FN Thomson Reuters Web of Science™ VR 1.0 PT S AU Gupta, N AF Gupta, Neelam BE Druy, MA Crocombe, RA Bannon, DP TI Performance Characterization of VNIR & SWIR Spectropolarimetric Imagers SO NEXT-GENERATION SPECTROSCOPIC TECHNOLOGIES VIII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Next-Generation Spectroscopic Technologies VIII CY APR 20-22, 2015 CL Baltimore, MD SP SPIE DE Hyperspectral; polarization; spectropolarimetric; imager; VNIR; SWIR; acousto-optic tunable filter; AOTF; TeO2; Stokes polarization ID ACOUSTOOPTIC TUNABLE FILTER; CRYSTALS; SYSTEM AB Two compact prototype spectropolarimetric imagers operating in the visible-near-infrared (VNIR) and shortwave-infrared (SWIR) regions were developed. Each of these imagers uses a noncollinear acousto-optic tunable filter (AOTF) and collects data with four linear incident polarizations-vertical, horizontal and +/- 45 degrees. The spectral region of operation for the first imager is from 450 to 800 nm and the second one from 1000 to 1600 nm. These imagers are field-portable and before field test were characterized for their performance in collecting hyperspectral and full linear polarization signatures. Image cubes of scenes with natural objects were collected and analyzed. Here, we present imaging and spectral analysis results for these imagers. C1 US Army, Res Lab, Adelphi, MD 20817 USA. RP Gupta, N (reprint author), US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20817 USA. NR 27 TC 2 Z9 2 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-598-8 J9 PROC SPIE PY 2015 VL 9482 AR 948216 DI 10.1117/12.2177099 PG 11 WC Optics; Spectroscopy SC Optics; Spectroscopy GA BD0AF UT WOS:000357016100033 ER PT S AU Martin, MZ Fox, RV Miziolek, AW DeLucia, FC Andre, N AF Martin, Madhavi Z. Fox, Robert V. Miziolek, Andrzej W. DeLucia, Frank C., Jr. Andre, Nicolas BE Druy, MA Crocombe, RA Bannon, DP TI Spectral Analysis of Rare Earth Elements using Laser-Induced Breakdown Spectroscopy SO NEXT-GENERATION SPECTROSCOPIC TECHNOLOGIES VIII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Next-Generation Spectroscopic Technologies VIII CY APR 20-22, 2015 CL Baltimore, MD SP SPIE DE Laser-induced breakdown spectroscopy; LIBS of rare earth magnets; LIBS for detection rare earth elements ID SPECTROMETRY AB There is growing interest in rapid analysis of rare earth elements (REEs) both due to the need to find new natural sources to satisfy increased demand in their use in various electronic devices, as well as the fact that they are used to estimate actinide masses for nuclear safeguards and nonproliferation. Laser-Induced Breakdown Spectroscopy (LIBS) appears to be a particularly well-suited spectroscopy-based technology to rapidly and accurately analyze the REEs in various matrices at low concentration levels (parts-per-million). Although LIBS spectra of REEs have been reported for a number of years, further work is still necessary in order to be able to quantify the concentrations of various REEs in real-world complex samples. LIBS offers advantages over conventional solution-based radiochemistry in terms of cost, analytical turnaround, waste generation, personnel dose, and contamination risk. Rare earth elements of commercial interest are found in the following three matrix groups: 1) raw ores and unrefined materials, 2) as components in refined products such as magnets, lighting phosphors, consumer electronics (which are mostly magnets and phosphors), catalysts, batteries, etc., and 3) waste/recyclable materials (aka e-waste). LIBS spectra for REEs such as Gd, Nd, and Sm found in rare earth magnets are presented. C1 [Martin, Madhavi Z.] Oak Ridge Natl Lab, Oak Ridge, TN 37831 USA. [Fox, Robert V.] Idaho Natl Lab, Idaho Falls, ID 83415 USA. [Miziolek, Andrzej W.; DeLucia, Frank C., Jr.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Andre, Nicolas] Univ Tennessee, Ctr Renewable Carbon, Knoxville, TN 37831 USA. RP Martin, MZ (reprint author), Oak Ridge Natl Lab, Oak Ridge, TN 37831 USA. EM Martinm1@ornl.gov OI Martin, Madhavi/0000-0002-6677-2180 NR 22 TC 0 Z9 0 U1 3 U2 8 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-598-8 J9 PROC SPIE PY 2015 VL 9482 AR 94820G DI 10.1117/12.2178192 PG 8 WC Optics; Spectroscopy SC Optics; Spectroscopy GA BD0AF UT WOS:000357016100011 ER PT S AU Sorauf, KJ Bauer, AJR Miziolek, AW De Lucia, FC AF Sorauf, Kellen J. Bauer, Amy J. R. Miziolek, Andrzej W. De Lucia, Frank C., Jr. BE Druy, MA Crocombe, RA Bannon, DP TI Spectral Data Analysis Approaches for Improved Provenance Classification SO NEXT-GENERATION SPECTROSCOPIC TECHNOLOGIES VIII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Next-Generation Spectroscopic Technologies VIII CY APR 20-22, 2015 CL Baltimore, MD SP SPIE DE laser-induced breakdown spectroscopy (LIBS); provenance analysis; forensics; discriminant analysis; elemental fingerprinting ID INDUCED BREAKDOWN SPECTROSCOPY; PLASMA-MASS SPECTROMETRY; DISCRIMINATION; MINERALS; RESIDUES; EXAMPLE; SENSOR; FIELD AB In the last 10 years various chemometric methods have been developed and used for the analysis of spectra generated by Laser Induced Breakdown Spectroscopy (LIBS). One of the more successful and proven methods is Partial Least Squares Discriminant Analysis (PLS-DA). Recently PLS-DA was utilized for purposes of provenance of spent brass cartridges and achieved correct classification at around 93% with a false alarm rate of around 5%. The LIBS spectra from the cartridge samples are rich in emission lines from numerous mostly metallic elements comprising the brass and the cited results were based on the analysis of the full broadband high resolution spectra. It was observed that some of the lines were clearly saturated in all spectra, while others were sometimes saturated due to pulse-to-pulse variation. The pulse-to-pulse variation was also evident in the intensity variations of the spectra within cartridges and between cartridges. In order to improve on the accuracy of the classification we have developed some preprocessing strategies including the removal of spectral wavelength ranges susceptible to saturation and normalization techniques to diminish the effects of intensity variations in the spectra. The results indicate incremental improvements when applying additional preprocessing steps to the limit of 100% True Positives and 0% False Positives when utilizing selected wavelengths that are normalized and averaged. C1 [Sorauf, Kellen J.] Regis Univ, Denver, CO 80221 USA. [Bauer, Amy J. R.] TSI Inc, Minneapolis, MN USA. [Miziolek, Andrzej W.; De Lucia, Frank C., Jr.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Sorauf, KJ (reprint author), Regis Univ, Denver, CO 80221 USA. EM ksorauf@regis.edu NR 27 TC 0 Z9 0 U1 1 U2 6 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-598-8 J9 PROC SPIE PY 2015 VL 9482 AR 948212 DI 10.1117/12.2177913 PG 10 WC Optics; Spectroscopy SC Optics; Spectroscopy GA BD0AF UT WOS:000357016100029 ER PT S AU Cam, H AF Cam, Hasan BE Ternovskiy, IV Chin, P TI Risk Assessment by Dynamic Representation of Vulnerability, Exploitation, and Impact SO CYBER SENSING 2015 SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Cyber Sensing CY APR 21, 2015 CL Baltimore, MD SP SPIE DE Risk assessment; vulnerability; exploitation likelihood and impact; Markov model; attack state AB Assessing and quantifying cyber risk accurately in real-time is essential to providing security and mission assurance in any system and network. This paper presents a modeling and dynamic analysis approach to assessing cyber risk of a network in real-time by representing dynamically its vulnerabilities, exploitations, and impact using integrated Bayesian network and Markov models. Given the set of vulnerabilities detected by a vulnerability scanner in a network, this paper addresses how its risk can be assessed by estimating in real-time the exploit likelihood and impact of vulnerability exploitation on the network, based on real-time observations and measurements over the network. The dynamic representation of the network in terms of its vulnerabilities, sensor measurements, and observations is constructed dynamically using the integrated Bayesian network and Markov models. The transition rates of outgoing and incoming links of states in hidden Markov models are used in determining exploit likelihood and impact of attacks, whereas emission rates help quantify the attack states of vulnerabilities. Simulation results show the quantification and evolving risk scores over time for individual and aggregated vulnerabilities of a network. C1 Army Res Lab, Adelphi, MD 20773 USA. RP Cam, H (reprint author), Army Res Lab, Adelphi, MD 20773 USA. EM hasan.cam.civ@mail.mil NR 12 TC 0 Z9 0 U1 4 U2 7 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-574-2 J9 PROC SPIE PY 2015 VL 9458 AR 945809 DI 10.1117/12.2177405 PG 9 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA BC9NR UT WOS:000356673200007 ER PT S AU Hutchinson, S Erbacher, RF AF Hutchinson, Steve Erbacher, Robert F. BE Ternovskiy, IV Chin, P TI ASN Reputation System Model SO CYBER SENSING 2015 SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Cyber Sensing CY APR 21, 2015 CL Baltimore, MD SP SPIE DE Autonomous System Numbers; Reputation System; Intrusion Detection; Cyber Security AB Network security monitoring is currently challenged by its reliance on human analysts and the inability for tools to generate indications and warnings for previously unknown attacks. We propose a reputation system based on IP address set membership within the Autonomous System Number (ASN) system. Essentially, a metric generated based on the historic behavior, or misbehavior, of nodes within a given ASN can be used to predict future behavior and provide a mechanism to locate network activity requiring inspection. This will provide reinforcement of notifications and warnings and lead to inspection for ASNs known to be problematic even if initial inspection leads to interpretation of the event as innocuous. We developed proof of concept capabilities to generate the IP address to ASN set membership and analyze the impact of the results. These results clearly show that while some ASNs are one-offs with individual or small numbers of misbehaving IP addresses, there are definitive ASNs with a history of long term and wide spread misbehaving IP addresses. These ASNs with long histories are what we are especially interested in and will provide an additional correlation metric for the human analyst and lead to new tools to aid remediation of these IP address blocks. C1 [Hutchinson, Steve] ICF Int Army Res Lab, Adelphi, MD 20783 USA. [Erbacher, Robert F.] Army Res Lab, Adelphi, MD 20783 USA. RP Hutchinson, S (reprint author), ICF Int Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM Steve.Hutchinson@mail.mil; Robert.F.Erbacher.civ@mail.mil NR 17 TC 0 Z9 0 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-574-2 J9 PROC SPIE PY 2015 VL 9458 AR 94580A DI 10.1117/12.2177464 PG 8 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA BC9NR UT WOS:000356673200008 ER PT S AU Burnette, C Schneider, M Agarwal, S Deterline, D Geyer, C Phan, CD Lydic, RM Green, K Swett, B AF Burnette, Chris Schneider, Matt Agarwal, Sanjeev Deterline, Diane Geyer, Chris Phan, Chung D. Lydic, Richard M., Jr. Green, Kevin Swett, Bruce BE Bishop, SS Isaacs, JC TI Near Real-Time, On-the-Move Multi-Sensor Integration and Computing Framework SO DETECTION AND SENSING OF MINES, EXPLOSIVE OBJECTS, AND OBSCURED TARGETS XX SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Detection and Sensing of Mines, Explosive Objects, and Obscured Targets XX CY APR 20-23, 2015 CL Baltimore, MD SP SPIE DE Sensor integration framework; Vehicle computing; service architecture; near real-time; Route Clearance Patrols (RCPs); Mine detection AB Implanted mines and improvised devices are a persistent threat to Warfighters. Current Army countermine missions for route clearance need on-the-move standoff detection to improve the rate of advance. Vehicle-based forward looking sensors such as electro-optical and infrared (EO/IR) devices can be used to identify potential threats in near real-time (NRT) at safe standoff distance to support route clearance missions. The MOVERS (Micro-Cloud for Operational, Vehicle-Based EO-IR Reconnaissance System) is a vehicle-based multi-sensor integration and exploitation system that ingests and processes video and imagery data captured from forward-looking EO/IR and thermal sensors, and also generates target/feature alerts, using the Video Processing and Exploitation Framework (VPEF) "plug and play" video processing toolset. The MOVERS Framework provides an extensible, flexible, and scalable computing and multi-sensor integration GOTS framework that enables the capability to add more vehicles, sensors, processors or displays, and a service architecture that provides low-latency raw video and metadata streams as well as a command and control interface. Functionality in the framework is exposed through the MOVERS SDK which decouples the implementation of the service and client from the specific communication protocols. C1 [Burnette, Chris; Schneider, Matt; Deterline, Diane] EOIR Technol, Fredericksburg, VA 22408 USA. [Agarwal, Sanjeev; Phan, Chung D.; Lydic, Richard M., Jr.] US Army Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA. [Geyer, Chris; Green, Kevin; Swett, Bruce] EOIR Technol, Springfield, VA 22150 USA. RP Burnette, C (reprint author), EOIR Technol, 4729 Carr Dr, Fredericksburg, VA 22408 USA. NR 5 TC 0 Z9 0 U1 1 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-570-4 J9 PROC SPIE PY 2015 VL 9454 AR 94540N DI 10.1117/12.2177760 PG 14 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA BC9OO UT WOS:000356708000020 ER PT S AU Farrell, ME Holthoff, EL Pellegrino, PM AF Farrell, Mikella E. Holthoff, Ellen L. Pellegrino, Paul M. BE Bishop, SS Isaacs, JC TI Raman Detection of improvised explosive device (IED) material fabricated using drop-on-demand Inkjet Technology on several real world surfaces SO DETECTION AND SENSING OF MINES, EXPLOSIVE OBJECTS, AND OBSCURED TARGETS XX SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Detection and Sensing of Mines, Explosive Objects, and Obscured Targets XX CY APR 20-23, 2015 CL Baltimore, MD SP SPIE DE Raman; substrate; Ammonium nitrate; plastic; fabric; human hair; wood; rubber ID ION MOBILITY SPECTROMETRY; INDUCED BREAKDOWN SPECTROSCOPY; POLYMORPHIC PHASE-TRANSITION; AMMONIUM-NITRATE PARTICLES; ENHANCED RAMAN; TRACE EXPLOSIVES; MASS-SPECTROMETRY; COMPOSITION C-4; SOLID-STATE; FINGERPRINTS AB The requirement to detect hazardous materials (i.e., chemical, biological, and explosive) on a host of materials has led to the development of hazard detection systems. These new technologies and their capabilities could have immediate uses for the US military, national security agencies, and environmental response teams in efforts to keep people secure and safe. In particular, due to the increasing use by terrorists, the detection of common explosives and improvised explosive device (IED) materials have motivated research efforts toward detecting trace (i.e., particle level) quantities on multiple commonly encountered surfaces (e.g., textiles, metals, plastics, natural products, and even people). Non-destructive detection techniques can detect trace quantities of explosive materials; however, it can be challenging in the presence of a complex chemical background. One spectroscopic technique gaining increased attention for detection is Raman. One popular explosive precursor material is ammonium nitrate (AN). The material AN has many agricultural applications, however it can also be used in the fabrication of IEDs or homemade explosives (HMEs). In this paper, known amounts of AN will be deposited using an inkjet printer into several different common material surfaces (e.g., wood, human hair, textiles, metals, plastics). The materials are characterized with microscope images and by collecting Raman spectral data. In this report the detection and identification of AN will be demonstrated. C1 [Farrell, Mikella E.; Holthoff, Ellen L.; Pellegrino, Paul M.] US Army Res Labs, RDRL SEE E, Adelphi, MD 21228 USA. RP Farrell, ME (reprint author), US Army Res Labs, RDRL SEE E, 2800 Powder Mill Rd, Adelphi, MD 21228 USA. NR 97 TC 0 Z9 0 U1 3 U2 13 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-570-4 J9 PROC SPIE PY 2015 VL 9454 AR 94540T DI 10.1117/12.2176553 PG 13 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA BC9OO UT WOS:000356708000026 ER PT S AU Green, K Geyer, C Burnette, C Agarwal, S Swett, B Phan, C Deterline, D AF Green, Kevin Geyer, Chris Burnette, Chris Agarwal, Sanjeev Swett, Bruce Phan, Chung Deterline, Diane BE Bishop, SS Isaacs, JC TI Near Real-Time, On-The-Move Software PED using VPEF SO DETECTION AND SENSING OF MINES, EXPLOSIVE OBJECTS, AND OBSCURED TARGETS XX SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Detection and Sensing of Mines, Explosive Objects, and Obscured Targets XX CY APR 20-23, 2015 CL Baltimore, MD SP SPIE DE Near Real-Time; PED; Full-Motion Video; Mine Detection; Computer Vision; Route Clearance Package; Sensor Systems; Algorithms AB The scope of the Micro-Cloud for Operational, Vehicle-Based EO-IR Reconnaissance System (MOVERS) development effort, managed by the Night Vision and Electronic Sensors Directorate (NVESD), is to develop, integrate, and demonstrate new sensor technologies and algorithms that improve improvised device/mine detection using efficient and effective exploitation and fusion of sensor data and target cues from existing and future Route Clearance Package (RCP) sensor systems. Unfortunately, the majority of forward looking Full Motion Video (FMV) and computer vision processing, exploitation, and dissemination (PED) algorithms are often developed using proprietary, incompatible software. This makes the insertion of new algorithms difficult due to the lack of standardized processing chains. In order to overcome these limitations, EOIR developed the Government off-the-shelf (GOTS) Video Processing and Exploitation Framework (VPEF) to be able to provide standardized interfaces (e.g., input/output video formats, sensor metadata, and detected objects) for exploitation software and to rapidly integrate and test computer vision algorithms. EOIR developed a vehicle-based computing framework within the MOVERS and integrated it with VPEF. VPEF was further enhanced for automated processing, detection, and publishing of detections in near real-time, thus improving the efficiency and effectiveness of RCP sensor systems. C1 [Green, Kevin; Geyer, Chris; Burnette, Chris; Swett, Bruce; Deterline, Diane] EOIR Technol Inc, Fredericksburg, VA 22408 USA. [Agarwal, Sanjeev; Phan, Chung] US Army RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA. RP Green, K (reprint author), EOIR Technol Inc, 10300 Spotsylvania Ave,Suite 420, Fredericksburg, VA 22408 USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-570-4 J9 PROC SPIE PY 2015 VL 9454 AR 94540O DI 10.1117/12.2177750 PG 12 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA BC9OO UT WOS:000356708000021 ER PT S AU Heinz, DC Brennan, ML Steer, MB Melber, AW Cua, JT AF Heinz, Daniel C. Brennan, Michael L. Steer, Michael B. Melber, Adam W. Cua, John T. BE Bishop, SS Isaacs, JC TI Phase Response of High to Very High Frequency Metal/Anomaly Detector SO DETECTION AND SENSING OF MINES, EXPLOSIVE OBJECTS, AND OBSCURED TARGETS XX SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Detection and Sensing of Mines, Explosive Objects, and Obscured Targets XX CY APR 20-23, 2015 CL Baltimore, MD SP SPIE DE Detector; High Frequency; Very High Frequency; Metal; Anomaly; Phase AB In this paper the phase response and reflection coefficient notch of a metal/anomaly detector design that operates in the high to very high frequency range is studied. This design uses a high-Q tuned loop antenna for metal/anomaly detection. By measuring the reflection coefficient or voltage standing wave ratio a frequency notch can be detected. Tuning to the optimal location for detector performance can be accomplished by monitoring both the depth of the notch and the phase response. It has been experimentally observed that there are three regions of interest relative to the notch and phase response of the detector. One is at the frequency where the phase response is on a near vertical line of substantial phase shift and the notch is near its deepest depth. The second and third are at slightly higher and lower frequencies, where the slope of the phase shift line is reduced and the notch is still deep, but slightly removed from the frequency of maximum depth. As would be expected, initial experimentation indicates that the region of maximum detection performance, in terms of relative change in phase response, occurs when the phase response is at the center of the near vertical phase shift response near the location of the deepest notch. However, there may be advantages to the other two regions, since the response is more stable and less prone to false alarms. Performance results for various combinations of phase response and notch depth will be shown. C1 [Heinz, Daniel C.; Melber, Adam W.; Cua, John T.] US Army, CERDEC Intelligence & Informat Warfare Directorat, ATTN RDER IWI IT, Aberdeen Proving Ground, MD 21005 USA. [Brennan, Michael L.] CACI Int Inc, Aberdeen Proving Ground, MD 21005 USA. [Steer, Michael B.] N Carolina State Univ, Raleigh, NC 27606 USA. RP Heinz, DC (reprint author), US Army, CERDEC Intelligence & Informat Warfare Directorat, ATTN RDER IWI IT, Bldg 6003, Aberdeen Proving Ground, MD 21005 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-570-4 J9 PROC SPIE PY 2015 VL 9454 AR 94540H DI 10.1117/12.2182083 PG 7 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA BC9OO UT WOS:000356708000014 ER PT S AU Ling, B Agarwal, S Olivera, S Vasilkoski, Z Phan, C Geyer, C AF Ling, Bo Agarwal, Sanjeev Olivera, Santiago Vasilkoski, Zlatko Phan, Chung Geyer, Chris BE Bishop, SS Isaacs, JC TI Real-Time Buried Threat Detection and Cueing Capability in VPEF Environment SO DETECTION AND SENSING OF MINES, EXPLOSIVE OBJECTS, AND OBSCURED TARGETS XX SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Detection and Sensing of Mines, Explosive Objects, and Obscured Targets XX CY APR 20-23, 2015 CL Baltimore, MD SP SPIE DE buried threat detection; false alarm mitigation; target track; GStreamer plugin; VPEF AB In this paper, we present a vehicular buried threat detection approach developed over the past several years, and its latest implementation and integration in VPEF environment. Buried threats have varying signatures under different operation environment. To reliably detect the true targets and minimizing the number of false alarms, a suite of false alarm mitigators (FAMs) have been developed to process the potential targets identified by the baseline module. A vehicle track can be formed over a number of frames and targets are further analyzed both spatially and temporally. Algorithms have been implemented in C/C++ as GStreamer plugins and are suitable for vehicle mounted, on-the-move realtime exploitation. C1 [Ling, Bo; Olivera, Santiago; Vasilkoski, Zlatko] Migma Syst Inc, Walpole, MA 02081 USA. [Agarwal, Sanjeev; Phan, Chung] US Army RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA. [Geyer, Chris] EOIR Technol Inc, Fredricksburg, VA 22408 USA. RP Ling, B (reprint author), Migma Syst Inc, 1600 Providence Highway, Walpole, MA 02081 USA. NR 12 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-570-4 J9 PROC SPIE PY 2015 VL 9454 AR 94540P DI 10.1117/12.2177743 PG 14 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA BC9OO UT WOS:000356708000022 ER PT S AU Luke, RH Bishop, SS Chan, AM Gugino, PM Donzelli, TP Soumekh, M AF Luke, Robert H. Bishop, Steven S. Chan, Aaron M. Gugino, Peter M. Donzelli, Thomas P. Soumekh, Mehrdad BE Bishop, SS Isaacs, JC TI A Synthetic Aperture Acoustic Prototype System SO DETECTION AND SENSING OF MINES, EXPLOSIVE OBJECTS, AND OBSCURED TARGETS XX SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Detection and Sensing of Mines, Explosive Objects, and Obscured Targets XX CY APR 20-23, 2015 CL Baltimore, MD SP SPIE DE acoustic imaging; aero-acoustic sonar; side scanning synthetic aperture acoustic; SAA AB A novel quasi-monostatic system operating in a side-scan synthetic aperture acoustic (SAA) imaging mode is presented. This research project's objectives are to explore the military utility of outdoor continuous sound imaging of roadside foliage and target detection. The acoustic imaging method has several military relevant advantages such as being immune to RF jamming, superior spatial resolution as compared to 0.8-2.4 GHz ground penetrating radar (GPR), capable of standoff side and forward-looking scanning, and relatively low cost, weight and size when compared to GPR technologies. The prototype system's broadband 2-17 kHz LFM chirp transceiver is mounted on a manned all-terrain vehicle. Targets are positioned within the acoustic main beam at slant ranges of two to seven meters and on surfaces such as dirt, grass, gravel and weathered asphalt and with an intervening metallic chain link fence. Acoustic image reconstructions and signature plots result in means for literal interpretation and quantifiable analyses. C1 [Luke, Robert H.; Bishop, Steven S.; Chan, Aaron M.; Gugino, Peter M.; Donzelli, Thomas P.] US Army, RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA. [Soumekh, Mehrdad] Soumekh Consultant, Bethesda, MD USA. RP Luke, RH (reprint author), US Army, RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA. EM Robert.h.luke2.civ@mail.mil NR 4 TC 0 Z9 0 U1 2 U2 3 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-570-4 J9 PROC SPIE PY 2015 VL 9454 AR 94540Y DI 10.1117/12.2177457 PG 8 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA BC9OO UT WOS:000356708000031 ER PT S AU Shaw, D Ho, KC Stone, K Keller, JM Popescu, M Anderson, DT Luke, RH Burns, B AF Shaw, Darren Ho, K. C. Stone, Kevin Keller, James M. Popescu, Mihail Anderson, Derek T. Luke, Robert H. Burns, Brian BE Bishop, SS Isaacs, JC TI Explosive Hazard Detection Using MIMO Forward-Looking Ground Penetrating Radar SO DETECTION AND SENSING OF MINES, EXPLOSIVE OBJECTS, AND OBSCURED TARGETS XX SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Detection and Sensing of Mines, Explosive Objects, and Obscured Targets XX CY APR 20-23, 2015 CL Baltimore, MD SP SPIE DE Forward-looking explosive hazards detection; ground-penetrating radar; Support Vector Machine; spectral features; log-Gabor ID LOG-GABOR FILTERS; LANDMINE DETECTION AB This paper proposes a machine learning algorithm for subsurface object detection on multiple-input-multiple-output (MIMO) forward-looking ground-penetrating radar (FLGPR). By detecting hazards using FLGPR, standoff distances of up to tens of meters can be acquired, but this is at the degradation of performance due to high false alarm rates. The proposed system utilizes an anomaly detection prescreener to identify potential object locations. Alarm locations have multiple one-dimensional (ML) spectral features, two-dimensional (2D) spectral features, and log-Gabor statistic features extracted. The ability of these features to reduce the number of false alarms and increase the probability of detection is evaluated for both co-polarizations present in the Akela MIMO array. Classification is performed by a Support Vector Machine (SVM) with lane-based cross-validation for training and testing. Class imbalance and optimized SVM kernel parameters are considered during classifier training. C1 [Shaw, Darren; Ho, K. C.; Stone, Kevin; Keller, James M.; Popescu, Mihail] Univ Missouri, ECE Dept, Columbia, MO 65211 USA. [Anderson, Derek T.] Mississippi State Univ, ECE Dept, Starkville, MS 39762 USA. [Luke, Robert H.; Burns, Brian] US Army, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA 22060 USA. RP Shaw, D (reprint author), Univ Missouri, ECE Dept, Columbia, MO 65211 USA. NR 23 TC 1 Z9 1 U1 10 U2 14 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-570-4 J9 PROC SPIE PY 2015 VL 9454 AR 94540Z DI 10.1117/12.2177468 PG 14 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA BC9OO UT WOS:000356708000032 ER PT S AU Jahnke, JP Mackie, DM Benyamin, M Ganguli, R Sumner, JJ AF Jahnke, Justin P. Mackie, David M. Benyamin, Marcus Ganguli, Rahul Sumner, James J. BE Dhar, NK Dutta, AK TI Performance study of sugar-yeast-ethanol bio-hybrid fuel cells SO ENERGY HARVESTING AND STORAGE: MATERIALS, DEVICES, AND APPLICATIONS VI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Energy Harvesting and Storage - Materials, Devices, and Applications VI CY APR 21, 2015 CL Baltimore, MD SP SPIE DE fuel cell; DAFC; PEM; yeast; waste-to-energy; renewable energy; biomass; bio-hybrid AB Renewable alternatives to fossil hydrocarbons for energy generation are of general interest for a variety of political, economic, environmental, and practical reasons. In particular, energy from biomass has many advantages, including safety, sustainability, and the ability to be scavenged from native ecosystems or from waste streams. Microbial fuel cells (MFCs) can take advantage of microorganism metabolism to efficiently use sugar and other biomolecules as fuel, but are limited by low power densities. In contrast, direct alcohol fuel cells (DAFCs) take advantage of proton exchange membranes (PEMs) to generate electricity from alcohols at much higher power densities. Here, we investigate a novel bio-hybrid fuel cell design prepared using commercial off-the-shelf DAFCs. In the bio-hybrid fuel cells, biomass such as sugar is fermented by yeast to ethanol, which can be used to fuel a DAFC. A separation membrane between the fermentation and the DAFC is used to purify the fermentate while avoiding any parasitic power losses. However, shifting the DAFCs from pure alcohol-water solutions to filtered fermented media introduces complications related to how the starting materials, fermentation byproducts, and DAFC waste products affect both the fermentation and the long-term DAFC performance. This study examines the impact of separation membrane pore size, fermentation/fuel cell byproducts, alcohol and salt concentrations, and load resistance on fuel cell performance. Under optimized conditions, the performance obtained is comparable to that of a similar DAFC run with a pure alcohol-water mixture. Additionally, the modified DAFC can provide useable amounts of power for weeks. C1 [Jahnke, Justin P.; Mackie, David M.; Benyamin, Marcus; Sumner, James J.] US Army Res Lab, Adelphi, MD 20783 USA. [Ganguli, Rahul] Teledyne Sci & Imaging LLC, Thousand Oaks, CA 91360 USA. RP Jahnke, JP (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM justin.jahnke2.ctr@mail.mil NR 13 TC 0 Z9 0 U1 2 U2 7 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-609-1 J9 PROC SPIE PY 2015 VL 9493 AR 949303 DI 10.1117/12.2176465 PG 8 WC Energy & Fuels; Engineering, Electrical & Electronic; Optics; Physics, Applied SC Energy & Fuels; Engineering; Optics; Physics GA BC9LM UT WOS:000356606000002 ER PT S AU Prasad, N Nemir, D Beck, J Maddux, J Taylor, P AF Prasad, Narasimha Nemir, David Beck, Jan Maddux, Jay Taylor, Patrick BE Dhar, NK Dutta, AK TI Inhomogeneous Thermoelectric Materials: Improving Overall zT by Localized Property Variations SO ENERGY HARVESTING AND STORAGE: MATERIALS, DEVICES, AND APPLICATIONS VI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Energy Harvesting and Storage - Materials, Devices, and Applications VI CY APR 21, 2015 CL Baltimore, MD SP SPIE DE Thermoelectric measurements; Seebeck coefficient; Peltier effect; thermal conductivity; isothermal ID PERFORMANCE; ALLOYS AB The search for improved thermoelectric materials is driven in part by the desire to convert otherwise wasted low-temperature heat into useful electricity. In this work, we demonstrate a new path towards materials having higher overall zT, and consequently improved capacity to obtain more electrical power from a given content of heat. We produced alloys of (Bi,Sb)(2)Te-3 using a special gas atomization process that is capable of producing source powder material having nanometer-scale grain size. When impulse-compacted by shockwave consolidation, the obtained dense solid will retain its nanostructure because insufficient time and temperature are available for the kinetics of any appreciable grain growth to proceed. However, if there is initial non-uniformity in the properties of the source powder, or if there is stress non-symmetries during shockwave consolidation, then the obtained consolidated material may have locally inhomogeneous properties distributed throughout the material. Thermoelectric property measurements from selected regions within the consolidated sample indicate a wide distribution of properties. For example, the thermal conductivity at room temperature ranged from as low as 1.30 Watts/m-K in one region to higher than 3.00 Watts/m-K in a neighboring region. The electrical resistivity showed similar variation from as low as 0.5 m Omega-cm to as high as 1.5 m Omega-cm. Individually, those regions exhibited thermoelectric material figure-of-merit, zT values ranging between 0.3 and 0.4. However, when combined into a dense nanocomposite, the overall ensemble zT approaches 0.7 which is nearly a factor of 2 higher. C1 [Prasad, Narasimha] NASA, Langley Res Ctr, Hampton, VA 23681 USA. [Nemir, David; Beck, Jan] TXL Grp Inc, El Paso, TX 79903 USA. [Maddux, Jay; Taylor, Patrick] US Army Res Lab, Adelphi, MD 20783 USA. RP Prasad, N (reprint author), NASA, Langley Res Ctr, 5 N Dryden St,MS 468, Hampton, VA 23681 USA. EM narasimha.s.prasad@nasa.gov NR 12 TC 1 Z9 1 U1 0 U2 3 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-609-1 J9 PROC SPIE PY 2015 VL 9493 AR 949305 DI 10.1117/12.2181143 PG 7 WC Energy & Fuels; Engineering, Electrical & Electronic; Optics; Physics, Applied SC Energy & Fuels; Engineering; Optics; Physics GA BC9LM UT WOS:000356606000004 ER PT S AU Burks, SD Haefner, DP Burks, TJ AF Burks, Stephen D. Haefner, David P. Burks, Thomas J. BE Holst, GC Krapels, KA TI Signal intensity transfer function determination on thermal systems with stray light or scattering present SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and Testing XXVI CY APR 21-23, 2015 CL Baltimore, MD SP SPIE DE SITF; Signal Intensity Transfer Function; 3D Noise; LWIR; MWIR; Undersampled Imaging Systems AB Accurate Signal Intensity Transfer Functions (SITF) measurements are necessary to determine the calibration factor in the 3D noise calculation of an electro-optical imaging system. The typical means for measuring a sensor's SITF is to place the sensor in a flooded field environment at a distance that is relatively close to the aperture of the emitter. Unfortunately, this arrangement has the potential to allow for additional contributions to the SITF in the form of scattering or stray light if the optics are not designed properly in the system under test. Engineers at the US Army Night Vision and Electronic Sensors Directorate are working to determine a means of evaluating the contribution due to scatting or stray light. C1 [Burks, Stephen D.; Haefner, David P.] US Army, RDECOM CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. [Burks, Thomas J.] Matthew Maury Elementary Sch, Alexandria, VA 22301 USA. RP Burks, SD (reprint author), US Army, RDECOM CERDEC, Night Vis & Elect Sensors Directorate, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. NR 4 TC 0 Z9 0 U1 2 U2 3 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-568-1 J9 PROC SPIE PY 2015 VL 9452 AR 945206 DI 10.1117/12.2178150 PG 10 WC Engineering, Electrical & Electronic; Optics; Imaging Science & Photographic Technology SC Engineering; Optics; Imaging Science & Photographic Technology GA BC9NS UT WOS:000356673800005 ER PT S AU Burks, SD Doe, JM Teaney, BP AF Burks, Stephen D. Doe, Joshua M. Teaney, Brian P. BE Holst, GC Krapels, KA TI Validating Machine Vision MRT performance against trained observer performance for linear shift invariant sensors SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and Testing XXVI CY APR 21-23, 2015 CL Baltimore, MD SP SPIE DE Minimum Resolvable Temperature Difference; MRT; MRTD; LWIR; MWIR; Undersampled Imaging Systems AB Researchers at the US Army Night Vision and Electronic Sensors Directorate have added the functionality of Machine Vision MRT (MV-MRT) to the NVLabCap software package. While the original calculations of MV-MRT were compared to human observers performance using digital imagery in a previous effort,1 the technical approach was not tested on 8-bit imagery using a variety of sensors in a variety of gain and level settings. Now that it is more simple to determine the MV-MRT for a sensor in multiple gain settings, it is prudent to compare the results of MV-MRT in multiple gain settings to the performance of human observers for thermal imaging systems that are linear and shift invariant. Here, a comparison of the results for a LWIR system to trained human observers is presented. C1 [Burks, Stephen D.; Doe, Joshua M.; Teaney, Brian P.] US Army, RDECOM CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Burks, SD (reprint author), US Army, RDECOM CERDEC, Night Vis & Elect Sensors Directorate, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. NR 9 TC 0 Z9 0 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-568-1 J9 PROC SPIE PY 2015 VL 9452 AR 945204 DI 10.1117/12.2178149 PG 8 WC Engineering, Electrical & Electronic; Optics; Imaging Science & Photographic Technology SC Engineering; Optics; Imaging Science & Photographic Technology GA BC9NS UT WOS:000356673800003 ER PT S AU Deaver, DM Moyer, S AF Deaver, Dawne M. Moyer, Steve BE Holst, GC Krapels, KA TI Statistical analysis for target acquisition sensor modeling experiments SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and Testing XXVI CY APR 21-23, 2015 CL Baltimore, MD SP SPIE DE sensor modeling; visual perception experiments; confidence intervals; sample size AB The U.S. Army RDECOM CERDEC NVESD Modeling and Simulation Division is charged with the development and advancement of military target acquisition models to estimate expected soldier performance when using all types of imaging sensors. Two elements of sensor modeling are (1) laboratory-based psychophysical experiments used to measure task performance and calibrate the various models and (2) field-based experiments used to verify the model estimates for specific sensors. In both types of experiments, it is common practice to control or measure environmental, sensor, and target physical parameters in order to minimize uncertainty of the physics based modeling. Predicting the minimum number of test subjects required to calibrate or validate the model should be, but is not always, done during test planning. The objective of this analysis is to develop guidelines for test planners which recommend the number and types of test samples required to yield a statistically significant result. C1 [Deaver, Dawne M.; Moyer, Steve] US Army, Res Dev & Engn Command, Commun Elect Res Dev & Engn Ctr, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Deaver, DM (reprint author), US Army, Res Dev & Engn Command, Commun Elect Res Dev & Engn Ctr, Night Vis & Elect Sensors Directorate, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-568-1 J9 PROC SPIE PY 2015 VL 9452 AR 945208 DI 10.1117/12.2177741 PG 14 WC Engineering, Electrical & Electronic; Optics; Imaging Science & Photographic Technology SC Engineering; Optics; Imaging Science & Photographic Technology GA BC9NS UT WOS:000356673800007 ER PT S AU Du Bosq, T Repasi, E AF Du Bosq, Todd Repasi, Endre BE Holst, GC Krapels, KA TI Detector Integration Time Dependent Atmospheric Turbulence Imaging Simulation SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and Testing XXVI CY APR 21-23, 2015 CL Baltimore, MD SP SPIE DE Imaging Simulation; Atmospheric Turbulence; Integration Time AB Atmospheric turbulence is a well-known phenomenon that often degrades image quality due to intensity fluctuations, distortion, and blur in electro-optic and thermal imaging systems. To properly assess the performance of an imaging system over the typical turbulence trade space, a time consuming and costly field study is often required. A fast and realistic turbulence simulation will allow the performance assessment of an imaging system under various turbulence conditions to be done as well as provide input data for the evaluation of turbulence mitigation algorithms in a cost efficient manner. The simulation is based on an empirical model with parameters derived from the first and second-order statistics of imaging distortions measured from field collected data. The dataset consists of image sequences recorded with a variable frame rate visible camera from strong to weak turbulence conditions. The simulation uses pristine, single images containing no turbulence effects as an input and produces image sequences degraded by the specified turbulence. Target range, optics diameter, wavelength, detector integration time, and the wind velocity component perpendicular to the propagation path all contribute to the severity of the atmospheric turbulence distortions and are included in the simulation. The addition of the detector integration time expands the functionality of the simulation tool to include imagers with lower frames rates. Examples are presented demonstrating the utility of the turbulence simulation. C1 [Du Bosq, Todd] US Army, RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA. [Repasi, Endre] Fraunhofer Inst Optron Syst Technol & Image Explo, D-76275 Ettlingen, Germany. RP Du Bosq, T (reprint author), US Army, RDECOM CERDEC NVESD, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. EM info@nvl.army.mil NR 13 TC 1 Z9 1 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-568-1 J9 PROC SPIE PY 2015 VL 9452 AR 94520B DI 10.1117/12.2176985 PG 13 WC Engineering, Electrical & Electronic; Optics; Imaging Science & Photographic Technology SC Engineering; Optics; Imaging Science & Photographic Technology GA BC9NS UT WOS:000356673800010 ER PT S AU Espinola, RL Leonard, KR Byrd, KA Potvin, G AF Espinola, Richard L. Leonard, Kevin R. Byrd, Kenneth A. Potvin, Guy BE Holst, GC Krapels, KA TI Atmospheric turbulence and sensor system effects on biometric algorithm performance SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and Testing XXVI CY APR 21-23, 2015 CL Baltimore, MD SP SPIE DE atmospheric turbulence; simulation; biometrics; facial recognition AB Biometric technologies composed of electro-optical/infrared (EO/IR) sensor systems and advanced matching algorithms are being used in various force protection/security and tactical surveillance applications. To date, most of these sensor systems have been widely used in controlled conditions with varying success (e.g., short range, uniform illumination, cooperative subjects). However the limiting conditions of such systems have yet to be fully studied for long range applications and degraded imaging environments. Biometric technologies used for long range applications will invariably suffer from the effects of atmospheric turbulence degradation. Atmospheric turbulence causes blur, distortion and intensity fluctuations that can severely degrade image quality of electro-optic and thermal imaging systems and, for the case of biometrics technology, translate to poor matching algorithm performance. In this paper, we evaluate the effects of atmospheric turbulence and sensor resolution on biometric matching algorithm performance. We use a subset of the Facial Recognition Technology (FERET) database and a commercial algorithm to analyze facial recognition performance on turbulence degraded facial images. The goal of this work is to understand the feasibility of long-range facial recognition in degraded imaging conditions, and the utility of camera parameter trade studies to enable the design of the next generation biometrics sensor systems. C1 [Espinola, Richard L.; Leonard, Kevin R.; Byrd, Kenneth A.] US Army, RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA. [Potvin, Guy] DRDC Valcartier Res Ctr, Quebec City, PQ, Canada. RP Espinola, RL (reprint author), US Army, RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA. NR 16 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-568-1 J9 PROC SPIE PY 2015 VL 9452 AR 94520D DI 10.1117/12.2177800 PG 10 WC Engineering, Electrical & Electronic; Optics; Imaging Science & Photographic Technology SC Engineering; Optics; Imaging Science & Photographic Technology GA BC9NS UT WOS:000356673800012 ER PT S AU Friedman, M AF Friedman, Melvin BE Holst, GC Krapels, KA TI Investigating the Validity of the Networked Imaging Sensor Model SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and Testing XXVI CY APR 21-23, 2015 CL Baltimore, MD SP SPIE AB The Networked Imaging Sensor (NIS) model takes as input target acquisition probability as a function of time for individuals or individual imaging sensors, and outputs target acquisition probability for a collection of imaging sensors and individuals. System target acquisition takes place the moment the first sensor or individual acquires the target. The derivation of the NIS model implies it is applicable to multiple moving sensors and targets. The principal assumption of the NIS model is independence of events that give rise to input target acquisition probabilities. For investigating the validity of the NIS model, we consider a collection of single images where neither the sensor nor target is moving. This paper investigates the ability of the NIS model to predict system target acquisition performance when multiple observers view first and second Gen thermal imagery, field-of-view imagery that has either zero or one stationary target in a laboratory environment when observers have a maximum of 12, 17 or unlimited seconds to acquire the target. Modeled and measured target acquisition performance are in good agreement. C1 US Army, RDECOM, Commun Elect Res Dev & Engn Ctr, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Friedman, M (reprint author), US Army, RDECOM, Commun Elect Res Dev & Engn Ctr, Night Vis & Elect Sensors Directorate, Ft Belvoir, Ft Belvoir, VA 22060 USA. EM info@nvl.army.mil NR 14 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-568-1 J9 PROC SPIE PY 2015 VL 9452 AR 94520R DI 10.1117/12.2178418 PG 52 WC Engineering, Electrical & Electronic; Optics; Imaging Science & Photographic Technology SC Engineering; Optics; Imaging Science & Photographic Technology GA BC9NS UT WOS:000356673800025 ER PT S AU Furxhi, O Driggers, RG Preece, B Krapels, K AF Furxhi, Orges Driggers, Ronald G. Preece, Bradley Krapels, Keith BE Holst, GC Krapels, KA TI Modeling Analysis Metrics for Panoramic Sensors SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and Testing XXVI CY APR 21-23, 2015 CL Baltimore, MD SP SPIE DE panoramic; infrared; military vehicles; military requirements AB Panoramic infrared imaging is relatively new and has many applications to include tower mounted security systems, shipboard protection, and platform situational awareness. In this paper, we review metrics and methods that can be used for analysis of requirements for an infrared panoramic imaging system for military vehicles. We begin with a broad view of general military requirements organized into three categories, survivability, mobility, and lethality. A few requirements for the sensor modes of operation across all categories are selected so that panoramic system design can address as many needs as possible, but with affordability applied to system design. Metrics and associated methods that can translate military operational requirements into panoramic imager requirements are discussed in detail in this paper. C1 [Furxhi, Orges; Driggers, Ronald G.] St Johns Opt Syst, Lake Mary, FL 32746 USA. [Preece, Bradley; Krapels, Keith] US Army, RDECOM CERDEC Night Vis & Elect Sensors Direct, Modeling & Simulat Div, Ft Belvoir, VA 22060 USA. RP Furxhi, O (reprint author), St Johns Opt Syst, 1130 Business Ctr Dr, Lake Mary, FL 32746 USA. EM orges.furxhi@stjohnsopticalsystems.com NR 8 TC 0 Z9 0 U1 1 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-568-1 J9 PROC SPIE PY 2015 VL 9452 AR 945209 DI 10.1117/12.2179740 PG 12 WC Engineering, Electrical & Electronic; Optics; Imaging Science & Photographic Technology SC Engineering; Optics; Imaging Science & Photographic Technology GA BC9NS UT WOS:000356673800008 ER PT S AU Haefner, DP Teaney, BP Burks, SD AF Haefner, David P. Teaney, Brian P. Burks, Stephen D. BE Holst, GC Krapels, KA TI Blackbox Imager Characterization, from Measurements to Modeling Range Performance SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and Testing XXVI CY APR 21-23, 2015 CL Baltimore, MD SP SPIE DE System characterization; Modeling system performance; MTF measurement; Photon Transfer AB Typically, the modeling of linear and shift-invariant (LSI) imaging systems requires a complete description of each sub-component in order to estimate the final system transfer function. To validate the modeled behavior, measurements are performed on each component. When dealing with packaged systems, there are many situations where some, if not all, data is unknown. For these cases, the system is considered a blackbox, and system level measurements are used to estimate the transfer characteristics in order to model performance. This correspondence outlines the blackbox measured system component in the Night Vision Integrated Performance Model (NV-IPM). We describe how estimates of performance can be achieved with complete or incomplete measurements and how assumptions affect the final range. The blackbox measured component is the final output of a measurement characterization and is used to validate performance of delivered and prototype systems. C1 [Haefner, David P.; Teaney, Brian P.; Burks, Stephen D.] US Army, RDECOM CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Haefner, DP (reprint author), US Army, RDECOM CERDEC, Night Vis & Elect Sensors Directorate, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-568-1 J9 PROC SPIE PY 2015 VL 9452 AR 945202 DI 10.1117/12.2180386 PG 8 WC Engineering, Electrical & Electronic; Optics; Imaging Science & Photographic Technology SC Engineering; Optics; Imaging Science & Photographic Technology GA BC9NS UT WOS:000356673800001 ER PT S AU Hodgkin, VA AF Hodgkin, Van A. BE Holst, GC Krapels, KA TI Contrast Performance Modeling of Broadband Reflective Imaging Systems with Hypothetical Tunable Filter Fore-Optics SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and Testing XXVI CY APR 21-23, 2015 CL Baltimore, MD SP SPIE DE Reflective imaging; image contrast; spectral contrast; hyperspectral; target discrimination AB Most mass-produced, commercially available and fielded military reflective imaging systems operate across broad swaths of the visible, near infrared (NIR), and shortwave infrared (SWIR) wavebands without any spectral selectivity within those wavebands. In applications that employ these systems, it is not uncommon to be imaging a scene in which the image contrasts between the objects of interest, i.e., the targets, and the objects of little or no interest, i.e., the backgrounds, are sufficiently low to make target discrimination difficult or uncertain. This can occur even when the spectral distribution of the target and background reflectivity across the given waveband differ significantly from each other, because the fundamental components of broadband image contrast are the spectral integrals of the target and background signatures. Spectral integration by the detectors tends to smooth out any differences. Hyperspectral imaging is one approach to preserving, and thus highlighting, spectral differences across the scene, even when the waveband integrated signatures would be about the same, but it is an expensive, complex, noncompact, and untimely solution. This paper documents a study of how the capability to selectively customize the spectral width and center wavelength with a hypothetical tunable fore-optic filter would allow a broadband reflective imaging sensor to optimize image contrast as a function of scene content and ambient illumination. C1 US Army RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA. RP Hodgkin, VA (reprint author), US Army RDECOM CERDEC NVESD, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-568-1 J9 PROC SPIE PY 2015 VL 9452 AR UNSP 945216 DI 10.1117/12.2176956 PG 11 WC Engineering, Electrical & Electronic; Optics; Imaging Science & Photographic Technology SC Engineering; Optics; Imaging Science & Photographic Technology GA BC9NS UT WOS:000356673800037 ER PT S AU Howell, CL Choi, HS Reynolds, JP AF Howell, Christopher L. Choi, Hee-Sue Reynolds, Joseph P. BE Holst, GC Krapels, KA TI Face Acquisition Camera Design Using the NV-IPM Image Generation Tool SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and Testing XXVI CY APR 21-23, 2015 CL Baltimore, MD SP SPIE DE NV-IPM; Image Generation; Sensor Performance; Facial Recognition ID RANGE AB In this paper, we demonstrate the utility of the Night Vision Integrated Performance Model (NV-IPM) image generation tool by using it to create a database of face images with controlled degradations. Available face recognition algorithms can then be used to directly evaluate camera designs using these degraded images. By controlling camera effects such as blur, noise, and sampling, we can analyze algorithm performance and establish a more complete performance standard for face acquisition cameras. The ability to accurately simulate imagery and directly test with algorithms not only improves the system design process but greatly reduces development cost. C1 [Howell, Christopher L.; Choi, Hee-Sue; Reynolds, Joseph P.] US Army, RDECOM, CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Howell, CL (reprint author), US Army, RDECOM, CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-568-1 J9 PROC SPIE PY 2015 VL 9452 AR UNSP 94520T DI 10.1117/12.2179619 PG 10 WC Engineering, Electrical & Electronic; Optics; Imaging Science & Photographic Technology SC Engineering; Optics; Imaging Science & Photographic Technology GA BC9NS UT WOS:000356673800027 ER PT S AU Kaur, B Olson, JT Hixson, JG Richardson, PI Flug, EA AF Kaur, Balvinder Olson, Jeff T. Hixson, Jonathan G. Richardson, Philip I. Flug, Eric A. BE Holst, GC Krapels, KA TI Characterizing a High Resolution Color Display Performance using a Prichard Photometer SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and Testing XXVI CY APR 21-23, 2015 CL Baltimore, MD SP SPIE DE Cathode Ray Tube (CRT); Liquid Crystal Display (LCD); Photometer; High Resolution Monitors; Minimum Resolvable Temperature (MRT); Contrast Threshold Function (CTF) ID LIQUID-CRYSTAL DISPLAY; IMAGE QUALITY; LCD; TFT; CRT; GAMMA AB Measuring the performance of a cathode ray tube (CRT) or liquid crystal display (LCD) is necessary to enable end-to-end system modeling and characterization of currently used high performance analog imaging systems, such as 2nd Generation FLIR systems. If the display is color, the performance measurements are made more difficult because of the underlying structure of the color pixel as compared to a monochrome pixel. Out of the various characteristics of interest, we focus on determining the gamma value of a display. Gamma quantifies the non-linear response between the input gray scale and the displayed luminance. If the displayed image can be corrected for the display's gamma, an accurate scene can be presented or characterized for laboratory measurements such as MRT (Minimum Resolvable Temperature) and CTF (Contrast Threshold Function). In this paper, we present a method to determine the gamma to characterize a color display using the Prichard 1980A photometer. Gamma corrections were applied to the test images for validating the accuracy of the computed gamma value. The method presented here is a simple one easily implemented employing a Prichard photometer. C1 [Kaur, Balvinder; Olson, Jeff T.; Hixson, Jonathan G.; Richardson, Philip I.; Flug, Eric A.] US Army, RDECOM CERDEC, NVESD, Ft Belvoir, VA 22060 USA. RP Kaur, B (reprint author), US Army, RDECOM CERDEC, NVESD, Ft Belvoir, VA 22060 USA. NR 26 TC 0 Z9 0 U1 0 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-568-1 J9 PROC SPIE PY 2015 VL 9452 AR 945203 DI 10.1117/12.2177888 PG 12 WC Engineering, Electrical & Electronic; Optics; Imaging Science & Photographic Technology SC Engineering; Optics; Imaging Science & Photographic Technology GA BC9NS UT WOS:000356673800002 ER PT S AU Moyer, S Uhl, ER AF Moyer, Steve Uhl, Elizabeth R. BE Holst, GC Krapels, KA TI Block randomization versus complete randomization of human perception stimuli: Is there a difference? SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and Testing XXVI CY APR 21-23, 2015 CL Baltimore, MD SP SPIE AB For more than 50 years, the U.S. Army RDECOM CERDEC Night Vision and Electronic Sensors Directorate (NVESD) has been studying and modeling the human visual discrimination process as it pertains to military imaging systems. In order to develop sensor performance models, human observers are trained to expert levels in the identification of military vehicles. From 1998 until 2006, the experimental stimuli were block randomized, meaning that stimuli with similar difficulty levels (for example, in terms of distance from target, blur, noise, etc.) were presented together in blocks of approximately 24 images but the order of images within the block was random. Starting in 2006, complete randomization came into vogue, meaning that difficulty could change image to image. It was thought that this would provide a more statistically robust result. In this study we investigated the impact of the two types of randomization on performance in two groups of observers matched for skill to create equivalent groups. It is hypothesized that Soldiers in the Complete Randomized condition will have to shift their decision criterion more frequently than Soldiers in the Block Randomization group and this shifting is expected to impede performance so that Soldiers in the Block Randomized group perform better. C1 [Moyer, Steve] US Army, RDECOM CERDEC Night Vis Elect Sensors Dir, Ft Belvoir, VA 22060 USA. [Uhl, Elizabeth R.] Army Res Inst, Ft Benning, GA USA. RP Moyer, S (reprint author), US Army, RDECOM CERDEC Night Vis Elect Sensors Dir, Ft Belvoir, VA 22060 USA. NR 9 TC 0 Z9 0 U1 2 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-568-1 J9 PROC SPIE PY 2015 VL 9452 AR UNSP 94520M DI 10.1117/12.2177803 PG 9 WC Engineering, Electrical & Electronic; Optics; Imaging Science & Photographic Technology SC Engineering; Optics; Imaging Science & Photographic Technology GA BC9NS UT WOS:000356673800021 ER PT S AU Olson, RF AF Olson, Richard F., Jr. BE Holst, GC Krapels, KA TI Computing the total atmospheric refraction for real-time optical imaging sensor simulation SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and Testing XXVI CY APR 21-23, 2015 CL Baltimore, MD SP SPIE DE Refraction; Snell's Law; Atmospheric Modeling; Atmospheric Optics; Sensor Simulation; Hardware-in-the-Loop; IR Scene Generation AB Fast and accurate computation of light path deviation due to atmospheric refraction is an important requirement for real-time simulation of optical imaging sensor systems. A large body of existing literature covers various methods for application of Snell's Law to the light path ray tracing problem. This paper provides a discussion of the adaptation to real time simulation of atmospheric refraction ray tracing techniques used in mid-1980's LOWTRAN releases. The refraction ray trace algorithm published in a LOWTRAN-6 technical report by Kneizys (et. al.) has been coded in MATLAB for development, and in C-language for simulation use. To this published algorithm we have added tuning parameters for variable path segment lengths, and extensions for Earth grazing and exoatmospheric "near Earth" ray paths. Model atmosphere properties used to exercise the refraction algorithm were obtained from tables published in another LOWTRAN-6 related report. The LOWTRAN-6 based refraction model is applicable to atmospheric propagation at wavelengths in the IR and visible bands of the electromagnetic spectrum. It has been used during the past two years by engineers at the U.S. Army Aviation and Missile Research, Development and Engineering Center (AMRDEC) in support of several advanced imaging sensor simulations. Recently, a faster (but sufficiently accurate) method using Gauss-Chebyshev Quadrature integration for evaluating the refraction integral was adopted. C1 US Army, AMRDEC, Air & Missile Def Simulat SSDD, Redstone Arsenal, AL 35898 USA. RP Olson, RF (reprint author), US Army, AMRDEC, Air & Missile Def Simulat SSDD, Redstone Arsenal, AL 35898 USA. NR 12 TC 0 Z9 0 U1 0 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-568-1 J9 PROC SPIE PY 2015 VL 9452 AR 945211 DI 10.1117/12.2179771 PG 16 WC Engineering, Electrical & Electronic; Optics; Imaging Science & Photographic Technology SC Engineering; Optics; Imaging Science & Photographic Technology GA BC9NS UT WOS:000356673800033 ER PT S AU Preece, B Du Bosq, T Namazi, N Nehmetallah, G Kelly, KF AF Preece, Bradley Du Bosq, Todd Namazi, Nader Nehmetallah, Georges Kelly, Kevin F. BE Holst, GC Krapels, KA TI A Noise Model for the Design of a Compressive Sensing Imaging System SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and Testing XXVI CY APR 21-23, 2015 CL Baltimore, MD SP SPIE AB The design and modeling of compressive sensing (CS) imagers is difficult due to the complexity and non-linearity of the system and reconstruction algorithm. The Night Vision Integrated Performance Model (NV-IPM) is a linear imaging system design tool that is very useful for complex system trade studies. The custom component generator, included in NV-IPM, will be used to include a recently published theory for CS that links measurement noise, easily calculated with NV-IPM, to the noise of the reconstructed CS image given the estimated sparsity of the scene and the number of measurements as input. As the sparsity will also depend on other factors such as the optical transfer function and the scene content, an empirical relationship will be developed between the linear model within NV-IPM and the non-linear reconstruction algorithm using measured test data. Using the theory, a CS imager varying the number of measurements will be compared to a notional traditional imager. C1 [Preece, Bradley; Du Bosq, Todd] US Army, RDECOM CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. [Namazi, Nader; Nehmetallah, Georges] Catholic Univ Amer, Washington, DC 20064 USA. [Kelly, Kevin F.] Rice Univ, Houston, TX 77005 USA. RP Preece, B (reprint author), US Army, RDECOM CERDEC, Night Vis & Elect Sensors Directorate, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. NR 14 TC 1 Z9 1 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-568-1 J9 PROC SPIE PY 2015 VL 9452 AR 94520L DI 10.1117/12.2177275 PG 11 WC Engineering, Electrical & Electronic; Optics; Imaging Science & Photographic Technology SC Engineering; Optics; Imaging Science & Photographic Technology GA BC9NS UT WOS:000356673800020 ER PT S AU Preece, B Tomkinson, D Reynolds, J AF Preece, Bradley Tomkinson, Dave Reynolds, Joseph BE Holst, GC Krapels, KA TI An Independent Survey of Monochrome and Color Low Light Level TV Cameras SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and Testing XXVI CY APR 21-23, 2015 CL Baltimore, MD SP SPIE AB Using the latest models from the U.S. Army Night Vision Electronic Sensors Directorate (NVESD), a survey of monochrome and color imaging systems at daylight and low light levels is conducted. Each camera system is evaluated and compared under several different assumptions, such as equivalent field of view with equal and variable f/#, common lens focal length and aperture, with high dynamic range comparisons and over several light levels. The modeling is done by use of the Targeting Task Performance (TTP) metric using the latest version of the Night Vision Integrated Performance Model ((NVIPM)-I-8). The comparison is performed over the V parameter, the main output of the TTP metric. Probability of identification (PID) versus range predictions are a direct non-linear mapping of the V parameter as a function of range. Finally, a comparison between the performance of a Bayer-filtered color camera, the Bayer-filtered color camera with the IR block filter removed, and a monochrome version of the same camera is also conducted. C1 [Preece, Bradley; Tomkinson, Dave; Reynolds, Joseph] US Army, RDECOM CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Preece, B (reprint author), US Army, RDECOM CERDEC, Night Vis & Elect Sensors Directorate, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. NR 9 TC 0 Z9 0 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-568-1 J9 PROC SPIE PY 2015 VL 9452 AR UNSP 94520I DI 10.1117/12.2179623 PG 13 WC Engineering, Electrical & Electronic; Optics; Imaging Science & Photographic Technology SC Engineering; Optics; Imaging Science & Photographic Technology GA BC9NS UT WOS:000356673800017 ER PT S AU Teaney, BP Reynolds, JP Du Bosq, TW Repasi, E AF Teaney, Brian P. Reynolds, Joseph P. Du Bosq, Todd W. Repasi, Endre BE Holst, GC Krapels, KA TI A TRM4 component for the Night Vision Integrated Performance Model (NV-IPM) SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and Testing XXVI CY APR 21-23, 2015 CL Baltimore, MD SP SPIE AB The Thermal Range Model (TRM4)(1) developed by the Fraunhofer IOSB of Germany is a commonly used performance model for military target acquisition systems. There are many similarities between the U.S Army Night Vision Integrated Performance Model (NV-IPM)(2) and TRM4. Almost all of the camera performance characterizations, such as signal-to-noise calculations and modulation transfer theory are identical, only the human vision model and performance metrics differ. Utilizing the new Custom Component Generator in the NV-IPM we develop a component to calculate the Average Modulation at Optimal Phase (AMOP) and Minimum Difference Signal Perceived (MDSP) calculations used in TRM4. The results will be compared with the actual TRM4 results for a variety of imaging systems. This effort demonstrates that the NV-IPM is a versatile system design tool which can easily be extended to include a variety of image quality and performance metrics. C1 [Teaney, Brian P.; Reynolds, Joseph P.; Du Bosq, Todd W.] US Army, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. [Repasi, Endre] Fraunhofer Inst Optron Syst Technol & Image Explo, D-76275 Ettlingen, Germany. RP Teaney, BP (reprint author), US Army, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. NR 6 TC 0 Z9 0 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-568-1 J9 PROC SPIE PY 2015 VL 9452 AR 94520H DI 10.1117/12.2180002 PG 10 WC Engineering, Electrical & Electronic; Optics; Imaging Science & Photographic Technology SC Engineering; Optics; Imaging Science & Photographic Technology GA BC9NS UT WOS:000356673800016 ER PT S AU Teaney, BP Haefner, DP Burks, SD AF Teaney, Brian P. Haefner, David P. Burks, Stephen D. BE Holst, GC Krapels, KA TI Custom Component Generation in the Night Vision Integrated Performance Model SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and Testing XXVI CY APR 21-23, 2015 CL Baltimore, MD SP SPIE AB The latest version of the U.S. Army imager performance model, the Night, Vision Integrated Performance Model (NV-IPM), is HOW contained within a single, system engineering Oriented design environment. This new model interface allows sensor systems to be represented using modular, reusable components. A new feature, added in version 1.3 of the NV-IPM, allows users to create custom components which can be incorporated into modeled systems. The ability to modify existing component definitions and create entirely new components in the model greatly enhances the extensibility of the model architecture. In this paper we will discuss the structure of the custom component and parameter generators and provide several examples where this feature can be used to easily create new and unique component definitions within the model. C1 [Teaney, Brian P.; Haefner, David P.; Burks, Stephen D.] US Army, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Teaney, BP (reprint author), US Army, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-568-1 J9 PROC SPIE PY 2015 VL 9452 AR UNSP 94520Q DI 10.1117/12.2180249 PG 12 WC Engineering, Electrical & Electronic; Optics; Imaging Science & Photographic Technology SC Engineering; Optics; Imaging Science & Photographic Technology GA BC9NS UT WOS:000356673800024 ER PT S AU Teaney, BP Tomkinson, DM Hixson, JG AF Teaney, Brian P. Tomkinson, David M. Hixson, Jonathan G. BE Holst, GC Krapels, KA TI Legacy modeling and range prediction comparison: NV-IPM versus SSCamIP and NVTherm SO INFRARED IMAGING SYSTEMS: DESIGN, ANALYSIS, MODELING, AND TESTING XXVI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Infrared Imaging Systems - Design, Analysis, Modeling, and Testing XXVI CY APR 21-23, 2015 CL Baltimore, MD SP SPIE AB NVESDs new integrated sensor performance model, NV-IPM, replaces the discrete spectral band models that preceded it (NVTherm, SSCamIP, etc.). Many advanced modeling functions are now more readily available, easier to implement, and integrated within a single model architecture. For the legacy model user with ongoing modeling duties, however, the conversion of legacy decks to NV-IPM is of more immediate concern than mastering the many "power features" now available. This paper addresses the processes for the legacy model user to make a smooth transition to NV-IPM, including the conversion of legacy sensor decks to NV-IPM format decks, differences in parameters entered in the new versus old model, and a comparison of the predicted performance differences between NV-IPM and legacy models. Examples are presented to demonstrate the ease of sensor deck conversion from legacy models and to highlight enhanced model capabilities available with minimal transition effort. C1 [Teaney, Brian P.; Tomkinson, David M.; Hixson, Jonathan G.] US Army, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Teaney, BP (reprint author), US Army, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. NR 10 TC 1 Z9 1 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-568-1 J9 PROC SPIE PY 2015 VL 9452 AR 94520P DI 10.1117/12.2179371 PG 12 WC Engineering, Electrical & Electronic; Optics; Imaging Science & Photographic Technology SC Engineering; Optics; Imaging Science & Photographic Technology GA BC9NS UT WOS:000356673800023 ER PT B AU Debboun, M Frances, SP Strickman, DA AF Debboun, Mustapha Frances, Stephen P. Strickman, Daniel A. BE Debboun, M Frances, SP Strickman, DA TI Insect Repellents Handbook Preface SO INSECT REPELLENTS HANDBOOK, 2ND EDITION LA English DT Editorial Material; Book Chapter C1 [Debboun, Mustapha] US Army Med Dept Ctr & Sch, Dept Prevent Hlth Serv, Ft Sam Houston, TX 78234 USA. [Frances, Stephen P.] Australian Army Malaria Inst, Gallipoli Barracks Enogg, Qld, Australia. [Strickman, Daniel A.] ARS, George Washington Carver Ctr, USDA, Beltsville, MD USA. RP Debboun, M (reprint author), US Army Med Dept Ctr & Sch, Dept Prevent Hlth Serv, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-5358-3; 978-1-4665-5355-2 PY 2015 BP XI EP XI PG 1 WC Entomology SC Entomology GA BC7MS UT WOS:000355003300001 ER PT B AU Rutledge, LC Mehr, ZA Debboun, M AF Rutledge, Louis C. Mehr, Zia A. Debboun, Mustapha BE Debboun, M Frances, SP Strickman, DA TI Testing Methods for Insect Repellents SO INSECT REPELLENTS HANDBOOK, 2ND EDITION LA English DT Article; Book Chapter ID TOPICAL MOSQUITO REPELLENTS; SYSTEM; ATTRACTANTS; BLOOD; MODEL C1 [Rutledge, Louis C.] US Army, Mill Valley, CA USA. [Debboun, Mustapha] US Army Med Dept Ctr & Sch, Dept Prevent Hlth Serv, Ft Sam Houston, TX USA. NR 71 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-5358-3; 978-1-4665-5355-2 PY 2015 BP 159 EP 178 PG 20 WC Entomology SC Entomology GA BC7MS UT WOS:000355003300009 ER PT B AU Debboun, M Paluch, G Lindsay, D AF Debboun, Mustapha Paluch, Gretchen Lindsay, David BE Debboun, M Frances, SP Strickman, DA TI Use of Chemical Mixtures as Insecticides and Repellents SO INSECT REPELLENTS HANDBOOK, 2ND EDITION LA English DT Article; Book Chapter ID AEDES-AEGYPTI DIPTERA; INOPHYLLUM NUT OIL; ARMATUM SEED OIL; MOSQUITO-REPELLENT; MALARIA VECTORS; STOMOXYS-CALCITRANS; PERSONAL PROTECTION; ENHANCED REPELLENCY; FIELD CONDITIONS; BINARY-MIXTURES C1 [Debboun, Mustapha] US Army Med Dept Ctr & Sch, Dept Prevent Hlth Serv, Ft Sam Houston, TX 78234 USA. RP Debboun, M (reprint author), US Army Med Dept Ctr & Sch, Dept Prevent Hlth Serv, Ft Sam Houston, TX 78234 USA. NR 56 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-5358-3; 978-1-4665-5355-2 PY 2015 BP 283 EP 290 PG 8 WC Entomology SC Entomology GA BC7MS UT WOS:000355003300016 ER PT B AU Qualls, WA Xue, RD Beier, JC Debboun, M AF Qualls, Whitney A. Xue, Rui-De Beier, John C. Debboun, Mustapha BE Debboun, M Frances, SP Strickman, DA TI Alterations of Blood-Feeding Behavior and Repellent Response of Pathogen-Infected Biting Flies SO INSECT REPELLENTS HANDBOOK, 2ND EDITION LA English DT Article; Book Chapter ID AEDES-AEGYPTI DIPTERA; LA-CROSSE VIRUS; SINDBIS VIRUS; DENGUE VIRUS; PLASMODIUM-FALCIPARUM; DEET REPELLENCY; CULICIDAE; MOSQUITO; ALBOPICTUS; VECTOR C1 [Qualls, Whitney A.; Beier, John C.] Univ Miami Miller Sch Med, Dept Publ Hlth Sci, Miami, FL 33199 USA. [Xue, Rui-De] Anastasia Mosquito Control Dist, St Augustine, FL USA. [Debboun, Mustapha] US Army Med Dept Ctr & Sch, Dept Prevent Hlth Serv, Ft Sam Houston, TX USA. RP Qualls, WA (reprint author), Univ Miami Miller Sch Med, Dept Publ Hlth Sci, Miami, FL 33199 USA. NR 25 TC 0 Z9 0 U1 1 U2 1 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-5358-3; 978-1-4665-5355-2 PY 2015 BP 351 EP 356 PG 6 WC Entomology SC Entomology GA BC7MS UT WOS:000355003300021 ER PT B AU Xue, RD Muller, GC Debboun, M AF Xue, Rui-De Muller, Gunter C. Debboun, Mustapha BE Debboun, M Frances, SP Strickman, DA TI Insect Repellents for Other Potential Use SO INSECT REPELLENTS HANDBOOK, 2ND EDITION LA English DT Article; Book Chapter ID AEDES-AEGYPTI L; OVIPOSITION DETERRENTS; CULEX-QUINQUEFASCIATUS; LABORATORY EVALUATION; ANOPHELES-QUADRIMACULATUS; MOSQUITO OVIPOSITION; LARVICIDAL ACTIVITY; DIPTERA-CULICIDAE; FIELD-EVALUATION; ESSENTIAL OILS C1 [Xue, Rui-De] Anastasia Mosquito Control Dist, St Augustine, FL 32080 USA. [Muller, Gunter C.] Hebrew Univ Jerusalem, Dept Microbiol & Mol, Jerusalem, Israel. [Debboun, Mustapha] US Army Med Dept Ctr & Sch, Dept Prevent Hlth Serv, Ft Sam Houston, TX USA. RP Xue, RD (reprint author), Anastasia Mosquito Control Dist, St Augustine, FL 32080 USA. NR 29 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-5358-3; 978-1-4665-5355-2 PY 2015 BP 357 EP 365 PG 9 WC Entomology SC Entomology GA BC7MS UT WOS:000355003300022 ER PT B AU Debboun, M Frances, SP Strickman, D AF Debboun, Mustapha Frances, Stephen P. Strickman, Daniel BE Debboun, M Frances, SP Strickman, DA TI Future of Insect Repellents SO INSECT REPELLENTS HANDBOOK, 2ND EDITION LA English DT Article; Book Chapter C1 [Debboun, Mustapha] US Army Med Dept Ctr & Sch, Dept Prevent Hlth Serv, Ft Sam Houston, TX 78234 USA. [Frances, Stephen P.] Australian Army Malaria Inst, Gallipoli Barracks Enogg, Qld, Australia. [Strickman, Daniel] ARS, George Washington Carver Ctr, USDA, Beltsville, MD USA. RP Debboun, M (reprint author), US Army Med Dept Ctr & Sch, Dept Prevent Hlth Serv, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-5358-3; 978-1-4665-5355-2 PY 2015 BP 367 EP 369 PG 3 WC Entomology SC Entomology GA BC7MS UT WOS:000355003300023 ER PT S AU Krych, DE Lange-Maney, S McDaniel, P Glodek, W AF Krych, Daniel E. Lange-Maney, Stephen McDaniel, Patrick Glodek, William BE Kelmelis, EJ TI Investigating Weaknesses in Android Certificate Security SO MODELING AND SIMULATION FOR DEFENSE SYSTEMS AND APPLICATIONS X SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Modeling and Simulation for Defense Systems and Applications X CY APR 21, 2015 CL Baltimore, MD SP SPIE DE Android; Android Security; Android Certificate; RSA AB Android's application market relies on secure certificate generation to establish trust between applications and their users; yet, cryptography is often not a priority for application developers and many fail to take the necessary security precautions. Indeed, there is cause for concern: several recent high-profile studies have observed a pervasive lack of entropy on Web-systems leading to the factorization of private keys.(1) Sufficient entropy, or randomness, is essential to generate secure key pairs and combat predictable key generation. In this paper, we analyze the security of Android certificates. We investigate the entropy present in 550,000 Android application certificates using the Quasilinear CCD finding algorithm.(1) Our results show that while the lack of entropy does not appear to be as ubiquitous in the mobile markets as on Web-systems, there is substantial reuse of certificatesonly one third of the certificates in our dataset were unique. In other words, we find that organizations frequently reuse certificates for different applications. While such a practice is acceptable under Google's specifications for a single developer, we find that in some cases the same certificates are used for a myriad of developers, potentially compromising Android's intended trust relationships. Further, we observed duplicate certificates being used by both malicious and non-malicious applications. The top 3 repeated certificates present in our dataset accounted for a total of 11,438 separate APKs. Of these applications, 451, or roughly 4%, were identified as malicious by antivirus services. C1 [Krych, Daniel E.; Lange-Maney, Stephen; McDaniel, Patrick] Penn State Univ, Dept Comp Sci & Engn, University Pk, PA 16802 USA. [Glodek, William] US Army, Res Lab, Adelphi, MD USA. RP Krych, DE (reprint author), Penn State Univ, Dept Comp Sci & Engn, University Pk, PA 16802 USA. EM dek5156@cse.psu.edu; mcdaniel@cse.psu.edu; william.j.glodek.civ@mail.mil NR 9 TC 0 Z9 0 U1 1 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-594-0 J9 PROC SPIE PY 2015 VL 9478 AR 947804 DI 10.1117/12.2177498 PG 9 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA BC9NT UT WOS:000356674500002 ER PT S AU Poshtyar, A Elangovan, V Shirkhodaie, A Chan, A Hu, SW AF Poshtyar, Azin Elangovan, Vinayak Shirkhodaie, Amir Chan, Alex Hu, Shuowen BE Kelmelis, EJ TI Physical Environment Virtualization for Human Activities Recognition SO MODELING AND SIMULATION FOR DEFENSE SYSTEMS AND APPLICATIONS X SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Modeling and Simulation for Defense Systems and Applications X CY APR 21, 2015 CL Baltimore, MD SP SPIE DE Group Activity Modeling; Group Activity Recognition; Virtual Environment Modeling and Simulation; Virtual Sensors Modeling; Large-Scale System Modeling AB Human activity recognition research relies heavily on extensive datasets to verify and validate performance of activity recognition algorithms. However, obtaining real datasets are expensive and highly time consuming. A physics-based virtual simulation can accelerate the development of context based human activity recognition algorithms and techniques by generating relevant training and testing videos simulating diverse operational scenarios. In this paper, we discuss in detail the requisite capabilities of a virtual environment to aid as a test bed for evaluating and enhancing activity recognition algorithms. To demonstrate the numerous advantages of virtual environment development, a newly developed virtual environment simulation modeling (VESM) environment is presented here to generate calibrated multi-source imagery datasets suitable for development and testing of recognition algorithms for context-based human activities. The VESM environment serves as a versatile test bed to generate a vast amount of realistic data for training and testing of sensor processing algorithms. To demonstrate the effectiveness of VESM environment, we present various simulated scenarios and processed results to infer proper semantic annotations from the high fidelity imagery data for human-vehicle activity recognition under different operational contexts. C1 [Poshtyar, Azin; Elangovan, Vinayak; Shirkhodaie, Amir] Tennessee State Univ, Dept Mech & Mfg Engn, Ctr Excellence Battlefield Senor Fus, Nashville, TN 37209 USA. [Chan, Alex; Hu, Shuowen] US Army, Image Proc Branch, Res Lab, Adelphi, MD 20783 USA. RP Poshtyar, A (reprint author), Tennessee State Univ, Dept Mech & Mfg Engn, Ctr Excellence Battlefield Senor Fus, 3500 John Merritt Blvd, Nashville, TN 37209 USA. NR 13 TC 0 Z9 0 U1 0 U2 3 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-594-0 J9 PROC SPIE PY 2015 VL 9478 AR 94780I DI 10.1117/12.2178547 PG 12 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA BC9NT UT WOS:000356674500012 ER PT S AU Moulton, CL Krzywicki, AT Hepp, JJ Harrell, J Kogut, M AF Moulton, Christine L. Krzywicki, Alan T. Hepp, Jared J. Harrell, John Kogut, Michael BE Suresh, R TI Open architecture design and approach for the Integrated Sensor Architecture (ISA) SO OPEN ARCHITECTURE/OPEN BUSINESS MODEL NET-CENTRIC SYSTEMS AND DEFENSE TRANSFORMATION 2015 SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Open Architecture/Open Business Model Net-Centric Systems and Defense Transformation CY APR 21-23, 2015 CL Baltimore, MD SP SPIE DE Open Architecture; Service Oriented Architecture AB Integrated Sensor Architecture (ISA) is designed in response to stovepiped integration approaches. The design, based on the principles of Service Oriented Architectures (SOA) and Open Architectures, addresses the problem of integration, and is not designed for specific sensors or systems. The use of SOA and Open Architecture approaches has led to a flexible, extensible architecture. Using these approaches, and supported with common data formats, open protocol specifications, and Department of Defense Architecture Framework (DoDAF) system architecture documents, an integration-focused architecture has been developed. ISA can help move the Department of Defense (DoD) from costly stovepipe solutions to a more cost-effective plug-and-play design to support interoperability. C1 [Moulton, Christine L.; Krzywicki, Alan T.] US Army, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA 22060 USA. [Hepp, Jared J.; Harrell, John] Oakwood Controls Corp, Glen Rock, PA USA. [Kogut, Michael] SAIC, Mclean, VA USA. RP Moulton, CL (reprint author), US Army, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA 22060 USA. NR 10 TC 0 Z9 0 U1 2 U2 3 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-595-7 J9 PROC SPIE PY 2015 VL 9479 AR 94790C DI 10.1117/12.2177842 PG 6 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA BC9NW UT WOS:000356675900006 ER PT S AU Slocum, DM Goyette, TM Giles, RH Nixon, WE AF Slocum, David M. Goyette, Thomas M. Giles, Robert H. Nixon, William E. BE Anwar, MF Crowe, TW Manzur, T TI Experimental determination of terahertz atmospheric absorption parameters SO TERAHERTZ PHYSICS, DEVICES, AND SYSTEMS IX: ADVANCED APPLICATIONS IN INDUSTRY AND DEFENSE SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Terahertz Physics, Devices, and Systems IX - Advanced Applications in Industry and Defense CY APR 22-23, 2015 CL Baltimore, MD SP SPIE DE water vapor; methanol; continuum; terahertz; spectroscopy; multispectral fitting ID WATER-VAPOR CONTINUUM; FOURIER-TRANSFORM SPECTROMETER; RESOLVED EXPERIMENTAL SPECTRUM; SOUTHEASTERN UNITED-STATES; METHYL ALCOHOL; METHANOL CH3OH; MAUNA-KEA; SUBMILLIMETER; LINE; GHZ AB The terahertz frequency regime is often used as the 'chemical fingerprint' region of the electromagnetic spectrum since many molecules exhibit a dense selection of rotational and vibrational transitions. Water is a major component of the atmosphere and since it has a large dipole moment the propagation of terahertz radiation will be dominated by atmospheric effects. This study will present the results of high-resolution broadband measurements of the terahertz atmospheric absorption and detail the technique for directly measuring the pressure broadening coefficients, absolute absorption coefficients, line positions, and continuum effects. Differences between these measured parameters and those tabulated in HITRAN will be discussed. Once the water vapor absorption was characterized, the same technique was used to measure the line parameters for methanol, a trace gas of interest within Earth's atmosphere. Methanol has a dense absorption spectrum in the terahertz frequency region and is an important molecule in fields such as environmental monitoring, security, and astrophysics. The data obtained in the present study will be of immediate use for the remote sensing community, as it is uncommon to measure this many independent parameters as well as to measure the absolute absorption of the transitions. Current models rely on tabulated databases of calculated values for the line parameters measured in this study. Differences between the measured data and those in the databases will be highlighted and discussed. C1 [Slocum, David M.; Goyette, Thomas M.; Giles, Robert H.] Univ Massachusetts, Submillimeter Wave Technol Lab, Lowell, MA 01854 USA. [Nixon, William E.] US Army, Natl Ground Intelligence Ctr, Charlottesville, VA 22911 USA. RP Slocum, DM (reprint author), Univ Massachusetts, Submillimeter Wave Technol Lab, Lowell, MA 01854 USA. EM David_Slocum@student.uml.edu NR 41 TC 0 Z9 0 U1 0 U2 4 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-599-5 J9 PROC SPIE PY 2015 VL 9483 AR 94830O DI 10.1117/12.2176455 PG 12 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BC9TK UT WOS:000356865100013 ER PT S AU Fu, C Arguello, H Sadler, BM Arce, GR AF Fu, Chen Arguello, Henry Sadler, Brain M. Arce, Gonzalo R. BE Ahmad, F TI Compressive Spectral Polarization Imaging With Coded Micropolarizer Array SO COMPRESSIVE SENSING IV SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Compressive Sensing IV CY APR 22-24, 2015 CL Baltimore, MD SP SPIE DE Compressive sensing; Spectral and polarization imaging; Rotating prism ID POLARIMETRY AB We present a compressive spectral polarization imager based on a prism which is rotated to different angles as the measurement shots are taken, and a colored detector with a micropolarizer array. The prism shears the scene along one spatial axis according to its wavelength components. The scene is then projected to different locations on the detector as measurement shots are taken. Composed of 0, 45, 90, 135 linear micropolarizers, the pixels of the micropolarizer array matched to that of the colored detector, thus the first three Stokes parameters of the scene are compressively sensed. The four dimensional (4D) data cube is thus projected onto the two dimensional (2D) FPA. Designed patterns for the micropolarizer and the colored detector are applied so as to improve the reconstruction problem. The 4D spectral-polarization data cube is reconstructed from the 2D measurements via nonlinear optimization with sparsity constraints. Computer simulations are performed and the performance of designed patterns is compared with random patterns. C1 [Fu, Chen; Arce, Gonzalo R.] Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA. [Arguello, Henry] Univ Ind Santander, Bucaramanga, Colombia. [Sadler, Brain M.] AMSRL CI CN, Army Res Lab, Adelphi, MD 20783 USA. RP Fu, C (reprint author), Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA. NR 9 TC 0 Z9 0 U1 1 U2 7 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-600-8 J9 PROC SPIE PY 2015 VL 9484 DI 10.1117/12.2177813 PG 7 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BC9MK UT WOS:000356619200007 ER PT J AU Grujicic, M Ramaswami, S Snipes, J Galgalikar, R Yavari, R Yen, CF Cheeseman, B Montgomery, J AF Grujicic, Mica Ramaswami, Subrahmanian Snipes, Jennifer Galgalikar, Rohan Yavari, Ramin Yen, Chian-Fong Cheeseman, Bryan Montgomery, Jonathan TI Modeling of ballistic-failure mechanisms in gas metal arc welds of mil a46100 armor-grade steel SO ENGINEERING COMPUTATIONS LA English DT Article DE MIL A46100 armor-grade steel; Ballistic limit; Gas metal arc welding (GMAW) Process modeling ID AA5083-H116 ALUMINUM PLATES; STAINLESS-STEEL; PROJECTILES; PERFORATION; EVOLUTION; REAUSTENITIZATION; MICROSTRUCTURE; PERFORMANCE AB Purpose - The purpose of this paper is to discuss the recently developed multi-physics computational model for the conventional Gas Metal Arc Welding (GMAW) joining process that has been upgraded with respect to its predictive capabilities regarding the spatial distribution of the mechanical properties controlling the ballistic limit (i.e. penetration resistance) of the weld. Design/methodology/approach - The original model consists of five modules, each dedicated to handling a specific aspect of the GMAW process, i.e.: electro-dynamics of the welding-gun; radiation-/convection-controlled heat transfer from the electric arc to the workpiece and mass transfer from the filler-metal consumable electrode to the weld; prediction of the temporal evolution and the spatial distribution of thermal and mechanical fields within the weld region during the GMAW joining process; the resulting temporal evolution and spatial distribution of the material microstructure throughout the weld region; and spatial distribution of the as-welded material mechanical properties. The model is upgraded through the introduction of the sixth module in the present work in recognition of the fact that in thick steel GMAW weldments, the overall ballistic performance of the armor may become controlled by the (often inferior) ballistic limits of its weld (fusion and heat-affected) zones. Findings - The upgraded GMAW process model is next applied to the case of butt-welding of MIL A46100 (a prototypical high-hardness armor-grade martensitic steel) workpieces using filler-metal electrodes made of the same material. The predictions of the upgraded GMAW process model pertaining to the spatial distribution of the material microstructure and ballistic-limit-controlling mechanical properties within the MIL A46100 butt-weld are found to be consistent with general expectations and prior observations. Originality/value - To the authors' knowledge, the present work is the first reported attempt to establish, using computational modeling, functional relationships between the GMAW process parameters and the mechanical properties controlling the ballistic limit of the resulting weld. C1 [Grujicic, Mica; Ramaswami, Subrahmanian; Snipes, Jennifer; Galgalikar, Rohan; Yavari, Ramin] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. [Yen, Chian-Fong; Cheeseman, Bryan; Montgomery, Jonathan] Army Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. EM gmica@g.clemson.edu FU Army Research Office [W911NF-11-1-0207, W911NF-11-1-0518] FX The material presented in this paper is based on work supported by two Army Research Office sponsored grants entitled "Friction Stir Welding Behavior of Selected 2000-series and 5000-series Aluminum Alloys" (Contract Number W911NF-11-1-0207), and "Concept Validation and Optimization for a Vent-based Mine-blast Mitigation System" (Contract Number W911NF-11-1-0518). The authors are indebted to Dr Ralph A. Anthenien, Jr and Dr Bryan Glaz of ARO for their continuing support and interest in the present work. NR 51 TC 1 Z9 1 U1 1 U2 7 PU EMERALD GROUP PUBLISHING LIMITED PI BINGLEY PA HOWARD HOUSE, WAGON LANE, BINGLEY BD16 1WA, W YORKSHIRE, ENGLAND SN 0264-4401 EI 1758-7077 J9 ENG COMPUTATION JI Eng. Comput. PY 2015 VL 32 IS 3 BP 705 EP 741 DI 10.1108/EC-01-2014-0010 PG 37 WC Computer Science, Interdisciplinary Applications; Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications; Mechanics SC Computer Science; Engineering; Mathematics; Mechanics GA CJ9NS UT WOS:000355829900008 ER PT J AU Tran, DT Zhang, SS AF Tran, Dat T. Zhang, Sheng S. TI Chemical stability and electrochemical characteristics of FeS microcrystals as the cathode material of rechargeable lithium batteries SO JOURNAL OF MATERIALS CHEMISTRY A LA English DT Article ID ION BATTERIES; ANODE MATERIAL; PERFORMANCE; STORAGE; NANOSTRUCTURES; ELECTROLYTE; NANOSHEETS; CHEMISTRY AB Carbon precursor coated iron monosulphide (CP@FeS) microcrystals are synthesized by a facile one-pot solvothermal reaction of FeSO4 and two moles of Na2S with sucrose as the carbon source, and evaluated as the cathode material of rechargeable lithium batteries. The results show that the obtained CP@FeS microcrystals consist of two FeS phases and contain a small amount of sulphur. In storage, FeS transforms into Fe3S4, which is further oxidized by oxygen in air to release elemental sulphur. Interestingly, such transformation and oxidation are found to affect only the first discharge voltage profile with negligible impact on the specific capacity and cycling performance of a Li/FeS battery. It is shown that the cyclability of the Li/FeS battery is greatly affected by the electrolyte solvent and charging cutoff voltage. In this paper, we discuss the chemical stability and redox mechanism of the FeS cathode material, and investigate the factors that affect the cycling performance of Li/FeS batteries. C1 [Tran, Dat T.; Zhang, Sheng S.] US Army Res Lab, Energy & Power Div, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), US Army Res Lab, Energy & Power Div, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. EM shengshui.zhang.civ@mail.mil RI Zhang, Sheng/A-4456-2012 OI Zhang, Sheng/0000-0003-4435-4110 NR 22 TC 9 Z9 9 U1 25 U2 106 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2050-7488 EI 2050-7496 J9 J MATER CHEM A JI J. Mater. Chem. A PY 2015 VL 3 IS 23 BP 12240 EP 12246 DI 10.1039/c5ta02048d PG 7 WC Chemistry, Physical; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Energy & Fuels; Materials Science GA CJ8FX UT WOS:000355736700017 ER PT S AU Edwards, E Brantley, CL Ruffin, PB Crutcher, S AF Edwards, Eugene Brantley, Christina L. Ruffin, Paul B. Crutcher, Sihon BE Varadan, VK TI Nano Devices & Concepts for Condition-Based Maintenance of Military Systems SO NANOSENSORS, BIOSENSORS, AND INFO-TECH SENSORS AND SYSTEMS 2015 SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Nanosensors, Biosensors, and Info-Tech Sensors and Systems CY MAR 09-11, 2015 CL San Diego, CA SP SPIE, American Soc Mech Engineers, Intelligent Mat Forum, Jet Propuls Lab, Natl Sci Fdn DE Nano devices; condition-based maintenance; propellant stabilizer; acoustic; spectral sensing AB There is a continuous need for the Department of Defense (DoD) and its associate weaponry supply organizations to consistently evaluate the usability of weapons that exhibit deteriorative characteristics over a period of time. Along the same lines, enhanced condition-based maintenance evaluation procedures are necessary to mitigate the risk and reduce the cost of catastrophic failure of varying inventories of military systems. One significant area of research is the verification of the existence of sufficient concentrations of propellant stabilizer in the motor of stored missiles. Results from developed apparatuses can help collect degradation information to establish indicators that the missile's double-based solid propellant is still functional after long-term storage. Other mechanisms are being developed for the assessment of degradation in gun barrel rifling. The research outlined in this paper summarizes the Army Aviation and Missile Research, Development, & Engineering Center's (AMRDEC's) investigative approaches relative to the use of spectral-optical and acoustical methodologies for detecting deteriorations in both propellant and the apparatus that engages munitions. A spectral-optical sensing approach is presented that is based on distinctive light collecting optical fiber -based developments designed to detect the concentration of propellant ingredients. The use of diagnostic acoustic sensing mechanisms is delineated to include the use of commercially available transducer-based readers to collect information that is indicative of the distance that acoustic waves travel through weaponry components. In collaboration with several AMRDEC industry and academia supporters, this paper outlines sensing methods that are under consideration for implementation onto weapon systems. Conceptional approaches, experimental configurations, and laboratory results are presented for each initiative. Cost-savings and improved weaponry health monitoring capabilities are expected to derive from each sensing mechanisms. C1 [Edwards, Eugene; Brantley, Christina L.; Crutcher, Sihon] US Army Res Dev & Engn Command, Redstone Arsenal, AL 35898 USA. Alabama A&M Univ, Coll Phys Chem & Engn, Normal, AL 35811 USA. RP Edwards, E (reprint author), US Army Res Dev & Engn Command, Redstone Arsenal, AL 35898 USA. EM eugene.edwards.civ@mail.mil NR 7 TC 1 Z9 1 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-537-7 J9 PROC SPIE PY 2015 VL 9434 AR 943402 DI 10.1117/12.2084422 PG 11 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BC8PT UT WOS:000355991300001 ER PT J AU Qiu, HW Patel, RB Damavarapu, RS Stepanov, V AF Qiu, Hongwei Patel, Rajen B. Damavarapu, Reddy S. Stepanov, Victor TI Nanoscale 2CL-20.HMX high explosive cocrystal synthesized by bead milling SO CRYSTENGCOMM LA English DT Article ID SHOCK SENSITIVITY; ENERGETIC COCRYSTAL; RDX; CRYSTALS; CL-20 AB Energetic nanoscale 2CL-20.HMX, a cocrystal of CL-20 and HMX in a 2 : 1 molar ratio, was prepared by a novel method of bead milling an aqueous suspension of epsilon-CL-20 and beta-HMX. The conversion of the coformers to the cocrystal form was monitored by powder X-ray diffraction (XRD) and scanning electron microscopy (SEM) analysis of specimens sampled at various milling times. Complete conversion to the cocrystal form was achieved by 60 minutes of milling. Rounded 2CL-20.HMX cocrystal particles with a mean size below 200 nm were produced. A mechanism for the conversion of the coformers to the cocrystalline form is postulated based on the experimental results. As an inherently safe manufacturing method, the aqueous bead milling process has great potential in advancing cocrystal research and applications in the field of energetic materials. C1 [Qiu, Hongwei] Leidos Inc, Engn & Technol Solut Div, Picatinny Arsenal, NJ 07806 USA. [Patel, Rajen B.; Damavarapu, Reddy S.; Stepanov, Victor] US Army, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA. RP Qiu, HW (reprint author), Leidos Inc, Engn & Technol Solut Div, Picatinny Arsenal, NJ 07806 USA. EM rajen.b.patel.civ@mail.mil NR 27 TC 3 Z9 3 U1 8 U2 34 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1466-8033 J9 CRYSTENGCOMM JI Crystengcomm PY 2015 VL 17 IS 22 BP 4080 EP 4083 DI 10.1039/c5ce00489f PG 4 WC Chemistry, Multidisciplinary; Crystallography SC Chemistry; Crystallography GA CJ4UF UT WOS:000355481800005 ER PT J AU Gill, HS Thota, S Li, L Kokil, A Mosurkal, R Kumar, J AF Gill, Hardeep Singh Thota, Sammaiah Li, Lian Kokil, Akshay Mosurkal, Ravi Kumar, Jayant TI Performance enhancement of fullerene based solar cells upon NIR laser irradiation SO RSC ADVANCES LA English DT Article ID FILMS; POLY(3-HEXYLTHIOPHENE); P3HT/PCBM; C-60; POLYMERIZATION; NANOPARTICLES; MORPHOLOGY; EFFICIENT; ACCEPTOR; DONOR AB Photovoltaic performance enhancement of fullerene based solar cells was achieved upon exposure to near-infrared (NIR) laser pulses. The solar cells were fabricated with poly(3-hexylthiophene) (P3HT) and [6,6]-phenyl C-61-butyric acid methyl ester (PCBM) under ambient conditions. The cells were then post-treated with NIR femto-second laser pulses at 800 nm for different intervals of time. An enhancement of 50% in the power conversion efficiency was achieved for the devices with 15 minutes of NIR laser irradiation compared to that of the control device. The enhancement in the power conversion efficiency is attributed to the formation of a covalent linkage between P3HT and PCBM as suggested by Matrix-assisted laser desorption/ionization time of flight mass spectroscopic analysis on a blend of a thiophene oligomer and PCBM before and after NIR laser exposure. C1 [Gill, Hardeep Singh; Kumar, Jayant] Univ Massachusetts Lowell, Dept Phys, Lowell, MA 01854 USA. [Gill, Hardeep Singh; Thota, Sammaiah; Kokil, Akshay; Kumar, Jayant] Univ Massachusetts Lowell, Ctr Adv Mat, Lowell, MA 01854 USA. [Li, Lian; Mosurkal, Ravi] US Army, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Kumar, J (reprint author), Univ Massachusetts Lowell, Dept Phys, Lowell, MA 01854 USA. EM Lian_Li@uml.edu; Jayant_Kumar@uml.edu RI MOSURKAL, RAVI/P-6981-2015 FU Polymer-Based Materials for Harvesting Solar Energy, an Energy Frontier Research Center - U.S. Department of Energy, Office of Science, Basic Energy Sciences [DE-SC0001087]; Faculty Research Participation Program at the U.S. Army Natick Soldier Research, Development and Engineering Center (NSRDEC) FX This work was supported as part of Polymer-Based Materials for Harvesting Solar Energy, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Basic Energy Sciences under Award #DE-SC0001087. This research was also supported by in part by an appointment to the Faculty Research Participation Program at the U.S. Army Natick Soldier Research, Development and Engineering Center (NSRDEC) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and NSRDEC. NR 29 TC 1 Z9 1 U1 3 U2 5 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2046-2069 J9 RSC ADV JI RSC Adv. PY 2015 VL 5 IS 60 BP 48526 EP 48532 DI 10.1039/c5ra05640c PG 7 WC Chemistry, Multidisciplinary SC Chemistry GA CJ8GN UT WOS:000355738300044 ER PT S AU Esola, S Bartoli, I Horner, SE Zheng, JQ Kontsos, A AF Esola, S. Bartoli, I. Horner, S. E. Zheng, J. Q. Kontsos, A. BE Chimenti, DE Bond, LJ TI Parametric Study Using Modal Analysis of a Bi-Material Plate with Defects SO 41ST ANNUAL REVIEW OF PROGRESS IN QUANTITATIVE NONDESTRUCTIVE EVALUATION, VOL 34 SE AIP Conference Proceedings LA English DT Proceedings Paper CT 41st Annual Review of Progress in Quantitative Nondestructive Evaluation (QNDE) CY JUL 20-25, 2014 CL Boise, ID SP Ctr Nondestruct Evaluat, Quantitat Nondestruct Evaluat Programs, Amer Soc Nondestruct Testing, World Federat NDE Ctr, Natl Sci Fdn, Ind Univ Co Operat Res Ctr Program ID RECTANGULAR-PLATES; FREE VIBRATION; COMPOSITE; DELAMINATION; DAMAGE AB Global vibrational method feasibility as a non-destructive inspection tool for multi-layered composites is evaluated using a simulated parametric study approach. A finite element model of a composite consisting of two, isotropic layers of dissimilar materials and a third, thin isotropic layer of adhesive is constructed as the representative test subject. Next, artificial damage is inserted according to systematic variations of the defect morphology parameters. A free-vibrational modal analysis simulation is executed for pristine and damaged plate conditions. Finally, resultant mode shapes and natural frequencies are extracted, compared and analyzed for trends. Though other defect types may be explored, the focus of this research is on interfacial delamination and its effects on the global, free-vibrational behavior of a composite plate. This study is part of a multi-year research effort conducted for the U. S. Army Program Executive Office - Soldier. C1 [Esola, S.; Kontsos, A.] Drexel Univ, Dept Mech Engn & Mech, Theoret & Appl Mech Grp, Philadelphia, PA 19104 USA. [Bartoli, I.] Drexel Univ, Dept Civil Architectural & Environm Engn, Philadelphia, PA 19104 USA. [Horner, S. E.; Zheng, J. Q.] US Army, Program Execut Off Soldier, Ft Belvoir, VA 22060 USA. RP Kontsos, A (reprint author), Drexel Univ, Dept Mech Engn & Mech, Theoret & Appl Mech Grp, 3141 Chestnut St, Philadelphia, PA 19104 USA. EM akontsos@coe.drexel.edu NR 17 TC 0 Z9 0 U1 0 U2 0 PU AMER INST PHYSICS PI MELVILLE PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA SN 0094-243X BN 978-0-7354-1292-7 J9 AIP CONF PROC PY 2015 VL 1650 BP 1112 EP 1120 DI 10.1063/1.4914720 PG 9 WC Physics, Applied SC Physics GA BC7JI UT WOS:000354938100131 ER PT B AU Plaisant, C Monroe, M Meyer, T Shneiderman, B AF Plaisant, Catherine Monroe, Megan Meyer, Tamra Shneiderman, Ben BE Marconi, K Lehmann, H TI Interactive Visualization SO BIG DATA AND HEALTH ANALYTICS LA English DT Article; Book Chapter AB This chapter focuses on the central role of information visualization in health analytics. From the early x-rays to 3D volume visualizations, rapid progress has been made. However, the most exciting growth is now in the area of information visualization, which offers interactive environments and analytic processes that help support exploration of electronic health record (EHR) data, monitoring, or insight discovery. For example, a health organization might want to investigate patterns of drug prescriptions in patients with asthma and compare prescribing practices with current guidelines. Temporal patterns are critical to this analysis, and interactive visualizations are beginning to support powerful temporal queries, present rich result summaries, and offer fluid interactions to identify the clinically relevant patterns hidden in the data. Visualization should soon help clinicians identify cohorts of patients who match selection criteria for clinical trials or need to be brought back to the office. Visualization can also reveal data quality problems, which are common when repurposing clinical data for secondary analysis. After a quick summary of the state-of-the-art of information visualization systems for exploring and querying EHR data, we describe in detail one recent system (EventFlow) developed by the Human-Computer Interaction Lab at the University of Maryland and illustrate its use with an asthma prescription study example. C1 [Plaisant, Catherine; Shneiderman, Ben] Univ Maryland, Inst Adv Comp Studies, Human Comp Interact Lab, College Pk, MD 20742 USA. [Monroe, Megan] Univ Maryland, Inst Adv Comp Studies, College Pk, MD 20742 USA. [Meyer, Tamra] US Army, Off Surgeon Gen, Washington, DC 20310 USA. RP Plaisant, C (reprint author), Univ Maryland, Inst Adv Comp Studies, Human Comp Interact Lab, College Pk, MD 20742 USA. NR 20 TC 0 Z9 0 U1 0 U2 1 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-2925-7; 978-1-4822-2923-3 PY 2015 BP 243 EP 262 PG 20 WC Health Care Sciences & Services; Medical Informatics SC Health Care Sciences & Services; Medical Informatics GA BC5BP UT WOS:000353153000014 ER PT J AU Chen, J Carter, R Maoz, D Tobar, A Sharon, E Greif, F AF Chen, Jacob Carter, Robert, III Maoz, Daniel Tobar, Ana Sharon, Eran Greif, Franklin TI Breast Cancer and Sarcoidosis: Case Series and Review of the Literature SO BREAST CARE LA English DT Article DE Sarcoidosis; Breast cancer; Sarcoid-like reaction ID POSITRON-EMISSION-TOMOGRAPHY; PULMONARY SARCOIDOSIS; MAMMARY SARCOIDOSIS; MIMICKING CARCINOMA; NEEDLE-ASPIRATION; MALIGNANT TUMOURS; LYMPH-NODES; FOLLOW-UP; DIAGNOSIS; TUMORS AB Background: Sarcoidosis is a chronic inflammatory disease of unknown etiology, which can involve different organs and systems. Accordingly, sarcoidosis can mimic breast cancer, making the differential diagnosis very difficult. Case Report: 5 patients with a diagnosis of both sarcoidosis and breast cancer followed by the Rabin Medical Center between January 1993 and June 2012 were enrolled in this study. Additionally, a comprehensive literature review which identified 104 patients diagnosed with breast cancer and sarcoidosis was carried out. In both populations reviewed, the average age at diagnosis of sarcoidosis and breast cancer was 57 years. Among the 66 patients with both sarcoidosis and breast cancer, sarcoidosis preceded breast cancer in 31 cases, followed it in 23 cases, and appeared concurrently in 10 cases. Conclusion: Based on our clinical cases and literature review, a histological study is recommended over imaging if sarcoidosis or breast cancer may be present. Furthermore, breast cancer is rarely associated with sarcoidosis or sarcoidosis-like reaction. C1 [Chen, Jacob; Maoz, Daniel; Sharon, Eran; Greif, Franklin] Rabin Med Ctr, Dept Surg, IL-49100 Petah Tiqwa, Israel. [Chen, Jacob; Maoz, Daniel; Tobar, Ana; Sharon, Eran; Greif, Franklin] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel. [Chen, Jacob; Carter, Robert, III] US Army Inst Surg Res, Houston, TX USA. [Tobar, Ana] Rabin Med Ctr, Dept Pathol, IL-49100 Petah Tiqwa, Israel. RP Greif, F (reprint author), Rabin Med Ctr, Dept Surg A, Beilinson Campus 39 Jabotinsky St, IL-49100 Petah Tiqwa, Israel. EM fgreif@clalit.org.il NR 65 TC 0 Z9 0 U1 0 U2 1 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1661-3791 EI 1661-3805 J9 BREAST CARE JI Breast Care PY 2015 VL 10 IS 2 BP 137 EP 140 DI 10.1159/000381324 PG 4 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA CI8IG UT WOS:000355015300010 PM 26195943 ER PT B AU Wick, CH AF Wick, Charles H. BA Wick, CH BF Wick, CH TI Detection of Whole Viruses SO INTEGRATED VIRUS DETECTION LA English DT Article; Book Chapter C1 [Wick, Charles H.] US Army Edgewood Chem Biol Ctr ECBC, Aberdeen Proving Ground, MD USA. [Wick, Charles H.] US Army Ballist Res Lab, Vulnerabil Lethal Div, Warsaw, Poland. [Wick, Charles H.] US Army, Washington, DC USA. [Wick, Charles H.] Biol Def Syst, Washington, DC USA. [Wick, Charles H.] ECBC, DoD, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-3007-9; 978-1-4822-3005-5 PY 2015 BP 1 EP 29 PG 29 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA BC7NC UT WOS:000355008300002 ER PT B AU Wick, CH AF Wick, Charles H. BA Wick, CH BF Wick, CH TI Integrated Virus Detection Preface SO INTEGRATED VIRUS DETECTION LA English DT Article; Book Chapter ID FLIGHT MASS-SPECTROMETRY; DETECTION SYSTEM IVDS; MS2 BACTERIOPHAGE; ESCHERICHIA-COLI; MOLECULAR-WEIGHT; PROTEIN; IDENTIFICATION; PURIFICATION C1 [Wick, Charles H.] US Army Edgewood Chem Biol Ctr ECBC, Aberdeen Proving Ground, MD USA. [Wick, Charles H.] US Army Ballist Res Lab, Vulnerabil Lethal Div, Warsaw, Poland. [Wick, Charles H.] US Army, Washington, DC USA. [Wick, Charles H.] Biol Def Syst, Washington, DC USA. [Wick, Charles H.] ECBC, DoD, Washington, DC USA. NR 60 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-3007-9; 978-1-4822-3005-5 PY 2015 BP XVII EP + PG 5 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA BC7NC UT WOS:000355008300001 ER PT B AU Wick, CH AF Wick, Charles H. BA Wick, CH BF Wick, CH TI Instrumentation SO INTEGRATED VIRUS DETECTION LA English DT Article; Book Chapter C1 [Wick, Charles H.] US Army Edgewood Chem Biol Ctr ECBC, Aberdeen Proving Ground, MD USA. [Wick, Charles H.] US Army Ballist Res Lab, Vulnerabil Lethal Div, Warsaw, Poland. [Wick, Charles H.] US Army, Washington, DC USA. [Wick, Charles H.] Biol Def Syst, Washington, DC USA. [Wick, Charles H.] ECBC, DoD, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-3007-9; 978-1-4822-3005-5 PY 2015 BP 31 EP 70 PG 40 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA BC7NC UT WOS:000355008300003 ER PT B AU Wick, CH AF Wick, Charles H. BA Wick, CH BF Wick, CH TI Proof Concept Using MS2 SO INTEGRATED VIRUS DETECTION LA English DT Article; Book Chapter C1 [Wick, Charles H.] US Army Edgewood Chem Biol Ctr ECBC, Aberdeen Proving Ground, MD USA. [Wick, Charles H.] US Army Ballist Res Lab, Vulnerabil Lethal Div, Warsaw, Poland. [Wick, Charles H.] US Army, Washington, DC USA. [Wick, Charles H.] Biol Def Syst, Washington, DC USA. [Wick, Charles H.] ECBC, DoD, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-3007-9; 978-1-4822-3005-5 PY 2015 BP 71 EP 96 PG 26 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA BC7NC UT WOS:000355008300004 ER PT B AU Wick, CH AF Wick, Charles H. BA Wick, CH BF Wick, CH TI Concentration of Viruses SO INTEGRATED VIRUS DETECTION LA English DT Article; Book Chapter C1 [Wick, Charles H.] US Army Edgewood Chem Biol Ctr ECBC, Aberdeen Proving Ground, MD USA. [Wick, Charles H.] US Army Ballist Res Lab, Vulnerabil Lethal Div, Warsaw, Poland. [Wick, Charles H.] US Army, Washington, DC USA. [Wick, Charles H.] Biol Def Syst, Washington, DC USA. [Wick, Charles H.] ECBC, DoD, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-3007-9; 978-1-4822-3005-5 PY 2015 BP 97 EP 106 PG 10 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA BC7NC UT WOS:000355008300005 ER PT B AU Wick, CH AF Wick, Charles H. BA Wick, CH BF Wick, CH TI Cause and Effect Curves SO INTEGRATED VIRUS DETECTION LA English DT Article; Book Chapter C1 [Wick, Charles H.] US Army Edgewood Chem Biol Ctr ECBC, Aberdeen Proving Ground, MD USA. [Wick, Charles H.] US Army Ballist Res Lab, Vulnerabil Lethal Div, Warsaw, Poland. [Wick, Charles H.] US Army, Washington, DC USA. [Wick, Charles H.] Biol Def Syst, Washington, DC USA. [Wick, Charles H.] ECBC, DoD, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-3007-9; 978-1-4822-3005-5 PY 2015 BP 107 EP 120 PG 14 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA BC7NC UT WOS:000355008300006 ER PT B AU Wick, CH AF Wick, Charles H. BA Wick, CH BF Wick, CH TI Isolating Single Viruses from Multivirus Mixtures SO INTEGRATED VIRUS DETECTION LA English DT Article; Book Chapter C1 [Wick, Charles H.] US Army Edgewood Chem Biol Ctr ECBC, Aberdeen Proving Ground, MD USA. [Wick, Charles H.] US Army Ballist Res Lab, Vulnerabil Lethal Div, Warsaw, Poland. [Wick, Charles H.] US Army, Washington, DC USA. [Wick, Charles H.] Biol Def Syst, Washington, DC USA. [Wick, Charles H.] ECBC, DoD, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-3007-9; 978-1-4822-3005-5 PY 2015 BP 121 EP 129 PG 9 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA BC7NC UT WOS:000355008300007 ER PT B AU Wick, CH AF Wick, Charles H. BA Wick, CH BF Wick, CH TI Analyzing Various Viruses SO INTEGRATED VIRUS DETECTION LA English DT Article; Book Chapter C1 [Wick, Charles H.] US Army Edgewood Chem Biol Ctr ECBC, Aberdeen Proving Ground, MD USA. [Wick, Charles H.] US Army Ballist Res Lab, Vulnerabil Lethal Div, Warsaw, Poland. [Wick, Charles H.] US Army, Washington, DC USA. [Wick, Charles H.] Biol Def Syst, Washington, DC USA. [Wick, Charles H.] ECBC, DoD, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-3007-9; 978-1-4822-3005-5 PY 2015 BP 131 EP 163 PG 33 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA BC7NC UT WOS:000355008300008 ER PT B AU Wick, CH AF Wick, Charles H. BA Wick, CH BF Wick, CH TI Detection of Other Nanoparticles SO INTEGRATED VIRUS DETECTION LA English DT Article; Book Chapter C1 [Wick, Charles H.] US Army Edgewood Chem Biol Ctr ECBC, Aberdeen Proving Ground, MD USA. [Wick, Charles H.] US Army Ballist Res Lab, Vulnerabil Lethal Div, Warsaw, Poland. [Wick, Charles H.] US Army, Washington, DC USA. [Wick, Charles H.] Biol Def Syst, Washington, DC USA. [Wick, Charles H.] ECBC, DoD, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-3007-9; 978-1-4822-3005-5 PY 2015 BP 165 EP 173 PG 9 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA BC7NC UT WOS:000355008300009 ER PT B AU Wick, CH AF Wick, Charles H. BA Wick, CH BF Wick, CH TI Direct Counting of Pili SO INTEGRATED VIRUS DETECTION LA English DT Article; Book Chapter C1 [Wick, Charles H.] US Army Edgewood Chem Biol Ctr ECBC, Aberdeen Proving Ground, MD USA. [Wick, Charles H.] US Army Ballist Res Lab, Vulnerabil Lethal Div, Warsaw, Poland. [Wick, Charles H.] US Army, Washington, DC USA. [Wick, Charles H.] Biol Def Syst, Washington, DC USA. [Wick, Charles H.] ECBC, DoD, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-3007-9; 978-1-4822-3005-5 PY 2015 BP 175 EP 183 PG 9 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA BC7NC UT WOS:000355008300010 ER PT B AU Wick, CH AF Wick, Charles H. BA Wick, CH BF Wick, CH TI Detecting Viruses in Honeybees SO INTEGRATED VIRUS DETECTION LA English DT Article; Book Chapter C1 [Wick, Charles H.] US Army Edgewood Chem Biol Ctr ECBC, Aberdeen Proving Ground, MD USA. [Wick, Charles H.] US Army Ballist Res Lab, Vulnerabil Lethal Div, Warsaw, Poland. [Wick, Charles H.] US Army, Washington, DC USA. [Wick, Charles H.] Biol Def Syst, Washington, DC USA. [Wick, Charles H.] ECBC, DoD, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-3007-9; 978-1-4822-3005-5 PY 2015 BP 185 EP 205 PG 21 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA BC7NC UT WOS:000355008300011 ER PT B AU Wick, CH AF Wick, Charles H. BA Wick, CH BF Wick, CH TI Pulsed Lamp Decontamination SO INTEGRATED VIRUS DETECTION LA English DT Article; Book Chapter C1 [Wick, Charles H.] US Army Edgewood Chem Biol Ctr ECBC, Aberdeen Proving Ground, MD USA. [Wick, Charles H.] US Army Ballist Res Lab, Vulnerabil Lethal Div, Warsaw, Poland. [Wick, Charles H.] US Army, Washington, DC USA. [Wick, Charles H.] Biol Def Syst, Washington, DC USA. [Wick, Charles H.] ECBC, DoD, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-3007-9; 978-1-4822-3005-5 PY 2015 BP 207 EP 219 PG 13 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA BC7NC UT WOS:000355008300012 ER PT B AU Wick, CH AF Wick, Charles H. BA Wick, CH BF Wick, CH TI Current and Future Trends SO INTEGRATED VIRUS DETECTION LA English DT Article; Book Chapter C1 [Wick, Charles H.] US Army Edgewood Chem Biol Ctr ECBC, Aberdeen Proving Ground, MD USA. [Wick, Charles H.] US Army Ballist Res Lab, Vulnerabil Lethal Div, Warsaw, Poland. [Wick, Charles H.] US Army, Washington, DC USA. [Wick, Charles H.] Biol Def Syst, Washington, DC USA. [Wick, Charles H.] ECBC, DoD, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-3007-9; 978-1-4822-3005-5 PY 2015 BP 221 EP 224 PG 4 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA BC7NC UT WOS:000355008300013 ER PT J AU Hurley, RK Rivera, JC Wenke, JC Krueger, CA AF Hurley, Richard K., Jr. Rivera, Jessica C. Wenke, Joseph C. Krueger, Chad A. TI Identifying obstacles to return to duty in severely injured combat-related servicemembers with amputation SO JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT LA English DT Article DE Active Duty; amputation; combat; combat-related amputation; disability; disability rating; Injury Severity Score; physician evaluation liaison board; rehabilitation; return to duty ID TRAUMA RECOVERY PROJECT; CURRENT CONFLICTS; AMPUTEE SOLDIERS; EXTREMITY; PROSTHETICS; AFGHANISTAN; 12-MONTH; OUTCOMES; IRAQ; WAR AB The capacity of servicemembers with amputation to return to duty after combat-related amputation and the associated disabilities remains largely unknown. The purpose of this study was to examine the disabling conditions and return to duty rates of servicemembers with amputation across all service branches following major limb amputations from September 2001 through July 2011. Pertinent medical information, military occupation status, return to duty designation, disabling conditions, and disability ratings for each servicemember were obtained from the Physical Evaluation Board Liaison Office (PEBLO). Across all service branches, 16 (2%) servicemembers were found fit for duty (Fit) and allowed to continue with their preinjury occupation. Another 103 (11%) were allowed to continue on Active Duty (COAD) in a less physically demanding role. More than half (554, 56%) were determined fully disabled (PEBLO rating > 75); the average disability rating was 73. COAD and Fit Army servicemembers had lower Injury Severity Scores than other servicemembers (17.4, p = 0.009 and 11.2, p < 0.001, respectively). Despite improvements in their care and rehabilitation, only 13% of all servicemembers with amputation are able to return to Active Duty and many have multiple disabling conditions that contribute to a very high level of disability. C1 [Hurley, Richard K., Jr.] San Antonio Mil Med Ctr, Dept Orthopaed Surg, Ft Sam Houston, TX 78234 USA. [Rivera, Jessica C.; Krueger, Chad A.] San Antonio Mil Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. [Wenke, Joseph C.] US Army, Inst Surg Res, Dept Regenerat Med, Ft Sam Houston, TX 78234 USA. RP Hurley, RK (reprint author), San Antonio Mil Med Ctr, Orthopaed Surg, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM richard.k.hurley.mil@mail.mil NR 22 TC 2 Z9 2 U1 1 U2 4 PU JOURNAL REHAB RES & DEV PI BALTIMORE PA DEPT OF VETERANS AFFAIRS REHABIL RES & DEVELOP CTR 103 SOUTH GAY STREET, BALTIMORE, MD 21202-4051 USA SN 0748-7711 EI 1938-1352 J9 J REHABIL RES DEV JI J. Rehabil. Res. Dev. PY 2015 VL 52 IS 1 BP 53 EP 61 DI 10.1682/JRRD.2014.04.0094 PG 9 WC Rehabilitation SC Rehabilitation GA CI8YI UT WOS:000355057200006 PM 26230831 ER PT J AU Hohenforst-Schmidt, W Zarogoulidis, P Stopek, J Vogl, T Hubner, F Turner, JF Browning, R Zarogoulidis, K Drevelegas, A Drevelegas, K Darwiche, K Freitag, L Rittger, H AF Hohenforst-Schmidt, Wolfgang Zarogoulidis, Paul Stopek, Joshua Vogl, Thomas Hubner, Frank Turner, J. Francis Browning, Robert Zarogoulidis, Konstantinos Drevelegas, Antonis Drevelegas, Konstantinos Darwiche, Kaid Freitag, Lutz Rittger, Harald TI DDMC-p53 gene therapy with or without cisplatin and microwave ablation SO ONCOTARGETS AND THERAPY LA English DT Article DE DDMC; p53; carboplatin; microwave; non-small cell lung cancer ID CELL LUNG-CANCER; GROWTH-FACTOR RECEPTOR; RADIOFREQUENCY ABLATION; THERMAL ABLATION; INTRATUMORAL CHEMOTHERAPY; RESPIRATORY SYSTEM; AEROSOL DELIVERY; PROSTATE-CANCER; BREAST-CANCER; IN-VITRO AB Lung cancer remains the leading cause of death in cancer patients. Severe treatment side effects and late stage of disease at diagnosis continue to be an issue. We investigated whether local treatment using 2-diethylaminoethyl-dextran methyl methacrylate copolymer with p53 (DDMC-p53) with or without cisplatin and/or microwave ablation enhances disease control in BALBC mice. We used a Lewis lung carcinoma cell line to inoculate 140 BALBC mice, which were divided into the following seven groups; control, cisplatin, microwave ablation, DDMC-p53, DDMC-p53 plus cisplatin, DDMC-p53 plus microwave, and DDMC-p53 plus cisplatin plus microwave. Microwave ablation energy was administered at 20 W for 10 minutes. Cisplatin was administered as 1 mL/mg and the DDMC-p53 complex delivered was 0.5 mL. Increased toxicity was observed in the group receiving DDMC-p53 plus cisplatin plus microwave followed by the group receiving DDMC-p53 plus cisplatin. Infection after repeated treatment administration was a major issue. We conclude that a combination of gene therapy using DDMC-p53 with or without cisplatin and microwave is an alternative method for local disease control. However, more experiments are required in a larger model to identify the appropriate dosage profile. C1 [Hohenforst-Schmidt, Wolfgang; Hubner, Frank] Univ Wurzburg, Coburg Hosp, Med Clin 2, Coburg, Germany. [Zarogoulidis, Paul; Zarogoulidis, Konstantinos] Aristotle Univ Thessaloniki, Dept Pulm, Oncol Unit, G Papanikolaou Gen Hosp, GR-54006 Thessaloniki, Greece. [Stopek, Joshua] Covidien, Jersey City, NJ USA. [Vogl, Thomas] Goethe Univ Frankfurt, Dept Diagnost & Intervent Radiol, D-60054 Frankfurt, Germany. [Turner, J. Francis] Western Reg Med Ctr, Div Intervent Pulmonol, Goodyear, AZ USA. [Turner, J. Francis] Western Reg Med Ctr, Med Oncol, Canc Treatment Ctr Amer, Goodyear, AZ USA. [Browning, Robert] Walter Reed Army Med Ctr, Pulm & Crit Care Med, Intervent Pulmonol, Natl Naval Med Ctr, Bethesda, MD USA. [Drevelegas, Antonis; Drevelegas, Konstantinos] Interbalkan European Med Ctr, Dept Radiol, Thessaloniki, Greece. [Darwiche, Kaid; Freitag, Lutz] Univ Essen Duisburg, Univ Hosp Essen, Ruhrlandklin, Dept Intervent Pneumol, Essen, Germany. [Rittger, Harald] Univ Erlangen Nurnberg, Fuerth Hosp, Med Clin 1, Erlangen, Germany. RP Zarogoulidis, P (reprint author), Aristotle Univ Thessaloniki, Dept Pulm, Oncol Unit, G Papanikolaou Gen Hosp, GR-54006 Thessaloniki, Greece. EM pzarog@hotmail.com NR 83 TC 1 Z9 1 U1 2 U2 9 PU DOVE MEDICAL PRESS LTD PI ALBANY PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND SN 1178-6930 J9 ONCOTARGETS THER JI OncoTargets Ther. PY 2015 VL 8 BP 1165 EP 1173 DI 10.2147/OTT.S83794 PG 9 WC Biotechnology & Applied Microbiology; Oncology SC Biotechnology & Applied Microbiology; Oncology GA CI5HE UT WOS:000354784700001 PM 26056480 ER PT J AU Bynum, JA Rastogi, A Stavchansky, SA Bowman, PD AF Bynum, James A. Rastogi, Ashish Stavchansky, Salomon A. Bowman, Phillip D. TI Cytoprotection of Human Endothelial Cells from Oxidant Stress with CDDO Derivatives: Network Analysis of Genes Responsible for Cytoprotection SO PHARMACOLOGY LA English DT Article DE Cytoprotection; Human endothelial cells; CDDO-Im; CDDO-Me; Gene expression profiling; Oxidant stress ID ACID PHENETHYL ESTER; POTENT COMPETITIVE INHIBITOR; TIN PROTOPORPHYRIN-IX; HEME OXYGENASE-1; OXIDATIVE STRESS; 2-CYANO-3,12-DIOXOOLEAN-1,9-DIEN-28-OIC ACID; INFLAMMATORY RESPONSE; SYSTEMS PHARMACOLOGY; SPECIES GENERATION; MOUSE MACROPHAGES AB Aim:To identify drugs that may reduce the impact of oxidant stress on cell viability. Methods: Human umbilical vein endothelial cells were treated with 200 nmol/ICDDO-Im (imidazole) and CDDO-Me (methyl) after exposure to menadione and compared to vehicle-treated cells. Cell viability and cytotoxicity were assessed, and gene expression profiling was performed. Results: CDDO-Im was significantly more cytoprotective and less cytotoxic (p < 0.001) than CDDO-Me. Although both provided cytoprotection by induction of gene transcription, CDDO-lm induced more genes. In addition to a higher induction of the key cytoprotective gene heme oxygenase-1 (38.9-fold increase for CDDO-Im and 26.5-fold increase for CDDO-Me), CDDO-Im also induced greater expression of heat shock proteins (5.5-fold increase compared to 2.8-fold for CDDO-Me). Conclusions: Both compounds showed good induction of heme oxygenase, which largely accounted for their cytoprotective effect. Differences were detected in cytotoxicity at higher doses, indicating that CDDO-Me was more cytotoxic than CDDO-Im. Significant differences were detected in the ability of CDDO-Im and CDDO-Me to affect differential gene transcription. CDDO-Im induced more genes than did CDDO-Me. The source of the differences in gene expression patterns between CDDO-Im and CDDO-Me was not determined but may be important in long-term use of this class of drugs. (C) 2015 S. Karger AG, Basel C1 [Bynum, James A.; Rastogi, Ashish; Bowman, Phillip D.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Bynum, James A.; Rastogi, Ashish; Stavchansky, Salomon A.] Univ Texas Austin, Coll Pharm, Div Pharmaceut, Austin, TX 78712 USA. RP Bowman, PD (reprint author), US Army, Inst Surg Res, 3650 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM phillip.d.bowman4.vol@mail.mil NR 63 TC 1 Z9 1 U1 0 U2 1 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0031-7012 EI 1423-0313 J9 PHARMACOLOGY JI Pharmacology PY 2015 VL 95 IS 3-4 BP 181 EP 192 DI 10.1159/000381188 PG 12 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA CI3QX UT WOS:000354663600011 PM 25926128 ER PT J AU Hohenforst-Schmidt, W Linsmeier, B Zarogoulidis, P Freitag, L Darwiche, K Browning, R Turner, JF Huang, HD Li, Q Vogl, T Zarogoulidis, K Brachmann, J Rittger, H AF Hohenforst-Schmidt, Wolfgang Linsmeier, Bernd Zarogoulidis, Paul Freitag, Lutz Darwiche, Kaid Browning, Robert Turner, J. Francis Huang, Haidong Li, Qiang Vogl, Thomas Zarogoulidis, Konstantinos Brachmann, Johannes Rittger, Harald TI Transtracheal single-point stent fixation in posttracheotomy tracheomalacia under cone-beam computer tomography guidance by transmural suturing with the Berci needle - a perspective on a new tool to avoid stent migration of Dumon stents SO THERAPEUTICS AND CLINICAL RISK MANAGEMENT LA English DT Article DE stent; airway; cone-beam computer tomography; Berci needle; Dumon stents; tracheobronchomalacia ID BENIGN TRACHEOBRONCHIAL STENOSIS; POSITIVE AIRWAY PRESSURE; ELUTING TRACHEAL STENT; SILICONE STENTS; EXTERNAL FIXATION; COLLAPSE; STABILIZATION; OBSTRUCTION; OUTCOMES; ADULT AB Tracheomalacia or tracheobronchomalacia (TM or TBM) is a common problem especially for elderly patients often unfit for surgical techniques. Several surgical or minimally invasive techniques have already been described. Stenting is one option but in general long-time stenting is accompanied by a high complication rate. Stent removal is more difficult in case of self-expandable nitinol stents or metallic stents in general in comparison to silicone stents. The main disadvantage of silicone stents in comparison to uncovered metallic stents is migration and plugging. We compared the operation time and in particular the duration of a sufficient Dumon stent fixation with different techniques in a patient with severe posttracheotomy TM and strongly reduced mobility of the vocal cords due to Parkinson's disease. The combined approach with simultaneous Dumon stenting and endoluminal transtracheal externalized suture under cone-beam computer tomography guidance with the Berci needle was by far the fastest approach compared to a (not performed) surgical intervention, or even purely endoluminal suturing through the rigid bronchoscope. The duration of the endoluminal transtracheal externalized suture was between 5 minutes and 9 minutes with the Berci needle; the pure endoluminal approach needed 51 minutes. The alternative of tracheobronchoplasty was refused by the patient. In general, 180 minutes for this surgical approach is calculated. The costs of the different approaches are supposed to vary widely due to the fact that in Germany 1 minute in an operation room costs on average approximately 50-60(sic) inclusive of taxes. In our own hospital (tertiary level), it is nearly 30(sic) per minute in an operation room for a surgical approach. Calculating an additional 15 minutes for patient preparation and transfer to wake-up room, therefore a total duration inside the investigation room of 30 minutes, the cost per flexible bronchoscopy is per minute on average less than 6(sic). Although the Dumon stenting requires a set-up with more expensive anesthesiology accompaniment, which takes longer than a flexible investigation estimated at 1 hour in an operation room, still without calculation of the costs of the materials and specialized staff that the surgical approach would consume at least 3,000(sic) more than a minimally invasive approach performed with the Berci needle. This difference is due to the longer time of the surgical intervention which is calculated at approximately 180 minutes in comparison to the achieved non-surgical approach of 60 minutes in the operation suite. C1 [Hohenforst-Schmidt, Wolfgang; Rittger, Harald] Univ Erlangen Nurnberg, Fuerth Hosp, Med Clin 1, Furth, Germany. [Linsmeier, Bernd] Medinos Clin Sonneberg, Dept Thorac Surg, Sonnerberg, Germany. [Zarogoulidis, Paul; Zarogoulidis, Konstantinos] Aristotle Univ Thessaloniki, G Papanikolaou Gen Hosp, Dept Pulm, Oncol Unit, GR-54006 Thessaloniki, Greece. [Freitag, Lutz; Darwiche, Kaid] Univ Essen Duisburg, Univ Hosp Essen, Ruhrlandklin, Dept Intervent Pneumol, Essen, Germany. [Browning, Robert] Walter Reed Army Med Ctr, Natl Naval Med Ctr, Intervent Pulmonol, Pulm & Crit Care Med, Bethesda, MD USA. [Turner, J. Francis] Western Reg Med Ctr, Canc Treatment Ctr Amer, Div Intervent Pulmonol & Med Oncol, Goodyear, AZ USA. [Huang, Haidong; Li, Qiang] II Mil Univ Hosp, Shanghai Hosp, Dept Resp Dis, Shanghai, Peoples R China. [Vogl, Thomas] Goethe Univ Frankfurt, Dept Diagnost & Intervent Radiol, D-60054 Frankfurt, Germany. [Hohenforst-Schmidt, Wolfgang; Brachmann, Johannes] Univ Wurzburg, Coburg Hosp, Med Clin 2, Coburg, Germany. RP Zarogoulidis, P (reprint author), Aristotle Univ Thessaloniki, G Papanikolaou Gen Hosp, Dept Pulm, Oncol Unit, GR-54006 Thessaloniki, Greece. EM pzarog@hotmail.com FU Siemens, Germany FX Dr Wolfgang Hohenforst-Schmidt would like to thank Mr Carl Reiner for providing the Model Twinstream jet ventilator. Moreover Dr Wolfgang Hohenforst-Schmidt would like to thank Siemens, Germany for the technical and financial support that they have provided for this project. NR 50 TC 3 Z9 4 U1 0 U2 4 PU DOVE MEDICAL PRESS LTD PI ALBANY PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND SN 1178-203X J9 THER CLIN RISK MANAG JI Therap. Clin. Risk Manag. PY 2015 VL 11 BP 837 EP 850 DI 10.2147/TCRM.S83230 PG 14 WC Health Care Sciences & Services SC Health Care Sciences & Services GA CI8CR UT WOS:000354995900001 PM 26045666 ER PT J AU Dugan, HA Doran, PT Wagner, B Kenig, F Fritsen, CH Arcone, SA Kuhn, E Ostrom, NE Warnock, JP Murray, AE AF Dugan, H. A. Doran, P. T. Wagner, B. Kenig, F. Fritsen, C. H. Arcone, S. A. Kuhn, E. Ostrom, N. E. Warnock, J. P. Murray, A. E. TI Stratigraphy of Lake Vida, Antarctica: hydrologic implications of 27 m of ice SO CRYOSPHERE LA English DT Article ID MCMURDO DRY VALLEYS; SOUTHERN VICTORIA LAND; TAYLOR VALLEY; POLAR-DESERT; ISOTOPE GEOCHEMISTRY; LACUSTRINE SEDIMENTS; UNIVERSITY VALLEY; CLIMATIC-CHANGE; GROUND ICE; HOARE AB Lake Vida, located in Victoria Valley, is one of the largest lakes in the McMurdo dry valleys and is known to contain hypersaline liquid brine sealed below 16 m of freshwater ice. For the first time, Lake Vida was drilled to a depth of 27 m. Below 21 m the ice is marked by well-sorted sand layers up to 20 cm thick within a matrix of salty ice. From ice chemistry, isotopic composition of delta O-18 and delta H-2, and ground penetrating radar profiles, we conclude that the entire 27 m of ice formed from surface runoff and the sediment layers represent the accumulation of surface deposits. Radiocarbon and optically stimulated luminescence dating limit the maximum age of the lower ice to 6300 C-14 yr BP. As the ice cover ablated downwards during periods of low surface inflow, progressive accumulation of sediment layers insulated and preserved the ice and brine beneath, analogous to the processes that preserve shallow ground ice. The repetition of these sediment layers reveals hydrologic variability in Victoria Valley during the mid-to late Holocene. Lake Vida is an exemplar site for understanding the preservation of subsurface brine, ice, and sediment in a cold desert environment. C1 [Dugan, H. A.; Doran, P. T.; Kenig, F.] Univ Illinois, Dept Earth & Environm Sci, Chicago, IL 60607 USA. [Dugan, H. A.] Univ Wisconsin, Ctr Limnol, Madison, WI 53706 USA. [Wagner, B.] Univ Cologne, Inst Geol & Mineral, D-50931 Cologne, Germany. [Fritsen, C. H.; Kuhn, E.; Murray, A. E.] Univ Nevada, Desert Res Inst, Div Earth & Ecosyst Sci, Reno, NV 89506 USA. [Arcone, S. A.] US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Ostrom, N. E.] Michigan State Univ, Dept Zool, E Lansing, MI 48824 USA. [Warnock, J. P.] No Illinois Univ, Dept Geol & Environm Geosci, De Kalb, IL USA. RP Dugan, HA (reprint author), Univ Illinois, Dept Earth & Environm Sci, Chicago, IL 60607 USA. EM hilarydugan@gmail.com RI Wagner, Bernd/J-4682-2012; OI Kenig, Fabien/0000-0003-4868-5232 FU National Science Foundation [0739698, 0739681]; NASA [NNX10AN23H]; Natural Sciences and Engineering Research Council of Canada; University of Illinois at Chicago; Desert Research Institute Division of Earth and Ecosystem Sciences; Fulbright CAPES-Brazil [2163-08-8] FX This research was supported by National Science Foundation grants 0739698 and 0739681 and NASA grant NNX10AN23H. We would like to thank field team members Peter Glenday, Jay Kyne, Seth Young, and Brian Glazer and the RPSC Field Safety and Training Program, the United States Antarctic Program, and PHI helicopters. Graduate student funding to H. Dugan was assisted by the Natural Sciences and Engineering Research Council of Canada and the University of Illinois at Chicago. Graduate student funding to E. Kuhn was supported by the Desert Research Institute Division of Earth and Ecosystem Sciences and the Fulbright CAPES-Brazil grant 2163-08-8. Two anonymous reviewers significantly improved this paper. NR 68 TC 6 Z9 6 U1 1 U2 11 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY SN 1994-0416 EI 1994-0424 J9 CRYOSPHERE JI Cryosphere PY 2015 VL 9 IS 2 BP 439 EP 450 DI 10.5194/tc-9-439-2015 PG 12 WC Geography, Physical; Geosciences, Multidisciplinary SC Physical Geography; Geology GA CH2TU UT WOS:000353878400002 ER PT S AU Friebele, EJ Baker, CC Askins, CG Fontana, JP Hunt, MP Peele, JR Marcheschi, BA Oh, E Kim, W Sanghera, J Zhang, J Pattnaik, RK Merkle, LD Dubinskii, M AF Friebele, E. Joseph Baker, Colin C. Askins, Charles G. Fontana, Jake P. Hunt, Michael P. Peele, John R. Marcheschi, Barbara A. Oh, Eunkeu Kim, Woohong Sanghera, Jasbinder Zhang, Jun Pattnaik, Radha K. Merkle, Larry D. Dubinskii, Mark BE Shaw, LB Ballato, J TI Erbium nanoparticle doped fibers for efficient, resonantly-pumped Er-doped fiber lasers SO FIBER LASERS XII: TECHNOLOGY, SYSTEMS, AND APPLICATIONS SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Fiber Lasers XII - Technology, Systems, and Applications CY FEB 09-12, 2015 CL San Francisco, CA SP SPIE, NKT Photon A S, PolarOnyx Inc DE Erbium doped fiber; nanoparticles; high energy lasers; fiber lasers ID SIZE; BOEHMITE; SHAPE AB Nanoparticle (NP) doping is a new technique for making erbium-doped fibers (EDFs); the Er ions are surrounded by a cage of aluminum and oxygen ions, substantially reducing Er3+ ion-ion energy exchange and its deleterious effects on laser performance. Er-Al-doped NPs have been synthesized and doped in-situ into the silica soot of the preform core. We report the first known measurements of NP-doped EDFs in a resonantly-core pumped master oscillator-power amplifier (MOPA) configuration; the optical-to-optical slope efficiency was 80.4%, which we believe is a record for this type of fiber. C1 [Friebele, E. Joseph; Baker, Colin C.; Askins, Charles G.; Fontana, Jake P.; Marcheschi, Barbara A.; Kim, Woohong; Sanghera, Jasbinder] Naval Res Lab, Washington, DC 20375 USA. [Hunt, Michael P.] Univ Res Fdn, Greenbelt, MD 20770 USA. [Peele, John R.; Oh, Eunkeu] Sotera Def Syst, Columbia, MD 21046 USA. [Zhang, Jun; Pattnaik, Radha K.; Merkle, Larry D.; Dubinskii, Mark] Army Res Lab, Ade Iphi, MD 20783 USA. RP Friebele, EJ (reprint author), Naval Res Lab, 4555 Overlook Ave SW, Washington, DC 20375 USA. EM joe.friebele@ndnavy.mil RI Baker, Colin/I-6657-2015 NR 11 TC 1 Z9 1 U1 0 U2 9 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-434-9 J9 PROC SPIE PY 2015 VL 9344 AR 934412 DI 10.1117/12.2079443 PG 8 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BC6EZ UT WOS:000353887400025 ER PT J AU Allison, PG Moser, RD Chandler, MQ Caminero-Rodriguez, JA Torres-Cancel, K Rivera, OG Goodwin, JR Gore, ER Weiss, CA AF Allison, P. G. Moser, R. D. Chandler, M. Q. Caminero-Rodriguez, J. A. Torres-Cancel, K. Rivera, O. G. Goodwin, J. R. Gore, E. R. Weiss, C. A., Jr. TI Mechanical, Thermal, and Microstructural Analysis of Polyvinyl Alcohol/Montmorillonite Nanocomposites SO JOURNAL OF NANOMATERIALS LA English DT Article ID MONTMORILLONITE NANOCOMPOSITES; POLY(VINYL ALCOHOL); SCALES; NACRE; FILMS; CLAY; DEFORMATION; TENSILE; SHEAR; BONE AB Structural biomaterials such as nacre, bone, and fish scales possess unique structures that have hierarchical spatial configurations, which provide excellent mechanical properties when compared to their individual constituents. These observations have been the motivation for designing and characterizing bioinspired materials with high strength, high stiffness, and corrosion-resistant properties while at the same time being environmentally friendly. It has been demonstrated that polymer-clay nanocomposites can simulate the behavior of nacreous biomaterials such as abalone shell. Mechanical, thermal, and microstructural analyses characterized solution-cast polyvinyl alcohol (PVA)/montmorillonite (MMT) nanocomposite properties over compositions ranging from the neat polymer to 25% volume fraction of MMT nanoclay. Uniaxial tensile experiments were performed at displacement rates of 1 mm/min and 50 mm/min. Strength values are similar to those shown by nacre and represent a homogeneous dispersion of the MMT in the polymer matrix. Strength-to-weight ratios are similar to many structural metals. C1 [Allison, P. G.; Rivera, O. G.] Univ Alabama, Dept Mech Engn, Tuscaloosa, AL 35487 USA. [Moser, R. D.; Chandler, M. Q.; Torres-Cancel, K.; Gore, E. R.; Weiss, C. A., Jr.] US Army Engn Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. [Caminero-Rodriguez, J. A.] Univ Puerto Rico Mayaguez, Dept Chem Engn, Mayaguez, PR 00680 USA. [Goodwin, J. R.] Univ Alabama, Cent Analyt Facil, Tuscaloosa, AL 35487 USA. RP Allison, PG (reprint author), Univ Alabama, Dept Mech Engn, Tuscaloosa, AL 35487 USA. EM pallison@eng.ua.edu FU Center-Directed Research Program, US Army Engineer Research and Development Center FX The authors would like to acknowledge funding provided for this work by the Center-Directed Research Program, US Army Engineer Research and Development Center. Permission to publish was granted by Director of Geotechnical and Structures Laboratory. NR 33 TC 1 Z9 1 U1 5 U2 30 PU HINDAWI PUBLISHING CORPORATION PI NEW YORK PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA SN 1687-4110 EI 1687-4129 J9 J NANOMATER JI J. Nanomater. PY 2015 AR 291248 DI 10.1155/2015/291248 PG 9 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA CH9PC UT WOS:000354367000001 ER PT S AU Shterengas, L Liang, R Hosoda, T Kipshidze, G Belenky, G Bowman, SS Tober, RL AF Shterengas, L. Liang, R. Hosoda, T. Kipshidze, G. Belenky, G. Bowman, S. S. Tober, R. L. BE Belyanin, AA Smowton, PM TI Type-I QW cascade diode lasers with 960 mW of CW power at 3 mu m. SO NOVEL IN-PLANE SEMICONDUCTOR LASERS XIV SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Novel In-Plane Semiconductor Lasers XIV CY FEB 09-12, 2015 CL San Francisco, CA SP SPIE DE diode lasers; mid-infrared; cascade pumping; type-I quantum well; antimonides; high power ID WAVE OUTPUT POWER AB Cascade pumping schemes that utilize single-QW gain stages enhanced both the power conversion efficiency and the output power level of GaSb-based diode lasers that emit near and above 3 mu m at room temperature. The cascade lasers discussed in this work had densely stacked type-I QWs gain stages characterized by high differential gain. The 3 mu m emitting devices demonstrated CW threshold current densities near 100 A/cm(2), a twofold improvement over the previous world record, that resulted in peak power conversion efficiencies increasing to 16% at 170C. Comparable narrow ridge two-stage devices generated more than 100 mW of CW power with similar to 10% power conversion efficiencies. Three-stage multimode cascade lasers emitted 960 mW of CW output power near 3 mu m and 120 mW CW near 3.3 mu m. C1 [Shterengas, L.; Liang, R.; Hosoda, T.; Kipshidze, G.; Belenky, G.] SUNY Stony Brook, Stony Brook, NY 11794 USA. [Bowman, S. S.; Tober, R. L.] Army Res Lab, Adelphi, MD 20783 USA. RP Shterengas, L (reprint author), SUNY Stony Brook, Stony Brook, NY 11794 USA. NR 14 TC 1 Z9 1 U1 2 U2 8 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-472-1 J9 PROC SPIE PY 2015 VL 9382 AR 93820X DI 10.1117/12.2076631 PG 9 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BC6FH UT WOS:000353892500019 ER PT S AU Merkle, LD Zhang, J Allen, G Dawson, JW Dubinskii, M AF Merkle, Larry D. Zhang, Jun Allen, Graham Dawson, Jay W. Dubinskii, Mark BE Jiang, S Digonnet, MJF TI Raman Gain of SiC as a Potential Medium for Raman Lasers SO OPTICAL COMPONENTS AND MATERIALS XII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Optical Components and Materials XII CY FEB 09-11, 2015 CL San Francisco, CA SP SPIE DE Raman gain; Raman laser; SiC ID POLYTYPES AB We have investigated stimulated Raman scattering in the 4H polytype of SiC, due to its excellent thermal conductivity which is of great importance for power scaling of Raman lasers. Spectroscopy verifies the sample's polytype and precludes any significant admixture of other polytypes. Tests indicate the moderate optical quality of this commercially available sample. Using pump-probe measurements around 1030 nm, we find the Raman gain coefficient of the major peak at 777 cm(-1) to be 0.46 cm/GW. Although this value is only modest, calculations and experience with other Raman materials indicate that Raman lasing of 4H SiC should be possible with reasonable intensities of 1064-nm pulsed pumping. C1 [Merkle, Larry D.; Zhang, Jun; Dubinskii, Mark] RDRL SEE L, Army Res Lab, Adelphi, MD 20783 USA. [Allen, Graham; Dawson, Jay W.] Lawrence Livermore Natl Lab, Livermore, CA 94550 USA. RP Merkle, LD (reprint author), RDRL SEE L, Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM larry.d.merkle.civ@mail.mil NR 8 TC 0 Z9 0 U1 1 U2 5 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-449-3 J9 PROC SPIE PY 2015 VL 9359 AR 935904 DI 10.1117/12.2077299 PG 6 WC Materials Science, Multidisciplinary; Optics SC Materials Science; Optics GA BC6OT UT WOS:000354268500003 ER PT S AU Cole, B Goldberg, L Hough, N Nettleton, J AF Cole, Brian Goldberg, Lew Hough, Nathaniel Nettleton, John BE Clarkson, WA Shori, RK TI Investigation of mechanically Q-switched lasers SO SOLID STATE LASERS XXIV: TECHNOLOGY AND DEVICES SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Solid State Lasers XXIV - Technology and Devices CY FEB 08-10, 2015 CL San Francisco, CA SP SPIE DE Solid state lasers; Er/Yb glass laser; Nd:YAG; mechanical Q-switch; MEMS Q-switch ID MICROMIRROR; MIRROR AB Using a resonant scanner mirror Q-switch to provide a time varying change in cavity alignment, 1535nm lasers based on Er/Yb-doped glass and 1064nm lasers based on Nd:YAG were evaluated. Using a side pumping architecture, the Er/Yb glass laser used a compact mechanical Q-switch with a mirror rotation rate of 330 Rad/s, enabling generation of >3 mJ pulses with a pulse width of 16ns. The laser output was a diffraction limited TEM00 mode. A mechanical Q-switch based on a MEMS tilting mirror was also used; its performance in a laser cavity was found to be similar to the resonant mirror. The technique of mechanical Q-switching was also extended to a side pumped Nd: YAG laser (mirror sweep rate of 1300 Rad/s), enabling generation of Q-switched pulses of >30mJ and 25ns duration. The far-field divergence showed this laser to be highly multi-moded within the pump plane, with a measured beam-product-parameter greater than 30 mm-mRad. C1 [Cole, Brian; Goldberg, Lew; Hough, Nathaniel; Nettleton, John] US Army, Night Vis & Elect Sensors Directorate, RDECOM CERDEC, Ft Belvoir, VA 22060 USA. RP Cole, B (reprint author), US Army, Night Vis & Elect Sensors Directorate, RDECOM CERDEC, Ft Belvoir, VA 22060 USA. EM info@nvl.army.mil NR 9 TC 1 Z9 1 U1 2 U2 4 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-432-5 J9 PROC SPIE PY 2015 VL 9342 AR 93421P DI 10.1117/12.2081256 PG 7 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BC6FA UT WOS:000353888400045 ER PT S AU Evans, JW Sanamyan, T Berry, PA AF Evans, Jonathan W. Sanamyan, Tigran Berry, Patrick A. BE Clarkson, WA Shori, RK TI A continuous-wave Fe:ZnSe laser pumped by an efficient Er:Y2O3 laser SO SOLID STATE LASERS XXIV: TECHNOLOGY AND DEVICES SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Solid State Lasers XXIV - Technology and Devices CY FEB 08-10, 2015 CL San Francisco, CA SP SPIE DE solid-state lasers; mid-IR lasers; transition-metal lasers ID FE/ZNSE LASER; ZNSE AB Fe:ZnSe lasers have been pumped by several types of diode-pumped solid state laser, including Cr:Er:YSGG (2800 nm),(1) Cr:CdSe (2970 nm),(2) and Er:YAG (2698 nm,(3) 2936 nm(4)). None of these sources has exceeded 1.5 W of true continuous-wave (CW) output power. In this work, we report demonstration of a CW Fe:ZnSe laser pumped by a 10 W Er:Y2O3 laser emitting at 2740 nm,(5) which had not been previously attempted. The Er:Y2O3 pump laser was characterized with respect to propagation losses, beam quality, mode size, and pointing stability. It was determined that the limit of output power from the Fe:ZnSe laser was limited by the output stability of the pump laser. The Fe:ZnSe laser operated with >22% slope efficiency and 800 mW output power was achieved at approximately 4050 nm. C1 [Evans, Jonathan W.; Berry, Patrick A.] Air Force Res Lab, Sensors Directorate, Wright Patterson AFB, OH 45433 USA. [Sanamyan, Tigran] Army Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. RP Evans, JW (reprint author), Air Force Res Lab, Sensors Directorate, Wright Patterson AFB, OH 45433 USA. EM jonathan.evans.6@us.af.mil NR 7 TC 0 Z9 0 U1 3 U2 16 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-432-5 J9 PROC SPIE PY 2015 VL 9342 AR UNSP 93420F DI 10.1117/12.2079757 PG 6 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BC6FA UT WOS:000353888400012 ER PT S AU Shen, TC Drost, RJ Rzasa, J Sadler, BM Davis, CC AF Shen, Thomas C. Drost, Robert J. Rzasa, John Sadler, Brian M. Davis, Christopher C. BE Hemmati, H Boroson, DM TI Panoramic Alignment System for Optical Wireless Communication Systems SO FREE-SPACE LASER COMMUNICATION AND ATMOSPHERIC PROPAGATION XXVII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Free-Space Laser Communication and Atmospheric Propagation XXVII CY FEB 08-09, 2015 CL San Francisco, CA SP SPIE DE light-emitting diodes; free space optical systems; pointing acquisition and tracking ID RF; LIGHT AB Free space optical communication may provide a viable adjunct to radio frequency (RF) technology for mobile communications, especially in "RF-denied" settings in which RF-based communication may be prohibited or impractical. These settings may include military tactical environments or settings which suffer from RF jamming or interference. Unlike many RF communication systems, point-to-point optical communications between mobile nodes typically require establishing and maintaining alignment, which requires each node to have awareness of the locations of neighboring nodes. We propose a method to create this situational awareness between nodes using purely optical means. This method uses a camera that is focused on a hyperboloidal mirror, thus providing a 360-degree view of the surrounding environment. The camera and mirror are used to detect light emitted from the beacon transmitters from neighboring nodes, with the location of the beacon image in the sensor plane of the camera yielding elevation and azimuth information of the beacon. The beacon transmitter itself is modulated, allowing it to be distinguished from the environment. In discussing our experimental realization of this system, we assess its performance. C1 [Shen, Thomas C.; Rzasa, John; Davis, Christopher C.] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. [Drost, Robert J.; Sadler, Brian M.] US Army Res Lab, Adelphi, MD USA. RP Shen, TC (reprint author), Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. EM tshen@umd.edu NR 22 TC 2 Z9 2 U1 2 U2 4 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-444-8 J9 PROC SPIE PY 2015 VL 9354 AR 93540M DI 10.1117/12.2080091 PG 6 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BC6AR UT WOS:000353710100018 ER PT J AU Kwon, P Lundin, J Li, WJ Ray, R Littell, C Gao, DL Thomas, DB Checkoway, H AF Kwon, Paul Lundin, Jessica Li, Wenjin Ray, Roberta Littell, Christopher Gao, Daoli Thomas, David B. Checkoway, Harvey TI Night Shift Work and Lung Cancer Risk Among Female Textile Workers in Shanghai, China SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article DE Chinese female; lung cancer; night shift; shift work; textile workers ID ESTROGEN-RECEPTOR-BETA; BREAST SELF-EXAMINATION; NEVER SMOKERS; COTTON DUST; RANDOMIZED-TRIAL; UNITED-STATES; WOMEN; ENDOTOXIN; MELATONIN; EXPOSURE AB In 2007, the International Agency for Research on Cancer classified shift work that involves circadian disruption as a probable human carcinogen. Suppression of the antineoplastic hormone, melatonin, is a presumed mechanism of action. We conducted a case-cohort study nested within a cohort of 267,400 female textile workers in Shanghai, China. Newly diagnosed lung cancer cases (n = 1451) identified during the study period (1989-2006) were compared with an age-stratified subcohort (n = 3040). Adjusting for age, smoking, parity, and endotoxin exposure, relative risks [hazard ratios (HRs)] were estimated by Cox regression modeling to assess associations with cumulative years and nights of rotating shift work. Results did not consistently reveal any increased risk of lung cancer among rotating shift work or statistically significant trends for both cumulative years (HR 0.82, 95% CI 0.66 to 1.02; P-trend = 0.294) and nights (HR 0.81, 95% CI 0.65 to 1.00; P-trend = 0.415). Further analyses imposing 10- and 20-year lag times for disease latency also revealed similar results. Contrary to the initial hypothesis, rotating nighttime shift work appears to be associated with a relatively reduced lung cancer risk although the magnitude of the effect was modest and not statistically significant. C1 [Kwon, Paul] Bassett Army Community Hosp, Dept Prevent Med, Ft Wainwright, AK USA. [Lundin, Jessica] Univ Washington, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USA. [Li, Wenjin; Ray, Roberta; Thomas, David B.] Fred Hutchinson Canc Res Ctr, Dept Epidemiol, Seattle, WA 98104 USA. [Littell, Christopher] Walter Reed Army Inst Res, Dept Epidemiol, Rockville, MD USA. [Gao, Daoli] Fudan Univ, Zhongshan Hosp, Dept Epidemiol, Shanghai 200433, Peoples R China. [Checkoway, Harvey] Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA. RP Kwon, P (reprint author), Bassett Army Community Hosp MCUC PM, Ft Wainwright, AK 99703 USA. EM drpaulkwon@gmail.com FU National Institutes of Health (NIH) [NIH R01CA80180] FX This work was supported by a National Institutes of Health (NIH) grant (NIH R01CA80180). NR 47 TC 3 Z9 3 U1 2 U2 9 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1545-9624 EI 1545-9632 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PY 2015 VL 12 IS 5 BP 334 EP 341 DI 10.1080/15459624.2014.993472 PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA CG8UP UT WOS:000353590000010 PM 25616851 ER PT B AU Boutte, A Kobeissy, F Wang, KKW Zhang, ZQ Tortella, F Dave, JR Schmid, K AF Boutte, Angela Kobeissy, Firas Wang, Kevin K. W. Zhang, Zhiqun Tortella, Frank Dave, Jitendra R. Schmid, Kara BE Wang, KKW Zhang, Z Kobeissy, FH TI Protein Biomarkers in Traumatic Brain Injury: An Omics Approach SO BIOMARKERS OF BRAIN INJURY AND NEUROLOGICAL DISORDERS LA English DT Article; Book Chapter ID CONTROLLED CORTICAL IMPACT; ALPHA-II-SPECTRIN; TANDEM MASS-SPECTROMETRY; FIBRILLARY ACIDIC PROTEIN; DIFFERENCE GEL-ELECTROPHORESIS; ELEVATED INTRACRANIAL-PRESSURE; CENTRAL-NERVOUS-SYSTEM; CEREBROSPINAL-FLUID; PROTEOMIC ANALYSIS; LABEL-FREE C1 [Boutte, Angela; Tortella, Frank; Dave, Jitendra R.; Schmid, Kara] Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Branch Brain Trauma Neuroprotect & Neurorestorat, Silver Spring, MD 20910 USA. [Kobeissy, Firas; Wang, Kevin K. W.; Zhang, Zhiqun] Univ Florida, McKnight Brain Inst, Ctr Neuroprote & Biomarkers Res, Dept Psychiat, Gainesville, FL 32611 USA. [Kobeissy, Firas; Wang, Kevin K. W.; Zhang, Zhiqun] Univ Florida, McKnight Brain Inst, Ctr Neuroprote & Biomarkers Res, Dept Neurosci, Gainesville, FL 32611 USA. RP Boutte, A (reprint author), Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Branch Brain Trauma Neuroprotect & Neurorestorat, Silver Spring, MD 20910 USA. EM angela.m.boutte.civ@mail.mil RI kobeissy, firas/E-7042-2017 OI kobeissy, firas/0000-0002-5008-6944 NR 159 TC 0 Z9 0 U1 0 U2 3 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-3983-6; 978-1-4822-3982-9 PY 2015 BP 42 EP 75 PG 34 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA BC5QT UT WOS:000353498500004 ER PT B AU Johnson, EA Yassin, W Guignet, M AF Johnson, Erik A. Yassin, Walid Guignet, Michelle BE Wang, KKW Zhang, Z Kobeissy, FH TI Inflammatory Biomarkers of Brain Injury and Disease SO Biomarkers of Brain Injury and Neurological Disorders LA English DT Article; Book Chapter ID TUMOR-NECROSIS-FACTOR; INTERLEUKIN-1 RECEPTOR ANTAGONIST; CENTRAL-NERVOUS-SYSTEM; FOCAL CEREBRAL-ISCHEMIA; ACUTE-PHASE RESPONSE; GLUTAMATE-INDUCED EXCITOTOXICITY; MICROVASCULAR ENDOTHELIAL-CELLS; INDUCED STATUS EPILEPTICUS; MESSENGER-RNA EXPRESSION; GROWTH-FACTOR PRODUCTION C1 [Johnson, Erik A.; Guignet, Michelle] US Army, Med Res Inst Chem Def, Div Res, Pharmacol Branch, Aberdeen Proving Ground, MD 21010 USA. [Yassin, Walid] Kyoto Univ, Grad Sch Med, Dept Neuropsychiat, Kyoto 6068501, Japan. RP Johnson, EA (reprint author), US Army, Med Res Inst Chem Def, Div Res, Pharmacol Branch, 3100 Ricketts Point, Aberdeen Proving Ground, MD 21010 USA. EM erik.a.johnson1.civ@mail.mil NR 254 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4822-3983-6; 978-1-4822-3982-9 PY 2015 BP 304 EP 339 PG 36 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA BC5QT UT WOS:000353498500012 ER PT S AU Dang, G Taysing-Lara, M Zhou, WM Sun, TB Yang, WJ Chang-Hasnain, CJ AF Dang, Gerard Taysing-Lara, Monica Zhou, Weimin Sun, Tianbo Yang, Weijian Chang-Hasnain, Connie J. BE ChangHasnain, CJ Fattal, D Koyama, F Zhou, W TI Design and fabrication of 3D high-contrast metastructure THz cage waveguides SO HIGH CONTRAST METASTRUCTURES IV SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on High Contrast Metastructures IV CY FEB 11-12, 2015 CL San Francisco, CA SP SPIE DE hollow-core waveguide; high-contrast gratings; silicon; metastructure; THz AB We have designed new THz metastructure waveguides on Si wafers, aimed for low propagation loss and integration with Si-based integrated circuits. The waveguide has a round cross-sectional hollow-core, surrounded by high reflection-cladding-walls formed by high-contrast metastructure gratings. We developed a new fabrication technique to fabricate such a 3D metastructure cage waveguide structure. The waveguide is built using the entire wafer thickness which involves deep Si etching of periodically spaced holes and using isotropic undercut etching to create a connecting a line of etched spheres in the middle of the wafer to form the waveguide's hollow core, then deep etch the high-contrast grating through the entire wafer thickness to form the cladding for the waveguide. We have successfully modeled and fabricated such a waveguide structure. The next step is to experimentally test and characterize the waveguide in the THz spectrum range. C1 [Dang, Gerard; Taysing-Lara, Monica; Zhou, Weimin] US Army, Res Lab, Adelphi, MD 20783 USA. [Sun, Tianbo; Yang, Weijian; Chang-Hasnain, Connie J.] Univ Calif Berkeley, Berkeley, CA 94704 USA. RP Dang, G (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA. NR 5 TC 0 Z9 0 U1 0 U2 3 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-462-2 J9 PROC SPIE PY 2015 VL 9372 AR 93720J DI 10.1117/12.2079720 PG 8 WC Optics SC Optics GA BC5JG UT WOS:000353321800012 ER PT J AU Gunasekara, I Mukerjee, S Plichta, EJ Hendrickson, MA Abraham, KM AF Gunasekara, Iromie Mukerjee, Sanjeev Plichta, Edward J. Hendrickson, Mary A. Abraham, K. M. TI A Study of the Influence of Lithium Salt Anions on Oxygen Reduction Reactions in Li-Air Batteries SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID IONIC LIQUID; ELECTROLYTE; SOLVENTS; ELECTROCHEMISTRY; MICROELECTRODE; PERMITTIVITY; TEMPERATURES; PERFORMANCE; CHEMISTRY; MOLECULE AB The influence of lithium salts on O-2 reduction reactions (ORR) in I. 2-dimethoxyethane (DME) and tetraethylene glycol dimethyl ether (TEGDME) has been investigated. Microelectrode studies in a series of tetrabutylammonium salt (TBA salt)/DME-based electrolytes showed that O-2 solubility and diffusion coefficient are not significantly affected by the electrolyte anion. The ORR voltammograms on microelectrodes in these electrolytes exhibited steady-state limiting current behavior. In contrast, peak-shaped voltammograms were observed in Li+-conducting electrolytes suggesting a reduction of the effective electrode area by passivating ORR products as well as migration-diffusion control of the reactants at the microelectrode. FT-IR spectra have revealed that Li+ ions are solvated to form solvent separated ion pairs of the type Li+(DME)(n)PF6- and Li-(TEGDME)PF6- in LiPF6-based electrolytes. On the other hand, the contact ion pairs (DME),Li+(CF3S03) and(TEGDNIE)Li+(CF3SO3-) appear to form in LiSO3CF3-containing electrolytes. In the LiSO3CF3 based electrolytes the initial ORR product, superoxide (O-2). is stabilized in solution by forming I(DME)(m-1) (O-2(-))[Li+(CF3SO3-) and RTEGDME)(O-2(-))1Li(+)(CF3SO3-) complexes. These soluble superoxide complexes are able to diffuse away from the electrode surface reaction sites to the bulk electrolyte in the electrode pores where they decompose to form Li2O2. This explains the higher capacity obtained in Li/02 cells utilizing LiCF3SO3-/TEGDME electrolytes. (C) 2015 The Electrochemical Society. All rights reserved. C1 [Gunasekara, Iromie; Mukerjee, Sanjeev; Abraham, K. M.] Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA. [Plichta, Edward J.; Hendrickson, Mary A.] US Army, Power Div, RDECOM CERDEC CP&I, RDER CCP, Aberdeen Proving Ground, MD 21005 USA. RP Gunasekara, I (reprint author), Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA. EM kmabraham@comcast.net FU U.S. Army CERDEC [GTS-S-13-025] FX We sincerely thank U.S. Army CERDEC for the financial support provided through subcontract No. GTS-S-13-025 for this work. NR 35 TC 21 Z9 21 U1 3 U2 60 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 SOUTH MAIN STREET, PENNINGTON, NJ 08534 USA SN 0013-4651 EI 1945-7111 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PY 2015 VL 162 IS 6 BP A1055 EP A1066 DI 10.1149/2.0841506jes PG 12 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA CG1BZ UT WOS:000353009300037 ER PT S AU Chee, J Hwu, J Kim, TS Kubby, J Velicu, S Gupta, N AF Chee, J. Hwu, J. Kim, T. S. Kubby, J. Velicu, S. Gupta, N. BE Piyawattanametha, W Park, YH TI Large Size MOEMS Fabry-Perot Interferometer Filter for Focal Plane Array Hyperspectral Imaging SO MOEMS AND MINIATURIZED SYSTEMS XIV SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on MOEMS and Miniaturized Systems XIV CY FEB 09-12, 2015 CL San Francisco, CA SP SPIE, Samsung Adv Inst Technol DE Fabry-Perot interferometer filter (FPF); micro-opto-electro-mechanical systems (MOEMS); focal place array (FPA); long wavelength infrared (LWIR) AB Focal plane array (FPA) technology is mature and is widely used for imaging applications. However, FPAs have broadband responses which limit their ability to provide high performance in hyperspectral applications such as detection of buried explosives, and identifying the presence of explosive chemicals and their concentrations. EPIR is currently developing Micro-Opto-Electro-Mechanical System (MOEMS) Fabry-Perot interferometer filter (FPF) devices for FPAs. In this paper, we present our approach to MOEMS FPF design and fabrication that will meet the size requirements for large format FPA hyperspectral imaging. We also report the performance of our FPF resonance cavity, capable of up to 3 mu m change gap in tens of nanometer increments. C1 [Chee, J.; Velicu, S.] EPIR Technol, Bolingbrook, IL 60440 USA. [Hwu, J.; Kim, T. S.; Kubby, J.] Univ Calif Santa Cruz, Dept Elect Engn, Santa Cruz, CA 95064 USA. [Gupta, N.] US Army Res Lab, Adelphi, MD 20783 USA. RP Chee, J (reprint author), EPIR Technol, 590 Terr Dr, Bolingbrook, IL 60440 USA. EM jchee@epir.com NR 7 TC 0 Z9 0 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-465-3 J9 PROC SPIE PY 2015 VL 9375 AR 93750K DI 10.1117/12.2076615 PG 7 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Optics SC Engineering; Science & Technology - Other Topics; Optics GA BC5AI UT WOS:000353125900016 ER PT S AU Milanovic, V Kasturi, A Atwood, B Su, Y Limkrailassiri, K Nettleton, JE Goldberg, L Cole, BJ Hough, N AF Milanovic, Veljko Kasturi, Abhishek Atwood, Bryan Su, Yu Limkrailassiri, Kevin Nettleton, John E. Goldberg, Lew Cole, Brian J. Hough, Nathaniel BE Piyawattanametha, W Park, YH TI Compact MEMS Mirror Based Q-Switch Module for Pulse-on-demand Laser Range Finders SO MOEMS AND MINIATURIZED SYSTEMS XIV SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on MOEMS and Miniaturized Systems XIV CY FEB 09-12, 2015 CL San Francisco, CA SP SPIE, Samsung Adv Inst Technol DE MEMS; MEMS Mirror; Q-Switch; HR mirror; Er:Glass; Er/Yb; laser range finder ID MICRO-MIRROR; SYSTEM AB A highly compact and low power consuming Q-switch module was developed based on a fast single-axis MEMS mirror, for use in eye-safe battery-powered laser range finders. The module's 1.6mm x 1 6mm mirror has >99% reflectance at 1535nm wavelength and can achieve mechanical angle slew rates of over 500 rad/sec when switching the Er/Yb:Glass lasing cavity from pumping to lasing state. The design targeted higher efficiency, smaller size, and lower cost than the traditional Electro-Optical Q-Switch. Because pulse-on-demand capability is required, resonant mirrors cannot be used to achieve the needed performance. Instead, a fast point-to-point analog single-axis tilt actuator was designed with a custom-coated high reflectance (HR) mirror to withstand the high intra-cavity laser fluence levels. The mirror is bonded on top of the MEMS actuator in final assembly. A compact MEMS controller was further implemented with the capability of autonomous on-demand operation based on user-provided digital trigger. The controller is designed to receive an external 3V power supply and a digital trigger and it consumes similar to 90mW during the short switching cycle and similar to 10mW in standby mode. Module prototypes were tested in a laser cavity and demonstrated high quality laser pulses with duration of 20ns and energy of over 3mJ. C1 [Milanovic, Veljko; Kasturi, Abhishek; Atwood, Bryan; Su, Yu; Limkrailassiri, Kevin] Mirrorcle Technol Inc, Richmond, CA 94804 USA. [Nettleton, John E.; Goldberg, Lew; Cole, Brian J.] US ARMY Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA. [Hough, Nathaniel] Fibertek Inc, Ft Belvoir, VA USA. RP Milanovic, V (reprint author), Mirrorcle Technol Inc, Richmond, CA 94804 USA. NR 16 TC 0 Z9 0 U1 1 U2 3 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-1-62841-465-3 J9 PROC SPIE PY 2015 VL 9375 AR 93750H DI 10.1117/12.2082212 PG 7 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Optics SC Engineering; Science & Technology - Other Topics; Optics GA BC5AI UT WOS:000353125900013 ER PT J AU Miller, AE Brosi, BJ Magnacca, K Daily, GC Pejchar, L AF Miller, Adam E. Brosi, Berry J. Magnacca, Karl Daily, Gretchen C. Pejchar, Liba TI Pollen Carried By Native and Nonnative Bees in the Large-scale Reforestation of Pastureland in Hawai'i: Implications for Pollination SO PACIFIC SCIENCE LA English DT Article ID BIODIVERSITY HOTSPOTS; INTRODUCED HONEYBEES; FORAGING BEHAVIOR; APIS-MELLIFERA; FRUIT-SET; CONSERVATION; ISLANDS; MUTUALISMS; FLOWERS; COMMUNITIES AB Due to habitat loss, disease, and introduction of nonnative species, many native species in Hawai'i have gone extinct or are at risk of extinction. As a result of interspecific interactions such as pollination, the decline, loss, or introduction of species can have cascading effects on island ecosystems. We studied Hylaeus spp., Hawai'i's yellow-faced bees, the only native bees in Hawai'i. This group of potentially important pollinators has been largely overlooked until recently, and its conservation status and ecological role are virtually unknown. We investigated how native (Hylaeus spp.) and nonnative (Apis mellifera) bees interact with flowering plants in a large-scale pasture-to-forest restoration system. We used pan traps and nets to collect bees in mature forest, remnant corridors, planted Acacia koa tracts, and open pastureland. We removed pollen from each specimen and identified it using pollen samples collected on-site. We found that Hylaeus spp. were more likely to carry less pollen and more likely to exhibit higher pollinator fidelity compared with A. mellifera. By contrast, A. mellifera was more likely to carry mixed pollen and forage on invasive plant species. This is the first investigation in Hawai` i to compare patterns of pollen carriage between native and nonnative bees and the first study to document pollen carried by Hylaeus spp. in the context of forest restoration. C1 [Miller, Adam E.; Pejchar, Liba] Colorado State Univ, Dept Fish Wildlife & Conservat Biol, Ft Collins, CO 80523 USA. [Brosi, Berry J.] Emory Univ, Dept Environm Sci, Atlanta, GA 30322 USA. [Magnacca, Karl] Oahu Army Nat Resources Program, Pacific Cooperat Studies Unit, Schofield Barracks, HI 96857 USA. [Daily, Gretchen C.] Stanford Univ, Dept Biol, Stanford, CA 94305 USA. [Daily, Gretchen C.] Stanford Univ, Woods Inst, Stanford, CA 94305 USA. RP Pejchar, L (reprint author), Colorado State Univ, Dept Fish Wildlife & Conservat Biol, Ft Collins, CO 80523 USA. EM Liba.pejchar@colostate.edu FU Moore Family Foundation; Winslow Foundation; Peter and Helen Bing FX Funding provided by the Moore Family Foundation, the Winslow Foundation, and Peter and Helen Bing. NR 67 TC 1 Z9 1 U1 10 U2 41 PU UNIV HAWAII PRESS PI HONOLULU PA 2840 KOLOWALU ST, HONOLULU, HI 96822 USA SN 0030-8870 EI 1534-6188 J9 PAC SCI JI Pac. Sci. PD JAN PY 2015 VL 69 IS 1 BP 67 EP 79 DI 10.2984/69.1.5 PG 13 WC Marine & Freshwater Biology; Zoology SC Marine & Freshwater Biology; Zoology GA CG3HR UT WOS:000353171100005 ER PT J AU Brasfield, SM Hewitt, LM Chow, L Batchelor, S Rees, H Xing, ZS Munkittrick, KR AF Brasfield, Sandra M. Hewitt, L. Mark Chow, Lien Batchelor, Suzanne Rees, Herb Xing, Zisheng Munkittrick, Kelly R. TI Assessing the contribution of multiple stressors affecting small-bodied fish populations through a gradient of agricultural inputs in northwestern New Brunswick, Canada SO WATER QUALITY RESEARCH JOURNAL OF CANADA LA English DT Article DE pesticides; precipitation; sculpin; small-bodied fish; temperature ID SCULPIN COTTUS-COGNATUS; SLIMY SCULPIN; POTATO PRODUCTION; SOIL-EROSION; RUNOFF; WATER; SIZE; RECRUITMENT; PESTICIDES; POLLUTION AB Non-point source discharges, such as agricultural runoff, are often complex mixtures of chemical and non-chemical stressors. The complexity of runoff is compounded by its sporadic releases and few studies have attempted to assess the impacts of runoff on aquatic biota. In this study, an effects based approach was used to examine survival and reproduction of slimy sculpin (Cottus cognatus) in the intensive potato-farming areas of northwestern New Brunswick, Canada. Using non-lethal methods, fish were collected during the ice-free months through a gradient of agricultural intensity. These data were correlated with waterborne levels of pesticides, water temperatures and precipitation data. Results indicate that both adult and young-of-the-year (YOY) fish are longer and heavier in the downstream sites draining areas of higher agricultural intensity. Precipitation has a significant negative relationship with %YOY in the agricultural areas but not in the upstream forested area, indicating that contaminants are present in runoff caused by intensive rainfall events. Our results indicate that YOY sculpin may be at higher risk in the agricultural areas in years of heavier summer rains where peaks in pesticide levels occur. This study expands the existing knowledge base and development of non-lethal methods to define cause-effect relationships. C1 [Brasfield, Sandra M.] US Army, Engn Res & Dev Ctr, Waterways Expt Stn, Environm Risk Assessment Branch,EP R CEERD, Vicksburg, MS 39180 USA. [Brasfield, Sandra M.; Munkittrick, Kelly R.] Univ New Brunswick, Canadian Rivers Inst, Dept Biol, St John, NB E2L 4L5, Canada. [Hewitt, L. Mark; Batchelor, Suzanne] Environm Canada, Aquat Ecosyst Protect Res Branch, Burlington, ON L7R 4A6, Canada. [Chow, Lien; Rees, Herb] Agr & Agri Food Canada, Potato Res Ctr, Fredericton, NB E3B 4Z7, Canada. [Xing, Zisheng] Univ New Brunswick, Fac Forestry & Environm Management, Fredericton, NB E3B 5A3, Canada. RP Brasfield, SM (reprint author), US Army, Engn Res & Dev Ctr, Waterways Expt Stn, Environm Risk Assessment Branch,EP R CEERD, 3909 Halls Ferry Rd,Bldg 3270, Vicksburg, MS 39180 USA. EM sandra.m.brasfield@usace.army.mil FU Canadian Water Network; New Brunswick Innovation Fund; Environment Canada's Pesticide Science Fund; Natural Sciences and Engineering Research Council (NSERC); NSERC Discovery Grant; Networks of Centres of Excellence; Canada Research Chairs Program FX The authors received funding from the Canadian Water Network, the New Brunswick Innovation Fund, Environment Canada's Pesticide Science Fund and Natural Sciences and Engineering Research Council (NSERC). The invaluable help of countless field assistants, graduate students, and visiting scholars is greatly appreciated. Kelly Munkittrick receives support from a NSERC Discovery Grant, the Canadian Water Network, Networks of Centres of Excellence and from the Canada Research Chairs Program. NR 38 TC 0 Z9 0 U1 5 U2 15 PU IWA PUBLISHING PI LONDON PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND SN 1201-3080 J9 WATER QUAL RES J CAN JI Water Qual. Res. J. Canada PY 2015 VL 50 IS 2 BP 182 EP 197 DI 10.2166/wqrjc.2014.126 PG 16 WC Water Resources SC Water Resources GA CG3ZW UT WOS:000353220300007 ER PT J AU Alford, KL AF Alford, Kenneth L. TI Nels Anderson's World War I Diary SO BYU STUDIES QUARTERLY LA English DT Book Review C1 [Alford, Kenneth L.] Brigham Young Univ, Church Hist & Doctrine, Provo, UT 84602 USA. [Alford, Kenneth L.] US Army, Wright Patterson AFB, OH USA. [Alford, Kenneth L.] US Mil Acad, West Point, NY USA. [Alford, Kenneth L.] Natl Def Univ, Washington, DC 20319 USA. RP Alford, KL (reprint author), Brigham Young Univ, Church Hist & Doctrine, Provo, UT 84602 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU BRIGHAM YOUNG UNIV PI PROVO PA 290 LIFE SCIENCE MUSEUM, PROVO, UT 84602 USA SN 0007-0106 J9 BYU STUD Q JI BYU Stud. Q. PY 2015 VL 54 IS 1 BP 197 EP 200 PG 4 WC Humanities, Multidisciplinary SC Arts & Humanities - Other Topics GA CF8QB UT WOS:000352825900016 ER PT J AU Schafer, JL Breslow, BP Hohmann, MG Hoffmann, WA AF Schafer, Jennifer L. Breslow, Bradley P. Hohmann, Matthew G. Hoffmann, William A. TI RELATIVE BARK THICKNESS IS CORRELATED WITH TREE SPECIES DISTRIBUTIONS ALONG A FIRE FREQUENCY GRADIENT SO FIRE ECOLOGY LA English DT Article DE bark accumulation; inner bark proportion; longleaf pine savanna; Pinus; Quercus; stream-head pocosin ID TROPICAL SAVANNA; SURFACE FIRES; FOREST TREES; RESISTANCE; STRATEGIES; MORTALITY; DYNAMICS; HABITAT; TRAITS; REGIME AB The probability of stem survival after fire is strongly influenced by energy allocation to bark because bark thickness affects heat transfer during fire. Greater relative investment in inner bark versus outer bark should also enhance survival because of greater moisture content of inner bark. We measured stem diameter, bark thickness, and habitat preference of five species typical of long-leaf pine savannas, and six species characteristic of adjacent wetlands (pocosins), and calculated relative bark thickness, the inner bark proportion, radial growth, and bark accumulation of each species. We hypothesized that savanna species have thicker bark and greater relative investment in inner bark than pocosin species, because fires occur more frequently in savannas than pocosins. As hypothesized, savanna species have relatively thicker bark than pocosin species. Relative bark thickness and the rate of bark accumulation were correlated with the mean location of a species along the pocosin-to-savanna gradient. However, the inner bark proportion did not differ between savanna and pocosin species. Our results indicate that relative bark thickness is likely the primary bark trait affecting fire-induced topkill and influencing the distribution of species along the pocosin-to-savanna gradient. C1 [Schafer, Jennifer L.; Breslow, Bradley P.; Hoffmann, William A.] N Carolina State Univ, Dept Plant & Microbial Biol, Raleigh, NC 27695 USA. [Hohmann, Matthew G.] US Army, Corps Engineers, Engineer Res & Dev Ctr, Champaign, IL 61826 USA. RP Schafer, JL (reprint author), William Jewell Coll, Dept Biol, 500 Coll Hill, Liberty, MO 64068 USA. EM schaferj@william.jewell.edu FU US Army Engineer Research and Development Center [W9132T-11-2-0007]; North Carolina State University [W9132T-11-2-0007] FX The authors thank A. Bova for helpful discussions, S. Smith for statistical advice, and J. Gray and S. Pulsipher for logistical support. This manuscript was improved by comments from two anonymous reviewers and an associate editor. This research was supported by a cooperative agreement between the US Army Engineer Research and Development Center and North Carolina State University (W9132T-11-2-0007 to W. Hoffmann). NR 47 TC 3 Z9 3 U1 12 U2 37 PU ASSOC FIRE ECOLOGY PI EUGENE PA PO BOX 50412, EUGENE, OR 97405 USA SN 1933-9747 J9 FIRE ECOL JI Fire Ecol. PY 2015 VL 11 IS 1 BP 74 EP 87 DI 10.4996/fireecology.1101074 PG 14 WC Ecology; Forestry SC Environmental Sciences & Ecology; Forestry GA CF6GJ UT WOS:000352654800006 ER PT J AU Bufler, TD Narayanan, RM Dogaru, T AF Bufler, Travis D. Narayanan, Ram M. Dogaru, Traian TI Radar Signatures of Furniture Elements SO IEEE TRANSACTIONS ON AEROSPACE AND ELECTRONIC SYSTEMS LA English DT Article ID DIELECTRIC-PROPERTIES; GHZ; PERMITTIVITY; PROPAGATION; ANTENNAS AB Through-the-wall radar (TTWR) systems designed for detecting, locating, and tracking humans are plagued by harsh clutter scenarios caused by the variety and abundance of furniture elements within the antenna's field of view. This paper investigates the signatures of indoor clutter using radar cross section (RCS) and linear depolarization ratios to implement clutter suppression algorithms. The paper focuses on the analysis of common individual and composite pieces of indoor clutter for TTWR. The characterization of the wideband spectral properties of indoor clutter elements is accomplished using finite-difference time-domain (FDTD) techniques. Using FDTD, the spectral characteristics of clutter elements are obtained over a wide range of frequencies, different polarizations, and aspect angles. We compare and contrast the RCS responses between the different objects for analysis and use in TTWR. RCS results obtained from the simulations are compared to experimental data using a network analyzer and reasonable agreement is obtained. Clutter signatures are also compared to those of humans in order to design appropriate waveforms for maximizing the signal-to-clutter ratio in TTWR systems. C1 [Bufler, Travis D.; Narayanan, Ram M.] Penn State Univ, Elect Engn, University Pk, PA 16802 USA. [Dogaru, Traian] US Army Res Lab, Adelphi, MD 20783 USA. RP Bufler, TD (reprint author), Penn State Univ, Elect Engn, 202 EE East Bldg, University Pk, PA 16802 USA. EM ram@engr.psu.edu NR 26 TC 4 Z9 5 U1 1 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9251 EI 1557-9603 J9 IEEE T AERO ELEC SYS JI IEEE Trans. Aerosp. Electron. Syst. PD JAN PY 2015 VL 51 IS 1 BP 521 EP 535 DI 10.1109/TAES.2014.140301 PG 15 WC Engineering, Aerospace; Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA CF6XT UT WOS:000352700900041 ER PT J AU Zhang, SS AF Zhang, Sheng S. TI The redox mechanism of FeS2 in non-aqueous electrolytes for lithium and sodium batteries SO JOURNAL OF MATERIALS CHEMISTRY A LA English DT Review ID ABSORPTION FINE-STRUCTURE; POLYMER ELECTROLYTE; CRYSTAL-STRUCTURE; ELECTROCHEMICAL SYSTEM; POSITIVE ELECTRODES; PHASE-RELATIONSHIPS; PYRITE ELECTRODE; SOLID-STATE; TEMPERATURE; CATHODES AB Primary Li/FeS2 batteries have been commercialized and rechargeable Li-alloy/FeS2 batteries have been successfully operated at 375-500 degrees C by employing LiCl-based molten electrolytes. However, non-aqueous electrolyte rechargeable Li/FeS2 batteries have not yet been fulfilled due to poor reversibility and rapid capacity fading. The redox mechanism of FeS2 in non-aqueous electrolytes at ambient temperature is poorly understood and is still debated. In this mini-review, we analyse the experimental observations reported previously and propose a suitable mechanism that can explain all of the phenomena observed from the non-aqueous electrolyte Li/FeS2 and Na/FeS2 batteries. C1 US Army Res Lab, Electrochem Branch, RDRL SED C, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), US Army Res Lab, Electrochem Branch, RDRL SED C, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. EM shengshui.zhang.civ@mail.mil RI Zhang, Sheng/A-4456-2012 OI Zhang, Sheng/0000-0003-4435-4110 NR 29 TC 32 Z9 32 U1 25 U2 135 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2050-7488 EI 2050-7496 J9 J MATER CHEM A JI J. Mater. Chem. A PY 2015 VL 3 IS 15 BP 7689 EP 7694 DI 10.1039/c5ta00623f PG 6 WC Chemistry, Physical; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Energy & Fuels; Materials Science GA CF3IF UT WOS:000352441100001 ER PT J AU Scime, EE Keiter, PA Balkey, MM Kline, JL Sun, X Keesee, AM Hardin, RA Biloiu, IA Houshmandyar, S Thakur, SC Carr, J Galante, M McCarren, D Sears, S AF Scime, E. E. Keiter, P. A. Balkey, M. M. Kline, J. L. Sun, X. Keesee, A. M. Hardin, R. A. Biloiu, I. A. Houshmandyar, S. Thakur, S. Chakraborty Carr, J., Jr. Galante, M. McCarren, D. Sears, S. TI The hot hELicon eXperiment (HELIX) and the large experiment on instabilities and anisotropy (LEIA) SO JOURNAL OF PLASMA PHYSICS LA English DT Article ID ION TEMPERATURE ANISOTROPY; PLASMA; MAGNETOSHEATH; FREQUENCY; ELECTRON; DEVICE AB The West Virginia University Hot hELIcon eXperiment (HELIX) provides variable density and ion temperature plasmas, with controllable levels of thermal anisotropy, for space relevant laboratory experiments in the Large Experiment on Instabilities and Anisotropy (LEIA) as well as fundamental studies of helicon source physics in HELIX. Through auxiliary ion heating, the ion temperature anisotropy (T-perpendicular to/T-parallel to) is variable from 1 to 20 for parallel plasma beta (beta = 8 pi nkT(i parallel to)/B-2) values that span the range of 0.0001 to 0.01 in LEIA. The ion velocity distribution function is measured throughout the discharge volume in steady-state and pulsed plasmas with laser induced fluorescence (LIF). The wavelengths of very short wavelength electrostatic fluctuations are measured with a coherent microwave scattering system. Operating at low neutral pressures triggers spontaneous formation of a current-free electric double layer. Ion acceleration through the double layer is detected through LIF. LIF-based velocity space tomography of the accelerated beam provides a two-dimensional mapping of the bulk and beam ion distribution functions. The driving frequency for the m = 1 helical antenna is continuously variable from 8.5 to 16 MHz and frequency dependent variations of the RF coupling to the plasma allow the spontaneously appearing double layers to be turned on and off without modifying the plasma collisionality or magnetic field geometry. Single and multi-species plasmas are created with argon, helium, nitrogen, krypton, and xenon. The noble gas plasmas have steep neutral density gradients, with ionization levels reaching 100% in the core of the plasma source. The large plasma density in the source enables the study of Aflven waves in the HELIX device. C1 [Scime, E. E.; Balkey, M. M.; Keesee, A. M.; McCarren, D.; Sears, S.] Univ Virginia, Dept Phys & Astron, Morgantown, WV 26506 USA. [Keiter, P. A.] Univ Michigan, Dept Atmospher & Space Sci, Ann Arbor, MI 48109 USA. [Kline, J. L.] Los Alamos Natl Lab, Los Alamos, NM 87545 USA. [Sun, X.] Univ Sci & Technol China, Dept Modern Phys, Hefei 230026, Anhui, Peoples R China. [Hardin, R. A.] Wacker Polysilicon North Amer LLC, Charleston, TN 37310 USA. [Biloiu, I. A.] US Army Res Lab, Adelphi, MD 20783 USA. [Houshmandyar, S.] Gonzaga Univ, Dept Phys, Spokane, WA 99258 USA. [Thakur, S. Chakraborty] Univ Calif San Diego, Energy Res Ctr, San Diego, CA 92093 USA. [Carr, J., Jr.] Texas Lutheran Univ, Dept Phys, Seguin, TX 78155 USA. [Galante, M.] Univ Wisconsin, Dept Phys, Madison, WI 53706 USA. RP Scime, EE (reprint author), Univ Virginia, Dept Phys & Astron, Morgantown, WV 26506 USA. EM escime@wvu.edu OI Keesee, Amy/0000-0002-9719-3229; Kline, John/0000-0002-2271-9919 FU NSF [PHY-0611571] FX This work was supported by NSF award PHY-0611571. The authors thank one referee for suggesting the additional comparison with the theory of Reference 51 that is now shown in Fig. 15. NR 45 TC 4 Z9 4 U1 0 U2 11 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0022-3778 EI 1469-7807 J9 J PLASMA PHYS JI J. Plasma Phys. PD JAN PY 2015 VL 81 AR 345810103 DI 10.1017/S0022377814000890 PN 1 PG 22 WC Physics, Fluids & Plasmas SC Physics GA CE9WF UT WOS:000352193400020 ER PT J AU Taylor, TZ Psotka, J Legree, P AF Taylor, Teresa Z. Psotka, Joseph Legree, Peter TI Relationships among applications of tacit knowledge and transformational/transactional leader styles An exploratory comparison of the MLQ and TKML SO LEADERSHIP & ORGANIZATION DEVELOPMENT JOURNAL LA English DT Article DE Tacit knowledge; Transactional leadership; Practical intelligence; Transformational leadership; Leader levels; Problem solving ID SITUATIONAL JUDGMENT TESTS; PERFORMANCE; VALIDITY; AGREEMENT; SKILLS AB Purpose - The purpose of this paper is to examine intercorrelational relations among the self-report behavioral construct Multifactor Leadership Questionnaire (MLQ) 5X transformational and transactional subscales and the Tacit Knowledge for Military Leaders Inventory (TKML) leader-level specific situational judgment test scenarios. Design/methodology/approach - In total, two leadership measures, the behavioral construct MLQ and the cognitive construct TKML assess different aspects of how a leader functions and were administered to 125 active US Army officers representing three leader levels: platoon, company, and battalion. The authors examine the intercorrelational relationship between these two measures. Findings - Results show a correlational pattern that contours the evolution of a leader's skills (from novice platoon leader to expert battalion leader), with the strongest correlation at the higher leader levels. Research limitations/implications - The decision to restrict the number of TKML scenarios provided to respondents and to administer the MLQ and TKML to the same sample is considered a limitation. Practical implications - Pairing the MLQ and TKML makes use of self-reported leader behaviors with maximal assessment scales that directly assess respondents' understanding of what the best approaches to good leadership are. Social implications - Response patterns from both measures permits direct counseling on the misconceptions about leadership to create better leaders. Originality/value - No previous research has examined correlative relations among the scales/subscales of the MLQ and TKML. C1 [Taylor, Teresa Z.] Boise State Univ, Dept Psychol, Boise, ID 83725 USA. [Psotka, Joseph; Legree, Peter] US Army Res Inst Behav & Social Sci, Arlington, VA USA. RP Taylor, TZ (reprint author), Boise State Univ, Dept Psychol, Boise, ID 83725 USA. NR 61 TC 1 Z9 1 U1 4 U2 19 PU EMERALD GROUP PUBLISHING LIMITED PI BINGLEY PA HOWARD HOUSE, WAGON LANE, BINGLEY BD16 1WA, W YORKSHIRE, ENGLAND SN 0143-7739 EI 1472-5347 J9 LEADERSHIP ORG DEV J JI Leadersh. Org. Dev. J. PY 2015 VL 36 IS 2 BP 120 EP 136 DI 10.1108/LODJ-01-2013-0008 PG 17 WC Management SC Business & Economics GA CF8BO UT WOS:000352780500002 ER PT J AU Priddy, LP Doyle, JD Flintsch, GW Pittman, DW Anderton, GL AF Priddy, Lucy P. Doyle, Jesse D. Flintsch, Gerardo W. Pittman, David W. Anderton, Gary L. TI Three-dimensional modelling of precast concrete pavement repair joints SO MAGAZINE OF CONCRETE RESEARCH LA English DT Article ID FINITE-ELEMENT-ANALYSIS; PLASTIC-DAMAGE MODEL; DESIGN AB This paper examines the mechanical response of precast panel pavement repair joints under static aircraft loadings using the finite-element method. Three-dimensional finite-element models were developed using the Abaqus software code, and their results were compared to and validated against results of full-scale field tests and theoretical calculations. Unlike previous pavement repair modelling efforts for precast panels and dowel retrofitting studies, all parts of the repair joint were modelled, including the dowels, dowel slot material, parent concrete, precast panel and pavement sublayers. Results show that high stress concentrations occur in the dowel slot material and that the current panel design is likely to be improved by modifying the dowel diameter. C1 [Priddy, Lucy P.; Doyle, Jesse D.; Anderton, Gary L.] US Army ERDC, Vicksburg, MS 39180 USA. [Flintsch, Gerardo W.] Virginia Polytech Inst & State Univ, Blacksburg, VA 24061 USA. [Pittman, David W.] US Army ERDC, Geotech & Struct Lab, Vicksburg, MS USA. RP Priddy, LP (reprint author), US Army ERDC, Vicksburg, MS 39180 USA. FU US Air Force Civil Engineer Center FX Information described and presented herein, unless otherwise noted, was obtained from research sponsored by the US Air Force Civil Engineer Center and performed at the US Army Engineer Research and Development Center. Permission to publish this information was granted by the Director, Geotechnical and Structures Laboratory. NR 30 TC 0 Z9 0 U1 2 U2 11 PU ICE PUBLISHING PI WESTMINISTER PA INST CIVIL ENGINEERS, 1 GREAT GEORGE ST, WESTMINISTER SW 1P 3AA, ENGLAND SN 0024-9831 EI 1751-763X J9 MAG CONCRETE RES JI Mag. Concr. Res. PY 2015 VL 67 IS 10 BP 513 EP 522 DI 10.1680/macr.14.00278 PG 10 WC Construction & Building Technology; Materials Science, Multidisciplinary SC Construction & Building Technology; Materials Science GA CF5JL UT WOS:000352593200004 ER PT J AU Izvekov, S Rice, BM AF Izvekov, Sergei Rice, Betsy M. TI On the importance of shear dissipative forces in coarse-grained dynamics of molecular liquids SO PHYSICAL CHEMISTRY CHEMICAL PHYSICS LA English DT Article ID PARTICLE DYNAMICS; MESOSCOPIC SIMULATION; SYSTEMS; HYDRODYNAMICS; SURFACTANTS; FIELD; DPD; HMX AB In this work we demonstrate from first principles that the shear frictions describing dissipative forces in the direction normal to the vector connecting the coarse-grained (CG) particles in dissipative particle dynamics (DPD) could be dominant for certain real molecular liquids at high-resolution coarse-graining. This is in contrast to previous works on bottom-up DPD modeling and indicates that such liquids cannot be simulated accurately using the conventional form of DPD which relies only on frictions in the radial direction. Specifically, we describe the development of fully bottom-up CG models for liquid hexahydro-1,3,5-trinitro-s-triazine (RDX) which are incorporated into the DPD method. Consistent with the microscopic foundation of DPD dynamics, the conservative part of the DPD models is obtained by the multi-scale coarse-graining (MS-CG) approach, which implements the pairwise decomposition of the atomistic potential of mean force (PMF) in CG coordinates. The radial and shear distant-dependent friction coefficients in a parameter-free form are derived systematically from microscopic velocity and force correlation data along system trajectories using a recently proposed approach [J. Chem. Phys., 2014, 140, 104104]. The shear dissipative forces for the reported system appear to be dominant. We discuss the implications of dominant shear dissipation on dynamical and transport properties of CG liquids such as diffusion and viscosity as revealed by simulations of liquid RDX using the new MS-CG/DPD models. C1 [Izvekov, Sergei; Rice, Betsy M.] US Army, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Izvekov, S (reprint author), US Army, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM sergiy.izvyekov.civ@mail.mil FU DoD High Performance Computing Modernization Program Software Application Institute for Multiscale Reactive Modeling of Insensitive Munitions FX The authors wish to thank Dr John Brennan and Dr Joshua Moore of the Army Research Laboratory for helpful comments. This work was supported by the DoD High Performance Computing Modernization Program Software Application Institute for Multiscale Reactive Modeling of Insensitive Munitions. NR 69 TC 2 Z9 2 U1 2 U2 22 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1463-9076 EI 1463-9084 J9 PHYS CHEM CHEM PHYS JI Phys. Chem. Chem. Phys. PY 2015 VL 17 IS 16 BP 10795 EP 10804 DI 10.1039/c4cp06116k PG 10 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA CF7AB UT WOS:000352707200053 PM 25812678 ER PT J AU Chappell, MA Miller, LF Price, CL AF Chappell, Mark A. Miller, Lesley F. Price, Cynthia L. TI Reversible exchange of stable nitroxyl radicals on nanosilver particles SO ENVIRONMENTAL CHEMISTRY LA English DT Article DE electron spin resonance; stable radicals; ultrasonication. ID SILVER NANOPARTICLES; GOLD NANOPARTICLES; TOXICITY; CAVITATION; OH AB Radicals drive important chemical reactions in the environment. These unpaired electron species can be generated by energetic inputs, such as electromagnetic radiation, or from ultrasonication processes, whereby oxygen radicals are generated in aqueous solution through a cavitation mechanism. Previous evidence has demonstrated the potential for radicals to be stored on the surface of metallic gold nanoparticles, thus suggesting a potential transference of radical species from the nanoparticle surface for catalytic reactions, particularly during preparations of nanoparticle suspensions through ultrasonication. This work investigates the potential for the nanosilver (nAg) particles to similarly scavenge radicals from solution. nAg suspensions were reacted with 0.3-mM solutions containing the stable nitroxy radicals 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO), 4-oxo-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPONE) and 4-amino-2,2,6,6-tetramethylpiperidino-1-oxyl (TEMPAMINE) analysed by quantitative electron spin resonance (ESR) spectroscopy. In ambient air, the addition of a nAg suspension to the 0.3-mM solutions reduced the integrated ESR intensity of the stable radicals by 50-93% depending on radical species and nAg concentration, which we attributed to the sorption of the radicals onto the nAg surface. In separate experiments, the ESR intensities were further decreased under an Ar atmosphere, suggesting potential competition from ambient OH center dot to the sorption of the stable radicals. To verify this, we observed substantial increases in the integrated ESR intensity when the systems previously equilibrated under Ar atmosphere were exposed to ambient air. These results demonstrated that nAg scavenged the stable radicals from solution and were exchangeable from the metallic conduction band with OH center dot. Our work represents the first evidence for this mechanism to be demonstrated for nAg. C1 [Chappell, Mark A.; Miller, Lesley F.; Price, Cynthia L.] US Army, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Chappell, MA (reprint author), US Army, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM mark.a.chappell@usace.army.mil FU Military Materials in the Environment (MME) Program for the US Army Engineer Research & Development (ERDC) Laboratory FX This work was funded through the Military Materials in the Environment (MME) Program for the US Army Engineer Research & Development (ERDC) Laboratory. We express appreciation to Dr Elizabeth Ferguson, Technical Director of the MME Program for her support. Opinions, interpretations, conclusions and recommendations are those of the author(s) and are not necessarily endorsed by the US Army. NR 20 TC 0 Z9 0 U1 0 U2 1 PU CSIRO PUBLISHING PI CLAYTON PA UNIPARK, BLDG 1, LEVEL 1, 195 WELLINGTON RD, LOCKED BAG 10, CLAYTON, VIC 3168, AUSTRALIA SN 1448-2517 EI 1449-8979 J9 ENVIRON CHEM JI Environ. Chem. PY 2015 VL 12 IS 2 BP 198 EP 203 DI 10.1071/EN14093 PG 6 WC Chemistry, Analytical; Environmental Sciences SC Chemistry; Environmental Sciences & Ecology GA CE7EB UT WOS:000351999300012 ER PT J AU de Groot, M Doyle, T Averyt, J Risaliti, C Shubrook, J AF de Groot, Mary Doyle, Todd Averyt, Jennifer Risaliti, Carleen Shubrook, Jay TI DEPRESSIVE SYMPTOMS AND TYPE 2 DIABETES MELLITUS IN RURAL APPALACHIA: AN 18-MONTH FOLLOW-UP STUDY SO INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE LA English DT Article DE depressive symptoms; diabetes mellitus; rural ID COMORBID DEPRESSION; ADULTS; METAANALYSIS; INDIVIDUALS; ASSOCIATION; MORTALITY; QUALITY; IMPACT; WOMEN; CARE AB Objective: Despite high rates of diabetes and depression in rural areas, limited data exists to document patterns and predictors of depressive symptoms in rural patients with type 2 diabetes (T2DM). The purpose of this study was to assess the rates and predictors of co-morbid depressive symptoms over an 18-month period in a cohort of rural Appalachian adults with T2DM. Methods: N=100 adult T2DM patients were recruited from family medicine and endocrinology practices located in the rural Appalachian counties of southeastern Ohio and West Virginia. Data were collected using a longitudinal observational survey design. Results: The sample consisted of predominantly White (93%) females (62%) who were married (71%), completed high school or less (48%), and had a mean age of 60 years (SD 11). Mean BDI score was 14.0 (SD 12) with 27% scoring in the moderate/severe range for depressive symptoms. A majority of patients (77%) reported depressive symptoms, at both time points, with 88% of these reporting consistent depressive symptoms in the year prior to study follow-up. Patients with depressive symptoms at Time 1 and Time 2 did not differ from other groups in the number of treatment strategies or medications used. Predictors of depressive symptoms in this group were increased diabetes treatment complexity (OR = 2.3), lack of home ownership (OR = 11.4), and decreased satisfaction with antidepressant medications (OR = 2.0; chi(2) = 28.9, p < .0001). Conclusions: Rural T2DM patients reported high rates of repeated depressive symptoms without corresponding rates of depression treatment. These patients may benefit from close monitoring and ongoing adjustment of their treatment for depression and diabetes by primary care providers. C1 [de Groot, Mary] Indiana Univ, Indianapolis, IN 46204 USA. [Doyle, Todd] Loyola Univ, Med Ctr, Maywood, IL 60153 USA. [Averyt, Jennifer] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Risaliti, Carleen] Ohio State Univ, Sch Med, Columbus, OH 43210 USA. [Shubrook, Jay] Ohio Univ, Heritage Coll Osteopath Med, Athens, OH 45701 USA. RP de Groot, M (reprint author), Diabet Translat Res Ctr, 410 W 10th St,Suite 1140, Indianapolis, IN 46240 USA. EM mdegroot@iu.edu FU Ohio University Diabetes Research Initiative; National Institute of Diabetes, Digestive Diseases and Kidneys [R34DK071515] FX We wish to gratefully acknowledge support for this study from Ohio University Diabetes Research Initiative and the National Institute of Diabetes, Digestive Diseases and Kidneys (R34DK071515). NR 31 TC 4 Z9 4 U1 1 U2 2 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0091-2174 EI 1541-3527 J9 INT J PSYCHIAT MED JI Int. J. Psychiatr. Med. PY 2015 VL 48 IS 4 BP 263 EP 277 DI 10.2190/PM.48.4.c PG 15 WC Psychiatry SC Psychiatry GA CE9QK UT WOS:000352178300003 PM 25817523 ER PT J AU Priscoli, JD Hiroki, K AF Priscoli, Jerome Delli Hiroki, Kenzo TI Water and Disasters: Cases from the High Level Experts and Leaders Panel on Water and Disasters SO WATER POLICY LA English DT Editorial Material C1 [Priscoli, Jerome Delli] USACE, Washington, DC USA. [Hiroki, Kenzo] MLIT, Dept Water Resources, Tsukuba, Ibaraki, Japan. NR 11 TC 0 Z9 0 U1 2 U2 5 PU IWA PUBLISHING PI LONDON PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND SN 1366-7017 J9 WATER POLICY JI Water Policy PY 2015 VL 17 SU 1 BP 1 EP 5 DI 10.2166/wp.2015.000 PG 5 WC Water Resources SC Water Resources GA CF5AV UT WOS:000352567800001 ER PT S AU Kashinski, DO Talbi, D Hickman, AP AF Kashinski, D. O. Talbi, D. Hickman, A. P. BE Schneider, IF Dulieu, O Robert, J TI Using block diagonalization to determine dissociating autoionizing states: Application to N2H, and the outlook for SH SO DR2013: NINTH INTERNATIONAL CONFERENCE ON DISSOCIATIVE RECOMBINATION: THEORY, EXPERIMENT, AND APPLICATIONS SE EPJ Web of Conferences LA English DT Proceedings Paper CT 9th International Conference on Dissociative Recombination: Theory, Experiment, and Applications CY JUL 07-12, 2013 CL Paris, FRANCE ID DIABATIC STATES; RECOMBINATION; ABSORPTION; SYSTEM AB We describe our implementation of the block diagonalization method for calculating the potential surfaces necessary to treat dissociative recombination (DR) of electrons with N2H+. Using the methodology we have developed over the past few years, we performed multi- reference, configuration interaction calculations for N2H+ and N2H with a large active space using the GAMESS electronic structure code. We treated both linear and bent geometries of the molecules, with N-2 fixed at its equilibrium separation. Because of the strong Rydberg-valence coupling in N2H, it is essential to isolate the appropriate dissociating, autoionizing states. Our procedure requires only modest additional effort beyond the standard methodology. The results indicate that the crossing between the dissociating neutral curve and the initial ion potential is not favorably located for DR, even if the molecule bends. The present calculations thereby confirm our earlier results for linear N2H and reinforce the conclusion that the direct mechanism for DR is likely to be inefficient. We also describe interesting features of our preliminary calculations on SH. C1 [Kashinski, D. O.] US Mil Acad, Dept Phys & Nucl Engn, West Point, NY 10996 USA. [Talbi, D.] Univ Montpellier 2, Lab Univers & Particules Montpellier, UMR 5299, F-34095 Montpellier, France. [Hickman, A. P.] Lehigh Univ, Dept Phys, Bethlehem, PA 18015 USA. RP Kashinski, DO (reprint author), US Mil Acad, Dept Phys & Nucl Engn, West Point, NY 10996 USA. EM david.kashinski@usma.edu; dahbia.talbi@univ-montp2.fr; aph2@lehigh.edu NR 16 TC 1 Z9 1 U1 0 U2 1 PU E D P SCIENCES PI CEDEX A PA 17 AVE DU HOGGAR PARC D ACTIVITES COUTABOEUF BP 112, F-91944 CEDEX A, FRANCE SN 2100-014X J9 EPJ WEB CONF PY 2015 VL 84 AR 03003 DI 10.1051/epjconf/20158403003 PG 9 WC Chemistry, Physical; Physics, Multidisciplinary SC Chemistry; Physics GA BC3PG UT WOS:000351835100010 ER PT J AU Lu, Z Wang, WY Wang, C AF Lu, Zhuo Wang, Wenye Wang, Cliff TI Camouflage Traffic: Minimizing Message Delay for Smart Grid Applications under Jamming SO IEEE TRANSACTIONS ON DEPENDABLE AND SECURE COMPUTING LA English DT Article DE Smart grid; wireless applications; performance modeling; worst-case analysis; message delay; jamming attacks ID NETWORKS; SYSTEMS AB Smart grid is a cyber-physical system that integrates power infrastructures with information technologies. To facilitate efficient information exchange, wireless networks have been proposed to be widely used in the smart grid. However, the jamming attack that constantly broadcasts radio interference is a primary security threat to prevent the deployment of wireless networks in the smart grid. Hence, spread spectrum systems, which provide jamming resilience via multiple frequency and code channels, must be adapted to the smart grid for secure wireless communications, while at the same time providing latency guarantee for control messages. An open question is how to minimize message delay for timely smart grid communication under any potential jamming attack. To address this issue, we provide a paradigm shift from the case-by-case methodology, which is widely used in existing works to investigate well-adopted attack models, to the worst-case methodology, which offers delay performance guarantee for smart grid applications under any attack. We first define a generic jamming process that characterizes a wide range of existing attack models. Then, we show that in all strategies under the generic process, the worst-case message delay is a U-shaped function of network traffic load. This indicates that, interestingly, increasing a fair amount of traffic can in fact improve the worst-case delay performance. As a result, we demonstrate a lightweight yet promising system, transmitting adaptive camouflage traffic (TACT), to combat jamming attacks. TACT minimizes the message delay by generating extra traffic called camouflage to balance the network load at the optimum. Experiments show that TACT can decrease the probability that a message is not delivered on time in order of magnitude. C1 [Lu, Zhuo; Wang, Wenye] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27606 USA. [Wang, Cliff] Army Res Off, Comp Sci, Res Triangle Pk, NC USA. RP Lu, Z (reprint author), N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27606 USA. EM zlu3@ncsu.edu; wwang@ncsu.edu; cliff.wang@us.army.mil FU Army Research Office (ARO) staff research grant [W911NF-07-R-0001-05]; National science Foundation (NSF) Career Award [CNS-0546289] FX The work was supported by Army Research Office (ARO) staff research grant W911NF-07-R-0001-05 and National science Foundation (NSF) Career Award CNS-0546289. Part of the work was presented in IEEE INFOCOM'12. NR 27 TC 2 Z9 2 U1 1 U2 4 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1545-5971 EI 1941-0018 J9 IEEE T DEPEND SECURE JI IEEE Trans. Dependable Secur. Comput. PD JAN-FEB PY 2015 VL 12 IS 1 BP 31 EP 44 DI 10.1109/TDSC.2014.2316795 PG 14 WC Computer Science, Hardware & Architecture; Computer Science, Information Systems; Computer Science, Software Engineering SC Computer Science GA CE7XC UT WOS:000352054200003 ER PT J AU Hohenforst-Schmidt, W Zarogoulidis, P Stopek, J Kosmidis, E Vogl, T Linsmeier, B Tsakiridis, K Lampaki, S Lazaridis, G Mpakas, A Browning, R Papaiwannou, A Drevelegas, A Baka, S Karavasilis, V Mpoukovinas, I Turner, JF Zarogoulidis, K Brachmann, J AF Hohenforst-Schmidt, Wolfgang Zarogoulidis, Paul Stopek, Joshua Kosmidis, Efstratios Vogl, Thomas Linsmeier, Bernd Tsakiridis, Kosmas Lampaki, Sofia Lazaridis, George Mpakas, Andreas Browning, Robert Papaiwannou, Antonis Drevelegas, Antonis Baka, Sofia Karavasilis, Vasilis Mpoukovinas, Ioannis Turner, J. Francis Zarogoulidis, Konstantinos Brachmann, Johannes TI Enhancement of Intratumoral Chemotherapy with Cisplatin with or without Microwave Ablation and Lipiodol. Future Concept for Local Treatment in Lung Cancer SO JOURNAL OF CANCER LA English DT Article DE lung cancer; intratumoral; lipiodol; cisplatin; microwave ablation ID COMBINED RADIOFREQUENCY ABLATION; LIPOSOMAL DOXORUBICIN; LIVER METASTASES; GENE-THERAPY; CARCINOMA; SYSTEM; SIZE AB Novel therapies for lung cancer are being explored nowadays with local therapies being the tip of the arrow. Intratumoral chemotherapy administration and local microwave ablation have been investigated in several studies. It has been previously proposed that lipiodol has the ability to modify the microenvironment matrix. In our current study we investigated this theory in BALBC mice. In total 160 BALBC mice were divided in eight groups: a) control, b) cisplatin, c) microwave, d) microwave and lipiodol, e) cisplatin and lipiodol, f) microwave and cisplatin, g) lipiodol and h) lipiodol, cisplatin and microwave. Lewis lung carcinoma cell lines (10(6)) were injected into the right back leg of each mouse. After the 8th day, when the tumor volume was about 100mm(3) the therapy application was initiated, once per week for four weeks. Magnetic resonance imaging was performed for each tumor when a mouse died or when sacrificed if they were still alive by the end of the experiment (8-Canal multifunctional spool; NORAS MRI products, Gmbh, Germany). Imaging and survival revealed efficient tumor apoptosis for the groups b, c, d, e and f. However; severe toxicity was observed in group h and no follow up was available for this group after the second week of therapy administration. Lipiodol in its current form does assist in a more efficient way the distribution of cisplatin, as the microwave apoptotic effect. Future modification of lipiodol might provide a more efficient method of therapy enhancement. Combination of drug and microwave ablation is possible and has an efficient apoptotic effect. C1 [Hohenforst-Schmidt, Wolfgang; Brachmann, Johannes] Univ Wurzburg, Coburg Hosp, Med Clin 2, Coburg, Germany. [Zarogoulidis, Paul; Lampaki, Sofia; Papaiwannou, Antonis; Zarogoulidis, Konstantinos] Aristotle Univ Thessaloniki, G Papanikolaou Gen Hosp, Dept Pulm, Oncol Unit, GR-54006 Thessaloniki, Greece. [Stopek, Joshua] Covidien, Minneapolis, MN USA. [Kosmidis, Efstratios] Aristotle Univ Thessaloniki, Sch Vet, GR-54006 Thessaloniki, Greece. [Vogl, Thomas] Goethe Univ Frankfurt, Dept Diagnost & Intervent Radiol, D-60054 Frankfurt, Germany. [Linsmeier, Bernd] Medinos Clin Sonneberg, Dept Thorac Surg, Sonnerberg, Germany. [Tsakiridis, Kosmas; Mpakas, Andreas] St Luke Private Hosp, Dept Thorac Surg, Thessaloniki, Greece. [Lazaridis, George; Karavasilis, Vasilis] Aristotle Univ Thessaloniki, Papageorgiou Gen Hosp, Dept Oncol, GR-54006 Thessaloniki, Greece. [Browning, Robert] Walter Reed Army Med Ctr, Pulm & Crit Care Med, Intervent Pulmonol, Natl Naval Med Ctr, Bethesda, MD USA. [Drevelegas, Antonis] Interbalkan European Med Ctr, Dept Radiol, Thessaloniki, Greece. [Baka, Sofia] Interbalkan European Med Ctr, Dept Oncol, Thessaloniki, Greece. [Mpoukovinas, Ioannis] BioMed Clin, Dept Oncol, Thessaloniki, Greece. [Turner, J. Francis] Western Reg Med Ctr, Canc Treatment Centers Amer, Div Intervent Pulmonol & Med Oncol 2, Goodyear, AZ USA. RP Zarogoulidis, P (reprint author), Aristotle Univ Thessaloniki, G Papanikolaou Gen Hosp, Dept Pulm, Oncol Unit, GR-54006 Thessaloniki, Greece. EM pzarog@hotmail.com NR 38 TC 1 Z9 2 U1 0 U2 4 PU IVYSPRING INT PUBL PI LAKE HAVEN PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA SN 1837-9664 J9 J CANCER JI J. Cancer PY 2015 VL 6 IS 3 BP 218 EP 226 DI 10.7150/jca.10970 PG 9 WC Oncology SC Oncology GA CE9BK UT WOS:000352138200002 PM 25663938 ER PT J AU Jain, RB Choi, YS AF Jain, Ram B. Choi, Y. Sammy TI Normal reference ranges for and variability in the levels of blood manganese and selenium by gender, age, and race/ethnicity for general US population SO JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY LA English DT Article DE Manganese; Selenium; Smoking; Gender; Race/ethnicity ID CAFFEINE CONSUMPTION; DRINKING-WATER; EXPOSURE; TOXICITY; CHILDREN; DEFICIENCY; EXPRESSION; BIPHENYLS; SMOKING; CANCER AB Data from National Health and Nutrition Examination Survey for the period 2011-2012 were used to determine normal reference ranges and percentile distributions for manganese (Mn) and selenium (Se) in blood by gender, age, race/ethnicity, socioeconomic status as determined by annual family income, and smoking status. The effect of gender, age, race/ethnicity, family income, and smoking status on the levels of Mn and Se was also determined by fitting regression models. Males had lower adjusted levels of Mn and higher adjusted levels of Se than females. Adjusted levels of Mn decreased with increase in age but adjusted levels of Se were lower in adolescents aged 12-19 years than adults aged 20-64 years. Non-Hispanic black (NHB) had the lowest levels of both Mn and Se and non-Hispanic Asians (NHAS) had the highest levels of both Mn and Se. Non-Hispanic white (NHW) and NHB had lower levels of Mn than Hispanics (HISP) and NHAS. NHB and HISP had lower levels of Se than NHW and NHAS. Low annual income (<$20,000) was associated with lower levels of Se than high annual income (>=$55,000). Smoking negatively affected the adjusted levels of Se among seniors aged >= 65 years but this was not observed in other age groups. Mn levels were not affected by smoking. Published by Elsevier GmbH. C1 [Jain, Ram B.; Choi, Y. Sammy] Womack Army Med Ctr, Ft Bragg, NC 28310 USA. [Jain, Ram B.] Empiristat Inc, Mt Airy, MD USA. RP Jain, RB (reprint author), Womack Army Med Ctr, 2817 Reilly Rd, Ft Bragg, NC 28310 USA. EM ram.b.jain.ctr@mail.mil NR 35 TC 5 Z9 5 U1 1 U2 5 PU ELSEVIER GMBH, URBAN & FISCHER VERLAG PI JENA PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY SN 0946-672X J9 J TRACE ELEM MED BIO JI J. Trace Elem. Med. Biol. PY 2015 VL 30 BP 142 EP 152 DI 10.1016/j.jtemb.2014.12.004 PG 11 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism SC Biochemistry & Molecular Biology; Endocrinology & Metabolism GA CE4LL UT WOS:000351802000024 PM 25596656 ER PT B AU Thompson, AS Frentzos, CG AF Thompson, Antonio S. Frentzos, Christos G. BE Thompson, AS Frentzos, CG TI THE ROUTLEDGE HANDBOOK OF AMERICAN MILITARY AND DIPLOMATIC HISTORY The Colonial Period to 1877 INTRODUCTION SO ROUTLEDGE HANDBOOK OF AMERICAN MILITARY AND DIPLOMATIC HISTORY: THE COLONIAL PERIOD TO 1877 LA English DT Editorial Material; Book Chapter C1 [Thompson, Antonio S.] USMA, West Point, NY USA. [Frentzos, Christos G.] Austin Peay State Univ, Clarksville, TN 37044 USA. [Frentzos, Christos G.] US Mil Acad, Summer Mil Hist Seminar, West Point, NY USA. [Frentzos, Christos G.] Tel Aviv Univ, Fdn Def Democracies Terrorism Studies Program, IL-69978 Tel Aviv, Israel. RP Thompson, AS (reprint author), Austin Peay State Univ, Clarksville, TN 37044 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE PI ABINGDON PA 2 PARK SQ, MILTON PARK, ABINGDON OX14 4RN, OXFORD, ENGLAND BN 978-1-315-81734-7; 978-0-415-53380-5 PY 2015 BP 1 EP 6 PG 6 WC History SC History GA BB9SG UT WOS:000348591300001 ER PT B AU Warren, J AF Warren, Jason BE Thompson, AS Frentzos, CG TI THE SPIRIT OF '76 King Philip's War and Bacon's Rebellion, 1675-1676 SO ROUTLEDGE HANDBOOK OF AMERICAN MILITARY AND DIPLOMATIC HISTORY: THE COLONIAL PERIOD TO 1877 LA English DT Article; Book Chapter C1 [Warren, Jason] US Army War Coll, Carlisle, PA USA. NR 22 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE PI ABINGDON PA 2 PARK SQ, MILTON PARK, ABINGDON OX14 4RN, OXFORD, ENGLAND BN 978-1-315-81734-7; 978-0-415-53380-5 PY 2015 BP 42 EP 50 PG 9 WC History SC History GA BB9SG UT WOS:000348591300006 ER PT B AU Leeman, WP AF Leeman, William P. BE Thompson, AS Frentzos, CG TI WAR WITHOUT DECLARATION The Barbary Wars SO ROUTLEDGE HANDBOOK OF AMERICAN MILITARY AND DIPLOMATIC HISTORY: THE COLONIAL PERIOD TO 1877 LA English DT Article; Book Chapter C1 [Leeman, William P.] Salve Regina Univ, Newport, RI 02840 USA. [Leeman, William P.] Salve Regina Univ, Pell Ctr Int Relat & Publ Policy, Newport, RI USA. [Leeman, William P.] US Mil Acad, West Point, NY USA. RP Leeman, WP (reprint author), Salve Regina Univ, Newport, RI 02840 USA. NR 17 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE PI ABINGDON PA 2 PARK SQ, MILTON PARK, ABINGDON OX14 4RN, OXFORD, ENGLAND BN 978-1-315-81734-7; 978-0-415-53380-5 PY 2015 BP 164 EP 171 PG 8 WC History SC History GA BB9SG UT WOS:000348591300020 ER PT B AU Watson, S AF Watson, Samuel BE Thompson, AS Frentzos, CG TI FLORIDA FORAYS, FIASCOS, AND CONQUESTS Andrew Jackson, John Quincy Adams, and the First Seminole War SO ROUTLEDGE HANDBOOK OF AMERICAN MILITARY AND DIPLOMATIC HISTORY: THE COLONIAL PERIOD TO 1877 LA English DT Article; Book Chapter C1 US Mil Acad, West Point, NY 10996 USA. RP Watson, S (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 42 TC 0 Z9 0 U1 1 U2 1 PU ROUTLEDGE PI ABINGDON PA 2 PARK SQ, MILTON PARK, ABINGDON OX14 4RN, OXFORD, ENGLAND BN 978-1-315-81734-7; 978-0-415-53380-5 PY 2015 BP 233 EP 240 PG 8 WC History SC History GA BB9SG UT WOS:000348591300028 ER PT B AU Spahr, TW AF Spahr, Thomas W. BE Thompson, AS Frentzos, CG TI THE MEXICAN-AMERICAN WAR A Historiographical Overview SO ROUTLEDGE HANDBOOK OF AMERICAN MILITARY AND DIPLOMATIC HISTORY: THE COLONIAL PERIOD TO 1877 LA English DT Article; Book Chapter C1 [Spahr, Thomas W.] 4th Brigade Combat Team, New York, NY USA. [Spahr, Thomas W.] 82nd Airborne Div, Ft Bragg, NC USA. Southern Afghanistan, Kabul, Afghanistan. [Spahr, Thomas W.] 7th Special Forces Grp, New York, NY USA. [Spahr, Thomas W.] 75th Ranger Regiment, Ft Benning, GA USA. RP Spahr, TW (reprint author), The Army, Washington, DC 20001 USA. NR 37 TC 0 Z9 0 U1 0 U2 1 PU ROUTLEDGE PI ABINGDON PA 2 PARK SQ, MILTON PARK, ABINGDON OX14 4RN, OXFORD, ENGLAND BN 978-1-315-81734-7; 978-0-415-53380-5 PY 2015 BP 259 EP 266 PG 8 WC History SC History GA BB9SG UT WOS:000348591300031 ER PT J AU Joyner, MJ Barnes, JN Hart, EC Wallin, BG Charkoudian, N AF Joyner, Michael J. Barnes, Jill N. Hart, Emma C. Wallin, B. Gunnar Charkoudian, Nisha TI Neural Control of the Circulation: How Sex and Age Differences Interact in Humans SO COMPREHENSIVE PHYSIOLOGY LA English DT Article ID SYMPATHETIC-NERVE ACTIVITY; ARTERIAL-BLOOD-PRESSURE; BODY NEGATIVE-PRESSURE; HEART-RATE-VARIABILITY; GENDER-DIFFERENCES; HEALTHY HUMANS; NITRIC-OXIDE; NORADRENALINE SPILLOVER; BAROREFLEX SENSITIVITY; AUTONOMIC SUPPORT AB The autonomic nervous system is a key regulator of the cardiovascular system. In this review, we focus on how sex and aging influence autonomic regulation of blood pressure in humans in an effort to understand general issues related to the cardiovascular system as a whole. Younger women generally have lower blood pressure and sympathetic activity than younger men. However, both sexes show marked interindividual variability across age groups with significant overlap seen. Additionally, while men across the lifespan show a clear relationship between markers of whole body sympathetic activity and vascular resistance, such a relationship is not seen in young women. In this context, the ability of the sympathetic nerves to evoke vasoconstriction is lower in young women likely as a result of concurrent beta(2)-mediated vasodilation that offsets alpha-adrenergic vasoconstriction. These differences reflect both central sympatho-inhibitory effects of estrogen and also its influence on peripheral vasodilation at the level of the vascular smooth muscle and endothelium. By contrast postmenopausal women show a clear relationship between markers of whole body sympathetic traffic and vascular resistance, and sympathetic activity rises progressively in both sexes with aging. These major findings in humans are discussed in the context of differences in population-based trends in blood pressure and orthostatic intolerance. The many areas where there is little sex-specific data on how the autonomic nervous system participates in the regulation of the human cardiovascular system are highlighted. (C) 2015 American Physiological Society. C1 [Joyner, Michael J.; Barnes, Jill N.] Mayo Clin, Dept Anesthesiol, Rochester, MN 55902 USA. [Hart, Emma C.] Univ Bristol, Sch Physiol & Pharmacol, Bristol, Avon, England. [Wallin, B. Gunnar] Gothenburg Univ, Sahlgren Acad, Inst Neurosci & Physiol, Gothenburg, Sweden. [Charkoudian, Nisha] US Army Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA USA. RP Joyner, MJ (reprint author), Mayo Clin, Dept Anesthesiol, Rochester, MN 55902 USA. EM joyner.michael@mayo.edu OI Hart, Emma/0000-0002-4534-9586 FU British Heart Foundation [FS/11/1/28400]; NCATS NIH HHS [UL1 TR000135]; NHLBI NIH HHS [HL-83947, R01 HL083947]; NIA NIH HHS [AG 38067, F32 AG038067] NR 119 TC 20 Z9 20 U1 2 U2 9 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 2040-4603 J9 COMPR PHYSIOL JI Compr. Physiol. PD JAN PY 2015 VL 5 IS 1 BP 193 EP 215 DI 10.1002/cphy.c140005 PG 23 WC Physiology SC Physiology GA CE0JS UT WOS:000351490900008 PM 25589269 ER PT J AU Bhat, S Motz, LH Pathak, C Kuebler, L AF Bhat, Shirish Motz, Louis H. Pathak, Chandra Kuebler, Laura TI Geostatistics-based groundwater-level monitoring network design and its application to the Upper Floridan aquifer, USA SO ENVIRONMENTAL MONITORING AND ASSESSMENT LA English DT Article DE Groundwater-level monitoring; Groundwater well network design; Groundwater management; Salinity-adjusted heads; Geostatistics; Kriging; South Florida ID SPATIAL VARIABILITY; OPTIMIZATION; CHINA; TIME; SPACE; DEPTH AB A geostatistical method was applied to optimize an existing groundwater-level monitoring network in the Upper Floridan aquifer for the South Florida Water Management District in the southeastern United States. Analyses were performed to determine suitable numbers and locations of monitoring wells that will provide equivalent or better quality groundwater-level data compared to an existing monitoring network. Ambient, unadjusted groundwater heads were expressed as salinity-adjusted heads based on the density of freshwater, well screen elevations, and temperature-dependent saline groundwater density. The optimization of the numbers and locations of monitoring wells is based on a pre-defined groundwater-level prediction error. The newly developed network combines an existing network with the addition of new wells that will result in a spatial distribution of groundwater monitoring wells that better defines the regional potentiometric surface of the Upper Floridan aquifer in the study area. The network yields groundwater-level predictions that differ significantly from those produced using the existing network. The newly designed network will reduce the mean prediction standard error by 43 % compared to the existing network. The adoption of a hexagonal grid network for the South Florida Water Management District is recommended to achieve both a uniform level of information about groundwater levels and the minimum required accuracy. It is customary to install more monitoring wells for observing groundwater levels and groundwater quality as groundwater development progresses. However, budget constraints often force water managers to implement cost-effective monitoring networks. In this regard, this study provides guidelines to water managers concerned with groundwater planning and monitoring. C1 [Bhat, Shirish; Motz, Louis H.] Univ Florida, Dept Civil & Coastal Engn, Gainesville, FL 32611 USA. [Pathak, Chandra] US Army Corps Engineers, Headquarters, Washington, DC USA. [Kuebler, Laura] South Florida Water Management Dist, Div Water Resources, Hydrol & Environm Syst Modeling Sect, W Palm Beach, FL USA. RP Bhat, S (reprint author), Univ Florida, Dept Civil & Coastal Engn, Gainesville, FL 32611 USA. EM shirish.bhat@gmail.com FU South Florida Water Management District, West Palm Beach Florida [4500057295] FX The authors would like to thank Peter Kwiatkowski, Emily Richardson, Cindy Bevier, Ceyda Polatel, and Kevin Zhu with the South Florida Water Management District for their invaluable review comments and suggestions. Financial support for this project was provided by the South Florida Water Management District, West Palm Beach Florida, by means of Purchase Order 4500057295. NR 35 TC 3 Z9 3 U1 3 U2 16 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0167-6369 EI 1573-2959 J9 ENVIRON MONIT ASSESS JI Environ. Monit. Assess. PD JAN PY 2015 VL 187 IS 1 AR 4183 DI 10.1007/s10661-014-4183-x PG 15 WC Environmental Sciences SC Environmental Sciences & Ecology GA CE0YB UT WOS:000351535800006 PM 25433546 ER PT J AU Kesavan, J Sagripanti, JL AF Kesavan, Jana Sagripanti, Jose-Luis TI Evaluation criteria for bioaerosol samplers SO ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS LA English DT Article ID AEROSOL SAMPLERS; PERFORMANCE; PARTICLES; BACTERIAL; TESTS AB Humans contract a variety of serious diseases through inhalation of infectious aerosols. Thus, the importance of monitoring air for microbial, toxic, or allergic content is recognized in clinical, occupational, and biodefense arenas. However, accurate monitoring of potentially contaminated environments can be hampered by selection of aerosol samplers with inadequate performance for the intended task. In this study, 29 aerosol samplers were evaluated based on their respective air flow, size, weight, power consumption, and efficiency in sampling particles in the respirable range. The resulting data demonstrates that sampling air flow and efficiency vary widely, and cannot be predicted from the physical characteristics of air samplers, and hence, that proper selection of air samplers should be more involved than shopping for a device based on the limited characteristics that are published by the manufacturers. The findings are summarized in an approach to rationally select bioaerosol samplers for use in infection control and environmental biomonitoring. The presented data demonstrates that inadequate selection of air samplers could result in a failure to collect particles of interest and thus, underestimate the risk and provide a false sense of security in contaminated health care settings and environments contaminated with infectious or toxic aerosols. C1 [Kesavan, Jana; Sagripanti, Jose-Luis] US Army Edgewood Chem Biol Ctr, RDCB DRI A, Aberdeen Proving Ground, MD 21010 USA. RP Kesavan, J (reprint author), US Army Edgewood Chem Biol Ctr, RDCB DRI A, E5951,5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM Jana.Kesavan@us.army.mil FU Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland FX The project was funded by the Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland. NR 28 TC 4 Z9 4 U1 6 U2 32 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2050-7887 EI 2050-7895 J9 ENVIRON SCI-PROC IMP JI Environ. Sci.-Process Impacts PY 2015 VL 17 IS 3 BP 638 EP 645 DI 10.1039/c4em00510d PG 8 WC Chemistry, Analytical; Environmental Sciences SC Chemistry; Environmental Sciences & Ecology GA CD9TM UT WOS:000351441300014 PM 25631321 ER PT J AU Su, W AF Su, Wei TI Modulation Classification of Single-Input Multiple-Output Signals Using Asynchronous Sensors SO IEEE SENSORS JOURNAL LA English DT Article DE Cognitive radio; distributed sensors; high-order statistics; modulation classification; spectrum sensing; sensor network; single-input multiple-output ID CYCLIC CUMULANTS; FADING CHANNELS; LIKELIHOOD AB This paper discusses the automatic modulation classification of weak communication signals using distributed low-cost sensors. The concept of a secondary user in sensor networks is presented and very high-order statistics are used as modulation features. Two feature-based methods, single-variable and multivariable modulation classifiers, are proposed for estimating unknown modulation schemes through single-input multiple-output signal sensing channels. The new approaches acquire multiple signal observations collected from distributed sensors and leverage the channel diversity to enhance signal power and reduce bias in estimation. The experiment demonstrates that the network centric modulation classifier achieves significantly improved performance in terms of probability of correct classification than the current state-of-the-art single sensor modulation classifier, and the multivariable modulation classifier is more robust to the channel parameter variations than the single-variable classifier. C1 US Army, Commun Elect Res Dev & Engn Ctr, Aberdeen, MD 21001 USA. RP Su, W (reprint author), US Army, Commun Elect Res Dev & Engn Ctr, Aberdeen, MD 21001 USA. EM wei.su@ieee.org NR 49 TC 2 Z9 2 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1530-437X EI 1558-1748 J9 IEEE SENS J JI IEEE Sens. J. PD JAN PY 2015 VL 15 IS 1 BP 346 EP 357 DI 10.1109/JSEN.2014.2343832 PG 12 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA CD6SR UT WOS:000351220200007 ER PT J AU Hoole, SRH Karthik, VU Sivasuthan, S Rahunanthan, A Thyagarajan, RS Jayakumar, P AF Hoole, S. Ratnajeevan H. Karthik, Victor U. Sivasuthan, Sivamayam Rahunanthan, Arunasalam Thyagarajan, Ravi S. Jayakumar, Paramsothy TI Finite elements, design optimization, and nondestructive evaluation: A review in magnetics, and future directions in GPU-based, element-by-element coupled optimization and NDE SO INTERNATIONAL JOURNAL OF APPLIED ELECTROMAGNETICS AND MECHANICS LA English DT Article DE Review; optimization; finite elements; GPU; NDE; ground vehicles ID EDDY-CURRENT NDT; CONSTRAINED OPTIMIZATION; ELECTROMAGNETIC DEVICES; MULTIOBJECTIVE OPTIMIZATION; GEOMETRIC PARAMETRIZATION; MAGNETOSTATIC PROBLEMS; SYNCHRONOUS MACHINES; GRAPHICS PROCESSORS; ALGORITHM; FIELD AB This paper reviews mathematical optimization in synthesis and nondestructive evaluation (NDE) by the finite element method in magnetics because background work has been inadequately attributed in the literature. The review identifies the earliest papers and reports new work in nondestructive evaluation and GPU-based matrix solution to save time and memory. Although the genetic algorithm has been applied in optimization, in coupled systems the number of object function evaluations doubles. We therefore examine the use of graphics processing units (GPUs) to handle the immense computational load. GPU memory limits are often not recognized and are critically limiting when parallelizing the several solutions required in optimization. To overcome this limit, element-by-element finite element matrix processing is employed, making coupled problems practicable on GPUs. We overcome the memory limits element-by-element processing, however, and achieve a GPU speedup of 147 by Jacobi conjugate gradients while forming the matrix of coefficients and of 80 (and growing indefinitely) by Gauss iterations without forming the matrix for situations where memory is scarce such as genetic algorithm optimization where several copies of the matrix have to be held on threads. C1 [Hoole, S. Ratnajeevan H.; Karthik, Victor U.; Sivasuthan, Sivamayam] Michigan State Univ, Dept Elect & Comp Engn, E Lansing, MI 48824 USA. [Rahunanthan, Arunasalam] Univ Toledo, Dept Math & Stat, Toledo, OH 43606 USA. [Thyagarajan, Ravi S.; Jayakumar, Paramsothy] US Army Tank Automot Res Dev & Engn Ctr, Warren, MI USA. RP Hoole, SRH (reprint author), Michigan State Univ, Dept Elect & Comp Engn, 2120 Engn Bldg,428 South Shaw Lane, E Lansing, MI 48824 USA. EM srhhoole@gmail.com FU US Army's Tank, Automotive Research, Development and Engineering Center (TARDEC) [W911NF-11-D-0001] FX This work was funded in part by the US Army's Tank, Automotive Research, Development and Engineering Center (TARDEC) under contract number W911NF-11-D-0001. NR 81 TC 3 Z9 3 U1 2 U2 11 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 1383-5416 EI 1875-8800 J9 INT J APPL ELECTROM JI Int. J. Appl. Electromagn. Mech. PY 2015 VL 47 IS 3 BP 607 EP 627 DI 10.3233/JAE-140061 PG 21 WC Engineering, Electrical & Electronic; Mechanics; Physics, Applied SC Engineering; Mechanics; Physics GA CD5SZ UT WOS:000351149600003 ER PT J AU Fu, RX Toonen, RC Hirsch, SG Ivill, MP Cole, MW Strawhecker, KE AF Fu, Richard X. Toonen, Ryan C. Hirsch, Samuel G. Ivill, Mathew P. Cole, Melanie W. Strawhecker, Kenneth E. TI Fabrication of self-aligned, nanoscale, complex oxide varactors SO JOURNAL OF MICRO-NANOLITHOGRAPHY MEMS AND MOEMS LA English DT Article DE barium strontium titanate; e-beam lithography; inductively coupled plasma etch ID THIN-FILMS; PLASMA; SIZE AB Applications in ferroelectric random access memory and superparaelectric devices require the fabrication of ferroelectric capacitors at the nanoscale that exhibit extremely small leakage currents. To systematically study the material-size dependence of ferroelectric varactor performance, arrays of parallel-plate structures have been fabricated with nanoscale dielectric diameters. Electron beam lithography and inductively coupled plasma dry etching have been used to fabricate arrays of ferroelectric varactors using top electrodes as a self-aligned etch mask. Parallel-plate test structures using RF-sputtered Ba0.6Sr0.4TiO3 thin-films were used to optimize the fabrication process. Varactors with diameters down to 20 nm were successfully fabricated. Current-voltage (I-V) characteristics were measured to evaluate the significance of etch-damage and fabrication quality by ensuring low leakage currents through the structures. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE) C1 [Fu, Richard X.; Hirsch, Samuel G.; Ivill, Mathew P.; Cole, Melanie W.; Strawhecker, Kenneth E.] US Army Res Lab, Adelphi, MD 20783 USA. [Toonen, Ryan C.] Univ Akron, Dept Elect & Comp Engn, ASEC 555, Akron, OH 44325 USA. RP Fu, RX (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM richard.x.fu.civ@mail.mil FU U.S. Army Research Laboratory (ARL) Director's Research Initiatives [FY12-WMR-050] FX The authors would like to thank Dr. Madhumita Roy and Dr. Justin Bickford for their contributions toward e-beam lithography nanostructure fabrication. Funding for this work was supported by U.S. Army Research Laboratory (ARL) Director's Research Initiatives (FY12-WMR-050). NR 19 TC 0 Z9 0 U1 6 U2 9 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 1932-5150 EI 1932-5134 J9 J MICRO-NANOLITH MEM JI J. Micro-Nanolithogr. MEMS MOEMS PD JAN PY 2015 VL 14 IS 1 AR UNSP 013508 DI 10.1117/1.JMM.14.1.013508 PG 5 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Optics SC Engineering; Science & Technology - Other Topics; Materials Science; Optics GA CE2IZ UT WOS:000351640600016 ER PT J AU Kugelman, JR Sanchez-Lockhart, M Andersen, KG Gire, S Park, DJ Sealfon, R Lin, AE Wohl, S Sabeti, PC Kuhn, JH Palacios, GF AF Kugelman, Jeffrey R. Sanchez-Lockhart, Mariano Andersen, Kristian G. Gire, Stephen Park, Daniel J. Sealfon, Rachel Lin, Aaron E. Wohl, Shirlee Sabeti, Pardis C. Kuhn, Jens H. Palacios, Gustavo F. TI Evaluation of the Potential Impact of Ebola Virus Genomic Drift on the Efficacy of Sequence-Based Candidate Therapeutics SO MBIO LA English DT Article ID NONHUMAN-PRIMATES; POSTEXPOSURE PROTECTION; MONOCLONAL-ANTIBODIES; MORPHOLINO OLIGOMERS; RNA INTERFERENCE; ZAIRE-EBOLAVIRUS; INFECTION; VARIANTS; DISEASE; NOMENCLATURE AB Until recently, Ebola virus (EBOV) was a rarely encountered human pathogen that caused disease among small populations with extraordinarily high lethality. At the end of 2013, EBOV initiated an unprecedented disease outbreak in West Africa that is still ongoing and has already caused thousands of deaths. Recent studies revealed the genomic changes this particular EBOV variant undergoes over time during human-to-human transmission. Here we highlight the genomic changes that might negatively impact the efficacy of currently available EBOV sequence-based candidate therapeutics, such as small interfering RNAs (siRNAs), phosphorodiamidate morpholino oligomers (PMOs), and antibodies. Ten of the observed mutations modify the sequence of the binding sites of monoclonal antibody (MAb) 13F6, MAb 1H3, MAb 6D8, MAb 13C6, and siRNA EK-1, VP24, and VP35 targets and might influence the binding efficacy of the sequence-based therapeutics, suggesting that their efficacy should be reevaluated against the currently circulating strain. C1 [Kugelman, Jeffrey R.; Sanchez-Lockhart, Mariano; Palacios, Gustavo F.] US Army Med Res Inst Infect Dis, Ctr Genome Sci Div, Frederick, MD 21702 USA. [Andersen, Kristian G.; Gire, Stephen; Park, Daniel J.; Lin, Aaron E.; Wohl, Shirlee; Sabeti, Pardis C.] Harvard Univ, Ctr Syst Biol, Cambridge, MA 02138 USA. [Sealfon, Rachel] MIT, Comp Sci & Artificial Intelligence Lab, Cambridge, MA 02139 USA. [Kuhn, Jens H.] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD USA. RP Palacios, GF (reprint author), US Army Med Res Inst Infect Dis, Ctr Genome Sci Div, Frederick, MD 21702 USA. EM gustavo.f.palacios.ctr@us.army.mil RI Palacios, Gustavo/I-7773-2015; OI Palacios, Gustavo/0000-0001-5062-1938; Kuhn, Jens H./0000-0002-7800-6045 FU Defense Threat Reduction Agency; NIAID [HHSN272200700016I]; National Science Foundation Graduate research fellowship [DGE 1144152] FX This work was supported by Defense Threat Reduction Agency. J.H.K. performed this work as an employee of Tunnell Government Services, Inc., a subcontractor to Battelle Memorial Institute under its prime contract with NIAID, under contract no. HHSN272200700016I. This material is based upon work supported by the National Science Foundation Graduate research fellowship under grant no. DGE 1144152. NR 24 TC 22 Z9 23 U1 1 U2 15 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 2150-7511 J9 MBIO JI mBio PD JAN-FEB PY 2015 VL 6 IS 1 AR e02227-14 DI 10.1128/mBio.02227-14 PG 4 WC Microbiology SC Microbiology GA CC8PZ UT WOS:000350631900039 ER PT J AU Warren, TK Whitehouse, CA Wells, J Welch, L Heald, AE Charleston, JS Sazani, P Reid, SP Iversen, PL Bavari, S AF Warren, Travis K. Whitehouse, Chris A. Wells, Jay Welch, Lisa Heald, Alison E. Charleston, Jay S. Sazani, Pete Reid, St Patrick Iversen, Patrick L. Bavari, Sina TI A Single Phosphorodiamidate Morpholino Oligomer Targeting VP24 Protects Rhesus Monkeys against Lethal Ebola Virus Infection SO MBIO LA English DT Article ID STAT1 AB Ebola viruses (EBOV) cause severe disease in humans and nonhuman primates with high mortality rates and continue to emerge in new geographic locations, including several countries in West Africa, the site of a large ongoing outbreak. Phosphorodiamidate morpholino oligomers (PMOs) are synthetic antisense molecules that are able to target mRNAs in a sequence-specific fashion and suppress translation through steric hindrance. We previously showed that the use of PMOs targeting a combination of VP35 and VP24 protected rhesus monkeys from lethal EBOV infection. Surprisingly, the present study revealed that a PMOplus compound targeting VP24 alone was sufficient to confer protection from lethal EBOV infection but that a PMOplus targeting VP35 alone resulted in no protection. This study further substantiates recent data demonstrating that VP24 may be a key virulence factor encoded by EBOV and suggests that VP24 is a promising target for the development of effective anti-EBOV countermeasures. IMPORTANCE Several West African countries are currently being ravaged by an outbreak of Ebola virus (EBOV) that has become a major epidemic affecting not only these African countries but also Europe and the United States. A better understanding of the mechanism of virulence of EBOV is important for the development of effective treatments, as no licensed treatments or vaccines for EBOV disease are currently available. This study of phosphorodiamidate morpholino oligomers (PMOs) targeting the mRNAs of two different EBOV proteins, alone and in combination, demonstrated that targeting a single protein was effective at conferring a significant survival benefit in an EBOV lethal primate model. Future development of PMOs with efficacy against EBOV will be simplified if only one PMO is required instead of a combination, particularly in terms of regulatory approval. C1 [Warren, Travis K.; Whitehouse, Chris A.; Wells, Jay; Welch, Lisa; Reid, St Patrick; Bavari, Sina] US Army Med Res Inst Infect Dis, Mol & Translat Sci Div, Ft Detrick, MD 21702 USA. [Heald, Alison E.; Charleston, Jay S.; Sazani, Pete; Iversen, Patrick L.] Sarepta Therapeut Inc, Cambridge, MA USA. [Heald, Alison E.] Univ Washington, Seattle, WA 98195 USA. [Iversen, Patrick L.] Oregon State Univ, Corvallis, OR 97331 USA. RP Bavari, S (reprint author), US Army Med Res Inst Infect Dis, Mol & Translat Sci Div, Ft Detrick, MD 21702 USA. EM sina.bavari.civ@mail.mil FU Joint Product Management Office of BioDefense Therapeutics (BD-Tx) [W9113M-10-C-0056] FX This work was conducted under a contract (W9113M-10-C-0056) with the Joint Product Management Office of BioDefense Therapeutics (BD-Tx). BD-Tx is a component of the Medical Countermeasure Systems Joint Project Management Office (JPM-MCS) within the U.S. Department of Defense's Joint Program Executive Office for Chemical and Biological Defense. NR 16 TC 17 Z9 17 U1 2 U2 9 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 2150-7511 J9 MBIO JI mBio PD JAN-FEB PY 2015 VL 6 IS 1 AR e02344-14 DI 10.1128/mBio.02344-14 PG 4 WC Microbiology SC Microbiology GA CC8PZ UT WOS:000350631900003 ER PT J AU Thakur, GS Daigle, BJ Dean, KR Zhang, YY Rodriguez-Fernandez, M Hammamieh, R Yang, R Jett, M Palma, J Petzold, LR Doyle, FJ AF Thakur, Gunjan S. Daigle, Bernie J., Jr. Dean, Kelsey R. Zhang, Yuanyang Rodriguez-Fernandez, Maria Hammamieh, Rasha Yang, Ruoting Jett, Marti Palma, Joseph Petzold, Linda R. Doyle, Francis J., III TI Systems biology approach to understanding post-traumatic stress disorder SO MOLECULAR BIOSYSTEMS LA English DT Review ID ANTERIOR CINGULATE CORTEX; MEDIAL PREFRONTAL CORTEX; BREAST-CANCER METASTASIS; GENE NETWORK INFERENCE; DNA METHYLATION; HIPPOCAMPAL VOLUME; BIOMARKER IDENTIFICATION; MICROARRAY EXPERIMENTS; EXPRESSION PROFILES; PERIPHERAL-BLOOD AB Post-traumatic stress disorder (PTSD) is a psychological disorder affecting individuals that have experienced life-changing traumatic events. The symptoms of PTSD experienced by these subjects-including acute anxiety, flashbacks, and hyper-arousal-disrupt their normal functioning. Although PTSD is still categorized as a psychological disorder, recent years have witnessed a multi-directional research effort attempting to understand the biomolecular origins of the disorder. This review begins by providing a brief overview of the known biological underpinnings of the disorder resulting from studies using structural and functional neuroimaging, endocrinology, and genetic and epigenetic assays. Next, we discuss the systems biology approach, which is often used to gain mechanistic insights from the wealth of available high-throughput experimental data. Finally, we provide an overview of the current computational tools used to decipher the heterogeneous types of molecular data collected in the study of PTSD. C1 [Thakur, Gunjan S.; Daigle, Bernie J., Jr.; Dean, Kelsey R.; Rodriguez-Fernandez, Maria; Palma, Joseph; Doyle, Francis J., III] Univ Calif Santa Barbara, Inst Collaborat Biotechnol, Santa Barbara, CA 93106 USA. [Thakur, Gunjan S.; Dean, Kelsey R.; Rodriguez-Fernandez, Maria; Petzold, Linda R.; Doyle, Francis J., III] Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USA. [Zhang, Yuanyang] Univ Calif Santa Barbara, Dept Comp Sci, Santa Barbara, CA 93106 USA. [Hammamieh, Rasha; Yang, Ruoting; Jett, Marti; Palma, Joseph] US Army, Ctr Environm Hlth Res, Ft Detrick, MD USA. [Petzold, Linda R.] Univ Calif Santa Barbara, Dept Mech Engn, Santa Barbara, CA 93106 USA. RP Doyle, FJ (reprint author), Univ Calif Santa Barbara, Inst Collaborat Biotechnol, Santa Barbara, CA 93106 USA. EM doyle@engineering.ucsb.edu RI Rodriguez-Fernandez, Maria/I-7193-2016; Zhang, Yuanyang/S-8815-2016 OI Rodriguez-Fernandez, Maria/0000-0003-1966-2920; Zhang, Yuanyang/0000-0002-5901-4242 FU institute for Collaborative Biotechnologies through grant from the US Army research office [W911NF-10-2-0111]; USAMRMC [09284002] FX This work was supported in part by the institute for Collaborative Biotechnologies through grant from the US Army research office (W911NF-10-2-0111) and the grant from USAMRMC (09284002). NR 150 TC 2 Z9 2 U1 17 U2 38 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1742-206X EI 1742-2051 J9 MOL BIOSYST JI Mol. Biosyst. PY 2015 VL 11 IS 4 BP 980 EP 993 DI 10.1039/c4mb00404c PG 14 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA CE0KQ UT WOS:000351493300001 PM 25627823 ER PT J AU Gosch, NJC Miller, ML Gemeinhardt, TR Sampson, SJ Bonneau, JL AF Gosch, Nathan J. C. Miller, Marcus L. Gemeinhardt, Todd R. Sampson, Schuyler J. Bonneau, Joseph L. TI Age-0 Sturgeon Accessibility to Constructed and Modified Chutes in the Lower Missouri River SO NORTH AMERICAN JOURNAL OF FISHERIES MANAGEMENT LA English DT Article ID PALLID STURGEON; SHOVELNOSE STURGEON; LARVAE AB Shallow-water habitat is hypothesized to provide nursery habitat for young fish. The construction of side-channel chutes to restore shallow-water habitat is common in the lower Missouri River; however, a recent adaptive management strategy document (developed by a multiagency, multidiscipline team), as well as previous research, has suggested that the accessibility of chutes to age-0 Scaphirhynchus spp. (sturgeon hereafter) may be limited. Access is a critical prerequisite for young fish utilizing chute habitat; thus, we investigated chute-specific accessibility for age-0 sturgeon at seven chutes (constructed and natural). Age-0 sturgeon were capable of accessing most chutes; however, accessibility appeared limited at sites with highly restrictive inlet structures. Our results suggest that future consideration of chute inlet designs that meet authorized Missouri River purposes while providing improved fish access is warranted. Additionally, capture sites for exogenously feeding age-0 sturgeon were usually deeper (> 1.5 m) and faster (> 0.5 m/s) than sites without sturgeon in chute and adjacent main-stem habitats. This finding is consistent with previous research that suggests that slow and shallow habitats may not be used by age-0 sturgeon as frequently as other habitat types in the lower Missouri River. C1 [Gosch, Nathan J. C.; Miller, Marcus L.; Gemeinhardt, Todd R.] US Army Corps Engineers, Environm Resources Sect, Kansas City, MO 64106 USA. [Sampson, Schuyler J.] Nebraska Game & Pk Commiss, Lincoln, NE 68503 USA. [Bonneau, Joseph L.] US Army Corps Engineers, Threatened & Endangered Species Sect, Yankton, SD 57078 USA. RP Gosch, NJC (reprint author), US Army Corps Engineers, Environm Resources Sect, 601 East 12th St, Kansas City, MO 64106 USA. EM nathan.j.gosch@usace.army.mil FU U.S. Army Corps of Engineers Kansas City District FX We thank Anthony Civiello, Kevin Montemayor, Jerrod Hall, and Ken Hatten, as well as numerous other U.S. Army Corps of Engineers and Nebraska Game and Parks Commission staff for field assistance. Michael Chapman, Daniel Pridal, Tim Welker, and Heather Hill provided valuable comments on an earlier draft of this manuscript. This study was funded by the U.S. Army Corps of Engineers Kansas City District. The contents of this report are not to be used for advertising, publication, or promotional purposes. Reference to trade names does not imply endorsement by the U.S. Government. All product names and trademarks cited are the property of their respective owners. The findings of this report are not to be construed as an official Department of Army position unless so designated by other authorized documents. NR 25 TC 4 Z9 4 U1 1 U2 6 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0275-5947 EI 1548-8675 J9 N AM J FISH MANAGE JI North Am. J. Fish Manage. PY 2015 VL 35 IS 1 BP 75 EP 85 DI 10.1080/02755947.2014.975300 PG 11 WC Fisheries SC Fisheries GA CD9VN UT WOS:000351447600007 ER PT B AU Baird, S AF Baird, Shannon BE Schinke, RJ McGannon, KR TI BE, KNOW, DO model of consulting An exploration of how experiences with soldiers affected me and how my notions of self affected soldiers' experiences SO PSYCHOLOGY OF SUB-CULTURE IN SPORT AND PHYSICAL ACTIVITY: CRITICAL PERSPECTIVES SE International Perspectives on Key Issues in Sport and Exercise Psychology LA English DT Article; Book Chapter ID PSYCHOLOGY SERVICE DELIVERY; APPLIED SPORT PSYCHOLOGY; REFLECTIVE PRACTICE; EXERCISE PSYCHOLOGY C1 US Army, Washington, DC 20310 USA. RP Baird, S (reprint author), US Army, Washington, DC 20310 USA. NR 36 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE PI ABINGDON PA 2 PARK SQ, MILTON PARK, ABINGDON OX14 4RN, OXFORD, ENGLAND BN 978-1-84872-158-6; 978-1-315-77849-5; 978-1-84872-157-9 J9 INT PER KEY ISS SPO PY 2015 BP 135 EP 152 PG 18 WC Hospitality, Leisure, Sport & Tourism; Psychology, Multidisciplinary SC Social Sciences - Other Topics; Psychology GA BC1HX UT WOS:000350119300011 ER PT J AU Giri, L Mallick, G Jackson, AC Griep, MH Karna, SP AF Giri, L. Mallick, G. Jackson, A. C. Griep, M. H. Karna, S. P. TI Synthesis and characterization of high-purity, single phase hexagonal Bi2Te3 nanostructures SO RSC ADVANCES LA English DT Article ID BISMUTH TELLURIDE; THERMOELECTRIC-MATERIALS; TOPOLOGICAL INSULATORS; RAMAN-SPECTROSCOPY; NANOPARTICLES; MORPHOLOGY; NANOSHEETS; THICKNESS; FILMS AB In order to synthesize defect free, highly crystalline single phase nanostructured bismuth chalcogenides, we have investigated the effects of several reaction conditions including, solvents, temperatures, reaction time, and reducing agents. A small variation in the reaction method resulted in Bi2Te3 with different morphologies, ranging from nanosize particles, rods, platelets, and tubes to nanosheets. The materials were characterized by powder X-ray crystallography, scanning electron microscopy, transmission electron microscopy, energy dispersive X-ray analysis, Raman spectroscopy, and four-probe current (I)voltage (V) analysis. An optimized reaction condition allowed the synthesis of single-phase, impurity-free hexagonal nanoplates with size varying between 50 nm and 500 nm and thickness varying between 45 nm and 55 nm in a reproducible manner. The Raman spectra of the optimized hexagonal plates and sheets showed infra red (IR)-active modes around 118 cm(-1) resulting from symmetry breaking, a characteristic feature of nanostructured Bi2Te3. Additional peaks at 94 cm(-1) in the nanosheets, resulting from the surface phonon mode further confirmed the ultrathin Bi2Te3 structures. The I-V measurements on the optimized surface showed an n-type semiconducting behavior. The surface current measured as a function of applied voltage is two orders of magnitude higher than that across the stacked pellet in ambient conditions and much higher compared to previously published data on few quintuplet-thick Bi2Te3 nanofilms. The highlights of this study are the optimal solvothermic reaction conditions and their impact on obtaining defect free, highly crystalline single phase bismuth chalcogenides. C1 [Giri, L.; Mallick, G.; Griep, M. H.; Karna, S. P.] US Army Res Lab, WMRD, Aberdeen Proving Ground, MD 21005 USA. [Jackson, A. C.] Axalta Coating Syst, Wilmington, DE 19803 USA. RP Karna, SP (reprint author), US Army Res Lab, WMRD, Aberdeen Proving Ground, MD 21005 USA. EM shashi.p.karna.civ@mail.mil FU U.S. Army Research Laboratory (US ARL) FX This research by one of us (L. G.) was supported in part by an appointment to the Research Participation Program at the U.S. Army Research Laboratory (US ARL) administered by the Oak Ridge Institute for Science and Education through an inter agency agreement between the U.S. Department of Energy and US ARL. Fruitful discussions with Kate Duncan are gratefully acknowledged. NR 36 TC 2 Z9 2 U1 7 U2 36 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2046-2069 J9 RSC ADV JI RSC Adv. PY 2015 VL 5 IS 32 BP 24930 EP 24935 DI 10.1039/c5ra02303c PG 6 WC Chemistry, Multidisciplinary SC Chemistry GA CD8OE UT WOS:000351354000016 ER PT J AU Crouse, LCB Lent, EM Leach, GJ AF Crouse, Lee C. B. Lent, Emily May Leach, Glenn J. TI Oral Toxicity of 3-Nitro-1,2,4-triazol-5-one in Rats SO INTERNATIONAL JOURNAL OF TOXICOLOGY LA English DT Article DE 3-nitro-1; 2; 4-triazole-5-one; NTO; oral toxicity; FOB; testicular toxicity; benchmark dose; rat ID SUBCHRONIC TOXICITY; FISCHER-344 RATS; C-14-LABELED 5-NITRO-1,2,4-TRIAZOL-3-ONE; TESTICULAR TOXICITY; TRIAZOLE FUNGICIDE; LIVER MICROSOMES; METABOLISM; 1,3,5-TRINITROBENZENE; TEBUCONAZOLE; EXPOSURE AB 3-Nitro-1,2,4-triazol-5-one (NTO), an insensitive explosive, was evaluated to assess potential environmental and human health effects. A 14-day oral toxicity study in Sprague-Dawley rats was conducted with NTO in polyethylene glycol -200 by gavage at doses of 0, 250, 500, 1000, 1500, or 2000 mg/kg-d. Body mass and food consumption decreased in males (2000 mg/kg-d), and testes mass was reduced at doses of 500 mg/kg-d and greater. Based on the findings in the 14-day study, a 90-day study was conducted at doses of 0, 30, 100, 315, or 1000 mg/kg-d NTO. There was no effect on food consumption, body mass, or neurobehavioral parameters. Males in the 315 and 1000 mg/kg-d groups had reduced testes mass with associated tubular degeneration and atrophy. The testicular effects were the most sensitive adverse effect and were used to derive a benchmark dose (BMD) of 70 mg/kg-d with a 10% effect level (BMDL10) of 40 mg/kg-d. C1 [Crouse, Lee C. B.; Lent, Emily May; Leach, Glenn J.] US Army Publ Hlth Command, Army Inst Publ Hlth, Aberdeen Proving Ground, MD 21010 USA. RP Crouse, LCB (reprint author), US Army Publ Hlth Command, Army Inst Publ Hlth, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM lee.crouse.civ@mail.mil FU U.S. Army Armament Research, Development, and Engineering Center (MIPR) [MIPR8FGM009485] FX The author(s) disclose receipt of the following financial support for the research, authorship, and/or publication of this article: funded by the U.S. Army Armament Research, Development, and Engineering Center (MIPR number MIPR8FGM009485, 2008). NR 39 TC 6 Z9 6 U1 1 U2 15 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1091-5818 EI 1092-874X J9 INT J TOXICOL JI Int. J. Toxicol. PD JAN-FEB PY 2015 VL 34 IS 1 BP 55 EP 66 DI 10.1177/1091581814567177 PG 12 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA CB9WZ UT WOS:000349986200008 PM 25589095 ER PT J AU Ridderhoff, KJ Hull, JR Sandberg, SK AF Ridderhoff, Kevin J. Hull, Jessica R. Sandberg, Sheila K. TI Blanchfield Army Community Hospital Polypharmacy Clinic SO JOURNAL OF MANAGED CARE PHARMACY LA English DT Editorial Material AB The increased use of central nervous system depressants (CNSD) and psychotropics are one of the many factors that contribute to suicidal behavior in soldiers. U.S. Army policy requires medication screening for any soldier prescribed 4 or more medications when at least 1 of the medications is a CNSD or psychotropic. Constant deployments challenged health care provider ability to comply with required screenings, and senior leaders sought proactive intervention to reduce medication risks upon return of the 101st Airborne Division (Air Assault) from deployment in 2011. A pharmacy-led team established the Polypharmacy Clinic (PC) at Blanchfield Army Community Hospital. Of the 3,999 soldiers assigned, 540 (13.5%) met the initial screening criteria. Success of the pilot program led to the mandatory screening of all other Fort Campbell, Kentucky, brigades. During the first 12 months, 895 soldiers were seen by a clinical pharmacist, and 1,574 interventions were documented. Significant interventions included medication added (121), medication changed (258), medication stopped (164), lab monitoring recommended (172), adverse reaction mitigated (41), therapeutic duplication prevented (61), and drug-drug interaction identified (93). Additionally, 55 soldiers were recommended for temporary duty profiles based on their adverse drug effects. Ten soldiers were recommended for enhanced controlled substance monitoring. Placing soldiers on clinically appropriate medications and removing potentially harmful medications from their possession are examples of how the PC positively impacted the Commanding General's ability to deploy a fully medically ready force. Soldiers consistently remarked favorably on the thorough medication counseling provided at their PC appointments. Innovative notes within the electronic health record summarized relevant findings regarding soldiers' medications, which allowed providers to quickly pinpoint and adjust medication regimens. With each identified high-risk soldier, we decreased the potential for postdeployment medication issues. Additionally, the PC generated over $70,000 in relative value units for the hospital. Copyright (C) 2015, Academy of Managed Care Pharmacy. All rights reserved. C1 [Ridderhoff, Kevin J.] Def Hlth Agcy, Pharm Operat Div, Formulary Management Branch, Falls Church, VA 22042 USA. [Hull, Jessica R.] Womack Army Med Ctr, Clin Pharm, Ft Bragg, NC USA. RP Ridderhoff, KJ (reprint author), Def Hlth Agcy, Pharm Operat Div, 7700 Arlington Blvd,Ste 501, Falls Church, VA 22042 USA. EM kevin.ridderhoff@dha.mil NR 7 TC 0 Z9 0 U1 1 U2 1 PU ACAD MANAGED CARE PHARMACY PI ALEXANDRIA PA 100 N PITT ST, 400, ALEXANDRIA, VA 22314-3134 USA SN 1083-4087 J9 J MANAGE CARE PHARM JI J. Manag. Care Pharm. PD JAN PY 2015 VL 21 IS 1 BP 8 EP 11 PG 4 WC Health Care Sciences & Services; Pharmacology & Pharmacy SC Health Care Sciences & Services; Pharmacology & Pharmacy GA CC8KP UT WOS:000350617900001 PM 25562768 ER PT J AU Scheuermann, E Costello, M Silton, S Sahu, J AF Scheuermann, Edward Costello, Mark Silton, Sidra Sahu, Jubaraj TI Aerodynamic Characterization of a Microspoiler System for Supersonic Finned Projectiles SO JOURNAL OF SPACECRAFT AND ROCKETS LA English DT Article ID PREDICTION AB To create highly maneuverable projectiles, some physical control mechanism is needed that is capable of altering the projectile trajectory in a desired manner. The work reported here considers a small flow control device, termed a microspoiler system, located between the rear stabilizing fins of a projectile. Such a mechanism relies on the boundary-layer shock interaction between the projectile body, rear stabilizing fins, and microspoilers to provide a multiplicative effect on controllable forces and moments. To investigate performance of the microspoiler control mechanism, projectile trajectories with microspoilers were generated both computationally using a coupled CFD and rigid-body dynamic simulation and experimentally from spark range testing. Using this computational and experimental trajectory information, aerodynamic coefficients both with and without microspoilers were estimated and found to be in good agreement where the major effect of the microspoiler system is the addition of trim forces and moments along with a slight increase in axial forces. Additionally, control authority of a basic finned projectile equipped with an active microspoiler system is investigated for a typical direct-fire shooting scenario. C1 [Scheuermann, Edward] Georgia Inst Technol, Woodruff Sch Mech Engn, Atlanta, GA 30332 USA. [Costello, Mark] Georgia Inst Technol, Woodruff Sch Mech Engn, Guggenheim Sch Aerosp Engn, Atlanta, GA 30332 USA. [Silton, Sidra; Sahu, Jubaraj] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen, MD 21005 USA. RP Scheuermann, E (reprint author), Georgia Inst Technol, Woodruff Sch Mech Engn, Atlanta, GA 30332 USA. NR 13 TC 2 Z9 2 U1 3 U2 6 PU AMER INST AERONAUTICS ASTRONAUTICS PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0022-4650 EI 1533-6794 J9 J SPACECRAFT ROCKETS JI J. Spacecr. Rockets PD JAN-FEB PY 2015 VL 52 IS 1 BP 253 EP 263 DI 10.2514/1.A33005 PG 11 WC Engineering, Aerospace SC Engineering GA CD2CP UT WOS:000350881800023 ER PT J AU Fleischmann, C Gopez, J Lundberg, P Ritter, H Killops, KL Hawker, CJ Klinger, D AF Fleischmann, Carolin Gopez, Jeffrey Lundberg, Pontus Ritter, Helmut Killops, Kato L. Hawker, Craig J. Klinger, Daniel TI A robust platform for functional microgels via thiol-ene chemistry with reactive polyether-based nanoparticles SO POLYMER CHEMISTRY LA English DT Article ID DRUG-DELIVERY APPLICATIONS; LIGHT-INDUCED DEGRADATION; STIMULI-RESPONSIVE MICROGELS; CLICK CHEMISTRY; MINIEMULSION POLYMERIZATION; THERMORESPONSIVE MICROGELS; SWELLING RESPONSE; IONIC MICROGELS; ACID) MICROGELS; CROSS-LINKERS AB We herein report the development of crosslinked polyether particles as a reactive platform for the preparation of functional microgels. Thiol-ene crosslinking of poly(allyl glycidyl ether) in miniemulsion droplets -stabilized by a surface active, bio-compatible polyethylene glycol block copolymer -resulted in colloidal gels with a PEG corona and an inner polymeric network containing reactive allyl units. The stability of the allyl groups allows the microgels to be purified and stored before a second, subsequent thiol-ene functionalization step allows a wide variety of pH-and chemically-responsive groups to be introduced into the nanoparticles. The facile nature of this synthetic platform enables the preparation of microgel libraries that are responsive to different triggers but are characterized by the same size distribution, surface functionality, and crosslinking density. In addition, the utilization of a crosslinker containing cleavable ester groups renders the resulting hydrogel particles degradable at elevated pH or in the presence of esterase under physiological conditions. C1 [Fleischmann, Carolin; Ritter, Helmut] Univ Dusseldorf, Inst Organ Chem & Makromol Chem, D-40225 Dusseldorf, Germany. [Fleischmann, Carolin; Gopez, Jeffrey; Lundberg, Pontus; Hawker, Craig J.; Klinger, Daniel] Dept Chem & Biochem, Mat Res Lab, Santa Barbara, CA 93106 USA. [Fleischmann, Carolin; Gopez, Jeffrey; Lundberg, Pontus; Hawker, Craig J.; Klinger, Daniel] Dept Mat, Santa Barbara, CA 93106 USA. [Killops, Kato L.] US Army Res Dev & Engn Command, Edgewood Chem Biol Ctr, Proving Ground, MD 21010 USA. RP Hawker, CJ (reprint author), Dept Chem & Biochem, Mat Res Lab, Santa Barbara, CA 93106 USA. EM hawker@mrl.ucsb.edu; klinger@mrl.ucsb.edu FU U.S. Army Research Office [W911NF-09-0001]; U.S. Army Basic Research Program and Edgewood Chemical Biological Center; National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services [HHSN268201000046C]; Wenner-Gren foundations; Bengt Lundqvist memorial foundation; MRSEC Program of the National Science Foundation [DMR 1121053] FX This work was supported by the Institute for Collaborative Biotechnologies through grant W911NF-09-0001 from the U.S. Army Research Office (D. K. and C. J. H.), the U.S. Army Basic Research Program and Edgewood Chemical Biological Center (K.L.K.), and the National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, under Contract no. HHSN268201000046C (D. K., and C. J. H.). The content of the information does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred. P. L. would like to thank the Wenner-Gren foundations and Bengt Lundqvist memorial foundation for financial support. Characterization work was enabled by MRL Central Facilities supported by the MRSEC Program of the National Science Foundation under Award no. DMR 1121053 (C. F., J. G. and P. L.). NR 66 TC 4 Z9 4 U1 10 U2 70 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1759-9954 EI 1759-9962 J9 POLYM CHEM-UK JI Polym. Chem. PY 2015 VL 6 IS 11 BP 2029 EP 2037 DI 10.1039/c4py01766h PG 9 WC Polymer Science SC Polymer Science GA CC8TY UT WOS:000350642400016 PM 26005499 ER PT J AU Reiter, MJ Schwope, RB Kini, JA York, GE Suhr, AW AF Reiter, Michael J. Schwope, Ryan B. Kini, Jonathan A. York, Gerald E. Suhr, Abraham W. TI Postoperative Imaging of the Orbital Contents SO RADIOGRAPHICS LA English DT Article ID GLAUCOMA DRAINAGE IMPLANTS; INTRAOCULAR-LENS IMPLANTS; COMPUTED-TOMOGRAPHY; EYELID WEIGHTS; UNITED-STATES; SILICONE OIL; MR; CT; APPEARANCE; DEVICES AB Ophthalmologists perform a wide array of interventions on the orbital contents. The surgical treatment of glaucoma, cataracts, retinal detachment, and ocular trauma or malignancy results in alteration of the standard anatomy, which is often readily evident at radiologic examinations. The ability to accurately recognize the various imaging manifestations after orbital surgery is critical for radiologists to avoid misdiagnosis. Of particular importance is familiarity with the numerous types of implanted devices, such as glaucoma drainage devices, orbital implants, and eyelid weights. Although knowledge of patients' surgical history is helpful, this information is often not available at the time of interpretation. Fortunately, there are characteristic posttreatment findings that enable diagnosis. The imaging features of the most commonly performed ophthalmologic procedures are highlighted, with emphasis on computed tomography and magnetic resonance ( MR) imaging, because they are currently the primary modalities involved in evaluating the orbits. Glaucoma drainage devices and orbital implants after enucleation are two of the more pertinent implanted devices because their composition has substantially evolved over the past 2 decades, which affects their imaging appearance. Some devices, such as the Baerveldt Glaucoma Implant and platinum-weighted eyelid implants, may distort radiologic images. The MR imaging safety profiles of numerous implanted devices are also reported. (C) RSNA, 2015 . radiographics. rsna. org C1 [Reiter, Michael J.; Schwope, Ryan B.; Kini, Jonathan A.; York, Gerald E.] Brooke Army Med Ctr, Dept Radiol, San Antonio, TX 78234 USA. [Suhr, Abraham W.] Brooke Army Med Ctr, Dept Ophthalmol, San Antonio, TX 78234 USA. RP Reiter, MJ (reprint author), Brooke Army Med Ctr, Dept Radiol, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA. EM mikereiter13@yahoo.com NR 45 TC 1 Z9 1 U1 0 U2 3 PU RADIOLOGICAL SOC NORTH AMERICA PI OAK BROOK PA 820 JORIE BLVD, OAK BROOK, IL 60523 USA SN 0271-5333 J9 RADIOGRAPHICS JI Radiographics PD JAN-FEB PY 2015 VL 35 IS 1 BP 221 EP 234 DI 10.1148/rg.351140008 PG 14 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA CD0FF UT WOS:000350745300016 PM 25590399 ER PT J AU Wildman, RA Gazonas, GA AF Wildman, Raymond A. Gazonas, George A. TI Multiobjective topology optimization of energy absorbing materials SO STRUCTURAL AND MULTIDISCIPLINARY OPTIMIZATION LA English DT Article DE Topology optimization; Pareto optimization; Genetic programming; Energy absorbing material ID CONSTRUCTIVE SOLID GEOMETRY; COUPLED MULTISCALE MODEL; HYBRID CELLULAR-AUTOMATA; GENETIC ALGORITHM; NUMERICAL SIMULATIONS; INVERSE SCATTERING; CRACK-GROWTH; LEVEL SET; DESIGN; MICROSTRUCTURES AB A method for the multiobjective optimization of local-scale material topology is presented. The topology optimization scheme is based on a constructive solid geometry-like representation, in which convex polygons-defined as the convex hull of arbitrary-length lists of points-are combined using an overlapping function. This data structure is tree-shaped and so genetic programming is used as the optimizer. The forward problem is solved with a multiscale finite element method with automatic cohesive zone insertion to model damage. As a multiscale method, loads and boundary conditions are applied and objective functions measured at a global scale, while the local scale material structure is optimized. The global scale geometry is assumed fixed. Pareto optimal designs are generated, representing optimal tradeoffs between conflicting goals: quasi-static displacement and dynamic strain energy. Results demonstrate the efficacy of the proposed algorithm. C1 [Wildman, Raymond A.; Gazonas, George A.] US Army Res Lab, Attn RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA. RP Wildman, RA (reprint author), US Army Res Lab, Attn RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA. EM raymond.a.wildman.civ@mail.mil OI Gazonas, George/0000-0002-2715-016X FU Department of Defense High Performance Computing Modernization Program (HPCMP) Challenge Project [ARLAP02331C5V] FX This research was supported by grants of computer time and resources on HPC systems under the Department of Defense High Performance Computing Modernization Program (HPCMP) Challenge Project ARLAP02331C5V. NR 50 TC 1 Z9 1 U1 10 U2 25 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1615-147X EI 1615-1488 J9 STRUCT MULTIDISCIP O JI Struct. Multidiscip. Optim. PD JAN PY 2015 VL 51 IS 1 BP 125 EP 143 DI 10.1007/s00158-014-1117-8 PG 19 WC Computer Science, Interdisciplinary Applications; Engineering, Multidisciplinary; Mechanics SC Computer Science; Engineering; Mechanics GA CD2HM UT WOS:000350896500008 ER PT S AU Akers, KS Cardile, AP Wenke, JC Murray, CK AF Akers, Kevin S. Cardile, Anthony P. Wenke, Joseph C. Murray, Clinton K. BE Donelli, G TI Biofilm Formation by Clinical Isolates and Its Relevance to Clinical Infections SO BIOFILM-BASED HEALTHCARE-ASSOCIATED INFECTIONS, VOL I SE Advances in Experimental Medicine and Biology LA English DT Article; Book Chapter ID CANDIDA-PARAPSILOSIS COMPLEX; MYCOBACTERIUM-AVIUM COMPLEX; STAPHYLOCOCCUS-AUREUS BIOFILM; FIBRONECTIN-BINDING PROTEINS; CYSTIC-FIBROSIS PATIENTS; ENTEROAGGREGATIVE ESCHERICHIA-COLI; TOTAL KNEE ARTHROPLASTY; PSEUDOMONAS-AERUGINOSA; IN-VITRO; CHRONIC RHINOSINUSITIS AB Reports of biofilms have increased exponentially in the scientific literature over the past two decades, yet the vast majority of these are basic science investigations with limited clinical relevance. Biofilm studies involving clinical isolates are most often surveys of isolate collections, but suffer from lack of standardization in methodologies for producing and assessing biofilms. In contrast, more informative clinical studies correlating biofilm formation to patient data have infrequently been reported. In this chapter, biofilm surveys of clinical isolates of aerobic and anaerobic bacteria, mycobacteria, and Candida are reviewed, as well as those pertaining to the unique situation of cystic fibrosis. In addition, the influence of host components on in vitro biofilm formation, as well as published studies documenting the clinical impact of biofilms in human infections, are presented. C1 [Akers, Kevin S.; Wenke, Joseph C.] US Army Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, Houston, TX 78234 USA. [Akers, Kevin S.; Cardile, Anthony P.; Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis Serv, Houston, TX USA. RP Akers, KS (reprint author), US Army Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, Houston, TX 78234 USA. EM kevin.s.akers.mil@mail.mil NR 175 TC 6 Z9 6 U1 1 U2 17 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0065-2598 BN 978-3-319-11038-7; 978-3-319-11037-0 J9 ADV EXP MED BIOL JI Adv.Exp.Med.Biol. PY 2015 VL 830 BP 1 EP 28 DI 10.1007/978-3-319-11038-7_1 D2 10.1007/978-3-319-11038-7 PG 28 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA BC1SD UT WOS:000350409600002 PM 25366218 ER PT J AU Choi, Y AF Choi, Yong TI Comment on: A case-matched study of the differences in bone mineral density 1 year after 3 different bariatric procedures SO SURGERY FOR OBESITY AND RELATED DISEASES LA English DT Editorial Material ID SLEEVE GASTRECTOMY; GASTRIC BYPASS; SURGERY C1 Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA. RP Choi, Y (reprint author), Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1550-7289 EI 1878-7533 J9 SURG OBES RELAT DIS JI Surg. Obes. Relat. Dis. PD JAN-FEB PY 2015 VL 11 IS 1 BP 186 EP 186 PG 1 WC Surgery SC Surgery GA CC7FY UT WOS:000350534300030 PM 25547058 ER PT J AU Bell, KR Brockway, JA Fann, JR Cole, WR De Lore, JS Bush, N Lang, AJ Hart, T Warren, M Dikmen, S Temkin, N Jain, S Raman, R Stein, MB AF Bell, Kathleen R. Brockway, Jo Ann Fann, Jesse R. Cole, Wesley R. De Lore, Jef St. Bush, Nigel Lang, Ariel J. Hart, Tessa Warren, Michael Dikmen, Sureyya Temkin, Nancy Jain, Sonia Raman, Rema Stein, Murray B. TI Concussion treatment after combat trauma: Development of a telephone based, problem solving intervention for service members SO CONTEMPORARY CLINICAL TRIALS LA English DT Article DE Concussion; Brain Injury; Military; Problem solving training; Telephone intervention; Telehealth ID POSTTRAUMATIC-STRESS-DISORDER; RANDOMIZED CONTROLLED-TRIAL; COGNITIVE-BEHAVIORAL THERAPY; IDENTIFICATION TEST AUDIT; BRAIN-INJURY; MENTAL-HEALTH; PRIMARY-CARE; PSYCHOLOGICAL TREATMENT; 1ST YEAR; DEPRESSION AB Military service members (SMs) and veterans who sustain mild traumatic brain injuries (mTBI) during combat deployments often have co-morbid conditions but are reluctant to seek out therapy in medical or mental health settings. Efficacious methods of intervention that are patient-centered and adaptable to a mobile and often difficult-to-reach population would be useful in improving quality of life. This article describes a new protocol developed as part of a randomized clinical trial of a telephone-mediated program for SMs with mTBI. The 12-session program combines problem solving training (PST) with embedded modules targeting depression, anxiety, insomnia, and headache. The rationale and development of this behavioral intervention for implementation with persons with multiple co-morbidities is described along with the proposed analysis of results. In particular, we provide details regarding the creation of a treatment that is manualized yet flexible enough to address a wide variety of problems and symptoms within a standard framework. The methods involved in enrolling and retaining an often hard-to-study population are also highlighted. (C) 2014 Elsevier Inc. All rights reserved. C1 [Bell, Kathleen R.; Brockway, Jo Ann; Dikmen, Sureyya; Temkin, Nancy] Univ Washington, Dept Rehabil Med, Seattle, WA 98195 USA. [Fann, Jesse R.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. [Cole, Wesley R.] WAMC, Dept Brain Injury Med, Def & Vet Brain Injury Ctr, Ft Bragg, NC 28310 USA. [De Lore, Jef St.; Dikmen, Sureyya; Temkin, Nancy] Univ Washington, Dept Neurol Surg, Seattle, WA 98104 USA. [Bush, Nigel] Natl Ctr Telehlth & Technol, Tacoma, WA 98431 USA. [Lang, Ariel J.; Stein, Murray B.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA. [Hart, Tessa] Moss Rehabil Res Inst, Elkins Pk, PA 19027 USA. [Warren, Michael] Fielding Behav Hlth, Clin Psychol Doctoral Intern, Kirkland, WA 98034 USA. [Temkin, Nancy] Univ Washington, Dept Biostat, Seattle, WA 98195 USA. [Jain, Sonia; Raman, Rema; Stein, Murray B.] Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA. RP Bell, KR (reprint author), Univ Washington, Dept Rehabil Med, Box 356490,1959 NE Pacific St, Seattle, WA 98195 USA. EM Icrbell@uw.edu; brockja@uw.edu; fann@uw.edu; wesley.r.cole.ctr@mail.mil; saint@uw.edu; nigel.e.bush.civ@mail.mil; ajlang@ucsd.edu; thart@einstein.edu; mwarren@email.fielding.edu; dilcmen@uw.edu; temIdn@uw.edu; sojain@ucsd.edu; reraman@ucsd.edu; mstein@ucsd.edu FU U.S. Army Medical Research and Materiel Command (USAMRMC) [W81XWH-08-2-0159]; National Institute on Disability and Rehabilitation Research [H133G070143] FX The research reported in this article was supported by the U.S. Army Medical Research and Materiel Command (USAMRMC), USAMRMC Funding Mechanism: Contract# W81XWH-08-2-0159. Supplemental funding for development of the treatment manual and fidelity assessment system was provided by the National Institute on Disability and Rehabilitation Research, grant # H133G070143. NR 67 TC 4 Z9 4 U1 8 U2 14 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1551-7144 EI 1559-2030 J9 CONTEMP CLIN TRIALS JI Contemp. Clin. Trials PD JAN PY 2015 VL 40 BP 54 EP 62 DI 10.1016/j.cct.2014.11.001 PG 9 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA CB6IZ UT WOS:000349732000007 PM 25460344 ER PT B AU Bin, Y AF Bin, Yu BE Dutkiewicz, P Sakwa, R TI The Shanghai Cooperation Organisation, China and Eurasian integration SO EURASIAN INTEGRATION - THE VIEW FROM WITHIN SE Routledge Contemporary Russia and Eastern Europe Series LA English DT Article; Book Chapter C1 [Bin, Yu] Wittenberg Univ, Springfield, OH 45504 USA. [Bin, Yu] Ctr Strateg & Int Studies, Washington, DC 20006 USA. RP Bin, Y (reprint author), US Army War Coll, SSI, Carlisle, PA 17013 USA. NR 55 TC 0 Z9 0 U1 2 U2 3 PU ROUTLEDGE PI ABINGDON PA 2 PARK SQ, MILTON PARK, ABINGDON OX14 4RN, OXFORD, ENGLAND BN 978-1-315-73815-4; 978-1-138-77897-9 J9 ROUTL CONTEMP RUSS E PY 2015 VL 60 BP 256 EP 273 PG 18 WC International Relations; Political Science SC International Relations; Government & Law GA BB9SL UT WOS:000348593100017 ER PT J AU Light, B Dickinson, S Perovich, DK Holland, MM AF Light, Bonnie Dickinson, Suzanne Perovich, Donald K. Holland, Marika M. TI Evolution of summer Arctic sea ice albedo in CCSM4 simulations: Episodic summer snowfall and frozen summers SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article DE Arctic sea ice; albedo; snow on sea ice; melt ponds ID MELT PONDS; SURFACE ALBEDO; 28 YR; OCEAN; COVER; SHEBA; MODEL AB The albedo of Arctic sea ice is calculated from summertime output of twentieth century Community Climate System Model v.4 (CCSM4) simulations. This is compared with an empirical record based on the generalized observations of the summer albedo progression along with melt onset dates determined from remote sensing. Only the contributions to albedo from ice, snow, and ponds are analyzed; fractional ice area is not considered in this assessment. Key factors dictating summer albedo evolution are the timing and extent of ponding and accumulation of snow. The CCSM4 summer sea ice albedo decline was found, on average, to be less pronounced than either the empirical record or the CLARA-SAL satellite record. The modeled ice albedo does not go as low as the empirical record, nor does the low summer albedo last as long. In the model, certain summers were found to retain snow on sea ice, thus inhibiting ice surface melt and the formation or retention of melt ponds. These frozen summers were generally not the summers with the largest spring snow accumulation, but were instead summers that received at least trace snowfall in June or July. When these frozen summers are omitted from the comparison, the model and empirical records are in much better agreement. This suggests that the representation of summer Arctic snowfall events and/or their influence on the sea ice conditions are not well represented in CCSM4 integrations, providing a target for future model development work. C1 [Light, Bonnie; Dickinson, Suzanne] Univ Washington, Appl Phys Lab, Polar Sci Ctr, Seattle, WA 98105 USA. [Perovich, Donald K.] US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Holland, Marika M.] Natl Ctr Atmospher Res, Boulder, CO 80307 USA. RP Light, B (reprint author), Univ Washington, Appl Phys Lab, Polar Sci Ctr, Seattle, WA 98105 USA. EM bonnie@apl.washington.edu FU NSF [ARC-0902040]; ONR [N00014-13-1-0296] FX Data used to perform the analysis in this paper are available from The Earth System Grid Gateway at the National Center for Atmospheric Research. The CCSM4 data sets used were b40.20th.track1.1deg.012 and b40.rcp2_6.1deg.006. The empirical record data are archived at ACADIS (www.aoncadis.org/dataset/arctic_ocean_solar_heating.html). This work was supported by NSF grant ARC-0902040 and ONR grant N00014-13-1-0296 to the University of Washington. The authors thank Taryn Black for programming support and Cecilia Bitz for insightful discussion. Comments from two anonymous reviewers are also acknowledged for significantly improving this manuscript. NR 44 TC 3 Z9 3 U1 1 U2 11 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-9275 EI 2169-9291 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD JAN PY 2015 VL 120 IS 1 BP 284 EP 303 DI 10.1002/2014JC010149 PG 20 WC Oceanography SC Oceanography GA CB8OP UT WOS:000349890000018 ER PT J AU Borodin, O Han, SD Daubert, JS Seo, DM Yun, SH Henderson, WA AF Borodin, Oleg Han, Sang-Don Daubert, James S. Seo, Daniel M. Yun, Sung-Hyun Henderson, Wesley A. TI Electrolyte Solvation and Ionic Association VI. Acetonitrile-Lithium Salt Mixtures: Highly Associated Salts Revisited SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID N,N'-AROMATIC BIDENTATE LIGANDS; MOLECULAR-DYNAMICS SIMULATIONS; AMORPHOUS CONCENTRATED LIQUID; LI+ CATION COORDINATION; POLYMER ELECTROLYTES; CRYSTAL-STRUCTURES; LOCAL STRUCTURES; GROUP-1 SALTS; BASE RATIO; COMPLEXES AB Molecular dynamics (MD) simulations of acetonitrile (AN) mixtures with LiBF4, LiCF3SO3 and LiCF3CO2 provide extensive details about the molecular- and mesoscale-level solution interactions and thus explanations as to why these electrolytes have very different thermal phase behavior and electrochemical/physicochemical properties. The simulation results are in full accord with a previous experimental study of these (AN)(n)-LiX electrolytes. This computational study reveals how the structure of the anions strongly influences the ionic association tendency of the ions, the manner in which the aggregate solvates assemble in solution and the length of time in which the anions remain coordinated to the Li+ cations in the solvates which result in dramatic variations in the transport properties of the electrolytes. (C) The Author(s) 2015. Published by ECS. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License (CC BY, http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse of the work in any medium, provided the original work is properly cited. All rights reserved. C1 [Borodin, Oleg] US Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA. [Han, Sang-Don; Daubert, James S.; Seo, Daniel M.; Henderson, Wesley A.] N Carolina State Univ, Dept Chem & Biomol Engn, Ion Liquids & Electrolytes Energy Technol ILEET L, Raleigh, NC 27695 USA. [Yun, Sung-Hyun] Gwangju Inst Sci & Technol, Sch Environm Sci & Engn, Kwangju 500712, South Korea. [Henderson, Wesley A.] Pacific NW Natl Lab, Energy & Environm Directorate, Electrochem Mat & Syst EMS Grp, Richland, WA 99352 USA. RP Borodin, O (reprint author), US Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA. EM oleg.a.borodin.civ@mail.mil; Wesley.Henderson@pnnl.gov RI Borodin, Oleg/B-6855-2012; OI Borodin, Oleg/0000-0002-9428-5291; Daubert, James/0000-0002-8151-9191 FU Department of Energy [DE-IA01-11EE003413]; U.S. Army Research Laboratory [DE-IA01-11EE003413]; U.S. Department of Energy, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering [DE-SC0002169] FX The computational work was partially supported by an Interagency Agreement between the U.S. Department of Energy and the U.S. Army Research Laboratory under DE-IA01-11EE003413 for the Office of Vehicle Technologies Programs including the Batteries for Advanced Transportation Technologies (BATT) Program. The authors wish to also express their gratitude to the U.S. Department of Energy, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering which supported the evaluation of the computational work and preparation of the manuscript under Award DE-SC0002169. NR 41 TC 8 Z9 8 U1 3 U2 32 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 SOUTH MAIN STREET, PENNINGTON, NJ 08534 USA SN 0013-4651 EI 1945-7111 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PY 2015 VL 162 IS 4 BP A501 EP A510 DI 10.1149/2.0891503jes PG 10 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA CB7SG UT WOS:000349827200002 ER PT J AU Song, HJ Rosano, JM Wang, Y Garson, CJ Prabhakarpandian, B Pant, K Klarmann, GJ Perantoni, A Alvarez, LM Lai, E AF Song, Hongjun Rosano, Jenna M. Wang, Yi Garson, Charles J. Prabhakarpandian, Balabhaskar Pant, Kapil Klarmann, George J. Perantoni, Alan Alvarez, Luis M. Lai, Eva TI Continuous-flow sorting of stem cells and differentiation products based on dielectrophoresis SO LAB ON A CHIP LA English DT Article ID DIELECTRIC-PROPERTIES; CANCER-CELLS; BONE-MARROW; SEPARATION; BLOOD; FRACTIONATION; ENRICHMENT; MICROELECTRODES; REMOVAL; THERAPY AB This paper presents a continuous-flow microfluidic device for sorting stem cells and their differentiation progenies. The principle of the device is based on the accumulation of multiple dielectrophoresis (DEP) forces to deflect cells laterally in conjunction with the alternating on/off electric field to manipulate the cell trajectories. The microfluidic device containing a large array of oblique interdigitated electrodes was fabricated using a combination of standard and soft lithography techniques to generate a PDMS-gold electrode construct. Experimental testing with human mesenchymal stem cells (hMSC) and their differentiation progenies (osteoblasts) was carried out at different flow rates, and clear separation of the two populations was achieved. Most of the osteoblasts experiencing stronger DEP forces were deflected laterally and continuously, following zig-zag trajectories, and moved towards the desired collection outlet, whereas most of the hMSCs remained on the original trajectory due to weaker DEP forces. The experimental measurements were characterized and evaluated quantitatively, and consistent performance was demonstrated. Collection efficiency up to 92% and 67% for hMSCs and osteoblasts, respectively, along with purity up to 84% and 87% was obtained. The experimental results established the feasibility of our microfluidic DEP sorting device for continuous, label-free sorting of stem cells and their differentiation progenies. C1 [Song, Hongjun; Rosano, Jenna M.; Wang, Yi; Garson, Charles J.; Prabhakarpandian, Balabhaskar; Pant, Kapil] CFD Res Corp, Huntsville, AL 35806 USA. [Klarmann, George J.; Perantoni, Alan; Alvarez, Luis M.] NCI, Canc & Dev Biol Lab, Frederick, MD 21702 USA. [Alvarez, Luis M.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. [Lai, Eva] Johns Hopkins Univ, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA. [Lai, Eva] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. RP Wang, Y (reprint author), CFD Res Corp, 701 McMillian Way NW, Huntsville, AL 35806 USA. EM yxw@cfdrc.com FU U.S. Army Medical Research and Materiel Command (USAMRMC) under SBIR contract [W81XWH-12-C-0069] FX This research was sponsored by the U.S. Army Medical Research and Materiel Command (USAMRMC) under SBIR contract no. W81XWH-12-C-0069. GJK and LMA acknowledge Dr. Alan Perantoni and Ms. Nirmala Sharma of the Cancer and Developmental Biology Laboratory for providing access to specialized tissue culture facilities and for discussions regarding analysis of differentiation and development markers. NR 50 TC 22 Z9 23 U1 9 U2 60 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1473-0197 EI 1473-0189 J9 LAB CHIP JI Lab Chip PY 2015 VL 15 IS 5 BP 1320 EP 1328 DI 10.1039/c4lc01253d PG 9 WC Biochemical Research Methods; Chemistry, Multidisciplinary; Nanoscience & Nanotechnology SC Biochemistry & Molecular Biology; Chemistry; Science & Technology - Other Topics GA CB7WC UT WOS:000349838200012 PM 25589423 ER PT J AU Killops, KL Rodriguez, CG Lundberg, P Hawker, CJ Lynd, NA AF Killops, Kato L. Rodriguez, Christina G. Lundberg, Pontus Hawker, Craig J. Lynd, Nathaniel A. TI A synthetic strategy for the preparation of sub-100 nm functional polymer particles of uniform diameter SO POLYMER CHEMISTRY LA English DT Article ID BLOCK-COPOLYMERS; EMULSION POLYMERIZATION; DISPERSION POLYMERIZATION; HAIRY PARTICLES; NANOPARTICLES; SURFACTANTS; STABILIZERS; TECHNOLOGY; STYRENE; LATEX AB An amphiphilic block copolymer surfactant is used to impart peripheral surface functionality to polymer nanoparticles synthesized via emulsion polymerization. Particles ranged in size from ca. 55 nm by SEM (ca. 82 nm by DLS) to just over 200 nm. Particles displaying latent functionality were readily functionalized directly after polymerization using a fluorescent dye. C1 [Killops, Kato L.] US Army, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Rodriguez, Christina G.; Lynd, Nathaniel A.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Joint Ctr Artificial Photosynthesis, Berkeley, CA 94720 USA. [Rodriguez, Christina G.; Hawker, Craig J.; Lynd, Nathaniel A.] Univ Calif Santa Barbara, Mat Res Lab, Santa Barbara, CA 93106 USA. [Lundberg, Pontus] Thermo Fisher Sci, Life Sci Solut, N-2001 Lillestrom, Norway. [Lynd, Nathaniel A.] Univ Texas Austin, McKetta Dept Chem Engn, Austin, TX 78712 USA. RP Killops, KL (reprint author), US Army, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM kathryn.l.killops.civ@mail.mil; lynd@che.utexas.edu FU Department of the Army Basic Research Program; Edgewood Chemical Biological Center; Army Research Office through the Institute for Collaborative Biotechnologies at University of California, Santa Barbara [W911NF-09-D-0001-0028]; MRSEC Program of the National Science Foundation [DMR 1121053] FX This research is funded by the Department of the Army Basic Research Program and sponsored by the Edgewood Chemical Biological Center. Funding for C.R. was provided by the Army Research Office through the Institute for Collaborative Biotechnologies at University of California, Santa Barbara under award number W911NF-09-D-0001-0028. This work was partially supported by the MRSEC Program of the National Science Foundation under Award no. DMR 1121053. NR 37 TC 5 Z9 5 U1 1 U2 28 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1759-9954 EI 1759-9962 J9 POLYM CHEM-UK JI Polym. Chem. PY 2015 VL 6 IS 9 BP 1431 EP 1435 DI 10.1039/c4py01703j PG 5 WC Polymer Science SC Polymer Science GA CB7UB UT WOS:000349832300002 ER PT J AU Thompson, CM Seiter, J Chappell, MA Tappero, RV Proctor, DM Suh, M Wolf, JC Haws, LC Vitale, R Mittal, L Kirman, CR Hays, SM Harris, MA AF Thompson, Chad M. Seiter, Jennifer Chappell, Mark A. Tappero, Ryan V. Proctor, Deborah M. Suh, Mina Wolf, Jeffrey C. Haws, Laurie C. Vitale, Rock Mittal, Liz Kirman, Christopher R. Hays, Sean M. Harris, Mark A. TI Synchrotron-Based Imaging of Chromium and gamma-H2AX Immunostaining in the Duodenum Following Repeated Exposure to Cr(VI) in Drinking Water SO TOXICOLOGICAL SCIENCES LA English DT Article DE hexavalent chromium; Cr(VI); synchrotron; duodenum; carcinogenesis; mode of action; H2AX ID HEXAVALENT CHROMIUM; STEM-CELLS; B6C3F1 MICE; PHARMACOKINETIC MODEL; CANCER; HUMANS; RATS; CARCINOGENESIS; RELEVANCE; TOXICITY AB Current drinking water standards for chromium are for the combined total of both hexavalent and trivalent chromium (Cr(VI) and Cr(III)). However, recent studies have shown that Cr(III) is not carcinogenic to rodents, whereas mice chronically exposed to high levels of Cr(VI) developed duodenal tumors. These findings may suggest the need for environmental standards specific for Cr(VI). Whether the intestinal tumors arose through a mutagenic or non-mutagenic mode of action (MOA) greatly impacts how drinking water standards for Cr(VI) are derived. Herein, X-ray fluorescence (spectro)microscopy (A mu-XRF) was used to image the Cr content in the villus and crypt regions of duodena from B6C3F1 mice exposed to 180 mg/l Cr(VI) in drinking water for 13 weeks. DNA damage was also assessed by gamma-H2AX immunostaining. Exposure to Cr(VI) induced villus blunting and crypt hyperplasia in the duodenum-the latter evidenced by lengthening of the crypt compartment by similar to 2-fold with a concomitant 1.5-fold increase in the number of crypt enterocytes. gamma-H2AX immunostaining was elevated in villi, but not in the crypt compartment. A mu-XRF maps revealed mean Cr levels > 30 times higher in duodenal villi than crypt regions; mean Cr levels in crypt regions were only slightly above background signal. Despite the presence of Cr and elevated gamma-H2AX immunoreactivity in villi, no aberrant foci indicative of transformation were evident. These findings do not support a MOA for intestinal carcinogenesis involving direct Cr-DNA interaction in intestinal stem cells, but rather support a non-mutagenic MOA involving chronic wounding of intestinal villi and crypt cell hyperplasia. C1 [Thompson, Chad M.; Mittal, Liz; Harris, Mark A.] ToxStrategies Inc, Katy, TX 77494 USA. [Seiter, Jennifer; Chappell, Mark A.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Tappero, Ryan V.] Brookhaven Natl Lab, Photon Sci Dept, Upton, NY 11973 USA. [Proctor, Deborah M.; Suh, Mina] ToxStrategies Inc, Mission Viejo, CA 92692 USA. [Wolf, Jeffrey C.] Expt Pathol Labs, Sterling, VA 20166 USA. [Haws, Laurie C.] ToxStrategies Inc, Austin, TX 78731 USA. [Vitale, Rock] Environm Stand Inc, Valley Forge, PA 19482 USA. [Kirman, Christopher R.] Summit Toxicol LLP, Orange Village, OH 44022 USA. [Hays, Sean M.] Summit Toxicol LLP, Allenspark, CO 80510 USA. RP Thompson, CM (reprint author), ToxStrategies Inc, 23123 Cinco Ranch Blvd,Suite 220, Katy, TX 77494 USA. EM cthompson@toxstrategies.com FU Cr(VI) Panel of the American Chemistry Council; DOE, Office of Science, Office of Basic Energy Sciences [DE-AC02-98CH10886] FX This work was supported by the Cr(VI) Panel of the American Chemistry Council.; Use of the NSLS (National Synchrotron Light Source) was supported by the DOE, Office of Science, Office of Basic Energy Sciences, under Contract No. DE-AC02-98CH10886. NR 48 TC 9 Z9 9 U1 1 U2 5 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD JAN PY 2015 VL 143 IS 1 BP 16 EP 25 DI 10.1093/toxsci/kfu206 PG 10 WC Toxicology SC Toxicology GA CC1LH UT WOS:000350101700004 PM 25352572 ER PT J AU Veress, LA Anderson, DR Hendry-Hofer, TB Houin, PR Rioux, JS Garlick, RB Loader, JE Paradiso, DC Smith, RW Rancourt, RC Holmes, WW White, CW AF Veress, Livia A. Anderson, Dana R. Hendry-Hofer, Tara B. Houin, Paul R. Rioux, Jacqueline S. Garlick, Rhonda B. Loader, Joan E. Paradiso, Danielle C. Smith, Russell W. Rancourt, Raymond C. Holmes, Wesley W. White, Carl W. TI Airway Tissue Plasminogen Activator Prevents Acute Mortality Due to Lethal Sulfur Mustard Inhalation SO TOXICOLOGICAL SCIENCES LA English DT Article DE tPA; airway fibrin; sulfur mustard; fibrinolysis; plastic bronchitis ID ACUTE LUNG INJURY; ANALOG INHALATION; OBSTRUCTION; PERSPECTIVE; COAGULATION AB Rationale: Sulfur mustard (SM) is a chemical weapon stockpiled today in volatile regions of the world. SM inhalation causes a life-threatening airway injury characterized by airway obstruction from fibrin casts, which can lead to respiratory failure and death. Mortality in those requiring intubation is more than 80%. No therapy exists to prevent mortality after SM exposure. Our previous work using the less toxic analog of SM, 2-chloroethyl ethyl sulfide, identified tissue plasminogen activator (tPA) an effective rescue therapy for airway cast obstruction (Veress, L. A., Hendry-Hofer, T. B., Loader, J. E., Rioux, J. S., Garlick, R. B., and White, C. W. (2013). Tissue plasminogen activator prevents mortality from sulfur mustard analog-induced airway obstruction. Am. J. Respir. Cell Mol. Biol. 48, 439-447). It is not known if exposure to neat SM vapor, the primary agent used in chemical warfare, will also cause death due to airway casts, and if tPA could be used to improve outcome. Methods: Adult rats were exposed to SM, and when oxygen saturation reached less than 85% (median: 6.5 h), intratracheal tPA or placebo was given under isoflurane anesthesia every 4 h for 48 h. Oxygen saturation, clinical distress, and arterial blood gases were assessed. Microdissection was done to assess airway obstruction by casts. Results: Intratracheal tPA treatment eliminated mortality (0% at 48 h) and greatly improved morbidity after lethal SM inhalation (100% death in controls). tPA normalized SM-associated hypoxemia, hypercarbia, and lactic acidosis, and improved respiratory distress. Moreover, tPA treatment resulted in greatly diminished airway casts, preventing respiratory failure from airway obstruction. Conclusions: tPA given via airway more than 6 h after exposure prevented death from lethal SM inhalation, and normalized oxygenation and ventilation defects, thereby rescuing from respiratory distress and failure. Intra-airway tPA should be considered as a life-saving rescue therapy after a significant SM inhalation exposure incident. C1 [Veress, Livia A.; Hendry-Hofer, Tara B.; Houin, Paul R.; Rioux, Jacqueline S.; Garlick, Rhonda B.; Loader, Joan E.; Smith, Russell W.; Rancourt, Raymond C.; White, Carl W.] Univ Colorado Denver, Dept Pediat, Aurora, CO 80045 USA. [Anderson, Dana R.; Paradiso, Danielle C.; Holmes, Wesley W.] US Army, Med Toxicol Branch, Analyt Toxicol Div, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Veress, LA (reprint author), Univ Colorado Denver, Pediat Airway Res Ctr, Dept Pediat Pulmonol, Mailstop 8615,12700 E 19th Ave, Aurora, CO 80045 USA. EM Livia.Veress@ucdenver.edu FU CounterACT Program, National Institutes of Health (NIH), Office of the Director; National Institute of Environmental Health Sciences (NIEHS) [U54 ES015678] FX This research is supported by the CounterACT Program, National Institutes of Health (NIH), Office of the Director, and the National Institute of Environmental Health Sciences (NIEHS), Grant Number U54 ES015678 (CWW). NR 23 TC 6 Z9 6 U1 0 U2 5 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD JAN PY 2015 VL 143 IS 1 BP 178 EP 184 DI 10.1093/toxsci/kfu225 PG 7 WC Toxicology SC Toxicology GA CC1LH UT WOS:000350101700019 PM 25331496 ER PT J AU Berger, ST Netherland, MD MacDonald, GE AF Berger, Sarah T. Netherland, Michael D. MacDonald, Gregory E. TI Laboratory Documentation of Multiple-Herbicide Tolerance to Fluridone, Norflurazon, and Topramazone in a Hybrid Watermilfoil (Myriophyllum spicatum x M. sibiricum) Population SO WEED SCIENCE LA English DT Article DE Aquatic weeds; herbicide resistance; herbicide tolerance ID HYDRILLA HYDRILLA-VERTICILLATA; EURASIAN WATERMILFOIL; RESISTANT HYDRILLA; PLANT COMMUNITY; TRICLOPYR; PHYTOENE; MILFOIL; LAKE; INHIBITORS; EVOLUTION AB Invasive watermilfoils, specifically Eurasian watermilfoil and the interspecific hybrid of Eurasian watermilfoil x northern watermilfoil, continue to be problematic for water resource managers. Herbicides are often used to control these nuisance weeds and have been historically successful in controlling Eurasian watermilfoil. A population of hybrid watermilfoil from Townline Lake in Michigan has shown increased tolerance to the herbicide fluridone. The objective of this work is to determine if cross-and multiple tolerance have also developed in this population. Eurasian watermilfoil plants collected from multiple sites and plants from Townline Lake were treated with 0, 5, 10, 20, 40, or 80 mu g L-1 of fluridone, norflurazon, or topramezone. Fluridone and norflurazon inhibit phytoene desaturase, whereas topramezone is a 4-hydroxyphenylpyruvate dioxygenase-inhibiting herbicide. Chlorophyll fluorescence (F-v/F-m) and pigment content was measured at 10 d after treatment. Townline Lake plants responded differently from susceptible plants when treated with fluridone, norflurazon, and topramezone at 40 mu g L-1. These results indicate that the Townline population of hybrid watermilfoil has inherent tolerance to multiple herbicide modes of action. These results are especially significant as topramezone has recently been labeled for aquatic use. Screening of additional herbicides to determine potential herbicide tolerance of the Townline Lake population is recommended. Nomenclature: Fluridone; norflurazon; topramezone; Eurasian watermilfoil, Myriophyllum spicatum L.; hybrid watermilfoil, M. spicatum x M. sibiricum; northern watermilfoil, M. sibiricum Komarov. C1 [Berger, Sarah T.; MacDonald, Gregory E.] Univ Florida, Dept Agron, Gainesville, FL 32611 USA. [Netherland, Michael D.] US Army, Gainesville, FL 32653 USA. RP Netherland, MD (reprint author), US Army, Gainesville, FL 32653 USA. EM mdnether@ufl.edu NR 28 TC 5 Z9 5 U1 5 U2 21 PU WEED SCI SOC AMER PI LAWRENCE PA 810 EAST 10TH ST, LAWRENCE, KS 66044-8897 USA SN 0043-1745 EI 1550-2759 J9 WEED SCI JI Weed Sci. PD JAN-MAR PY 2015 VL 63 IS 1 BP 235 EP 241 DI 10.1614/WS-D-14-00085.1 PG 7 WC Agronomy; Plant Sciences SC Agriculture; Plant Sciences GA CB7BW UT WOS:000349782100003 ER PT J AU Karthik, VU Sivasuthan, S Rahunanthan, A Thyagarajan, RS Jayakumar, P Udpa, L Hoole, SRH AF Karthik, Victor U. Sivasuthan, Sivamayam Rahunanthan, Arunasalam Thyagarajan, Ravi S. Jayakumar, Paramsothy Udpa, Lalita Hoole, S. Ratnajeevan H. TI Faster, more accurate, parallelized inversion for shape optimization in electroheat problems on a graphics processing unit (GPU) with the real-coded genetic algorithm SO COMPEL-THE INTERNATIONAL JOURNAL FOR COMPUTATION AND MATHEMATICS IN ELECTRICAL AND ELECTRONIC ENGINEERING LA English DT Article DE CAD; Finite element methods; Applied electromagnetics; Computational methods; Genetic algorithms; Field optimization ID OPTIMAL-DESIGN; FINITE-ELEMENTS; HYPERTHERMIA; COMPUTATION; DEVICES; 3-D AB Purpose - Inverting electroheat problems involves synthesizing the electromagnetic arrangement of coils and geometries to realize a desired heat distribution. To this end two finite element problems need to be solved, first for the magnetic fields and the joule heat that the associated eddy currents generate and then, based on these heat sources, the second problem for heat distribution. This two-part problem needs to be iterated on to obtain the desired thermal distribution by optimization. Being a time consuming process, the purpose of this paper is to parallelize the process using the graphics processing unit (GPU) and the real-coded genetic algorithm, each for both speed and accuracy. Design/methodology/approach - This coupled problem represents a heavy computational load with long wait-times for results. The GPU has recently been demonstrated to enhance the efficiency and accuracy of the finite element computations and cut down solution times. It has also been used to speedup the naturally parallel genetic algorithm. The authors use the GPU to perform coupled electroheat finite element optimization by the genetic algorithm to achieve computational efficiencies far better than those reported for a single finite element problem. In the genetic algorithm, coding objective functions in real numbers rather than binary arithmetic gives added speed and accuracy. Findings - The feasibility of the method proposed to reduce computational time and increase accuracy is established through the simple problem of shaping a current carrying conductor so as to yield a constant temperature along a line. The authors obtained a speedup (CPU time to GPU time ratio) saturating to about 28 at a population size of 500 because of increasing communications between threads. But this far better than what is possible on a workstation. Research limitations/implications - By using the intrinsically parallel genetic algorithm on a GPU, large complex coupled problems may be solved very quickly. The method demonstrated here without accounting for radiation and convection, may be trivially extended to more completely modeled electroheat systems. Since the primary purpose here is to establish methodology and feasibility, the thermal problem is simplified by neglecting convection and radiation. While that introduces some error, the computational procedure is still validated. Practical implications - The methodology established has direct applications in electrical machine design, metallurgical mixing processes, and hyperthermia treatment in oncology. In these three practical application areas, the authors need to compute the exciting coil (or antenna) arrangement (current magnitude and phase) and device geometry that would accomplish a desired heat distribution to achieve mixing, reduce machine heat or burn cancerous tissue. This process presented does it more accurately and speedily. Social implications - Particularly the above-mentioned application in oncology will alleviate human suffering through use in hyperthermia treatment planning in cancer treatment. The method presented provides scope for new commercial software development and employment. Originality/value - Previous finite element shape optimization of coupled electroheat problems by this group used gradient methods whose difficulties are explained. Others have used analytical and circuit models in place of finite elements. This paper applies the massive parallelization possible with GPUs to the inherently parallel genetic algorithm, and extends it from single field system problems to coupled problems, and thereby realizes practicable solution times for such a computationally complex problem. Further, by using GPU computations rather than CPU, accuracy is enhanced. And then by using real number rather than binary coding for object functions, further accuracy and speed gains are realized. C1 [Karthik, Victor U.; Sivasuthan, Sivamayam; Udpa, Lalita; Hoole, S. Ratnajeevan H.] Michigan State Univ, Dept Elect & Comp Engn, E Lansing, MI 48824 USA. [Rahunanthan, Arunasalam] Edinboro Univ, Dept Math & Comp Sci, Edinboro, PA USA. [Thyagarajan, Ravi S.; Jayakumar, Paramsothy] US Army Tank Automot Res Dev & Engn Ctr, Warren, MI USA. RP Hoole, SRH (reprint author), Michigan State Univ, Dept Elect & Comp Engn, E Lansing, MI 48824 USA. EM hoole@egr.msu.edu NR 39 TC 1 Z9 1 U1 2 U2 7 PU EMERALD GROUP PUBLISHING LIMITED PI BINGLEY PA HOWARD HOUSE, WAGON LANE, BINGLEY BD16 1WA, W YORKSHIRE, ENGLAND SN 0332-1649 J9 COMPEL JI Compel-Int. J. Comp. Math. Electr. Electron. Eng. PY 2015 VL 34 IS 1 BP 344 EP 356 DI 10.1108/COMPEL-06-2014-0146 PG 13 WC Computer Science, Interdisciplinary Applications; Engineering, Electrical & Electronic; Mathematics, Applied SC Computer Science; Engineering; Mathematics GA CB5BE UT WOS:000349641700021 ER PT J AU Field, AE Jones, CL Kelly, R Marko, ST Kern, SJ Ricol, PJ AF Field, Amy E. Jones, Cynthia L. Kelly, Richard, III Marko, Shannon T. Kern, Steven J. Ricol, Pedro J. TI Measurement of Fecal Corticosterone Metabolites as a Predictor of the Habituation of Rhesus Macaques (Macaca mulatta) to Jacketing SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE LA English DT Article ID SELF-INJURIOUS-BEHAVIOR; CHIMPANZEES PAN-TROGLODYTES; URINARY CORTISOL RESPONSES; NONHUMAN-PRIMATES; PERSONALITY DIMENSIONS; LONGTAILED MACAQUES; IMMUNE FUNCTION; ROOM CHANGE; STRESS; MONKEYS AB Jacket use in NHP is a common practice and is often considered a form of refinement during experiments necessitating extended periods of catheterization. An important consideration when using jackets is the physiologic effects that jacketing has on NHP and its potential to confound research. Several studies have evaluated the stress response and habituation of NHP to various forms of restraint, but none have looked directly at the timeframe necessary for the habituation of rhesus macaques (Macaca mulatta) to jackets. We set out to determine whether 3 d was a sufficient timeframe for this species to become habituated to a jacket, with or without an undershirt, by evaluating 2 major physiologic parameters. After jacket placement, we measured food consumption and collected fecal samples to measure fecal corticosterone metabolites (FCM) daily for 2 wk. FCM measurements for NHP without undershirts were significantly increased for days 2 and 3 after jacketing before returning to baseline levels. FCM measurements for NHP with undershirts were significantly increased for only 1 d after jacketing, suggesting that the undershirt has a, positive effect on jacket habituation. There were no measurable differences in food consumption during the jacket habituation period. Furthermore, no significant differences were noted between sexes. These findings suggest that FCM levels return to baseline 3 d after jacketing and could be a useful predictor of jacket habituation in rhesus macaques. C1 [Field, Amy E.; Jones, Cynthia L.; Kelly, Richard, III; Marko, Shannon T.; Ricol, Pedro J.] US Army, Med Res Inst Infect Dis, Vet Med Div, Ft Detrick, MD 21702 USA. [Kern, Steven J.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Field, AE (reprint author), US Army, Med Res Inst Infect Dis, Vet Med Div, Ft Detrick, MD 21702 USA. EM amy.e.field.mil@mail.mil FU Vet Med Division under USAMRIID [150874] FX Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the US Army or the Department of Defense. We thank MAJ Krystal Bean, LTC Carrie Benton, and Dr Emily Bailey for their editorial review. We thank Dr Janine Brown from the Smithsonian Conservation Biology Institute for analyzing the fecal corticosterone metabolite samples. In addition we thank the USAMRIID Veterinary Medicine NHP and Behavior Management Sections for study support. This research was funded by the Vet Med Division under USAMRIID project number 150874. NR 42 TC 1 Z9 1 U1 1 U2 6 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1559-6109 J9 J AM ASSOC LAB ANIM JI J. Amer. Assoc. Lab. Anim. Sci. PD JAN PY 2015 VL 54 IS 1 BP 59 EP 65 PG 7 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA CB4DF UT WOS:000349577700010 PM 25651092 ER PT J AU Woodring, JL Patel, G Erath, J Behera, R Lee, PJ Leed, SE Rodriguez, A Sciotti, RJ Mensa-Wilmot, K Pollastri, MP AF Woodring, Jennifer L. Patel, Gautam Erath, Jessey Behera, Ranjan Lee, Patricia J. Leed, Susan E. Rodriguez, Ana Sciotti, Richard J. Mensa-Wilmot, Kojo Pollastri, Michael P. TI Evaluation of aromatic 6-substituted thienopyrimidines as scaffolds against parasites that cause trypanosomiasis, leishmaniasis, and malaria SO MEDCHEMCOMM LA English DT Article ID TYROSINE KINASE INHIBITOR; AFRICAN SLEEPING SICKNESS; DRUG DISCOVERY; LEAD COMPOUND; CANCER; LAPATINIB; TARGETS; SCREEN; GROWTH AB Target repurposing is a proven method for finding new lead compounds that target Trypanosoma brucei, the causative agent of human African trypanosomiasis. Due to the recent discovery of a lapatinib-derived analog 2 with excellent potency against T. brucei (EC50 = 42 nM) and selectivity over human host cells, we have explored other classes of human tyrosine kinase inhibitor scaffolds in order to expand the range of chemotypes for pursuit. Following library expansion, we found compound 11e to have an EC50 of 84 nM against T. brucei cells while maintaining selectivity over human hepatocytes. In addition, the library was tested against causative agents of Chagas' disease, leishmaniasis, and malaria. Two analogs with sub-micromolar potencies for T. cruzi (4j) and Plasmodium falciparum (11j) were discovered, along with an analog with considerable potency against Leishmania major amastigotes (4e). Besides identifying new and potent protozoan growth inhibitors, these data highlight the value of concurrent screening of a chemical library against different protozoan parasites. C1 [Woodring, Jennifer L.; Patel, Gautam; Pollastri, Michael P.] Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA. [Erath, Jessey; Rodriguez, Ana] NYU, Sch Med, Dept Microbiol, Div Parasitol, New York, NY 10010 USA. [Behera, Ranjan; Mensa-Wilmot, Kojo] Univ Georgia, Dept Cellular Biol, Athens, GA 30602 USA. [Lee, Patricia J.; Leed, Susan E.; Sciotti, Richard J.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Rodriguez, Ana] NYU, Sch Med, Antiinfect Screening Core, New York, NY 10010 USA. RP Pollastri, MP (reprint author), Northeastern Univ, Dept Chem & Chem Biol, 360 Huntington Ave, Boston, MA 02115 USA. EM m.pollastri@neu.edu OI Rodriguez, Ana/0000-0002-0060-3405 FU NIH [R01AI082577, R56AI099476, R21AI076647] FX This work was funded in part by NIH grants R01AI082577 (MPP), R56AI099476 (MPP and KM-W), and R21AI076647 (KM-W). We thank GlaxoSmithKline for providing GW837016X that was used in exploratory studies with T. brucei. We appreciate a free academic license for the OpenEye suite of software, and are grateful to AstraZeneca for performing the in vitro ADME experiments described in this manuscript. NR 24 TC 5 Z9 5 U1 0 U2 6 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2040-2503 EI 2040-2511 J9 MEDCHEMCOMM JI MedChemComm PY 2015 VL 6 IS 2 BP 339 EP 346 DI 10.1039/c4md00441h PG 8 WC Biochemistry & Molecular Biology; Chemistry, Medicinal SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy GA CB5WV UT WOS:000349699600011 PM 25685309 ER PT J AU Deng-Bryant, Y Readnower, RD Leung, LY Cunningham, TL Shear, DA Tortella, FC AF Deng-Bryant, Ying Readnower, Ryan D. Leung, Lai Yee Cunningham, Tracy L. Shear, Deborah A. Tortella, Frank C. TI Treatment with amnion-derived cellular cytokine solution (ACCS) induces persistent motor improvement and ameliorates neuroinflammation in a rat model of penetrating ballistic-like brain injury SO RESTORATIVE NEUROLOGY AND NEUROSCIENCE LA English DT Article DE Amnion-derived cellular cytokine solution; penetrating ballistic-like brain injury; rotarod; morris water maze; neuroinflammation; microglia; neutrophil; neurodegeneration ID WHITE-MATTER INJURY; CLOSED-HEAD INJURY; BARRIER PERMEABILITY; GROWTH-FACTOR; NEONATAL-RAT; FUNCTIONAL RECOVERY; MICROGLIAL CELLS; IMMUNE-RESPONSE; EDEMA FORMATION; SMALL MOLECULES AB Purpose: The present work compared the behavioral outcomes of ACCS therapy delivered either intravenously (i.v.) or intracerebroventricularly (i.c.v.) after penetrating ballistic-like brain injury (PBBI). Histological markers for neuroinflammation and neurodegeneration were employed to investigate the potential therapeutic mechanism of ACCS. Methods: Experiment-1, ACCS was administered either i.v. or i.c.v. for 1 week post-PBBI. Outcome metrics included behavioral (rotarod and Morris water maze) and gross morphological assessments. Experiment-2, rats received ACCS i.c.v for either 1 or 2 weeks post-PBBI. The inflammatory response was determined by immunohistochemistry for neutrophils and microglia reactivity. Neurodegeneration was visualized using silver staining. Results: Both i.v. and i.c.v. delivery of ACCS improved motor outcome but failed to improve cognitive outcome or tissue sparing. Importantly, only i.c.v. ACCS treatment produced persistent motor improvements at a later endpoint. The i.c.v. ACCS treatment significantly reduced PBBI-induced increase in myeloperoxidase (MPO) and ionized calcium binding adaptor molecule 1 (Iba1) expression. Concomitant reduction of both Iba1 and silver staining were detected in corpus callosum with i.c.v. ACCS treatment. Conclusions: ACCS, as a treatment for TBI, showed promise with regard to functional (motor) recovery and demonstrated strong capability to modulate neuroinflammatory responses that may underline functional recovery. However, the majority of beneficial effects appear restricted to the i.c.v. route of ACCS delivery, which warrants future studies examining delivery routes (e.g. intranasal delivery) which are more clinically viable for the treatment of TBI. C1 [Deng-Bryant, Ying; Readnower, Ryan D.; Leung, Lai Yee; Cunningham, Tracy L.; Shear, Deborah A.; Tortella, Frank C.