressure criteria is likely to provide safer fish passage for all salmonid species experiencing turbine passage. C1 [Trumbo, Bradly A.; Ahmann, Martin L.; Renholds, Jon F.] US Army Corps Engineers, Walla Walla, WA 99362 USA. [Brown, Richard S.; Colotelo, Alison H.; Deng, Z. D.] Pacific NW Natl Lab, Richland, WA 99352 USA. RP Trumbo, BA (reprint author), US Army Corps Engineers, 201N Third Ave, Walla Walla, WA 99362 USA. EM bradly.a.trumbo@usace.army.mil RI Deng, Daniel/A-9536-2011 OI Deng, Daniel/0000-0002-8300-8766 NR 52 TC 6 Z9 6 U1 9 U2 45 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0960-3166 EI 1573-5184 J9 REV FISH BIOL FISHER JI Rev. Fish. Biol. Fish. PD SEP PY 2014 VL 24 IS 3 SI SI BP 955 EP 965 DI 10.1007/s11160-013-9340-8 PG 11 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA AN2ZS UT WOS:000340455200015 ER PT J AU Karl, JP Cheatham, RA Das, SK Hyatt, RR Gilhooly, CH Pittas, AG Lieberman, HR Lerner, D Roberts, SB Saltzman, E AF Karl, J. Philip Cheatham, Rachel A. Das, Sai Krupa Hyatt, Raymond R. Gilhooly, Cheryl H. Pittas, Anastassios G. Lieberman, Harris R. Lerner, Debra Roberts, Susan B. Saltzman, Edward TI Effect of glycemic load on eating behavior self-efficacy during weight loss SO APPETITE LA English DT Article DE Energy restriction; Glycemic index; Weight maintenance; Weight regain; Weight self-efficacy ID DOUBLY LABELED WATER; MIDDLE-AGED WOMEN; LOSS MAINTENANCE; OBESE WOMEN; ENERGY-EXPENDITURE; DIETARY ADHERENCE; OVERWEIGHT MEN; PREDICTORS; HEALTH; REDUCTION AB High eating behavior self-efficacy may contribute to successful weight loss. Diet interventions that maximize eating behavior self-efficacy may therefore improve weight loss outcomes. However, data on the effect of diet composition on eating behavior self-efficacy are sparse. To determine the effects of dietary glycemic load (GL) on eating behavior self-efficacy during weight loss, body weight and eating behavior self-efficacy were measured every six months in overweight adults participating in a 12-mo randomized trial testing energy-restricted diets differing in GL. All food was provided during the first six months and self-selected thereafter. Total mean weight loss did not differ between groups, and GL-level had no significant effect on eating behavior self-efficacy. In the combined cohort, individuals losing the most weight reported improvements in eating behavior self-efficacy, whereas those achieving less weight loss reported decrements in eating behavior self-efficacy. Decrements in eating behavior self-efficacy were associated with subsequent weight regain when diets were self-selected. While GL does not appear to influence eating behavior self-efficacy, lesser amounts of weight loss on provided-food energy restricted diets may deter successful maintenance of weight loss by attenuating improvements in eating behavior self-efficacy. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Karl, J. Philip; Cheatham, Rachel A.; Das, Sai Krupa; Hyatt, Raymond R.; Gilhooly, Cheryl H.; Roberts, Susan B.; Saltzman, Edward] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA. [Pittas, Anastassios G.] Tufts Med Ctr, Div Endocrinol Diabet & Metab, Boston, MA 02111 USA. [Lieberman, Harris R.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. [Lerner, Debra] Tufts Med Ctr, Inst Clin Res & Hlth Policy Studies, Boston, MA 02111 USA. RP Saltzman, E (reprint author), Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, 711 Washington St, Boston, MA 02111 USA. EM edward.saltzman@tufts.edu RI Biguzzi, Felipe/E-4724-2015; OI Karl, J. Philip/0000-0002-5871-2241 FU U.S. Department of Agriculture, Agricultural Research Service [58-1950-7-707]; National Institutes of Health [U01-AG20480]; U.S. Department of Agriculture from the National Institutes of Diabetes and Digestive and Kidney Diseases [58-1950-4-401, K23 DK61506]; Boston Nutrition Obesity Research Center (BONRC) [H150001]; Science, Mathematics, and Research Transformation Defense Education Program; NIH [DK62032-11] FX The study is based upon work supported by the U.S. Department of Agriculture, Agricultural Research Service, under agreement No. 58-1950-7-707. Any opinions, findings, conclusion, or recommendations expressed in this publication are those of the authors and do not necessarily reflect the view of the U.S. Department of Agriculture, the U.S. Army, or the U.S. Department of Defense. The Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy trial-phase I study was supported by National Institutes of Health grant U01-AG20480, the U.S. Department of Agriculture under agreement No. 58-1950-4-401, K23 DK61506 from the National Institutes of Diabetes and Digestive and Kidney Diseases, and Boston Nutrition Obesity Research Center (BONRC) H150001. JPK was supported by the Science, Mathematics, and Research Transformation Defense Education Program. RAC was supported by a NIH T32 grant (#DK62032-11). We wish to thank the study volunteers and the staff of the Metabolic Research Unit for their dedication to this project. U.S. National Institutes of Health clinicaltrials.gov identifier: NCT00099099. Conflict of interest: No authors report a conflict of interest. NR 47 TC 1 Z9 1 U1 1 U2 13 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0195-6663 EI 1095-8304 J9 APPETITE JI Appetite PD SEP 1 PY 2014 VL 80 BP 204 EP 211 DI 10.1016/j.appet.2014.05.017 PG 8 WC Behavioral Sciences; Nutrition & Dietetics SC Behavioral Sciences; Nutrition & Dietetics GA AN0XS UT WOS:000340307900028 PM 24859114 ER PT J AU Keebler, JR Dietz, AS Lazzara, EH Benishek, LE Almeida, SA Toor, PA King, HB Salas, E AF Keebler, Joseph R. Dietz, Aaron S. Lazzara, Elizabeth H. Benishek, Lauren E. Almeida, Sandra A. Toor, Phyllis A. King, Heidi B. Salas, Eduardo TI Validation of a teamwork perceptions measure to increase patient safety SO BMJ QUALITY & SAFETY LA English DT Article ID CARE; WORK AB Background TeamSTEPPS (Team Strategies and Tools to Enhance Performance and Patient Safety) is a team-training intervention which shows promise in aiding the mitigation of medical errors. This article examines the construct validity of the TeamSTEPPS Teamwork Perceptions Questionnaire (T-TPQ), a self-report survey that examines multiple dimensions of perceptions of teamwork within healthcare settings. Method Using survey-based methods, 1700 multidisciplinary healthcare professionals and support staff were measured on their perceptions of teamwork. Confirmatory factor analysis was conducted to examine the relationship between the five TeamSTEPPS dimensions: Leadership, Mutual Support, Situation Monitoring, Communication, and Team Structure. Results The analysis indicated that the T-TPQ measure is more reliable than previously thought (Cronbach's alpha=0.978). Further, our final tested model showed a good fit with the data (x(2) (df) 3601.27 (546), p<0.0001, Tucker-Lewis Index (TLI)=0.942, Comparative fit index (CFI)=0.947, root mean square error of approximation (RMSEA)=0.057), indicating that the measure appears to have construct validity. Further, all dimensions correlated with one another, but were shown to be independent constructs. Conclusions The T-TPQ is a construct-valid instrument for measuring perceptions of teamwork. This has beneficial implications for patient safety and future research that studies medical teamwork. C1 [Keebler, Joseph R.; Lazzara, Elizabeth H.] Wichita State Univ, Wichita, KS USA. [Dietz, Aaron S.; Benishek, Lauren E.; Salas, Eduardo] Univ Cent Florida, Inst Simulat & Training, Orlando, FL 32826 USA. [Dietz, Aaron S.; Benishek, Lauren E.; Salas, Eduardo] Univ Cent Florida, Dept Psychol, Orlando, FL 32826 USA. [Lazzara, Elizabeth H.] Univ Kansas, Sch Med Wichita, Lawrence, KS 66045 USA. [Almeida, Sandra A.] US Army Med Command, Army Patient Safety Program, Ft Sam Houston, TX USA. [Toor, Phyllis A.; King, Heidi B.] US Dept Def, Patient Safety Program, Def Hlth Agcy, Falls Church, VA USA. RP Salas, E (reprint author), Univ Cent Florida, Inst Simulat & Training, 3100 Technol Pkwy, Orlando, FL 32826 USA. EM esalas@ist.ucf.edu FU Booz Allen Hamilton [W81XWH-08-D-0025, 0015] FX This publication was prepared by Booz Allen Hamilton under contract to TRICARE Management Activity, Department of Defense (DoD) Contract No W81XWH-08-D-0025, Task Order No 0015. The views herein are those of the authors and are not to be construed as official or as reflecting the views of TRICARE Management Activity or the Department of Defense. NR 25 TC 9 Z9 10 U1 1 U2 25 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 2044-5415 EI 2044-5423 J9 BMJ QUAL SAF JI BMJ Qual. Saf. PD SEP PY 2014 VL 23 IS 9 BP 718 EP 726 DI 10.1136/bmjqs-2013-001942 PG 9 WC Health Care Sciences & Services; Health Policy & Services SC Health Care Sciences & Services GA AN0AR UT WOS:000340244000005 PM 24652512 ER PT J AU Loyd, DR Murphy, AZ AF Loyd, Dayna R. Murphy, Anne Z. TI The neuroanatomy of sexual dimorphism in opioid analgesia SO EXPERIMENTAL NEUROLOGY LA English DT Review DE Pain; Periaqueductal gray; Morphine; Mu opioid receptor ID VENTROLATERAL PERIAQUEDUCTAL GRAY; ROSTRAL VENTROMEDIAL MEDULLA; STIMULATION-PRODUCED ANALGESIA; IRRITABLE-BOWEL-SYNDROME; ESTROGEN-RECEPTOR-ALPHA; NUCLEUS RAPHE MAGNUS; MORPHINE ANTINOCICEPTION; GENDER-DIFFERENCES; PAIN-CONTROL; MALE-RAT AB The influence of sex has been neglected in clinical studies on pain and analgesia, with the vast majority of research conducted exclusively in males. However, both preclinical and clinical studies indicate that males and females differ in both the anatomical and physiological composition of central nervous system circuits that are involved in pain processing and analgesia. These differences influence not only the response to noxious stimuli, but also the ability of pharmacological agents to modify this response. Morphine is the most widely prescribed opiate for the alleviation of persistent pain in the clinic; however, it is becoming increasingly clear that morphine is less potent in women compared to men. This review highlights recent research identifying neuroanatomical and physiological dimorphisms underlying sex differences in pain and opioid analgesia, focusing on the endogenous descending pain modulatory circuit. Published by Elsevier Inc. C1 [Loyd, Dayna R.] US Army, Inst Surg Res, Pain Management Res Area, Ft Sam Houston, TX 78234 USA. [Murphy, Anne Z.] Georgia State Univ, Inst Neurosci, Atlanta, GA 30303 USA. RP Murphy, AZ (reprint author), Georgia State Univ, Inst Neurosci, POB 5030, Atlanta, GA 30302 USA. EM amurphy@gsu.edu OI Averitt, Dayna/0000-0001-8345-4988; Murphy, Anne/0000-0003-2889-503X FU NIDA NIH HHS [R01 DA016272] NR 93 TC 13 Z9 13 U1 0 U2 12 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0014-4886 EI 1090-2430 J9 EXP NEUROL JI Exp. Neurol. PD SEP PY 2014 VL 259 SI SI BP 57 EP 63 DI 10.1016/j.expneurol.2014.04.004 PG 7 WC Neurosciences SC Neurosciences & Neurology GA AN1NW UT WOS:000340351600008 PM 24731947 ER PT J AU Ferguson, JB Kaptay, G Schultz, BF Rohatgi, PK Cho, K Kim, CS AF Ferguson, J. B. Kaptay, George Schultz, Benjamin F. Rohatgi, Pradeep K. Cho, Kyu Kim, Chang-Soo TI Brownian Motion Effects on Particle Pushing and Engulfment During Solidification in Metal-Matrix Composites SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE LA English DT Article ID SOLID-LIQUID INTERFACE; SOLID/LIQUID INTERFACE; MECHANICAL-PROPERTIES; NANOCOMPOSITES; AL2O3; BEHAVIOR; MICROSTRUCTURE; FRONT AB Particle pushing and/or engulfment by the moving solidification front (SF) is important for the uniform distribution of reinforcement particles in metal-matrix composites (MMCs) synthesized from solidification processing, which can lead to a substantial increase in the strength of the composite materials. Previous theoretical models describing the interactions between particle and moving SF predict that large particles will be engulfed by SF while smaller particles including nanoparticles (NPs) will be pushed by it. However, there is evidence from metal-matrix nanocomposites (MMNCs) that NPs can sometimes be engulfed and distributed throughout the material rather than pushed and concentrated in the last regions to solidify. To address this disparity, in this work, an analytical model has been developed to account for Brownian motion effects. Computer simulations employing this model over a range of the SF geometries and time steps demonstrate that NPs are often engulfed rather than pushed. Based on our results, two distinct capture mechanisms were identified: (i) when a high random velocity is imparted to the particle by Brownian motion, large jumps allow the particle to overcome the repulsion of the SF, and (ii) when the net force acting on the particle is insufficient, the particle is not accelerated to a velocity high enough to outrun the advancing SF. This manuscript will quantitatively show the effect of particle size on the steady state or critical velocity of the SF when Brownian motion are taken into consideration. The statistical results incorporating the effects of Brownian motion based on the Al/Al2O3 MMNC system clearly show that ultrafine particles can be captured by the moving SF, which cannot be predicted by any of classical deterministic treatments. C1 [Ferguson, J. B.; Schultz, Benjamin F.; Rohatgi, Pradeep K.; Kim, Chang-Soo] Univ Wisconsin, Mat Sci & Engn Dept, Milwaukee, WI 53211 USA. [Kaptay, George] Univ Miskolc, Dept Nanotechnol, H-3515 Miskolc, Hungary. [Cho, Kyu] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Kim, CS (reprint author), Univ Wisconsin, Mat Sci & Engn Dept, 3200 N Cramer St, Milwaukee, WI 53211 USA. EM kimcs@uwm.edu RI Kaptay, George/L-9163-2015 OI Kaptay, George/0000-0003-4419-142X