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat Branch, Silver Spring, MD 20910 USA. RP Deng-Bryant, Y (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat Branch, 503 Robert Grant Ave Room 2W12, Silver Spring, MD 20910 USA. EM ying.d.bryant.civ@mail.mil FU CDMRP [W81XWH-08-2-0127] FX The authors are grateful for the excellent technical assistance provided by Christopher van der Merwe and Francis P. Bustos. This work was funded by CDMRP W81XWH-08-2-0127. NR 53 TC 1 Z9 1 U1 0 U2 2 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 0922-6028 EI 1878-3627 J9 RESTOR NEUROL NEUROS JI Restor. Neurol. Neurosci. PY 2015 VL 33 IS 2 BP 189 EP 203 DI 10.3233/RNN-140455 PG 15 WC Neurosciences SC Neurosciences & Neurology GA CB7UX UT WOS:000349835000009 PM 25588460 ER PT J AU Akers, KS Rowan, MP Niece, KL Stewart, IJ Mende, K Cota, JM Murray, CK Chung, KK AF Akers, Kevin S. Rowan, Matthew P. Niece, Krista L. Stewart, Ian J. Mende, Katrin Cota, Jason M. Murray, Clinton K. Chung, Kevin K. TI Colistin Pharmacokinetics in Burn Patients during Continuous Venovenous Hemofiltration SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID PERFORMANCE LIQUID-CHROMATOGRAPHY; RENAL REPLACEMENT THERAPY; CRITICALLY-ILL PATIENTS; HIGH-VOLUME HEMOFILTRATION; FIELD GEL-ELECTROPHORESIS; ACUTE KIDNEY INJURY; ACINETOBACTER-BAUMANNII; POPULATION PHARMACOKINETICS; PSEUDOMONAS-AERUGINOSA; PROTEIN-BINDING AB While colistin is considered a last resort for the treatment of multidrug-resistant Gram-negative bacterial infections, there has been an increase in its use due to the increasing prevalence of drug-resistant infections worldwide. The pharmacology of colistin is complex, and pharmacokinetic data are limited, especially in patients requiring renal replacement therapy. As a result, dosing for patients who require renal replacement remains a challenge. Here, we present pharmacokinetic data for colistin from two burn patients (37 and 68 years old) infected with colistin-susceptible isoclonal Acinetobacter baumannii and receiving continuous venovenous hemofiltration (CVVH). To our knowledge, we are the first to examine data from before and during CVVH (for one patient), allowing analysis of the effect of CVVH on colistin pharmacokinetics. Pharmacokinetic/pharmacodynamic analysis indicated that a dose increase from 1.5 to 2.2 mg/kg of body weight colistin base activity on CVVH was insufficient to satisfy the target parameter of an AUC24/MIC (area under the concentration- time curve over 24 h in the steady state divided by the MIC) of >= 60 at an MIC of >= 1 mu g/ml in one patient with residual endogenous renal function. Plasma concentrations of colistin ranged from 0 to 15 mu g/ml, with free colistin levels ranging from 0.4 to 2.2 mu g/ml. While both patients resolved their clinical infections and survived to discharge, colistin-resistant colonizing isolates resulted from therapy in one patient. The variabilities observed in colistin concentrations and pharmacokinetic characteristics highlight the importance of pharmacokinetic monitoring of antibiotics in patients undergoing renal replacement therapy. C1 [Akers, Kevin S.; Rowan, Matthew P.; Niece, Krista L.; Chung, Kevin K.] United States Army, Inst Surg Res, Ft Sam Houston, San Antonio, TX USA. [Akers, Kevin S.; Stewart, Ian J.; Mende, Katrin; Murray, Clinton K.] Brooke Army Med Ctr, Ft Sam Houston, San Antonio, TX USA. [Mende, Katrin] Infect Dis Clin Res Program, Bethesda, MD USA. [Cota, Jason M.] Univ Incarnate Word, Feik Sch Pharm, San Antonio, TX USA. [Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Hlth Sci, Bethesda, MD USA. RP Akers, KS (reprint author), United States Army, Inst Surg Res, Ft Sam Houston, San Antonio, TX USA. EM kevin.s.akers.mil@mail.mil FU Defense Medical Research & Development Program (DMRDP) Military Infectious Disease Clinical Trial Award (MID-CTA) [D_MIDCTA_I_12_J2_299]; U.S. Department of Energy; USAMRMC FX This work was supported by Defense Medical Research & Development Program (DMRDP) Military Infectious Disease Clinical Trial Award (MID-CTA) D_MIDCTA_I_12_J2_299 and, in part, by an appointment to the Postgraduate Research Participation Program at the U.S. Army Institute of Surgical Research administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USAMRMC. NR 45 TC 9 Z9 9 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD JAN PY 2015 VL 59 IS 1 BP 46 EP 52 DI 10.1128/AAC.03783-14 PG 7 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA CA0LO UT WOS:000348609500005 PM 25313211 ER PT J AU Taylor, S Park, E Bullion, K Dontsova, K AF Taylor, Susan Park, Eileen Bullion, Katherine Dontsova, Katerina TI Dissolution of three insensitive munitions formulations SO CHEMOSPHERE LA English DT Article DE Insensitive munitions; DNAN; NTO; Dissolution; Micro-computed tomography ID DETONATION; NTO; PERCHLORATE; RESIDUES; RDX; HMX AB The US military fires live munitions during training. To save soldiers lives both during training and war, the military is developing insensitive munitions (IM) that minimize unintentional detonations. Some of the compounds in the IM formulation are, however, very soluble in water, raising environmental concerns about their fate and transport. We measured the dissolution of three of these IM formulations, IMX101, IMX104 and PAX21 using laboratory drip tests and studied the accompanying changes in particle structure using micro computed tomography. Our laboratory drip tests mimic conditions on training ranges, where spatially isolated particles of explosives scattered by partial detonations are dissolved by rainfall. We found that the constituents of these IM formulations dissolve sequentially and in the order predicted by their aqueous solubility. The order of magnitude differences in solubility among their constituents produce water solutions whose compositions and concentrations vary with time. For IMX101 and IMX104, that contain 3-nitro-1,2,4-triazol-5-one (NTO), the solutions also vary in pH. The good mass balances measured for the drip tests indicate that the formulations are not being photo-or bio-transformed under laboratory conditions. Published by Elsevier Ltd. C1 [Taylor, Susan; Park, Eileen; Bullion, Katherine] Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Dontsova, Katerina] Univ Arizona, Tucson, AZ 85721 USA. RP Taylor, S (reprint author), Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM Susan.Taylor@erdc.dren.mil FU Women in Science Program; Strategic Environmental Research and Development Program [SERDP ER- 2220, ER-2219] FX At Dartmouth College, we thank Drs. Mark McPeek and Charles Daghlian for training on and use of the mu CT scanner and the Women in Science Program for supporting two of the authors, KB and EP. We thank Anthony Di Stasio of Picatinny Arsenal for providing undetonated IM pieces and my colleagues Michael and Marianne Walsh for their help in the field and in the laboratory. Lastly, we thank Dr. Andrea Leeson of the Strategic Environmental Research and Development Program for funding this work under projects SERDP ER- 2220 and ER-2219. NR 27 TC 7 Z9 7 U1 5 U2 36 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD JAN PY 2015 VL 119 BP 342 EP 348 DI 10.1016/j.chemosphere.2014.06.050 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA AY7KQ UT WOS:000347739600046 PM 25043961 ER PT J AU Hughes, BH Greenberg, NJ Yang, TC Skonberg, DI AF Hughes, Brianna H. Greenberg, Neil J. Yang, Tom C. Skonberg, Denise I. TI Effects of Rigor Status during High-Pressure Processing on the Physical Qualities of Farm-Raised Abalone (Haliotis rufescens) SO JOURNAL OF FOOD SCIENCE LA English DT Article DE abalone; high-pressure processing; rigor; texture ID GADUS-MORHUA L.; ATLANTIC SALMON; HEAT TREATMENT; SHELF-LIFE; MUSCLE; STORAGE; COD; PRESSURIZATION; TEMPERATURE; ATTRIBUTES AB High-pressure processing (HPP) is used to increase meat safety and shelf-life, with conflicting quality effects depending on rigor status during HPP. In the seafood industry, HPP is used to shuck and pasteurize oysters, but its use on abalones has only been minimally evaluated and the effect of rigor status during HPP on abalone quality has not been reported. Farm-raised abalones (Haliotis rufescens) were divided into 12 HPP treatments and 1 unprocessed control treatment. Treatments were processed pre-rigor or post-rigor at 2 pressures (100 and 300 MPa) and 3 processing times (1, 3, and 5 min). The control was analyzed post-rigor. Uniform plugs were cut from adductor and foot meat for texture profile analysis, shear force, and color analysis. Subsamples were used for scanning electron microscopy of muscle ultrastructure. Texture profile analysis revealed that post-rigor processed abalone was significantly (P < 0.05) less firm and chewy than pre-rigor processed irrespective of muscle type, processing time, or pressure. L values increased with pressure to 68.9 at 300 MPa for pre-rigor processed foot, 73.8 for post-rigor processed foot, 90.9 for pre-rigor processed adductor, and 89.0 for post-rigor processed adductor. Scanning electron microscopy images showed fraying of collagen fibers in processed adductor, but did not show pressure-induced compaction of the foot myofibrils. Post-rigor processed abalone meat was more tender than pre-rigor processed meat, and post-rigor processed foot meat was lighter in color than pre-rigor processed foot meat, suggesting that waiting for rigor to resolve prior to processing abalones may improve consumer perceptions of quality and market value. C1 [Hughes, Brianna H.; Skonberg, Denise I.] Univ Maine, Sch Food & Agr, Orono, ME 04469 USA. [Greenberg, Neil J.] Univ Maine, Inst Aquaculture Res, Orono, ME 04469 USA. [Yang, Tom C.] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. RP Skonberg, DI (reprint author), Univ Maine, Sch Food & Agr, 5735 Hitchner Hall, Orono, ME 04469 USA. EM Denise.Skonberg@umit.maine.edu FU UMaine ADVANCE Rising Tide Center; Aquaculture Research Inst. FX This manuscript is nr 3394 the Univ. of Maine Agricultural and Forest Experiment Station. The authors thank Dr. William Halteman, Dr. Seth Tyler, and Kelly Edwards for sharing their expertise, Anne McCormack, Marissa Rublee, Katherine Davis-Dentici, Beth Fulton, Richard Lopes, and Mary Scerra for their invaluable assistance, Brad Buckley and The Abalone Farm for generously discounting the abalone, and the UMaine ADVANCE Rising Tide Center and the Aquaculture Research Inst. for funding portions of this research. NR 39 TC 0 Z9 0 U1 2 U2 13 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-1147 EI 1750-3841 J9 J FOOD SCI JI J. Food Sci. PD JAN PY 2015 VL 80 IS 1 BP C40 EP C48 DI 10.1111/1750-3841.12717 PG 9 WC Food Science & Technology SC Food Science & Technology GA CB0HD UT WOS:000349305600007 PM 25471900 ER PT J AU Ali, SK Reveles, KR Davis, R Mortensen, EM Frei, CR Mansi, I AF Ali, Sayed K. Reveles, Kelly R. Davis, Richard Mortensen, Eric M. Frei, Christopher R. Mansi, Ishak TI The Association of Statin Use and Gonado-Sexual Function in Women: A Retrospective Cohort Analysis SO JOURNAL OF SEXUAL MEDICINE LA English DT Article DE Menstrual Disorders; Menopausal Disorders; Infertility; Ovarian Dysfunction; Sexual Dysfunction; Statin ID POLYCYSTIC-OVARY-SYNDROME; RANDOMIZED CONTROLLED-TRIALS; HMG-COA REDUCTASE; QUALITY-OF-LIFE; LIPOPROTEIN CHOLESTEROL; MENOPAUSAL TRANSITION; ERECTILE DYSFUNCTION; PROPENSITY SCORES; CLINICAL-TRIAL; HORMONE-LEVELS AB IntroductionIt has been hypothesized that statins reduce sex hormone biosynthesis through hepatic inhibition of cholesterol synthesis, which is a precursor of androstenedione and estradiol. Such a reduction has been associated with menstrual irregularities, menopausal disorders, infertility, and low libido, but studies are conflicting. Few studies have evaluated the clinical effects of statins on gonadal-sexual function in women. AimTo compare the risk of gonado-sexual dysfunction in statin users vs. nonusers. MethodsThis was a retrospective cohort study of all female, adult patients (30-85 years) enrolled in the Tricare Prime/Plus San Antonio catchment area. Using 79 baseline characteristics, we created a propensity score-matched cohort of statin users and nonusers. The study duration was divided into a baseline period (October 1, 2003 to September 30, 2005) to describe patient baseline characteristics and a follow-up period (October 1, 2005 to March 1, 2012) to determine patient outcomes. Statin users were defined as those prescribed a statin for 3 months between October 1, 2004 and September 30, 2005. Logistic regression was used to determine the association of statin use with patient outcomes. Main Outcome MeasuresOutcomes included menstrual disorders, menopausal disorders, infertility, and ovarian/sexual dysfunction during the follow-up period. Outcomes were identified using inpatient or outpatient InternationalClassification ofDiseases, NinthRevision,ClinicalModification codes as defined by the Agency for Healthcare Research and Quality's Clinical Classifications Software. ResultsOf 22,706 women who met study criteria, we propensity score-matched 2,890 statin users with 2,890 nonusers; mean age 5812 years. Statin use was not significantly associated with menstrual disorders (OR 0.97; 95% CI 0.81-1.16), menopausal disorders (OR 0.92; 95% CI 0.83-1.02), infertility (OR 0.79; 95% CI 0.36-1.73), or ovarian/sexual dysfunction (OR 1.18; 95% CI 0.83-1.70). ConclusionsStatin use was not associated with higher risk of gonado-sexual dysfunction in women. Ali SK, Reveles KR, Davis R, Mortensen EM, Frei CR, and Mansi I. The association of statin use and gonado-sexual function in women: A retrospective cohort analysis. J Sex Med 2015;12:83-92. C1 [Ali, Sayed K.] VA South Texas Hlth Care Syst, Dept Med, San Antonio, TX USA. [Ali, Sayed K.] Univ Texas Hlth Sci Ctr San Antonio, Div Hosp Med, San Antonio, TX 78229 USA. [Ali, Sayed K.; Frei, Christopher R.] Univ Texas Austin, Coll Pharm, Pharmacotherapy Div, Austin, TX 78712 USA. [Reveles, Kelly R.; Frei, Christopher R.] Univ Texas Hlth Sci Ctr, Sch Med, Pharmacotherapy Educ & Res Ctr, San Antonio, TX USA. [Davis, Richard] Brooke Army Med Ctr, Dept Med, San Antonio, TX USA. [Mortensen, Eric M.; Mansi, Ishak] VA North Texas Hlth Care Syst, Dept Internal Med, Dallas, TX 75216 USA. [Mortensen, Eric M.] Univ Texas Southwestern Med Ctr, Dallas, TX USA. [Mansi, Ishak] Univ Texas Southwestern, Dept Med, Dallas, TX USA. [Mansi, Ishak] Univ Texas Southwestern, Dept Clin Sci, Div Outcomes & Hlth Serv Res, Dallas, TX USA. RP Mansi, I (reprint author), VA North Texas Hlth Care Syst, Internal Med Serv, E111,4500 S Lancaster Rd, Dallas, TX 75216 USA. EM Ishak.Mansi@va.gov OI Mortensen, Eric/0000-0002-3880-5563 FU NCRR NIH HHS [KL2 RR025766] NR 49 TC 1 Z9 1 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1743-6095 EI 1743-6109 J9 J SEX MED JI J. Sex. Med. PD JAN PY 2015 VL 12 IS 1 BP 83 EP 92 DI 10.1111/jsm.12736 PG 10 WC Urology & Nephrology SC Urology & Nephrology GA CA4CO UT WOS:000348852100010 PM 25382624 ER PT J AU Davis, R Reveles, KR Ali, SK Mortensen, EM Frei, CR Mansi, I AF Davis, Richard Reveles, Kelly R. Ali, Sayed K. Mortensen, Eric M. Frei, Christopher R. Mansi, Ishak TI Statins and Male Sexual Health: A Retrospective Cohort Analysis SO JOURNAL OF SEXUAL MEDICINE LA English DT Article DE Benign Prostatic Hypertrophy; Erectile Dysfunction; Male Infertility; Testicular Dysfunction; Psychosexual Dysfunction; Statin ID BENIGN PROSTATIC HYPERPLASIA; QUALITY-OF-LIFE; URINARY-TRACT SYMPTOMS; ERECTILE-DYSFUNCTION; ATORVASTATIN IMPROVES; CHOLESTEROL LEVELS; SERUM-CHOLESTEROL; HEART-DISEASE; RISK-FACTORS; DRUG-USE AB IntroductionConflicting reports exist regarding the role of statins in male gonadal and sexual function. Some studies report a beneficial effect, particularly for erectile dysfunction (ED), through statins' anti-inflammatory and cardiovascular protective properties. Others suggest that statins might be associated with sexual dysfunction through negative effects on hormone levels. AimThis study aims to compare the risk of gonadal or sexual dysfunction in statin users vs. nonusers in a single-payer healthcare system. MethodsThis was a retrospective cohort study of all male patients (30-85 years) enrolled in the Tricare San Antonio market. Using 79 baseline characteristics, we created a propensity score-matched cohort of statin users and nonusers. The study duration was divided into a baseline period (October 1, 2003 to September 30, 2005) to describe patient baseline characteristics, and a follow-up period (October 1, 2005 to March 1, 2012) to determine patient outcomes. Statin users were defined as those prescribed a statin for 3 months between October 1, 2004 and September 30, 2005. Main Outcome MeasuresOutcomes were identified as the occurrence of benign prostatic hypertrophy (BPH), ED, infertility, testicular dysfunction, or psychosexual dysfunction during the follow-up period as identified by inpatient or outpatient InternationalClassification ofDiseases, 9thRevision, ClinicalModification codes. Logistic regression was used to determine the association of statin use with patient outcomes. ResultsOf 20,731 patients who met study criteria, we propensity score-matched 3,302 statin users with 3,302 nonusers. Statin use in men was not significantly associated with an increased or decreased risk of BPH (odds ratio [OR] 1.08; 95% confidence interval [CI] 0.97-1.19), ED (OR 1.01; 95% CI 0.90-1.13), infertility (OR 1.22; 95% CI 0.66-2.29), testicular dysfunction (OR 0.91; 95% CI 0.73-1.14), or psychosexual dysfunction (OR 1.03; 95% CI 0.94-1.14). ConclusionsStatin use was not associated with increased risk of being diagnosed with gonadal or sexual dysfunction in men. Further studies using a larger sample may be needed. Davis R, Reveles KR, Ali SK, Mortensen EM, Frei CR, and Mansi I. Statins and male sexual health: A retrospective cohort analysis. J Sex Med 2015;12:158-167. C1 [Davis, Richard] Brooke Army Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. [Reveles, Kelly R.; Frei, Christopher R.] Univ Texas Austin, Coll Pharm, Pharmacotherapy Div, Austin, TX 78712 USA. [Reveles, Kelly R.; Frei, Christopher R.] Univ Texas Hlth Sci Ctr San Antonio, Sch Med, Pharmacotherapy Educ & Res Ctr, San Antonio, TX 78229 USA. [Ali, Sayed K.] Univ Texas Hlth Sci Ctr San Antonio, VA South Texas Hlth Care Syst, San Antonio, TX 78229 USA. [Mortensen, Eric M.; Mansi, Ishak] VA North Texas Hlth Care Syst, Dallas, TX USA. [Mortensen, Eric M.; Mansi, Ishak] Univ Texas Southwestern, Div Outcomes & Hlth Serv Res, Dept Med & Clin Sci, Dallas, TX USA. OI Mortensen, Eric/0000-0002-3880-5563 FU NCATS NIH HHS [KL2 TR001118, UL1 TR001120]; NCRR NIH HHS [KL2 RR025766] NR 55 TC 6 Z9 6 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1743-6095 EI 1743-6109 J9 J SEX MED JI J. Sex. Med. PD JAN PY 2015 VL 12 IS 1 BP 158 EP 167 DI 10.1111/jsm.12745 PG 10 WC Urology & Nephrology SC Urology & Nephrology GA CA4CO UT WOS:000348852100018 PM 25421152 ER PT J AU Lee, G Varanasi, CV Liu, J AF Lee, Gyeonghee Varanasi, Chakrapani V. Liu, Jie TI Effects of morphology and chemical doping on electrochemical properties of metal hydroxides in pseudocapacitors SO NANOSCALE LA English DT Article ID ADVANCED ENERGY-CONVERSION; SUPERCAPACITOR ELECTRODES; NICKEL-HYDROXIDE; PERFORMANCE; STORAGE; NANOPARTICLES; GLUCOSE; NANOSTRUCTURE; CONDUCTIVITY; BEHAVIOR AB It is well known that both the structural morphology and chemical doping are important factors that affect the properties of metal hydroxide materials in electrochemical energy storage devices. In this work, an effective method to tailor the morphology and chemical doping of metal hydroxides is developed. It is shown that the morphology and the degree of crystallinity of Ni(OH)(2) can be changed by adding glucose in the ethanol-mediated solvothermal synthesis. Ni(OH)(2) produced in this manner exhibited an increased specific capacitance, which is partially attributed to its increased surface area. Interestingly, the effect of morphology on cobalt doped-Ni(OH)(2) is found to be more effective at low cobalt contents than at high cobalt contents in terms of improving the electrochemical performance. This result reveals the existence of competitive effects between chemical doping and morphology change. These findings will provide important insights to design effective materials for energy storage devices. C1 [Lee, Gyeonghee; Liu, Jie] Duke Univ, Dept Chem, Durham, NC 27708 USA. [Varanasi, Chakrapani V.] Army Res Off, Durham, NC 27703 USA. RP Varanasi, CV (reprint author), Army Res Off, Durham, NC 27703 USA. EM chakrapani.v.varanasi.civ@mail.mil; j.liu@duke.edu RI Liu, Jie/B-4440-2010 OI Liu, Jie/0000-0003-0451-6111 FU Army Research Office (ARO) [W911NF-04-D-0001]; Duke SMIF (Shared Materials Instrumentation Facilities) FX This work was supported by a research grant from Army Research Office (ARO) under contract W911NF-04-D-0001. However, any opinions, findings, conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the ARO. The authors also acknowledge the help of Minhee Lee in NMR analysis and the support from Duke SMIF (Shared Materials Instrumentation Facilities). NR 37 TC 14 Z9 14 U1 7 U2 41 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2040-3364 EI 2040-3372 J9 NANOSCALE JI Nanoscale PY 2015 VL 7 IS 7 BP 3181 EP 3188 DI 10.1039/c4nr06997h PG 8 WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA CB2QQ UT WOS:000349473200044 PM 25615929 ER PT J AU Linkov, I Massey, O Keisler, J Rusyn, I Hartung, T AF Linkov, Igor Massey, Olivia Keisler, Jeff Rusyn, Ivan Hartung, Thomas TI From "Weight of Evidence" to Quantitative Data Integration using Multicriteria Decision Analysis and Bayesian Methods SO ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION LA English DT Article DE weight of evidence; decision analysis; Bayesian; toxicology; policy ID EVIDENCE-BASED TOXICOLOGY; SKIN SENSITIZATION; TESTING STRATEGIES; OSIRIS WEIGHT; THOUGHT; FOOD; NANOMATERIALS; PROBABILITY; ASSESSMENTS; INFORMATION AB "Weighing" available evidence in the process of decision-making is unavoidable, yet it is one step that routinely raises suspicions: what evidence should be used, how much does it weigh, and whose thumb may be tipping the scales? This commentary aims to evaluate the current state and future roles of various types of evidence for hazard assessment as it applies to environmental health. In its recent evaluation of the US Environmental Protection Agency's Integrated Risk Information System assessment process, the National Research Council committee singled out the term "weight of evidence" (WoE) for critique, deeming the process too vague and detractive to the practice of evaluating human health risks of chemicals. Moving the methodology away from qualitative, vague and controversial methods towards generalizable, quantitative and transparent methods for appropriately managing diverse lines of evidence is paramount for both regulatory and public acceptance of the hazard assessments. The choice of terminology notwithstanding, a number of recent Bayesian WoE-based methods, the emergence of multi criteria decision analysis for WoE applications, as well as the general principles behind the foundational concepts of WoE, show promise in how to move forward and regain trust in the data integration step of the assessments. We offer our thoughts on the current state of WoE as a whole and while we acknowledge that many WoE applications have been largely qualitative and subjective in nature, we see this as an opportunity to turn WoE towards a quantitative direction that includes Bayesian and multi criteria decision analysis. C1 [Linkov, Igor; Massey, Olivia] US Army, Engn Res & Dev Ctr, Concord, MA 01742 USA. [Massey, Olivia] MIT, Cambridge, MA 02139 USA. [Keisler, Jeff] Univ Massachusetts, Boston, MA 02125 USA. [Rusyn, Ivan] Texas A&M Univ, College Stn, TX USA. [Hartung, Thomas] Johns Hopkins Bloomberg Sch Publ Hlth, Ctr Alternat Anim Testing, Baltimore, MD USA. [Hartung, Thomas] Univ Konstanz, Ctr Alternat Anim Testing Europe, Constance, Germany. RP Linkov, I (reprint author), US Army, Engn Res & Dev Ctr, Concord, MA 01742 USA. EM Igor.Linkov@usace.army.mil RI Rusyn, Ivan/S-2426-2016 FU USACE Dredging Operations and Environmental Research program FX The authors acknowledge funding from the USACE Dredging Operations and Environmental Research program. The authors thank Dr Todd Bridges as program manager and Mr Matthew Bates for comments and discussions. NR 34 TC 11 Z9 11 U1 0 U2 9 PU SPEKTRUM AKADEMISCHER VERLAG-SPRINGER-VERLAG GMBH PI HEILDEBERG PA TIERGARTENSTRASSE 17, HEILDEBERG, 69121, GERMANY SN 1868-596X EI 1868-8551 J9 ALTEX-ALTERN ANIM EX JI ALTEX-Altern. Anim. Exp. PY 2015 VL 32 IS 1 BP 3 EP 8 PG 6 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA CA5QM UT WOS:000348962900002 PM 25592482 ER PT S AU Kim, JH Excler, JL Michael, NL AF Kim, Jerome H. Excler, Jean-Louis Michael, Nelson L. BE Caskey, CT TI Lessons from the RV144 Thai Phase III HIV-1 Vaccine Trial and the Search for Correlates of Protection SO ANNUAL REVIEW OF MEDICINE, VOL 66 SE Annual Review of Medicine LA English DT Review; Book Chapter DE efficacy; correlates of risk; nonneutralizing antibody; neutralizing antibody; antibody-dependent cytotoxicity; envelope; HIV vaccine ID HUMAN-IMMUNODEFICIENCY-VIRUS; BROADLY NEUTRALIZING ANTIBODIES; RECOMBINANT GLYCOPROTEIN-120 VACCINE; CELL-MEDIATED-IMMUNITY; EFFICACY TRIAL; RHESUS-MONKEYS; DOUBLE-BLIND; GAG/POL/NEF VACCINE; ALVAC-HIV; ANTIRETROVIRAL PROPHYLAXIS AB RV144 remains the only HIV-1 vaccine trial to demonstrate efficacy against HIV-1 acquisition. The prespecified analysis of immune correlates of risk showed that antibodies directed against the V1V2 region of gp120, in particular the IgG1 and IgG3 subclass mediating antibody-dependent cell-mediated cytotoxicity, seem to play a predominant role in protection against HIV-1 acquisition and that plasma envelope (Env)-specific IgA antibodies were directly correlated with risk. RV144 and recent nonhuman primate challenge studies suggest that Env is essential, and perhaps sufficient, to induce protective antibody responses against mucosal HIV-1 acquisition. Follow-up clinical trials are ongoing to further dissect the immune responses elicited by the RV144 ALVAC-HIV and AIDSVAXR (R) B/E regimen. The study of gp120 Env immunogens and immune correlates of risk has resulted in the development of improved antigens. Whether the RV144 immune correlates of risk will generalize to other populations vaccinated with similar immunogens with different modes and intensity of transmission remains to be demonstrated. Efficacy trials are now planned in heterosexual populations in southern Africa and men who have sex with men in Thailand. C1 [Kim, Jerome H.; Excler, Jean-Louis; Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Excler, Jean-Louis] Henry M Jackson Fdn, US Mil HIV Res Program, Bethesda, MD 20817 USA. RP Kim, JH (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. EM jkim@hivresearch.org; jexcler@hivresearch.org; nmichael@hivresearch.org FU NIAID NIH HHS [Y1-AI-2642-12] NR 96 TC 26 Z9 26 U1 2 U2 19 PU ANNUAL REVIEWS PI PALO ALTO PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA SN 0066-4219 BN 978-0-8243-0566-6 J9 ANNU REV MED JI Annu. Rev. Med. PY 2015 VL 66 BP 423 EP 437 DI 10.1146/annurev-med-052912-123749 PG 15 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA BB9PT UT WOS:000348560300028 PM 25341006 ER PT J AU Singh, B Crippen, T Zheng, LY Fields, AT Yu, ZN Ma, Q Wood, TK Dowd, SE Flores, M Tomberlin, JK Tarone, AM AF Singh, Baneshwar Crippen, Tawni L. Zheng, Longyu Fields, Andrew T. Yu, Ziniu Ma, Qun Wood, Thomas K. Dowd, Scot E. Flores, Micah Tomberlin, Jeffery K. Tarone, Aaron M. TI A metagenomic assessment of the bacteria associated with Lucilia sericata and Lucilia cuprina (Diptera: Calliphoridae) SO APPLIED MICROBIOLOGY AND BIOTECHNOLOGY LA English DT Article DE Microbial community; Blow flies; Maggot debridement therapy; Salivary gland; 454 sequencing ID RIBOSOMAL-RNA SEQUENCES; MAGGOT THERAPY; FLIES DIPTERA; STAPHYLOCOCCUS-AUREUS; ANTIBIOTIC-RESISTANT; FORENSIC ENTOMOLOGY; MAXIMUM-LIKELIHOOD; BIOFILM FORMATION; DIGESTIVE-TRACT; MUSCA-DOMESTICA AB Lucilia Robineau-Desvoidy (Diptera: Calliphoridae) is a blow fly genus of forensic, medical, veterinary, and agricultural importance. This genus is also famous because of its beneficial uses in maggot debridement therapy (MDT). Although the genus is of considerable economic importance, our knowledge about microbes associated with these flies and how these bacteria are horizontally and trans-generationally transmitted is limited. In this study, we characterized bacteria associated with different life stages of Lucilia sericata (Meigen) and Lucilia cuprina (Wiedemann) and in the salivary gland of L. sericata by using 16S rDNA 454 pyrosequencing. Bacteria associated with the salivary gland of L. sericata were also characterized using light and transmission electron microscopy (TEM). Results from this study suggest that the majority of bacteria associated with these flies belong to phyla Proteobacteria, Firmicutes, and Bacteroidetes, and most bacteria are maintained intragenerationally, with a considerable degree of turnover from generation to generation. In both species, second-generation eggs exhibited the highest bacterial phylum diversity (20 % genetic distance) than other life stages. The Lucilia sister species shared the majority of their classified genera. Of the shared bacterial genera, Providencia, Ignatzschineria, Lactobacillus, Lactococcus, Vagococcus, Morganella, and Myroides were present at relatively high abundances. Lactobacillus, Proteus, Diaphorobacter, and Morganella were the dominant bacterial genera associated with a survey of the salivary gland of L. sericata. TEM analysis showed a sparse distribution of both Gram-positive and Gram-negative bacteria in the salivary gland of L. sericata. There was more evidence for horizontal transmission of bacteria than there was for trans-generational inheritance. Several pathogenic genera were either amplified or reduced by the larval feeding on decomposing liver as a resource. Overall, this study provides information on bacterial communities associated with different life stages of Lucilia and their horizontal and trans-generational transmission, which may help in the development of better vector-borne disease management and MDT methods. C1 [Singh, Baneshwar; Zheng, Longyu; Fields, Andrew T.; Flores, Micah; Tomberlin, Jeffery K.; Tarone, Aaron M.] Texas A&M Univ, Dept Entomol, College Stn, TX 77843 USA. [Singh, Baneshwar] Virginia Commonwealth Univ, Dept Forens Sci, Richmond, VA 23284 USA. [Crippen, Tawni L.; Zheng, Longyu] ARS, Southern Plains Agr Res Ctr, USDA, College Stn, TX USA. [Zheng, Longyu; Yu, Ziniu] Huazhong Agr Univ, Natl Engn Res Ctr Microbe Pesticide, State Key Lab Agr Microbiol, Wuhan, Peoples R China. [Fields, Andrew T.] SUNY Stony Brook, Sch Marine & Atmospher Sci, Stony Brook, NY 11794 USA. [Ma, Qun] Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Tianjin, Peoples R China. [Wood, Thomas K.] Penn State Univ, Dept Chem Engn, University Pk, PA 16802 USA. [Dowd, Scot E.] MR DNA Mol Res LP, Shallowater, TX USA. [Flores, Micah] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Singh, B (reprint author), Virginia Commonwealth Univ, Dept Forens Sci, 1015 Floyd Ave, Richmond, VA 23284 USA. EM bsingh@vcu.edu OI Tarone, Aaron/0000-0003-0965-7634; Wood, Thomas/0000-0002-6258-529X FU Texas Agrilife Research; College of Agriculture and Life Sciences at Texas A&M University, College Station, TX; National Institute of Justice, Office of Justice Programs, U.S. Department of Justice [2010-DN-BX-K243]; College of Humanities and Sciences of Virginia Commonwealth University, Richmond, VA FX The authors would like to thank Dr. Robert Droleskey for his assistance with transmission electron microscopy of the salivary gland. Funding for B.S., A.M.T., L.Z., A.T.F., M.F., and J.K.T. was provided partially by the Texas Agrilife Research and the College of Agriculture and Life Sciences at Texas A&M University, College Station, TX. Additional funding for B.S., A.M.T., T.L.C., and J.K.T. was provided by the National Institute of Justice, Office of Justice Programs, U.S. Department of Justice through Grant 2010-DN-BX-K243. B.S. was also supported by a start up fund from the College of Humanities and Sciences of Virginia Commonwealth University, Richmond, VA. We also thank anonymous reviewers for their suggestions that improved this article substantially. Points of view in this document are those of the authors and do not necessarily represent the official position or policies of the U.S. Department of Justice, Department of the Army, Department of Defense, or U.S. Government. Mention of trade names, companies, or commercial products in this publication is solely for the purpose of providing specific information and does not imply recommendation or endorsement of the products by the U.S. Department of Agriculture. NR 85 TC 12 Z9 12 U1 7 U2 33 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0175-7598 EI 1432-0614 J9 APPL MICROBIOL BIOT JI Appl. Microbiol. Biotechnol. PD JAN PY 2015 VL 99 IS 2 BP 869 EP 883 DI 10.1007/s00253-014-6115-7 PG 15 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA CA2YB UT WOS:000348770900027 PM 25306907 ER PT J AU Cesur, R Sabia, JJ Tekin, E AF Cesur, Resul Sabia, Joseph J. Tekin, Erdal TI Combat exposure and migraine headache: Evidence from exogenous deployment assignment SO ECONOMICS & HUMAN BIOLOGY LA English DT Article DE Migraine headache; Combat exposure; Sleep disruption ID TRAUMATIC BRAIN-INJURY; MILITARY SERVICE; UNITED-STATES; EDUCATIONAL-ATTAINMENT; HEALTH; IMPACT; PREVALENCE; VETERANS; BURDEN; EPIDEMIOLOGY AB Migraine headache is a growing problem for U.S. servicemembers deployed to Iraq and Afghanistan and has been linked to substantial negative socioeconomic consequences. However, there has been no comprehensive examination of the relationship between combat exposure and migraine headache or its stress-related triggers. Analyzing data drawn from the National Longitudinal Study of Adolescent Health, we use exogenous variation in deployment assignment to estimate the effect of combat exposure on migraine headache. We find that those deployed to a combat zone with enemy firefight are at substantially increased risk for migraine headache relative to those deployed to non-combat zones outside the United States or to combat zones without enemy firefight. We find that combat-induced sleep disorders, stress-related psychological problems, and physical injuries in combat explain approximately 40-45 percent of the relationship between combat exposure and migraine headache. (C) 2014 Published by Elsevier B.V. C1 [Cesur, Resul] Univ Connecticut, Dept Finance, Sch Business, Storrs, CT 06269 USA. [Sabia, Joseph J.] San Diego State Univ, San Diego, CA 92182 USA. [Sabia, Joseph J.] US Mil Acad, Dept Econ, San Diego, CA 92182 USA. [Tekin, Erdal] Georgia State Univ, IZA, Atlanta, GA 30303 USA. RP Sabia, JJ (reprint author), San Diego State Univ, 5500 Campanile Dr, San Diego, CA 92182 USA. EM cesur@business.uconn.edu; jsabia@mail.sdsu.edu; tekin@gsu.edu NR 46 TC 2 Z9 2 U1 1 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1570-677X EI 1873-6130 J9 ECON HUM BIOL JI Econ. Hum. Biol. PD JAN PY 2015 VL 16 BP 81 EP 99 DI 10.1016/j.ehb.2014.01.001 PG 19 WC Economics; Public, Environmental & Occupational Health SC Business & Economics; Public, Environmental & Occupational Health GA CA5OW UT WOS:000348958700007 PM 24560382 ER PT J AU Newman, AJ Clark, MP Sampson, K Wood, A Hay, LE Bock, A Viger, RJ Blodgett, D Brekke, L Arnold, JR Hopson, T Duan, Q AF Newman, A. J. Clark, M. P. Sampson, K. Wood, A. Hay, L. E. Bock, A. Viger, R. J. Blodgett, D. Brekke, L. Arnold, J. R. Hopson, T. Duan, Q. TI Development of a large-sample watershed-scale hydrometeorological data set for the contiguous USA: data set characteristics and assessment of regional variability in hydrologic model performance SO HYDROLOGY AND EARTH SYSTEM SCIENCES LA English DT Article ID RAINFALL-RUNOFF MODELS; CONTERMINOUS UNITED-STATES; DAILY SOLAR-RADIATION; LAND-SURFACE FLUXES; PARAMETER-ESTIMATION; GLOBAL OPTIMIZATION; QUALITY-ASSURANCE; TEMPERATURE DATA; COMPLEX TERRAIN; PRECIPITATION AB We present a community data set of daily forcing and hydrologic response data for 671 small- to medium-sized basins across the contiguous United States (median basin size of 336 km(2)) that spans a very wide range of hydroclimatic conditions. Area-averaged forcing data for the period 1980-2010 was generated for three basin spatial configurations - basin mean, hydrologic response units (HRUs) and elevation bands - by mapping daily, gridded meteorological data sets to the subbasin (Daymet) and basin polygons (Daymet, Maurer and NLDAS). Daily streamflow data was compiled from the United States Geological Survey National Water Information System. The focus of this paper is to (1) present the data set for community use and (2) provide a model performance benchmark using the coupled Snow-17 snow model and the Sacramento Soil Moisture Accounting Model, calibrated using the shuffled complex evolution global optimization routine. After optimization minimizing daily root mean squared error, 90% of the basins have Nash-Sutcliffe efficiency scores >= 0.55 for the calibration period and 34% >= 0.8. This benchmark provides a reference level of hydrologic model performance for a commonly used model and calibration system, and highlights some regional variations in model performance. For example, basins with a more pronounced seasonal cycle generally have a negative low flow bias, while basins with a smaller seasonal cycle have a positive low flow bias. Finally, we find that data points with extreme error (defined as individual days with a high fraction of total error) are more common in arid basins with limited snow and, for a given aridity, fewer extreme error days are present as the basin snow water equivalent increases. C1 [Newman, A. J.; Clark, M. P.; Sampson, K.; Wood, A.; Hopson, T.] Natl Ctr Atmospher Res, Boulder, CO 80307 USA. [Hay, L. E.; Bock, A.; Viger, R. J.] US Geol Survey, Lakewood, CO 80225 USA. [Blodgett, D.] US Geol Survey, Ctr Integrated Data Analyt, Middleton, WI USA. [Brekke, L.] US Dept Interior, Bur Reclamat, Denver, CO USA. [Arnold, J. R.] US Army Corps Engineers, Inst Water Resources, Seattle, WA USA. [Duan, Q.] Beijing Normal Univ, Beijing 100875, Peoples R China. RP Newman, AJ (reprint author), Natl Ctr Atmospher Res, POB 3000, Boulder, CO 80307 USA. EM anewman@ucar.edu RI Clark, Martyn/A-5560-2015; Duan, Qingyun/C-7652-2011 OI Clark, Martyn/0000-0002-2186-2625; Duan, Qingyun/0000-0001-9955-1512 FU US Army Corps of Engineers Climate Preparedness and Resilience Programs; US Department of the Interior Bureau of Reclamation FX This work is funded by the US Army Corps of Engineers Climate Preparedness and Resilience Programs and the US Department of the Interior Bureau of Reclamation. The authors would like to thank the USGS Modeling of Watershed Systems (MoWS) group, specifically for providing technical support and the national geospatial fabric data to generate all the basin spatial configurations. We would also like to thank Jordan Read and Tom Kunicki of the USGS Center for Integrated Data Analytics for their help with the USGS Geodata Portal. NR 80 TC 16 Z9 16 U1 1 U2 14 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY SN 1027-5606 EI 1607-7938 J9 HYDROL EARTH SYST SC JI Hydrol. Earth Syst. Sci. PY 2015 VL 19 IS 1 BP 209 EP 223 DI 10.5194/hess-19-209-2015 PG 15 WC Geosciences, Multidisciplinary; Water Resources SC Geology; Water Resources GA CA5EA UT WOS:000348929800012 ER PT J AU Rafaels, KA Cutcliffe, HC Salzar, RS Davis, M Boggess, B Bush, B Harris, R Rountree, MS Sanderson, E Campman, S Koch, S Bass, CR AF Rafaels, Karin A. Cutcliffe, Hattie C. Salzar, Robert S. Davis, Martin Boggess, Brian Bush, Bryan Harris, Robert Rountree, Mark Steve Sanderson, Ellory Campman, Steven Koch, Spencer Bass, Cameron R. Dale TI Injuries of the Head from Backface Deformation of Ballistic Protective Helmets Under Ballistic Impact SO JOURNAL OF FORENSIC SCIENCES LA English DT Article DE forensic science; head injury; ballistic injury; biomechanics; helmet deformation; backface deformation ID AGE-RELATED-CHANGES; CORTICAL BONE; RELATIVE IMPORTANCE; TENSILE-STRENGTH; DENSITY; ARMY AB Modern ballistic helmets defeat penetrating bullets by energy transfer from the projectile to the helmet, producing helmet deformation. This deformation may cause severe injuries without completely perforating the helmet, termed behind armor blunt trauma (BABT). As helmets become lighter, the likelihood of larger helmet backface deformation under ballistic impact increases. To characterize the potential for BABT, seven postmortem human head/neck specimens wearing a ballistic protective helmet were exposed to nonperforating impact, using a 9mm, full metal jacket, 124 grain bullet with velocities of 400-460m/s. An increasing trend of injury severity was observed, ranging from simple linear fractures to combinations of linear and depressed fractures. Overall, the ability to identify skull fractures resulting from BABT can be used in forensic investigations. Our results demonstrate a high risk of skull fracture due to BABT and necessitate the prevention of BABT as a design factor in future generations of protective gear. C1 [Rafaels, Karin A.; Salzar, Robert S.; Davis, Martin; Boggess, Brian; Bush, Bryan] Univ Virginia, Ctr Appl Biomech, Charlottesville, VA 22911 USA. [Cutcliffe, Hattie C.; Bass, Cameron R. Dale] Duke Univ, Injury Biomech Lab, Dept Biomed Engn, Durham, NC 27708 USA. [Harris, Robert] Emory Univ, Atlanta, GA 30329 USA. [Rountree, Mark Steve] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD 20723 USA. [Sanderson, Ellory] US Army, Aberdeen Test Ctr, CSTE DTC AT CS BD, Aberdeen Proving Ground, MD 21005 USA. [Campman, Steven] San Diego Cty Med Examiners Off, San Diego, CA 92123 USA. [Koch, Spencer] Duke Univ, Med Ctr, Dept Radiol, Durham, NC 27710 USA. RP Cutcliffe, HC (reprint author), Duke Univ, Injury Biomech Lab, Dept Biomed Engn, 136 Hudson Hall,Box 90281, Durham, NC 27708 USA. EM hattie.cutcliffe@duke.edu FU Natick Soldier Center; Armed Forces Institute of Pathology; Uniformed Services University of the Health Sciences; Walter Reed Army Medical Center FX Support provided by the Natick Soldier Center, The Armed Forces Institute of Pathology, The Uniformed Services University of the Health Sciences and Mr. George Holborow, and the Walter Reed Army Medical Center. NR 20 TC 4 Z9 5 U1 3 U2 18 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-1198 EI 1556-4029 J9 J FORENSIC SCI JI J. Forensic Sci. PD JAN PY 2015 VL 60 IS 1 BP 219 EP 225 DI 10.1111/1556-4029.12570 PG 7 WC Medicine, Legal SC Legal Medicine GA AZ8AR UT WOS:000348437700033 PM 25039407 ER PT J AU Chapman, DP Liu, Y McKnight-Eily, LR Croft, JB Holt, JB Balkin, TJ Giles, WH AF Chapman, Daniel P. Liu, Yong McKnight-Eily, Lela R. Croft, Janet B. Holt, James B. Balkin, Thomas J. Giles, Wayne H. TI Daily Insufficient Sleep and Active Duty Status SO MILITARY MEDICINE LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; U.S. MILITARY VETERANS; SERVICE MEMBERS; US ADULTS; COMBAT; PERSONNEL; SYMPTOMS; ASSOCIATION; DEPLOYMENT; BEHAVIORS AB Objective: We assessed the relationship between active duty status and daily insufficient sleep in a telephone survey. Methods: U.S. military service status (recent defined as past 12 months and past defined as >12 months ago) and daily insufficient sleep in the past 30 days were assessed among 566,861 adults aged 18 to 64 years and 271,202 adults aged >= 65 years in the 2009 to 2010 Behavioral Risk Factor Surveillance System surveys. Results: Among ages 18 to 64 years, 1.1% reported recent active duty and 7.1% had past service; among ages >= 65 years, 0.6% reported recent and 24.6% had past service. Among ages 18 to 64 years, prevalence of daily insufficient sleep was 13.7% among those reporting recent duty, 12.6% for those with past service, and 11.2% for those with no service. Insufficient sleep did not vary significantly with active duty status among ages >= 65 years. After adjustment for sociodemographic characteristics, health behaviors, and frequent mental distress in multivariate logistic regression models, respondents aged 18 to 64 years with recent active duty were 34% more likely and those with past service were 23% more likely to report daily insufficient sleep than those with no service (p < 0.05, both). Conclusions: Adults with either recent or past active duty have a greater risk for daily insufficient sleep. C1 [Chapman, Daniel P.; Liu, Yong; McKnight-Eily, Lela R.; Croft, Janet B.; Holt, James B.; Giles, Wayne H.] Natl Ctr Chron Dis Prevent & Hlth Promot, Ctr Dis Control & Prevent, Div Populat Hlth, Epidemiol & Surveillance Branch, Atlanta, GA 30341 USA. [Balkin, Thomas J.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Dept Behav Biol, Silver Spring, MD 20910 USA. RP Chapman, DP (reprint author), Natl Ctr Chron Dis Prevent & Hlth Promot, Ctr Dis Control & Prevent, Div Populat Hlth, Epidemiol & Surveillance Branch, 4770 Buford Highway Northeast,Mailstop K-78, Atlanta, GA 30341 USA. NR 39 TC 0 Z9 0 U1 1 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JAN PY 2015 VL 180 IS 1 BP 68 EP 76 DI 10.7205/MILMED-D-14-00158 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA CA7MM UT WOS:000349101400028 PM 25562860 ER PT J AU Hill, SW AF Hill, Steven W. TI US Army Hospital Ship "Relief" SO MILITARY MEDICINE LA English DT Editorial Material C1 Natl Museum Hlth & Med, US Army Med Res & Mat Command, Silver Spring, MD 20910 USA. RP Hill, SW (reprint author), Natl Museum Hlth & Med, US Army Med Res & Mat Command, 2500 Linden Lane, Silver Spring, MD 20910 USA. NR 2 TC 1 Z9 1 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JAN PY 2015 VL 180 IS 1 BP 118 EP 118 DI 10.7205/MILMED-D-14-00458 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA CA7MM UT WOS:000349101400035 PM 25562867 ER PT J AU Bateman, JA Chang, A Capo-Aponte, J AF Bateman, Jennifer A. Chang, Amy Capo-Aponte, Jose TI Cerebellar Ischemia Manifesting As Vertical Diplopia: A Case Study on Skew Deviation SO MILITARY MEDICINE LA English DT Article ID VERTEBRAL ARTERY DISSECTION; CHIROPRACTIC MANIPULATION; RISK-FACTOR; STROKE; DIFFERENTIATE AB Purpose: Skew deviation mimics superior oblique palsy. Associated findings can include ocular torsion, head tilt, headache, and neurologic symptoms that may help localize the responsible intracranial lesion. Accurate diagnosis is essential in determining and treating the underlying cause. Imaging options will be reviewed. Case Report: A 29-year-old white male presented to the emergency room with sudden onset vertical diplopia after self-neck manipulation. An ophthalmic evaluation led to the diagnosis of skew deviation. Diagnostic imaging revealed an infarct of the cerebellum likely secondary to a vertebral artery dissection. Besides neck manipulation, other possible contributing factors include smoking, elevated cholesterol, and elevated testosterone. Symptoms resolved within 24 hours and the patient was treated with aspirin and atorvastatin calcium. Conclusions: Skew deviation must be a consideration in patients with vertical diplopia, and ruled out before a superior oblique palsy diagnosis. Vertebral artery dissections are uncommon in the general population but can account for up to 25% of ischemic strokes in the young and middle-aged. Smoking, high cholesterol, and high testosterone are known risk factors of stroke. Research is inconclusive on spinal manipulation's relation to stroke. This report presents an example of neck manipulation directly preceding skew deviation secondary to stroke. C1 [Bateman, Jennifer A.; Chang, Amy; Capo-Aponte, Jose] Womack Army Med Ctr, Dept Optometry, Ft Bragg, NC 28310 USA. RP Bateman, JA (reprint author), Womack Army Med Ctr, Dept Optometry, 2817 Reilly Rd, Ft Bragg, NC 28310 USA. NR 24 TC 0 Z9 0 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JAN PY 2015 VL 180 IS 1 BP E168 EP E173 DI 10.7205/MILMED-D-14-00292 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA CA7MM UT WOS:000349101400013 PM 25562880 ER PT J AU Freeman, R Lenz, B AF Freeman, Randall Lenz, Brittany TI Cutaneous Reactions Associated With ACAM2000 Smallpox Vaccination in a Deploying US Army Unit SO MILITARY MEDICINE LA English DT Article ID ADVERSE EVENTS; VACCINIA; STATES AB Since 2003, the U. S. Army has vaccinated deploying troops for smallpox. In 2008, the U. S. military transitioned to the second-generation vaccine ACAM2000. Cutaneous adverse events associated with this vaccine are rarely characterized. We review the medical literature on cutaneous adverse events with ACAM2000 and describe four new cases that occurred in primary vaccinees at Fort Wainwright, Alaska. Four cases of disseminated papulovesicular lesions occurred out of 500 smallpox vaccinations given at Fort Wainwright, Alaska. Each case was followed by dermatology and preventive medicine. Biopsy specimens were examined at Walter Reed Army Medical Center and the U. S. Centers for Disease Control and Prevention. Three of the cases had variable clinical history of dermatitis. Case 1 experienced the most extensive lesions and case duration, and Case 4 the least. All biopsy sample results confirmed immune-mediated hypersensitivity. This study relied on self-reporting and on surveillance by unit medical staff to identify cases. Each case also received multiple other concurrent vaccinations. Further study is needed to increase our knowledge of these cutaneous reactions and demonstrate possible associated or causal factors. C1 [Freeman, Randall] US Army, ATTN AHRC SG, Human Resources Command, Fort Knox, KY 40122 USA. [Lenz, Brittany] 22nd Med Grp, McConnell AFB, KS 67221 USA. RP Freeman, R (reprint author), US Army, ATTN AHRC SG, Human Resources Command, 1600 Spearhead Div Ave, Fort Knox, KY 40122 USA. NR 15 TC 0 Z9 0 U1 0 U2 6 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JAN PY 2015 VL 180 IS 1 BP E152 EP E156 DI 10.7205/MILMED-D-14-00218 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA CA7MM UT WOS:000349101400009 PM 25562876 ER PT J AU Gee, S Dunn, J Waterman, B Todd, M AF Gee, Shawn Dunn, John Waterman, Brian Todd, Michael TI Orthobiological Augmentation of Consecutive Rotator Cuff Repair Failure and Deltoid Dehiscence SO MILITARY MEDICINE LA English DT Article ID MEDIAL COLLATERAL LIGAMENT; SMALL-INTESTINAL SUBMUCOSA; SURGICAL REPAIR; DETACHMENT; TEARS AB We present a case of postsurgical deltoid insufficiency occurring after augmented revision of a failed prior rotator cuff repair. Revision deltoid repair with deltoid imbrication and orthobiological augmentation was dually performed, resulting in successful deltoid and rotator cuff healing and improved clinical outcomes. C1 [Gee, Shawn] Tripler Army Med Ctr, Dept Orthopaed Surg, Honolulu, HI 96819 USA. [Dunn, John; Waterman, Brian; Todd, Michael] William Beaumont Army Med Ctr, Dept Orthopaed Surg, El Paso, TX 79920 USA. RP Gee, S (reprint author), Tripler Army Med Ctr, Dept Orthopaed Surg, 459 Patterson Rd, Honolulu, HI 96819 USA. NR 13 TC 0 Z9 0 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JAN PY 2015 VL 180 IS 1 BP E142 EP E144 DI 10.7205/MILMED-D-14-00251 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA CA7MM UT WOS:000349101400006 PM 25562873 ER PT J AU Ore, MRM Lynch, D Rumsey, C AF Ore, Maj Robert M. Lynch, David Rumsey, Christopher TI Uterine Arteriovenous Malformation, Images, and Management SO MILITARY MEDICINE LA English DT Article ID UTERUS AB Background: Uterine arteriovenous malformation (AVM) is an infrequently described cause of severe genital tract bleeding. This is an important diagnostic consideration as therapeutic options differ significantly from those utilized with alternate etiologies of genital tract bleeding. Case: A 30-year-old multiparous female presented initially with vaginal bleeding, and subsequently with intra-abdominal hemorrhage. She was diagnosed with uterine AVM, and was managed with uterine artery embolization followed by eventual hysterectomy. Conclusion: AVMs, both congenital and acquired, are diagnosed utilizing a range of radiographic tools. Management modalities include embolization and hysterectomy. Our patient presented uniquely with intra-abdominal hemorrhage. Previously managed with uterine artery embolization, hysterectomy became necessary because of her clinical presentation. C1 [Ore, Maj Robert M.] David Grant Med Ctr, Womens Hlth Clin, Travis AFB, CA 94535 USA. [Lynch, David] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Rumsey, Christopher] OB GYN, Ft Drum, Watertown, NY 13601 USA. RP Ore, MRM (reprint author), David Grant Med Ctr, Womens Hlth Clin, 101 Bodin Circle, Travis AFB, CA 94535 USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JAN PY 2015 VL 180 IS 1 BP E177 EP E180 DI 10.7205/MILMED-D-14-00145 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA CA7MM UT WOS:000349101400015 ER PT J AU Pritchett, TM Ferry, MJ Mott, AG Shensky, W Haley, JE Liu, R Sun, WF AF Pritchett, Timothy M. Ferry, Michael J. Mott, Andrew G. Shensky, William, III Haley, Joy E. Liu, Rui Sun, Wenfang TI Long-lifetime reverse saturable absorption in a bipyridyl platinum(II) complex bearing naphthalimidylethynyl-substituted fluorenylacetylide ligands SO OPTICAL MATERIALS LA English DT Article DE Z scan; Reverse saturable absorption ID EXCITED-STATE ABSORPTION; DIIMINE BIS(ACETYLIDE) COMPLEXES; TOP-HAT BEAMS; NONLINEAR ABSORPTION; ACETYLIDE COMPLEXES; PHOTOPHYSICS; PHOSPHORESCENCE; LUMINESCENCE; OXYGEN AB By fitting femtosecond transient difference absorption time series at multiple wavelengths, the singlet excited-state lifetime of a particular platinum(II) 2,2'-bipyridyl complex bearing naphthalimidylethynyl-substituted fluorenyl-acetylide ligands was determined to be 83.5 +/- 39 ps in toluene solution. A triplet quantum yield of 0.06 was measured using relative actinometry. Excited-state absorption cross sections of 5.6 x 10(-17) cm(2) (singlet) and 7.8 x 10(-16) cm(2) (triplet) at 532 nm were obtained by using a five-level dynamic model to fit open-aperture Z scans at picosecond and nanosecond pulse widths and a variety of pulse energies. Most significantly, fits of nanosecond transient difference absorption decay data yield a value of 16.3 ps for the triplet excited-state lifetime of the complex in deoxygenated toluene solution, longer by a factor of almost 20 than the lifetime of the analogous complex with benzothiazolyl-substituted ligands. Published by Elsevier B.V. C1 [Pritchett, Timothy M.; Ferry, Michael J.; Mott, Andrew G.; Shensky, William, III] US Army, Res Lab, Attn RDRL SEE L, Adelphi, MD 20783 USA. [Haley, Joy E.] Air Force Res Lab, Mat & Mfg Directorate, Wright Patterson AFB, OH 45433 USA. [Liu, Rui; Sun, Wenfang] N Dakota State Univ, Dept Chem & Biochem, Fargo, ND 58108 USA. RP Pritchett, TM (reprint author), US Army, Res Lab, Attn RDRL SEE L, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM timothy.m.pritchett.civ@mail.mil NR 26 TC 6 Z9 6 U1 3 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0925-3467 EI 1873-1252 J9 OPT MATER JI Opt. Mater. PD JAN PY 2015 VL 39 BP 195 EP 198 DI 10.1016/j.optmat.2014.11.025 PG 4 WC Materials Science, Multidisciplinary; Optics SC Materials Science; Optics GA CA2OQ UT WOS:000348747900033 ER PT S AU Gunnarsson, CA Love, B Moy, P Weerasooriya, T AF Gunnarsson, C. Allan Love, Bryan Moy, Paul Weerasooriya, Tusit BE Jin, H Sciammarella, C Yoshida, S Lamberti, L TI Tensile Response and the Associated Post: Yield Heating of Polycarbonate SO ADVANCEMENT OF OPTICAL METHODS IN EXPERIMENTAL MECHANICS, VOL 3 SE Conference Proceedings of the Society for Experimental Mechanics Series LA English DT Proceedings Paper CT SEM Annual Conference and Exposition on Experimental and Applied Mechanics CY JUN 02-05, 2014 CL Greenville, SC SP Soc Expt Mech DE DIC; Thermal response; Polycarbonate; Strain rate effect; Post yield behavior AB It is well known that amorphous polymers, such as polycarbonate (PC), will exhibit adiabatic heating due to the large plastic work that occurs when undergoing significant plastic deformation. However the extent of adiabatic heating has not been investigated with respect to strain rate, with full-field temperature measurements performed on the specimen during deformation. In this study, ASTM tensile dog bone PC specimens were used to investigate the rate-dependent mechanical response from quasi-static to intermediate (similar to 10 s(-1)) strain rates using a traditional servo-hydraulic load frame. To determine the variations in yield and post-yield response at different locations of the gage area of the specimen, digital image correlation was used to measure the full-field surface strains. In addition, an InSb thermal camera was used concurrently to measure the full-field temperature distribution in the gage area during the deformation. The material experienced non-uniform heating as high as 50-70 degrees C, and showed significant rate sensitive mechanical response. In this paper, the experimental techniques and results are discussed. C1 [Gunnarsson, C. Allan; Love, Bryan; Moy, Paul; Weerasooriya, Tusit] Army Res Lab, Adelphi, MD 20783 USA. RP Gunnarsson, CA (reprint author), Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM carey.a.gunnarsson.civ@mail.mil NR 6 TC 0 Z9 0 U1 1 U2 2 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 2191-5644 BN 978-3-319-06985-2 J9 C PROC SOC EXP MECH PY 2015 BP 399 EP 401 DI 10.1007/978-3-319-06986-9_48 PG 3 WC Optics; Physics, Applied SC Optics; Physics GA BB8XF UT WOS:000347773500048 ER PT J AU Wolf, TJ Chuh, A Floyd, T McInnis, K Williams, E AF Wolf, Timothy J. Chuh, Adrianna Floyd, Tracy McInnis, Karen Williams, Elizabeth TI Effectiveness of Occupation-Based Interventions to Improve Areas of Occupation and Social Participation After Stroke: An Evidence-Based Review SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY LA English DT Review DE activities of daily living; evaluation studies as topic; human activities; social participation; stroke ID RANDOMIZED CONTROLLED-TRIAL; SELF-CARE INTERVENTION; REHABILITATION PROGRAM; THERAPY INTERVENTION; CLINICAL-TRIAL; COMMUNITY; EDUCATION; SKILLS; PERFORMANCE; SURVIVORS AB This evidence-based review examined the evidence supporting the use of occupation-based interventions to improve areas of occupation and social participation poststroke. A total of 39 studies met the inclusion criteria and were critically evaluated. Most of the literature targeted activity of daily living (ADL)-based interventions and collectively provided strong evidence for the use of occupation-based interventions to improve ADL performance. The evidence related to instrumental ADLs was much more disparate, with limited evidence to support the use of virtual reality interventions and emerging evidence to support driver education programs to improve occupational performance poststroke. Only 6 studies addressed leisure, social participation, or rest and sleep, with sufficient evidence to support only leisure-based interventions. The implications of this review for research, education, and practice in occupational therapy are also discussed. C1 [Wolf, Timothy J.; Chuh, Adrianna; McInnis, Karen; Williams, Elizabeth] Washington Univ, Sch Med, Program Occupat Therapy, St Louis, MO 63130 USA. [Wolf, Timothy J.] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA. [Floyd, Tracy] US Army, Ft Belvoir, VA USA. RP Wolf, TJ (reprint author), Washington Univ, Sch Med, Program Occupat Therapy, St Louis, MO 63130 USA. EM wolft@wustl.edu OI Wolf, Timothy/0000-0003-3607-9454 FU National Center for Medical Rehabilitation Research [K23HD073190] FX We thank Deborah Lieberman and Marian Arbesman for their support and guidance in completing this evidence-based review. Timothy Wolf received salary support to complete this study from the National Center for Medical Rehabilitation Research (Award No. K23HD073190). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. NR 49 TC 2 Z9 2 U1 11 U2 22 PU AMER OCCUPATIONAL THERAPY ASSOC, INC PI BETHESDA PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA SN 0272-9490 EI 1943-7676 J9 AM J OCCUP THER JI Am. J. Occup. Ther. PD JAN-FEB PY 2015 VL 69 IS 1 BP 58 EP 68 DI 10.5014/ajot.2015.012195 PG 11 WC Rehabilitation SC Rehabilitation GA AZ8TT UT WOS:000348488100009 ER PT J AU Ewers, EC Dennison, DH Stagliano, DR AF Ewers, Evan C. Dennison, David H. Stagliano, David R. TI A Unique Case of Adolescent Neuroborreliosis Presenting With Multiple Cranial Neuritis and Cochlear Inflammation on Magnetic Resonance Imaging SO PEDIATRIC NEUROLOGY LA English DT Article DE Lyme disease; neuroborreliosis; hearing loss; Bannwarth syndrome; cochleitis ID LYME-DISEASE; HEARING-LOSS; MANIFESTATIONS; MENINGITIS AB BACKGROUND: Lyme disease is the most common vector-borne disease in the United States and is caused by infection with the spirochete Borrelia burgdorferi. In children, neuroborreliosis usually presents as peripheral facial nerve palsy and lymphocytic meningitis and only rarely is associated with cranial polyneuritis. PATIENT DESCRIPTION: We present a 15-year-old with tinnitus, hearing loss, and facial nerve palsy in the setting of acute, severe right arm pain and a several week history of malaise and headache. Lumbar puncture was notable for lymphocytic pleocytosis. Serologic testing demonstrated positive Lyme antibody and a positive immunoglobulin M Western blot. Immunofluorescent assay of cerebrospinal fluid was also positive for anti-Lyme immunoglobulin M. Audiologic testing revealed mixed, right-sided hearing loss. Neuroimaging demonstrated cranial polyneuritis and right-sided cochlear inflammation. The patient was treated with parenteral ceftriaxone with resolution of his symptoms at close follow-up. DISCUSSION: Neuroborreliosis with radiculopathy, lymphocytic meningitis, and cranial polyneuritis is a rare presentation of pediatric Lyme disease. Additionally, cochlear inflammation along with cranial nerve VIII inflammation may contribute to hearing loss in patients with neuroborreliosis. C1 [Ewers, Evan C.] Tripler Army Med Ctr, Dept Med, Honolulu, HI 96859 USA. [Dennison, David H.] Walter Reed Natl Mil Med Ctr, Dept Neurol, Bethesda, MD USA. [Stagliano, David R.] Walter Reed Natl Mil Med Ctr, Dept Pediat, Bethesda, MD USA. RP Ewers, EC (reprint author), Tripler Army Med Ctr, Dept Med, Honolulu, HI 96859 USA. EM evan.c.ewers.mil@mail.mil OI Ewers, Evan/0000-0002-1384-9973 NR 10 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0887-8994 EI 1873-5150 J9 PEDIATR NEUROL JI Pediatr. Neurol. PD JAN PY 2015 VL 52 IS 1 BP 107 EP 109 DI 10.1016/j.pediatrneurol.2014.10.009 PG 3 WC Clinical Neurology; Pediatrics SC Neurosciences & Neurology; Pediatrics GA AZ7QA UT WOS:000348411800016 PM 25459362 ER PT J AU Zhu, SH Reuther, J Liu, J Crocker, FH Indest, KJ Eltis, LD Mohn, WW AF Zhu, Song-Hua Reuther, Jens Liu, Jie Crocker, Fiona H. Indest, Karl J. Eltis, Lindsay D. Mohn, William W. TI The essential role of nitrogen limitation in expression of xplA and degradation of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) in Gordonia sp strain KTR9 SO APPLIED MICROBIOLOGY AND BIOTECHNOLOGY LA English DT Article DE RDX degradation; Metabolism; Gene expression/regulation; xplA; GlnR; Bacteria ID REGULATOR GLNR; RHODOCOCCUS; BIODEGRADATION; GENE; BACTERIA; DN22; CYTOCHROME-P-450; ASSIMILATION; METABOLISM; PLASMID AB Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) is a widely used explosive and a major soil and groundwater contaminant. Organisms such as Gordonia sp. KTR9, capable of degrading RDX and using it as an N source, may prove useful for bioremediation of contaminated sites. XplA is a cytochrome P450 monooxygenase responsible for RDX degradation. Expression of xplA in KTR9 was not induced by RDX but was strongly induced (50-fold) during N-limited growth. When glnR, encoding a regulatory protein affecting N assimilation in diverse Actinobacteria, was deleted from KTR9, the bacterium lost the ability to use nitrate, nitrite, and RDX as N sources. Deletion of glnR also abolished the inhibition of xplA expression by nitrite. Our results confirm the essential role of GlnR in regulating assimilation of nitrite, but there was no evidence for a direct role of GlnR in regulating XplA expression. Rather, the general availability of nitrogen repressed XplA expression. We conclude that the inability of the glnR mutant to use RDX as an N source was due to its inability to assimilate nitrite, an intermediate in the assimilation of nitrogen from RDX. Regulation of XplA does not seem adaptive for KTR9, but it is important for RDX bioremediation with KTR9 or similar bacteria. C1 [Zhu, Song-Hua; Reuther, Jens; Liu, Jie; Eltis, Lindsay D.; Mohn, William W.] Univ British Columbia, Dept Microbiol & Immunol, Inst Life Sci, Vancouver, BC V5Z 1M9, Canada. [Crocker, Fiona H.; Indest, Karl J.] US Army Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. RP Mohn, WW (reprint author), Univ British Columbia, Dept Microbiol & Immunol, Inst Life Sci, Vancouver, BC V5Z 1M9, Canada. EM wmohn@mail.ubc.ca RI Eltis, Lindsay/J-8272-2015 OI Eltis, Lindsay/0000-0002-6774-8158 FU Genome BC; Strategic Environmental Research and Development Program [ER-1609]; US Army Corps of Engineers Environmental Quality Program FX This research was funded in part through grants from Genome BC, the Strategic Environmental Research and Development Program (Project ER-1609), and the US Army Corps of Engineers Environmental Quality Program. Views, opinions, and/or findings contained herein are those of the authors and should not be construed as an official Department of the Army position or decision unless so designated by other official documentation. We thank Christine Florizone for guidance in chemical analyses. NR 33 TC 2 Z9 2 U1 2 U2 21 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0175-7598 EI 1432-0614 J9 APPL MICROBIOL BIOT JI Appl. Microbiol. Biotechnol. PD JAN PY 2015 VL 99 IS 1 SI SI BP 459 EP 467 DI 10.1007/s00253-014-6013-z PG 9 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA AY6OK UT WOS:000347685300041 PM 25142696 ER PT J AU O'Reilly, DJ Morrison, JJ Apodoca-Morrison, AN Jansen, JO Midwinter, MJ AF O'Reilly, D. J. Morrison, J. J. Apodoca-Morrison, A. N. Jansen, J. O. Midwinter, M. J. TI Prehospital Blood Transfusion in the En Route Management of Severe Combat Trauma: A Matched Cohort Study SO BRITISH JOURNAL OF SURGERY LA English DT Meeting Abstract CT International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland (ASGBI) CY APR 30-MAY 02, 2014 CL Harrogate, ENGLAND SP Assoc Surg Great Britain & Ireland C1 [O'Reilly, D. J.; Morrison, J. J.; Jansen, J. O.; Midwinter, M. J.] Royal Ctr Def Med, Birmingham, W Midlands, England. [Apodoca-Morrison, A. N.] US Army Inst Surg Res, San Antonio, TX USA. RI Midwinter, Mark/P-6264-2015 OI Midwinter, Mark/0000-0003-1836-7137 NR 0 TC 0 Z9 0 U1 1 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0007-1323 EI 1365-2168 J9 BRIT J SURG JI Br. J. Surg. PD JAN PY 2015 VL 102 SU 1 MA 0187 BP 114 EP 114 PG 1 WC Surgery SC Surgery GA AW8DA UT WOS:000346489700343 ER PT J AU Fries, C Spencer, J Villamaria, C Rickard, R Davis, M AF Fries, C. Spencer, J. Villamaria, C. Rickard, R. Davis, M. TI Hyperbaric Warm Perfusion Maintains Tissue Composites Ex-Vivo Beyond Normal Limits of Cold Ischemia SO BRITISH JOURNAL OF SURGERY LA English DT Meeting Abstract CT International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland (ASGBI) CY APR 30-MAY 02, 2014 CL Harrogate, ENGLAND SP Assoc Surg Great Britain & Ireland C1 [Fries, C.; Spencer, J.; Villamaria, C.; Davis, M.] US Army Inst Surg Res, San Antonio, TX USA. [Rickard, R.] Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0007-1323 EI 1365-2168 J9 BRIT J SURG JI Br. J. Surg. PD JAN PY 2015 VL 102 SU 1 MA 0816 BP 116 EP 117 PG 2 WC Surgery SC Surgery GA AW8DA UT WOS:000346489700353 ER PT J AU Fries, C Spencer, J Villamaria, C Rickard, R Davis, M AF Fries, C. Spencer, J. Villamaria, C. Rickard, R. Davis, M. TI Hydrogen Sulphide Mitigates Ischemia Reperfusion Injury in Vascularised Composite Allotransplantation and Delays the Onset of Acute Rejection SO BRITISH JOURNAL OF SURGERY LA English DT Meeting Abstract CT International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland (ASGBI) CY APR 30-MAY 02, 2014 CL Harrogate, ENGLAND SP Assoc Surg Great Britain & Ireland C1 [Fries, C.; Spencer, J.; Villamaria, C.; Davis, M.] US Army Inst Surg Res, San Antonio, TX USA. [Rickard, R.] Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0007-1323 EI 1365-2168 J9 BRIT J SURG JI Br. J. Surg. PD JAN PY 2015 VL 102 SU 1 MA 0817 BP 117 EP 117 PG 1 WC Surgery SC Surgery GA AW8DA UT WOS:000346489700354 ER PT J AU Ledford, CJW Seehusen, DA Chessman, AW Shokar, NK AF Ledford, Christy J. W. Seehusen, Dean A. Chessman, Alexander W. Shokar, Navkiran K. TI How We Teach US Medical Students to Negotiate Uncertainty in Clinical Care: A CERA Study SO FAMILY MEDICINE LA English DT Article ID DECISION-MAKING; FOLLOW-UP; EDUCATION; MAMMOGRAPHY; PROGNOSIS; ETHICS; FACE AB BACKGROUND AND OBJECTIVES: The patient relies on the physician to help negotiate medical evidence, particularly when experts disagree. For shared decision making to be most effective, the physician must disclose personal uncertainty. This study proposes to describe how uncertainty management is intentionally and systematically taught to medical students. METHODS: A cross-sectional survey was administered to all family medicine clerkship directors (FM CDs) at US allopathic medical schools. Items evaluated the teaching of uncertainty in two domains (instruction and modeling). RESULTS: Eighty-six of 134 (64.18%) FM CDs surveyed completed the survey. Overall, an average of 2.6 hours was devoted to learning about clinical guidelines. The teaching objective addressed least by this sample was discussing uncertainty with the patient. Most curricula do not engage the medical students in how to discuss uncertainty with patients. Hypothesis testing revealed that the clerkship's general attitude toward the importance of teaching students how to deal with competing medical evidence is associated with both instruction and modeling behavior. DISCUSSION: FM CDs demonstrate a positive attitude toward teaching students how to deal with competing evidence. Clerkships do provide students with the opportunity to see faculty engage in uncertainty discussions with patients. Opportunities exist to improve medical student competence in discussing uncertainty in a productive manner. Clerkship directors influence curriculum development and implementation but through their attitude also construct a culture that can be positively aligned with teaching medical students how to negotiate uncertainty in clinical care. C1 [Ledford, Christy J. W.] Uniformed Serv Univ Hlth Sci, Dept Family Med, Bethesda, MD 20814 USA. [Seehusen, Dean A.] Eisenhower Army Med Ctr, Dept Family & Community Med, Ft Gordon, GA USA. [Chessman, Alexander W.] Med Univ S Carolina, Dept Family Med, Charleston, SC USA. [Shokar, Navkiran K.] Texas Tech Univ, Hlth Sci Ctr, Dept Family & Community Med, El Paso, TX USA. RP Ledford, CJW (reprint author), Uniformed Serv Univ Hlth Sci, Dept Family Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM christian.ledford@usuhs.edu NR 35 TC 1 Z9 1 U1 0 U2 1 PU SOC TEACHERS FAMILY MEDICINE PI LEAWOOD PA 11400 TOMAHAWK CREEK PARKWAY, STE 540, LEAWOOD, KS 66207 USA SN 0742-3225 EI 1938-3800 J9 FAM MED JI Fam. Med. PD JAN PY 2015 VL 47 IS 1 BP 31 EP 36 PG 6 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA AZ2ZG UT WOS:000348097100005 PM 25646875 ER PT J AU Richard, R Jones, JA Parshley, P AF Richard, Reg Jones, John A. Parshley, Philip TI Hierarchical Decomposition of Burn Body Diagram Based on Cutaneous Functional Units and Its Utility SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID DONOR-SITE WOUNDS; SURFACE-AREA; HAND; CONTRACTURE; VICTIMS; INJURY; OBESE; NINES; LIFE; RULE AB A burn body diagram (BBD) is a common feature used in the delivery of burn care for estimating the TBSA burn as well as calculating fluid resuscitation and nutritional requirements, wound healing, and rehabilitation intervention. However, little change has occurred for over seven decades in the configuration of the BBD. The purpose of this project was to develop a computerized model using hierarchical decomposition (HD) to more precisely determine the percentage burn within a BBD based on cutaneous functional units (CFUs). HD is a process by which a system is degraded into smaller parts that are more precise in their use. CFUs were previously identified fields of the skin involved in the range of motion. A standard Lund/Browder (LB) BBD template was used as the starting point to apply the CFU segments. LB body divisions were parceled down into smaller body area divisions through a HD process based on the CFU concept. A numerical pattern schema was used to label the various segments in a cephalo/caudal, anterior/posterior, medial/lateral manner. Hand/fingers were divided based on anatomical landmarks and known cutaneokinematic function. The face was considered using aesthetic units. Computer code was written to apply the numeric hierarchical schema to CFUs and applied within the context of the surface area graphic evaluation BBD program. Each segmented CFU was coded to express 100% of itself. The CFU/HD method refined the standard LB diagram from 13 body segments and 33 subdivisions into 182 isolated CFUs. Associated CFUs were reconstituted into 219 various surface area combinations totaling 401 possible surface segments. The CFU/HD schema of the body surface mapping is applicable to measuring and calculating percent wound healing in a more precise manner. It eliminates subjective assessment of the percentage wound healing and the need for additional devices such as planimetry. The development of CFU/HD body mapping schema has rendered a technologically advanced system to depict body burns. The process has led to a more precise estimation of the segmented body areas while preserving the overall TBSA information. Clinical application to date has demonstrated its worthwhile utility. C1 [Richard, Reg; Jones, John A.] US Army, Inst Surg Res, Burn Ctr, Jbsa Ft Sam Houston, TX 78234 USA. [Parshley, Philip] SAGE Diagram LLC, Portland, OR USA. RP Richard, R (reprint author), Inst Surg Res, 3698 Chambers Pass,STE B, Jbsa Ft Sam Houston, TX 78234 USA. FU Department of Defense [W81XWH-08-1-0683] FX This study was funded by the Department of Defense W81XWH-08-1-0683. NR 40 TC 2 Z9 2 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1559-047X EI 1559-0488 J9 J BURN CARE RES JI J. Burn Care Res. PD JAN-FEB PY 2015 VL 36 IS 1 BP 33 EP 43 DI 10.1097/BCR.0000000000000150 PG 11 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA AY3AG UT WOS:000347456400008 PM 25162946 ER PT J AU Reiter, MJ Bui-Mansfield, LT O'Brien, SD Tubb, CC AF Reiter, Michael J. Bui-Mansfield, Liem T. O'Brien, Seth D. Tubb, Creighton C. TI Subtrochanteric Femur Fractures: Review of the Complete Pathologic Spectrum With Emphasis on Distinguishing Imaging Features SO JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY LA English DT Review DE subtrochanteric femur fracture; bisphosphonate-associated fracture; pathologic fracture; Paget disease; subsidence ID LONGITUDINAL STRESS-FRACTURES; ATYPICAL FEMORAL FRACTURES; BISPHOSPHONATE THERAPY; HIP-ARTHROPLASTY; PAGETS-DISEASE; BONE; COMPLICATIONS; NECK; TOMOGRAPHY; APPEARANCE AB Subtrochanteric femur fractures result from a variety of mechanisms of injury and underlying pathologies. Radiologists can play a pivotal role by differentiating the etiology of a subtrochanteric femur fracture, which assists the orthopedic surgeon in choosing the correct method of treatment. To provide this valuable service, onemust be familiar with the characteristic radiologic features of the numerous causative etiologies, ranging from Paget disease to underlying bone lesions to iatrogenic fractures. C1 [Reiter, Michael J.; Bui-Mansfield, Liem T.; O'Brien, Seth D.] Brooke Army Med Ctr, Dept Radiol, San Antonio, TX 78234 USA. [Reiter, Michael J.; Bui-Mansfield, Liem T.; O'Brien, Seth D.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Tubb, Creighton C.] Brooke Army Med Ctr, Dept Orthoped Surg, San Antonio, TX 78234 USA. RP Reiter, MJ (reprint author), Brooke Army Med Ctr, Dept Radiol, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA. EM mikereiter13@yahoo.com NR 55 TC 1 Z9 1 U1 3 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0363-8715 EI 1532-3145 J9 J COMPUT ASSIST TOMO JI J. Comput. Assist. Tomogr. PD JAN-FEB PY 2015 VL 39 IS 1 BP 47 EP 56 PG 10 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA AZ4IG UT WOS:000348184200009 PM 25354094 ER PT J AU Johnson, BW Madson, AQ Bong-Thakur, S Tucker, D Hale, RG Chan, RK AF Johnson, Benjamin W. Madson, Andrew Q. Bong-Thakur, Sarah Tucker, David Hale, Robert G. Chan, Rodney K. TI Combat-Related Facial Burns: Analysis of Strategic Pitfalls SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Article ID OPERATION IRAQI FREEDOM; US MILITARY OPERATIONS; ENDURING FREEDOM; CRANIOMAXILLOFACIAL INJURIES; EARLY EXCISION; NECK; FACE; WOUNDS; WAR AB Purpose: Burns constitute approximately 10% of all combat-related injuries to the head and neck region. We postulated that the combat environment presents unique challenges not commonly encountered among civilian injuries. The purpose of the present study was to determine the features commonly seen among combat facial burns that will result in therapeutic challenges and might contribute to undesired outcomes. Materials and Methods: The present study was a retrospective study performed using a query of the Burn Registry at the US Army Institute of Surgical Research Burn Center for all active duty facial burn admissions from October 2001 to February 2011. The demographic data, total body surface area of the burn, facial region body surface area involvement, and dates of injury, first operation, and first facial operation were tabulated and compared. A subset analysis of severe facial burns, defined by a greater than 7% facial region body surface area, was performed with a thorough medical record review to determine the presence of associated injuries. Results: Of all the military burn injuries, 67.1% (n = 558) involved the face. Of these, 81.3% (n = 454) were combat related. The combat facial burns had a mean total body surface area of 21.4% and a mean facial region body surface area of 3.2%. The interval from the date of the injury to the first operative encounter was 6.6 +/- 0.8 days and was 19.8 +/- 2.0 days to the first facial operation. A subset analysis of the severe facial burns revealed that the first facial operation and the definitive coverage operation was performed at 13.45 +/- 2.6 days and 31.9 +/- 4.1 days after the injury, respectively. The mortality rate for this subset of patients was 32% (n = 10), with a high rate of associated inhalational injuries (61%, n = 19), limb amputations (29%, n = 9), and facial allograft usage (48%, n = 15) and a mean facial autograft thickness of 10.5/1,000th in. Conclusions: Combat-related facial burns present multiple challenges, which can contribute to suboptimal long-term outcomes. These challenges include prolonged transport to the burn center, delayed initial intervention and definitive coverage, and a lack of available high-quality color-matched donor skin. These gaps all highlight the need for novel anti-inflammatory and skin replacement strategies to more adequately address these unique combat-related obstacles. (C) 2015 American Association of Oral and Maxillofacial Surgeons C1 [Johnson, Benjamin W.] San Antonio Mil Med Ctr, Dept Oral & Maxillofacial Surg, Ft Sam Houston, TX 78234 USA. [Madson, Andrew Q.] US Army, Inst Surg Res, Burn Ctr, Ft Sam Houston, TX 78234 USA. [Madson, Andrew Q.] US Army, Inst Surg Res, Clin Div, Ft Sam Houston, TX 78234 USA. [Bong-Thakur, Sarah; Tucker, David; Hale, Robert G.; Chan, Rodney K.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Chan, RK (reprint author), San Antonio Mil Med Ctr, Dept Oral & Maxillofacial Surg, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM rodney.k.chan.ctr@mail.mil NR 25 TC 2 Z9 2 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0278-2391 EI 1531-5053 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD JAN PY 2015 VL 73 IS 1 BP 106 EP 111 DI 10.1016/j.joms.2014.08.022 PG 6 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA AY6ZZ UT WOS:000347712300018 PM 25511961 ER PT J AU Islam, MM Ostadhossein, A Borodin, O Yeates, AT Tipton, WW Hennig, RG Kumar, N van Duin, ACT AF Islam, Md Mahbubul Ostadhossein, Alireza Borodin, Oleg Yeates, A. Todd Tipton, William W. Hennig, Richard G. Kumar, Nitin van Duin, Adri C. T. TI ReaxFF molecular dynamics simulations on lithiated sulfur cathode materials SO PHYSICAL CHEMISTRY CHEMICAL PHYSICS LA English DT Article ID REACTIVE FORCE-FIELD; RECHARGEABLE LITHIUM BATTERIES; HIGH SPECIFIC ENERGY; LI-S BATTERIES; SOLID-ELECTROLYTE; ION BATTERIES; AB-INITIO; ENCAPSULATED SULFUR; SILICON ELECTRODES; LIQUID ELECTROLYTE AB Sulfur is a very promising cathode material for rechargeable energy storage devices. However, sulfur cathodes undergo a noticeable volume variation upon cycling, which induces mechanical stress. In spite of intensive investigation of the electrochemical behavior of the lithiated sulfur compounds, their mechanical properties are not very well understood. In order to fill this gap, we developed a ReaxFF interatomic potential to describe Li-S interactions and performed molecular dynamics (MD) simulations to study the structural, mechanical, and kinetic behavior of the amorphous lithiated sulfur (a-LixS) compounds. We examined the effect of lithiation on material properties such as ultimate strength, yield strength, and Young's modulus. Our results suggest that with increasing lithium content, the strength of lithiated sulfur compounds improves, although this increment is not linear with lithiation. The diffusion coefficients of both lithium and sulfur were computed for the a-LixS system at various stages of Li-loading. A grand canonical Monte Carlo (GCMC) scheme was used to calculate the open circuit voltage profile during cell discharge. The Li-S binary phase diagram was constructed using genetic algorithm based tools. Overall, these simulation results provide insight into the behavior of sulfur based cathode materials that are needed for developing lithium-sulfur batteries. C1 [Islam, Md Mahbubul; van Duin, Adri C. T.] Penn State Univ, Dept Mech & Nucl Engn, University Pk, PA 16802 USA. [Ostadhossein, Alireza] Penn State Univ, Dept Engn Sci & Mech, University Pk, PA 16802 USA. [Borodin, Oleg] US Army, Res Lab, Electrochem Branch, Adelphi, MD 20783 USA. [Yeates, A. Todd] US Air Force, Res Lab, Mat & Mfg Directorate, AFRL RXBN, Wright Patterson AFB, OH 45433 USA. [Tipton, William W.; Hennig, Richard G.] Cornell Univ, Dept Mat Sci & Engn, Ithaca, NY 14853 USA. [Kumar, Nitin] Sandia Natl Labs, Albuquerque, NM 87185 USA. RP van Duin, ACT (reprint author), Penn State Univ, Dept Mech & Nucl Engn, University Pk, PA 16802 USA. EM acv13@psu.edu RI Islam, Md Mahbubul/O-9375-2015; Borodin, Oleg/B-6855-2012; Hennig, Richard/A-2978-2008 OI Islam, Md Mahbubul/0000-0003-4584-2204; Borodin, Oleg/0000-0002-9428-5291; Hennig, Richard/0000-0003-4933-7686 FU US Army Research Laboratory through the Collaborative Research Alliance (CRA) for Multi Scale Multidisciplinary Modeling of Electronic Materials (MSME); DoD High Performance Computing (HPC) Productivity Enhancement, Technology Transfer, and Training (PETTT) Program [PP-CCM-KY03-005-P3] FX This work was supported by the grant from the US Army Research Laboratory through the Collaborative Research Alliance (CRA) for Multi Scale Multidisciplinary Modeling of Electronic Materials (MSME) and DoD High Performance Computing (HPC) Productivity Enhancement, Technology Transfer, and Training (PETTT) Program contract number PP-CCM-KY03-005-P3. NR 84 TC 25 Z9 25 U1 8 U2 106 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1463-9076 EI 1463-9084 J9 PHYS CHEM CHEM PHYS JI Phys. Chem. Chem. Phys. PY 2015 VL 17 IS 5 BP 3383 EP 3393 DI 10.1039/c4cp04532g PG 11 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA AZ4OW UT WOS:000348203200047 PM 25529209 ER PT J AU Morasch, KC Aaron, CL Moon, JE Gordon, RK AF Morasch, Katherine C. Aaron, Christopher L. Moon, James E. Gordon, Richard K. TI Physiological and neurobehavioral effects of cholinesterase inhibition in healthy adults SO PHYSIOLOGY & BEHAVIOR LA English DT Article DE Organophosphate prophylaxis; Acetylcholinesterase inhibition; Neurobehavioral performance; Huperzine A; Galantamine; Donepezil ID SLEEP-DEPRIVATION; HUPERZINE-A; ALZHEIMERS-DISEASE; EPISODIC MEMORY; YOUNG-ADULTS; PERFORMANCE; DONEPEZIL; ACETYLCHOLINESTERASE; PYRIDOSTIGMINE; VOLUNTEERS AB Introduction: Based on common pharmacodynamic mechanisms, recent efforts to develop second generation alternatives for organophosphate (OP) prophylaxis have expanded to include cholinesterase (ChE) inhibiting compounds traditionally approved for use in the treatment of Alzheimer's disease (AD). The primary purpose of this study was to determine the extent to which low-dose huperzine A, galantamine, or donepezil selectively inhibited acetylcholinesterase (AChE) versus butyrylcholinesterase (BChE) activity in healthy adults and whether such inhibition impacted neurobehavioral performance. Methods: In addition to hourly red blood cell cholinesterase sampling, neurobehavioral function was assessed before and after a single oral dose of huperzine A (100 or 200 Kg), galantamine (4 or 8 mg), donepezil (2.5 or 5 mg), or placebo (n = 12 subjects per drug/dose). Results: Compared to placebo, both dosages of huperzine A and galantamine inhibited circulating AChE but not BChE. With the exception of huperzine A (200 jig), which maintained declarative recall performance across sessions, compounds did not improve neurobehavioral performance. Some aspects of neurobehavioral performance correlated with AChE activity, although associations may have reflected time of day effects. Discussion: Although huperzine A and galantamine significantly inhibited AChE (and likely increased central acetylcholine levels), neither compound improved neurobehavioral performance. The latter was likely due to ceiling effects in this young, healthy test population. Under conditions of reduced cholinergic activity (e.g., Alzheimer's disease), AChE inhibition (and corresponding maintenance of cholinergic tone) could potentially maintain/augment some aspects of neurobehavioral function. Published by Elsevier Inc. C1 [Morasch, Katherine C.; Moon, James E.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Aaron, Christopher L.] Ft Belvoir Community Hosp, Ft Belvoir, VA 22060 USA. RP Morasch, KC (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM kmorasch@gmail.com RI Moon, James/B-6810-2011 OI Moon, James/0000-0002-9274-4554 FU DTRA project [CBM.NEURO.01.10 WR020] FX The authors would like to acknowledge Ms. Ruthie Ratcliffe and Ms. Rachel Newman for data collection, Ms. Linda Harvey for conducting the whole blood cholinesterase assays, and Nancy Wesensten, Ph.D. for her substantial contributions to this work. We thank Franklin Volvovitz, Ph.D., of Biomedisyn Corporation, for providing huperzine A. This project was supported by DTRA project # CBM.NEURO.01.10 WR020. NR 32 TC 1 Z9 1 U1 2 U2 21 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0031-9384 J9 PHYSIOL BEHAV JI Physiol. Behav. PD JAN PY 2015 VL 138 BP 165 EP 172 DI 10.1016/j.physbeh.2014.09.010 PG 8 WC Psychology, Biological; Behavioral Sciences SC Psychology; Behavioral Sciences GA CA4OA UT WOS:000348882900023 PM 25455867 ER PT J AU Loan, HK Cuong, NV Takhampunya, R Kiet, BT Campbell, J Them, LN Bryant, JE Tippayachai, B Hoang, NV Morand, S Hien, VB Carrique-Mas, JJ AF Hoang Kim Loan Nguyen Van Cuong Takhampunya, Ratree Kiet, Bach Tuan Campbell, James Lac Ngoc Them Bryant, Juliet E. Tippayachai, Bousaraporn Nguyen Van Hoang Morand, Serge Vo Be Hien Carrique-Mas, Juan J. TI How Important Are Rats As Vectors of Leptospirosis in the Mekong Delta of Vietnam? SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Mekong Delta, Vietnam; Leptospirosis; Rats ID RISK-FACTORS; PATHOGENIC LEPTOSPIRA; RODENTS; INTERROGANS; SEROPOSITIVITY; ANTIBODIES; CARRIAGE; BRAZIL; ISLAND; SPP. AB Leptospirosis is a zoonosis known to be endemic in the Mekong Delta of Vietnam, even though clinical reports are uncommon. We investigated leptospira infection in rats purchased in food markets during the rainy season (October) (n=150), as well as those trapped during the dry season (February-March) (n=125) in the region using RT-PCR for the lipL32 gene, confirmed by 16S rRNA, as well as by the microscopic agglutination test (MAT). Results were compared with the serovar distribution of human cases referred from Ho Chi Minh City hospitals (2004-2012) confirmed by MAT (n=45). The MAT seroprevalence among rats was 18.3%. The highest MAT seroprevalence corresponded, in decreasing order, to: Rattus norvegicus (33.0%), Bandicota indica (26.5%), Rattus tanezumi (24.6%), Rattus exulans (14.3%), and Rattus argentiventer (7.1%). The most prevalent serovars were, in descending order: Javanica (4.6% rats), Lousiana (4.2%), Copenageni (4.2%), Cynopterie (3.7%), Pomona (2.9%), and Icterohaemorrhagiae (2.5%). A total of 16 rats (5.8%) tested positive by RT-PCR. Overall, larger rats tended to have a higher prevalence of detection. There was considerable agreement between MAT and PCR (kappa=0.28 [0.07-0.49]), although significantly more rats were positive by MAT (McNemar 29.9 (p<0.001). MAT prevalence was higher among rats during the rainy season compared with rats in the dry season. There are no current available data on leptospira serovars in humans in the Mekong Delta, although existing studies suggest limited overlapping between human and rat serovars. Further studies should take into account a wider range of potential reservoirs (i.e., dogs, pigs) as well as perform geographically linked co-sampling of humans and animals to establish the main sources of leptospirosis in the region. C1 [Hoang Kim Loan; Lac Ngoc Them] Inst Pasteur, Ho Chi Minh City, Vietnam. [Nguyen Van Cuong; Campbell, James; Bryant, Juliet E.; Carrique-Mas, Juan J.] Univ Oxford, Clin Res Unit, Ho Chi Minh City, Vietnam. [Takhampunya, Ratree; Campbell, James; Bryant, Juliet E.; Carrique-Mas, Juan J.] Univ Oxford, Nuffield Dept Med, Oxford, England. [Kiet, Bach Tuan; Nguyen Van Hoang; Vo Be Hien] Subdept Anim Hlth, Dong Thap, Vietnam. [Tippayachai, Bousaraporn] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Morand, Serge] Univ Montpellier 2, ISEM, CNRS, IRD, F-34095 Montpellier 5, France. RP Carrique-Mas, JJ (reprint author), Univ Oxford, Clin Res Unit, Wellcome Trust Major Overseas Programme, 764 Vo Van Kiet,Ward 1,Dist 5, Ho Chi Minh City, Vietnam. EM jcarrique-mas@oucru.org FU Li-Ka-Shing Foundation; Wellcome Trust [WT/093724]; Agence Nationale de la Recherche (France) [ANR-11-CEPL-002-01] FX We are grateful to staff of the sub-Department of Animal Health in Dong Thap province and to Yannick Chaval of the Centre Nationale de la Recherche Scientifique for technical support. This work was partly supported by the Li-Ka-Shing Foundation as well as the Wellcome Trust-funded project Vietnam Initiative for Zoonotic Infections (VIZIONS) (WT/093724). Dr. Serge Morand was funded by the Agence Nationale de la Recherche (France) through ANR-11-CEPL-002-01, project BioDivHealth SEA. NR 36 TC 1 Z9 1 U1 2 U2 6 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 EI 1557-7759 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD JAN 1 PY 2015 VL 15 IS 1 SI SI BP 56 EP 64 DI 10.1089/vbz.2014.1613 PG 9 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA AZ9YM UT WOS:000348570600008 PM 25629781 ER PT J AU Conger, NG Paolino, KM Osborn, EC Rusnak, JM Gunther, S Pool, J Rollin, PE Allan, PF Schmidt-Chanasit, J Rieger, T Kortepeter, MG AF Conger, Nicholas G. Paolino, Kristopher M. Osborn, Erik C. Rusnak, Janice M. Guenther, Stephan Pool, Jane Rollin, Pierre E. Allan, Patrick F. Schmidt-Chanasit, Jonas Rieger, Toni Kortepeter, Mark G. TI Health Care Response to CCHF in US Soldier and Nosocomial Transmission to Health Care Providers, Germany, 2009 SO EMERGING INFECTIOUS DISEASES LA English DT Article ID CONGO HEMORRHAGIC-FEVER; SERUM-LEVELS; VIRAL LOAD; VIRUS; ACTIVATION; TURKEY; CELLS; PATHOGENESIS; INTERFERON; PROGNOSIS AB In 2009, a lethal case of Crimean Congo hemorrhagic fever (CCHF), acquired by a US soldier in Afghanistan, was treated at a medical center in Germany and resulted in nosocomial transmission to 2 health care providers (HCPs). After his arrival at the medical center (day 6 of illness) by aeromedical evacuation, the patient required repetitive bronchoscopies to control severe pulmonary hemorrhage and renal and hepatic dialysis for hepatorenal failure. After showing clinical improvement, the patient died suddenly on day 11 of illness from cerebellar tonsil herniation caused by cerebral/cerebellar edema. The 2 infected HCPs were among 16 HCPs who received ribavirin postexposure prophylaxis. The infected HCPs had mild or no CCHF symptoms. Transmission may have occurred during bag-valve-mask ventilation, breaches in personal protective equipment during resuscitations, or bronchoscopies generating infectious aerosols. This case highlights the critical care and infection control challenges presented by severe CCHF cases, including the need for experience with ribavirin treatment and postexposure prophylaxis. C1 [Conger, Nicholas G.; Osborn, Erik C.; Pool, Jane; Allan, Patrick F.] Landstuhl Reg Med Ctr, Landstuhl, Germany. [Paolino, Kristopher M.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Rusnak, Janice M.] Force Hlth Protect, Ft Detrick, MD USA. [Guenther, Stephan; Schmidt-Chanasit, Jonas; Rieger, Toni] Bernhard Nocht Inst Trop Med, D-20359 Hamburg, Germany. [Rollin, Pierre E.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Kortepeter, Mark G.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Conger, NG (reprint author), Wright Patterson Med Ctr, 4881 Sugar Maple Dr, Wright Patterson AFB, OH 45433 USA. EM nicholas.conger@us.af.mil NR 40 TC 15 Z9 16 U1 0 U2 3 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JAN PY 2015 VL 21 IS 1 BP 23 EP 31 DI 10.3201/eid2101.141413 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AY3SW UT WOS:000347503700004 PM 25529825 ER PT J AU Kessler, RC Warner, CH Ivany, C Petukhova, MV Rose, S Bromet, EJ Brown, M Cai, TX Colpe, LJ Cox, KL Fullerton, CS Gilman, SE Gruber, MJ Heeringa, SG Lewandowski-Romps, L Li, JL Millikan-Bell, A Naifeh, JA Nock, MK Rosellini, AJ Sampson, NA Schoenbaum, M Stein, MB Wessely, S Zaslavsky, AM Ursano, RJ AF Kessler, Ronald C. Warner, Christopher H. Ivany, Christopher Petukhova, Maria V. Rose, Sherri Bromet, Evelyn J. Brown, Millard, III Cai, Tianxi Colpe, Lisa J. Cox, Kenneth L. Fullerton, Carol S. Gilman, Stephen E. Gruber, Michael J. Heeringa, Steven G. Lewandowski-Romps, Lisa Li, Junlong Millikan-Bell, Amym. Naifeh, James A. Nock, Matthew K. Rosellini, Anthony J. Sampson, Nancy A. Schoenbaum, Michael Stein, Murray B. Wessely, Simon Zaslavsky, Alan M. Ursano, Robert J. CA Army STARRS Collaborators TI Predicting Suicides After Psychiatric Hospitalization in US Army Soldiers The Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS) SO JAMA PSYCHIATRY LA English DT Article ID DECISION-SUPPORT-SYSTEMS; INPATIENT CARE; PREVENTION; DISCHARGE; METAANALYSIS; REGRESSION; DEPRESSION; ATTEMPTORS; BEHAVIOR; PERIODS AB IMPORTANCE The US Army experienced a sharp increase in soldier suicides beginning in 2004. Administrative data reveal that among those at highest risk are soldiers in the 12 months after inpatient treatment of a psychiatric disorder. OBJECTIVE To develop an actuarial risk algorithm predicting suicide in the 12 months after US Army soldier inpatient treatment of a psychiatric disorder to target expanded posthospitalization care. DESIGN, SETTING, AND PARTICIPANTS There were 53 769 hospitalizations of active duty soldiers from January 1, 2004, through December 31, 2009, with International Classification of Diseases, Ninth Revision, Clinical Modification psychiatric admission diagnoses. Administrative data available before hospital discharge abstracted from a wide range of data systems (sociodemographic, US Army career, criminal justice, and medical or pharmacy) were used to predict suicides in the subsequent 12 months using machine learning methods (regression trees and penalized regressions) designed to evaluate cross-validated linear, nonlinear, and interactive predictive associations. MAIN OUTCOMES AND MEASURES Suicides of soldiers hospitalized with psychiatric disorders in the 12 months after hospital discharge. RESULTS Sixty-eight soldiers died by suicide within 12 months of hospital discharge (12.0% of all US Army suicides), equivalent to 263.9 suicides per 100 000 person-years compared with 18.5 suicides per 100 000 person-years in the total US Army. The strongest predictors included sociodemographics (male sex [odds ratio (OR), 7.9; 95% CI, 1.9-32.6] and late age of enlistment [OR, 1.9; 95% CI, 1.0-3.5]), criminal offenses (verbal violence [OR, 2.2; 95% CI, 1.2-4.0] and weapons possession [OR, 5.6; 95% CI, 1.7-18.3]), prior suicidality [OR, 2.9; 95% CI, 1.7-4.9], aspects of prior psychiatric inpatient and outpatient treatment (eg, number of antidepressant prescriptions filled in the past 12 months [OR, 1.3; 95% CI, 1.1-1.7]), and disorders diagnosed during the focal hospitalizations (eg, nonaffective psychosis [OR, 2.9; 95% CI, 1.2-7.0]). A total of 52.9% of posthospitalization suicides occurred after the 5% of hospitalizations with highest predicted suicide risk (3824.1 suicides per 100 000 person-years). These highest-risk hospitalizations also accounted for significantly elevated proportions of several other adverse posthospitalization outcomes (unintentional injury deaths, suicide attempts, and subsequent hospitalizations). CONCLUSIONS AND RELEVANCE The high concentration of risk of suicide and other adverse outcomes might justify targeting expanded posthospitalization interventions to soldiers classified as having highest posthospitalization suicide risk, although final determination requires careful consideration of intervention costs, comparative effectiveness, and possible adverse effects. C1 [Kessler, Ronald C.; Petukhova, Maria V.; Rose, Sherri; Gruber, Michael J.; Rosellini, Anthony J.; Sampson, Nancy A.; Zaslavsky, Alan M.] Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 USA. [Warner, Christopher H.] Blanchfield Army Community Hosp, Dept Behav Med, Ft Campbell, KY USA. [Ivany, Christopher; Brown, Millard, III] US Army Off Surg Gen, Falls Church, VA USA. [Bromet, Evelyn J.] SUNY Stony Brook, Sch Med, Dept Psychiat, Stony Brook, NY 11794 USA. [Cai, Tianxi; Li, Junlong] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. [Colpe, Lisa J.; Schoenbaum, Michael] NIMH, Bethesda, MD 20892 USA. [Cox, Kenneth L.; Millikan-Bell, Amym.] US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA. [Fullerton, Carol S.; Naifeh, James A.; Ursano, Robert J.] Uniformed Serv Univ Hlth Sci, Ctr Study Traumat Stress, Bethesda, MD 20814 USA. [Gilman, Stephen E.] Harvard Univ, Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA 02115 USA. [Gilman, Stephen E.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Heeringa, Steven G.; Lewandowski-Romps, Lisa] Univ Michigan, Inst Social Res, Ann Arbor, MI USA. [Nock, Matthew K.] Harvard Univ, Dept Psychol, Cambridge, MA 02138 USA. [Stein, Murray B.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA. [Stein, Murray B.] Univ Calif San Diego, Deapartment Family & Prevent Med, La Jolla, CA 92093 USA. [Stein, Murray B.] Vet Affairs San Diego Healthcare Syst, San Diego, CA USA. [Wessely, Simon] Kings Coll London, Kings Ctr Mil Hlth Res, London WC2R 2LS, England. RP Kessler, RC (reprint author), Harvard Univ, Sch Med, Dept Hlth Care Policy, 180 Longwood Ave,Ste 215, Boston, MA 02115 USA. EM kessler@hcp.med.harvard.edu RI Gilman, Stephen/E-7632-2010; Wessely, Simon/A-8713-2008 OI Gilman, Stephen/0000-0002-8331-6419; FU US Department of the Army; National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services; [U01MH087981] FX The Army STARRS was sponsored by the US Department of the Army and funded under cooperative agreement U01MH087981 with the National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services. NR 48 TC 28 Z9 28 U1 6 U2 23 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-622X EI 2168-6238 J9 JAMA PSYCHIAT JI JAMA Psychiatry PD JAN PY 2015 VL 72 IS 1 BP 49 EP 57 DI 10.1001/jamapsychiatry.2014.1754 PG 9 WC Psychiatry SC Psychiatry GA AY5KJ UT WOS:000347610700007 PM 25390793 ER PT J AU Bailie, JM Cole, WR Ivins, B Boyd, C Lewis, S Neff, J Schwab, K AF Bailie, Jason M. Cole, Wesley R. Ivins, Brian Boyd, Cynthia Lewis, Steven Neff, John Schwab, Karen TI The Experience, Expression, and Control of Anger Following Traumatic Brain Injury in a Military Sample SO JOURNAL OF HEAD TRAUMA REHABILITATION LA English DT Article DE anger; explosive blast injury; military injury; traumatic brain injury ID POSTTRAUMATIC-STRESS-DISORDER; AFGHANISTAN WAR VETERANS; HEAD-INJURY; MANAGEMENT THERAPY; AGGRESSION; MILD; IRAQ; IRRITABILITY; HOSTILITY; SYMPTOMS AB Objective: To investigate the impact of traumatic brain injury (TBI) on the experience and expression of anger in a military sample. Participants: A total of 661 military personnel with a history of TBI and 1204 military personnel with no history of TBI. Design: Cross-sectional, between-group design, using multivariate analysis of variance. Main Measure: State-Trait Anger Expression Inventory-2 (STAXI-2). Results: Participants with a history of TBI had higher scores on the STAXI-2 than controls and were 2 to 3 times more likely than the participants in the control group to have at least 1 clinically significant elevation on the STAXI-2. Results suggested that greater time since injury (ie, months between TBI and assessment) was associated with lower scores on the STAXI-2 State Anger scale. Conclusion: Although the results do not take into account confounding psychiatric conditions and cannot address causality, they suggest that a history of TBI increases the risk of problems with the experience, expression, and control of anger. This bolsters the need for proper assessment of anger when evaluating TBI in a military cohort. C1 [Bailie, Jason M.; Boyd, Cynthia; Neff, John] Naval Med Ctr San Diego, Def & Vet Brain Injury Ctr, San Diego, CA 92134 USA. [Bailie, Jason M.; Cole, Wesley R.; Boyd, Cynthia] Adv Mil Med Inc, Henry M Jackson Fdn, Bethesda, MD USA. [Ivins, Brian] Adv Mil Med Inc, Henry M Jackson Fdn, Washington, DC USA. [Ivins, Brian] Def & Vet Brain Injury Ctr, Washington, DC USA. [Cole, Wesley R.; Lewis, Steven] Def & Vet Brain Injury Ctr, Ft Bragg, NC USA. [Lewis, Steven] Womack Army Med Ctr, Dept Traumat Brain Injury, Ft Bragg, NC USA. [Neff, John] US Navy, Rehabil Med, San Diego, CA 92152 USA. [Schwab, Karen] Def & Vet Brain Injury Ctr, Epidemiol & Res Support Serv, Washington, DC USA. RP Bailie, JM (reprint author), Naval Med Ctr San Diego, Def & Vet Brain Injury Ctr, 34730 Bob Wilson Dr,Ste 201, San Diego, CA 92134 USA. EM jason.bailie.ctr@med.navy.mil FU [W91YTZ-12-C-0132] FX Research on this article was done under contract # W91YTZ-12-C-0132. NR 40 TC 1 Z9 1 U1 6 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0885-9701 EI 1550-509X J9 J HEAD TRAUMA REHAB JI J. Head Trauma Rehabil. PD JAN-FEB PY 2015 VL 30 IS 1 BP 12 EP 20 DI 10.1097/HTR.0000000000000024 PG 9 WC Clinical Neurology; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA AY8BW UT WOS:000347780400010 PM 24590149 ER PT J AU Pugh, MJV Orman, JA Jaramillo, CA Salinsky, MC Eapen, BC Towne, AR Amuan, ME Roman, G McNamee, SD Kent, TA McMillan, KK Hamid, H Grafman, JH AF Pugh, Mary Jo V. Orman, Jean A. Jaramillo, Carlos A. Salinsky, Martin C. Eapen, Blessen C. Towne, Alan R. Amuan, Megan E. Roman, Gustavo McNamee, Shane D. Kent, Thomas A. McMillan, Katharine K. Hamid, Hamada Grafman, Jordan H. TI The Prevalence of Epilepsy and Association With Traumatic Brain Injury in Veterans of the Afghanistan and Iraq Wars SO JOURNAL OF HEAD TRAUMA REHABILITATION LA English DT Article DE epidemiology; epilepsy; traumatic brain injury; Veterans ID ONSET UNPROVOKED SEIZURES; PENETRATING HEAD-INJURY; POSTTRAUMATIC EPILEPSY; BIDIRECTIONAL RELATION; ADMINISTRATIVE DATA; ANTIEPILEPTIC DRUG; CHRONIC PAIN; DISORDERS; COMORBIDITY; HYPERTENSION AB Objective: To examine the association of epilepsy with traumatic brain injury (TBI) in Afghanistan and Iraq (Operation Enduring Freedom [OEF]/Operation Iraqi Freedom [OIF]) Veterans. Design: Cross-sectional observational study. Participants: A total 256 284 OEF/OIF Veterans who received inpatient and outpatient care in the Veterans Health Administration in fiscal years 2009-2010. Main Outcome Measures: We used algorithms developed for use with International Classification of Diseases, Ninth Revision, Clinical Modification, codes to identify epilepsy, TBI (penetrating TBI [pTBI]/other TBI), and other risk factors for epilepsy (eg, stroke). TBI and other risk factors were identified prior to the index date (first date of seizure or October 1, 2009) for primary analyses. Results: Epilepsy prevalence was 10.6 per 1000 (N = 2719) in fiscal year 2010; age-adjusted prevalence was 6.1. Of 37 718 individuals with a diagnosis of TBI, 29 297 Veterans had a diagnosis of TBI prior to the index date. Statistically significant associations were found between epilepsy and prior TBI diagnosis (pTBI: adjusted odds ratio = 18.77 [95% confidence interval, 9.21-38.23]; other TBI: adjusted odds ratio = 1.64 [1.43-1.89]). Conclusions: Among OEF/OIF Veterans, epilepsy was associated with previous TBI diagnosis, with pTBI having the strongest association. Because war-related epilepsy in Vietnam War Veterans with TBI continued 35 years postwar, a detailed, prospective study is needed to understand the relationship between epilepsy and TBI severity in OEF/OIF Veterans. C1 [Pugh, Mary Jo V.; McMillan, Katharine K.] South Texas Vet Hlth Care Syst VERDICT, San Antonio, TX USA. [Pugh, Mary Jo V.; Orman, Jean A.; McMillan, Katharine K.] Univ Texas Hlth Sci Ctr San Antonio, Dept Epidemiol & Biostat, San Antonio, TX 78229 USA. [Pugh, Mary Jo V.] Texas A&M Univ, Dept Med, Sch Med, College Stn, TX 77843 USA. [Orman, Jean A.] US Army Inst Surg Res, Houston, TX USA. [Orman, Jean A.] Univ Texas San Antonio, Sch Publ Hlth, San Antonio, TX USA. [Jaramillo, Carlos A.; Eapen, Blessen C.] UT Hlth Sci Ctr San Antonio, Dept Rehabil Med, Polytrauma Rehabil Ctr South Texas Vet Hlth Care, San Antonio, TX USA. [Salinsky, Martin C.] Portland VA Med Ctr, Portland, OR USA. [Salinsky, Martin C.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. [Towne, Alan R.] Virginia Commonwealth Univ, Richmond, VA 23284 USA. [Towne, Alan R.] McGuire Vet Adm Hosp, Epilepsy Ctr Excellence, Richmond, VA USA. [Amuan, Megan E.] Edith Nourse Rogers Mem Hosp, CHQOER, Bedford, MA USA. [Roman, Gustavo] Methodist Neurol Inst, Nantz Natl Alzheimer Ctr, Houston, TX USA. [McNamee, Shane D.] Hunter Holmes McGuire Vet Adm Hosp, Phys Med & Rehabil Serv, Richmond, VA USA. [Kent, Thomas A.] Michael E DeBakey VA Med Ctr, Houston, TX USA. [Kent, Thomas A.] Baylor Coll Med, Houston, TX 77030 USA. [Hamid, Hamada] West Haven VA Med Ctr, West Haven, CT USA. [Grafman, Jordan H.] Rehabil Inst Chicago, Chicago, IL 60611 USA. RP Pugh, MJV (reprint author), South Texas Vet Hlth Care Syst ALMD, 7400 Merton Minter Blvd 11C6, San Antonio, TX 78229 USA. EM pughm@uthscsa.edu OI Kent, Thomas/0000-0002-9877-7584; Grafman, Jordan H./0000-0001-8645-4457 FU VA Health Services Research and Development [DHI 09-237] FX The study was funded by VA Health Services Research and Development (DHI 09-237). Administrative, technical, or material support was provided by Kathleen Franklin, South Texas Veterans Healthcare System. Data analysis was conducted by Ms Amuan. NR 51 TC 8 Z9 8 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0885-9701 EI 1550-509X J9 J HEAD TRAUMA REHAB JI J. Head Trauma Rehabil. PD JAN-FEB PY 2015 VL 30 IS 1 BP 29 EP 37 DI 10.1097/HTR.0000000000000045 PG 9 WC Clinical Neurology; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA AY8BW UT WOS:000347780400012 PM 24695268 ER PT J AU Carr, W Polejaeva, E Grome, A Crandall, B LaValle, C Eonta, SE Young, LA AF Carr, Walter Polejaeva, Elena Grome, Anna Crandall, Beth LaValle, Christina Eonta, Stephanie E. Young, Lee Ann TI Relation of Repeated Low-Level Blast Exposure With Symptomology Similar to Concussion SO JOURNAL OF HEAD TRAUMA REHABILITATION LA English DT Article DE blast; concussion; military; survey; symptoms ID TRAUMATIC BRAIN-INJURY; POSTTRAUMATIC-STRESS-DISORDER; OPERATION-IRAQI-FREEDOM; POSTCONCUSSIVE SYMPTOMS; HEAD-INJURY; HEALTH; ASSOCIATION; MECHANISMS; PERSONNEL; SEQUELAE AB Objective: To investigate anecdotal reports suggesting that repeated exposure to low-level explosive blast has myriad health impacts, including an array of neurological effects. Participants: A total of 184 anonymous survey respondents from military and nonmilitary law enforcement populations (135 exposed to occupational blast and 49 controls). Design: Survey of self-reported history of occupational exposure to repeated low-level blast (breaching blast) and symptomology similar to concussion. Results: Findings suggest that number and severity of symptoms increase with history of chronic blast exposure (F = 18.26, P < .001) and that symptoms can interfere with daily activity (t = 2.60, P = .010). Conclusion: Given the prevalence of repeated exposure to blast among some military and civilian law enforcement occupations, the results of this survey study support a role for blast surveillance programs as well as continued research on health impacts of low-level repeated blast exposure. C1 [Carr, Walter; LaValle, Christina; Eonta, Stephanie E.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD 20910 USA. [Polejaeva, Elena] Naval Med Res Ctr, Dept Neurotrauma, Silver Spring, MD USA. [Grome, Anna; Crandall, Beth; Young, Lee Ann] Appl Res Associates, Albuquerque, NM USA. RP Carr, W (reprint author), Walter Reed Army Inst Res, Dept Behav Biol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM walter.s.carr.mil@mail.mil FU Army MOMRP.accelleration.A0908 FX This work was supported by Army MOMRP.accelleration.A0908. NR 37 TC 5 Z9 5 U1 2 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0885-9701 EI 1550-509X J9 J HEAD TRAUMA REHAB JI J. Head Trauma Rehabil. PD JAN-FEB PY 2015 VL 30 IS 1 BP 47 EP 55 DI 10.1097/HTR.0000000000000064 PG 9 WC Clinical Neurology; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA AY8BW UT WOS:000347780400014 PM 24901327 ER PT J AU Krishnaraj, A Norbash, A Allen, B Ellenbogen, PH Kazerooni, EA Thorwarth, W Weinreb, JC AF Krishnaraj, Arun Norbash, Alexander Allen, Bibb, Jr. Ellenbogen, Paul H. Kazerooni, Ella A. Thorwarth, William, Jr. Weinreb, Jeffley C. TI The Impact of the Patient Protection and Affordable Care Act on Radiology: Beyond Reimbursement SO JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY LA English DT Article DE ACR Forum; Affordable Care Act; patient experience; population health; public health; value proposition ID HEALTH; COST; FUTURE; FORUM AB The 2014 ACR Forum focused on the noneconomic implications of the Affordable Care Act on the field of radiology, with specific attention to the importance of the patient experience, the role of radiology in public and population health, and radiology's role in the T effort to lower overall health care costs. The recommendations generated from the Forum seek to inform ACR leadership on the best, strategies to pursue to best prepare the radiology community for the rapidly evolving health care landscape. C1 [Krishnaraj, Arun] Univ Virginia, Charlottesville, VA 22908 USA. [Norbash, Alexander] Boston Univ, Sch Med, Boston, MA 02118 USA. [Allen, Bibb, Jr.] Tripler Army Med Ctr, Birmingham, AL USA. [Ellenbogen, Paul H.] Presbyterian Med Ctr, Dallas, TX USA. [Kazerooni, Ella A.] Univ Michigan, Ann Arbor, MI 48109 USA. [Thorwarth, William, Jr.] ACR, Reston, VA USA. [Weinreb, Jeffley C.] Yale Univ, Sch Med, New Haven, CT USA. RP Krishnaraj, A (reprint author), Univ Virginia Hlth Syst, 1215 Lee St,POB 800170, Charlottesville, VA 22908 USA. EM ak8jj@virginia.edu NR 15 TC 0 Z9 0 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1546-1440 J9 J AM COLL RADIOL JI J. Am. Coll. Radiol. PD JAN PY 2015 VL 12 IS 1 BP 29 EP 33 DI 10.1016/j.jacr.2014.09.035 PG 5 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA AY7NT UT WOS:000347747400011 PM 25557569 ER PT J AU Nirujogi, RS Wright, JD Manda, SS Zhong, J Na, CH Meyerhoff, J Benton, B Jabbour, R Willis, K Kim, MS Pandey, A Sekowski, JW AF Nirujogi, Raja Sekhar Wright, James D., Jr. Manda, Srikanth S. Zhong, Jun Na, Chan Hyun Meyerhoff, James Benton, Bernard Jabbour, Rabih Willis, Kristen Kim, Min-Sik Pandey, Akhilesh Sekowski, Jennifer W. TI Phosphoproteomic analysis reveals compensatory effects in the piriform cortex of VX nerve agent exposed rats SO PROTEOMICS LA English DT Article DE Animal proteomics; Phosphoproteomics; Piriform cortex; Signal transduction; VX ID GLYCOGEN-SYNTHASE KINASE-3; ADRENERGIC-RECEPTOR KINASE; SPLICING FACTORS; SIGNALING PATHWAY; INDUCED SEIZURES; PROTEIN-KINASE; LOCALIZATION; HIPPOCAMPUS; BRAIN; SOMAN AB To gain insights into the toxicity induced by the nerve agent VX, an MS-based phosphoproteomic analysis was carried out on the piriform cortex region of brains from VX-treated rats. Using isobaric tag based TMT labeling followed by titanium dioxide enrichment strategy, we identified 9975 unique phosphosites derived from 3287 phosphoproteins. Temporal changes in the phosphorylation status of peptides were observed over a time period of 24 h in rats exposed to a 1x LD50, intravenous (i.v.) dose with the most notable changes occurring at the 1 h postexposure time point. Five major functional classes of proteins exhibited changes in their phosphorylation status: (i) ion channels/transporters, including ATPases, (ii) kinases/phosphatases, (iii) GTPases, (iv) structural proteins, and (v) transcriptional regulatory proteins. This study is the first quantitative phosphoproteomic analysis of VX toxicity in the brain. Understanding the toxicity and compensatory signaling mechanisms will improve the understanding of the complex toxicity of VX in the brain and aid in the elucidation of novel molecular targets that would be important for development of improved countermeasures. All MS data have been deposited in the ProteomeXchange with identifier PXD001184 (http://proteomecentral.proteomexchange.org/dataset/PXD001184). C1 [Nirujogi, Raja Sekhar; Manda, Srikanth S.] Inst Bioinformat, Bangalore, Karnataka, India. [Nirujogi, Raja Sekhar; Manda, Srikanth S.] Pondicherry Univ, Sch Life Sci, Ctr Bioinformat, Pondicherry, India. [Nirujogi, Raja Sekhar] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA. [Wright, James D., Jr.; Benton, Bernard; Jabbour, Rabih; Sekowski, Jennifer W.] US Army Edgewood Chem Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD USA. [Manda, Srikanth S.; Na, Chan Hyun] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA. [Zhong, Jun; Willis, Kristen] Def Threat Reduct Agcy, Ft Belvoir, VA USA. [Meyerhoff, James] Oakridge Inst Sci & Engn, Oakridge, TN USA. [Kim, Min-Sik; Pandey, Akhilesh] Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD USA. [Pandey, Akhilesh] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA. [Pandey, Akhilesh] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA. RP Sekowski, JW (reprint author), US Army ECBC, 5183 Blackhawk Rd,RDCB DRB D, Aberdeen Proving Ground, MD 21010 USA. EM jennifer.w.sekowski.civ@mail.mil RI Zhong, Jun/D-1662-2010; Kim, Min-Sik/M-3488-2016; OI Zhong, Jun/0000-0003-3148-4143; Kim, Min-Sik/0000-0001-7317-5360; Sekowski, Jennifer/0000-0003-4561-640X FU Joint Science and Technology Office (JSTO); CB-A Division of the Defense Threat Reduction Agency (DTRA); Council of Scientific and Industrial Research (CSIR), Government of India; University Grants Commission (UGC), India FX The authors thank Christopher Phillips, David McCaskey, John Pence, Steven Yee, and Daniel Carmany for their expertise in dosing animals, performing euthanasia, and assisting in the removal and storage of tissues. This work was supported by a grant from the Joint Science and Technology Office (JSTO), CB-A Division of the Defense Threat Reduction Agency (DTRA) (JWS and AP). RSN is a recipient of Senior Research Fellowship from Council of Scientific and Industrial Research (CSIR), Government of India. SSM is a recipient of Senior Research Fellowship from the University Grants Commission (UGC), India. NR 64 TC 2 Z9 2 U1 0 U2 15 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1615-9853 EI 1615-9861 J9 PROTEOMICS JI Proteomics PD JAN PY 2015 VL 15 IS 2-3 SI SI BP 487 EP 499 DI 10.1002/pmic.201400371 PG 13 WC Biochemical Research Methods; Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA AY9UI UT WOS:000347895500028 PM 25403869 ER PT J AU Rezk, PE Zdenka, P Sabnekar, P Kajih, T Mata, DG Wrobel, C Cerasoli, DM Chilukuri, N AF Rezk, Peter E. Zdenka, Pierre Sabnekar, Praveena Kajih, Takwen Mata, David G. Wrobel, Chester Cerasoli, Douglas M. Chilukuri, Nageswararao TI An in vitro and in vivo evaluation of the efficacy of recombinant human liver prolidase as a catalytic bioscavenger of chemical warfare nerve agents SO DRUG AND CHEMICAL TOXICOLOGY LA English DT Article DE Adenovirus; butyrylcholinesterase; catalytic bioscavenger; chemical warfare nerve agents; human liver prolidase; in vivo delivery ID ORGANOPHOSPHORUS ACID ANHYDROLASE; HUMAN BUTYRYLCHOLINESTERASE; KIDNEY PROLIDASE; INDUCED SEIZURES; SOMAN TOXICITY; PROTECTION; PURIFICATION; SARIN; PYRIDOSTIGMINE; PRETREATMENT AB In this study, we determined the ability of recombinant human liver prolidase to hydrolyze nerve agents in vitro and its ability to afford protection in vivo in mice. Using adenovirus containing the human liver prolidase gene, the enzyme was over expressed by 200- to 300-fold in mouse liver and purified to homogeneity by affinity and gel filtration chromatography. The purified enzyme hydrolyzed sarin, cyclosarin and soman with varying rates of hydrolysis. The most efficient hydrolysis was with sarin, followed by soman and by cyclosarin {apparent k(cat)/K-m [(1.9 +/- 0.3), (1.7 +/- 0.2), and (0.45 +/- 0.04)] x 10(5) M-1 min(-1), respectively}; VX and tabun were not hydrolyzed by the recombinant enzyme. The enzyme hydrolyzed P (+) isomers faster than the P (+) isomers. The ability of recombinant human liver prolidase to afford 24 hour survival against a cumulative dose of 2 x LD50 of each nerve agent was investigated in mice. Compared to mice injected with a control virus, mice injected with the prolidase expressing virus contained (29 +/- 7)-fold higher levels of the enzyme in their blood on day 5. Challenging these mice with two consecutive 1 x LD50 doses of sarin, cyclosarin, and soman resulted in the death of all animals within 5 to 8 min from nerve agent toxicity. In contrast, mice injected with the adenovirus expressing mouse butyrylcholinesterase, an enzyme which is known to afford protection in vivo, survived multiple 1 x LD50 challenges of these nerve agents and displayed no signs of toxicity. These results suggest that, while prolidase can hydrolyze certain G-type nerve agents in vitro, the enzyme does not offer 24 hour protection against a cumulative dose of 2 x LD50 of G-agents in mice in vivo. C1 [Rezk, Peter E.; Zdenka, Pierre; Sabnekar, Praveena; Kajih, Takwen; Mata, David G.; Wrobel, Chester; Cerasoli, Douglas M.; Chilukuri, Nageswararao] US Army Med Res Inst Chem Def, Physiol & Immunol Branch, Div Res, Aberdeen Proving Ground, MD 21010 USA. RP Chilukuri, N (reprint author), US Army Med Res Inst Chem Def, Physiol & Immunol Branch, Div Res, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM Nageswararao.chilukuri.civ@mail.mil FU Defense Threat Reduction Agency-Joint Science and Technology Office, Medical ST Division [D0003_09_RC_C] FX This research was supported by the Defense Threat Reduction Agency (Project ID: D0003_09_RC_C)-Joint Science and Technology Office, Medical S&T Division. The views expressed in this manuscript are those of the author(s) and do not reflect the official policy of the Department of Army, Department of Defense, or the U.S. Government. The experimental protocol was approved by the Animal Care and Use Committee of the US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD and all procedures were conducted in accordance with the principles stated in the Guide for the Care and Use of Laboratory Animals (National Research Council), and the Animal Welfare Act of 1966 (P.L. 89-544), as amended. The authors are grateful to Dr. John McDonough, USAMRICD, for help with the animal experiments and suggestions with the manuscript. NR 39 TC 4 Z9 4 U1 1 U2 27 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0148-0545 EI 1525-6014 J9 DRUG CHEM TOXICOL JI Drug Chem. Toxicol. PD JAN PY 2015 VL 38 IS 1 BP 37 EP 43 DI 10.3109/01480545.2014.900071 PG 7 WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy; Toxicology SC Chemistry; Pharmacology & Pharmacy; Toxicology GA AY0XE UT WOS:000347316800006 PM 24641262 ER PT J AU Miller, RS Weaver, LK Bahraini, N Churchill, S Price, RC Skiba, V Caviness, J Mooney, S Hetzell, B Liu, J Deru, K Ricciardi, R Fracisco, S Close, NC Surrett, GW Bartos, C Ryan, M Brenner, LA AF Miller, R. Scott Weaver, Lindell K. Bahraini, Nazanin Churchill, Susan Price, Robert C. Skiba, Virginia Caviness, James Mooney, Scott Hetzell, Brian Liu, Jun Deru, Kayla Ricciardi, Richard Fracisco, Susan Close, Nicole C. Surrett, Gerald W. Bartos, Corinna Ryan, Margaret Brenner, Lisa A. CA HOPPS Trial Team TI Effects of Hyperbaric Oxygen on Symptoms and Quality of Life Among Service Members With Persistent Postconcussion Symptoms A Randomized Clinical Trial SO JAMA INTERNAL MEDICINE LA English DT Article ID TRAUMATIC BRAIN-INJURY; POST-CONCUSSION SYNDROME; POSTTRAUMATIC-STRESS-DISORDER; MILD TBI; MILITARY; BLAST; RELIABILITY; COMPLAINTS; QUESTIONNAIRE; MANAGEMENT AB IMPORTANCE Improvement has been anecdotally observed in patients with persistent postconcussion symptoms (PCS) after mild traumatic brain injury following treatment with hyperbaric oxygen (HBO). The effectiveness of HBO as an adjunctive treatment for PCS is unknown to date. OBJECTIVES To compare the safety of and to estimate the efficacy for symptomatic outcomes from standard PCS care alone, care supplemented with HBO, or a sham procedure. DESIGN, SETTING, AND PARTICIPANTS Multicenter, double-blind, sham-controlled clinical trial of 72 military service members with ongoing symptoms at least 4 months after mild traumatic brain injury enrolled at military hospitals in Colorado, North Carolina, California, and Georgia between April 26, 2011, and August 24, 2012. Assessments occurred before randomization, at the midpoint, and within 1 month after completing the interventions. INTERVENTIONS Routine PCS care was provided in specialized clinics. In addition, participants were randomized 1: 1: 1 to 40 HBO sessions administered at 1.5 atmospheres absolute (ATA), 40 sham sessions consisting of room air at 1.2 ATA, or no supplemental chamber procedures. MAIN OUTCOMES AND MEASURES The Rivermead Post-Concussion Symptoms Questionnaire (RPQ) served as the primary outcome measure. A change score of at least 2 points on the RPQ-3 subscale (range, 0-12) was defined as clinically significant. Change scores from baseline were calculated for the RPQ-3 and for the total RPQ. Secondary measures included additional patient-reported outcomes and automated neuropsychometric testing. RESULTS On average, participants had sustained 3 lifetime mild traumatic brain injuries; the most recent occurred 23 months before enrollment. No differences were observed between groups for improvement of at least 2 points on the RPQ-3 subscale (25% in the no intervention group, 52% in the HBO group, and 33% in the sham group; P=.24). Compared with the no intervention group (mean change score, 0.5; 95% CI, -4.8 to 5.8; P=.91), both groups undergoing supplemental chamber procedures showed improvement in symptoms on the RPQ (mean change score, 5.4; 95% CI, -0.5 to 11.3; P=.008 in the HBO group and 7.0; 95% CI, 1.0-12.9; P=.02 in the sham group). No difference between the HBO group and the sham group was observed (P=.70). Chamber sessions were well tolerated. CONCLUSIONS AND RELEVANCE Among service members with persistent PCS, HBO showed no benefits over sham compressions. Both intervention groups demonstrated improved outcomes compared with PCS care alone. This finding suggests that the observed improvements were not oxygen mediated but may reflect nonspecific improvements related to placebo effects. C1 [Miller, R. Scott; Fracisco, Susan] US Army Med Mat Dev Act, Ft Detrick, MD USA. [Weaver, Lindell K.] Univ Utah, Sch Med, Dept Med, Salt Lake City, UT USA. [Weaver, Lindell K.; Churchill, Susan; Deru, Kayla] LDS Hosp, Dept Hyperbar Med, Salt Lake City, UT USA. [Bahraini, Nazanin; Brenner, Lisa A.] Univ Colorado, Aurora, CO USA. [Bahraini, Nazanin; Brenner, Lisa A.] Mental Illness Res Educ & Clin Ctr, Vet Integrated Serv Network 19, Denver, CO USA. [Price, Robert C.; Surrett, Gerald W.] Evans Army Community Hosp, Ft Carson, CO USA. [Skiba, Virginia; Bartos, Corinna] Naval Hosp Camp Lejeune, Camp Lejeune, NC USA. [Caviness, James; Ryan, Margaret] Naval Hosp Camp Pendleton, Camp Pendleton, CA USA. [Mooney, Scott] Eisenhower Army Med Ctr, Ft Gordon, GA USA. [Hetzell, Brian; Liu, Jun] Pharmaceut Prod Dev LLC, Wilmington, NC USA. [Ricciardi, Richard] Def Ctr Excellence Psychol Hlth & Traumat Brain I, Silver Spring, MD USA. [Close, Nicole C.] EmpiriStat Inc, Mt Airy, MD USA. RP Miller, RS (reprint author), Uniformed Serv Univ Hlth Sci, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM robert.s.miller@us.army.mil FU Defense Health Program FX The HOPPS trial was funded by the Defense Health Program and was managed by the US Army Medical Materiel Development Activity. The Naval Health Research Center and Army Contracting Command contracted support throughout this trial. NR 38 TC 20 Z9 20 U1 1 U2 5 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6106 EI 2168-6114 J9 JAMA INTERN MED JI JAMA Intern. Med. PD JAN PY 2015 VL 175 IS 1 BP 43 EP 52 DI 10.1001/jamainternmed.2014.5479 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA AY1BM UT WOS:000347328500013 PM 25401463 ER PT J AU Hoge, C Jonas, WB AF Hoge, CharlesW. Jonas, Wayne B. TI The Ritual of Hyperbaric Oxygen and Lessons for the Treatment of Persistent Postconcussion Symptoms in Military Personnel SO JAMA INTERNAL MEDICINE LA English DT Editorial Material ID POSTTRAUMATIC-STRESS-DISORDER; COMBAT C1 [Hoge, CharlesW.] Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Jonas, Wayne B.] Samueli Inst, Alexandria, VA USA. RP Hoge, C (reprint author), Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD 20910 USA. EM charles.hoge@us.army.mil NR 7 TC 3 Z9 3 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6106 EI 2168-6114 J9 JAMA INTERN MED JI JAMA Intern. Med. PD JAN PY 2015 VL 175 IS 1 BP 53 EP 54 DI 10.1001/jamainternmed.2014.3375 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA AY1BM UT WOS:000347328500014 PM 25401214 ER PT J AU Okulicz, JF Le, TD Agan, BK Camargo, JF Landrum, ML Wright, E Dolan, MJ Ganesan, A Ferguson, TM Smith, DM Richman, DD Little, SJ Clark, RA He, WJ Ahuja, SK AF Okulicz, Jason F. Le, Tuan D. Agan, Brian K. Camargo, Jose F. Landrum, Michael L. Wright, Edwina Dolan, Matthew J. Ganesan, Anuradha Ferguson, Tomas M. Smith, Davey M. Richman, Douglas D. Little, Susan J. Clark, Robert A. He, Weijing Ahuja, Sunil K. TI Influence of the Timing of Antiretroviral Therapy on the Potential for Normalization of Immune Status in Human Immunodeficiency Virus 1-Infected Individuals SO JAMA INTERNAL MEDICINE LA English DT Article ID HIV-INFECTED PATIENTS; T-CELL COUNTS; CLINICAL-OUTCOMES; CD4 COUNT; AIDS; RESTORATION; RESERVOIRS; INITIATION; RECOVERY; HAART AB IMPORTANCE In individuals with human immunodeficiency virus 1 (HIV-1) infection who are receiving antiretroviral therapy (ART), factors that promote full immune recovery are not well characterized. OBJECTIVE To investigate the influence of the timing of ART relative to HIV-1 infection on normalization of CD4(+) T-cell counts, AIDS risk, and immune function. DESIGN, SETTING, AND PARTICIPANTS Participants in the observational US Military HIV Natural History Study with documented estimated dates of seroconversion (EDS) who achieved virologic suppression with ART were evaluated. Markers indicative of immune activation, dysfunction, and responsiveness were determined. Responses to hepatitis B virus (HBV) vaccine, an indicator of in vivo immune function, were also assessed. The timing of ART was indexed to the EDS and/or entry into the cohort. The CD4(+) counts in HIV-1-uninfected populations were surveyed. MAIN OUTCOMES AND MEASURES Normalization of CD4(+) counts to 900 cells/mu L or higher, AIDS development, HBV vaccine response, as well as T-cell activation, dysfunction, and responsiveness. RESULTS The median CD4(+) count in HIV-1-uninfected populations was approximately 900 cells/mu L. Among 1119 HIV-1-infected participants, CD4(+) normalization was achieved in 38.4% vs 28.3% of those initiating ART within 12 months vs after 12 months from the EDS (P=.001). Incrementally higher CD4(+) recovery (<500, 500-899, and >= 900 cells/mu L) was associated with stepwise decreases in AIDS risk and reversion of markers of immune activation, dysfunction, and responsiveness to levels approximating those found in HIV-1-uninfected persons. Participants with CD4(+) counts of 500 cells/mu L or higher at study entry (adjusted odds ratio [aOR], 2.00; 95% CI, 1.51-2.64; P<.001) or ART initiation (aOR, 4.08; 95% CI, 3.14-5.30; P<.001) had significantly increased CD4(+) normalization rates compared with other participants. However, even among individuals with a CD4(+) count of 500 cells/mu L or higher at both study entry and before ART, the odds of CD4(+) normalization were 80% lower in those initiating ART after 12 months from the EDS and study entry (aOR, 0.20; 95% CI, 0.07-0.53; P=001). Initiation of ART within 12 months of EDS vs later was associated with a significantly lower risk of AIDS (7.8% vs 15.3%; P=.002), reduced T-cell activation (percent CD4(+) HLA-DR+ effector memory T cells, 12.0% vs 15.6%; P=.03), and increased responsiveness to HBV vaccine (67.9% vs 50.9%; P=.07). CONCLUSIONS AND RELEVANCE Deferral of ART beyond 12 months of the EDS diminishes the likelihood of restoring immunologic health in HIV-1-infected individuals. C1 [Okulicz, Jason F.; Agan, Brian K.; Landrum, Michael L.; Ganesan, Anuradha; Ferguson, Tomas M.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Okulicz, Jason F.] San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX USA. [Le, Tuan D.; Camargo, Jose F.; Clark, Robert A.; He, Weijing; Ahuja, Sunil K.] South Texas Vet Hlth Care Syst, Vet Affairs VA Res Ctr AIDS & HIV Infect 1, San Antonio, TX 78229 USA. [Le, Tuan D.; Camargo, Jose F.; Clark, Robert A.; He, Weijing; Ahuja, Sunil K.] South Texas Vet Hlth Care Syst, Vet Affairs Ctr Personalized Med, San Antonio, TX 78229 USA. [Le, Tuan D.; Camargo, Jose F.; Clark, Robert A.; He, Weijing; Ahuja, Sunil K.] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA. [Agan, Brian K.] Henry M Jackson Fdn Adv Mil Med Inc, Bethesda, MD USA. [Landrum, Michael L.] Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. [Wright, Edwina] Alfred Hosp, Dept Infect Dis, Melbourne, Vic, Australia. [Wright, Edwina] Burnet Inst, Melbourne, Vic, Australia. [Wright, Edwina] Monash Univ, Dept Infect Dis, Melbourne, Vic 3004, Australia. [Dolan, Matthew J.] Mil Med Inc, Henry M Jackson Fdn Adv, Lackland AFB, TX USA. [Ganesan, Anuradha] Walter Reed Natl Mil Med Ctr, Infect Dis Serv, Bethesda, MD USA. [Ferguson, Tomas M.] Tripler Army Med Ctr, Infect Dis Serv, Honolulu, HI 96859 USA. [Smith, Davey M.; Richman, Douglas D.; Little, Susan J.] Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA. [Smith, Davey M.; Richman, Douglas D.] Vet Affairs San Diego Healthcare Syst, San Diego, CA USA. [Richman, Douglas D.] Univ Calif San Diego, Dept Pathol, San Diego, CA 92103 USA. [Ahuja, Sunil K.] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, San Antonio, TX 78229 USA. RP Ahuja, SK (reprint author), South Texas Vet Hlth Care Syst, Vet Affairs VA Res Ctr AIDS & HIV Infect 1, 7400 Merton Minter Blvd,Room W200, San Antonio, TX 78229 USA. EM ahujas@uthscsa.edu OI Agan, Brian/0000-0002-5114-1669 FU Veterans Affairs (VA) Research Center [IP1 CX000875-01A1]; National Institutes of Health (NIH) [R37AI046326]; Doris Duke Distinguished Clinical Scientist Award; VA MERIT award; Elizabeth Glaser Pediatric AIDS Foundation; Burroughs Wellcome Clinical Scientist Award; Max and Minnie Tomerlin Voelcker Fund; NIH [UL1TR001120, DA034978, AI43638, AI69432, MH62512, AI74621, MH097520, AI077304, AI007384, AI080193, AI106039, AI096113]; VA Career Development Award-2; National Health and Medical Research Council of Australia; Infectious Disease Clinical Research Program (IDCRP); Uniformed Services University of the Health Sciences [IDCRP-000-03]; National Institute of Allergy and Infectious Diseases; International AIDS Vaccine Initiative [DMS0714991] FX The work was supported by the Veterans Affairs (VA) Research Center for AIDS and HIV Infection and VA Center for Personalized Medicine grant IP1 CX000875-01A1, National Institutes of Health (NIH) MERIT grant R37AI046326, and the Doris Duke Distinguished Clinical Scientist Award to Dr Ahuja. Dr Ahuja is also supported by a VA MERIT award, the Elizabeth Glaser Pediatric AIDS Foundation, the Burroughs Wellcome Clinical Scientist Award in Translational Research and the Senior Scholar Award from the Max and Minnie Tomerlin Voelcker Fund. This work was also supported by NIH grant UL1TR001120 (Clinical and Translational Science Award). Dr Le was supported by a VA Career Development Award-2. DrWright was supported by an Early Career Fellowship from the National Health and Medical Research Council of Australia. Support for this work was also provided in part by the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense program executed through the Uniformed Services University of the Health Sciences (IDCRP-000-03). This project has been funded in part with federal funds from the National Institute of Allergy and Infectious Diseases, NIH, under Inter-Agency Agreement Y1-AI-5072. Drs Smith, Richman, and Little were supported by NIH grants DA034978, AI43638, AI69432, MH62512, AI74621, MH097520, AI077304, AI007384, AI080193, AI106039, and AI096113 and the International AIDS Vaccine Initiative grant DMS0714991. NR 34 TC 24 Z9 24 U1 0 U2 3 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6106 EI 2168-6114 J9 JAMA INTERN MED JI JAMA Intern. Med. PD JAN PY 2015 VL 175 IS 1 BP 88 EP 99 DI 10.1001/jamainternmed.2014.4010 PG 12 WC Medicine, General & Internal SC General & Internal Medicine GA AY1BM UT WOS:000347328500019 PM 25419650 ER PT J AU Herrera, RA AF Herrera, Ricardo A. TI "[T]he zealous activity of Capt. Lee": Light-Horse Harry Lee and Petite Guerre SO JOURNAL OF MILITARY HISTORY LA English DT Article AB The Continental Army entrusted many of its junior officers with a great degree of responsibility and autonomy. Captain Henry Lee's role in commanding a vital foraging operation in Delaware and Maryland for the Main Army at Valley Forge in February and March 1778 sheds light on the role of a company-grade officer within the broader framework of petite guerre. Lee demonstrated his ability at planning and executing autonomous operations and proved himself a capable, thoughtful, and energetic officer in an important, but overlooked expedition that reveals something of the important operational middle ground occupied by American company-grade light officers. C1 US Army Command & Gen Staff Coll, Sch Adv Mil Studies, Ft Leavenworth, KS 66027 USA. RP Herrera, RA (reprint author), US Army Command & Gen Staff Coll, Sch Adv Mil Studies, Ft Leavenworth, KS 66027 USA. NR 129 TC 0 Z9 0 U1 0 U2 1 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD JAN PY 2015 VL 79 IS 1 BP 9 EP 36 PG 28 WC History SC History GA AY0ED UT WOS:000347269600001 ER PT J AU Echevarria, AJ AF Echevarria, Antdio J. TI The Great War Dawning: Germany and its Army at the Start of World War I. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Echevarria, Antdio J.] US Army War Coll, Carlisle, PA 17013 USA. RP Echevarria, AJ (reprint author), US Army War Coll, Carlisle, PA 17013 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD JAN PY 2015 VL 79 IS 1 BP 228 EP 229 PG 2 WC History SC History GA AY0ED UT WOS:000347269600034 ER PT J AU Connelly, DB AF Connelly, Donald B. TI The Impact of the First World War on US Policymakers: American Strategic and Foreign Policy Formulation, 1938-1942 SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Connelly, Donald B.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. RP Connelly, DB (reprint author), US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD JAN PY 2015 VL 79 IS 1 BP 246 EP 247 PG 2 WC History SC History GA AY0ED UT WOS:000347269600048 ER PT J AU Fischer, JR AF Fischer, Joseph R. TI Dog Company: The Boys of Pointe die Hoc: The Rangers Who Accomplished D-Day's Toughest Mission and Led the Way Across Europe SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Fischer, Joseph R.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. RP Fischer, JR (reprint author), US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD JAN PY 2015 VL 79 IS 1 BP 252 EP 254 PG 3 WC History SC History GA AY0ED UT WOS:000347269600053 ER PT J AU Rafuse, ES AF Rafuse, Ethan S. TI Misalliance: Ngo Dinh Diem, the United States, and the Fate of South Vietnam SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Rafuse, Ethan S.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. RP Rafuse, ES (reprint author), US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD JAN PY 2015 VL 79 IS 1 BP 259 EP 260 PG 2 WC History SC History GA AY0ED UT WOS:000347269600057 ER PT J AU Cai, YY Postnikova, EN Bernbaum, JG Yu, SQ Mazur, S Deiuliis, NM Radoshitzky, SR Lackemeyer, MG McCluskey, A Robinson, PJ Haucke, V Wahl-Jensen, V Bailey, AL Lauck, M Friedrich, TC O'Connor, DH Goldberg, TL Jahrling, PB Kuhna, JH AF Cai, Yingyun Postnikova, Elena N. Bernbaum, John G. Yu, Shuiqing Mazur, Steven Deiuliis, Nicole M. Radoshitzky, Sheli R. Lackemeyer, Matthew G. McCluskey, Adam Robinson, Phillip J. Haucke, Volker Wahl-Jensen, Victoria Bailey, Adam L. Lauck, Michael Friedrich, Thomas C. O'Connor, David H. Goldberg, Tony L. Jahrling, Peter B. Kuhna, Jens H. TI Simian Hemorrhagic Fever Virus Cell Entry Is Dependent on CD163 and Uses a Clathrin-Mediated Endocytosis-Like Pathway SO JOURNAL OF VIROLOGY LA English DT Article ID RESPIRATORY SYNDROME VIRUS; EQUINE ARTERITIS VIRUS; HOST-CELLS; ENVELOPE PROTEINS; VESICLE FORMATION; DISULFIDE BONDS; INFECTION; GENOME; RNA; GLYCOPROTEIN AB Simian hemorrhagic fever virus (SHFV) causes a severe and almost uniformly fatal viral hemorrhagic fever in Asian macaques but is thought to be nonpathogenic for humans. To date, the SHFV life cycle is almost completely uncharacterized on the molecular level. Here, we describe the first steps of the SHFV life cycle. Our experiments indicate that SHFV enters target cells by low-pH-dependent endocytosis. Dynamin inhibitors, chlorpromazine, methyl-beta-cyclodextrin, chloroquine, and concanamycin A dramatically reduced SHFV entry efficiency, whereas the macropinocytosis inhibitors EIPA, blebbistatin, and wortmannin and the caveolin-mediated endocytosis inhibitors nystatin and filipin III had no effect. Furthermore, overexpression and knockout study and electron microscopy results indicate that SHFV entry occurs by a dynamin-dependent clathrin-mediated endocytosis-like pathway. Experiments utilizing latrunculin B, cytochalasin B, and cytochalasin D indicate that SHFV does not hijack the actin polymerization pathway. Treatment of target cells with proteases (proteinase K, papain, alpha-chymotrypsin, and trypsin) abrogated entry, indicating that the SHFV cell surface receptor is a protein. Phospholipases A2 and D had no effect on SHFV entry. Finally, treatment of cells with antibodies targeting CD163, a cell surface molecule identified as an entry factor for the SHFV-related porcine reproductive and respiratory syndrome virus, diminished SHFV replication, identifying CD163 as an important SHFV entry component. IMPORTANCE Simian hemorrhagic fever virus (SHFV) causes highly lethal disease in Asian macaques resembling human illness caused by Ebola or Lassa virus. However, little is known about SHFV's ecology and molecular biology and the mechanism by which it causes disease. The results of this study shed light on how SHFV enters its target cells. Using electron microscopy and inhibitors for various cellular pathways, we demonstrate that SHFV invades cells by low-pH-dependent, actin-independent endocytosis, likely with the help of a cellular surface protein. C1 [Cai, Yingyun; Postnikova, Elena N.; Bernbaum, John G.; Yu, Shuiqing; Mazur, Steven; Deiuliis, Nicole M.; Lackemeyer, Matthew G.; Wahl-Jensen, Victoria; Jahrling, Peter B.; Kuhna, Jens H.] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD 21702 USA. [Radoshitzky, Sheli R.] US Army, Med Res Inst Infect Dis, Frederick, MD USA. [McCluskey, Adam] Univ Newcastle, Sch Environm & Life Sci, Dept Chem, Ctr Chem Biol, Callaghan, NSW 2308, Australia. [Robinson, Phillip J.] Univ Sydney, Cell Signaling Unit, Childrens Med Res Inst, Sydney, NSW 2006, Australia. [Haucke, Volker] Leibniz Inst Mol Pharmacol, Berlin, Germany. [Bailey, Adam L.; Lauck, Michael; Friedrich, Thomas C.; O'Connor, David H.; Goldberg, Tony L.] Wisconsin Natl Primate Res Ctr, Madison, WI USA. RP Kuhna, JH (reprint author), NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD 21702 USA. EM kuhnjens@mail.nih.gov RI Kuhn, Jens H./B-7615-2011; Robinson, Phillip/G-4008-2011; OI Kuhn, Jens H./0000-0002-7800-6045; Robinson, Phillip/0000-0002-7878-0313; Postnikova, Elena/0000-0002-0275-2148; Deiuliis, Nicole/0000-0002-8923-0288; McCluskey, Adam/0000-0001-7125-863X; Haucke, Volker/0000-0003-3119-6993 FU NIAID [HHSN272200700016I] FX Y.C., E.N.P., J.G.B., V.W.-J., and J.H.K. performed this work as employees of Tunnell Government Services, Inc., N.M.D. as an employee of MRI Global, and M.G.L. as an employee of Lovelace Respiratory Research Institute, all subcontractors of Battelle Memorial Institute, and S.Y. as an emploee of Battelle Memorial Institute, all under Battelle's prime contract with NIAID (contract no. HHSN272200700016I). NR 73 TC 10 Z9 12 U1 2 U2 17 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X EI 1098-5514 J9 J VIROL JI J. Virol. PD JAN PY 2015 VL 89 IS 1 BP 844 EP 856 DI 10.1128/JVI.02697-14 PG 13 WC Virology SC Virology GA AX8RL UT WOS:000347176100071 PM 25355889 ER PT J AU Lesho, EP AF Lesho, Emil P. TI US Ebola Case: An Example of the Misuse of Antibiotics and a Reminder for Better Stewardship SO MAYO CLINIC PROCEEDINGS LA English DT Letter C1 Walter Reed Army Inst Res, Silver Spring, MD USA. RP Lesho, EP (reprint author), Walter Reed Army Inst Res, Silver Spring, MD USA. NR 7 TC 1 Z9 1 U1 1 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0025-6196 EI 1942-5546 J9 MAYO CLIN PROC JI Mayo Clin. Proc. PD JAN PY 2015 VL 90 IS 1 BP 161 EP 161 DI 10.1016/j.mayocp.2014.11.001 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA AY2ZW UT WOS:000347455400024 PM 25572203 ER PT J AU Twenhafel, NA Shaia, CI Bunton, TE Shamblin, JD Wollen, SE Pitt, LM Sizemore, DR Ogg, MM Johnston, SC AF Twenhafel, N. A. Shaia, C. I. Bunton, T. E. Shamblin, J. D. Wollen, S. E. Pitt, L. M. Sizemore, D. R. Ogg, M. M. Johnston, S. C. TI Experimental Aerosolized Guinea Pig-Adapted Zaire Ebolavirus (Variant: Mayinga) Causes Lethal Pneumonia in Guinea Pigs SO VETERINARY PATHOLOGY LA English DT Article DE aerosol; alveolar macrophages; animal model; ebolavirus; filovirus; guinea pig; lungs; Mayinga ID FILOVIRUS INFECTIONS; VIRUS VIRULENCE; MACAQUES AB Eight guinea pigs were aerosolized with guinea pig-adapted Zaire ebolavirus (variant: Mayinga) and developed lethal interstitial pneumonia that was distinct from lesions described in guinea pigs challenged subcutaneously, nonhuman primates challenged by the aerosol route, and natural infection in humans. Guinea pigs succumbed with significant pathologic changes primarily restricted to the lungs. Intracytoplasmic inclusion bodies were observed in many alveolar macrophages. Perivasculitis was noted within the lungs. These changes are unlike those of documented subcutaneously challenged guinea pigs and aerosolized filoviral infections in nonhuman primates and human cases. Similar to findings in subcutaneously challenged guinea pigs, there were only mild lesions in the liver and spleen. To our knowledge, this is the first report of aerosol challenge of guinea pigs with guinea pig-adapted Zaire ebolavirus (variant: Mayinga). Before choosing this model for use in aerosolized ebolavirus studies, scientists and pathologists should be aware that aerosolized guinea pig-adapted Zaire ebolavirus (variant: Mayinga) causes lethal pneumonia in guinea pigs. C1 [Twenhafel, N. A.; Shaia, C. I.; Bunton, T. E.; Shamblin, J. D.; Wollen, S. E.; Pitt, L. M.; Sizemore, D. R.; Ogg, M. M.; Johnston, S. C.] US Army Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Twenhafel, NA (reprint author), US Army Med Res Inst Infect Dis, Div Pathol, 1425 Porter St, Ft Detrick, MD 21702 USA. EM nancy.twenhafel@us.army.mil NR 12 TC 9 Z9 9 U1 2 U2 4 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0300-9858 EI 1544-2217 J9 VET PATHOL JI Vet. Pathol. PD JAN PY 2015 VL 52 IS 1 BP 21 EP 25 DI 10.1177/0300985814535612 PG 5 WC Pathology; Veterinary Sciences SC Pathology; Veterinary Sciences GA AY0QC UT WOS:000347300600004 PM 24829285 ER PT J AU van Beers, PRM Kouznetsova, VG Geers, MGD Tschopp, MA McDowell, DL AF van Beers, P. R. M. Kouznetsova, V. G. Geers, M. G. D. Tschopp, M. A. McDowell, D. L. TI A multiscale model of grain boundary structure and energy: From atomistics to a continuum description SO ACTA MATERIALIA LA English DT Article DE Grain boundary structure; Grain boundary energy; Multiscale; Atomistic-to-continuum modeling ID GRADIENT CRYSTAL PLASTICITY; TRANSMISSION ELECTRON-MICROSCOPY; SYMMETRICAL TILT BOUNDARIES; CENTERED-CUBIC METALS; FRANK-BILBY EQUATION; FCC METALS; UNIT MODEL; DISLOCATION-STRUCTURE; ELASTOPLASTIC THEORY; DISCLINATION FIELDS AB Grain boundaries play an important role in the mechanical and physical properties of polycrystalline metals. While continuum macroscale simulations are appropriate for modeling grain boundaries in coarse-grained materials, only atornistic simulations provide access to the details of the grain boundary (GB) structure and energy. Hence, a multiscale description is required to capture these GB details. The objective of this paper is to consolidate various approaches for characterizing grain boundaries in an effort to develop a multiscale model of the initial GB structure and energy. The technical approach is detailed using various < 100 >, < 110 > and < 111 > symmetric tilt grain boundaries in copper and aluminum. Characteristic features are: (i) GB energies obtained from atomistic simulations and boundary period vectors from crystallography, (ii) structural unit and dislocation descriptions of the GB structure and (iii) the Frank Bilby equation to determine the dislocation content. The proposed approach defines an intrinsic net defect density scalar that is used to accurately compute the GB energy for these GB systems. The significance of the present work is that the developed atomistic-to-continuum approach is suitable for realistically inserting the initial GB structure and energy into continuum level frameworks. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [van Beers, P. R. M.; Kouznetsova, V. G.; Geers, M. G. D.] Eindhoven Univ Technol, Dept Mech Engn, NL-5600 MB Eindhoven, Netherlands. [Tschopp, M. A.] US Army, Ballist Res Lab, Aberdeen Proving Ground, MD 21005 USA. [McDowell, D. L.] Georgia Inst Technol, Woodruff Sch Mech Engn, Atlanta, GA 30332 USA. RP Kouznetsova, VG (reprint author), Eindhoven Univ Technol, Dept Mech Engn, POB 513, NL-5600 MB Eindhoven, Netherlands. EM v.g.kouznetsova@tue.nl RI Kouznetsova, Varvara /D-4663-2016; OI Kouznetsova, Varvara /0000-0003-0113-6471; Tschopp, Mark/0000-0001-8471-5035 FU Dutch Technology Foundation STW; Ministry of Economic Affairs [10109] FX This research is supported by the Dutch Technology Foundation STW, which is the applied science division of NWO, and the Technology Program of the Ministry of Economic Affairs under Project Nr. 10109. D.L.M. is grateful for the support of the Carter N. Paden, Jr. Distinguished Chair in Metals Processing. NR 85 TC 14 Z9 14 U1 3 U2 45 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6454 EI 1873-2453 J9 ACTA MATER JI Acta Mater. PD JAN 1 PY 2015 VL 82 BP 513 EP 529 DI 10.1016/j.actamat.2014.08.045 PG 17 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA AX6FE UT WOS:000347017800048 ER PT J AU Wu, FX Lee, JT Nitta, N Kim, H Borodin, O Yushin, G AF Wu, Feixiang Lee, Jung Tae Nitta, Naoki Kim, Hyea Borodin, Oleg Yushin, Gleb TI Lithium Iodide as a Promising Electrolyte Additive for Lithium-Sulfur Batteries: Mechanisms of Performance Enhancement SO ADVANCED MATERIALS LA English DT Article ID LI-S BATTERIES; POLY(ETHYLENE OXIDE); CATHODE MATERIALS; ION BATTERIES; COMPOSITE; GRAPHENE; DECOMPOSITION; TEMPERATURE; STABILITY; SPHERES C1 [Wu, Feixiang; Lee, Jung Tae; Nitta, Naoki; Kim, Hyea; Yushin, Gleb] Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA. [Wu, Feixiang] Cent S Univ, Sch Met & Environm, Changsha 410083, Peoples R China. [Kim, Hyea] Sila Nanotechnol Inc, Atlanta, GA 30332 USA. [Borodin, Oleg] Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA. RP Yushin, G (reprint author), Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA. EM yushin@gatech.edu RI Yushin, Gleb/B-4529-2013; Borodin, Oleg/B-6855-2012 OI Yushin, Gleb/0000-0002-3274-9265; Borodin, Oleg/0000-0002-9428-5291 FU Army Research Office (ARO) [W911NF-12-1-0259]; China Scholarship Council [201206370083]; National Science Foundation [DMR 0922776] FX This work was partially supported by the Army Research Office (ARO grant W911NF-12-1-0259). Wu fellowship was supported by China Scholarship Council (No. 201206370083). The TEM used in this work was purchased using support from the National Science Foundation (project DMR 0922776). The authors thank B. Zdyrko from Sila Nanotechnologies, Inc. for helpful discussions. NR 43 TC 47 Z9 48 U1 38 U2 297 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 0935-9648 EI 1521-4095 J9 ADV MATER JI Adv. Mater. PD JAN PY 2015 VL 27 IS 1 BP 101 EP 108 DI 10.1002/adma.201404194 PG 8 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA AX9RL UT WOS:000347239600014 PM 25367318 ER PT J AU Hebert, JJ Fritz, JM Thackeray, A Koppenhaver, SL Teyhen, D AF Hebert, Jeffrey J. Fritz, Julie M. Thackeray, Anne Koppenhaver, Shane L. Teyhen, Deydre TI Early multimodal rehabilitation following lumbar disc surgery: a randomised clinical trial comparing the effects of two exercise programmes on clinical outcome and lumbar multifidus muscle function SO BRITISH JOURNAL OF SPORTS MEDICINE LA English DT Article ID LOW-BACK-PAIN; CROSS-SECTIONAL AREA; TRANSVERSUS ABDOMINIS; POSTOPERATIVE MANAGEMENT; ACTIVITY RESTRICTIONS; IMPORTANT DIFFERENCE; PARASPINAL MUSCLES; LOCAL DENERVATION; TRUNK MUSCLES; DRAWING-IN AB Background The optimal components of postoperative exercise programmes following single-level lumbar discectomy have not been identified. Facilitating lumbar multifidus (LM) function after discectomy may improve postoperative recovery. The aim of this study was to compare the clinical and muscle function outcomes of patients randomised to receive early multimodal rehabilitation following lumbar discectomy consisting of exercises targeting specific trunk muscles including the LM or general trunk exercises. Methods We included participants aged 18 to 60 years who were scheduled to undergo single-level lumbar discectomy. After two postoperative weeks, participants were randomly assigned to receive an 8-week multimodal exercise programme including either general or specific trunk exercises. The primary outcome was pain-related disability (Oswestry Index). Secondary outcomes included low back and leg pain intensity (0-10 numeric pain rating scale), global change, sciatica frequency, sciatica bothersomeness and LM function measured with real-time ultrasound imaging. Treatment effects 10 weeks and 6 months after surgery were estimated with linear mixed models. Results 61 participants were randomised to receive a general trunk (n=32) or specific (n=29) exercise programme. There were no between-group differences in clinical or muscle function outcomes. Participants in both groups experienced improvements in most outcome measures. Conclusions Following lumbar discectomy, multimodal rehabilitation programmes comprising specific or general trunk exercises have similar effects on clinical and muscle function outcomes. Local factors such as the individual patient characteristics identified by specific assessment findings, clinician expertise and patient preferences should direct therapy selection when considering the types of exercises tested in this trial for inclusion in rehabilitation programmes following lumbar disc surgery. C1 [Hebert, Jeffrey J.; Koppenhaver, Shane L.] Murdoch Univ, Sch Psychol & Exercise Sci, Murdoch, WA 6150, Australia. [Fritz, Julie M.; Thackeray, Anne] Univ Utah, Dept Phys Therapy, Salt Lake City, UT USA. [Fritz, Julie M.] Intermt Healthcare, Salt Lake City, UT USA. [Koppenhaver, Shane L.] US Army Baylor Univ Doctoral Program Phys Therapy, San Antonio, TX USA. [Teyhen, Deydre] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA. RP Hebert, JJ (reprint author), Murdoch Univ, Sch Psychol & Exercise Sci, 90 South St,ECL 4-008, Murdoch, WA 6150, Australia. EM J.Hebert@Murdoch.edu.au OI Thackeray, Anne/0000-0002-5496-7730; Hebert, Jeffrey/0000-0002-6959-325X FU Orthopaedic Section of the American Physical Therapy Association FX Orthopaedic Section of the American Physical Therapy Association. NR 50 TC 3 Z9 4 U1 1 U2 3 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0306-3674 EI 1473-0480 J9 BRIT J SPORT MED JI Br. J. Sports Med. PD JAN PY 2015 VL 49 IS 2 BP 100 EP U52 DI 10.1136/bjsports-2013-092402 PG 8 WC Sport Sciences SC Sport Sciences GA AX7OW UT WOS:000347105900008 PM 24029724 ER PT J AU Mudhasani, R Kota, KP Retterer, C Tran, JP Tritsch, SR Zamani, R Whitehouse, CA Bavari, S AF Mudhasani, Rajini Kota, Krishna P. Retterer, Cary Tran, Julie P. Tritsch, Sarah R. Zamani, Rouzbeh Whitehouse, Chris A. Bavari, Sina TI High-Content Image-Based Screening of a Signal Transduction Pathway Inhibitor Small-Molecule Library against Highly Pathogenic RNA Viruses SO JOURNAL OF BIOMOLECULAR SCREENING LA English DT Article DE antiviral drugs; high-content screening; cell-based assays; fluorescence methods ID RIFT-VALLEY FEVER; SPECTRUM ANTIVIRAL ACTIVITY; RIBAVIRIN; CHIKUNGUNYA; INTERFERON; INFECTION; PROTEIN; ASSAYS; ALPHA AB High-content image-based screening was developed as an approach to test a small-molecule library of compounds targeting signal transduction pathways for antiviral activity against multiple highly pathogenic RNA viruses. Of the 2843 compounds screened, 120 compounds exhibited 60% antiviral activity. Four compounds (E225-0969, E528-0039, G118-0778, and G544-0735), which were most active against Rift Valley fever virus (RVFV) and showed broad-spectrum antiviral activity, were selected for further evaluation for their concentration-response profile and cytotoxicity. These compounds did not show any visible cytotoxicity at the highest concentration of compound tested (200 mu M). All four of these compounds were more active than ribavirin against several viruses. One compound, E225-0969, had the lowest effective concentration (EC50 = 1.9-8.92 mu M) for all the viruses tested. This compound was 13- and 43-fold more inhibitory against RVFV and Chikungunya virus (CHIKV), respectively, than ribavirin. The highest selectivity index (>106.2) was for E225-0969 against CHIKV. Time-of-addition assays suggested that all four lead compounds targeted early steps in the viral life cycle (entry and/or replication) but not virus egress. Overall, this work demonstrates that high-content image analysis can be used to screen chemical libraries for new antivirals against highly pathogenic viruses. C1 [Mudhasani, Rajini; Kota, Krishna P.; Retterer, Cary; Tran, Julie P.; Tritsch, Sarah R.; Zamani, Rouzbeh; Whitehouse, Chris A.; Bavari, Sina] US Army Med Res Inst Infect Dis, Therapeut Discovery Ctr, Mol & Translat Sci Div, Frederick, MD 21702 USA. RP Bavari, S (reprint author), US Army Med Res Inst Infect Dis, Mol & Translat Sci Div, 1425 Porter St, Frederick, MD 21702 USA. EM sina.bavari.civ@mail.mil FU Defense Threat Reduction Agency (DTRA), Joint Science and Technology Office for Chem Bio Defense FX The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by funding from the Defense Threat Reduction Agency (DTRA), Joint Science and Technology Office for Chem Bio Defense (JSTO-CBM. THRV. 01.10. RD. 19), to S. B. Research by R. M. was supported in part by an appointment to the Faculty Research Participation Program at the U.S. Army Research and Materiel Command administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and the U.S. Army Medical Research and Material Command. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army or the U.S. government. NR 24 TC 4 Z9 4 U1 2 U2 5 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1087-0571 EI 1552-454X J9 J BIOMOL SCREEN JI J. Biomol. Screen PD JAN PY 2015 VL 20 IS 1 SI SI BP 141 EP 152 DI 10.1177/1087057114556253 PG 12 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Chemistry, Analytical SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Chemistry GA AX4RE UT WOS:000346918300016 PM 25342145 ER PT J AU Grujicic, M Ramaswami, S Snipes, JS Yavari, R Yen, CF Cheeseman, BA AF Grujicic, M. Ramaswami, S. Snipes, J. S. Yavari, R. Yen, C. -F. Cheeseman, B. A. TI Optimization of Gas Metal Arc Welding (GMAW) Process for Maximum Ballistic Limit in MIL A46100 Steel Welded All-Metal Armor SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE LA English DT Article DE ballistic limit; gas metal arc welding (GMAW) process optimization; MIL A46100 armor-grade steel ID MICROSTRUCTURE EVOLUTION; FAILURE MECHANISMS; HEAT-SOURCES; MODEL; PREDICTION; PHASES; AA5083 AB Our recently developed multi-physics computational model for the conventional gas metal arc welding (GMAW) joining process has been upgraded with respect to its predictive capabilities regarding the process optimization for the attainment of maximum ballistic limit within the weld. The original model consists of six modules, each dedicated to handling a specific aspect of the GMAW process, i.e., (a) electro-dynamics of the welding gun; (b) radiation-/convection-controlled heat transfer from the electric arc to the workpiece and mass transfer from the filler metal consumable electrode to the weld; (c) prediction of the temporal evolution and the spatial distribution of thermal and mechanical fields within the weld region during the GMAW joining process; (d) the resulting temporal evolution and spatial distribution of the material microstructure throughout the weld region; (e) spatial distribution of the as-welded material mechanical properties; and (f) spatial distribution of the material ballistic limit. In the present work, the model is upgraded through the introduction of the seventh module in recognition of the fact that identification of the optimum GMAW process parameters relative to the attainment of the maximum ballistic limit within the weld region entails the use of advanced optimization and statistical sensitivity analysis methods and tools. The upgraded GMAW process model is next applied to the case of butt welding of MIL A46100 (a prototypical high-hardness armor-grade martensitic steel) workpieces using filler metal electrodes made of the same material. The predictions of the upgraded GMAW process model pertaining to the spatial distribution of the material microstructure and ballistic limit-controlling mechanical properties within the MIL A46100 butt weld are found to be consistent with general expectations and prior observations. C1 [Grujicic, M.; Ramaswami, S.; Snipes, J. S.; Yavari, R.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. [Yen, C. -F.; Cheeseman, B. A.] Army Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM gmica@clemson.edu FU Army Research Office [W911NF-09-1-0513, W911NF-11-1-0207, W911NF-11-1-0518] FX The material presented in this paper is based on work supported by three Army Research Office sponsored grants entitled "Multi-length Scale Material Model Development for Armor-grade Composites" (Contract Number W911NF-09-1-0513), "Friction Stir Welding Behavior of Selected 2000-series and 5000-series Aluminum Alloys" (Contract Number W911NF-11-1-0207), and "Concept Validation and Optimization for a Vent-based Mine-blast Mitigation System" (Contract Number W911NF-11-1-0518). The authors are indebted to Dr. Ralph A. Anthenien, Jr. and Dr. Bryan J. Glaz of ARO for their continuing support and interest in the present work. NR 47 TC 7 Z9 7 U1 1 U2 10 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9495 EI 1544-1024 J9 J MATER ENG PERFORM JI J. Mater. Eng. Perform. PD JAN PY 2015 VL 24 IS 1 BP 229 EP 244 DI 10.1007/s11665-014-1274-3 PG 16 WC Materials Science, Multidisciplinary SC Materials Science GA AX6KG UT WOS:000347030600026 ER PT J AU Zubko, E Videen, G Shkuratov, Y AF Zubko, Evgenij Videen, Gorden Shkuratov, Yuriy TI Retrieval of dust-particle refractive index using the phenomenon of negative polarization SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article DE Negative polarization branch; Allende meteorite; Discrete dipole approximation; Irregularly shaped particles ID DISCRETE-DIPOLE APPROXIMATION; SCATTERING MATRICES; LIGHT-SCATTERING AB We study the phenomenon of negative polarization in irregularly shaped agglomerated debris particles. We find that the location of the negative polarization minimum is unambiguously governed by Re(m). Furthermore, the amplitude of the negative polarization puts a strong constraint on the material absorption in target particles regardless of their real part of refractive index Re(m). The interrelation can be parameterized with a simple formula and it can be utilized in remote sensing. We apply our finding to laboratory optical measurements of Allende meteorite at lambda=0.633 mu m and estimate its complex refractive index to be m approximate to (1.68-1.83)+(0.01-0.02)i. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Zubko, Evgenij; Shkuratov, Yuriy] Kharkov Natl Univ, Inst Astron, UA-61022 Kharkov, Ukraine. [Videen, Gorden] US Army Res Lab, RDRL CIE S, Adelphi, MD 20783 USA. [Videen, Gorden] Space Sci Inst, Boulder, CO 80301 USA. RP Zubko, E (reprint author), Kharkov Natl Univ, Inst Astron, 35 Sumskaya St, UA-61022 Kharkov, Ukraine. EM evgenij.s.zubko@gmail.com OI Zubko, Evgenij/0000-0001-9994-923X FU NASA Lunar Advanced Science and Exploration Research Program [NNX11AB25G]; NASA Outer Planets Research Program [NNX10AP93G] FX This work was partially supported by NASA Lunar Advanced Science and Exploration Research Program (Contract NNX11AB25G) and NASA Outer Planets Research Program (Contract NNX10AP93G). We thank anonymous referee for the constructive review. NR 22 TC 2 Z9 2 U1 1 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 EI 1879-1352 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD JAN PY 2015 VL 151 BP 38 EP 42 DI 10.1016/j.jqsrt.2014.09.015 PG 5 WC Optics; Spectroscopy SC Optics; Spectroscopy GA AY0BM UT WOS:000347263000006 ER PT J AU Wang, GX Pandey, R Karna, SP AF Wang, Gaoxue Pandey, Ravindra Karna, Shashi P. TI Phosphorene oxide: stability and electronic properties of a novel two-dimensional material SO NANOSCALE LA English DT Article ID REDUCED GRAPHENE OXIDE; FIELD-EFFECT TRANSISTORS; TRANSPORT-PROPERTIES; MONOLAYER; FILMS AB Phosphorene, the monolayer form of (black) phosphorus, was recently exfoliated from its bulk counterpart. Phosphorene oxide, by analogy to graphene oxide, is expected to have novel chemical and electronic properties, and may provide an alternative route to the synthesis of phosphorene. In this research, the physical and chemical properties of phosphorene oxide including its formation by oxygen adsorption on the bare phosphorene was investigated. Analysis of the phonon dispersion curves finds stoichiometric and non-stoichiometric oxide configurations to be stable at ambient conditions, thus suggesting that the oxygen adsorption may not degrade the phosphorene. The nature of the band gap of the oxides depends on the degree of functionalization of phosphorene; an indirect gap is predicted for the non-stoichiometric configurations, whereas a direct gap is predicted for the stoichiometric oxide. Application of mechanical strain or an external electric field leads to tunability of the band gap of the phosphorene oxide. In contrast to the case of the bare phosphorene, dependence of the diode-like asymmetric current-voltage response on the degree of stoichiometry is predicted for the phosphorene oxide. C1 [Wang, Gaoxue; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. [Karna, Shashi P.] US Army, Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA. RP Pandey, R (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. EM gaoxuew@mtu.edu; pandey@mtu.edu; shashi.p.karna.civ@mail.mil RI Wang, Gaoxue/C-9492-2017 OI Wang, Gaoxue/0000-0003-2539-3405 FU ARL [W911NF-14-2-0088] FX The authors thank D.R. Banyai for providing his STM simulation code, and are grateful to Dr S. Gowtham for his support with the installation of the required software. RAMA and Superior high performance computing clusters at the Michigan Technological University were used in obtaining the results presented in this paper. Financial support from ARL W911NF-14-2-0088 is acknowledged. NR 44 TC 44 Z9 46 U1 21 U2 232 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2040-3364 EI 2040-3372 J9 NANOSCALE JI Nanoscale PY 2015 VL 7 IS 2 BP 524 EP 531 DI 10.1039/c4nr05384b PG 8 WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA AX9TS UT WOS:000347245500020 PM 25412501 ER PT J AU Nair, HS Yadav, R Adiga, S Rao, SS van Tol, J Elizabeth, S AF Nair, Harikrishnan S. Yadav, Ruchika Adiga, Shilpa Rao, S. S. van Tol, Johan Elizabeth, Suja TI Ferrimagnetism and magnetic phase separation in Nd1-xYxMnO3 studied by magnetization and high frequency electron paramagnetic resonance SO PHYSICA B-CONDENSED MATTER LA English DT Article DE Ferrimagnetism; Magnetic phase separation; Manganites ID NDMNO3; POLARIZATION; DIFFRACTION; MN AB Ferrimagnetism and metamagnetic features tunable by composition are observed in the magnetic response of Nd1-xYxMnO3, for x=0.1-0.5. For all values of x in the series, the compound crystallizes in orthorhombic Pbnm space group similar to NdMnO3. Magnetization studies reveal a phase transition of the Mn-sublattice below T-N(Mn) approximate to 80 K for all compositions, which, decreases up on diluting the Nd-site with Yttrium. For x=0.35, ferrimagnetism is observed. At 5 K, metamagnetic transition is observed for all compositions x < 0.4. The evolution of magnetic ground states and appearance of ferrimagnetism in Nd1-xYxMnO3 can be accounted for by invoking the scenario of magnetic phase separation. The high frequency electron paramagnetic resonance measurements on x=0.4 sample, which is close to the critical composition for phase separation, revealed complex temperature dependent lineshapes clearly supporting the assumption of magnetic phase separation. (C) 2014 Elsevier B.V. All rights reserved. C1 [Nair, Harikrishnan S.; Yadav, Ruchika; Elizabeth, Suja] Indian Inst Sci, Dept Phys, Bangalore 560012, Karnataka, India. [Adiga, Shilpa] Forschungszentrum Julich, Peter Grunberg Inst 4, Julich Ctr Neutron Sci 2, D-52425 Julich, Germany. [Rao, S. S.] Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. [Rao, S. S.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [van Tol, Johan] Florida State Univ, Natl High Magnet Field Lab, Ctr Interdisciplinary Magnet Resonance, Tallahassee, FL 32310 USA. RP Nair, HS (reprint author), Indian Inst Sci, Dept Phys, Bangalore 560012, Karnataka, India. EM krishnair1@gmail.com FU Department of Science and Technology, India; national academy of sciences (NAS), USA FX S.E. wish to thank Department of Science and Technology, India for financial support. S.S.R. acknowledges national academy of sciences (NAS), USA for awarding national research council (NRC) postdoctoral research associate fellowship. NR 29 TC 0 Z9 0 U1 2 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0921-4526 EI 1873-2135 J9 PHYSICA B JI Physica B PD JAN 1 PY 2015 VL 456 BP 108 EP 114 DI 10.1016/j.physb.2014.08.044 PG 7 WC Physics, Condensed Matter SC Physics GA AX3LP UT WOS:000346841200020 ER PT J AU Sions, JM Velasco, TO Teyhen, DS Hicks, GE AF Sions, J. Megan Velasco, Teonette O. Teyhen, Deydre S. Hicks, Gregory E. TI Reliability of Ultrasound Imaging for the Assessment of Lumbar Multifidi Thickness in Older Adults With Chronic Low Back Pain SO JOURNAL OF GERIATRIC PHYSICAL THERAPY LA English DT Article DE chronic low back pain; multifidus; ultrasound imaging ID TRUNK MUSCLE COMPOSITION; CROSS-SECTIONAL AREA; BODY-COMPOSITION; INTERRATER RELIABILITY; FUNCTIONAL-CAPACITY; HEALTHY-INDIVIDUALS; EXTENSION ENDURANCE; ERECTOR SPINAE; LEG PAIN; STRENGTH AB Background and Purpose: Ultrasound imaging (USI) has been shown to be a reliable measure for direct assessment of the lumbar multifidi among younger adults. However, given age- and chronic low back pain (CLBP)-related spinal changes, similar studies are needed before clinical use of USI among older adults with CLBP. The goals of this study were to evaluate intra-and interexaminer reliability for USI assessment of multifidi thickness at rest and during a contraction and to determine standard error of measurement values (SEMs) and minimal detectable change values (MDCs) among older adults with CLBP. Methods: Thirty-one adults, aged 60 to 85 years, with CLBP were recruited. Two examiners performed USI assessments of multifidus thickness at rest and during a contralateral lower extremity lift. Intraclass correlation coefficients (ICCs) were used to estimate inter-and intraexaminer reliability. Additionally, SEMs and MDCs were calculated. Results: All USI measurement techniques demonstrated excellent within-day, interexaminer procedural reliability (ICCs: 0.82-0.85) and good-to-excellent between-day, interexaminer procedural reliability (ICCs: 0.72-0.79). The SEMs ranged from 0.36 to 0.46 cm; MDCs ranged from 1.01 to 1.26 cm. Regardless of the measurement technique, examiner 1, the more experienced examiner, demonstrated lower SEMs and MDCs than examiner 2. Discussion: Lower ICCs, greater SEMs, and greater MDCs for USI multifidus thickness assessment in older adults with CLBP, when compared with previously published, procedural reliability results for younger adults with and without low back pain, may indicate that imaging is more challenging in this patient population. Factors, such as examiner training and participant anthropometrics, may impact reliability. Conclusions: Good-to-excellent intra-and interexaminer USI procedural reliability may provide clinicians a direct assessment technique for clinical evaluation of the lumbar multifidi in older adults with CLBP. SEMs and MDCs may allow for accurate interpretation of USI assessments in this population. C1 [Sions, J. Megan; Velasco, Teonette O.; Hicks, Gregory E.] Univ Delaware, Dept Phys Therapy, Newark, DE 19713 USA. [Teyhen, Deydre S.] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA. RP Sions, JM (reprint author), Univ Delaware, 540 South Coll Ave,Suite 144A, Newark, DE 19713 USA. EM megsions@udel.edu FU Foundation for Physical Therapy PODS I/II; University of Delaware's Office of Graduate Studies [R21HD057274]; NIA [R01AG041202-01]; NICHD [R21 HD057274] FX The work of Dr. Sions is supported in part by the Foundation for Physical Therapy PODS I/II, the University of Delaware's Office of Graduate Studies, R21HD057274 (NICHD), and R01AG041202-01 (NIA). The work of Teonette Velasco and Dr. Hicks is supported in part by R21 HD057274 (NICHD) and R01AG041202-01 (NIA). NR 47 TC 0 Z9 0 U1 2 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1539-8412 EI 2152-0895 J9 J GERIATR PHYS THER JI J. Geriatr. Phys. Ther. PD JAN-MAR PY 2015 VL 38 IS 1 BP 33 EP 39 DI 10.1519/JPT.0000000000000021 PG 7 WC Geriatrics & Gerontology; Rehabilitation SC Geriatrics & Gerontology; Rehabilitation GA AX2HA UT WOS:000346762900004 PM 24743751 ER PT J AU Hire, JM Jacobs, JM Bundy, JV DeVine, JG AF Hire, Justin M. Jacobs, Jeremy M. Bundy, Justin V. DeVine, John G. TI A modified Bohlman technique using a novel implant for treatment of high-grade spondylolisthesis SO JOURNAL OF NEUROSURGERY-SPINE LA English DT Article DE modified Bohlman technique; AxiaLif TranS1 system; spondylolisthesis; spinal instrumentation; lumbar ID ISTHMIC SPONDYLOLISTHESIS; IN-SITU; REDUCTION; FUSION; INSTRUMENTATION; SPONDYLOLYSIS; DECOMPRESSION; ADOLESCENTS; CHILDREN AB Several surgical options for managing high-grade spondylolisthesis have been described in the literature and range from posterior-only in situ fusion to circumferential fusion with complete reduction of the dislocation. The level of evidence supporting any one technique is weak, and to date there is no Level I or II evidence supporting any current surgical treatment option. Techniques have evolved as implant technology has advanced and surgeons have gained experience with deformity correction. Still, the paucity of cases at any one institution limits the ability to perform clinical studies in a prospective and randomized fashion. To the authors' knowledge, the use of the AxiaLif bolt in a modified Bohlman technique has not been described. In the setting of a case of symptomatic high-grade spondylolisthesis refractory to nonoperative management, the authors describe a modified Bohlman technique in which they used the AxiaLif bolt rather than the fibula graft that was originally described. They then supplemented this with pedicle screw instrumentation and an iliac crest autograft. At the 2-year follow-up exam, the patient exhibited relief of his preoperative back and leg pain and he had returned to all activities. The latest radiographs demonstrated successful fusion. A single-stage, posterior instrumented fusion in which the AxiaLif bolt is used in lieu of fibula autograft or allograft in a modified,Bohlman technique is technically less demanding, does not have the morbidity associated with harvesting a fibula autograft, and carries no risk of disease transmission associated with the use of allograft. C1 [Hire, Justin M.; Jacobs, Jeremy M.; DeVine, John G.] Dwight D Eisenhower Army Med Ctr, Dept Orthopaed & Rehabil, Ft Gordon, GA 30905 USA. [Bundy, Justin V.] Doctors Hosp, Augusta, GA USA. RP Bundy, JV (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Orthopaed & Rehabil, 300 Hosp Rd, Ft Gordon, GA 30905 USA. EM justin.m.hire.mil@mail.mil NR 16 TC 1 Z9 1 U1 1 U2 3 PU AMER ASSOC NEUROLOGICAL SURGEONS PI ROLLING MEADOWS PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA SN 1547-5654 EI 1547-5646 J9 J NEUROSURG-SPINE JI J. Neurosurg.-Spine PD JAN PY 2015 VL 22 IS 1 BP 80 EP 83 DI 10.3171/2014.10.SPINE14138 PG 4 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA AX3CA UT WOS:000346817000013 PM 25380540 ER PT J AU Long, KN Houston, R Watson, JDB Morrison, JJ Rasmussen, TE Propper, BW Arthurs, ZM AF Long, Kira N. Houston, Robert Watson, J. Devin B. Morrison, Jonathan J. Rasmussen, Todd E. Propper, Brandon W. Arthurs, Zachary M. TI Functional Outcome after Resuscitative Endovascular Balloon Occlusion of the Aorta of the Proximal and Distal Thoracic Aorta in a Swine Model of Controlled Hemorrhage SO ANNALS OF VASCULAR SURGERY LA English DT Article ID NONCOMPRESSIBLE TORSO HEMORRHAGE; THORACOTOMY; SHOCK; STRATEGIES; INJURY; DEATH AB Background: Noncompressible torso hemorrhage remains an ongoing problem for both military and civilian trauma. Resuscitative endovascular balloon occlusion of the aorta (REBOA) has been characterized as a potentially life-saving maneuver. The objective of this study was to determine the functional outcomes, paraplegia rates, and survival of 60-min balloon occlusion in the proximal and distal thoracic aorta in a porcine model of controlled hemorrhage. Methods: Swine (Sus scrofa, 70-110 kg) were subjected to class IV hemorrhagic shock and underwent 60 min of REBOA. Devices were introduced from the left carotid artery and positioned in the thoracic aorta in either the proximal location (pREBOA [n = 8]; just past takeoff of left subclavian artery) or distal location (dREBOA [n = 8]; just above diaphragm). After REBOA, animals were resuscitated with whole blood, crystalloid, and vasopressors before a 4-day postoperative period. End points included evidence of spinal cord ischemia (clinical examination, Tarlov gait score, bowel and bladder dysfunction, and histopathology), gross ischemia-reperfusion injury (clinical examination and histopathology), and mortality. Results: The overall mortality was similar between pREBOA and dREBOA groups at 37.5% (n = 3). Spinal corderelated mortality was 12.5% for both pREBOA and dREBOA groups. Spinal cord symptoms without death were present in 12.5% of pREBOA and dREBOA groups. Average gait scores improved throughout the postoperative period. Conclusions: REBOA placement in the proximal or distal thoracic aorta does not alter mortality or paraplegia rates as compared with controlled hemorrhage alone. Functional recovery improves in the presence or the absence of REBOA, although at a slower rate after REBOA as compared with negative controls. Additional research is required to determine the ideal placement of REBOA in an uncontrolled hemorrhage model to achieve use compatible with survival outcomes and quality of life. C1 [Long, Kira N.; Rasmussen, Todd E.] 59th Med Wing, San Antonio, TX USA. [Long, Kira N.] Geneva Fdn, Tacoma, WA USA. [Long, Kira N.] Tulane Univ, Dept Surg, New Orleans, LA 70118 USA. [Houston, Robert; Watson, J. Devin B.; Propper, Brandon W.; Arthurs, Zachary M.] San Antonio Mil Med Ctr, Div Vasc Surg, San Antonio, TX USA. [Morrison, Jonathan J.] Royal Ctr Def Med, Birmingham, W Midlands, England. [Rasmussen, Todd E.] US Army Inst Surg Res, San Antonio, TX USA. RP Long, KN (reprint author), Tulane Univ, Dept Surg, 1430 Tulane Ave,SL-22, New Orleans, LA 70112 USA. EM klong2@tulane.edu OI Morrison, Jonathan/0000-0001-7462-8456 NR 16 TC 7 Z9 7 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0890-5096 EI 1615-5947 J9 ANN VASC SURG JI Ann. Vasc. Surg. PD JAN PY 2015 VL 29 IS 1 BP 114 EP 121 DI 10.1016/j.avsg.2014.10.004 PG 8 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA AW4GS UT WOS:000346239900018 PM 25449984 ER PT J AU Stynoski, P Mondal, P Marsh, C AF Stynoski, Peter Mondal, Paramita Marsh, Charles TI Effects of silica additives on fracture properties of carbon nanotube and carbon fiber reinforced Portland cement mortar SO CEMENT & CONCRETE COMPOSITES LA English DT Article DE Portland cement; Fracture toughness; Carbon nanotube; Carbon fiber; Silica fume; Interfacial transition zone ID COMPOSITE PVA-ECC; MECHANICAL-PROPERTIES; CONCRETE; MICROSTRUCTURE; DISPERSION; INTERFACE; BEHAVIOR; MATRIX AB Fiber reinforcements provide many benefits to cementitious composites, including reduction of crack widths and increases in ductility. However, the interfacial transition zone between fibers and hydrated cement can contain a high proportion of calcium hydroxide and porosity. With their high moduli of elasticity, carbon nanotubes and carbon fibers could provide substantial mechanical reinforcement at multiple length scales, but only if their bond to the matrix can be controlled. Surface treatments of fibers and addition of supplemental materials in the matrix can influence both the mechanical interaction at the interface and the dispersion of these relatively small reinforcements. We performed a broad study of Portland cement mortar mixtures containing silica fume, plain or silica-functionalized carbon nanotubes, and carbon fibers to characterize changes in fracture properties. The early age hydration kinetics of cement pastes containing carbon nanotubes were compared using isothermal calorimetry. Early age fracture surfaces of cement pastes containing carbon fibers were observed using a scanning electron microscope. The notched beam test method of the Two Parameter Fracture Model was used to determine the fracture properties of each mix. We observed that silica fume and silica functional groups improved the fracture performance of mixtures containing carbon nanotubes and carbon fibers. Further optimization of dosage, size, and interface strength is required to fully utilize carbon nanotubes in cementitious composites. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Stynoski, Peter; Mondal, Paramita] Univ Illinois, Dept Civil & Environm Engn, Urbana, IL 61801 USA. [Stynoski, Peter; Marsh, Charles] US Army Construct Engn Res Lab, Champaign, IL 61822 USA. [Marsh, Charles] Univ Illinois, Dept Nucl Plasma & Radiol Engn, Urbana, IL 61801 USA. RP Stynoski, P (reprint author), Univ Illinois, Dept Civil & Environm Engn, 205 N Mathews Ave, Urbana, IL 61801 USA. EM pstynos2@illinois.edu; pmondal@illinois.edu; charles.p.marsh@usace.army.mil FU US Army Corps of Engineers Engineer Research and Development Center (ERDC) FX The authors gratefully acknowledge the assistance of Mr. Erik Wotring, University of Illinois at Urbana-Champaign, in the laboratory. We also appreciate the valuable input of Prof. Amanda Bordelon, University of Utah, and Dr. David Farrow, University of Illinois at Urbana-Champaign, while configuring the load frame and test protocol. This research is supported in part by the Section 219 authority of the US Army Corps of Engineers Engineer Research and Development Center (ERDC) under the projects, "Effects of Grain Boundaries on Ceramic Properties," and, "Advancing the Development of the Super Ceramic and Associated Technologies." NR 33 TC 8 Z9 8 U1 7 U2 45 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0958-9465 EI 1873-393X J9 CEMENT CONCRETE COMP JI Cem. Concr. Compos. PD JAN PY 2015 VL 55 BP 232 EP 240 DI 10.1016/j.cemconcomp.2014.08.005 PG 9 WC Construction & Building Technology; Materials Science, Composites SC Construction & Building Technology; Materials Science GA AW4AS UT WOS:000346224600026 ER PT J AU O'Brien, DJ Baechle, DM Yurchak, OB Wetzel, ED AF O'Brien, D. J. Baechle, D. M. Yurchak, O. B. Wetzel, E. D. TI Effect of processing conditions and electrode characteristics on the electrical properties of structural composite capacitors SO COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING LA English DT Article DE Smart materials; Hybrid; Electrical properties; Cure ID ENERGY-STORAGE; DIELECTRIC-BREAKDOWN; FILM CAPACITOR; CARBON-FIBERS; PERFORMANCE; POLYMERS; VOLTAGE; DESIGN; FIELD AB Structural capacitors are manufactured from glass fabric/epoxy prepreg dielectrics and metalized polymer film electrodes. The electrical breakdown strengths of these multifunctional materials are investigated across a wide range of electrode constructions and processing parameters. The results show that electrode selection and materials processing have a significant impact on the energy that the device can store. Also, this careful consideration of processing parameters and electrode construction has led to the development of a structural capacitor with an energy density exceeding 0.90 J/cm(3), the highest yet reported. Published by Elsevier Ltd. C1 [O'Brien, D. J.; Baechle, D. M.; Yurchak, O. B.; Wetzel, E. D.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP O'Brien, DJ (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM daniel.j.obrien58.civ@mail.mil NR 42 TC 2 Z9 2 U1 3 U2 27 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-835X EI 1878-5840 J9 COMPOS PART A-APPL S JI Compos. Pt. A-Appl. Sci. Manuf. PD JAN PY 2015 VL 68 BP 47 EP 55 DI 10.1016/j.compositesa.2014.09.003 PG 9 WC Engineering, Manufacturing; Materials Science, Composites SC Engineering; Materials Science GA AW7OE UT WOS:000346452400006 ER PT J AU Keawcharoen, J Techangamsuwan, S Ponpornpisit, A Lombardini, ED Patchimasiri, T Pirarat, N AF Keawcharoen, J. Techangamsuwan, S. Ponpornpisit, A. Lombardini, E. D. Patchimasiri, T. Pirarat, N. TI Genetic characterization of a betanodavirus isolated from a clinical disease outbreak in farm-raised tilapia Oreochromis niloticus (L.) in Thailand SO JOURNAL OF FISH DISEASES LA English DT Article DE betanodavirus; farm-raised tilapia; Genetic characteristic; Thailand ID NERVOUS-NECROSIS-VIRUS; HALIBUT HIPPOGLOSSUS-HIPPOGLOSSUS; GROUPER EPINEPHELUS-AKAARA; FRESH-WATER; NODAVIRUS INFECTION; COAT PROTEIN; FISH NODAVIRUS; CAPSID PROTEIN; MARINE FISH; ENCEPHALOPATHY AB Betanodavirus infection was diagnosed in larvae of farm-raised tilapia Oreochromisniloticus (L.), in central Thailand. Extensive vacuolar degeneration and neuronal necrosis were observed in histological sections with positive immunohistochemical staining for betanodavirus. Molecular phylogenetic analysis was performed based on the nucleotide sequences (1333 bases) of the capsid protein gene. The virus strain was highly homologous (93.07-93.88%) and closely related to red-spotted grouper nervous necrosis virus (RGNNV). C1 [Keawcharoen, J.] Chulalongkorn Univ, Dept Vet Microbiol, Fac Vet Sci, Bangkok 10330, Thailand. [Techangamsuwan, S.; Pirarat, N.] Chulalongkorn Univ, Dept Pathol, Fac Vet Sci, Bangkok 10330, Thailand. [Ponpornpisit, A.] Chulalongkorn Univ, Dept Vet Med, Fac Vet Sci, Bangkok 10330, Thailand. [Lombardini, E. D.] Armed Forces Res Inst Med Sci, Div Comparat Pathol, Dept Vet Med, Bangkok, Thailand. [Lombardini, E. D.] Armed Forces Res Inst Med Sci, Div Res, Dept Vet Med, Bangkok, Thailand. [Patchimasiri, T.] Natl Inst Anim Hlth, Pathol Sect, Bangkok, Thailand. RP Pirarat, N (reprint author), Chulalongkorn Univ, Dept Pathol, Fac Vet Sci, Bangkok 10330, Thailand. EM piraratnop@hotmail.com NR 32 TC 4 Z9 6 U1 2 U2 14 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0140-7775 EI 1365-2761 J9 J FISH DIS JI J. Fish Dis. PD JAN PY 2015 VL 38 IS 1 BP 49 EP 54 DI 10.1111/jfd.12200 PG 6 WC Fisheries; Marine & Freshwater Biology; Veterinary Sciences SC Fisheries; Marine & Freshwater Biology; Veterinary Sciences GA AW9MC UT WOS:000346580400006 PM 24164433 ER PT J AU Levy, J Ernat, J Song, D Cook, JB Judd, D Shaha, S AF Levy, Jeffrey Ernat, Justin Song, Daniel Cook, Jay B. Judd, Daniel Shaha, Steven TI Outcomes of Long-arm Casting Versus Double-Sugar-Tong Splinting of Acute Pediatric Distal Forearm Fractures SO JOURNAL OF PEDIATRIC ORTHOPAEDICS LA English DT Article DE Level II-prospective; comparative study ID EPIPHYSEAL PLATES; RADIAL FRACTURES; PLASTER CASTS; RISK-FACTORS; CHILDREN; REDISPLACEMENT; ORIENTATION; 3RD AB Introduction: The traditional treatment after closed reduction of distal radius (DR) and distal both bone (DBB) forearm fractures has been application of a long-arm cast (LAC) or a short-arm cast (SAC). Splinting is another option that avoids the potential complications associated with casting. The purpose of this study is to evaluate the maintenance of reduction of DR or DBB fractures placed in a double-sugar-tong splint (DSTS) compared with a LAC in a pediatric population. Methods: This is an IRB-approved, prospective, randomized trial. Patients aged 4 to 12 years with DR or DBB fractures treated at a single institution between 2010 and 2012 were enrolled. After reduction, fractures were placed into either a LAC or a DSTS. Radiographs were reviewed at initial injury, postreduction, and at set intervals for angulation, displacement, and apposition, as well as cast index and 3-point index. The DSTS was overwrapped into a cast after week 1. The immobilization device was changed to a SAC at week 4 or 6. Total duration of immobilization was 6 to 8 weeks. Results: Seventy-one patients were enrolled with 37 in the LAC and 34 in the DSTS. Average age was 8.73 years (range, 4 to 12) with 43 being males. There were 28 isolated DR and 43 DBB fractures. There were no week-to-week differences between the 2 groups in regards to sagittal alignment, coronal alignment, apposition, or displacement. Sagittal alignment at immediate postreduction and week 2 showed that the DSTS was slightly better (average 2.0 vs. 5.0 degrees, respectively, P = 0.04). For the entire treatment period there was an increased risk of loss of reduction of >= 10 degrees in the LAC group versus the DSTS group (7 patients vs. 2 patients, respectively, P = 0.0001), and of meeting the criteria for remanipulation (10 patients vs. 5 patients, respectively, P = 0.01). At cast removal, there was no difference between groups. Conclusions: Although there were significant differences between the 2 groups with regards to risk of reduction loss, the DSTS and LAC were comparable in maintenance of reduction at the time of cast removal. Both the DSTS and LAC are appropriate immobilization devices for these pediatric fractures. Level of Evidence: Level II-prospective, comparative study. C1 [Levy, Jeffrey; Ernat, Justin; Song, Daniel; Cook, Jay B.] Tripler Army Med Ctr, Dept Orthopaed Surg, Honolulu, HI 96859 USA. [Judd, Daniel] St Lukes, Sun Valley Sports Med, Hailey, ID USA. [Shaha, Steven] Univ Utah, Draper, UT USA. RP Ernat, J (reprint author), Tripler Army Med Ctr, Dept Orthopaed Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM justin.ernat@gmail.com NR 20 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0271-6798 EI 1539-2570 J9 J PEDIATR ORTHOPED JI J. Pediatr. Orthop. PD JAN PY 2015 VL 35 IS 1 BP 11 EP 17 PG 7 WC Orthopedics; Pediatrics SC Orthopedics; Pediatrics GA AW3MC UT WOS:000346189800004 PM 24787302 ER PT J AU Percival, TJ Patel, S Markov, NP Morrison, JJ Spencer, JR Ross, JD Rasmussen, TE AF Percival, Thomas J. Patel, Shimul Markov, Nickolay P. Morrison, Jonathan J. Spencer, Jerry R. Ross, James D. Rasmussen, Todd E. TI Prophylactic fasciotomy in a porcine model of extremity trauma SO JOURNAL OF SURGICAL RESEARCH LA English DT Article DE Vascular injury; Extremity; Ischemia reperfusion; Recovery; Neuromuscular; Functional; Fasciotomy ID VASCULAR INJURY; COMPARTMENT SYNDROME; OUTCOME ANALYSIS; COMPLICATIONS; REPERFUSION; MANAGEMENT; ISCHEMIA AB Background: Extremity injury, with concomitant hemorrhagic shock, can result in ischemia-reperfusion injury and the formation of compartment syndrome requiring fasciotomy. As the benefit of prophylactic fasciotomy is unclear, the objective of this study is to determine the functional recovery of an ischemic limb with hemorrhagic shock after prophylactic fasciotomy. Material and methods: Yorkshire swine underwent 35% blood volume hemorrhage, followed by 1, 3, and 6 h of ischemia (n = 17; 1HR, 3HR, and 6HR) via iliac artery occlusion followed by repair and reperfusion. A second cohort (n = 18) underwent fasciotomy of the anterior compartment of the hind limb following vascular repair (1HR-F, 3HR-F, and 6HR-F). Compartment pressures, measures of electromyographic (EMG) recovery, and a validated gait score (modified Tarlov) were performed throughout a 14-d survival period. Results: Increasing ischemic intervals resulted in incremental increases in compartment pressure (P < 0.05), although the mean did not exceed 30 mm Hg. EMG studies did not show a significant improvement comparing the 3HR with 6HR groups. There was a significant improvement in the EMG studies within the 3HR-F, when compared with 6HR-F. There was a trend toward sensory improvement between the 3HR-F and 3HR groups. However, this did not translate to a difference in functional outcome as measured by the Tarlov gait score. Conclusions: Within this swine model of hemorrhagic shock and hind limb ischemia, the use of prophylactic fasciotomies did not improve functional outcome. Published by Elsevier Inc. C1 [Percival, Thomas J.; Markov, Nickolay P.; Spencer, Jerry R.; Ross, James D.; Rasmussen, Todd E.] Joint Base San Antonio, Med Wing 59, San Antonio, TX USA. [Percival, Thomas J.; Patel, Shimul; Markov, Nickolay P.; Morrison, Jonathan J.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Morrison, Jonathan J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. [Morrison, Jonathan J.] Glasgow Royal Infirm, Acad Surg Unit, Glasgow G4 0SF, Lanark, Scotland. [Rasmussen, Todd E.] US Combat Casualty Care Res Program, Ft Detrick, MD 21702 USA. [Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Bethesda, MD USA. RP Rasmussen, TE (reprint author), US Combat Casualty Care Res Program, 722 Doughten St,Room 3, Ft Detrick, MD 21702 USA. EM todd.e.rasmussen.mil@mail.mil OI Morrison, Jonathan/0000-0001-7462-8456 FU United States Air Force FX Authors' contributions: T.E.R. and T.J.P. jointly conceived the study and obtained funding from the United States Air Force. T.J.P., S.P., N.P.M., and J.R.S. executed the experiments. J.R.S. managed the material and personnel needs within the laboratory and managed the financial aspects of the protocol. T.E.R., T.J.P., J.J.M., and J.R.S. analyzed and interpreted the data and wrote the article. J.J.M. and T.J.P. revised the article. J.J.M. administered the submission process. NR 20 TC 0 Z9 0 U1 0 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-4804 EI 1095-8673 J9 J SURG RES JI J. Surg. Res. PD JAN PY 2015 VL 193 IS 1 BP 449 EP 457 DI 10.1016/j.jss.2014.07.016 PG 9 WC Surgery SC Surgery GA AW4HH UT WOS:000346241300058 PM 25124897 ER PT J AU Bianchini, A Gonzalez, CR Barker, WR AF Bianchini, Alessandra Gonzalez, Carlos R. Barker, Walter R. TI Recommendations for the Minimum Thickness of Concrete Pavements Supporting F-15 and C-17 Aircrafts SO JOURNAL OF TRANSPORTATION ENGINEERING LA English DT Article DE Rigid pavements; Minimum thickness; Strain gauges; Full-scale pavement test section; Heavy aircraft pavement AB The procedure for the design of military rigid airfield pavements contained in the Unified Facilities Criteria 3-260-02 gives the minimum thickness of airfield concrete pavements as 152mm (6in.). The introduction of the C-17 aircraft and the requirement of dowel bars as a joint load transfer mechanism bring into question the validity of the 152-mm (6-in.) minimum thickness. With the objective of updating such minimum thickness criteria, a full-scale test section was constructed and trafficked with loads simulating F-15, B-52, and C-17 aircraft landing gear. Evaluation of the test section performance and analysis of the strain data supported a U.S. Army Engineer Research and Development Center team recommendations that the minimum pavement thickness be increased to 203mm (8in.) for any doweled airfield pavement and that the minimum thickness of 279mm (11in.) should be required for those pavements supporting C-17 aircraft. C1 [Bianchini, Alessandra] Airbase Recovery & Acquisit SME, Tyndall AFB, FL 32403 USA. [Bianchini, Alessandra; Gonzalez, Carlos R.] US Army, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Bianchini, A (reprint author), Airbase Recovery & Acquisit SME, AFCEC CXAI 139 Barnes Dr,Ste 2, Tyndall AFB, FL 32403 USA. EM alessandra.bianchini@us.af.mil; carlos.r.gonzalez@usace.army.mil; wrbarker37@gmail.com NR 5 TC 0 Z9 0 U1 2 U2 9 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-947X EI 1943-5436 J9 J TRANSP ENG JI J. Transp. Eng. PD JAN PY 2015 VL 141 IS 1 AR 06014002 DI 10.1061/(ASCE)TE.1943-5436.0000732 PG 6 WC Engineering, Civil; Transportation Science & Technology SC Engineering; Transportation GA AW5WQ UT WOS:000346342200010 ER PT J AU Voiry, D Goswami, A Kappera, R Silva, CDCE Kaplan, D Fujita, T Chen, MW Asefa, T Chhowalla, M AF Voiry, Damien Goswami, Anandarup Kappera, Rajesh Castro e Silva, Cecilia de Carvalho Kaplan, Daniel Fujita, Takeshi Chen, Mingwei Asefa, Tewodros Chhowalla, Manish TI Covalent functionalization of monolayered transition metal dichalcogenides by phase engineering SO NATURE CHEMISTRY LA English DT Article ID SINGLE-LAYER MOS2; CHEMICALLY EXFOLIATED MOS2; WALLED CARBON NANOTUBES; HYDROGEN EVOLUTION; RESTACKED MOS2; NANOSHEETS; WS2; PHOTOLUMINESCENCE; INTERCALATION; CHEMISTRY AB Chemical functionalization of low-dimensional materials such as nanotubes, nanowires and graphene leads to profound changes in their properties and is essential for solubilizing them in common solvents. Covalent attachment of functional groups is generally achieved at defect sites, which facilitate electron transfer. Here, we describe a simple and general method for covalent functionalization of two-dimensional transition metal dichalcogenide nanosheets (MoS2, WS2 and MoSe2), which does not rely on defect engineering. The functionalization reaction is instead facilitated by electron transfer between the electron-rich metallic 1T phase and an organohalide reactant, resulting in functional groups that are covalently attached to the chalcogen atoms of the transition metal dichalcogenide. The attachment of functional groups leads to dramatic changes in the optoelectronic properties of the material. For example, we show that it renders the metallic 1T phase semiconducting, and gives it strong and tunable photoluminescence and gate modulation in field-effect transistors. C1 [Voiry, Damien; Kappera, Rajesh; Castro e Silva, Cecilia de Carvalho; Chhowalla, Manish] Rutgers State Univ, Piscataway, NJ 08854 USA. [Goswami, Anandarup; Asefa, Tewodros] Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 USA. [Goswami, Anandarup; Asefa, Tewodros] Rutgers State Univ, Dept Chem & Biochem Engn, Piscataway, NJ 08854 USA. [Kaplan, Daniel] US Army RDECOM ARDEC, Acoust & Networked Sensors Div, Picatinny Arsenal, NJ 07806 USA. [Fujita, Takeshi; Chen, Mingwei] Tohoku Univ, WPI Adv Inst Mat Res, Sendai, Miyagi 9808577, Japan. [Fujita, Takeshi] JST, PRESTO, Kawaguchi, Saitama 3320012, Japan. RP Chhowalla, M (reprint author), Rutgers State Univ, 607 Taylor Rd, Piscataway, NJ 08854 USA. EM manish1@rci.rutgers.edu RI Fujita, Takeshi/B-1867-2009; Chen, Mingwei/A-4855-2010; Voiry, Damien/G-3541-2016; OI Fujita, Takeshi/0000-0002-2318-0433; Chen, Mingwei/0000-0002-2850-8872; Voiry, Damien/0000-0002-1664-2839; Kappera, Rajesh/0000-0003-1792-4405 FU National Science Foundation Division of Graduate Education (NSF DGE) [0903661]; NSF [Chemistry-1004218, DMR-0968937, NanoEHS-1134289]; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-Brazil; Japan Science and Technology Agency-PRESTO; Japan Society for Promotion of Science [90363382] FX M. Chhowalla, D.V. and R.K. acknowledge financial support from the National Science Foundation Division of Graduate Education (NSF DGE) 0903661. T.A. and A.G. acknowledge financial assistance from the NSF (CAREER Chemistry-1004218, DMR-0968937, NanoEHS-1134289, NSF-Analytical Chemistry Instrumentation Facility and a Special Creativity Grant). C.S. acknowledges the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-Brazil, for a fellowship. T.F. acknowledges partial support from Japan Science and Technology Agency-PRESTO ('New Materials Science and Element Strategy') and Japan Society for Promotion of Science (Grant-in-Aid for Scientific Research on Innovative Areas 'Science of Atomic Layers', 90363382). The authors thank G.S. Hall for ATR-FTIR measurements. G. Recine at New York University Polytechnic is thanked for computing time. NR 32 TC 91 Z9 91 U1 60 U2 344 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1755-4330 EI 1755-4349 J9 NAT CHEM JI Nat. Chem. PD JAN PY 2015 VL 7 IS 1 BP 45 EP 49 DI 10.1038/NCHEM.2108 PG 5 WC Chemistry, Multidisciplinary SC Chemistry GA AW6XQ UT WOS:000346409400011 PM 25515889 ER PT J AU Blake, MB Saleh, I Wei, Y Schlesinger, ID Yale-Loehr, A Liu, XZ AF Blake, M. Brian Saleh, Iman Wei, Yi Schlesinger, Ian D. Yale-Loehr, Alexander Liu, Xuanzhe TI Shared service recommendations from requirement specifications: A hybrid syntactic and semantic toolkit SO INFORMATION AND SOFTWARE TECHNOLOGY LA English DT Article DE Requirements engineering; Similarity analysis; Shared service discovery ID WEB SERVICES AB Context: Software Requirement Specifications (SRSs) are central to software lifecycles. An SRS defines the functionalities and constraints of a desired software system, hence it often serves as reference for further development. Software lifecycles concerned with the conversion of traditional systems into more service-oriented infrastructures can benefit from understanding potential shared capabilities through the analysis of SRSs. Objective: In this paper, we propose an automated approach capable of recommending shared software services from multiple text-based SRSs created by different organizations. Our goal is to facilitate the identification of overlapping requirements in these specifications and subsequently recommend shared components, which promotes software reuse. The shared components can be implemented as services that are invoked across different systems. Method: Our approach leverages the syntactic similarity of the SRS text augmented with semantic information derived from the WordNet database. This work extends our earlier studies by introducing an algorithm that utilizes noun, verb, and predicate relations to enhance the discovery of equivalent requirements and the recommendation of reusable services. A prototype system is implemented to evaluate the approach and experimental results have shown effective recommendation of requirements and their realized shared services. Results: our automatic recommendation approach generates recommendations in few minutes compared to 9 h when services are manually inspected by developers. Our approach is also able to recommend services that are overlooked by the same developers, and to identify similarity between requirements even if these requirements are reworded. Conclusion: We show through experimentation that we can efficiently recommend services by leveraging both the syntactical structure and the semantic information of a requirements document and that our approach is more effective than the manual selection of services by experts. We also show that our approach is effective in detecting similar requirements for a single system and hence discovering opportunities for software reuse. (C) 2014 Elsevier B.V. All rights reserved. C1 [Blake, M. Brian; Saleh, Iman] Univ Miami, Coral Gables, FL 33124 USA. [Wei, Yi] Microsoft Corp, Seattle, WA USA. [Schlesinger, Ian D.] Georgetown Univ, Washington, DC USA. [Yale-Loehr, Alexander] US Army Corps Engn, Alexandria, VA USA. [Liu, Xuanzhe] Peking Univ, Beijing 100871, Peoples R China. RP Saleh, I (reprint author), Univ Miami, Coral Gables, FL 33124 USA. EM iman@miami.edu FU NSF [0940553, 1004014, 0705130] FX We would like to acknowledge the prior work and discussions with Mr. Michael F. Nowlan with regards to the TSM-L approach. We acknowledge discussions with Dr. Aubrey Rembert in the development of the recommendation modeling. This work was supported in part by NSF Award Nos. 0940553, 1004014, and 0705130. NR 33 TC 0 Z9 0 U1 3 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0950-5849 EI 1873-6025 J9 INFORM SOFTWARE TECH JI Inf. Softw. Technol. PD JAN PY 2015 VL 57 BP 392 EP 404 DI 10.1016/j.infsof.2014.05.019 PG 13 WC Computer Science, Information Systems; Computer Science, Software Engineering SC Computer Science GA AU9YI UT WOS:000345947500023 ER PT J AU Wilson, KL Allen, MS Ahrens, RNM Netherland, MD AF Wilson, Kyle L. Allen, Micheal S. Ahrens, Robert N. M. Netherland, Michael D. TI Use of underwater video to assess freshwater fish populations in dense submersed aquatic vegetation SO MARINE AND FRESHWATER RESEARCH LA English DT Article DE complex habitats; fish sampling; Hydrilla verticillata; invasive aquatic plants; largemouth bass; sunfish; video cameras ID COUNT DATA; BLUEGILL SUNFISH; CAMERA SYSTEM; ABUNDANCE; FLORIDA; LAKES; COMMUNITIES; MACROPHYTES; PATTERNS; BEHAVIOR AB Underwater video cameras (UVC) provide a non-lethal technique to sample fish in dense submersed aquatic vegetation. Fish often inhabit densely vegetated areas, but deficiencies of most sampling gears bias relative abundance estimates that inform fisheries management. This study developed methods using UVC to estimate relative abundance in dense vegetation using three experimental ponds covered with surface-matted hydrilla (Hydrilla verticillata) stocked at different densities of Lepomis spp. and largemouth bass (Micropterus salmoides). We conducted UVC point counts over 13 weeks to measure relative fish abundance and occurrence from video analysis. Ponds were then drained to obtain true fish densities. In total, fish were detected in 55% of all counts and juvenile and adult Lepomis spp. and largemouth bass were enumerated. End-of-season true fish densities ranged across ponds (from 52 to 37 000 fish ha(-1)). Additionally, pond 2's true density changed substantially from 370 to 12 300 fish ha(-1). True population size was accurately reflected in differences in estimated relative abundances obtained from fish counts, as in pond 2 where mean fish counts increased from 0.10 in week 1 to 2.33 by week 13. Underwater video accurately and precisely quantified relative abundance at naturally-occurring fish densities, but this success was reduced at low densities. C1 [Wilson, Kyle L.; Allen, Micheal S.; Ahrens, Robert N. M.] Univ Florida, Sch Forest Resources & Conservat, Fisheries & Aquat Sci Program, Gainesville, FL 32653 USA. [Netherland, Michael D.] US Army, Engn Res & Dev Ctr, Gainesville, FL 32653 USA. RP Wilson, KL (reprint author), Univ Calgary, Dept Biol Sci, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada. EM wilsok@ucalgary.ca OI Wilson, Kyle/0000-0002-0870-0509 FU Florida Fish and Wildlife Conservation Commission Invasive Plant Management Section FX The authors thank the Florida Fish and Wildlife Conservation Commission Invasive Plant Management Section for financial support and the United States Geological Survey South-eastern Ecological Science Center for logistics and access to the experimental ponds. They would also like to thank the University of Florida's Dan Gwinn, Ed Camp, and Jeremy Slade for advice during the development of this manuscript, as well as Erin Bradshaw, Nicholas Cole, Zack Slagle, Simone Nageon de Lestang, and Antonio Malouf for field collections and video analysis. We thank the Associate Editor, Russell Death, as well as Brendan Ebner and three anonymous reviewers for the feedback to improve the manuscript. NR 54 TC 1 Z9 1 U1 5 U2 44 PU CSIRO PUBLISHING PI COLLINGWOOD PA 150 OXFORD ST, PO BOX 1139, COLLINGWOOD, VICTORIA 3066, AUSTRALIA SN 1323-1650 EI 1448-6059 J9 MAR FRESHWATER RES JI Mar. Freshw. Res. PY 2015 VL 66 IS 1 BP 10 EP 22 DI 10.1071/MF13230 PG 13 WC Fisheries; Limnology; Marine & Freshwater Biology; Oceanography SC Fisheries; Marine & Freshwater Biology; Oceanography GA AW3KH UT WOS:000346184900002 ER PT J AU Guo, ZR Hong, J Zheng, J Chen, WN AF Guo, Zherui Hong, Jihye Zheng, James Chen, Weinong TI Out-of-plane effects on dynamic pull-out of p-phenylene terephthalamide yarns SO TEXTILE RESEARCH JOURNAL LA English DT Article DE yarn; pull-out; dynamic; out-of-plane; pendulum; impact ID BALLISTIC IMPACT ENERGY; SINGLE YARN; BEHAVIOR; PERFORMANCE; MECHANISM; FRICTION AB In this study, the mechanical response of a single yarn pull-out from single layers of Kevlar (R) and Twaron (R) fabric under out-of-plane loading at dynamic rates was experimentally investigated, as ballistic applications typically occur at higher velocities and out-of-plane directions compared to previous literature. In order to perform the dynamic experiments, a pendulum impact setup was designed and constructed to pull out a single yarn dynamically. The pull-out load was measured directly by a load cell and the movement of the fabric was measured to portray the load-displacement history. The effects of fabric length, out-of-plane versus in-plane yarn pull-out, and constraining boundary conditions were compared. C1 [Guo, Zherui; Chen, Weinong] Purdue Univ, Sch Aeronaut & Astronaut, W Lafayette, IN 47906 USA. [Hong, Jihye] Jatco Korea Engn Corp, Seoul, South Korea. [Zheng, James] US Army, Program Execut Off Soldier, Brooklyn, NY USA. [Chen, Weinong] Purdue Univ, Sch Mat Engn, W Lafayette, IN 47907 USA. RP Guo, ZR (reprint author), Purdue Univ, Sch Aeronaut & Astronaut, 2116 McCormick Rd, W Lafayette, IN 47906 USA. EM gzherui@purdue.edu NR 15 TC 0 Z9 0 U1 0 U2 4 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0040-5175 EI 1746-7748 J9 TEXT RES J JI Text. Res. J. PD JAN PY 2015 VL 85 IS 2 BP 140 EP 149 DI 10.1177/0040517514542865 PG 10 WC Materials Science, Textiles SC Materials Science GA AU6XK UT WOS:000345744600003 ER PT J AU Whipps, GT Ertin, E Moses, RL AF Whipps, Gene T. Ertin, Emre Moses, Randolph L. GP IEEE TI Distributed Sensing for Quickest Change Detection of Point Radiation Sources SO 2015 18TH INTERNATIONAL CONFERENCE ON INFORMATION FUSION (FUSION) LA English DT Proceedings Paper CT 18th International Conference on Information Fusion (Fusion) CY JUL 06-09, 2015 CL Washington, DC AB We consider the problem of distributed detection of a radioactive source using a network of emission count sensors. Sensor nodes observe their environment and a central fusion node attempts to detect a change in the joint probability distribution due to the appearance of a hazardous source at an unknown time and location. We consider a minimax-type distributed change-point detection problem that minimizes detection delay for a desired false alarm rate. A statistical model of the radiation source detection problem is formulated where sensors observations are correlated with non-identical distributions. We first derive a centralized detection algorithm that is asymptotically optimal for vanishing false alarm rate. Then we analyze the performance loss, as measured by the detection latency, when sensor counts are quantized at each sensor node. The detection latency of the centralized rule provides a lower bound on performance for the proposed distributed method. The empirical results indicate that the distributed detection strategy provides a reasonable tradeoff between latency and information bandwidth. C1 [Whipps, Gene T.; Ertin, Emre; Moses, Randolph L.] Ohio State Univ, ECE Dept, Columbus, OH 43210 USA. [Whipps, Gene T.] US Army Res Lab, Adelphi, MD 20783 USA. RP Whipps, GT (reprint author), Ohio State Univ, ECE Dept, Columbus, OH 43210 USA. NR 11 TC 0 Z9 0 U1 1 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-0-9824-4386-6 PY 2015 BP 22 EP 27 PG 6 WC Computer Science, Artificial Intelligence; Computer Science, Interdisciplinary Applications; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BG5KW UT WOS:000389523300004 ER PT J AU Verma, D Leland, W Pham, T Swami, A Cirincione, G AF Verma, Dinesh Leland, Will Tien Pham Swami, Ananthram Cirincione, Greg GP IEEE TI Advances in Network Sciences via Collaborative Multi-Disciplinary Research SO 2015 18TH INTERNATIONAL CONFERENCE ON INFORMATION FUSION (FUSION) LA English DT Proceedings Paper CT 18th International Conference on Information Fusion (Fusion) CY JUL 06-09, 2015 CL Washington, DC DE Network Science; Research Alliances AB Network Science is the scientific exploration of the shared fundamental properties underlying different types of networks and their interactions. Two large research alliances, the International Technology Alliance in Network Sciences and the Network Science Collaborative Technology Alliance, have brought together researchers from many diverse disciplines to create fundamental advances in network science. In this paper, we discuss some of the advances made by the scientists in these two research alliances, and some of the lessons learnt as fundamental scientific advances are translated to real networks via military and commercial transitions. Since both of the alliances themselves are complex networks, some of the lessons learnt from management of these networks are also discussed briefly in this paper. C1 [Verma, Dinesh] IBM TJ Watson Res, 1101 Kitchawan Rd, Yorktown Hts, NY 10598 USA. [Leland, Will] Raytheon BBN Technol, 10 Moulton St, Cambridge, MA 02138 USA. [Tien Pham; Swami, Ananthram; Cirincione, Greg] US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Verma, D (reprint author), IBM TJ Watson Res, 1101 Kitchawan Rd, Yorktown Hts, NY 10598 USA. EM dverma@us.ibm.com; wel@bbn.com; tien.pham1.civ@mail.mil; ananthram.swami.civ@mail.mil; gregory.h.cirincione.civ@mail.mil NR 59 TC 0 Z9 0 U1 1 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-0-9824-4386-6 PY 2015 BP 186 EP 193 PG 8 WC Computer Science, Artificial Intelligence; Computer Science, Interdisciplinary Applications; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BG5KW UT WOS:000389523300026 ER PT J AU Pham, T Cirincione, G Swami, A Pearson, G Williams, C AF Pham, Tien Cirincione, Gregory Swami, Ananthram Pearson, Gavin Williams, Christopher GP IEEE TI Distributed Analytics and Information Science SO 2015 18TH INTERNATIONAL CONFERENCE ON INFORMATION FUSION (FUSION) LA English DT Proceedings Paper CT 18th International Conference on Information Fusion (Fusion) CY JUL 06-09, 2015 CL Washington, DC DE analytics; fusion; distributed; networks; security; information processing; military; coalition ID SOFTWARE-DEFINED NETWORKING AB To address future coalition operations in congested, cluttered, contested, connected and constrained battlespace, the US Army Research Laboratory and the UK Defence Science and Technology Laboratory are developing a new research program on Distributed Analytics and Information Science International Technology Alliance. In this paper, we present an overview the two interrelated Technical Areas which when jointly studied will advance the theoretical foundations of distributed analytics and information science in the context of coalition operations. These areas are (1) Dynamic, Secure Coalition Information Infrastructures and (2) Coalition Distributed Analytics and Situational Understanding. C1 [Pham, Tien; Cirincione, Gregory; Swami, Ananthram] US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Pearson, Gavin; Williams, Christopher] Def Sci & Technol Lab, Salisbury SP4 0JQ, Wilts, England. RP Pham, T (reprint author), US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM tien.pham1.civ@mail.mil; gregory.h.cirincione.civ@mail.mil; ananthram.swami.civ@mail.mil; agpearson@mail.dstl.gov.uk; cwilliams@mail.dstl.gov.uk NR 18 TC 0 Z9 0 U1 1 U2 4 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-0-9824-4386-6 PY 2015 BP 245 EP 252 PG 8 WC Computer Science, Artificial Intelligence; Computer Science, Interdisciplinary Applications; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BG5KW UT WOS:000389523300034 ER PT J AU Kaplan, L Ivanovska, M Josang, A Sambo, F AF Kaplan, Lance Ivanovska, Magdalena Josang, Audun Sambo, Francesco GP IEEE TI Towards Subjective Networks: Extending Conditional Reasoning in Subjective Logic SO 2015 18TH INTERNATIONAL CONFERENCE ON INFORMATION FUSION (FUSION) LA English DT Proceedings Paper CT 18th International Conference on Information Fusion (Fusion) CY JUL 06-09, 2015 CL Washington, DC ID PROBABILITIES AB This work expands the concept of conditional reasoning in subjective logic between two variables to reasoning over multiple variables as a step to eventually realize efficient means for inference over subjective networks, i.e. Bayesian networks with uncertain marginal and conditional probabilities. Three new inference methods are introduced for a three node subjective network. Monte Carlo simulations characterize the accuracy of these methods to represent inferred uncertain knowledge about the ground truth. C1 [Kaplan, Lance] US Army, Res Lab, Adelphi, MD 20783 USA. [Ivanovska, Magdalena; Josang, Audun] Univ Oslo, Oslo, Norway. [Sambo, Francesco] Univ Padua, Padua, Italy. RP Kaplan, L (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA. NR 16 TC 1 Z9 1 U1 1 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-0-9824-4386-6 PY 2015 BP 319 EP 326 PG 8 WC Computer Science, Artificial Intelligence; Computer Science, Interdisciplinary Applications; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BG5KW UT WOS:000389523300043 ER PT J AU Oltramari, A Cho, JH AF Oltramari, Alessandro Cho, Jin-Hee GP IEEE TI ComTrustO: Composite Trust-based Ontology Framework for Information and Decision Fusion SO 2015 18TH INTERNATIONAL CONFERENCE ON INFORMATION FUSION (FUSION) LA English DT Proceedings Paper CT 18th International Conference on Information Fusion (Fusion) CY JUL 06-09, 2015 CL Washington, DC DE ontology; composite trust; information fusion; quality-of-service; quality-of-information; social trust; cognition; situation awareness ID ENVIRONMENTS AB Interactions between humans and machines are often placed in a multi-layered network involving the multidimensional trust in communication, information, and socio-cognitive layers. In this complex environment, how to filter and fuse heterogeneous data is critical for effective decision making. In this work, we propose an ontology-based framework for information fusion, as a support system for human decision makers. In particular, we build upon the concept of composite trust, consisting of four trust types: communication trust, information trust, social trust, and cognitive trust. Based on the concept of multidimensional trust, we construct a composite trust ontology framework, called ComTrustO, that embraces four trust ontologies, one for each trust type. We present the details of the integrated ontology framework and discuss a concrete example scenario. C1 [Oltramari, Alessandro] Carnegie Mellon Univ, Pittsburgh, PA 15213 USA. [Cho, Jin-Hee] US Army, Res Lab, Adelphi, MD USA. RP Oltramari, A (reprint author), Carnegie Mellon Univ, Pittsburgh, PA 15213 USA. EM aoltrama@andrew.cmu.edu; jinhee.cho@us.army.mil NR 38 TC 1 Z9 1 U1 2 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-0-9824-4386-6 PY 2015 BP 542 EP 549 PG 8 WC Computer Science, Artificial Intelligence; Computer Science, Interdisciplinary Applications; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BG5KW UT WOS:000389523300073 ER PT J AU Sensoy, M Kaplan, L Ayci, G de Mel, G AF Sensoy, Murat Kaplan, Lance Ayci, Gonul de Mel, Geeth GP IEEE TI FUSE-BEE: Fusion of Subjective Opinions through Behavior Estimation SO 2015 18TH INTERNATIONAL CONFERENCE ON INFORMATION FUSION (FUSION) LA English DT Proceedings Paper CT 18th International Conference on Information Fusion (Fusion) CY JUL 06-09, 2015 CL Washington, DC DE Information Fusion; Subjective Logic; Dirichlet Distributions; Behavior Estimation ID REPUTATION; TRUST AB Information is critical in almost all decision making processes. Therefore, it is important to get the right information at the right time from the right sources. However, information sources may behave differently while providing information i.e., they may provide unreliable, erroneous, noisy, or misleading information deliberately or unintentionally. Motivated by this observation, in this paper, we propose a statistical information fusion approach based on behavior estimation. Our approach transforms the conveyed information into more useful form by tempering them with the estimated behaviors of sources. Through extensive simulations, we have shown that our approach has a lower computational complexity, and achieves significantly low behavior estimation and fusion errors. C1 [Sensoy, Murat; Ayci, Gonul] Ozyegin Univ, Dept Comp Sci, Istanbul, Turkey. [Kaplan, Lance] US Army, Res Lab, Adelphi, MD 20783 USA. [de Mel, Geeth] IBM TJ Watson Res Ctr, Hawthorne, NY USA. RP Sensoy, M (reprint author), Ozyegin Univ, Dept Comp Sci, Istanbul, Turkey. NR 15 TC 1 Z9 1 U1 1 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-0-9824-4386-6 PY 2015 BP 558 EP 565 PG 8 WC Computer Science, Artificial Intelligence; Computer Science, Interdisciplinary Applications; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BG5KW UT WOS:000389523300075 ER PT J AU Chan, K Marcus, K Scott, L Hardy, R AF Chan, Kevin Marcus, Kelvin Scott, Lisa Hardy, Rommie GP IEEE TI Quality of Information Approach to Improving Source Selection in Tactical Networks SO 2015 18TH INTERNATIONAL CONFERENCE ON INFORMATION FUSION (FUSION) LA English DT Proceedings Paper CT 18th International Conference on Information Fusion (Fusion) CY JUL 06-09, 2015 CL Washington, DC AB Intelligence operations in highly dynamic and constrained networked environments require a prudent strategies to query information sources. We consider the performance of this process based on metrics relating to quality of information: accuracy, timeliness, completeness and reliability. These metrics are identified in military doctrine as requirements that promote mission success. Further, it is possible to identify specific network metrics that are indicators of that the network is meeting these quality requirements. We study effective data rate, social distance, link integrity and the utility of information as metrics within a multi-genre network to determine the quality of information of its available sources. This paper proposes a formulation of the analytic hierarchy process to score information sources based on these concepts. A modification to this algorithm is also presented which incorporates the dynamics of the measurements. This is a multimodal fusion approach that considers elements from communications, information and social networks to assist a decision maker in the source selection problem. We show how this approach can be used to score information sources for such tasks using results from representative simulations. C1 [Chan, Kevin; Marcus, Kelvin; Scott, Lisa; Hardy, Rommie] US Army, Res Lab, Adelphi, MD 20783 USA. RP Chan, K (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA. NR 18 TC 1 Z9 1 U1 1 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-0-9824-4386-6 PY 2015 BP 566 EP 573 PG 8 WC Computer Science, Artificial Intelligence; Computer Science, Interdisciplinary Applications; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BG5KW UT WOS:000389523300076 ER PT J AU Deligeorges, S Lavey, C Cakiades, G George, J Wang, Y Ez, FN Doyle, F AF Deligeorges, S. Lavey, C. Cakiades, G. George, J. Wang, Y. Ez, F. N. Doyle, F. GP IEEE TI A Mobile Acoustic Sensor Fusion Network Using Biologically Inspired Sensors and Synchronization SO 2015 18TH INTERNATIONAL CONFERENCE ON INFORMATION FUSION (FUSION) LA English DT Proceedings Paper CT 18th International Conference on Information Fusion (Fusion) CY JUL 06-09, 2015 CL Washington, DC DE Hostile fire detection; sensor fusion; biologically inspired sensors; sensor networks; network synchronization AB Hostile fire detection is a critical component of situational awareness in the asymmetric battlefields of ongoing and future conflicts. The ability to detect and localize sources of hostile fire in difficult environments can dramatically increase the survivability of dismounted warfighters. Existing individual acoustic hostile fire sensors provide useful information but are prone to heading errors, variable bearing and range accuracy, as well as reliability issues due to false alarms, limiting the actionability of the information. The warfighter can have significantly improved hostile fire sensor performance through affirmation fusion. By leveraging existing sensors as a sensor network, the improvements come without additional weight, equipment, or power draw on the already overburdened soldier. Key to this objective is the ability to synchronize sensors over the network accurately, without using large amounts of power or network bandwidth, even when GPS-denied. Bio-inspired synchronization enables the proposed network infrastructure and makes possible sensor fusion algorithms on mobile platforms. C1 [Deligeorges, S.; Lavey, C.] BioMimet Syst, Cambridge, MA 02139 USA. [Cakiades, G.] Picatinny Arsenal, ARDEC, Wharton, NJ USA. [George, J.] Army Res Lab, Adelphi, MD USA. [Wang, Y.] Clemson Univ, Clemson, SC USA. [Ez, F. N.; Doyle, F.] Univ Calif Santa Barbara, Santa Barbara, CA 93106 USA. RP Deligeorges, S (reprint author), BioMimet Syst, Cambridge, MA 02139 USA. EM Socrates@BMSacoustics.com; CathyLavey@BMSacoustics.com; Cakiades.civ@mail.mil; Jemin.George@mail.mil; Yongqiw@clemson.edu; Fenunez@icb.ucsb.edu; Frank.Doyle@icb.ucsb.edu NR 12 TC 0 Z9 0 U1 1 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-0-9824-4386-6 PY 2015 BP 1717 EP 1723 PG 7 WC Computer Science, Artificial Intelligence; Computer Science, Interdisciplinary Applications; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BG5KW UT WOS:000389523300226 ER PT J AU Chowdhury, RA Hosur, MV Nuruddin, M Tcherbi-Narteh, A Kumar, A Boddu, V Jeelani, S AF Chowdhury, Reaz A. Hosur, Mahesh V. Nuruddin, Md. Tcherbi-Narteh, Alfred Kumar, Ashok Boddu, Veera Jeelani, Shaik TI Self-healing epoxy composites: preparation, characterization and healing performance SO JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T LA English DT Article DE Microcapsules; Synthesis; Low velocity impact; Thermography; Healing efficiency AB Low velocity impact damage is common in fiber reinforced composites, which leads to micro-crack and interfacial debonding, where damage is microscopic and invisible. The concept of self-healing composites can be a way of overcoming this limitation and extending the life expectancy while expanding their usage in structural applications. In the current study, extrinsic self-healing concept was adopted using urea-formaldehyde microcapsules containing room temperature curing epoxy resin system (SC-15) as the healing agent prepared by in situ polymerization. Microcapsules were characterized using Fourier transform infrared spectroscopy (FTIR) for structural analysis. Size and shape of microcapsules were studied using optical microscopy and scanning electron microscopy (SEM). Size of the micro capsules was between 30 and 100 mu m. Thermal characterization was carried out using thermogravimetric analysis. Microcapsules were thermally stable till 210 degrees C without any significant decomposition. Fiber reinforced composite fabrication was carried out in three different steps. In the first step, epoxy resin was encapsulated in urea-formaldehyde shell material, which was confirmed by FTIR analysis. In the next step, encapsulation of amine hardener was achieved by vacuum infiltration method. These two different microcapsules were added with epoxy at 10:3 ratio and composite fabrication was done with hand layup method. Finally, healing performance was measured in terms of low velocity impact test and thermoscopy analysis. Low velocity impact test with 30J and 45J impact loads confirmed the delamination and micro-crack in composite materials and subsequent healing recovery observed in terms of damaged area reduction and restoration of mechanical properties. (C) 2014 Brazilian Metallurgical, Materials and Mining Association. Published by Elsevier Editora Ltda. All rights reserved. C1 [Chowdhury, Reaz A.; Hosur, Mahesh V.; Nuruddin, Md.; Tcherbi-Narteh, Alfred; Jeelani, Shaik] Tuskegee Univ, Dept Mat Sci & Engn, Tuskegee, AL 36088 USA. [Kumar, Ashok; Boddu, Veera] US Army Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL USA. RP Hosur, MV (reprint author), Tuskegee Univ, Dept Mat Sci & Engn, Tuskegee, AL 36088 USA. EM hosur@mytu.tuskegee.edu FU U.S. Army ERDC-CERL FX Authors would like to acknowledge the support of U.S. Army ERDC-CERL for the support to carry out this work. NR 15 TC 6 Z9 7 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 2238-7854 EI 2214-0697 J9 J MATER RES TECHNOL JI J. Mater. Res. Technol-JMRT PD JAN-MAR PY 2015 VL 4 IS 1 BP 33 EP 43 DI 10.1016/j.jmrt.2014.10.016 PG 11 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA V46PS UT WOS:000209896700007 ER PT J AU Davis, C Conrath, E Tomanek, M McKay, A AF Davis, Carrie Conrath, Ed Tomanek, Matt McKay, Aldo BE Ingraffea, N Libby, M TI Are Window Mullion Response Limits Too Conservative? SO Structures Congress 2015 LA English DT Proceedings Paper CT Structures Congress CY APR 23-25, 2015 CL Portland, OR SP Amer Soc Civil Engineers, Struct Engn Inst AB Design of blast resistant windows is relatively new compared to other facade components such as steel, concrete, and reinforced masonry, but is slowly coming into its own in terms of design procedures and response criteria. Initial response criteria from the mid 1980s - when design procedures for blast resistant windows were initially formulated - limited window framing to L/264 but no more than 1/8-in. There were also stringent wall response criteria when windows attached directly to walls. These criteria were used because monolithic glazing, limited to low probabilities of fracture, was used. In the 1990s and early 2000s, when laminated glass started to become the glazing for blast resistant windows, software using SDOF approaches allowed for the fracture and even flyout of the glazing - depending on the level of protection to be used. However, frame response was still rather stringent and vacillated between L/60 and L/160 of the frame member. With the publication of the ASCE document on "Blast Protection of Buildings" and the PDC TR 10-02, "Blast Resistant Design Methodology for Window Systems Designed Statically and Dynamically", frame response criteria for windows, storefront systems, and curtain walls became less stringent and varied depending on the level of protection to be used. Recent testing has shown that even the latest response criteria may be somewhat conservative for different levels of protection. The test information is somewhat limited since most window systems are tested to show compliance with different glazing hazard levels/performance conditions, but limited available data where deflection of mullions was tracked during dynamic loading, showed low glazing hazards even though frame response was greater than would be allowed for design. This paper presents a historical perspective of how response limits and glazing design have progressed over the years and then presents available data showing that low glazing hazards against blast loads can be achieved even though the frame response is much greater than the current allowable limits. C1 [Davis, Carrie; McKay, Aldo] Protect Engn Consultants, 14144 Trautwein Rd, Austin, TX 78737 USA. [Conrath, Ed] Protect Engn Consultants, Omaha, NE USA. [Tomanek, Matt] US Army Corps Engineers, Protect Design Ctr, Omaha, NE USA. RP Davis, C (reprint author), Protect Engn Consultants, 14144 Trautwein Rd, Austin, TX 78737 USA. EM cdavis@protection-consultants.com; econrath@protection-consultants.com; Matthew.T.Tomanek@usace.army.mil; amkcay@protection-consultants.com NR 11 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC CIVIL ENGINEERS PI NEW YORK PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 USA BN 978-0-7844-7911-7 PY 2015 BP 1 EP 12 PG 12 WC Construction & Building Technology; Engineering, Civil; Engineering, Mechanical SC Construction & Building Technology; Engineering GA BG8WG UT WOS:000392737000001 ER PT J AU Rowell, SP AF Rowell, Stephen P. BE Ingraffea, N Libby, M TI Performance of Reinforcement Bar Mechanical Couplers at Low, Medium, and High Strain-Rates SO Structures Congress 2015 LA English DT Proceedings Paper CT Structures Congress CY APR 23-25, 2015 CL Portland, OR SP Amer Soc Civil Engineers, Struct Engn Inst AB The Unified Facilities Criteria (UFC) 3-340-02, formerly Army Technical Manual 5-1300/NAVFAC P-397/AFR 88-22 (TM 5-1300), defines the criteria for designing reinforced concrete structures to resist blast effects from accidental explosions. The recent Change 1 to the UFC 3-340-02 included an update to section 4-21.8 "Mechanical Splices of Reinforcement." This update added the validation test requirements and the acceptance criteria for the use of mechanical couplers in place of lap splicing of steel reinforcing bars in elements at specific locations and under certain conditions. Several types of mechanical couplers have been tested and validated for developing the strength of reinforcing steel for cyclic loading and strain-rates expected during earthquakes. However, no mechanical couplers were shown to meet the longstanding section 4-21.8 requirement that the coupler be capable of developing the ultimate dynamic tensile strength of the reinforcing bar under high strain-rate loading without reducing its ductility. This paper presents the results of tests performed by the U.S. Army Engineer Research and Development Center (ERDC) and documented in ERDC Technical Report TR-09-8, "High Strain-Rate Testing of Mechanical Couplers." Five different types of mechanical couplers that meet the American Concrete Institute 318 type II requirements were dynamically tested at low, medium, and high strain-rates to obtain their measured performances. The performances of these mechanical couplers were compared to control bars tested at the same strain-rates. The test results were evaluated to determine if requirements of TM 5-1300 and UFC 3-340-02 were achieved. While the evaluation showed that these five mechanical couplers did not consistently meet the section 4-21.8 requirement for unrestricted use, the tests did demonstrate adequate performance for certain couplers at lower response limits. The recent Change 1 of the UFC 3-340-02 is discussed and compared to the previous requirements to provide the industry guidance and a path forward to further testing and validation of mechanical couplers for use in hardened structures. C1 [Rowell, Stephen P.] US Army Engineer Res & Dev Ctr ERDC, Struct Mech Branch, Geosci & Struct Div, Geotech & Struct Lab,ATTN CEERD GSM, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. RP Rowell, SP (reprint author), US Army Engineer Res & Dev Ctr ERDC, Struct Mech Branch, Geosci & Struct Div, Geotech & Struct Lab,ATTN CEERD GSM, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM stephen.p.rowell@usace.army.mil FU NAVFAC EXWC FX The research reported herein was conducted under the High Strain-Rate Mechanical Coupler Tests project sponsored by NAVFAC EXWC. Mr. Kevin Hager of NAVFAC EXWC served as the Program Manager. Permission from the Director, Geotechnical and Structures Laboratory, and the NAVFAC EXWC to publish this paper is gratefully acknowledged. Approved for public release; distribution is unlimited. NR 6 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CIVIL ENGINEERS PI NEW YORK PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 USA BN 978-0-7844-7911-7 PY 2015 BP 99 EP 114 PG 16 WC Construction & Building Technology; Engineering, Civil; Engineering, Mechanical SC Construction & Building Technology; Engineering GA BG8WG UT WOS:000392737000009 ER PT J AU North, T AF North, Thomas BE Ingraffea, N Libby, M TI Bridge Load Rating Practices for Cranes SO Structures Congress 2015 LA English DT Proceedings Paper CT Structures Congress CY APR 23-25, 2015 CL Portland, OR SP Amer Soc Civil Engineers, Struct Engn Inst AB Oversized and overweight Rough Terrain (RT) and All Terrain (AT) commercial cranes are used extensively at dam projects and continuously cross bridges that serve the requirements of the public agencies or private utilities that own them. Depending on the state jurisdiction, these cranes will be trailered or driven under a variety of local and multistate permit programs. The effects of crane loads on highway bridges are a frequent concern due to the variability in age, design, construction, and condition of the bridges. Currently, the only guidance available for analysis is criteria outlined in AASHTO Load and Resistance Factor Design (LRFD) Bridge Design Specifications and AASHTO Guide Manual for the Condition Evaluation and Load and Resistance Factor Rating of Highway Bridges (LRFR). The information in this presentation will help determine safe loading capacity and placement of three common types of classifications of oversized cranes on a bridge. It is based on vehicular loading and requires an analysis methodology that extrapolates an allowable crane permit loading from the LRFR bridge design or legal loading. The differences between vehicular & crane live and static loads, axle configurations, and load placements are discussed. There are recommendations for making informed decisions on adjustments in impact loads, live load distributions and lane loading based on the Strength II requirements outlined in the evaluation and rating procedures in the AASHTO LRFR and LRFD specifications. This article will also show an outline for planning a crane operation on a bridge that includes consideration of working loads, placement and minimizing risks. C1 [North, Thomas] US Army, Corps Engineers, Northernwestern Div, 1125 NW Couch St,Suite 500, Portland, OR 97209 USA. RP North, T (reprint author), US Army, Corps Engineers, Northernwestern Div, 1125 NW Couch St,Suite 500, Portland, OR 97209 USA. EM thomas.north@usace.army.mil NR 4 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CIVIL ENGINEERS PI NEW YORK PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 USA BN 978-0-7844-7911-7 PY 2015 BP 172 EP 182 PG 11 WC Construction & Building Technology; Engineering, Civil; Engineering, Mechanical SC Construction & Building Technology; Engineering GA BG8WG UT WOS:000392737000015 ER PT B AU Castro, CA Wilcox, SL AF Castro, Carl Andrew Wilcox, Sherrie Leigh BE Powles, A Partow, N Nelson, N TI Mental Health and Combat Veterans SO UNITED NATIONS PEACEKEEPING CHALLENGE: THE IMPORTANCE OF THE INTEGRATED APPROACH SE Global Security in a Changing World LA English DT Proceedings Paper CT 8th Pacific Army Chiefs Conference / 37th Seminar on Pacific Armies Management CY SEP, 2013 CL Auckland, NEW ZEALAND SP New Zealand Army, US Army C1 [Castro, Carl Andrew] Univ Southern Calif, Sch Social Work, Los Angeles, CA 90089 USA. [Castro, Carl Andrew] US Army Med Res Unit Europe, Heidelberg, Germany. [Castro, Carl Andrew] US Army Med Res & Mat Command, Res Program, Walter Reed Army Inst, Dept Mil Psychiat, Ft Detrick, MD USA. [Wilcox, Sherrie Leigh] USC, Sch Social Work, Los Angeles, CA USA. [Wilcox, Sherrie Leigh] USC, Ctr Innovat & Res Vet & Mil Families, Los Angeles, CA USA. RP Castro, CA (reprint author), Univ Southern Calif, Sch Social Work, Los Angeles, CA 90089 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-47-243247-6; 978-1-47-243246-9 J9 GLOB SECUR CHANG WOR PY 2015 BP 149 EP 166 PG 18 WC International Relations SC International Relations GA BG6UT UT WOS:000390845200013 ER PT B AU Flavin, W AF Flavin, William BE Powles, A Partow, N Nelson, N TI Teaming for Success SO UNITED NATIONS PEACEKEEPING CHALLENGE: THE IMPORTANCE OF THE INTEGRATED APPROACH SE Global Security in a Changing World LA English DT Proceedings Paper CT 8th Pacific Army Chiefs Conference / 37th Seminar on Pacific Armies Management CY SEP, 2013 CL Auckland, NEW ZEALAND SP New Zealand Army, US Army C1 [Flavin, William] US Army War Coll, US Army Peacekeeping & Stabil Operat Inst PKSOI, Carlisle, PA 17013 USA. [Flavin, William] PKSOI, Doctrine & Educ Div, Carlisle, PA USA. [Flavin, William] Booz Allen & Hamilton Inc, Mclean, VA USA. [Flavin, William] Ctr Strateg & Int Studies, Washington, DC 20006 USA. [Flavin, William] Army War Coll, Carlisle, PA USA. RP Flavin, W (reprint author), US Army War Coll, US Army Peacekeeping & Stabil Operat Inst PKSOI, Carlisle, PA 17013 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-47-243247-6; 978-1-47-243246-9 J9 GLOB SECUR CHANG WOR PY 2015 BP 217 EP 233 PG 17 WC International Relations SC International Relations GA BG6UT UT WOS:000390845200017 ER PT J AU Cotter, JL Rael, JS AF Cotter, J. L. Rael, J. S. BE Karvazy, K Webster, VL TI History of Federal Dam Construction in Texas SO World Environmental and Water Resources Congress 2015: Floods, Droughts, and Ecosystems LA English DT Proceedings Paper CT World Environmental and Water Resources Congress CY MAY 17-21, 2015 CL Austin, TX SP Amer Soc Civil Engineers, Environm and Water Resources Inst C1 [Cotter, J. L.; Rael, J. S.] US Army Corps Engn, Water Resource Branch, 819 Taylor St, Ft Worth, TX 76102 USA. RP Cotter, JL (reprint author), US Army Corps Engn, Water Resource Branch, 819 Taylor St, Ft Worth, TX 76102 USA. EM Jerry.L.Cotter@usace.army.mil; John.S.Rael@usace.army.mil NR 14 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC CIVIL ENGINEERS PI NEW YORK PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 USA BN 978-0-7844-7916-2 PY 2015 BP 74 EP 94 PG 21 WC Engineering, Civil; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA BG8ZE UT WOS:000392856300008 ER PT J AU Davis, DW Fredrich, AJ AF Davis, Darryl W. Fredrich, Augustine J. BE Karvazy, K Webster, VL TI The Hydrologic Engineering Center-50 Years of Hydrologic Engineering History SO World Environmental and Water Resources Congress 2015: Floods, Droughts, and Ecosystems LA English DT Proceedings Paper CT World Environmental and Water Resources Congress CY MAY 17-21, 2015 CL Austin, TX SP Amer Soc Civil Engineers, Environm and Water Resources Inst AB The Hydrologic Engineering Center (HEC) was founded in 1964 by the U.S. Army Corps of Engineers (USACE 1989). Digital computers were just becoming widely available and the founders quickly recognized the potential for automating laborious manual calculations and extending applications to problems not here-to-fore practical. Their shared vision of achieving economy and consistency in hydrologic analysis and in exploiting the use of digital computers resulted in the creation of the discipline known today as hydrologic engineering and the Hydrologic Engineering Center as the organizational vehicle for making their vision a reality. HEC was created as a three-pronged organization designed to achieve the goal of improving USACE capability for hydrologic engineering. The three elements of the HEC mission were methods systemization and training, research, and special assistance. The three elements of the mission were integrated to provide feedback from users in Corps field offices to HEC so that the work at HEC remained focused on the needs of engineers engaged in real-world problem solving. The size of HEC has remained remarkably constant over the years - about 35 permanent staff plus a complement of students. In its 50-year history the Hydrologic Engineering Center has been a model for the development of technical expertise and knowledge sharing. Its work has been acclaimed by many and emulated by others in both the public and private sectors, and it stands as a singular example of how the vision of its founders could endure through half a century of technological changes that surpassed even their greatest expectations of what the profession of hydrologic engineering could become. C1 [Davis, Darryl W.] US Army Corps Engineers, Inst Water Resources, 801 Malaga Ave, Davis, CA 95616 USA. [Fredrich, Augustine J.] Univ Southern Indiana, Engn, Little Rock, AR 72212 USA. RP Davis, DW (reprint author), US Army Corps Engineers, Inst Water Resources, 801 Malaga Ave, Davis, CA 95616 USA. EM Darryl.W.Davis@usace.army.mil; ajfredrich@gmail.com NR 10 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CIVIL ENGINEERS PI NEW YORK PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 USA BN 978-0-7844-7916-2 PY 2015 BP 161 EP 170 PG 10 WC Engineering, Civil; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA BG8ZE UT WOS:000392856300015 ER PT J AU Weston, DM Skahill, BE Downer, CW Graulau-Santiago, JA Pradhan, N Byrd, AR AF Weston, David M. Skahill, Brian E. Downer, Charles W. Graulau-Santiago, Jaime A. Pradhan, Nawa Byrd, Aaron R. BE Karvazy, K Webster, VL TI Gridded Surface Subsurface Hydrologic Analysis Modeling for Analysis of Flood Design Features at the Picayune Strand Restoration Project SO World Environmental and Water Resources Congress 2015: Floods, Droughts, and Ecosystems LA English DT Proceedings Paper CT World Environmental and Water Resources Congress CY MAY 17-21, 2015 CL Austin, TX SP Amer Soc Civil Engineers, Environm and Water Resources Inst ID PREDICTION INTERVALS; CONFIDENCE AB The Picayune Strand Restoration Project is one of many components of the Comprehensive Everglades Restoration Project (CERP) intended to restore nearly 55,000 acres (22,258 hectare) of a failed residential development in southwestern Collier County, Florida, to its pre-development wetland conditions. A detailed analysis was preformed to derive a restoration plan that will achieve this goal. As required by the Water Resources Development Act (WRDA) 2000, the US Army Corps of Engineers (USACE) is required to ensure that no component of CERP results in an effective taking of land by adversely impacting the level of flood protection of adjacent landowners. To ensure the current level of flood protection is maintained, a hydrologic model was developed to assess the potential for flooding and help with the refinement of the proposed flood mitigation features. The USACE physically-based Gridded Sub-Surface Hydrologic Analysis (GSSHA) model was selected for this effort. The GSSHA model simulates fully coupled rainfall distribution, extraction, retention, overland flow, and one dimensional channel flow. The GSSHA model also has the capability of developing inset sub-models within the boundaries of a larger model domain (telescopic refinement) which allows for high resolution analysis of the hydrologic process being simulated. The inclusion of overland flow rating curves allowed critical hydraulic elements to be simulated with a reasonable model resolution. The models were developed from existing and design data, and initially populated with parameter values from a previous hydrodynamic modeling effort. Parameters were then tuned to observed stage data using the Secant Levenberg-Marquardt (SLM) method, a nonlinear least squares minimization computer-based local search method. The calibrated model is capable of reproducing canal flows, canal stages, and overland stages with very high Nash Sutcliffe Forecast Efficiencies, generally 0.9 or higher. Subsequent uncertainty analysis allowed water stages to be estimated with 95% certainty. The water level results and the uncertainty analysis allowed for the design refinement of the proposed flood mitigation features. The hydrologic models and analysis demonstrated that some of these features were either unnecessary or over-designed with respect to the original design. C1 [Weston, David M.; Graulau-Santiago, Jaime A.] US Army, Adelphi, MD 20483 USA. [Skahill, Brian E.; Downer, Charles W.; Pradhan, Nawa; Byrd, Aaron R.] US Army, Engn Res & Dev Ctr, Coastal & Hydraul Lab, Adelphi, MD 20483 USA. RP Weston, DM (reprint author), US Army, Adelphi, MD 20483 USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CIVIL ENGINEERS PI NEW YORK PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 USA BN 978-0-7844-7916-2 PY 2015 BP 1500 EP 1511 PG 12 WC Engineering, Civil; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA BG8ZE UT WOS:000392856300147 ER PT J AU Ramos, K Gibson, S Kavvas, LM Heath, R Sharp, J AF Ramos, Kervi Gibson, Stanford Kavvas, Levent M. Heath, Ronnie Sharp, Jeremy BE Karvazy, K Webster, VL TI Estimating Bed-Load Advection And Dispersion Coefficients With The Method Of Moments SO World Environmental and Water Resources Congress 2015: Floods, Droughts, and Ecosystems LA English DT Proceedings Paper CT World Environmental and Water Resources Congress CY MAY 17-21, 2015 CL Austin, TX SP Amer Soc Civil Engineers, Environm and Water Resources Inst ID TRANSPORT AB The Advection Dispersion (AD) equation is commonly used to simulate solute, wash load, and even suspended load transport, but is rarely applied to bed load. The obstacle to applying AD equation to bed load transport is empirical; it is challenging to estimate the advection and diffusion coefficients. This paper applies the method of moments to a flume experiment to compute the AD bed load coefficients. Five colors of otherwise identical sand were introduced into an equilibrium sediment flume in sequence. After the experiment, surface, bed samples were collected along the length of the flume and sieved into eight-grain classes. Color distributions of each sample and each grain class were computed with image analysis. Longitudinal Probability Mass Function (PMF) of each color and each grain class were computed from these data. The method of moments was applied to the PMF of the particle displacements, where the advection coefficient was the temporal derivative of the first moment of each color and, the diffusion coefficient was defined as the temporal derivative of the variance. In this paper, advection and dispersion coefficients are computed for coarse sand material that consists of mean diameter of 1.3mm C1 [Ramos, Kervi; Gibson, Stanford] US Army, Corps Engineers, Hydrol Engn Ctr, Inst Water Resources, 609 Second St, Davis, CA 95616 USA. [Kavvas, Levent M.] Univ Calif Davis, Dept Civil & Environm Engn, Davis, CA 95616 USA. [Heath, Ronnie; Sharp, Jeremy] US Army, Corps Engineers, Engn Res & Dev Ctr, Costal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Ramos, K (reprint author), US Army, Corps Engineers, Hydrol Engn Ctr, Inst Water Resources, 609 Second St, Davis, CA 95616 USA. EM Kervi.Ramos@usace.mil; Stanford.Gibson@usace.army.mil; leventkavvas@sbcglobal.net; Ronald.E.Heath@erdc.dren.mil; Jeremy.Sharp@usace.army.mil FU US Army Corps of Engineers' Flood; Coastal Storm Damage Reduction RD Program FX This work was funded by the US Army Corps of Engineers' Flood and Coastal Storm Damage Reduction R&D Program. Glen Lischeske sieved the samples and conducted the image analysis for this experiment. NR 9 TC 2 Z9 2 U1 0 U2 0 PU AMER SOC CIVIL ENGINEERS PI NEW YORK PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 USA BN 978-0-7844-7916-2 PY 2015 BP 1736 EP 1741 PG 6 WC Engineering, Civil; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA BG8ZE UT WOS:000392856300169 ER PT J AU Dunn, CN Baker, PR AF Dunn, Christopher N. Baker, Penni R. BE Karvazy, K Webster, VL TI Converting Real-Time Water Management Models for Use in Water Resources Studies SO World Environmental and Water Resources Congress 2015: Floods, Droughts, and Ecosystems LA English DT Proceedings Paper CT World Environmental and Water Resources Congress CY MAY 17-21, 2015 CL Austin, TX SP Amer Soc Civil Engineers, Environm and Water Resources Inst AB The U.S. Army Corps of Engineers (USACE) has been tasked to complete project studies more quickly without sacrificing model fidelity and to shift to a watershed and systems-based approach for decision making that incorporates risk analysis. These requirements are central to the USACE Civil Works and Planning Transformation Objectives. While tools exist to address these requirements, those tools have not been universally adopted. After the 2010 and 2011 floods, USACE initiated a plan to build real-time Corps Water Management System (CWMS) watersheds (212) throughout the Nation where USACE has a water management responsibility. One of the key reasons USACE management accepted the plan was that construction of CWMS models benefited other USACE mission areas. One benefit was that the CWMS models could be readily converted to planning models. Preliminary results indicated that the planning process could be shortened significantly if CWMS models were available early in the planning process. USACE performed a detailed study of three basins where CWMS models were converted to HEC-WAT (Watershed Analysis Tools) models. This paper will summarize the study and indicate that starting with CWMS watersheds; significant efficiencies are created thereby supporting the USACE goal of streamlining the planning process while still using detailed modeling. C1 [Dunn, Christopher N.; Baker, Penni R.] US Army Corps Engineers, Hydrol Engn Ctr, Inst Water Resources, 609 Second St, Davis, CA 95616 USA. RP Dunn, CN (reprint author), US Army Corps Engineers, Hydrol Engn Ctr, Inst Water Resources, 609 Second St, Davis, CA 95616 USA. EM christopher.n.dunn@usace.army.mil; penni.r.baker@usace.army.mil NR 7 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CIVIL ENGINEERS PI NEW YORK PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 USA BN 978-0-7844-7916-2 PY 2015 BP 2091 EP 2100 PG 10 WC Engineering, Civil; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA BG8ZE UT WOS:000392856300206 ER PT J AU Manous, JD AF Manous, Joe D., Jr. BE Karvazy, K Webster, VL TI Critical Infrastructure - Preparing for the "Long Haul" SO World Environmental and Water Resources Congress 2015: Floods, Droughts, and Ecosystems LA English DT Proceedings Paper CT World Environmental and Water Resources Congress CY MAY 17-21, 2015 CL Austin, TX SP Amer Soc Civil Engineers, Environm and Water Resources Inst AB Critical infrastructure and sustainability have become key terms within the infrastructure design and governance communities over the past decade. This paper seeks to address issues related to sustainability and engineering design professionals by identifying key areas of need required from practitioners and academicians to chart a course for the long term. The 2011 terrorist attacks on the United States galvanized discussion on critical infrastructure and, as importantly, provided funding to explore new ideas and methods. The consequences of Hurricanes Katrina and Rita in 2005 further shaped these discussions with an increased focus on water infrastructure. While additional "events" have facilitated the development of new ideas, academia has also responded by creating new courses and fields of study. Although these efforts are important and moving forward, they are in their infancy. It is important to recognize that while efforts to develop a disciplinary field in these areas have begun, the efforts are independent and lack consistency of direction. There is a need for national-level leadership, but the source of such leadership is not clear. C1 [Manous, Joe D., Jr.] US Army Corps Engineers, Inst Water Resources, 7701 Telegraph Rd, Alexandria, VA 22315 USA. RP Manous, JD (reprint author), US Army Corps Engineers, Inst Water Resources, 7701 Telegraph Rd, Alexandria, VA 22315 USA. EM Joe.Manous@usace.army.mil NR 12 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CIVIL ENGINEERS PI NEW YORK PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 USA BN 978-0-7844-7916-2 PY 2015 BP 2293 EP 2299 PG 7 WC Engineering, Civil; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA BG8ZE UT WOS:000392856300226 ER PT J AU Fleming, PEMJ Duren, PEA AF Fleming, Matthew J. P. E. Duren, Angela P. E. BE Karvazy, K Webster, VL TI Stochastic Hydrologic Simulation for Extension of Reservoir Pool Stage Frequency Curves SO World Environmental and Water Resources Congress 2015: Floods, Droughts, and Ecosystems LA English DT Proceedings Paper CT World Environmental and Water Resources Congress CY MAY 17-21, 2015 CL Austin, TX SP Amer Soc Civil Engineers, Environm and Water Resources Inst AB A reservoir pool stage frequency curve, including an estimate of the 90-percent confidence limits, is required from the hydrologic analysis for a dam safety study. This information, in combination with estimates of potential dam failure scenarios, is used as a basis for estimating risk (which is comprised of the probability of occurrence and the associated consequences). In general, the pool stage frequency curve must be extended to peak elevations not yet experienced in the reservoir, such as the peak pool elevation generated by the Probable Maximum Flood (PMF) event. The pool stage frequency curve is used, along with hydraulic and consequence modeling, to estimate the damage and life loss for various possible failure modes of a dam. Dams are ranked in a priority order based on the amount of damage/life loss and the probability of failure. Extending the reservoir pool stage frequency curve out to the peak elevations not yet experienced by the reservoir is challenging due to the assumptions and uncertainties of routing synthetic events, including the PMF, through the reservoir. Due to unavailable tools or the inaccessibility of existing tools, the probabilities and associated uncertainties of the parameters and assumptions that is required for determining the peak pool elevation of a synthetic event are generally not accounted for in a pool stage frequency curve. In most cases, the exceedance probability assigned to the balanced hydrograph is also applied to a computed peak stage (with no accounting for the probability of the input parameters combined with the corresponding antecedent condition). New tools are under development at the Hydrologic Engineering Center (CEIWR-HEC) that provides the capability to evaluate these uncertainties in model assumptions and parameters. C1 [Fleming, Matthew J. P. E.] US Army Corps Engineers, Hydrol Engn Ctr, Inst Water Resources, Hydrol & Hydraul Technol Div, 609 Second St, Davis, CA 95616 USA. [Duren, Angela P. E.] US Army Corps Engineers, Portland, OR 97209 USA. RP Fleming, PEMJ (reprint author), US Army Corps Engineers, Hydrol Engn Ctr, Inst Water Resources, Hydrol & Hydraul Technol Div, 609 Second St, Davis, CA 95616 USA. EM matthew.j.fleming@usace.army.mil NR 3 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CIVIL ENGINEERS PI NEW YORK PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 USA BN 978-0-7844-7916-2 PY 2015 BP 2648 EP 2657 PG 10 WC Engineering, Civil; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA BG8ZE UT WOS:000392856300260 ER PT J AU Cap, A Hunt, BJ AF Cap, A. Hunt, B. J. TI The pathogenesis of traumatic coagulopathy SO ANAESTHESIA LA English DT Review ID ACTIVATED PROTEIN-C; DISSEMINATED INTRAVASCULAR COAGULATION; LIFE-THREATENING HEMORRHAGE; FRESH WHOLE-BLOOD; 1ST 24 HOURS; MASSIVE TRANSFUSION; TRANEXAMIC ACID; HEMOSTATIC RESUSCITATION; MAJOR TRAUMA; ROTATION THROMBELASTOGRAPHY AB Over the last 10years, the management of major haemorrhage in trauma patients has changed radically. This is mainly due to the recognition that many patients who are bleeding when they come in to the emergency department have an established coagulopathy before the haemodilution effects of fluid resuscitation. This has led to the use of new terminology: acute traumatic coagulopathy, acute coagulopathy of trauma shock or trauma-induced coagulopathy. The recognition of acute traumatic coagulopathy is important, because we now understand that its presence is a prognostic indicator, as it is associated with poor clinical outcome. This has driven a change in clinical management, so that the previous approach of maintaining an adequate circulating volume and oxygen carrying capacity before, as a secondary event, dealing with coagulopathy, has changed to haemostatic resuscitation as early as possible. While there is as yet no universally accepted assay or definition, many experts use prolongation of the prothrombin time to indicate that there is, indeed, a coagulopathy. Hypoxia, acidosis and hypothermia and hormonal, immunological and cytokine production, alongside consumption and blood loss, and the dilutional effects of resuscitation may occur to varying extents depending on the type of tissue damaged, the type and extent of injury, predisposing to, or amplifying, activation of coagulation, platelets, fibrinolysis. These are discussed in detail within the article. C1 [Cap, A.] US Army, Med Corps, Sam Houston, TX USA. [Cap, A.] Uniformed Serv Univ Hlth Sci, Blood Res Program, US Army Inst Surg Res, Sam Houston, TX USA. [Hunt, B. J.] Guys & St Thomas NHS Fdn Trust, Dept Haematol, London, England. [Hunt, B. J.] Guys & St Thomas NHS Fdn Trust, Dept Pathol, London, England. [Hunt, B. J.] Guys & St Thomas NHS Fdn Trust, Dept Lupus, London, England. RP Hunt, BJ (reprint author), Guys & St Thomas NHS Fdn Trust, Dept Haematol, London, England. EM beverley.hunt@gstt.nhs.uk NR 92 TC 18 Z9 19 U1 1 U2 23 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0003-2409 EI 1365-2044 J9 ANAESTHESIA JI Anaesthesia PD JAN PY 2015 VL 70 SU 1 SI SI DI 10.1111/anae.12914 PG 9 WC Anesthesiology SC Anesthesiology GA AU8JU UT WOS:000345843500015 PM 25440402 ER PT J AU Wilkinson, JP Boyd, T Hagen, B Maksym, T Pegau, S Roman, C Singh, H Zabilansky, L AF Wilkinson, J. P. Boyd, T. Hagen, B. Maksym, T. Pegau, S. Roman, C. Singh, H. Zabilansky, L. TI Detection and quantification of oil under sea ice: The view from below SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article DE Arctic; Oil spill; Sea ice; Oil detection; Sonar; Camera AB Traditional measures for detecting oil spills in the open-ocean are both difficult to apply and less effective in ice-covered seas. In view of the increasing levels of commercial activity in the Arctic, there is a growing gap between the potential need to respond to an oil spill in Arctic ice-covered waters and the capability to do so. In particular, there is no robust operational capability to remotely locate oil spilt under or encapsulated within sea ice. To date, most research approaches the problem from on or above the sea ice, and thus they suffer from the need to 'see' through the ice and overlying snow. Here we present results from a large-scale tank experiment which demonstrate the detection of oil beneath sea ice, and the quantification of the oil layer thickness is achievable through the combined use of an upward-looking camera and sonar deployed in the water column below a covering of sea ice. This approach using acoustic and visible measurements from below is simple and effective, and potentially transformative with respect to the operational response to oil spills in the Arctic marine environment. These results open up a new direction of research into oil detection in ice-covered seas, as well as describing a new and important role for underwater vehicles as platforms for oil-detecting sensors under Arctic sea ice. (C) 2014 The Authors. Published by Elsevier B.V. C1 [Wilkinson, J. P.] British Antarctic Survey, Cambridge CB3 0ET, England. [Boyd, T.; Hagen, B.] Scottish Assoc Marine Sci, Oban PA37 1QA, Argyll, Scotland. [Maksym, T.; Singh, H.] Woods Hole Oceanog Inst, Woods Hole, MA 02543 USA. [Pegau, S.] Oil Spill Recovery Inst, Cordova, AK USA. [Roman, C.] Univ Rhode Isl, Kingston, RI 02881 USA. [Zabilansky, L.] Cold Reg Res Lab, Hanover, NH USA. RP Wilkinson, JP (reprint author), British Antarctic Survey, High Cross Madingley Rd, Cambridge CB3 0ET, England. EM jpw28@bas.ac.uk FU Prince William Sound Oil Spill Recovery Institute (OSRI) [11-10-09]; EU [265863] FX This work was funded through a competitive grant for the detection of oil under ice obtained from Prince William Sound Oil Spill Recovery Institute (OSRI) (11-10-09). Additional funding/resources was obtained through the EU FP7 funded ACCESS programme (Grant Agreement no. 265863). NR 25 TC 1 Z9 1 U1 5 U2 38 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X EI 1872-7441 J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD JAN PY 2015 VL 109 BP 9 EP 17 DI 10.1016/j.coldregions.2014.08.004 PG 9 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA AU5LG UT WOS:000345647900002 ER PT J AU Zhang, LL Jasa, J Gazonas, G Jerusalem, A Negahban, M AF Zhang, Lili Jasa, John Gazonas, George Jerusalem, Antoine Negahban, Mehrdad TI Extracting continuum-like deformation and stress from molecular dynamics simulations SO COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING LA English DT Article DE Molecular dynamics; Multi-scale; Deformation; Deformation gradients; Stress; Minimization ID ATOMIC-LEVEL STRESS; POTASSIUM CHANNEL; SYSTEM EQUIVALENCE; VIRIAL STRESS; DEFINITIONS; TENSOR; MD AB We present methods that use results from molecular dynamics (MD) simulations to construct continuum parameters, such as deformation gradient and Cauchy stress, from all or any part of an MD system. These parameters are based on the idea of minimizing the difference between MD measures for deformation and traction and their continuum counterparts. The procedures should be applicable to non-equilibrium and inhomogeneous systems, and to any part of a system, such as a polymer chain. The resulting procedures provide methods to obtain first and higher order deformation gradients associated with any subset of the MD system, and associated expressions for the Cauchy and nominal stresses. As these procedures are independent of the type of interactions, they can be used to study any MD simulation in a manner consistent with continuum mechanics and to extract information exploitable at the continuum scale to help construct continuum-level constitutive models. (C) 2014 Elsevier B.V. All rights reserved. C1 [Jasa, John; Negahban, Mehrdad] Univ Nebraska, Dept Mech & Mat Engn, Lincoln, NE 68588 USA. [Gazonas, George] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Zhang, Lili; Jerusalem, Antoine] Univ Oxford, Dept Engn Sci, Oxford OX1 3PJ, England. RP Negahban, M (reprint author), Univ Nebraska, W311 NH, Lincoln, NE 68588 USA. EM mnegahban@unl.edu OI Gazonas, George/0000-0002-2715-016X; Jerusalem, Antoine/0000-0001-5026-8038 FU US Army Research Laboratory [W911NF-11-D-0001-0094]; European Research Council under the European Union's Seventh Framework Program (FP7)/ERC [306587]; Undergraduate Creative Activities and Research Experience (UCARE) program at the University of Nebraska-Lincoln FX The research has been partially supported by the US Army Research Laboratory through Contract Number W911NF-11-D-0001-0094. Lili Zhang and Antoine Jerusalem acknowledge funding from the European Research Council under the European Union's Seventh Framework Program (FP7 2007-2013)/ERC Grant Agreement No. 306587. John Jasa would like to acknowledge the support of the Undergraduate Creative Activities and Research Experience (UCARE) program at the University of Nebraska-Lincoln. NR 39 TC 0 Z9 0 U1 5 U2 32 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0045-7825 EI 1879-2138 J9 COMPUT METHOD APPL M JI Comput. Meth. Appl. Mech. Eng. PD JAN 1 PY 2015 VL 283 BP 1010 EP 1031 DI 10.1016/j.cma.2014.10.018 PG 22 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications; Mechanics SC Engineering; Mathematics; Mechanics GA AU8PM UT WOS:000345858700042 ER PT J AU Ananworanich, J Mellors, JW AF Ananworanich, Jintanat Mellors, John W. TI A cure for HIV: what will it take? SO CURRENT OPINION IN HIV AND AIDS LA English DT Editorial Material ID LATENT RESERVOIR; CCR5 C1 [Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Mellors, John W.] Univ Pittsburgh, Pittsburgh, PA USA. RP Ananworanich, J (reprint author), US Mil HIV Res Program, 6720A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA. EM jananworanich@hivresearch.org FU NICHD NIH HHS [R01HD080435-01] NR 10 TC 3 Z9 3 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1746-630X EI 1746-6318 J9 CURR OPIN HIV AIDS JI Curr. Opin. HIV AIDS PD JAN PY 2015 VL 10 IS 1 BP 1 EP 3 DI 10.1097/COH.0000000000000125 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AU9TY UT WOS:000345938600001 PM 25389807 ER PT J AU Ananworanich, J Dube, K Chomont, N AF Ananworanich, Jintanat Dube, Karine Chomont, Nicolas TI How does the timing of antiretroviral therapy initiation in acute infection affect HIV reservoirs? SO CURRENT OPINION IN HIV AND AIDS LA English DT Review DE acute HIV infection; early antiretroviral therapy; HIV DNA; HIV reservoir; replication-competent virus ID CD4(+) T-CELLS; IMMUNE-RESPONSES; SAMHD1; PERSISTENCE; SUBSETS; VIREMIA; DECAY; ESTABLISHMENT; DRIVEN; VIRUS AB Purpose of review The long-lived viral reservoir is a major obstacle to achieving a cure for HIV. Therapeutic strategies, such as early antiretroviral therapy (ART), may be a prerequisite to achieving long-term control of viral replication upon ART withdrawal. Recent findings HIV persistence is established early in acute HIV infection (AHI) with infection in long-lived memory CD4(+) T cells. Studies conducted in nonhuman primates have suggested that this could occur as early as 3 days postinfection; however, the timing in humans is uncertain. ART during AHI significantly restricts the HIV reservoirs as compared with later treatment. Early ART, particularly prior to the detection of HIV immunoglobulin M, may also reduce the contribution of the long-lived central memory CD4(+) T cells to the total HIV reservoir, a profile observed in individuals who naturally control HIV without ART. Summary It is clear that early ART has a greater impact in limiting the HIV reservoirs than later treatment. However, latently infected long-lived memory CD4(+) T cells persist in most early treated individuals. Therefore, additional interventions will likely be required to eliminate all cells capable of producing replication-competent virus but treatment in AHI may be the critical first step in containing the HIV reservoirs. C1 [Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Dube, Karine] Univ N Carolina, Chapel Hill, NC USA. [Chomont, Nicolas] Vaccine & Gene Therapy Inst Florida, Port St Lucie, FL USA. RP Ananworanich, J (reprint author), US Mil HIV Res Program, 6720A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA. EM Jananworanich@hivresearch.org FU amfAR (ARCHE) [108687-54, 108928-56]; National Institutes of Health [1R21 AI113096-01, 1U19AI096109]; National Institute of Allergy and Infectious Diseases [R01HD080435-01]; CARE - Collaboratory of AIDS Researchers for Eradication [U19AI096113] FX The given work was supported in part by grants to N.C. from the amfAR (ARCHE grants 108687-54 and 108928-56), the National Institutes of Health (1R21 AI113096-01 and 1U19AI096109 - DARE: Delaney AIDS research enterprise to find a cure) and a grant to J.A. from the National Institute of Allergy and Infectious Diseases (R01HD080435-01). This work was also partly supported by the CARE - Collaboratory of AIDS Researchers for Eradication (U19AI096113); David M. Margolis PI. NR 44 TC 25 Z9 25 U1 0 U2 17 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1746-630X EI 1746-6318 J9 CURR OPIN HIV AIDS JI Curr. Opin. HIV AIDS PD JAN PY 2015 VL 10 IS 1 BP 18 EP 28 DI 10.1097/COH.0000000000000122 PG 11 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AU9TY UT WOS:000345938600004 PM 25415421 ER PT J AU Goetz, FA Jeanes, E Moore, ME Quinn, TP AF Goetz, Fred A. Jeanes, Eric Moore, Megan E. Quinn, Thomas P. TI Comparative migratory behavior and survival of wild and hatchery steelhead (Oncorhynchus mykiss) smolts in riverine, estuarine, and marine habitats of Puget Sound, Washington SO ENVIRONMENTAL BIOLOGY OF FISHES LA English DT Article DE Behavior; Migration; Oncorhynchus mykiss; Survival; Telemetry ID ATLANTIC SALMON SMOLTS; BRITISH-COLUMBIA; SOCKEYE-SALMON; CHINOOK SALMON; PACIFIC SALMON; DETECTION PROBABILITIES; MARKED ANIMALS; NORTH-AMERICA; KEOGH RIVER; TROUT AB Declines in the survival of steelhead (Oncorhynchus mykiss) populations in protected waters of Washington and British Columbia have drawn attention to the need for more information on migratory patterns and losses in river, estuary, and nearshore habitats. Accordingly, acoustic telemetry was used to quantify movements by wild and hatchery steelhead smolts released from 2006 to 2009 in the Green River, and tracked through Puget Sound, Washington. Survival varied by release group and migration segment but overall survival rates from release to the Strait of Juan de Fuca were 9.7 % for wild and 3.6 % for hatchery fish. These rates are low relative to similar studies on steelhead. Survival was higher for wild fish along all migration segments than hatchery-origin fish; the greatest loss for both groups coincided with the slowest travel rates as fish first entered the estuary and as they exited Puget Sound. Wild fish travelled faster than hatchery fish in the river (15.1 vs. 4.4 km/d) with the fastest travel in the lower river (41 vs. 20.2 km/d) and slowest immediately after release (3.7 vs. 2.4 km/d). The travel rates of wild and hatchery fish became progressively more similar over time: 15.4 vs. 10.6 km/d in the estuary, and 10.3 vs. 9.3 km/d in nearshore areas. Movement was primarily nocturnal in the river, nearly equal between day and night in the upper estuary, and predominately diurnal in the lower estuary and nearshore waters, with no difference between wild and hatchery fish. The migration in marine water showed an early offshore movement and a strong northward and westward orientation, and all fish exited the Strait of Juan de Fuca rather than the Strait of Georgia. The findings support research suggesting that declines in wild and hatchery steelhead populations may be caused primarily by factors in the early marine period. C1 [Goetz, Fred A.] US Army Corps Engineers, Seattle, WA 98134 USA. [Goetz, Fred A.; Quinn, Thomas P.] Univ Washington, Sch Aquat & Fishery Sci, Seattle, WA 98105 USA. [Jeanes, Eric] R2 Resource Consultants, Redmond, WA 98052 USA. [Moore, Megan E.] Natl Ocean & Atmospher Adm Fisheries, Resource Enhancement & Utilizat Technol Div, NW Fisheries Sci Ctr, Manchester, WA 98353 USA. RP Goetz, FA (reprint author), US Army Corps Engineers, POB 3755, Seattle, WA 98134 USA. EM fgoetz@comcast.net FU Washington Department of Fish and Wildlife (WDFW); Seattle District US Army Corps of Engineers (USACE); H. Mason Keeler Endowment; Steelhead Trout Club of Washington (STC); King County Department of Natural Resources (KCDNR); Seattle City Light (SCL); Seattle Aquarium (SA); NOAA Fisheries; Pacific Ocean Shelf Tracking (POST); Hydrophone Data Repository (HYDRA) FX This study was supported by funding and/or in-kind assistance by the Washington Department of Fish and Wildlife (WDFW), Seattle District US Army Corps of Engineers (USACE), H. Mason Keeler Endowment to the University of Washington, Steelhead Trout Club of Washington (STC), King County Department of Natural Resources (KCDNR), Seattle City Light (SCL), Seattle Aquarium (SA), NOAA Fisheries, Pacific Ocean Shelf Tracking (POST), and Hydrophone Data Repository (HYDRA). This study was reviewed and approved by the University of Washington's Institutional Animal Care and Use Committee. We thank Bob Leland, Kelly Kiyohara, Pat Michael, Brody Antipa, Pete Topping, and Deborah Feldman of the WDFW for their efforts in project planning, smolt collection, hatchery rearing, tagging, and receiver deployment; Hal Boynton, John Kelly, Ed Conroy and other members of the STC for their enthusiasm and support; Kelly Andrews (NOAA Fisheries), Ed Connor (SCL), John Blaine and Jim Devereaux (KCNDR) for their assistance; Correigh Greene (NOAA), Shawn Larson and Jeff Christiansen (SA), Chuck Ebel (USACE), Kurt Dobszinsky, Paul Winchell, David Welch and Debbie Goetz for deployment of receivers, and Jose Reyes-Tomassini for assistance with the AquaTracker program. We also thank Jennifer Scheuerell, Chris Ewing, and Dawn Pucci (HYDRA) and Jose Gimenez and Aswea Porter (POST) for data sharing and management, and Jonathan Thar and Jim Bolger for helping expand the POST project to Puget Sound. NR 69 TC 2 Z9 2 U1 8 U2 47 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0378-1909 EI 1573-5133 J9 ENVIRON BIOL FISH JI Environ. Biol. Fishes PD JAN PY 2015 VL 98 IS 1 BP 357 EP 375 DI 10.1007/s10641-014-0266-3 PG 19 WC Ecology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA AU5CS UT WOS:000345625400031 ER PT J AU Videen, G Kocifaj, M Sun, WB Kai, K Kawamoto, K Horvath, H Mishchenko, M AF Videen, Gorden Kocifaj, Miroslav Sun, Wenbo Kai, Kenji Kawamoto, Kazuaki Horvath, Helmuth Mishchenko, Michael TI Topical issue on optical particle characterization and remote sensing of the atmosphere: Part I SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Editorial Material C1 [Videen, Gorden] US Army Res Lab, Adelphi, MD 20783 USA. [Kocifaj, Miroslav] Slovak Acad Sci, Bratislava 84503, Slovakia. [Sun, Wenbo] Sci Syst & Applicat Inc, Hampton, VA 23666 USA. [Kai, Kenji] Nagoya Univ, Chikusa Ku, Nagoya, Aichi 4648601, Japan. [Kawamoto, Kazuaki] Nagasaki Univ, Fac Environm Studies, Nagasaki, Japan. [Horvath, Helmuth] Univ Vienna, Dept Phys, A-1090 Vienna, Austria. [Mishchenko, Michael] NASA, Goddard Inst Space Studies, New York, NY 10025 USA. RP Videen, G (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM Gorden.w.videen.civ@mail.mil; kocifaj@savba.sk; wenbo.sun-1@nasa.gov; kai@info.human.nagoya-u.ac.jp; kazukawa@nagasaki-u.ac.jp; Horvath5@login.univie.ac.at; michael.i.mishchenko@nasa.gov RI Mishchenko, Michael/D-4426-2012 NR 16 TC 2 Z9 2 U1 1 U2 11 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 EI 1879-1352 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD JAN PY 2015 VL 150 SI SI BP 1 EP 2 DI 10.1016/j.jqsrt.2014.09.008 PG 2 WC Optics; Spectroscopy SC Optics; Spectroscopy GA AU8AQ UT WOS:000345819600001 ER PT J AU Pan, YL AF Pan, Yong-Le TI Detection and characterization of biological and other organic-carbon aerosol particles in atmosphere using fluorescence SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article ID LASER-INDUCED FLUORESCENCE; MULTIPHOTON-EXCITED FLUORESCENCE; CROSS-SECTIONS; POTENTIAL INTERFERENCES; INTRINSIC FLUORESCENCE; EXCITATION WAVELENGTHS; UV FLUORESCENCE; SERUM-ALBUMIN; FUNGAL SPORES; BIOAEROSOLS AB This paper offers a brief review on the detection and characterization of biological and other organic-carbon (OC) aerosol particles in atmosphere using laser-induced-fluorescence (LIF) signatures, It focuses on single individual particles or aggregates in the micron and supermicron size range when they are successively drawn through the interrogation volume of a point detection system. Related technologies for these systems that have been developed in last two decades are also discussed. These results should provide a complementary view for studying atmospheric aerosol particles, particularly bioaerosol and OC aerosol particles from other analytical technologies. Published by Elsevier Ltd. C1 US Army Res Lab, Adelphi, MD 20783 USA. RP Pan, YL (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM yongle.pan.civ@mail.mil FU U.S. Army Research Laboratory mission funds FX Thank for the U.S. Army Research Laboratory mission funds. Thank Carol Johnson and Water Bailey for assisting editing this article. NR 105 TC 15 Z9 15 U1 1 U2 57 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 EI 1879-1352 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD JAN PY 2015 VL 150 SI SI BP 12 EP 35 DI 10.1016/j.jqsrt.2014.06.007 PG 24 WC Optics; Spectroscopy SC Optics; Spectroscopy GA AU8AQ UT WOS:000345819600003 ER PT J AU Zubko, E Shkuratov, Y Videen, G AF Zubko, Evgenij Shkuratov, Yuriy Videen, Gorden TI Effect of morphology on light scattering by agglomerates SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article DE Light scattering; Discrete dipole approximation; Agglomerate particles ID DISCRETE-DIPOLE APPROXIMATION; INTERSTELLAR GRAINS; OPTICAL-CONSTANTS; AEROSOL-PARTICLES; DUST; RADAR; MATRICES AB Using the discrete dipole approximation (DDA), we compute light scattering from irregularly shaped particles with three different types of agglomerate morphologies. The packing density of materials in the model particles spans the range from 0.169 through 0.336. We investigate four different refractive indices m=1.313 + 0i, 1.6+0.0005i, 1.5+0.1i, and 1.855+0.45i, which are representative of various cosmic and terrestrial materials in the visible. In each case, we consider a wide range of size parameters that makes it possible to average the light-scattering response over particle size with a power-law size distribution. We find that despite noticeable differences in particle morphology, their light-scattering responses are remarkably similar; the difference in light scattering often does not exceed the error bars occurring in laboratory measurements of micronsized particles. On the contrary, the impact of refractive index and size distribution on light scattering appears to be much stronger compared with the morphology of complex, agglomerate particles. This finding may simplify considerably the interpretation of photo-polarimetric observations of atmospheric aerosols, cosmic dust particles, etc., because the precise specification of target-particle shape is unnecessary for the analysis. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Zubko, Evgenij; Shkuratov, Yuriy] Kharkov Natl Univ, Inst Astron, UA-61022 Kharkov, Ukraine. [Videen, Gorden] US Army Res Lab, Adelphi, MD 20783 USA. [Videen, Gorden] Space Sci Inst, Boulder, CO 80301 USA. RP Zubko, E (reprint author), Kharkov Natl Univ, Inst Astron, 35 Sumskaya St, UA-61022 Kharkov, Ukraine. EM evgenij.s.zubko@gmail.com FU NASA Lunar Advanced Science and Exploration Research Program [NNX11AB25G]; NASA Outer Planets Research Program [NNX10AP93G] FX This work was partially supported by NASA Lunar Advanced Science and Exploration Research Program (Contract NNX11AB25G) and NASA Outer Planets Research Program (Contract NNX10AP93G). We thank two anonymous referees for their constructive reviews. NR 28 TC 4 Z9 4 U1 0 U2 18 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 EI 1879-1352 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD JAN PY 2015 VL 150 SI SI BP 42 EP 54 DI 10.1016/j.jqsrt.2014.06.023 PG 13 WC Optics; Spectroscopy SC Optics; Spectroscopy GA AU8AQ UT WOS:000345819600005 ER PT J AU Videen, G Zubko, E Sun, WB Shkuratov, Y Yuffa, A AF Videen, Gorden Zubko, Evgenij Sun, Wenbo Shkuratov, Yuriy Yuffa, Alex TI Mixing rules and morphology dependence of the scatterer SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article DE Bruggeman; Mixing rules; Morphology; Agglomerate; Agglomerated debris; Light scattering ID EFFECTIVE-MEDIUM APPROXIMATIONS; DISCRETE-DIPOLE APPROXIMATION; OPTICAL-PROPERTIES; COMETARY DUST; LIGHT-SCATTERING; SPHERICAL INCLUSIONS; COMPOSITE SPHERE; SOLAR-RADIATION; BLACK CARBON; PARTICLES AB We use the discrete dipole algorithm (DDA) to calculate the light-scattering properties from arbitrarily shaped, heterogeneous agglomerated debris particles to study the performance of effective medium approximations. The homogenization of the material properties of the particle has little effect on the orientation-averaged intensity phase function. However, there are some differences in the polarization response. While the structure of the linear-polarization response is not significantly different between the homogeneous and heterogeneous cases, the amplitude of the polarization tends to show a dependence on particle heterogeneity. The Bruggeman mixing rule tends to reproduce the heterogeneous results marginally better than using the average of two distributions of the individual homogeneous components. In addition to the irregularly shaped particles, we also calculated scattering properties of equivalent-volume, homogeneous spheres. As expected, the errors due to assuming homogeneous particles are overwhelmed by those introduced by assuming the irregularly shaped particle may be replaced by an equivalent spherical particle. Published by Elsevier Ltd. C1 [Videen, Gorden; Yuffa, Alex] Army Res Lab, Adelphi, MD 20783 USA. [Videen, Gorden] Space Sci Inst, Boulder, CO 80301 USA. [Zubko, Evgenij; Shkuratov, Yuriy] Kharkov Natl Univ, Inst Astron, UA-61022 Kharkov, Ukraine. [Sun, Wenbo] Sci Syst & Applicat Inc, Hampton, VA 23666 USA. RP Videen, G (reprint author), Army Res Lab, Adelphi, MD 20783 USA. EM gorden.w.videen.civ@mail.mil RI Richards, Amber/K-8203-2015; Yuffa, Alex/B-5498-2014 OI Yuffa, Alex/0000-0002-3600-1131 FU NASA Glory fund [09-GLORY09-0027]; NASA CLARREO mission FX This work was supported by NASA Glory fund 09-GLORY09-0027. Wenbo Sun also was supported by NASA CLARREO mission and he thanks Bruce A. Wielicld and Rosemary R. Baize for this support. NR 45 TC 3 Z9 3 U1 0 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 EI 1879-1352 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD JAN PY 2015 VL 150 SI SI BP 68 EP 75 DI 10.1016/j.jqsrt.2014.07.022 PG 8 WC Optics; Spectroscopy SC Optics; Spectroscopy GA AU8AQ UT WOS:000345819600007 ER PT J AU Videen, G Muinonen, K AF Videen, Gorden Muinonen, Karri TI Light-scattering evolution from particles to regolith SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article DE Light scattering; Agglomerate; Polarization; Coherent backscattering; Radiative transfer; Opposition effect ID COMETARY DUST; COHERENT BACKSCATTERING; PARTICULATE SURFACES; SPHERICAL-PARTICLES; AGGREGATE PARTICLES; NUMERICAL-SOLUTION; PHASE ANGLES; RANDOM-MEDIA; POLARIZATION; MATRIX AB The radiative-transfer coherent-backscattering (RT-CB) model is unique among light-scattering methodologies as it can be used to calculate accurate light-scattering properties of sparsely populated particle volumes with sizes ranging from subwavelength to infinity. We use the RT-CB model to examine the evolution of light-scattering properties as a volume of particles increases from wavelength-sized to several hundreds of wavelengths. We examine the evolution of light-scattering intensity phase function and polarization, as well as linear and circular polarization ratios. We confirm the expected trends for backscattering features to shift to smaller phase angles as the volume increases. In addition, we also see the amplitude of these features increases to some maximum for volumes having size parameters kR similar to 100, before decaying to less than half this amplitude as their volumes approach infinity. Published by Elsevier Ltd. C1 [Videen, Gorden] Army Res Lab, Adelphi, MD 20783 USA. [Videen, Gorden] Space Sci Inst, Boulder, CO 80301 USA. [Muinonen, Karri] Univ Helsinki, Dept Phys, FI-00014 Helsinki, Finland. [Muinonen, Karri] Finnish Geodet Inst, FI-02431 Masala, Finland. RP Videen, G (reprint author), Army Res Lab, Adelphi, MD 20783 USA. EM gorden.w.videen.civ@mail.mil FU ERC Advanced Grant [320773]; Academy of Finland [257966]; NASA Outer Planets Research Program [NNX10AP93G]; NASA Lunar Advanced Science and Exploration Research Program [NNX11AB25G] FX Research funded, in part, by the ERC Advanced Grant no. 320773 entitled "Scattering and Absorption of Electromagnetic Waves in Particulate Media" (SAEMPL), the Academy of Finland (Contract 257966), NASA Outer Planets Research Program (Contract NNX10AP93G), and NASA Lunar Advanced Science and Exploration Research Program (Contract NNX11AB25G). NR 46 TC 5 Z9 5 U1 1 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 EI 1879-1352 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD JAN PY 2015 VL 150 SI SI BP 87 EP 94 DI 10.1016/j.jqsrt.2014.05.019 PG 8 WC Optics; Spectroscopy SC Optics; Spectroscopy GA AU8AQ UT WOS:000345819600009 ER PT J AU Kocifaj, M Videen, G Klacka, J AF Kocifaj, Miroslav Videen, Gorden Klacka, Jozef TI Backscatter in a cloudy atmosphere as a lightning-threat indicator SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article DE Charged water droplets; Water clouds; Electromagnetic scattering; Remote sensing; Radar backscatter ID ELECTROMAGNETIC-WAVES; CHARGED SPHERES; SCATTERING; CONSEQUENCES; DUST AB We present a remote-sensing method for identifying electrically charged droplets in clouds. Our methodology utilizes the electromagnetic (EM) radiation backscattered by the cloud at multiple wavelengths. In general, the backscatter from collections of charged and neutral particles differs in Rayleigh regime. While a uniformly charged sphere can resonate with an incident EM radiation depending on electrostatic potential at the particle surface, the scatter by a neutral particle is governed by the Lorenz-Mie theory, thus resulting in different surface excitations. The effects of electric charges and other microphysical parameters on the electromagnetic interactions with particles are not easily separable. Because the spectral profile of the dielectric function for liquid water (or alternatively icy grains) is known, retrieval of net charges are possible based on the optical behavior of the backscattered EM signals. Such information can be used to determine charge build-up in the atmosphere, which is a condition for lightning. A basic configuration of a measuring system for lightning threats is discussed and described schematically. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Kocifaj, Miroslav] Slovak Acad Sci, ICA, Bratislava 84503, Slovakia. [Kocifaj, Miroslav; Klacka, Jozef] Comenius Univ, Fac Math Phys & Informat, Bratislava 84248, Slovakia. [Videen, Gorden] US Army, Res Lab, AMSRD ARL CI ES, Adelphi, MD 20783 USA. RP Kocifaj, M (reprint author), Slovak Acad Sci, ICA, Dubravska Rd 9, Bratislava 84503, Slovakia. EM kocifaj@savba.sk FU Scientific Grant Agency VEGA [2/0002/12]; Slovak Research and Development Agency [APVV-0177-10] FX This work was partially supported by the Scientific Grant Agency VEGA, Grant no. 2/0002/12 and by the Slovak Research and Development Agency under Contract no: APVV-0177-10. NR 25 TC 5 Z9 5 U1 2 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 EI 1879-1352 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD JAN PY 2015 VL 150 SI SI BP 175 EP 180 DI 10.1016/j.jqsrt.2014.03.004 PG 6 WC Optics; Spectroscopy SC Optics; Spectroscopy GA AU8AQ UT WOS:000345819600017 ER PT J AU McWilliams, B Yu, J Zavaliangos, A AF McWilliams, Brandon Yu, Jian Zavaliangos, Antonios TI Fully coupled thermal-electric-sintering simulation of electric field assisted sintering of net-shape compacts SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID TEMPERATURE DISTRIBUTION; SPARK; POWDER; DISTRIBUTIONS; COMPOSITES; COMPONENTS; TUNGSTEN; STRESS; MODEL AB A fully coupled thermal-electric-sintering finite element model was developed and implemented to predict heterogeneous densification in net-shape compacts using electric field assisted sintering techniques (FAST). FAST is a single-step processing operation for producing bulk materials from powders, in which the powder is heated by the application of electric current under pressure. Previous modeling efforts on FAST have mostly considered the thermal-electric aspect of the problem and have largely neglected the sintering aspect of the problem. A new model was developed by integrating a phenomenological sintering model into a previously established thermal-electric finite element framework to predict the densification kinetics of the sample. The model was used to quantify the effect of specimen geometry on the evolution of thermoelectric gradients and resulting heterogeneous sintering kinetics during FAST processing of a conductive powder. It is shown that the new model which considers sintering kinetics and density-dependent properties provides a substantial increase in accuracy compared to thermal- electric only models. It is also shown that small changes in local resistance due to densification can greatly impact the distribution of thermoelectric gradients during the process, which are exacerbated by heterogeneous stress states induced by sample geometry. Experimental characterization of sintered specimens is used to provide qualitative validation of the model predictions. C1 [McWilliams, Brandon; Yu, Jian] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, Aberdeen Proving Ground, MD 21005 USA. [Zavaliangos, Antonios] Drexel Univ, Dept Mat Sci & Engn, Philadelphia, PA 19104 USA. RP McWilliams, B (reprint author), US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, Aberdeen Proving Ground, MD 21005 USA. EM brandon.a.mcwilliams.civ@mail.mil; jian.h.yu.civ@mail.mil; azavalia@coe.drexel.edu NR 32 TC 5 Z9 5 U1 5 U2 34 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 EI 1573-4803 J9 J MATER SCI JI J. Mater. Sci. PD JAN PY 2015 VL 50 IS 2 BP 519 EP 530 DI 10.1007/s10853-014-8463-1 PG 12 WC Materials Science, Multidisciplinary SC Materials Science GA AU1WJ UT WOS:000345407900002 ER PT J AU Weingarten, NS Byrd, EFC AF Weingarten, N. Scott Byrd, Edward F. C. TI Special quasirandom structures of alon SO COMPUTATIONAL MATERIALS SCIENCE LA English DT Article DE Aluminum oxynitride; Special quasirandom structures; Density functional theory; Elastic constants ID GENERALIZED GRADIENT APPROXIMATION; INITIO MOLECULAR-DYNAMICS; TOTAL-ENERGY CALCULATIONS; AUGMENTED-WAVE METHOD; N-O SYSTEM; ALUMINUM OXYNITRIDE; ELECTRONIC-PROPERTIES; ALN-AL2O3 SECTION; BASIS-SET; SPINEL AB The crystal structure of Al23O27N5, which is an ideal stoichiometry of aluminum oxynitride (or alon), is a defect spinel in which a vacancy is present in the unit cell. Despite the lattice positions being fixed, the location of the vacancy and the positions of the five nitrogen atoms are not unique, presenting a challenge to the prediction of the crystal structure. This problem is analogous to random alloys, for which a technique has been developed to identify small scale simulation cells called special quasirandom structures (SQS). We present SQS for alon, and discuss the unique features of these structures for this material. We also modified the SQS methodology to identify the first cubic crystal structure for alon with the above stoichiometry. Published by Elsevier B.V. C1 [Weingarten, N. Scott; Byrd, Edward F. C.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Weingarten, NS (reprint author), US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM neil.s.weingarten.civ@mail.mil NR 31 TC 3 Z9 3 U1 1 U2 29 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0927-0256 EI 1879-0801 J9 COMP MATER SCI JI Comput. Mater. Sci. PD JAN PY 2015 VL 96 BP 312 EP 318 DI 10.1016/j.commatsci.2014.09.021 PN A PG 7 WC Materials Science, Multidisciplinary SC Materials Science GA AT4XU UT WOS:000344946600045 ER PT J AU Bruhl, JC Varma, AH Johnson, WH AF Bruhl, Jakob C. Varma, Amit H. Johnson, William H. TI Design of composite SC walls to prevent perforation from missile impact SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Projectile impact; Composite structure; Concrete; Steel plate ID AIRCRAFT ENGINE MISSILES; SPHERICAL-NOSE RODS; REINFORCED-CONCRETE; SHEAR CONNECTORS; LOCAL DAMAGE; PROJECTILES; PENETRATION; TARGETS; PLATES AB This paper presents a three-step method for designing steel plate composite (SC) walls subjected to missile impact. This method can be used to compute the minimum required steel plate thickness for SC walls to prevent perforation due to missile impact. The design method was verified using the complete experimental database of 130 SC wall missile impact tests compiled as part of this research. The design method compares favorably with the observations and results from the experimental database and can be used within its range of applicability to design SC walls to prevent missile perforation. The paper also presents the development and benchmarking of 3D finite element models for predicting the behavior and local failure of SC walls subjected to missile impact. The models were benchmarked using test results from the experimental database and results were used to confirm the failure mechanism of SC walls subjected to missile impact. The benchmarked models were used to conduct analytical parametric studies to expand the database, and further verify the design method. The numerical modeling approach is recommended for future research and design of specific SC wall configurations to resist design basis missiles. Published by Elsevier Ltd. C1 [Bruhl, Jakob C.] US Army, W Lafayette, IN 47907 USA. [Bruhl, Jakob C.; Varma, Amit H.] Purdue Univ, Sch Civil Engn, W Lafayette, IN 47907 USA. [Johnson, William H.] Bechtel Corp, Frederick, MD 21703 USA. RP Bruhl, JC (reprint author), US Army, 550 Stadium Mall Dr, W Lafayette, IN 47907 USA. EM jbruhl@purdue.edu; ahvarma@purdue.edu; whjohnson@bechtel.com OI Bruhl, Jakob/0000-0002-1645-4520; Varma, Amit/0000-0001-7153-4681 NR 33 TC 18 Z9 18 U1 0 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X EI 1879-3509 J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD JAN PY 2015 VL 75 BP 75 EP 87 DI 10.1016/j.ijimpeng.2014.07.015 PG 13 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA AT7JB UT WOS:000345111200008 ER PT J AU Feng, YZ Siegmund, T Habtour, E Riddick, J AF Feng, Yuezhong Siegmund, Thomas Habtour, Ed Riddick, Jaret TI Impact mechanics of topologically interlocked material assemblies SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Topologically interlocking material assemblies; Impact loading; Ballistic limit; Residual velocity; Modeling and simulation ID MATERIAL-PROPERTY SPACE; ENERGY-ABSORPTION; BALLISTIC IMPACT; DYNAMIC FRAGMENTATION; COMPOSITE-MATERIALS; HYBRID MATERIALS; SHAPED ELEMENTS; STEEL PLATES; PENETRATION; PRINCIPLE AB The objective of the present study is to provide understanding of potential energy absorption and dissipation mechanisms and benefits of topologically interlocked material (TIM) assemblies under impact loading. The study is motivated by earlier findings that TIMs under low rate loading demonstrated attractive properties including the capability to arrest and localize cracks and to exhibit a quasi-ductile response even when the unit elements are made of brittle materials. It is hypothesized that TIMs due to their modularity would possess advantageous impact characteristics. In order to test this hypothesis, a series of computational experiments on the dynamic loading of TIMs are conducted. Results obtained in this study are presented for a planar TIM configuration based on a dense packing of tetrahedral unit elements to form an energy absorption layer. Finite element models are calibrated on samples fabricated using fused deposition modeling (FDM) additive manufacturing (AM). With employing the Lambert-Jonas formula to interpret the numerical data, it is demonstrated that TIMs can absorb more impact energy than conventional solid plates. An extended Lambert-Jonas model is defined such that accurate description of the impact response of TIMs is obtained. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Feng, Yuezhong; Siegmund, Thomas] Purdue Univ, Sch Mech Engn, W Lafayette, IN 47907 USA. [Habtour, Ed; Riddick, Jaret] US Army Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Siegmund, T (reprint author), Purdue Univ, Sch Mech Engn, W Lafayette, IN 47907 USA. EM siegmund@purdue.edu OI Habtour, Ed/0000-0002-9083-9285; Siegmund, Thomas/0000-0001-8162-9609 FU Army Research Office grant Mechanics of Multiscale Energy Dissipation (ARO) [W911 NF-12-1-0370]; National Science Foundation (N.S.F.) FX The authors Y. Feng and T. Siegmund acknowledge funding by the Army Research Office grant Mechanics of Multiscale Energy Dissipation (ARO Grant No. W911 NF-12-1-0370) in Topologically Interlocked Materials-11.1 STIR, (Larry Russell Jr, Solid Mechanics, Program Manager). T. Siegmund also acknowledges support from the National Science Foundation (N.S.F.) while working at N.S.F. NR 44 TC 9 Z9 9 U1 2 U2 27 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X EI 1879-3509 J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD JAN PY 2015 VL 75 BP 140 EP 149 DI 10.1016/j.ijimpeng.2014.08.003 PG 10 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA AT7JB UT WOS:000345111200013 ER PT J AU Thiagarajan, G Kadambi, AV Robert, S Johnson, CF AF Thiagarajan, Ganesh Kadambi, Anirudha V. Robert, Stephen Johnson, Carol F. TI Experimental and finite element analysis of doubly reinforced concrete slabs subjected to blast loads SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Blast loading; Reinforced concrete slab; Experimental data; Finite element simulation; High strength materials ID NUMERICAL-SIMULATION; MATERIAL MODEL; PERFORATION AB This paper presents research on the response and behavior of both high strength concrete (107 MPa) and normal strength concrete (27.6 MPa) slabs doubly reinforced with high strength low alloy vanadium (HSLA-V) reinforcement (VR) and conventional steel reinforcing bars (NR) subjected to explosive loads. Four types of reinforced concrete (RC) slabs namely High Strength Concrete (HSC) with HSLA-V Steel Reinforcing bars (HSC-VR), High Strength Concrete with Conventional Steel Reinforcing bars (HSC-NR), Normal Strength Concrete (NSC) with HSLA-V Steel Reinforcing bars (NSC-VR), and Normal Strength Concrete with Conventional Steel Reinforcing bars (NSC-NR) have been studied and compared both experimentally and numerically. The slabs were subjected to blast loads using a shock tube capable of generating both positive and negative phase pressures. Data collected during the dynamic experiments consisted of reflected pressure obtained from several pressure gages arranged along the perimeter of the test article and mid-span deflections captured from an accelerometer, a laser device, and high speed video. The numerical analysis was performed with the commercial program LS-DYNA using two material models. The concrete material models considered were Winfrith Concrete Model (WCM) and Concrete Damage Model Release 3 (CDMR3). Results from the numerical simulation are compared with the experimental values to determine material parameters and other finite element model related constraints. Mesh sensitivity and crack propagation studies were also conducted. From this study it was observed that CDMR3 and WCM can be used over a wider range of concrete compressive strengths. The advantages and disadvantages of using high strength materials are discussed. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Thiagarajan, Ganesh; Kadambi, Anirudha V.] Univ Missouri, Dept Civil Engn, Kansas City, MO 64110 USA. [Robert, Stephen; Johnson, Carol F.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Thiagarajan, G (reprint author), Univ Missouri, Dept Civil Engn, 352 Flarsheim Hall,5100 Rockhill Rd, Kansas City, MO 64110 USA. EM ganesht@umkc.edu NR 34 TC 12 Z9 14 U1 7 U2 33 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X EI 1879-3509 J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD JAN PY 2015 VL 75 BP 162 EP 173 DI 10.1016/j.ijimpeng.2014.07.018 PG 12 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA AT7JB UT WOS:000345111200015 ER PT J AU Nilakantan, G Merrill, RL Keefe, M Gillespie, JW Wetzel, ED AF Nilakantan, Gaurav Merrill, Richard L. Keefe, Michael Gillespie, John W., Jr. Wetzel, Eric D. TI Experimental investigation of the role of frictional yarn pull-out and windowing on the probabilistic impact response of kevlar fabrics SO COMPOSITES PART B-ENGINEERING LA English DT Article DE Aramid fiber; Fabrics/textiles; Impact behavior; Statistical properties/methods ID BALLISTIC IMPACT; ENERGY-ABSORPTION; WOVEN FABRICS; STRENGTH; PERFORMANCE; BEHAVIOR; SINGLE AB The probabilistic impact responses of single layer greige and scoured plain-weave Kevlar KM2 fabrics are experimentally studied. Single-layer, 101 cm x 101 cm fabric targets are mounted in a novel equilateral octagon (EO) fixture that leaves the principal yarns unclamped. A probabilistic velocity response (PVR) curve, which describes the probability of fabric penetration as a function of projectile impact velocity, is generated through a series of thirty impact tests using a spherical steel projectile impacted at velocities between 69 and 113 m/s. Additional experiments are conducted by impacting targets repeatedly at identical velocities, and comparing the resulting residual velocities of the penetrating projectiles. Fabric penetration in all cases is entirely accommodated by yarn pull-out and windowing, without any principal yarn failure at the impact site. The results indicate that frictional yarn sliding and pull-out are the primary energy dissipating mechanisms during these impact conditions. Controlled yarn pull-out experiments are conducted on the same greige and scoured fabrics to statistically characterize the yarn pull-out loads. Variability in pull-out forces in the greige fabrics are measurably higher than the variability in pull-out forces for the scoured fabrics, which correlates well with variability trends in the PVR and residual velocity ballistic experiments. Additional factors, such as yarn-projectile friction and differences in filament packing efficiency, are hypothesized to also contribute to the observed differences in the greige and scoured fabric impact responses. Published by Elsevier Ltd. C1 [Nilakantan, Gaurav] Univ So Calif, Dept Chem Engn & Mat Sci, MC Gill Composites Ctr, Los Angeles, CA 90089 USA. [Merrill, Richard L.; Wetzel, Eric D.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Keefe, Michael] Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. [Nilakantan, Gaurav; Gillespie, John W., Jr.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. RP Wetzel, ED (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM eric.d.wetzel2.civ@mail.mil FU Army Research Laboratory FX The authors would like to acknowledge Kyle Slusarski (ARL) for assistance with optical microscopy. This research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-06-2-0011. The views and conclusions contained in this document are those of the authors and should not be interested as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 23 TC 5 Z9 6 U1 3 U2 27 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-8368 EI 1879-1069 J9 COMPOS PART B-ENG JI Compos. Pt. B-Eng. PD JAN PY 2015 VL 68 BP 215 EP 229 DI 10.1016/j.compositesb.2014.08.033 PG 15 WC Engineering, Multidisciplinary; Materials Science, Composites SC Engineering; Materials Science GA AT3GK UT WOS:000344823700025 ER PT J AU Russell, K Reinhardt, L Lee, WT AF Russell, Kevin Reinhardt, Lyonel Lee, Wen-Tzong TI AN EVALUATION OF PRIMER PRESEATING IN SMALL CALIBER CARTRIDGE PRODUCTION SO MECHANICS BASED DESIGN OF STRUCTURES AND MACHINES LA English DT Article DE Cartridge case; Primer seating; Small caliber ammunition production; Stamping process AB This work presents the findings of a study to quantify the relative effectiveness of the primer preseating operation in small caliber cartridge production. In theory, primer preseating would enable cartridge stamping tools to achieve deeper stamping penetration depths and subsequently, greater primer retention forces. This is because, with preseating incorporated in the existing small caliber cartridge production process, a cartridge stamping tool would be fully dedicated to performing the case stamping operation (rather than the simultaneous primer seating and case stamping operations it currently performs). The findings presented in this work include measured percentages of total stamping tool force dedicated to primer seating, stamping tool penetration depths with and without primer preseating and primer retention forces with and without primer preseating. These findings and their underlying principles were produced through a static force equilibrium analysis and finite element modeling and simulation studies. C1 [Russell, Kevin] New Jersey Inst Technol, Dept Mech & Ind Engn, Newark, NJ 07102 USA. [Reinhardt, Lyonel] US Army Res, Armaments Engn & Technol Ctr, Ctr Dev & Engn, Picatinny Arsenal, NJ USA. [Lee, Wen-Tzong] Natl Pingtung Univ Sci & Technol, Dept Biomechatron Engn, Neipu, Pingtung, Taiwan. RP Russell, K (reprint author), New Jersey Inst Technol, Dept Mech & Ind Engn, Newark, NJ 07102 USA. EM kevin.russell@njit.edu NR 11 TC 0 Z9 0 U1 2 U2 4 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1539-7734 EI 1539-7742 J9 MECH BASED DES STRUC JI Mech. Based Des. Struct. Mech. PY 2015 VL 43 IS 1 BP 112 EP 123 DI 10.1080/15397734.2014.908725 PG 12 WC Mechanics SC Mechanics GA AP8FN UT WOS:000342314300007 ER PT J AU Jokanovic, B Amin, M Dogaru, T AF Jokanovic, Branka Amin, Moeness Dogaru, Traian TI Time-Frequency Signal Representations Using Interpolations in Joint-Variable Domains SO IEEE GEOSCIENCE AND REMOTE SENSING LETTERS LA English DT Article DE Ambiguity domain; cross-terms reduction; interpolation; micro Doppler; radar; time-frequency distribution (TFD) ID TARGET DETECTION; DECOMPOSITION; DISTRIBUTIONS; KERNELS AB Time-frequency (TF) representations are a powerful tool for analyzing Doppler and micro-Doppler signals. These signals are frequently encountered in various radar applications. Data interpolators play a unique role in TF signal representations under missing samples. When applied in the instantaneous autocorrelation domain over the time variable, the low-pass filter characteristic underlying linear interpolators lends itself to cross-terms reduction in the ambiguity domain. This is in contrast to interpolation performed over the lag variable or a direct interpolation of the raw data. We demonstrate the interpolator performance in both the time domain and the time-lag domain and compare it with sparse signal reconstruction, which exploits the local sparsity property assumed by most Doppler radar signals. C1 [Jokanovic, Branka; Amin, Moeness] Villanova Univ, Ctr Adv Commun, Villanova, PA 19085 USA. [Dogaru, Traian] US Army Res Lab, Adelphi, MD 20783 USA. RP Jokanovic, B (reprint author), Villanova Univ, Ctr Adv Commun, Villanova, PA 19085 USA. EM branka.jokanovic@villanova.edu FU U.S. Army Research Office/Army Research Laboratory [W911NF-11-1-0536] FX This work was supported by the U.S. Army Research Office/Army Research Laboratory under Contract W911NF-11-1-0536. NR 26 TC 2 Z9 2 U1 0 U2 11 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1545-598X EI 1558-0571 J9 IEEE GEOSCI REMOTE S JI IEEE Geosci. Remote Sens. Lett. PD JAN PY 2015 VL 12 IS 1 BP 204 EP 208 DI 10.1109/LGRS.2014.2332162 PG 5 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA AN9TU UT WOS:000340952500042 ER PT J AU Hartzell, PJ Glennie, CL Finnegan, DC AF Hartzell, Preston J. Glennie, Craig L. Finnegan, David C. TI Empirical Waveform Decomposition and Radiometric Calibration of a Terrestrial Full-Waveform Laser Scanner SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE Calibration; full waveform; Light Detection And Ranging (LiDAR); reflectance; remote sensing ID INTENSITY DATA; LIDAR DATA; CLASSIFICATION; DISCRIMINATION AB The parametric models used in Light Detection And Ranging (LiDAR) waveform decomposition routines are inherently estimates of the sensor's system response to backscattered laser pulse power. This estimation can be improved with an empirical system response model, yielding reduced waveform decomposition residuals and more precise echo ranging. We develop an empirical system response model for a Riegl VZ-400 terrestrial laser scanner, from a series of observations to calibrated reflectance targets, and present a numerical least squaresmethod for decomposing waveforms with the model. The target observations are also used to create an empirical radiometric calibration model that accommodates a nonlinear relationship between received optical power and echo peak amplitude, and to examine the temporal stability of the instrument. We find that the least squares waveform decomposition based on the empirical system response model decreases decomposition fitting errors by an order of magnitude for high-amplitude returns and reduces range estimation errors on planar surfaces by 17% over a Gaussian model. The empirical radiometric calibration produces reflectance values self-consistent to within 5% for several materials observed at multiple ranges, and analysis of multiple calibration data sets collected over a one-year period indicates that echo peak amplitude values are stable to within +/- 3% for target ranges up to 125 m. C1 [Hartzell, Preston J.; Glennie, Craig L.] Univ Houston, Dept Civil & Environm Engn, Houston, TX 77204 USA. [Finnegan, David C.] US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Hartzell, PJ (reprint author), Univ Houston, Dept Civil & Environm Engn, Houston, TX 77204 USA. EM pjhartzell@uh.edu; clglennie@uh.edu; david.finnegan@usace.army.mil FU U.S. Department of Energy; CRREL FX The work of P. J. Hartzell was supported through an appointment to the Student Research Participation Program at the U.S. Army Cold Regions Research and Engineering Laboratory (CRREL) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and CRREL. NR 30 TC 6 Z9 6 U1 5 U2 38 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0196-2892 EI 1558-0644 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD JAN PY 2015 VL 53 IS 1 BP 162 EP 172 DI 10.1109/TGRS.2014.2320134 PG 11 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA AO7MG UT WOS:000341536700013 ER PT J AU Ramirez, A Arce, GR Sadler, BM AF Ramirez, Ana Arce, Gonzalo R. Sadler, Brian M. TI Spectral Image Unmixing From Optimal Coded-Aperture Compressive Measurements SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE Coded aperture; coded-aperture snapshot spectral imaging system (CASSI); hyperspectral imagery; sparsity; spectral unmixing ID DESIGN AB Hyperspectral remote sensing often captures imagery where the spectral profiles of the spatial pixels are the result of the reflectance contribution of numerous materials. Spectral unmixing is then used to extract the collection of materials, or endmembers, contained in the measured spectra and a set of corresponding fractions that indicate the abundance of each material present at each pixel. This paper aims at developing a spectral unmixing algorithm directly from compressive measurements acquired using the coded-aperture snapshot spectral imaging (CASSI) system. The proposed method first uses the compressive measurements to find a sparse vector representation of each pixel in a 3-D dictionary formed by a 2-D wavelet basis and a known spectral library of endmembers. The sparse vector representation is estimated by solving a sparsity-constrained optimization problem using an algorithm based on the variable splitting augmented Lagrangian multipliers method. The performance of the proposed spectral unmixing method is improved by taking optimal CASSI compressive measurements obtained when optimal coded apertures are used in the optical system. The optimal coded apertures are designed such that the CASSI sensing matrix satisfies a restricted isometry property with high probability. Simulations with synthetic and real hyperspectral cubes illustrate the accuracy of the proposed unmixing method. C1 [Ramirez, Ana] Univ Ind Santander, Dept Elect Engn, Santander 680002, Colombia. [Arce, Gonzalo R.] Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA. [Sadler, Brian M.] US Army Res Lab, Adelphi, MD 20783 USA. RP Ramirez, A (reprint author), Univ Ind Santander, Dept Elect Engn, Santander 680002, Colombia. FU Army Research Laboratory; Army Research Office [W911NF-11-1-0368]; National Science Foundation [CCF-0915800] FX Manuscript received September 15, 2013; revised February 27, 2014; accepted April 29, 2014. This work was supported in part by the Army Research Laboratory and the Army Research Office under Grant W911NF-11-1-0368 and in part by the National Science Foundation under Grant CCF-0915800. NR 27 TC 2 Z9 3 U1 2 U2 29 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0196-2892 EI 1558-0644 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD JAN PY 2015 VL 53 IS 1 BP 405 EP 415 DI 10.1109/TGRS.2014.2322820 PG 11 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA AO7MG UT WOS:000341536700031 ER PT J AU Satapathi, S Gill, HS Li, L Samuelson, L Kumar, J Mosurkal, R AF Satapathi, Soumitra Gill, Hardeep Singh Li, Lian Samuelson, Lynne Kumar, Jayant Mosurkal, Ravi TI Synthesis of nanoparticles of P3HT and PCBM for optimizing morphology in polymeric solar cells SO APPLIED SURFACE SCIENCE LA English DT Article DE Conjugated polymer; Nanoparticles; Morphology; Polymeric solar cells ID BAND-GAP POLYMERS; FORCE MICROSCOPY; PHOTOVOLTAICS; LAYERS AB Nanoparticles (NPs) with opposite charges of a donor polymer, poly(3-hexyl thiophene) (P3HT) and an acceptor molecule, phenyl-C61-butyric acid methyl ester (PCBM) were synthesized using simple miniemulsion technique. The NPs were examined by dynamic light scattering, atomic force microscopy and scanning electron microscopy to confirm the formation of the NPs. The NPs were assembled into thin films by spin-coating of a blend of the NPs dispersion. The built-up of a five layered film was monitored by UV-vis absorption spectroscopy. Our preliminary study demonstrated that a solar cell made from an annealed NP film can exhibit photovoltaic response. (C) 2014 Elsevier B.V. All rights reserved. C1 [Satapathi, Soumitra; Gill, Hardeep Singh; Kumar, Jayant] Univ Massachusetts, Ctr Adv Mat, Lowell, MA 01854 USA. [Satapathi, Soumitra; Gill, Hardeep Singh; Kumar, Jayant] Univ Massachusetts, Dept Phys & Appl Phys, Lowell, MA 01854 USA. [Li, Lian; Samuelson, Lynne; Mosurkal, Ravi] US Army, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Mosurkal, R (reprint author), US Army, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. EM Ravi.Mosurkal.civ@mail.mil RI MOSURKAL, RAVI/P-6981-2015 FU U.S. Army Natick Soldier Research, Development and Engineering Center (NSRDEC); Energy Frontiers Research Centers (EFRC) from U.S. Department of Energy; Center for Advanced Materials at the University of Massachusetts Lowell FX Financial support from U.S. Army Natick Soldier Research, Development and Engineering Center (NSRDEC) and the Energy Frontiers Research Centers (EFRC) from U.S. Department of Energy is gratefully acknowledged. S.S. will like to thank the 2012 Tripathy Summer Graduate Fellowship from the Center for Advanced Materials at the University of Massachusetts Lowell. This research was also supported in part by an appointment to the Faculty Research Participation Program at the U.S. Army NSRDEC administered by the Oak Ridge Institute for Science and Education through an inter-agency agreement between the U.S. Department of Energy and NSRDEC. NR 22 TC 10 Z9 10 U1 1 U2 38 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-4332 EI 1873-5584 J9 APPL SURF SCI JI Appl. Surf. Sci. PD DEC 30 PY 2014 VL 323 BP 13 EP 18 DI 10.1016/j.apsusc.2014.07.175 PG 6 WC Chemistry, Physical; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter SC Chemistry; Materials Science; Physics GA AU3KJ UT WOS:000345511600004 ER PT J AU Zaar, M Fedyk, CG Pidcoke, HF Scherer, MR Ryan, KL Rickards, CA Hinojosa-Laborde, C Convertino, VA Cap, AP AF Zaar, Morten Fedyk, Chriselda G. Pidcoke, Heather F. Scherer, Michael R. Ryan, Kathy L. Rickards, Caroline A. Hinojosa-Laborde, Carmen Convertino, Victor A. Cap, Andrew P. TI Platelet Activation after Presyncope by Lower Body Negative Pressure in Humans SO PLOS ONE LA English DT Article ID COAGULATION SYSTEM; BLOOD; VASOPRESSIN; MECHANISMS; HEMORRHAGE; TOLERANCE; RESPONSES; TRAUMA; STATE; MEN AB Central hypovolemia elevates hemostatic activity which is essential for preventing exsanguination after trauma, but platelet activation to central hypovolemia has not been described. We hypothesized that central hypovolemia induced by lower body negative pressure (LBNP) activates platelets. Eight healthy subjects were exposed to progressive central hypovolemia by LBNP until presyncope. At baseline and 5 min after presyncope, hemostatic activity of venous blood was evaluated by flow cytometry, thrombelastography, and plasma markers of coagulation and fibrinolysis. Cell counts were also determined. Flow cytometry revealed that LBNP increased mean fluorescence intensity of PAC-1 by 1959 +/- 455 units (P< 0.001) and percent of fluorescence-positive platelets by 27 +/- 18%-points (P=0.013). Thrombelastography demonstrated that coagulation was accelerated (R-time decreased by 0.8 +/- 0.4 min (P=0.001)) and that clot lysis increased (LY60 by 6.0 +/- 5.8%-points (P=0.034)). Plasma coagulation factor VIII and von Willebrand factor ristocetin cofactor activity increased (P=0.011 and P=0.024, respectively), demonstrating increased coagulation activity, while von Willebrand factor antigen was unchanged. Plasma protein C activity and tissue-type plasminogen activator increased (P=0.007 and P=0.017, respectively), and D-dimer increased by 0.03 +/- 0.02 mg l(-1) (P=0.031), demonstrating increased fibrinolytic activity. Plasma prothrombin time and activated partial thromboplastin time were unchanged. Platelet count increased by 15 +/- 13% (P=0.014) and red blood cells by 9 +/- 4% (P=0.002). In humans, LBNP-induced presyncope activates platelets, as evidenced by increased exposure of active glycoprotein IIb/IIIa, accelerates coagulation. LBNP activates fibrinolysis, similar to hemorrhage, but does not alter coagulation screening tests, such as prothrombin time and activated partial thromboplastin time. LBNP results in increased platelet counts, but also in hemoconcentration. C1 [Zaar, Morten] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Fedyk, Chriselda G.; Pidcoke, Heather F.; Scherer, Michael R.; Ryan, Kathy L.; Hinojosa-Laborde, Carmen; Convertino, Victor A.; Cap, Andrew P.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Rickards, Caroline A.] Univ N Texas, Hlth Sci Ctr Ft Worth, Ft Worth, TX USA. RP Zaar, M (reprint author), Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. EM zaar@uthscsa.edu FU United States Army, Medical Research and Materiel Command FX This study was funded by the United States Army, Medical Research and Materiel Command. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 31 TC 1 Z9 1 U1 1 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 29 PY 2014 VL 9 IS 12 DI 10.1371/journal.pone.0116174 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AX7UN UT WOS:000347120200104 ER PT J AU Schreiber, JM Omcikus, ZR Eden, TJ Sharma, MM Champagne, V Patankar, SN AF Schreiber, J. M. Omcikus, Z. R. Eden, T. J. Sharma, M. M. Champagne, V. Patankar, S. N. TI Combined effect of hot extrusion and heat treatment on the mechanical behavior of 7055 AA processed via spray metal forming SO JOURNAL OF ALLOYS AND COMPOUNDS LA English DT Article DE Extrusion aluminum alloys ID ALUMINUM-ALLOY; TENSILE PROPERTIES; MICROSTRUCTURE AB The mechanical properties of 7xxx series alloys can be tailored by subjecting them to deformation processing and heat treatment. In the present study dealing with spray forming of 7055 AA, extrusion and heat treatment involving solutionizing followed by peak aging resulted in improved mechanical behavior. The strength and ductility obtained are comparable to that of extruded and heat treated as-cast 7055 AA (Mondal et al., 2011) [1]. Spray forming offers an alternate route to develop high strength aluminum alloys and the current study is an attempt that draws closer to the target value of 1GPa strength and 10% ductility for high strength aluminum alloys. Published by Elsevier B.V. C1 [Schreiber, J. M.; Omcikus, Z. R.; Eden, T. J.; Patankar, S. N.] Penn State Univ, Appl Res Lab, State Coll, PA 16801 USA. [Sharma, M. M.] Bucknell Univ, Dept Mech Engn, Lewisburg, PA 17837 USA. [Champagne, V.] US Army, Res Lab, Washington, DC USA. RP Patankar, SN (reprint author), Penn State Univ, Appl Res Lab, State Coll, PA 16801 USA. EM snp11@psu.edu NR 13 TC 3 Z9 4 U1 8 U2 36 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0925-8388 EI 1873-4669 J9 J ALLOY COMPD JI J. Alloy. Compd. PD DEC 25 PY 2014 VL 617 BP 135 EP 139 DI 10.1016/j.jallcom.2014.07.184 PG 5 WC Chemistry, Physical; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Chemistry; Materials Science; Metallurgy & Metallurgical Engineering GA AS2UX UT WOS:000344135800024 ER PT J AU Challacombe, JF Stubben, CJ Klimko, CP Welkos, SL Kern, SJ Bozue, JA Worsham, PL Cote, CK Wolfe, DN AF Challacombe, Jean F. Stubben, Chris J. Klimko, Christopher P. Welkos, Susan L. Kern, Steven J. Bozue, Joel A. Worsham, Patricia L. Cote, Christopher K. Wolfe, Daniel N. TI Interrogation of the Burkholderia pseudomallei Genome to Address Differential Virulence among Isolates SO PLOS ONE LA English DT Article ID BACILLUS-SUBTILIS; ANTIBIOTIC SUSCEPTIBILITY; NORTHERN AUSTRALIA; CARBON METABOLISM; ACUTE MELIOIDOSIS; CAUSATIVE AGENT; GENE-EXPRESSION; BACTERIA; RPOS; ADAPTATION AB Infection by the Gram-negative pathogen Burkholderia pseudomallei results in the disease melioidosis, acquired from the environment in parts of southeast Asia and northern Australia. Clinical symptoms of melioidosis range from acute (fever, pneumonia, septicemia, and localized infection) to chronic (abscesses in various organs and tissues, most commonly occurring in the lungs, liver, spleen, kidney, prostate and skeletal muscle), and persistent infections in humans are difficult to cure. Understanding the basic biology and genomics of B. pseudomallei is imperative for the development of new vaccines and therapeutic interventions. This formidable task is becoming more tractable due to the increasing number of B. pseudomallei genomes that are being sequenced and compared. Here, we compared three B. pseudomallei genomes, from strains MSHR668, K96243 and 1106a, to identify features that might explain why MSHR668 is more virulent than K96243 and 1106a in a mouse model of B. pseudomallei infection. Our analyses focused on metabolic, virulence and regulatory genes that were present in MSHR668 but absent from both K96243 and 1106a. We also noted features present in K96243 and 1106a but absent from MSHR668, and identified genomic differences that may contribute to variations in virulence noted among the three B. pseudomallei isolates. While this work contributes to our understanding of B. pseudomallei genomics, more detailed experiments are necessary to characterize the relevance of specific genomic features to B. pseudomallei metabolism and virulence. Functional analyses of metabolic networks, virulence and regulation shows promise for examining the effects of B. pseudomallei on host cell metabolism and will lay a foundation for future prediction of the virulence of emerging strains. Continued emphasis in this area will be critical for protection against melioidosis, as a better understanding of what constitutes a fully virulent Burkholderia isolate may provide for better diagnostic and medical countermeasure strategies. C1 [Challacombe, Jean F.; Stubben, Chris J.] Los Alamos Natl Lab, Biosci Div, Los Alamos, NM 87545 USA. [Klimko, Christopher P.; Welkos, Susan L.; Bozue, Joel A.; Worsham, Patricia L.; Cote, Christopher K.] US Army Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD USA. [Kern, Steven J.] US Army Med Res Inst Infect Dis, Div Biostat, Ft Detrick, MD USA. [Wolfe, Daniel N.] Def Threat Reduct Agcy, Chem & Biol Technol Dept, Ft Belvoir, VA USA. RP Challacombe, JF (reprint author), Los Alamos Natl Lab, Biosci Div, Los Alamos, NM 87545 USA. EM jchalla@lanl.gov FU Defense Threat Reduction Agency (CCAR) [CB3846 PPE-1, CBS119924543-7049-BASIC] FX This project was funded by the Defense Threat Reduction Agency (CCAR# CB3846 PPE-1 Burkholderia and CBS119924543-7049-BASIC). The funder had no role in study design, data collection and analysis, or decision to publish the manuscript. DNW contributed to the writing of the manuscript. NR 73 TC 5 Z9 5 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 23 PY 2014 VL 9 IS 12 AR e115951 DI 10.1371/journal.pone.0115951 PG 27 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AZ9UY UT WOS:000348563300091 PM 25536074 ER PT J AU Coulibaly, S Heinzmann, C Beyer, FL Balog, S Weder, C Fiore, GL AF Coulibaly, Souleymane Heinzmann, Christian Beyer, Frederick L. Balog, Sandor Weder, Christoph Fiore, Gina L. TI Supramolecular Polymers with Orthogonal Functionality SO MACROMOLECULES LA English DT Article ID THERMOPLASTIC ELASTOMERS; TRIBLOCK COPOLYMERS; COMPLEXES; CHAIN AB Supramolecular polymers with orthogonal interactions are of broad interest, and reports on such materials with multifunctional stimuli-responsive behavior are rare. Polymer blends based on a poly(ethylene-co-butylene) core (PEB) terminated with either 2-ureido-4[1H]-pyrimidinone (UPy) hydrogen-bonding motifs (UPy-PEB-UPy) or 2,6-bis(1'-methylbenzimidazolyl)pyridine (Mebip) ligands coordinated to metal ions ([M(Mebip-PEB-Mebip)](2+) (M = Zn, Fe)) were prepared. The degree of orthogonality of the supramolecular polymer blends was explored by UVvis spectroscopy, small-angle X-ray scattering, and dynamic mechanical thermal analysis (DMTA). Polymer blends of [Zn(Mebip-PEB-Mebip)](NTf2)(2) and UPy-PEB-UPy resulted in a statistical mixture of noncovalent interactions, whereas blends with [Fe(Mebip-PEB-Mebip)](ClO4)(2) and UPy-PEB-UPy assembled in an orthogonal fashion. Additionally, the DMTA showed two transitions for the disassembly of UPy (ca. 60 degrees C) and Fe2+-Mebip (ca. 180 degrees C) phases. The Fe2+-Mebip interactions were selectively disrupted by the addition of a competitive ligand, demonstrating that each supramolecular motif can be targeted with either a thermal or chemical stimulus. C1 [Coulibaly, Souleymane; Heinzmann, Christian; Balog, Sandor; Weder, Christoph; Fiore, Gina L.] Univ Fribourg, Adolphe Merkle Inst, CH-1700 Fribourg, Switzerland. [Beyer, Frederick L.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Weder, C (reprint author), Univ Fribourg, Adolphe Merkle Inst, Chemin Verdiers 4, CH-1700 Fribourg, Switzerland. EM christoph.weder@unifr.ch; gina.fiore@unifr.ch RI Balog, Sandor/F-3860-2014; OI Balog, Sandor/0000-0002-4847-9845; Merkle Institute, Adolphe/0000-0002-6220-424X FU Swiss National Science Foundation [200021_13540/1, R'equip 206021_128728]; US Army Research Office [W911NF-12-1-0339]; Swiss Commission for Technology and Innovation (CTI) [13746.1]; Adolphe Merkle Foundation FX We acknowledge funding from the Swiss National Science Foundation (200021_13540/1 and R'equip 206021_128728), the US Army Research Office (W911NF-12-1-0339), the Swiss Commission for Technology and Innovation (CTI, Grant No 13746.1), and the Adolphe Merkle Foundation. NR 33 TC 5 Z9 5 U1 5 U2 66 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0024-9297 EI 1520-5835 J9 MACROMOLECULES JI Macromolecules PD DEC 23 PY 2014 VL 47 IS 24 BP 8487 EP 8496 DI 10.1021/ma501492u PG 10 WC Polymer Science SC Polymer Science GA AX8CO UT WOS:000347138300002 ER PT J AU McConnell, ER Bell, SM Cote, I Wang, RL Perkins, EJ Garcia-Reyero, N Gong, P Burgoon, LD AF McConnell, Emma R. Bell, Shannon M. Cote, Ila Wang, Rong-Lin Perkins, Edward J. Garcia-Reyero, Natalia Gong, Ping Burgoon, Lyle D. TI Systematic Omics Analysis Review (SOAR) Tool to Support Risk Assessment SO PLOS ONE LA English DT Review ID GENE-EXPRESSION; CIGARETTE-SMOKE; DIESEL EXHAUST; TRANSCRIPTOME; TCDD; MICROARRAY; EXPOSURE; CELLS AB Environmental health risk assessors are challenged to understand and incorporate new data streams as the field of toxicology continues to adopt new molecular and systems biology technologies. Systematic screening reviews can help risk assessors and assessment teams determine which studies to consider for inclusion in a human health assessment. A tool for systematic reviews should be standardized and transparent in order to consistently determine which studies meet minimum quality criteria prior to performing in-depth analyses of the data. The Systematic Omics Analysis Review (SOAR) tool is focused on assisting risk assessment support teams in performing systematic reviews of transcriptomic studies. SOAR is a spreadsheet tool of 35 objective questions developed by domain experts, focused on transcriptomic microarray studies, and including four main topics: test system, test substance, experimental design, and microarray data. The tool will be used as a guide to identify studies that meet basic published quality criteria, such as those defined by the Minimum Information About a Microarray Experiment standard and the Toxicological Data Reliability Assessment Tool. Seven scientists were recruited to test the tool by using it to independently rate 15 published manuscripts that study chemical exposures with microarrays. Using their feedback, questions were weighted based on importance of the information and a suitability cutoff was set for each of the four topic sections. The final validation resulted in 100% agreement between the users on four separate manuscripts, showing that the SOAR tool may be used to facilitate the standardized and transparent screening of microarray literature for environmental human health risk assessment. C1 [McConnell, Emma R.; Bell, Shannon M.] Oak Ridge Inst Sci & Educ, Res Triangle Pk, NC USA. [Cote, Ila] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Arlington, VA USA. [Wang, Rong-Lin] US EPA, Natl Exposure Res Lab, Off Res & Dev, Cincinnati, OH USA. [Perkins, Edward J.] US Army, Corps Engineers, Dept Army, Dept Def, Vicksburg, MS 39180 USA. [Garcia-Reyero, Natalia] Jackson State Univ, Dept Chem & Biochem, Jackson, MS USA. [Gong, Ping] SpecPro Inc, Vicksburg, MS USA. [Burgoon, Lyle D.] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Res Triangle Pk, NC 27711 USA. RP Burgoon, LD (reprint author), US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Res Triangle Pk, NC 27711 USA. EM Burgoon.Lyle@epa.gov OI Burgoon, Lyle/0000-0003-4977-5352 FU US EPA's Human Health Risk Assessment Program; SpecPro, Inc FX This work was funded by the US EPA's Human Health Risk Assessment Program. The funders had no role in study design, or data collection and analysis. EPA management cleared the manuscript for publication, which included helpful suggestions that improved the overall quality of the manuscript, consistent with the US EPA Scientific Integrity Policy. Co-author Ping Gong is employed by SpecPro, Inc. SpecPro, Inc provided support in the form of salary for author PG, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific role of this author is articulated in the 'author contributions' section. NR 29 TC 3 Z9 3 U1 1 U2 13 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 22 PY 2014 VL 9 IS 12 AR UNSP e110379 DI 10.1371/journal.pone.0110379 PG 14 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CA3ZY UT WOS:000348845100002 PM 25531884 ER PT J AU Farquharson, S Shende, C Smith, W Huang, H Inscore, F Sengupta, A Sperry, J Sickler, T Prugh, A Guicheteau, J AF Farquharson, Stuart Shende, Chetan Smith, Wayne Huang, Hermes Inscore, Frank Sengupta, Atanu Sperry, Jay Sickler, Todd Prugh, Amber Guicheteau, Jason TI Selective detection of 1000 B. anthracis spores within 15 minutes using a peptide functionalized SERS assay SO ANALYST LA English DT Article ID SURFACE-ENHANCED RAMAN; BACILLUS-ANTHRACIS; DIPICOLINIC ACID; SPECTROSCOPY; SUBTILIS; ADSORPTION; EXTRACTION; PROTEINS; CEREUS; PCR AB A surface-enhanced Raman spectroscopy (SERS) assay has been designed to detect Bacillus anthracis spores. The assay consists of silver nanoparticles embedded in a porous glass structure that have been functionalized with ATYPLPIR, a peptide developed to discriminately bind B. anthracis versus other species of Bacillus. Once bound, acetic acid was used to release the biomarker dipicolinic acid from the spores, which was detected by SERS through the addition of silver colloids. This SERS assay was used to selectively bind B. anthracis with a 100-fold selectivity versus B. cereus, and to detect B. anthracis Ames at concentrations of 1000 spores per mL within 15 minutes. The SERS assay measurements provide a basis for the development of systems that can detect spores collected from the air or from water supplies. C1 [Farquharson, Stuart; Shende, Chetan; Smith, Wayne; Inscore, Frank] Real Time Analyzers Inc, Middletown, CT 06457 USA. [Huang, Hermes] Smiths Detect, Danbury, CT 06810 USA. [Sengupta, Atanu] Dr Reddys Labs, Bachupally 500090, Andhra Pradesh, India. [Sperry, Jay] Univ Rhode Isl, Dept Cell & Mol Biol, Kingston, RI 02881 USA. [Sickler, Todd; Prugh, Amber; Guicheteau, Jason] US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Farquharson, S (reprint author), Real Time Analyzers Inc, 362 Ind Pk Rd,Unit 8, Middletown, CT 06457 USA. EM stu@rta.biz FU Defense Advanced Research Projects Agency [N10PC2077, D11PC20171]; National Science Foundation [DMI-0349687, IIP-0810335, II-0956170] FX The authors are grateful for funding from the Defense Advanced Research Projects Agency (N10PC2077 and D11PC20171) and the National Science Foundation (DMI-0349687, IIP-0810335, and II-0956170). NR 42 TC 5 Z9 5 U1 6 U2 52 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 0003-2654 EI 1364-5528 J9 ANALYST JI Analyst PD DEC 21 PY 2014 VL 139 IS 24 BP 6366 EP 6370 DI 10.1039/c4an01163e PG 5 WC Chemistry, Analytical SC Chemistry GA AT9SB UT WOS:000345265300007 PM 25263740 ER PT J AU Yuffa, AJ Gurton, KP Videen, G AF Yuffa, Alex J. Gurton, Kristan P. Videen, Gorden TI Three-dimensional facial recognition using passive long-wavelength infrared polarimetric imaging SO APPLIED OPTICS LA English DT Article ID HUMAN SKIN; OPTICAL-PROPERTIES; IN-VIVO; SURFACE; POLARIZATION; SHAPE; RADIATION; TISSUES; RANGE; FIELD AB We use a polarimetric camera to record the Stokes parameters and the degree of linear polarization of long-wavelength infrared radiation emitted by human faces. These Stokes images are combined with Fresnel relations to extract the surface normal at each pixel. Integrating over these surface normals yields a three-dimensional facial image. One major difficulty of this technique is that the normal vectors determined from the polarizations are not unique. We overcome this problem by introducing an additional boundary condition on the subject. The major sources of error in producing inversions are noise in the images caused by scattering of the background signal and the ambiguity in determining the surface normals from the Fresnel coefficients. (C) 2014 Optical Society of America C1 [Yuffa, Alex J.; Gurton, Kristan P.; Videen, Gorden] US Army Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA. RP Yuffa, AJ (reprint author), US Army Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA. EM ayuffa@gmail.com RI Yuffa, Alex/B-5498-2014 OI Yuffa, Alex/0000-0002-3600-1131 FU U.S. Army Research Laboratory Postdoctoral Fellowship Program FX This research was supported in part by an appointment to the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through a cooperative agreement with the U.S. Army Research Laboratory. NR 32 TC 5 Z9 5 U1 1 U2 9 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD DEC 20 PY 2014 VL 53 IS 36 BP 8514 EP 8521 DI 10.1364/AO.53.008514 PG 8 WC Optics SC Optics GA AX3ED UT WOS:000346822300018 PM 25608201 ER PT J AU Wiehe, K Easterhoff, D Luo, K Nicely, NI Bradley, T Jaeger, FH Dennison, SM Zhang, RJ Lloyd, KE Stolarchuk, C Parks, R Sutherland, LL Scearce, RM Morris, L Kaewkungwal, J Nitayaphan, S Pitisuttithum, P Rerks-Ngarm, S Sinangil, F Phogat, S Michael, NL Kim, JH Kelsoe, G Montefiori, DC Tomaras, GD Bonsignori, M Santra, S Kepler, TB Alam, SM Moody, MA Liao, HX Haynes, BF AF Wiehe, Kevin Easterhoff, David Luo, Kan Nicely, Nathan I. Bradley, Todd Jaeger, Frederick H. Dennison, S. Moses Zhang, Ruijun Lloyd, Krissey E. Stolarchuk, Christina Parks, Robert Sutherland, Laura L. Scearce, Richard M. Morris, Lynn Kaewkungwal, Jaranit Nitayaphan, Sorachai Pitisuttithum, Punnee Rerks-Ngarm, Supachai Sinangil, Faruk Phogat, Sanjay Michael, Nelson L. Kim, Jerome H. Kelsoe, Garnett Montefiori, David C. Tomaras, Georgia D. Bonsignori, Mattia Santra, Sampa Kepler, Thomas B. Alam, S. Munir Moody, M. Anthony Liao, Hua-Xin Haynes, Barton F. TI Antibody Light-Chain-Restricted Recognition of the Site of Immune Pressure in the RV144 HIV-1 Vaccine Trial Is Phylogenetically Conserved SO IMMUNITY LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; PROXIMAL EXTERNAL REGION; NEUTRALIZING ANTIBODIES; MONOCLONAL-ANTIBODIES; EFFICACY TRIAL; GP41; REACTIVITY; AFFINITY; BINDING; IDENTIFICATION AB In HIV-1, the ability to mount antibody responses to conserved, neutralizing epitopes is critical for protection. Here we have studied the light chain usage of human and rhesus macaque antibodies targeted to a dominant region of the HIV-1 envelope second variable (V2) region involving lysine (K) 169, the site of immune pressure in the RV144 vaccine efficacy trial. We found that humans and rhesus macaques used orthologous lambda variable gene segments encoding a glutamic acid-aspartic acid (ED) motif for K169 recognition. Structure determination of an unmutated ancestor antibody demonstrated that the V2 binding site was preconfigured for ED motifmediated recognition prior to maturation. Thus, light chain usage for recognition of the site of immune pressure in the RV144 trial is highly conserved across species. These data indicate that the HIV-1 K169-recognizing ED motif has persisted over the diversification between rhesus macaques and humans, suggesting an evolutionary advantage of this antibody recognition mode. C1 [Wiehe, Kevin; Easterhoff, David; Luo, Kan; Nicely, Nathan I.; Bradley, Todd; Jaeger, Frederick H.; Dennison, S. Moses; Zhang, Ruijun; Lloyd, Krissey E.; Stolarchuk, Christina; Parks, Robert; Sutherland, Laura L.; Scearce, Richard M.; Kelsoe, Garnett; Montefiori, David C.; Tomaras, Georgia D.; Bonsignori, Mattia; Alam, S. Munir; Moody, M. Anthony; Liao, Hua-Xin; Haynes, Barton F.] Duke Univ, Sch Med, Duke Human Vaccine Inst, Durham, NC 27710 USA. [Morris, Lynn] Natl Inst Communicable Dis, ZA-2131 Johannesburg, South Africa. [Morris, Lynn] Ctr AIDS Programme Res South Africa CAPRISA, Durban, South Africa. [Kaewkungwal, Jaranit; Pitisuttithum, Punnee] Mahidol Univ, Dept Trop Med, Bangkok 10400, Thailand. [Nitayaphan, Sorachai] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi 11000, Thailand. [Sinangil, Faruk] Sanofi Pasteur Inc, Swiftwater, PA 18370 USA. [Phogat, Sanjay] Global Solut Infect Dis, San Francisco, CA 94080 USA. [Michael, Nelson L.; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil Res Program, Silver Spring, MD 20910 USA. [Santra, Sampa] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Boston, MA 02215 USA. [Kepler, Thomas B.] Boston Univ, Dept Microbiol, Boston, MA 02118 USA. RP Wiehe, K (reprint author), Duke Univ, Sch Med, Duke Human Vaccine Inst, Durham, NC 27710 USA. EM kevin.wiehe@dm.duke.edu; barton.haynes@dm.duke.edu RI Tomaras, Georgia/J-5041-2016 FU Collaboration for AIDS Vaccine Discovery from the Bill & Melinda Gates Foundation [OPP1033098]; Center for HIV/AIDS Vaccine Immunology-Immuongen Discovery (CHAVI-ID) from NIH/NIAID/DAIDS [UMI-AI100645]; Duke University Center for AIDS Research Flow Cytometry core (NIAID, NIH) [P30-AI-64518]; U.S. Army Medical Research and Material Command (USAMRMC) [Y1-AI-2642-12]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DOD) [W81XWH-07-2-0067]; U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [W-31-109-Eng-38]; NIAID (NIH) [5T32-AI007392] FX This work was supported by Collaboration for AIDS Vaccine Discovery grants from the Bill & Melinda Gates Foundation (grant ID OPP1033098) and by the Center for HIV/AIDS Vaccine Immunology-Immuongen Discovery (CHAVI-ID; UMI-AI100645) grant from NIH/NIAID/DAIDS. This work was also supported by grant number 5T32-AI007392 from the NIAID (NIH). Flow cytometry work was additionally supported by The Duke University Center for AIDS Research Flow Cytometry core (NIAID, NIH, CFAR grant P30-AI-64518). Funding was also provided by Interagency Agreement Y1-AI-2642-12 between U.S. Army Medical Research and Material Command (USAMRMC) and the (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD). The views expressed in this article are those of the authors and should not be construed as official or as representing the views of the Department of Defense or the Department of the Army. Use of the Advanced Photon Source was supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No. W-31-109-Eng-38. We thank A. Foulger for expert technical assistance in antibody production; D. Marshall and J. Whitesides for expert technical assistance in flow cytometry; A. Martelli for expert technical assistance in neutralization assays; and K. Soderberg and S. Bowen for project management. NR 43 TC 20 Z9 20 U1 1 U2 4 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 1074-7613 EI 1097-4180 J9 IMMUNITY JI Immunity PD DEC 18 PY 2014 VL 41 IS 6 BP 909 EP 918 DI 10.1016/j.immuni.2014.11.014 PG 10 WC Immunology SC Immunology GA AX0PM UT WOS:000346654100010 PM 25526306 ER PT J AU Fasinu, PS Tekwani, BL Nanayakkara, NPD Avula, B Herath, HMTB Wang, YH Adelli, VR Elsohly, MA Khan, SI Khan, IA Pybus, BS Marcsisin, SR Reichard, GA McChesney, JD Walker, LA AF Fasinu, Pius S. Tekwani, Babu L. Nanayakkara, N. P. Dhammika Avula, Bharathi Herath, H. M. T. Bandara Wang, Yan-Hong Adelli, Vijender R. Elsohly, Mahmoud A. Khan, Shabana I. Khan, Ikhlas A. Pybus, Brandon S. Marcsisin, Sean R. Reichard, Gregory A. McChesney, James D. Walker, Larry A. TI Enantioselective metabolism of primaquine by human CYP2D6 SO MALARIA JOURNAL LA English DT Article DE Primaquine enantiomers; CYP2D6; Metabolism; Ring-hydroxylation; Quinone-imines; Orthoquinone ID INDUCED HEMOLYTIC-ANEMIA; ANTIMALARIAL-DRUG PRIMAQUINE; HUMAN-ERYTHROCYTES; RAT ERYTHROCYTES; VIVAX MALARIA; 5-HYDROXYPRIMAQUINE; 8-AMINOQUINOLINES; PHARMACOKINETICS; IDENTIFICATION; HEMOTOXICITY AB Background: Primaquine, currently the only approved drug for the treatment and radical cure of Plasmodium vivax malaria, is still used as a racemic mixture. Clinical use of primaquine has been limited due to haemolytic toxicity in individuals with genetic deficiency in glucose-6-phosphate dehydrogenase. Earlier studies have linked its therapeutic effects to CYP2D6-generated metabolites. The aim of the current study was to investigate the differential generation of the CYP2D6 metabolites by racemic primaquine and its individual enantiomers. Methods: Stable isotope C-13-labelled primaquine and its two enantiomers were incubated with recombinant cytochrome-P450 supersomes containing CYP2D6 under optimized conditions. Metabolite identification and time-point quantitative analysis were performed using LC-MS/MS. UHPLC retention time, twin peaks with a mass difference of 6, MS-MS fragmentation pattern, and relative peak area with respect to parent compound were used for phenotyping and quantitative analysis of metabolites. Results: The rate of metabolism of (+)-(S)-primaquine was significantly higher (50% depletion of 20 mu M in 120 min) compared to (-)-(R)-primaquine (30% depletion) when incubated with CYP2D6. The estimated V-max (mu mol/min/mg) were 0.75, 0.98 and 0.42, with K-m (mu M) of 24.2, 33.1 and 21.6 for (+/-)-primaquine, (+)-primaquine and (-)-primaquine, respectively. Three stable mono-hydroxylated metabolites, namely, 2-, 3-and 4-hydroxyprimaquine (2-OH-PQ, 3-OH-PQ, and 4-OH-PQ), were identified and quantified. 2-OH-PQ was preferentially formed from (+)-primaquine in a ratio of 4: 1 compared to (-)-primaquine. The racemic (+/-)-primaquine showed a pattern similar to the (-)-primaquine; 2-OH-PQ accounted for about 15-17% of total CYP2D6-mediated conversion of (+)-primaquine. In contrast, 4-OH-PQ was preferentially formed with (-)-primaquine (5: 1), accounting for 22% of the total (-)-primaquine conversion. 3-OH-PQ was generated from both enantiomers and racemate. 5-hydroxyprimaquine was unstable. Its orthoquinone degradation product (twice as abundant in (+)-primaquine compared to (-)-primaquine) was identified and accounted for 18-20% of the CYP2D6-mediated conversion of (+)-primaquine. Other minor metabolites included dihydroxyprimaquine species, two quinone-imine products of dihydroxylated primaquine, and a primaquine terminal alcohol with variable generation from the individual enantiomers. Conclusion: The metabolism of primaquine by human CYP2D6 and the generation of its metabolites display enantio-selectivity regarding formation of hydroxylated product profiles. This may partly explain differential pharmacologic and toxicologic properties of primaquine enantiomers. C1 [Fasinu, Pius S.; Tekwani, Babu L.; Nanayakkara, N. P. Dhammika; Avula, Bharathi; Herath, H. M. T. Bandara; Wang, Yan-Hong; Adelli, Vijender R.; Elsohly, Mahmoud A.; Khan, Shabana I.; Khan, Ikhlas A.; Walker, Larry A.] Univ Mississippi, Natl Ctr Nat Prod Res, University, MS 38677 USA. [Tekwani, Babu L.; Khan, Shabana I.; Khan, Ikhlas A.; Walker, Larry A.] Univ Mississippi, BioMol Sci, University, MS 38677 USA. [Elsohly, Mahmoud A.] Univ Mississippi, Sch Pharm, University, MS 38677 USA. [Elsohly, Mahmoud A.] ElSohly Labs Inc, Oxford, MS 38655 USA. [Pybus, Brandon S.; Marcsisin, Sean R.; Reichard, Gregory A.] Walter Reed Army Inst Res, Div Expt Therapeut, Mil Malaria Res Program, Silver Spring, MD 20910 USA. [McChesney, James D.] Ironstone Separat Inc, Etta, MS 38627 USA. RP Walker, LA (reprint author), Univ Mississippi, Natl Ctr Nat Prod Res, University, MS 38677 USA. EM lwalker@olemiss.edu FU Bill and Melinda Gates Foundation Phase I GCE Award [OPP53288]; US Army Medical Research and Materiel Command Awards [W81XWH-07-2-0095, W81XWH-10-2-0059] FX This study is supported by Bill and Melinda Gates Foundation Phase I GCE Award OPP53288 and the US Army Medical Research and Materiel Command Awards Nos. W81XWH-07-2-0095 and W81XWH-10-2-0059 to the University of Mississippi. The authors thank Dr David Jollow, Medical University of South Carolina, retired, for his continuing input and advice and help in interpretation. NR 37 TC 9 Z9 9 U1 1 U2 9 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD DEC 17 PY 2014 VL 13 AR 507 DI 10.1186/1475-2875-13-507 PG 12 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AY4UW UT WOS:000347574300001 PM 25518709 ER PT J AU Deng, YP Ai, JM Guan, X Wang, ZH Yan, B Zhang, DQ Liu, C Wilbanks, MS Escalon, BL Meyers, SA Yang, MQ Perkins, EJ AF Deng, Youping Ai, Junmei Guan, Xin Wang, Zhaohui Yan, Bin Zhang, Daqin Liu, Chang Wilbanks, Mitch S. Escalon, Barbara Lynn Meyers, Sharon A. Yang, Mary Qu Perkins, Edward J. TI MicroRNA and messenger RNA profiling reveals new biomarkers and mechanisms for RDX induced neurotoxicity SO BMC GENOMICS LA English DT Article ID BOBWHITE COLINUS-VIRGINIANUS; AXON GUIDANCE; EXPOSURE; EXPRESSION; TARGETS; LIVER; 1,3,5-TRINITRO-1,3,5-TRIAZINE; NEURODEGENERATION; PHOSPHORYLATION; REPRESSION AB Background: RDX is a well-known pollutant to induce neurotoxicity. MicroRNAs (miRNA) and messenger RNA (mRNA) profiles are useful tools for toxicogenomics studies. It is worthy to integrate MiRNA and mRNA expression data to understand RDX-induced neurotoxicity. Results: Rats were treated with or without RDX for 48 h. Both miRNA and mRNA profiles were conducted using brain tissues. Nine miRNAs were significantly regulated by RDX. Of these, 6 and 3 miRNAs were up-and down-regulated respectively. The putative target genes of RDX-regulated miRNAs were highly nervous system function genes and pathways enriched. Fifteen differentially genes altered by RDX from mRNA profiles were the putative targets of regulated miRNAs. The induction of miR-71, miR-27ab, miR-98, and miR-135a expression by RDX, could reduce the expression of the genes POLE4, C5ORF13, SULF1 and ROCK2, and eventually induce neurotoxicity. Overexpression of miR-27ab, or reduction of the expression of unknown miRNAs by RDX, could up-regulate HMGCR expression and contribute to neurotoxicity. RDX regulated immune and inflammation response miRNAs and genes could contribute to RDX-induced neurotoxicity and other toxicities as well as animal defending reaction response to RDX exposure. Conclusions: Our results demonstrate that integrating miRNA and mRNA profiles is valuable to indentify novel biomarkers and molecular mechanisms for RDX-induced neurological disorder and neurotoxicity. C1 [Deng, Youping; Wang, Zhaohui; Liu, Chang] Wuhan Univ Sci & Technol, Wuhan 430081, Hubei, Peoples R China. [Deng, Youping; Ai, Junmei] Rush Univ, Med Ctr, Dept Internal Med & Biochem, Chicago, IL 60612 USA. [Guan, Xin] Bristol Bay Native Corp, Vicksburg, MS 39180 USA. [Yan, Bin] Hong Kong Baptist Univ, Dept Biol, Kowloon, Hong Kong, Peoples R China. [Yan, Bin] Univ Hong Kong, LKS Fac Med, Stem Cell & Regenerat Med Consortium, Hong Kong, Hong Kong, Peoples R China. [Yan, Bin] Univ Hong Kong, Dept Physiol, Hong Kong, Hong Kong, Peoples R China. [Zhang, Daqin] Soochow Univ, Ctr Syst Biol, Sch Math Sci, Suzhou 215006, Jiangsu, Peoples R China. [Wilbanks, Mitch S.; Escalon, Barbara Lynn; Perkins, Edward J.] US Army, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Meyers, Sharon A.] NE Louisiana Univ, Sch Pharm, Monroe, LA 71209 USA. [Wang, Zhaohui] Wuhan Univ Sci & Technol, Sch Comp Sci & Technol, Wuhan 430081, Hubei, Peoples R China. [Yang, Mary Qu] Univ Arkansas, George W Donaghey Coll Engn & Informat Technol, MidSouth Bioinformat Ctr, Dept Informat Sci, Little Rock, AR 72204 USA. [Yang, Mary Qu] Univ Arkansas, Joint Bioinformat Grad Program, Little Rock, AR 72204 USA. [Yang, Mary Qu] Univ Arkansas Med Sci, Little Rock, AR 72204 USA. RP Deng, YP (reprint author), Wuhan Univ Sci & Technol, Wuhan 430081, Hubei, Peoples R China. EM youping_deng@rush.edu FU Natural Science Foundation Hubei Province of China [2011CDB236]; United States National Institutes of Health (NIH); NIH/NIGMS [5P20GM10342913]; ASTA [15-B-23]; NIH/NCI [R21CA164764] FX This work and its publication were supported by research grants from Natural Science Foundation Hubei Province of China (2011CDB236) and United States National Institutes of Health (NIH). MQY was supported by NIH/NIGMS 5P20GM10342913 and ASTA award # 15-B-23. YD was supported by NIH/NCI R21CA164764. NR 43 TC 6 Z9 6 U1 0 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2164 J9 BMC GENOMICS JI BMC Genomics PD DEC 16 PY 2014 VL 15 SU 11 AR S1 DI 10.1186/1471-2164-15-S11-S1 PG 12 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA CH4CE UT WOS:000353978200002 PM 25559034 ER PT J AU Ruiz, S Wolfe, DN AF Ruiz, Sara Wolfe, Daniel N. TI Vaccination against Q fever for biodefense and public health indications SO FRONTIERS IN MICROBIOLOGY LA English DT Article DE Q fever; vaccine; biodefense; Coxiella; epidemiology ID COXIELLA-BURNETII INFECTION; METHANOL RESIDUE VACCINE; HIGH-RISK PATIENTS; PHASE-I; SEROEPIDEMIOLOGICAL SURVEY; IMMUNE-RESPONSES; BLOOD-DONORS; US MILITARY; BALB/C MICE; SEROPREVALENCE AB Coxiella bumetii is the etiological agent of Q fever, a disease that is often spread to humans via inhalational exposure to the bacteria from contaminated agricultural sources. Outbreaks have been observed all over the world with larger foci generating interest in vaccination programs, most notably in Australia and the Netherlands. Importantly, exposure rates among military personnel deployed to the Middle East can be relatively high as measured by seroconversion to C. bumetii-specific antibodies. Q fever has been of interest to the biodefense community over the years due to its low infectious dose and environmental stability. Recent advances in cell-free growth and genetics of C. bumetii also make this organism easier to culture and manipulate. While there is a vaccine that is licensed for use in Australia, the combination of biodefense- and public health-related issues associated with Q fever warrant the development of a safer and more effective vaccine against this disease. C1 [Ruiz, Sara] US Army Med Res Inst Infect Dis, Ctr Aerobiol Sci, Ft Detrick, MD USA. [Wolfe, Daniel N.] Def Threat Reduct Agcy, Chem Biol Technol Dept, Ft Belvoir, VA 22060 USA. RP Wolfe, DN (reprint author), Def Threat Reduct Agcy, Chem Biol Technol Dept, 8725 John Kingman Rd, Ft Belvoir, VA 22060 USA. EM daniel.wolfe@dtra.mil NR 85 TC 1 Z9 1 U1 2 U2 23 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1664-302X J9 FRONT MICROBIOL JI Front. Microbiol. PD DEC 16 PY 2014 VL 5 AR 726 DI 10.3389/fmicb.2014.00726 PG 7 WC Microbiology SC Microbiology GA AX9TD UT WOS:000347244000001 PM 25566235 ER PT J AU Hulse, EJ Davies, JOJ Simpson, AJ Sciuto, AM Eddleston, M AF Hulse, Elspeth J. Davies, James O. J. Simpson, A. John Sciuto, Alfred M. Eddleston, Michael TI Respiratory Complications of Organophosphorus Nerve Agent and Insecticide Poisoning Implications for Respiratory and Critical Care SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Review DE Organophosphorus; insecticide; nerve agent; critical care ID ACUTE LUNG INJURY; VENTILATOR-ASSOCIATED PNEUMONIA; MUSCARINIC ACETYLCHOLINE-RECEPTORS; RANDOMIZED CONTROLLED-TRIAL; GASTRIC-ACID-SECRETION; INTERMEDIATE SYNDROME; DISTRESS-SYNDROME; PULMONARY-EDEMA; ASPIRATION PNEUMONITIS; INHALATION TOXICITY AB Organophosphorus (OP) compound poisoning is a major global public health problem. Acute OP insecticide self-poisoning kills over 200,000 people every year, the majority from self-harm in rural Asia. Highly toxic OP nerve agents (e.g., sarin) are a significant current terrorist threat, as shown by attacks in Damascus during 2013. These anticholinesterase compounds are classically considered to cause an acute cholinergic syndrome with decreased consciousness, respiratory failure, and, in the case of insecticides, a delayed intermediate syndrome that requires prolonged ventilation. Acute respiratory failure, by central and peripheral mechanisms, is the primary-cause of death in most cases, However, preclinical and clinical research over the last two decades has indicated a more complex picture of respiratory complications after OP insecticide poisoning, including onset of delayed neuromuscular junction dysfunction during the cholinergic syndrome, aspiration causing pneumonia and acute respiratory distress syndrome, and the involvement of solvents in OP toxicity. The treatment of OP poisoning has not changed over the last 50 years. However, a better understanding of the multiple respiratory complications of OP poisoning offers additional therapeutic opportunities. C1 [Hulse, Elspeth J.; Eddleston, Michael] Univ Edinburgh, BHF Ctr Cardiovasc Sci, Edinburgh, Midlothian, Scotland. [Hulse, Elspeth J.; Davies, James O. J.; Eddleston, Michael] Univ Peradeniya, South Asian Clin Toxicol Res Collaborat, Peradeniya, Sri Lanka. [Davies, James O. J.] Univ Oxford, Weatherall Inst Mol Med, Oxford, England. [Simpson, A. John] Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England. [Sciuto, Alfred M.] US Army Med Res Inst Chem Def, Analyt Toxicol Div, Aberdeen Proving Ground, MD USA. RP Eddleston, M (reprint author), Queens Med Res Inst, E3-20,47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, Scotland. EM m.eddleston@ed.ac.uk FU Wellcome Trust [063560, 085979, 090886] FX Supported by Wellcome Trust grants 063560, 085979, and 090886. NR 115 TC 8 Z9 14 U1 2 U2 17 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PD DEC 15 PY 2014 VL 190 IS 12 BP 1342 EP 1354 DI 10.1164/rccm.201406-1150CI PG 13 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA AX4IG UT WOS:000346896000009 PM 25419614 ER PT J AU Martin, WA Nestler, CC Wynter, M Larson, SL AF Martin, W. Andy Nestler, Catherine C. Wynter, Michelle Larson, Steven L. TI Bullet on bullet fragmentation profile in soils SO JOURNAL OF ENVIRONMENTAL MANAGEMENT LA English DT Article DE Pb; Sb; Cu; Fragmentation; Bullet; Soil ID ANTIMONY; RANGE; LEAD AB Lead-antimony alloy slugs encased in a brass jackets are common small arms caliber ammunition used for training and target practice. When small caliber ammunition is fired at testing and training ranges, these metals-some of which are toxic-are introduced into the environment. Research was conducted on the effects of bullet on bullet impacts and the resulting bullet fragmentation. The extent of bullet fragmentation, among other factors, affects the formation of mobile metal species from small arms firing ranges. Bullet on bullet impact can increase the surface area to mass ratio of the bullet metal alloys in the soil. The solubility of a metal is typically associated with the specific corrosion rate in the berm environment which is dependent on the surface area of the fragments. The purpose of the study was to analyze the bullet on bullet impact effects in six soil types. Changes in the metal distribution as a result of bullet impact was evaluated through sieve analysis and changes in the particle size distribution. The bullet on bullet impact observed in this study demonstrated a significant and observable shift in the fragmentation profiles for the lead, antimony, and copper in soils after shooting an average of 1050 tungsten-nylon bullets into the legacy lead soils. This study provides new information to assist with determining the potential environmental fate, transport, and environmental availability associated with constant bullet on bullet impact at testing and training ranges. Published by Elsevier Ltd. C1 [Martin, W. Andy; Wynter, Michelle; Larson, Steven L.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Martin, W. Andy] Purdue Univ, Dept Agron, W Lafayette, IN 47907 USA. [Nestler, Catherine C.] Appl Res Associates Inc, Vicksburg, MS 39180 USA. RP Martin, WA (reprint author), Purdue Univ, Dept Agron, W Lafayette, IN 47907 USA. EM Andy.Martin@usace.army.mil FU U.S. Army Armament Research, Development and Engineering Center FX This study would not be possible without the financial support of the U.S. Army Armament Research, Development and Engineering Center. Analytical and technical support was provided by Mr. Chris Griggs and Dr. Chuck Weiss of the U.S. Army Engineer Research and Development Center. Citation of trade names in this manuscript does not constitute an official endorsement or approval of the use of such commercial products. This manuscript was approved for public release by the Chief of Engineers. NR 14 TC 1 Z9 1 U1 2 U2 29 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0301-4797 EI 1095-8630 J9 J ENVIRON MANAGE JI J. Environ. Manage. PD DEC 15 PY 2014 VL 146 BP 369 EP 372 DI 10.1016/j.jenvman.2014.04.041 PG 4 WC Environmental Sciences SC Environmental Sciences & Ecology GA AR5HA UT WOS:000343614400040 PM 25201767 ER PT J AU Singamaneni, SR Fan, W Prater, JT Narayan, J AF Singamaneni, Srinivasa Rao Fan, Wu Prater, J. T. Narayan, J. TI Magnetic properties of BaTiO3/La0.7Sr0.3MnO3 thin films integrated on Si(100) SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID PULSED-LASER DEPOSITION; BATIO3 FILMS; SILICON; HETEROSTRUCTURES; GROWTH AB Two-phase multiferroic heterostructures composed of room-temperature ferroelectric BaTiO3 (BTO) and ferromagnetic La0.7Sr0.3MnO3 (LSMO) epitaxial thin films were grown on technologically important substrate Si (100). Bilayers of BTO/LSMO thin films display ferromagnetic Curie transition temperatures of similar to 350K, close to the bulk value, which are independent of BTO films thickness in the range of 25-100 nm. Discontinuous magnetization jumps associated with BTO structural transitions were suppressed in M(T) curves, probably due to substrate clamping effect. Interestingly, at cryogenic temperatures, the BTO/LSMO structure with BTO layer thickness of 100 nm shows almost 2-fold higher magnetic coercive field, 3-fold reduction in saturation magnetization, and improved squareness compared to the sample without BTO. We believe that the strong in-plane spin pinning of the ferromagnetic layer induced by BTO layer at BTO/LSMO interface could cause such changes in magnetic properties. This work forms a significant step forward in the integration of two-phase multiferroic heterostructures for CMOS applications. (C) 2014 AIP Publishing LLC. C1 [Singamaneni, Srinivasa Rao; Prater, J. T.] Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. [Singamaneni, Srinivasa Rao; Fan, Wu; Prater, J. T.; Narayan, J.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. RP Singamaneni, SR (reprint author), Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. EM ssingam@ncsu.edu OI , fan/0000-0001-5000-0592 FU National Academy of Science (NAS), USA of NRC; Army Research Office [W911NF-04-D-0003]; State of North Carolina; National Science Foundation FX S.R.S. acknowledges financial support from the National Academy of Science (NAS), USA in the form of NRC postdoctoral research associate fellowship. We thank Chrstian Binek, University of Nebraska and N. D. Mathur, University of Cambridge for stimulating discussion. Also, the authors are pleased to acknowledge the support of the Army Research Office under Grant W911NF-04-D-0003. Also, the authors acknowledge the use of the Analytical Instrumentation Facility (AIF) at North Carolina State University, which was supported by the State of North Carolina and the National Science Foundation. NR 23 TC 5 Z9 5 U1 3 U2 53 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD DEC 14 PY 2014 VL 116 IS 22 AR 224104 DI 10.1063/1.4903322 PG 6 WC Physics, Applied SC Physics GA AW4QR UT WOS:000346266300042 ER PT J AU Wali, S Gupta, R Veselenak, RL Li, YS Yu, JJ Murthy, AK Cap, AP Guentzel, MN Chambers, JP Zhong, GM Rank, RG Pyles, RB Arulanandam, BP AF Wali, Shradha Gupta, Rishein Veselenak, Ronald L. Li, Yansong Yu, Jieh-Juen Murthy, Ashlesh K. Cap, Andrew P. Guentzel, M. Neal Chambers, James P. Zhong, Guangming Rank, Roger G. Pyles, Richard B. Arulanandam, Bernard P. TI Use of a Guinea Pig-Specific Transcriptome Array for Evaluation of Protective Immunity against Genital Chlamydial Infection following Intranasal Vaccination in Guinea Pigs SO PLOS ONE LA English DT Article ID CD4(+) T-CELLS; INCLUSION CONJUNCTIVITIS; TRACHOMATIS INFECTION; MURIDARUM INFECTION; TRACT INFECTION; MOUSE PNEUMONITIS; ANIMAL-MODELS; HOST RESPONSE; REPRODUCTIVE-TRACT; IFN-GAMMA AB Guinea pigs have been used as a second animal model to validate putative anti-chlamydial vaccine candidates tested in mice. However, the lack of guinea pig-specific reagents has limited the utility of this animal model in Chlamydia sp. vaccine studies. Using a novel guinea pig-specific transcriptome array, we determined correlates of protection in guinea pigs vaccinated with Chlamydia caviae (C. caviae) via the intranasal route, previously reported by us and others to provide robust antigen specific immunity against subsequent intravaginal challenge. C. caviae vaccinated guinea pigs resolved genital infection by day 3 post challenge. In contrast, mock vaccinated animals continued to shed viable Chlamydia up to day 18 post challenge. Importantly, at day 80 post challenge, vaccinated guinea pigs experienced significantly reduced genital pathology - a sequelae of genital chlamydial infections, in comparison to mock vaccinated guinea pigs. Sera from vaccinated guinea pigs displayed antigen specific IgG responses and increased IgG1 and IgG2 titers capable of neutralizing GPIC in vitro. C1 [Wali, Shradha; Gupta, Rishein; Yu, Jieh-Juen; Guentzel, M. Neal; Chambers, James P.; Arulanandam, Bernard P.] Univ Texas San Antonio, South Texas Ctr Emerging Infect Dis, San Antonio, TX 78249 USA. [Wali, Shradha; Gupta, Rishein; Yu, Jieh-Juen; Guentzel, M. Neal; Chambers, James P.; Arulanandam, Bernard P.] Univ Texas San Antonio, Ctr Excellence Infect Genom, San Antonio, TX 78249 USA. [Veselenak, Ronald L.; Pyles, Richard B.] Univ Texas Med Branch, Dept Pediat, Galveston, TX 77555 USA. [Veselenak, Ronald L.; Pyles, Richard B.] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA. [Li, Yansong; Cap, Andrew P.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Murthy, Ashlesh K.] Midwestern Univ, Dept Pathol, Downers Grove, IL 60148 USA. [Zhong, Guangming] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, San Antonio, TX 78229 USA. [Rank, Roger G.] Univ Arkansas Med Sci, Dept Microbiol & Immunol, Little Rock, AR 72202 USA. [Rank, Roger G.] Arkansas Childrens Hosp, Res Inst, Little Rock, AR 72202 USA. RP Arulanandam, BP (reprint author), Univ Texas San Antonio, South Texas Ctr Emerging Infect Dis, One UTSA Circle, San Antonio, TX 78249 USA. EM Bernard.Arulanandam@utsa.edu OI Wali, Shradha/0000-0002-6077-7618 FU National Institutes of Health [1RO1AI074860, 1R03AI092621-01]; Army Research Office of the Department of Defense [W911NF-11-1-0136] FX This work was supported by National Institutes of Health Grant 1RO1AI074860, 1R03AI092621-01 and the Army Research Office of the Department of Defense under Contract No. W911NF-11-1-0136. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 73 TC 1 Z9 1 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 11 PY 2014 VL 9 IS 12 AR e114261 DI 10.1371/journal.pone.0114261 PG 21 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AX8FY UT WOS:000347146700018 PM 25502875 ER PT J AU Haus, T Palunko, I Tolic, D Bogdan, S Lewis, FL Mikulski, DG AF Haus, Tomislav Palunko, Ivana Tolic, Domagoj Bogdan, Stjepan Lewis, Frank L. Mikulski, Dariusz G. TI Trust-based self-organising network control SO IET CONTROL THEORY AND APPLICATIONS LA English DT Article DE multi-agent systems; network theory (graphs); decentralised control; networked control systems; adaptive control; convergence; directed graphs; decentralised trust-based self-organising network control; trust dependent consensus-based mechanism; adaptive control; trust value negotiation; convergence; adaptive mechanism; autonomous agents; decentralised formation control; directed weighted graph; network topology ID CONSENSUS; COORDINATION; COOPERATION; SYSTEMS; AGENTS AB This study proposes a mechanism for decentralised trust-based self-organising network control. The driving force of this work is the idea that some agents are more versed in certain tasks, such as communication, data processing, localisation or trajectory tracking, at a given moment. The author's control objective is to reach an agreement throughout the network regarding each agent's suitability for a certain task. In particular, this study is interested in cultivating network trust towards each agent. Trust values reflect the reputation of each agent within the group. The authors initialise individual trust values towards each agent based on local observations and observations received from the neighbours. Next, a trust-dependent consensus-based mechanism is employed. Since this mechanism is decentralised, scenarios with unequal trusts values towards one agent need to be handled with caution in order not to compromise the collective behaviour. To that end, they employ adaptive control concepts when negotiating trust values. They formally prove convergence of the proposed adaptive mechanism for the network topologies that can be represented with directed weighted graphs. The proposed mechanism is illustrated through a case study of decentralised formation control of autonomous agents. They provide an in-depth analysis of several possible scenarios regarding the proposed control structure. C1 [Haus, Tomislav; Palunko, Ivana; Tolic, Domagoj; Bogdan, Stjepan] Univ Zagreb, Fac Elect Engn & Comp, Zagreb 10000, Croatia. [Lewis, Frank L.] Univ Texas Arlington, Automat & Robot Res Inst, Ft Worth, TX 76118 USA. [Mikulski, Dariusz G.] US Army TARDEC, Warren, MI 48397 USA. RP Haus, T (reprint author), Univ Zagreb, Fac Elect Engn & Comp, Unska 3, Zagreb 10000, Croatia. EM tomislav.haus@fer.hr FU Air Force Research Laboratory [FA8655-13-1-3055]; EU-ICT ASSISIbf [601074] FX This material is based on research sponsored by the Air Force Research Laboratory, under agreement number FA8655-13-1-3055. The U.S. Government is authorised to reproduce and distribute reprints for Governmental purposes notwithstanding any copyright notation thereon. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of the Air Force Research Laboratory or the U.S. Government. This work is partially supported by EU-ICT ASSISIbf, grant number 601074. NR 18 TC 2 Z9 2 U1 3 U2 14 PU INST ENGINEERING TECHNOLOGY-IET PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND SN 1751-8644 EI 1751-8652 J9 IET CONTROL THEORY A JI IET Contr. Theory Appl. PD DEC 11 PY 2014 VL 8 IS 18 SI SI BP 2126 EP 2135 DI 10.1049/iet-cta.2014.0333 PG 10 WC Automation & Control Systems; Engineering, Electrical & Electronic; Instruments & Instrumentation SC Automation & Control Systems; Engineering; Instruments & Instrumentation GA AW1XT UT WOS:000346082700002 ER PT J AU Bartolucci, SF Supan, KE Warrender, JM Davis, CE La Beaud, L Knowles, K Wiggins, JS AF Bartolucci, Stephen F. Supan, Karen E. Warrender, Jeffrey M. Davis, Christopher E. La Beaud, Lawrence Knowles, Kyler Wiggins, Jeffrey S. TI Laser-induced thermo-oxidative degradation of carbon nanotube/polypropylene nanocomposites SO COMPOSITES SCIENCE AND TECHNOLOGY LA English DT Article DE Nanocomposites; Carbon nanotubes; Nanoclays; Thermal properties; High-temperature properties ID LAYERED-SILICATE NANOCOMPOSITES; FLAMMABILITY PROPERTIES; POLYMER NANOCOMPOSITES; FIRE BEHAVIOR; NANOTUBE NANOCOMPOSITES; POLYPROPYLENE; COMPOSITES; DISPERSION; PYROLYSIS; COATINGS AB Nanocomposites of multi-walled carbon nanotubes and polypropylene were fabricated using twin screw extrusion and subjected to heating rates on the order of 100,000 degrees per second using laser pulse heating. Raman and infrared spectroscopy, as well as electron microscopy observations, showed that the nanotubes retain their structure and that a nanotube-rich layer formed at the surface of the composites during laser heating. By varying the weight fraction of filler in the composites, a 54% reduction in mass loss per laser pulse was achieved, compared to the pure polymer. The nanotube composites also displayed lower mass loss than nanoclay composites under the same conditions, despite having a significantly lower weight fraction of additive. Further reduction in mass loss per laser pulse was achieved in solvent-processed samples, which appear to have better dispersion than the extrusion-processed composites. We attribute these observations to the formation of a nanotube network formed on the surface, which acts as a protective barrier, slowing the degradation of the underlying polymer. Several observations made in this study are consistent with those reported in previously published slow heating rate studies, showing that while some phenomena are unique to transient heating, there are some commonalities between the two regimes. Published by Elsevier Ltd. C1 [Bartolucci, Stephen F.; Supan, Karen E.; Warrender, Jeffrey M.; Davis, Christopher E.] US Army, Benet Labs, Armaments Res Dev & Engn Ctr, Watervliet, NY 12189 USA. [Supan, Karen E.] Norwich Univ, Dept Mech Engn, Northfield, VT 05663 USA. [Davis, Christopher E.] MIT, Dept Chem Engn, Cambridge, MA 02139 USA. [La Beaud, Lawrence; Knowles, Kyler; Wiggins, Jeffrey S.] Univ So Mississippi, Sch Polymers & High Performance Mat, Hattiesburg, MS 39406 USA. RP Bartolucci, SF (reprint author), US Army, Benet Labs, Armaments Res Dev & Engn Ctr, 1 Buffington St, Watervliet, NY 12189 USA. OI Knowles, Kyler/0000-0002-0743-6056 NR 30 TC 2 Z9 2 U1 3 U2 13 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0266-3538 EI 1879-1050 J9 COMPOS SCI TECHNOL JI Compos. Sci. Technol. PD DEC 10 PY 2014 VL 105 BP 166 EP 173 DI 10.1016/j.compscitech.2014.09.018 PG 8 WC Materials Science, Composites SC Materials Science GA AX5BZ UT WOS:000346943400021 ER PT J AU Xu, K AF Xu, Kang TI Electrolytes and Interphases in Li-Ion Batteries and Beyond SO CHEMICAL REVIEWS LA English DT Review ID CARBONATE-BASED ELECTROLYTES; LITHIUM SECONDARY BATTERIES; GRAPHITE NEGATIVE-ELECTRODE; SURFACE-FILM FORMATION; RECHARGEABLE MAGNESIUM BATTERIES; LOW-TEMPERATURE PERFORMANCE; SOLID POLYMER ELECTROLYTES; ATOMIC LAYER DEPOSITION; EDGE PLANE GRAPHITE; RAY PHOTOELECTRON-SPECTROSCOPY C1 [Xu, Kang] US Army Res Lab, Sensor & Elect Directorate, Energy & Power Div, Electrochem Branch, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Xu, K (reprint author), US Army Res Lab, Sensor & Elect Directorate, Energy & Power Div, Electrochem Branch, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM conrad.k.xu.civ@mail.mil NR 826 TC 411 Z9 414 U1 193 U2 923 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0009-2665 EI 1520-6890 J9 CHEM REV JI Chem. Rev. PD DEC 10 PY 2014 VL 114 IS 23 BP 11503 EP 11618 DI 10.1021/cr500003w PG 116 WC Chemistry, Multidisciplinary SC Chemistry GA AW5OC UT WOS:000346323200004 PM 25351820 ER PT J AU Bromberg, L Pomerantz, N Schreuder-Gibson, H Hatton, TA AF Bromberg, Lev Pomerantz, Natalie Schreuder-Gibson, Heidi Hatton, T. Alan TI Degradation of Chemical Threats by Brominated Polymer Networks SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH LA English DT Article ID NERVE AGENT VX; POLY(ETHYLENE-ALT-MALEIC ANHYDRIDE) COPOLYMER; N-BROMOSUCCINIMIDE; WARFARE AGENTS; ELECTROCHEMICAL REDUCTION; ANTIMICROBIAL PAINTS; AMBIENT CONDITIONS; OXIDATION; REAGENT; HYDROLYSIS AB Poly(N-bromomaleimide) (PMAi-Br), poly(N-vinylpyrrolidone)-bromine adducts (PVPBr), and poly(ethylene-alt-N-bromomaleimide) (PEMAi-Br) and their cross-linked networks are introduced as reactive, self-decontaminating components of protective barriers. Synthetic routes toward polymaleimides include free-radical copolymerization of maleimide with divinyl cross-linkers as well as amidation of poly(ethylene-alt-maleic anhydride) with urea. The polymers are brominated by bromine in carbon tetrachloride or by copper(II) bromide in dimethylformamide, with the active bromine contents up to and above 4 mequiv/g, or >30 wt %. The brominated polymer networks exhibit considerable swelling in water and possess reversible redox peak potentials in cyclic voltammetry experiments due to the redox reactions of the bromine present in the polymer structures. In acidic aqueous media, PVPBr, PMAi-co-DVB-Br, and PEMAi-Br materials are able to degrade 100% of hydrazine, monomethylhydrazine, and 1,1-dimethylhydrazine down to concentrations below detectable levels of 0.150.25 mM. The hydrazine is converted to nitrogen gas. The insecticide malathion, tested as a simulant of a combat warfare agent VX, is efficiently and selectively oxidized to malaoxon in the presence of the brominated networks, whereas 2-(chloroethyl)ethyl sulfide (CEES), a simulant of the sulfur mustard agent, is rapidly oxidized, in both vapor and liquid states, into its less-toxic sulfone derivative, 1-chloro-2-(ethylsulfinyl)ethane (CEESO), with the only side product being 1,2-bis(ethylthio)ethane. The oxidation of CEES is proven to be selective, in that no toxic overoxidized CEES analogue, 1-chloro-2-(ethylsulfonyl)ethane, is formed. The developed brominated polymer networks are versatile materials with potential applications in coatings, filters, fabrics, and sorbents. C1 [Bromberg, Lev; Hatton, T. Alan] MIT, Dept Chem Engn, Cambridge, MA 02139 USA. [Pomerantz, Natalie; Schreuder-Gibson, Heidi] US Army Natick Soldier Res, Ctr Dev & Engn, Mat & Def Sci Div, Natick, MA 01760 USA. RP Hatton, TA (reprint author), MIT, Dept Chem Engn, Cambridge, MA 02139 USA. EM tahatton@mit.edu FU Defense Threat Reduction Agency under Army Research Office [W911NF-13-D-0001] FX This work was supported by the Defense Threat Reduction Agency under Army Research Office Grant W911NF-13-D-0001. NR 87 TC 12 Z9 12 U1 1 U2 42 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0888-5885 J9 IND ENG CHEM RES JI Ind. Eng. Chem. Res. PD DEC 10 PY 2014 VL 53 IS 49 BP 18761 EP 18774 DI 10.1021/ie501055g PG 14 WC Engineering, Chemical SC Engineering GA AW5NR UT WOS:000346322200018 ER PT J AU Wang, RL Bencic, DC Garcia-Reyero, N Perkins, EJ Villeneuve, DL Ankley, GT Biales, AD AF Wang, Rong-Lin Bencic, David C. Garcia-Reyero, Natalia Perkins, Edward J. Villeneuve, Daniel L. Ankley, Gerald T. Biales, Adam D. TI Natural Variation in Fish Transcriptomes: Comparative Analysis of the Fathead Minnow (Pimephales promelas) and Zebrafish (Danio rerio) SO PLOS ONE LA English DT Article ID GENE-EXPRESSION SIGNATURES; NOISE; CONSEQUENCES; MECHANISMS; PLATFORMS; MOLECULES; EVOLUTION; VARIANCE; PROFILES; PATTERNS AB Fathead minnow and zebrafish are among the most intensively studied fish species in environmental toxicogenomics. To aid the assessment and interpretation of subtle transcriptomic effects from treatment conditions of interest, better characterization and understanding are needed for natural variation in gene expression among fish individuals from lab cultures. Leveraging the transcriptomics data from a number of our toxicogenomics studies conducted over the years, we conducted a meta-analysis of nearly 600 microarrays generated from the ovary tissue of untreated, reproductively mature fathead minnow and zebrafish samples. As expected, there was considerable batch-to-batch transcriptomic variation; this "batch-effect'' appeared to differentially impact subsets of fish transcriptomes in a nonsystematic way. Temporally more closely spaced batches tended to share a greater transcriptomic similarity among one another. The overall level of within-batch variation was quite low in fish ovary tissue, making it a suitable system for studying chemical stressors with subtle biological effects. The observed differences in the within-batch variability of gene expression, at the levels of both individual genes and pathways, were probably both technical and biological. This suggests that biological interpretation and prioritization of genes and pathways targeted by experimental conditions should take into account both their intrinsic variability and the size of induced transcriptional changes. There was significant conservation of both the genomes and transcriptomes between fathead minnow and zebrafish. The high degree of conservation offers promising opportunities in not only studying fish molecular responses to environmental stressors by a comparative biology approach, but also effective sharing of a large amount of existing public transcriptomics data for developing toxicogenomics applications. C1 [Wang, Rong-Lin; Bencic, David C.; Biales, Adam D.] US EPA, Ecol Exposure Res Div, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. [Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS USA. [Perkins, Edward J.] US Army Corps Engn, US Army Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. [Wang, Rong-Lin; Villeneuve, Daniel L.; Ankley, Gerald T.] US EPA, Midcontinent Ecol Div, Natl Hlth & Environm Effects Res Lab, Duluth, MN USA. RP Wang, RL (reprint author), US EPA, Ecol Exposure Res Div, Natl Exposure Res Lab, Cincinnati, OH 45268 USA. EM wang.rong-lin@epa.gov FU U.S. EPA; U.S. Army [BAA 11-4838] FX Funding was provided by U.S. EPA and U.S. Army (grant BAA 11-4838). The manuscript has been approved for publication by U.S. EPA and U.S. Army Corps Chief of Engineers. The funders had no role in study design, data collection and analysis, or preparation of the manuscript. NR 56 TC 8 Z9 9 U1 3 U2 27 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 10 PY 2014 VL 9 IS 12 AR e114178 DI 10.1371/journal.pone.0114178 PG 24 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AW9YP UT WOS:000346611400034 PM 25493933 ER PT J AU Mion, T Potrepka, DM Crowne, FJ Tauber, A Tidrow, SC AF Mion, Thomas Potrepka, D. M. Crowne, F. J. Tauber, A. Tidrow, Steven C. TI Dielectric and X-ray Diffraction Analysis of Ba(Ga,Ta)(0.05)Ti0.90O3 SO FERROELECTRICS LA English DT Article DE BaTiO3; dopant; dielectric; Rietveld refinement; Barium titanate; dipole-like; X-ray diffraction; substitution; SEM ID FERROELECTRIC MATERIALS; THERMAL-EXPANSION; THIN-FILMS; MICROWAVE; PHASE; POLARIZABILITIES; PEROVSKITES; TECHNOLOGY; CAPACITORS; CERAMICS AB Ba(Ga,Ta)(0.05)Ti0.90O3, a B-site dipole-like substituted material is investigated for structural phase transitions over the temperature range 30 to 900 degrees C using x-ray diffraction. Rietveld refinement of the data suggests the material to be Pm [GRAPHICS] m (cubic) from 200 to 900 degrees C, P4/mmm (tetragonal) from 30 to 200 degrees C with phases similar to those of BaTiO3 [12]. Average grain size determined using scanning electron microscopy is 650nm. Measurements of dielectric properties from -50 to 120 degrees C and over a frequency range of 10Hz to 2MHz show a relatively flat dielectric constant that is electric-field tunable indicating that Ba(Ga,Ta)(0.05)Ti0.90O3 is a reasonable candidate for frequency agile components. C1 [Mion, Thomas; Tidrow, Steven C.] Univ Texas Pan Amer, Dept Phys & Geol, Edinburg, TX 78539 USA. [Potrepka, D. M.; Crowne, F. J.] US Army Res Lab, Adelphi, MD 20783 USA. [Tauber, A.] Geocenters Inc, US Army Res Lab, Washington, DC USA. RP Tidrow, SC (reprint author), Univ Texas Pan Amer, Dept Phys & Geol, Edinburg, TX 78539 USA. EM sctidrow@utpa.edu FU U.S. Army Research Laboratory; U.S. Army Research Office [W911NF-08-1-0353] FX This work was supported in part by the U.S. Army Research Laboratory and the U.S. Army Research Office through contract number W911NF-08-1-0353. NR 31 TC 1 Z9 1 U1 1 U2 10 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 0015-0193 EI 1563-5112 J9 FERROELECTRICS JI Ferroelectrics PD DEC 10 PY 2014 VL 473 IS 1 BP 13 EP 23 DI 10.1080/00150193.2014.974431 PG 11 WC Materials Science, Multidisciplinary; Physics, Condensed Matter SC Materials Science; Physics GA AW3MF UT WOS:000346190100002 ER PT J AU West, BJ AF West, Bruce J. TI A mathematics for medicine: The Network Effect SO FRONTIERS IN PHYSIOLOGY LA English DT Article DE physiologic networks; statistical extrema; complexity and disease; fractional calculus; complexity hypothesis ID HEART-RATE; NEURONAL AVALANCHES; FRACTIONAL DYNAMICS; STOCHASTIC-PROCESS; BRONCHIAL TREE; RANDOM-WALKS; FLUCTUATIONS; TURBULENCE; LONGEVITY; NOISE AB The theory of medicine and its complement systems biology are intended to explain the workings of the large number of mutually interdependent complex physiologic networks in the human body and to apply that understanding to maintaining the functions for which nature designed them. Therefore, when what had originally been made as a simplifying assumption or a working hypothesis becomes foundational to understanding the operation of physiologic networks it is in the best interests of science to replace or at least update that assumption. The replacement process requires, among other things, an evaluation of how the new hypothesis affects modern day understanding of medical science. This paper identifies linear dynamics and Normal statistics as being such arcane assumptions and explores some implications of their retirement. Specifically we explore replacing Normal with fractal statistics and examine how the latter are related to non-linear dynamics and chaos theory. The observed ubiquity of inverse power laws in physiology entails the need for a new calculus, one that describes the dynamics of fractional phenomena and captures the fractal properties of the statistics of physiological time series. We identify these properties as a necessary consequence of the complexity resulting from the network dynamics and refer to them collectively as The Network Effect. C1 Army Res Off, Math & Informat Sci Directorate, Res Triangle Pk, NC 27709 USA. RP West, BJ (reprint author), Army Res Off, Math & Informat Sci Directorate, 4300 S Miami Blvd, Res Triangle Pk, NC 27709 USA. EM bruce.j.west@att.net FU Army Research Office FX I would like to thank Drs. R. Magin, J. Milton, I. Osorio, and D. Sornette for reading an early version of the paper and making constructive suggestions for its improvements and M. Bologna for suggestions on the proof in Appendix 6.2. I, of course, retain full responsibility for the opinions and conclusions of the paper and thank the Army Research Office for support of this research. NR 97 TC 2 Z9 2 U1 1 U2 7 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1664-042X J9 FRONT PHYSIOL JI Front. Physiol. PD DEC 9 PY 2014 VL 5 AR 456 DI 10.3389/fphys.2014.00456 PG 17 WC Physiology SC Physiology GA AY8MJ UT WOS:000347807500001 PM 25538622 ER PT J AU Bergmeier, W Piatt, R Petrich, BG Monroe, D Mackman, N Getz, TM AF Bergmeier, Wolfgang Piatt, Raymond Petrich, Brian G. Monroe, Dougald Mackman, Nigel Getz, Todd M. TI Novel Mouse Hemostasis Model for Real-Time Determination of Bleeding Time and Hemostatic Plug Composition SO BLOOD LA English DT Meeting Abstract C1 [Bergmeier, Wolfgang; Piatt, Raymond; Monroe, Dougald; Mackman, Nigel] Univ N Carolina, Chapel Hill, NC USA. [Petrich, Brian G.] Emory Univ, Atlanta, GA 30322 USA. [Getz, Todd M.] US Army, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA SN 0006-4971 EI 1528-0020 J9 BLOOD JI Blood PD DEC 6 PY 2014 VL 124 IS 21 PG 3 WC Hematology SC Hematology GA CA9KQ UT WOS:000349242704181 ER PT J AU Darlington, DN Chen, J Wu, XW Keesee, J Liu, B Cap, AP AF Darlington, Daniel N. Chen, Jacob Wu, Xiaowu Keesee, Jeffery Liu, Bin Cap, Andrew P. TI Whole Blood Stored at 4 degrees C for 7 Days Is Equivalent to Fresh Whole Blood for Resuscitation of Severe Polytrauma SO BLOOD LA English DT Meeting Abstract C1 [Darlington, Daniel N.] Inst Surg Res, Jbsa Ft Sam Houston, TX USA. [Chen, Jacob; Wu, Xiaowu; Keesee, Jeffery; Liu, Bin; Cap, Andrew P.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA SN 0006-4971 EI 1528-0020 J9 BLOOD JI Blood PD DEC 6 PY 2014 VL 124 IS 21 PG 3 WC Hematology SC Hematology GA CA9KQ UT WOS:000349242700052 ER PT J AU Meledeo, MA Valenciana, MV Rodriguez, AC Cap, AP AF Meledeo, Michael A. Valenciana, Melanie V. Rodriguez, Armando C. Cap, Andrew P. TI Synergistic Anticoagulant Effect of Activated Protein C and Tissue Factor Pathway Inhibitor As a Mechanism for Acute Traumatic Coagulopathy SO BLOOD LA English DT Meeting Abstract C1 [Meledeo, Michael A.; Valenciana, Melanie V.; Rodriguez, Armando C.; Cap, Andrew P.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA SN 0006-4971 EI 1528-0020 J9 BLOOD JI Blood PD DEC 6 PY 2014 VL 124 IS 21 PG 3 WC Hematology SC Hematology GA CA9KQ UT WOS:000349242708142 ER PT J AU Pidcoke, HF Fedyk, CG Montgomery, RK Hinojosa-Laborde, C Convertino, VA Shade, RE Cap, AP AF Pidcoke, Heather F. Fedyk, Chriselda G. Montgomery, Robbie K. Hinojosa-Laborde, Carmen Convertino, Victor A. Shade, Robert E. Cap, Andrew P. TI Global Activation of Coagulation Is the Initiating Event of Acute Coagulopathy of Trauma As Modeled By Hemorrhage and Lower Body Negative Pressure in Baboons SO BLOOD LA English DT Meeting Abstract C1 [Pidcoke, Heather F.; Fedyk, Chriselda G.; Montgomery, Robbie K.; Hinojosa-Laborde, Carmen; Convertino, Victor A.; Cap, Andrew P.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX USA. [Shade, Robert E.] Texas Biomed Res Inst, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 4 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA SN 0006-4971 EI 1528-0020 J9 BLOOD JI Blood PD DEC 6 PY 2014 VL 124 IS 21 PG 3 WC Hematology SC Hematology GA CA9KQ UT WOS:000349242702042 ER PT J AU Wright, ZE Stewart, I Sosnov, J Pidcoke, HF Chriselda, F Kwan, H Heegard, K White, C Chung, K Cap, AP AF Wright, Zachary Edward Stewart, Ian Sosnov, Jonathan Pidcoke, Heather F. Chriselda, Fedyk Kwan, Hana Heegard, Kelly White, Christopher Chung, Kevin Cap, Andrew P. TI A Prospective Evaluation of Acute Traumatic Coagulopathy and Effects of Damage Control Resuscitation in Military Trauma Patients in Afghanistan SO BLOOD LA English DT Meeting Abstract C1 [Wright, Zachary Edward; Stewart, Ian; Sosnov, Jonathan; Chriselda, Fedyk; Kwan, Hana; Heegard, Kelly; White, Christopher; Chung, Kevin] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Pidcoke, Heather F.; Cap, Andrew P.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA SN 0006-4971 EI 1528-0020 J9 BLOOD JI Blood PD DEC 6 PY 2014 VL 124 IS 21 PG 3 WC Hematology SC Hematology GA CA9KQ UT WOS:000349242702191 ER PT J AU Bergmeier, W Paul, DS Stefanini, L Robledo, RF Chan, ER Getz, TM Piatt, R Boulaftali, Y Adams, MD Peters, LL AF Bergmeier, Wolfgang Paul, David S. Stefanini, Lucia Robledo, Raymond F. Chan, E. Ricky Getz, Todd M. Piatt, Raymond Boulaftali, Yacine Adams, Mark D. Peters, Luanne L. TI Premature Platelet Activation and Resistance to P2Y12 Inhibitors in Rasa3 Mutant Mice SO BLOOD LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Hematology CY DEC 06-09, 2014 CL San Francisco, CA SP Amer Soc Hematol C1 [Bergmeier, Wolfgang; Paul, David S.; Stefanini, Lucia; Piatt, Raymond; Boulaftali, Yacine] Univ N Carolina, Chapel Hill, NC USA. [Robledo, Raymond F.; Peters, Luanne L.] Jackson Lab, Bar Harbor, ME 04609 USA. [Chan, E. Ricky; Adams, Mark D.] Case Western Reserve Univ, Cleveland, OH 44106 USA. [Getz, Todd M.] US Army, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA SN 0006-4971 EI 1528-0020 J9 BLOOD JI Blood PD DEC 6 PY 2014 VL 124 IS 21 PG 3 WC Hematology SC Hematology GA CA9KX UT WOS:000349243502100 ER PT J AU Reddoch, KM Montgomery, RK Rodriguez, AC Meledeo, MA Pidcoke, HF Ramasubramanian, AK Cap, AP AF Reddoch, Kristin Michelle Montgomery, Robbie K. Rodriguez, Armando C. Meledeo, Michael A. Pidcoke, Heather F. Ramasubramanian, Anand K. Cap, Andrew P. TI Refrigerated Platelets Are Superior Compared to Standard-of-Care and Respond to Physiologic Control Mechanisms Under Microfluidic Flow Conditions SO BLOOD LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Hematology CY DEC 06-09, 2014 CL San Francisco, CA SP Amer Soc Hematol C1 [Reddoch, Kristin Michelle; Ramasubramanian, Anand K.] Univ Texas San Antonio, San Antonio, TX USA. [Montgomery, Robbie K.; Rodriguez, Armando C.; Meledeo, Michael A.; Pidcoke, Heather F.; Cap, Andrew P.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA SN 0006-4971 EI 1528-0020 J9 BLOOD JI Blood PD DEC 6 PY 2014 VL 124 IS 21 PG 3 WC Hematology SC Hematology GA CA9HU UT WOS:000349233806113 ER PT J AU Wu, XW Darlington, DN Cap, AP AF Wu, Xiaowu Darlington, Daniel N. Cap, Andrew P. TI Plasminogen and Plasmin Increase after Polytrauma Shifting the Thrombin/Plasmin Activity Ratio Toward Fibrinolysis SO BLOOD LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Hematology CY DEC 06-09, 2014 CL San Francisco, CA SP Amer Soc Hematol C1 [Wu, Xiaowu; Cap, Andrew P.] JBSA Ft Sam Houston, US Army Inst Surg Res, Houston, TX USA. [Darlington, Daniel N.] JBSA Ft Sam Houston, Inst Surg Res, Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA SN 0006-4971 EI 1528-0020 J9 BLOOD JI Blood PD DEC 6 PY 2014 VL 124 IS 21 PG 3 WC Hematology SC Hematology GA CA9HU UT WOS:000349233801033 ER PT J AU Guenon, S Ramirez, JG Basaran, AC Wampler, J Thiemens, M Taylor, S Schuller, IK AF Guenon, S. Ramirez, J. G. Basaran, Ali C. Wampler, J. Thiemens, M. Taylor, S. Schuller, Ivan K. TI Search for Superconductivity in Micrometeorites SO SCIENTIFIC REPORTS LA English DT Article ID TEMPERATURE SUPERCONDUCTIVITY; MICROWAVE-ABSORPTION; VERWEY TRANSITION; PRESOLAR STARDUST; COSMIC SPHERULES; ACCRETION RATE; MAGNETITE; METEORITES; FIELD AB We have developed a very sensitive, highly selective, non-destructive technique for screening inhomogeneous materials for the presence of superconductivity. This technique, based on phase sensitive detection of microwave absorption is capable of detecting 10(-12) cc of a superconductor embedded in a non-superconducting, non-magnetic matrix. For the first time, we apply this technique to the search for superconductivity in extraterrestrial samples. We tested approximately 65 micrometeorites collected from the water well at the Amundsen-Scott South pole station and compared their spectra with those of eight reference materials. None of these micrometeorites contained superconducting compounds, but we saw the Verwey transition of magnetite in our microwave system. This demonstrates that we are able to detect electro-magnetic phase transitions in extraterrestrial materials at cryogenic temperatures. C1 [Guenon, S.; Ramirez, J. G.; Basaran, Ali C.; Wampler, J.; Schuller, Ivan K.] Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USA. [Guenon, S.; Ramirez, J. G.; Basaran, Ali C.; Wampler, J.; Schuller, Ivan K.] Univ Calif San Diego, Ctr Adv Nanosci, La Jolla, CA 92093 USA. [Guenon, S.] Univ Tubingen, CQ Ctr Collect Quantum Phenomena & Their Applicat, LISA, Inst Phys, D-72076 Tubingen, Germany. [Thiemens, M.] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA. [Taylor, S.] Cold Reg Res & Engn Lab, Hanover, NH 03766 USA. RP Guenon, S (reprint author), Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USA. EM stefan.guenon@uni-tuebingen.de OI Ramirez, Juan Gabriel/0000-0001-8546-6966 FU Deutsche Forschungsgemeinschaft; Open Access Publishing Fund of Tuebingen University; AFOSR [FA9550-14-1-0202] FX We thank Dr. Andreas Morlock for pointing out the diversity of extraterrestrial materials and for the useful discussions at the beginning of our search for new superconductors. We thank Dr. H. Weinstock for his original idea on the search for superconductivity in unconventional materials. The micrometeorites were collected with support from the National Science Foundation. We acknowledge support by Deutsche Forschungsgemeinschaft and Open Access Publishing Fund of Tuebingen University. Research supported by AFOSR grant FA9550-14-1-0202. NR 40 TC 2 Z9 2 U1 0 U2 26 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD DEC 5 PY 2014 VL 4 AR 7333 DI 10.1038/srep07333 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AW4SF UT WOS:000346270100004 PM 25476841 ER PT J AU Kotan, H Darling, KA Scattergood, RO Koch, CC AF Kotan, Hasan Darling, Kris A. Scattergood, Ronald O. Koch, Carl C. TI Influence of Zr and nano-Y2O3 additions on thermal stability and improved hardness in mechanically alloyed Fe base ferritic alloys SO JOURNAL OF ALLOYS AND COMPOUNDS LA English DT Article DE Nanouystalline materials; Thermal stability; Grain growth; Hardness; ODS ID NANOCRYSTALLINE MATERIALS; GRAIN-BOUNDARY; DISPERSION; STEEL; GROWTH; ENERGY; SIZE AB The motivation of this work was driven to improve the thermal stability in systems where polymorphic transformations can result in an additional driving force, upsetting the expected thermodynamic stability. In this study, Fe92Ni8 alloys with Zr and nano-Y2O3 additions were produced by ball milling and then annealed at high temperatures. Emphasis was placed on understanding the effects of dispersed nano-Y2O3 particle additions and their effect on microstructural stability at and above the bcc-to-fcc transformation occurring at 700 degrees C in Fe-Ni systems. Results reveal that microstructural stability and hardness can be promoted by a combination of Zr and Y2O3 additions, that being mostly effective for stability before and after phase transition, respectively. The mechanical strength of these alloys is achieved by a unique microstructure comprised a ultra-fine grain Fe base matrix, which contains dispersions of both nano-scale in-situ formed Zr base intermetallics and ex-situ added Y2O3 secondary oxide phases. Both of these were found to be essential for a combination of high thermal stability and high mechanical strength properties. (C) 2014 Elsevier B.V. All rights reserved. C1 [Kotan, Hasan] Necmettin Erbakan Univ, Dept Met Engn & Mat Sci, TR-42140 Meram, Konya, Turkey. [Darling, Kris A.] US Army Res Lab, Weap & Mat Res Directorate, RDRL WMM F, Aberdeen Proving Ground, MD 21005 USA. [Scattergood, Ronald O.; Koch, Carl C.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. RP Kotan, H (reprint author), Necmettin Erbakan Univ, Dept Met Engn & Mat Sci, Dere Asiklar Mah Demet Sokak, TR-42140 Meram, Konya, Turkey. EM hkotan@konya.edu.tr FU NSF-DMR [1005677]; Necmettin Erbakan University FX The research reported in this paper was supported by NSF-DMR under Grant No. 1005677 and by Necmettin Erbakan University. NR 35 TC 4 Z9 4 U1 12 U2 73 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0925-8388 EI 1873-4669 J9 J ALLOY COMPD JI J. Alloy. Compd. PD DEC 5 PY 2014 VL 615 BP 1013 EP 1018 DI 10.1016/j.jallcom.2014.07.054 PG 6 WC Chemistry, Physical; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Chemistry; Materials Science; Metallurgy & Metallurgical Engineering GA AP7GL UT WOS:000342245700157 ER PT J AU Stromdahl, E Hamer, S Jenkins, S Sloan, L Williamson, P Foster, E Nadolny, R Elkins, C Vince, M Pritt, B AF Stromdahl, Ellen Hamer, Sarah Jenkins, Sarah Sloan, Lynne Williamson, Phillip Foster, Erik Nadolny, Robyn Elkins, Chad Vince, Mary Pritt, Bobbi TI Comparison of phenology and pathogen prevalence, including infection with the Ehrlichia muris-like (EML) agent, of Ixodes scapularis removed from soldiers in the midwestern and the northeastern United States over a 15 year period (1997-2012) SO PARASITES & VECTORS LA English DT Article DE Climate change; Co-infection; Ehrlichia muris-like agent; Engorgement; Ixodes scapularis; Pathogen prevalence; Phenology; Surveillance; Tick population establishment ID POLYMERASE-CHAIN-REACTION; BORRELIA-BURGDORFERI; LYME-DISEASE; ANAPLASMA-PHAGOCYTOPHILUM; DEER SURVEILLANCE; BABESIA-MICROTI; TICKS; WISCONSIN; IXODIDAE; ACARI AB Background: Since 1997, human-biting ticks submitted to the Department of Defense Human Tick Test Kit Program (HTTKP) of the US Army Public Health Command have been tested for pathogens by PCR. We noted differences in the phenology and infection prevalence among Ixodes scapularis ticks submitted from military installations in different geographic regions. The aim of this study was to characterize these observed differences, comparing the phenology and pathogen infection rates of I. scapularis submitted from soldiers at two sites in the upper Midwest ( Camp Ripley, MN, and Ft. McCoy, WI) and one site in the northeastern US (Ft. Indiantown Gap, PA). Methods: From 1997 through 2012, the HTTKP received 1,981 I. scapularis from the three installations and tested them for Anaplasma phagocytophilum, Babesia microti, Borrelia burgdorferi and the Ehrlichia muris-like (EML) agent using PCR; pathogen presence was confirmed via sequencing or amplification of a second gene target. Pathogen and co-infection prevalence, tick engorgement status, and phenology were compared among installations. Results: Greater rates of A. phagocytophilum and Ba. microti infections were detected in ticks submitted from installations in Minnesota than in Wisconsin or Pennsylvania, and the EML agent was only detected in ticks from Minnesota and Wisconsin. Midwestern ticks were also more likely to be co-infected than those from Pennsylvania. Both adult and nymphal ticks showed evidence of feeding on people, although nymphs were more often submitted engorged. Adult I. scapularis were received more frequently in June from Minnesota than from either of the other sites. Minnesota adult and nymphal peaks overlapped in June, and submissions of adults exceeded nymphs in that month. Conclusions: There were clear differences in I. scapularis phenology, pathogen prevalence and rates of co-infection among the three military installations. Seasonal and temperature differences between the three sites and length of time a population had been established in each region may contribute to the observed differences. The synchrony of adults and nymphs observed in the upper Midwest has implications for pathogen infection prevalence. The EML agent was only detected in Minnesota and Wisconsin, supporting the previous assertion that this pathogen is currently limited to the upper Midwest. C1 [Stromdahl, Ellen; Foster, Erik; Nadolny, Robyn; Elkins, Chad; Vince, Mary] US Army Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. [Hamer, Sarah] Texas A&M Univ, College Stn, TX USA. [Jenkins, Sarah; Sloan, Lynne; Pritt, Bobbi] Mayo Clin, Rochester, MN USA. [Williamson, Phillip] Univ N Texas, Hlth Sci Ctr, Ft Worth, TX USA. [Williamson, Phillip] Creat Testing Solut, Tempe, AZ USA. [Foster, Erik] Michigan Dept Community Hlth, Lansing, MI USA. [Nadolny, Robyn] Old Dominion Univ, Dept Biol Sci, Norfolk, VA 23529 USA. RP Stromdahl, E (reprint author), US Army Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. EM ellen.y.stromdahl.civ@mail.mil OI Pritt, Bobbi/0000-0003-0261-1326 NR 38 TC 7 Z9 7 U1 2 U2 76 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1756-3305 J9 PARASITE VECTOR JI Parasites Vectors PD DEC 4 PY 2014 VL 7 AR 553 DI 10.1186/s13071-014-0553-z PG 12 WC Parasitology SC Parasitology GA CA5JN UT WOS:000348944800001 PM 25465046 ER PT J AU Stallings, JD Ippolito, DL Rakesh, V Baer, CE Dennis, WE Helwig, BG Jackson, DA Leon, LR Lewis, JA Reifman, J AF Stallings, Jonathan D. Ippolito, Danielle L. Rakesh, Vineet Baer, Christine E. Dennis, William E. Helwig, Bryan G. Jackson, David A. Leon, Lisa R. Lewis, John A. Reifman, Jaques TI Patterns of gene expression associated with recovery and injury in heat-stressed rats SO BMC GENOMICS LA English DT Article DE Heat stress; Transcriptomics; Proteomics; Systems biology; Protein aggregation ID ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; ACTIVATING TRANSCRIPTION FACTOR-3; SHOCK PROTEINS; EXTRACELLULAR HEAT-SHOCK-PROTEIN-72; CROSS-TOLERANCE; MESSENGER-RNA; CELL-SURVIVAL; AUTOPHAGY; COMPLEX AB Background: The in vivo gene response associated with hyperthermia is poorly understood. Here, we perform a global, multiorgan characterization of the gene response to heat stress using an in vivo conscious rat model. Results: We heated rats until implanted thermal probes indicated a maximal core temperature of 41.8 degrees C (T-C,T- Max). We then compared transcriptomic profiles of liver, lung, kidney, and heart tissues harvested from groups of experimental animals at Tc, Max, 24 hours, and 48 hours after heat stress to time-matched controls kept at an ambient temperature. Cardiac histopathology at 48 hours supported persistent cardiac injury in three out of six animals. Microarray analysis identified 78 differentially expressed genes common to all four organs at Tc, Max. Self-organizing maps identified gene-specific signatures corresponding to protein-folding disorders in heat-stressed rats with histopathological evidence of cardiac injury at 48 hours. Quantitative proteomics analysis by iTRAQ (isobaric tag for relative and absolute quantitation) demonstrated that differential protein expression most closely matched the transcriptomic profile in heat-injured animals at 48 hours. Calculation of protein supersaturation scores supported an increased propensity of proteins to aggregate for proteins that were found to be changing in abundance at 24 hours and in animals with cardiac injury at 48 hours, suggesting a mechanistic association between protein misfolding and the heat-stress response. Conclusions: Pathway analyses at both the transcript and protein levels supported catastrophic deficits in energetics and cellular metabolism and activation of the unfolded protein response in heat-stressed rats with histopathological evidence of persistent heat injury, providing the basis for a systems-level physiological model of heat illness and recovery. C1 [Stallings, Jonathan D.; Dennis, William E.; Leon, Lisa R.] US Army Ctr Environm Hlth Res, Environm Hlth Program, Ft Detrick, MD 21702 USA. [Ippolito, Danielle L.] Oak Ridge Inst Sci & Educ, Ft Detrick, MD USA. [Rakesh, Vineet; Reifman, Jaques] US Army Med Res & Mat Command, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA. [Baer, Christine E.] Excet Inc, Ft Detrick, MD USA. [Helwig, Bryan G.; Leon, Lisa R.] US Army Res Inst Environm Med, Thermal Mt Med Div, Natick, MA USA. [Jackson, David A.] US Army Ctr Environm Hlth Res, Pulm Hlth Program, Ft Detrick, MD 21702 USA. RP Stallings, JD (reprint author), US Army Ctr Environm Hlth Res, Environm Hlth Program, Bldg 568 Doughten Dr, Ft Detrick, MD 21702 USA. EM jonathan.d.stallings.mil@mail.mil OI Stallings, Jonathan/0000-0002-6430-5888 FU Research Participation Program at the US Army Center for Environmental Health Research; Military Operational Medicine Research Program, US Army Medical Research and Materiel Command, Fort Detrick, Maryland; U.S. Department of Energy; MRMC; USACEHR FX We would like to thank Dr. Roy Vigneulle (Military Operational Medicine Research Program), CAPT Carroll D. Forcino (Director, Military Operational Medicine Research Program), COL Richard P. Duncan (former Commander, USACEHR), and COL Thomas C. Timmes (current Commander, USACEHR) for their programmatic support, encouragement, and insightful discussion. We also thank J. Ward, S. Dineen, M. Blaha, and R. Duran for technical support with the rat heat-stress experiments. We thank Gian G. Tartaglia and Michele Vendruscolo (University of Cambridge and Northwestern University) for batch calculation of the zagg and zaggSC used to calculate the sigmaf scores reported in this paper. This research was supported in part by an appointment to the Research Participation Program at the US Army Center for Environmental Health Research administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and MRMC and USACEHR. The research was supported by the Military Operational Medicine Research Program, US Army Medical Research and Materiel Command, Fort Detrick, Maryland. NR 95 TC 8 Z9 9 U1 1 U2 11 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2164 J9 BMC GENOMICS JI BMC Genomics PD DEC 3 PY 2014 VL 15 AR 1058 DI 10.1186/1471-2164-15-1058 PG 19 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA AW6OF UT WOS:000346388000001 PM 25471284 ER PT J AU Lambeth, RH Baranoski, MH AF Lambeth, Robert H. Baranoski, Myvan H. TI Oxidative Stabilization of Poly(norbornene) Polymers Prepared by Ring Opening Metathesis Polymerization SO JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY LA English DT Article DE stabilization; oxidation induction temperature; hindered phenol; ROMP ID THERMAL-OXIDATION; ABILITY; ROMP AB Polymers prepared by ring opening methathesis polymerization contain double bonds along the backbone and are susceptible to oxidation during high temperature processing or device operation. To overcome this, we report a simple method to improve the oxidative stability of ROMP based polymers by inclusion of a small percentage of monomer functionalized with a radical scavenger in the feedstock. The oxidation induction temperature was improved from 111 degrees C up to 262 degrees C when 8mol% of the functionalized comonomer was included in the feedstock. Modest improvements in the thermal decomposition temperature were also observed. C1 [Lambeth, Robert H.; Baranoski, Myvan H.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Lambeth, RH (reprint author), US Army, Res Lab, Weap & Mat Res Directorate, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. EM robert.h.lambeth2.civ@mail.mil NR 20 TC 1 Z9 1 U1 2 U2 19 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1060-1325 EI 1520-5738 J9 J MACROMOL SCI A JI J. Macromol. Sci. Part A-Pure Appl. Chem. PD DEC 2 PY 2014 VL 51 IS 12 BP 962 EP 965 DI 10.1080/10601325.2014.967085 PG 4 WC Polymer Science SC Polymer Science GA AT3WH UT WOS:000344863400003 ER PT J AU Lundy, JB AF Lundy, Jonathan B. TI A Primer on Wound Healing in Colorectal Surgery in the Age of Bioprosthetic Materials SO CLINICS IN COLON AND RECTAL SURGERY LA English DT Article DE wound healing; gastrointestinal; anastomosis; bioprosthetic mesh ID ACELLULAR DERMAL MATRIX; KERATINOCYTE GROWTH-FACTOR; VENTRAL HERNIA REPAIR; CROHNS-DISEASE; EXTRACELLULAR-MATRIX; PREOPERATIVE IRRADIATION; INTESTINAL ANASTOMOSES; COLONIC ANASTOMOSES; REDUCED EXPRESSION; COLLAGEN-SYNTHESIS AB Wound healing is a complex, dynamic process that is vital for closure of cutaneous injuries, restoration of abdominal wall integrity after laparotomy closure, and to prevent anastomotic dehiscence after bowel surgery. Derangements in healing have been described in multiple processes including diabetes mellitus, corticosteroid use, irradiation for malignancy, and inflammatory bowel disease. A thorough understanding of the process of healing is necessary for clinical decision making and knowledge of the current state of the science may lead future researchers in developing methods to enable our ability to modulate healing, ultimately improving outcomes. An exciting example of this ability is the use of bioprosthetic materials used for abdominal wall surgery (hernia repair/reconstruction). These bioprosthetic meshes are able to regenerate and remodel from an allograft or xenograft collagen matrix into site-specific tissue; ultimately being degraded and minimizing the risk of long-term complications seen with synthetic materials. The purpose of this article is to review healing as it relates to cutaneous and intestinal trauma and surgery, factors that impact wound healing, and wound healing as it pertains to bioprosthetic materials. C1 US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Lundy, JB (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM Jonathan.b.lundy2.mil@mail.mil NR 103 TC 1 Z9 1 U1 0 U2 0 PU THIEME MEDICAL PUBL INC PI NEW YORK PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA SN 1531-0043 EI 1530-9681 J9 CLIN COLON RECT SURG JI Clin. Colon Rectal Surg. PD DEC PY 2014 VL 27 IS 4 BP 125 EP 133 DI 10.1055/s-0034-1394086 PG 9 WC Gastroenterology & Hepatology; Surgery SC Gastroenterology & Hepatology; Surgery GA CL3XH UT WOS:000356884800003 PM 25435821 ER PT J AU Brooker, MJW AF Brooker, Major John W. TI IMPROVING UNIFORM CODE OF MILITARY JUSTICE REFORM SO MILITARY LAW REVIEW LA English DT Article C1 US Army, Washington, DC 20310 USA. RP Brooker, MJW (reprint author), US Army, Washington, DC 20310 USA. NR 237 TC 0 Z9 0 U1 3 U2 3 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2014 VL 222 BP 1 EP 128 PG 128 WC Law SC Government & Law GA CI2ON UT WOS:000354587000001 ER PT J AU Babb, MNH AF Babb, Major Nathaniel H. TI DON'T FORGET THE FAR EAST: A MODERN LESSON FROM THE CHINESE PROSECUTION OF JAPANESE WAR CRIMINALS AFTER WORLD WAR II SO MILITARY LAW REVIEW LA English DT Article ID JUSTICE C1 US Army, Washington, DC 20310 USA. RP Babb, MNH (reprint author), US Army, Washington, DC 20310 USA. NR 70 TC 0 Z9 0 U1 1 U2 1 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2014 VL 222 BP 129 EP 155 PG 27 WC Law SC Government & Law GA CI2ON UT WOS:000354587000002 ER PT J AU Hamaguchi, MCAM AF Hamaguchi, Major Cara-Ann M. TI A PRECARIOUS BALANCE: MANAGING STIGMA, CONFIDENTIALITY, AND COMMAND AWARENESS IN THE MENTAL HEALTH ARENA SO MILITARY LAW REVIEW LA English DT Article C1 US Army, Washington, DC 20310 USA. RP Hamaguchi, MCAM (reprint author), US Army, Washington, DC 20310 USA. NR 77 TC 0 Z9 0 U1 1 U2 2 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2014 VL 222 BP 156 EP 210 PG 55 WC Law SC Government & Law GA CI2ON UT WOS:000354587000003 ER PT J AU Valente, JJ LeGrande, CL Johnson, VM Fischer, RA AF Valente, Jonathon J. LeGrande, Christa L. Johnson, Vincent M. Fischer, Richard A. TI A Method for Improving the Reliability of Sound Broadcast Systems Used in Ecological Research and Management SO WILDLIFE SOCIETY BULLETIN LA English DT Article DE bird song; CD player; momentary action pushbutton switch; play button depression mechanism; sound broadcast system ID BREEDING HABITAT SELECTION; GAP-CROSSING DECISIONS; TEMPERATE RAIN-FOREST; CONSPECIFIC-ATTRACTION; DETECTION PROBABILITY; SITE SELECTION; SOCIAL INFORMATION; UNDERSTORY BIRDS; SONGBIRDS; CALLS AB Automated sound broadcast systems have been used to address a variety of ecological questions, and show great potential as a management tool. Such systems need to be reliable because treatments are often applied in the absence of a human observer and system failure can cause methodological ambiguity. During the breeding seasons of 2012 and 2013, we used a sound broadcast system previously described by Farrell and Campomizzi (2011) in an experiment evaluating the use of post-breeding song in forest-bird habitat selection in southern Indiana, USA. This system incorporates a portable compact disc (CD) player where the play button is permanently depressed using manual compression so that when a timer connects an electrical current to the unit, the CD player automatically starts. Despite exhaustive efforts to find a reliable way to manually compress the play button on numerous CD player models, play button failure was the most significant source of broadcast system failure (88%) in 2012. We attempted to resolve this problem in 2013 by removing the need for manual compression and soldering the play button contact poles on each CD players' integrated circuit boards. Though we did experience broadcast system failures during < 5% of treatment periods in 2013, none of those were attributable to play button failure. By removing all possibility of failure from manual play button compression we improved our system reliability. Thus, soldering theCD player play button on such broadcast systems represents a methodological improvement that can be used by researchers and managers interested in sound broadcast. (C) 2014 The Wildlife Society. C1 [Valente, Jonathon J.] Oregon State Univ, Dept Forest Ecosyst & Soc, Corvallis, OR 97331 USA. [LeGrande, Christa L.] SUNY Coll Environm Sci & Forestry, Dept Environm & Forest Biol, Syracuse, NY 13210 USA. [Johnson, Vincent M.] SUNY Agr & Tech Coll Cobleskill, Fisheries Wildlife & Environm Studies Dept, Cobleskill, NY 12043 USA. [Fischer, Richard A.] US Army, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Valente, JJ (reprint author), Oregon State Univ, Dept Forest Ecosyst & Soc, Corvallis, OR 97331 USA. EM jonathon.j.valente@gmail.com NR 28 TC 0 Z9 0 U1 0 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1938-5463 J9 WILDLIFE SOC B JI Wildl. Soc. Bull. PD DEC PY 2014 VL 38 IS 4 BP 827 EP 830 DI 10.1002/wsb.468 PG 4 WC Biodiversity Conservation SC Biodiversity & Conservation GA CD9RA UT WOS:000351434500022 ER PT J AU Stone, JK DeShazer, D Brett, PJ Burtnick, MN AF Stone, Joshua K. DeShazer, David Brett, Paul J. Burtnick, Mary N. TI Melioidosis: molecular aspects of pathogenesis SO EXPERT REVIEW OF ANTI-INFECTIVE THERAPY LA English DT Review DE Burkholderia pseudomallei; capsule; facultative intracellular pathogen; lipopolysaccharide; melioidosis; pathogenesis; secretion systems; virulence factors ID III SECRETION SYSTEM; ACTIN-BASED MOTILITY; BURKHOLDERIA-PSEUDOMALLEI LIPOPOLYSACCHARIDE; INFECTED MOUSE MACROPHAGES; INTRACELLULAR LIFE-CYCLE; REGULATORY PROTEIN ALPHA; MOTIF-CONTAINING PROTEIN; QUORUM-SENSING SYSTEM; GIANT-CELL FORMATION; IN-VIVO VIRULENCE AB Burkholderia pseudomallei is a gram-negative bacterium that causes melioidosis, a multifaceted disease that is highly endemic in southeast Asia and northern Australia. This facultative intracellular pathogen possesses a large genome that encodes a wide array of virulence factors that promote survival in vivo by manipulating host cell processes and disarming elements of the host immune system. Antigens and systems that play key roles in B. pseudomallei virulence include capsular polysaccharide, lipopolysaccharide, adhesins, specialized secretion systems, actin-based motility and various secreted factors. This review provides an overview of the current and steadily expanding knowledge regarding the molecular mechanisms used by this organism to survive within a host and their contribution to the pathogenesis of melioidosis. C1 [Stone, Joshua K.; Brett, Paul J.; Burtnick, Mary N.] Univ S Alabama, Dept Microbiol & Immunol, Mobile, AL 36688 USA. [DeShazer, David] US Army, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. RP Burtnick, MN (reprint author), Univ S Alabama, Dept Microbiol & Immunol, 610 Clin Dr, Mobile, AL 36688 USA. EM mburtnick@southalabama.edu FU NIH-National Institute of Allergy and Infectious Diseases; DOD-Defense Threat Reduction Agency; NIH-NIAID [AI065359, AIO91783] FX The authors are funded by the NIH-National Institute of Allergy and Infectious Diseases and DOD-Defense Threat Reduction Agency. MN Burtnick and PJ Brett declare NIH-NIAID award numbers AI065359 and AIO91783. D Deshazer declares DTRA/JSTO-CBD proposal number CBCALL12-LSI-2-0070. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. NR 123 TC 7 Z9 7 U1 5 U2 23 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1478-7210 EI 1744-8336 J9 EXPERT REV ANTI-INFE JI Expert Rev. Anti-Infect. Ther. PD DEC PY 2014 VL 12 IS 12 BP 1487 EP 1499 DI 10.1586/14787210.2014.970634 PG 13 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA CB6XV UT WOS:000349771200007 PM 25312349 ER PT J AU Lynn, DC Lesemann, RK Detro, JF Seery, JM AF Lynn, David C. Lesemann, Rebecca K. Detro, John F. Seery, Jason M. TI Employment of the "Role 2-Plus": Lessons Learned in a Time of High OPTEMPO SO MILITARY MEDICINE LA English DT Editorial Material AB From 2009 to 2014, the medical units at Fort Bragg, North Carolina, gained extensive experience in the nondoctrinal employment of the Forward Surgical Team (FST) combined with an Area Support Medical Company (ASMC) or Brigade Support Medical Company (BSMC). The setup and execution of the so-called "Role 2-plus" offers multiple operational and clinical advantages over solitary employment, but also presents some significant logistical challenges without proper planning. At the time of authorship, current literature describes this entity, (1) but information or guidance as to the actual employment of the Role 2-plus (including web-based outlets such as Center for Army Lessons Learned) is almost nonexistent. (1-6) Former commanders of these units would like to share and document some of the lessons learned during a time of exceptionally high operational tempo (OPTEMPO). C1 [Lynn, David C.] Womack Army Med Ctr, Dept Surg, Ft Bragg, NC 28310 USA. [Lesemann, Rebecca K.] Texas A&M Univ, Bush Sch Govt & Publ Serv, College Stn, TX 77843 USA. [Detro, John F.] USDA, XVIII Airborne Corps, Off Corps Surg, Ft Bragg, NC 28310 USA. [Seery, Jason M.] Jackson Mem Hosp, US Army Trauma Training Ctr, Ryder Trauma Ctr, Miami, FL 33136 USA. RP Lynn, DC (reprint author), Womack Army Med Ctr, Dept Surg, 2817 Reilly Rd, Ft Bragg, NC 28310 USA. NR 16 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD DEC PY 2014 VL 179 IS 12 BP 1412 EP 1418 DI 10.7205/MILMED-D-14-00099 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA CA7MB UT WOS:000349100300003 PM 25469961 ER PT J AU Bornemann, P Bornemann, G AF Bornemann, Paul Bornemann, Gina TI Military Family Physicians' Perceptions of a Pocket Point-of-Care Ultrasound Device in Clinical Practice SO MILITARY MEDICINE LA English DT Article AB Point-of-care ultrasonography with a pocket ultrasound device, General Electric Medical Systems Vscan (Milwaukee, Wisconsin), has been shown to be effective and easy to learn. However, no studies to date have evaluated its use in the military primary care setting where its portability and value in bedside diagnosis would be especially beneficial. We tested the feasibility of the Vscan in the day-to-day care of patients by family physicians in their clinic, inpatient wards, and its potential for use in the military-deployed setting. Participants were trained and credentialed in the use of the point-of-care ultrasonography. Then, participants were provided with a pocket ultrasound device to use in their normal day-to-day practice. Additionally, participants completed surveys and provided ratings on their perceptions regarding the use of the device. According to the survey analysis, participants found the devices to be easy to use, valuable in discerning a diagnosis, and were not prohibitively time consuming. Moreover, patients were perceived by the participants to have been satisfied with the use of the device. Overall, participants had high satisfaction with the Vscan and perceived that the device would be highly valuable in the military-deployed setting. C1 [Bornemann, Paul; Bornemann, Gina] Tripler Army Med Ctr, Dept Family Med, Honolulu, HI 96859 USA. RP Bornemann, P (reprint author), Tripler Army Med Ctr, Dept Family Med, 1 Jarrett White Rd, Honolulu, HI 96859 USA. FU Department of Family Medicine at Tripler Army Medical Center; U.S. Army Medical Research and Material Command, Fort Detrick, MD (DHP 6.7 Grant) [20013008] FX We thank the Department of Family Medicine at Tripler Army Medical Center for supporting this study. We thank Dr. Matt Dawson, Dr. Mike Mallin of The Ultrasound Podcast, and Dr. Will Scruggs for providing the initial 16-hour training session. Financial support was received by the U.S. Army Medical Research and Material Command, Fort Detrick, MD (DHP 6.7 Grant Number 20013008). NR 5 TC 3 Z9 3 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD DEC PY 2014 VL 179 IS 12 BP 1474 EP 1477 DI 10.7205/MILMED-D-14-00241 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA CA7MB UT WOS:000349100300013 PM 25469971 ER PT J AU Sulsky, SI Karlsson, LH Bulzacchelli, MT Luippold, RS Rodriguez-Monguio, R Bulathsinhala, L Hill, OT AF Sulsky, Sandra I. Karlsson, Lee H. Bulzacchelli, Maria T. Luippold, Rose S. Rodriguez-Monguio, Rosa Bulathsinhala, Lakmini Hill, Owen T. TI Methodological Challenges of Using US Army Administrative Data to Identify a Cohort of Basic Combat Trainees and Descriptive Analysis of Trends in Characteristics That Are Potential Risk Factors for Training-Related Injury SO MILITARY MEDICINE LA English DT Article ID YOUNG MEN; MILITARY; PREVENTION; OVERWEIGHT; OBESITY; STRESS; RATES; WOMEN AB Objectives: Training-related injury is a threat to military health and readiness. Prevalence of potential risk factors for training-related injury can change with U. S. Army recruitment goals and may influence basic combat training (BCT) injury rates. This article describes challenges of using administrative data to identify a trainee cohort and describes demographic and training characteristics across the five BCT locations. Methods: Data from the Total Army Injury and Health Outcomes Database were used to identify a U. S. Army-wide cohort of first-time trainees from January 1, 2002 to September 30, 2007 and describe its characteristics. Results: The cohort includes 368,102 first-time trainees. The annual number starting BCT increased from 52,187 in 2002 to 68,808 in 2004. The proportion of males increased from 81.57% in 2003 to 83.84% in 2007. Mean (SD) age increased from 20.67 (3.55) years in 2002 to 20.94 (3.65) years in 2007. Mean (SD) body mass index increased from 24.53 (3.56) kg/m(2) in 2002 to 24.94 (3.84) kg/m(2) in 2006. Other characteristics fluctuated by year, including proportions of race/ethnicity, accession waivers, and confirmed graduates. Conclusions: Fluctuations in trainee characteristics warrant further analysis of potential influence on BCT injury rates. For research uses, careful acquisition of administrative data is needed. C1 [Sulsky, Sandra I.; Karlsson, Lee H.; Luippold, Rose S.] ENVIRON Int Corp, Amherst, MA 01002 USA. [Bulzacchelli, Maria T.; Rodriguez-Monguio, Rosa] Univ Massachusetts, Dept Publ Hlth, Amherst, MA 01002 USA. [Bulathsinhala, Lakmini; Hill, Owen T.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA. RP Sulsky, SI (reprint author), ENVIRON Int Corp, 28 Amity St,Suite 2A, Amherst, MA 01002 USA. FU U.S. Army Medical Research Materiel Command [W911QY-10-C-0194]; U.S. Army Research Institute of Environmental Medicine FX The authors thank the data providers, as well as DMDC data expert Mr. Richard Moreno for assistance interpreting relationships among dates and variables in the various data sources and Dr. Colleen Barkley for supplying ATRRS data to verify the annual number of BCT recruits at Fort Jackson, SC. We also thank Ms. Cynthia Lemire for assistance preparing the manuscript. This work was supported by the U.S. Army Medical Research Materiel Command under contract no. W911QY-10-C-0194 in collaboration with the U.S. Army Research Institute of Environmental Medicine. NR 19 TC 1 Z9 1 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD DEC PY 2014 VL 179 IS 12 BP 1487 EP 1496 DI 10.7205/MILMED-D-14-00007 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA CA7MB UT WOS:000349100300015 PM 25469973 ER PT J AU Cutter, L Clarke, T AF Cutter, Laura Clarke, Tim, Jr. TI Anesthesia Advances During the Civil War SO MILITARY MEDICINE LA English DT Editorial Material C1 [Cutter, Laura; Clarke, Tim, Jr.] US Army Med Res & Mat Command, Natl Museum Hlth & Med, Silver Spring, MD 20910 USA. RP Cutter, L (reprint author), US Army Med Res & Mat Command, Natl Museum Hlth & Med, 2500 Linden Lane, Silver Spring, MD 20910 USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD DEC PY 2014 VL 179 IS 12 BP 1503 EP 1503 DI 10.7205/MILMED-D-14-00344 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA CA7MB UT WOS:000349100300017 PM 25469975 ER PT J AU Teyhen, DS Aldag, M Centola, D Edinborough, E Ghannadian, JD Haught, A Jackson, T Kinn, J Kunkler, KJ Levine, B Martindale, VE Neal, D Snyder, LB Styn, MA Thorndike, F Trabosh, V Parramore, DJ AF Teyhen, Deydre S. Aldag, Matt Centola, Damon Edinborough, Elton Ghannadian, Jason D. Haught, Andrea Jackson, Theresa Kinn, Julie Kunkler, Kevin J. Levine, Betty Martindale, Valerie E. Neal, David Snyder, Leslie B. Styn, Mindi A. Thorndike, Frances Trabosh, Valerie Parramore, David J. TI Incentives to Create and Sustain Healthy Behaviors: Technology Solutions and Research Needs SO MILITARY MEDICINE LA English DT Editorial Material ID SELF-DETERMINATION THEORY; RANDOMIZED CONTROLLED-TRIAL; PHYSICAL-ACTIVITY INTERVENTION; WEIGHT-LOSS MAINTENANCE; MASS-MEDIA CAMPAIGNS; SOCIAL MEDIA; INTRINSIC MOTIVATION; INTERNET INTERVENTIONS; COLLECTIVE DYNAMICS; EXTRINSIC REWARDS AB Health-related technology, its relevance, and its availability are rapidly evolving. Technology offers great potential to minimize and/or mitigate barriers associated with achieving optimal health, performance, and readiness. In support of the U.S. Army Surgeon General's vision for a "System for Health" and its Performance Triad initiative, the U.S. Army Telemedicine and Advanced Technology Research Center hosted a workshop in April 2013 titled "Incentives to Create and Sustain Change for Health." Members of government and academia participated to identify and define the opportunities, gain clarity in leading practices and research gaps, and articulate the characteristics of future technology solutions to create and sustain real change in the health of individuals, the Army, and the nation. The key factors discussed included (1) public health messaging, (2) changing health habits and the environmental influence on health, (3) goal setting and tracking, (4) the role of incentives in behavior change intervention, and (5) the role of peer and social networks in change. This report summarizes the recommendations on how technology solutions could be employed to leverage evidence-based best practices and identifies gaps in research where further investigation is needed. C1 [Teyhen, Deydre S.; Edinborough, Elton; Ghannadian, Jason D.; Haught, Andrea; Kunkler, Kevin J.; Levine, Betty; Trabosh, Valerie] US Army Med Res & Mat Command, Ft Detrick, MD 21702 USA. [Aldag, Matt] Booz Allen Hamilton, Rockville, MD 20852 USA. [Centola, Damon] Univ Penn, Annenberg Sch, Network Sci Inst, Philadelphia, PA 19104 USA. [Jackson, Theresa] Army Inst Publ Hlth, Aberdeen Proving Ground, MD 21010 USA. [Kinn, Julie] Joint Base Lewis McChord, Natl Ctr Telehlth & Technol, Washington, DC 20431 USA. [Martindale, Valerie E.] Booz Allen Hamilton, Dayton, OH 45420 USA. [Neal, David] Empirica Res, Miami, FL 33133 USA. [Snyder, Leslie B.] Univ Connecticut, Ctr Hlth Intervent & Prevent, Dept Commun, Storrs, CT 06269 USA. [Styn, Mindi A.] Univ Pittsburgh, Sch Nursing, Dept Hlth & Community Syst, Pittsburgh, PA 15261 USA. [Styn, Mindi A.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15261 USA. [Thorndike, Frances] Univ Virginia Hlth Syst, Dept Psychiat & Neurobehav Sci, Charlottesville, VA 22908 USA. [Parramore, David J.] Off Surg Gen, Falls Church, VA 22042 USA. RP Teyhen, DS (reprint author), US Army Med Res & Mat Command, Ft Detrick, MD 21702 USA. NR 124 TC 1 Z9 1 U1 2 U2 16 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD DEC PY 2014 VL 179 IS 12 BP 1419 EP 1431 DI 10.7205/MILMED-D-14-00111 PG 13 WC Medicine, General & Internal SC General & Internal Medicine GA CA7MB UT WOS:000349100300004 PM 25469962 ER PT J AU Williams, RM Ray, LE Lever, JH Burzynski, AM AF Williams, Rebecca M. Ray, Laura E. Lever, James H. Burzynski, Amy M. TI Crevasse Detection in Ice Sheets Using Ground Penetrating Radar and Machine Learning SO IEEE JOURNAL OF SELECTED TOPICS IN APPLIED EARTH OBSERVATIONS AND REMOTE SENSING LA English DT Article DE Geophysical signal processing; ground penetrating radar (GPR); robotic sensing systems ID HIDDEN MARKOV-MODELS; LANDMINE DETECTION; SPEECH RECOGNITION; GPR; IMAGES AB This paper presents methods to automatically classify ground penetrating radar (GPR) images of crevasses on ice sheets. We use a combination of support vector machines (SVMs) and hidden Markov models (HMMs) with down sampling, a preprocessing step that is unbiased and suitable for real-time analysis and detection. We perform modified cross-validation experiments with 129 examples of Greenland GPR imagery from 2012, collected by a lightweight robot towing a GPR. In order to minimize false positives, an HMM classifier is trained to prescreen the data and mark locations in the GPR files to evaluate with an SVM, and we evaluate the classification results with a similar modified cross-validation technique. The combined HMM-SVM method retains all of the correct classifications by the SVM, and reduces the false positive rate to 0.0007. This method also reduces the computational burden in classifying GPR traces because the SVM is evaluated only on select prescreened traces. Our experiments demonstrate the promise, robustness, and reliability of real-time crevasse detection and classification with robotic GPR surveys. C1 [Williams, Rebecca M.] Dartmouth Coll, Hanover, NH 03755 USA. [Ray, Laura E.] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. [Lever, James H.; Burzynski, Amy M.] US Army Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Williams, RM (reprint author), Johns Hopkins Univ, Appl Phys Lab, Johns Hopkins Rd, Laurel, MD 20723 USA. EM rebecca.williams@jhuapl.edu; lray@dartmouth.edu; james.lever@erdc.dren.mil; amy.burzynski@unco.edu FU National Science Foundation [NSF-ART0806157, NSF-DGE0801490] FX This work was supported by the National Science Foundation under Grant NSF-ART0806157 and Grant NSF-DGE0801490. NR 27 TC 1 Z9 1 U1 3 U2 10 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1939-1404 EI 2151-1535 J9 IEEE J-STARS JI IEEE J. Sel. Top. Appl. Earth Observ. Remote Sens. PD DEC PY 2014 VL 7 IS 12 SI SI BP 4836 EP 4848 DI 10.1109/JSTARS.2014.2332872 PG 13 WC Engineering, Electrical & Electronic; Geography, Physical; Remote Sensing; Imaging Science & Photographic Technology SC Engineering; Physical Geography; Remote Sensing; Imaging Science & Photographic Technology GA AZ7BA UT WOS:000348372000020 ER PT J AU Trope, RL Hantover, LL AF Trope, Roland L. Hantover, Lixian Loong TI In the Wake of Cyber Damage: Significant Decisions in Cybersecurity 2013-2014 SO BUSINESS LAWYER LA English DT Article C1 [Trope, Roland L.] New York City Off Trope & Schramm LLP, New York, NY 10017 USA. [Trope, Roland L.] US Mil Acad, Dept Law, West Point, NY USA. [Hantover, Lixian Loong] Wilson Sonsini Goodrich & Rosati, Palo Alto Off, Palo Alto, CA USA. RP Trope, RL (reprint author), New York City Off Trope & Schramm LLP, New York, NY 10017 USA. EM rltrope@tropelaw.com; lhantover@wsgr.com NR 5 TC 1 Z9 1 U1 0 U2 6 PU AMER BAR ASSOC, ADMINISTRATIVE LAW & REGULATORY PRACTICE SECTION PI CHICAGO PA 321 N CLARK ST, CHICAGO, IL 60610 USA SN 0007-6899 EI 2164-1838 J9 BUS LAWYER JI Bus. Lawyer PD WIN PY 2014 VL 70 IS 1 BP 223 EP 230 PG 8 WC Law SC Government & Law GA AZ5KT UT WOS:000348260700009 ER PT J AU Newman, T Farrell, SL Richter-Menge, J Connor, LN Kurtz, NT Elder, BC McAdoo, D AF Newman, Thomas Farrell, Sinead L. Richter-Menge, Jacqueline Connor, Laurence N. Kurtz, Nathan T. Elder, Bruce C. McAdoo, David TI Assessment of radar-derived snow depth over Arctic sea ice SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article DE snow; sea ice; remote sensing; instruments and techniques; wavelet transform ID THICKNESS; MISSION; LASER AB Knowledge of contemporaneous snow depth on Arctic sea ice is important both to constrain the regional climatology and to improve the accuracy of satellite altimeter estimates of sea ice thickness. We assess new data available from the NASA Operation IceBridge snow radar instrument and derive snow depth estimates across the western Arctic ice pack using a novel methodology based on wavelet techniques that define the primary reflecting surfaces within the snow pack. We assign uncertainty to the snow depth estimates based upon both the radar system parameters and sea ice topographic variability. The accuracy of the airborne snow depth estimates are examined via comparison with coincident measurements gathered in situ across a range of ice types in the Beaufort Sea. We discuss the effect of surface morphology on the derivation, and consequently the accuracy, of airborne snow depth estimates. We find that snow depths derived from the airborne snow radar using the wavelet-based technique are accurate to 1 cm over level ice. Over rougher surfaces including multiyear and ridged ice, the radar system is impacted by ice surface morphology. Across basin scales, we find the snow-radar-derived snow depth on first-year ice is at least approximate to 60% of the value reported in the snow climatology for the Beaufort Sea, Canada Basin, and parts of the central Arctic, since these regions were previously dominated by multiyear ice during the measurement period of the climatology. Snow on multiyear ice is more consistent with the climatology. C1 [Newman, Thomas; Farrell, Sinead L.; McAdoo, David] Univ Maryland, Earth Syst Sci Interdisciplinary Ctr, College Pk, MD 20742 USA. [Newman, Thomas; Farrell, Sinead L.; Connor, Laurence N.; McAdoo, David] NOAA, Lab Satellite Altimetry, Satellite Oceanog & Climatol Div, Ctr Weather & Climate Predict, College Pk, MD USA. [Richter-Menge, Jacqueline; Elder, Bruce C.] US Army Corps Engn, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH USA. [Kurtz, Nathan T.] NASA, Goddard Space Flight Ctr, Hydrospher & Biospher Sci Lab, Greenbelt, MD 20771 USA. RP Newman, T (reprint author), Univ Maryland, Earth Syst Sci Interdisciplinary Ctr, College Pk, MD 20742 USA. EM tnewman3@umd.edu RI Connor, Laurence/E-7930-2011; McAdoo, Dave/F-5612-2010; Farrell, Sinead/F-5586-2010 OI Connor, Laurence/0000-0002-5276-6257; McAdoo, Dave/0000-0002-7533-5564; Farrell, Sinead/0000-0003-3222-2751 FU ONR Arctic grants [N000141210512, N0001412MP20150]; NOAA Ocean Remote Sensing Program FX Data used for the results of this paper are found at the National Snow and Ice Data Center (NSIDC, nsidc.org). IceBridge data utilized in this study are archived at the NSIDC: the IceBridge ATM Level-1B Elevation and Return Strength (ILATM1B) data set is available at http://nsidc.org/data/ilatm1b.html, the DMS L1B Geolocated and Orthorectified Images (IODMS1B) data set is available at http://nsidc.org/data/iodms1b.html, the NASA IceBridge Snow Radar Level-1B Geolocated Radar Echo Strength Profiles (IRSNO1B) data set is available at http://nsidc.org/data/irsno1b.html, and the IceBridge Sea Ice Freeboard, Snow Depth, and Thickness (IDCSI2) data set is available at http://nsidc.org/data/idcsi2.html. This work was supported by ONR Arctic grants N000141210512 and N0001412MP20150 and by the NOAA Ocean Remote Sensing Program. The authors thank Dr. L. Miller and two anonymous reviewers for their comments which helped to improve the text. The authors thank the IceBridge Instrument Teams, Science Team, and Project Science Office, as well as the aircraft support crew, for their diligent efforts in gathering and processing the OIB data. We acknowledge the significant work done by the CReSIS faculty, staff, and students in the design, development, operation, and data processing for the snow radar system. The authors thank the U.S. Army Cold Regions Research and Engineering Laboratory for collecting the in situ data. The authors thank the Naval Research Laboratory for their logistical support, including members of the field team. The authors thank the Arctic Submarine Laboratory for providing the ice camp that served as the base of operations for the in situ observation team and assisted in the coordination of the aircraft over flights. Data used in this paper were acquired by NASAs Operation IceBridge Project. The contents are solely the opinions of the authors and do not constitute a statement of policy, decision, or position on behalf of NOAA or the U.S. Government. NR 41 TC 7 Z9 7 U1 3 U2 17 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-9275 EI 2169-9291 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD DEC PY 2014 VL 119 IS 12 BP 8578 EP 8602 DI 10.1002/2014JC010284 PG 25 WC Oceanography SC Oceanography GA AZ8GI UT WOS:000348452800022 ER PT J AU Perovich, DK Jones, KF AF Perovich, Donald K. Jones, Kathleen F. TI The seasonal evolution of sea ice floe size distribution SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article DE sea ice; floe size distribution; floe breaking ID ARCTIC-OCEAN; SUMMER; COVER; SHEBA AB The Arctic sea ice cover undergoes large changes over an annual cycle. In winter and spring, the ice cover consists of large, snow-covered plate-like ice floes, with very little open water. By the end of summer, the snow cover is gone and the large floes have broken into a complex mosaic of smaller, rounded floes surrounded by a lace of open water. This evolution strongly affects the distribution and fate of the solar radiation deposited in the ice-ocean system and consequently the heat budget of the ice cover. In particular, increased floe perimeter can result in enhanced lateral melting. We attempt to quantify the floe evolution process through the concept of a floe size distribution that is modified by lateral melting and floe breaking. A time series of aerial photographic surveys made during the SHEBA field experiment is analyzed to determine evolution of the floe size distribution from spring through summer. Based on earlier studies, we assume the floe size cumulative distribution could be represented by a power law D-, where D is the floe diameter. The exponent as well as the number density of floes N-tot are estimated from measurements of total ice area and perimeter. As summer progressed, there was an increase in as the size distribution shifted toward smaller floes and the number of floes increased. Lateral melting causes the distribution to deviate from a power law for small floe sizes. C1 [Perovich, Donald K.; Jones, Kathleen F.] ERDC CRREL, Hanover, NH 03755 USA. [Perovich, Donald K.] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. RP Perovich, DK (reprint author), ERDC CRREL, Hanover, NH 03755 USA. EM Donald.k.perovich@usace.army.mil FU Office of Naval Research; CRREL Microgrant program FX This work was funded by the Office of Naval Research and the CRREL Microgrant program. We thank the Editor, Andrey Proshutinsky, and three anonymous reviewers for their valuable insights and suggestions. The data and images used in this paper are available from the lead author. NR 20 TC 7 Z9 8 U1 2 U2 7 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-9275 EI 2169-9291 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD DEC PY 2014 VL 119 IS 12 BP 8767 EP 8777 DI 10.1002/2014JC010136 PG 11 WC Oceanography SC Oceanography GA AZ8GI UT WOS:000348452800031 ER PT J AU Freese, EC Acitelli, RM Gist, NH Cureton, KJ Evans, EM O'Connor, PJ AF Freese, Eric C. Acitelli, Rachelle M. Gist, Nicholas H. Cureton, Kirk J. Evans, Ellen M. O'Connor, Patrick J. TI Effect of Six Weeks of Sprint Interval Training on Mood and Perceived Health in Women at Risk for Metabolic Syndrome SO JOURNAL OF SPORT & EXERCISE PSYCHOLOGY LA English DT Article DE exercise psychology; exercise training; health behavior ID QUALITY-OF-LIFE; POSTPRANDIAL LIPEMIA; PHYSICAL-ACTIVITY; EXERCISE; ADAPTATIONS; SYMPTOMS; CAPACITY; MUSCLE; PERFORMANCE; DEPRESSION AB The purpose of this investigation was to determine whether 6 weeks of sprint interval training (SIT) is associated with changes in mood and perceived health in women at risk for developing metabolic syndrome (MetS). Physically inactive women (30-65 years) were randomized to 6 weeks of nutrition meetings and SIT (n = 23; 3 bouts/week of 4-8 30-s cycle sprints with 4-mM recovery) or a nonexercise control condition (CON; n = 24). Before and after the 6-week intervention, perceived health status and mood were assessed. Clinically relevant increases in role-physical scores (ES = 0.64) and vitality (ES = 0.52) were found after 6 weeks of SIT compared with a nonexercise control group. For middle-aged women at risk for MetS, it is concluded that high-intensity, low-volume SIT (1) increases feelings of vitality and perceptions of having fewer physical limitations and (2) does not induce mood disturbances as occurs with high-volume, high-intensity training. C1 [Freese, Eric C.; Acitelli, Rachelle M.; Gist, Nicholas H.; Cureton, Kirk J.; Evans, Ellen M.; O'Connor, Patrick J.] Univ Georgia, Dept Kinesiol, Athens, GA 30602 USA. [Gist, Nicholas H.] US Mil Acad, Dept Phys Educ, West Point, NY 10996 USA. RP Freese, EC (reprint author), Univ Georgia, Dept Kinesiol, Athens, GA 30602 USA. EM efreese2@gmail.com FU Egg Nutrition Center FX The authors thank Jeremy Dean, Sasha McBurse, and Chad Straight for their assistance with the exercise training and Catherine Beck and Whitni McConnell for their weight maintenance and dietary guidance. In addition, the authors thank the undergraduate research assistants in the Department of Kinesiology, especially Sara Dover and Rachel Butler, for their assistance with testing, data entry, and supervising exercise training sessions. This randomized clinical trial was supported by the Egg Nutrition Center. The authors declare no conflicts of interest. NR 31 TC 4 Z9 4 U1 2 U2 13 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 0895-2779 EI 1543-2904 J9 J SPORT EXERCISE PSY JI J. Sport Exerc. Psychol. PD DEC PY 2014 VL 36 IS 6 BP 610 EP 618 DI 10.1123/jsep.2014-0083 PG 9 WC Hospitality, Leisure, Sport & Tourism; Psychology, Applied; Psychology; Sport Sciences SC Social Sciences - Other Topics; Psychology; Sport Sciences GA AZ8UY UT WOS:000348491000006 PM 25602143 ER PT J AU Enslen, JA AF Enslen, Joshua Alma TI Between Tijuca and Mars Maddening Intertextualities in Clarice Lispector's "A imitacao da rosa" SO LUSO-BRAZILIAN REVIEW LA English DT Article C1 US Mil Acad, West Point, NY USA. RP Enslen, JA (reprint author), US Mil Acad, West Point, NY USA. NR 11 TC 0 Z9 0 U1 0 U2 1 PU UNIV WISCONSIN PRESS PI MADISON PA JOURNAL DIVISION, 1930 MONROE ST, 3RD FL, MADISON, WI 53711 USA SN 0024-7413 EI 1548-9957 J9 LUSO-BRAZ REV JI Luso-Braz. Rev. PD DEC 1 PY 2014 VL 51 IS 2 BP 68 EP 79 PG 12 WC Humanities, Multidisciplinary SC Arts & Humanities - Other Topics GA AZ4OK UT WOS:000348201700004 ER PT J AU Esposito, ER Wilken, JM AF Esposito, Elizabeth Russell Wilken, Jason M. TI Biomechanical risk factors for knee osteoarthritis when using passive and powered ankle-foot prostheses SO CLINICAL BIOMECHANICS LA English DT Article DE Loading; Gait; Transtibial; Amputation; BiOM ID TRANS-TIBIAL AMPUTATION; LOWER-LIMB AMPUTEES; FRONTAL PLANE; GAIT; WALKING; JOINT; HIP; MOMENTS; LOAD; LEG AB Background: Gait compensations following transtibial amputation negatively affect sound limb loading and increase the risk of knee osteoarthritis. Push-off assistance provided by new powered prostheses may decrease the demands on the sound limb. However, their effects in a young population in the early stages of prosthetic use are still unknown. The purpose of this study was to compare limb loading between 1. passive and powered ankle-foot prostheses, 2. sound and amputated limbs, and 3. individuals with amputations in the relatively early stages of prosthetic use and controls. Methods: Ten young, active individuals with unilateral transtibial amputation and 10 controls underwent biomechanical gait analysis at three speeds. The peak external knee flexor and adductor moments, adductor moment's angular impulse, peak vertical ground reaction force and loading rate were calculated. Repeated measures ANOVAs compared between limbs, prostheses, and groups. Findings: The powered prosthesis did not decrease the sound limb's peak adduction moment or its impulse, but did decrease the external flexor moment, peak vertical force and loading rate as speed increased. The powered prosthesis decreased the loading rate from controls. The sound limb did not display a significantly greater risk for knee osteoarthritis than the intact limb or than controls in either device. Interpretation: In the early stages of prosthetic use, young individuals with transtibial amputation display few biomechanical risk factors for knee osteoarthritis development. However, a powered ankle-foot prosthesis still offers some benefits and may be used prophylactically to mitigate potential increases of these variables with continued prosthetic use over time. C1 Brooke Army Med Ctr, Ctr Intrepid, Ft Sam Houston, TX 78234 USA. RP Esposito, ER (reprint author), Ctr Intrepid, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM erussell.kin@gmail.com OI Wilken, Jason/0000-0002-5556-7667 FU Center for Rehabilitation Sciences Research (CRSR); Department of Physical Medicine and Rehabilitation; Uniformed Services University of Health Sciences, Bethesda, MD; U.S. Army Telemedicine & Advanced Technology Research Center (TATRC) [W81K00-09-P-1129] FX Support provided by the Center for Rehabilitation Sciences Research (CRSR), Department of Physical Medicine and Rehabilitation, Uniformed Services University of Health Sciences, Bethesda, MD and U.S. Army Telemedicine & Advanced Technology Research Center (TATRC) (W81K00-09-P-1129). NR 56 TC 7 Z9 7 U1 4 U2 18 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0268-0033 EI 1879-1271 J9 CLIN BIOMECH JI Clin. Biomech. PD DEC PY 2014 VL 29 IS 10 BP 1186 EP 1192 PG 7 WC Engineering, Biomedical; Orthopedics; Sport Sciences SC Engineering; Orthopedics; Sport Sciences GA AY5CW UT WOS:000347591800016 ER PT J AU Koppenhaver, SL Hebert, JJ Kawchuk, GN Childs, JD Teyhen, DS Croy, T Fritz, JM AF Koppenhaver, Shane L. Hebert, Jeffrey J. Kawchuk, Greg N. Childs, John D. Teyhen, Deydre S. Croy, Theodore Fritz, Julie M. TI Criterion validity of manual assessment of spinal stiffness SO MANUAL THERAPY LA English DT Article DE Stiffness; Low back pain; Validity; Manual assessment ID LOW-BACK-PAIN; RANDOMIZED CONTROLLED-TRIAL; CLINICAL-PREDICTION RULE; LUMBAR SPINE; INTERVERTEBRAL MOTION; SEGMENTAL MOBILITY; NECK PAIN; RELIABILITY; PALPATION; MANIPULATION AB Assessment of spinal stiffness is widely used by manual therapy practitioners as a part of clinical diagnosis and treatment selection. Although studies have commonly found poor reliability of such procedures, conflicting evidence suggests that assessment of spinal stiffness may help predict response to specific treatments. The current study evaluated the criterion validity of manual assessments of spinal stiffness by comparing them to indentation measurements in patients with low back pain (LBP). As part of a standard examination, an experienced clinician assessed passive accessory spinal stiffness of the L3 vertebrae using posterior to anterior (PA) force on the spinous process of L3 in 50 subjects (54% female, mean (SD) age = 33.0 (12.8) years, BMI = 27.0 (6.0) kg/m(2)) with LBP. A criterion measure of spinal stiffness was performed using mechanized indentation by a blinded second examiner. Results indicated that manual assessments were uncorrelated to criterion measures of stiffness (spearman rho = 0.06, p = 0.67). Similarly, sensitivity and specificity estimates of judgments of hypomobility were low (0.20-0.45) and likelihood ratios were generally not statistically significant. Sensitivity and specificity of judgments of hypermobility were not calculated due to limited prevalence. Additional analysis found that BMI explained 32% of the variance in the criterion measure of stiffness, yet failed to improve the relationship between assessments. Additional studies should investigate whether manual assessment of stiffness relates to other clinical and biomechanical constructs, such as symptom reproduction, angular rotation, quality of motion, or end feel. Published by Elsevier Ltd. C1 [Koppenhaver, Shane L.; Teyhen, Deydre S.; Croy, Theodore] Baylor Univ, US Army, Doctoral Program Phys Therapy, San Antonio, TX USA. [Fritz, Julie M.] Univ Utah, Coll Hlth, Salt Lake City, UT USA. [Fritz, Julie M.] Intermt Hlth Care, Salt Lake City, UT USA. [Hebert, Jeffrey J.] Murdoch Univ, Sch Psychol & Exercise Sci, Perth, WA, Australia. [Kawchuk, Greg N.] Univ Alberta, Dept Phys Therapy, Edmonton, AB T6G 2M7, Canada. [Childs, John D.] Keesler Air Force Base, Dept Phys Therapy MSGS SGCUY, Med Grp 81st, Biloxi, MS USA. RP Koppenhaver, SL (reprint author), 204 Tuttle Rd, San Antonio, TX USA. EM shanekoppenhaver@mac.com OI Croy, Theodore/0000-0002-3053-8974; Hebert, Jeffrey/0000-0002-6959-325X FU National Institutes of Health, National Center for Complementary and Alternative Medicine [R21 AT004221] FX This study was supported by the National Institutes of Health, National Center for Complementary and Alternative Medicine (R21 AT004221). This study was approved by the Institutional Review Boards of the University of Utah. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Departments of the Army or Defense. NR 36 TC 2 Z9 2 U1 1 U2 5 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1356-689X EI 1532-2769 J9 MANUAL THER JI Man. Ther. PD DEC PY 2014 VL 19 IS 6 BP 589 EP 594 DI 10.1016/j.math.2014.06.001 PG 6 WC Rehabilitation SC Rehabilitation GA AY7DH UT WOS:000347721000013 PM 24965495 ER PT J AU Baker, MD Simkins, S Spokas, LA Veneman, PLM Xing, BS AF Baker, M. D. Simkins, S. Spokas, L. A. Veneman, P. L. M. Xing, B. S. TI Comparison of Phosphorus Sorption by Light-Weight Aggregates Produced in the United States SO PEDOSPHERE LA English DT Article DE binding affinity; constructed wetlands; equilibrium P concentration; media; P sorption capacity ID POTENTIAL FILTER MEDIA; CONSTRUCTED WETLANDS; ETHANOL-PRODUCTION; REMOVAL; WATER AB In this study, phosphorus (P) sorption of thirteen light-weight aggregates (LWAs) from USA was compared during batch equilibrium experiments in order to identify those materials which had the highest P sorption capacity for further study. Seven different levels of sorption activity were observed, which were broadly grouped into three categories high performing, middle performing, and low performing aggregates. Chemical analysis of Ca, Al, Fe, and Mg was used to describe the differences between LWAs. There was a significant correlation between cation (especially Al, Ca, Fe, and Mg) content and P sorbed. Langmuir isotherms were used to describe P sorption maximum and binding affinity for four of the top five performing LWAs, Universal, Stalite "D", Stalite "Mix", and TXI. The fifth aggregate, Lehigh, exhibited more complex sorption, and was better described by the Freundlich isotherm. Universal had a mean P sorption at the highest concentration of 824 mg kg(-1), well above its calculated sorption maximum (702 mg kg(-1)), and also had the highest binding affinity (1.1 L mg(-1)). This experiment suggests that the top performing LWA (Universal) may perform poorly in column and field studies due to observed precipitates, which could degrade constructed wetland performance. Other LWAs may exhibit superior field performance due to their high calculated sorption maxima. In general, these results highlight the importance of batch experiments as a first step in identifying materials suitable for column and field experiments. C1 [Baker, M. D.; Simkins, S.; Spokas, L. A.; Veneman, P. L. M.; Xing, B. S.] Univ Massachusetts, Stockbridge Sch Agr, Amherst, MA 01003 USA. [Baker, M. D.] US Army, Ft Hood, TX 76544 USA. RP Spokas, LA (reprint author), Univ Massachusetts, Stockbridge Sch Agr, Amherst, MA 01003 USA. EM mspokas@psis.umass.edu FU Soil Characterization Laboratory, University of Masachusetts, Amherst, MA, USA FX Supported by the Soil Characterization Laboratory, University of Masachusetts, Amherst, MA, USA. NR 23 TC 0 Z9 0 U1 2 U2 7 PU SCIENCE PRESS PI BEIJING PA 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA SN 1002-0160 EI 2210-5107 J9 PEDOSPHERE JI Pedosphere PD DEC PY 2014 VL 24 IS 6 BP 808 EP 816 PG 9 WC Soil Science SC Agriculture GA AY7XN UT WOS:000347769300012 ER PT J AU Willens, S Cox, DM Braue, EH Myers, TM Wegner, MD AF Willens, Scott Cox, David M. Braue, Ernest H. Myers, Todd M. Wegner, Matthew D. TI Novel Technique for Retroperitoneal Implantation of Telemetry Transmitters for Physiologic Monitoring in Gottingen Minipigs (Sus scrofa domesticus) SO COMPARATIVE MEDICINE LA English DT Article ID NERVE AGENT VX; PERCUTANEOUS-ABSORPTION; RHESUS MACAQUES; ECG LEAD; SKIN; MODEL; PIG; PLACEMENT; TOXICITY; EXPOSURE AB Telemetric monitoring of physiologic parameters in animal models is a critical component of chemical and biologic agent studies. The long-term collection of neurobehavioral and other physiologic data can require larger telemetry devices. Furthermore, such devices must be implanted in a location that is safe, well-tolerated, and functional. Gottingen minipigs (Sus scrota domesticus) present an ideal large animal model for chemical agent studies due to their relatively small size, characterized health status, and ease of training and handling. We report an effective approach to implanting a novel device to measure transthoracic impedance to approximate respiratory tidal volume and rate in Suidae. We tested the approach using 24 male Gottingen minipigs. A ventral midline abdominal incision extending from the umbilicus to the prepuce was followed by a paramedian incision of the parietal peritoneum and dorsal blunt dissection to create a retroperitoneal pocket. The device was anchored inside the pocket to the internal abdominal musculature with 3-0 nonabsorbable suture, biopotential leads were routed through the abdominal musculature, and the pocket was closed with 3-0 absorbable suture. Paired biopotential leads were anchored intermuscularly at the level of the seventh rib midway between spine and sternum bilaterally to provide surrogate data for respiratory function. Postoperative recovery and gross pathology findings at necropsy were used to assess safety and refine the surgical procedure. Results demonstrated that this procedure permitted effective monitoring of complex physiologic data, including transthoracic impedance, without negatively affecting the health and behavior of the animals. C1 [Willens, Scott; Braue, Ernest H.; Myers, Todd M.] US Army, Med Res Inst Chem Def, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA. [Wegner, Matthew D.] US Army, Med Res Inst Chem Def, Res Support Div, Aberdeen Proving Ground, MD 21010 USA. [Cox, David M.] Walter Reed Army Inst Res, Vet Serv Program, Silver Spring, MD USA. RP Willens, S (reprint author), US Army, Med Res Inst Chem Def, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA. EM scott.willensanil@mail.mil FU Defense Threat Reduction Agency-Joint Science and Technology Office, Medical ST Division FX We acknowledge the surgical expertise and assistance of LTC Chad D Foster, Dipl ACLAM, and MAJ Eric D Lee, as well as the surgical and telemetry training provided by Megan Swaab Fine, MS. Photographs were taken by Ms Stephanie R Froberg. This research was supported by the Defense Threat Reduction Agency-Joint Science and Technology Office, Medical S&T Division. The views expressed in this report are those of the authors and do not reflect the official policy of the Department of Army, Department of Defense, or the US Government. NR 36 TC 1 Z9 1 U1 0 U2 3 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1532-0820 J9 COMPARATIVE MED JI Comparative Med. PD DEC PY 2014 VL 64 IS 6 BP 464 EP 470 PG 7 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA AX4IE UT WOS:000346895800006 PM 25527027 ER PT J AU Garrison, AR Giomarelli, BG Lear-Rooney, CM Saucedo, CJ Yellayi, S Krumpe, LRH Rose, M Paragas, J Bray, M Olinger, GG McMahon, JB Huggins, J O'Keefe, BR AF Garrison, Aura R. Giomarelli, Barbara G. Lear-Rooney, Calli M. Saucedo, Carrie J. Yellayi, Srikanth Krumpe, Lauren R. H. Rose, Maura Paragas, Jason Bray, Mike Olinger, Gene G., Jr. McMahon, James B. Huggins, John O'Keefe, Barry R. TI The cyanobacterial lectin scytovirin displays potent in vitro and in vivo activity against Zaire Ebola virus SO ANTIVIRAL RESEARCH LA English DT Article DE Ebola; Scytovirin; Lectin; Natural product; Cyanobacteria ID ANTI-HIV PROTEIN; CYANOVIRIN-N; INACTIVATING PROTEIN; FILOVIRUS INFECTION; SCYTONEMA-VARIUM; GLYCOPROTEIN; ENTRY; GRIFFITHSIN; INHIBITOR; BINDS AB The cyanobacterial lectin scytovirin (SVN) binds with high affinity to mannose-rich oligosaccharides on the envelope glycoprotein (GP) of a number of viruses, blocking entry into target cells. In this study, we assessed the ability of SVN to bind to the envelope GP of Zaire Ebola virus (ZEBOV) and inhibit its replication. SVN interacted specifically with the protein's mucin-rich domain. In cell culture, it inhibited ZEBOV replication with a 50% virus-inhibitory concentration (EC50) of 50 nM, and was also active against the Angola strain of the related Marburg virus (MARV), with a similar EC50. Injected subcutaneously in mice, SVN reached a peak plasma level of 100 nm in 45 min, but was cleared within 4 h. When ZEBOV-infected mice were given 30 mg/kg/day of SVN by subcutaneous injection every 6 h, beginning the day before virus challenge, 9 of 10 animals survived the infection, while all infected, untreated mice died. When treatment was begun one hour or one day after challenge, 70-90% of mice survived. Quantitation of infectious virus and viral RNA in samples of serum, liver and spleen collected on days 2 and 5 postinfection showed a trend toward lower titers in treated than control mice, with a significant decrease in liver titers on day 2. Our findings provide further evidence of the potential of natural lectins as therapeutic agents for viral infections. Published by Elsevier B.V. C1 [Garrison, Aura R.; Lear-Rooney, Calli M.; Paragas, Jason; Bray, Mike; Olinger, Gene G., Jr.; Huggins, John] US Army, Med Res Inst Infect Dis, Dept Viral Therapeut, Div Virol, Ft Detrick, MD 21702 USA. [Giomarelli, Barbara G.; Saucedo, Carrie J.; Krumpe, Lauren R. H.; Rose, Maura; McMahon, James B.; O'Keefe, Barry R.] NCI, Ctr Canc Res, Mol Targets Lab, NIH,Frederick Natl Lab Canc Res, Ft Detrick, MD 21702 USA. [Saucedo, Carrie J.; Krumpe, Lauren R. H.] Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, Basic Sci Program, Frederick, MD 21702 USA. [Yellayi, Srikanth] NIAID, Off Chief Scientist, Integrated Res Facil, Div Clin Res, Frederick, MD USA. [Bray, Mike] NIAID, Div Clin Res, NIH, Bethesda, MD 20892 USA. RP O'Keefe, BR (reprint author), NCI, Mol Targets Lab, Bldg 562,Rm 201, Ft Detrick, MD 21702 USA. EM okeefeba@mail.nih.gov FU Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research and the NIAID Trans-NIH/FDA Biodefense Grant Program; Frederick National Laboratory for Cancer Research, National Institutes of Health [HHSN261200800001E] FX This research was supported by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research and the NIAID Trans-NIH/FDA Biodefense Grant Program. This project has been funded in whole or in part with federal funds from the Frederick National Laboratory for Cancer Research, National Institutes of Health, under contract HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. Opinions, interpretations, conclusions, and recommendations are those of the author and are not necessarily endorsed by the U.S. Army. NR 24 TC 11 Z9 13 U1 3 U2 26 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 EI 1872-9096 J9 ANTIVIR RES JI Antiviral Res. PD DEC PY 2014 VL 112 BP 1 EP 7 DI 10.1016/j.antiviral.2014.09.012 PG 7 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA AX5CE UT WOS:000346943900001 PM 25265598 ER PT J AU Shekh-Ahmad, T Mawasi, H McDonough, JH Finnell, RH Wlodarczyk, BJ Yavin, E Bialer, M AF Shekh-Ahmad, Tawfeeq Mawasi, Hafiz McDonough, John H. Finnell, Richard H. Wlodarczyk, Bogdan J. Yavin, Eylon Bialer, Meir TI Enantioselective pharmacodynamic and pharmacokinetic analysis of two chiral CNS-active carbamate derivatives of valproic acid SO EPILEPSIA LA English DT Article DE New antiepileptic drugs; Valproic acid; Carbamates derivatives of VPA; CNS drugs; Enantioselective pharmacokinetic; Pharmacodynamic analysis ID SOMAN-INDUCED SEIZURES; ANTIEPILEPTIC DRUGS; STATUS EPILEPTICUS; ANTICONVULSANT ACTIVITY; UNIQUE ACTIVITY; EPILEPSY; DISCOVERY; 2ND-GENERATION; CARBAMAZEPINE; VALNOCTAMIDE AB Objective2-Ethyl-3-methylbutyl-carbamate (EMC) and 2-isopropylpentyl-carbamate (IPC) are among the most potent anticonvulsant carbamate derivatives of valproic acid. EMC and IPC are chiral compounds. Consequently, the aim of the current study was to comparatively evaluate the pharmacokinetic (PK) and pharmacodynamic (PD anticonvulsant activity) profile of EMC and IPC individual enantiomers. MethodsThe anticonvulsant activity of EMC and IPC individual enantiomers was evaluated in several anticonvulsant rodent models including maximal electroshock (MES), 6Hz psychomotor, subcutaneous (pentylenetetrazole) (scMet), and the pilocarpine-induced and soman-induced status epilepticus (SE). The PK-PD relationship of EMC and IPC individual enantiomers was evaluated following intraperitoneal administration (50mg/kg) to rats. Induction of neural tube defects (NTDs) was evaluated in a mouse strain that was highly susceptible to teratogen-induced NTDs. ResultsIn mice and rats, (2S)-EMC exhibited anticonvulsant activity similar to that of racemic EMC in the MES and scMet tests, whereas in the 6Hz test, racemic EMC was more potent than its two individual enantiomers. Racemic EMC exhibited a potent activity in the soman-induced SE model when administered 5 and 20min after seizure onset with median effective dose (ED50) values of 33 and 48mg/kg, respectively. (2R)-IPC and (2S)-IPC exhibited ED50 values similar to those of racemic IPC in the mouse and rat MES and scMet models. (2R)-IPC had similar ED50 values on the 6Hz tests. Racemic IPC had an ED50 value of 107mg/kg in the pilocarpine-induced SE model when given 30min after seizure onset. Racemic EMC and IPC and their enantiomers had similar clearance (3.8-5.5L/h/kg) and short half-life (<1h). EMC and its enantiomers did not cause NTDs at doses 3-10 times higher than their anticonvulsant ED50 values. SignificanceEMC and IPC did not exhibit enantioselective PK, a fact that may contribute to their nonenantioselective activity in any of the anticonvulsant models. The nonsignificant difference between racemic EMC and racemic IPC and their enantiomers, suggests that their wide spectrum of anticonvulsant activity is likely to be caused by multiple mechanisms of action. C1 [Shekh-Ahmad, Tawfeeq; Mawasi, Hafiz; Yavin, Eylon; Bialer, Meir] Hebrew Univ Jerusalem, Sch Pharm, Inst Drug Res, Fac Med, IL-91120 Jerusalem, Israel. [McDonough, John H.] US Army Med Res Inst Chem Def, Pharmacol Branch, Div Res, Aberdeen Proving Ground, MD USA. [Finnell, Richard H.; Wlodarczyk, Bogdan J.] Univ Texas Austin, Dell Pediat Res Inst, Dept Nutr Sci, Austin, TX 78712 USA. [Bialer, Meir] Hebrew Univ Jerusalem, David R Bloom Ctr Pharm, IL-91120 Jerusalem, Israel. RP Bialer, M (reprint author), Hebrew Univ Jerusalem, Sch Pharm, Inst Drug Res, Fac Med, POB 12065, IL-91120 Jerusalem, Israel. EM bialer@md.huji.ac.il OI Wlodarczyk, Bogdan J./0000-0001-5249-5832 FU Bial; CTS Chemicals; Desitin; Janssen-Cilag; Johnson Johnson; Medgenics; Rekah; Sepracor; Teva; UCB Pharma; Upsher-Smith FX Dr. Meir Bialer has received in the last 3 years speakers or consultancy fees from Bial, CTS Chemicals, Desitin, Janssen-Cilag, Johnson & Johnson, Medgenics, Rekah, Sepracor, Teva, UCB Pharma, and Upsher-Smith. Dr. Bialer has been involved in the design and development of new antiepileptics and CNS drugs as well as new formulations of existing drugs. None of the other authors has any conflict of interest to disclose. We, the authors, confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines. NR 39 TC 1 Z9 1 U1 1 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0013-9580 EI 1528-1167 J9 EPILEPSIA JI Epilepsia PD DEC PY 2014 VL 55 IS 12 BP 1944 EP 1952 DI 10.1111/epi.12857 PG 9 WC Clinical Neurology SC Neurosciences & Neurology GA AX5OE UT WOS:000346975200014 PM 25442425 ER PT J AU Dankova, V Balonova, L Straskova, A Spidlova, P Putzova, D Kijek, T Bozue, J Cote, C Mou, S Worsham, P Szotakova, B Cerveny, L Stulik, J AF Dankova, Vera Balonova, Lucie Straskova, Adela Spidlova, Petra Putzova, Daniela Kijek, Todd Bozue, Joel Cote, Christopher Mou, Sherry Worsham, Patricia Szotakova, Barbora Cerveny, Lukas Stulik, Jiri TI Characterization of Tetratricopeptide Repeat-Like Proteins in Francisella tularensis and Identification of a Novel Locus Required for Virulence SO INFECTION AND IMMUNITY LA English DT Article ID LIVE VACCINE STRAIN; ESCHERICHIA-COLI; SIGNAL-TRANSDUCTION; MEMBRANE-PROTEINS; TULAREMIA; MACROPHAGES; SYSTEM; GENES; REPLICATION; MODULATION AB Francisella tularensis is a highly infectious bacterium that causes the potentially lethal disease tularemia. This extremely virulent bacterium is able to replicate in the cytosolic compartments of infected macrophages. To invade macrophages and to cope with their intracellular environment, Francisella requires multiple virulence factors, which are still being identified. Proteins containing tetratricopeptide repeat (TPR)-like domains seem to be promising targets to investigate, since these proteins have been reported to be directly involved in virulence-associated functions of bacterial pathogens. Here, we studied the role of the FTS_0201, FTS_0778, and FTS_1680 genes, which encode putative TPR-like proteins in Francisella tularensis subsp. holarctica FSC200. Mutants defective in protein expression were prepared by TargeTron insertion mutagenesis. We found that the locus FTS_1680 and its ortholog FTT_0166c in the highly virulent Francisella tularensis type A strain SchuS4 are required for proper intracellular replication, full virulence in mice, and heat stress tolerance. Additionally, the FTS_1680-encoded protein was identified as a membrane-associated protein required for full cytopathogenicity in macrophages. Our study thus identifies FTS_1680/FTT_0166c as a new virulence factor in Francisella tularensis. C1 [Dankova, Vera; Szotakova, Barbora] Charles Univ Prague, Fac Pharm Hradec Kralove, Dept Biochem Sci, Hradec Kralove, Czech Republic. [Dankova, Vera; Balonova, Lucie; Straskova, Adela; Spidlova, Petra; Putzova, Daniela; Stulik, Jiri] Univ Def, Fac Mil Hlth Sci, Inst Mol Pathol, Hradec Kralove, Czech Republic. [Kijek, Todd; Bozue, Joel; Cote, Christopher; Mou, Sherry; Worsham, Patricia] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Cerveny, Lukas] Charles Univ Prague, Fac Pharm Hradec Kralove, Dept Pharmacol & Toxicol, Hradec Kralove, Czech Republic. RP Cerveny, L (reprint author), Charles Univ Prague, Fac Pharm Hradec Kralove, Dept Pharmacol & Toxicol, Hradec Kralove, Czech Republic. EM cervenyl@faf.cuni.cz FU Grant Agency of Charles University, Prague, Czech Republic [160/50/15011, SVV260065, D-CZ-10-00001, CB3387 PA D-CZ-11-0001] FX This work was supported by grants 160/50/15011 from the Grant Agency of Charles University, Prague, Czech Republic (SVV260065, DTRA project D-CZ-10-00001, and DTRA project CB3387 PA D-CZ-11-0001). NR 47 TC 1 Z9 1 U1 2 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 EI 1098-5522 J9 INFECT IMMUN JI Infect. Immun. PD DEC PY 2014 VL 82 IS 12 BP 5035 EP 5048 DI 10.1128/IAI.01620-14 PG 14 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AX5HZ UT WOS:000346958400014 PM 25245806 ER PT J AU Jelacic, TM Chabot, DJ Bozue, JA Tobery, SA West, MW Moody, K Yang, D Oppenheim, JJ Friedlander, AM AF Jelacic, Tanya M. Chabot, Donald J. Bozue, Joel A. Tobery, Steven A. West, Michael W. Moody, Krishna Yang, De Oppenheim, Joost J. Friedlander, Arthur M. TI Exposure to Bacillus anthracis Capsule Results in Suppression of Human Monocyte-Derived Dendritic Cells (vol 82, pg 3405, 2014) SO INFECTION AND IMMUNITY LA English DT Correction C1 [Jelacic, Tanya M.; Chabot, Donald J.; Bozue, Joel A.; Tobery, Steven A.; West, Michael W.; Friedlander, Arthur M.] US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Yang, De; Oppenheim, Joost J.] Frederick Natl Lab Canc Res, Mol Immunoregulat Lab, Frederick, MD USA. [Moody, Krishna] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA. RP Jelacic, TM (reprint author), US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 EI 1098-5522 J9 INFECT IMMUN JI Infect. Immun. PD DEC PY 2014 VL 82 IS 12 BP 5347 EP 5347 DI 10.1128/IAI.02665-14 PG 1 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AX5HZ UT WOS:000346958400043 ER PT J AU Yet, B Perkins, ZB Rasmussen, TE Tai, NRM Marsh, DWR AF Yet, Barbaros Perkins, Zane B. Rasmussen, Todd E. Tai, Nigel R. M. Marsh, D. William R. TI Combining data and meta-analysis to build Bayesian networks for clinical decision support SO JOURNAL OF BIOMEDICAL INFORMATICS LA English DT Article DE Clinical decision support; Bayesian networks; Evidence-based medicine; Evidence synthesis; Meta-analysis ID MODEL; REGRESSION; INFERENCE; ALGORITHM; SCORES AB Complex clinical decisions require the decision maker to evaluate multiple factors that may interact with each other. Many clinical studies, however, report 'univariate' relations between a single factor and outcome. Such univariate statistics are often insufficient to provide useful support for complex clinical decisions even when they are pooled using meta-analysis. More useful decision support could be provided by evidence-based models that take the interaction between factors into account. In this paper, we propose a method of integrating the univariate results of a meta-analysis with a clinical dataset and expert knowledge to construct multivariate Bayesian network (BN) models. The technique reduces the size of the dataset needed to learn the parameters of a model of a given complexity. Supplementing the data with the meta-analysis results avoids the need to either simplify the model - ignoring some complexities of the problem - or to gather more data. The method is illustrated by a clinical case study into the prediction of the viability of severely injured lower extremities. The case study illustrates the advantages of integrating combined evidence into BN development: the BN developed using our method outperformed four different data-driven structure learning methods, and a well-known scoring model (MESS) in this domain. (C) 2014 Elsevier Inc. All rights reserved. C1 [Yet, Barbaros; Marsh, D. William R.] Queen Mary Univ London, Sch Elect Engn & Comp Sci, London E1 4NS, England. [Perkins, Zane B.] Queen Mary Univ London, Ctr Trauma Sci, London E1 4NS, England. [Rasmussen, Todd E.] US Army Med Res & Mat Command, Ft Detrick, MD USA. [Tai, Nigel R. M.] Royal London Hosp, London E1 1BB, England. RP Yet, B (reprint author), Queen Mary Univ London, Sch Elect Engn & Comp Sci, Risk & Informat Management Res Grp, Room CS332,West Sq, London E1 4NS, England. EM b.yet@qmul.ac.uk RI Marsh, David/A-3213-2016; OI Marsh, David/0000-0003-0212-6363; Yet, Barbaros/0000-0003-4058-2677 NR 41 TC 3 Z9 3 U1 0 U2 11 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1532-0464 EI 1532-0480 J9 J BIOMED INFORM JI J. Biomed. Inform. PD DEC PY 2014 VL 52 BP 373 EP 385 DI 10.1016/jpi.2014.07.018 PG 13 WC Computer Science, Interdisciplinary Applications; Medical Informatics SC Computer Science; Medical Informatics GA AY0HC UT WOS:000347277000038 PM 25111037 ER PT J AU Liu, LB Arcone, SA AF Liu, Lanbo Arcone, Steven A. TI Introduction to the GPR for Hydrogeology and Groundwater Problems Special Issue of JEEG SO JOURNAL OF ENVIRONMENTAL AND ENGINEERING GEOPHYSICS LA English DT Editorial Material C1 [Liu, Lanbo] Univ Connecticut, Sch Engn, Storrs, CT 06269 USA. [Arcone, Steven A.] ERDC Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Liu, LB (reprint author), Univ Connecticut, Sch Engn, 261 Glenbrook Rd, Storrs, CT 06269 USA. NR 1 TC 0 Z9 0 U1 0 U2 5 PU ENVIRONMENTAL ENGINEERING GEOPHYSICAL SOC PI DENVER PA 1720 SOUTH BELLAIRE, STE 110, DENVER, CO 80222-433 USA SN 1083-1363 J9 J ENVIRON ENG GEOPH JI J. Environ. Eng. Geophys. PD DEC PY 2014 VL 19 IS 4 SI SI BP 205 EP 206 DI 10.2113/JEEG19.4.205 PG 2 WC Geochemistry & Geophysics; Engineering, Geological SC Geochemistry & Geophysics; Engineering GA AX5DG UT WOS:000346946600001 ER PT J AU Arcone, S Campbell, S Pfeffer, WT AF Arcone, Steven Campbell, Seth Pfeffer, W. Tad TI GPR Profiles of Glacial Till and its Transition to Bedrock: Interpretation of Water Content, Depth and Signal Loss from Diffractions SO JOURNAL OF ENVIRONMENTAL AND ENGINEERING GEOPHYSICS LA English DT Article ID GROUND-PENETRATING RADAR; WISCONSINAN MOUNTAIN-GLACIATION; NORTHERN PRESIDENTIAL RANGE; NEW-HAMPSHIRE; SHEET STRUCTURE; NEW-ENGLAND; SCATTERING; ORIGIN; ATTENUATION; PROPAGATION AB We discuss GPR reflection profiles that we recorded on glacial till and a colluvial diamict at several locations in New Hampshire, and from which we interpret water contents, depths and rates of signal loss. We used pulses centered from 150-200 MHz and 300-360 MHz. The boulder-rich sediments reside over granitic and metavolcanics, the horizons of which we recognize from the relative strengths and phase of their waveforms, underlying fractures, and well-developed diffraction asymptotes. The till produced an apparent dense distribution of diffractions with limited asymptotes and dispersion, and occasional minor stratification. We use these diffractions and moveout profiles to calculate relative dielectric permittivities between 17 and 27, values which suggest up to 30% volumetric water, and likely saturation within these over-consolidated sediments. The evidence for transitions from till to bedrock ranges from a simple horizon to complex horizon segments, all characterized by diffractions and amenable to single-layer migration. A gradational loss in diffraction strength with depth suggests gradational weathering or changes in grain size as the cause. Maximum profiled depths range from 4 m to at least 10 m, with estimated scattering attenuation rates of about 3.3 dB m(-1). In contrast, one and possible two colluvial diamicts, which likely contained 3-m-size boulders, show short segments of stratification, rare diffraction asymptotes, allow more than 20-m penetration and provide scattering losses of about 0.5 dB m(-1). We measured extremely low conductivity and calculated permittivities ranging from 9-12, which suggest high densities and volumetric water content of 4-12%. Low, single scattering loss and deep penetration in the till are consistent with evidence of ground waves traveling up to 40 m one way. The phase polarity of waveforms within till and colluvial events show they may originate from either high or low dielectric contrasts, likely related to water or large boulders, respectively. C1 [Arcone, Steven] US Army, Cold Reg Res & Engn Lab, ERDC, Hanover, NH 03755 USA. [Campbell, Seth] Univ Maine, Climate Change Inst, Orono, ME 04469 USA. [Pfeffer, W. Tad] Inst Arct & Alpine Res, Boulder, CO 80309 USA. [Pfeffer, W. Tad] Univ Colorado, Dept Civil Environm & Architectural Engn, Boulder, CO 80309 USA. RP Arcone, S (reprint author), US Army, Cold Reg Res & Engn Lab, ERDC, 72 Lyme Rd, Hanover, NH 03755 USA. EM Steven.A.Arcone@usace.army.mil; Seth_Campbell@umit.maine.edu; Tad.pfeffer@Colorado.edu FU U.S. Army Engineer Research and Development Center 6.1 program in basic research FX This work was supported by the U.S. Army Engineer Research and Development Center 6.1 program in basic research. Permission to publish was granted by the Director, Cold Regions Research and Engineering Laboratory. NR 51 TC 1 Z9 1 U1 4 U2 12 PU ENVIRONMENTAL ENGINEERING GEOPHYSICAL SOC PI DENVER PA 1720 SOUTH BELLAIRE, STE 110, DENVER, CO 80222-433 USA SN 1083-1363 J9 J ENVIRON ENG GEOPH JI J. Environ. Eng. Geophys. PD DEC PY 2014 VL 19 IS 4 SI SI BP 207 EP 228 DI 10.2113/JEEG19.4.207 PG 22 WC Geochemistry & Geophysics; Engineering, Geological SC Geochemistry & Geophysics; Engineering GA AX5DG UT WOS:000346946600002 ER PT J AU Turell, MJ Dohm, DJ Fonseca, DM AF Turell, Michael J. Dohm, David J. Fonseca, Dina M. TI COMPARISON OF THE POTENTIAL FOR DIFFERENT GENETIC FORMS IN THE CULEX PIPIENS COMPLEX IN NORTH AMERICA TO TRANSMIT RIFT VALLEY FEVER VIRUS SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Transmission; form pipiens; form molestus; hybrids; vector competence; arbovirus ID WEST-NILE-VIRUS; MOSQUITOS DIPTERA-CULICIDAE; VECTOR COMPETENCE; SAUDI-ARABIA; NEW-YORK; POPULATION-STRUCTURE; MOLESTUS; EPIDEMIC; HYBRIDIZATION; AFRICA AB Rift Valley fever virus (RVFV), a mosquito-borne virus, has been responsible for large outbreaks in Africa that have resulted in hundreds of thousands of human infections and major economic disruption due to loss of livestock and to trade restrictions. Culex pipiens was implicated as the principal vector of the Egyptian outbreak in 1977 that affected about 200,000 people. In the northern USA, Cx. pipiens occurs both as a mix of forms pipiens and molestus (i.e., US Culex pipiens) as well as pure Cx. pipiens form molestus, the latter mostly in underground locations such as sewers and basements. In order to understand the potential risk of spread of RVFV in the USA, we compared their relative abilities to transmit RVFV in the laboratory. After feeding on hamsters with high viremias, >10(9) plaque-forming units (PFU)/ml, both US Cx. pipiens and Cx. pipiens form molestus were highly susceptible to infection (similar to 80%) and about 20% of each form developed a disseminated infection. In contrast, when fed on a hamster with a moderate viremia, 10(7.5) PFU/ml, US Cx. pipiens were significantly (P < 0.001) more susceptible (84%) than were the pure form molestus (47%). Similarly, dissemination rates were significantly (P = 0.0261) higher in US Cx. pipiens (34%) than they were in pure Cx. pipiens form molestus (10%). These results underscore differences in vector competence between genetic forms in the Cx. pipiens complex but also indicate that if RVFV were to arrive in the USA, competent vectors abound in the highly urbanized Northeast. C1 [Turell, Michael J.; Dohm, David J.] US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Fonseca, Dina M.] Rutgers State Univ, Ctr Vector Biol, New Brunswick, NJ 08901 USA. [Fonseca, Dina M.] Rutgers State Univ, Dept Entomol, New Brunswick, NJ 08901 USA. RP Turell, MJ (reprint author), US Army, Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA. OI Fonseca, Dina/0000-0003-4726-7100 FU USDA-ARS [5410-32000-015-00D, 5410-32000-018-00D]; Department of Homeland Security Interagency Agreement [HSHQDC-07-X-00982] FX We thank Linda McCuiston (Rutgers University) for establishing and maintaining most mosquito colonies at the Center for Vector Biology for >40 years and dedicate this manuscript to her-Mrs. McCuiston retired in 2014 and medical entomology is losing an invaluable resource-Denise Nash (USAMRIID) for caring for mosquitoes, and J. Williams (USAMRIID) for caring for the hamsters. This project was funded in part by USDA-ARS CRIS projects 5410-32000-015-00D, 5410-32000-018-00D, and a Department of Homeland Security Interagency Agreement HSHQDC-07-X-00982. NR 63 TC 4 Z9 4 U1 0 U2 8 PU AMER MOSQUITO CONTROL ASSOC PI MOUNT LAUREL PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA SN 8756-971X EI 1943-6270 J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD DEC PY 2014 VL 30 IS 4 BP 253 EP 259 DI 10.2987/14-6441R.1 PG 7 WC Entomology SC Entomology GA AX7GQ UT WOS:000347085200001 PM 25843130 ER PT J AU Kim, Y Blank, S AF Kim, Younkyoo Blank, Stephen TI Putin and Korea's "Silk Road Express": Russia's Game on the Korean Peninsula SO KOREA OBSERVER LA English DT Article DE Russia; North Korea; Silk Road Express; Eurasia Initiative AB Moscow has shown interest in reducing tensions on the Korean peninsula through promotion of three major trilateral (RF-DPRK-ROK) infrastructure projects: uniting the railroads in both Koreas with the Tran-Siberian Railway as well as constructing gas pipelines and power lines from Primorye to South Korea through North Korea. North Korea's "rapprochement" with Russia is both the result of moves occurring among actors in this game and, at the same time itself a stimulus to ongoing and concurrent reactions by those players. After it reviews the trilateral cooperation among Russia-North Korea-South Korea regarding the gas pipeline in 2011-2012, this article examines the trilateral cooperation regarding railways in 2013-2014. C1 [Kim, Younkyoo] Hanyang Univ, Div Int Studies, Seoul, South Korea. [Kim, Younkyoo] Hanyang Univ, Ctr Energy Governance & Secur EGS, Seoul, South Korea. [Blank, Stephen] Amer Foreign Policy Council, Washington, DC USA. [Blank, Stephen] US Army War Coll, Natl Secur Affairs Strateg Studies Inst, Carlisle, PA USA. RP Kim, Y (reprint author), Hanyang Univ, Div Int Studies, Seoul, South Korea. EM younkyookim@hotmail.com; blank@afpc.org NR 31 TC 0 Z9 0 U1 1 U2 7 PU INST KOREAN STUDIES PI SEOUL PA CPO BOX 3410, SEOUL, 100-364, SOUTH KOREA SN 0023-3919 J9 KOREA OBS JI Korea Obs. PD WIN PY 2014 VL 45 IS 4 BP 599 EP 626 PG 28 WC Area Studies; International Relations SC Area Studies; International Relations GA AX2DX UT WOS:000346754900005 ER PT J AU Ferguson, JB Schultz, BF Cho, K Rohatgi, PK AF Ferguson, J. B. Schultz, Benjamin F. Cho, Kyu Rohatgi, Pradeep K. TI Correlation vs. Causation: The Effects of Ultrasonic Melt Treatment on Cast Metal Grain Size SO METALS LA English DT Article DE ultrasonic cavitation; grain refinement; metals and alloys; nucleation ID AZ91 MAGNESIUM ALLOY; MICROSTRUCTURE; SOLIDIFICATION; TEMPERATURE AB Interest in ultrasonic treatment of liquid metal has waxed and waned for nearly 80 years. A review of several experiments representative of ultrasonic cavitation treatment of Al and Mg alloys shows that the theoretical mechanisms thought to be responsible for grain refinement are (1) cavitation-induced increase in melting temperature predicted by the Clausius-Clapeyron equation and (2) cavitation-induced wetting of otherwise unwetted insoluble particles. Neither of these theoretical mechanisms can be directly confirmed by experiment, and though they remain speculative, the available literature generally assumes that one or the other or both mechanisms are active. However, grain size is known to depend on temperature of the liquid, temperature of the mold, and cooling rate of the entire system. From the reviewed experiments, it is difficult to isolate temperature and cooling rate effects on grain size from the theoretical effects. Ultrasonic treatments of Al-A356 were carried out to isolate such effects, and though it was found that ultrasound produced significant grain refinement, the treatments also significantly chilled the liquid and thereby reduced the pouring temperature. The grain sizes attained closely correlated with pouring temperature suggesting that ultrasonic grain refinement is predominantly a result of heat removal by the horn and ultrasonic stirring. C1 [Ferguson, J. B.; Schultz, Benjamin F.; Rohatgi, Pradeep K.] Univ Wisconsin, Mat Sci & Engn Dept, Milwaukee, WI 53211 USA. [Cho, Kyu] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Schultz, BF (reprint author), Univ Wisconsin, Mat Sci & Engn Dept, 3200 N Cramer St, Milwaukee, WI 53211 USA. EM jbf2@uwm.edu; bfs2@uwm.edu; kyu.c.cho2.civ@mail.mil; prohatgi@uwm.edu FU U.S. Army Research Laboratory [W911NF-08-2-0014] FX The authors would like to thank Scott Derse for his assistance in performing the ultrasonic cavitation experiments. This material is based upon work supported by the U.S. Army Research Laboratory under Cooperative Agreement No. W911NF-08-2-0014. The views, opinions, and conclusions made in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 20 TC 2 Z9 2 U1 2 U2 21 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2075-4701 J9 METALS-BASEL JI Metals PD DEC PY 2014 VL 4 IS 4 BP 477 EP 489 DI 10.3390/met4040477 PG 13 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA AX4MI UT WOS:000346906200002 ER PT J AU Cox, J Luong, DD Shunmugasamy, VC Gupta, N Strbik, OM Cho, K AF Cox, James Luong, Dung D. Shunmugasamy, Vasanth Chakravarthy Gupta, Nikhil Strbik, Oliver M., III Cho, Kyu TI Dynamic and Thermal Properties of Aluminum Alloy A356/Silicon Carbide Hollow Particle Syntactic Foams SO METALS LA English DT Article DE metal matrix syntactic foam; SiC hollow particle; high strain rate compression; damping parameter ID METAL-MATRIX COMPOSITES; PRESSURE INFILTRATION TECHNIQUE; HIGH-STRAIN RATES; COMPRESSIVE PROPERTIES; POWDER-METALLURGY; MECHANICAL-PROPERTIES; DAMPING BEHAVIOR; DENSITY; MICROSTRUCTURE; MICROSPHERES AB Aluminum alloy A356 matrix syntactic foams filled with SiC hollow particles (SiCHP) are studied in the present work. Two compositions of syntactic foams are studied for quasi-static and high strain rate compression. In addition, dynamic mechanical analysis is conducted to study the temperature dependent energy dissipation and damping capabilities of these materials. The thermal characterization includes study of the coefficient of thermal expansion (CTE). A356/SiCHP syntactic foams are not strain rate sensitive as the compressive strength displayed little variation between the tested strain rates of 0.001-2100 s(-1). Microscopic analysis of the high strain rate compression tested specimens showed that the fracture is initiated by the failure of hollow particles at the onset of the plastic deformation region. This is followed by plastic deformation of the matrix material and further crushing of particles. The syntactic foams showed decrease in storage modulus with increasing temperature and the trend was nearly linear up to 500 degrees C. The alloy shows a similar behavior at low temperature but the decrease in storage modulus increases sharply over 375 degrees C. The loss modulus is very small for the tested materials because of lack of viscoelasticity in metallic materials. The trend in the loss modulus is opposite, where the matrix alloy has lower loss modulus than syntactic foams at low temperature. However, over 250 degrees C the matrix loss modulus starts to increase rapidly and attains a peak around 460 degrees C. Syntactic foams have higher damping parameter at low temperatures than the matrix alloy. Incorporation of SiCHP helps in decreasing CTE. Compared to the CTE of the matrix alloy, 23.4 x 10(-6) degrees C-1, syntactic foams showed CTE values as low as 11.67 x 10(-6) degrees C-1. C1 [Cox, James; Luong, Dung D.; Shunmugasamy, Vasanth Chakravarthy; Gupta, Nikhil] NYU, Polytech Sch Engn, Mech & Aerosp Engn Dept, Composite Mat & Mech Lab, Brooklyn, NY 11201 USA. [Strbik, Oliver M., III] Deep Springs Technol LLC, Toledo, OH 43615 USA. [Cho, Kyu] US Army, RDRL, WMMD, Aberdeen Proving Ground, MD 21005 USA. RP Gupta, N (reprint author), NYU, Polytech Sch Engn, Mech & Aerosp Engn Dept, Composite Mat & Mech Lab, Brooklyn, NY 11201 USA. EM jc5430@nyu.edu; ddl268@nyu.edu; vs860@nyu.edu; ngupta@nyu.edu; ostrbik@teamdst.com; kyu.c.cho2.civ@mail.mil RI Shunmugasamy, Vasanth Chakravarthy/P-8618-2016 OI Shunmugasamy, Vasanth Chakravarthy/0000-0003-4818-004X FU U.S. Army Research Laboratory of DST [W911NF-10-2-0084]; NYU [W911NF-11-2-0096]; National Science Foundation [DGE-0741714]; Central Brooklyn STEM Initiative (CBSI); J.P. Morgan Chase Foundation; Motorola Innovation Generation Grant; NY Space Grant Consortium; Xerox Foundation; White Cedar Fund; Black Male Donor Collaborative, Brooklyn Community Foundation FX This research is sponsored by the U.S. Army Research Laboratory contract W911NF-10-2-0084 of DST and the Cooperative Agreement W911NF-11-2-0096 with NYU. James was supported in part by the National Science Foundation under a GK-12 Fellows grant DGE-0741714: Applying Mechatronics to Promote Science. The program was also supported in part by the Central Brooklyn STEM Initiative (CBSI), which is funded by the Black Male Donor Collaborative, Brooklyn Community Foundation, J.P. Morgan Chase Foundation, Motorola Innovation Generation Grant, NY Space Grant Consortium, Xerox Foundation, and White Cedar Fund. Steven E. Zeltmann is thanked for help in manuscript preparation. NR 47 TC 9 Z9 9 U1 6 U2 38 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2075-4701 J9 METALS-BASEL JI Metals PD DEC PY 2014 VL 4 IS 4 BP 530 EP 548 DI 10.3390/met4040530 PG 19 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA AX4MI UT WOS:000346906200006 ER PT J AU Brennan, CVW Walck, SD Swab, JJ AF Brennan, Claire V. Weiss Walck, Scott D. Swab, Jeffrey J. TI A Multi-Step Transmission Electron Microscopy Sample Preparation Technique for Cracked, Heavily Damaged, Brittle Materials SO MICROSCOPY AND MICROANALYSIS LA English DT Article DE transmission electron microscopy; sample preparation; cracked materials; brittle materials; ceramics AB A new technique for the preparation of heavily cracked, heavily damaged, brittle materials for examination in a transmission electron microscope (TEM) is described in detail. In this study, cross-sectional TEM samples were prepared from indented silicon carbide (SiC) bulk ceramics, although this technique could also be applied to other brittle and/or multiphase materials. During TEM sample preparation, milling-induced damage must be minimized, since in studying deformation mechanisms, it would be difficult to distinguish deformation-induced cracking from cracking occurring due to the sample preparation. The samples were prepared using a site-specific, two-step ion milling sequence accompanied by epoxy vacuum infiltration into the cracks. This technique allows the heavily cracked, brittle ceramic material to stay intact during sample preparation and also helps preserve the true microstructure of the cracked area underneath the indent. Some preliminary TEM results are given and discussed in regards to deformation studies in ceramic materials. This sample preparation technique could be applied to other cracked and/or heavily damaged materials, including geological materials, archaeological materials, fatigued materials, and corrosion samples. C1 [Brennan, Claire V. Weiss; Swab, Jeffrey J.] US Army, Res Lab, Weap & Mat Res Directorate, Ceram & Transparent Mat Branch,RDRL WMM E, Aberdeen Proving Ground, MD 21005 USA. [Walck, Scott D.] US Army, Res Lab, Weap & Mat Res Directorate,RDRL WMM C, Coatings Corros & Engn Polymers Branch,TKC Global, Aberdeen Proving Ground, MD 21005 USA. RP Brennan, CVW (reprint author), US Army, Res Lab, Weap & Mat Res Directorate, Ceram & Transparent Mat Branch,RDRL WMM E, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. EM claire.v.brennan.civ@mail.mil FU United States Army Research Laboratory; TKC Global FX The authors would like to thank Wendy Sarney, Kelvin Xie, Jason Robinnette, and Jerry LaSalvia for their help. The authors acknowledge the United States Army Research Laboratory and TKC Global for their support. NR 7 TC 0 Z9 0 U1 1 U2 3 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1431-9276 EI 1435-8115 J9 MICROSC MICROANAL JI Microsc. microanal. PD DEC PY 2014 VL 20 IS 6 BP 1646 EP 1653 DI 10.1017/S1431927614013257 PG 8 WC Materials Science, Multidisciplinary; Microscopy SC Materials Science; Microscopy GA AX9PD UT WOS:000347233400003 ER PT J AU Saxer, G Krepps, MD Merkley, ED Ansong, C Kaiser, BLD Valovska, MT Ristic, N Yeh, PT Prakash, VP Leiser, OP Nakhleh, L Gibbons, HS Kreuzer, HW Shamoo, Y AF Saxer, Gerda Krepps, Michael D. Merkley, Eric D. Ansong, Charles Kaiser, Brooke L. Deatherage Valovska, Marie-Therese Ristic, Nikola Yeh, Ping T. Prakash, Vittal P. Leiser, Owen P. Nakhleh, Luay Gibbons, Henry S. Kreuzer, Helen W. Shamoo, Yousif TI Mutations in Global Regulators Lead to Metabolic Selection during Adaptation to Complex Environments SO PLOS GENETICS LA English DT Article ID ESCHERICHIA-COLI POPULATIONS; TERM EXPERIMENTAL EVOLUTION; ADAPTIVE RADIATION; TRANSCRIPTIONAL MICROARRAYS; ECOLOGICAL SPECIALIZATION; MONITORING UTILIZATION; ANTIBIOTIC-RESISTANCE; BENEFICIAL MUTATIONS; CONSTANT ENVIRONMENT; SIGNAL-TRANSDUCTION AB Adaptation to ecologically complex environments can provide insights into the evolutionary dynamics and functional constraints encountered by organisms during natural selection. Adaptation to a new environment with abundant and varied resources can be difficult to achieve by small incremental changes if many mutations are required to achieve even modest gains in fitness. Since changing complex environments are quite common in nature, we investigated how such an epistatic bottleneck can be avoided to allow rapid adaptation. We show that adaptive mutations arise repeatedly in independently evolved populations in the context of greatly increased genetic and phenotypic diversity. We go on to show that weak selection requiring substantial metabolic reprogramming can be readily achieved by mutations in the global response regulator arcA and the stress response regulator rpoS. We identified 46 unique single-nucleotide variants of arcA and 18 mutations in rpoS, nine of which resulted in stop codons or large deletions, suggesting that subtle modulations of ArcA function and knockouts of rpoS are largely responsible for the metabolic shifts leading to adaptation. These mutations allow a higher order metabolic selection that eliminates epistatic bottlenecks, which could occur when many changes would be required. Proteomic and carbohydrate analysis of adapting E. coli populations revealed an up-regulation of enzymes associated with the TCA cycle and amino acid metabolism, and an increase in the secretion of putrescine. The overall effect of adaptation across populations is to redirect and efficiently utilize uptake and catabolism of abundant amino acids. Concomitantly, there is a pronounced spread of more ecologically limited strains that results from specialization through metabolic erosion. Remarkably, the global regulators arcA and rpoS can provide a "one-step'' mechanism of adaptation to a novel environment, which highlights the importance of global resource management as a powerful strategy to adaptation. C1 [Saxer, Gerda; Valovska, Marie-Therese; Yeh, Ping T.; Prakash, Vittal P.; Shamoo, Yousif] Rice Univ, Dept Biosci, Houston, TX 77251 USA. [Krepps, Michael D.; Gibbons, Henry S.] US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. [Krepps, Michael D.] EXCET Inc, Springfield, VA USA. [Merkley, Eric D.; Ansong, Charles; Kaiser, Brooke L. Deatherage; Kreuzer, Helen W.] Pacific NW Natl Lab, Richland, WA 99352 USA. [Ristic, Nikola; Nakhleh, Luay] Rice Univ, Dept Comp Sci, Houston, TX USA. [Leiser, Owen P.] No Arizona Univ, Ctr Microbial Genet & Genom, Flagstaff, AZ 86011 USA. RP Saxer, G (reprint author), Rice Univ, Dept Biosci, Houston, TX 77251 USA. EM gsaxer@rice.edu; shamoo@rice.edu OI Merkley, Eric/0000-0002-5486-4723 FU Defense Threat Reduction Agency [HDTRA-1-10-1-0069, DTRA10027IA-2129]; U.S. Department of Energy [DE-AC06-76RLO] FX This work was supported by funding from the Defense Threat Reduction Agency (HDTRA-1-10-1-0069) to YS and (DTRA10027IA-2129) to HWK. Pacific Northwest National Laboratory is operated by Battelle Memorial Institute for the U.S. Department of Energy under contract DE-AC06-76RLO. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 86 TC 11 Z9 11 U1 3 U2 30 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-7390 EI 1553-7404 J9 PLOS GENET JI PLoS Genet. PD DEC PY 2014 VL 10 IS 12 AR e1004872 DI 10.1371/journal.pgen.1004872 PG 17 WC Genetics & Heredity SC Genetics & Heredity GA AX0NW UT WOS:000346649900065 PM 25501822 ER PT J AU Schuetz, A Deleage, C Sereti, I Rerknimitr, R Phanuphak, N Phuang-Ngern, Y Estes, JD Sandler, NG Sukhumvittaya, S Marovich, M Jongrakthaitae, S Akapirat, S Fletscher, JLK Kroon, E Dewar, R Trichavaroj, R Chomchey, N Douek, DC O'Connell, RJ Ngauy, V Robb, ML Phanuphak, P Michael, NL Excler, JL Kim, JH de Souza, MS Ananworanich, J AF Schuetz, Alexandra Deleage, Claire Sereti, Irini Rerknimitr, Rungsun Phanuphak, Nittaya Phuang-Ngern, Yuwadee Estes, Jacob D. Sandler, Netanya G. Sukhumvittaya, Suchada Marovich, Mary Jongrakthaitae, Surat Akapirat, Siriwat Fletscher, James L. K. Kroon, Eugene Dewar, Robin Trichavaroj, Rapee Chomchey, Nitiya Douek, Daniel C. O'Connell, Robert J. Ngauy, Viseth Robb, Merlin L. Phanuphak, Praphan Michael, Nelson L. Excler, Jean-Louis Kim, Jerome H. de Souza, Mark S. Ananworanich, Jintanat CA RV254 SEARCH 010 Study Grp RV304 SEARCH 013 Study Grp TI Initiation of ART during Early Acute HIV Infection Preserves Mucosal Th17 Function and Reverses HIV-Related Immune Activation SO PLOS PATHOGENS LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; REGULATORY T-CELLS; ANTIRETROVIRAL THERAPY; MICROBIAL TRANSLOCATION; TYPE-1 INFECTION; LYMPHOID-TISSUE; PERIPHERAL LYMPHOCYTES; LENTIVIRAL INFECTIONS; DISEASE PROGRESSION; GENE-EXPRESSION AB Mucosal Th17 cells play an important role in maintaining gut epithelium integrity and thus prevent microbial translocation. Chronic HIV infection is characterized by mucosal Th17 cell depletion, microbial translocation and subsequent immune-activation, which remain elevated despite antiretroviral therapy (ART) correlating with increased mortality. However, when Th17 depletion occurs following HIV infection is unknown. We analyzed mucosal Th17 cells in 42 acute HIV infection (AHI) subjects (Fiebig (F) stage I-V) with a median duration of infection of 16 days and the short-term impact of early initiation of ART. Th17 cells were defined as IL-17+ CD4+ T cells and their function was assessed by the co-expression of IL-22, IL-2 and IFN gamma. While intact during FI/II, depletion of mucosal Th17 cell numbers and function was observed during FIII correlating with local and systemic markers of immune-activation. ART initiated at FI/II prevented loss of Th17 cell numbers and function, while initiation at FIII restored Th17 cell numbers but not their polyfunctionality. Furthermore, early initiation of ART in FI/II fully reversed the initially observed mucosal and systemic immune-activation. In contrast, patients treated later during AHI maintained elevated mucosal and systemic CD8+ T-cell activation post initiation of ART. These data support a loss of Th17 cells at early stages of acute HIV infection, and highlight that studies of ART initiation during early AHI should be further explored to assess the underlying mechanism of mucosal Th17 function preservation. C1 [Schuetz, Alexandra; Phuang-Ngern, Yuwadee; Sukhumvittaya, Suchada; Jongrakthaitae, Surat; Akapirat, Siriwat; Kroon, Eugene; Trichavaroj, Rapee; O'Connell, Robert J.; Ngauy, Viseth; de Souza, Mark S.] Armed Forces Res Inst Med Sci US Component, Dept Retrovirol, Bangkok, Thailand. [Schuetz, Alexandra; Robb, Merlin L.; Excler, Jean-Louis; Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Deleage, Claire; Estes, Jacob D.] Frederick Natl Lab Canc Res, Leidos Biomed Res Inc, AIDS & Canc Virus Program, Frederick, MD USA. [Sereti, Irini] NIAID, Clin & Mol Retrovirol Sect, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA. [Rerknimitr, Rungsun; Phanuphak, Praphan] Chulalongkorn Univ, Fac Med, Dept Med, Bangkok 10330, Thailand. [Phanuphak, Nittaya; Fletscher, James L. K.; Kroon, Eugene; Chomchey, Nitiya; Phanuphak, Praphan; Kim, Jerome H.; de Souza, Mark S.; Ananworanich, Jintanat] SEARCH, Bangkok, Thailand. [Phanuphak, Nittaya; Chomchey, Nitiya; Phanuphak, Praphan; Ananworanich, Jintanat] Thai Red Cross AIDS Res Ctr, Bangkok, Thailand. [Sandler, Netanya G.; Douek, Daniel C.] NIAID, Human Immunol Sect, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. [Marovich, Mary; Robb, Merlin L.; Michael, Nelson L.; Excler, Jean-Louis; Kim, Jerome H.; Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Dewar, Robin] NCI, Virus Isolat & Serol Lab Appl & Dev Res Directora, Frederick Inc, Frederick Canc Res & Dev Ctr, Frederick, MD 21701 USA. RP Schuetz, A (reprint author), Armed Forces Res Inst Med Sci US Component, Dept Retrovirol, Bangkok, Thailand. EM schuetza@afrims.org OI Utay, Netanya/0000-0002-6407-8670 FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DOD) [W81XWH-07-2-0067]; Thai Red Cross AIDS Research Center; UCLA CFAR grant [5P30 AI028697]; NIAID/NIH FX This work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD) and by an intramural grant from the Thai Red Cross AIDS Research Center. Antiretroviral therapy was supported by the Thai Government Pharmaceutical Organization, Gilead, Merck and ViiV Healthcare. The UCLA CFAR Mucosal Immunology Core Laboratory is funded by UCLA CFAR grant 5P30 AI028697 and provided support and guidance regarding the isolation of MMC. The work of Irini Sereti was supported by Intramural Research Program of NIAID/NIH. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 79 TC 63 Z9 63 U1 0 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-7366 EI 1553-7374 J9 PLOS PATHOG JI PLoS Pathog. PD DEC PY 2014 VL 10 IS 12 AR e1004543 DI 10.1371/journal.ppat.1004543 PG 15 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA AX1JB UT WOS:000346702400030 PM 25503054 ER PT J AU Berkowitz, JF Page, S Noble, CV AF Berkowitz, Jacob F. Page, Sanderson Noble, Chris V. TI Potential Disconnect Between Observations of Hydrophytic Vegetation, Wetland Hydrology Indicators, and Hydric Soils in Unique Pitcher Plant Bog Habitats of the Southern Gulf Coast SO SOUTHEASTERN NATURALIST LA English DT Article ID IRIS AB The Sarracenia spp. (pitcher plant) bogs located along the southern Gulf of Mexico represent a unique natural resource characterized by endangered and endemic wetland floral communities that include a number of carnivorous plants (e.g., pitcher plants and Drosera spp. [sundews]). Despite the prevalence of obligate wetland plant species and indicators of wetland hydrology, the soils underlying this niche ecosystem often lack clear indicators of hydric soil morphology, posing challenges to wetland delineation and resource management. The National Technical Committee for Hydric Soils and an interagency team of soil scientists investigated saturated conditions and anaerobic soil conditions in pitcher plant bogs. Our results demonstrate that many of the pitcher plant-bog soils examined failed to meet an approved hydric soil indicator. Herein, we discuss potential factors preventing the formation of typical hydric soil morphologies including: low organic-matter content, high iron-concentrations, extensive bioturbation, presence of high-chroma minerals (e.g., chert), and short saturation-intervals. Our examination of soil morphology and condition in these unique and ecologically valuable habitats indicates that additional studies are required to address the apparent disconnect between observations of soils, hydrophytic vegetation, and indicators of wetland hydrology to ensure the appropriate management of these endemic natural resources. C1 [Berkowitz, Jacob F.; Noble, Chris V.] US Army Corps Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Page, Sanderson] Nat Resources Conservat Serv, USDA, Loxey, AL 36551 USA. RP Berkowitz, JF (reprint author), US Army Corps Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM Jacob.F.Berkowitz@usace.army.mil NR 38 TC 0 Z9 0 U1 3 U2 29 PU HUMBOLDT FIELD RESEARCH INST PI STEUBEN PA PO BOX 9, STEUBEN, ME 04680-0009 USA SN 1528-7092 EI 1938-5412 J9 SOUTHEAST NAT JI Southeast. Nat. PD DEC PY 2014 VL 13 IS 4 BP 721 EP 734 DI 10.1656/058.013.0410 PG 14 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA AX8QF UT WOS:000347173000015 ER PT J AU Manning, JE Satharath, P Gaywee, J Lopez, MN Lon, C Saunders, DL AF Manning, Jessica E. Satharath, Prom Gaywee, Jariyanart Nila Lopez, Maria Lon, Chanthap Saunders, David L. TI Fighting the good fight: the role of militaries in malaria elimination in Southeast Asia SO TRENDS IN PARASITOLOGY LA English DT Review DE malaria elimination; military; Southeast Asia ID GREATER MEKONG SUBREGION; UNCOMPLICATED PLASMODIUM-FALCIPARUM; ISOTHERMAL AMPLIFICATION ASSAY; ARTEMISININ-RESISTANT MALARIA; INDIVIDUAL PATIENT DATA; SUB-SAHARAN AFRICA; DIHYDROARTEMISININ-PIPERAQUINE; ARTESUNATE-AMODIAQUINE; GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCY; ARTEMETHER-LUMEFANTRINE AB Despite significant progress in malaria control in the Greater Mekong Subregion (GMS), malaria is still endemic, with more than 30 million people infected annually. Important gaps remain in case management, service delivery, prevention, and vector control, particularly in hard-to-reach mobile populations. Rapidly evolving drug resistance has created a new urgency to move aggressively toward elimination. However, no clear and cost-effective strategy has been identified. Although GMS militaries are under-recognized as a malaria transmission reservoir, they are an important focal point for elimination activities, given their high mobility, frequent malaria exposure, and potential for asymptomatic carriage. At the same time, military organizational capacity and proximity to other mobile populations could facilitate elimination efforts if relevant political barriers could be overcome. Here, we review considerations for military involvement in regional malaria elimination efforts. C1 [Manning, Jessica E.; Lon, Chanthap; Saunders, David L.] Armed Forces Res Inst Med Sci, US Army Med Component, Dept Immunol & Med, Bangkok 10400, Thailand. [Satharath, Prom] Royal Cambodian Armed Forces, Phnom Penh, Cambodia. [Gaywee, Jariyanart] Royal Thai Army, Bangkok, Thailand. [Nila Lopez, Maria] Armed Forces Philippines, Manila, Philippines. [Lon, Chanthap] Armed Forces Res Inst Med Sci, US Army Med Component, Phnom Penh, Cambodia. RP Saunders, DL (reprint author), Armed Forces Res Inst Med Sci, US Army Med Component, Dept Immunol & Med, Bangkok 10400, Thailand. EM david.saunders@afrims.org NR 90 TC 4 Z9 5 U1 0 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1471-4922 EI 1471-5007 J9 TRENDS PARASITOL JI Trends Parasitol. PD DEC PY 2014 VL 30 IS 12 BP 571 EP 581 DI 10.1016/j.pt.2014.10.002 PG 11 WC Parasitology SC Parasitology GA AX8DK UT WOS:000347140400006 PM 25455566 ER PT J AU Kott, A Swami, A McDaniel, P AF Kott, Alexander Swami, Ananthram McDaniel, Patrick TI Security Outlook: Six Cyber Game Changers for the Next 15 Years SO COMPUTER LA English DT Editorial Material AB Six potential cyber game changers gleaned from a recent long-range planning symposium can help experts identify priorities for future cybersecurity research and development. C1 [Kott, Alexander; Swami, Ananthram] US Army Res Lab, Network Sci Div, Adelphi, MD 20783 USA. [McDaniel, Patrick] Penn State Univ, Dept Comp Sci & Engn, University Pk, PA 16802 USA. RP Kott, A (reprint author), US Army Res Lab, Network Sci Div, Adelphi, MD 20783 USA. EM alexander.kott1.civ@mail.mil; ananthram.swami.civ@mail.mil; mcdaniel@cse.psu.edu NR 5 TC 1 Z9 1 U1 1 U2 5 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 0018-9162 EI 1558-0814 J9 COMPUTER JI Computer PD DEC PY 2014 VL 47 IS 12 BP 104 EP 106 PG 3 WC Computer Science, Hardware & Architecture; Computer Science, Software Engineering SC Computer Science GA AX2IJ UT WOS:000346766500022 ER PT J AU Cafasso, DE Nishikawa, C Schneider, P AF Cafasso, D. E. Nishikawa, C. Schneider, P. TI Reinterventions in the superficial femoral artery SO JOURNAL OF CARDIOVASCULAR SURGERY LA English DT Article DE Peripheral arterial disease; Endovascular procedures; Femoral artery; Popliteal artery; Stents ID IN-STENT RESTENOSIS; PACLITAXEL-ELUTING STENTS; CRITICAL LIMB ISCHEMIA; PROXIMAL POPLITEAL ARTERIES; RESILIENT RANDOMIZED-TRIAL; LONG-TERM OUTCOMES; BARE-METAL STENTS; 2-YEAR FOLLOW-UP; BALLOON ANGIOPLASTY; NITINOL STENT AB The management of peripheral arterial disease (PAD) has drastically changed since the introduction and advancement of endovascular surgery The majority of PAD that requires mechanical treatment is managed with endovascular interventions using a variety of techniques and devices. The infrainguinal vasculature, especially the superficial femoral artery (SFA), poses a significant challenge to successful long-term outcomes for a variety of reasons. Because some of these procedures have limited longevity, the management of patients that require reintervention is worthy of special consideration and strategic discussion. This article reviews the risks and failure modes of SFA interventions and the treatment options and techniques for reinterventions. C1 [Cafasso, D. E.] Tripler Army Med Ctr, Dept Gen Surg, Honolulu, HI 96859 USA. [Nishikawa, C.] Univ Hawaii Manoa, John A Burns Sch Med, Honolulu, HI 96822 USA. [Schneider, P.] Dept Vasc Surg, Hawaii Permanente Med Grp, Honolulu, HI USA. RP Schneider, P (reprint author), Kaiser Fdn Hosp, Div Vasc Therapy, 3288 Moanalua Rd, Honolulu, HI 96819 USA. EM peter.schneider@kp.org NR 101 TC 0 Z9 0 U1 0 U2 1 PU EDIZIONI MINERVA MEDICA PI TURIN PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY SN 0021-9509 EI 1827-191X J9 J CARDIOVASC SURG JI J. Cardiovasc. Surg. PD DEC PY 2014 VL 55 IS 6 BP 767 EP 777 PG 11 WC Cardiac & Cardiovascular Systems; Surgery; Peripheral Vascular Disease SC Cardiovascular System & Cardiology; Surgery GA AX3CL UT WOS:000346818100005 PM 25230775 ER PT J AU Hoge, CW Warner, CH AF Hoge, Charles W. Warner, Christopher H. TI Estimating PTSD Prevalence in US Veterans: Considering Combat Exposure, PTSD Checklist Cutpoints, and DSM-5 SO JOURNAL OF CLINICAL PSYCHIATRY LA English DT Editorial Material ID POSTTRAUMATIC-STRESS-DISORDER; COMORBIDITY SURVEY REPLICATION; MENTAL-HEALTH PROBLEMS; IV DISORDERS; IRAQ; AFGHANISTAN; DEPLOYMENT; SERVICE; ONSET C1 [Hoge, Charles W.] Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Warner, Christopher H.] Army Surg Gen & Div Surg, Airborne Div 101, Ft Campbell, KY USA. RP Hoge, CW (reprint author), Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD 20910 USA. EM charles.hoge@us.army.mil NR 18 TC 4 Z9 4 U1 0 U2 7 PU PHYSICIANS POSTGRADUATE PRESS PI MEMPHIS PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA SN 0160-6689 EI 1555-2101 J9 J CLIN PSYCHIAT JI J. Clin. Psychiatry PD DEC PY 2014 VL 75 IS 12 BP E1439 EP E1441 DI 10.4088/JCP.14com09616 PG 3 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA AX3RL UT WOS:000346856500004 PM 25551241 ER PT J AU Seren, HR Keiser, GR Cao, LY Zhang, JD Strikwerda, AC Fan, KB Metcalfe, GD Wraback, M Zhang, X Averitt, RD AF Seren, Huseyin R. Keiser, George R. Cao, Lingyue Zhang, Jingdi Strikwerda, Andrew C. Fan, Kebin Metcalfe, Grace D. Wraback, Michael Zhang, Xin Averitt, Richard D. TI Optically Modulated Multiband Terahertz Perfect Absorber SO ADVANCED OPTICAL MATERIALS LA English DT Article ID METAMATERIAL ABSORBER; DOPED SILICON; FABRICATION; FREQUENCIES; ABSORPTION; TRANSPORT; THZ AB Development of tunable, dynamic, and broad bandwidth metamaterial designs is a keystone objective for metamaterials research, necessary for the future viability of metamaterial optics and devices across the electromagnetic spectrum. Yet, overcoming the inherently localized, narrow bandwidth, and static response of resonant metamaterials continues to be a challenging endeavor. Resonant perfect absorbers have flourished as one of the most promising metamaterial devices with applications ranging from power harvesting to terahertz imaging. Here, an optically modulated resonant perfect absorber is presented. Utilizing photo-excited free carriers in silicon pads placed in the capacitive gaps of split ring resonators, a dynamically modulated perfect absorber is designed and fabricated to operate in reflection. Large modulation depth (38% and 91%) in two absorption bands (with 97% and 92% peak absorption) is demonstrated, which correspond to the LC (0.7 THz) and dipole (1.1 THz) modes of the split ring resonators. C1 [Seren, Huseyin R.; Fan, Kebin; Zhang, Xin] Boston Univ, Dept Mech Engn, Boston, MA 02215 USA. [Keiser, George R.; Cao, Lingyue; Zhang, Jingdi; Averitt, Richard D.] Boston Univ, Dept Phys, Boston, MA 02215 USA. [Strikwerda, Andrew C.] Tech Univ Denmark, Dept Photon Engn, DK-2800 Lyngby, Denmark. [Metcalfe, Grace D.; Wraback, Michael] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Zhang, X (reprint author), Boston Univ, Dept Mech Engn, 110 Cummington Mall, Boston, MA 02215 USA. EM xinz@bu.edu; raveritt@bu.edu RI Zhang, Xin/B-9244-2009; Fan, Kebin/B-2984-2012 OI Zhang, Xin/0000-0002-4413-5084; Fan, Kebin/0000-0002-0275-0871 FU Air Force Office of Scientific Research [FA9550-09-1-0708]; National Science Foundation [ECCS 1309835]; DTRA [W911NF-06-2-0040] FX This work was supported in part by the Air Force Office of Scientific Research under Contract FA9550-09-1-0708, the National Science Foundation under Contract ECCS 1309835, and DTRA under Contract W911NF-06-2-0040 administered by the Army Research Laboratory. The authors also thank Boston University Photonics Center for technical support. NR 45 TC 17 Z9 18 U1 4 U2 67 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 2195-1071 J9 ADV OPT MATER JI Adv. Opt. Mater. PD DEC PY 2014 VL 2 IS 12 BP 1221 EP 1226 DI 10.1002/adom.201400197 PG 6 WC Materials Science, Multidisciplinary; Optics SC Materials Science; Optics GA AW4PA UT WOS:000346261900013 ER PT J AU Aboudara, M Cuadrado, D Docekal, J Hicks, B Mahoney, P AF Aboudara, Matthew Cuadrado, Daniel Docekal, Jeremy Hicks, Brandi Mahoney, Peter TI IMPACT OF PRIMARY BLAST LUNG INJURY DURING COMBAT OPERATIONS IN AFGHANISTAN SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Aboudara, Matthew; Docekal, Jeremy] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Cuadrado, Daniel] Madigan Army Med Ctr, Tacoma, WA 98431 USA. [Hicks, Brandi] William Beaumont Army Med Ctr, El Paso, TX 79920 USA. [Mahoney, Peter] Royal Ctr Def Med, Birmingham, W Midlands, England. NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 EI 1530-0293 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2014 VL 42 IS 12 SU S MA 1055 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA AW3UP UT WOS:000346211801306 ER PT J AU Barnard, E Bebarta, V AF Barnard, Ed Bebarta, Vikhyat TI A MODEL TO PREDICT DURATION OF VENTILATION AND 30-DAY MORTALITY IN PATIENTS WITH TRAUMATIC INJURIES SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Barnard, Ed] Univ Hosp Birmingham NHS Fdn Trust, Barnstaple, England. [Bebarta, Vikhyat] US Army ISR, San Antonio Mil Med Ctr, San Antonio, TX USA. RI Bebarta, Vikhyat/M-1513-2015; bebarta, vikhyat/K-3476-2015 NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 EI 1530-0293 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2014 VL 42 IS 12 SU S MA 379 PG 2 WC Critical Care Medicine SC General & Internal Medicine GA AW3UP UT WOS:000346211800344 ER PT J AU Barrett, R Skabelund, A Morris, M AF Barrett, Rebecca Skabelund, Andrew Morris, Michael TI AORTIC MYCETOMA FROM DISSEMINATED CUNNINGHAMELLA INFECTION SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Barrett, Rebecca] DO, Ft Sam Houston, TX USA. [Skabelund, Andrew] San Antonio Uniformed Serv BAMC, Ft Sam Houston, TX USA. [Morris, Michael] Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 EI 1530-0293 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2014 VL 42 IS 12 SU S MA 1192 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA AW3UP UT WOS:000346211801413 ER PT J AU Bebarta, V AF Bebarta, Vikhyat TI COMPARISON OF PROVIDER TYPES WHO PERFORMED PREHOSPITAL LIFESAVING INTERVENTIONS: A PROSPECTIVE STUDY SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Bebarta, Vikhyat] US Army ISR, San Antonio Mil Med Ctr, San Antonio, TX USA. RI Bebarta, Vikhyat/M-1513-2015; bebarta, vikhyat/K-3476-2015 NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 EI 1530-0293 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2014 VL 42 IS 12 SU S MA 146 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA AW3UP UT WOS:000346211800111 ER PT J AU Belenkiy, S Park, T Baker, W Jordan, B Dubick, M Salinas, J Cancio, L Batchinsky, A AF Belenkiy, Slava Park, Timothy Baker, William Jordan, Bryan Dubick, Michael Salinas, Jose Cancio, Leopoldo Batchinsky, Andriy TI ASSESSING HEMORRHAGE SEVERITY WITH CONTINUOUS AUTOMATIC HEART-RATE-COMPLEXITY MONITORING IN SWINE SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Belenkiy, Slava; Baker, William; Jordan, Bryan; Dubick, Michael; Salinas, Jose; Cancio, Leopoldo; Batchinsky, Andriy] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Park, Timothy] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 EI 1530-0293 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2014 VL 42 IS 12 SU S MA 186 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA AW3UP UT WOS:000346211800151 ER PT J AU Borgman, M Spinella, P Pidcoke, H Cap, A Cannon, J AF Borgman, Matthew Spinella, Philip Pidcoke, Heather Cap, Andrew Cannon, Jeremy TI TRANEXAMIC ACID FOR PEDIATRIC TRAUMA SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Borgman, Matthew] San Antonio Mil Med Ctr, Ft Sm Houston, TX USA. [Spinella, Philip] Washington Univ, St Louis, MO USA. [Cap, Andrew] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Cannon, Jeremy] Brooke Army Med Ctr, San Antonio, TX USA. RI Borgman, Matthew/L-9477-2015 OI Borgman, Matthew/0000-0002-2008-7380 NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 EI 1530-0293 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2014 VL 42 IS 12 SU S MA 1029 PG 2 WC Critical Care Medicine SC General & Internal Medicine GA AW3UP UT WOS:000346211801280 ER PT J AU Dubick, M Scaravilli, V Grubbs, D Cancio, L Batchinsky, A AF Dubick, Michael Scaravilli, Vittorio Grubbs, Dana Cancio, Leopoldo Batchinsky, Andriy TI TISSUE INFLAMMATION IN AWAKE SHEEP SUBJECTED TO EXTRACORPOREAL ACID LOAD CO2 REMOVAL (ALCO2R) SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Dubick, Michael; Scaravilli, Vittorio; Grubbs, Dana; Cancio, Leopoldo] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX USA. [Batchinsky, Andriy] US Army Inst Surg Res, Jbsa Ft San Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 EI 1530-0293 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2014 VL 42 IS 12 SU S MA 683 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA AW3UP UT WOS:000346211800648 ER PT J AU Mann-Salinas, E Caldwell, N Serio-Melvin, M Luellen, D Chung, K Cancio, L Salinas, J AF Mann-Salinas, Elizabeth Caldwell, Nicole Serio-Melvin, Maria Luellen, David Chung, Kevin Cancio, Leopoldo Salinas, Jose TI EVALUATION OF BURN SEPSIS AUTOMATED ALERTS IN AN INTENSIVE CARE UNIT SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Mann-Salinas, Elizabeth; Caldwell, Nicole; Serio-Melvin, Maria; Luellen, David; Chung, Kevin; Cancio, Leopoldo; Salinas, Jose] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 EI 1530-0293 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2014 VL 42 IS 12 SU S MA 981 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA AW3UP UT WOS:000346211801232 ER PT J AU Mondello, S Glass, L Schmid, K Tortella, F AF Mondello, Stefania Glass, Larry Schmid, Kara Tortella, Frank TI CLINICAL UTILITY OF BRAIN INJURY MARKERS IN TBI CLINICAL TRIALS:FINDINGS FROM THE INTREPID2566 TRIAL SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Mondello, Stefania] Univ Messina, Messina, Italy. [Glass, Larry] Neuren Pharmaceut Ltd, Silver Spring, MD USA. [Schmid, Kara; Tortella, Frank] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 EI 1530-0293 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2014 VL 42 IS 12 SU S MA 558 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA AW3UP UT WOS:000346211800523 ER PT J AU Pamplin, J Murray, S Mann-Salinas, E Serio-Melvin, M Huzar, T Wolf, S Nemeth, C AF Pamplin, Jeremy Murray, Sarah Mann-Salinas, Elizabeth Serio-Melvin, Maria Huzar, Todd Wolf, Steven Nemeth, Christopher TI CARD SORTS HELP "UNPACK" CLINICIAN PERSPECTIVES ON PATIENT CONDITION AND TREATMENT PRIORITIES SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Murray, Sarah; Wolf, Steven] US Army Inst Surg Res, San Antonio, TX USA. [Murray, Sarah] Geneva Fdn, San Antonio, TX USA. [Mann-Salinas, Elizabeth; Serio-Melvin, Maria] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Huzar, Todd] Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA. [Nemeth, Christopher] Appl Res Associates Inc, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 EI 1530-0293 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2014 VL 42 IS 12 SU S MA 911 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA AW3UP UT WOS:000346211801162 ER PT J AU Park, T Batchinsky, A Baker, W Belenkiy, S Jordan, B Dubick, M Salinas, J Cancio, L AF Park, Timothy Batchinsky, Andriy Baker, William Belenkiy, Slava Jordan, Bryan Dubick, Michael Salinas, Jose Cancio, Leopoldo TI RESUSCITATIVE ENDOVASCULAR BALLOON OCCLUSION OF THE AORTA IMPROVES SURVIVAL IN LETHAL HEMORRHAGE SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Park, Timothy] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. [Batchinsky, Andriy] US Army, Inst Surg Res, Ft San Houston, TX USA. [Baker, William; Belenkiy, Slava; Jordan, Bryan; Dubick, Michael; Salinas, Jose; Cancio, Leopoldo] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 EI 1530-0293 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2014 VL 42 IS 12 SU S MA 248 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA AW3UP UT WOS:000346211800213 ER PT J AU Salinas, J Waters, J Fenrich, C Serio-Melvin, M Graybill, J Cancio, L Chung, K Stewart, I AF Salinas, Jose Waters, J. Fenrich, Craig Serio-Melvin, Maria Graybill, John Cancio, Leopoldo Chung, Kevin Stewart, Ian TI PREVALENCE OF KIDNEY INJURY IN BURN PATIENTS REQUIRING FLUID RESUSCITATION SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Salinas, Jose; Fenrich, Craig; Serio-Melvin, Maria; Chung, Kevin] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Waters, J.; Graybill, John] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX USA. [Cancio, Leopoldo] US Army Inst Surg Res, San Antonio, TX USA. [Stewart, Ian] San Antonio Mil Med Ctr, Jbsa Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 EI 1530-0293 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2014 VL 42 IS 12 SU S MA 1082 PG 2 WC Critical Care Medicine SC General & Internal Medicine GA AW3UP UT WOS:000346211801333 ER PT J AU Elward, JM Irudayanathan, FJ Nangia, S Chakraborty, A AF Elward, Jennifer M. Irudayanathan, Flaviyan Jerome Nangia, Shikha Chakraborty, Arindam TI Optical Signature of Formation of Protein Corona in the Firefly Luciferase-CdSe Quantum Dot Complex SO JOURNAL OF CHEMICAL THEORY AND COMPUTATION LA English DT Article ID ENERGY-TRANSFER; IN-VIVO; ELECTRONIC-PROPERTIES; SURFACE LIGANDS; DNA INTERACTION; NANOCRYSTALS; NANOMATERIALS; SPECTRA; NANOPARTICLES; CLUSTERS AB Theoretical investigation of protein corona is challenging because of the size of the protein-dot complex. In this work, we have addressed this computational bottleneck by combining pseudopotential + explicitly correlated HartreeFock QM calculations with molecular mechanics, molecular dynamics, and Monte Carlo techniques. The optical gap of a 5 nm CdSe quantum dot (Cd1159Se1183) was computed by sequential addition of luciferase (Lu), and a red shift of 8 nm in the lambda(max) of protein corona (CdSeLu7) was observed. C1 [Elward, Jennifer M.] Army Res Lab, Aberdeen, MD 21005 USA. [Chakraborty, Arindam] Syracuse Univ, Dept Chem, Syracuse, NY 13244 USA. [Irudayanathan, Flaviyan Jerome] Syracuse Univ, Dept Biomed & Chem Engn, Syracuse, NY 13244 USA. [Nangia, Shikha] Syracuse Univ, Syracuse Biomat Inst, Syracuse, NY 13244 USA. RP Nangia, S (reprint author), Syracuse Univ, Syracuse Biomat Inst, Syracuse, NY 13244 USA. EM snangia@syr.edu; archakra@syr.edu FU National Science Foundation [CHE-1349892, ACI-1053575]; Syracuse University FX We thank Professor Mathew Maye for insightful discussions. This research was funded in part by National Science Foundation grant number CHE-1349892 and by Syracuse University. This work used the Extreme Science and Engineering Discovery Environment (XSEDE), which is supported by National Science Foundation grant number ACI-1053575. NR 51 TC 6 Z9 6 U1 2 U2 15 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1549-9618 EI 1549-9626 J9 J CHEM THEORY COMPUT JI J. Chem. Theory Comput. PD DEC PY 2014 VL 10 IS 12 BP 5224 EP 5228 DI 10.1021/ct500681m PG 5 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA AW5OK UT WOS:000346324000002 PM 26583205 ER PT J AU Anderson, B Thimmesch, I Aardsma, N Ed, DMT Carstater, S Schober, J AF Anderson, B. Thimmesch, I. Aardsma, N. Ed, M. Terrell D. Carstater, S. Schober, J. TI The prevalence of abnormal genital findings, vulvovaginitis, enuresis and encopresis in children who present with allegations of sexual abuse SO JOURNAL OF PEDIATRIC UROLOGY LA English DT Article DE Vaginitis; Enuresis; Child abuse; Sexual; Pediatrics; Elimination disorders ID PREPUBERTAL GIRLS; GARDNERELLA-VAGINALIS; NOCTURNAL ENURESIS; ADOLESCENTS; VICTIMS; ASSAULT; SAMPLE AB Objective: To assess the prevalence of vulvovaginitis, enuresis and encopresis in children who were referred for allegations of sexual abuse. Subjects: A retrospective chart review of 1280 children presenting for non-acute examination after allegations of sexual abuse during a 15-year time span. Interview documentation, physical examination documentation, urinalysis, urine and vaginal cultures were reviewed. Results: Of the 1280 children, 73.3% were female and 26.7% male. The ages of the children ranged from 6 months to 18 years (median age was 6 years). Interviews revealed that fondling contact was the most common allegation, followed by oral, vaginal, and anal penetration. Interviews also disclosed lower urinary tract symptoms, UTI, constipation, encopresis and enuresis. Physical examination revealed no abnormal genital findings in 44.7% of cases. Examinations of the vagina noted: erythema (18.1%); hymenal notching (posterior 16.8%, anterior 4.4%); vuvlovaginitis (14.0%); laceration or transection (0.6%); and bruising (0.4%). Examination of the anus noted: anal fissure/tear (14.9%); loss of anal tone (10.6%); reflex anal dilatation (9.2%); venous congestion (3.8%); and proctitis (0.9%). Vulvovaginitis was noted in 14% (131/936) and encopresis in 2.3% (21/936). Enuresis according to age was reported in 13% of 5-9 year olds, 14.7% of 10-16 year olds and 18.2% of 17-18 year olds suspected of being abused. Conclusion: Prevalence of vulvovaginitis and enuresis were increased, and encopresis was decreased in children with allegations of sexual abuse when compared to the general pediatric population. Physicians should continue to be aware of the possibility of the presence of these conditions in children who have been sexually abused, and offer appropriate treatment. (C) 2014 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved. C1 [Anderson, B.; Aardsma, N.; Ed, M. Terrell D.] Lake Erie Coll Osteopath Med, Erie, PA 16509 USA. [Thimmesch, I.] Womack Army Med Ctr, Ft Bragg, NC 28307 USA. [Carstater, S.; Schober, J.] UPMC Hamot, Dept Urol, Erie, PA 16550 USA. [Schober, J.] Rockefeller Univ, Dept Neurobiol & Behav, New York, NY 10065 USA. RP Schober, J (reprint author), 333 State St,Suite 201, Erie, PA 16507 USA. EM oz265@yahoo.com; irthimmesch@gmail.com; naardsma@gmail.com; mterrell@lecom.edu; uropa@aol.com; schobermd@aol.com NR 35 TC 3 Z9 3 U1 0 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1477-5131 EI 1873-4898 J9 J PEDIATR UROL JI J. Pediatr. Urol PD DEC PY 2014 VL 10 IS 6 BP 1216 EP 1221 DI 10.1016/j.jpurol.2014.06.011 PG 6 WC Pediatrics; Urology & Nephrology SC Pediatrics; Urology & Nephrology GA AW6FI UT WOS:000346364600044 PM 25127358 ER PT J AU Zhang, YH Qian, JF Xu, W Russell, SM Chen, XL Nasybulin, E Bhattacharya, P Engelhard, MH Mei, DH Cao, RG Ding, F Cresce, AV Xu, K Zhang, JG AF Zhang, Yaohui Qian, Jiangfeng Xu, Wu Russell, Selena M. Chen, Xilin Nasybulin, Eduard Bhattacharya, Priyanka Engelhard, Mark H. Mei, Donghai Cao, Ruiguo Ding, Fei Cresce, Arthur V. Xu, Kang Zhang, Ji-Guang TI Dendrite-Free Lithium Deposition with Self-Aligned Nanorod Structure SO NANO LETTERS LA English DT Article DE Electrodeposition; Li dendrite; Li nanorods; dendrite free; surface composition ID ELECTROSTATIC SHIELD MECHANISM; VIBRATING ELECTRODE TECHNIQUE; ATOMIC-FORCE MICROSCOPY; LI-ION BATTERIES; METAL BATTERIES; ELECTROCHEMICAL DEPOSITION; NONAQUEOUS ELECTROLYTES; PROPYLENE CARBONATE; SECONDARY BATTERIES; SOLID ELECTROLYTES AB Suppressing lithium (Li) dendrite growth is one of the most critical challenges for the development of Li metal batteries. Here, we report for the first time the growth of dendrite-free lithium films with a self-aligned and highly compacted nanorod structure when the film was deposited in the electrolyte consisting of 1.0 M LiPF6 in propylene carbonate with 0.05 M CsPF6 as an additive. Evolution of both the surface and the cross-sectional morphologies of the Li films during repeated Li deposition/stripping processes were systematically investigated. It is found that the formation of the compact Li nanorod structure is preceded by a solid electrolyte interphase (SEI) layer formed on the surface of the substrate. Electrochemical analysis indicates that an initial reduction process occurred at similar to 2.05 V vs Li/Li+ before Li deposition is responsible for the formation of the initial SEI, while the X-ray photoelectron spectroscopy indicates that the presence of CsPF6 additive can largely enhance the formation of LiF in this initial SEI. Hence, the smooth Li deposition in Cs+-containing electrolyte is the result of a synergistic effect of Cs+ additive and preformed SEI layer. A fundamental understanding on the composition, internal structure, and evolution of Li metal films may lead to new approaches to stabilize the long-term cycling stability of Li metal and other metal anodes for energy storage applications. C1 [Zhang, Yaohui; Qian, Jiangfeng; Xu, Wu; Chen, Xilin; Nasybulin, Eduard; Bhattacharya, Priyanka; Cao, Ruiguo; Ding, Fei; Zhang, Ji-Guang] Pacific NW Natl Lab, Energy & Environm Directorate, Richland, WA 99354 USA. [Engelhard, Mark H.] Pacific NW Natl Lab, Environm & Mol Sci Lab, Richland, WA 99354 USA. [Mei, Donghai] Pacific NW Natl Lab, Fundamental & Computat Sci Directorate, Richland, WA 99354 USA. [Zhang, Yaohui] Harbin Inst Technol, Dept Phys, Harbin 150001, Heilongjiang, Peoples R China. [Qian, Jiangfeng] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China. [Ding, Fei] Tianjin Inst Power Sources, Natl Key Lab Power Sources, Tianjin 300381, Peoples R China. [Russell, Selena M.; Cresce, Arthur V.; Xu, Kang] US Army Res Lab, Sensor & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Xu, W (reprint author), Pacific NW Natl Lab, Energy & Environm Directorate, Richland, WA 99354 USA. EM wu.xu@pnnl.gov; jiguang.zhang@pnnl.gov RI Mei, Donghai/A-2115-2012; Bhattacharya, Priyanka/E-1652-2011; Mei, Donghai/D-3251-2011; Cao, Ruiguo/O-7354-2016; OI Mei, Donghai/0000-0002-0286-4182; Bhattacharya, Priyanka/0000-0003-0368-8480; Engelhard, Mark/0000-0002-5543-0812; Xu, Wu/0000-0002-2685-8684 FU Joint Center for Energy Storage Research, an Energy Innovation Hub - Basic Energy Sciences, Office of Science of the U.S. DOE; DOE's Office of Biological and Environmental Research at PNNL; National Science Foundation of China [21103037]; Linus Pauling Distinguished Postdoctoral Fellowship at PNNL; DOE's Batteries for Advanced Transportation Technologies (DOE-BATT) Program FX The research work conducted at Pacific Northwest National Laboratory (PNNL) was supported by the Joint Center for Energy Storage Research, an Energy Innovation Hub funded by the Basic Energy Sciences, Office of Science of the U.S. DOE. Preliminary work on the dendrite prevention was supported by the Assistant Secretary for Energy Efficiency and Renewable Energy, Office of Vehicle Technology of DOE. The SEM and EDX measurements were performed in the Environmental Molecular Sciences Laboratory, a national scientific user facility sponsored by the DOE's Office of Biological and Environmental Research and located at PNNL. Y.Z. was grateful for the support from the National Science Foundation of China (21103037). P.B. was grateful for support from a Linus Pauling Distinguished Postdoctoral Fellowship at PNNL. The EFM work conducted at the U.S. Army Research Laboratory (ARL) was supported by the DOE's Batteries for Advanced Transportation Technologies (DOE-BATT) Program. S.M.R. was supported by an appointment to the U.S. ARL Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through a cooperative agreement with the U.S. ARL. NR 52 TC 44 Z9 44 U1 48 U2 279 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1530-6984 EI 1530-6992 J9 NANO LETT JI Nano Lett. PD DEC PY 2014 VL 14 IS 12 BP 6889 EP 6896 DI 10.1021/nl5039117 PG 8 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA AW5NY UT WOS:000346322800022 PM 25419865 ER PT J AU Lande, RG AF Lande, R. Gregory TI Stress in Service Members SO PSYCHIATRIC CLINICS OF NORTH AMERICA LA English DT Article DE Military stress; Military culture; Deployment cycle; Alcohol use disorders; Posttraumatic stress disorder; Early interventions; Nonpharmacologic treatment ID MENTAL-HEALTH; MILITARY PERSONNEL; ALCOHOL-USE; NUCLEUS-ACCUMBENS; SUBSTANCE USE; JOB STRESS; DEPLOYMENT; BEHAVIORS; PERFORMANCE; SOLDIERS AB Military service differs from civilian jobs in the stressors that service members experience, including frequent deployments (eg, to an area of combat operations), obedience, regimentation, subordination of self to the group, integrity, and flexibility. The military culture emphasizes teamwork and peer support. In some cases, service members cannot adapt to military life, become overwhelmed by stress, or cannot overcome a traumatic experience. Clinicians should conduct a thorough evaluation guided by an understanding of the military culture. Every effort should be made to identify the stress and the maladaptive response and provide early clinical interventions to prevent progression. C1 [Lande, R. Gregory] US Army, Med Corps, Washington, DC USA. [Lande, R. Gregory] Walter Reed Natl Mil Med Ctr, Dept Psychiat, Psychiat Continu Serv, Bethesda, MD 20889 USA. RP Lande, RG (reprint author), Walter Reed Natl Mil Med Ctr, Dept Psychiat, Psychiat Continu Serv, Bldg 8,4th Floor,8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM Raymond.G.Lande.civ@health.mil NR 39 TC 2 Z9 2 U1 0 U2 8 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0193-953X EI 1558-3147 J9 PSYCHIAT CLIN N AM JI Psychiatr. Clin. North Amer. PD DEC PY 2014 VL 37 IS 4 BP 547 EP + DI 10.1016/j.psc.2014.08.007 PG 15 WC Psychiatry SC Psychiatry GA AX0CB UT WOS:000346620000006 PM 25455065 ER PT J AU Bryan, Z Bryan, I Gaddy, BE Reddy, P Hussey, L Bobea, M Guo, W Hoffmann, M Kirste, R Tweedie, J Gerhold, M Irving, DL Sitar, Z Collazo, R AF Bryan, Zachary Bryan, Isaac Gaddy, Benjamin E. Reddy, Pramod Hussey, Lindsay Bobea, Milena Guo, Wei Hoffmann, Marc Kirste, Ronny Tweedie, James Gerhold, Michael Irving, Douglas L. Sitar, Zlatko Collazo, Ramon TI Fermi level control of compensating point defects during metalorganic chemical vapor deposition growth of Si-doped AlGaN SO APPLIED PHYSICS LETTERS LA English DT Article ID SEMICONDUCTORS; GAN AB A Fermi-level control scheme for point defect management using above-bandgap UV illumination during growth is presented. We propose an extension to the analogy between the Fermi level and the electrochemical potential such that the electrochemical potential of a charged defect in a material with steady-state populations of free charge carriers may be expressed in terms of the quasi-Fermi levels. A series of highly Si-doped Al0.65Ga0.35N films grown by metalorganic chemical vapor deposition with and without UV illumination showed that samples grown under UV illumination had increased free carrier concentration, free carrier mobility, and reduced midgap photoluminescence all indicating a reduction in compensating point defects. (c) 2014 AIP Publishing LLC. C1 [Bryan, Zachary; Bryan, Isaac; Gaddy, Benjamin E.; Reddy, Pramod; Hussey, Lindsay; Bobea, Milena; Guo, Wei; Hoffmann, Marc; Kirste, Ronny; Tweedie, James; Irving, Douglas L.; Sitar, Zlatko; Collazo, Ramon] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Gerhold, Michael] Army Res Off, Engn Sci Directorate, Res Triangle Pk, NC 27703 USA. RP Bryan, Z (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. OI Reddy, Pramod/0000-0002-8556-1178 FU NSF [DMR-1108071, DMR-1312582]; ARO [W911NF-04-D-0003]; ARPA-E [DE-AR0000299]; GAANN Fellowship; NDSEG Fellowship FX Partial financial support from NSF (DMR-1108071 and DMR-1312582), ARO (W911NF-04-D-0003), ARPA-E (DE-AR0000299), GAANN Fellowship, and NDSEG Fellowship was greatly appreciated. NR 21 TC 10 Z9 10 U1 7 U2 42 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD DEC 1 PY 2014 VL 105 IS 22 AR 222101 DI 10.1063/1.4903058 PG 4 WC Physics, Applied SC Physics GA AW4QH UT WOS:000346265200037 ER PT J AU Papa, L LaMee, A Tan, CN Hill-Pryor, C AF Papa, Linda LaMee, Alexander Tan, Ciara N. Hill-Pryor, Crystal TI Systematic Review and Meta-Analysis of Noninvasive Cranial Nerve Neuromodulation for Nervous System Disorders SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Review DE Ataxia; Brain injuries; Gait; Magnetic resonance imaging; Nervous system; Neuronal plasticity; Postural balance; Rehabilitation; Rehabilitation, brain injuries; Trauma; Vertigo ID DEEP BRAIN-STIMULATION; ELECTRICAL TONGUE STIMULATION; MAJOR DEPRESSIVE EPISODES; PARKINSONS-DISEASE; SUBTHALAMIC NUCLEUS; NEUROPLASTICITY; REHABILITATION; EFFICACY; VNS; MODALITIES AB Objective: To systematically review the medical literature and comprehensively summarize clinical research done on rehabilitation with a novel portable and noninvasive electrical stimulation device called the cranial nerve noninvasive neuromodulator in patients suffering from nervous system disorders. Data Sources: PubMed, MEDLINE, and Cochrane Database of Systematic Reviews from 1966 to March 2013. Study Selection: Studies were included if they recruited adult patients with peripheral and central nervous system disorders, were treated with the cranial nerve noninvasive neuromodulator device, and were assessed with objective measures of function. Data Extraction: After title and abstract screening of potential articles, full texts were independently reviewed to identify articles that met inclusion criteria. Data Synthesis: The search identified 12 publications: 5 were critically reviewed, and of these 5, 2 were combined in a meta-analysis. There were no randomized controlled studies identified, and the meta-analysis was based on pre-post studies. Most of the patients were individuals with a chronic balance dysfunction. The pooled results demonstrated significant improvements in the dynamic gait index postintervention with a mean difference of 3.45 (95% confidence interval, 1.75-5.15; P<.001), Activities-specific Balance Confidence scale with a mean difference of 16.65 (95% confidence interval, 7.65-25.47; P<.001), and Dizziness Handicap Inventory with improvements of 26.07 (95% confidence interval, -35.78 to -16.35; P<.001). Included studies suffered from small sample sizes, lack of randomization, absence of blinding, use of referral populations, and variability in treatment schedules and follow-up rates. Conclusions: Given these limitations, the results of the meta-analysis must be interpreted cautiously. Further investigation using rigorous randomized controlled trials is needed to evaluate this promising rehabilitation tool for nervous system disorders. (C) 2014 by the American Congress of Rehabilitation Medicine C1 [Papa, Linda; Tan, Ciara N.] Orlando Reg Med Ctr Inc, Dept Emergency Med, Orlando, FL 32806 USA. [LaMee, Alexander] Univ Cent Florida, Dept Biomed Sci, Orlando, FL 32816 USA. [Hill-Pryor, Crystal] US Army, Med Res & Mat Command, Combat Casualty Care Res Program, Ft Detrick, MD USA. RP Papa, L (reprint author), Orlando Reg Med Ctr Inc, Dept Emergency Med, 86 W Underwood S-200, Orlando, FL 32806 USA. EM lpstat@aol.com NR 40 TC 0 Z9 0 U1 2 U2 12 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0003-9993 EI 1532-821X J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD DEC PY 2014 VL 95 IS 12 BP 2435 EP 2443 DI 10.1016/j.apmr.2014.04.018 PG 9 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA AW0AY UT WOS:000345954000027 PM 24814561 ER PT J AU Griggs, CS Barber, PS Kelley, SP Moser, RD Seiter, JM Thomas, CC Coleman, JG Medina, VF Rogers, RD AF Griggs, C. S. Barber, P. S. Kelley, S. P. Moser, R. D. Seiter, J. M. Thomas, C. C. Coleman, J. G. Medina, V. F. Rogers, R. D. TI Biomimetic Mineralization of Uranium by Metabolically-Inactive Shrimp Shell SO CRYSTAL GROWTH & DESIGN LA English DT Article ID AMORPHOUS CALCIUM-CARBONATE; BIOMINERALIZATION; HYDROXYAPATITE; SOLUBILITY; CHEMISTRY; CRAYFISH; SORPTION; SYSTEMS; SOILS AB Biomineralization in crustaceans is a remarkably efficient process of ion transport and phase transformation in a spatial template. Here we show the use of this preorganized pathway with waste shrimp shell as both a phosphate source and template for the mineralization of UO22+ to uramphite. By using the physical structural and chemical reservoir of the biogenic platform, the only requirement was to develop a solution for ion supply. Hydroxylammonium acetate, an amphiprotic salt parallel to the amine and carboxylic acid motif pervasive in biomolecules, was prepared and used for the delivery of dissolved uranyl ions into the spatial constraints of the exoskeleton. Although biomediated phase transformations of exogenous metals is typically limited to living organisms, our results show that metabolically inactive shrimp shells are adaptive and responsive toward a nonessential ion. This suggests the nonliving exoskeleton may provide rapid bottom-up assembly routes to technologically important new inorganic crystalline materials. C1 [Griggs, C. S.; Barber, P. S.; Kelley, S. P.; Rogers, R. D.] Univ Alabama, Ctr Green Mfg, Tuscaloosa, AL 35487 USA. [Griggs, C. S.; Barber, P. S.; Kelley, S. P.; Rogers, R. D.] Univ Alabama, Dept Chem, Tuscaloosa, AL 35487 USA. [Griggs, C. S.; Moser, R. D.; Seiter, J. M.; Thomas, C. C.; Coleman, J. G.; Medina, V. F.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Griggs, C. S.; Moser, R. D.; Seiter, J. M.; Thomas, C. C.; Coleman, J. G.; Medina, V. F.] US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. RP Rogers, RD (reprint author), Univ Alabama, Ctr Green Mfg, Tuscaloosa, AL 35487 USA. EM rdrogers@ua.edu OI Rogers, Robin D./0000-0001-9843-7494 FU DOE Office of Nuclear Energy Nuclear Energy University Programs [DE-NE0000672]; Environmental Security Technology Certification Program (ESTCP) [ER-201321]; U.S. Department of Energy (DOE), Geosciences [DE-FG02-92ER14244]; DOE, Office of Science, Office of Basic Energy Sciences [DE-AC02-98CH10886] FX The UA authors would like to thank the DOE Office of Nuclear Energy Nuclear Energy University Programs grant #DE-NE0000672 for support of this work. Additional research support was provided by the Environmental Security Technology Certification Program (ESTCP) project ER-201321. The authors also thank the Gulf Coast Agricultural and Seafood Cooperative in Bayou La Batre, AL for providing the shrimp shell. Portions of this work were performed at Beamline X27A, National Synchrotron Light Source (NSLS), Brookhaven National Laboratory. X27A is supported in part by the U.S. Department of Energy (DOE), Geosciences (DE-FG02-92ER14244 to The University of Chicago-CARS). Use of the NSLS was supported by the DOE, Office of Science, Office of Basic Energy Sciences, under Contract No. DE-AC02-98CH10886. NR 30 TC 4 Z9 4 U1 3 U2 29 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1528-7483 EI 1528-7505 J9 CRYST GROWTH DES JI Cryst. Growth Des. PD DEC PY 2014 VL 14 IS 12 BP 6172 EP 6176 DI 10.1021/cg5015576 PG 5 WC Chemistry, Multidisciplinary; Crystallography; Materials Science, Multidisciplinary SC Chemistry; Crystallography; Materials Science GA AU9AJ UT WOS:000345884000003 ER PT J AU Armanious, MMH Olaya, SVB Tyo, JS Skipper, MC Abdalla, MD Altgilbers, LL Bryan, A AF Armanious, Miena M. H. Olaya, Sandra V. Bernal Tyo, J. Scott Skipper, Michael C. Abdalla, Michael D. Altgilbers, Larry L. Bryan, Austen TI An Electrically Small Conical Folded Dipole Antenna for Use as a Compact, Self-Resonant Mesoband High-Power Microwave Source SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Article DE Antennas; high power microwaves ID WIDE-BAND SOURCE AB Mesoband (MB) high-power microwave (HPM) sources use fast-risetime switches to trigger weak resonators in order to create a damped sinusoidal waveform. MB sources are more compact and less complicated than narrowband HPM sources, and they possess increased energy spectral density per pulse relative to ultrawideband HPM sources. In this paper we consider the design of a MB HPM system that operates at the low end of the VHF spectrum (below 50 MHz) that is based on a self-resonant, electrically small antenna (ESA). The ESA is based on a conical folded helix design. It is slowly charged up to high voltage, and it is then switched using a fast-rise time switch to convert the stored static energy into radiated electromagnetic fields. Here we show the design, modeling, and preliminary experimental results of the source operating as low as 38 MHz at an electrical size of, where is the radius of a sphere circumscribing the source. Experimental results are obtained in the far field for a charge voltage of 30 kV. C1 [Armanious, Miena M. H.; Olaya, Sandra V. Bernal; Tyo, J. Scott] Univ Arizona, Ctr Opt Sci, Tucson, AZ 85721 USA. [Skipper, Michael C.; Abdalla, Michael D.] ASR Corp, Albuquerque, NM 87131 USA. [Altgilbers, Larry L.] US Army Space & Missile Def Command, Huntsville, AL 35807 USA. [Bryan, Austen] Missile Def Agcy, Albuquerque, NM 87117 USA. RP Armanious, MMH (reprint author), Univ Arizona, Ctr Opt Sci, Tucson, AZ 85721 USA. EM tyo@ieee.org FU STTR Contract from the Missile Defense Agency FX This work was supported by a Phase I/Phase II STTR Contract from the Missile Defense Agency. NR 18 TC 3 Z9 3 U1 0 U2 9 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-926X EI 1558-2221 J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD DEC PY 2014 VL 62 IS 12 BP 5960 EP 5967 DI 10.1109/TAP.2014.2360549 PG 8 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA AU8LY UT WOS:000345849100003 ER PT J AU Talladay, TG Templeton, DW AF Talladay, Timothy G. Templeton, Douglas W. TI Glass Armor - An Overview SO INTERNATIONAL JOURNAL OF APPLIED GLASS SCIENCE LA English DT Article ID TRANSPARENT; CERAMICS AB Transparent armor for military vehicles has recently gained renewed attention. However the ballistic impact and penetration processes of glass armors are not well understood. Different types of glasses exhibit different ballistic responses, and a pressing need exists to better comprehend and model these responses in order to develop lightweight armors. The need to better understand the processes of densification and dynamic fracture and the need for input and validation data for continuum models are highlighted as examples. C1 [Talladay, Timothy G.; Templeton, Douglas W.] US Army Tank Automot Res Dev & Engn Ctr, Warren, MI 48397 USA. RP Talladay, TG (reprint author), US Army Tank Automot Res Dev & Engn Ctr, Warren, MI 48397 USA. EM timothy.g.talladay.civ@mail.mil NR 19 TC 1 Z9 1 U1 4 U2 18 PU WILEY PERIODICALS, INC PI SAN FRANCISCO PA ONE MONTGOMERY ST, SUITE 1200, SAN FRANCISCO, CA 94104 USA SN 2041-1286 EI 2041-1294 J9 INT J APPL GLASS SCI JI Int. J. Appl. Glass Sci. PD DEC PY 2014 VL 5 IS 4 SI SI BP 331 EP 333 DI 10.1111/ijag.12096 PG 3 WC Materials Science, Ceramics SC Materials Science GA AW0MY UT WOS:000345987800002 ER PT J AU Swab, JJ Patel, PJ Tran, X Gilde, L Luoto, E Gaviola, MH Gott, A Paulson, B Kilczewski, S AF Swab, Jeffrey J. Patel, Parimal J. Tran, Xuan Gilde, Luke Luoto, Ernest Gaviola, Mariel H. Gott, Ashley Paulson, Blake Kilczewski, Steven TI Equibiaxial Flexure Strength of Glass: Influence of Glass Plate Size and Equibiaxial Ring Ratio SO INTERNATIONAL JOURNAL OF APPLIED GLASS SCIENCE LA English DT Article ID FLOAT GLASS; DYNAMIC FATIGUE; SILICA GLASS; COATINGS; SURFACES; STRESS AB Glass plays an important role in many engineering applications including transparent armor. Determining the actual strength of a glass is problematic because typical glass strength numbers are presented in the literature as ranges. Minor changes in surface finish, composition, test method employed, and processing all influence the mechanical strength of glass. A standardized method needs to be utilized to ensure that strength data can be compared universally. The use of a standard methodology is vital when comparing glass compositions or multiple sample lots of the same composition in order to attribute any real strength variations to the glass itself. While the procedures established in ASTM C1499 provide a good framework for glass strength measurement, flexibility in the experimental parameters of the standard allow for substantial strength variations when testing glass materials. The ratio between the load and support ring diameters, as well as the specimen dimensions, is shown to lead to variations in both the measured strength, as well as the number of valid/invalid tests based on where fracture initiates. The goal of this study is to quantify these effects in order to establish optimized testing conditions for determining the strength of float glass. C1 [Swab, Jeffrey J.; Patel, Parimal J.; Tran, Xuan; Gilde, Luke; Luoto, Ernest; Gaviola, Mariel H.; Gott, Ashley; Paulson, Blake; Kilczewski, Steven] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Tran, Xuan; Gaviola, Mariel H.] Aberdeen High Sch, Sci & Math Acad, Senior Capstone Project, Aberdeen, MD USA. [Luoto, Ernest] Cecil Cty Community Coll, Elkton, MD 21921 USA. [Gott, Ashley] Univ Maryland, College Pk, MD USA. [Paulson, Blake] Harford Community Coll, Churchville, MD USA. RP Swab, JJ (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM jeffrey.j.swab.civ@mail.mil FU USARL; US Department of Energy FX Work performed through support by an appointment to the Research Participation Program at the US Army Research Laboratory (USARL) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between USARL and the US Department of Energy. NR 19 TC 2 Z9 2 U1 0 U2 5 PU WILEY PERIODICALS, INC PI SAN FRANCISCO PA ONE MONTGOMERY ST, SUITE 1200, SAN FRANCISCO, CA 94104 USA SN 2041-1286 EI 2041-1294 J9 INT J APPL GLASS SCI JI Int. J. Appl. Glass Sci. PD DEC PY 2014 VL 5 IS 4 SI SI BP 384 EP 392 DI 10.1111/ijag.12094 PG 9 WC Materials Science, Ceramics SC Materials Science GA AW0MY UT WOS:000345987800008 ER PT J AU Coleman, LS Ford, WM Dobony, CA Britzke, ER AF Coleman, Laci S. Ford, W. Mark Dobony, Chris A. Britzke, Eric R. TI A Comparison of Passive and Active Acoustic Sampling for a Bat Community Impacted by White-Nose Syndrome SO JOURNAL OF FISH AND WILDLIFE MANAGEMENT LA English DT Article DE acoustics; active sampling; bats; detection probability; occupancy analysis; passive sampling ID ECHOLOCATION CALLS; MYOTIS-SODALIS; OCCUPANCY; DETECTORS; IDENTIFICATION; INVENTORY; PROTOCOL; FOREST; RATES AB In the summers of 2011 and 2012, we compared passive and active acoustic sampling for bats at 31 sites at Fort Drum Military Installation, New York. We defined active sampling as acoustic sampling that occurred in 30-min intervals between the hours of sunset and 0200 with a user present to manipulate the directionality of the microphone. We defined passive sampling as acoustic sampling that occurred over a 12-h period (1900-0700 hours) without a user present and with the microphone set in a predetermined direction. We detected seven of the nine possible species at Fort Drum, including the federally endangered Indiana bat Myotis sodalis, the proposed-for-listing northern bat M. septentrionalis, the little brown bat M. lucifugus, and the big brown bat Eptesicus fuscus, which are impacted by white-nose syndrome (WNS); and the eastern red bat Lasiurus borealis, the hoary bat L. cinereus, and the silver-haired bat Lasionycteris noctivagans, which are not known to be impacted by WNS. We did not detect two additional WNS-impacted species known to historically occur in the area: the eastern small-footed bat Myotis leibii and the tri-colored bat Perimyotis subflavus. Single-season occupancy models revealed lower detection probabilities of all detected species using active sampling versus passive sampling. Additionally, overall detection probabilities declined in detected WNS-impacted species between years. A paired t-test of simultaneous sampling on 21 occasions revealed that overall recorded foraging activity per hour was greater using active than passive sampling for big brown bats and greater using passive than active sampling for little brown bats. There was no significant difference in recorded activity between methods for other WNS-impacted species, presumably because these species have been so reduced in number that their "apparency" on the landscape is lower. Finally, a cost analysis of standard passive and active sampling protocols revealed that passive sampling is substantially more cost-effective than active sampling per hour of data collection. We recommend passive sampling over active sampling methodologies as they are defined in our study for detection probability and/or occupancy studies focused on declining bat species in areas that have experienced severe WNS-associated impacts. C1 [Coleman, Laci S.] Virginia Polytech Inst & State Univ, Dept Fisheries & Wildlife Conservat, Blacksburg, VA 24061 USA. [Ford, W. Mark] Virginia Polytech Inst & State Univ, Dept Fisheries & Wildlife Conservat, Virginia Cooperat Fish & Wildlife Res Unit, US Geol Survey, Blacksburg, VA 24061 USA. [Dobony, Chris A.] Ft Drum Mil Installat, Nat Resources Branch, Ft Drum, NY 13602 USA. [Britzke, Eric R.] US Army Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Ford, WM (reprint author), Virginia Polytech Inst & State Univ, Dept Fisheries & Wildlife Conservat, Virginia Cooperat Fish & Wildlife Res Unit, US Geol Survey, 106 Cheatham Hall, Blacksburg, VA 24061 USA. EM wmford@vt.edu FU Fort Drum Natural Resources Branch through National Park Service, Southern Appalachian Cooperative Ecosystem Study Unit [W9126G-11-2-SOI-0029]; U.S. Geological Survey Cooperative Research Unit Research Work Order [VA-RWO-142] FX Funding for this study was provided by the Fort Drum Natural Resources Branch through National Park Service, Southern Appalachian Cooperative Ecosystem Study Unit contract W9126G-11-2-SOI-0029 and the U.S. Geological Survey Cooperative Research Unit Research Work Order VA-RWO-142. We thank R. Rainbolt, A. Dale, S. Dedrick, G. Luongo, and N. Grosse for field assistance. Earlier drafts of this manuscript were reviewed by D. Stauffer and J.B. Johnson. Additionally, this manuscript received helpful peer review from the Subject Editor and two anonymous reviewers. NR 38 TC 1 Z9 3 U1 9 U2 265 PU U S FISH & WILDLIFE SERVICE PI SHEPHERDSTOWN PA NATL CONSERVATION TRAINING CENTER, CONSERVATION LIBRARY, 698 CONSERVATION WAY, SHEPHERDSTOWN, WV 25443 USA SN 1944-687X J9 J FISH WILDL MANAG JI J. Fish Wildl. Manag. PD DEC PY 2014 VL 5 IS 2 BP 217 EP 226 DI 10.3996/082103-JFWM-057 PG 10 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA AW1MA UT WOS:000346052300003 ER PT J AU Neiman, PJ Gottas, DJ White, AB Schick, LJ Ralph, FM AF Neiman, Paul J. Gottas, Daniel J. White, Allen B. Schick, Lawrence J. Ralph, F. Martin TI The Use of Snow-Level Observations Derived from Vertically Profiling Radars to Assess Hydrometeorological Characteristics and Forecasts over Washington's Green River Basin SO JOURNAL OF HYDROMETEOROLOGY LA English DT Article DE Hydrometeorology; Orographic effects; Radars; Radar observations; Wind profilers; Forecast verification; skill ID ATMOSPHERIC RIVERS; PACIFIC-NORTHWEST; MELTING LAYER; SIERRA-NEVADA; OROGRAPHIC PRECIPITATION; NORTHERN CALIFORNIA; MOUNTAIN SNOWPACK; SATELLITE; COAST; FLOW AB Two vertically pointing S-band radars (coastal and inland) were operated in western Washington during two winters to monitor brightband snow-level altitudes. Similar snow-level characteristics existed at both sites, although the inland site exhibited lower snow levels by similar to 70 m because of proximity to cold continental air, and snow-level altitude changes were delayed there by several hours owing to onshore translation of weather systems. The largest precipitation accumulations and rates occurred when the snow level was largely higher than the adjacent terrain. A comparison of these observations with long-term operational radiosonde data reveals that the radar snow levels mirrored climatological conditions. The inland radar data were used to assess the performance of nearby operational freezing-level forecasts. The forecasts possessed a lower-than-observed bias of 100-250 m because of a combination of forecast error and imperfect representativeness between the forecast and observing points. These forecast discrepancies increased in magnitude with higher observed freezing levels, thus representing the hydrologically impactful situations where a greater fraction of mountain basins receive rain rather than snow and generate more runoff than anticipated. Vertical directional wind shear calculations derived from wind-profiler data, and concurrent surface temperature data, reveal that most snow-level forecast discrepancies occurred with warm advection aloft and low-level cold advection through the Stampede Gap. With warm advection, forecasts were too high (low) for observed snow levels below (above) 1.25 km MSL. An analysis of sea level pressure differences across the Cascades indicated that mean forecasts were too high (low) for observed snow levels below (above) 1.25 km MSL when higher pressure was west (east) of the range. C1 [Neiman, Paul J.; Gottas, Daniel J.; White, Allen B.] NOAA ESRL Phys Sci Div, Boulder, CO 80305 USA. [Schick, Lawrence J.] US Army Corps Engineers, Seattle, WA USA. [Ralph, F. Martin] Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 USA. RP Neiman, PJ (reprint author), NOAA ESRL Phys Sci Div, 325 Broadway, Boulder, CO 80305 USA. EM paul.j.neiman@noaa.gov FU NOAA/ESRL/PSD; NOAA FX This study benefited greatly from the support of the talented engineering and technical team at NOAA/ESRL/PSD; they built, deployed, and maintained the radars used in this study. In particular, we acknowledge James Jordan and Clark King for managing the staff and field deployments. We thank the city of Westport, WA, for providing a radar site there. We also thank Pierce County and the city of Tacoma/Tacoma Water for providing the Ravensdale radar site. This work was supported by NOAA's Hydrometeorological Testbed program and Office of Oceanic and Atmospheric Research, by the NWS Office of Science and Technology, and by the NWS Office of Hydrologic Development. We are grateful for the comments and suggestions offered by two anonymous reviewers. Their efforts improved the scope and quality of this study. NR 41 TC 1 Z9 1 U1 1 U2 7 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1525-755X EI 1525-7541 J9 J HYDROMETEOROL JI J. Hydrometeorol. PD DEC PY 2014 VL 15 IS 6 BP 2522 EP 2541 DI 10.1175/JHM-D-14-0019.1 PG 20 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA AU9FZ UT WOS:000345898400024 ER PT J AU Suffczynski, P Crone, NE Franaszczuk, PJ AF Suffczynski, Piotr Crone, Nathan E. Franaszczuk, Piotr J. TI Afferent inputs to cortical fast-spiking interneurons organize pyramidal cell network oscillations at high-gamma frequencies (60-200 Hz) SO JOURNAL OF NEUROPHYSIOLOGY LA English DT Article DE cortex; high-gamma; model; oscillations ID LOCAL-FIELD POTENTIALS; PRIMARY VISUAL-CORTEX; SOMATOSENSORY CORTEX; INHIBITORY INTERNEURONS; ELECTRICAL SYNAPSES; MOTOR CORTEX; NEURONS; HIPPOCAMPUS; MECHANISMS; NEOCORTEX AB High-gamma activity, ranging in frequency between similar to 60 Hz and 200 Hz, has been observed in local field potential, electrocorticography, EEG and magnetoencephalography signals during cortical activation, in a variety of functional brain systems. The origin of these signals is yet unknown. Using computational modeling, we show that a cortical network model receiving thalamic input generates high-gamma responses comparable to those observed in local field potential recorded in monkey somatosensory cortex during vibrotactile stimulation. These high-gamma oscillations appear to be mediated mostly by an excited population of inhibitory fast-spiking interneurons firing at high-gamma frequencies and pacing excitatory regular-spiking pyramidal cells, which fire at lower rates but in phase with the population rhythm. The physiological correlates of high-gamma activity, in this model of local cortical circuits, appear to be similar to those proposed for hippocampal ripples generated by subsets of interneurons that regulate the discharge of principal cells. C1 [Suffczynski, Piotr] Univ Warsaw, Inst Expt Phys, Dept Biomed Phys, PL-02093 Warsaw, Poland. [Suffczynski, Piotr; Crone, Nathan E.; Franaszczuk, Piotr J.] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA. [Franaszczuk, Piotr J.] US Army, Res Lab, Human Res & Engn Directorate, Aberdeen, MD USA. RP Suffczynski, P (reprint author), Univ Warsaw, Inst Expt Phys, Dept Biomed Phys, Pasteura 5, PL-02093 Warsaw, Poland. EM suffa@fuw.edu.pl RI Franaszczuk, Piotr/B-6532-2008 OI Franaszczuk, Piotr/0000-0002-5166-4224 FU National Institute of Neurological Disorders and Stroke [NS-40596]; Kosciuszko Foundation FX This work was supported by National Institute of Neurological Disorders and Stroke Grant NS-40596. P. Suffczynski was partly sponsored by a fellowship from the Kosciuszko Foundation. NR 58 TC 5 Z9 5 U1 0 U2 13 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-3077 EI 1522-1598 J9 J NEUROPHYSIOL JI J. Neurophysiol. PD DEC 1 PY 2014 VL 112 IS 11 BP 3001 EP 3011 DI 10.1152/jn.00844.2013 PG 11 WC Neurosciences; Physiology SC Neurosciences & Neurology; Physiology GA AW1AN UT WOS:000346023000025 PM 25210164 ER PT J AU Childs, JD Harman, JS Rodeghero, JR Horn, M George, SZ AF Childs, John D. Harman, Jeffrey S. Rodeghero, Jason R. Horn, Maggie George, Steven Z. TI Implications of Practice Setting on Clinical Outcomes and Efficiency of Care in the Delivery of Physical Therapy Services SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE cost; health services research; hospital; private practice; rehabilitation ID COMPUTERIZED ADAPTIVE TEST; LOW-BACK-PAIN; RESPONSIVE MEASURES; KNEE IMPAIRMENTS; COSTS; VALIDITY; EPISODES; HIP AB STUDY DESIGN: Retrospective analysis of episodes of care. OBJECTIVE: To assess the implications of practice setting (hospital outpatient settings versus private practice) on clinical outcomes and efficiency of care in the delivery of physical therapy services. BACKGROUND: Many patients with musculoskeletal conditions benefit from care provided by physical therapists. The majority of physical therapists deliver services in either a private practice setting or in a hospital outpatient setting. There have not been any recent studies comparing whether clinical outcomes or efficiency of care differ based on practice setting. METHODS: Practices that use the Focus On Therapeutic Outcomes, Inc system were surveyed to determine the specific type of setting in which outcomes were collected in patients with musculoskeletal impairments. Patient outcome data over 12 months (2011-2012) were extracted from the database and analyzed to identify differences in the functional status achieved and the efficiency of the care delivery process between private practices and hospital outpatient settings. RESULTS: The data suggest that patients experience more efficient care when receiving physical therapy in hospital outpatient settings compared to private practice settings, as demonstrated by 3.1 points of greater improvement in functional status over 2.9 fewer physical therapy visits. However, the difference in improvement between settings is less than the minimum clinically important difference of 9 points in functional status outcome score. CONCLUSION: In this cohort, our data suggest that more efficient care was delivered in the hospital outpatient setting compared to the private practice setting. However, we cannot conclude that care delivered in the hospital setting is more cost-effective, because it is possible that any difference in efficiency of care favoring the hospital outpatient setting is more than offset by higher costs of care. C1 [Childs, John D.] Baylor Univ, US Army, Doctoral Program Phys Therapy, Ft Sam Houston, TX USA. [Harman, Jeffrey S.] Univ Florida, Coll Publ Hlth & Hlth Profess, Dept Hlth Serv Res Management & Policy, Gainesville, FL USA. [Rodeghero, Jason R.] OSF St James John W Albrecht Med Ctr, Pontiac, IL USA. [Horn, Maggie] Langston Univ, Sch Phys Therapy, Langston, OK USA. [George, Steven Z.] Univ Florida, Ctr Pain Res & Behav Treatment, Dept Phys Therapy, Gainesville, FL USA. RP Childs, JD (reprint author), Evidence Mot, 17325 Bell North Dr,Suite 2B, Schertz, TX 78154 USA. EM childsjd@gmail.com NR 33 TC 4 Z9 4 U1 0 U2 4 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD DEC PY 2014 VL 44 IS 12 BP 955 EP 963 DI 10.2519/jospt.2014.5224 PG 9 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA AW2IR UT WOS:000346111900006 PM 25350133 ER PT J AU Moore, N Altman, DE Vuong, CV Sousa, JC Marcsisin, SR Zottig, VE Genovese, RF AF Moore, Nicole Altman, Daniel E. Vuong, Chau V. Sousa, Jason C. Marcsisin, Sean R. Zottig, Victor E. Genovese, Raymond F. TI Developmental Status Shapes Physiological and Behavioral Responses to Traumatic Stress Exposures in Male Rats SO NEUROPSYCHOPHARMACOLOGY LA English DT Meeting Abstract CT 53rd Annual Meeting of the American-College-of-Neuropsychopharmacology (ACNP) CY DEC 07-11, 2014 CL Phoenix, AZ SP Amer Coll Neuropsychopharmacol DE Adolescence; Traumatic stress; Neuroendocrine; Behavior C1 [Moore, Nicole; Altman, Daniel E.; Vuong, Chau V.; Sousa, Jason C.; Marcsisin, Sean R.; Zottig, Victor E.; Genovese, Raymond F.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0893-133X EI 1740-634X J9 NEUROPSYCHOPHARMACOL JI Neuropsychopharmacology PD DEC PY 2014 VL 39 SU 1 MA M34 BP S132 EP S133 PG 2 WC Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA AU9IJ UT WOS:000345905000242 ER PT J AU Ghebrebrhan, M Hoke, LC Aranda, FJ Hoey, ML Archambault, DM Perry, J Belton, L Ziegler, D Carlson, JB Kimball, BR AF Ghebrebrhan, Michael Hoke, Landa C. Aranda, Francisco J. Hoey, Megan L. Archambault, Deana M. Perry, Jeffrey Belton, Lauren Ziegler, David Carlson, Joel B. Kimball, Brian R. TI Design and fabrication of extruded retroreflective polymer fibers SO OPTICAL MATERIALS EXPRESS LA English DT Article ID TEXTILES; SHAPE AB Extruded polymer fibers with submillimeter diameters are considered for tailored optical and near-IR properties. Retroreflection of light is demonstrated. Simulated and measured reflection spectra are compared and found to agree. Additional simulations suggest that retroreflection from gold coated 12-pointed star fibers could exceed retroreflection from microbeads on t-shirt. Finally, a novel, robust, extruded retroreflective fiber with performance approaching microbeads is presented. (C) 2014 Optical Society of America C1 [Ghebrebrhan, Michael; Hoke, Landa C.; Aranda, Francisco J.; Hoey, Megan L.; Archambault, Deana M.; Belton, Lauren; Ziegler, David; Carlson, Joel B.; Kimball, Brian R.] US Army, Fiber & Mat Phys Div, Natick Soldier Res Engn & Dev Ctr, Natick, MA 01760 USA. [Perry, Jeffrey] US Navy, Clothing & Text Res Facil, Natick, MA 01760 USA. RP Ghebrebrhan, M (reprint author), US Army, Fiber & Mat Phys Div, Natick Soldier Res Engn & Dev Ctr, Natick, MA 01760 USA. EM michael.ghebrebrhan2.ctr@mail.mil FU U.S. Army Natick Soldier Research, Development, and Engineering Center; U.S. Department of Energy; NSRDEC FX The authors would like to thank Alfredo Alexander-Katz, Christopher Drew, and Betty-Ann Welsh for useful discussions. This research was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Natick Soldier Research, Development, and Engineering Center administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and NSRDEC. NR 20 TC 0 Z9 0 U1 1 U2 5 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 2159-3930 J9 OPT MATER EXPRESS JI Opt. Mater. Express PD DEC 1 PY 2014 VL 4 IS 12 BP 2656 EP 2662 DI 10.1364/OME.4.002656 PG 7 WC Materials Science, Multidisciplinary; Optics SC Materials Science; Optics GA AW1EU UT WOS:000346034100022 ER PT J AU Walsh, MR Walsh, ME Voie, OA AF Walsh, Michael R. Walsh, Marianne E. Voie, Oyvind A. TI Presence and Persistence of White Phosphorus On Military Training Ranges SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE White phosphorus; Residues; Persistence; Contamination; Training ranges ID DUCKS; WATERFOWL; KESTRELS; SIZE AB The use of obscurants is a common practice by militaries worldwide. One of the most effective of these is white phosphorus (WP). WP is the elemental form of phosphorus that does not occur in nature and is highly toxic. The use of WP rounds on training ranges has led to a number of die-offs of grazing land animals and dabbling waterfowl, the first recorded in 1930. In the 1980s, thousands of waterfowl were dying annually at an impact range in Alaska, leading to the first large-scale investigation of WP as a lethal range contaminant. Tests were conducted at an upland impact range in New York to determine the quantity and persistence of WP in a typical environment. At all sites cited in this paper, WP was persistent for months to years following the detonation of WP munitions. At the Eagle River Flats range in AK, WP was identified from rounds fired in the 1950s, persisting over 45 years in a non-saturated environment. In New York, dispersal of gram quantities of WP occurred at detonation, and high concentrations of WP were found in the detonation craters a year after firing. Caution needs to be exercised when using white phosphorus munitions on ranges. C1 [Walsh, Michael R.; Walsh, Marianne E.] US Army Corps Engineers, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Voie, Oyvind A.] Norwegian Def Res Estab FFI, Norwegian Minist Def, N-2027 Kjeller, Norway. RP Walsh, MR (reprint author), US Army Corps Engineers, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM Michael.Walsh@usace.army.mil NR 36 TC 1 Z9 1 U1 1 U2 5 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 0721-3115 EI 1521-4087 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD DEC PY 2014 VL 39 IS 6 BP 922 EP 931 DI 10.1002/prep.201400107 PG 10 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA AW1PO UT WOS:000346062000020 ER PT J AU Knapik, JJ Steelman, R Hoedebecke, K Rankin, S Klug, K Collier, K Jones, BH AF Knapik, Joseph J. Steelman, Ryan Hoedebecke, Kyle Rankin, Shawn Klug, Kevin Collier, Keith Jones, Bruce H. TI Injury incidence with T-10 and T-11 Parachutes in Military Airborne Operations SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE wind; temperature; night; combat load; aircraft entanglement ID RISK-FACTORS; ALTITUDE; SYSTEM AB Background: The T-10 parachute has been the U.S. Army standard parachute since 1952 and is now being replaced by the T-11, which has a capacity for heavier loads. This investigation compared injury rates between the two parachute systems during mass tactical parachute training exercises at Fort Bragg, NC. Methods: Investigators were on the drop zone for all parachute operations. Data on injured jumpers were collected on the drop zone and supplemented with medical records. Operational data were collected from standard reports and weather data were obtained using a Kestrel Model 4500 pocket weather tracker. Results: There were a total of 131,747 jumps resulting in 1101 injured service members for a crude incidence of 8.4 injuries/1000 jumps. Most injuries (88%) with a known injury mechanism were associated with ground impact. In univariate analysis, risk of injury with the T-10 was 9.1/1000 jumps and that with the T-11 was 5.2/1000 jumps [odds ratio (T-10/T-11) = 1.72, 95% confidence interval (95%CI) = 1.45-2.08, P<0.011. Other factors that independently increased injury risk included night jumps, combat loads, higher wind speeds, higher temperatures, certain aircraft, and entanglements. After controlling for these factors in a multivariate analysis, injury risk was still higher for the T-10 parachute when compared to the T-11 [odds ratio (T-10/T-11) = 1.56, 95%CI = 1.28-1.89, P<0.01). For virtually all strata of the independent risk factors, the T-11 had a lower injury rate. Conclusion: Compared to the T-10, the T-11 parachute had a lower injury incidence under virtually all the operational conditions examined. C1 US Army, Inst Publ Hlth, Aberdeen Proving Ground, MD 21010 USA. Womack Army Med Ctr, Ft Bragg, NC USA. Concurrent Technol Corp, Fayetteville, NC USA. Program Management Off, Ft Belvoir, VA USA. Oak Ridge Inst Sci & Educ, Belcamp, MD USA. RP Knapik, JJ (reprint author), US Army, Inst Publ Hlth, ATTN MCHB IP DI, Aberdeen Proving Ground, MD 21010 USA. EM joseph.j.knapik.ctr@mail.mil FU Office of the Assistant Secretary of the Army (Installations, Energy and Environment) [W74V8H-04-D-0005 Tasks 0517, 0568] FX We would like to thank the numerous personnel from the 82nd Airborne Division and XVIII Airborne Corps who supported this effort. These included LTC Robert Malsby, LTC Michael Sassano, COL Michael Smith, Dr. Ellen Segan, Mr. Tommie Brown, Mr. Earl Jefferson, CPT King Cooper, MSG Todd Winhoven, CW3 Thompson, CW4 Lewis, Mr. Nick Weidler, Mr. Terence Hensey, CW5 Frazier, CW3 Rojas, and SFC Jess Brown. Data collection work was funded through the Office of the Assistant Secretary of the Army (Installations, Energy and Environment) and conducted under contract W74V8H-04-D-0005 Tasks 0517 and 0568. This project was supported in part by an appointment to the Research Participation Program for the U.S. Army Public for Health Command administered by the Oak Ridge Institute for Science and Education through an agreement between the U.S. Department of Energy and the USAPHC. NR 33 TC 3 Z9 3 U1 1 U2 2 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 EI 1943-4448 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD DEC PY 2014 VL 85 IS 12 BP 1159 EP 1169 DI 10.3357/ASEM.4012.2014 PG 11 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA AU8BA UT WOS:000345820500001 PM 25479257 ER PT J AU Martini, AK Rodriguez, CM Cap, AP Martini, WZ Dubick, MA AF Martini, Angela K. Rodriguez, Cassandra M. Cap, Andrew P. Martini, Wenjun Z. Dubick, Michael A. TI Acetaminophen and meloxicam inhibit platelet aggregation and coagulation in blood samples from humans SO BLOOD COAGULATION & FIBRINOLYSIS LA English DT Article DE and human blood; nonsteroidal anti-inflammatory drug (NSAID); platelet aggregation; thrombelastogram ID HEALTHY; TOLERABILITY; PARAMETERS; ASPIRIN; DISEASE; ADULTS; DOGS AB Acetaminophen (Ace) and meloxicam (Mel) are the two types of analgesic and antipyretic medications. This study investigated the dose responses of acetaminophen and meloxicam on platelet aggregation and coagulation function in human blood samples. Blood samples were collected from six healthy humans and processed to make platelet-adjusted (100x10(3)cells/l) blood samples. Acetaminophen (Tylenol, Q-PAP, 100mg/ml) was added at the doses of 0g/ml (control), 214g/ml (the standard dose, 1x), 4x, 8x, 10x, 12x, 16x, and 20x. Similarly, meloxicam (Metacam, 5mg/ml) was added at doses of 0g/ml (control), 2.85g/ml (the standard dose, 1x), 4x, 8x, 10x, 12x, 16x, and 20x. Fifteen minutes after the addition of acetaminophen and/or meloxicam, platelet aggregation was stimulated with collagen (2g/ml) or arachidonic acid (0.5mmol/l) and assessed using a Chrono-Log 700 aggregometer. Coagulation function was assessed by prothrombin time (PT), activated partial thromboplastin time (aPTT), and using Rotem thrombelastogram. A robust inhibition by acetaminophen and/or meloxicam was observed in arachidonic acid-stimulated platelet aggregation starting at 1x dose. Collagen-stimulated platelet aggregation was inhibited by ACE starting at 1x (78 +/- 10% of control), and by meloxicam starting at 4x (72 +/- 5% of control, both P<0.05). The inhibitions by acetaminophen and meloxicam combined were similar to those by acetaminophen or meloxicam. aPTT was prolonged by meloxicam starting at 4x. No changes were observed in PT or any of Rotem measurements by acetaminophen and/or meloxicam. Acetaminophen and meloxicam compromised platelet aggregation and aPTT. Further effort is warranted to characterize the effects of acetaminophen and meloxicam on bleeding in vivo. C1 [Martini, Angela K.] Rice Univ, Houston, TX USA. [Rodriguez, Cassandra M.; Cap, Andrew P.; Martini, Wenjun Z.; Dubick, Michael A.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA. RP Martini, WZ (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA. EM wenjun.z.martini.civ@mail.mil FU U.S. Army Medical Research and Materiel Command FX This study was supported by the U.S. Army Medical Research and Materiel Command. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U. S. Department of the Army or the U. S. Department of Defense. NR 22 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0957-5235 EI 1473-5733 J9 BLOOD COAGUL FIBRIN JI Blood Coagul. Fibrinolysis PD DEC PY 2014 VL 25 IS 8 BP 831 EP 837 DI 10.1097/MBC.0000000000000162 PG 7 WC Hematology SC Hematology GA AT4QZ UT WOS:000344927000009 PM 25004022 ER PT J AU Kasten, SA Zulli, S Jones, JL Dephillipo, T Cerasoli, DM AF Kasten, Shane A. Zulli, Steven Jones, Jonathan L. Dephillipo, Thomas Cerasoli, Douglas M. TI Chiral Separation of G-type Chemical Warfare Nerve Agents via Analytical Supercritical Fluid Chromatography SO CHIRALITY LA English DT Article DE organophosphorus (OP); tabun (GA); sarin (GB); soman (GD); cyclosarin (GF); chiral stationary phase (CSP); Regis WhelkO1 ID SWINE BLOOD-SAMPLES; 4 STEREOISOMERS; LIQUID-CHROMATOGRAPHY; ACUTE TOXICITY; ENANTIOMERS; SOMAN; QUANTIFICATION; ATTACK; MICE AB Chemical warfare nerve agents (CWNAs) are extremely toxic organophosphorus compounds that contain a chiral phosphorus center. Undirected synthesis of G-type CWNAs produces stereoisomers of tabun, sarin, soman, and cyclosarin (GA, GB, GD, and GF, respectively). Analytical-scale methods were developed using a supercritical fluid chromatography (SFC) system in tandem with a mass spectrometer for the separation, quantitation, and isolation of individual stereoisomers of GA, GB, GD, and GF. Screening various chiral stationary phases (CSPs) for the capacity to provide full baseline separation of the CWNAs revealed that a Regis WhelkO1 (SS) column was capable of separating the enantiomers of GA, GB, and GF, with elution of the P(+) enantiomer preceding elution of the corresponding P(-) enantiomer; two WhelkO1 (SS) columns had to be connected in series to achieve complete baseline resolution. The four diastereomers of GD were also resolved using two tandem WhelkO1 (SS) columns, with complete baseline separation of the two P(+) epimers. A single WhelkO1 (RR) column with inverse stereochemistry resulted in baseline separation of the GD P(-) epimers. The analytical methods described can be scaled to allow isolation of individual stereoisomers to assist in screening and development of countermeasures to organophosphorus nerve agents. Chirality 26:817-824, 2014. (c) 2014 The Authors. Chirality published by John Wiley Periodicals, Inc. C1 [Kasten, Shane A.; Cerasoli, Douglas M.] US Army, Med Res Inst Chem Def, Div Res, Physiol & Immunol Branch, Aberdeen Proving Ground, MD 21010 USA. [Zulli, Steven; Jones, Jonathan L.] Waters Corp, New Castle, DE USA. [Dephillipo, Thomas] Waters Corp, Milford, MA USA. RP Kasten, SA (reprint author), US Army, Med Res Inst Chem Def, Div Res, Physiol & Immunol Branch, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM shane.a.kasten.ctr@mail.mil; douglas.m.cerasoli.civ@mail.mil FU Defense Threat Reduction Agency-Joint Science and Technology Office, Medical ST Division; U.S. Department of Energy; USAMRICD FX We would like to thank John Richard Smith for insightful discussions on chiral analysis, for kindly sharing reagents, and for previously establishing initial conditions for chiral separations of CWNAs at the USAMRICD. We also thank Jon Oyler, USAMRICD, for thoughtful discussion and review of this manuscript. Also we thank Dan Rolle and Lakshmi Subbarao from Waters Corporation for technical assistance important for making this study possible. This work was supported by the Defense Threat Reduction Agency-Joint Science and Technology Office, Medical S&T Division. S.A.K. was supported in part by an appointment to the Internship/Research Participation Program for the U.S. Army Medical Research Institute of Chemical Defense, administered by the Oak Ridge Institute for Science and Education through an agreement between the U.S. Department of Energy and the USAMRICD. The views expressed in this article are those of the author(s) and do not reflect the official policy of the Department of Army, Department of Defense, or the U.S. Government. NR 19 TC 2 Z9 2 U1 4 U2 27 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0899-0042 EI 1520-636X J9 CHIRALITY JI Chirality PD DEC PY 2014 VL 26 IS 12 BP 817 EP 824 DI 10.1002/chir.22368 PG 8 WC Chemistry, Medicinal; Chemistry, Analytical; Chemistry, Organic; Pharmacology & Pharmacy SC Pharmacology & Pharmacy; Chemistry GA AU5EO UT WOS:000345630200009 PM 25298066 ER PT J AU Flores, M Longnecker, M Tomberlin, JK AF Flores, Micah Longnecker, Michael Tomberlin, Jeffery K. TI Effects of temperature and tissue type on Chrysomya rufifacies (Diptera: Calliphoridae) (Macquart) development SO FORENSIC SCIENCE INTERNATIONAL LA English DT Article DE Hairy maggot; Blow fly; Forensic entomology; Phenotypic plasticity ID COCHLIOMYIA-MACELLARIA DIPTERA; LUCILIA-SERICATA DIPTERA; PHORMIA-REGINA DIPTERA; DIFFERENT BODY-TISSUES; FORENSIC ENTOMOLOGY; BLOW FLIES; RATES; POPULATION; LARVAE; FLY AB The hairy maggot blow fly, Chrysomya rufifacies (Diptera: Calliphoridae), is a forensically important fly often encountered on human and other vertebrate remains in temperate and tropic regions throughout the world including Australia, Asia, Central America and North America. C. rufifacies was reared under controlled laboratory conditions on three muscle types (i.e., porcine, equine and canine) at three temperatures (i. e., 20.8, 24.8 and 28.3 degrees C). Rate of larval weight gain across time was statistically significant between muscle types (P <= 0.0001) and approaching significance across time between temperatures (P = 0.0511). This research represents the first development study for C. rufifacies from central Texas, USA and the first study to examine the impact of tissue type on its development. Furthermore, these data, when compared to those available in the literature, indicate developmental differences that could be due to genetic differences in populations or possibly methods employed during the studies. Caution should be emphasized when applying development data for this species from one region to forensic investigations in other ecoregions as such differences in development based on tissue fed upon by larvae, population genetics, and methodologies used in the studies could represent error in estimating the time of colonization. (C) 2014 Elsevier Ireland Ltd. All rights reserved. C1 [Flores, Micah; Tomberlin, Jeffery K.] Texas A&M Univ, Dept Entomol, College Stn, TX 77843 USA. [Longnecker, Michael] Texas A&M Univ, Dept Stat, College Stn, TX 77843 USA. [Flores, Micah] Walter Reed Army Inst Res, Bacterial & Rickettsial Dept, Silver Spring, MD USA. RP Flores, M (reprint author), Texas A&M Univ, Dept Entomol, 2475 TAMU, College Stn, TX 77843 USA. EM chrysomicah@gmail.com FU Agrilife Research; Department of Entomology; J.H. Benedict, Sr. Memorial Scholarship FX MF and JKT would like to thank Agrilife Research and the Department of Entomology for providing partial financial support for this study. Additionally we would like to thank the J.H. Benedict, Sr. Memorial Scholarship for support during this research. They would also like to thank Aaron M. Tarone and two anonymous reviewers for comments on earlier drafts of this manuscript. NR 37 TC 9 Z9 10 U1 3 U2 52 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0379-0738 EI 1872-6283 J9 FORENSIC SCI INT JI Forensic Sci.Int. PD DEC PY 2014 VL 245 BP 24 EP 29 DI 10.1016/j.forsciint.2014.09.023 PG 6 WC Medicine, Legal SC Legal Medicine GA AU5DT UT WOS:000345628100015 PM 25447170 ER PT J AU Drake, DL Anderson, TL Smith, LM Lohraff, KM Semlitsch, RD AF Drake, Dana L. Anderson, Thomas L. Smith, Lauren M. Lohraff, Kenton M. Semlitsch, Raymond D. TI PREDATION OF EGGS AND RECENTLY HATCHED LARVAE OF ENDEMIC RINGED SALAMANDERS (AMBYSTOMA ANNULATUM) BY NATIVE AND INTRODUCED AQUATIC PREDATORS SO HERPETOLOGICA LA English DT Article DE Amphibians; Community structure; Food choice; Hatchlings; Management; Palatability; Refuge; Survival ID MOSQUITOFISH GAMBUSIA-AFFINIS; NOTOPHTHALMUS-VIRIDESCENS; EXPERIMENTAL WETLANDS; HABITAT COMPLEXITY; PREY INTERACTIONS; POND COMMUNITIES; AMPHIBIAN LARVAE; FISH PREDATION; TADPOLES; SIZE AB Predation is a key determinant of pond community structure, yet not all predators are equally effective and not all life stages of potential prey are similarly susceptible. Understanding the effects of native and introduced species is essential to informing management strategies, especially for endemic and species of conservation concern. We examined the effects of five common predators (three native: Central Newts [Notophthalmus viridescens louisianensis], aeshnid dragonfly naiads [Aeshnidae], and Southern Leopard Frog tadpoles [Lithobates sphenocephalus]; and two introduced: Fathead Minnows [Pimephales promelas] and Mosquitofish [Gambusia affinis]) on survival of eggs and recently hatched larvae of Ringed Salamanders (Ambystoma annulatum). We also examined the effect of supplemental food or cover availability on survival at each stage. Predators primarily showed a binary response to eggs, consuming all or none of them. Supplemental food did not influence whether eggs or larvae were consumed. Larvae were consumed by all predator species although the effect varied. The presence of cover did not reduce the impacts of the other predators on larval survival. Overall, the two introduced fish species had a greater impact on survival of the early stages of Ringed Salamanders than did the native predators. Further inquiries into the susceptibility of different life stages and survival will improve conservation strategies for rare and endemic species such as Ringed Salamanders. C1 [Drake, Dana L.; Anderson, Thomas L.; Smith, Lauren M.; Semlitsch, Raymond D.] Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA. [Lohraff, Kenton M.] US Army, IMCOM, Ft Leonard Wood, MO 65473 USA. [Lohraff, Kenton M.] US Army, FLW, DPW Nat Resources Branch, Ft Leonard Wood, MO 65473 USA. RP Drake, DL (reprint author), Univ Missouri, Div Biol Sci, 105 Tucker Hall, Columbia, MO 65211 USA. EM drake.dana.l@gmail.com OI Semlitsch, Raymond/0000-0002-7999-5762 FU Department of Defense Strategic Environmental Research Development Program [RC2155] FX We thank J. Robinson and S. Politte for assistance with laboratory setup and data collection. This research was approved by the University of Missouri Animal Care and Use Committee (Protocol no. 7403), collections were made under Missouri Department of Conservation Research Permit (no. 15562), and it was supported by the Department of Defense Strategic Environmental Research Development Program (Award no. RC2155). NR 50 TC 8 Z9 8 U1 4 U2 38 PU HERPETOLOGISTS LEAGUE PI EMPORIA PA EMPORIA STATE UNIV, DIVISION BIOLOGICAL SCIENCES, 1200 COMMERCIAL ST, EMPORIA, KS 66801-5087 USA SN 0018-0831 EI 1938-5099 J9 HERPETOLOGICA JI Herpetologica PD DEC PY 2014 VL 70 IS 4 BP 378 EP 387 PG 10 WC Zoology SC Zoology GA AU8HS UT WOS:000345837900002 ER PT J AU Rakesh, V Stallings, JD Reifman, J AF Rakesh, Vineet Stallings, Jonathan D. Reifman, Jaques TI A virtual rat for simulating environmental and exertional heat stress SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE three-dimensional computational rat model; heat transfer; core temperature circadian rhythm; organ-specific response; whole body cooling ID BODY-TEMPERATURE; STROKE; EXERCISE; HEATSTROKE; BRAIN; GHZ AB Severe cases of environmental or exertional heat stress can lead to varying degrees of organ dysfunction. To understand heat-injury progression and develop efficient management and mitigation strategies, it is critical to determine the thermal response in susceptible organs under different heat-stress conditions. To this end, we used our previously published virtual rat, which is capable of computing the spatiotemporal temperature distribution in the animal, and extended it to simulate various heat-stress scenarios, including 1) different environmental conditions, 2) exertional heat stress, 3) circadian rhythm effect on the thermal response, and 4) whole body cooling. Our predictions were consistent with published in vivo temperature measurements for all cases, validating our simulations. We observed a differential thermal response in the organs, with the liver experiencing the highest temperatures for all environmental and exertional heat-stress cases. For every 3 degrees C rise in the external temperature from 40 to 46 degrees C, core and organ temperatures increased by similar to 0.8 degrees C. Core temperatures increased by 2.6 and 4.1 degrees C for increases in exercise intensity from rest to 75 and 100% of maximal O-2 consumption, respectively. We also found differences as large as 0.8 degrees C in organ temperatures for the same heat stress induced at different times during the day. Even after whole body cooling at a relatively low external temperature (1 degrees C for 20 min), average organ temperatures were still elevated by 2.3 to 2.5 degrees C compared with normothermia. These results can be used to optimize experimental protocol designs, reduce the amount of animal experimentation, and design and test improved heat-stress prevention and management strategies. C1 [Rakesh, Vineet; Reifman, Jaques] US Army Med Res & Mat Command, MCMR TT, Telemed & Adv Technol Res Ctr, Dept Def,Biotechnol High Performance Comp Softwar, Ft Detrick, MD 21702 USA. [Stallings, Jonathan D.] US Army Ctr Environm Hlth Res, Environm Hlth Program, Ft Detrick, MD USA. RP Reifman, J (reprint author), US Army Med Res & Mat Command, MCMR TT, Telemed & Adv Technol Res Ctr, Dept Def,Biotechnol High Performance Comp Softwar, 504 Scott St, Ft Detrick, MD 21702 USA. EM jaques.reifman.civ@mail.mil OI Stallings, Jonathan/0000-0002-6430-5888 FU U.S. Army Network Science Initiative; Military Operational Medicine Research Program, U.S. Army Medical Research and Materiel Command, Fort Detrick, MD FX The research was supported by the U.S. Army Network Science Initiative and the Military Operational Medicine Research Program, U.S. Army Medical Research and Materiel Command, Fort Detrick, MD. NR 27 TC 1 Z9 2 U1 1 U2 6 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 EI 1522-1601 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD DEC 1 PY 2014 VL 117 IS 11 BP 1278 EP 1286 DI 10.1152/japplphysiol.00614.2014 PG 9 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA AW0ZZ UT WOS:000346021300006 PM 25277741 ER PT J AU Stewart, CL Mulligan, J Grudic, GZ Convertino, VA Moulton, SL AF Stewart, Camille L. Mulligan, Jane Grudic, Greg Z. Convertino, Victor A. Moulton, Steven L. TI Detection of low-volume blood loss: Compensatory reserve versus traditional vital signs SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article; Proceedings Paper CT 44th Annual Meeting of the Western-Trauma-Association CY MAR 02-07, 2014 CL Steamboat Springs, CO SP Western Trauma Assoc DE Machine learning; compensatory reserve index; photoplethysmogram; acute blood loss ID BODY NEGATIVE-PRESSURE; PLETH VARIABILITY INDEX; FLUID RESPONSIVENESS; BASE DEFICIT; CENTRAL HYPOVOLEMIA; TRAUMA PATIENTS; EARLY-DIAGNOSIS; SHOCK; HEMORRHAGE; THERAPY AB BACKGROUND: Humans are able to compensate for low-volume blood loss with minimal change in traditional vital signs. We hypothesized that a novel algorithm, which analyzes photoplethysmogram (PPG) wave forms to continuously estimate compensatory reserve would provide greater sensitivity and specificity to detect low-volume blood loss compared with traditional vital signs. The compensatory reserve index (CRI) is a measure of the reserve remaining to compensate for reduced central blood volume, where a CRI of 1 represents supine normovolemia and 0 represents the circulating blood volume at which hemodynamic decompensation occurs; values between 1 and 0 indicate the proportion of reserve remaining. METHODS: Subjects underwent voluntary donation of 1 U (approximately 450 mL) of blood. Demographic and continuous noninvasive vital sign wave form data were collected, including PPG, heart rate, systolic blood pressure, cardiac output, and stroke volume. PPG wave forms were later processed by the algorithm to estimate CRI values. RESULTS: Data were collected from 244 healthy subjects (79 males and 165 females), with a mean (SD) age of 40.1 (14.2) years and mean (SD) body mass index of 25.6 (4.7). After blood donation, CRI significantly decreased in 92% (alpha = 0.05; 95% confidence interval [CI], 88-95%) of the subjects. With the use of a threshold decrease in CRI of 0.05 or greater for the detection of 1 U of blood loss, the receiver operating characteristic area under the curve was 0.90, with a sensitivity of 0.84 and specificity of 0.86. In comparison, systolic blood pressure (52%; 95% CI, 45-59%), heart rate (65%; 95% CI, 58-72%), cardiac output (47%; 95% CI, 40-54%), and stroke volume (74%; 95% CI, 67-80%) changed in fewer subjects, had significantly lower receiver operating characteristic area under the curve values, and significantly lower specificities for detecting the same volume of blood loss. CONCLUSION: Consistent with our hypothesis, CRI detected low-volume blood loss with significantly greater specificity than other traditional physiologic measures. These findings warrant further evaluation of the CRI algorithm in actual trauma settings. (Copyright 0 2014 by Lippincott Williams & Wilkins) C1 [Stewart, Camille L.; Moulton, Steven L.] Univ Colorado, Dept Surg, Sch Med, Boulder, CO 80309 USA. [Mulligan, Jane; Grudic, Greg Z.; Moulton, Steven L.] Flashback Technol Inc, Boulder, CO USA. [Moulton, Steven L.] Childrens Hosp Colorado, Div Pediat Surg, Aurora, CO 80045 USA. [Convertino, Victor A.] US Army Inst Surg Res, San Antonio, TX USA. RP Moulton, SL (reprint author), Childrens Hosp Colorado, B-323,13123 E 16th Ave, Aurora, CO 80045 USA. EM Steven.moulton@childrenscolorado.org NR 40 TC 11 Z9 11 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD DEC PY 2014 VL 77 IS 6 BP 892 EP 897 DI 10.1097/TA.0000000000000423 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA AU8EE UT WOS:000345828500023 PM 25423536 ER PT J AU Xia, FN Wang, H Xiao, D Dubey, M Ramasubramaniam, A AF Xia, Fengnian Wang, Han Xiao, Di Dubey, Madan Ramasubramaniam, Ashwin TI Two-dimensional material nanophotonics SO NATURE PHOTONICS LA English DT Review ID ULTRAFAST GRAPHENE PHOTODETECTOR; TRANSITION-METAL DICHALCOGENIDES; LIGHT-MATTER INTERACTIONS; FIELD-EFFECT TRANSISTORS; LAYER BLACK PHOSPHORUS; ATOMICALLY THIN MOS2; PHOTOCURRENT GENERATION; VALLEY POLARIZATION; ELECTRICAL CONTROL; HIGH-RESPONSIVITY AB Two-dimensional materials exhibit diverse electronic properties, ranging from insulating hexagonal boron nitride and semiconducting transition metal dichalcogenides such as molybdenum disulphide, to semimetallic graphene. In this Review, we first discuss the optical properties and applications of various two-dimensional materials, and then cover two different approaches for enhancing their interactions with light: through their integration with external photonic structures, and through intrinsic polaritonic resonances. Finally, we present a narrow-bandgap layered material - black phosphorus - that serendipitously bridges the energy gap between the zero-bandgap graphene and the relatively large-bandgap transition metal dichalcogenides. The plethora of two-dimensional materials and their heterostructures, together with the array of available approaches for enhancing the light-matter interaction, offers the promise of scientific discoveries and nanophotonics technologies across a wide range of the electromagnetic spectrum. C1 [Xia, Fengnian] Yale Univ, Dept Elect Engn, New Haven, CT 06511 USA. [Wang, Han] Univ So Calif, Ming Hsieh Dept Elect Engn, Los Angeles, CA 90089 USA. [Xiao, Di] Carnegie Mellon Univ, Dept Phys, Pittsburgh, PA 15213 USA. [Dubey, Madan] Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Ramasubramaniam, Ashwin] Univ Massachusetts, Dept Mech & Ind Engn, Amherst, MA 01003 USA. RP Xia, FN (reprint author), Yale Univ, Dept Elect Engn, 15 Prospect St, New Haven, CT 06511 USA. EM fengnian.xia@yale.edu RI Xiao, Di/B-1830-2008; Ramasubramaniam, Ashwin/A-4608-2009; Xia, Fengnian/O-2637-2015 OI Xiao, Di/0000-0003-0165-6848; Ramasubramaniam, Ashwin/0000-0001-6595-7442; Xia, Fengnian/0000-0001-5176-368X FU Office of Naval Research [N00014-14-1-0565]; Air Force Office of Scientific Research [FA9550-14-1-0277]; National Science Foundation (CRISP NSF MRSEC) [DMR-1119826]; Army Research Laboratory [W911NF-14-2-0113]; Department of Energy [SC0012509]; National Science Foundation [EFRI-1433496] FX We thank X. Xu at the University of Washington, Seattle and M. Dresselhaus at Massachusetts Institute of Technology for insightful comments. We would also like to thank T. Low at the University of Minnesota for his input at the early stage of this project and L. Wang at the University of Southern California for designing Fig. 6c,d. F.X. acknowledges support from the Office of Naval Research (N00014-14-1-0565), the Air Force Office of Scientific Research (FA9550-14-1-0277) and the National Science Foundation (CRISP NSF MRSEC DMR-1119826). H.W. acknowledges support from the Army Research Laboratory (W911NF-14-2-0113). D.X. acknowledges support from the Department of Energy (SC0012509), the Air Force Office of Scientific Research (FA9550-14-1-0277), and the National Science Foundation (EFRI-1433496). NR 97 TC 295 Z9 297 U1 140 U2 788 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1749-4885 EI 1749-4893 J9 NAT PHOTONICS JI Nat. Photonics PD DEC PY 2014 VL 8 IS 12 BP 899 EP 907 DI 10.1038/NPHOTON.2010.271 PG 9 WC Optics; Physics, Applied SC Optics; Physics GA AU8AG UT WOS:000345818600008 ER PT J AU Phillips, BN Chun, D Barnes, SD AF Phillips, Brandon N. Chun, Dal Barnes, Scott D. TI Untitled Reply SO RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES LA English DT Letter C1 [Phillips, Brandon N.; Barnes, Scott D.] Womack Army Med Ctr, Ophthalmol Serv, Ft Bragg, NC 28307 USA. [Chun, Dal] Retina Grp Washington, Washington, DC USA. RP Phillips, BN (reprint author), Womack Army Med Ctr, Ophthalmol Serv, Ft Bragg, NC 28307 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0275-004X EI 1539-2864 J9 RETINA-J RET VIT DIS JI Retin.-J. Retin. Vitr. Dis. PD DEC PY 2014 VL 34 IS 12 BP E41 EP E41 PG 1 WC Ophthalmology SC Ophthalmology GA AU9KK UT WOS:000345911300003 PM 25407236 ER PT J AU Kim, S Bedigrew, K Guda, T Maloney, WJ Park, S Wenke, JC Yang, YP AF Kim, Sungwoo Bedigrew, Katherine Guda, Teja Maloney, William J. Park, Sangwon Wenke, Joseph C. Yang, Yunzhi Peter TI Novel osteoinductive photo-cross-linkable chitosan-lactide-fibrinogen hydrogels enhance bone regeneration in critical size segmental bone defects SO ACTA BIOMATERIALIA LA English DT Article DE Chitosan; Lactide; Fibrinogen; Photo-cross-linkable hydrogel; BMP-2 ID HEPARIN-BINDING DOMAIN; MORPHOGENETIC PROTEIN-2; GROWTH-FACTORS; CONTROLLED-RELEASE; IN-VITRO; DELIVERY; BMP-2; MATRIX; REPAIR; DEGRADATION AB The purpose of this study was to develop and characterize a novel photo-cross-linkable chitosan-lactide-fibrinogen (CLF) hydrogel and evaluate the efficacy of bone morphogenetic protein-2 (BMP-2) containing a CLF hydrogel for osteogenesis in vitro and in vivo. We synthesized the CLF hydrogels and characterized their chemical structure, degradation rate, compressive modulus and in vitro BMP-2 release kinetics. We evaluated bioactivities of the BMP-2 containing CLF hydrogels (0, 50, 100 and 500 ng ml(-1)) in vitro using W-20-17 preosteoblast mouse bone marrow stromal cells and C2C12 mouse myoblast cells. The effect of BMP-2 containing CLF gels (0, 0.5, 1, 2 and 5 mu g) on bone formation was evaluated using rat critical size segmental bone defects for 4 weeks. Fourier transform infrared spectroscopy spectra and scanning electron microscopy images showed chemical and structural changes by the addition of fibrinogen into the chitosan-lactide copolymer. The incorporation of fibrinogen molecules significantly increased the compressive modulus of the hydrogels. The in vitro BMP-2 release study showed initial burst releases from the CLF hydrogels followed by sustained releases, regardless of the concentration of the BMP-2 over 4 weeks. Cells in all groups were viable in the presence of the hydrogels regardless of BMP-2 doses, indicating non-cytotoxicity of hydrogels. Alkaline phosphate activity and mineralization of cells exhibited dose dependence on BMP-2 containing CLF hydrogels. Radiography, microcomputed tomography and histology confirmed that the BMP-2 containing CLF hydrogels prompted neo-osteogenesis and accelerated healing of the defects in a dose-dependent manner. Thus the CLF hydrogel is a promising delivery system of growth factors for bone regeneration. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Kim, Sungwoo; Maloney, William J.; Yang, Yunzhi Peter] Stanford Univ, Dept Orthoped Surg, Stanford, CA 94305 USA. [Bedigrew, Katherine; Wenke, Joseph C.] US Army, Extrem Trauma & Regenerat Med Task Area, Inst Surg Res, San Antonio, TX USA. [Guda, Teja] US Army, Dept Craniomaxillofacial Regenerat Med Dent & Tra, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Park, Sangwon] Chonnam Natl Univ, Sch Dent, Dept Prosthodont, Dent Sci Res Inst, Kwangju, South Korea. [Park, Sangwon] Chonnam Natl Univ, Sch Dent, Project BK21, Kwangju, South Korea. [Yang, Yunzhi Peter] Stanford Univ, Dept Mat Sci & Engn, Stanford, CA 94305 USA. RP Yang, YP (reprint author), Stanford Univ, Dept Orthoped Surg, Stanford, CA 94305 USA. EM ypyang@stanford.edu FU DOD [W81XWH-10-1-0966]; Airlift Research Foundation; Wallace H. Coulter Foundation; NIH from NIAMS [R01AR057837]; NIH from NIDCR [R01DE021468] FX We acknowledge the grant supports from DOD W81XWH-10-1-0966, Airlift Research Foundation, Wallace H. Coulter Foundation, NIH R01AR057837 from NIAMS and NIH R01DE021468 from NIDCR. NR 49 TC 9 Z9 10 U1 7 U2 41 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1742-7061 EI 1878-7568 J9 ACTA BIOMATER JI Acta Biomater. PD DEC PY 2014 VL 10 IS 12 BP 5021 EP 5033 DI 10.1016/j.actbio.2014.08.028 PG 13 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA AU2SQ UT WOS:000345468300011 PM 25174669 ER PT J AU Dickens, JF Owens, BD Cameron, KL Kilcoyne, K Allred, CD Svoboda, SJ Sullivan, R Tokish, JM Peck, KY Rue, JP AF Dickens, Jonathan F. Owens, Brett D. Cameron, Kenneth L. Kilcoyne, Kelly Allred, C. Dain Svoboda, Steven J. Sullivan, Robert Tokish, John M. Peck, Karen Y. Rue, John-Paul TI Return to Play and Recurrent Instability After In-Season Anterior Shoulder Instability A Prospective Multicenter Study SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE glenohumeral; anterior instability; in season; return ID ARTHROSCOPIC BANKART REPAIR; FOLLOW-UP; NONOPERATIVE TREATMENT; INDEX WOSI; DISLOCATION; MANAGEMENT; STABILIZATION; 1ST-TIME; LESIONS; YOUNG AB Background: There is no consensus on the optimal treatment of in-season athletes with anterior shoulder instability, and limited data are available to guide return to play. Purpose: To examine the likelihood of return to sport and the recurrence of instability after an in-season anterior shoulder instability event based on the type of instability (subluxation vs dislocation). Additionally, injury factors and patient-reported outcome scores administered at the time of injury were evaluated to assess the predictability of eventual successful return to sport and time to return to sport during the competitive season. Study Design: Cohort study (prognosis); Level of evidence, 2. Methods: Over 2 academic years, 45 contact intercollegiate athletes were prospectively enrolled in a multicenter observational study to assess return to play after in-season anterior glenohumeral instability. Baseline data collection included shoulder injury characteristics and shoulder-specific patient-reported outcome scores at the time of injury. All athletes underwent an accelerated rehabilitation program without shoulder immobilization and were followed during their competitive season to assess the success of return to play and recurrent instability. Results: Thirty-three of 45 (73%) athletes returned to sport for either all or part of the season after a median 5 days lost from competition (interquartile range, 13). Twelve athletes (27%) successfully completed the season without recurrence. Twenty-one athletes (64%) returned to in-season play and had subsequent recurrent instability including 11 recurrent dislocations and 10 recurrent subluxations. Of the 33 athletes returning to in-season sport after an instability event, 67% (22/33) completed the season. Athletes with a subluxation were 5.3 times more likely (odds ratio [OR], 5.32; 95% CI, 1.00-28.07; P = .049) to return to sport during the same season when compared with those with dislocations. Logistic regression analysis suggests that the Western Ontario Shoulder Instability Index (OR, 1.05; 95% CI, 1.00-1.09; P = .037) and Simple Shoulder Test (OR, 1.03; 95% CI, 1.00-1.05; P = .044) administered after the initial instability event are predictive of the ability to return to play. Time loss from sport after a shoulder instability event was most strongly and inversely correlated with the Simple Shoulder Test (P = .007) at the time of initial injury. Conclusion: In the largest prospective study evaluating shoulder instability in in-season contact athletes, 27% of athletes returned to play and completed the season without subsequent instability. While the majority of athletes who return to sport complete the season, recurrent instability events are common regardless of whether the initial injury was a subluxation or dislocation. C1 US Naval Acad, Annapolis, MD 21402 USA. US Mil Acad, West Point, NY 10996 USA. US Air Force Acad, Colorado Springs, CO 80840 USA. RP Dickens, JF (reprint author), US Mil Acad, Keller Army Hosp, 3328 East Continental Rd, West Point, NY 10996 USA. EM jon.f.dickens@gmail.com OI Cameron, Kenneth/0000-0002-6276-4482 NR 46 TC 15 Z9 15 U1 0 U2 12 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 EI 1552-3365 J9 AM J SPORT MED JI Am. J. Sports Med. PD DEC PY 2014 VL 42 IS 12 BP 2842 EP 2850 DI 10.1177/0363546514553181 PG 9 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA AU4SA UT WOS:000345600600007 PM 25378207 ER PT J AU Brenner, MW Boddu, VM Kumar, A AF Brenner, Matthew W. Boddu, Veera M. Kumar, Ashok TI Control of morphology for energy dissipation in carbon nanotube forests SO APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING LA English DT Article ID SOURCE GASES; GROWTH; COMPOSITES; ARRAYS; WIRES; TIPS AB This study focuses on the effect of carbon precursor on the carbon nanotube (CNT) morphology and energy dissipation. Benzene, toluene, and m-xylene were used as carbon precursors for the synthesis of CNT forests following a chemical vapor deposition process. The results indicate that substituents on the benzene ring increase entanglement in the CNT forests. The absorbed energy was slightly greater for CNT forests synthesized using m-xylene than for toluene, but was much smaller for benzene. When compressed to a strain of 0.67, the toluene CNTs absorbed more energy than the m-xylene CNTs. The restitution was much higher for the forests synthesized with m-xylene than toluene while it further decreased for the forests made with benzene. A strong correlation is also observed between the average diameter of the CNTs and the number of methyl substituents on the benzene ring. The control of the entanglement of the CNT forests can potentially be used to design high energy absorbing composites for blast energy dissipation. C1 [Brenner, Matthew W.; Boddu, Veera M.; Kumar, Ashok] US Army Engn Res & Dev Ctr, Environm Proc Branch, Construct Engn Res Lab ERDC CERL, Champaign, IL 61826 USA. RP Boddu, VM (reprint author), US Army Engn Res & Dev Ctr, Environm Proc Branch, Construct Engn Res Lab ERDC CERL, Champaign, IL 61826 USA. EM Veera.Boddu@usace.army.mil FU U.S. Department of Energy; ERDC-CERL FX This research was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Engineer Research and Development Center, Construction Engineering Research Laboratory (ERDC-CERL) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and ERDC-CERL. NR 33 TC 2 Z9 2 U1 1 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0947-8396 EI 1432-0630 J9 APPL PHYS A-MATER JI Appl. Phys. A-Mater. Sci. Process. PD DEC PY 2014 VL 117 IS 4 BP 1849 EP 1857 DI 10.1007/s00339-014-8812-6 PG 9 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA AU0DI UT WOS:000345293200026 ER PT J AU Shields, BA Brown, JN Aden, JK Salgueiro, M Mann-Salinas, EA Chung, KK AF Shields, Beth A. Brown, Jennifer N. Aden, James K. Salgueiro, Marybeth Mann-Salinas, Elizabeth A. Chung, Kevin K. TI A pilot review of gradual versus goal re-initiation of enteral nutrition after burn surgery in the hemodynamically stable patient SO BURNS LA English DT Article DE Enteral; Burn; Nutrition; Surgery; Calorie ID RESTING ENERGY-EXPENDITURE; CRITICALLY-ILL PATIENTS; PROVISION; PROTOCOL; IMMEDIATE; EFFICACY; TRIAL; ROUTE AB Severe weight loss resulting from inadequate nutritional intake along with the hypermetabolism after thermal injury can result in impaired immune function and delayed wound healing. This observational study was conducted on adults admitted between October 2007 and April 2012 with at least 20% total body surface area burn requiring excision who previously tolerated gastric enteral nutrition at calorie goal and who returned from surgery hemodynamically stable (no new pressor requirement) and compared the effect of goal rate re-initiation versus slow re-initiation after the first excision and grafting. Demographic, intake, and tolerance data were collected during the 36 h following surgery and were analyzed with descriptive and comparative statistics. Data were collected on 14 subjects who met the inclusion criteria. Subjects in the goal rate re-initiation group (n = 7) met a significantly greater percentage of caloric goals (99 +/- 12% versus 58 +/- 21%, p = 0.003) during the 36 h following surgery than subjects in the slow re-initiation group (n = 7). There were no incidences of emesis, aspiration, or ischemic bowel in either group. The goal rate reinitiation group had a 29% incidence of either stool output > 1 L (n = 1) or gastric residual volumes > 500 mL (n = 1), whereas these were not present in the slow re-initiation group (p = 0.462). In conclusion, in this small pilot study, we found that enteral nutrition could be re-initiated after the first excision and grafting in those patients who previously tolerated gastric enteral nutrition meeting caloric goals who return from surgery hemodynamically stable without a significant difference in intolerance and with a significantly higher percentage of calorie goals achieved, but larger studies are required. Published by Elsevier Ltd and ISBI. C1 [Shields, Beth A.; Brown, Jennifer N.; Salgueiro, Marybeth] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. [Aden, James K.; Mann-Salinas, Elizabeth A.; Chung, Kevin K.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Shields, BA (reprint author), US Army Inst Surg Res, Burn Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM beth.shields@us.army.mil FU U.S. Army Institute of Surgical Research FX The Clinical Trials in Burns and Trauma Task Area and the U.S. Army Institute of Surgical Research. NR 21 TC 0 Z9 0 U1 1 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 EI 1879-1409 J9 BURNS JI Burns PD DEC PY 2014 VL 40 IS 8 BP 1587 EP 1592 DI 10.1016/j.burns.2014.02.015 PG 6 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA AU1ER UT WOS:000345364400027 PM 24997527 ER PT J AU Mitchell, TA Hardin, MO Murray, CK Ritchie, JD Cancio, LC Renz, EM White, CE AF Mitchell, Thomas A. Hardin, Mark O. Murray, Clinton K. Ritchie, John D. Cancio, Leopoldo C. Renz, Evan M. White, Christopher E. TI Mucormycosis attributed mortality: A seven-year review of surgical and medical management SO BURNS LA English DT Article DE Mucormycosis; Fungal wound infection; Fungal wound colonization; Trauma; Combat; Amputation; War ID BURN WOUND-INFECTION; FUNGAL-INFECTION; COLONIZATION AB Introduction: Historically, mucormycosis infections have been associated with high mortality. The purpose of this study was to determine the incidence, associated mortality, and management strategies of mucormycosis in a major burn center. Methods: A retrospective review was performed via obtaining all patients with mucormycosis admitted from January 2003 to November 2009 at our adult burn center was performed obtaining demographic data relevant to fungal burn wound infection or colonization. Results: The incidence of mucormycosis at our facility was 4.9 per 1000 admissions; specifically, 11 military casualties and one civilian were diagnosed with mucormycosis. The median percentage Total Body Surface Area (TBSA) burned, 11 patients, or open wound, one patient, was 60 (IQR, 54.1-80.0), and the incidence of documented inhalation injury was 66.7% (8 of 12). Ten patients had surgical amputations. A median of eight days (IQR, 3.5-74.5) elapsed from diagnosis of mucormycosis until death in the 11 patients who expired. The overall mortality was 92%; however, autopsy attributed mucormycosis mortality was 54.5% (6 of 11) with all six patients having invasive mucormycosis. Conclusion: Aggressive surgical intervention should be undertaken for invasive mucormycosis; additionally, implementation of standardized protocols for patients with large soft tissue injuries may mitigate mucormycosis superimposition. Published by Elsevier Ltd and ISBI C1 [Mitchell, Thomas A.; Hardin, Mark O.; Murray, Clinton K.; Ritchie, John D.; Cancio, Leopoldo C.; Renz, Evan M.; White, Christopher E.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP White, CE (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM christopher.eric.white@us.army.mil NR 17 TC 2 Z9 3 U1 1 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 EI 1879-1409 J9 BURNS JI Burns PD DEC PY 2014 VL 40 IS 8 BP 1689 EP 1695 DI 10.1016/j.burns.2014.03.013 PG 7 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA AU1ER UT WOS:000345364400039 PM 24881507 ER PT J AU Kamata, T Natesan, M Warfield, K Aman, MJ Ulrich, RG AF Kamata, Teddy Natesan, Mohan Warfield, Kelly Aman, M. Javad Ulrich, Robert G. TI Determination of Specific Antibody Responses to the Six Species of Ebola and Marburg Viruses by Multiplexed Protein Microarrays SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID LINKED-IMMUNOSORBENT-ASSAY; HEMORRHAGIC-FEVER VIRUSES; NECROSIS-FACTOR-ALPHA; NUCLEOCAPSID PROTEINS; VIRION GLYCOPROTEINS; IFN-ALPHA; NUCLEOPROTEIN; INFECTION; EPITOPES; TRANSCRIPTION AB Infectious hemorrhagic fevers caused by the Marburg and Ebola filoviruses result in human mortality rates of up to 90%, and there are no effective vaccines or therapeutics available for clinical use. The highly infectious and lethal nature of these viruses highlights the need for reliable and sensitive diagnostic methods. We assembled a protein microarray displaying nucleoprotein (NP), virion protein 40 (VP40), and glycoprotein (GP) antigens from isolates representing the six species of filoviruses for use as a surveillance and diagnostic platform. Using the microarrays, we examined serum antibody responses of rhesus macaques vaccinated with trivalent (GP, NP, and VP40) virus-like particles (VLP) prior to infection with the Marburg virus (MARV) (i.e., Marburg marburgvirus) or the Zaire virus (ZEBOV) (i.e., Zaire ebolavirus). The microarray-based assay detected a significant increase in antigen-specific IgG resulting from immunization, while a greater level of antibody responses resulted from challenge of the vaccinated animals with ZEBOV or MARV. Further, while antibody cross-reactivities were observed among NPs and VP40s of Ebola viruses, antibody recognition of GPs was very specific. The performance of mucin-like domain fragments of GP (GP mucin) expressed in Escherichia coli was compared to that of GP ectodomains produced in eukaryotic cells. Based on results with ZEBOV and MARV proteins, antibody recognition of GP mucins that were deficient in posttranslational modifications was comparable to that of the eukaryotic cell-expressed GP ectodomains in assay performance. We conclude that the described protein microarray may translate into a sensitive assay for diagnosis and serological surveillance of infections caused by multiple species of filoviruses. C1 [Kamata, Teddy; Natesan, Mohan; Ulrich, Robert G.] US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Warfield, Kelly; Aman, M. Javad] Integrated BioTherapeut Inc, Gaithersburg, MD USA. RP Ulrich, RG (reprint author), US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA. EM rulrich@bhsai.org FU National Institute of Allergy and Infectious Diseases [R01AI096215]; Defense Threat Reduction Agency [CB3948] FX This research was supported by the National Institute of Allergy and Infectious Diseases (R01AI096215) and the Defense Threat Reduction Agency (contract CB3948). NR 51 TC 6 Z9 8 U1 1 U2 35 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 EI 1556-679X J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD DEC PY 2014 VL 21 IS 12 BP 1605 EP 1612 DI 10.1128/CVI.00484-14 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AU3RX UT WOS:000345532300001 PM 25230936 ER PT J AU Dachir, S Cohen, M Sahar, R Graham, J Eisenkraft, A Horwitz, V Kadar, T AF Dachir, Shlomit Cohen, Maayan Sahar, Rita Graham, John Eisenkraft, Arik Horwitz, Vered Kadar, Tamar TI Beneficial effects of activated macrophages on sulfur mustard-induced cutaneous burns, an in vivo experience SO CUTANEOUS AND OCULAR TOXICOLOGY LA English DT Article DE Hairless guinea pigs; macrophages; MMP; skin; TEWL ID EAR VESICANT MODEL; WOUND REPAIR; NONINVASIVE METHODS; IRANIAN VETERANS; HUMAN ULCERS; MOUSE MODEL; BLOOD UNIT; SKIN; INJURY; COMPLICATIONS AB Objective: Macrophages are known to have key functions in almost every stage of wound healing and there is evidence for their beneficial effects in treating decubital ulcers and deep sternal wound infections in human. This study aimed to investigate the efficacy of a treatment with activated macrophages on ameliorating acute and long-term sulfur mustard (SM) induced skin injuries in the hairless guinea pig (HGP) model. Methods: HGP were exposed to SM vapor and treated with either a single or multiple intradermal injections of human activated macrophages in suspension (hAMS) into the wound bed. Clinical and histological evaluations were conducted up to 4 weeks post-exposure. Results: A single treatment with hAMS early after exposure (15 min and 6 h) resulted in a reduction in the number of damaged cells and vesications in the epidermis at 24 h. A substantial increase in cellular infiltration, mostly polymorphonuclears, was taking place in the hAMS-treated animals starting as early as 1 h after exposure. This flow of inflammatory cells continued, in the treated group, for at least 4 weeks, long after the injected macrophages were not detected. Repeated injections of hAMS (15 min, 48 h and 7 d post-exposure) decreased significantly the area of the wounds and improved the integrity of the barrier function as expressed by measuring trans-epidermal water loss up to 10 d. Conclusions: Our results indicate that the role of macrophages in wound healing is complex; their efficacy may depend on the timing of administration. Further investigation is required to determine whether they are required during the early phase of wound development and/or during the late phase of scar formation and remodeling. C1 [Dachir, Shlomit; Cohen, Maayan; Sahar, Rita; Horwitz, Vered; Kadar, Tamar] Israel Inst Biol Res, Dept Pharmacol, IL-74100 Ness Zion, Israel. [Graham, John] US Army Med Res Inst Chem Def, Aberdeen Proving Ground, MD USA. [Eisenkraft, Arik] Minist Def, NBC Protect Div, Tel Aviv, Israel. [Eisenkraft, Arik] Med Corps Headquarters, IDF, Tel Aviv, Israel. RP Dachir, S (reprint author), Israel Inst Biol Res, Dept Pharmacol, POB 19, IL-74100 Ness Zion, Israel. EM shlomitd@iibr.gov.il FU Defense Threat Reduction Agency - Joint Science and Technology Office, Medical ST Division [W81XWH-08-2-128] FX This work was supported by the Defense Threat Reduction Agency - Joint Science and Technology Office, Medical S&T Division under award #: W81XWH-08-2-128. The authors report no conflicts of interest. NR 55 TC 1 Z9 2 U1 1 U2 6 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1556-9527 EI 1556-9535 J9 CUTAN OCUL TOXICOL JI Cutan. Ocul. Toxicol. PD DEC PY 2014 VL 33 IS 4 BP 317 EP 326 DI 10.3109/15569527.2013.877023 PG 10 WC Ophthalmology; Toxicology SC Ophthalmology; Toxicology GA AU3FR UT WOS:000345498400010 PM 24641113 ER PT J AU Park, S Leonard, L Handler, TE Barstow, K Cebe, KM Chaudhuri, J Hamelin, S Hoskins, J Tayob, N Feng, ZD Yamada, H Xu, CB Harrison, SA AF Park, Stephen Leonard, Lucas Handler, Tristan E. Barstow, Karol Cebe, Katherine M. Chaudhuri, Jayanata Hamelin, Stefan Hoskins, Jason Tayob, Nabhah Feng, Ziding Yamada, Hiroyuki Xu, Chuanbo Harrison, Stephen A. TI Development of a Non-Invasive Test for NAFLD That Distinguishes Isolated Steatosis from NASH and NASH with Mild Fibrosis from NASH with Advanced Fibrosis SO HEPATOLOGY LA English DT Meeting Abstract C1 [Park, Stephen; Leonard, Lucas; Handler, Tristan E.; Barstow, Karol; Cebe, Katherine M.; Chaudhuri, Jayanata; Hamelin, Stefan; Hoskins, Jason; Harrison, Stephen A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Tayob, Nabhah; Feng, Ziding] Univ Texas Houston, MD Anderson Canc Ctr, Houston, TX 77030 USA. [Yamada, Hiroyuki; Xu, Chuanbo] Wako Life Sci Inc, Mountain View, CA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0270-9139 EI 1527-3350 J9 HEPATOLOGY JI Hepatology PD DEC PY 2014 VL 60 IS 6 MA LB-17 BP 1278A EP 1278A PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AU3MI UT WOS:000345517000018 ER PT J AU Harrison, SA Castiblanco, JE Park, S Handler, TE Barstow, K He, WJ Harper, N Ahuja, SK AF Harrison, Stephen A. Castiblanco, John E. Park, Stephen Handler, Tristan E. Barstow, Karol He, Weijing Harper, Nathan Ahuja, Sunil K. TI Whole Genome RNA Sequencing (RNA-seq) Identifies CHI3L1 Gene Expression as a Stronger Discriminator of Isolated Steatosis vs. NASH Compared with Established Biomarker Scoring Systems SO HEPATOLOGY LA English DT Meeting Abstract C1 [Harrison, Stephen A.; Park, Stephen; Handler, Tristan E.; Barstow, Karol] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Castiblanco, John E.; He, Weijing; Harper, Nathan] South Texas Vet Hlth Care Syst, Vet Adm Ctr Personalized Med, San Antonio, TX USA. [Ahuja, Sunil K.] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0270-9139 EI 1527-3350 J9 HEPATOLOGY JI Hepatology PD DEC PY 2014 VL 60 IS 6 MA LB-41 BP 1290A EP 1290A PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AU3MI UT WOS:000345517000041 ER PT J AU Sherburn, JA Hammons, MI Roth, MJ AF Sherburn, Jesse A. Hammons, Michael I. Roth, Michael J. TI Modeling finite thickness slab perforation using a coupled Eulerian-Lagrangian approach SO INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES LA English DT Article DE Penetration; Coupled Eulerian-Lagrangian method; Concrete; Constitutive law; Stochastic ID PENETRATION; MECHANICS; TARGETS; PROJECTILES AB A coupled Eulerian-Lagrangian (CEL) method can be used to model many types of dynamic events. Projectile penetration through solids is particularly well-suited to a CEL method. In this study the CEL method in the commercially-available code Abaqus was used to model a near rigid projectile perforating finite thickness concrete slabs. A near rigid projectile can be modeled as a Lagrangian material with distinct material interfaces, while the solid target can be modeled as an Eulerian material capable of large deformations. An improved concrete constitutive model is also described that was implemented into Abaqus as a user material model. A simplified stochastic model was also implemented to capture some of the heterogeneous nature of concrete. The CEL simulations are compared to experimental data to demonstrate the utility of this method for this type of perforation event. Published by Elsevier Ltd. C1 [Sherburn, Jesse A.; Hammons, Michael I.; Roth, Michael J.] US Army, Engn Res & Dev Ctr, Vicksburg, MS USA. RP Sherburn, JA (reprint author), 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM jesse.a.sherburn@usace.army.mil NR 29 TC 2 Z9 2 U1 2 U2 12 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0020-7683 EI 1879-2146 J9 INT J SOLIDS STRUCT JI Int. J. Solids Struct. PD DEC PY 2014 VL 51 IS 25-26 BP 4406 EP 4413 DI 10.1016/j.ijsolstr.2014.09.007 PG 8 WC Mechanics SC Mechanics GA AU2TM UT WOS:000345470400018 ER PT J AU Hempen, GL Keevin, TM Rodgers, MT Schneider, BM AF Hempen, G. L. Keevin, T. M. Rodgers, M. T. Schneider, B. M. TI Mechanical rock grinding in the Mississippi River: anthropogenic noise production and implications for the federally endangered pallid sturgeon, Scaphirhynchus albus (Forbes & Richardson, 1905) SO JOURNAL OF APPLIED ICHTHYOLOGY LA English DT Article; Proceedings Paper CT 7th International Symposium on Sturgeons - Sturgeons, Science and Society at the Cross-Roads - Meeting the Challenges of the 21st Century CY JUL 21-25, 2013 CL Nanaimo, CANADA SP Vancouver Isl Univ, WSCS ID INNER-EAR; SOUND; FISH; ABUNDANCE; COD AB The use of mechanical rock grinding to remove rock pinnacles and outcroppings, considered to be navigation hazards in the Mississippi River, was evaluated as a less damaging alternative when compared to the more conventional use of drilling and blasting. The project area contains the federally endangered pallid sturgeon (Scaphirhynchus albus) and there was concern that intense sound pressure levels (SPLs) could impact the species. SPLs were measured during production rock grinding (January 2012, just north of Thebes, Illinois) and compared to those values with SPLs known to cause fish mortality, hearing damage, temporary hearing threshold shifts (TTS), and stress. The source SPLs' maxima for each time block analyzed ranged from 160-172dB (re 1Pa @ 1m) at frequencies ranging from 100-1250Hz (1/3-octave band). The highest source SPL maximum recorded for the sound recording session was 172dB (re 1Pa @ 1m) at 1250Hz. These SPL levels at 1m from the grinder were well below levels responsible for mortality or noise induced hearing damage. The impact zone for stress (increases in cortisol) was calculated to be within a 9m radius of the grinder, while the impact zone for TTS was calculated to be within 31m of the grinder. Considering the small impact zones and continuous noise production during grinding, there is a strong possibility that sturgeon would either avoid or move out of the impact zone. C1 [Hempen, G. L.; Keevin, T. M.; Rodgers, M. T.; Schneider, B. M.] US Army Corps Engineers, St Louis, MO 63103 USA. RP Hempen, GL (reprint author), US Army Corps Engineers, 1222 Spruce St, St Louis, MO 63103 USA. EM hempen69@sbcglobal.net NR 26 TC 0 Z9 0 U1 0 U2 14 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0175-8659 EI 1439-0426 J9 J APPL ICHTHYOL JI J. Appl. Ichthyol. PD DEC PY 2014 VL 30 IS 6 SI SI BP 1492 EP 1496 DI 10.1111/jai.12582 PG 5 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA AU4NO UT WOS:000345588500052 ER PT J AU Cole, SD Madren-Whalley, JS Li, AP Dorsey, R Salem, H AF Cole, Stephanie D. Madren-Whalley, Janna S. Li, Albert P. Dorsey, Russell Salem, Harry TI High Content Analysis of an In Vitro Model for Metabolic Toxicity: Results with the Model Toxicants 4-Aminophenol and Cyclophosphamide SO JOURNAL OF BIOMOLECULAR SCREENING LA English DT Article DE metabolism; in vitro toxicology; high content analysis; co-culture; human hepatocytes; 3T3-L1 cells ID CYTOTOXIC METABOLITES; HEPATOCYTES AB In vitro models that accurately and rapidly assess hepatotoxicity and the effects of hepatic metabolism on nonliver cell types are needed by the U.S. Department of Defense and the pharmaceutical industry to screen compound libraries. Here, we report the first use of high content analysis on the Integrated Discrete Multiple Organ Co-Culture (IdMOC) system, a high-throughput method for such studies. We cultured 3T3-L1 cells in the presence and absence of primary human hepatocytes, and exposed the cultures to 4-aminophenol and cyclophosphamide, model toxicants that are respectively detoxified and activated by the liver. Following staining with calcein-AM, ethidium homodimer-1, and Hoechst 33342, high content analysis of the cultures revealed four cytotoxic endpoints: fluorescence intensities of calcein-AM and ethidium homodimer-1, nuclear area, and cell density. Using these endpoints, we observed that the cytotoxicity of 4-aminophenol in 3T3-L1 cells in co-culture was less than that observed for 3T3-L1 monocultures, consistent with the known detoxification of 4-aminophenol by hepatocytes. Conversely, cyclophosphamide cytotoxicity for 3T3-L1 cells was enhanced by co-culturing with hepatocytes, consistent with the known metabolic activation of this toxicant. The use of IdMOC plates combined with high content analysis is therefore a multi-endpoint, high-throughput capability for measuring the effects of metabolism on toxicity. C1 [Cole, Stephanie D.] CNR, Res Associate Program, Washington, DC 20418 USA. [Madren-Whalley, Janna S.; Dorsey, Russell; Salem, Harry] US Army Res Dev & Engn Command, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. [Li, Albert P.] Vitro ADMET Labs Inc, Columbia, MD USA. [Salem, Harry] Chem Secur Assessment Ctr, Dept Homeland Secur, Aberdeen Proving Ground, MD USA. RP Cole, SD (reprint author), 5183 Blackhawk Rd, Gunpowder, MD 21010 USA. EM stephanie.d.cole9.ctr@mail.mil OI Li, Albert/0000-0001-5772-6265 FU National Research Council Research (NRC); Defense Threat Reduction Agency's Chemical and Biological Defense Program FX The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was funded by the National Research Council Research (NRC) and the Defense Threat Reduction Agency's Chemical and Biological Defense Program while Stephanie Cole held an NRC Research Associateship Award at the Edgewood Chemical Biological Center. NR 14 TC 4 Z9 4 U1 1 U2 14 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1087-0571 EI 1552-454X J9 J BIOMOL SCREEN JI J. Biomol. Screen PD DEC PY 2014 VL 19 IS 10 BP 1402 EP 1408 DI 10.1177/1087057114550399 PG 7 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Chemistry, Analytical SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Chemistry GA AU2PX UT WOS:000345461400008 PM 25239051 ER PT J AU Boves, TJ Sperry, JH Comolli, K Weatherhead, PJ AF Boves, Than J. Sperry, Jinelle H. Comolli, Kristin Weatherhead, Patrick J. TI Brood parasitism of Black-capped Vireos: frontline and post-laying behavioral responses and effects on productivity SO JOURNAL OF FIELD ORNITHOLOGY LA English DT Article DE adaptive behavior; Brown-headed Cowbird; coevolution; Molothrus ater; nest abandonment; nest desertion; Vireo atricapilla ID BROWN-HEADED COWBIRDS; YELLOW WARBLER EGGS; NEST DESERTION; REPRODUCTIVE SUCCESS; CLUTCH ABANDONMENT; PREDATION RISK; MIGRATORY BIRD; BELLS VIREO; HOST; REMOVAL AB The cost of brood parasitism favors the evolution of host behaviors that reduce the risk or expense of being parasitized. Endangered Black-capped Vireos (Vireo atricapilla) have likely coexisted with brood-parasitic Brown-headed Cowbirds (Molothrus ater) for more than 10,000 yr, so it is likely that they have evolved anti-parasitic behaviors. We monitored naturally parasitized and non-parasitized vireo nests to evaluate factors that might explain parasitism risk and nest desertion behavior and also assessed whether behaviors that occurred after being parasitized improved reproductive output. Vireos reduced the risk of parasitism by initiating breeding early and nesting farther from open grasslands and edges of woody thickets. Post-laying, nest desertion was common (70% of parasitized nests) and increased with both the presence of at least one cowbird egg in nests and clutch reduction by cowbirds. After accounting for these cues, desertion was also more likely at nests located closer to cowbird foraging habitat and below potential cowbird vantage points. Despite its regularity, desertion did not appear to provide reproductive benefits to vireos. Instead, accepting cowbird eggs was a more effective strategy because 42% of cowbird eggs did not hatch. Furthermore, cowbird eggs were somehow ejected from at least three vireo nests. Our results suggest that Black-capped Vireos can behave in a variety of ways that reduce the impact of brood parasitism, with frontline behaviors appearing to provide the greatest benefit. Our results also suggest that habitat management should focus on providing Black-capped Vireos with adequate breeding habitat that provides access to safe nesting sites, and with high-quality wintering habitat that allows vireos to migrate and initiate nesting early. RESUMEN Parasitismo reproductivo en Vireo atricapilla: respuestas de conducta pre y post-puesta y su efecto en la productividad El costo del parasitismo reproductivo favorece la evolucion de la conducta del huesped para que de alguna manera reduzca el riesgo o el costo de ser parasitado. El Vireo (Vireo atricapilla) ha coexistido, por mas de 10,000 anos, con el Tordo pardo (Molothrus ater) que es un parasito reproductivo y es posible que haya desarrollado alguna conducta anti parasitica. Monitoreamos nidos no parasitados y otros parasitados para evaluar los factoras que puedan explicar el riesgo parasitico y la conducta de abandonar el nido, y tambien si la conducta llevada a cabo, luego de ser parasitado un nido, mejora el rendimiento reproductivo. Los vireos reducen el riesgo de ser parasitados comenzando a reproducirse temprano y anidando lejos de herbazales abiertos y bordes de matorrales. El abandono de nidos, luego de la puesta, fue algo comun (70% de los nidos parasitados) e incremento, con la presencia de al menos un huevo de tordo o la reduccion de la camada de parte del parasito (remocion de huevos). Luego de tomar estas pistas en consideracion, la probabilidad de desercion fue mayor en nidos mas cercanos a las areas de forrajeo de los tordos y bajo el potencial de ventaja de los tordos. Pese a su regularidad, la desercion de nidos no parece proveer de beneficio reproductivo a los vireos. El aceptar los huevos de tordo resulto ser una estrategia mas efectiva porque el 42% de estos no eclosionaron. Mas aun, los huevos de tordo fueron sacados del nido en al menos tres nidos de vireos. Nuestros resultados sugieren que los vireos pueden conducirse de varias formas que a su vez puede reducir el impacto de parasitismo reproductivo, y exhibir conductas noveles que parecen proveer gran beneficio. Nuestros datos tambien sugieren que el manejo de habitat debe enfocar en proveer a los vireos de habitat adecuado para anidar, de lugares mas seguros para reproducirse y habitat invernal de gran calidad, que le permita a estos migrar e iniciar temprano el anidamiento. C1 [Boves, Than J.] Arkansas State Univ, Dept Biol Sci, Jonesboro, AR 72401 USA. [Boves, Than J.; Comolli, Kristin] Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA. [Sperry, Jinelle H.] Engineer Res & Dev Ctr, Champaign, IL 61826 USA. [Weatherhead, Patrick J.] Univ Illinois, Program Ecol Evolut & Conservat Biol, Urbana, IL 61822 USA. RP Boves, TJ (reprint author), Arkansas State Univ, Dept Biol Sci, Jonesboro, AR 72401 USA. EM tboves@astate.edu FU U.S. Army; Army Corps of Engineers, Engineer Research and Development Center; United States Geological Survey [12052] FX Funding for this project was provided by the U.S. Army through an agreement between the Natural Resources Management Branch at Fort Hood, U.S. Army ERDC, and University of Illinois Urbana-Champaign. Additional support was provided by Army Corps of Engineers, Engineer Research and Development Center. We thank T. Buchanan and T. Hayden for help in arranging funding. We thank J. A. Kutylowski and several other biologists for field assistance. We thank G. Ritchison and two anonymous reviewers for comments that greatly improved the manuscript. Banding was conducted under the auspices of United States Geological Survey, permit #12052. NR 70 TC 2 Z9 2 U1 4 U2 39 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0273-8570 EI 1557-9263 J9 J FIELD ORNITHOL JI J. Field Ornithol. PD DEC PY 2014 VL 85 IS 4 BP 364 EP 378 DI 10.1111/jofo.12076 PG 15 WC Ornithology SC Zoology GA AU4IE UT WOS:000345573200003 ER PT J AU Cardile, AP Sanchez, CJ Hardy, SK Romano, DR Hurtgen, BJ Wenke, JC Murray, CK Akers, KS AF Cardile, Anthony P. Sanchez, Carlos J., Jr. Hardy, Sharanda K. Romano, Desiree R. Hurtgen, Brady J. Wenke, Joseph C. Murray, Clinton K. Akers, Kevin S. TI Dakin solution alters macrophage viability and function SO JOURNAL OF SURGICAL RESEARCH LA English DT Article DE Sodium hypochlorite; Dakin solution; Macrophages; Phagocytosis ID TOPICAL ANTIMICROBIAL AGENTS; SODIUM-HYPOCHLORITE; DERMAL FIBROBLASTS; IN-VITRO; INFECTIONS; TOXICITY; CELLS; POLYMORPHONUCLEAR; ASPERGILLUS; MONONUCLEAR AB Background: Macrophages are important in wound defense and healing. Dakin's solution (DS), buffered sodium hypochlorite, has been used since World War I as a topical antimicrobial for wound care. DS has been shown to be toxic to host cells, but effects on immune cells are not well documented. Materials and methods: DS at 0.5%, 0.125%, and ten-fold serial dilutions from 0.25%-0.00025% were evaluated for cellular toxicity on murine macrophages (J774A.1). The effect of DS on macrophage adhesion, phagocytosis, and generation of reactive oxygen species was examined. Macrophage polarization following DS exposure was determined by gene expression using quantitative real-time polymerase chain reaction. Results: Concentrations of DS >0.0025% reduced macrophage viability to <5% in exposure times as short as 30 s. Similarly, phagocytosis of Staphylococcus aureus, Pseudomonas aeruginosa, and Aspergillus flavus were significantly reduced at all tested concentrations by macrophages pretreated with DS. H2O2 production was reduced by 8%-38% following treatment with 0.00025%-0.125% DS. Macrophage adherence was significantly increased with >0.0025% DS after 15 min of exposure compared with controls. Quantitative real-time polymerase chain reaction demonstrated that DS exposure resulted in classical macrophage activation, with increased expression of inducible nitric oxide synthase 2, interferon-gamma, and interleukin (IL)-1 beta. Conclusions: DS at clinically used concentrations (0.025%-0.25%) was detrimental to macrophage survival and function. For optimal clinical use, understanding the impact of DS on macrophages is important as depletion may result in impaired pathogen clearance and delayed healing. These findings indicate that 0.00025% DS is a safe starting dose; however, optimal use of DS requires further validation with in vivo models. Published by Elsevier Inc. C1 [Cardile, Anthony P.; Murray, Clinton K.; Akers, Kevin S.] Brooke Army Med Ctr, Infect Dis Serv MCHE MDI, Houston, TX 78234 USA. [Sanchez, Carlos J., Jr.; Hardy, Sharanda K.; Romano, Desiree R.; Hurtgen, Brady J.; Wenke, Joseph C.; Akers, Kevin S.] US Army Inst Surg Res, Dept Extrem Trauma & Regenerat Med, Houston, TX 78234 USA. RP Cardile, AP (reprint author), Brooke Army Med Ctr, Infect Dis Serv MCHE MDI, 3551 Roger Brooke Dr,JBSA Ft Sam, Houston, TX 78234 USA. EM anthony.p.cardile.mil@mail.mil FU National Research Council; Combat Casualty Research Program, Medical Research and Material Command FX C.J.S. and B.J.H. are supported through a post-doctoral research fellowship through National Research Council. Portions of this work were presented at the 2013 IDSA Annual Meeting, San Francisco, CA in October 2013. This work was supported by intramural funding from the Combat Casualty Research Program, Medical Research and Material Command to J.C.W. NR 39 TC 1 Z9 1 U1 0 U2 6 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-4804 EI 1095-8673 J9 J SURG RES JI J. Surg. Res. PD DEC PY 2014 VL 192 IS 2 BP 692 EP 699 DI 10.1016/j.jss.2014.07.019 PG 8 WC Surgery SC Surgery GA AU2BA UT WOS:000345419900064 PM 25130774 ER PT J AU Chandler, MQ Allison, PG Rodriguez, RI Moser, RD Kennedy, AJ AF Chandler, Mei Qiang Allison, Paul G. Rodriguez, Rogie I. Moser, Robert D. Kennedy, Alan J. TI Finite element modeling of multilayered structures of fish scales SO JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS LA English DT Article DE Atractosteus spatula; Polypterus senegalus; Multilayered structure; Finite element; Fracture ID MECHANICAL-PROPERTIES; LAMINATE STRUCTURE; ARAPAIMA-GIGAS; RESISTANCE AB The interlinked fish scales of Atractosteus spatula (alligator gar) and Polypterus senegalus (gray and albino bichir) are effective multilayered armor systems for protecting fish from threats such as aggressive conspecific interactions or predation. Both types of fish scales have multi-layered structures with a harder and stiffer outer layer, and softer and more compliant inner layers. However, there are differences in relative layer thickness, property mismatch between layers, the property gradations and nanostructures in each layer. The fracture paths and patterns of both scales under microindentation loads were different. In this work, finite element models of fish scales of A. spatula and P. senegalus were built to investigate the mechanics of their multilayered structures under penetration loads. The models simulate a rigid microindenter penetrating the fish scales quasi-statically to understand the observed experimental results. Study results indicate that the different fracture patterns and crack paths observed in the experiments were related to the different stress fields caused by the differences in layer thickness, and spatial distribution of the elastic and plastic properties in the layers, and the differences in interface properties. The parametric studies and experimental results suggest that smaller fish such as P. senegalus may have adopted a thinner outer layer for light-weighting and improved mobility, and meanwhile adopted higher strength and higher modulus at the outer layer, and stronger interface properties to prevent ring cracking and interface cracking, and larger fish such as A. spatula and Arapaima gigas have lower strength and lower modulus at the outer layers and weaker interface properties, but have adopted thicker outer layers to provide adequate protection against ring cracking and interface cracking, possibly because weight is less of a concern relative to the smaller fish such as P. senegalus. Published by Elsevier Ltd. C1 [Chandler, Mei Qiang; Moser, Robert D.; Kennedy, Alan J.