FU U.S. Army Research Laboratory [W911NF-08-2-0014] FX The authors wish to thank Dr. Robert T. McSweeney and Dr. Dev Venugopalan for their review and suggestions. This material is based upon work supported by the U.S. Army Research Laboratory under Cooperative Agreement No. W911NF-08-2-0014. The views, opinions, and conclusions made in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 28 TC 5 Z9 5 U1 2 U2 20 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1073-5623 EI 1543-1940 J9 METALL MATER TRANS A JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci. PD SEP PY 2014 VL 45A IS 10 BP 4635 EP 4645 DI 10.1007/s11661-014-2379-x PG 11 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA AM5HP UT WOS:000339888100045 ER PT J AU Gallagher, SP Ferreira, J Lang, E Holloway, W Wright, DW AF Gallagher, Sean P. Ferreira, Joe Lang, Emily Holloway, Wendy Wright, David W. TI Investigation of the relationship between physical habitat and salmonid abundance in two coastal northern California streams SO CALIFORNIA FISH AND GAME LA English DT Article DE Coho salmon; habitat relationships; large wood; Oncorhynchus kisutch; Oncorhynchus mykiss; restoration; steelhead trout AB Understanding the relationship between fish abundance and stream habitat variables is critical to designing and implementing effective freshwater habitat restoration projects for coho salmon (Oncorhynchus kisutch) and other anadromous salmonids. In this study, we investigated the relationship between summer coho salmon and steelhead trout (O. mykiss) parr abundance and physical stream habitat variables in Caspar and Pudding creeks in Mendocino County, California. Relationships between summer habitat and juvenile abundance were investigated using a stratified random experimental design. Our hypothesis was that one or more of the habitat unit types and variables examined would be associated with salmonid abundance. Habitat differences were examined between the two streams, and we tested our hypotheses regarding habitat variables and salmon id abundance using a variety of statistical tools that included two-way ANOVA, factor analysis, and negative binomial regression modeling. The results indicated that juvenile coho salmon abundance was positively (proportionally) associated with slow water, water volume, and dry large-wood abundance, and negatively associated with fast-water habitat variables. Young-of-the-year steelhead trout were positively associated with water volume and dry large-wood and negatively (or inversely) associated with overhead vegetation and fast water habitats. Older age steelhead abundance was positively associated with slow water, water volume; cover habitat formed by wet and dry wood, and undercut banks. We discuss our findings relative to the use of large wood in anadromous salmonid habitat recovery programs in California coastal watersheds. C1 [Gallagher, Sean P.] Calif Dept Fish & Wildlife, 32330 North Harbor Dr, Ft Bragg, CA 95437 USA. [Ferreira, Joe] Calif Dept Fish & Wildlife, Sacramento, CA 95822 USA. [Lang, Emily; Wright, David W.] Campbell Global Management LLC, Ft Bragg, CA 95437 USA. [Holloway, Wendy] Pacific States Marine Fisheries Commiss, Ft Bragg, CA 95437 USA. RP Gallagher, SP (reprint author), Calif Dept Fish & Wildlife, 32330 North Harbor Dr, Ft Bragg, CA 95437 USA. EM sean.gallagher@wildlife.ca.gov FU California Department of Fish and Wildlife's Fisheries Restoration Grant Program [P1210304] FX This work was funded by the California Department of Fish and Wildlife's Fisheries Restoration Grant Program (Grant P1210304). Research on live fish followed appropriate guidelines required under the Endangered Species Act Section 10 process (Permit number 10093) and CDFW policies. We thank S. Allen, L. Bolton, and D. Porter for administrative support and C. Chavez, W. Glen, K. Jordan, M. Lubejko, A. McClarry, G. McClarry, L. Smith, and B. Storms, for long hours collecting field data. We thank K. Shaffer and R. Titus for providing useful comments that greatly improved the manuscript. NR 53 TC 0 Z9 0 U1 6 U2 13 PU CALIFORNIA FISH AND GAME EDITOR PI SACRAMENTO PA 1416 NINTH ST, SACRAMENTO, CA 95814 USA SN 0008-1078 J9 CALIF FISH GAME JI Calif. Fish Game PD FAL PY 2014 VL 100 IS 4 BP 683 EP 702 PG 20 WC Fisheries; Zoology SC Fisheries; Zoology GA V41VU UT WOS:000209574500010 ER PT J AU Zarras, P Miller, CE Webber, C Anderson, N Stenger-Smith, JD AF Zarras, Peter Miller, Christopher E. Webber, Cindy Anderson, Nicole Stenger-Smith, John D. TI Laboratory and Field Studies of Poly(2,5-bis(N-methyl-N-hexylamino)phenylene vinylene) (BAM-PPV): A Potential Wash Primer Replacement for Army Military Vehicles SO COATINGS LA English DT Article DE poly(2,5-bis(N-methyl-N-hexylamino)phenylene vinylene (BAM-PPV); wash primer; adhesion; corrosion-inhibiting; hexavalent chromium (Cr(VI)); grit blasting; field studies AB In this study, an electroactive polymer (EAP), poly(2,5-bis(N-methyl-N-hexylamino) phenylene vinylene) (BAM-PPV), was tested as an alternative to current hexavalent chromium (Cr(VI))-based Army wash primers. BAM-PPV was tested in both laboratory and field studies to determine its adhesive and corrosion-inhibiting properties when applied to steel and aluminum alloys. The Army Research Laboratory (ARL) tests showed that BAM-PPV combined with an epoxy primer and the Army chemical agent-resistant coating (CARC) topcoat met Army performance requirements for military coatings. After successful laboratory testing, the BAM-PPV was then field tested for one year at the Aberdeen Test Center (ATC). This field testing showed that BAM-PPV incorporated into the Army military coating survived with no delamination of the coating and only minor corrosion on the chip sites. C1 [Zarras, Peter; Webber, Cindy; Anderson, Nicole; Stenger-Smith, John D.] NAWCWD, Polymer Sci & Engn Branch, Code 4L4200D,1900 N Knox Rd,Stop 6303, China Lake, CA 93555 USA. [Miller, Christopher E.] ARSRD ARL WM SG, Coatings & Corros, Army Res Lab, Bldg 4600, Aberdeen Proving Ground, MD 21005 USA. RP Zarras, P (reprint author), NAWCWD, Polymer Sci & Engn Branch, Code 4L4200D,1900 N Knox Rd,Stop 6303, China Lake, CA 93555 USA. EM peter.zarras@navy.mil; christopher.e.miller44.civ@mail.mil; cynthia.webber@navy.mil; nicole.anderson@navy.mil; john.stenger-smith@navy.mil FU Department of Defense (DOD) Environmental Security Technology and Certification Program (ESTCP) FX The financial support of the Department of Defense (DOD) Environmental Security Technology and Certification Program (ESTCP), under the direction of Jeffrey Marqusee and Bruce D. Sartwell, Weapons Systems and Platforms Program Manager, is gratefully acknowledged. NR 37 TC 0 Z9 0 U1 4 U2 4 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2079-6412 J9 COATINGS JI Coatings PD SEP PY 2014 VL 4 IS 3 BP 687 EP 700 DI 10.3390/coatings4030687 PG 14 WC Materials Science, Coatings & Films SC Materials Science GA V44FA UT WOS:000209733700017 ER PT J AU Lloyd, JT Clayton, JD Becker, R McDowell, DL AF Lloyd, J. T. Clayton, J. D. Becker, R. McDowell, D. L. TI Simulation of shock wave propagation in single crystal and polycrystalline aluminum SO INTERNATIONAL JOURNAL OF PLASTICITY LA English DT Article DE Shock waves; Dislocations; Elastic-viscoplastic material; Crystal plasticity; Impact testing ID NONLINEAR ANISOTROPIC DESCRIPTION; LITHIUM FLUORIDE CRYSTALS; STRAIN-RATE; FCC METALS; PRECURSOR DECAY; DISLOCATION GENERATION; DYNAMIC DEFORMATION; TEXTURE DEVELOPMENT; CONSTITUTIVE MODEL; GRAIN-ORIENTATION AB A thermoelastic-viscoplastic constitutive model has been developed to model high strain rate deformation in single crystal metals. The thermoelastic formulation employs a material Eulerian strain measure, which has recently been shown to converge more rapidly than traditional Lagrangian strain measures for material undergoing large compression. The viscoplastic formulation is based on the physics of dislocation glide and generation as well as their interaction. This model has been implemented into a one-dimensional, extended finite-difference formulation for anisotropic materials and is used to model shock wave propagation in aluminum single crystals, polycrystals, and pre-textured polycrystals for peak shock pressures ranging from 2 to 110 GPa. The model was able to reproduce experimentally measured particle velocity profiles from both plate impact and laser shock experiments performed on single crystals and polycrystals. Simulations showed that the orientation distribution in vapor-deposited polycrystalline samples can affect the observed elastic precursor decay by a factor of two, as well as change the observed response in laser shock experiments from a dual to single-wave shock structure. Simulations performed on cold rolled aluminum samples showed that an increase in the cold rolling reduction caused a decrease in the number of active slip systems, as well as a decrease in the heterogeneity of total accumulated slip. Finally, a coarse-grained analytical model was developed from results of plane wave simulations and was shown to effectively reproduce plastic heterogeneity induced by single crystal orientations. Simulations in this work showed that single crystal effects play a key role in dictating the macroscopically observed response, which suggests high strain rate experiments that omit detailed initial microstructural characterization do not provide sufficient information for complete mechanistic understanding or model validation. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Lloyd, J. T.; McDowell, D. L.] Georgia Inst Technol, George W Woodruff Sch Mech Engn, Atlanta, GA 30332 USA. [Lloyd, J. T.; Clayton, J. D.; Becker, R.] US Army Res Lab, RDRL WMP C, Impact Phys Branch, Aberdeen Proving Ground, MD 21005 USA. [McDowell, D. L.] Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA. RP Lloyd, JT (reprint author), Georgia Inst Technol, George W Woodruff Sch Mech Engn, Atlanta, GA 30332 USA. EM jeff.lloyd@gatech.edu; john.d.clayton1.civ@mail.mil; richard.c.becker.civ@mail.mil; david.mcdowell@me.gatech.edu RI Clayton, John/C-7760-2009 FU Carter N. Paden, Jr. Distinguished Chair in Metals Processing FX The authors would like to thank Drs. J.C. Crowhurst and C.L. Williams for providing their original data as well as discussing details of sample preparation in references Crowhurst et al. (2011) and Williams et al. (2013), respectively. The authors would like to thank Dr. R.A. Austin for his valuable discussions concerning development of the high strain rate viscoplastic model. D.L. McDowell is grateful for the support of the Carter N. Paden, Jr. Distinguished Chair in Metals Processing. NR 100 TC 9 Z9 9 U1 5 U2 56 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0749-6419 EI 1879-2154 J9 INT J PLASTICITY JI Int. J. Plast. PD SEP PY 2014 VL 60 BP 118 EP 144 DI 10.1016/j.ijplas.2014.04.012 PG 27 WC Engineering, Mechanical; Materials Science, Multidisciplinary; Mechanics SC Engineering; Materials Science; Mechanics GA AM2RI UT WOS:000339698100008 ER PT J AU Lloyd, JT Clayton, JD Austin, RA McDowell, DL AF Lloyd, J. T. Clayton, J. D. Austin, R. A. McDowell, D. L. TI Plane wave simulation of elastic-viscoplastic single crystals SO JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS LA English DT Article DE Single crystal; Micromechanics; High rate deformation; Viscoplasticity; Dislocations ID LITHIUM FLUORIDE CRYSTALS; HIGH-STRAIN RATES; CONSTITUTIVE MODEL; SHOCK-WAVE; DISLOCATION DENSITIES; ALUMINUM; PLASTICITY; DYNAMICS; METALS; COPPER AB Despite the large amount of research that has been performed to quantify the high strain rate response of Aluminum, few studies have addressed effects of crystal orientation and subsequent crystal-level microstructure evolution on its high strain rate response. To study orientation effects in single crystal Al, both a constitutive model and novel numerical method have been developed. A plane wave formulation is developed so that materials undergoing anisotropic viscoplastic deformation can be modeled in a thermodynamically consistent framework. Then, a recently developed high strain rate viscoplastic model is extended to include single crystal effects by incorporating higher order crystal-based thermoelasticity, anisotropic plasticity kinetics, and distinguishing influences of forest and parallel dislocation densities. Steady propagating shock waves are simulated for [100], [110], and [111] oriented single crystals and compared to existing experimental wave profile and strength measurements. Finally, influences of initial orientation and peak pressure ranging from 0 to 30 GPa are quantified. Results indicate that orientation plays a significant role in dictating the high rate response of both the wave profile and the resultant microstructure evolution of Al. The plane wave formulation can be used to evaluate microstructure-sensitive constitutive relations in a computationally efficient framework. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Lloyd, J. T.; McDowell, D. L.] Georgia Inst Technol, George W Woodruff Sch Mech Engn, Atlanta, GA 30332 USA. [Lloyd, J. T.; Clayton, J. D.] US Army, Res Lab, Impact Phys Branch, RDRL WMP C, Aberdeen Proving Ground, MD 21005 USA. [Austin, R. A.] Lawrence Livermore Natl Lab, Mat Modeling & Simulat Grp, Livermore, CA 94550 USA. [McDowell, D. L.] Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA. RP Lloyd, JT (reprint author), US Army, Res Lab, Impact Phys Branch, RDRL WMP C, Aberdeen Proving Ground, MD 21005 USA. EM jeff.lloyd@gatech.edu; john.d.clayton1.civ@mail.mil; austin28@llnl.gov; david.mcdowell@me.gatech.edu RI Austin, Ryan/J-9003-2014; Clayton, John/C-7760-2009 FU U.S. Department of Energy by Lawrence Livermore National Laboratory [DE-AC52-07NA27344]; Carter N. Paden, Jr. Distinguished Chair in Metals Processing FX This work performed, in part, under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344. DLM gratefully acknowledges support of the Carter N. Paden, Jr. Distinguished Chair in Metals Processing. NR 70 TC 10 Z9 10 U1 0 U2 19 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-5096 EI 1873-4782 J9 J MECH PHYS SOLIDS JI J. Mech. Phys. Solids PD SEP PY 2014 VL 69 BP 14 EP 32 DI 10.1016/j.jmps.2014.04.009 PG 19 WC Materials Science, Multidisciplinary; Mechanics; Physics, Condensed Matter SC Materials Science; Mechanics; Physics GA AM2RU UT WOS:000339699300004 ER PT J AU Sanborn, B Weerasooriya, T AF Sanborn, B. Weerasooriya, T. TI Quantifying damage at multiple loading rates to Kevlar KM2 fibers due to weaving, finishing, and pre-twist SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE SHTB; Kevlar KM2; Single fiber; Stress-strain ID MECHANICAL-PROPERTIES AB Understanding Kevlar's mechanical response at strain rates relevant to impact events is essential for the development of numerical simulations of impact events. The strength and orientation of the individual filaments may become compromised as a result of crimping, weaving, or finishing processes required to weave the Kevlar yarn into the fabric used for protective equipment. To elucidate and quantify any damage to the fibers as a result of the weaving or post treatment finishing process, single fibers were extracted from the warp and weft directions of plain woven, hydrophobically treated Kevlar cloth. The strength of these fibers was measured over a wide range of strain rates and compared with fibers extracted from an unwoven yarn. The tensile response was also measured from single fibers subjected to varying levels of shear strain. The tensile strength of the fibers was evaluated at 0.001 s(-1), 1 s(-1), and approximately 1000 s(-1) using a Bose Electroforce test setup and a Hopkinson tension bar modified for fiber experiments. A wide range of gage lengths was investigated to find the effect of defect distribution on the tensile strength of the woven fibers. The results show that fibers taken from the weft direction of the woven fabric decreased in strength 3%-8% compared with the unwoven fiber. The warp fibers were a minimum of 20% weaker than unwoven and weft fibers at all loading rates. Twisted fibers retained 93% of untwisted tensile strength up to a shear strain of about 0.10-0.15. Measured Young's modulus as a function of strain rate and tensile strength as a function of gage length in relation to defect distribution are also presented in this paper. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Sanborn, B.; Weerasooriya, T.] US Army, Res Lab, RDRL, WMP B, Aberdeen Proving Ground, MD 21005 USA. RP Sanborn, B (reprint author), US Army, Res Lab, RDRL, WMP B, Bldg 4600 Aberdeen Proving Ground, Aberdeen Proving Ground, MD 21005 USA. EM brett.sanborn2.ctr@mail.mil NR 14 TC 4 Z9 4 U1 0 U2 19 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X EI 1879-3509 J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD SEP PY 2014 VL 71 BP 50 EP 59 DI 10.1016/j.ijimpeng.2014.04.005 PG 10 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA AL6DA UT WOS:000339221300004 ER PT J AU Kijak, GH Sanders-Buell, E Harbolick, EA Pham, P Chenine, AL Eller, LA Rono, K Robb, ML Michael, NL Kim, JH Tovanabutra, S AF Kijak, Gustavo H. Sanders-Buell, Eric Harbolick, Elizabeth A. Phuc Pham Chenine, Agnes L. Eller, Leigh Anne Rono, Kathleen Robb, Merlin L. Michael, Nelson L. Kim, Jerome H. Tovanabutra, Sodsai TI Targeted deep sequencing of HIV-1 using the IonTorrentPGM platform SO JOURNAL OF VIROLOGICAL METHODS LA English DT Article DE Targeted deep sequencing; Next-generation sequencing; HIV-1; Molecular evolution; IonTorrent ID HUMAN-IMMUNODEFICIENCY-VIRUS; DRUG-RESISTANCE MUTATIONS; TREATMENT-EXPERIENCED PATIENTS; TREATMENT-NAIVE PATIENTS; REVERSE-TRANSCRIPTASE; INFECTION; ESCAPE; SUBPOPULATIONS; IDENTIFICATION; SUPERINFECTION AB The characterization of mixed HIV-1 populations is a key question in clinical and basic research settings. This can be achieved through targeted deep sequencing (TDS), where next-generation sequencing is used to examine in depth a sub-genomic region of interest. This study explores the suitability of IonTorrent PGM(LifeTechnologies) for the TDS-based analysis of HIV-1 evolution. Using laboratory reagents and primary specimens sampled at pre-peak viremia the error rates from misincorporation and in vitro recombination were <0.5%. The sequencing error rate was 2- to 3-fold higher in/around homopolymeric tracts, and could be discerned from true polymorphism using bidirectional sequencing. The limit of detection of complex variants was further lowered by using haplotyping. The application of this system was illustrated on primary samples from an individual infected with HIV-1 followed from pre-peak viremia through six months post-acquisition. TDS provided an augmented view of the extent of genetic diversity, the covariation among polymorphisms, the evolutionary pathways, and the boundaries of the mutational space explored by the viral swarm. Based on its performance, the system can be applied for the characterization of minor viral variants in support of studies of viral evolution, which can inform the rational design of the next generation of vaccines and therapeutics. (C) 2014 Elsevier B.V. All rights reserved. C1 [Kijak, Gustavo H.; Sanders-Buell, Eric; Harbolick, Elizabeth A.; Phuc Pham; Chenine, Agnes L.; Eller, Leigh Anne; Robb, Merlin L.; Tovanabutra, Sodsai] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Bethesda, MD 20817 USA. [Rono, Kathleen] Kenya Govt Med Res Ctr, Walter Reed Project, Kericho, Kenya. [Michael, Nelson L.; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. RP Kijak, GH (reprint author), Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Bethesda, MD 20817 USA. EM gkijak@hivresearch.org FU U.S. Army Medical Research and Materiel Command [Y1-AI-2642-12]; National Institute of Allergy and Infectious Diseases; Henry M. Jackson Foundation for the Advancement of Military Medicine [W81XWH-07-2-0067]; U.S. Department of Defense FX The authors are thankful to the subjects participating in the RV217/ECHO study and to the personnel at the Kenya Medical Research Institute/Walter Reed Project, Kericho, Kenya for their help collecting specimens, epidemiological data, and laboratory technical assistance. The authors would also like to thank Mr. Adam Bates for technical assistance, and Dr. Morgane Rolland for critical reading of the manuscript. This work was supported in part by an Interagency Agreement (Y1-AI-2642-12) between the U.S. Army Medical Research and Materiel Command and the National Institute of Allergy and Infectious Diseases. This work was also supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the U.S. Department of Defense. The opinions expressed in this article are those of the authors and do not represent the official views of the U.S. Department of Health and Human Services, the National Institute of Allergy and Infectious Diseases, the U.S. Department of Defense, or the Department of the Army. NR 50 TC 1 Z9 1 U1 0 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-0934 EI 1879-0984 J9 J VIROL METHODS JI J. Virol. Methods PD SEP 1 PY 2014 VL 205 BP 7 EP 16 DI 10.1016/j.jviromet.2014.04.017 PG 10 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Virology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Virology GA AL5AF UT WOS:000339145200003 PM 24797459 ER PT J AU Carney, N Ghajar, J Jagoda, A Bedrick, S Davis-O'Reilly, C du Coudray, H Hack, D Helfand, N Huddleston, A Nettleton, T Riggio, S AF Carney, Nancy Ghajar, Jamshid Jagoda, Andy Bedrick, Steven Davis-O'Reilly, Cynthia du Coudray, Hugo Hack, Dallas Helfand, Nora Huddleston, Amy Nettleton, Tracie Riggio, Silvana TI Executive Summary of Concussion Guidelines Step 1: Systematic Review of Prevalent Indicators SO NEUROSURGERY LA English DT Editorial Material C1 [Carney, Nancy; Davis-O'Reilly, Cynthia; du Coudray, Hugo; Helfand, Nora; Huddleston, Amy; Nettleton, Tracie] Oregon Hlth & Sci Univ, Dept Med Informat & Clin Epidemiol, Portland, OR 97201 USA. [Bedrick, Steven] Oregon Hlth & Sci Univ, Ctr Spoken Language Understanding, Portland, OR 97201 USA. [Ghajar, Jamshid] Brain Trauma Fdn, New York, NY 10007 USA. [Ghajar, Jamshid] Stanford Univ, Sch Med, Dept Neurosurg, Stanford, CA 94305 USA. [Jagoda, Andy] Icahn Sch Med Mt Sinai, Dept Emergency Med, New York, NY 10029 USA. [Riggio, Silvana] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA. [Riggio, Silvana] Icahn Sch Med Mt Sinai, Dept Neurol, New York, NY 10029 USA. [du Coudray, Hugo] Portland State Univ, Dept Psychol, Portland, OR 97207 USA. [Hack, Dallas] US Army Med Res & Materiel Command, US Army Combat Casualty Care Res Program, Ft Detrick, MD USA. RP Ghajar, J (reprint author), Brain Trauma Fdn, 7 World Trade Ctr,34th Floor,250 Greenwich St, New York, NY 10007 USA. EM ghajar@braintrauma.org NR 0 TC 1 Z9 1 U1 1 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-396X EI 1524-4040 J9 NEUROSURGERY JI Neurosurgery PD SEP PY 2014 VL 75 SU 1 BP S1 EP S2 PG 2 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA AL3XC UT WOS:000339063600001 PM 24867198 ER PT J AU Carney, N Ghajar, J Jagoda, A Bedrick, S Davis-O'Reilly, C du Coudray, H Hack, D Helfand, N Huddleston, A Nettleton, T Riggio, S AF Carney, Nancy Ghajar, Jamshid Jagoda, Andy Bedrick, Steven Davis-O'Reilly, Cynthia du Coudray, Hugo Hack, Dallas Helfand, Nora Huddleston, Amy Nettleton, Tracie Riggio, Silvana TI Concussion Guidelines Step 1: Systematic Review of Prevalent Indicators SO NEUROSURGERY LA English DT Article DE Concussion; Indicators of concussion; Systematic review ID TRAUMATIC BRAIN-INJURY; SPORTS-RELATED CONCUSSION; FOOTBALL PLAYERS; HIGH-SCHOOL; NEUROSURGICAL INTERVENTION; INTRACRANIAL LESIONS; COMPUTED-TOMOGRAPHY; POSTURAL CONTROL; HEAD-INJURY; MILD AB BACKGROUND: Currently, there is no evidence-based definition for concussion that is being uniformly applied in clinical and research settings. OBJECTIVE: To conduct a systematic review of the highest-quality literature about concussion and to assemble evidence about the prevalence and associations of key indicators of concussion. The goal was to establish an evidence-based foundation from which to derive, in future work, a definition, diagnostic criteria, and prognostic indicators for concussion. METHODS: Key questions were developed, and an electronic literature search from 1980 to 2012 was conducted to acquire evidence about the prevalence of and associations among signs, symptoms, and neurologic and cognitive deficits in samples of individuals exposed to potential concussive events. Included studies were assessed for potential for bias and confound and rated as high, medium, or low potential for bias and confound. Those rated as high were excluded from the analysis. Studies were further triaged on the basis of whether the definition of a case of concussion was exclusive or inclusive; only those with wide, inclusive case definitions were used in the analysis. Finally, only studies reporting data collected at fixed time points were used. For a study to be included in the conclusions, it was required that the presence of any particular sign, symptom, or deficit be reported in at least 2 independent samples. RESULTS: From 5437 abstracts, 1362 full-text publications were reviewed, of which 231 studies were included in the final library. Twenty-six met all criteria required to be used in the analysis, and of those, 11 independent samples from 8 publications directly contributed data to conclusions. Prevalent and consistent indicators of concussion are (1) observed and documented disorientation or confusion immediately after the event, (2) impaired balance within 1 day after injury, (3) slower reaction time within 2 days after injury, and/or (4) impaired verbal learning and memory within 2 days after injury. CONCLUSION: The results of this systematic review identify the consistent and prevalent indicators of concussion and their associations, derived from the strongest evidence in the published literature. The product is an evidence-based foundation from which to develop diagnostic criteria and prognostic indicators. C1 [Carney, Nancy; Davis-O'Reilly, Cynthia; du Coudray, Hugo; Helfand, Nora; Huddleston, Amy; Nettleton, Tracie] Oregon Hlth & Sci Univ, Dept Med Informat & Clin Epidemiol, Portland, OR 97201 USA. [Bedrick, Steven] Oregon Hlth & Sci Univ, Ctr Spoken Language Understanding, Portland, OR 97201 USA. [Ghajar, Jamshid] Brain Trauma Fdn, New York, NY 10007 USA. [Ghajar, Jamshid] Stanford Univ, Sch Med, Dept Neurosurg, Stanford, CA 94305 USA. [Jagoda, Andy] Icahn Sch Med Mt Sinai, Dept Emergency Med, New York, NY 10029 USA. [Riggio, Silvana] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA. [Riggio, Silvana] Icahn Sch Med Mt Sinai, Dept Neurol, New York, NY 10029 USA. [du Coudray, Hugo] Portland State Univ, Dept Psychol, Portland, OR 97207 USA. [Hack, Dallas] US Army Med Res & Materiel Command, US Army Combat Casualty Care Res Program, Ft Detrick, MD USA. RP Ghajar, J (reprint author), Brain Trauma Fdn, 7 World Trade Ctr,34th Floor,250 Greenwich St, New York, NY 10007 USA. EM ghajar@braintrauma.org FU US Army Contracting Command, Aberdeen Proving Ground, Natick Contracting Division [W911QY-11-C-0074]; Brain Trauma Foundation FX There are no conflicts of interest. The Brain Trauma Foundation Concussion Guidelines project is supported by the US Army Contracting Command, Aberdeen Proving Ground, Natick Contracting Division, under contract No. W911QY-11-C-0074. The Brain Trauma Foundation provided funding for 2 meetings of the Panel of Technical Experts. Dr Jagoda is a consultant for Banyan Biomarkers. The authors have no personal, financial, or institutional interest in any of the drugs, materials, or devices described in this article. NR 36 TC 11 Z9 11 U1 0 U2 31 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-396X EI 1524-4040 J9 NEUROSURGERY JI Neurosurgery PD SEP PY 2014 VL 75 SU 1 BP S3 EP S15 DI 10.1227/NEU.0000000000000433 PG 13 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA AL3XC UT WOS:000339063600002 PM 25006974 ER PT J AU Zheng, BL Zhou, YZ Mathaudhu, SN Valiev, RZ Tsao, CYA Schoenung, JM Lavernia, EJ AF Zheng, Baolong Zhou, Yizhang Mathaudhu, Suveen N. Valiev, Ruslan Z. Tsao, Chi Y. A. Schoenung, Julie M. Lavernia, Enrique J. TI Multiple and extended shear band formation in MgCuGd metallic glass during high-pressure torsion SO SCRIPTA MATERIALIA LA English DT Article DE Metallic glass; High-pressure torsion; Shear bands; Powder ID ROOM-TEMPERATURE; DEFORMATION AB Mg65Cu25Gd10 bulk metallic glass (BMG), containing a high density of intersecting extended shear bands (SBs), was fabricated from densification of amorphous powder via high-pressure torsion (HPT). The extended SBs, up to 400 nm in width and containing nanocrystalline structures, were studied by electron microscopy. The mechanisms responsible for the formation of the high density of extended SBs are discussed and related to the high hydrostatic pressure and shear strains imposed during HPT of BMGs. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Zheng, Baolong; Zhou, Yizhang; Schoenung, Julie M.; Lavernia, Enrique J.] Univ Calif Davis, Davis, CA 95616 USA. [Mathaudhu, Suveen N.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Valiev, Ruslan Z.] Ufa State Aviat Tech Univ, Ufa 450000, Russia. [Tsao, Chi Y. A.] Natl Cheng Kung Univ, Tainan 701, Taiwan. RP Lavernia, EJ (reprint author), Univ Calif Davis, Davis, CA 95616 USA. EM bzheng@ucdavis.edu RI Mathaudhu, Suveen/B-4192-2009 FU US Army Research Office [W911NF-10-1-0512, W911NF-13-1-0405] FX The authors acknowledge the financial support provided by the US Army Research Office (W911NF-10-1-0512 and W911NF-13-1-0405). NR 22 TC 3 Z9 3 U1 6 U2 43 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6462 J9 SCRIPTA MATER JI Scr. Mater. PD SEP 1 PY 2014 VL 86 BP 24 EP 27 DI 10.1016/j.scriptamat.2014.04.023 PG 4 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA AL3OP UT WOS:000339038400007 ER PT J AU Roege, PE Collier, ZA Mancillas, J McDonagh, JA Linkov, I AF Roege, Paul E. Collier, Zachary A. Mancillas, James McDonagh, John A. Linkov, Igor TI Metrics for energy resilience SO ENERGY POLICY LA English DT Article DE Resilience; Energy security; Energy-informed; Risk ID SYSTEMS AB Energy lies at the backbone of any advanced society and constitutes an essential prerequisite for economic growth, social order and national defense. However there is an Achilles heel to today's energy and technology relationship; namely a precarious intimacy between energy and the fiscal, social, and technical systems it supports. Recently, widespread and persistent disruptions in energy systems have highlighted the extent of this dependence and the vulnerability of increasingly optimized systems to changing conditions. Resilience is an emerging concept that offers to reconcile considerations of performance under dynamic environments and across multiple time frames by supplementing traditionally static system performance measures to consider behaviors under changing conditions and complex interactions among physical, information and human domains. This paper identifies metrics useful to implement guidance for energy-related planning, design, investment, and operation. Recommendations are presented using a matrix format to provide a structured and comprehensive framework of metrics relevant to a system's energy resilience. The study synthesizes previously proposed metrics and emergent resilience literature to provide a multidimensional model intended for use by leaders and practitioners as they transform our energy posture from one of stasis and reaction to one that is proactive and which fosters sustainable growth. Published by Elsevier Ltd. C1 [Roege, Paul E.] Idaho Natl Lab, Idaho Falls, ID 83402 USA. [Collier, Zachary A.; Linkov, Igor] US Army Engineer Res & Dev Ctr, Concord, MA 01742 USA. [Mancillas, James; McDonagh, John A.] US Army Environm Command, Ft Sam Houston, TX 78234 USA. RP Linkov, I (reprint author), US Army Engineer Res & Dev Ctr, 696 Virginia Rd, Concord, MA 01742 USA. EM paul.roege@alum.mit.edu; Zachary.A.Collier@usace.army.mil; james.w.mancillas.civ@mail.mil; john.a.mcdonagh2.civ@mail.mil; Igor.Linkov@usace.army.mil NR 30 TC 13 Z9 17 U1 1 U2 16 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0301-4215 EI 1873-6777 J9 ENERG POLICY JI Energy Policy PD SEP PY 2014 VL 72 BP 249 EP 256 DI 10.1016/j.enpol.2014.04.012 PG 8 WC Energy & Fuels; Environmental Sciences; Environmental Studies SC Energy & Fuels; Environmental Sciences & Ecology GA AL0LA UT WOS:000338817200025 ER PT J AU Williams, EH Davydoy, AV Oleshko, VP Steffens, KL Levin, I Lin, NJ Bertness, KA Manocchi, AK Schreifels, JA Rao, MV AF Williams, Elissa H. Davydoy, Albert V. Oleshko, Vladimir P. Steffens, Kristen L. Levin, Igor Lin, Nancy J. Bertness, Kris A. Manocchi, Amy K. Schreifels, John A. Rao, Mulpuri V. TI Solution-based functionalization of gallium nitride nanowires for protein sensor development SO SURFACE SCIENCE LA English DT Article DE Gallium nitride; Nanowire; Functionalization; Protein; Biosensor ID CHEMICAL FUNCTIONALIZATION; LABEL-FREE; GAN; SPECTROSCOPY; SURFACES; DEVICES AB A solution-based functionalization method for the specific and selective attachment of the streptavidin (SA) protein to gallium nitride (GaN) nanowires (NWs) is presented. By exploiting streptavidin's strong affinity for its ligand biotin, SA immobilization on GaN NWs was achieved by exposing the GaN NW surface to a 3-aminopropyltriethoxysilane (APTES) solution followed by reaction with biotin. Functionalization of the NWs with AFTES was facilitated by the presence of an approximate to 1 nm thick surface oxide layer, which formed on the NWs after exposure to air and oxygen plasma. Biotinylation was accomplished by reacting the APTES-functionalized NI/Vs with sulfo-N-hydroxysuccinimide-biotin at slightly alkaline pH. It was determined that the biotinylated GaN NW surface was specific towards the binding of SA and demonstrated no affinity towards a control protein, bovine serum albumin (BSA). There was however, evidence of non-specific, electrostatic binding of both the SA protein and the BSA protein to the NWs, revealing the importance of the biotinylation step. Successful SA immobilization on the biotinylated GaN NW surface was verified using fluorescence microscopy, field-emission scanning electron microscopy, high-resolution transmission electron microscopy, atomic force microscopy, and X-ray photoelectron spectroscopy. The functionalized GaN NWs demonstrate potential as biosensing platforms for the selective detection of proteins. C1 [Williams, Elissa H.; Davydoy, Albert V.; Oleshko, Vladimir P.; Steffens, Kristen L.; Levin, Igor; Lin, Nancy J.] NIST, Mat Measurement Lab, Gaithersburg, MD 20899 USA. [Williams, Elissa H.; Schreifels, John A.] George Mason Univ, Dept Chem & Biochem, Fairfax, VA 22030 USA. [Williams, Elissa H.; Rao, Mulpuri V.] George Mason Univ, Dept Elect & Comp Engn, Fairfax, VA 22030 USA. [Bertness, Kris A.] NIST, Phys Measurement Lab, Boulder, CO 80305 USA. [Manocchi, Amy K.] Army Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. RP Davydoy, AV (reprint author), NIST, Mat Measurement Lab, 100 Bur Dr, Gaithersburg, MD 20899 USA. EM ehwill@nist.gov; albert.davydov@nist.gov; vladimir.oleshko@nist.gov; kristen.steffens@nist.gov; igor.levin@nist.gov; nancy.lin@nist.gov; bertness@boulder.nist.gov; amy.manocchi.ctr@mail.mil; jschreif@gmu.edu; rmulpuri@gmu.edu FU National Science Foundation [ECCS-0901712]; NIST [SB134110SE0579, SB134111SE0814]; U.S. Army Research Laboratory Postdoctoral Fellowship Program; [MML12-1053-N00]; [0633478] FX The authors are appreciative of the helpful discussions with Dr. Rebecca A. Zangmeister (Material Measurement Laboratory, NIST). EHW, MVR, and JAS gratefully acknowledge the financial support of the National Science Foundation (Grant # ECCS-0901712). VPO gratefully acknowledges the financial support from NIST under contracts SB134110SE0579 and SB134111SE0814 and the MML12-1053-N00 Grant, award #0633478. AKM was supported by a contractual appointment to the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by Oak Ridge Associated Universities. NR 24 TC 5 Z9 5 U1 3 U2 66 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0039-6028 EI 1879-2758 J9 SURF SCI JI Surf. Sci. PD SEP PY 2014 VL 627 BP 23 EP 28 DI 10.1016/j.susc.2014.04.010 PG 6 WC Chemistry, Physical; Physics, Condensed Matter SC Chemistry; Physics GA AK7PZ UT WOS:000338621500004 ER PT J AU Tolmachoff, ED Allmon, W Waits, CM AF Tolmachoff, Erik D. Allmon, William Waits, C. Mike TI Analysis of a high throughput n-dodecane fueled heterogeneous/homogeneous parallel plate microreactor for portable power conversion SO APPLIED ENERGY LA English DT Article DE Microcombustion; Homogeneous-heterogeneous combustion; Portable power conversion ID PREMIXED HYDROGEN/AIR FLAMES; HETERO-/HOMOGENEOUS COMBUSTION; CHANNEL FLOW COMBUSTION; CATALYTIC MICROREACTORS; MICROSCALE COMBUSTION; HOMOGENEOUS IGNITION; DYNAMICS; OXIDATION; MIXTURES; MICROCHANNELS AB To date, conversion of chemical energy to electrical energy for portable power sources has primarily focused on available thermoelectric elements limited to low temperatures and, therefore, low Carnot efficiencies. With advances in thermoelectric (TE) and thermophotovoltaic (TPV) devices allowing higher hot side temperatures, there is an increasing need for small (cm(3) scale, O(10-100) W-chemical), Stable platforms to fully oxidize practical liquid fuels with little pressure drop at high (similar to 800-1000 degrees C), uniform temperatures. Hybrid heterogeneous/homogeneous (HH) reactors provide a means to achieve this. The heterogeneous nature of HH reactors offers inherent stability against reaction extinction while homogeneous reactions are capable of fully converting the fuel; combined, the net effect of HH operation shows promise to both intensify and stabilize a reactor subject to high throughput and heat losses. In this work, we examine the operation of a dodecane fueled parallel plate microreactor with platinum-coated walls targeted for TPV applications. Increasing the confinement of the reactor increases the rate of heat and mass transport to the catalytic walls and, simultaneously the reactor temperature and homogeneous reaction rates. It is shown that, by tuning the reactor confinement, it may be possible to deliver the high, uniform temperatures required for efficient thermal-to-electric power conversion with low diffusivity tactical fuels. Simplified models provide insight into the thermal behavior of the reactor and the role of homogeneous dodecane decomposition on reactor performance. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Tolmachoff, Erik D.; Allmon, William; Waits, C. Mike] US Army Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. RP Tolmachoff, ED (reprint author), US Army Res Lab, Sensors & Elect Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM erik.d.tolmachoff.ctr@mail.mil FU U.S. Army Research Laboratory Postdoctoral Fellowship Program; DoD Supercomputing Resource Center FX This research was supported in part by an appointment to the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through a cooperative agreement with the U.S. Army Research Laboratory. The authors would like to thank M.E. Coltrin for providing helpful insight into the boundary layer modeling and the DoD Supercomputing Resource Center, for providing computer time and support. NR 40 TC 8 Z9 8 U1 2 U2 23 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0306-2619 EI 1872-9118 J9 APPL ENERG JI Appl. Energy PD SEP 1 PY 2014 VL 128 BP 111 EP 118 DI 10.1016/j.apenergy.2014.04.057 PG 8 WC Energy & Fuels; Engineering, Chemical SC Energy & Fuels; Engineering GA AJ6CE UT WOS:000337776500011 ER PT J AU Hong, SK Epureanu, BI Castanier, MP AF Hong, Sung-Kwon Epureanu, Bogdan I. Castanier, Matthew P. TI Parametric reduced-order models of battery pack vibration including structural variation and prestress effects SO JOURNAL OF POWER SOURCES LA English DT Article DE Battery packs; Fatigue life predictions; Prestress; Cell-to-cell parameter variations; High modal density; Parametric reduced-order models ID LITHIUM-ION BATTERY; DYNAMIC ANALYSIS; COMPONENT; REPRESENTATION; SIMULATION AB The goal of this work is to develop a numerical model for the vibration of hybrid electric vehicle (HEV) battery packs to enable probabilistic forced response simulations for the effects of variations. There are two important types of variations that affect their structural response significantly: the prestress that is applied when joining the cells within a pack; and the small, random structural property discrepancies among the cells of a battery pack. The main contributions of this work are summarized as follows. In order to account for these two important variations, a new parametric reduced order model (PROM) formulation is derived by employing three key observations: (1) the stiffness matrix can be parameterized for different levels of prestress, (2) the mode shapes of a battery pack with cell-to-cell variation can be represented as a linear combination of the mode shapes of the nominal system, and (3) the frame holding each cell has vibratory motion. A numerical example of an academic battery pack with pouch cells is presented to demonstrate that the PROM captures the effects of both prestress and structural variation on battery packs. The PROM is validated numerically by comparing full-order finite element models (FEMs) of the same systems. (C) 2014 Elsevier B.V. All rights reserved. C1 [Hong, Sung-Kwon; Epureanu, Bogdan I.] Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA. [Castanier, Matthew P.] US Army Tank Automot Res Dev & Engn Ctr, Warren, MI 48397 USA. RP Hong, SK (reprint author), Univ Michigan, Dept Mech Engn, 2350 Hayward St, Ann Arbor, MI 48109 USA. EM sungkwon@umich.edu; epureanu@umich.edu; matt.castanier@us.army.mil OI Castanier, Matthew/0000-0002-3646-382X; Hong, Sung Kwon/0000-0002-8800-414X FU Automotive Research Center, U.S. Army Center of Excellence for Modeling and Simulation of Ground Vehicles led by the University of Michigan FX The authors gratefully acknowledge the financial support of the Automotive Research Center, a U.S. Army Center of Excellence for Modeling and Simulation of Ground Vehicles led by the University of Michigan. NR 24 TC 2 Z9 2 U1 3 U2 15 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 EI 1873-2755 J9 J POWER SOURCES JI J. Power Sources PD SEP 1 PY 2014 VL 261 BP 101 EP 111 DI 10.1016/j.jpowsour.2014.03.008 PG 11 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA AI6BF UT WOS:000336954100013 ER PT J AU Klapotke, TM Krumm, B Rusan, M Sabatini, JJ AF Klapoetke, Thomas M. Krumm, Burkhard Rusan, Magdalena Sabatini, Jesse J. TI Improved green-light-emitting pyrotechnic formulations based on tris(2,2,2-trinitroethyl)-borate and boron carbide SO CHEMICAL COMMUNICATIONS LA English DT Article AB Green-light-emitting pyrotechnic compositions based on tris(2,2,2-trinitroethyl)borate (TNEB) and boron carbide have been investigated. The best performing formulations were found to be insensitive to various ignition stimuli, and exhibited very high spectral purities and luminosities compared to previously reported green-light-emitting formulations. C1 [Klapoetke, Thomas M.; Krumm, Burkhard; Rusan, Magdalena] Univ Munich, Dept Chem, D-81377 Munich, Germany. [Sabatini, Jesse J.] US Army RDECOM ARDEC, Pyrotech Technol & Prototyping Div, Picatinny Arsenal, NJ 08706 USA. RP Klapotke, TM (reprint author), Univ Munich, Dept Chem, Butenandtstr 5-13, D-81377 Munich, Germany. EM tmk@cup.uni-muenchen.de; jesse.j.sabatini.civ@mail.mil RI Klapoetke, Thomas/B-6055-2014; Krumm, Burkhard/B-7905-2015 OI Klapoetke, Thomas/0000-0003-3276-1157; Krumm, Burkhard/0000-0002-2100-4540 FU Ludwig-Maximilian University of Munich (LMU); U.S. Army Research Laboratory (ARL) [W911NF-09-2-0018]; Armament Research, Development and Engineering Center (ARDEC) [W911NF-12-1-0467]; Office of Naval Research (ONR) [ONR.N00014-10-1-0535, ONR.N00014-12-1-0538]; Cusanuswerk FX Financial support of this work by the Ludwig-Maximilian University of Munich (LMU), the U.S. Army Research Laboratory (ARL) under grant no. W911NF-09-2-0018, the Armament Research, Development and Engineering Center (ARDEC) under grant no. W911NF-12-1-0467, and the Office of Naval Research (ONR) under grant no. ONR.N00014-10-1-0535 and ONR.N00014-12-1-0538 is gratefully acknowledged. The authors acknowledge collaborations with Dr Mila Krupka (OZM Research, Czech Republic) in the development of new testing and evaluation methods for energetic materials and with Dr Muhamed Suceska (Brodarski Institute, Croatia) in the development of new computational codes to predict the detonation and propulsion parameters of novel explosives. We are indebted to and thank Drs Betsy M. Rice and Brad Forch (ARL, Aberdeen, Proving Ground, MD) for many inspired discussions. The Cusanuswerk is gratefully acknowledged for the award of a PhD scholarship (M. Rusan). NR 14 TC 7 Z9 7 U1 1 U2 19 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1359-7345 EI 1364-548X J9 CHEM COMMUN JI Chem. Commun. PD AUG 28 PY 2014 VL 50 IS 67 BP 9581 EP 9583 DI 10.1039/c4cc04616a PG 3 WC Chemistry, Multidisciplinary SC Chemistry GA AM9QT UT WOS:000340216800038 PM 25012058 ER PT J AU Ren, XM Price, SC Jackson, AC Pomerantz, N Beyer, FL AF Ren, Xiaoming Price, Samuel C. Jackson, Aaron C. Pomerantz, Natalie Beyer, Frederick L. TI Highly Conductive Anion Exchange Membrane for High Power Density Fuel-Cell Performance SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE anion exchange membrane; conductivity; water transport; mechanic properties; fuel cell ID REACTIVE BLOCK POLYMERS; ELECTROLYTE MEMBRANES; COPOLYMERS; CO2 AB Anion exchange membrane fuel cells (AEMFCs) are regarded as a new generation of fuel cell technology that has the potential to overcome many obstacles of the mainstream proton exchange membrane fuel cells (PEMFCs) in cost, catalyst stability, efficiency, and system size. However, the low ionic conductivity and poor thermal stability of current anion exchange membranes (AEMs) have been the key factors limiting the performance of AEMFCs. In this study, an AEM made of styrenic diblock copolymer with a quaternary ammonium-functionalized hydrophilic block and a cross-linkable hydrophobic block and possessing bicontinuous phases of a hydrophobic network and hydrophilic conduction paths was found to have high ionic conductivity at 98 mS cm(-1) and controlled membrane swelling with water uptake at 117 wt % at 22 degrees C. Membrane characterizations and fuel cell tests of the new AEM were carried out together with a commercial AEM, Tokuyama A201, for comparison. The high ionic conductivity and water permeability of the new membrane reported in this study is attributed to the reduced torturosity of the ionic conduction paths, while the hydrophobic network maintains the membrane mechanical integrity, preventing excessive water uptake. C1 [Ren, Xiaoming] US Army Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. [Price, Samuel C.; Jackson, Aaron C.; Beyer, Frederick L.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen, MD 21005 USA. [Pomerantz, Natalie] US Army NSRDEC, Natick Soldier Ctr, Natick, MA 01760 USA. RP Ren, XM (reprint author), US Army Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. EM xiaoming.ren.civ@mail.mil FU U.S. Army Research Laboratory; Army Research Laboratory [ORISE 1120-1120-99] FX S.C.P. and A.C.J. were supported by the Postgraduate Research Participation Program at the U.S. Army Research Laboratory, administered by the Oak Ridge Institute of Science and Education through an interagency agreement between the U.S. Department of Energy and Army Research Laboratory (Contract ORISE 1120-1120-99). NR 21 TC 16 Z9 16 U1 12 U2 95 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD AUG 27 PY 2014 VL 6 IS 16 BP 13330 EP 13333 DI 10.1021/am503870g PG 4 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA AO2CB UT WOS:000341122000004 PM 25101785 ER PT J AU Das, S Dubey, M Roelofs, A AF Das, Saptarshi Dubey, Madan Roelofs, Andreas TI High gain, low noise, fully complementary logic inverter based on bi-layer WSe2 field effect transistors SO APPLIED PHYSICS LETTERS LA English DT Article ID THIN-FILM-TRANSISTOR; MOS2 TRANSISTORS; MULTILAYER MOS2; TRANSPARENT; CONTACTS AB In this article, first, we show that by contact work function engineering, electrostatic doping and proper scaling of both the oxide thickness and the flake thickness, high performance p- and n-type WSe2 field effect transistors (FETs) can be realized. We report record high drive current of 98 mu A/mu m for the electron conduction and 110 mu A/mu m for the hole conduction in Schottky barrier WSe2 FETs. Then, we combine high performance WSe2 PFET with WSe2 NFET in double gated transistor geometry to demonstrate a fully complementary logic inverter. We also show that by adjusting the threshold voltages for the NFET and the PFET, the gain and the noise margin of the inverter can be significantly enhanced. The maximum gain of our chemical doping free WSe2 inverter was found to be similar to 25 and the noise margin was close to its ideal value of similar to 2.5V for a supply voltage of V-DD = 5.0 V. (C) 2014 AIP Publishing LLC. C1 [Das, Saptarshi; Roelofs, Andreas] Argonne Natl Lab, Ctr Nanoscale Mat, Argonne, IL 60439 USA. [Dubey, Madan] US Army, Res Lab, Adelphi, MD 20783 USA. RP Das, S (reprint author), Argonne Natl Lab, Ctr Nanoscale Mat, 9700 S Cass Ave, Argonne, IL 60439 USA. RI Roelofs, Andreas/H-1742-2011 OI Roelofs, Andreas/0000-0003-4141-3082 FU DOE Office of High Energy Physics under DoE Contract [DE-AC02-06CH11357]; U. S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-06CH11357] FX The authors acknowledge the Army Research laboratory. This work was supported by the DOE Office of High Energy Physics under DoE Contract No. DE-AC02-06CH11357. Use of the Center for Nanoscale Materials was supported by the U. S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No. DE-AC02-06CH11357. NR 19 TC 23 Z9 23 U1 3 U2 54 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD AUG 25 PY 2014 VL 105 IS 8 AR 083511 DI 10.1063/1.4894426 PG 5 WC Physics, Applied SC Physics GA AQ4HE UT WOS:000342753500099 ER PT J AU Tordesillas, A Pucilowski, S Walker, DM Peters, JF Walizer, LE AF Tordesillas, Antoinette Pucilowski, Sebastian Walker, David M. Peters, John F. Walizer, Laura E. TI Micromechanics of vortices in granular media: connection to shear bands and implications for continuum modelling of failure in geomaterials SO INTERNATIONAL JOURNAL FOR NUMERICAL AND ANALYTICAL METHODS IN GEOMECHANICS LA English DT Article DE granular material; complex networks; contact cycles; localised failure; diffuse failure; shear band; discrete element method ID ASSEMBLIES; ELEMENT; LOCALIZATION; DEFORMATION; EVOLUTION; PARTICLE; CONTACT; NETWORK AB Recent analysis of data from triaxial tests on sand and discrete element simulations indicate the final pattern of failure is encoded in grain motions during the nascent stages of loading. We study vortices that are evident from grain displacements at the start of loading and bear a direct mathematical connection to boundary conditions, uniform continuum strain and shear bands. Motions of three grains in mutual contact, that is, 3-cycles, manifest vortices. In the initial stages of loading, 3-cycles initiate a rotation around a region Omega* where the shear band ultimately develops. This bias sets a course in 3-cycle evolution, determining where they will more likely collapse. A multiscale spatial analysis of 3-cycle temporal evolution provides quantitative evidence that the most stable, persistent 3-cycles degrade preferentially in Omega*, until essentially depleted when the shear band is fully formed. The transition towards a clustered distribution of persistent 3-cycles occurs early in the loading history-and coincides with the persistent localisation of vortices in Omega*. In 3D samples, no evidence of spatial clustering in persistent 3-cycle deaths is found in samples undergoing diffuse failure, while early clustering manifests in a sample that ultimately failed by strain localisation. This study not only delivered insights into the possible structural origins of vortices in dense granular systems but also a tool for the early detection of the mode of failure-localised versus diffuse-a sample will ultimately undergo. Copyright (C) 2014 John Wiley & Sons, Ltd. C1 [Tordesillas, Antoinette; Pucilowski, Sebastian; Walker, David M.] Univ Melbourne, Dept Math & Stat, Parkville, Vic 3010, Australia. [Tordesillas, Antoinette] Univ Melbourne, Sch Earth Sci, Parkville, Vic 3010, Australia. [Tordesillas, Antoinette] Univ Melbourne, Melbourne Energy Inst, Parkville, Vic 3010, Australia. [Peters, John F.; Walizer, Laura E.] US Army Engineer Res & Dev Ctr, Geotech Lab, Vicksburg, MS 39180 USA. RP Tordesillas, A (reprint author), Univ Melbourne, Dept Math & Stat, Parkville, Vic 3010, Australia. EM atordesi@unimelb.edu.au RI Walker, David/Q-1995-2016 OI Walker, David/0000-0001-9322-6743 FU Australian Research Council [DP120104759]; US Army Research Office Single Investigator Award Scheme [W911NF-11-1-0175]; Gilbert Riggs PhD Scholarship; Melbourne Energy Institute FX We thank Dr Qun Lin for useful discussions. We are also grateful to Felix Darve, Luc Sibille, Ali Daouadji and Francois Nicot for kindly permitting use of their diffuse failure data and Mark Hopkins for the triaxial polyellipsoid data. This study was supported by the Australian Research Council (Discovery Projects DP120104759), the Melbourne Energy Institute, US Army Research Office Single Investigator Award Scheme W911NF-11-1-0175 and the Gilbert Riggs PhD Scholarship (SP). NR 53 TC 10 Z9 10 U1 3 U2 18 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0363-9061 EI 1096-9853 J9 INT J NUMER ANAL MET JI Int. J. Numer. Anal. Methods Geomech. PD AUG 25 PY 2014 VL 38 IS 12 BP 1247 EP 1275 DI 10.1002/nag.2258 PG 29 WC Engineering, Geological; Materials Science, Multidisciplinary; Mechanics SC Engineering; Materials Science; Mechanics GA AN5AR UT WOS:000340601900003 ER PT J AU McNeil, MM Cano, M Miller, ER Petersen, BW Engler, RJM Bryant-Genevier, MG AF McNeil, Michael M. Cano, Maria Miller, Elaine R. Petersen, Brett W. Engler, Renata J. M. Bryant-Genevier, Marthe G. TI Ischemic cardiac events and other adverse events following ACAM2000 (R) smallpox vaccine in the Vaccine Adverse Event Reporting System SO VACCINE LA English DT Article DE ACAM2000 (R); Ischemic cardiac