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Allison, Paul G.; Rodriguez, Rogie I.] Univ Alabama, Dept Mech Engn, Tuscaloosa, AL 35487 USA. RP Chandler, MQ (reprint author), US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM Mei.Q.Chandler@usace.army.mil OI Allison, Paul/0000-0002-9041-237X FU US Army Engineer Research and Development Center (ERDC) Military Engineering 6.1 Basic Research Program FX The authors acknowledge the financial support for this work provided by the US Army Engineer Research and Development Center (ERDC) Military Engineering 6.1 Basic Research Program. Permission to publish was granted by the Director, ERDC Geotechnical and Structures Laboratory. NR 18 TC 4 Z9 4 U1 2 U2 16 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1751-6161 EI 1878-0180 J9 J MECH BEHAV BIOMED JI J. Mech. Behav. Biomed. Mater. PD DEC PY 2014 VL 40 BP 375 EP 389 DI 10.1016/j.jmbbm.2014.09.013 PG 15 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA AU2SU UT WOS:000345468700037 PM 25300062 ER PT J AU Scott, DJ Watson, JDB Heafner, TA Clemens, MS Propper, BW Arthurs, ZM AF Scott, Daniel J. Watson, J. Devin B. Heafner, Thomas A. Clemens, Michael S. Propper, Brandon W. Arthurs, Zachary M. TI Validation of the Short Musculoskeletal Function Assessment in patients with battlefield-related extremity vascular injuries SO JOURNAL OF VASCULAR SURGERY LA English DT Article; Proceedings Paper CT Vascular Annual Meeting of the Society-for-Vascular-Surgery / Spring Meeting of the Vascular-and-Endovascular-Surgery-Society CY JUN 04-07, 2014 CL Boston, MA SP Soc Vasc Surg, Vasc & Endovascular Surg Soc ID FUNCTION ASSESSMENT QUESTIONNAIRE; CROSS-CULTURAL ADAPTATION; HEALTH SURVEY SF-36; PENETRATING FEMOROPOPLITEAL INJURY; FUNCTION ASSESSMENT SMFA; DAMAGE CONTROL ADJUNCT; MODERN WARFARE; VALIDITY; OUTCOMES; RESPONSIVENESS AB Objective: Vascular extremity injuries can be a significant burden on a patient's long-term quality of life. Currently, no limb-specific surveys have been used to quantify the relation between injury pattern and the resultant physical or psychological impact. The objective of this study was to validate the use of the Short Musculoskeletal Function Assessment (SMFA) in the setting of extremity vascular injury. Methods: The Joint Theater Trauma Registry was queried and filtered for U.S. troops with an extremity vascular injury isolated to a single limb. Injury and management data were obtained, and the SMFA was administered after patient contact and consent. Validity was analyzed by characterization of SMFA score distribution, correlation with 36-Item Short Form Health Survey (SF-36) scores, and assessment of its discriminative capability to external measures of injury severity (ie, Injury Severity Score [ISS], Mangled Extremity Severity Score [MESS], and Medicare Part A disability qualification). Results: At mean follow-up of 5 years, 164 patients (median age, 25 years; interquartile range, 22-31 years) completed both surveys. The overall SMFA Dysfunction Index was 24.8 +/- 15.2 (range, 0-78; skewness, 0.60; floor/ceiling effect, 0%-1.2%; and nonresponse, 0%), and the overall Bother Index was 29.4 +/- 20.2 (range, 0-96; skewness, 0.58; floor/ceiling effect, 0%-4.3%; and nonresponse, 0.6%). SF-36 physical component summary scores correlated inversely with the Dysfunction Index (r = -0.64; P < .01), whereas mental component summary scores correlated inversely with the Bother Index (r = -0.59; P < .01). No difference was found in reported scores between those considered severely injured (ISS > 15) and those not severely injured (ISS <= 15). However, those with mangled extremities (MESS >= 7) reported higher Dysfunction and Bother indices than those with lower scores (P < .05). In addition, patients considered disabled (per Medicare Part A qualifications) reported higher Dysfunction and Bother indices compared with those not considered disabled (P < .05). Conclusions: Use of the SMFA is validated in those with extremity vascular injuries, and it should be considered an adjunctive tool in evaluating long-term patient outcomes. C1 [Scott, Daniel J.; Watson, J. Devin B.; Heafner, Thomas A.; Propper, Brandon W.] Lackland AFB, Clin Res Div 59, San Antonio, TX USA. [Scott, Daniel J.; Watson, J. Devin B.; Heafner, Thomas A.; Clemens, Michael S.; Propper, Brandon W.; Arthurs, Zachary M.] US Army, Inst Surg Res, Chambers Pass, Ft Sam Houston, TX 78234 USA. RP Scott, DJ (reprint author), San Antonio Mil Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM danscott34@gmail.com NR 34 TC 1 Z9 1 U1 0 U2 4 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD DEC PY 2014 VL 60 IS 6 BP 1620 EP 1626 DI 10.1016/j.jvs.2014.08.060 PG 7 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA AU3MX UT WOS:000345518600030 PM 25242269 ER PT J AU Milner, JL Abu-Farha, F Kurfess, T Hammond, VH AF Milner, Justin L. Abu-Farha, Fadi Kurfess, Thomas Hammond, Vincent H. TI Effects of induced shear deformation on microstructure and texture evolution in CP-Ti rolled sheets SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Titanium; Shear rolling; Texture; Stretch formability; Digital image correlation ID SEVERE PLASTIC-DEFORMATION; AZ31 MAGNESIUM ALLOY; BONDING ARB PROCESS; MECHANICAL-PROPERTIES; PURE TITANIUM; GRAIN-REFINEMENT; ALUMINUM; RECRYSTALLIZATION; IMPROVEMENT; DUCTILITY AB Commercial pure titanium sheets were deformed by shear rolling at 400 degrees C with subsequent annealing to investigate microstructure and texture evolution along with its effects on the mechanical properties. A four sheet multilayer rolling scheme was used to isolate shear strains within the outer sheets, termed isolated shear rolling (ISR), thus allowing for direct comparison between shear strained material (outer sheets) and plane-strained material under similar conditions. Microstructure and texture evolution were investigated by electron backscatter diffraction analysis, while mechanical properties were evaluated through tensile testing aided by digital image correlation (DIC). Texture was seen to evolve from a +/- 30 degrees transverse direction (TD) split basal texture to primarily basal texture ((0001)//Normal Direction) for the shear-strained sheets, in comparison with a slight rotation to a +/- 20 degrees TD-split for the plane-strained sheets. After short-term annealing at 600 degrees C for 15 min, texture remained similar to that of the as-processed material yet at lower intensity levels. Compared to the base material, shear-rolled material showed much higher Lankford Coefficient values, with a significant boost attributed to shear deformation. The greater stretch formability is achieved in the shear-rolled material by rotation of the basal poles to become parallel to the sheet thickness. The results obtained here with ISR in regards to the effects of inducing higher shear strains on the rolled material are comparable to those reported in the literature by differential speed rolling (DSR). (C) 2014 Elsevier B.V. All rights reserved. C1 [Milner, Justin L.; Abu-Farha, Fadi] Clemson Univ, Dept Automot Engn, Greenville, SC 29607 USA. [Kurfess, Thomas] Georgia Inst Technol, Sch Mech Engn, Atlanta, GA 30332 USA. [Hammond, Vincent H.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Abu-Farha, F (reprint author), Clemson Univ, Dept Automot Engn, Greenville, SC 29607 USA. EM FADI@clemson.edu FU U.S. Army Research Laboratory [W911NF-10-1-0413] FX The authors are grateful to RTI International Metals for providing access to the rolling mill using which all the ISR runs reported in this work were performed. All the electron microscopy work was performed at the Advanced Material Research Lab (AMRL) of Clemson University; the efforts of their team are greatly appreciated. This work was supported in part by the U.S. Army Research Laboratory under Grant number W911NF-10-1-0413. NR 30 TC 2 Z9 2 U1 5 U2 26 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 EI 1873-4936 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD DEC 1 PY 2014 VL 619 BP 12 EP 25 DI 10.1016/j.msea.2014.09.004 PG 14 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA AU2TD UT WOS:000345469500002 ER PT J AU Busey, B Berry-Caban, CS Hoedebecke, K Barts, RN AF Busey, Blake Berry-Caban, Cristobal S. Hoedebecke, Kyle Barts, Rachel N. TI A Rare Case of Moyamoya Disease in a 20-year-old Puerto Rican Female US Soldier SO PUERTO RICO HEALTH SCIENCES JOURNAL LA English DT Article DE Moyamoya; Cerebrovascular occlusive disease; Ischemia AB Moyamoya disease is a progressive, occlusive pathology involving the cerebral vasculature with particular involvement of the circle of Willis and its tributaries. The cause of moyamoya disease is unknown, but is believed to be hereditary. Females 20 to 39 years old with moyamoya represent 0.5% of all acute cerebral ischemia and infarcts with risk factors including smoking, estrogen- containing birth control use, coagulopathy, neoplasm, and congenital malformation. This case reports on a 20-year-old Puerto Rican female U.S. soldier with a 1-year history of migraine headaches with worsening right retro-orbital pain, blurred vision, and photophobia. The patient had minimal unilateral neurological deficits despite evidence of significant cerebral infarction on non-contrast computed tomography. Other neuroimaging findings were consistent with moyamoya disease with confirmation via cerebral angiography. This case details the process of diagnosis and treatment as well as discussing its incidence, identification, and treatment options. C1 [Busey, Blake] Soldier Family Med Ctr, Ft Bliss, TX USA. [Berry-Caban, Cristobal S.; Barts, Rachel N.] Womack Army Med Ctr, Dept Clin Invest, Ft Bragg, NC 28310 USA. [Hoedebecke, Kyle] 82nd Combat Aviat Brigade, Ft Bragg, NC USA. RP Berry-Caban, CS (reprint author), Womack Army Med Ctr, Dept Clin Invest, 2817 Reilly Rd, Ft Bragg, NC 28310 USA. EM cristobal.s.berry-caban.civ@mail.mil NR 12 TC 0 Z9 0 U1 0 U2 0 PU UNIV PUERTO RICO MEDICAL SCIENCES CAMPUS PI SAN JUAN PA OFFICE DEAN ACADEMIC AFFAIRS BOX 365067, SAN JUAN, PR 00936-5067 USA SN 0738-0658 J9 P R HEALTH SCI J JI P. R. Health Sci. J. PD DEC PY 2014 VL 33 IS 4 BP 197 EP 199 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AU3QS UT WOS:000345529300008 PM 25563038 ER PT J AU Carlisle, P Silliman, D Talley, A Tucker, D Hale, R Guelcher, S Baer, PB AF Carlisle, P. Silliman, D. Talley, A. Tucker, D. Hale, R. Guelcher, S. Baer, P. Brown TI Localized Low Dose rhBMP-2 Is Effective at Promoting Bone Regeneration in a Pre-Clinical Mandibular Segmental Defect Model SO TISSUE ENGINEERING PART A LA English DT Meeting Abstract CT TERMIS-AM Conference CY DEC 13-16, 2014 CL Washington, DC SP TERMIS AM C1 [Carlisle, P.; Silliman, D.; Tucker, D.; Hale, R.; Baer, P. Brown] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Talley, A.; Guelcher, S.] Vanderbilt Univ, Sch Engn, Nashville, TN 37235 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1937-3341 EI 1937-335X J9 TISSUE ENG PT A JI Tissue Eng. Part A PD DEC 1 PY 2014 VL 20 SU 1 MA O-246 BP S19 EP S19 PG 1 WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology SC Cell Biology; Biotechnology & Applied Microbiology GA AU6AK UT WOS:000345684300066 ER PT J AU Guo, R Ward, C Nanney, L Guelcher, S AF Guo, R. Ward, C. Nanney, L. Guelcher, S. TI An Injectable and Settable Cell Delivery System Derived from In Situ Chemical Polymerization Promotes Healing in a Porcine Full-Thickness Excisional Wound Model SO TISSUE ENGINEERING PART A LA English DT Meeting Abstract CT TERMIS-AM Conference CY DEC 13-16, 2014 CL Washington, DC SP TERMIS AM C1 [Guo, R.; Nanney, L.; Guelcher, S.] Vanderbilt Univ, Nashville, TN 37235 USA. [Ward, C.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1937-3341 EI 1937-335X J9 TISSUE ENG PT A JI Tissue Eng. Part A PD DEC 1 PY 2014 VL 20 SU 1 MA P-195 BP S70 EP S71 PG 2 WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology SC Cell Biology; Biotechnology & Applied Microbiology GA AU6AK UT WOS:000345684300273 ER PT J AU Roy, D Kowalczewski, C Hall, R Burnett, L Tomblyn, S Saul, J Christy, R AF Roy, D. Kowalczewski, C. Hall, R. Burnett, L. Tomblyn, S. Saul, J. Christy, R. TI Antibiotic-Loaded Keratin Hydrogels Prevent Infection in a Full-Thickness Porcine Excision Wound SO TISSUE ENGINEERING PART A LA English DT Meeting Abstract CT TERMIS-AM Conference CY DEC 13-16, 2014 CL Washington, DC SP TERMIS AM C1 [Roy, D.; Christy, R.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Kowalczewski, C.; Hall, R.; Saul, J.] Miami Univ, Oxford, OH 45056 USA. [Burnett, L.; Tomblyn, S.] KeraNetics, Winston Salem, NC USA. NR 0 TC 0 Z9 0 U1 2 U2 4 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1937-3341 EI 1937-335X J9 TISSUE ENG PT A JI Tissue Eng. Part A PD DEC 1 PY 2014 VL 20 SU 1 MA P-148 BP S64 EP S64 PG 1 WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology SC Cell Biology; Biotechnology & Applied Microbiology GA AU6AK UT WOS:000345684300245 ER PT J AU Silliman, D Carlisle, P Owens, D Tucker, D Hale, R BrownBaer, P AF Silliman, D. Carlisle, P. Owens, D. Tucker, D. Hale, R. BrownBaer, P. TI Segmental Mandibular Defects in Sinclair Miniature Pigs Mimic Human Mandibular Reconstruction Cases SO TISSUE ENGINEERING PART A LA English DT Meeting Abstract CT TERMIS-AM Conference CY DEC 13-16, 2014 CL Washington, DC SP TERMIS AM C1 [Silliman, D.; Carlisle, P.; Owens, D.; Tucker, D.; Hale, R.; BrownBaer, P.] US Army Inst Surg Res, JBSA Ft Sam Houston, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1937-3341 EI 1937-335X J9 TISSUE ENG PT A JI Tissue Eng. Part A PD DEC 1 PY 2014 VL 20 SU 1 MA P-244 BP S77 EP S78 PG 2 WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology SC Cell Biology; Biotechnology & Applied Microbiology GA AU6AK UT WOS:000345684300302 ER PT J AU Wang, H Kaini, RR Burke, TA Golden, DJ Johnson, AJ AF Wang, H. Kaini, R. R. Burke, T. A. Golden, D. J. Johnson, A. J. TI Matrix Proteins and Retina Development in a 3D In Vitro System SO TISSUE ENGINEERING PART A LA English DT Meeting Abstract CT TERMIS-AM Conference CY DEC 13-16, 2014 CL Washington, DC SP TERMIS AM C1 [Wang, H.; Kaini, R. R.; Johnson, A. J.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX USA. [Burke, T. A.; Golden, D. J.] Cherokee Nation Businesses, Jbsa Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1937-3341 EI 1937-335X J9 TISSUE ENG PT A JI Tissue Eng. Part A PD DEC 1 PY 2014 VL 20 SU 1 MA O-271 BP S21 EP S22 PG 2 WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology SC Cell Biology; Biotechnology & Applied Microbiology GA AU6AK UT WOS:000345684300077 ER PT J AU Wehmeyer, JL Lund, BJ Edsall, PR Zamora, DO AF Wehmeyer, J. L. Lund, B. J. Edsall, P. R. Zamora, D. O. TI Development of a Novel Method for the De-Epithelialization of Amniotic Membrane SO TISSUE ENGINEERING PART A LA English DT Meeting Abstract CT TERMIS-AM Conference CY DEC 13-16, 2014 CL Washington, DC SP TERMIS AM C1 [Wehmeyer, J. L.; Lund, B. J.; Edsall, P. R.; Zamora, D. O.] US Army Inst Surg Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1937-3341 EI 1937-335X J9 TISSUE ENG PT A JI Tissue Eng. Part A PD DEC 1 PY 2014 VL 20 SU 1 MA P-562 BP S118 EP S118 PG 1 WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology SC Cell Biology; Biotechnology & Applied Microbiology GA AU6AK UT WOS:000345684300464 ER PT J AU Reiter, MJ Schwope, RB Lisanti, CJ AF Reiter, Michael J. Schwope, Ryan B. Lisanti, Christopher J. TI Algorithmic approach to solid adnexal masses and their mimics: utilization of anatomic relationships and imaging features to facilitate diagnosis SO ABDOMINAL IMAGING LA English DT Article DE Solid adnexal mass; Ovarian cancer; Uterine leiomyoma; US; CT; MRI ID GASTROINTESTINAL STROMAL TUMORS; MULLERIAN DUCT ANOMALIES; NERVE SHEATH TUMORS; GERM-CELL TUMORS; PELVIC MASSES; PATHOLOGICAL CORRELATION; COMPUTED-TOMOGRAPHY; OVARIAN TERATOMAS; CT; MRI AB Solid adnexal masses, while less common than their cystic counterparts, may present a challenge for radiologists given the wide range of histologic entities that occur in this region. Pelvic masses, especially when large, can seem overwhelming at first but application of an algorithmic approach allows for more confident assessment. This approach focuses first on the use of anatomic relationships and interactions of various pelvic structures to localize the mass' origin. For instance, the directionality of ureteral displacement can suggest if a mass is intra or extraperitoneal. Then, key discriminating imaging features, such as the presence of fat, hypervascularity, or low T2 signal on magnetic resonance imaging (MRI) can be applied to further narrow the list of diagnostic possibilities. Entities such as leiomyomas, nerve sheath tumors, congenital uterine anomalies, and vascular abnormalities (ovarian torsion or iliac vessel aneurysm) in particular are often accurately characterized with sonography and/or MRI. For solid adnexal masses in which a definitive diagnosis by imaging is not reached, information germane to clinicians regarding further management can still be provided, principally with regard to surgical vs. nonsurgical treatment. C1 [Reiter, Michael J.; Schwope, Ryan B.; Lisanti, Christopher J.] Brooke Army Med Ctr, Dept Radiol, San Antonio, TX 78234 USA. [Reiter, Michael J.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Reiter, MJ (reprint author), Brooke Army Med Ctr, Dept Radiol, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA. EM mikereiter13@yahoo.com NR 64 TC 1 Z9 1 U1 1 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0942-8925 EI 1432-0509 J9 ABDOM IMAGING JI Abdom. Imaging PD DEC PY 2014 VL 39 IS 6 BP 1284 EP 1296 DI 10.1007/s00261-014-0163-4 PG 13 WC Gastroenterology & Hepatology; Radiology, Nuclear Medicine & Medical Imaging SC Gastroenterology & Hepatology; Radiology, Nuclear Medicine & Medical Imaging GA AT5SW UT WOS:000345003100019 PM 24852312 ER PT J AU Bulzacchelli, MT Sulsky, SI Rodriguez-Monguio, R Karlsson, LH Hill, OT AF Bulzacchelli, Maria T. Sulsky, Sandra I. Rodriguez-Monguio, Rosa Karlsson, Lee H. Hill, Owen T. TI Injury During US Army Basic Combat Training A Systematic Review of Risk Factor Studies SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Review ID EXERCISE-RELATED INJURIES; STRESS-FRACTURES; YOUNG MEN; MILITARY; RECRUITS; PREVENTION; TRAINEES; INTERVENTIONS; WOMEN; RATES AB Context: Approximately one quarter of men and half of women in U.S. Army basic combat training experience an injury. Preventing basic combat training-related injuries would reduce associated human and economic costs and discharges from the Army. Identification of risk factors for such injuries is a crucial step toward their prevention. Although some research has begun to address this need, prior studies of risk factors for training-related injury have not been reviewed systematically. This study systematically reviews the literature on risk factors for injury during U.S. Army basic combat training. Evidence acquisition: Original studies of risk factors for injury during U.S. Army basic combat training published since 1990 in peer-reviewed journals were identified using PubMed and manual searches of reference lists. This search was last performed in May 2013. Nineteen studies met the inclusion criteria. Evidence synthesis: Methodologic quality and potential for bias were assessed. The findings of 11 studies deemed to be of high or medium quality were synthesized to determine the level of evidence supporting the association between each risk factor studied and risk of injury during basic combat training. Quality assessment and evidence synthesis were performed from June to September 2013. Conclusions: There is strong or moderate evidence supporting association of older age, history of smoking, and self-rated low physical activity level prior to basic combat training with increased risk of training-related injury among male trainees. There is limited, mixed, or insufficient evidence to identify risk factors for injury among female trainees. (C) 2014 American Journal of Preventive Medicine. All rights reserved. C1 [Bulzacchelli, Maria T.; Rodriguez-Monguio, Rosa] Univ Massachusetts, Dept Publ Hlth, Amherst, MA 01003 USA. [Sulsky, Sandra I.; Karlsson, Lee H.] ENVIRON Int Corp, Amherst, MA USA. [Hill, Owen T.] US Army Res Inst Environm Med, Natick, MA USA. RP Bulzacchelli, MT (reprint author), Univ Massachusetts, Dept Publ Hlth, 715 N Pleasant St, Amherst, MA 01003 USA. EM bulzacchelli@schoolph.umass.edu FU U.S. Army Medical Research Materiel Command [W911QY-10-C-0194]; U.S. Army Research Institute of Environmental Medicine FX This work was supported by the U.S. Army Medical Research Materiel Command, under Contract No. W911QY-10-C-0194, in collaboration with the U.S. Army Research Institute of Environmental Medicine. NR 37 TC 6 Z9 6 U1 2 U2 10 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 EI 1873-2607 J9 AM J PREV MED JI Am. J. Prev. Med. PD DEC PY 2014 VL 47 IS 6 BP 813 EP 822 DI 10.1016/j.amepre.2014.08.008 PG 10 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA AT9RP UT WOS:000345264200015 PM 25455122 ER PT J AU Saunders, D Vanachayangkul, P Imerbsin, R Khemawoot, P Siripokasupkul, R Tekwani, BL Sampath, A Nanayakkara, NPD Ohrt, C Lanteri, C Gettyacamin, M Teja-Isavadharm, P Walker, L AF Saunders, David Vanachayangkul, Pattaraporn Imerbsin, Rawiwan Khemawoot, Phisit Siripokasupkul, Raveewan Tekwani, Babu L. Sampath, Aruna Nanayakkara, N. P. Dhammika Ohrt, Colin Lanteri, Charlotte Gettyacamin, Montip Teja-Isavadharm, Paktiya Walker, Larry TI Pharmacokinetics and Pharmacodynamics of (+)-Primaquine and (-)-Primaquine Enantiomers in Rhesus Macaques (Macaca mulatta) SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID PLACEBO-CONTROLLED TRIAL; PLASMODIUM-VIVAX MALARIA; MAJOR PLASMA METABOLITE; PRIMAQUINE ENANTIOMERS; PROPHYLAXIS; DRUG; 8-AMINOQUINOLINES; CARBOXYPRIMAQUINE; METHEMOGLOBINEMIA; SUSCEPTIBILITY AB Primaquine (PQ) remains the sole available drug to prevent relapse of Plasmodium vivax malaria more than 60 years after licensure. While this drug was administered as a racemic mixture, prior studies suggested a pharmacodynamic advantage based on differential antirelapse activity and/or toxicities of its enantiomers. Oral primaquine enantiomers prepared using a novel, easily scalable method were given for 7 days to healthy rhesus macaques in a dose-rising fashion to evaluate their effects on the blood, liver, and kidneys. The enantiomers were then administered to Plasmodium cynomolgi-infected rhesus macaques at doses of 1.3 and 0.6 mg/kg of body weight/day in combination with chloroquine. The (-)-PQ enantiomer had higher clearance and apparent volume of distribution than did (+)-PQ and was more extensively converted to the carboxy metabolite. There is evidence for differential oxidative stress with a concentration-dependent rise in methemoglobin (MetHgb) with increasing doses of (+)-PQ greater than that seen for (-)-PQ. There was a marked, reversible hepatotoxicity in 2 of 3 animals dosed with (-)-PQ at 4.5 mg/kg. (-)-PQ in combination with chloroquine was successful in preventing P. cynomolgi disease relapse at doses of 0.6 and 1.3 mg/kg/day, while 1 of 2 animals receiving (+)-PQ at 0.6 mg/kg/day relapsed. While (-)-PQ was also associated with hepatotoxicity at higher doses as seen previously, this has not been identified as a clinical concern in humans during >60 years of use. Limited evidence for increased MetHgb generation with the (+) form in the rhesus macaque model suggests that it may be possible to improve the therapeutic window for hematologic toxicity in the clinic by separating primaquine into its enantiomers. C1 [Saunders, David; Vanachayangkul, Pattaraporn; Khemawoot, Phisit; Siripokasupkul, Raveewan; Lanteri, Charlotte; Teja-Isavadharm, Paktiya] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. [Imerbsin, Rawiwan; Gettyacamin, Montip] Armed Forces Res Inst Med Sci, Dept Vet Med, Bangkok 10400, Thailand. [Tekwani, Babu L.; Sampath, Aruna; Nanayakkara, N. P. Dhammika; Walker, Larry] Univ Mississippi, Natl Ctr Nat Prod Res, Oxford, MS USA. [Tekwani, Babu L.; Walker, Larry] Univ Mississippi, Sch Pharm, Dept Pharmacol, Oxford, MS USA. [Ohrt, Colin] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. RP Saunders, D (reprint author), Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. EM David.Saunders@AFRIMS.org NR 32 TC 3 Z9 3 U1 3 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD DEC PY 2014 VL 58 IS 12 BP 7283 EP 7291 DI 10.1128/AAC.02576-13 PG 9 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA AT9AW UT WOS:000345221000030 PM 25267666 ER PT J AU Hawkins, AD Thornton, C Steevens, JA Willett, KL AF Hawkins, Adam D. Thornton, Cammi Steevens, Jeffery A. Willett, Kristine L. TI ALTERATION IN PIMEPHALES PROMELAS MUCUS PRODUCTION AFTER EXPOSURE TO NANOSILVER OR SILVER NITRATE SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Metal toxicology; Nanoparticles; Nanotoxicology; Silver ID TROUT ONCORHYNCHUS-MYKISS; RAINBOW-TROUT; TOXICITY; FISH; POLLUTION; STRESS; WATER AB The fish gill's ability to produce mucus effectively is a critical part of the stress response and protection against xenobiotic toxicity. Adult fathead minnows were exposed to silver nitrate (0.82 mu g/L or 13.2 mu g/L), polyvinylpyrrolidone-coated silver nanoparticles (11.1 mu g/L or 208 mu g/L), and citrate-coated silver nanoparticles (10.1 mu g/L or 175 mu g/L) for 96h. Mucus concentrations based on glucose as a surrogate were determined at 0h, 1h, 2h, 3h, 4 h and 24h after re-dosing each day. Higher mucus production rates following silver treatment were observed at the beginning as compared to controls and compared to after 3d of exposure. Control fish produced consistent mucus concentrations throughout the exposure (0.62mg/L and 0.40mg/L at 24h and 96h, respectively). Following 24h of exposure, all silver treatment groups produced significantly more mucus than controls. Following 96h of exposure, mucus concentrations in treatment groups were significantly reduced compared with each respective treatment at 24h. Reduced mucus production following long-term silver exposure could prevent the gills from removing silver, and thus increase toxicity. Environ Toxicol Chem 2014;33:2869-2872. (c) 2014 SETAC C1 [Hawkins, Adam D.; Thornton, Cammi; Willett, Kristine L.] Univ Mississippi, Sch Pharm, Dept BioMol Sci, University, MS 38677 USA. [Hawkins, Adam D.; Thornton, Cammi; Willett, Kristine L.] Univ Mississippi, Sch Pharm, Environm Toxicol Res Program, University, MS 38677 USA. [Steevens, Jeffery A.] US Army, Environm Lab, Engn Res & Dev Ctr, Vicksburg, MS USA. RP Willett, KL (reprint author), Univ Mississippi, Sch Pharm, Dept BioMol Sci, University, MS 38677 USA. EM kwillett@olemiss.edu RI Geracitano, Laura/E-6926-2013 FU Army Corp of Engineers Engineer Research and Development Center [W912HZ-09-C-0033] FX We would like to thank F. Booc and K. Alharthy for assistance with water changes, feedings, and water sample collection, and A. Bednar for help with inductively coupled plasma-mass spectrometry analyses. This research is supported by Army Corp of Engineers Engineer Research and Development Center funding (#W912HZ-09-C-0033). NR 23 TC 2 Z9 2 U1 2 U2 11 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD DEC PY 2014 VL 33 IS 12 BP 2869 EP 2872 DI 10.1002/etc.2759 PG 4 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA AU0NE UT WOS:000345319100028 PM 25262928 ER PT J AU McAllister, QP Gillespie, JW VanLandingham, MR AF McAllister, Quinn P. Gillespie, John W., Jr. VanLandingham, Mark R. TI The energy dissipative mechanisms of particle-fiber interactions in a textile composite SO JOURNAL OF COMPOSITE MATERIALS LA English DT Article DE Kevlar; nanoindentation; nanoscratching; energy dissipation; textile composite ID FRAGMENT-CONTAINMENT APPLICATIONS; THICKENING-FLUID KEVLAR; BALLISTIC IMPACT ENERGY; YARN PULL-OUT; HIGH-STRENGTH; WOVEN FABRICS; TRANSVERSE COMPRESSION; ARAMID FABRICS; SINGLE-FIBER; PPTA FIBERS AB Nanoindentation and nanoscratch tests made on the surface of Kevlar KM2 fibers impart contact geometries similar to a typical contact between a particle and a fiber in a particle-infused fabric. In this study, the forces required for indentation and scratching are used as a measure of a single particle gouge of the surface of a Kevlar fiber. The gouging forces and a geometric model are used to calculate the apparent friction and energy associated with particle gouging during impact. The friction associated with particle gouging can be increased up to approximate to 240% compared to Kevlar yarn-yarn friction levels. The energy of gouging a distribution of particles is on the order of 10% of the energy required for axial tensile failure and 25% of the energy required for transverse compression of the fiber (for a limiting transverse strain of approximate to 0.3). The relative contributions of the friction and energy associated with particle gouging to the overall energy dissipated by a textile composite are discussed. C1 [McAllister, Quinn P.; Gillespie, John W., Jr.] Univ Delaware, Ctr Composite Mat, Dept Mat Sci & Engn, Newark, DE 19716 USA. [Gillespie, John W., Jr.] Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. [Gillespie, John W., Jr.] Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. [VanLandingham, Mark R.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD USA. RP McAllister, QP (reprint author), Univ Delaware, Ctr Composite Mat, Dept Mat Sci & Engn, Newark, DE 19716 USA. EM mcallq@gmail.com FU Army Research Laboratory [W911NF-06-2-0011, W911NF-12-2-0022] FX Research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Numbers W911NF-06-2-0011 and W911NF-12-2-0022. NR 46 TC 0 Z9 0 U1 3 U2 27 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0021-9983 EI 1530-793X J9 J COMPOS MATER JI J. Compos Mater. PD DEC PY 2014 VL 48 IS 28 BP 3553 EP 3567 DI 10.1177/0021998313511651 PG 15 WC Materials Science, Composites SC Materials Science GA AU0TH UT WOS:000345336900009 ER PT J AU Harris, JT Segall, AE Robinson, D Carter, R AF Harris, J. T. Segall, A. E. Robinson, D. Carter, R. TI Interfacial Flaw Evolution of Coatings Under Severe Thermal and Pressure Transients SO JOURNAL OF PRESSURE VESSEL TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article DE transient; thermal stress and strain; cylinder; cohesive zone ID BARRIER COATINGS; THERMOMECHANICAL CRACKING; DAMAGE; DELAMINATION; MECHANISMS; SUBSTRATE AB The effects of severe thermal and pressure transients on coated substrates with indentation-induced, blister defects were analyzed by experimental and finite element methods. Cohesive zone properties evaluated in a previous study were first used in an implicit indentation simulation. Indentation simulation results then served as the initial conditions for explicit modeling of interfacial flaw evolution due to the already determined thermal and pressure transients that included interstitial pressure in the defect. The thermal structural model was used to assess the transient thermal-and stress-states and the propensity for fracture related damage and evolution while undergoing severe convective heating and pressure loading analogous to gun tube conditions. Results illustrated the overall benefits of the in-phase applied pressure in terms of suppressing crack growth except when delayed interstitial loading was considered. Thermal capacitance was also studied and it was found that crack growth decreased significantly with higher specific heat and demonstrates the potential importance of coating thermophysical properties. C1 [Harris, J. T.; Segall, A. E.; Robinson, D.] Penn State Univ, University Pk, PA 16803 USA. [Carter, R.] US Army Res Lab, AMSRL WM MB, Aberdeen Proving Ground, MD 21005 USA. RP Harris, JT (reprint author), Penn State Univ, 212 EES Bldg, University Pk, PA 16803 USA. EM jth203@psu.edu; aesegall@psu.edu; rcarter@arl.army.mil FU Army Research Lab at the Department of Defense FX The authors would like to acknowledge the Army Research Lab at the Department of Defense for the funding that made this work possible. NR 22 TC 0 Z9 0 U1 2 U2 5 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0094-9930 EI 1528-8978 J9 J PRESS VESS-T ASME JI J. Press. Vessel Technol.-Trans. ASME PD DEC PY 2014 VL 136 IS 6 AR 061205 DI 10.1115/1.4025721 PG 8 WC Engineering, Mechanical SC Engineering GA AT8AD UT WOS:000345155300005 ER PT J AU Naito, C Beacraft, M Hoemann, J Shull, J Salim, H Bewick, B AF Naito, Clay Beacraft, Mark Hoemann, John Shull, Jonathan Salim, Hani Bewick, Bryan TI Blast Performance of Single-Span Precast Concrete Sandwich Wall Panels SO JOURNAL OF STRUCTURAL ENGINEERING LA English DT Article DE Blasting; Sandwich panels; Prestressed concrete; Composite beams; Dynamic tests; Sandwich panels; Prestressed concrete; Composite beams; Dynamic tests; Shock and vibratory effects AB A research program was conducted to assess the capability of conventional non-load-bearing insulated precast concrete exterior wall panels to withstand blast loadings. Typical construction details from the tilt-up and prestressed concrete industries were examined. The sensitivity of insulation type, reinforcement, foam thickness, and shear tie type on the flexural resistance was assessed. Forty-two single-span static experiments were conducted on 14 different panel designs. From the results of these experiments, resistance functions and deformation limits for insulated concrete sandwich panels were determined. The resistance functions were used to develop predictive dynamic models for panels subjected to blast demands. The models were found to be accurate in comparison to measurements from four full-scale blast detonations. The findings of the research indicate that both prestressed and non-prestressed insulated concrete wall panels meet current rotational limits defined by the U.S. Army Corps of Engineers for protective structures. Simplified methods for modeling the pressure-deformation characteristics of insulated panels can be used to approximate the peak dynamic deformation and reaction loads. C1 [Naito, Clay; Beacraft, Mark] Lehigh Univ, Dept Civil & Environm Engn, ATLSS Ctr, Bethlehem, PA 18015 USA. [Hoemann, John] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Hoemann, John] Air Force Res Lab, Tyndall AFB, FL USA. [Hoemann, John] Appl Res Associates Inc, Tyndall AFB, FL USA. [Shull, Jonathan] Black & Veatch Consulting Engineers, Fed Serv Div, Webb City, MO 64870 USA. [Salim, Hani] Univ Missouri, Dept Civil & Environm Engn, Columbia, MO 65211 USA. [Bewick, Bryan] Protect Engn Consultants, Austin, TX 78737 USA. [Bewick, Bryan] Air Force Res Lab, Panama City, FL 32403 USA. RP Naito, C (reprint author), Lehigh Univ, Dept Civil & Environm Engn, ATLSS Ctr, 117 ATLSS Dr, Bethlehem, PA 18015 USA. EM cjn3@lehigh.edu; mark.beacraft@gmail.com OI Naito, Clay/0000-0003-3835-8131 FU Air Force Research Laboratory [FA4918-07-D-0001, FA8903-08-D-8768] FX The authors thank the Air Force Research Laboratory (Dr. Robert Dinan and Dr. Michael Hammons, Program Managers) for funding this work under contracts FA4918-07-D-0001 and FA8903-08-D-8768. The experiments were performed at the Air Force Research Laboratory located at Tyndall AFB, FL, and at the University of Missouri - Columbia. The work was conducted under a Cooperative Research and Development Agreement (CRADA) between the Portland Cement Association, the Prestressed/Precast Concrete Institute, and the Tilt-Up Concrete Association. The authors also thank John Sullivan, Jason Krohn, Michael Sugrue, and the member companies of these organizations for technical and fabrication support of the research. In addition, the authors thank the Geotechnical and Structures Laboratory of the U.S. Army Corps of Engineers for efforts in revising this document. Citation of manufacturers or trade names does not constitute an official endorsement or approval of the use thereof. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon. NR 17 TC 1 Z9 1 U1 4 U2 30 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9445 EI 1943-541X J9 J STRUCT ENG JI J. Struct. Eng. PD DEC PY 2014 VL 140 IS 12 AR 04014096 DI 10.1061/(ASCE)ST.1943-541X.0001020 PG 13 WC Construction & Building Technology; Engineering, Civil SC Construction & Building Technology; Engineering GA AU0RE UT WOS:000345330900005 ER PT J AU Scalzitti, NJ Pfannenstiel, TJ AF Scalzitti, Nicholas J. Pfannenstiel, Travis J. TI A Lightning Strike Causing a Cholesteatoma: A Unique Form of Otologic Blast Injury SO OTOLOGY & NEUROTOLOGY LA English DT Article DE Blast injury; Cholesteatoma; Lightening ID TYMPANIC MEMBRANE; RARE-CAUSE; OVERPRESSURE; DISRUPTION; EAR AB Objective: We present a case of a middle-aged male struck by lightning while walking in a parking lot. Assessment of the patient's injuries demonstrated common sequelae of an otologic blast injury. Review of this case should prepare the otolaryngologist to identify and manage otologic blast injuries regardless of their etiology. Methods: Case study and literature review Case Report: The patient presented to a level 1 trauma and burn center with a ruptured tympanic membrane, otalgia, mixed hearing loss, dizziness, and tinnitus. After 3 months of observation, the patient's tympanic membrane perforation demonstrated little spontaneous closure. Additionally, he was noted to have formation of a posttraumatic cholesteatoma in the posterior-superior mesotympanum. Over-under tympanoplasty with excision of the cholesteatoma was successful, and the ossicular chain remained intact. The patient underwent vestibular therapy for an ipsilateral uncompensated vestibular weakness. His dizziness resolved, allowing him to return to full employment. The patient's final audiogram demonstrated normal hearing thresholds sloping to a mild mixed hearing loss in the high frequencies, and the tinnitus reduced significantly in intensity but did not resolve. Conclusion: The patient's injury pattern clearly resulted from the damaging effects of the shock wave generated by the lightning bolt, which impacted the patient's thorax. Management of his otologic care was conducted after practices developed for otologic blast injury and resulted in his being able to return to his primary occupation. C1 [Scalzitti, Nicholas J.; Pfannenstiel, Travis J.] Brooke Army Med Ctr, San Antonio, TX USA. RP Scalzitti, NJ (reprint author), JBSA Ft Sam, Dept Otolaryngol, 3551 Roger Brooke Dr, Houston, TX 78264 USA. EM nicholas.j.sclazitti.mil@mail.mil NR 9 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1531-7129 EI 1537-4505 J9 OTOL NEUROTOL JI Otol. Neurotol. PD DEC PY 2014 VL 35 IS 10 BP E298 EP E300 PG 3 WC Clinical Neurology; Otorhinolaryngology SC Neurosciences & Neurology; Otorhinolaryngology GA AT8AX UT WOS:000345157200006 PM 25111525 ER PT J AU Nenno, PT Wetzel, ED AF Nenno, Paul T. Wetzel, Eric D. TI Design and properties of a rate-dependent 'dynamic ligament' containing shear thickening fluid SO SMART MATERIALS AND STRUCTURES LA English DT Article DE shear thickening fluid; dynamic ligament; rate-dependent ID COLLOIDAL DISPERSIONS; BALLISTIC PERFORMANCE; BROWNIAN SUSPENSIONS; DENSE SUSPENSIONS; PARTICLE-SIZE; RHEOLOGY; FORCES AB A 'dynamic ligament' device that exhibits a discontinuous, rate-dependent tensile response is developed and characterized. The device, based on a shear thickening fluid (STF) and flexible ribbons enclosed in elastomeric tubing, exhibits low resistance to extension at rates below 10 mm s(-1), but when stretched at 100 mm s(-1) or higher resists with more than tenfold higher force. A link between the rheology of the STF and the tensile performance of the dynamic ligament is presented to explain the rate-dependent response. Visualization experiments show evidence of void formation and dilation in the STF during high rate extension. C1 [Nenno, Paul T.; Wetzel, Eric D.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Nenno, PT (reprint author), US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM eric.d.wetzel2.civ@mail.mil FU Oak Ridge Institute for Science and Education; Defense Advanced Research Projects Agency (DARPA) under the Warrior Web program (PI: LTC Joseph Hitt) FX This research was supported in part by an appointment to the Postgraduate Research Participation Program at the US Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and ARL. Seed funding to initiate the research was provided by the Defense Advanced Research Projects Agency (DARPA) under the Warrior Web program (PI: LTC Joseph Hitt). The authors also acknowledge supporting contributions from Anthony Pallanta, Dr Jeremy Fowler and Professor Norman Wagner at the University of Delaware. NR 31 TC 1 Z9 2 U1 0 U2 17 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0964-1726 EI 1361-665X J9 SMART MATER STRUCT JI Smart Mater. Struct. PD DEC PY 2014 VL 23 IS 12 AR 125019 DI 10.1088/0964-1726/23/12/125019 PG 10 WC Instruments & Instrumentation; Materials Science, Multidisciplinary SC Instruments & Instrumentation; Materials Science GA AT9WU UT WOS:000345275400020 ER PT J AU Zhang, H Cho, K Yen, CF Ravi-Chandar, K AF Zhang, H. Cho, K. Yen, C. F. Ravi-Chandar, K. TI Dynamic Crushing of Unidirectionally Reinforced Metal Matrix Composite SO STRAIN LA English DT Article DE dissipation; Hopkinson bar; kink band ID COMPRESSIVE FAILURE; FIBER COMPOSITES; ALUMINUM AB The strain rate-dependent response of Al2O3/Al composite is examined using a split-Hopkinson pressure bar apparatus. High-speed photography is used to establish that the strain develops inhomogeneously in the specimen due to the onset and propagation of a kink band. The power balance equation is exploited in order to determine the dissipation at the kink band. The mechanism of kink band is shown to be essentially unaltered, with only the amount of fibre fracture being influenced by the dynamic loading process. C1 [Zhang, H.] Schlumberger, Sugar Land, TX 77478 USA. [Cho, K.; Yen, C. F.] Army Res Lab, Aberdeen, MD USA. [Ravi-Chandar, K.] Univ Texas Austin, Ctr Mech Solids Struct & Mat, Austin, TX 78712 USA. RP Zhang, H (reprint author), Schlumberger, Sugar Land, TX 77478 USA. FU Army Research Office [W911NF-09-1-0331] FX This work was performed under a grant from the Army Research Office under grant number W911NF-09-1-0331. This support is gratefully acknowledged. NR 13 TC 0 Z9 0 U1 3 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1475-1305 J9 STRAIN JI Strain PD DEC PY 2014 VL 50 IS 6 SI SI BP 517 EP 526 DI 10.1111/str.12103 PG 10 WC Materials Science, Characterization & Testing SC Materials Science GA AT3YT UT WOS:000344872600004 ER PT J AU Wallace, RM Stanek, D Griese, S Krulak, D Vora, NM Pacha, L Kan, V Said, M Williams, C Burgess, TH Clausen, SS Austin, C Gabel, J Lehman, M Finelli, LN Selvaggi, G Joyce, P Gordin, F Benator, D Bettano, A Cersovsky, S Blackmore, C Jones, SV Buchanan, BD Fernandez, AI Dinelli, D Agnes, K Clark, A Gill, J Irmler, M Blythe, D Mitchell, K Whitman, TJ Zapor, MJ Zorich, S Witkop, C Jenkins, P Mora, P Droller, D Turner, S Dunn, L Williams, P Richards, C Ewing, G Chapman, K Corbitt, C Girimont, T Franka, R Recuenco, S Blanton, JD Feldman, KA AF Wallace, R. M. Stanek, D. Griese, S. Krulak, D. Vora, N. M. Pacha, L. Kan, V. Said, M. Williams, C. Burgess, T. H. Clausen, S. S. Austin, C. Gabel, J. Lehman, M. Finelli, L. N. Selvaggi, G. Joyce, P. Gordin, F. Benator, D. Bettano, A. Cersovsky, S. Blackmore, C. Jones, S. V. Buchanan, B. D. Fernandez, A. I. Dinelli, D. Agnes, K. Clark, A. Gill, J. Irmler, M. Blythe, D. Mitchell, K. Whitman, T. J. Zapor, M. J. Zorich, S. Witkop, C. Jenkins, P. Mora, P. Droller, D. Turner, S. Dunn, L. Williams, P. Richards, C. Ewing, G. Chapman, K. Corbitt, C. Girimont, T. Franka, R. Recuenco, S. Blanton, J. D. Feldman, K. A. TI A Large-scale, Rapid Public Health Response to Rabies in an Organ Recipient and the Previously Undiagnosed Organ Donor SO ZOONOSES AND PUBLIC HEALTH LA English DT Article ID POSTEXPOSURE PROPHYLAXIS; CARE-WORKERS; TRANSPLANT RECIPIENTS; UNITED-STATES; TRANSMISSION; PREVENTION; VIRUS; RISK AB This article describes and contrasts the public health response to two human rabies cases: one organ recipient diagnosed within days of symptom onset and the transplant donor who was diagnosed 18months post-symptom onset. In response to an organ-transplant-related rabies case diagnosed in 2013, organ donor and recipient investigations were conducted by multiple public health agencies. Persons with potential exposure to infectious patient materials were assessed for rabies virus exposure. An exposure investigation was conducted to determine the source of the organ donor's infection. Over 100 persons from more than 20 agencies spent over 2700h conducting contact investigations in healthcare, military and community settings. The 564 persons assessed include 417 healthcare workers [5.8% recommended for post-exposure prophylaxis (PEP)], 96 community contacts (15.6% recommended for PEP), 30 autopsy personnel (50% recommended for PEP), and 21 other persons (4.8% recommended for PEP). Donor contacts represented 188 assessed with 20.2% recommended for PEP, compared with 5.6% of 306 recipient contacts recommended for PEP. Human rabies cases result in substantial use of public health and medical resources, especially when diagnosis is delayed. Although rare, clinicians should consider rabies in cases of encephalitis of unexplained aetiology, particularly for cases that may result in organ donation. C1 [Wallace, R. M.; Vora, N. M.; Franka, R.; Recuenco, S.; Blanton, J. D.] Ctr Dis Control & Prevent, Poxvirus & Rabies Branch, DHCPP, Atlanta, GA 30333 USA. [Wallace, R. M.; Griese, S.; Vora, N. M.; Said, M.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Stanek, D.; Blackmore, C.] Florida Dept Hlth, Tallahassee, FL USA. [Griese, S.; Williams, C.] North Carolina Dept Hlth, Raleigh, NC USA. [Krulak, D.; Jones, S. V.; Buchanan, B. D.; Fernandez, A. I.; Dinelli, D.] Naval Hosp Pensacola, Pensacola, FL USA. [Pacha, L.; Cersovsky, S.] US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA. [Kan, V.; Joyce, P.; Gordin, F.; Benator, D.; Agnes, K.; Clark, A.; Gill, J.; Irmler, M.] Washington DC Vet Affairs Med Ctr, Washington, DC USA. [Kan, V.; Gordin, F.; Benator, D.] George Washington Univ, Washington, DC USA. [Said, M.; Blythe, D.; Mitchell, K.; Feldman, K. A.] Maryland Dept Hlth & Mental Hyg, Baltimore, MD USA. [Burgess, T. H.; Clausen, S. S.; Whitman, T. J.; Zapor, M. J.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. [Austin, C.] Illinois Dept Publ Hlth, Springfield, IL 62761 USA. [Gabel, J.] Georgia Dept Hlth, Atlanta, GA USA. [Lehman, M.; Bettano, A.; Zorich, S.] US Air Force Sch Aerosp Med, Dayton, OH USA. [Finelli, L. N.] Off Armed Forces Med Examiner, Dover, DE USA. [Selvaggi, G.; Mora, P.; Droller, D.] Broward Cty Hosp, Broward, FL USA. [Witkop, C.] Air Force Med Support Agcy, Dayton, OH USA. [Jenkins, P.] Florida Dept Hlth Broward Cty, Ft Lauderdale, FL USA. [Turner, S.; Dunn, L.; Williams, P.; Richards, C.] Florida Dept Hlth Escambia Cty, Pensacola, FL USA. [Ewing, G.] Sacred Heart Hosp, Pensacola, FL USA. [Chapman, K.] Okaloosa Cty Hlth Dept, Ft Walton Beach, FL USA. [Corbitt, C.] LifeQuest, Pensacola, FL USA. [Girimont, T.] Shands Transplant Ctr, Shands Transplant Lab, Gainesville, FL USA. RP Wallace, RM (reprint author), Ctr Dis Control & Prevent, Poxvirus & Rabies Branch, DHCPP, 1600 Clifton Rd,Mailstop G-33, Atlanta, GA 30333 USA. EM EUK5@cdc.gov OI Recuenco-Cabrera, Sergio/0000-0002-8446-7411 NR 32 TC 3 Z9 3 U1 0 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1863-1959 EI 1863-2378 J9 ZOONOSES PUBLIC HLTH JI Zoonoses Public Health PD DEC PY 2014 VL 61 IS 8 BP 560 EP 570 DI 10.1111/zph.12105 PG 11 WC Public, Environmental & Occupational Health; Infectious Diseases; Veterinary Sciences SC Public, Environmental & Occupational Health; Infectious Diseases; Veterinary Sciences GA AU0LI UT WOS:000345313800005 PM 24673934 ER PT J AU Margolis, LM Murphy, NE Martini, S Spitz, MG Thrane, I McGraw, SM Blatny, JM Castellani, JW Rood, JC Young, AJ Montain, SJ Gundersen, Y Pasiakos, SM AF Margolis, Lee M. Murphy, Nancy E. Martini, Svein Spitz, Marissa G. Thrane, Ingjerd McGraw, Susan M. Blatny, Janet-Martha Castellani, John W. Rood, Jennifer C. Young, Andrew J. Montain, Scott J. Gundersen, Yngvar Pasiakos, Stefan M. TI Effects of winter military training on energy balance, whole-body protein balance, muscle damage, soreness, and physical performance SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM LA English DT Article DE nitrogen; dietary protein; recommended dietary allowance; stress ID DOUBLY LABELED WATER; EXERCISE; TURNOVER; EXPENDITURE; VALIDATION; METABOLISM; PERSONNEL; NITROGEN; LEUCINE; DIETS AB Physiological consequences of winter military operations are not well described. This study examined Norwegian soldiers (n = 21 males) participating in a physically demanding winter training program to evaluate whether short-term military training alters energy and whole-body protein balance, muscle damage, soreness, and performance. Energy expenditure ((D2O)-O-18) and intake were measured daily, and postabsorptive whole-body protein turnover ([N-15]-glycine), muscle damage, soreness, and performance (vertical jump) were assessed at baseline, following a 4-day, military task training phase (MTT) and after a 3-day, 54-km ski march (SKI). Energy intake (kcal.day(-1)) increased (P < 0.01) from (mean +/- SD (95% confidence interval)) 3098 +/- 236 (2985, 3212) during MTT to 3461 +/- 586 (3178, 3743) during SKI, while protein (g.kg(-1).day(-1)) intake remained constant (MTT, 1.59 +/- 0.33 (1.51, 1.66); and SKI, 1.71 +/- 0.55 (1.58, 1.85)). Energy expenditure increased (P < 0.05) during SKI (6851 +/- 562 (6580, 7122)) compared with MTT (5480 +/- 389 (5293, 5668)) and exceeded energy intake. Protein flux, synthesis, and breakdown were all increased (P < 0.05) 24%, 18%, and 27%, respectively, during SKI compared with baseline and MTT. Whole-body protein balance was lower (P < 0.05) during SKI (-1.41 +/- 1.11 (-1.98, -0.84) g.kg(-1).10 h) than MTT and baseline. Muscle damage and soreness increased and performance decreased progressively (P < 0.05). The physiological consequences observed during short-term winter military training provide the basis for future studies to evaluate nutritional strategies that attenuate protein loss and sustain performance during severe energy deficits. C1 [Margolis, Lee M.; Murphy, Nancy E.; McGraw, Susan M.; Young, Andrew J.; Montain, Scott J.; Pasiakos, Stefan M.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. [Martini, Svein; Thrane, Ingjerd; Blatny, Janet-Martha; Gundersen, Yngvar] Norwegian Def Res Estab, N-2007 Kjeller, Norway. [Spitz, Marissa G.; Castellani, John W.] US Army Res Inst Environm Med, Thermal Mt & Med Div, Natick, MA 01760 USA. [Rood, Jennifer C.] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA. RP Pasiakos, SM (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM stefan.m.pasiakos.civ@mail.mil RI Pasiakos, Stefan/E-6295-2014; OI Pasiakos, Stefan/0000-0002-5378-5820; , Lee/0000-0002-0652-1304 FU US Army Medical Research and Material Command; Norwegian Defence Research Establishment [W81XWH-12-0279] FX The authors thank the soldiers that participated in this research experiment, the command, and training staff at the Garrison in Sor-Varanger (Kirkenes, Norway) for their support of this study. The investigators adhered to the policies for protection of human subjects as prescribed in Army Regulation 70-25, and the research was conducted in adherence with the provisions of 32 CFR part 219. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Army or the Department of Defense. Any citations of commercial organizations and trade names in this report do not constitute an official Department of the Army endorsement of approval of the products or services of these organizations. This work was supported by the US Army Medical Research and Material Command and the Norwegian Defence Research Establishment, under agreement no. W81XWH-12-0279. NR 33 TC 7 Z9 7 U1 1 U2 3 PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS PI OTTAWA PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA SN 1715-5312 EI 1715-5320 J9 APPL PHYSIOL NUTR ME JI Appl. Physiol. Nutr. Metab. PD DEC PY 2014 VL 39 IS 12 BP 1395 EP 1401 DI 10.1139/apnm-2014-0212 PG 7 WC Nutrition & Dietetics; Physiology; Sport Sciences SC Nutrition & Dietetics; Physiology; Sport Sciences GA AS9FJ UT WOS:000344548200011 PM 25386980 ER PT J AU Doty, TJ Japee, S Ingvar, M Ungerleider, LG AF Doty, Tracy J. Japee, Shruti Ingvar, Martin Ungerleider, Leslie G. TI Intersubject variability in fearful face processing: the link between behavior and neural activation SO COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE LA English DT Article DE Emotion; Fearful faces; Ventromedial prefrontal cortex; Subgenual cingulate cortex; Striatum; Affective value ID VENTROMEDIAL PREFRONTAL CORTEX; EMOTIONAL FACIAL EXPRESSIONS; EXPERIMENTALLY INDUCED ANXIETY; HUMAN AMYGDALA; FUNCTIONAL CONNECTIVITY; INDIVIDUAL-DIFFERENCES; PREDICTION ERRORS; VISUAL AWARENESS; ATTENTIONAL BIAS; SKIN-CONDUCTANCE AB Stimuli that signal threat show considerable variability in the extents to which they enhance behavior, even among healthy individuals. However, the neural underpinning of this behavioral variability is not well understood. By manipulating expectation of threat in an fMRI study of fearful versus neutral face categorization, we uncovered a network of areas underlying variability in threat processing in healthy adults. We explicitly altered expectations by presenting face images at three different expectation levels: 80 %, 50 %, and 20 %. Subjects were instructed to report as quickly and accurately as possible whether the face was fearful (signaled threat) or not. An uninformative cue preceded each face by 4 s. By taking the difference between reaction times (RTs) to fearful and neutral faces, we quantified an overall fear RT bias (i.e., faster to fearful than to neutral faces) for each subject. This bias correlated positively with late-trial fMRI activation (8 s after the face) during unexpected-fearful-face trials in bilateral ventromedial prefrontal cortex, the left subgenual cingulate cortex, and the right caudate nucleus, and correlated negatively with early-trial fMRI activation (4 s after the cue) during expected-neutral-face trials in bilateral dorsal striatum and the right ventral striatum. These results demonstrate that the variability in threat processing among healthy adults is reflected not only in behavior, but also in the magnitude of activation in medial prefrontal and striatal regions that appear to encode affective value. C1 [Doty, Tracy J.; Japee, Shruti; Ungerleider, Leslie G.] NIMH, Lab Brain & Cognit, Bethesda, MD 20892 USA. [Doty, Tracy J.; Ingvar, Martin] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden. [Doty, Tracy J.] US Army Res Lab, Translat Neurosci Branch, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Doty, TJ (reprint author), US Army Res Lab, Translat Neurosci Branch, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. EM tracy.doty@alumni.duke.edu OI Doty, Tracy/0000-0001-9921-2457; Ingvar, Martin/0000-0002-9041-5714 FU Intramural NIH HHS [ZIA MH002035-33] NR 68 TC 6 Z9 6 U1 5 U2 16 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1530-7026 EI 1531-135X J9 COGN AFFECT BEHAV NE JI Cogn. Affect. Behav. Neurosci. PD DEC PY 2014 VL 14 IS 4 BP 1438 EP 1453 DI 10.3758/s13415-014-0290-y PG 16 WC Behavioral Sciences; Neurosciences SC Behavioral Sciences; Neurosciences & Neurology GA AT0TP UT WOS:000344648000020 PM 24841078 ER PT J AU Cap, A Hunt, B AF Cap, Andrew Hunt, Beverley TI Acute traumatic coagulopathy SO CURRENT OPINION IN CRITICAL CARE LA English DT Review DE acute traumatic coagulopathy; endothelial activation; fibrinolysis; hemostatic resuscitation; hypoperfusion; microparticles; platelet dysfunction; tranexamic acid; viscoelastic coagulation monitoring ID ACTIVATED PROTEIN-C; DISSEMINATED INTRAVASCULAR COAGULATION; LIFE-THREATENING HEMORRHAGE; FRESH WHOLE-BLOOD; 1ST 24 HOURS; MASSIVE TRANSFUSION; TRANEXAMIC ACID; HEMOSTATIC RESUSCITATION; SEVERE INJURY; MAJOR TRAUMA AB Purpose of review Mortality from trauma remains a global public health challenge, with most preventable deaths due to bleeding. The recognition of acute traumatic coagulopathy as a distinct clinical entity characterized by early coagulation dysfunction, arising prior to medical intervention, has revolutionized trauma management over the last decade. The aim of this article is to review our current understanding of acute traumatic coagulopathy. Recent findings We focus on recent advances in the mechanistic understanding of acute traumatic coagulopathy, particularly the changes in coagulation factors, physiological anticoagulants, endothelial activation, fibrinolysis and platelet dysfunction. Evolving diagnostic and therapeutic approaches are discussed, including viscoelastic coagulation monitoring and the role of tranexamic acid and blood products. Summary Emphasis is now placed on early prevention, diagnosis, and aggressive initial treatment of coagulopathy and fibrinolysis with haemostatic blood products and tranexamic acid in addition to red cell units in order to reduce bleeding and improve clinical outcomes. C1 [Cap, Andrew] Uniformed Serv Univ Hlth Sci, US Army, Blood Res Program, Inst Surg Res,JBSA FT Sam Houston, San Antonio, TX USA. [Hunt, Beverley] St Thomas Hosp, Dept Haematol, London SE1 7EH, England. [Hunt, Beverley] Dept Pathol, London SE1 7EH, England. [Hunt, Beverley] Lupus Guys & St Thomas NHS Fdn Trust, London SE1 7EH, England. RP Hunt, B (reprint author), St Thomas Hosp, Dept Haematol, Westminster Bridge Rd, London SE1 7EH, England. EM Beverley.Hunt@gstt.nhs.uk NR 95 TC 8 Z9 9 U1 0 U2 12 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1070-5295 EI 1531-7072 J9 CURR OPIN CRIT CARE JI Curr. Opin. Crit. Care PD DEC PY 2014 VL 20 IS 6 BP 638 EP 645 DI 10.1097/MCC.0000000000000158 PG 8 WC Critical Care Medicine SC General & Internal Medicine GA AS8XS UT WOS:000344529000009 PM 25340382 ER PT J AU Sousa, JC Milner, E Carroll, D McCalmont, W Gardner, S Moon, J Johnson, JD Lee, P Auschwitz, J Roncal, N Caridha, D Tungteung, A Zeng, Q Reyes, S Smith, B Li, QG Kozar, MP Melendez, V Dow, G AF Sousa, Jason C. Milner, Erin Carroll, Dustin McCalmont, William Gardner, Sean Moon, Jay Johnson, Jacob D. Lee, Patricia Auschwitz, Jennifer Roncal, Norma Caridha, Diana Tungteung, Anchalee Zeng, Qiang Reyes, Sean Smith, Bryan Li, Qigui Kozar, Michael P. Melendez, Victor Dow, Geoffrey TI The use of a prodrug approach to minimize potential CNS exposure of next generation quinoline methanols while maintaining efficacy in in vivo animal models SO EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS LA English DT Article DE Malaria; Mefloquine; Quinoline methanol; Blood-brain barrier; Central nervous system; Prodrug ID PLASMODIUM-FALCIPARUM; ANTIMALARIAL-DRUGS; INVITRO; GROWTH AB The use of mefloquine (MQ) for antimalarial treatment and prophylaxis has diminished largely in response to concerns about its neurologic side effects. An analog campaign designed to maintain the efficacy of MQ while minimizing blood-brain barrier (BBB) penetration has resulted in the synthesis of a prodrug with comparable-to-superior in vivo efficacy versus mefloquine in a P. berghei mouse model while exhibiting a sixfold reduction in CNS drug levels. The prodrug, WR319670, performed poorly compared to MQ in in vitro efficacy assays, but had promising in vitro permeability in an MDCK-MDR1 cell line BBB permeability screen. Its metabolite, WR308245, exhibited high predicted BBB penetration with excellent in vitro efficacy. Both WR319670 and WR308245 cured 5/5 animals in separate in vivo efficacy studies. The in vivo efficacy of WR319670 was thought to be due to the formation of a more active metabolite, specifically WR308245. This was supported by pharmacokinetics studies in non-infected mice, which showed that both IV and oral administration of WR319670 produced essentially identical levels of WR319670 and WR308245 in both plasma and brain samples at all time points. In these studies, the levels of WR308245 in the brain were 1/4 and 1/6 that of MQ in similar IV and oral studies, respectively. These data show that the use of WR319670 as an antimalarial prodrug was able to maintain efficacy in in vivo efficacy screens, while significantly lowering overall penetration of drug and metabolites across the BBB. C1 [Sousa, Jason C.; Milner, Erin; Carroll, Dustin; McCalmont, William; Gardner, Sean; Moon, Jay; Johnson, Jacob D.; Lee, Patricia; Auschwitz, Jennifer; Roncal, Norma; Caridha, Diana; Zeng, Qiang; Reyes, Sean; Smith, Bryan; Li, Qigui; Kozar, Michael P.; Melendez, Victor; Dow, Geoffrey] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Tungteung, Anchalee] US Army Med Component, Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Dow, Geoffrey] US Army Med Mat Dev Act, Frederick, MD 21702 USA. RP Sousa, JC (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. EM Jason.sousa@amedd.army.mil; geoffrey.dow@us.army.mil NR 14 TC 1 Z9 1 U1 2 U2 11 PU SPRINGER FRANCE PI PARIS PA 22 RUE DE PALESTRO, PARIS, 75002, FRANCE SN 0378-7966 EI 2107-0180 J9 EUR J DRUG METAB PH JI Eur. J. Drug Metabol. Pharmacokinet. PD DEC PY 2014 VL 39 IS 4 BP 231 EP 236 DI 10.1007/s13318-013-0162-9 PG 6 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA AT2DJ UT WOS:000344741300001 PM 24705994 ER PT J AU O'Connell, RJ Kim, JH Excler, JL AF O'Connell, Robert J. Kim, Jerome H. Excler, Jean-Louis TI The HIV-1 gp120 V1V2 loop: structure, function and importance for vaccine development SO EXPERT REVIEW OF VACCINES LA English DT Review DE efficacy; gp120; HIV vaccine; neutralizing antibodies; nonneutralizing antibodies; RV144; V1V2 loop ID IMMUNODEFICIENCY-VIRUS TYPE-1; RECOMBINANT GLYCOPROTEIN-120 VACCINE; BROADLY NEUTRALIZING ANTIBODIES; T-CELL RESPONSES; EFFICACY TRIAL; ENVELOPE GLYCOPROTEIN; HIV-1-INFECTED INDIVIDUALS; MONOCLONAL-ANTIBODIES; RHESUS-MONKEYS; GLYCOSYLATION SITES AB Although the second variable loop (V2) of the HIV-1 gp120 envelope glycoprotein shows substantial sequence diversity between strains, its functional importance imposes critical conservation of structure, and within particular microdomains, of sequence. V2 influences HIV-1 viral entry by contributing to trimer stabilization and co-receptor binding. It is one of 4 key domains targeted by the broadly neutralizing antibodies that arise during HIV-1 infection. HIV-1 uses V1V2 sequence variation and glycosylation to escape neutralizing antibody. In the Thai Phase III HIV-1 vaccine trial, RV144, vaccine-induced IgG against V1V2 inversely correlated with the risk of HIV-1 acquisition, and HIV-1 strains infecting RV144 vaccine recipients differed from those infecting placebo recipients in the V2 domain. Similarly, non-human primate challenge studies demonstrated an inverse correlation between vaccine-induced anti-V2 responses and simian immunodeficiency virus acquisition. We hypothesize that increased magnitude, frequency and duration of vaccine-induced anti-V2 antibody responses should improve efficacy afforded by pox-protein prime-boost HIV vaccine strategies. C1 [O'Connell, Robert J.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Kim, Jerome H.; Excler, Jean-Louis] US Mil HIV Res Program MHRP, Bethesda, MD 20817 USA. [Excler, Jean-Louis] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD 20817 USA. RP O'Connell, RJ (reprint author), Armed Forces Res Inst Med Sci, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM robert.oconnell@afrims.org FU US Army Medical Research and Materiel Command (USAMRMC) [DAMD17-98-2-7007]; Henry M. Jackson Foundation for the Advancement of Military Medicine FX The authors received funding from the US Army Medical Research and Materiel Command (USAMRMC), and its Cooperative Agreement (DAMD17-98-2-7007) with the Henry M. Jackson Foundation for the Advancement of Military Medicine. The views expressed in this manuscript are those of the authors and do not reflect the official policy or position of the Department of the Army, Department of Defense or the US Government. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. NR 108 TC 3 Z9 3 U1 3 U2 23 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1476-0584 EI 1744-8395 J9 EXPERT REV VACCINES JI Expert Rev. Vaccines PD DEC PY 2014 VL 13 IS 12 BP 1489 EP 1500 DI 10.1586/14760584.2014.951335 PG 12 WC Immunology SC Immunology GA AT4TL UT WOS:000344935000008 PM 25163695 ER PT J AU Reid, MW Miller, KJ Lange, RT Cooper, DB Tate, DF Bailie, J Brickell, TA French, LM Asmussen, S Kennedy, JE AF Reid, Matthew W. Miller, Kelly J. Lange, Rael T. Cooper, Douglas B. Tate, David F. Bailie, Jason Brickell, Tracey A. French, Louis M. Asmussen, Sarah Kennedy, Jan E. TI A Multisite Study of the Relationships between Blast Exposures and Symptom Reporting in a Post-Deployment Active Duty Military Population with Mild Traumatic Brain Injury SO JOURNAL OF NEUROTRAUMA LA English DT Article DE post-concussion; blast; post-traumatic stress; neurobehavioral symptom inventory; mild traumatic brain injury ID POSTTRAUMATIC-STRESS-DISORDER; OIF/OEF SERVICE MEMBERS; POSTCONCUSSIVE SYMPTOMS; IRAQI FREEDOM; HEALTH; VETERANS; TBI; ASSOCIATIONS; PTSD AB Explosive devices have been the most frequent cause of traumatic brain injury (TBI) among deployed contemporary U.S. service members. The purpose of this study was to examine the influence of previous cumulative blast exposures (that did or did not result in TBI) on later post-concussion and post-traumatic symptom reporting after sustaining a mild TBI (MTBI). Participants were 573 service members who sustained MTBI divided into four groups by number of blast exposures (1, 2, 3, and 4-10) and a nonblast control group. Post-concussion symptoms were measured using the Neurobehavioral Symptom Inventory (NSI) and post-traumatic stress disorder (PTSD) symptoms using the Post-traumatic Checklist-Civilian version (PCL-C). Results show groups significantly differed on total NSI scores (p<0.001), where symptom endorsement increased as number of reported blast exposures increased. Total NSI scores were significantly higher for the 3- and 4-10 blast groups compared with the 1- and 2-blast groups with effect sizes ranging from small to moderate (d=0.31 to 0.63). After controlling for PTSD symptoms using the PCL-C total score, NSI total score differences remained between the 4-10-blast group and the 1- and 2-blast groups, but were less pronounced (d=0.35 and d=0.24, respectively). Analyses of NSI subscale scores using PCL-C scores as a covariate revealed significant between-blast group differences on cognitive, sensory, and somatic, but not affective symptoms. Regression analyses revealed that cumulative blast exposures accounted for a small but significant amount of the variance in total NSI scores (4.8%; p=0.009) and total PCL-C scores (2.3%; p<0.001). Among service members exposed to blast, post-concussion symptom reporting increased as a function of cumulative blast exposures. Future research will need to determine the relationship between cumulative blast exposures, symptom reporting, and neuropathological changes. C1 [Reid, Matthew W.; Miller, Kelly J.; Lange, Rael T.; Cooper, Douglas B.; Tate, David F.; Bailie, Jason; Brickell, Tracey A.; French, Louis M.; Asmussen, Sarah; Kennedy, Jan E.] Def & Vet Brain Injury Ctr, Silver Spring, MD USA. [Reid, Matthew W.; Cooper, Douglas B.; Tate, David F.; Kennedy, Jan E.] San Antonio Mil Med Ctr, San Antonio, TX USA. [Miller, Kelly J.; Lange, Rael T.; Brickell, Tracey A.; French, Louis M.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. [Brickell, Tracey A.; French, Louis M.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Lange, Rael T.; Brickell, Tracey A.; French, Louis M.] Ctr Neurosci & Regenerat Med, Bethesda, MD USA. [Lange, Rael T.] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada. [Bailie, Jason; Asmussen, Sarah] Naval Med Ctr San Diego, San Diego, CA USA. [Asmussen, Sarah] Marine Corps Base Camp Pendleton, Camp Pendleton, CA USA. RP Reid, MW (reprint author), Brooke Army Med Ctr, MCHE MDU DVBIC, 3551 Roger Brooke Dr, Jbsa Ft Sam Houston, TX 78234 USA. EM matthew.w.reid2.ctr@mail.mil RI Tate, David/I-3963-2013 FU NINDS NIH HHS [L30 NS063444] NR 26 TC 14 Z9 14 U1 1 U2 3 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD DEC 1 PY 2014 VL 31 IS 23 BP 1899 EP 1906 DI 10.1089/neu.2014.3455 PG 8 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA AT6US UT WOS:000345075500001 PM 25036531 ER PT J AU Kogot, JM Pennington, JM Sarkes, DA Kingery, DA Pellegrino, PM Stratis-Cullum, DN AF Kogot, Joshua M. Pennington, Joseph M. Sarkes, Deborah A. Kingery, David A. Pellegrino, Paul M. Stratis-Cullum, Dimitra N. TI Screening and characterization of anti-SEB peptides using a bacterial display library and microfluidic magnetic sorting SO JOURNAL OF MOLECULAR RECOGNITION LA English DT Article DE SEB; peptide; bacterial display; microfluidic; peptide ELISA; peptide display; biothreat ID STAPHYLOCOCCAL-ENTEROTOXIN-B; FLOW-CYTOMETRY; AFFINITY; PROTEINS; LIGANDS AB Bacterial peptide display libraries enable the rapid and efficient selection of peptides that have high affinity and selectivity toward their targets. Using a 15-mer random library on the outer surface of Escherichia coli (E.coli), high-affinity peptides were selected against a staphylococcal enterotoxin B (SEB) protein after four rounds of biopanning. On-cell screening analysis of affinity and specificity were measured by flow cytometry and directly compared to the synthetic peptide, off-cell, using peptide-ELISA. DNA sequencing of the positive clones after four rounds of microfluidic magnetic sorting (MMS) revealed a common consensus sequence of (S/T)CH(Y/F)W for the SEB-binding peptides R338, R418, and R445. The consensus sequence in these bacterial display peptides has similar amino acid characteristics with SEB peptide sequences isolated from phage display. The K-d measured by peptide-ELISA off-cell was 2.4nM for R418 and 3.0nM for R445. The bacterial peptide display methodology using the semiautomated MMS resulted in the discovery of selective peptides with affinity for a food safety and defense threat. Published 2014. This article is a U.S. Government work and is in the public domain in the USA. Journal of Molecular Recognition published by John Wiley & Sons, Ltd. C1 [Kogot, Joshua M.; Pennington, Joseph M.; Sarkes, Deborah A.; Kingery, David A.; Pellegrino, Paul M.; Stratis-Cullum, Dimitra N.] US Army Res Lab, Adelphi, MD 20783 USA. RP Stratis-Cullum, DN (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM dimitra.n.stratis-cullum.civ@mail.mil NR 29 TC 4 Z9 4 U1 5 U2 46 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0952-3499 EI 1099-1352 J9 J MOL RECOGNIT JI J. Mol. Recognit. PD DEC PY 2014 VL 27 IS 12 BP 739 EP 745 DI 10.1002/jmr.2400 PG 7 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA AS0WU UT WOS:000343997400007 PM 25319622 ER PT J AU Jenks, C AF Jenks, C. TI Moral touchstone, not general deterrence: The role of international criminal justice in fostering compliance with international humanitarian law SO INTERNATIONAL REVIEW OF THE RED CROSS LA English DT Article DE deterrence; compliance; international criminal justice; international humanitarian law; prevention C1 [Jenks, C.] SMU Dedman Sch Law, Law, Dallas, TX 75205 USA. [Jenks, C.] SMU Dedman Sch Law, Criminal Justice Clin, Dallas, TX USA. [Jenks, C.] SMU, Fac Law, Dallas, TX USA. [Jenks, C.] US Army, Washington, DC USA. [Jenks, C.] Armys Int Law Branch, Pentagon, VA USA. RP Jenks, C (reprint author), SMU Dedman Sch Law, Law, Dallas, TX 75205 USA. NR 52 TC 0 Z9 0 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 1816-3831 EI 1607-5889 J9 INT REV RED CROSS JI Int. Rev. Red Cross PD DEC PY 2014 VL 96 IS 895 BP 776 EP 794 PG 19 WC Law SC Government & Law GA V41PB UT WOS:000209557000007 ER PT J AU Davis, MT Mulvaney-Day, N Larson, MJ Hoover, R Mauch, D AF Davis, Margot T. Mulvaney-Day, Norah Larson, Mary Jo Hoover, Ronald Mauch, Danna TI Complementary and Alternative Medicine Among Veterans and Military Personnel A Synthesis of Population Surveys SO MEDICAL CARE LA English DT Article DE military veteran; complementary alternative medicine; population survey; psychological health conditions; PTSD; survey analysis AB Background: Recent reports reinforce the widespread interest in complementary and alternative medicine (CAM), not only among military personnel with combat-related disorders, but also among providers who are pressed to respond to patient demand for these therapies. However, an understanding of utilization of CAM therapies in this population is lacking. Objective: The goals of this study are to synthesize the content of self-report population surveys with information on use of CAM in military and veteran populations, assess gaps in knowledge, and suggest ways to address current limitations. Research Design: The research team conducted a literature review of population surveys to identify CAM definitions, whether military status was queried, the medical and psychological conditions queried, and each specific CAM question. Utilization estimates specific to military/veterans were summarized and limitations to knowledge was classified. Results: Seven surveys of CAM utilization were conducted with military/veteran groups. In addition, 7 household surveys queried military status, although there was no military/veteran subgroup analysis. Definition of CAM varied widely limiting cross-survey analysis. Among active duty and Reserve military, CAM use ranged between 37% and 46%. Survey estimates do not specify CAM use that is associated with a medical or behavioral health condition. Conclusions: Comparisons between surveys are hampered due to variation in methodologies. Too little is known about reasons for using CAM and conditions for which it is used. Additional information could be drawn from current surveys with additional subgroup analysis, and future surveys of CAM should include military status variable. C1 [Davis, Margot T.; Larson, Mary Jo] Brandeis Univ, Heller Sch Social Policy & Management, Inst Behav Hlth, 415 South St, Waltham, MA 02454 USA. [Mulvaney-Day, Norah; Mauch, Danna] Abt Associates Inc, Cambridge, MA USA. [Hoover, Ronald] US Army Med Res & Mat Command, Ft Detrick, MD USA. RP Davis, MT (reprint author), Brandeis Univ, Heller Sch Social Policy & Management, Inst Behav Hlth, 415 South St, Waltham, MA 02454 USA. EM margotd@brandeis.edu FU Institute of Behavioral Health, Heller School, Brandeis University FX The authors would like to acknowledge the support of Institute of Behavioral Health, Heller School, Brandeis University and additional research help from Lauren Hajjar. NR 43 TC 4 Z9 4 U1 4 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0025-7079 EI 1537-1948 J9 MED CARE JI Med. Care PD DEC PY 2014 VL 52 IS 12 SU 5 BP S83 EP S90 PG 8 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA V45TM UT WOS:000209838900014 PM 25397828 ER PT J AU Gerdes, J Holness, A Perez-Rosado, A Roberts, L Greisinger, A Barnett, E Kempny, J Lingam, D Yeh, CH Bruck, HA Gupta, SK AF Gerdes, John Holness, Alex Perez-Rosado, Ariel Roberts, Luke Greisinger, Adrian Barnett, Eli Kempny, Johannes Lingam, Deepak Yeh, Chen-Haur Bruck, Hugh A. Gupta, Satyandra K. TI Robo Raven: A Flapping-Wing Air Vehicle with Highly Compliant and Independently Controlled Wings SO SOFT ROBOTICS LA English DT Article ID MANEUVERING FLIGHT; AVIAN TAIL; AERODYNAMICS; MECHANISMS; EFFICIENCY; PIGEONS; DESIGN; BIRDS AB Many current bird-inspired flapping-wing air vehicles (FWAVs) achieve their flight characteristics through deformations associated with compliant wings during the flapping cycle. Most FWAVs use a single actuator to flap both wings. This couples and synchronizes motions of the wings, which only provides variable rate flapping at constant amplitude to control wing deformations. Independent wing control has the potential to provide a greater flight envelope through the ability to program wing motions to achieve a desired wing shape and associated aerodynamic forces. This approach requires the use of at least two actuators with position and velocity control that can be programmed to drive the wings independently. Integration of two actuators in a flying platform significantly increases the weight and hence makes it challenging to achieve flight. Based on our previous designs with synchronized wing flapping, we developed a new FWAV platform using programmable digital servo motors and a compatible highly compliant wing design that enables shape control of the wings during the flapping cycle. The wings and flapping characteristics can generate the highest possible lift near the maximum power operating point for the servos. The servos were integrated into a wing drive subsystem consisting of 3D printed and laser-etched/cut structural components to reduce part count and weight. A servo-driven tail was also used to augment the steering control and lift of the FWAV. The platform reported in this article, known as Robo Raven, was the first demonstration of a bird-inspired platform doing outdoor aerobatics using independently actuated and controlled wings. This platform successfully performed dives, flips, and buttonhook turns, demonstrating the capability of bioinspired aerobatic maneuvers afforded by the new design. C1 [Gerdes, John] US Army Res Lab, Aberdeen Proving Ground, MD USA. [Holness, Alex; Perez-Rosado, Ariel; Roberts, Luke; Greisinger, Adrian; Barnett, Eli; Kempny, Johannes; Lingam, Deepak; Yeh, Chen-Haur; Bruck, Hugh A.; Gupta, Satyandra K.] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. RP Gupta, SK (reprint author), Univ Maryland, Dept Mech Engn, 2181 Martin Hall, College Pk, MD 20742 USA. EM skgupta@umd.edu FU U.S. Army Research Laboratory Vehicle Technologies Directorate; Science, Mathematics, & Research for Transformation Scholarship; AFOSR [FA9550-12-1-0158] FX This work was sponsored in part by U.S. Army Research Laboratory Vehicle Technologies Directorate and the Science, Mathematics, & Research for Transformation Scholarship, administered by the American Society for Engineering Education and Naval Postgraduate School and AFOSR grant FA9550-12-1-0158. The support of Dr. Byung-Lip "Les'' Lee program manager, AFOSR is also greatly appreciated. NR 58 TC 19 Z9 19 U1 4 U2 16 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 2169-5172 EI 2169-5180 J9 SOFT ROBOT JI Soft Robot. PD DEC PY 2014 VL 1 IS 4 BP 275 EP 288 DI 10.1089/soro.2014.0019 PG 14 WC Robotics SC Robotics GA CV8WI UT WOS:000364568400008 ER PT J AU Gilbert, JA Ball, M Blainey, P Blaser, MJ Bohannan, BJ Bateman, A Bunge, J Dominguez-Bello, MG Epstein, S Fierer, N Gevers, D Grikscheit, T Hamdan, LJ Harvey, J Huttenhower, C Kirkup, B Kong, HH Lauber, C Lemon, KP Lynch, SV Martin, L Mello, C Palma, J Parker, R Petrosino, J Segre, JA Vosshall, L Yi, R Knight, R AF Gilbert, Jack A. Ball, Madeleine Blainey, Paul Blaser, Martin J. Bohannan, Brendan Jm Bateman, Ashley Bunge, John Dominguez-Bello, Maria Gloria Epstein, Slava Fierer, Noah Gevers, Dirk Grikscheit, Tracy Hamdan, Leila J. Harvey, James Huttenhower, Curtis Kirkup, Benjamin Kong, Heidi H. Lauber, Christian Lemon, Katherine P. Lynch, Susan V. Martin, Lance Mello, Charlene Palma, Joseph Parker, Roy Petrosino, Joseph Segre, Julia A. Vosshall, Leslie Yi, Rui Knight, Rob TI Meeting report for the 1st skin microbiota workshop, boulder, CO October 15-16 2012 SO STANDARDS IN GENOMIC SCIENCES LA English DT Article DE Skin microbiome; Army; Bioinformatics AB This report details the outcome of the 1st Skin Microbiota Workshop, Boulder, CO, held on October 15th-16th 2012. The workshop was arranged to bring Department of Defense personnel together with experts in microbial ecology, human skin physiology and anatomy, and computational techniques for interrogating the microbiome to define research frontiers at the intersection of these important areas. The workshop outlined a series of questions and created several working groups to address those questions, specifically to promote interdisciplinary activity and potential future collaboration. The US Army provided generous grant support and the meeting was organized and hosted by the University of Colorado at Boulder. A primary forward vision of the meeting was the importance of understanding skin microbial communities to improve the health and stealth of US Army warfighters. C1 [Gilbert, Jack A.] Argonne Natl Lab, 9700 S Cass Ave, Argonne, IL 60439 USA. [Gilbert, Jack A.] Univ Chicago, Dept Ecol & Evolut, Chicago, IL 60637 USA. [Ball, Madeleine] Harvard Med Sch, Dept Genet, Boston, MA 02115 USA. Broad Inst & MIT Dept Biol Engn, Cambridge, MA USA. [Blaser, Martin J.] NYU Langone Med Ctr, Dept Med, New York, NY USA. New York Harbor VA Med Ctr, New York, NY USA. [Bohannan, Brendan Jm; Bateman, Ashley] Univ Oregon, Inst Ecol & Evolut, Eugene, OR 97403 USA. [Bunge, John] Cornell Univ, Dept Stat Sci, Ithaca, NY USA. [Dominguez-Bello, Maria Gloria] NYU, Dept Med, New York, NY 10016 USA. [Dominguez-Bello, Maria Gloria] Univ Puerto Rico, Dept Biol, Mayaguez, PR USA. [Epstein, Slava] Northeastern Univ, Dept Biol, Boston, MA 02115 USA. [Fierer, Noah] Univ Colorado, Dept Ecol & Evolutionary Biol, Boulder, CO 80309 USA. [Fierer, Noah; Lauber, Christian] Univ Colorado, CIRES, Boulder, CO 80309 USA. [Gevers, Dirk] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA. [Grikscheit, Tracy] Childrens Hosp Los Angeles, Saban Res Inst, USC, Div Pediat Surg,Keck Sch Med, Los Angeles, CA 90027 USA. [Hamdan, Leila J.] George Mason Univ, Manassas, VA 20110 USA. [Harvey, James] US Army Res Off, Res Triangle Pk, NC USA. [Huttenhower, Curtis] Harvard Sch Publ Hlth, Dept Biostat, Boston, MA USA. [Kirkup, Benjamin] Walter Reed Army Inst Res, Dept Wound Infect, Silver Spring, MD USA. [Kirkup, Benjamin] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. [Kong, Heidi H.] NCI, NIH, Dermatol Branch, Ctr Canc Res, Bethesda, MD 20892 USA. [Lemon, Katherine P.] Forsyth Inst, Dept Microbiol, Cambridge, MA USA. [Lemon, Katherine P.] Boston Childrens Hosp, Div Infect Dis, Boston, MA USA. [Lynch, Susan V.] Univ Calif San Francisco, Dept Med, Div Gastroenterol, San Francisco, CA USA. [Martin, Lance] Stanford Univ, Sch Med, Dept Bioengn, Program Epithelial Biol, Stanford, CA 94305 USA. [Martin, Lance] Stanford Univ, Stanford, CA 94305 USA. [Mello, Charlene; Palma, Joseph] US Natick Soldier Ctr, Natick, MA USA. [Parker, Roy; Knight, Rob] Howard Hughes Med Inst, Boulder, CO USA. [Parker, Roy; Knight, Rob] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA. [Parker, Roy; Knight, Rob] Univ Colorado, BioFrontiers Inst, Boulder, CO 80309 USA. [Petrosino, Joseph] Baylor Coll Med, Dept Mol Virol & Microbiol, Alkek Ctr Metagen & Microbiome Res, Houston, TX 77030 USA. [Segre, Julia A.] NHGRI, NIH, Bethesda, MD 20892 USA. [Vosshall, Leslie] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10021 USA. [Yi, Rui] Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA. RP Gilbert, JA (reprint author), Argonne Natl Lab, 9700 S Cass Ave, Argonne, IL 60439 USA. EM gilbertjack@gmail.com OI Blainey, Paul/0000-0002-4889-8783; Kirkup, Benjamin/0000-0002-8722-6218; Kong, Heidi/0000-0003-4424-064X FU U.S. Army Research Laboratory; U.S. Army Research Office [W911NF-12-1-0513] FX This workshop was supported in part by the U.S. Army Research Laboratory and the U.S. Army Research Office under grant number W911NF-12-1-0513. We thank Wally Buchholtz, who is the program manager for this program, and Jerry Kennedy and Ulla Westermann for superb assistance on the logistics. NR 26 TC 0 Z9 1 U1 1 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1944-3277 J9 STAND GENOMIC SCI JI Stand. Genomic Sci. PD DEC PY 2014 VL 9 IS 1 AR 13 DI 10.1186/1944-3277-9-13 PG 7 WC Genetics & Heredity; Microbiology SC Genetics & Heredity; Microbiology GA V45LA UT WOS:000209816900013 ER PT J AU Westwood, J Burnett, M Spratt, D Ball, M Wilson, DJ Wellsteed, S Cleary, D Green, A Hutley, E Cichowska, A Hopkins, S Wilcox, M Kessel, A Zoubiane, G Bethke, L Crook, DW Walker, J Sutton, M Marsh, P Moore, G Wilson, P Holmes, A Hoffman, P Smith, C Oppenheim, B Parkhill, J Woodford, N Robotham, J Kidgell, C Anyim, M Gilkes, G Field, D Quick, J Pickering, T Kirkup, BC Gilbert, J AF Westwood, Jack Burnett, Matthew Spratt, David Ball, Michael Wilson, Daniel J. Wellsteed, Sally Cleary, David Green, Andy Hutley, Emma Cichowska, Anna Hopkins, Susan Wilcox, Mark Kessel, Anthony Zoubiane, Ghada Bethke, Lara Crook, Derrick W. Walker, Jimmy Sutton, Mark Marsh, Philip Moore, Ginny Wilson, Peter Holmes, Alison Hoffman, Peter Smith, Chris Oppenheim, Beryl Parkhill, Julian Woodford, Neil Robotham, Julie Kidgell, Claire Anyim, Martin Gilkes, Gabriella Field, Dawn Quick, Josh Pickering, Tony Kirkup, Benjamin C. Gilbert, Jack TI The hospital microbiome project: meeting report for the UK science and innovation network UK-USA workshop 'beating the superbugs: hospital microbiome studies for tackling antimicrobial resistance', October 14th 2013 SO STANDARDS IN GENOMIC SCIENCES LA English DT Article DE Antibiotic resistance; Nosocomial infections; Hospital microbiome; Superbugs AB The UK Science and Innovation Network UK-USA workshop 'Beating the Superbugs: Hospital Microbiome Studies for tackling Antimicrobial Resistance' was held on October 14th 2013 at the UK Department of Health, London. The workshop was designed to promote US-UK collaboration on hospital microbiome studies to add a new facet to our collective understanding of antimicrobial resistance. The assembled researchers debated the importance of the hospital microbial community in transmission of disease and as a reservoir for antimicrobial resistance genes, and discussed methodologies, hypotheses, and priorities. A number of complementary approaches were explored, although the importance of the built environment microbiome in disease transmission was not universally accepted. Current whole genome epidemiological methods are being pioneered in the UK and the benefits of moving to community analysis are not necessarily obvious to the pioneers; however, rapid progress in other areas of microbiology suggest to some researchers that hospital microbiome studies will be exceptionally fruitful even in the short term. Collaborative studies will recombine different strengths to tackle the international problems of antimicrobial resistance and hospital and healthcare associated infections. C1 [Westwood, Jack] British Consulate Gen, Chicago, IL 60611 USA. [Burnett, Matthew; Smith, Chris] Univ Cambridge, Dept Pathol, Cambridge, England. [Spratt, David] UCL Eastman Dent Inst, Dept Microbial Dis, London, England. [Ball, Michael] Biotechnol & Biol Sci Res Council, Swindon, Wilts, England. [Wilson, Daniel J.] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Med, Oxford, England. [Wellsteed, Sally] Richmond House, Dept Hlth, London, England. [Cleary, David] Def Sci & Technol Lab, Porton Down, Wilts, England. [Green, Andy; Hutley, Emma] Royal Ctr Def Med, Birmingham, W Midlands, England. [Cichowska, Anna; Hopkins, Susan; Kessel, Anthony] Publ Hlth England, London, England. [Wilcox, Mark] Univ Leeds, Leeds, W Yorkshire, England. [Wilcox, Mark] Leeds Teaching Hosp, Leeds, W Yorkshire, England. [Zoubiane, Ghada] MRC, London, England. [Bethke, Lara] Wellcome Trust Res Labs, London, England. [Crook, Derrick W.] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Med, Oxford OX3 9DU, England. [Walker, Jimmy; Moore, Ginny] Publ Hlth England, Biosafety Unit, Salisbury, Wilts, England. [Sutton, Mark; Marsh, Philip] HPA Microbiol Serv, Salisbury, Wilts, England. [Wilson, Peter] UCLH NHS Fdn Trust, Clin Microbiol & Virol, London, England. [Holmes, Alison] Imperial Coll, London, England. [Hoffman, Peter; Woodford, Neil] Publ Hlth England, Antimicrobial Resistance & Healthcare Associated, London, England. [Smith, Chris] Addenbrookes Hosp, Clin Microbiol & Publ Hlth Lab, Cambridge, England. [Oppenheim, Beryl] Queen Elizabeth Hosp, Birmingham, W Midlands, England. [Parkhill, Julian] Wellcome Trust Genome Campus, Wellcome Trust Sanger Inst, Cambridge, England. [Robotham, Julie] Publ Hlth England, Modeling & Econ Unit, Stat Modeling & Econ Dept, London, England. [Kidgell, Claire] Univ Southampton, Natl Inst Hlth Res, Evaluat Trials & Studies Coordinating Ctr NETSCC, Southampton, Hants, England. [Anyim, Martin] NIHR Invent Innovat Programme, London, England. [Gilkes, Gabriella] Human Micro Biome Project, Eden Project, St Austell PL24 2SG, Cornwall, England. [Field, Dawn] NERC Ctr Ecol & Hydrol, Oxford, England. [Quick, Josh] Univ Birmingham, Inst Microbiol & Infect, Birmingham, W Midlands, England. [Pickering, Tony] Univ South Manchester, North West Lung Res Ctr, Wythenshawe Hosp, Manchester, Lancs, England. [Kirkup, Benjamin C.] Walter Reed Army Inst Res, Dept Wound Infect, Bethesda, MD USA. [Gilbert, Jack] Univ Chicago, Dept Ecol & Evolut, 940 E 57Th St, Chicago, IL 60637 USA. [Gilbert, Jack] Argonne Natl Lab, Inst Genom & Syst Biol, Argonne, IL 60439 USA. RP Gilbert, J (reprint author), Univ Chicago, Dept Ecol & Evolut, 940 E 57Th St, Chicago, IL 60637 USA. EM gilbertjack@uchicago.edu OI Wilson, Daniel/0000-0002-0940-3311; Bethke, Lara/0000-0002-1316-4704; Hopkins, Susan/0000-0001-5179-5702 FU UK Science and Innovation Network; British Consulate-General Chicago; Foreign and Commonwealth Office; APSF; U.S. Dept. of Energy [DE-AC02-06CH11357] FX We acknowledge the UK Science and Innovation Network, British Consulate-General Chicago and Foreign and Commonwealth Office, as well as APSF for funding this workshop. This work was supported in part by the U.S. Dept. of Energy under Contract DE-AC02-06CH11357. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting true views of the Department of Army or the Department of Defense. NR 31 TC 1 Z9 2 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1944-3277 J9 STAND GENOMIC SCI JI Stand. Genomic Sci. PD DEC PY 2014 VL 9 IS 1 AR 12 DI 10.1186/1944-3277-9-12 PG 12 WC Genetics & Heredity; Microbiology SC Genetics & Heredity; Microbiology GA V45LA UT WOS:000209816900012 ER PT J AU Lichvar, RW AF Lichvar, Robert W. TI GENOMIC SIZE AND PLOIDY LEVEL PATTERNS OF INTERMOUNTAIN WEST LEPIDIUM DETERMINED USING FLOW CYTOMETRY SO WESTERN NORTH AMERICAN NATURALIST LA English DT Article ID NUCLEAR-DNA AMOUNTS; GENUS DRABA; BRASSICACEAE; CRUCIFERAE; EVOLUTION; PLANTS; ANGIOSPERMS; POLYPLOIDY; COMPLEX AB The taxonomic status of members of the genus Lepidium in the Intermountain West has been in flux for years. Species concepts and classification of these endemic species from the western United States center on the highly variable L. montanum complex. Until recently, classification treatments that use morphological features in this group have been adequate, but as new species are discovered and more locations reported, the limited number of morphological features available for classification and defining species concepts has led to more uncertainty about taxonomic rankings. As part of a molecular and morphological-based treatment of the group, flow cytometry was used to evaluate 58 collections of Lepidium from the Intermountain West. The ploidy level for 14 species and 11 varieties of Lepidium was surveyed to assess whether ploidy levels affected the interpretation of taxonomic rankings. Of the Lepidium taxa surveyed, 90% were tetraploid, and several were diploid and hexaploid. Tetraploid occurrences crossed all major species and varieties. No geographic distribution or habitat patterns were associated with ploidy level. C1 [Lichvar, Robert W.] US Army, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. RP Lichvar, RW (reprint author), US Army, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM robert.w.lichvar@usace.army.mil FU U.S. Army Corps of Engineers Engineering and Research Development Center/Cold Regions Research and Engineering Laboratory (ERDC/CRREL) Hanover, New Hampshire FX The quality and content of information reported here would not have been possible without the guidance, comments, and reviews provided by Diana Wolf and Gary Laursen of the University of Alaska and Ihsan Al-Shehbaz of the Missouri Botanical Garden. Funding for this effort was made possible by the U.S. Army Corps of Engineers Engineering and Research Development Center/Cold Regions Research and Engineering Laboratory (ERDC/CRREL), Hanover, New Hampshire. NR 44 TC 0 Z9 0 U1 1 U2 2 PU BRIGHAM YOUNG UNIV PI PROVO PA 290 LIFE SCIENCE MUSEUM, PROVO, UT 84602 USA SN 1527-0904 EI 1944-8341 J9 WEST N AM NATURALIST JI West. North Am. Naturalist PD DEC PY 2014 VL 74 IS 4 BP 369 EP 377 DI 10.3398/064.074.0402 PG 9 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA DE8NN UT WOS:000370892900001 ER PT J AU Migliaccio, CP AF Migliaccio, Christopher P. TI Resonance-induced condensate shedding for high-efficiency heat transfer SO INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER LA English DT Article DE Dropwise condensation; Resonance; Condensate shedding; Vibrating condenser ID DROPWISE CONDENSATION; SUPERHYDROPHOBIC SURFACES; SESSILE DROPS; VIBRATION; MOTION AB Condensers are heat rejection devices vital to industrial-scale systems including those found in the process and power industries. In a dropwise condensation system, the heat transferred to the condensing surface is related to the size distribution of attached drops. This study subjects a vertically-oriented condensing surface to mechanical vibrations ranging from 100 to 400 Hz, exciting the resonance modes of appropriately sized condensate drops. Resonating drops mobilize and shed from the surface at smaller size and with greater frequency than compared to a case without vibration, reducing the population of large, thermally inefficient drops on the surface. Excitation frequencies of 100 and 200 Hz yielded net improvement in estimated heat transfer rate in excess of 70% over the stationary case, suggesting that substantial reductions in fuel usage and footprint may be realized by applying this concept in condenser design. Published by Elsevier Ltd. C1 US Army Res Lab, Adelphi, MD 20783 USA. RP Migliaccio, CP (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM christopher.p.migliaccio.civ@mail.mil NR 41 TC 0 Z9 0 U1 6 U2 17 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0017-9310 EI 1879-2189 J9 INT J HEAT MASS TRAN JI Int. J. Heat Mass Transf. PD DEC PY 2014 VL 79 BP 720 EP 726 DI 10.1016/j.ijheatmasstransfer.2014.08.054 PG 7 WC Thermodynamics; Engineering, Mechanical; Mechanics SC Thermodynamics; Engineering; Mechanics GA AR7TE UT WOS:000343781900070 ER PT J AU Florio, LA AF Florio, L. A. TI Computation of fluid-particle interactions with high-speed compressible flows and multiple particles with deformation, plasticity, and collisions SO POWDER TECHNOLOGY LA English DT Article DE Fluid structure interaction; Computational fluid dynamics; Soft collision model; Particle flow; Plasticity; Deformation ID SIMULATION; MODEL; ASSEMBLIES; VISCOSITY; BEHAVIOR; SPHERES; NUMBER AB Two phase direct particle-high speed compressible gas flow simulation techniques developed by the author are extended to include the effects of particle deformation and plasticity with a focus on high speed impact of metallic steel particles moving in high speed air. The first part of the study involves the development of the necessary modeling techniques. Using the results of fluid independent finite element analyses, normal force functions were devised to simulate the effect of a collision of two 1.5 mm radius steel particles over a range of relative impact velocities from 12.5 to 200 m/s with an elastic and then an elastic perfectly plastic material model. Methods were introduced to model the deformation of the particles/objects. Use of the collision force model and the inclusion of deformation in a simulation of the collision between two particles in air replicated the appropriate short term post collision velocities of the corresponding finite element analysis. The parametric studies conducted during this model development demonstrated the importance of utilizing the proper material model in predicting the motion of the particles. A longer contact time and increasingly comparable post collision velocities for the two colliding particles develop with an elastic perfectly plastic based collision model, with the differences from the elastic based model results growing with collision velocity. The modeling techniques were then applied to analyze the motion of fourteen steel particles placed ahead of a gas driven piston in a flow channel 19.5 mm in width for three different piston driving pressures of 50, 75, and 100 MPa, implementing the elastic and then the elastic plastic based collision force models. The results clearly indicate that the incorporation of plasticity and particle deformation causes the particles to remain closer together both inside and outside of the flow channel. The modeling methods developed provide the ability to incorporate the plasticity/deformation effects of multiple interacting particles together with the local flow induced force to simulate the coupled gas flow and particle motion. The techniques developed offer a tool to capture more of the physical phenomena occurring in the two phase flow regime of interest, extending the capabilities to simulate the motion of gas-particles to a wider range of particle and flow velocities and providing information to assist in the understanding of particle motion and interaction characteristics. Published by Elsevier B.V. C1 US Army ARDEC, Technol Branch, Small Caliber Armaments Div, Picatinny Arsenal, NJ 07806 USA. RP Florio, LA (reprint author), US Army ARDEC, Technol Branch, Small Caliber Armaments Div, Picatinny Arsenal, NJ 07806 USA. EM laurie.a.florio.civ@mail.mil FU ARDEC In-House Laboratory Independent Research Project FX This work was funded by an ARDEC In-House Laboratory Independent Research Project. NR 29 TC 4 Z9 4 U1 1 U2 18 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0032-5910 EI 1873-328X J9 POWDER TECHNOL JI Powder Technol. PD DEC PY 2014 VL 268 BP 19 EP 37 DI 10.1016/j.powtec.2014.07.012 PG 19 WC Engineering, Chemical SC Engineering GA AR8WR UT WOS:000343852700003 ER PT J AU Grujicic, M Yavari, R Snipes, JS Ramaswami, S Yen, CF Cheeseman, BA AF Grujicic, M. Yavari, R. Snipes, J. S. Ramaswami, S. Yen, C. -F. Cheeseman, B. A. TI The effect of plain-weaving on the mechanical properties of warp and weft p-phenylene terephthalamide (PPTA) fibers/yarns SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID VINYL-ESTER-EPOXY; LEVEL ANALYSIS; ARAMID FIBERS; MODEL; PERFORMANCE; STRENGTH; POLYUREA; ARMOR; VERIFICATION; WAVE AB Coarse-grained molecular statics/dynamics methods are first used to investigate degradation in the PPTA fiber/yarn tensile strength, as a result of the prior compressive or tensile loading. PPTA fibers/yarns experience this type of loading in the course of a plain-weaving process, the process which is used in the fabrication of ballistic fabric and flexible armor. The more common all-atom molecular simulations were not used to assess strength degradation for two reasons: (a) the size of the associated computational domain rendering reasonable run-times would be too small and (b) modeling of the mechanical response of multi-fibril PPTA fibers could not be carried out (again due to the limited size of the computational domain). However, all-atom simulations were used to (a) define the coarse-grained particles (referred to as "beads") and (b) parameterize various components of the bead/bead force-field functions. In the second portion of the work, a simplified finite-element analysis of the plain-weaving process is carried out in order to assess the extent of tensile-strength degradation in warp and weft yarns during the weaving process. In this analysis, a new material model is used for the PPTA fibers/yarns. Specifically, PPTA is considered to be a linearly elastic, transversely isotropic material with degradable longitudinal-tensile strength and the longitudinal Young's modulus. Equations governing damage and strength/stiffness degradation in this material model are derived and parameterized using the coarse-grained simulation results. Lastly, the finite-element results are compared with their experimental counterparts, yielding a decent agreement. C1 [Grujicic, M.; Yavari, R.; Snipes, J. S.; Ramaswami, S.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. [Yen, C. -F.; Cheeseman, B. A.] Weap & Mat Res Directorate, Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM gmica@clemson.edu FU Army Research Office [W911NF-09-1-0513, W911NF-11-1-0207, W911NF-11-1-0518] FX The material presented in this paper is based on work supported by three Army Research Office sponsored grants entitled "Multi-length Scale Material Model Development for Armor-grade Composites" (Contract Number W911NF-09-1-0513), "Friction Stir Welding Behavior of Selected 2000- series and 5000-series Aluminum Alloys" (Contract Number W911NF-11-1-0207), and "Concept Validation and Optimization for a Vent-based Mine-blast Mitigation System" (Contract Number W911NF-11-1-0518). The authors are indebted to Dr. Ralph A. Anthenien, Jr., and Dr. Bryan J. Glaz of ARO for their continuing support and interest in the present work. NR 40 TC 6 Z9 6 U1 5 U2 44 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 EI 1573-4803 J9 J MATER SCI JI J. Mater. Sci. PD DEC PY 2014 VL 49 IS 24 BP 8272 EP 8293 DI 10.1007/s10853-014-8536-1 PG 22 WC Materials Science, Multidisciplinary SC Materials Science GA AQ0DO UT WOS:000342453000007 ER PT J AU Lian, H Du, P Li, YZ Liang, H AF Lian, Heng Du, Pang Li, YuanZhang Liang, Hua TI Partially linear structure identification in generalized additive models with NP-dimensionality SO COMPUTATIONAL STATISTICS & DATA ANALYSIS LA English DT Article DE Model structure identification; NP-dimensionality; Partially linear structure; Polynomial splines; Quasi-likelihood ID NONCONCAVE PENALIZED LIKELIHOOD; VARIABLE SELECTION; ORACLE PROPERTIES; REGRESSION; LASSO AB Separation of the linear and nonlinear components in additive models based on penalized likelihood has received attention recently. However, it remains unknown whether consistent separation is possible in generalized additive models, and how high dimensionality is allowed. In this article, we study the doubly SCAD-penalized approach for partial linear structure identification problems of non-polynomial (NP) dimensionality and demonstrate its oracle property. In particular, if the number of nonzero components is fixed, the dimensionality of the total number of components can be of order exp{n(d/(2d+1))} where d is the smoothness of the component functions. Under such dimensionality assumptions, we show that with probability approaching one, the proposed procedure can correctly identify the zero, linear, and nonlinear components in the model. We further establish the convergence rate of the estimator for the nonlinear component and the asymptotic normality of the estimator for the linear component. Performance of the proposed method is evaluated by simulation studies. The methods are demonstrated by analyzing a gene data set. (C) 2014 Elsevier B.V. All rights reserved. C1 [Lian, Heng] Nanyang Technol Univ, Sch Phys & Math Sci, Div Math Sci, Singapore 637371, Singapore. [Du, Pang] Virginia Tech, Dept Stat, Blacksburg, VA 24060 USA. [Li, YuanZhang] Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD USA. [Liang, Hua] George Washington Univ, Dept Stat, Washington, DC 20052 USA. RP Liang, H (reprint author), George Washington Univ, Dept Stat, Washington, DC 20052 USA. EM HengLian@ntu.edu.sg; pangdu@vt.edu; hliang@gwu.edu OI Lian, Heng/0000-0002-6008-6614 FU Singapore MOE Tier 1 Grant; NSF [DMS-1007126, DMS-1207444]; National Natural Science Foundation of China [11228103] FX The authors thank the AE and two reviewers for their insightful comments and suggestions that lead to significant improvement of the manuscript. Lian's research was supported by a Singapore MOE Tier 1 Grant. Du's research was supported by the NSF grant DMS-1007126. Liang's research was partially supported by NSF grant DMS-1207444 and by Award Number 11228103, given by the National Natural Science Foundation of China. The views expressed are those of the authors and should not be construed to represent the positions of the Department of the Army or Department of Defense. None of the authors have any associations, financial or otherwise, that may present a conflict of interest. NR 21 TC 1 Z9 1 U1 0 U2 10 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-9473 EI 1872-7352 J9 COMPUT STAT DATA AN JI Comput. Stat. Data Anal. PD DEC PY 2014 VL 80 BP 197 EP 208 DI 10.1016/j.csda.2014.06.021 PG 12 WC Computer Science, Interdisciplinary Applications; Statistics & Probability SC Computer Science; Mathematics GA AO4YC UT WOS:000341346300017 ER PT J AU Allen, JL Borodin, O Seo, DM Henderson, WA AF Allen, Joshua L. Borodin, Oleg Seo, Daniel M. Henderson, Wesley A. TI Combined quantum chemical/Raman spectroscopic analyses of Li+ cation solvation: Cyclic carbonate solvents-Ethylene carbonate and propylene carbonate SO JOURNAL OF POWER SOURCES LA English DT Article DE Battery; Electrolyte; Solvation number; Ethylene carbonate; Propylene carbonate; Raman spectroscopy ID NONAQUEOUS ELECTROLYTE-SOLUTIONS; LITHIUM PERCHLORATE; RAMAN-SPECTRA; CONCENTRATED-SOLUTIONS; TRANSPORT-PROPERTIES; GAMMA-BUTYROLACTONE; ION ASSOCIATION; LOCAL-STRUCTURE; LIQUID-PHASES; AB-INITIO AB Combined computational/Raman spectroscopic analyses of ethylene carbonate (EC) and propylene carbonate (PC) salvation interactions with lithium salts are reported. It is proposed that previously reported Raman analyses of (EC)(n)-LiX mixtures have utilized faulty assumptions. In the present studies, density functional theory (DFT) calculations have provided corrections in terms of both the scaling factors for the solvent's Raman band intensity variations and information about band overlap. By accounting for these factors, the salvation numbers obtained from two different EC solvent bands are in excellent agreement with one another. The same analysis for PC, however, was found to be quite challenging. Commercially available PC is a racemic mixture of (S)- and (R)-PC isomers. Based upon the quantum chemistry calculations, each of these solvent isomers may exist as multiple conformers due to a low energy barrier for ring inversion, making deconvolution of the Raman bands daunting and inherently prone to significant error. Thus, Raman spectroscopy is able to accurately determine the extent of the EC ... Li+ cation salvation interactions using the provided methodology, but a similar analysis of PC ... Li+ cation salvation results in a significant underestimation of the actual salvation numbers. (C) 2014 Elsevier B.V. All rights reserved. C1 [Allen, Joshua L.; Seo, Daniel M.; Henderson, Wesley A.] N Carolina State Univ, Ion Liquids & Electrolytes Energy Technol ILEET L, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA. [Allen, Joshua L.; Borodin, Oleg] US Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA. [Henderson, Wesley A.] Pacific NW Natl Lab, Energy & Environm Directorate, Electrochem Mat & Syst Grp, Richland, WA 99352 USA. RP Henderson, WA (reprint author), Pacific NW Natl Lab, Energy & Environm Directorate, Electrochem Mat & Syst Grp, Richland, WA 99352 USA. EM oleg.a.borodin.civ@mail.mil; Wesley.Henderson@pnnl.gov RI Borodin, Oleg/B-6855-2012 OI Borodin, Oleg/0000-0002-9428-5291 FU U.S. DOE BATT Program [DE-AC02-05-CH11231, DE-IA01-11EE003413]; U.S. DOE, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering [DE-SC0002169]; SMART Graduate Research Fellowship by the SMART Scholarship Program; American Society for Engineering Education (ASEE) FX This work was funded by the U.S. DOE BATT Program (contract number DE-AC02-05-CH11231) for the experimental work related to the pure solvents, the U.S. DOE, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering (contract number DE-SC0002169) for the experimental work related to the solvent-lithium salt electrolytes and the U.S. DOE BATT Program (contract number DE-IA01-11EE003413 through an Interagency Agreement between the U.S. DOE ABR program and the U.S. Army Research Laboratory (ARL)) for the computational work. J.L.A. is grateful for the award of a SMART Graduate Research Fellowship by the SMART Scholarship Program and the American Society for Engineering Education (ASEE). NR 37 TC 19 Z9 19 U1 6 U2 140 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 EI 1873-2755 J9 J POWER SOURCES JI J. Power Sources PD DEC 1 PY 2014 VL 267 BP 821 EP 830 DI 10.1016/j.jpowsour.2014.05.107 PG 10 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA AM1JI UT WOS:000339601800098 ER PT J AU Terrill, WA AF Terrill, W. Andrew TI The Battle for Syria: 1918-1920 SO MIDDLE EAST JOURNAL LA English DT Book Review C1 [Terrill, W. Andrew] US Army War Coll, Carlisle, PA 17013 USA. RP Terrill, WA (reprint author), US Army War Coll, Carlisle, PA 17013 USA. NR 1 TC 0 Z9 0 U1 0 U2 3 PU MIDDLE EAST INST PI WASHINGTON PA 1761 N ST NW, CIRCULATION DEPT, WASHINGTON, DC 20036-2882 USA SN 0026-3141 J9 MIDDLE EAST J JI Middle East J. PD WIN PY 2014 VL 68 IS 1 BP 175 EP 176 PG 2 WC Area Studies SC Area Studies GA AG2UD UT WOS:000335271700020 ER PT J AU Knorr, DB Williams, KS Baril, NF Weiland, C Andzelm, JW Lenhart, JL Woicik, JC Fischer, DA Tidrow, MZ Bandara, SV Henry, NC AF Knorr, Daniel B., Jr. Williams, Kristen S. Baril, Neil F. Weiland, Conan Andzelm, Jan W. Lenhart, Joseph L. Woicik, Joseph C. Fischer, Daniel A. Tidrow, Meimei Z. Bandara, Sumith V. Henry, Nathan C. TI Use of 3-aminopropyltriethoxysilane deposited from aqueous solution for surface modification of III-V materials SO APPLIED SURFACE SCIENCE LA English DT Article DE III/V materials; Aminopropylsilane; Surface passivation; NEXAFS; XPS; InAs; GaSb ID RAY PHOTOELECTRON-SPECTRA; SELF-ASSEMBLED MONOLAYERS; CHEMICAL DEPTH PROFILE; SUPERLATTICE PHOTODIODES; GEOMETRY OPTIMIZATION; HYDROGEN ADSORPTION; MOLECULAR-STRUCTURE; SULFUR PASSIVATION; CO2 ADSORPTION; XPS METHOD AB Focal plane arrays of strained layer superlattices (SLSs) composed of InAs/GaSb are excellent candidates for infrared imaging, but one key factor limiting their utility is the lack of a surface passivation technique capable of protecting the mesa sidewall from degradation. Along these lines, we demonstrate the use of aqueous 3-aminopropyl triethoxysilane (APTES) deposited as a surface functionalizing agent for subsequent polymer passivation on InAs and GaSb surfaces following a HCl/citric acid procedure to remove the conductive oxide In2O3. Using atomic force microscopy, variable angle spectroscopic ellipsometry, X-ray photoelectron spectroscopy (XPS), near-edge X-ray absorption fine structure (NE)(AFS), and modeling with density functional theory (DFT), we demonstrate that APTES films can successfully be deposited on III-V substrates by spin coating and directly compare these films to those deposited on silicon substrates. The HCl/citric acid surface preparation treatment is particularly effective at removing In2O3 without the surface segregation of In oxides observed from use of HCl alone. However, HCl/citric acid surface treatment method does result in heavy oxidation of both Ga and Sb, accompanied by segregation of Ga oxide to the surface. Deposited APTES layer thickness did not depend on the substrate choice, and thicknesses between 1 and 20 nm were obtained for APTES solution concentrations ranging from 0.1 to 2.5 vol %. XPS results for the N1s band of APTES showed that the content of ionic nitrogen was high (similar to 50%) for the thinnest films (similar to 1 nm), and decreased with increasing film thickness. These results indicate that APTES can indeed be used to form a silane surface layer to cover III-V materials substrates. Such APTES silane layers may prove useful in surface passivation of these materials alone, or as surface functionalizing agents for subsequent covalent binding with polymer overlayers like polyimide. Published by Elsevier B.V. C1 [Knorr, Daniel B., Jr.; Williams, Kristen S.; Andzelm, Jan W.; Lenhart, Joseph L.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Baril, Neil F.; Tidrow, Meimei Z.; Bandara, Sumith V.; Henry, Nathan C.] US Army, RDECOM, CERDEC, NVSED, Ft Belvoir, VA 22060 USA. [Weiland, Conan; Lenhart, Joseph L.; Woicik, Joseph C.] NIST, Gaithersburg, MD 20899 USA. [Henry, Nathan C.] Corbin Co, Alexandria, VA 22314 USA. RP Knorr, DB (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM daniel.knorr.civ@mail.mil; joseph.l.lenhart.civ@mail.mil RI Weiland, Conan/K-4840-2012 FU U.S. Army Research Laboratory; U.S. Army Communications-Electronics Research Development and Engineering Center CDIF program; U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-98CH10886]; Postgraduate Research Participation Program at the U.S. Army Research Laboratory (USARL); U.S. Department of Energy; USARL; DoD High Performance Computing Modernization Programs at the U.S. Army Research Laboratory; U.S. Air Force Research Laboratory DoD Supercomputing Resource Centers FX This work was supported by the U.S. Army Research Laboratory and the U.S. Army Communications-Electronics Research Development and Engineering Center CDIF program. Use of the National Synchrotron Light Source, Brookhaven National Laboratory, was supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No. DE-AC02-98CH10886. K. W. was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory (USARL) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARL. Modeling studies were supported in part by grants of computer time from the DoD High Performance Computing Modernization Programs at the U.S. Army Research Laboratory and U.S. Air Force Research Laboratory DoD Supercomputing Resource Centers. NR 66 TC 2 Z9 2 U1 8 U2 55 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-4332 EI 1873-5584 J9 APPL SURF SCI JI Appl. Surf. Sci. PD NOV 30 PY 2014 VL 320 BP 414 EP 428 DI 10.1016/j.apsusc.2014.09.055 PG 15 WC Chemistry, Physical; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter SC Chemistry; Materials Science; Physics GA AU1SG UT WOS:000345399900054 ER PT J AU Peddada, LY Garbuzenko, OB Devore, DI Minko, T Roth, CM AF Peddada, Lavanya Y. Garbuzenko, Olga B. Devore, David I. Minko, Tamara Roth, Charles M. TI Delivery of antisense oligonucleotides using poly(alkylene oxide)-poly(propylacrylic acid) graft copolymers in conjunction with cationic liposomes SO JOURNAL OF CONTROLLED RELEASE LA English DT Article DE Antisense; Gene silencing; Nanoparticle; Drug delivery; Self assembly; Tumor ID GENE-DELIVERY; INTRACELLULAR DELIVERY; POLYMERIC NANOPARTICLES; SERUM STABILITY; NUCLEIC-ACIDS; IN-VIVO; CANCER; THERAPY; COMPLEXES; TUMOR AB The clinical application of gene silencing is hindered by poor stability and low delivery efficiency of naked oligo-nucleotides. Here, we present the in vitro and in vivo behaviors of a rationally designed, ternary, self-assembled nanoparticle complex, consisting of an anionic copolymer, cationic DOTAP liposome, and antisense oligonucleotide (AON). The multifunctional copolymers are based on backbone poly(propylacrylic acid) (PPAA), a pH-sensitive hydrophobic polymer, with grafted poly(alkylene oxides) (PAOs) varying in extent of grafting and PAO chemistry. The nanoparticle complexes with PPAA-g-PAO copolymers enhance antisense gene silencing effects in A2780 human ovarian cancer cells. A greater amount of AON is delivered to ovarian tumor xenografts using the ternary copolymer-stabilized delivery system, compared to a binary DOTAP/AON complex, following intraperitoneal injection in mice. Further, intratumoral injection of the nanoparticle complexes containing 1 mol% grafted PAO reduced tumoral bcl-2 expression by up to 60%. The data for complexes across the set of PAO polymers support a strong role for the hydrophilic-lipophilic balance of the graft copolymer in achieving serum stability and cellular uptake. Based upon these results, we anticipate that this novel nanoparticle delivery system can be extended to the delivery of plasmid DNA, siRNA, or aptamers for preclinical and clinical development. (C) 2014 Elsevier B.V. All rights reserved. C1 [Peddada, Lavanya Y.; Roth, Charles M.] Rutgers State Univ, Dept Biomed Engn, Piscataway, NJ USA. [Garbuzenko, Olga B.; Minko, Tamara] Rutgers State Univ, Dept Pharmaceut, Piscataway, NJ USA. [Roth, Charles M.] Rutgers State Univ, Dept Chem & Biochem Engn, Piscataway, NJ USA. [Devore, David I.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Roth, CM (reprint author), 599 Taylor Rd, Piscataway, NJ 08854 USA. EM cmroth@rutgers.edu OI Roth, Charles/0000-0002-4924-0721 FU NIH [2R01 EB008278]; New Jersey Commission for Cancer Research FX We gratefully acknowledge financial support from NIH Grant 2R01 EB008278 and a fellowship from the New Jersey Commission for Cancer Research to LP. We thank Professor Joachim Kohn for access to polymer synthesis facilities at the New Jersey Center for Biomaterials and are indebted to Drs. Abraham Joy and Marius Costache for their assistance with polymer synthesis and characterization. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. NR 56 TC 9 Z9 9 U1 4 U2 48 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-3659 EI 1873-4995 J9 J CONTROL RELEASE JI J. Control. Release PD NOV 28 PY 2014 VL 194 BP 103 EP 112 DI 10.1016/j.jconrel.2014.08.023 PG 10 WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy SC Chemistry; Pharmacology & Pharmacy GA AS4FU UT WOS:000344229800010 PM 25192941 ER PT J AU Rutvisuttinunt, W Chinnawirotpisan, P Klungthong, C Shrestha, SK Thapa, AB Pant, A Yingst, SL Yoon, IK Fernandez, S Pavlin, JA AF Rutvisuttinunt, Wiriya Chinnawirotpisan, Piyawan Klungthong, Chonticha Shrestha, Sanjaya Kumar Thapa, Amod Bahadur Pant, Arjun Yingst, Samuel L. Yoon, In-Kyu Fernandez, Stefan Pavlin, Julie A. TI Evidence of West Nile virus infection in Nepal SO BMC INFECTIOUS DISEASES LA English DT Article DE West nile virus; Nepal; Febrile illness; Deep sequencing; NGS; Phylogeny ID DYNAMICS; LINEAGE AB Background: Acute febrile illness is common among those seeking medical care and is frequently treated empirically with the underlying illness remaining undiagnosed in resource-poor countries. A febrile illness study was conducted 2009-2010 to identify known and unknown pathogens circulating in Nepal. Method: Study methods included diagnostic testing and preliminary ELISA screening of acute and convalescent samples for diseases both known and unknown to be circulating in Nepal, including West Nile virus (WNV). The molecular assays including Polymerase Chain Reaction (PCR), Sanger sequencing and ultra deep sequencing on MiSeq Illumina Platform were conducted to further confirm the presence of WNV. Results: The study enrolled 2,046 patients presenting undifferentiated febrile illness with unknown etiology. Sera from 14 out of 2,046 patients were tested positive for west nile virus (WNV) by nested Reverse Transcription-Polymerase Chain Reaction (RT-PCR). Only two out of 14 cases were confirmed for the presence of WNV by sequencing and identified as WNV lineage 1 phylogentically. The two patients were adult males with fever and no neurological symptoms from Kathmandu and Bharatpur, Nepal. Conclusion: Two out of 2,046 serum samples contained fragments of WNV genome resembling WNV lineage 1, which is evidence of the continued spread of WNV which should be considered a possible illness cause in Nepal. C1 [Rutvisuttinunt, Wiriya; Chinnawirotpisan, Piyawan; Klungthong, Chonticha; Yingst, Samuel L.; Yoon, In-Kyu; Fernandez, Stefan] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Shrestha, Sanjaya Kumar] Walter Reed AFRIMS Res Unit Nepal, Kathmandu, Nepal. [Thapa, Amod Bahadur] Bharatpur Hosp, Chitwan, Nepal. [Pant, Arjun] Sukra Raj Trop Infect Dis Hosp, Kathmandu, Nepal. [Pavlin, Julie A.] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD USA. RP Rutvisuttinunt, W (reprint author), Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. EM wiriyar@afrims.org; julie.a.pavlin.civ@mail.mil FU Armed Forces Health Surveillance Center - Global Emerging Infections Surveillance and Response System (AFHSC-GEIS) FX We would like to thank Armed Forces Health Surveillance Center - Global Emerging Infections Surveillance and Response System (AFHSC-GEIS) for financial support, staff at WARUN for subject enrolment, sample processing and information management, staff at AFRIMS for clinical information, processing WNV isolates and laboratory technical assistance on nucleic acid measurement, and the bioinformatics team at Los Alamos National Laboratory, Naval Medical Research Center and Prince of Songkla University for Bioinformatics consultation. The views expressed in this article are those of the authors and do not represent the official policy or position of the US Department of the Army, Department of Defense, or US Government. NR 16 TC 2 Z9 2 U1 0 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD NOV 27 PY 2014 VL 14 AR 606 DI 10.1186/s12879-014-0606-0 PG 6 WC Infectious Diseases SC Infectious Diseases GA AZ5CC UT WOS:000348236800001 PM 25427544 ER PT J AU Seo, DM Boyle, PD Sommer, RD Daubert, JS Borodin, O Henderson, WA AF Seo, Daniel M. Boyle, Paul D. Sommer, Roger D. Daubert, James S. Borodin, Oleg Henderson, Wesley A. TI Solvate Structures and Spectroscopic Characterization of LiTFSI Electrolytes SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID BIS(TRIFLUOROMETHANESULFONYL) IMIDE ANION; IONIC LIQUID; LITHIUM-ION; PHASE-BEHAVIOR; 1-BUTYL-3-METHYLIMIDAZOLIUM BIS(TRIFLUOROMETHANESULFONYL)IMIDE; COMPUTATIONAL/SPECTROSCOPIC CHARACTERIZATION; POLYMER ELECTROLYTES; TRANSPORT-PROPERTIES; RAMAN-SPECTROSCOPY; DFT CALCULATIONS AB A Raman spectroscopic evaluation of numerous crystalline solvates with lithium bis(trifluoromethanesulfonyl)imide (LiTFSI or LiN(SO2CF3)(2)) has been conducted over a wide temperature range. Four new crystalline solvate structures-(PHEN)(3):LiTFSI, (2,9-DMPHEN)(2):LiTFSI, (G3)(1):LiTFSI and (2,6-DMPy)(1/2):LiTFSI with phenanthroline, 2,9-dimethyl[1,10]phenanthroline, triglyme, and 2,6-dimethylpyridine, respectively-have been determined to aid in this study. The spectroscopic data have been correlated with varying modes of TFSI-center dot center dot center dot Li+ cation coordination within the solvate structures to create an electrolyte characterization tool to facilitate the Raman band deconvolution assignments for the determination of ionic association interactions within electrolytes containing LiTFSI. It is found, however, that significant difficulties may be encountered when identifying the distributions of specific forms of TFSI- anion coordination present in liquid electrolyte mixtures due to the wide range of TFSI-center dot center dot center dot Li+ cation interactions possible and the overlap of the corresponding spectroscopic data signatures. C1 [Seo, Daniel M.; Daubert, James S.; Henderson, Wesley A.] N Carolina State Univ, Dept Chem & Biomol Engn, Ion Liquids & Elect Energy Technol ILEET Lab, Raleigh, NC 27695 USA. [Boyle, Paul D.; Sommer, Roger D.] N Carolina State Univ, Dept Chem, Xray Struct Facil, Raleigh, NC 27695 USA. [Borodin, Oleg] US Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA. [Henderson, Wesley A.] PNNL, Electrochem Mat & Syst Grp, Energy & Environm Directorate, Richland, WA 99352 USA. RP Henderson, WA (reprint author), N Carolina State Univ, Dept Chem & Biomol Engn, Ion Liquids & Elect Energy Technol ILEET Lab, Raleigh, NC 27695 USA. EM Wesley.Henderson@pnnl.gov RI Borodin, Oleg/B-6855-2012; OI Borodin, Oleg/0000-0002-9428-5291; Daubert, James/0000-0002-8151-9191 FU U.S. Department of Energy (DOE) Office of Basic Energy Science-Division of Materials Sciences and Engineering [DE-SC0002169] FX The authors wish to express their gratitude to the U.S. Department of Energy (DOE) Office of Basic Energy Science-Division of Materials Sciences and Engineering which fully supported the experimental research under Award DE-SC0002169. NR 44 TC 20 Z9 20 U1 7 U2 58 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1520-6106 J9 J PHYS CHEM B JI J. Phys. Chem. B PD NOV 27 PY 2014 VL 118 IS 47 SI SI BP 13601 EP 13608 DI 10.1021/jp505006x PG 8 WC Chemistry, Physical SC Chemistry GA AU6OU UT WOS:000345722900035 PM 25345716 ER PT J AU Hooper, JW Brocato, RL Kwilas, SA Hammerbeck, CD Josleyn, MD Royals, M Ballantyne, J Wu, H Jiao, JA Matsushita, H Sullivan, EJ AF Hooper, Jay W. Brocato, Rebecca L. Kwilas, Steven A. Hammerbeck, Christopher D. Josleyn, Matthew D. Royals, Michael Ballantyne, John Wu, Hua Jiao, Jin-an Matsushita, Hiroaki Sullivan, Eddie J. TI DNA vaccine-derived human IgG produced in transchromosomal bovines protect in lethal models of hantavirus pulmonary syndrome SO SCIENCE TRANSLATIONAL MEDICINE LA English DT Article ID SIN-NOMBRE-VIRUS; NEUTRALIZING ANTIBODY-RESPONSE; TO-PERSON TRANSMISSION; ANDES VIRUS; UNITED-STATES; INCUBATION PERIOD; NONHUMAN-PRIMATES; SYRIAN-HAMSTERS; RHESUS MACAQUES; DISEASE-MODEL AB Polyclonal immunoglobulin-based medical products have been used successfully to treat diseases caused by viruses for more than a century. We demonstrate the use of DNA vaccine technology and transchromosomal bovines (TcBs) to produce fully human polyclonal immunoglobulins (IgG) with potent antiviral neutralizing activity. Specifically, two hantavirus DNA vaccines [Andes virus (ANDV) DNA vaccine and Sin Nombre virus (SNV) DNA vaccine] were used to produce a candidate immunoglobulin product for the prevention and treatment of hantavirus pulmonary syndrome (HPS). A needle-free jet injection device was used to vaccinate TcB, and high-titer neutralizing antibodies (titers >1000) against both viruses were produced within 1 month. Plasma collected at day 10 after the fourth vaccination was used to produce purified alpha-HPS TcB human IgG. Treatment with 20,000 neutralizing antibody units (NAU)/kg starting 5 days after challenge with ANDV protected seven of eight animals, whereas zero of eight animals treated with the same dose of normal TcB human IgG survived. Likewise, treatment with 20,000 NAU/kg starting 5 days after challenge with SNV protected immunocompromised hamsters from lethal HPS, protecting five of eight animals. Our findings that the alpha-HPS TcB human IgG is capable of protecting in animal models of lethal HPS when administered after exposure provides proof of concept that this approach can be used to develop candidate next-generation polyclonal immunoglobulin-based medical products without the need for human donors, despeciation protocols, or inactivated/attenuated vaccine antigen. C1 [Hooper, Jay W.; Brocato, Rebecca L.; Kwilas, Steven A.; Hammerbeck, Christopher D.; Josleyn, Matthew D.] US Army Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21709 USA. [Royals, Michael] Cedar Ind, Pierce, CO 80650 USA. [Wu, Hua; Jiao, Jin-an; Matsushita, Hiroaki; Sullivan, Eddie J.] SAB Biotherapeut Inc, Sioux Falls, SD 57104 USA. RP Hooper, JW (reprint author), US Army Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21709 USA. EM jay.w.hooper.civ@mail.mil OI Hooper, Jay/0000-0002-4475-0415 FU internal SAB funding; Military Infectious Disease Research Program, Program Area T FX This work was supported by internal SAB funding and by funding from the Military Infectious Disease Research Program, Program Area T. NR 50 TC 10 Z9 10 U1 0 U2 11 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 1946-6234 EI 1946-6242 J9 SCI TRANSL MED JI Sci. Transl. Med. PD NOV 26 PY 2014 VL 6 IS 264 AR 264ra162 DI 10.1126/scitranslmed.3010082 PG 9 WC Cell Biology; Medicine, Research & Experimental SC Cell Biology; Research & Experimental Medicine GA AU4PY UT WOS:000345595200002 PM 25429055 ER PT J AU Li, W Birdwell, AG Amani, M Burke, RA Ling, X Lee, YH Liang, XL Peng, LM Richter, CA Kong, J Gundlach, DJ Nguyen, NV AF Li, Wei Birdwell, A. Glen Amani, Matin Burke, Robert A. Ling, Xi Lee, Yi-Hsien Liang, Xuelei Peng, Lianmao Richter, Curt A. Kong, Jing Gundlach, David J. Nguyen, N. V. TI Broadband optical properties of large-area monolayer CVD molybdenum disulfide SO PHYSICAL REVIEW B LA English DT Article ID SINGLE-LAYER MOS2; CHEMICAL-VAPOR-DEPOSITION; HIGH-QUALITY MONOLAYER; ELECTRONIC-STRUCTURE; ATOMIC LAYERS; BILAYER MOS2; SOLAR-CELLS; PHOTOLUMINESCENCE; PHOTOTRANSISTORS; TRANSISTORS AB Recently emerging large-area single-layer MoS2 grown by chemical vapor deposition has triggered great interest due to its exciting potential for applications in advanced electronic and optoelectronic devices. Unlike gapless graphene, MoS2 has an intrinsic band gap in the visible which crosses over from an indirect to a direct gap when reduced to a single atomic layer. In this paper, we report a comprehensive study of fundamental optical properties of MoS2 revealed by optical spectroscopy of Raman, photoluminescence, and vacuum ultraviolet spectroscopic ellipsometry. A band gap of 1.42 eV is determined by the absorption threshold of bulk MoS2 that shifts to 1.83 eV in monolayer MoS2. We extracted the high precision dielectric function up to 9.0 eV, which leads to the identification of many unique interband transitions at high symmetry points in the MoS2 momentum space. The positions of the so-called A and B excitons in single layers are found to shift upwards in energy compared with those of the bulk form and have smaller separation because of the decreased interactions between the layers. A very strong optical critical point predicted to correspond to a quasiparticle gap is observed at 2.86 eV, which is attributed to optical transitions along the parallel bands between the M and Gamma points in the reduced Brillouin zone. The absence of the bulk MoS2 spin-orbit interaction peak at similar to 3.0 eV in monolayer MoS2 is, as predicted, the consequence of the coalescence of nearby excitons. A higher energy optical transition at 3.98 eV, commonly occurring in bulk semiconductors, is associated with a combination of several critical points. Additionally, extending into the vacuum ultraviolet energy spectrum are a series of newly observed oscillations representing optical transitions from valence bands to higher conduction bands of the monolayer MoS2 complex band structure. These optical transitions herein reported enhance our understanding of monolayer MoS2 as well as of two-dimensional systems in general and thus provide informative guidelines for MoS2 optical device designs and theoretical considerations. C1 [Li, Wei; Richter, Curt A.; Gundlach, David J.; Nguyen, N. V.] NIST, Semicond & Dimens Metrol Div, Gaithersburg, MD 20899 USA. [Li, Wei; Liang, Xuelei; Peng, Lianmao] Peking Univ, Key Lab Phys & Chem Nanodevices, Beijing 100871, Peoples R China. [Li, Wei; Liang, Xuelei; Peng, Lianmao] Peking Univ, Dept Elect, Beijing 100871, Peoples R China. [Birdwell, A. Glen; Amani, Matin; Burke, Robert A.] US Army, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. [Ling, Xi; Lee, Yi-Hsien; Kong, Jing] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA. [Lee, Yi-Hsien] Natl Tsing Hua Univ, Hsinchu 30013, Taiwan. RP Li, W (reprint author), NIST, Semicond & Dimens Metrol Div, Gaithersburg, MD 20899 USA. EM liangxl@pku.edu.cn; nhan.nguyen@nist.gov RI Peng, Lianmao/E-2089-2011; Liang, Xuelei/C-4690-2013 FU Ministry of Science and Technology of China (STC) [2011CB921904]; Ministry of education of China [113003A]; Natural Science Foundation (NSF) of China [61321001]; Beijing Municipal Science and Technology Commission [Z141100003814006]; National Institute of Standards and Technology; STC Center for Integrated Quantum Materials from NSF [DMR-1231319]; US Army Research Laboratory (ARL) Director's Strategic Initiative program FX This work was supported by the Ministry of Science and Technology of China (STC) (Grant No. 2011CB921904), the Ministry of education of China (Grant No. 113003A) Natural Science Foundation (NSF) of China (Grant No. 61321001), and Beijing Municipal Science and Technology Commission (Grant No. Z141100003814006). W. L. was partly supported by the National Institute of Standards and Technology. J.K. acknowledges the support through the STC Center for Integrated Quantum Materials from NSF Grant No. DMR-1231319. A.G.B., M.A., and R.A.B. were supported by the US Army Research Laboratory (ARL) Director's Strategic Initiative program on interfaces in stacked 2D atomic layered materials. NR 50 TC 19 Z9 19 U1 6 U2 114 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 EI 1550-235X J9 PHYS REV B JI Phys. Rev. B PD NOV 21 PY 2014 VL 90 IS 19 AR 195434 DI 10.1103/PhysRevB.90.195434 PG 8 WC Physics, Condensed Matter SC Physics GA AU6WS UT WOS:000345742800005 ER PT J AU Nyenswah, T Fahnbulleh, M Massaquoi, M Nagbe, T Bawo, L Falla, JD Kohar, H Gasasira, A Nabeth, P Yett, S Gergonne, B Casey, S Espinosa, B McCoy, A Feldman, H Hensley, L Baily, M Fields, B Lo, T Lindblade, K Mott, J Boulanger, L Christie, A Wang, SS Montgomery, J Mahoney, F AF Nyenswah, Tolbert Fahnbulleh, Miatta Massaquoi, Moses Nagbe, Thomas Bawo, Luke Falla, James Dorbor Kohar, Henry Gasasira, Alex Nabeth, Pierre Yett, Sheldon Gergonne, Bernadette Casey, Sean Espinosa, Benjamin McCoy, Andrea Feldman, Heinz Hensley, Lisa Baily, Mark Fields, Barry Lo, Terrence Lindblade, Kim Mott, Josh Boulanger, Lucy Christie, Athalia Wang, Susan Montgomery, Joel Mahoney, Frank TI Ebola Epidemic - Liberia, March-October 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID DISEASE OUTBREAK; VIRUS DISEASE C1 [Nyenswah, Tolbert; Fahnbulleh, Miatta; Massaquoi, Moses; Nagbe, Thomas; Bawo, Luke; Falla, James Dorbor; Kohar, Henry] Minist Hlth & Social Welf, Monrovia, Liberia. [Gasasira, Alex; Nabeth, Pierre] World Hlth Org, Geneva, Switzerland. [Yett, Sheldon] United Nations Childrens Fund, New York, NY USA. [Gergonne, Bernadette] Medecins Sans Frontieres, Geneva, Switzerland. [Casey, Sean] Int Med Corps, Los Angeles, CA USA. [Espinosa, Benjamin; McCoy, Andrea] US Navy, Pentagon, AR USA. [Feldman, Heinz; Hensley, Lisa] Natl Inst Hlth, Bethesda, MD USA. [Baily, Mark] US Army Med Res Inst Infect Dis, Ft Detroit, MD USA. [Fields, Barry; Lo, Terrence; Lindblade, Kim; Mott, Josh; Boulanger, Lucy; Christie, Athalia; Wang, Susan; Montgomery, Joel; Mahoney, Frank] CDC, Atlanta, GA 30333 USA. RP Mahoney, F (reprint author), CDC, Atlanta, GA 30333 USA. EM fmahoney@cdc.gov NR 5 TC 15 Z9 16 U1 0 U2 14 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD NOV 21 PY 2014 VL 63 IS 46 BP 1082 EP 1086 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AU3LO UT WOS:000345514900009 PM 25412068 ER PT J AU Nyenswah, T Fahnbulleh, M Ketah, F Massaquoi, M Nagbe, T Bawo, L Falla, JD Kohar, H Gasasira, A Nabeth, P Popowitz, H Yett, S Hurum, L Sailly, L Casey, S Espinosa, B Mccoy, A Feldman, H Hensley, L Baily, M Pendarvis, J Fields, B Lo, T Quin, J Aberle-Grasse, J Lindblade, K Mott, J Boulanger, L Christie, A Wang, SS Montgomery, J Mahoney, F AF Nyenswah, Tolbert Fahnbulleh, Miatta Ketah, Francis Massaquoi, Moses Nagbe, Thomas Bawo, Luke Falla, James Dorbor Kohar, Henry Gasasira, Alex Nabeth, Pierre Popowitz, Heather Yett, Sheldon Hurum, Lindis Sailly, Laurence Casey, Sean Espinosa, Benjamin McCoy, Andrea Feldman, Heinz Hensley, Lisa Baily, Mark Pendarvis, Justin Fields, Barry Lo, Terrence Quin, Jin Aberle-Grasse, John Lindblade, Kim Mott, Josh Boulanger, Lucy Christie, Athalia Wang, Susan Montgomery, Joel Mahoney, Frank TI Ebola Epidemic - Liberia, March-October 2014 (vol 63, pg 1082, 2014) SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Correction C1 [Nyenswah, Tolbert; Fahnbulleh, Miatta; Ketah, Francis; Massaquoi, Moses; Nagbe, Thomas; Bawo, Luke; Falla, James Dorbor; Kohar, Henry] Minist Hlth & Social Welf, Monrovia, Liberia. [Gasasira, Alex; Nabeth, Pierre] World Hlth Org, Geneva, Switzerland. [Popowitz, Heather; Yett, Sheldon] United Nations Childrens Fund, New York, NY USA. [Hurum, Lindis; Sailly, Laurence] Medecins Sans Frontieres, Geneva, Switzerland. [Casey, Sean] Int Med Corps, Los Angeles, CA USA. [Espinosa, Benjamin; McCoy, Andrea] US Navy, Pentagon, AR USA. [Feldman, Heinz; Hensley, Lisa] Natl Inst Hlth, Atlanta, GA USA. [Baily, Mark] US Army Med Res Inst Infect Dis, Ft Detroit, MD USA. [Pendarvis, Justin] US Agcy Int Dev, Washington, DC 20523 USA. [Fields, Barry; Lo, Terrence; Quin, Jin; Aberle-Grasse, John; Lindblade, Kim; Mott, Josh; Boulanger, Lucy; Christie, Athalia; Wang, Susan; Montgomery, Joel; Mahoney, Frank] CDC, Atlanta, GA 30333 USA. RP Nyenswah, T (reprint author), Minist Hlth & Social Welf, Monrovia, Liberia. NR 1 TC 2 Z9 2 U1 0 U2 3 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD NOV 21 PY 2014 VL 63 IS 46 BP 1094 EP 1094 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AU3LO UT WOS:000345514900012 ER PT J AU Kester, KE Heppner, DG Moris, P Ofori-Anyinam, O Krzych, U Tornieporth, N McKinney, D Delchambre, M Ockenhouse, CF Voss, G Holland, C Beckey, JP Ballou, WR Cohen, J AF Kester, Kent E. Heppner, D. Gray, Jr. Moris, Philippe Ofori-Anyinam, Opokua Krzych, Urszula Tornieporth, Nadia McKinney, Denise Delchambre, Martine Ockenhouse, Christian F. Voss, Gerald Holland, Carolyn Beckey, Jolie Palensky Ballou, W. Ripley Cohen, Joe CA RTS TRAP Grp TI Sequential Phase 1 and Phase 2 randomized, controlled trials of the safety, immunogenicity and efficacy of combined pre-erythrocytic vaccine antigens RTS,S and TRAP formulated with AS02 Adjuvant System in healthy, malaria naive adults SO VACCINE LA English DT Article DE TRAP; RTS,S; AS02; Immune interference; Malaria vaccine; Challenge ID FALCIPARUM CIRCUMSPOROZOITE PROTEIN; SPOROZOITE SURFACE PROTEIN-2; PRIME-BOOST IMMUNIZATION; INSTITUTE-OF-RESEARCH; CD4(+) T-CELL; PLASMODIUM-FALCIPARUM; VIRUS ANKARA; RECOMBINANT PROTEIN; ANTIBODY-RESPONSES; AFRICAN CHILDREN AB In an attempt to improve the efficacy of the candidate malaria vaccine RTS,S/AS02, two studies were conducted in 1999 in healthy volunteers of RTS,S/AS02 in combination with recombinant Plasmodium falciparum thrombospondin-related anonymous protein (TRAP). In a Phase 1 safety and immunogenicity study, volunteers were randomized to receive TRAP/AS02 (N = 10), RTS,S/AS02 (N = 10), or RTS,S + TRAP/AS02 (N = 20) at 0,1 and 6-months. In a Phase 2 challenge study, subjects were randomized to receive either RTS,S + TRAP/AS02 (N = 25) or TRAP/AS02 (N = 10) at 0 and 1-month, or to a challenge control group (N = 8). In both studies, the combination vaccine had an acceptable safety profile and was acceptably tolerated. Antigen-specific antibodies, lymphoproliferative responses, and IFN-gamma production by ELISPOT assay elicited with the combination vaccine were qualitatively similar to those generated by the single component vaccines. However, post-dose 2 anti-CS antibodies in the RTS,S + TRAP/AS02 vaccine recipients were lower than in the RTS,S/AS02 vaccine recipients. After challenge, 10 of 11 RTS,S + TRAP/AS02 vaccinees, 5 of 5 TRAP/AS02 vaccinees, and 8 of 8 infectivity controls developed parasitemia, with median pre-patent periods of 13.0, 11.0, and 12.0 days, respectively. The absence of any prevention or delay of parasitemia by TRAP/AS02 suggests no apparent added value of TRAP/AS02 as a candidate vaccine. The absence of significant protection or delay of parasitemia in the 11 RTS,S + TRAP/AS02 vaccine recipients contrasts with previous 2 dose studies of RTS,S/AS02. The small sample size did not permit identifying statistically significant differences between the study arms. However, we speculate, within the constraints of the challenge study, that the presence of the TRAP antigen may have interfered with the vaccine efficacy previously observed with this regimen of RTS,S/AS02, and that any future TRAP-based vaccines should consider employing alternative vaccine platforms. (C) 2014 The Authors. Published by Elsevier Ltd. C1 [Kester, Kent E.; Heppner, D. Gray, Jr.; Krzych, Urszula; McKinney, Denise; Ockenhouse, Christian F.; Holland, Carolyn; Ballou, W. Ripley] Walter Reed Army Inst Res, Silver Spring, MD USA. [Moris, Philippe; Ofori-Anyinam, Opokua; Tornieporth, Nadia; Delchambre, Martine; Voss, Gerald; Cohen, Joe] GlaxoSmithKline Biol, Rixensart, Belgium. [Beckey, Jolie Palensky] Stat Collaborat Inc, Washington, DC USA. RP Kester, KE (reprint author), Sanofi Pasteur, Discovery Dr, Swiftwater, PA 18370 USA. EM kent.kester@usuhs.edu; grayheppner@gmail.com; philippe.moris@gsk.com; opokua.ofori-anyinam@gsk.com; urszula.krzych1@us.army.mil; nadia.tornieporth@sanofipasteur.com; deniseam52@gmail.com; martine.delchambre@gsk.com; cockenhouse@path.org; gerald.voss@gsk.com; carolyn.holland@us.army.mil; alexandjolie@gmail.com; ripley.w.ballou@gsk.com; joe.cohen@gsk.com FU GlaxoSmithKline Biologicals, Rixensart, Belgium; United States Army Medical Materiel Development Activity, Ft. Detrick, Maryland FX Financial support for the Phase I study was provided by GlaxoSmithKline Biologicals, Rixensart, Belgium. Financial support for the Phase II study was provided by the United States Army Medical Materiel Development Activity, Ft. Detrick, Maryland, and by GlaxoSmithKline Biologicals, Rixensart, Belgium. NR 45 TC 9 Z9 9 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD NOV 20 PY 2014 VL 32 IS 49 BP 6683 EP 6691 DI 10.1016/j.vaccine.2014.06.033 PG 9 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA AU8BD UT WOS:000345820800016 PM 24950358 ER PT J AU Barouch, DH Michael, NL AF Barouch, Dan H. Michael, Nelson L. TI Accelerating HIV-1 Vaccine Efficacy Trials SO CELL LA English DT Editorial Material ID DOUBLE-BLIND; GAG/POL/NEF VACCINE; HVTN 503/PHAMBILI; RHESUS-MONKEYS; SOUTH-AFRICA; PHASE 2H; INFECTION; CHALLENGES C1 [Barouch, Dan H.] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02215 USA. [Barouch, Dan H.] MIT, Ragon Inst MGH, Cambridge, MA 02139 USA. [Barouch, Dan H.] Harvard, Cambridge, MA 02139 USA. [Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. RP Barouch, DH (reprint author), Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02215 USA. EM dbarouch@bidmc.harvard.edu; nmichael@hivresearch.org FU NIAID NIH HHS [R01 AI084794, U19 AI078526, U19 AI095985, U19 AI096040] NR 13 TC 9 Z9 9 U1 2 U2 17 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 0092-8674 EI 1097-4172 J9 CELL JI Cell PD NOV 20 PY 2014 VL 159 IS 5 BP 969 EP 972 DI 10.1016/j.cell.2014.10.046 PG 4 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA AU3IP UT WOS:000345506300008 PM 25416935 ER PT J AU Ananworanich, J Robb, ML AF Ananworanich, Jintanat Robb, Merlin L. TI The transient HIV remission in the Mississippi baby: why is this good news? SO JOURNAL OF THE INTERNATIONAL AIDS SOCIETY LA English DT Editorial Material ID LATENT RESERVOIR; CURE C1 [Ananworanich, Jintanat; Robb, Merlin L.] US Mil Acad, Walter Reed Army Inst Res, HIV Res Program, Silver Spring, MD USA. [Ananworanich, Jintanat; Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. RP Ananworanich, J (reprint author), US Mil Acad, HIV Res Program, 6720A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA. EM jananworanich@hivresearch.org NR 13 TC 2 Z9 2 U1 1 U2 6 PU INT AIDS SOCIETY PI GENEVA PA AVENUE DE FRANCE 23, GENEVA, 1202, SWITZERLAND SN 1758-2652 J9 J INT AIDS SOC JI J. Int. AIDS Soc. PD NOV 20 PY 2014 VL 17 AR 19859 DI 10.7448/IAS.17.1.19859 PG 2 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AU3HB UT WOS:000345501900001 PM 25416415 ER PT J AU Shaw, M Yu, KM Ting, M Powell, REL Sarney, WL Svensson, SP Kent, AJ Walukiewicz, W Foxon, CT Novikov, SV Martin, RW AF Shaw, M. Yu, K. M. Ting, M. Powell, R. E. L. Sarney, W. L. Svensson, S. P. Kent, A. J. Walukiewicz, W. Foxon, C. T. Novikov, S. V. Martin, R. W. TI Composition and optical properties of dilute-Sb GaN1-xSbx highly mismatched alloys grown by MBE SO JOURNAL OF PHYSICS D-APPLIED PHYSICS LA English DT Article DE molecular beam epitaxy; nitrides; semiconducting III-V materials; cathodoluminescence ID MOLECULAR-BEAM EPITAXY; NITRIDE; BAND; GAN AB In this work the compositional and optical characterization of three series of dilute-Sb GaN1-xSbx alloys grown with various Sb flux, under N and Ga-rich conditions, are presented. Using wavelength dispersive x-ray microanalysis and Rutherford backscattering spectroscopy it is found that the N-rich samples (Ga flux < 2.3 x 10(-7) Torr) incorporate a higher magnitude of GaSb than the Ga-rich samples (Ga flux > 2.3 x 10(-7) Torr) under the same growth conditions. The optical properties of the Ga-rich samples are measured using room temperature cathodoluminescence (CL), photoluminescence (PL) and absorption measurements. A broad luminescence peak is observed around 2.2 eV. The nature and properties of this peak are considered, as is the suitability of these dilute-Sb alloys for use in solar energy conversion devices. C1 [Shaw, M.; Martin, R. W.] Univ Strathclyde, Dept Phys, SUPA, Glasgow G4 0NG, Lanark, Scotland. [Yu, K. M.; Ting, M.; Walukiewicz, W.