events; Myocarditis; Pericarditis; Myo/pericarditis ID ACUTE MYOCARDIAL-INFARCTION; JANUARY-OCTOBER 2003; UNITED-STATES; MILITARY; PROGRAM; SAFETY; EXPERIENCE AB Background: The Vaccine Adverse Event Reporting System (VAERS) is a passive reporting system, used for monitoring the safety of all US licensed vaccines. In March 2008, ACAM2000 (R) replaced Dryvax (R) as the only licensed smallpox vaccine and is administered to all persons entering military service and certain civilian researchers. In 2011, routine data mining of VAERS identified a vaccine safety concern resulting in acute ischemic cardiac events (ICE) following ACAM2000 (R). Methods: During March 1, 2008 through June 30, 2013, we reviewed all serious reports received following ACAM2000 (R) and classified them by diagnostic category. We identified possible ICE cases by searching the Medical Dictionary for Regulatory Affairs (MedDRA (R)) terms for "myocardial ischaemia," "acute myocardial infarction," "myocardial infarction," and "ischaemia," and applied standardized surveillance case definitions. Results: VAERS received 1149 reports following ACAM2000 (R) administration; 169 (14.7%) were serious (resulting in permanent disability, hospitalization or prolongation of hospitalization, life-threatening illness or death), including one death. The two most frequent diagnostic categories for serious reports were cardiovascular and other infectious conditions. The MedDRA (R) search found 31 reports of possible ICE after receipt of ACAM2000 (R) vaccine. Of a total 30 possible ICE cases with demographic information, all but one was male; the age range was 20-45 years (median 32) and median interval to onset of symptoms was 12 days. On clinical review there were 16 cases of myocarditis/pericarditis and 15 ICE cases. Conclusions: Our review of the data mining signal did not substantiate the concerns about ICE after ACAM2000 (R). Our study also suggests that with current pre-vaccination screening, cardiac morbidity in generally healthy vaccinated populations remains uncommon. Published by Elsevier Ltd. C1 [McNeil, Michael M.; Cano, Maria; Miller, Elaine R.] Ctr Dis Control & Prevent, Immunizat Safety Off, Div Healthcare Qual Promot, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Petersen, Brett W.] Ctr Dis Control & Prevent, Poxvirus & Rabies Branch, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Engler, Renata J. M.] Mil Vaccine Agcy, Vaccine Healthcare Ctr Network, US Army Publ Hlth Command, Walter Reed Natl Mil Med Ctr, Bethesda, MD 20889 USA. [Bryant-Genevier, Marthe G.] US FDA, Off Biostat & Epidemiol, Ctr Biol Evaluat & Res, Rockville, MD 20857 USA. RP McNeil, MM (reprint author), Ctr Dis Control & Prevent, MS D-126,1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM mmm2@cdc.gov FU comprehensive VAERS investigations; CDC FX This work was supported by the comprehensive VAERS investigations submitted by the clinical staff of the Department of Defense Vaccine Healthcare Centers Network (Division of the Military Vaccine Agency, U.S. Army Public Health Command) Myocarditis/Pericarditis Clinical Case Management Consortium (including the DoD allergists-immunologists/cardiologists leaders - Dr. Limone C. Collins, Dr. Jay Montgomery, COL John E. Atwood, LTC Brian Hemann and LTC Barnett Gibbs). The authors thank Frank DeStefano, MD MPH, for his critical review of the manuscript. The funding for this study was provided solely by the CDC. NR 35 TC 1 Z9 1 U1 0 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD AUG 20 PY 2014 VL 32 IS 37 BP 4758 EP 4765 DI 10.1016/j.vaccine.2014.06.034 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA AO0DR UT WOS:000340979800010 PM 24951868 ER PT J AU Bates, ME Sparrevik, M de Lichy, N Linkov, I AF Bates, Matthew E. Sparrevik, Magnus de Lichy, Nicolas Linkov, Igor TI The Value of Information for Managing Contaminated Sediments SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID MULTICRITERIA DECISION-ANALYSIS; RISK-ASSESSMENT; GRENLAND FJORDS; MANAGEMENT; CHALLENGES; NORWAY; TRENDS AB Effective management of contaminated sediments is important for long-term human and environmental health, but site-management decisions are often made under high uncertainty and without the help of structured decision support tools. Potential trade-offs between remedial costs, environmental effects, human health risks, and societal benefits, as well as fundamental differences in stakeholder priorities, complicate decision making. Formal decision-analytic tools such as multicriteria decision analysis (MCDA) move beyond ad hoc decision support to quantitatively and holistically rank management alternatives and add transparency and replicability to the evaluation process. However, even the best decisions made under uncertainty may be found suboptimal in hindsight, once additional scientific, social, economic, or other details become known. Value of information (VoI) analysis extends MCDA by systematically evaluating the impact of uncertainty on a decision. VoI prioritizes future research in terms of expected decision relevance by helping decision makers estimate the likelihood that additional information will improve decision confidence or change their selection of a management plan. In this study, VoI analysis evaluates uncertainty, estimates decision confidence, and prioritizes research to inform selection of a sediment capping strategy for the dibenzo-p-dioxin and -furan contaminated Grenland fiord system in southern Norway. The VoI model extends stochastic MCDA to model decisions with and without simulated new information and compares decision confidence across scenarios with different degrees of remaining uncertainty. Results highlight opportunities for decision makers to benefit from additional information by anticipating the improved decision confidence (or lack thereof) expected from reducing uncertainties for each criterion or combination of criteria. This case study demonstrates the usefulness of VoI analysis for environmental decisions by predicting when decisions can be made confidently, for prioritizing areas of research to pursue to improve decision confidence, and for differentiating between decision-relevant and decision-irrelevant differences in evaluation perspectives, all of which help guide meaningful deliberation toward effective consensus solutions. C1 [Bates, Matthew E.; Linkov, Igor] US Army Corps Engineers, Environm Lab, Engineer Res & Dev Ctr, Concord, MA 01742 USA. [Sparrevik, Magnus] Norwegian Def Estates Agcy, NO-0103 Oslo, Norway. [Sparrevik, Magnus] Norwegian Geotech Inst, NO-0806 Oslo, Norway. [Sparrevik, Magnus] Norwegian Univ Technol, Dept Ind Econ & Technol Management, N-7491 Trondheim, Norway. [de Lichy, Nicolas] London Sch Econ, London WC2A 2AE, England. RP Bates, ME (reprint author), US Army Corps Engineers, Environm Lab, Engineer Res & Dev Ctr, 696 Virginia Rd, Concord, MA 01742 USA. EM Matthew.E.Bates@usace.army.mil FU Norwegian Research Council FX The authors would like to thank previous studies for the work performed on the Norwegian Grenland fjord system, especially the Opticap project (www.opticap.no), the SEDFLEX project, and the Norwegian Research Council that financed those studies. Thanks are also due to Kelsie Baker and Cate Fox-Lent for help with graphics, editing, and data curation, and to Professor Jeff Keisler who was instrumental in teaching and critiquing the VoI methods. The authors additionally thank Dr. Todd Bridges, Dr. Martin Schultz, and are grateful for financial support from the Dredging Operation Environmental Research (DOER) program of the US Army Corps of Engineers (USAGE). Permission was granted by the USAGE Chief of Engineers to publish this material. NR 36 TC 2 Z9 2 U1 2 U2 22 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD AUG 19 PY 2014 VL 48 IS 16 BP 9478 EP 9485 DI 10.1021/es500717t PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AN6JW UT WOS:000340701800065 PM 24957130 ER PT J AU Kenefick, RW Sollanek, KJ Charkoudian, N Sawka, MN AF Kenefick, Robert W. Sollanek, Kurt J. Charkoudian, Nisha Sawka, Michael N. TI Impact of skin temperature and hydration on plasma volume responses during exercise SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE vasculature fluid shifts; hydration state; plasma volume loss ID HEAT-STRESS; AEROBIC PERFORMANCE; BLOOD-VOLUME; FLUID SHIFTS; BODY; DEHYDRATION; MEN; HYPOHYDRATION; MECHANISMS; ERGOMETRY AB Heat stress and hydration may both alter plasma volume (PV) responses during acute exercise; potential interactions have not been fully studied. The purpose of this study was to determine the effect of graded elevations in skin temperature (T-sk) on PV changes during steady-state exercise under conditions of euhydration (EU) and hypohydration (HYPO, -4% of body mass). Thirty-two men (22 +/- 4 yr) were divided into four cohorts (n = 8 each) and completed EU and HYPO trials in one environment [ambient temperature (T-a) 10, 20, 30, and 40 degrees C]. Thirty minutes of cycle ergometry (50% V-O2peak) was performed. Core (T-re) and mean skin (T-sk) temperatures were measured; changes in PV, total circulating protein (TCP), and mean arterial pressure (MAP) were calculated; and skin blood flow (SkBF) was estimated. Hypohydration decreased (P < 0.05) PV by 200 ml (-5.7%) but did not alter TCP. Plasma loss was not different between EU and HYPO during exercise at any T-a. Plasma losses were greater (P < 0.05) with elevated Ta with an average -130, -174, -294, and -445 ml losses during the 10, 20, 30, and 40 degrees C trials, respectively. Significant (P < 0.05) correlations (r = 0.50 to 0.84) were found between Delta TCP and Delta PV during exercise when Tsk was cool/warm (< 33 degrees C; T-a 10, 20, and 30 degrees C), but not at 40 degrees C (high Tsk). We conclude that 1) graded skin warming proportionally accentuated plasma loss; 2) plasma loss was associated with plasma protein efflux at lower T-sk and SkBF; 3) at high Tsk, additional plasma loss likely results from increased net filtration at the capillaries; and 4) HYPO did not alter vascular fluid loss during exercise in any environment. C1 [Kenefick, Robert W.; Sollanek, Kurt J.; Charkoudian, Nisha] US Army Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA 01760 USA. [Sawka, Michael N.] Georgia Inst Technol, Sch Appl Physiol, Atlanta, GA 30332 USA. RP Kenefick, RW (reprint author), US Army Res Inst Environm Med, Thermal & Mt Med Div, Kansas St, Natick, MA 01760 USA. EM Robert.W.KeneFick.civ@mail.mil NR 39 TC 1 Z9 1 U1 10 U2 29 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 EI 1522-1601 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD AUG 15 PY 2014 VL 117 IS 4 BP 413 EP 420 DI 10.1152/japplphysiol.00415.2014 PG 8 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA AO4LQ UT WOS:000341310200009 PM 24994888 ER PT J AU Cohen, K Zhao, Q Swami, A AF Cohen, Kobi Zhao, Qing Swami, Ananthram TI Optimal Index Policies for Anomaly Localization in Resource-Constrained Cyber Systems SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article DE Anomaly localization; composite hypothesis testing; sequential hypothesis testing; sequential probability ratio test (SPRT) ID COMPOSITE HYPOTHESES; SEQUENTIAL PROCEDURE; WHEREABOUTS SEARCH; TESTS AB The problem of anomaly localization in a resource-constrained cyber system is considered. Each anomalous component of the system incurs a cost per unit time until its anomaly is identified and fixed. Different anomalous components may incur different costs depending on their criticality to the system. Due to resource constraints, only one component can be probed at each given time. The observations from a probed component are realizations drawn from two different distributions depending on whether the component is normal or anomalous. The objective is a probing strategy that minimizes the total expected cost, incurred by all the components during the detection process, under reliability constraints. We consider both independent and exclusive models. In the former, each component can be abnormal with a certain probability independent of other components. In the latter, one and only one component is abnormal. We develop optimal index policies under both models. The proposed index policies apply to a more general case where a subset (more than one) of the components can be probed simultaneously. The problem under study also finds applications in spectrum scanning in cognitive radio networks and event detection in sensor networks. C1 [Cohen, Kobi; Zhao, Qing] Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 95616 USA. [Swami, Ananthram] Army Res Lab, Adelphi, MD 20783 USA. RP Cohen, K (reprint author), Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 95616 USA. EM yscohen@ucdavis.edu; qzhao@ucdavis.edu; a.swami@ieee.org FU Army Research Labortatory [W911NF1120086]; National Science Foundation [CCF-1320065] FX This work was supported by Army Research Labortatory under Grant W911NF1120086 and by the National Science Foundation under Grant CCF-1320065. This work was presented in part in the Proceedings of the IEEE Global Conference on Signal and Information Processing (GlobalSIP), Austin, Texas, USA, December 2013. NR 32 TC 7 Z9 7 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1053-587X EI 1941-0476 J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD AUG 15 PY 2014 VL 62 IS 16 BP 4224 EP 4236 DI 10.1109/TSP.2014.2332982 PG 13 WC Engineering, Electrical & Electronic SC Engineering GA AN8HO UT WOS:000340845200015 ER PT J AU Gauer, RL Burket, J Horowitz, E AF Gauer, Robert L. Burket, Jeffrey Horowitz, Eric TI Common Questions About Outpatient Care of Premature Infants SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID LOW-BIRTH-WEIGHT; RESPIRATORY SYNCYTIAL VIRUS; FEEDING PRETERM INFANTS; IRON-DEFICIENCY ANEMIA; CATCH-UP GROWTH; GASTROESOPHAGEAL-REFLUX; HOSPITAL DISCHARGE; YOUNG-CHILDREN; DEVELOPMENTAL-DISABILITY; RISK-FACTORS AB Preterm births (deliveries before 37 weeks' gestation) comprise 12% of all U.S. births and are responsible for one-third of all infant deaths. Neonatal medical advances have increased survival, and primary care physicians often care for infants who were in the neonatal intensive care unit after birth. Functions of the primary care physician include coordination of medical and social services, nutritional surveillance, and managing conditions associated with prematurity. Parental guidance and encouragement are often necessary to ensure appropriate feeding and infant weight gain. Enriched formula and nutrient fortifiers are used for infants with extrauterine growth restriction. Iron supplementation is recommended for breastfed infants, and iron-fortified formula for formula-fed infants. Screening for iron deficiency anemia in preterm infants should occur at four months of age and at nine to 12 months of age. Gastroesophageal reflux is best treated with nonpharmacologic options because medications provide no long-term benefits. Neurodevelopmental delay occurs in up to 50% of preterm infants. Developmental screening should be performed at every well-child visit. If developmental delay is suspected, more formalized testing may be required with appropriate referral. To prevent complications from respiratory syncytial virus infection, palivizumab is recommended in the first year of life during the respiratory syncytial virus season for all infants born before 29 weeks' gestation and for infants born between 29 and 32 weeks' gestation who have chronic lung disease. Most preterm infants have minimal long-term sequelae. (C) Copyright 2014 American Academy of Family Physicians.) C1 [Gauer, Robert L.] Womack Army Med Ctr, Ft Bragg, NC 28310 USA. [Burket, Jeffrey] Gen Leonard Wood Army Community Hosp, Ft Leonard Wood, MO USA. [Horowitz, Eric] Duke Univ, Med Ctr, Div Neonatol, Durham, NC USA. RP Gauer, RL (reprint author), Womack Army Med Ctr, Bldg 4,2817 Riley Rd, Ft Bragg, NC 28310 USA. EM robert.l.gauer2.civ@mail.mil NR 57 TC 3 Z9 3 U1 1 U2 9 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X EI 1532-0650 J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD AUG 15 PY 2014 VL 90 IS 4 BP 244 EP 251 PG 8 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA AN3VL UT WOS:000340516700008 PM 25250998 ER PT J AU de Rosset, WS Montgomery, JS AF de Rosset, William S. Montgomery, Jonathan S. TI Cobalt-base alloy gun barrel study SO WEAR LA English DT Article DE Cobalt-base alloy; Muzzle wear; Erosion; Firing tests; Wear pattern; Gun tube liner material ID REFRACTORY-METAL LINERS; WEAR AB Firing tests of a small caliber experimental gun barrel made of a cobalt-base alloy have been conducted with the purpose of determining the degree of wear and erosion due to excessive firing durations. The small amount of barrel material loss makes the cobalt-base alloy an excellent candidate for use as a gun liner. An unusual wear pattern resulting from this loss was observed near the muzzle. Elimination of chemical and thermal effects made a plausible explanation of the wear pattern possible. (C) 2014 Elsevier B.V. All rights reserved. C1 [de Rosset, William S.; Montgomery, Jonathan S.] US Army Res Lab, ATTN RDRL WMM F, Aberdeen Proving Ground, MD 21005 USA. RP de Rosset, WS (reprint author), US Army Res Lab, ATTN RDRL WMM F, Aberdeen Proving Ground, MD 21005 USA. EM william.s.derosset.ctr@mail.mil FU U.S. Army Research Laboratory FX The authors thank the U.S. Army Research Laboratory for sponsoring this work. We are indebted to George Gibbs (USMC) and the Small Business Innovative Research Program for the cobalt-based alloy barrels. We also wish to acknowledge the BEMIS measurements by Robert Keppinger, the microscopy/EDS work by Bradley Klotz, and the sample mounting and polishing by James Catalano. NR 9 TC 5 Z9 5 U1 3 U2 11 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0043-1648 J9 WEAR JI Wear PD AUG 15 PY 2014 VL 316 IS 1-2 BP 119 EP 123 DI 10.1016/j.wear.2014.05.001 PG 5 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA AK7JX UT WOS:000338605700013 ER PT J AU Sambanthamoorthy, K Feng, XR Patel, R Patel, S Paranavitana, C AF Sambanthamoorthy, Karthik Feng, Xiaorong Patel, Ruchi Patel, Sneha Paranavitana, Chrysanthi TI Antimicrobial and antibiofilm potential of biosurfactants isolated from lactobacilli against multi-drug-resistant pathogens SO BMC MICROBIOLOGY LA English DT Article DE Anti-adhesive; Anti-biofilm; Biosurfactant; Antimicrobial; Lactobacillus jensenii; Lactobacillus rhamnosus ID STREPTOCOCCUS-THERMOPHILUS-A; BIOFILM FORMATION; SILICONE-RUBBER; PROBIOTIC BACTERIA; MICROBIAL ADHESION; SURFACTANTS; INHIBITION; LACTOCOCCUS-LACTIS-53; MICROORGANISMS; BIOTECHNOLOGY AB Background: Biosurfactants (BS) are amphiphilic compounds produced by microbes, either on the cell surface or secreted extracellularly. BS exhibit strong antimicrobial and anti-adhesive properties, making them good candidates for applications used to combat infections. In this study, our goal was to assess the in vitro antimicrobial, anti-adhesive and anti-biofilm abilities of BS produced by Lactobacillus jensenii and Lactobacillus rhamnosus against clinical Multidrug Resistant (MDR) strains of Acinetobacter baumannii, Escherichia coli, and Staphylococcus aureus (MRSA). Cell-bound BS from both L. jensenii and L. rhamnosus were extracted and isolated. The surface activities of crude BS samples were evaluated using an oil spreading assay. The antimicrobial, anti-adhesive and anti-biofilm activities of both BS against the above mentioned MDR pathogens were determined. Results: Surface activities for both BS ranged from 6.25 to 25 mg/ml with clear zones observed between 7 and 11 cm. BS of both L. jensenii and L. rhamnosus showed antimicrobial activities against A. baumannii, E. coli and S. aureus at 25-50 mg/ml. Anti-adhesive and anti-biofilm activities were also observed for the aforementioned pathogens between 25 and 50 mg/ml. Finally, analysis by electron microscope indicated that the BS caused membrane damage for A. baumannii and pronounced cell wall damage in S. aureus. Conclusion: Our results indicate that BS isolated from two Lactobacilli strains has antibacterial properties against MDR strains of A. baumannii, E. coli and MRSA. Both BS also displayed anti-adhesive and anti-biofilm abilities against A. baumannii, E. coli and S. aureus. Together, these capabilities may open up possibilities for BS as an alternative therapeutic approach for the prevention and/or treatment of hospital-acquired infections. C1 [Sambanthamoorthy, Karthik; Feng, Xiaorong; Patel, Ruchi; Patel, Sneha; Paranavitana, Chrysanthi] Walter Reed Army Inst Res, Bacterial Dis Branch, Dept Wound Infect, Silver Spring, MD 20910 USA. RP Paranavitana, C (reprint author), Walter Reed Army Inst Res, Bacterial Dis Branch, Dept Wound Infect, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM cparanavit@hotmail.com FU Defense Medical Research and Development Program (DMRDP) FX The findings and opinions expressed herein belong to the authors and do not necessarily reflect the official views of the WRAIR, the U.S. Army, or the Department of Defense. This work was supported by a Defense Medical Research and Development Program (DMRDP) funding awarded to Dr. Chrysanthi Paranavitana. The authors would like to thank Ms. Amy Michels for editing the manuscript and Mr. Edward A. Asafo-Adjei for helping with electron microscopy experiments. NR 40 TC 16 Z9 16 U1 2 U2 31 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2180 J9 BMC MICROBIOL JI BMC Microbiol. PD AUG 14 PY 2014 VL 14 AR 197 DI 10.1186/1471-2180-14-197 PG 9 WC Microbiology SC Microbiology GA AO3DP UT WOS:000341209100001 PM 25124936 ER PT J AU Tieu, HV Suntarattiwong, P Puthanakit, T Chotpitayasunondh, T Chokephaibulkit, K Sirivichayakul, S Buranapraditkun, S Rungrojrat, P Chomchey, N Tsiouris, S Hammer, S Nandi, V Ananworanich, J AF Tieu, Hong-Van Suntarattiwong, Piyarat Puthanakit, Thanyawee Chotpitayasunondh, Tawee Chokephaibulkit, Kulkanya Sirivichayakul, Sunee Buranapraditkun, Supranee Rungrojrat, Patcharawee Chomchey, Nitiya Tsiouris, Simon Hammer, Scott Nandi, Vijay Ananworanich, Jintanat CA Thai TB Px Study Grp TI Comparing Interferon-Gamma Release Assays to Tuberculin Skin Test in Thai Children with Tuberculosis Exposure SO PLOS ONE LA English DT Article ID MYCOBACTERIUM-TUBERCULOSIS; LATENT TUBERCULOSIS; CHILDHOOD TUBERCULOSIS; INFECTION; DIAGNOSIS; PERFORMANCE; METAANALYSIS; CHALLENGES; DISEASE; UTILITY AB Background: Data on the performance of interferon-gamma release assays (IGRAs), QuantiFERON TB Gold In-tube (QFNGIT) and T-Spot. TB, in diagnosing tuberculosis (TB) are limited in Southeast Asia. This study aims to compare the performances of the two IGRAs and TST in Thai children with recent TB exposure. Methods: This multicenter, prospective study enrolled children with recent exposure to active TB adults. Children were investigated for active TB. TST was performed and blood collected for T-Spot. TB and QFNGIT. Results: 158 children were enrolled (87% TB-exposed and 13% active TB, mean age 7.2 years). Only 3 children had HIV infection. 66.7% had TST >= 10 mm, while 38.6% had TST >= 15 mm. 32.5% had positive QFNGIT; 29.9% had positive T-Spot. TB. QFNGIT and T-Spot. TB positivity was higher among children with active TB compared with TB-exposed children. No indeterminate IGRA results were detected. No statistically significant differences between the performances of the IGRAs and TST at the two cut-offs with increasing TB exposure were detected. Concordance for positive IGRAs and TST ranged from 42-46% for TST >= 10 mm and 62-67% for TST >= 15 mm. On multivariable analyses, exposure to household primary/secondary caregiver with TB was associated with positive QFNGIT. Higher TB contact score and active TB were associated with positive T-Spot. TB. Conclusions: Both QFNGIT and T-Spot. TB performed well in our Thai pediatric study population. No differences in the performances between tests with increasing TB exposure were found. Due to accessibility and low cost, using TST may more ideal than IGRAs in diagnosing latent and active TB in healthy children in Thailand and other similar settings. C1 [Tieu, Hong-Van; Nandi, Vijay] New York Blood Ctr, Lindsley F Kimball Res Inst, Lab Infect Dis Prevent, New York, NY 10021 USA. [Tieu, Hong-Van; Tsiouris, Simon; Hammer, Scott] Columbia Univ, Med Ctr, Dept Med, Div Infect Dis, New York, NY USA. [Suntarattiwong, Piyarat; Chotpitayasunondh, Tawee] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. [Puthanakit, Thanyawee] Chulalongkorn Univ, Fac Med, Dept Pediat, Bangkok 10330, Thailand. [Puthanakit, Thanyawee; Ananworanich, Jintanat] Thai Red Cross AIDS Res Ctr, HIV Netherlands Australia Thailand Res Collaborat, Bangkok, Thailand. [Chokephaibulkit, Kulkanya] Mahidol Univ, Siriraj Hosp, Fac Med, Dept Pediat, Bangkok 10700, Thailand. [Sirivichayakul, Sunee; Buranapraditkun, Supranee; Ananworanich, Jintanat] Chulalonglongkorn Univ, Dept Med, Fac Med, Bangkok, Thailand. [Rungrojrat, Patcharawee; Chomchey, Nitiya; Ananworanich, Jintanat] Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, Thailand. [Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. RP Tieu, HV (reprint author), New York Blood Ctr, Lindsley F Kimball Res Inst, Lab Infect Dis Prevent, New York, NY 10021 USA. EM htieu@nybloodcenter.org FU Tibotec REACH Initiative FX This study was funded by a competitive, investigator-initiated research grant from Tibotec REACH Initiative. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 33 TC 5 Z9 5 U1 0 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD AUG 14 PY 2014 VL 9 IS 8 AR e105003 DI 10.1371/journal.pone.0105003 PG 13 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AO0QT UT WOS:000341017000085 PM 25121513 ER PT J AU Borodin, O Bedrov, D AF Borodin, Oleg Bedrov, Dmitry TI Interfacial Structure and Dynamics of the Lithium Alkyl Dicarbonate SEI Components in Contact with the Lithium Battery Electrolyte SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID LI-ION BATTERIES; SOLVATION SHEATH STRUCTURE; LIQUID ETHYLENE CARBONATE; AB-INITIO CALCULATIONS; MOLECULAR-DYNAMICS; PROPYLENE CARBONATE; GRAPHITE/ELECTROLYTE INTERFACE; NONAQUEOUS ELECTROLYTES; INTERPHASIAL CHEMISTRY; SURFACE-CHEMISTRY AB Molecular dynamics simulations were performed on the dilithium ethylene dicarbonate (Li2EDC) and dilithium butylene dicarbonate (Li2BDC) components of the lithium battery solid electrolyte interphase (SEI) in contact with mixed solvent electrolyte: ethylene carbonate (EC):dimethyl carbonate (DMC) (EC:DMC = 3:7) doped with LiPF6. The many-body polarizable APPLE&P force field was used in the simulations. Examination of the SEI-electrolyte interface revealed an enrichment of EC and PF6- molecules and a depletion of DMC at the interfacial layer next to the SEI surface compared to bulk electrolyte concentrations. The EC and DMC molecules at the interfacial layer next to the SEI demonstrated a preferential orientation of carbonyl oxygens directed toward the SEI surface. The process of the Li+ ion desolvation from electrolyte and intercalation into the SEI was examined. During the initial desolvation step, the Li+ cation showed a preference to shed DMC molecules compared to losing the EC or PF6- moieties. The PF6- anion was involved in the Li+ cation desolvation process at high temperatures. The activation energies for the Li+ solvation-desolvation reaction were estimated to be 0.42-0.46 eV for the Li2EDC-electrolyte and Li2BDC-electrolyte interfaces. C1 [Borodin, Oleg] US Army Res Lab, Electrochem Branch, Sensor & Electron Devices Directorate, Adelphi, MD 20783 USA. [Bedrov, Dmitry] Univ Utah, Dept Mat Sci & Engn, Salt Lake City, UT 84112 USA. RP Borodin, O (reprint author), US Army Res Lab, Electrochem Branch, Sensor & Electron Devices Directorate, Adelphi, MD 20783 USA. EM oleg.a.borodin.civ@mail.mil RI Borodin, Oleg/B-6855-2012 OI Borodin, Oleg/0000-0002-9428-5291 FU Army Research Laboratory [W911NF-12-2-0023] FX This research at University of Utah was sponsored by the Army Research Laboratory under Cooperative Agreement Number W911NF-12-2-0023. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. O.B. acknowledges helpful discussions with Arthur von Cresce, T. Richard Jow, Marco Olguin, and Kang Xu (ARL). D.B. acknowledges the Center of High Performance Computing at the University of Utah for technical support and allocation of computing time. NR 74 TC 13 Z9 13 U1 7 U2 91 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD AUG 14 PY 2014 VL 118 IS 32 BP 18362 EP 18371 DI 10.1021/jp504598n PG 10 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA AN2VQ UT WOS:000340444500010 ER PT J AU Barker, AJ Douglas, TA Jacobson, AD McClelland, JW Ilgen, AG Khosh, MS Lehn, GO Trainor, TP AF Barker, Amanda J. Douglas, T. A. Jacobson, A. D. McClelland, J. W. Ilgen, A. G. Khosh, M. S. Lehn, G. O. Trainor, T. P. TI Late season mobilization of trace metals in two small Alaskan arctic watersheds as a proxy for landscape scale permafrost active layer dynamics SO CHEMICAL GEOLOGY LA English DT Article DE Trace metals; Arctic; Surface waters; Permafrost; Active layer; Geochemistry ID NORTHERN ALASKA; ORGANIC-CARBON; THERMAL STATE; LENA RIVER; RUSSIA; GEOCHEMISTRY; ENVIRONMENT; SPECIATION; HYDROLOGY; DISCHARGE AB Increasing air temperatures in the Arctic have the potential to degrade permafrost and promote the downward migration of the seasonally thawed active layer into previously frozen material. This may expose frozen soils to mineral weathering that could affect the geochemical composition of surface waters. Determining watershed system responses to drivers such as a changing climate relies heavily on understanding seasonal controls on freshwater processes. The majority of studies on elemental concentrations in Arctic river systems have focused on sampling only from spring snowmelt to the summer season. Consequently, there remains a limited understanding of surface water geochemistry, particularly with respect to trace metals, during late fall and early winter. To examine the variability of metal concentrations as a function of seasonality, we measured trace metal concentrations from spring melt to fall freeze-up in 2010 in two high Arctic watersheds: Imnavait Creek, North Slope, Alaska and Roche Mountanee Creek, Brooks Range, Alaska. We focused on aluminum (Al), barium (Ba), iron (Fe), manganese (Mn), nickel (Ni) and zinc (Zn). Concentrations of 'dissolved' (<0.45 mu m) Al, Ba, Fe, and Mn in Imnavait Creek waters and Ba in Roche Mountanee waters were highest in late fall/early winter. To link observed surface water concentrations at Imnavait Creek to parent soil material we analyzed the elemental composition of a soil core from the watershed and tracked the soil temperatures as a function of time and depth. The results from this study show a distinct seasonal signature of trace metal concentrations in late fall that correlates with the depth of the thawed active layer. Published by Elsevier B. V. C1 [Barker, Amanda J.; Douglas, T. A.] US Army Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. [Barker, Amanda J.; Trainor, T. P.] Univ Alaska Fairbanks, Dept Chem & Biochem, Fairbanks, AK 99775 USA. [Jacobson, A. D.; Lehn, G. O.] Northwestern Univ, Dept Earth & Planetary Sci, Evanston, IL 60208 USA. [McClelland, J. W.; Khosh, M. S.] Univ Texas Austin, Inst Marine Sci, Port Aransas, TX 78373 USA. [Ilgen, A. G.] Sandia Natl Labs, Dept Geochem, Albuquerque, NM 87185 USA. RP Barker, AJ (reprint author), Dept Chem & Biochem, 900 Yukon Dr Rm 194, Fairbanks, AK 99775 USA. EM ajbarker@alaska.edu RI Jacobson, Andrew/I-6102-2015; McClelland, James/C-5396-2008; OI McClelland, James/0000-0001-9619-8194; Khosh, Matthew/0000-0002-5457-7724; Barker, Amanda/0000-0003-0703-2702 FU U.S. National Science Foundation, Office of Polar Programs to [0806714, 0806643, 0806827]; National Science Foundation [1023052]; SnowNET Project through a collaboration; Matthew Sturm (CRREL-Alaska, now at the University of Alaska Fairbanks) FX Funding for this project was from the U.S. National Science Foundation, Office of Polar Programs to Douglas (# 0806714), Jacobson (# 0806643) and McClelland (# 0806827). Toolik Field Station of the University of Alaska Fairbanks-Institute of Arctic Biology and CH2MHill Polar Field Services provided logistical support. Numerous students and collaborators are acknowledged on this project for field and laboratory assistance. Soil horizon profiles were provided as part of a field workshop on Arctic Soils offered by the University of Alaska Fairbanks taught by Dr. Chien-Lu Ping and Dr. Gary Michaelson of the Palmer Research Center, School of Natural Resources and Agriculture Sciences, University of Alaska Fairbanks. Air temperature data are courtesy of the National Science Foundation funded (award # 1023052) SnowNET Project through a collaboration with Matthew Sturm (CRREL-Alaska, now at the University of Alaska Fairbanks). Toolik area precipitation data were provided by Jessie Cherry of the University of Alaska Fairbanks. Soil characterization and metal analysis (XRD, XRF and ICP-MS instrumentation) were accomplished at the University of Alaska FairbanksAdvanced Instrumentation Laboratory with the assistance of Karen Spaleta, Maciej Sliwinski and Ken Severin. We alsowish to acknowledge the editor and anonymous reviewers for their feedback, which greatly strengthened the article. NR 52 TC 3 Z9 4 U1 2 U2 34 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2541 EI 1878-5999 J9 CHEM GEOL JI Chem. Geol. PD AUG 14 PY 2014 VL 381 BP 180 EP 193 DI 10.1016/j.chemgeo.2014.05.012 PG 14 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA AM9NO UT WOS:000340208500016 ER PT J AU Honnold, SP Bakken, RR Fisher, D Lind, CM Cohen, JW Eccleston, LT Spurgers, KB Maheshwari, RK Glass, PJ AF Honnold, Shelley P. Bakken, Russell R. Fisher, Diana Lind, Cathleen M. Cohen, Jeffrey W. Eccleston, Lori T. Spurgers, Kevin B. Maheshwari, Radha K. Glass, Pamela J. TI Second Generation Inactivated Eastern Equine Encephalitis Virus Vaccine Candidates Protect Mice against a Lethal Aerosol Challenge SO PLOS ONE LA English DT Article ID ALPHAVIRUS ENCEPHALITIS; STRUCTURAL INTEGRITY; IMMUNE INTERFERENCE; VENEZUELAN; GLYCOPROTEIN; PRESERVATION; INFECTION; IMMUNOGENICITY; RESPONSES; MEMBRANE AB Currently, there are no FDA-licensed vaccines or therapeutics for eastern equine encephalitis virus (EEEV) for human use. We recently developed several methods to inactivate CVEV1219, a chimeric live-attenuated eastern equine encephalitis virus (EEEV). Dosage and schedule studies were conducted to evaluate the immunogenicity and protective efficacy of three potential second-generation inactivated EEEV (iEEEV) vaccine candidates in mice: formalin-inactivated CVEV1219 (fCVEV1219), INA-inactivated CVEV1219 (iCVEV1219) and gamma-irradiated CVEV1219 (gCVEV1219). Both fCVEV1219 and gCVEV1219 provided partial to complete protection against an aerosol challenge when administered by different routes and schedules at various doses, while iCVEV1219 was unable to provide substantial protection against an aerosol challenge by any route, dose, or schedule tested. When evaluating antibody responses, neutralizing antibody, not virus specific IgG or IgA, was the best correlate of protection. The results of these studies suggest that both fCVEV1219 and gCVEV1219 should be evaluated further and considered for advancement as potential second-generation inactivated vaccine candidates for EEEV. C1 [Honnold, Shelley P.; Bakken, Russell R.; Fisher, Diana; Lind, Cathleen M.; Cohen, Jeffrey W.; Eccleston, Lori T.; Spurgers, Kevin B.; Glass, Pamela J.] US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Honnold, Shelley P.; Maheshwari, Radha K.] Uniformed Serv Univ Hlth Sci, Dept Pathol, Bethesda, MD 20814 USA. RP Honnold, SP (reprint author), US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. EM shelley.p.honnold.mil@mail.mil FU Defense Threat Reduction Agency (DTRA) [H.H.0003_07_RD_B] FX This work was funded by the Defense Threat Reduction Agency (DTRA) Project Number H.H.0003_07_RD_B. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 33 TC 2 Z9 2 U1 2 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD AUG 12 PY 2014 VL 9 IS 8 AR e104708 DI 10.1371/journal.pone.0104708 PG 18 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AO3LJ UT WOS:000341230400072 PM 25116127 ER PT J AU Ferguson, JB Aguirre, I Lopez, H Schultz, BF Cho, K Rohatgi, PK AF Ferguson, J. B. Aguirre, Ismael Lopez, Hugo Schultz, Benjamin F. Cho, Kyu Rohatgi, Pradeep K. TI Tensile properties of reactive stir-mixed and squeeze cast Al/CuOnp-based metal matrix nanocomposites SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Metal matrix composites; Casting; Grain boundaries; Mechanical properties; Aluminum alloys ID AZ31 MAGNESIUM ALLOY; CARBON NANOTUBES; ALUMINUM-ALLOY; FAILURE STRAIN; REINFORCED AL; COMPOSITES; STRENGTH; MG; MICROSTRUCTURE; SUPERPOSITION AB Metal matrix nanocomposites (MMNCs) are expected to possess superior mechanical properties that would make them ideal candidates to increase energy and fuel efficiency in the transportation sector. However, economical methods to disperse nanoparticles in metals must be developed to reach this goal. In this work, MMNCs were synthesized from Al and CuOnp, by reactive stir mixing followed by squeeze casting. Subsequently, the tensile properties of these materials were measured to determine the effect of the initial nanoparticle (NP) concentration of CuOnp on the exhibited tensile properties. Comparison of the MMNCs processed under the same conditions and tested in the as-cast condition shows an apparent increase in ultimate tensile strength (UTS), but little change in yield strength and ductility. Grain size was found to decrease with increasing CuOnp concentration. The MMNC behavior is compared to Al-Cu alloys in an attempt to shed light on the mechanisms responsible for the change in properties. (C) 2014 Elsevier B.V. All rights reserved. C1 [Ferguson, J. B.; Lopez, Hugo; Schultz, Benjamin F.; Rohatgi, Pradeep K.] Univ Wisconsin, Dept Mat Sci & Engn, Milwaukee, WI 53211 USA. [Aguirre, Ismael] Univ Autonoma Nuevo Leon, Fac Ingn Mecan & Elect, San Nicolas De Los Garza 66451, NL, Mexico. [Cho, Kyu] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Schultz, BF (reprint author), Univ Wisconsin, Dept Mat Sci & Engn, 3200 North Cramer St, Milwaukee, WI 53211 USA. EM jbf2@uwm.edu; aguirre.rojo@gmail.com; hlopez@uwm.edu; bfs2@uwm.edu; kyu.c.cho2.civ@mail.mil; prohatgi@uwm.edu FU U.S. Army Research Laboratory [W911NF-08-2-0014] FX This material is based upon work supported by the U.S. Army Research Laboratory under Cooperative Agreement no. W911NF-08-2-0014. The views, opinions, and conclusions made in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 38 TC 3 Z9 3 U1 2 U2 21 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 EI 1873-4936 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD AUG 12 PY 2014 VL 611 BP 326 EP 332 DI 10.1016/j.msea.2014.06.008 PG 7 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA AM7AY UT WOS:000340018300038 ER PT J AU Banks, HD AF Banks, Harold D. TI Profound effect of fluorine substitution on the rate of nucleophilic substitution of aziridine in solution SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Banks, Harold D.] US Army, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM harold.d.banks4.civ@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 560-ORGN PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8KC UT WOS:000349167403147 ER PT J AU Bedrov, D Vatamanu, J Vatamanu, M Borodin, O AF Bedrov, Dmitry Vatamanu, Jenel Vatamanu, Mihaela Borodin, Oleg TI Molecular dynamics simulations of carbonates based electrolytes at charged surfaces SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Bedrov, Dmitry; Vatamanu, Jenel; Vatamanu, Mihaela] Univ Utah, Salt Lake City, UT 84112 USA. [Borodin, Oleg] US Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA. EM d.bedrov@utah.edu RI Borodin, Oleg/B-6855-2012 OI Borodin, Oleg/0000-0002-9428-5291 NR 0 TC 0 Z9 0 U1 0 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 209-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165104445 ER PT J AU Borodin, O Olguin, M Allen, J Henderson, W AF Borodin, Oleg Olguin, Marco Allen, Joshua Henderson, Wesley TI Insight into structure and transport of carbonate, nitrile electrolytes, and SEI components SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 248th National Meeting of the American-Chemical-Society (ACS) CY AUG 10-14, 2014 CL San Francisco, CA SP Amer Chem Soc C1 [Borodin, Oleg; Olguin, Marco; Allen, Joshua] Army Res Lab, Adelphi, MD 20789 USA. [Henderson, Wesley] Pacific NW Natl Lab, Richland, WA 99352 USA. EM olegutah@gmail.com RI Borodin, Oleg/B-6855-2012 OI Borodin, Oleg/0000-0002-9428-5291 NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 10 PY 2014 VL 248 MA 206-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA CA8JN UT WOS:000349165104442 ER EF