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA. [Ting, M.] Univ Calif Berkeley, Dept Mech Engn, Berkeley, CA 94720 USA. [Powell, R. E. L.; Foxon, C. T.; Novikov, S. V.] Univ Nottingham, Sch Phys & Astron, Nottingham NG7 2RD, England. [Sarney, W. L.; Svensson, S. P.] US Army, Res Lab, Adelphi, MD 20783 USA. RP Shaw, M (reprint author), Univ Strathclyde, Dept Phys, SUPA, Glasgow G4 0NG, Lanark, Scotland. EM martin.shaw@strath.ac.uk RI martin, rob/A-7127-2010; OI martin, rob/0000-0002-6119-764X; Kent, Anthony/0000-0002-2391-6869; Yu, Kin Man/0000-0003-1350-9642 FU EPSRC UK [EP/I004203/1, EP/I00467X/1]; US Army Foreign Technology Assessment Support (FTAS) program [W911NF-12-2-0003]; Office of Science, Office of Basic Energy Sciences, Materials Sciences and Engineering Division, of the US Department of Energy [DE-AC02-05CH11231] FX This work was undertaken with support from the EPSRC UK, under grant numbers EP/I004203/1 and EP/I00467X/1. The MBE growth at Nottingham was also supported by the US Army Foreign Technology Assessment Support (FTAS) program (grant W911NF-12-2-0003). The characterization work performed at LBNL was supported by the Director, Office of Science, Office of Basic Energy Sciences, Materials Sciences and Engineering Division, of the US Department of Energy under Contract No. DE-AC02-05CH11231. Data associated with research published in this paper can be accessed by contacting the corresponding author. NR 26 TC 3 Z9 3 U1 1 U2 9 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0022-3727 EI 1361-6463 J9 J PHYS D APPL PHYS JI J. Phys. D-Appl. Phys. PD NOV 19 PY 2014 VL 47 IS 46 AR 465102 DI 10.1088/0022-3727/47/46/465102 PG 7 WC Physics, Applied SC Physics GA AT3UG UT WOS:000344859800003 ER PT J AU Wu, TYH Singh, M Miller, AT De Gregorio, E Doro, F D'Oro, U Skibinski, DAG Mbow, ML Bufali, S Herman, AE Cortez, A Li, Y Nayak, BP Tritto, E Filippi, CM Otten, GR Brito, LA Monaci, E Li, C Aprea, S Valentini, S Calabro, S Laera, D Brunelli, B Caproni, E Malyala, P Panchal, RG Warren, TK Bavari, S O'Hagan, DT Cooke, MP Valiante, NM AF Wu, Tom Y. -H. Singh, Manmohan Miller, Andrew T. De Gregorio, Ennio Doro, Francesco D'Oro, Ugo Skibinski, David A. G. Mbow, M. Lamine Bufali, Simone Herman, Ann E. Cortez, Alex Li, Yongkai Nayak, Bishnu P. Tritto, Elaine Filippi, Christophe M. Otten, Gillis R. Brito, Luis A. Monaci, Elisabetta Li, Chun Aprea, Susanna Valentini, Sara Calabro, Samuele Laera, Donatello Brunelli, Brunella Caproni, Elena Malyala, Padma Panchal, Rekha G. Warren, Travis K. Bavari, Sina O'Hagan, Derek T. Cooke, Michael P. Valiante, Nicholas M. TI Rational design of small molecules as vaccine adjuvants SO SCIENCE TRANSLATIONAL MEDICINE LA English DT Article ID SEROGROUP-B MENINGOCOCCUS; NEISSERIA-MENINGITIDIS; RESIQUIMOD; IMMUNIZATION; AGONISTS; ASSAY; IDENTIFICATION; CANDIDATES; INFECTION; DISCOVERY AB Adjuvants increase vaccine potency largely by activating innate immunity and promoting inflammation. Limiting the side effects of this inflammation is a major hurdle for adjuvant use in vaccines for humans. It has been difficult to improve on adjuvant safety because of a poor understanding of adjuvant mechanism and the empirical nature of adjuvant discovery and development historically. We describe new principles for the rational optimization of small-molecule immune potentiators (SMIPs) targeting Toll-like receptor 7 as adjuvants with a predicted increase in their therapeutic indices. Unlike traditional drugs, SMIP-based adjuvants need to have limited bioavailability and remain localized for optimal efficacy. These features also lead to temporally and spatially restricted inflammation that should decrease side effects. Through medicinal and formulation chemistry and extensive immunopharmacology, we show that in vivo potency can be increased with little to no systemic exposure, localized innate immune activation and short in vivo residence times of SMIP-based adjuvants. This work provides a systematic and generalizable approach to engineering small molecules for use as vaccine adjuvants. C1 [Wu, Tom Y. -H.; Miller, Andrew T.; Herman, Ann E.; Cortez, Alex; Li, Yongkai; Nayak, Bishnu P.; Filippi, Christophe M.; Li, Chun; Cooke, Michael P.] Novartis Fdn, Genom Inst, San Diego, CA 92121 USA. [Singh, Manmohan; Mbow, M. Lamine; Otten, Gillis R.; Brito, Luis A.; Malyala, Padma; O'Hagan, Derek T.; Valiante, Nicholas M.] Novartis Vaccines, Cambridge, MA 02139 USA. [De Gregorio, Ennio; Doro, Francesco; D'Oro, Ugo; Skibinski, David A. G.; Bufali, Simone; Tritto, Elaine; Monaci, Elisabetta; Aprea, Susanna; Valentini, Sara; Calabro, Samuele; Laera, Donatello; Brunelli, Brunella; Caproni, Elena] Novartis Vaccines, I-53100 Siena, Italy. [Panchal, Rekha G.; Warren, Travis K.; Bavari, Sina] US Army Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Valiante, NM (reprint author), Novartis Vaccines, 45 Sidney St, Cambridge, MA 02139 USA. EM derek.ohagan@novartis.com; mcooke@gnf.org; nicholas.valiante@novartis.com FU Department of Defense Chemical and Biological Defense program through the Defense Threat Reduction Agency [HDTRA1-07-9-0001] FX This work was supported in part by the Transformational Medical Technologies program contract HDTRA1-07-9-0001 from the Department of Defense Chemical and Biological Defense program through the Defense Threat Reduction Agency. NR 39 TC 33 Z9 33 U1 2 U2 26 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 1946-6234 EI 1946-6242 J9 SCI TRANSL MED JI Sci. Transl. Med. PD NOV 19 PY 2014 VL 6 IS 263 AR 263ra160 DI 10.1126/scitranslmed.3009980 PG 12 WC Cell Biology; Medicine, Research & Experimental SC Cell Biology; Research & Experimental Medicine GA AT8CD UT WOS:000345160500006 PM 25411473 ER PT J AU Talley, AK Healy, SA Finney, OC Murphy, SC Kublin, J Salas, CJ Lundebjerg, S Gilbert, P Van Voorhis, WC Whisler, J Wang, RB Ockenhouse, CF Heppner, DG Kappe, SH Duffy, PE AF Talley, Angela K. Healy, Sara A. Finney, Olivia C. Murphy, Sean C. Kublin, James Salas, Carola J. Lundebjerg, Susan Gilbert, Peter Van Voorhis, Wesley C. Whisler, John Wang, Ruobing Ockenhouse, Chris F. Heppner, D. Gray Kappe, Stefan H. Duffy, Patrick E. TI Safety and Comparability of Controlled Human Plasmodium falciparum Infection by Mosquito Bite in Malaria-Naive Subjects at a New Facility for Sporozoite Challenge SO PLOS ONE LA English DT Article ID TO-BLOOD INOCULA; HUMAN VOLUNTEERS; VACCINES; IMMUNITY; UPDATE; COHORT; VIVAX; CELLS; MODEL; RATES AB Background: Controlled human malaria infection (CHMI) studies which recapitulate mosquito-borne infection are a critical tool to identify protective vaccine and drug candidates for advancement to field trials. In partnership with the Walter Reed Army Institute of Research, the CHMI model was established at the Seattle Biomedical Research Institute's Malaria Clinical Trials Center (MCTC). Activities and reagents at both centers were aligned to ensure comparability and continued safety of the model. To demonstrate successful implementation, CHMI was performed in six healthy malaria-naive volunteers. Methods: All volunteers received NF54 strain Plasmodium falciparum by the bite of five infected Anopheles stephensi mosquitoes under controlled conditions and were monitored for signs and symptoms of malaria and for parasitemia by peripheral blood smear. Subjects were treated upon diagnosis with chloroquine by directly observed therapy. Immunological (T cell and antibody) and molecular diagnostic (real-time quantitative reverse transcriptase polymerase chain reaction [qRT-PCR]) assessments were also performed. Results: All six volunteers developed patent parasitemia and clinical malaria. No serious adverse events occurred during the study period or for six months post-infection. The mean prepatent period was 11.2 days (range 9-14 days), and geometric mean parasitemia upon diagnosis was 10.8 parasites/mu L (range 2-69) by microscopy. qRT-PCR detected parasites an average of 3.7 days (range 2-4 days) earlier than blood smears. All volunteers developed antibodies to the blood-stage antigen merozoite surface protein 1 (MSP-1), which persisted up to six months. Humoral and cellular responses to pre-erythrocytic antigens circumsporozoite protein (CSP) and liver-stage antigen 1 (LSA-1) were limited. Conclusion: The CHMI model was safe, well tolerated and characterized by consistent prepatent periods, pre-symptomatic diagnosis in 3/6 subjects and adverse event profiles as reported at established centers. The MCTC can now evaluate candidates in the increasingly diverse vaccine and drug pipeline using the CHMI model. C1 [Talley, Angela K.; Finney, Olivia C.; Lundebjerg, Susan; Whisler, John; Wang, Ruobing; Kappe, Stefan H.] Seattle Biomed Res Inst, Malaria Clin Trials Ctr, Seattle, WA 98109 USA. [Healy, Sara A.; Duffy, Patrick E.] NIAID, Lab Malaria Immunol & Vaccinol, NIH, Bethesda, MD 20892 USA. [Murphy, Sean C.] Univ Washington, Med Ctr, Dept Lab Med, Seattle, WA 98195 USA. [Kublin, James; Gilbert, Peter] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Salas, Carola J.] US Naval Med Res Unit 6, Lima, Peru. [Van Voorhis, Wesley C.] Univ Washington, Med Ctr, Dept Med, Seattle, WA 98195 USA. [Ockenhouse, Chris F.; Heppner, D. Gray] Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Silver Spring, MD USA. RP Duffy, PE (reprint author), NIAID, Lab Malaria Immunol & Vaccinol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. EM patrick.duffy@nih.gov FU PATH Malaria Vaccine Initiative (MVI); United States Department of Defense; Intramural Research Program of National Institute of Allergy and Infectious Diseases, National Institutes of Health; Global Emerging Infections Surveillance and Response System of the United States Department of Defense (AFHSC/GEIS) [847705.82000.256B.B0016] FX Funding for the initial MCTC infrastructure and for this clinical trial funding was provided by the PATH Malaria Vaccine Initiative (MVI) and the United States Department of Defense. MVI staff (Florence Kaltovich and Cynthia Lee) provided technical support on the chemistry, manufacturing, and control section of the IND application and the clinical operations aspects associated with this study, the latter through MVI's clinical quality assurance consultants at The Total Approach. C. F. O. is now employed by MVI/PATH and contributed to the review of the manuscript. This work was also supported by the Intramural Research Program of National Institute of Allergy and Infectious Diseases, National Institutes of Health (S. A. H., P. E. D.), and the Global Emerging Infections Surveillance and Response System of the United States Department of Defense (AFHSC/GEIS) under work unit number 847705.82000.256B.B0016 (C. J. S.). The authors have no conflicts that affect their adherence to all PLOS ONE policies on sharing data and materials. NR 27 TC 6 Z9 7 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 18 PY 2014 VL 9 IS 11 AR e109654 DI 10.1371/journal.pone.0109654 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AX7UZ UT WOS:000347121300006 PM 25405724 ER PT J AU Baker, DR Simmerman, RF Sumner, JJ Bruce, BD Lundgren, CA AF Baker, David R. Simmerman, Richard F. Sumner, James J. Bruce, Barry D. Lundgren, Cynthia A. TI Photoelectrochemistry of Photosystem I Bound in Nafion SO LANGMUIR LA English DT Article ID AMPEROMETRIC GLUCOSE SENSORS; REDOX POLYMER-FILMS; ENZYME ELECTRODES; REACTION CENTERS; OXIDASE; ELECTROCHEMISTRY; IMMOBILIZATION; PROTEINS; CELLS; POLYPYRROLE AB Developing a solid state Photosystem I (PSI) modified electrode is attractive for photoelectrochemical applications because of the quantum yield of PSI, which approaches unity in the visible spectrum. Electrodes are constructed using a Nafion film to encapsulate PSI as well as the hole-scavenging reox me PY diator Os(b) Cl The photoactive electrodes generate photo, currents of 4 mu A/cm2.+1,vhen illuminated with 1.4 mW/cm(2) of 676 nm band-pass' filtered light. Methyl viologen (MV4) is present in the electrolyte to scavenge photoelectrons from PSI in the Nafion film and transport charges to the counter electrode. Because MV2+ is positively charged in both reduced and oxidized states, it is able to diffuse through the cation permeable channels of Nafion. Photocurrent is produced when the working electrode is set to voltages negative of the 0s3+/Os2+ redox potential. Charge transfer through the Nafion film and photohole,scavenging at the PSI luminal surface by Os(bpy)(2) Cl-2 depends on the reduction of Os redox centers to Os2+ via hole scavenging from PSI. The optimal film densities of Nafion (10 pg/cm 2 Nafion) and PSI (100 trg/cm2 PSI), are determined to provide the highest photocurrents. These optimal film densities force films to be thin to allow the majority of PSI to have productive electrical contact with the backing electrode. C1 [Baker, David R.; Sumner, James J.; Lundgren, Cynthia A.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Simmerman, Richard F.; Bruce, Barry D.] Univ Tennessee, Dept Biochem & Cellular & Mol Biol, Knoxville, TN 37996 USA. RP Lundgren, CA (reprint author), 2800 Powder Mill Rd Adelphi, Adelphi, MD 20783 USA. EM cynthia.a.lundgren2.civ@mail.mil FU U.S. Department of the Army; U.S. Army Materiel Command; U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities; NSF-EPSCOR [EPS-1004083]; National Science Foundation IGERT program [DGE0801470]; Directors Strategic Initiative, "Understanding Photosystem I as a Biomolecular Reactor for Energy Conversion" at the Army Research Laboratory, Ade lphi, MD, USA [W911NF-11-2-0029] FX Financial support from the U.S. Department of the Army and U.S. Army Materiel Command are gratefully acknowledged.Research was supported, in part, by a contractual appointment to the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities (D.RB.). B.D.B. acknowledges support from TNSCORE, a multidisciplinary research program sponsored by NSF-EPSCOR (EPS-1004083), and support from the Gibson Family Foundation. R.F.S. was supported as an IGERT fellow from the National Science Foundation IGERT program (DGE0801470). We also acknowledge support from the Directors Strategic Initiative, "Understanding Photosystem I as a Biomolecular Reactor for Energy Conversion" at the Army Research Laboratory, Ade lphi, MD, USA (ARL Contract #W911NF-11-2-0029). NR 45 TC 8 Z9 8 U1 6 U2 56 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD NOV 18 PY 2014 VL 30 IS 45 BP 13650 EP 13655 DI 10.1021/la503132h PG 6 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA AT9RS UT WOS:000345264500019 PM 25341002 ER PT J AU Massaro, E Bagnoli, F AF Massaro, Emanuele Bagnoli, Franco TI Epidemic spreading and risk perception in multiplex networks: A self-organized percolation method SO PHYSICAL REVIEW E LA English DT Article ID INTERDEPENDENT NETWORKS; SOCIAL NETWORKS; EVOLUTION; WORLD AB In this paper we study the interplay between epidemic spreading and risk perception on multiplex networks. The basic idea is that the effective infection probability is affected by the perception of the risk of being infected, which we assume to be related to the fraction of infected neighbors, as introduced by Bagnoli et al. [Phys. Rev. E 76, 061904 (2007)]. We rederive previous results using a self-organized method that automatically gives the percolation threshold in just one simulation. We then extend the model to multiplex networks considering that people get infected by physical contacts in real life but often gather information from an information network, which may be quite different from the physical ones. The similarity between the physical and the information networks determines the possibility of stopping the infection for a sufficiently high precaution level: if the networks are too different, there is no means of avoiding the epidemics. C1 [Massaro, Emanuele] US Army Engineer Res & Dev Ctr, Risk & Decis Sci Team, Concord, MA 01742 USA. [Massaro, Emanuele] Carnegie Mellon Univ, Dept Civil & Environm Engn, Pittsburgh, PA 15213 USA. [Bagnoli, Franco] Univ Florence, Dipartimento Fis & Astron, I-50019 Florence, Italy. [Bagnoli, Franco] Univ Florence, CSDC, I-50019 Florence, Italy. [Bagnoli, Franco] Ist Nazl Fis Nucl, Sez Firenze, I-50019 Florence, Italy. RP Massaro, E (reprint author), US Army Engineer Res & Dev Ctr, Risk & Decis Sci Team, 696 Virginia Rd, Concord, MA 01742 USA. EM emassaro@andrew.cmu.edu; franco.bagnoli@unifi.it RI Bagnoli, Franco/K-6904-2015 OI Bagnoli, Franco/0000-0002-6293-0305 FU European Commission [ICT-20111.1.6, 288021, FP7-ICT-2013-10, 611299 SciCafe 2.0] FX The authors are grateful to Dr. Nicola Perra for helpful discussions. F. B. acknowledges partial financial support from European Commission (ICT-20111.1.6) Proposal No. 288021 EINS - Network of Excellence in Internet Science and European Commission (FP7-ICT-2013-10) Proposal No. 611299 SciCafe 2.0. NR 23 TC 17 Z9 19 U1 0 U2 19 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2470-0045 EI 2470-0053 J9 PHYS REV E JI Phys. Rev. E PD NOV 18 PY 2014 VL 90 IS 5 AR 052817 DI 10.1103/PhysRevE.90.052817 PG 8 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA AT9MN UT WOS:000345251500009 ER PT J AU Turalska, M West, BJ AF Turalska, M. West, B. J. TI Imitation versus payoff: Duality of the decision-making process demonstrates criticality and consensus formation SO PHYSICAL REVIEW E LA English DT Article ID EVOLUTIONARY GAMES; PRISONERS-DILEMMA; PROMOTE COOPERATION; BEHAVIOR AB We consider a dual model of decision making, in which an individual forms its opinion based on contrasting mechanisms of imitation and rational calculation. The decision-making model (DMM) implements imitating behavior by means of a network of coupled two-state master equations that undergoes a phase transition at a critical value of a control parameter. The evolutionary spatial game, being a generalization of the prisoner's dilemma game, is used to determine in objective fashion the cooperative or anticooperative strategy adopted by individuals. Interactions between two sources of dynamics increases the domain of initial states attracted to phase transition dynamics beyond that of the DMM network in isolation. Additionally, on average the influence of the DMM on the game increases the final observed fraction of cooperators in the system. C1 [Turalska, M.; West, B. J.] Duke Univ, Dept Phys, Durham, NC 27709 USA. [West, B. J.] US Army Res Off, Informat Sci Directorate, Res Triangle Pk, NC 27708 USA. RP Turalska, M (reprint author), Duke Univ, Dept Phys, Durham, NC 27709 USA. FU Army Research Office [W911NF-04-D-0001] FX The authors thank the Army Research Office for support of this research (Grant No. W911NF-04-D-0001). NR 35 TC 1 Z9 1 U1 0 U2 11 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2470-0045 EI 2470-0053 J9 PHYS REV E JI Phys. Rev. E PD NOV 18 PY 2014 VL 90 IS 5 AR 052815 DI 10.1103/PhysRevE.90.052815 PG 7 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA AT9MN UT WOS:000345251500007 ER PT J AU McWilliams, B Dibelka, J Yen, CF AF McWilliams, B. Dibelka, J. Yen, C. -F. TI Multi scale modeling and characterization of inelastic deformation mechanisms in continuous fiber and 2D woven fabric reinforced metal matrix composites SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Metal matrix composites (MMCs); Mechanical properties; Finite element method; Micromechanics; Cohesive zone modeling ID TENSILE-STRENGTH; FLOW-STRESS; ALUMINUM; DAMAGE; BEHAVIOR; EVOLUTION; FRACTURE; YIELD AB Continuous unidirectional ceramic fiber and woven fabric reinforced metal matrix composites (MMCs) have potential to obtain very high specific strengths and stiffnesses, but use in structural applications has thus far been limited by their inherently low ductility, particularly in tensile loading conditions. In this work, a multi-scale micromechanics based finite element framework is used to predict, and understand the effect of microstructure on the tensile deformation behavior, including progressive damage and failure, of ceramic fiber and fabric reinforced MMCs. A hierarchal approach is implemented in which a micro-scale model is used to determine the transversely isotropic elasto-plastic mechanical behavior of unidirectional fiber reinforced MMC based on the properties of an aluminum alloy matrix, individual ceramic fibers, and the fiber-matrix interface. The validated transversely isotropic constitutive behavior is then input into a unit cell model for a woven fabric MMC consisting of unidirectional MMC tows in an aluminum matrix. Parallel experimental tensile testing and characterization of fracture mechanisms are used to validate our model for unidirectional and 2D weave fabric MMC. Cohesive zones are used to model the interfacial properties at both scales and we are able to quantify the contribution of various deformation and damage mechanisms such as ductile matrix failure, interfacial decohesion, transverse plasticity, and axial fiber fracture to the overall mechanical response of the MMC. It was found that interfacial debonding contributes significantly to the inelastic response of unidirectional and woven fabric MMC and that experimental data are relatively well reproduced by a model that assumes a weak interfacial debonding cohesive law (maximum allowable interface stresses on the order of 100 MPa and total work of decohesion = 75 J/m(2)). Published by Elsevier B.V. C1 [McWilliams, B.; Yen, C. -F.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Dibelka, J.] Naval Surface Warfare Ctr, Carderock Div, West Bethesda, MD USA. RP McWilliams, B (reprint author), US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM brandon.a.mcwilliams.civ@mail.mil; jessica.a.dibelka.civ@mail.mil; chianfong.yen.civ@mail.mil NR 48 TC 3 Z9 3 U1 3 U2 24 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 EI 1873-4936 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD NOV 17 PY 2014 VL 618 BP 142 EP 152 DI 10.1016/j.msea.2014.08.063 PG 11 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA AS7MG UT WOS:000344439500018 ER PT J AU Adlakha, I Tschopp, MA Solanki, KN AF Adlakha, I. Tschopp, M. A. Solanki, K. N. TI The role of grain boundary structure and crystal orientation on crack growth asymmetry in aluminum SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Grain boundary; Twinning; Dislocation; Fracture; Directional anisotropy ID MOLECULAR-DYNAMICS SIMULATION; SYMMETRICAL TILT BOUNDARIES; CSL TWIST BOUNDARIES; DISLOCATION NUCLEATION; FCC METALS; DIRECTIONAL DEPENDENCE; COMPUTER-SIMULATION; COPPER/SAPPHIRE BICRYSTAL; NANOCRYSTALLINE MATERIALS; DEFORMATION-MECHANISM AB Atomistic simulations have shown that the grain boundary (GB) structure affects a number of physical, mechanical, thermal, and chemical properties, which can have a profound effect on macroscopic properties of polycrystalline materials. The research objective herein is to use atomistic simulations to explore the role that GB structure and the adjacent crystallographic orientations have on the directional asymmetry of an intergranular crack (i.e. cleavage behavior is favored along one direction, while ductile behavior along the other direction of the interface) for aluminum grain boundaries. Simulation results from seven [110] symmetric tilt grain boundaries (STGBs) show that the GB structure and the associated free volume directly influence the stress-strain response, crack growth rate, and crack tip plasticity mechanisms for middle-tension (M(T)) crack propagation specimens. In particular, the structural units present within the GB promote whether a dislocation or twinning-based mechanism operates at the crack tip during intergranular fracture along certain GBs (e.g., the 'E' structural unit promotes twinning at the crack tip in Al). Furthermore, the crystallography of the adjacent grains, and therefore the available slip planes, can significantly affect the crack growth rates in both directions of the crack - this creates a strong directional asymmetry in the crack growth rate in the Sigma 11 (113) and the Sigma 27 (552) STGBs. Upon comparing these results with the theoretical Rice criterion, it was found that certain GBs in this study (Sigma 9 (221), Sigma 11 (332) and Sigma 33 (441)) show an absence of directional asymmetry in the observed crack growth behavior, in conflict with the Rice criterion. The significance of the present research is that it provides a physical basis for the role of GB character and crystallographic orientation on intergranular crack tip deformation behavior. (C) 2014 Elsevier B.V. All rights reserved. C1 [Adlakha, I.; Solanki, K. N.] Arizona State Univ, Sch Engn Matter Transport & Energy, Tempe, AZ 85287 USA. [Tschopp, M. A.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Solanki, KN (reprint author), Arizona State Univ, Sch Engn Matter Transport & Energy, Tempe, AZ 85287 USA. EM kiran.solanki@asu.edu RI Solanki, Kiran/E-8337-2010; OI Adlakha, Ilaksh/0000-0002-2028-3357; Tschopp, Mark/0000-0001-8471-5035 FU Office of Naval Research [N000141110793] FX The authors would like to recognize Dr. W. Mullins and Dr. A.K. Vasudevan from the Office of Naval Research for providing insights and valuable suggestions. This material is based upon work supported by the Office of Naval Research under contract no. N000141110793. We would also like to acknowledge the Fulton High Performance Computing at Arizona State University. NR 78 TC 7 Z9 7 U1 5 U2 56 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 EI 1873-4936 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD NOV 17 PY 2014 VL 618 BP 345 EP 354 DI 10.1016/j.msea.2014.08.083 PG 10 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA AS7MG UT WOS:000344439500041 ER PT J AU Williams, CL Chen, CQ Ramesh, KT Dandekar, DP AF Williams, C. L. Chen, C. Q. Ramesh, K. T. Dandekar, D. P. TI On the shock stress, substructure evolution, and spall response of commercially pure 1100-O aluminum SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Shock stress; Shock hardening; Dynamic recovery; Substructure; Evolution; Recovery ID STRAIN RATE DEFORMATION; STAINLESS-STEEL; GRAIN-SIZE; MICROSTRUCTURES; BEHAVIOR; FAILURE; METALS; COPPER; NICKEL AB Plate impact shock and spall recovery experiments were conducted to study the effects of peak shock stress on the substructure evolution and spall response of fully annealed 1100 aluminum. The substructure of the material evolves substantially with increase in peak shock stress ranging from 4 GPa to 9 GPa with dislocation debris uniformly distributed throughout the interior of the subgrain. Observations from substructure evolution in conjunction with spall failure results suggest that ductile fracture by void nucleation, growth, and coalescence was perhaps the dominant fracture mode for shock stresses up to approximately 8.3 GPa. Whereas, beyond 8.3 GPa the material softened possibly due to dislocation reorganization (dynamic recovery) and brittle intergranular fracture by decohesion with isolated pockets of nanovoids was perhaps the dominant fracture mode. The contributions of nanovoids to the dynamic recovery process, if any, were unresolved. Microhardness measurements show an increase in residual hardness throughout the shock stress range studied implying shock hardening up to approximately 8.3 GPa. This observation also suggests that thermal softening was not operative throughout the shock stress range studied. However, dynamic recovery was thermally influenced during shock loading. Published by Elsevier B.V. C1 [Williams, C. L.; Dandekar, D. P.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Chen, C. Q.; Ramesh, K. T.] Johns Hopkins Univ, Baltimore, MD 21218 USA. RP Williams, CL (reprint author), US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM cyril.l.williams.civ@mail.mil FU United States Army Research Laboratory (ARL) at Aberdeen Proving Ground; Center for Advanced Metallic and Ceramic Systems (CAMCS) at The Johns Hopkins University under ARMAC-RTP [W911NF-06-2-0006] FX Funding for this research was provided by both the United States Army Research Laboratory (ARL) at Aberdeen Proving Ground and the Center for Advanced Metallic and Ceramic Systems (CAMCS) at The Johns Hopkins University under ARMAC-RTP Cooperative Agreement no. W911NF-06-2-0006. The authors wish to acknowledge Dr. George ''Rusty'' Gray III (Los Alamos National Laboratory) for his valuable technical suggestions with regards to the recovery experiments and Dr. John D. Clayton for reviewing the manuscript NR 55 TC 1 Z9 1 U1 2 U2 15 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 EI 1873-4936 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD NOV 17 PY 2014 VL 618 BP 596 EP 604 DI 10.1016/j.msea.2014.09.030 PG 9 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA AS7MG UT WOS:000344439500073 ER PT J AU Garg, K Corona, BT Walters, TJ AF Garg, Koyal Corona, Benjamin T. Walters, Thomas J. TI Losartan administration reduces fibrosis but hinders functional recovery after volumetric muscle loss injury SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE losartan; fibrosis; volumetric muscle loss; regeneration ID SPONTANEOUSLY HYPERTENSIVE-RATS; REVERSES MYOCARDIAL FIBROSIS; GROWTH-FACTOR-BETA; COLLAGEN TYPE-I; SKELETAL-MUSCLE; ANGIOTENSIN-II; TGF-BETA; INFLAMMATORY RESPONSE; MOLECULAR-MECHANISMS; ANTIFIBROSIS AGENT AB Losartan is a Food and Drug Administration approved antihypertensive medication that is recently emerging as an antifibrotic therapy. Previously, losartan has been successfully used to reduce fibrosis and improve both muscle regeneration and function in several models of recoverable skeletal muscle injuries, such as contusion and laceration. In this study, the efficacy of losartan treatment in reducing fibrosis and improving regeneration was determined in a Lewis rat model of volumetric muscle loss (VML) injury. VML has been defined as the traumatic or surgical loss of skeletal muscle with resultant functional impairment. It is among the top 10 causes for wounded service members to be medically retired from the military. This study shows that, after several weeks of recovery, VML injury results in little to no muscle regeneration, but is marked by persistent inflammation, chronic upregulation of profibrotic markers and extracellular matrix (i.e., collagen type I), and fat deposition at the defect site, which manifest irrecoverable deficits in force production. Losartan administration at 10 mg.kg(-1).day(-1) was able to modulate the gene expression of fibrotic markers and was also effective at reducing fibrosis (i.e., the deposition of collagen type I) in the injured muscle. However, there were no improvements in muscle regeneration, and deleterious effects on muscle function were observed instead. We propose that, in the absence of regeneration, reduction in fibrosis worsens the ability of the VML injured muscle to transmit forces, which ultimately results in decreased muscle function. C1 [Garg, Koyal; Corona, Benjamin T.; Walters, Thomas J.] US Army, Inst Surg Res Extrem Trauma & Regenerat Med, Ft Sam Houston, TX 78234 USA. RP Walters, TJ (reprint author), US Army, Inst Surg Res Extrem Trauma & Regenerat Med, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM thomas.j.walters22.civ@mail.mil FU Combat Casualty Care Research Program, Medical Research and Materiel Command FX These studies were funded by the Combat Casualty Care Research Program, Medical Research and Materiel Command. NR 57 TC 6 Z9 6 U1 2 U2 5 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 EI 1522-1601 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD NOV 15 PY 2014 VL 117 IS 10 BP 1120 EP 1131 DI 10.1152/japplphysiol.00689.2014 PG 12 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA AT9MW UT WOS:000345252300006 PM 25257876 ER PT J AU Koster, R Mitra, N D'Andrea, K Vardhanabhuti, S Chung, CC Wang, ZM Erickson, RL Vaughn, DJ Litchfield, K Rahman, N Greene, MH McGlynn, KA Turnbull, C Chanock, SJ Nathanson, KL Kanetsky, PA AF Koster, Roelof Mitra, Nandita D'Andrea, Kurt Vardhanabhuti, Saran Chung, Charles C. Wang, Zhaoming Erickson, R. Loren Vaughn, David J. Litchfield, Kevin Rahman, Nazneen Greene, Mark H. McGlynn, Katherine A. Turnbull, Clare Chanock, Stephen J. Nathanson, Katherine L. Kanetsky, Peter A. TI Pathway-based analysis of GWAs data identifies association of sex determination genes with susceptibility to testicular germ cell tumors SO HUMAN MOLECULAR GENETICS LA English DT Article ID GENOME-WIDE ASSOCIATION; CARCINOMA IN-SITU; TRANSCRIPTION FACTOR GATA-4; TESTIS DIFFERENTIATION; EXPRESSION PROFILES; ENRICHMENT ANALYSIS; MAMMALIAN TESTIS; DMRT1; CANCER; VARIANTS AB Genome-wide association (GWA) studies of testicular germ cell tumor (TGCT) have identified 18 susceptibility loci, some containing genes encoding proteins important in male germ cell development. Deletions of one of these genes, DMRT1, lead to male-to-female sex reversal and are associated with development of gonadoblastoma. To further explore genetic association with TGCT, we undertook a pathway-based analysis of SNP marker associations in the Penn GWAs (349 TGCT cases and 919 controls). We analyzed a custom-built sex determination gene set consisting of 32 genes using three different methods of pathway-based analysis. The sex determination gene set ranked highly compared with canonical gene sets, and it was associated with TGCT (FDRG(5) = 2.28 x 10(-5), FDRM = 0.014 and FDRI = 0.008 for Gene Set Analysis-SNP (GSA-SNP), Meta-Analysis Gene Set Enrichment of Variant Associations (MAGENTA) and Improved Gene Set Enrichment Analysis for Genomewide Association Study (i-GSEA4GWAS) analysis, respectively). The association remained after removal of DMRT1 from the gene set (FDRG = 0.0002, FDRM = 0.055 and FDRI = 0.009). Using data from the NCI GWA scan (582 TGCT cases and 1056 controls) and UK scan (986 TGCT cases and 4946 controls), we replicated these findings (NCI: FDRG = 0.006, FDRM = 0.014, FDRI = 0.033, and UK: FDRG = 1.04 x 10(-6), FDRM = 0.016, FDRI = 0.025). After removal of DMRT1 from the gene set, the sex determination gene set remains associated ith TGCT in the NCI (FDRG = 0.039, FDRM = 0.050 and FDRI = 0.055) and UK scans (FDRG = 3.00 x 10(-5), FDRM = 0.056 and FDRI = 0.044). With the exception of DMRT1, genes in the sex determination gene set have not previously been identified as TGCT susceptibility loci in these GWA scans, demonstrating the complementary nature of a pathway-based approach for genome-wide analysis of TGCT. C1 [Koster, Roelof; D'Andrea, Kurt; Nathanson, Katherine L.] Univ Penn, Perelman Sch Med, Dept Med, Philadelphia, PA 19104 USA. [Mitra, Nandita; Vardhanabhuti, Saran; Kanetsky, Peter A.] Univ Penn, Perelman Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA. [Vaughn, David J.] Univ Penn, Perelman Sch Med, Dept Med, Div Hematol Oncol, Philadelphia, PA 19104 USA. [Vaughn, David J.; Nathanson, Katherine L.; Kanetsky, Peter A.] Univ Penn, Perelman Sch Med, Abramson Canc Ctr, Philadelphia, PA 19104 USA. [Chung, Charles C.; Wang, Zhaoming; Greene, Mark H.; McGlynn, Katherine A.; Chanock, Stephen J.] NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, NIH, Bethesda, MD 20892 USA. [Wang, Zhaoming] NCI, Canc Genome Res Lab, Div Canc Epidemiol & Genet, SAIC Frederick Inc, Frederick, MD 21701 USA. [Erickson, R. Loren] Walter Reed Army Inst Res, Silver Spring, MD USA. [Litchfield, Kevin; Rahman, Nazneen; Turnbull, Clare] Inst Canc Res, Div Genet & Epidemiol, Sutton, Surrey, England. RP Kanetsky, PA (reprint author), H Lee Moffitt Canc Ctr & Res Inst, 12902 Magnolia Dr, Tampa, FL 33612 USA. EM peter.kanetsky@moffitt.org RI Koster, Roelof/E-2158-2016; Rahman, Nazneen/D-2802-2013 OI Koster, Roelof/0000-0003-1424-8579; Litchfield, Kevin/0000-0002-3725-0914; Rahman, Nazneen/0000-0003-4376-0440 FU Abramson Cancer Center at the University of Pennsylvania; US National Institutes of Health [R01CA114478]; NCI; Westat, Inc. [HHSN261200655004C]; Institute of Cancer Research, Cancer Research UK; Wellcome Trust FX The Penn GWAS (PENN) was supported by the Abramson Cancer Center at the University of Pennsylvania and US National Institutes of Health grant R01CA114478 to P. A. K. and K.L.N. The NCIGWAS work was supported by the Intramural Research Program of the NCI and by support services contract HHSN261200655004C with Westat, Inc. The UK testicular cancer study was supported by the Institute of Cancer Research, Cancer Research UK and the Wellcome Trust and made use of control data generated by the Wellcome Trust Case Control Consortium 2 (WTCCC2). NR 75 TC 11 Z9 12 U1 1 U2 11 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0964-6906 EI 1460-2083 J9 HUM MOL GENET JI Hum. Mol. Genet. PD NOV 15 PY 2014 VL 23 IS 22 BP 6061 EP 6068 DI 10.1093/hmg/ddu305 PG 8 WC Biochemistry & Molecular Biology; Genetics & Heredity SC Biochemistry & Molecular Biology; Genetics & Heredity GA AT1CY UT WOS:000344671900018 PM 24943593 ER PT J AU Sarney, WL Svensson, SP Anderson, EM Lundquist, AM Pearson, C Millunchick, JM AF Sarney, W. L. Svensson, S. P. Anderson, E. M. Lundquist, A. M. Pearson, C. Millunchick, J. M. TI The influence of growth temperature on Sb incorporation in InAsSb, and the temperature-dependent impact of Bi surfactants SO JOURNAL OF CRYSTAL GROWTH LA English DT Article DE Molecular beam epitaxy; Semiconducting III-V materials ID MOLECULAR-BEAM EPITAXY; BISMUTH; INSB; GAAS AB A series of two layer InAsSb films were grown with molecular beam epitaxy (MBE). We report the effect of substrate temperature on the composition of InAsSb grown with and without a Bi surfactant and find that the Sb incorporation is suppressed as the substrate temperature increases, and that it is also further suppressed by the presence of Bi at all temperatures. We examine the data with a kinetic model, which gives insights into the composition of mixed anion alloys using straightforward rate equations for each process that occurs during growth. It was shown that the reduction in Sb composition is due to the preferential removal of Bi by As, and that removal rate obeys an Arrhenius dependence with an activation energy of 1.35 eV. Published by Elsevier B.V. C1 [Sarney, W. L.; Svensson, S. P.] US Army, Res Lab, Adelphi, MD 20783 USA. [Anderson, E. M.; Lundquist, A. M.; Millunchick, J. M.] Univ Michigan, Dept Mat Sci & Engn, Ann Arbor, MI 48109 USA. [Pearson, C.] Univ Michigan, Dept Comp Sci Engn & Phys, Flint, MI 48502 USA. RP Sarney, WL (reprint author), US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM wendy.l.sarney.civ@mail.mil FU Department of Defense, Army Research Office [W911NF-12-1-0338] FX EMA, AML, CP, and JMM gratefully acknowledge Chakrapani Varanasi and the support of the Department of Defense, Army Research Office via the Grant number W911NF-12-1-0338. NR 15 TC 1 Z9 1 U1 4 U2 24 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0248 EI 1873-5002 J9 J CRYST GROWTH JI J. Cryst. Growth PD NOV 15 PY 2014 VL 406 BP 8 EP 11 DI 10.1016/j.jcrysgro.2014.07.048 PG 4 WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied SC Crystallography; Materials Science; Physics GA AQ8QC UT WOS:000343092800002 ER PT J AU Pike, AW Zuo, QH AF Pike, A. W. Zuo, Q. H. TI Geometric design consideration for controlled fragmentation of metallic shells SO FINITE ELEMENTS IN ANALYSIS AND DESIGN LA English DT Article DE Controlled fragmentation; Natural fragmentation; CTH simulations; Geometric consideration; Johnson-Cook failure model; Explosive loading ID PHYSICS AB Geometric designs for the controlled fragmentation of metal cylindrical shells have been considered via CTH hydrocode simulations. Fragmentation is controlled by engineering notches on the interior of the shells. Design parameters considered include the shell radius, thickness, and the depth and spacing of interior notches. A large number of shell designs were analyzed and their effectiveness on the controlled fragmentation categorized. The best overall controlled fragmentation designs exhibit full and complete fragment breakup as prescribed along the system of interior notches without any of the individual fragments naturally fragmenting throughout their thicknesses. For the combination of the Composition C-4 explosive and the 4340 steel, the best performing designs were shown to commonly possess the Following characteristics: (1) they each have notch or groove depths greater than half of the shell thickness. (2) they each have notch or groove spacing within a range that is approximately the same as the shell thickness, and (3) they each have shell thicknesses many times smaller than the shell radius. (C) 2014 Elsevier B.V. All rights reserved. C1 [Pike, A. W.; Zuo, Q. H.] Univ Alabama, Dept Mech & Aerosp Engn, Huntsville, AL 35899 USA. [Pike, A. W.] US Army, AMRDEC, Redstone Arsenal, AL 35898 USA. RP Zuo, QH (reprint author), Univ Alabama, Dept Mech & Aerosp Engn, Huntsville, AL 35899 USA. EM zuo@eng.uah.edu FU US Army's Aviation and Missile Research, Development, and Engineering Center (AMRDEC); University of Alabama in Huntsville FX The authors would like to thank J. Gilbert, A. Kissell, B, J. Smith, G. Tackett, and D. Wallace for their guidance and support. the work was supported in part by the US Army's Aviation and Missile Research, Development, and Engineering Center (AMRDEC) and a research startup fund from the University of Alabama in Huntsville. The authors are grateful to two reviewers for their comments and suggestions which resulted in a number of improvements of the manuscript. NR 18 TC 2 Z9 3 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-874X EI 1872-6925 J9 FINITE ELEM ANAL DES JI Finite Elem. Anal. Des. PD NOV 15 PY 2014 VL 91 BP 59 EP 67 DI 10.1016/j.finel.2014.07.012 PG 9 WC Mathematics, Applied; Mechanics SC Mathematics; Mechanics GA AO4KW UT WOS:000341307800006 ER PT J AU Song, HS Reifman, J Wallqvist, A AF Song, Hyun-Seob Reifman, Jaques Wallqvist, Anders TI Prediction of Metabolic Flux Distribution from Gene Expression Data Based on the Flux Minimization Principle SO PLOS ONE LA English DT Article ID ESCHERICHIA-COLI; SACCHAROMYCES-CEREVISIAE; BALANCE ANALYSIS; SYSTEMS BIOLOGY; HIGH-THROUGHPUT; DRUG TARGETS; MODELS; NETWORKS; RECONSTRUCTIONS; BIOMARKERS AB Prediction of possible flux distributions in a metabolic network provides detailed phenotypic information that links metabolism to cellular physiology. To estimate metabolic steady-state fluxes, the most common approach is to solve a set of macroscopic mass balance equations subjected to stoichiometric constraints while attempting to optimize an assumed optimal objective function. This assumption is justifiable in specific cases but may be invalid when tested across different conditions, cell populations, or other organisms. With an aim to providing a more consistent and reliable prediction of flux distributions over a wide range of conditions, in this article we propose a framework that uses the flux minimization principle to predict active metabolic pathways from mRNA expression data. The proposed algorithm minimizes a weighted sum of flux magnitudes, while biomass production can be bounded to fit an ample range from very low to very high values according to the analyzed context. We have formulated the flux weights as a function of the corresponding enzyme reaction's gene expression value, enabling the creation of context-specific fluxes based on a generic metabolic network. In case studies of wild-type Saccharomyces cerevisiae, and wild-type and mutant Escherichia coli strains, our method achieved high prediction accuracy, as gauged by correlation coefficients and sums of squared error, with respect to the experimentally measured values. In contrast to other approaches, our method was able to provide quantitative predictions for both model organisms under a variety of conditions. Our approach requires no prior knowledge or assumption of a context-specific metabolic functionality and does not require trial-and-error parameter adjustments. Thus, our framework is of general applicability for modeling the transcription-dependent metabolism of bacteria and yeasts. C1 [Song, Hyun-Seob; Reifman, Jaques; Wallqvist, Anders] US Army Med Res & Mat Command, Dept Def, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. RP Wallqvist, A (reprint author), US Army Med Res & Mat Command, Dept Def, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. EM awallqvist@bhsai.org OI wallqvist, anders/0000-0002-9775-7469 FU U.S. Army Network Science Initiative FX This work was funded as part of the U.S. Army Network Science Initiative. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 41 TC 5 Z9 5 U1 1 U2 12 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 14 PY 2014 VL 9 IS 11 AR e112524 DI 10.1371/journal.pone.0112524 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AU4DF UT WOS:000345558500057 PM 25397773 ER PT J AU Sliozberg, Y Chantawansri, T AF Sliozberg, Yelena Chantawansri, Tanya TI Damage in spherical cellular membrane generated by the shock waves: Coarse-grained molecular dynamics simulation of lipid vesicle SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID DISSIPATIVE PARTICLE DYNAMICS; TRAUMATIC BRAIN-INJURY; MESOSCOPIC SIMULATION; NEURONAL INJURY; IN-VITRO; PRESSURE; BILAYERS; PERMEABILITY; LITHOTRIPSY; MORPHOLOGY AB Traumatic Brain Injury is a major health issue that is hard to diagnose since it often occurs without signs of external injuries. While it is well known that exposure of biological cells to shock waves causes damage to the cell membrane, it is currently unknown by which mechanisms damage is caused, and how it depends on physical parameters such as shock wave velocity, shock pulse duration, or shock pulse shape. In this computational study, we use a coarse-grained model of the lipid vesicle as a generic model of a cell membrane to elucidate the general principles of the cellular damage induced by the shock wave direct passage through the cranium. Results indicate that the extent of the liposome compression does not strongly depend on the pressure pulse and that liposome extension is very sensitive to the change in the negative pressure phase. The structural integrity of the vesicle is altered as pores form in the lipid membrane at overall pressure impulses generated by supersonic shock waves, which are greater than 5 Pa . s at single or repetitive exposure. Consequently, these permeability changes may lead to changes in the influx of sodium, potassium, and calcium ions. (C) 2014 AIP Publishing LLC. C1 [Sliozberg, Yelena] US Army Res Lab, TKC Global, Aberdeen Proving Ground, MD 21005 USA. [Chantawansri, Tanya] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Sliozberg, Y (reprint author), US Army Res Lab, TKC Global, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. FU U.S. Army Research Laboratory [W911QX-14-C-0016] FX The research reported in this document was performed in connection with contract/instrument W911QX-14-C-0016 with the U.S. Army Research Laboratory. NR 53 TC 4 Z9 4 U1 3 U2 18 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 EI 1089-7690 J9 J CHEM PHYS JI J. Chem. Phys. PD NOV 14 PY 2014 VL 141 IS 18 AR 184904 DI 10.1063/1.4901130 PG 10 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA AT3PZ UT WOS:000344847600038 PM 25399159 ER PT J AU Arnold, BR Roberson, SD Pellegrino, PM AF Arnold, Bradley R. Roberson, Stephen D. Pellegrino, Paul M. TI Repopulation of Nitrogen Excited Triplet State Following Laser-Induced Filamentation SO JOURNAL OF PHYSICAL CHEMISTRY A LA English DT Article ID ELECTRIC-FIELD STRENGTH; EMISSION-SPECTROSCOPY; ATMOSPHERIC-PRESSURE; INTENSITY RATIO; SPECTRAL BANDS; MOLECULAR NITROGEN; RADIATIVE LIFETIME; METASTABLE STATES; IMPACT EXCITATION; C3PIU STATE AB Laser-induced filamentation was used to study the dynamics of excited molecular nitrogen decay processes. It is well-known that upper excited nitrogen triplet states can be repopulated at time delays far longer than their fluorescence lifetimes. Examination of the time-resolved emission from several different species indicates that there are two major mechanisms acting to repopulate the N-2((CIIu)-I-3) excited state. The results implicate dissociative electron recombination with the nitrogen cation dimer, N-4(+), and energy pooling between two N-2(A(u)(3 Sigma)(+)) triplet states as the main pathways to repopulate the emissive upper triplet state. The densities of N-2(A(3)Sigma(+)(u)) and free electrons produced during filamentation were measured under atmospheric pressures in nitrogen and estimated to be [N-2(A(3)Sigma(+)(u))](0) = 3 X 10(15) cm(-3) and [e](0) = 3 X 10(13) cm(-3). The methods outlined in this report could find significant utility in measuring the concentration profiles of these important reactive intermediates within laser-induced filaments produced under different conditions. C1 [Arnold, Bradley R.; Roberson, Stephen D.; Pellegrino, Paul M.] US Army Res Lab, RDRL SEE O, Adelphi, MD 20783 USA. [Arnold, Bradley R.] Univ Maryland Baltimore Cty, Dept Chem & Biochem, Baltimore, MD 21250 USA. RP Arnold, BR (reprint author), US Army Res Lab, RDRL SEE O, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM barnold@umbc.edu FU MPCA; RDECOM-ARL: Army Research Laboratory under U.S. Army Research Office Scientific Services Program [0979, W911NF-07-D-0001]; Department of Chemistry and Biochemistry at UMBC FX The authors wish to acknowledge the MPCA for partial support of this research. BRA further acknowledges support by the RDECOM-ARL: Army Research Laboratory under the auspices of the U.S. Army Research Office Scientific Services Program administered by Battelle (Delivery Order 0979, Contract No. W911NF-07-D-0001) and the Department of Chemistry and Biochemistry at UMBC. NR 53 TC 0 Z9 0 U1 2 U2 17 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1089-5639 J9 J PHYS CHEM A JI J. Phys. Chem. A PD NOV 13 PY 2014 VL 118 IS 45 BP 10456 EP 10463 DI 10.1021/jp504237p PG 8 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA AT5IK UT WOS:000344976900020 PM 24991979 ER PT J AU Lakhashe, SK Byrareddy, SN Zhou, MK Bachler, BC Hemashettar, G Hu, SL Villinger, F Else, JG Stock, S Lee, SJ Vargas-Inchaustegui, DA Cofano, EB Robert-Guroff, M Johnson, WE Polonis, VR Forthal, DN Loret, EP Rasmussen, RA Ruprecht, RM AF Lakhashe, Samir K. Byrareddy, Siddappa N. Zhou, Mingkui Bachler, Barbara C. Hemashettar, Girish Hu, Shiu-Lok Villinger, Francois Else, James G. Stock, Shannon Lee, Sandra J. Vargas-Inchaustegui, Diego A. Cofano, Egidio Brocca Robert-Guroff, Marjorie Johnson, Welkin E. Polonis, Victoria R. Forthal, Donald N. Loret, Erwann P. Rasmussen, Robert A. Ruprecht, Ruth M. TI Multimodality vaccination against clade C SHIV: Partial protection against mucosal challenges with a heterologous tier 2 virus SO VACCINE LA English DT Article DE HIV vaccine; SHIV-C; Heterologous tier 2 virus; Rhesus monkey; Cellular immunity; ADCC ID SIMIAN IMMUNODEFICIENCY VIRUS; OVERLAPPING SYNTHETIC PEPTIDES; HIGHLY PATHOGENIC SIV; RHESUS MACAQUES; NEUTRALIZING ANTIBODIES; REPLICATION-COMPETENT; MOLECULAR CLONES; HIV-1 INFECTION; TAT VARIANTS; EFFICACY AB We sought to test whether vaccine-induced immune responses could protect rhesus macaques (RMs) against upfront heterologous challenges with an R5 simian-human immunodeficiency virus, SHIV-2873Nip. This SHIV strain exhibits many properties of transmitted HIV-1, such as tier 2 phenotype (relatively difficult to neutralize), exclusive CCR5 tropism, and gradual disease progression in infected RMs. Since no human AIDS vaccine recipient is likely to encounter an HIV-1 strain that exactly matches the immunogens, we immunized the RMs with recombinant Env proteins heterologous to the challenge virus. For induction of immune responses against Gag, Tat, and Nef, we explored a strategy of immunization with overlapping synthetic peptides (OSP). The immune responses against Gag and Tat were finally boosted with recombinant proteins. The vaccinees and a group of ten control animals were given five low-dose intrarectal (i.r.) challenges with SHIV-2873 Nip. All controls and seven out of eight vaccinees became systemically infected; there was no significant difference in viremia levels of vaccinees vs. controls. Prevention of viremia was observed in one vaccinee which showed strong boosting of virus-specific cellular immunity during virus exposures. The protected animal showed no challenge virus-specific neutralizing antibodies in the TZM-bl or A3R5 cell-based assays and had low-level ADCC activity after the virus exposures. Microarray data strongly supported a role for cellular immunity in the protected animal. Our study represents a case of protection against heterologous tier 2 SHIV-C by vaccine-induced, virus-specific cellular immune responses. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Lakhashe, Samir K.; Zhou, Mingkui; Ruprecht, Ruth M.] Texas Biomed Res Inst, San Antonio, TX 78245 USA. [Ruprecht, Ruth M.] Southwest Natl Primate Res Ctr, San Antonio, TX USA. [Lakhashe, Samir K.; Byrareddy, Siddappa N.; Zhou, Mingkui; Bachler, Barbara C.; Hemashettar, Girish; Stock, Shannon; Lee, Sandra J.; Rasmussen, Robert A.; Ruprecht, Ruth M.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Lakhashe, Samir K.; Byrareddy, Siddappa N.; Zhou, Mingkui; Lee, Sandra J.; Rasmussen, Robert A.; Ruprecht, Ruth M.] Harvard Univ, Sch Med, Boston, MA USA. [Hu, Shiu-Lok] Univ Washington, Seattle, WA 98195 USA. [Byrareddy, Siddappa N.; Villinger, Francois; Else, James G.] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA. [Villinger, Francois; Else, James G.] Emory Univ, Yerkes Natl Primate Res Ctr, Atlanta, GA 30322 USA. [Vargas-Inchaustegui, Diego A.; Cofano, Egidio Brocca; Robert-Guroff, Marjorie] NCI, Vaccine Branch, NIH, Bethesda, MD 20892 USA. [Johnson, Welkin E.] Boston Coll, Dept Biol, Chestnut Hill, MA 02167 USA. [Polonis, Victoria R.] Walter Reed Army Inst Res, Mil HIV Res Program, Silver Spring, MD USA. [Forthal, Donald N.] Univ Calif Irvine, Irvine Sch Med, Dept Med, Div Infect Dis, Irvine, CA USA. [Loret, Erwann P.] Aix Marseille Univ, CNRS, Fac Pharm, ETRAV Lab, F-13385 Marseille 5, France. RP Ruprecht, RM (reprint author), Texas Biomed Res Inst, POB 760549, San Antonio, TX 78245 USA. EM rruprecht@txbiomed.org FU NIH [R01 AI100703, P01 AI048240, AI095092]; Intramural Research Program of the NIH, National Cancer Institute; Office of Research Infrastructure Programs [OD P51 OD011132, OD P51 OD011133]; NCRR [P51 RR13986] FX We thank Stephanie Ehnert, Chris Souder and Kalpana Patel from the YNPRC for assistance with the primate studies. We acknowledge ABL, Inc. for the production of the clade C gp145 protein. This work was supported by NIH grants R01 AI100703 to RMR and P01 AI048240 to RMR, SLH, RAR and JLE. This project was also funded in part by the Intramural Research Program of the NIH, National Cancer Institute and by the Office of Research Infrastructure Programs/OD P51 OD011132 to the YNPRC and OD P51 OD011133 (previously NCRR grant P51 RR13986) to the Southwest National Primate Research Center. The work conducted by WEJ was supported by NIH grant AI095092. NR 64 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD NOV 12 PY 2014 VL 32 IS 48 BP 6527 EP 6536 DI 10.1016/j.vaccine.2014.08.065 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA AU2SY UT WOS:000345469000032 PM 25245933 ER PT J AU Zander, NE Dong, H Steele, J Grant, JT AF Zander, Nicole E. Dong, Hong Steele, Joshua Grant, John T. TI Metal Cation Cross-Linked Nanocellulose Hydrogels as Tissue Engineering Substrates SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE nanocellulose; tissue engineering; fibroblasts; fibronectin; XPS; FTIR ID NATIVE CELLULOSE; SCAFFOLDS; NANOTECHNOLOGY; PROLIFERATION; FIBRONECTIN; BIOACTIVITY; ADSORPTION; EXTRACTION; ATTACHMENT; NANOFIBERS AB The use of cellulose materials for biomedical applications is attractive due to their low cost, biocompatibility, and biodegradability. Specific processing of cellulose to yield nanofibrils further improves mechanical properties and suitability as a tissue engineering substrate due to the similarity to the fibrous structure, porosity, and size-scale of the native extracellular matrix. In order to generate the substrate, nanocellulose hydrogels were fabricated from carboxylated cellulose nanofibrils via hydrogelation using metal salts. Hydrogels cross-linked with Ca2+ and Fe3+ were investigated as tissue culture substrates for C3H10T1/2 fibroblast cells. Control substrates as well as those with physically adsorbed and covalently attached fibronectin protein were evaluated with X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR), and enzyme linked immunosorbent assay (ELISA). Significantly more cells were attached to surfaces modified with protein, with the highest number of cells adhered to the calcium cross-linked hydrogels with covalently attached protein. C1 [Zander, Nicole E.; Dong, Hong; Steele, Joshua] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Dong, Hong] Bowhead Sci & Technol LLC, Belcamp, MD 21017 USA. [Grant, John T.] Univ Dayton, Res Inst, Dayton, OH 45324 USA. RP Zander, NE (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM nicole.e.zander.civ@mail.mil NR 34 TC 10 Z9 10 U1 9 U2 47 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD NOV 12 PY 2014 VL 6 IS 21 BP 18502 EP 18510 DI 10.1021/am506007z PG 9 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA AT5IY UT WOS:000344978200021 PM 25295848 ER PT J AU Matsumoto, M Lee, SJ Waters, ML Gagne, MR AF Matsumoto, Masaomi Lee, Stephen J. Waters, Marcey L. Gagne, Michel R. TI A Catalyst Selection Protocol That Identifies Biomimetic Motifs from beta-Hairpin Libraries SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY LA English DT Article ID HISTIDINE-ASPARTATE COUPLE; GENERAL-ACID CATALYSIS; BARRIER HYDROGEN-BOND; SERINE PROTEASES; ACYL-TRANSFER; AROMATIC INTERACTIONS; ACTIVE-SITE; COMBINATORIAL APPROACH; ASYMMETRIC CATALYSIS; ESTER HYDROLYSIS AB Assaying a solid-phase library of histidine-containing beta-hairpin peptides by a reactive tagging scheme in organic solvents selects for catalysts that reproduce the strategies used by His-based enzyme active sites to accelerate acyl- and phosphonyl-transfer reactions. Rate accelerations (k(rel)) in organic solvents of up to 2.4 x 10(8) are observed. C1 [Matsumoto, Masaomi; Waters, Marcey L.; Gagne, Michel R.] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA. [Lee, Stephen J.] US Army, Res Off, Res Triangle Pk, NC 27709 USA. RP Waters, ML (reprint author), Univ N Carolina, Dept Chem, CB 3290, Chapel Hill, NC 27599 USA. EM mlwaters@unc.edu; mgagne@unc.edu FU Defense Threat Reduction Agency [HDTRA1-10-1-0030]; Army Research Office; NRC FX For financial support, M.R.G. and M.L.W. acknowledge the Defense Threat Reduction Agency (HDTRA1-10-1-0030), S.J.L. acknowledges the Army Research Office, and M.M. acknowledges a postdoctoral fellowship from the NRC. NR 52 TC 10 Z9 10 U1 2 U2 35 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0002-7863 J9 J AM CHEM SOC JI J. Am. Chem. Soc. PD NOV 12 PY 2014 VL 136 IS 45 BP 15817 EP 15820 DI 10.1021/ja503012g PG 4 WC Chemistry, Multidisciplinary SC Chemistry GA AT4JQ UT WOS:000344906100003 PM 25347708 ER PT J AU Jaiswal, A Tian, LM Tadepalli, S Liu, KK Fei, M Farrell, ME Pellegrino, PM Singamaneni, S AF Jaiswal, Amit Tian, Limei Tadepalli, Sirimuvva Liu, Keng-ku Fei, Max Farrell, Mikella E. Pellegrino, Paul M. Singamaneni, Srikanth TI Plasmonic Nanorattles with Intrinsic Electromagnetic Hot-Spots for Surface Enhanced Raman Scattering SO SMALL LA English DT Article ID GOLD NANO-OCTAHEDRA; METALLIC NANOPARTICLES; NANOSPHERE LITHOGRAPHY; CHEMICAL-DETECTION; CLUSTER ARRAYS; SERS; SPECTROSCOPY; PAPER; NANOSTRUCTURES; RESONANCE C1 [Jaiswal, Amit; Tian, Limei; Tadepalli, Sirimuvva; Liu, Keng-ku; Fei, Max; Singamaneni, Srikanth] Washington Univ, Inst Mat Sci & Engn, Dept Mech Engn & Mat Sci, St Louis, MO 63130 USA. [Farrell, Mikella E.; Pellegrino, Paul M.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Singamaneni, S (reprint author), Washington Univ, Inst Mat Sci & Engn, Dept Mech Engn & Mat Sci, St Louis, MO 63130 USA. EM singamaneni@wustl.edu OI Tadepalli, Sirimuvva/0000-0001-9658-9988 FU Army Research Office (ARO); Army Research Lab (ARL) [W911NF-11-2-0091]; National Science Foundation [CBET-1254399] FX A.J. and L.T. contributed equally to this work. The work was supported by Army Research Office (ARO) and Army Research Lab (ARL) under Contract No. W911NF-11-2-0091 and National Science Foundation under CBET-1254399. The authors thank Nano Research Facility (NRF), a member of the National Nanotechnology Infrastructure Network (NNIN), for providing access to electron microscopy facilities. NR 50 TC 19 Z9 19 U1 3 U2 64 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 1613-6810 EI 1613-6829 J9 SMALL JI Small PD NOV 12 PY 2014 VL 10 IS 21 BP 4287 EP 4292 DI 10.1002/smll.201401278 PG 6 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA AT4IT UT WOS:000344903500009 PM 25045064 ER PT J AU Khavrutskii, IV Legler, PM Friedlander, AM Wallqvist, A AF Khavrutskii, Ilja V. Legler, Patricia M. Friedlander, Arthur M. Wallqvist, Anders TI A Reaction Path Study of the Catalysis and Inhibition of the Bacillus anthracis CapD gamma-Glutamyl Transpeptidase SO BIOCHEMISTRY LA English DT Article ID TERMINAL NUCLEOPHILE HYDROLASE; SUBSTRATE-ASSISTED CATALYSIS; PENICILLIN ACYLASE; CRYSTAL-STRUCTURES; ESCHERICHIA-COLI; QUANTUM-MECHANICS; LETHAL TOXIN; ENZYME; CAPSULE; ONIOM AB The CapD enzyme of Bacillus anthracis is a gamma-glutamyl transpeptidase from the N-terminal nucleophile hydrolase superfamily that covalently anchors the poly-gamma-d-glutamic acid (pDGA) capsule to the peptidoglycan. The capsule hinders phagocytosis of B. anthracis by host cells and is essential for virulence. The role CapD plays in capsule anchoring and remodeling makes the enzyme a promising target for anthrax medical countermeasures. Although the structure of CapD is known, and a covalent inhibitor, capsidin, has been identified, the mechanisms of CapD catalysis and inhibition are poorly understood. Here, we used a computational approach to map out the reaction steps involved in CapD catalysis and inhibition. We found that the rate-limiting step of either CapD catalysis or inhibition was a concerted asynchronous formation of the tetrahedral intermediate with a barrier of 22-23 kcal/mol. However, the mechanisms of these reactions differed for the two amides. The formation of the tetrahedral intermediate with pDGA was substrate-assisted with two proton transfers. In contrast, capsidin formed the tetrahedral intermediate in a conventional way with one proton transfer. Interestingly, capsidin coupled a conformational change in the catalytic residue of the tetrahedral intermediate to stretching of the scissile amide bond. Furthermore, capsidin took advantage of iminol-amide tautomerism of its diacetamide moiety to convert the tetrahedral intermediate to the acetylated CapD. As evidence of the promiscuous nature of CapD, the enzyme cleaved the amide bond of capsidin by attacking it on the opposite side compared to pDGA. C1 [Khavrutskii, Ilja V.; Wallqvist, Anders] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Dept Def Biotechnol High Performance Comp Softwar, Ft Detrick, MD 21702 USA. [Legler, Patricia M.] Naval Res Labs, Ctr Biomol Sci & Engn, Washington, DC 20375 USA. [Friedlander, Arthur M.] US Army Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Khavrutskii, IV (reprint author), US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Dept Def Biotechnol High Performance Comp Softwar, Ft Detrick, MD 21702 USA. EM ikhavrutskii@bhsai.org FU Defense Threat Reduction Agency [CBM.THERB.02.11.RD.012] FX This work was sponsored by Defense Threat Reduction Agency Grant CBM.THERB.02.11.RD.012. NR 56 TC 3 Z9 3 U1 2 U2 28 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0006-2960 J9 BIOCHEMISTRY-US JI Biochemistry PD NOV 11 PY 2014 VL 53 IS 44 BP 6954 EP 6967 DI 10.1021/bi500623c PG 14 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA AT4JJ UT WOS:000344905400011 PM 25334088 ER PT J AU Golecki, HM Yuan, HY Glavin, C Potter, B Badrossamay, MR Goss, JA Phillips, MD Parker, KK AF Golecki, Holly McIlwee Yuan, Hongyan Glavin, Calla Potter, Benjamin Badrossamay, Mohammad R. Goss, Josue A. Phillips, Michael D. Parker, Kevin Kit TI Effect of Solvent Evaporation on Fiber Morphology in Rotary Jet Spinning SO LANGMUIR LA English DT Article ID NANOFIBERS; MODEL; DIAMETER; DEVICES AB The bulk production of polymeric nanofibers is important for fabricating high-performance, nanoscale materials. Rotary jet spinning (RJS) enables the mass production of nanostructured fibers by centrifugal forces but may result in inconsistent surface morphologies. Because nanofiber performance is dependent upon its surface features, we asked which parameters must be optimized during production to control fiber morphology. We developed and tested a mathematical model that describes how the competition between fluid instability and solvent removal in RJS regulates the degree of beading in fibers. Our data suggest that solvent evaporation during the spinning process causes an increase in jet viscosity and that these changes inhibit both bead formation and jet thinning. The RJS was used to vary experimental parameters, showing that fiber beading can be reduced by increasing solvent volatility, solution viscosity, and spinning velocity. Collectively, our results demonstrate that nanofiber morphology and diameter can be precisely controlled during RJS manufacturing. C1 [Golecki, Holly McIlwee; Yuan, Hongyan; Glavin, Calla; Potter, Benjamin; Badrossamay, Mohammad R.; Goss, Josue A.; Phillips, Michael D.; Parker, Kevin Kit] Harvard Univ, Dis Biophys Grp, Wyss Inst Biol Inspired Engn, Sch Engn & Appl Sci, Cambridge, MA 02138 USA. [Glavin, Calla; Potter, Benjamin; Phillips, Michael D.; Parker, Kevin Kit] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. RP Parker, KK (reprint author), Harvard Univ, Dis Biophys Grp, Wyss Inst Biol Inspired Engn, Sch Engn & Appl Sci, Cambridge, MA 02138 USA. EM kkparker@seas.harvard.edu FU Wyss Institute for Biologically Inspired Engineering, Harvard University Materials Research Science and Engineering Center (MRSEC); Harvard University Nanoscale Science and Engineering Center (NSEC); Harvard Center for Nanoscale Systems (CNS); National Science Foundation Graduate Research Fellowship Program FX The authors acknowledge L. Mahadevan for helpful discussions. The authors thank Leila F. Deravi and Alexander P. Nesmith for reviewing the manuscript. The authors acknowledge financial support of this work from Wyss Institute for Biologically Inspired Engineering, Harvard University Materials Research Science and Engineering Center (MRSEC), Harvard University Nanoscale Science and Engineering Center (NSEC), and Harvard Center for Nanoscale Systems (CNS). Holly McIlwee Golecki acknowledges the National Science Foundation Graduate Research Fellowship Program. NR 25 TC 12 Z9 12 U1 2 U2 37 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD NOV 11 PY 2014 VL 30 IS 44 BP 13369 EP 13374 DI 10.1021/la5023104 PG 6 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA AT4JG UT WOS:000344905100029 PM 25353398 ER PT J AU Campione, S de Ceglia, D Guclu, C Vincenti, MA Scalora, M Capolino, F AF Campione, Salvatore de Ceglia, Domenico Guclu, Caner Vincenti, Maria A. Scalora, Michael Capolino, Filippo TI Fano collective resonance as complex mode in a two-dimensional planar metasurface of plasmonic nanoparticles SO APPLIED PHYSICS LETTERS LA English DT Article ID LEAKY MODES; NANOCLUSTERS; NANOSPHERES; CLUSTERS AB Fano resonances are features in transmissivity/reflectivity/absorption that owe their origin to the interaction between a broad bright resonance and a dark (i.e., sub-radiant) narrower one. They may emerge in the optical properties of planar two-dimensional (2D) periodic arrays (metasurfaces) of plasmonic nanoparticles. In this letter, we provide a thorough assessment of their nature for the general case of normal and oblique plane wave incidence, highlighting when a Fano resonance is affected by the mutual coupling in an array and its capability to support free modal solutions. We analyze the representative case of a metasurface of plasmonic nanoshells at ultraviolet frequencies and compute its absorption under TE- and TM-polarized, oblique plane-wave incidence. In particular, we find that plasmonic metasurfaces display two distinct types of resonances observable as absorption peaks: one is related to the Mie electric dipolar resonance of each nanoparticle and the other is due to the forced excitation of free modes with small attenuation constant, usually found at oblique incidence. The latter is thus an array-induced collective Fano resonance. This realization opens up to manifold flexible designs at optical frequencies mixing individual and collective resonances. We explain the physical origin of such Fano resonances using the modal analysis through which we calculate the free modes with complex wavenumber supported by the metasurface. We define equivalent array dipolar polarizabilities that are directly related to the absorption physics at oblique incidence and show a direct dependence between array modal phase and attenuation constants and Fano resonances. We thus provide a more complete picture of Fano resonances that may lead to the design of filters, energy-harvesting devices, photodetectors, and sensors at ultraviolet frequencies. Similar resonances may be also extended to the visible range with an appropriate choice of geometries and materials. (C) 2014 AIP Publishing LLC. C1 [Campione, Salvatore; Guclu, Caner; Capolino, Filippo] Univ Calif Irvine, Dept Elect Engn & Comp Sci, Irvine, CA 92697 USA. [de Ceglia, Domenico; Vincenti, Maria A.] Natl Res Council AMRDEC, Charles M Bowden Res Lab, Redstone Arsenal, AL 35898 USA. [Scalora, Michael] US Army RDECOM, AMRDEC, Charles M Bowden Res Lab, Redstone Arsenal, AL 35898 USA. RP Campione, S (reprint author), Sandia Natl Labs, Ctr Integrated Nanotechnol, POB 5800, Albuquerque, NM 87185 USA. EM sncampi@sandia.gov; f.capolino@uci.edu RI Campione, Salvatore/A-2349-2015 OI Campione, Salvatore/0000-0003-4655-5485 FU National Science Foundation [CM.MI-1101074]; National Research Council Research Associateship award at the U.S. Army Aviation and Missile Research Development and Engineering Center FX S.C., C. G., and F. C. acknowledge partial support from the National Science Foundation under Grant No. CM.MI-1101074. This research was performed while the authors D.d.C. and M. A. V. held a National Research Council Research Associateship award at the U.S. Army Aviation and Missile Research Development and Engineering Center. NR 32 TC 8 Z9 8 U1 8 U2 80 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD NOV 10 PY 2014 VL 105 IS 19 AR 191107 DI 10.1063/1.4901183 PG 5 WC Physics, Applied SC Physics GA AT8YZ UT WOS:000345216100007 ER PT J AU Ananworanich, J Datta, AA Fletcher, JL Townamchai, N Chomchey, N Kroon, E Sereti, I Valcour, V Kim, JH AF Ananworanich, Jintanat Datta, Anandita A. Fletcher, James Lk Townamchai, Natavudh Chomchey, Nitiya Kroon, Eugene Sereti, Irini Valcour, Victor Kim, Jerome H. TI Acute tubular nephropathy in a patient with acute HIV infection: review of the literature SO AIDS RESEARCH AND THERAPY LA English DT Article DE HIV; Acute renal failure; Acute tubular nephropathy; Acute retroviral syndrome; Acute HIV infection; Elderly ID IMMUNODEFICIENCY-VIRUS-INFECTION; RISK AB We report a 57-year old man with diabetes mellitus and hypertension who presented with acute HIV infection. Routine blood tests showed an elevated blood urea nitrogen and creatinine. Renal biopsy showed acute tubular nephropathy, which has not been reported to occur during acute HIV infection, in the absence of rhabdomyolysis or multiple organ system failure. Antiretroviral therapy was initiated. His renal failure gradually resolved without further intervention. At one year of follow-up his HIV RNA was undetectable, and his renal function was normal. The case illustrates a rare manifestation of acute HIV infection - acute renal failure - in an older man with diabetes and hypertension. In this setting acute kidney injury might mistakenly have been attributed to his chronic comorbidities, and this case supports early HIV-1 testing in the setting of a high index of suspicion. C1 [Ananworanich, Jintanat; Fletcher, James Lk; Chomchey, Nitiya; Kroon, Eugene] Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, Thailand. [Ananworanich, Jintanat; Townamchai, Natavudh] Chulalongkorn Univ, Dept Med, Fac Med, Bangkok 10330, Thailand. [Ananworanich, Jintanat; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Bethesda, MD 20817 USA. [Datta, Anandita A.] Joint Pathol Ctr, Div Nephropathol, Silver Spring, MD 20910 USA. [Sereti, Irini] Lab Immunoregulat, Clin & Mol Retrovirol Sect, Bethesda, MD 20892 USA. [Valcour, Victor] Univ Calif San Francisco, Memory & Aging Ctr, San Francisco, CA 94143 USA. RP Ananworanich, J (reprint author), Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, Thailand. EM jananworanich@hivresearch.org FU Thai Red Cross AIDS Research Center; US Military HIV Research Program; US National Institute of Allergy and Infectious Diseases FX We are grateful to Dr. Anchalee Avihingsanon, Dr. Opass Putcharoen, Ms. Peeriya Mangu, Ms. Duanghathai Suttichom and Ms. Sasiwimol Ubolyam for facilitating the clinical care of this patient. We thank Ms. Piraporn June Ohata for helping to prepare and submit the manuscript. This work was supported by the intramural research programs at the Thai Red Cross AIDS Research Center, US Military HIV Research Program and the US National Institute of Allergy and Infectious Diseases. NR 15 TC 0 Z9 0 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-6405 J9 AIDS RES THER JI Aids Res. Ther. PD NOV 7 PY 2014 VL 11 AR 34 DI 10.1186/1742-6405-11-34 PG 6 WC Infectious Diseases SC Infectious Diseases GA AX4YP UT WOS:000346935000001 PM 25745498 ER PT J AU Ettisserry, DP Goldsman, N Akturk, A Lelis, AJ AF Ettisserry, D. P. Goldsman, N. Akturk, A. Lelis, A. J. TI Structure, bonding, and passivation of single carbon-related oxide hole traps near 4H-SiC/SiO2 interfaces SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID SIO2; SILICA; SITES AB Single carbon interstitial in silicon dioxide, existing in carboxyl configuration, is shown to act as a border hole trap near 4H-SiC/SiO2 interface. Using density functional theory-based formation energy considerations, it is found to switch charge state between +2 and neutral as the 4H-SiC Fermi level sweeps its charge transition level located 1.4 eV above 4H-SiC valence band edge. Thus, carboxyl defect is predicted to be a potential candidate for threshold voltage instability in 4H-SiC MOSFETs. Post oxidation annealing of the interface with nitric oxide is shown to remove carboxyl defects. However, treating the defect in H-2 creates a hole trap level at 1.1 eV above 4H-SiC valence band edge similar to the original carboxyl defect. The stability of carboxyl and H2 treated carboxyl defects in their doubly positive state is explained on the basis of their structural and bonding transformations during hole capture. These include puckering and back-bonding of silicon with lattice oxygen as in the well-known oxygen vacancy (E' center) hole traps and an increase in the bond order between carboxyl carbon and oxygen. (C) 2014 AIP Publishing LLC. C1 [Ettisserry, D. P.; Goldsman, N.; Akturk, A.] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. [Goldsman, N.; Akturk, A.] CoolCAD Elect, College Pk, MD 20740 USA. [Lelis, A. J.] US Army Res Lab, Adelphi, MD 20783 USA. RP Ettisserry, DP (reprint author), Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. EM deva@umd.edu OI Ettisserry, Devanarayanan/0000-0002-4214-2141 NR 39 TC 4 Z9 4 U1 2 U2 44 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD NOV 7 PY 2014 VL 116 IS 17 AR 174502 DI 10.1063/1.4900981 PG 7 WC Physics, Applied SC Physics GA AT7ZH UT WOS:000345152900058 ER PT J AU Brown, TN O'Donovan, M Hasselquist, L Corner, B Schiffman, JM AF Brown, Tyler N. O'Donovan, Meghan Hasselquist, Leif Corner, Brian Schiffman, Jeffrey M. TI Soldier-relevant loads impact lower limb biomechanics during anticipated and unanticipated single-leg cutting movements SO JOURNAL OF BIOMECHANICS LA English DT Article DE Joint power; Kinematics; Kinetics; Locomotion; Backpack; Stance time ID LOWER-EXTREMITY BIOMECHANICS; CRUCIATE LIGAMENT INJURY; JOINT COORDINATE SYSTEM; GROUND REACTION FORCES; KNEE-JOINT; SPATIOTEMPORAL PARAMETERS; DROP-LANDINGS; BACKPACK LOAD; ACL INJURY; KINEMATICS AB This study quantified how body borne load impacts hip and knee biomechanics during anticipated and unanticipated single-leg cutting maneuvers. Fifteen male military personnel performed a series of single-leg cutting maneuvers with three different load configurations (light, similar to 6 kg, medium, similar to 20 kg, and heavy, similar to 40 kg). Subject-based means of the specific lower limb biomechanical variables were submitted to repeated measures ANOVA to test the main and interaction effects of body borne load and movement type. With body borne load, stance time (P<0.001) increased, while larger hip (P=0.027) and knee flexion (P=0.004), and hip adduction (P<0.001) moments, and decreased hip (P=0.002) and knee flexion (P<0.001), and hip adduction (P=0.003) postures were evident. Further, the hip (P<0.001) and ankle (P=0.024) increased energy absorption, while the knee (P=0.020) increased energy generation with body borne load. During the unanticipated maneuvers, the hip (P=0.009) and knee (P=0.032) increased energy generation, and peak hip flexion moment (P=0.002) increased relative to the anticipated movements. With the body borne load, participants adopted biomechanical patterns that decreased their locomotive ability including larger moments and reduced flexion postures of the lower limb. During the single-leg cut, participants used greater energy absorption from the large, proximal muscles of the hip and greater energy generation from the knee with the addition of load. Participant's performance when carrying a range of loads was not compromised by anticipation, as they did not exhibit the hip and knee kinetic and kinematic adaptations previously demonstrated when reacting to an unplanned stimulus. Published by Elsevier Ltd. C1 [Brown, Tyler N.] Oak Ridge Inst Sci & Educ, Belcamp, MD USA. [Brown, Tyler N.; O'Donovan, Meghan; Hasselquist, Leif; Corner, Brian; Schiffman, Jeffrey M.] US Army, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. [Schiffman, Jeffrey M.] Liberty Mutual Res Inst Safety, Hopkinton, MA USA. RP Brown, TN (reprint author), Natick Soldier RD & E Ctr, Dept Army, 15 Kansas St, Natick, MA 01760 USA. EM tyler.n.brown4.civ@mail.mil FU Competitive In-house Laboratory Independent Research (ILIR) Award program from the Department of the Army, Office of the Assistant Secretary of the Army - Acquisition Logistics and Technology FX This work was supported by a FY 2012-2014 Competitive In-house Laboratory Independent Research (ILIR) Award program from the Department of the Army, Office of the Assistant Secretary of the Army - Acquisition Logistics and Technology. The authors thank Ms. Marina Carboni and Mr. Albert Adams for their assistance with this study. NR 47 TC 5 Z9 5 U1 0 U2 15 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0021-9290 EI 1873-2380 J9 J BIOMECH JI J. Biomech. PD NOV 7 PY 2014 VL 47 IS 14 BP 3494 EP 3501 DI 10.1016/j.jbiomech.2014.09.002 PG 8 WC Biophysics; Engineering, Biomedical SC Biophysics; Engineering GA AT8KZ UT WOS:000345183500010 PM 25257813 ER PT J AU AbdulHameed, MDM Tawa, GJ Kumar, K Ippolito, DL Lewis, JA Stallings, JD Wallqvist, A AF AbdulHameed, Mohamed Diwan M. Tawa, Gregory J. Kumar, Kamal Ippolito, Danielle L. Lewis, John A. Stallings, Jonathan D. Wallqvist, Anders TI Systems Level Analysis and Identification of Pathways and Networks Associated with Liver Fibrosis SO PLOS ONE LA English DT Article ID STELLATE CELL-MIGRATION; HUMAN HEART-FAILURE; LARGE GENE LISTS; HEPATIC-FIBROSIS; PROBE LEVEL; DATA SETS; EXPRESSION; DATABASE; MECHANISMS; INJURY AB Toxic liver injury causes necrosis and fibrosis, which may lead to cirrhosis and liver failure. Despite recent progress in understanding the mechanism of liver fibrosis, our knowledge of the molecular-level details of this disease is still incomplete. The elucidation of networks and pathways associated with liver fibrosis can provide insight into the underlying molecular mechanisms of the disease, as well as identify potential diagnostic or prognostic biomarkers. Towards this end, we analyzed rat gene expression data from a range of chemical exposures that produced observable periportal liver fibrosis as documented in DrugMatrix, a publicly available toxicogenomics database. We identified genes relevant to liver fibrosis using standard differential expression and co-expression analyses, and then used these genes in pathway enrichment and protein-protein interaction (PPI) network analyses. We identified a PPI network module associated with liver fibrosis that includes known liver fibrosis-relevant genes, such as tissue inhibitor of metalloproteinase-1, galectin-3, connective tissue growth factor, and lipocalin-2. We also identified several new genes, such as perilipin-3, legumain, and myocilin, which were associated with liver fibrosis. We further analyzed the expression pattern of the genes in the PPI network module across a wide range of 640 chemical exposure conditions in DrugMatrix and identified early indications of liver fibrosis for carbon tetrachloride and lipopolysaccharide exposures. Although it is well known that carbon tetrachloride and lipopolysaccharide can cause liver fibrosis, our network analysis was able to link these compounds to potential fibrotic damage before histopathological changes associated with liver fibrosis appeared. These results demonstrated that our approach is capable of identifying early-stage indicators of liver fibrosis and underscore its potential to aid in predictive toxicity, biomarker identification, and to generally identify disease-relevant pathways. C1 [AbdulHameed, Mohamed Diwan M.; Tawa, Gregory J.; Kumar, Kamal; Wallqvist, Anders] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, High Performance Comp Software Applicat Inst, Dept Def Biotechnol, Ft Detrick, MD 21702 USA. [Ippolito, Danielle L.; Lewis, John A.; Stallings, Jonathan D.] US Army Ctr Environm Hlth Res, Ft Detrick, MD USA. RP Wallqvist, A (reprint author), US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, High Performance Comp Software Applicat Inst, Dept Def Biotechnol, Ft Detrick, MD 21702 USA. EM awallqvist@bhsai.org RI AbdulHameed, Mohamed Diwan M/O-3088-2015; OI AbdulHameed, Mohamed Diwan M/0000-0003-1483-4084; Stallings, Jonathan/0000-0002-6430-5888; Kumar, Kamal/0000-0002-9470-6682; wallqvist, anders/0000-0002-9775-7469 FU Military Operational Medicine Research Program; U.S. Army's Network Science Initiative, U.S. Army Medical Research and Materiel Command (USAMRMC); U.S. Department of Energy; USAMRMC FX The authors were supported by the Military Operational Medicine Research Program and the U.S. Army's Network Science Initiative, U.S. Army Medical Research and Materiel Command (USAMRMC, http://mrmc.amedd.army.mil), Ft. Detrick, MD. This research was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Center for Environmental Health Research (USACEHR, http://usacehr.amedd.army.mil) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USAMRMC. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 84 TC 12 Z9 13 U1 3 U2 21 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 7 PY 2014 VL 9 IS 11 AR e112193 DI 10.1371/journal.pone.0112193 PG 14 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AT3WF UT WOS:000344863100061 PM 25380136 ER PT J AU Atanasov, SE Oldham, CJ Slusarski, KA Taggart-Scarff, J Sherman, SA Senecal, KJ Filocamo, SF McAllister, QP Wetzel, ED Parsons, GN AF Atanasov, Sarah E. Oldham, Christopher J. Slusarski, Kyle A. Taggart-Scarff, Joshua Sherman, Shalli A. Senecal, Kris J. Filocamo, Shaun F. McAllister, Quinn P. Wetzel, Eric D. Parsons, Gregory N. TI Improved cut-resistance of Kevlar (R) using controlled interface reactions during atomic layer deposition of ultrathin (< 50 angstrom) inorganic coatings SO JOURNAL OF MATERIALS CHEMISTRY A LA English DT Article ID SHEAR THICKENING FLUID; MECHANICAL-PROPERTIES; BALLISTIC IMPACT; THIN-FILMS; FIBERS; FABRICS; PROTECTION; POLYMERS; FAILURE; ENERGY AB Conformal atomic layer deposition (ALD) of Al2O3 and TiO2 thin films on Kevlar (R), poly(p-phenylene terephthalamide) (PPTA) fibers at 50 and 100 degrees C affects the fiber cut resistance. Systematic studies of ALD coatings between 10 to 400 angstrom thick formed at 50 and 100 degrees C revealed excellent conformality, and trends in cutting performance depended on materials and process details. A 50 angstrom/50 angstrom TiO2/Al2O3 bilayer formed at 50 degrees C increased cut resistance of PPTA by 30% compared to untreated fiber materials. In situ infrared analysis shows that trimethylaluminum (TMA) Al2O3 precursor reacts sub-surface with PPTA and tends to degraded mechanical performance. The TiCl4 TiO2 precursor reacts to form a barrier that limits TMA/PPTA interactions, allowing a harder Al2O3 layer to form on top of TiO2. The thin ALD coatings do not substantially affect durability, flexibility, or weight of the PPTA, making ALD a potentially viable means to enhance the protective properties of Kevlar and other polymer fiber systems. C1 [Atanasov, Sarah E.; Oldham, Christopher J.; Parsons, Gregory N.] N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA. [Slusarski, Kyle A.; Taggart-Scarff, Joshua; McAllister, Quinn P.; Wetzel, Eric D.] Army Res Lab, Aberdeen Proving Ground, MD USA. [Sherman, Shalli A.; Senecal, Kris J.; Filocamo, Shaun F.] US Army Natick Res, Ctr Dev & Engn, Natick, MA USA. RP Parsons, GN (reprint author), N Carolina State Univ, Dept Chem & Biomol Engn, Campus Box 7905, Raleigh, NC 27695 USA. EM parsons@ncsu.edu RI Parsons, Gregory/O-9762-2014 OI Parsons, Gregory/0000-0002-0048-5859 FU State of North Carolina; National Science Foundation; US Army FX The authors acknowledge R. Garcia and F. Stevie at the Analytical Instrumentation Facility (AIF) for assistance with TEM and XPS analysis, respectively. AIF is located at North Carolina State University and is supported by the State of North Carolina and the National Science Foundation. We are also thankful to the US Army for funding this research. NR 33 TC 8 Z9 8 U1 3 U2 45 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2050-7488 EI 2050-7496 J9 J MATER CHEM A JI J. Mater. Chem. A PD NOV 7 PY 2014 VL 2 IS 41 BP 17371 EP 17379 DI 10.1039/c4ta03662j PG 9 WC Chemistry, Physical; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Energy & Fuels; Materials Science GA AQ4JW UT WOS:000342763300022 ER PT J AU Caballero, IS Yen, JY Hensley, LE Honko, AN Goff, AJ Connor, JH AF Caballero, Ignacio S. Yen, Judy Y. Hensley, Lisa E. Honko, Anna N. Goff, Arthur J. Connor, John H. TI Lassa and Marburg viruses elicit distinct host transcriptional responses early after infection SO BMC GENOMICS LA English DT Article DE Transcriptomics; Transcriptional response; Lassa virus; Marburg virus; Interferon-stimulated genes; Biomarker; Gene expression profile; Early stage diagnostics ID DIFFERENTIAL EXPRESSION ANALYSIS; HEMORRHAGIC-FEVER; CYNOMOLGUS MACAQUES; IMMUNE-RESPONSE; WEST-AFRICA; IN-VITRO; RNA-SEQ; EBOLA; APOPTOSIS; DISEASE AB Background: Lassa virus and Marburg virus are two causative agents of viral hemorrhagic fever. Their diagnosis is difficult because patients infected with either pathogen present similar nonspecific symptoms early after infection. Current diagnostic tests are based on detecting viral proteins or nucleic acids in the blood, but these cannot be found during the early stages of disease, before the virus starts replicating in the blood. Using the transcriptional response of the host during infection can lead to earlier diagnoses compared to those of traditional methods. Results: In this study, we use RNA sequencing to obtain a high-resolution view of the in vivo transcriptional dynamics of peripheral blood mononuclear cells (PBMCs) throughout both types of infection. We report a subset of host mRNAs, including heat-shock proteins like HSPA1B, immunoglobulins like IGJ, and cell adhesion molecules like SIGLEC1, whose differences in expression are strong enough to distinguish Lassa infection from Marburg infection in non-human primates. We have validated these infection-specific expression differences by using microarrays on a larger set of samples, and by quantifying the expression of individual genes using RT-PCR. Conclusions: These results suggest that host transcriptional signatures are correlated with specific viral infections, and that they can be used to identify highly pathogenic viruses during the early stages of disease, before standard detection methods become effective. C1 [Caballero, Ignacio S.] Boston Univ, Bioinformat Grad Program, Boston, MA 02215 USA. [Yen, Judy Y.; Connor, John H.] Boston Univ, Dept Microbiol, Sch Med, Boston, MA 02118 USA. [Hensley, Lisa E.; Honko, Anna N.; Goff, Arthur J.] US Army, Div Virol, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Hensley, Lisa E.; Honko, Anna N.] NIAID, Integrated Res Facil Ft Detrick, NIH, Ft Detrick, MD 21702 USA. RP Caballero, IS (reprint author), Boston Univ, Bioinformat Grad Program, 24 Cummington St, Boston, MA 02215 USA. EM nacho@bu.edu OI Connor, John/0000-0002-8867-7256; Honko, Anna/0000-0001-9165-148X FU National Institutes of Health [R01 AI1096159]; United States Army [W81XWH 100-02-0008, 11-02-0130]; Fulbright Commission Spain; Regional Government of Andalusia FX This work was supported by the National Institutes of Health grant R01 AI1096159, and the United States Army contracts W81XWH 100-02-0008 and 11-02-0130. ISC was supported by the Fulbright Commission Spain and the Regional Government of Andalusia. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 55 TC 6 Z9 6 U1 0 U2 7 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2164 J9 BMC GENOMICS JI BMC Genomics PD NOV 6 PY 2014 VL 15 AR 960 DI 10.1186/1471-2164-15-960 PG 12 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA AT9MH UT WOS:000345250900001 PM 25377889 ER PT J AU Yuan, H Newton, DL Seymour, LA Metz, A Cropek, D Holder, AA Ofoli, RY AF Yuan, Hao Newton, De'Andra L. Seymour, Luke A. Metz, Anja Cropek, Donald Holder, Alvin A. Ofoli, Robert Y. TI Characterization and functional assessment of a cobalt(III)-oxo cubane cluster water oxidation catalyst immobilized on ITO SO CATALYSIS COMMUNICATIONS LA English DT Article DE Electrochemical deposition; Catalyst recycle; Cyclic voltammetry; Artificial photosynthesis ID OXYGEN-EVOLVING COMPLEX; SYNTHETIC MODEL; PHOTOSYSTEM-II; CORE AB A cobalt(III) oxo cubane water oxidation catalyst, a structural mimic of the natural oxygen-evolving center, was immobilized on indium tin oxide (ITO) to promote recycling. The structure and composition of the complex were characterized by Fourier transform-infrared (FT-IR) spectroscopy, surface FT-IR, scanning electron microscopy, and energy dispersive X-ray spectroscopy. Cyclic voltammetry was used to assess catalyst functionality, stability, and recyclability. The results showed that this catalyst can be successfully immobilized on ITO, and that the complex functions in the same manner as the free catalyst in solution. This separation of synthesis and immobilization has great potential for optimizing heterogeneous catalysts. (C) 2014 Published by Elsevier B.V. C1 [Yuan, Hao; Ofoli, Robert Y.] Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA. [Newton, De'Andra L.; Seymour, Luke A.; Holder, Alvin A.] Old Dominion Univ, Dept Chem & Biochem, Norfolk, VA 23529 USA. [Metz, Anja; Cropek, Donald] US Army Corps Engineers, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. RP Ofoli, RY (reprint author), Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA. EM ofoli@egr.msu.edu RI Holder, Alvin/B-6329-2016 OI Holder, Alvin/0000-0001-9618-5297 FU U.S. Army Engineer Research and Development Center (Construction Engineering Research Laboratory) [W9132T-10-2-0025] FX This research was supported in part by the U.S. Army Engineer Research and Development Center (Construction Engineering Research Laboratory) (W9132T-10-2-0025), administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and ERDC-CERL. NR 11 TC 7 Z9 7 U1 3 U2 43 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1566-7367 EI 1873-3905 J9 CATAL COMMUN JI Catal. Commun. PD NOV 5 PY 2014 VL 56 BP 76 EP 80 DI 10.1016/j.catcom.2014.06.007 PG 5 WC Chemistry, Physical SC Chemistry GA AP7JB UT WOS:000342252500017 ER PT J AU Akhvlediani, T Bautista, CT Shakarishvili, R Tsertsvadze, T Imnadze, P Tatishvili, N Davitashvili, T Samkharadze, T Chlikadze, R Dvali, N Dzigua, L Karchava, M Gatserelia, L Macharashvili, N Kvirkvelia, N Habashy, EE Farrell, M Rowlinson, E Sejvar, J Hepburn, M Pimentel, G Dueger, E House, B Rivard, R AF Akhvlediani, Tamar Bautista, Christian T. Shakarishvili, Roman Tsertsvadze, Tengiz Imnadze, Paata Tatishvili, Nana Davitashvili, Tamar Samkharadze, Tamar Chlikadze, Rusudan Dvali, Natia Dzigua, Lela Karchava, Mariam Gatserelia, Lana Macharashvili, Nino Kvirkvelia, Nana Habashy, Engy Emil Farrell, Margaret Rowlinson, Emily Sejvar, James Hepburn, Matthew Pimentel, Guillermo Dueger, Erica House, Brent Rivard, Robert TI Etiologic Agents of Central Nervous System Infections among Febrile Hospitalized Patients in the Country of Georgia SO PLOS ONE LA English DT Article ID BACTERIAL-MENINGITIS; VIRAL-INFECTIONS; ENCEPHALITIS; EPIDEMIOLOGY; DIAGNOSIS AB Objectives: There is a large spectrum of viral, bacterial, fungal, and prion pathogens that cause central nervous system (CNS) infections. As such, identification of the etiological agent requires multiple laboratory tests and accurate diagnosis requires clinical and epidemiological information. This hospital-based study aimed to determine the main causes of acute meningitis and encephalitis and enhance laboratory capacity for CNS infection diagnosis. Methods: Children and adults patients clinically diagnosed with meningitis or encephalitis were enrolled at four reference health centers. Cerebrospinal fluid (CSF) was collected for bacterial culture, and in-house and multiplex RT-PCR testing was conducted for herpes simplex virus (HSV) types 1 and 2, mumps virus, enterovirus, varicella zoster virus (VZV), Streptococcus pneumoniae, HiB and Neisseria meningitidis. Results: Out of 140 enrolled patients, the mean age was 23.9 years, and 58% were children. Bacterial or viral etiologies were determined in 51% of patients. Five Streptococcus pneumoniae cultures were isolated from CSF. Based on in-house PCR analysis, 25 patients were positive for S. pneumoniae, 6 for N. meningitidis, and 1 for H. influenzae. Viral multiplex PCR identified infections with enterovirus (n = 26), VZV (n = 4), and HSV-1 (n = 2). No patient was positive for mumps or HSV-2. Conclusions: Study findings indicate that S. pneumoniae and enteroviruses are the main etiologies in this patient cohort. The utility of molecular diagnostics for pathogen identification combined with the knowledge provided by the investigation may improve health outcomes of CNS infection cases in Georgia. C1 [Akhvlediani, Tamar] Javakhishvili Tbilisi State Univ, Dept Neurol & Neurosurg, Tbilisi, Rep of Georgia. [Akhvlediani, Tamar] US Army, Med Res Unit Georgia, Tbilisi, Rep of Georgia. [Bautista, Christian T.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Shakarishvili, Roman] Sarajishvili Inst Clin Neurol & Neurosurg, Tbilisi, Rep of Georgia. [Tsertsvadze, Tengiz; Davitashvili, Tamar; Dvali, Natia; Dzigua, Lela; Karchava, Mariam; Gatserelia, Lana; Macharashvili, Nino] Sci Res Ctr Infect Pathol AIDS & Clin Immunol, Tbilisi, Rep of Georgia. [Imnadze, Paata; Chlikadze, Rusudan] Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia. [Tatishvili, Nana; Samkharadze, Tamar] Iashvili Childrens Hosp, Dept Neurol, Tbilisi, Rep of Georgia. [Habashy, Engy Emil; Farrell, Margaret; Rowlinson, Emily; Pimentel, Guillermo; Dueger, Erica; House, Brent] US Naval, Global Dis Detect & Response Program, Med Res Unit 3, Cairo, Egypt. [Sejvar, James] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA. [Dueger, Erica] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Hepburn, Matthew; Rivard, Robert] US Army, Med Res Inst Infect Dis, Frederick, MD USA. RP Akhvlediani, T (reprint author), Javakhishvili Tbilisi State Univ, Dept Neurol & Neurosurg, Tbilisi, Rep of Georgia. EM t_akhvlediani@yahoo.com FU U.S. Department of Defense Global Emerging Infections Surveillance (GEIS) Program; U.S. Centers for Disease Control and Prevention FX This work was funded by the U.S. Department of Defense Global Emerging Infections Surveillance (GEIS) Program and supported by the U.S. Centers for Disease Control and Prevention. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 21 TC 4 Z9 4 U1 0 U2 0 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 4 PY 2014 VL 9 IS 11 AR e111393 DI 10.1371/journal.pone.0111393 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AS6XG UT WOS:000344402000051 PM 25369023 ER PT J AU Alout, H Krajacich, BJ Meyers, JI Grubaugh, ND Brackney, DE Kobylinski, KC Diclaro, JW Bolay, FK Fakoli, LS Diabate, A Dabire, RK Bougma, RW Foy, BD AF Alout, Haoues Krajacich, Benjamin J. Meyers, Jacob I. Grubaugh, Nathan D. Brackney, Doug E. Kobylinski, Kevin C. Diclaro, Joseph W., II Bolay, Fatorma K. Fakoli, Lawrence S. Diabate, Abdoulaye Dabire, Roch K. Bougma, Roland W. Foy, Brian D. TI Evaluation of ivermectin mass drug administration for malaria transmission control across different West African environments SO MALARIA JOURNAL LA English DT Article DE Mass drug administration; Ivermectin; Transmission; West Africa; Malaria control; Plasmodium falciparum; Anopheles gambiae; Survival; Parity; Environment ID PLASMODIUM-FALCIPARUM; ANOPHELES-GAMBIAE; PARASITE TRANSMISSION; ALBENDAZOLE; MOSQUITOS; HUMANS; IMPACT AB Background: Mass drug administration (MDA) of ivermectin to humans for control and elimination of filarial parasites can kill biting malaria vectors and lead to Plasmodium transmission reduction. This study examines the degree and duration of mosquitocidal effects resulting from single MDAs conducted in three different West African countries, and the subsequent reductions in parity and Plasmodium sporozoite rates. Methods: Indoor-resting, blood-fed and outdoor host-seeking Anopheles spp. were captured on days surrounding MDAs from 2008-2013 in Senegalese, Liberian and Burkinabe villages. Mortality was assessed on a portion of the indoor collection, and parity status was determined on host-seeking mosquitoes. The effect of MDA was then analysed against the time relative to the MDA, the distributed drugs and environmental variables. Results: Anopheles gambiae survivorship was reduced by 33.9% for one week following MDA and parity rates were significantly reduced for more than two weeks after the MDAs. Sporozoite rates were significantly reduced by >77% for two weeks following the MDAs in treatment villages despite occurring in the middle of intense transmission seasons. These observed effects were consistent across three different West African transmission dynamics. Conclusions: These data provide a comprehensive and crucial evidence base for the significant reduction in malaria transmission following single ivermectin MDAs across diverse field sites. Despite the limited duration of transmission reduction, these results support the hypothesis that repeated MDAs with optimal timing could help sustainably control malaria as well as filarial transmission. C1 [Alout, Haoues; Krajacich, Benjamin J.; Meyers, Jacob I.; Grubaugh, Nathan D.; Brackney, Doug E.; Foy, Brian D.] Colorado State Univ, Dept Microbiol Immunol & Pathol, Arthropod Borne & Infect Dis Lab, Ft Collins, CO 80523 USA. [Meyers, Jacob I.] Colorado State Univ, Dept Biomed Sci, Ft Collins, CO 80523 USA. [Kobylinski, Kevin C.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Kobylinski, Kevin C.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Diclaro, Joseph W., II] US Naval Med Res Unit 3, Cairo, Egypt. [Bolay, Fatorma K.; Fakoli, Lawrence S.] Liberian Inst Biomed Res, Charlesville, Liberia. [Diabate, Abdoulaye; Dabire, Roch K.] Inst Rech Sci Sante, Direct Reg Ouest, Bobo Dioulasso, Burkina Faso. [Bougma, Roland W.] Minist Hlth, Ouagadougou, Burkina Faso. RP Alout, H (reprint author), Colorado State Univ, Dept Microbiol Immunol & Pathol, Arthropod Borne & Infect Dis Lab, Ft Collins, CO 80523 USA. EM haoues.alout@colostate.edu RI Alout, Haoues/N-9556-2016; Foy, Brian/E-6230-2017 OI Alout, Haoues/0000-0001-7917-2697; Foy, Brian/0000-0002-9117-203X FU National Institute of Allergy and Infectious Diseases [R21-AI079528, R01-AI094349-01A1]; US Armed Forces Health Surveillance Center: Global Emerging Infections Surveillance Network; Grand Challenges Explorations from the Bill and Melinda Gates Foundation [51995] FX We thank the local people in Senegal, Liberia and Burkina Faso for participating in this study, as well as the local authorities for their support. We are very grateful to the IRSS staff in Burkina Faso, to collaborators in Senegal and to the LIBR staff in Liberia for their technical assistance. We thank Infoscitex Corp for the use of their tent traps in our studies. We thank Jon Seaman, Meg Gray, Timothy Burton, and Wojtek Kuklinski for their assistance in mosquito processing. We are very thankful to Peter U Fischer for discussion and comments. We acknowledge and are grateful for support from National Institute of Allergy and Infectious Diseases grants R21-AI079528 and R01-AI094349-01A1, US Armed Forces Health Surveillance Center: Global Emerging Infections Surveillance Network, and Grand Challenges Explorations grant 51995 from the Bill and Melinda Gates Foundation. The funding sources had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 31 TC 12 Z9 12 U1 3 U2 10 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD NOV 3 PY 2014 VL 13 AR 417 DI 10.1186/1475-2875-13-417 PG 10 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AU6LF UT WOS:000345713900001 PM 25363349 ER PT J AU Valisetty, RR Dongare, AM Rajendran, AM Namburu, RR AF Valisetty, R. R. Dongare, A. M. Rajendran, A. M. Namburu, R. R. TI Atomistic Modeling of Spa 11 Response in a Single Crystal Aluminum SO CMC-COMPUTERS MATERIALS & CONTINUA LA English DT Article DE Molecular dynamics; void nucleation; spall stress; crystal orientation; strain rate ID VOID-GROWTH; DISLOCATION NUCLEATION; DUCTILE FRACTURE; DYNAMIC FAILURE; YIELD CRITERIA; STRAIN RATES; SPALLATION; STRENGTH; METALS; CU AB Materials used in soldier protective structures, such as armor, vehicles and civil infrastructures, are being improved for performance in extreme dynamic environments. Accordingly, atomistic molecular dynamics simulations were performed to study the spall response in a single crystal aluminum atom system. A planar 9.6 picoseconds (ps) shock pulse was generated through impacts with a shock piston at velocities ranging from 0.6 km/s to 1.5 km/s in three <1,0,0>, <1,1,0>, and <1,1,1> crystal orientations. In addition to characterizing the transient spall region width and duration, the spall response was characterized in terms of the traditional axial stress vs. axial strain response for gaining an understanding of the material failure in spall. Using an atom section averaging process, the snapshots, or the time history plots of the stress and strain axial distributions in the shock direction, were obtained from the MD simulations' outputs of the atom level stresses and displacements. These snapshots guided the analyses to an estimation of the spall widths and spall transients. The results were interpreted to highlight the effects of crystal orientation and impact velocity on the spall width, spall duration, spall stress, strain rate, critical strain values at the void nucleation, and the void volume fraction at the void coalescence. For all the combinations of the crystal orientations and the impact velocities, the void nucleation was observed when the stress reached a peak hydrostatic state and the stress triaxiality factor reached a minimum, i.e. by the simultaneous occurring of these three conditions for the stress state: 1. pressure reaching a negative minimum, 2. axial stress reaching the magnitude value of the peak pressure, and 3. the effective stress reaching a zero value. At these conditions, void nucleation was mainly caused by atom de-bonding. In fact, the void nucleation strains were shown to have been preceded by the strains of the stress triaxiality condition in this study, thus confirming the stress triaxiality condition for the void nucleation in spall. Based on the observation that the axial stress reached a maximum value of similar to 6 GPa during the void nucleation phase in spall and stayed approximately at that value for different crystal orientations and impact velocities, the value was proposed as a material spall strength. C1 [Valisetty, R. R.; Namburu, R. R.] Army Res Lab, Comp & Info Sci Directorate, Aberdeen Proving Ground, MD 21005 USA. [Dongare, A. M.] Univ Connecticut, Dept Mat Sci & Engn, Storrs, CT 06269 USA. [Rajendran, A. M.] Univ Mississippi, Dept Mech Engn, University, MS 38677 USA. RP Valisetty, RR (reprint author), Army Res Lab, Comp & Info Sci Directorate, Aberdeen Proving Ground, MD 21005 USA. EM ramakrishna.r.valisetty.civ@mail.mil; dongare@uconn.edu OI Dongare, Avinash/0000-0003-3189-3588 NR 47 TC 0 Z9 0 U1 0 U2 1 PU TECH SCIENCE PRESS PI NORCROSS PA 6825 JIMMY CARTER BLVD, STE 1850, NORCROSS, GA 30071 USA SN 1546-2218 EI 1546-2226 J9 CMC-COMPUT MATER CON JI CMC-Comput. Mat. Contin. PD NOV PY 2014 VL 44 IS 1 BP 23 EP 57 PG 35 WC Engineering, Multidisciplinary; Materials Science, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Materials Science; Mathematics GA CO9QL UT WOS:000359510300002 ER PT J AU Michael, N Kim, J Robb, M Thomas, R Haynes, B AF Michael, Nelson Kim, Jerome Robb, Merlin Thomas, Rasmi Haynes, Barton TI Advances in Prophylactic HIV Vaccine Development SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Meeting Abstract CT 16th Annual International Meeting of the Institute-of-Human-Virology (IHV) CY SEP 14-14, 2014 CL Univ Maryland Sch Med, Baltimore, MD SP Inst Human Virol HO Univ Maryland Sch Med C1 [Michael, Nelson; Kim, Jerome; Robb, Merlin; Thomas, Rasmi] Walter Reed Army Inst Res, Mil HIV Res Program, Silver Spring, MD USA. [Haynes, Barton] Duke Univ, Med Ctr, Duke Human Vaccine Inst, Durham, NC 27706 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD NOV PY 2014 VL 67 SU 3 MA E-102 BP 59 EP 59 PG 1 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CH6BF UT WOS:000354119800045 ER PT J AU Hughes, L Hamm, T Crawford, K Lenneman, T Kibuuka, H Maswai, J Clinkscales, J Robb, M Michael, N AF Hughes, Lindsay Hamm, Tiffany Crawford, Keith Lenneman, Tessa Kibuuka, Hannah Maswai, Jonah Clinkscales, Jessica Robb, Merlin Michael, Nelson TI Assessing quality of HIV treatment in the United States Military HIV Research Program/President's Emergency Plan for AIDS Relief (PEPFAR)-supported programs in Africa SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Meeting Abstract CT 16th Annual International Meeting of the Institute-of-Human-Virology (IHV) CY SEP 14-14, 2014 CL Univ Maryland Sch Med, Baltimore, MD SP Inst Human Virol HO Univ Maryland Sch Med C1 [Hughes, Lindsay; Hamm, Tiffany; Clinkscales, Jessica; Robb, Merlin; Michael, Nelson] US Mil HIV Res Program, Walter Reed Army Inst Res, Silver Spring, MD USA. [Hughes, Lindsay; Hamm, Tiffany; Crawford, Keith; Clinkscales, Jessica] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Crawford, Keith] US Mil HIV Res Program, Silver Spring, MD USA. [Crawford, Keith] Walter Reed Army Inst Res, Silver Spring, MD USA. [Lenneman, Tessa] Hosp Univ Munich, Dept Infect Dis & Trop Med, Munich, Germany. [Kibuuka, Hannah] Makerere Univ, Walter Reed Project, Kampala, Uganda. [Maswai, Jonah] Walter Reed Project Kenya, Kericho, Kenya. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD NOV PY 2014 VL 67 SU 3 MA P-A12 BP 81 EP 81 PG 1 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CH6BF UT WOS:000354119800084 ER PT J AU Kota, KP Soloveva, V Wanner, LM Gomba, G Kiris, E Panchal, RG Kane, CD Bavari, S AF Kota, Krishna P. Soloveva, Veronica Wanner, Laura M. Gomba, Glenn Kiris, Erkan Panchal, Rekha G. Kane, Christopher D. Bavari, Sina TI A High Content Imaging Assay for Identification of Botulinum Neurotoxin Inhibitors SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS LA English DT Article DE Neuroscience; Issue 93; neuroscience; neurobiology; Botulinum neurotoxin; Clostridium botulinum; high content imaging system; neurotoxicity ID SEROTYPE AB Synaptosomal-associated protein-25 (SNAP-25) is a component of the soluble NSF attachment protein receptor (SNARE) complex that is essential for synaptic neurotransmitter release. Botulinum neurotoxin serotype A (BoNT/A) is a zinc metalloprotease that blocks exocytosis of neurotransmitter by cleaving the SNAP-25 component of the SNARE complex. Currently there are no licensed medicines to treat BoNT/A poisoning after internalization of the toxin by motor neurons. The development of effective therapeutic measures to counter BoNT/A intoxication has been limited, due in part to the lack of robust high-throughput assays for screening small molecule libraries. Here we describe a high content imaging (HCI) assay with utility for identification of BoNT/A inhibitors. Initial optimization efforts focused on improving the reproducibility of inter-plate results across multiple, independent experiments. Automation of immunostaining, image acquisition, and image analysis were found to increase assay consistency and minimize variability while enabling the multiparameter evaluation of experimental compounds in a murine motor neuron system. C1 [Kota, Krishna P.] Perkin Elmer Inc, Waltham, MA 02451 USA. [Soloveva, Veronica; Kane, Christopher D.] Henry M Jackson Fdn, Bethesda, MD USA. [Wanner, Laura M.; Kiris, Erkan] Geneva Fdn, Tacoma, WA USA. [Gomba, Glenn] ORISE, Oak Ridge, TN USA. [Kiris, Erkan] Frederick Natl Lab Canc Res, Frederick, MD USA. [Kota, Krishna P.; Soloveva, Veronica; Wanner, Laura M.; Gomba, Glenn; Kiris, Erkan; Panchal, Rekha G.; Kane, Christopher D.; Bavari, Sina] US Army Med Res Inst Infect Dis, Div Mol & Translat Sci, Frederick, MD USA. [Soloveva, Veronica; Kane, Christopher D.] USAMRMC, TATRC, DoD Biotechnol High Performance Comp Software App, Frederick, MD USA. RP Kota, KP (reprint author), Perkin Elmer Inc, Waltham, MA 02451 USA. EM krishna.p.kota.ctr@mail.mil FU Joint Science and Technology Office - Chemical Biological Defense (JSTO-CBD) Defense Threat Reduction Agency (DTRA) [CB3675]; National Institutes of Health [1 R21 AI101387-01, 5 U01AI082051-05] FX Funding was provided by the Joint Science and Technology Office - Chemical Biological Defense (JSTO-CBD) Defense Threat Reduction Agency (DTRA) under sponsor project number CCAR# CB3675 and National Institutes of Health (1 R21 AI101387-01 and 5 U01AI082051-05). NR 14 TC 2 Z9 2 U1 1 U2 3 PU JOURNAL OF VISUALIZED EXPERIMENTS PI CAMBRIDGE PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA SN 1940-087X J9 JOVE-J VIS EXP JI J. Vis. Exp. PD NOV PY 2014 IS 93 AR e51915 DI 10.3791/51915 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CB0JH UT WOS:000349311400022 PM 25489815 ER PT J AU Montain, S Jonas, WB AF Montain, Scott Jonas, Wayne B. TI Nutritional Armor: Omega-3 for the Warfighter SO MILITARY MEDICINE LA English DT Editorial Material C1 [Montain, Scott] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. [Jonas, Wayne B.] Samueli Inst, Alexandria, VA 22314 USA. RP Montain, S (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, Bldg 42,Kansas St, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD NOV PY 2014 VL 179 IS 11 SU S BP 1 EP 1 DI 10.7205/MILMED-D-14-00452 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA CA7LS UT WOS:000349099400001 PM 25373086 ER PT J AU Washington, MA AF Washington, Michael A. TI Melanized Fungi and Military Medical Operations in the Nuclear Environment SO MILITARY MEDICINE LA English DT Editorial Material ID INFECTIONS C1 Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. RP Washington, MA (reprint author), Tripler Army Med Ctr, Dept Clin Invest, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 16 TC 0 Z9 0 U1 1 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD NOV PY 2014 VL 179 IS 11 BP 1181 EP 1183 DI 10.7205/MILMED-D-14-00152 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA CA7LK UT WOS:000349098600007 PM 25373038 ER PT J AU Melanson, VR Scheirer, JL Van de Wyngaerde, MT Bourzac, K Wu, SJ Kochel, T McAvin, JC AF Melanson, Vanessa R. Scheirer, Jessica L. Van de Wyngaerde, Marshall T. Bourzac, Kevin Wu, Shuenn-Jue Kochel, Tadeusz McAvin, James C. TI Leveraging Arthropod-Borne Disease Surveillance Assays for Clinical Diagnostic Use SO MILITARY MEDICINE LA English DT Article ID DENGUE VIRUS; IDENTIFICATION AB Researchers at the Walter Reed Army Institute of Research have taken a joint service approach to filling an identified diagnostic capability gap by leveraging a vector surveillance assay. Specifically, the Army took a field-stable real-time polymerase chain reaction assay, developed by the Air Force, for dengue virus surveillance in arthropod vectors and collaborated with Navy researchers for utility in human diagnostics. As current Department of Defense diagnostic PCR assays employ the Joint Biological Agent Identification and Diagnostic System, the dengue assay was tested for use on this platform. The low rates of false negative and false positive dengue samples in clinical matrices demonstrate excellent utility as a human diagnostic assay. Overall, converting an arboviral vector surveillance assay to human diagnostic assay and potentially vice versa is both cost effective and labor reducing. Codevelopment with harmonization of vector surveillance and diagnostics offers monetary and resource advantages to the Department of Defense and should be considered as a path forward in times when downsizing threatens assay development and pathogen discovery. C1 [Melanson, Vanessa R.; Scheirer, Jessica L.; Van de Wyngaerde, Marshall T.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Bourzac, Kevin] BioFire Diagnost Inc, Salt Lake City, UT 84108 USA. [Wu, Shuenn-Jue; Kochel, Tadeusz] Navy Med Res Ctr, Silver Spring, MD 20910 USA. [McAvin, James C.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Melanson, VR (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. FU Military Infectious Disease Research Program (MIDRP), Program Area L [L0245_12_WR] FX We thank Tobin Rowland for providing us with his knowledge and insectary support and Dr. Warren V. Kalina and Michael C. Yarnell for assistance provided in peer review. The study was funded by the Military Infectious Disease Research Program (MIDRP), Program Area L (L0245_12_WR), and conducted through a Walter Reed Army Institute of Research/BioFire Diagnostics Cooperative Research and Development Agreement. NR 15 TC 0 Z9 0 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD NOV PY 2014 VL 179 IS 11 BP 1207 EP 1211 DI 10.7205/MILMED-D-14-00019 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA CA7LK UT WOS:000349098600011 PM 25373042 ER PT J AU Ciuffreda, KJ Ludlam, DP Thiagarajan, P Yadav, NK Capo-Aponte, J AF Ciuffreda, Kenneth J. Ludlam, Diana P. Thiagarajan, Preethi Yadav, Naveen K. Capo-Aponte, Jose TI Proposed Objective Visual System Biomarkers for Mild Traumatic Brain Injury SO MILITARY MEDICINE LA English DT Article ID OCULOMOTOR REHABILITATION; EVOKED POTENTIALS; PROTOCOL; MTBI; DYSFUNCTIONS; POPULATION; CONCUSSION; TRACKING; TBI; VEP AB The challenge and search for objectively based biomarkers to assess for the presence of concussion/mild traumatic brain injury is a high priority for the military establishment. We present a documented overview of specific test areas and related targeted, high-yield, objectively based parameters that may be potential "vision biomarkers" for the detection of concussion/mild traumatic brain injury based on results from our laboratory and others, with emphasis on oculomotor aspects. These findings have military relevance with respect to the initial diagnosis in the battlefield and in the far-forward medical facilities, pre-/postdeployment issues, pre-/postvisual rehabilitation evaluation, fitness-for-duty assessment, and establishment of a return-to-duty timeline. C1 [Ciuffreda, Kenneth J.; Ludlam, Diana P.; Thiagarajan, Preethi; Yadav, Naveen K.] SUNY State Coll Optometry, Dept Biol & Vis Sci, New York, NY 10036 USA. [Capo-Aponte, Jose] Womack Army Med Ctr, Dept Optometry, Ft Bragg, NC 28310 USA. RP Ciuffreda, KJ (reprint author), SUNY State Coll Optometry, Dept Biol & Vis Sci, 33 West 42nd St, New York, NY 10036 USA. FU Department of Defense (DoD) [W81XWH-12-1-0240, W81XWH-10-1-0141]; Langeloth Foundation; College of Optometrists in Vision Development (COVD); William C. Ezell Fellowship FX We thank LTC James Truong for his helpful comments during manuscript preparation. Our studies were supported from the following sources: Department of Defense (DoD grants (W81XWH-12-1-0240 and W81XWH-10-1-0141), Langeloth Foundation, College of Optometrists in Vision Development (COVD), and the William C. Ezell Fellowship. NR 49 TC 5 Z9 5 U1 0 U2 9 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD NOV PY 2014 VL 179 IS 11 BP 1212 EP 1217 DI 10.7205/MILMED-D-14-00059 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA CA7LK UT WOS:000349098600012 PM 25373043 ER PT J AU Nadler, R Gendler, S Chen, J Lending, G Abramovitch, A Glassberg, E AF Nadler, Roy Gendler, Sami Chen, Jacob Lending, Gadi Abramovitch, Amir Glassberg, Elon TI The Israeli Defense Force Experience With Intraosseous Access SO MILITARY MEDICINE LA English DT Article ID INFUSION; SERVICE; DEVICES; EMS AB Introduction: Obtaining vascular access is of paramount importance in trauma care. When peripheral venous access is indicated but cannot be obtained, the intraosseous route represents an alternative. The Bone Injection Gun (BIG) is the device used for intraosseous access by the Israeli Defense Force (IDF). The purpose of this study is to assess the success rate of intraosseous access using this device. Method: The IDF Trauma Registry from 1999 to 2012 was searched for patients for whom at least 1 attempt at intraosseous access was made. Results: 37 attempts at intraosseous access were identified in 30 patients. Overall success rate was 50%. No differences in success rates were identified between different care givers. Overall mortality was 87%. Conclusion: The use of BIG in the IDF was associated with a low success rate at obtaining intraosseous access. Although inability to achieve peripheral venous access can be considered an indicator for poor prognosis, the high mortality rate for patients treated with BIG can also stand for the provider's low confidence in using this tool, making its use a last resort. This study serves as an example to ongoing learning process that includes data collection, analysis, and improvement, constantly taking place in the IDF. C1 [Nadler, Roy; Gendler, Sami; Chen, Jacob; Lending, Gadi; Abramovitch, Amir; Glassberg, Elon] Israel Def Forces, Surg Gen HQ, Trauma & Combat Med Branch, IL-5262000 Ramat Gan, Israel. [Chen, Jacob] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Nadler, R (reprint author), Israel Def Forces, Surg Gen HQ, Trauma & Combat Med Branch, Yaakov Dori Rd, IL-5262000 Ramat Gan, Israel. NR 15 TC 2 Z9 2 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD NOV PY 2014 VL 179 IS 11 BP 1254 EP 1257 DI 10.7205/MILMED-D-1400013 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA CA7LK UT WOS:000349098600019 PM 25373050 ER PT J AU Tubb, CC Oh, JS Do, NV Tai, NR Meissel, MP Place, ML AF Tubb, Creighton C. Oh, John S. Do, Nhan V. Tai, Nigel R. Meissel, Michael P. Place, Michael L. TI Trauma Care at a Multinational United Kingdom-Led Role 3 Combat Hospital: Resuscitation Outcomes From a Multidisciplinary Approach SO MILITARY MEDICINE LA English DT Article ID MAJOR LIMB TRAUMA; LEVEL-I; MASSIVE TRANSFUSION; CASUALTIES; MORTALITY; CENTERS; THEATER; INJURY; VOLUME; IRAQ AB Recent conflicts have led significant advancements in casualty care. Facilities serving combat wounded operate in challenging environments. Our purpose is to describe the multidisciplinary resuscitation algorithm utilized at a United Kingdom-led, Role 3 multinational treatment facility in Afghanistan focusing on injury severity and in-hospital mortality. Methods: Data were extracted from our prospectively collected trauma registry on military members wounded in action. Results: From November 1, 2009 to September 30, 2011, there were 3483 military trauma admissions. Common mechanisms of injury were improvised explosive devices (48%), followed by gunshot wounds (29%). Most patients (83.1%) had an Injury Severity Score (ISS) <15. For patients with complete ISS data, 8.4% had massive transfusion and 6.1% had an initial base deficit >5. Patients admitted with signs of life had a died of wounds rate of 1.8% with an average 1.2 day hospital stay. The mortality rate for patients undergoing massive transfusion was 4.8%, and for patients with a base deficit >5, mortality was 12.3%. Severely injured patients (ISS > 24) had a mortality rate of 16.5%. Conclusion: A systematic, multidisciplinary approach to trauma is associated with low in-hospital mortality. The outcomes in this study serve as a measure for future care in Role 3 facilities. C1 [Tubb, Creighton C.] San Antonio Mil Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. [Oh, John S.] Walter Reed Natl Mil Med Ctr, Dept Surg, Bethesda, MD 20889 USA. [Do, Nhan V.] Clin Capabil Management, Falls Church, VA 22042 USA. [Tai, Nigel R.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham B15 2SQ, W Midlands, England. [Meissel, Michael P.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Place, Michael L.] Natl Def Univ, Eisenhower Sch, Arlington, VA 22204 USA. RP Tubb, CC (reprint author), San Antonio Mil Med Ctr, Dept Orthopaed & Rehabil, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 24 TC 1 Z9 1 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD NOV PY 2014 VL 179 IS 11 BP 1258 EP 1262 DI 10.7205/MILMED-D-14-00042 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA CA7LK UT WOS:000349098600020 PM 25373051 ER PT J AU Matthews, T Abraham, J Zacher, LL Morris, MJ AF Matthews, Tokunbo Abraham, Joseph Zacher, Lisa L. Morris, Michael J. TI The Impact of Deployment on COPD in Active Duty Military Personnel SO MILITARY MEDICINE LA English DT Article ID GULF-WAR VETERANS; KUWAIT OIL FIRES; RESPIRATORY SYMPTOMS; AFGHANISTAN; EXPOSURE; ILLNESS; US AB Purpose: To identify trends in chronic obstructive pulmonary disease (COPD) diagnoses among active duty U.S. military personnel based on deployment history and whether International Classification of Disease, 9th edition (ICD-9) coding meet criteria for the diagnosis of COPD. Methods: A retrospective chart review using the electronic medical system was conducted for military personnel diagnosed with COPD based on ICD-9 codes for emphysema or chronic obstructive lung disease with at least three qualifying outpatient COPD-coded encounters. Clinical symptoms, smoking history, pulmonary function testing, and radiographs obtained during the diagnostic workup were reviewed. The established diagnosis of COPD was analyzed in relation to deployment. Results: A total of 371 patients were identified during the study period (2005-2009). Of these patients, 194 (52.3%) deployed, whereas 177 (47.7%) did not deploy to Southwest Asia since 2003. Thirty-four percent had no documented smoking history despite the diagnosis of COPD. Airway obstruction was identified by spirometry in only 67% of individuals diagnosed with COPD. No statistically significant differences in pulmonary function testing values were identified between those deployed and nondeployed individuals. Conclusion: Despite evidence of increased respiratory symptoms in deployed military personnel, the impact of deployment on increased diagnosis of COPD or severity of disease appears minimal. C1 [Matthews, Tokunbo] Joint Base Elmendorf Richardson Hosp, Pulm Dis Serv, Jber, AK 99506 USA. [Matthews, Tokunbo] US Army Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. [Zacher, Lisa L.] Orlando Vet Adm Hosp, Dept Med, Orlando, FL 32803 USA. [Morris, Michael J.] San Antonio Mil Med Ctr, Pulm Crit Care Serv, Dept Med, Ft Sam Houston, TX 78234 USA. RP Matthews, T (reprint author), Joint Base Elmendorf Richardson Hosp, Pulm Dis Serv, 5955 Zeamer Ave, Jber, AK 99506 USA. NR 12 TC 1 Z9 1 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD NOV PY 2014 VL 179 IS 11 BP 1273 EP 1278 DI 10.7205/MILMED-D-14-00066 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA CA7LK UT WOS:000349098600023 PM 25373054 ER PT J AU Gehrich, AP Patzwald, JR Kern, ME Squires, CC Lustik, MB AF Gehrich, Alan P. Patzwald, Jason R. Kern, Molly E. Squires, Chris C. Lustik, Michael B. TI The Incidence of Early and Recurrent Urinary Tract Infections After Midurethral Sling Operations SO MILITARY MEDICINE LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; ANTIBIOTIC-PROPHYLAXIS; INCONTINENCE SURGERY; STRESS-INCONTINENCE; WOMEN; COMPLICATIONS; RISK AB Objective: To define the incidence of early and recurrent urinary tract infections (RUTIs) in the 12-month postoperative period following midurethral sling (MUS) operations and evaluate for risk factors. Methods: This retrospective chart review compiled all urine analyses and urine culture results within 12 months of MUS surgery on all patients in the years 2006-2012 for which data were available. All coincident risk factors were tabulated. Statistical analysis was performed using SAS v 9.2 (SAS Institute, Cary, North Carolina). Results: 141 MUS procedures were performed in the 6-year time frame utilizing standard antibiotic prophylaxis regimens. 133 had adequate data for analysis. 10 patients (7.5% confidence intervals [CI] [3.7-12.4]) developed an acute UTI in the first 8 weeks postoperatively. 3 of 121 patients (2.3% CI [0.5-5.9]) developed RUTIs in the first year following surgery. Bivariate and multiple logistic regression analyses of the data did not reveal any risk factors for either isolated postoperative UTIs or RUTIs. Conclusions: This study documents a low incidence of both acute and RUTIs in the female population undergoing MUS operations. These results support the current recommendations for perioperative prophylactic antibiotics for anti-incontinence procedures. C1 [Gehrich, Alan P.; Patzwald, Jason R.; Kern, Molly E.; Squires, Chris C.; Lustik, Michael B.] Tripler Army Med Ctr, Dept Obstet & Gynecol, Honolulu, HI 96859 USA. [Lustik, Michael B.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. RP Gehrich, AP (reprint author), Tripler Army Med Ctr, Dept Obstet & Gynecol, Honolulu, HI 96859 USA. NR 19 TC 2 Z9 2 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD NOV PY 2014 VL 179 IS 11 BP 1301 EP 1306 DI 10.7205/MILMED-D-14-00122 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA CA7LK UT WOS:000349098600027 PM 25373058 ER PT J AU Bedno, S Hauret, K Loringer, K Kao, TC Mallon, T Jones, B AF Bedno, Sheryl Hauret, Keith Loringer, Kelly Kao, Tzu-Cheg Mallon, Timothy Jones, Bruce TI Effects of Personal and Occupational Stress on Injuries in a Young, Physically Active Population: A Survey of Military Personnel SO MILITARY MEDICINE LA English DT Article ID EXERCISE-RELATED INJURIES; FORCE SAFETY CENTER; FEMALE ARMY TRAINEES; LIMITED-DUTY DAYS; RISK-FACTORS; MUSCULOSKELETAL INJURIES; SPORTS INJURIES; PREVENTION; WORK; RECOMMENDATIONS AB The aim of this study was to document risk factors for any injury and sports- and exercise-related injuries, including personal and occupational stress among active duty service members (SMs) in the Air Force, Army, Marine Corps, and Navy. A total of 10,692 SMs completed the April 2008 Status of Forces Survey of Active Duty Members. The survey asked about demographics, personal stress and occupational stress, injuries from any cause, and participation in sports-and exercise-related activities in the past year. The survey used a complex sampling procedure to create a representative sample of SMs. Logistic regression was used to examine the associations of injury outcomes with potential risk factors. 49% of SMs sought medical care for an injury in the past year and 25% sustained a sports-and exercise-related activities injury. Odds of injury were higher for the Army and Marine Corps than for the Air Force or Navy. This survey showed that higher personal and occupational stress was associated with higher risks of injury. SMs who experienced higher levels of personal or occupational stress reported higher risks of injuries. The effects of stress reduction programs on injury risks should be evaluated in military and other young physically active populations. C1 [Bedno, Sheryl] William Beaumont Army Med Ctr, Dept Clin Invest, El Paso, TX 79920 USA. [Hauret, Keith; Jones, Bruce] US Army Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. [Loringer, Kelly] 28th Med Grp, Ellsworth AFB, SD 57706 USA. [Kao, Tzu-Cheg; Mallon, Timothy] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. RP Bedno, S (reprint author), William Beaumont Army Med Ctr, Dept Clin Invest, 5005 Piedras, El Paso, TX 79920 USA. FU Uniformed Services University of the Health Sciences [CO874F] FX This study received an intramural grant (CO874F) from the Uniformed Services University of the Health Sciences. NR 47 TC 1 Z9 1 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD NOV PY 2014 VL 179 IS 11 BP 1311 EP 1318 DI 10.7205/MILMED-D-14-00080 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA CA7LK UT WOS:000349098600029 PM 25373060 ER PT J AU Spooner, SP Tyner, SD Sowers, C Tsao, J Stuessi, K AF Spooner, Shawn P. Tyner, Stuart D. Sowers, Christopher Tsao, Jack Stuessi, Keith TI Utility of a Sports Medicine Model in Military Combat Concussion and Musculoskeletal Restoration Care SO MILITARY MEDICINE LA English DT Article ID OPERATION-IRAQI-FREEDOM; INJURY; RETURN; DUTY; WAR AB Combat-related concussions are significant sources of injury and morbidity among deployed military service members. Musculoskeletal injury also is one of the most prevalent battle and nonbattle-related deployed injury types. Both injuries threaten the service member's physical condition as well as unit and mission readiness due to reduced duty status or evacuation from military theater of operations. In August 2010, the Concussion Restoration Care Center (CRCC) was established at Camp Leatherneck, Afghanistan, to address the need for consistent and specialized evaluation and care of concussion and musculoskeletal injury. This performance improvement effort examined evaluation and treatment of concussion and musculoskeletal injury at the CRCC. Among 4,947 military personnel evaluated at the CRCC between August 2010 and May 2013, 97.9% were returned to duty and retained in theater. Members averaged 10 to 12 days of limited duty status to achieve complete recovery. Concussion injury was secondary to blast injury in 90% of cases. Sport/recreation, occupational, and other accidental injuries each represented 30% of the musculoskeletal injuries with only 10% reported as result of combat. The utilization patterns and outcome measures demonstrate the success and utility of a multidisciplinary clinical model of care for these two types of injuries in the far-forward deployed setting. C1 [Spooner, Shawn P.] Captain James A Lovell Fed Healthcare Ctr, N Chicago, IL 60064 USA. [Spooner, Shawn P.] Unity Point Clin, Des Moines, IA 50322 USA. [Spooner, Shawn P.] Unity Point Clin Sports Med Urbandale, Urbandale, IA 50322 USA. [Tyner, Stuart D.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Stuessi, Keith] Naval Hosp Camp Pendleton, Camp Pendleton, CA 92055 USA. [Tsao, Jack] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Spooner, SP (reprint author), Captain James A Lovell Fed Healthcare Ctr, 3001 Green Bay Rd, N Chicago, IL 60064 USA. NR 12 TC 0 Z9 0 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD NOV PY 2014 VL 179 IS 11 BP 1319 EP 1324 DI 10.7205/MILMED-D-14-00191 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA CA7LK UT WOS:000349098600030 PM 25373061 ER PT J AU Jones, RS Simmons, A Boykin, GL Stamper, D Thompson, JC AF Jones, Robert S. Simmons, Angela Boykin, Gary L., Sr. Stamper, David Thompson, Jennifer C. TI Measuring Intravenous Cannulation Skills of Practical Nursing Students Using Rubber Mannequin Intravenous Training Arms SO MILITARY MEDICINE LA English DT Article ID SIMULATION AB This study examined the effectiveness of two training methods for peripheral intravenous (IV) cannulation; one using rubber mannequin IV training arms, and the other consisting of students performing the procedure on each other. Two hundred-sixty Phase II Army Practical Nursing students were randomized into two groups and trained to perform an IV cannulation procedure. All students watched a 12-minute training video covering standard IV placement procedures. Afterward, both groups practiced the procedure for an hour according to their assigned group. Students were then tested on IV placement in a live human arm using a 14-item testing instrument in three trials that were scored pass/fail. There was no difference in the groups' performance of the IV procedure on the first attempt: 51.7% (n = 92) of the human arm group passed the test, and 48.3% (n = 86) of the rubber mannequin group passed the test (p = 0.074). These data suggest that using rubber mannequin IV arms for IV skills training may be just as effective as training students using traditional methods. In addition, using simulation provides an extra benefit of reducing risks associated with learning the procedure on a fellow student. C1 [Jones, Robert S.] Army Med Dept Ctr & Sch, Dept Nursing Sci, Ft Sam Houston, TX 78234 USA. [Simmons, Angela] Brooke Army Med Ctr, Ctr Nursing Sci & Clin Inquiry, Ft Sam Houston, TX 78234 USA. [Boykin, Gary L., Sr.] US Army Res Lab, AMEDD, Ft Sam Houston, TX 78234 USA. [Stamper, David] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Thompson, Jennifer C.] Orlando VA Med Ctr, Orlando, FL 32803 USA. RP Jones, RS (reprint author), Army Med Dept Ctr & Sch, Dept Nursing Sci, 3490 Forage Rd, Ft Sam Houston, TX 78234 USA. NR 17 TC 2 Z9 2 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD NOV PY 2014 VL 179 IS 11 BP 1361 EP 1367 DI 10.7205/MILMED-D-13-00576 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA CA7LK UT WOS:000349098600036 PM 25373067 ER PT J AU Cranor, LF Buchler, N AF Cranor, Lorrie Faith Buchler, Norbou TI Better Together: Usability and Security Go Hand in Hand SO IEEE SECURITY & PRIVACY LA English DT Article C1 [Cranor, Lorrie Faith] Carnegie Mellon Univ, Pittsburgh, PA 15213 USA. [Buchler, Norbou] US Army Res Lab, Human Res & Engn Directorate, Washington, DC USA. RP Cranor, LF (reprint author), Carnegie Mellon Univ, Pittsburgh, PA 15213 USA. EM lorrie@acm.org; norbou.buchler.civ@mail.mil OI Cranor, Lorrie/0000-0003-2125-0124 NR 17 TC 0 Z9 0 U1 2 U2 5 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1540-7993 EI 1558-4046 J9 IEEE SECUR PRIV JI IEEE Secur. Priv. PD NOV-DEC PY 2014 VL 12 IS 6 BP 89 EP 93 PG 5 WC Computer Science, Information Systems; Computer Science, Software Engineering SC Computer Science GA AZ2JC UT WOS:000348059000015 ER PT J AU Apland, JP Aroniadou-Anderjaska, V Figueiredo, TH Rossetti, F Miller, SL Braga, MFM AF Apland, James P. Aroniadou-Anderjaska, Vassiliki Figueiredo, Taiza H. Rossetti, Franco Miller, Steven L. Braga, Maria F. M. TI The Limitations of Diazepam as a Treatment for Nerve Agent-Induced Seizures and Neuropathology in Rats: Comparison with UBP302 SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS LA English DT Article ID REFRACTORY STATUS EPILEPTICUS; RECEPTOR ANTAGONIST LY293558; SOMAN-INDUCED SEIZURES; ANXIETY-LIKE BEHAVIOR; BASOLATERAL AMYGDALA; GABA(A) RECEPTORS; KAINATE RECEPTORS; PILOCARPINE MODEL; FOLLOW-UP; HIPPOCAMPUS AB Exposure to nerve agents induces prolonged status epilepticus (SE), causing brain damage or death. Diazepam (DZP) is the current US Food and Drug Administration-approved drug for the cessation of nerve agent-induced SE. Here, we compared the efficacy of DZP with that of UBP302 [(S)-3-(2-carboxybenzyl) willardiine; an antagonist of the kainate receptors that contain the GluK1 subunit] against seizures, neuropathology, and behavioral deficits induced by soman in rats. DZP, administered 1 hour or 2 hours postexposure, terminated the SE, but seizures returned; thus, the total duration of SE within 24 hours after soman exposure was similar to (DZP at 1 hour) or longer than (DZP at 2 hours) that in the soman-exposed rats that did not receive the anticonvulsant. Compared with DZP, UBP302 stopped SE with a slower time course, but dramatically reduced the total duration of SE within 24 hours. Neuropathology and behavior were assessed in the groups that received anticonvulsant treatment 1 hour after exposure. UBP302, but not DZP, reduced neuronal degeneration in a number of brain regions, as well as neuronal loss in the basolateral amygdala and the CA1 hippocampal area, and prevented interneuronal loss in the basolateral amygdala. Anxiety-like behavior was assessed in the open field and by the acoustic startle response 30 days after soman exposure. The results showed that anxiety-like behavior was increased in the DZP-treated group and in the group that did not receive anticonvulsant treatment, but not in the UBP302-treated group. The results argue against the use of DZP for the treatment of nerve agent-induced seizures and brain damage and suggest that targeting GluK1-containing receptors is a more effective approach. C1 [Apland, James P.] US Army, Med Res Inst Chem Def, Neurotoxicol Branch, Aberdeen Proving Ground, MD 21010 USA. [Aroniadou-Anderjaska, Vassiliki; Figueiredo, Taiza H.; Miller, Steven L.; Braga, Maria F. M.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA. [Aroniadou-Anderjaska, Vassiliki; Braga, Maria F. M.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Psychiat, Bethesda, MD 20814 USA. RP Braga, MFM (reprint author), Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Anat Physiol & Genet, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM maria.braga@usuhs.edu OI Miller, Steven/0000-0002-2061-8188 FU National Institutes of Health Office of the Director; National Institutes of Health National Institute of Neurologic Disorders and Stroke CounterACT Program [5U01-NS058162-07] FX This work was supported by the National Institutes of Health Office of the Director and the National Institutes of Health National Institute of Neurologic Disorders and Stroke CounterACT Program [Grant 5U01-NS058162-07]. The views expressed in this article are those of the authors and do not reflect the official policy of the Department of the Army, the Department of Defense, or the US Government. NR 64 TC 10 Z9 10 U1 0 U2 8 PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA SN 0022-3565 EI 1521-0103 J9 J PHARMACOL EXP THER JI J. Pharmacol. Exp. Ther. PD NOV PY 2014 VL 351 IS 2 BP 359 EP 372 DI 10.1124/jpet.114.217299 PG 14 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA CA2LK UT WOS:000348739800005 PM 25157087 ER PT J AU West, JC Wilk, JE Duffy, FF Kuramoto, SJ Rae, DS Moscicki, EK Hoge, CW AF West, Joyce C. Wilk, Joshua E. Duffy, Farifteh F. Kuramoto, S. Janet Rae, Donald S. Moscicki, Eve K. Hoge, Charles W. TI Mental Health Treatment Access and Quality in the Army: Survey of Mental Health Clinicians SO JOURNAL OF PSYCHIATRIC PRACTICE LA English DT Article DE mental health; substance abuse; access; quality; military ID RATES; IRAQ AB Objective. The goal of this study was to identify factors affecting timely, quality mental health and substance abuse treatment for service members and characterize patients at the greatest risk of having problems accessing treatment. Methods. An electronic survey was emailed to 2,310 Army mental healthcare providers. After providers with undeliverable emails and who self-reported not being behavioral health providers were excluded, 543 (26%) of the remaining 2,104 providers responded. This represented approximately a quarter of all Army behavioral health providers at the time of the survey. Of these 543 providers, 399 (73%) reported treating at least one service member during their last typical work week and provided clinically detailed data on one systematically selected service member. Results. The majority of the clinicians reported being able to spend sufficient time with patients (91.8%) and schedule encounters to meet patients' needs (82.4%). The clinicians also identified services where treatment access was more limited and patient subgroups with an unmet need for additional clinical care or services. Specifically, a significant proportion of clinicians reported that they were "never, rarely, or sometimes" able to provide or arrange for mental health treatment for the sampled service member's children (52.0%), provide or arrange for marriage and family therapy (40.1%), coordinate care effectively with primary care (36.7%), provide or arrange for care/case management (28.3%), or provide or arrange for substance abuse treatment (24.9%). Patients with more severe symptoms and diagnostic and clinical complexity had higher rates of problems with treatment access. Conclusions. Our findings highlight opportunities to improve access to timely, quality treatment for service members and their families. C1 [West, Joyce C.; Duffy, Farifteh F.; Kuramoto, S. Janet; Rae, Donald S.; Moscicki, Eve K.] Amer Psychiat Inst Res & Educ, Arlington, VA USA. [Wilk, Joshua E.; Hoge, Charles W.] Walter Reed Army Inst Res, Dept Mil Psychiat, Ctr Mil Psychiat & Neurosci Res, Silver Spring, MD USA. RP West, JC (reprint author), Amer Psychiat Fdn, Amer Psychiat Inst Res & Educ, 1000 Wilson Blvd,Suite 1825, Arlington, VA 22209 USA. EM Jwest@psych.org FU Walter Reed Army Institute of Research; Army Office of the Surgeon General FX Acknowledgements: This study was funded by the Walter Reed Army Institute of Research. We thank the U.S. Army behavioral health providers and the Army Office of the Surgeon General for their support and participation in this study and for their service to our nation. We thank the Mountain West Research Center for their work in developing the on-line survey. NR 20 TC 2 Z9 2 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1527-4160 EI 1538-1145 J9 J PSYCHIATR PRACT JI J. Psychiatr. Pract. PD NOV PY 2014 VL 20 IS 6 BP 448 EP 459 DI 10.1097/01.pra.0000456593.58739.61 PG 12 WC Psychiatry SC Psychiatry GA CA0CR UT WOS:000348583000005 PM 25406049 ER PT J AU Ivashchenko, VI Scrynskyy, PL Lytvyn, OS Butenko, OO Sinelnichenko, OK Gorb, L Hill, F Leszczynski, J Kozak, AO AF Ivashchenko, V. I. Scrynskyy, P. L. Lytvyn, O. S. Butenko, O. O. Sinelnichenko, O. K. Gorb, L. Hill, F. Leszczynski, J. Kozak, A. O. TI Comparative investigation of NbN and Nb-Si-N films: Experiment and theory SO JOURNAL OF SUPERHARD MATERIALS LA English DT Article DE NbN and Nb-Si-N films; magnetron sputtering; film structure; bonding picture; nanoindentation; first-principles calculations; stress-strain curves ID NITRIDE THIN-FILMS; ARC-DEPOSITED NBN; MECHANICAL-PROPERTIES; MULTILAYER COATINGS; MICROSTRUCTURE; MULTICOMPONENT; HARDNESS AB NbN and Nb-Si-N films have been deposited by magnetron sputtering of the Nb and Si targets on silicon wafers at various powers supplied to the Nb target. The films have been investigated by an atomic force microscope, X-ray diffraction, X-ray photoelectron spectroscopy, nanoindentaion and microindentation. The NbN films were nanostructured, and the Nb-Si-N films represented an aggregation of delta-NbN (x) nanocrystallites embedded into the amorphous Si3N4 matrix (nc-delta-NbN (x) /a-Si3N4). The annealing of the films in vacuum showed that their intensive oxidation occurred at annealing temperature higher than 600A degrees C. To explain the experimental results on the Nb-Si-N films, first-principles molecular dynamics simulations of the NbN(001)/Si3N4 heterostructures have been carried out. C1 [Ivashchenko, V. I.; Scrynskyy, P. L.; Butenko, O. O.; Sinelnichenko, O. K.; Kozak, A. O.] Natl Acad Sci Ukraine, Frantsevich Inst Mat Sci Problems, UA-03680 Kiev, Ukraine. [Lytvyn, O. S.] Natl Acad Sci, Lashkarev Inst Phys Semicond, UA-03028 Kiev, Ukraine. [Gorb, L.; Leszczynski, J.] Jackson State Univ, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA. [Gorb, L.] Badger Tech Serv LLC, Vicksburg, MS 39180 USA. [Hill, F.] US Army, Erdc, Vicksburg, MS 39180 USA. RP Ivashchenko, VI (reprint author), Natl Acad Sci Ukraine, Frantsevich Inst Mat Sci Problems, Vul Krzhizhanovskogo 3, UA-03680 Kiev, Ukraine. EM ivash@ipms.kiev.ua FU STCU [5539]; directorate of the Summery Institute at Jackson State University FX This work was partially supported by STCU Contract No. 5539. The authors are grateful to Dr. Timofejeva and Dr. Dub for XRD investigations and nanoindentation of the films. The authors are grateful to the directorate of the Summery Institute at Jackson State University for financial support and the possibility to perform large-scale calculations. NR 36 TC 2 Z9 2 U1 3 U2 20 PU ALLERTON PRESS INC PI NEW YORK PA 18 WEST 27TH ST, NEW YORK, NY 10001 USA SN 1063-4576 EI 1934-9408 J9 J SUPERHARD MATER+ JI J. Superhard Mater. PD NOV PY 2014 VL 36 IS 6 BP 381 EP 392 DI 10.3103/S1063457614060033 PG 12 WC Materials Science, Multidisciplinary SC Materials Science GA AX4PI UT WOS:000346913700003 ER PT J AU Vuyovich, CM Jacobs, JM Daly, SF AF Vuyovich, Carrie M. Jacobs, Jennifer M. Daly, Steven F. TI Comparison of passive microwave and modeled estimates of total watershed SWE in the continental United States SO WATER RESOURCES RESEARCH LA English DT Article ID EQUIVALENT RETRIEVAL ALGORITHMS; NORTHERN GREAT-PLAINS; SNOW DEPTH; WESTERN CANADA; IN-SITU; USA; UNCERTAINTY; AFGHANISTAN; RADIATION; BASINS AB In the U.S., a dedicated system of snow measurement stations and snowpack modeling products is available to estimate the snow water equivalent (SWE) throughout the winter season. In other regions of the world that depend on snowmelt for water resources, snow data can be scarce, and these regions are vulnerable to drought or flood conditions. Even in the U.S., water resource management is hampered by limited snow data in certain regions, as evident by the 2011 Missouri Basin flooding due in large part to the significant Plains snowpack. Satellite data could potentially provide important information in under-sampled areas. This study compared the daily AMSR-E and SSM/I SWE products over nine winter seasons to spatially distributed, modeled output SNODAS summed over 2100 watersheds in the conterminous U.S. Results show large areas where the passive microwave retrievals are highly correlated to the SNODAS data, particularly in the northern Great Plains and southern Rocky Mountain regions. However, the passive microwave SWE is significantly lower than SNODAS in heavily forested areas, and regions that typically receive a deep snowpack. The best correlations are associated with basins in which maximum annual SWE is less than 200 mm, and forest fraction is less than 20%. Even in many watersheds with poor correlations between the passive microwave data and SNODAS maximum annual SWE values, the overall pattern of accumulation and ablation did show good agreement and therefore may provide useful hydrologic information on melt timing and season length. C1 [Vuyovich, Carrie M.; Daly, Steven F.] Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Jacobs, Jennifer M.] Univ New Hampshire, Dept Civil Engn, Durham, NH 03824 USA. RP Vuyovich, CM (reprint author), Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. EM carrie.m.vuyovich@usace.army.mil FU NASA EPSCoR [NNX11AQ34A]; University of New Hampshire; U.S. Army Engineer Research and Development Center's Cold Regions Research and Engineering Laboratory FX This work was supported by a NASA EPSCoR grant NNX11AQ34A, the University of New Hampshire and the U.S. Army Engineer Research and Development Center's Cold Regions Research and Engineering Laboratory. We are grateful to Jeff Neihaus for his assistance in obtaining archived SNODAS data. We would like to thank Jeff Dozier, the associate editor, and two anonymous reviewers for their valuable feedback. All data used in this study are freely available and can be obtained by contacting the corresponding author. NR 52 TC 9 Z9 9 U1 1 U2 18 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0043-1397 EI 1944-7973 J9 WATER RESOUR RES JI Water Resour. Res. PD NOV PY 2014 VL 50 IS 11 BP 9088 EP 9102 DI 10.1002/2013WR014734 PG 15 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA AX0PQ UT WOS:000346654600039 ER PT J AU Brunye, TT Cantelon, J Holmes, A Taylor, HA Mahoney, CR AF Brunye, Tad T. Cantelon, Julie Holmes, Amanda Taylor, Holly A. Mahoney, Caroline R. TI Mitigating Cutaneous Sensation Differences During tDCS: Comparing Sham Versus Low Intensity Control Conditions SO BRAIN STIMULATION LA English DT Article DE Brain stimulation; Methodology; Cutaneous sensation; Inhibitory control ID DIRECT-CURRENT STIMULATION; MULTISOURCE INTERFERENCE TASK; TRANSCRANIAL DC STIMULATION; PREFRONTAL CORTEX; BRAIN-STIMULATION; MOTOR CORTEX; PERCEPTION; FMRI; EXCITABILITY; BEHAVIOR AB Background: Cutaneous sensations at electrode sites during the administration of direct current brain stimulation may inadvertently influence participants' subjective experience and task performance. Objective: The present study evaluated the utility of a methodological variation that substitutes sham administration with very low intensity (0.5 mA) current delivery. Methods: We used a 4 x 1 high-definition ring electrode transcranial direct current (HD-tDCS) system to target the left dorsolateral prefrontal cortex (Brodmann's Area 9). Four stimulation conditions were compared in a repeated-measures design: sham 2.0 mA and 0.5 mA intensity, versus active 2.0 mA and 0.5 mA intensity. During stimulation participants performed a cognitive interference task that activates the cingulo-frontal-parietal network, and periodically provided perceived sensation ratings. Results: We demonstrate that a relatively low intensity control condition attenuates otherwise large differences in perceived sensation between active and sham conditions. Critically, behavioral task differences maintained between the two active conditions. Conclusion: A low intensity control stimulation condition may prove a viable methodological alternative to conventional sham techniques used in repeated-measures designs, though important limitations are discussed. Published by Elsevier Inc. C1 [Brunye, Tad T.; Cantelon, Julie; Holmes, Amanda; Mahoney, Caroline R.] US Army, NSRDEC, RDNS SEW THC, Natick, MA 01760 USA. [Brunye, Tad T.; Cantelon, Julie; Holmes, Amanda; Taylor, Holly A.; Mahoney, Caroline R.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA. RP Brunye, TT (reprint author), US Army, NSRDEC, RDNS SEW THC, 15 Kansas St, Natick, MA 01760 USA. EM tbruny01@tufts.edu OI Brunye, Tad/0000-0002-8788-8764 NR 28 TC 4 Z9 4 U1 1 U2 8 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1935-861X EI 1876-4754 J9 BRAIN STIMUL JI Brain Stimul. PD NOV-DEC PY 2014 VL 7 IS 6 SI SI BP 832 EP 835 DI 10.1016/j.brs.2014.09.015 PG 4 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA AW7OZ UT WOS:000346455200010 PM 25444591 ER PT J AU Song, J Han, XG Gaskell, KJ Xu, K Lee, SB Hu, LB AF Song, Jaehee Han, Xiaogang Gaskell, Karen J. Xu, Kang Lee, Sang Bok Hu, Liangbing TI Enhanced electrochemical stability of high-voltage LiNi0.5Mn1.5O4 cathode by surface modification using atomic layer deposition SO JOURNAL OF NANOPARTICLE RESEARCH LA English DT Article DE Ultrathin coating Al2O3; Atomic layer deposition; LiNi0.5Mn1.5O4 nanoparticle; XPS investigation; Li-ion battery; Energy storage ID LITHIUM-ION BATTERIES; THIN-FILM; SPINEL; LICOO2; TEMPERATURE; PERFORMANCE; PROGRESS; CELLS; XPS AB We report improved cycling performance of high-voltage LiNi0.5Mn1.5O4 cathode for lithium-ion batteries by modifying its surface with ultrathin layer coating of Al2O3 (<1 nm) using atomic layer deposition (ALD) technique. Four and six layers of ALD Al2O3 were coated directly on the porous LiNi0.5Mn1.5O4 nanoparticle (similar to 200 nm) slurry composite. Electrochemical characterization results show that LiNi0.5Mn1.5O4 electrode with four and six layers of ALD Al2O3 maintained 92 and 98 % of their initial capacity after 200 cycles, respectively, in comparison to bare LiNi0.5Mn1.5O4 electrode which showed 84 % capacity retention. We show that the ALD Al2O3 coated cathode surface is protected from undesired side reactions occurring at the electrode/electrolyte interface. For the first time, we used XPS studies to investigate the surface chemistry of ultrathin ALD Al2O3 coated LiNi0.5Mn1.5O4 and confirmed that the ultrathin ALD Al2O3 layer reduces side reactions involving organic components of the electrolyte decomposition product in high-voltage cathodes. C1 [Song, Jaehee; Gaskell, Karen J.; Lee, Sang Bok] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA. [Han, Xiaogang; Lee, Sang Bok; Hu, Liangbing] Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA. [Xu, Kang] US Army Res Lab, Electrochem Branch, Power & Energy Div, Sensor & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Lee, SB (reprint author), Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA. EM slee@umd.edu; binghu@umd.edu RI Han, Xiaogang/D-6430-2015; Lee, Sang Bok/B-4421-2009; Hu, Liangbing/N-6660-2013 OI Han, Xiaogang/0000-0002-4785-6506; FU Nanostructures for Electrical Energy Storage (NEES), an Energy Frontier Research Centre (EFRC) - U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DESC0001160] FX This work was supported as part of the Nanostructures for Electrical Energy Storage (NEES), an Energy Frontier Research Centre (EFRC) funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences under Award Number DESC0001160. We also acknowledge the Maryland NanoCenter and its NispLab for use of SEM and TEM. NR 24 TC 3 Z9 3 U1 6 U2 81 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1388-0764 EI 1572-896X J9 J NANOPART RES JI J. Nanopart. Res. PD NOV PY 2014 VL 16 IS 11 AR 2745 DI 10.1007/s11051-014-2745-z PG 8 WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA AX1GX UT WOS:000346696900070 ER PT J AU Legree, PJ Psotka, J Robbins, J Roberts, RD Putka, DJ Mullins, HM AF Legree, Peter J. Psotka, Joseph Robbins, Jordan Roberts, Richard D. Putka, Dan J. Mullins, Heather M. TI Profile Similarity Metrics as an Alternate Framework to Score Rating-Based Tests: MSCEIT Reanalyses SO INTELLIGENCE LA English DT Article DE Profile Similarity Metrics; Emotional Intelligence; MSCEIT; Situational Judgment; Consensus Based Assessment ID SITUATIONAL JUDGMENT TESTS; EMOTIONAL INTELLIGENCE; TACIT KNOWLEDGE; SATISFACTION; PERFORMANCE; COMMITMENT; MODELS AB Profile similarity metrics provide an ideal framework to score rating-based judgment tests. These tests are distinct in asking subjects to rate the relative adequacy of multiple responses for each question. Respondent scores should be based on how well an individual's rating profile matches the answer key. However, respondents whose "rating-elevation" (tendency to give systematically low or high ratings) or "rating-scatter" (tendency to use more or less of the available scale) differs from the elevation and scatter of the scoring key can be given inappropriately low scores by distance-based algorithms. This can occur despite very high response accuracy with respect to the goal of correctly rating the relative adequacy of the response options for each question, "rating shape." Using this framework, reanalyses of MSCEIT data showed that after correcting scores for elevation and scatter effects, the MSCEIT is best described by a single factor that is highly g-loaded, (r = .79), not multiple factors with low g-loadings as hypothesized by its measurement model. These results demonstrate the importance of using profile similarity metrics (i.e., shape, elevation, and scatter) to evaluate the construct-related validity for rating-based judgment tests. Published by Elsevier Inc. C1 [Legree, Peter J.; Psotka, Joseph; Robbins, Jordan; Mullins, Heather M.] US Army Res Inst Behav & Social Sci, Ft Belvoir, VA 22026 USA. [Roberts, Richard D.] Profess Examinat Serv, New York, NY USA. [Putka, Dan J.] Human Resources Res Org, Alexandria, VA USA. RP Legree, PJ (reprint author), US Army Res Inst Behav & Social Sci, 6000 6th St Bldg 1464 Mail Stop 5610, Ft Belvoir, VA 22026 USA. EM Peter.J.Legree.Civ@Mail.Mil NR 27 TC 7 Z9 7 U1 2 U2 10 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0160-2896 EI 1873-7935 J9 INTELLIGENCE JI Intelligence PD NOV-DEC PY 2014 VL 47 BP 159 EP 174 DI 10.1016/j.intell.2014.09.005 PG 16 WC Psychology, Multidisciplinary SC Psychology GA AU9YR UT WOS:000345948400018 ER PT J AU Grumstrup, EM Gabriel, MM Pinion, CW Parker, JK Cahoon, JF Papanikolas, JM AF Grumstrup, Erik M. Gabriel, Michelle M. Pinion, Christopher W. Parker, James K. Cahoon, James F. Papanikolas, John M. TI Reversible Strain-Induced Electron-Hole Recombination in Silicon Nanowires Observed with Femtosecond Pump-Probe Microscopy SO NANO LETTERS LA English DT Article DE Ultrafast imaging; strained nanomaterials; spectroscopy ID ULTRAFAST CARRIER DYNAMICS; BENT ZNO MICROWIRES; SURFACE RECOMBINATION; CHARGE SEPARATION; MODULATION; SCATTERING; EMISSION; LIFETIME AB Strain-induced changes to the electronic structure of nanoscale materials provide a promising avenue for expanding the optoelectronic functionality of semiconductor nanostructures in device applications. Here we use pump-probe microscopy with femtosecond temporal resolution and submicron spatial resolution to characterize charge-carrier recombination and transport dynamics in silicon nanowires (NWs) locally strained by bending deformation. The electron-hole recombination rate increases with strain for values above a threshold of similar to 1% and, in highly strained (similar to 5%) regions of the NW, increases 6-fold. The changes in recombination rate are independent of NW diameter and reversible upon reduction of the applied strain, indicating the effect originates from alterations to the NW bulk electronic structure rather than introduction of defects. The results highlight the strong relationship between strain, electronic structure, and charge-carrier dynamics in low-dimensional semiconductor systems, and we anticipate the results will assist the development of strain-enabled optoelectronic devices with indirect-bandgap materials such as silicon. C1 [Grumstrup, Erik M.; Gabriel, Michelle M.; Pinion, Christopher W.; Cahoon, James F.; Papanikolas, John M.] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA. [Grumstrup, Erik M.; Parker, James K.] US Army Res Off, Div Chem Sci, Res Triangle Pk, NC 27709 USA. RP Grumstrup, EM (reprint author), Montana State Univ, Dept Chem & Biochem, Bozeman, MT 59717 USA. EM erik.grumstrup@montana.edu; jfcahoon@unc.edu; john_papanikolas@unc.edu FU National Science Foundation [CHE-1213379, DMR-1308695]; National Research Council - Army Research Office FX This project was supported by the National Science Foundation under grant numbers CHE-1213379 (E.M.G., M.M.G, and J.M.P) and DMR-1308695 (C.W.P. and J.F.C.). E.M.G. was supported by a National Research Council postdoctoral fellowship funded by the Army Research Office. NR 31 TC 8 Z9 8 U1 4 U2 38 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1530-6984 EI 1530-6992 J9 NANO LETT JI Nano Lett. PD NOV PY 2014 VL 14 IS 11 BP 6287 EP 6292 DI 10.1021/nl5026166 PG 6 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA AU6PE UT WOS:000345723800041 PM 25259929 ER PT J AU Wang, H Wang, XM Xia, FN Wang, LH Jiang, H Xia, QF Chin, ML Dubey, M Han, SJ AF Wang, Han Wang, Xiaomu Xia, Fengnian Wang, Luhao Jiang, Hao Xia, Qiangfei Chin, Matthew L. Dubey, Madan Han, Shu-jen TI Black Phosphorus Radio-Frequency Transistors SO NANO LETTERS LA English DT Article DE Black phosphorus; phosphorene; radio frequency; transistor; 2D materials; graphene ID THIN-FILM TRANSISTORS; FIELD-EFFECT TRANSISTORS; GRAPHENE TRANSISTORS; GIGAHERTZ FREQUENCIES; ELECTRONICS; FT AB Few-layer and thin film forms of layered black phosphorus (BP) have recently emerged as a promising material for applications in high performance nanoelectronics and infrared optoelectronics. Layered BP thin films offer a moderate bandgap of around 0.3 eV and high carrier mobility, which lead to transistors with decent onoff ratios and high on-state current densities. Here, we demonstrate the gigahertz frequency operation of BP field-effect transistors for the first time. The BP transistors demonstrated here show respectable current saturation with an onoff ratio that exceeds 2 x 10(3). We achieved a current density in excess of 270 mA/mm and DC transconductance above 180 mS/mm for hole conduction. Using standard high frequency characterization techniques, we measured a short-circuit current-gain cutoff frequency f(T) of 12 GHz and a maximum oscillation frequency f(max) of 20 GHz in 300 nm channel length devices. BP devices may offer advantages over graphene transistors for high frequency electronics in terms of voltage and power gain due to the good current saturation properties arising from their finite bandgap, thus can be considered as a promising candidate for the future high performance thin film electronics technology for operation in the multi-GHz frequency range and beyond. C1 [Wang, Han; Wang, Luhao] Univ So Calif, Ming Hsieh Dept Elect Engn, Los Angeles, CA 90089 USA. [Wang, Xiaomu; Xia, Fengnian] Yale Univ, Dept Elect Engn, New Haven, CT 06511 USA. [Jiang, Hao; Xia, Qiangfei] Univ Massachusetts, Dept Elect & Comp Engn, Amherst, MA 01003 USA. [Chin, Matthew L.; Dubey, Madan] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20723 USA. [Han, Shu-jen] IBM TJ Watson Res Ctr, Yorktown Hts, NY 10598 USA. RP Wang, H (reprint author), Univ So Calif, Ming Hsieh Dept Elect Engn, Los Angeles, CA 90089 USA. EM han.wang.4@usc.edu; fengnian.xia@yale.edu RI Xia, Fengnian/O-2637-2015; Wang, Xiaomu/Q-8638-2016 OI Xia, Fengnian/0000-0001-5176-368X; FU Army Research Laboratory (ARL); Office of Naval Research (ONR); US Air Force Office of Scientific Research (AFOSR) through a MURI grant FX We thank T.-P. Ma at Yale University for the stimulating discussions on the transistor performance. We thank M. Dresselhaus at MIT for the valuable discussions on BP properties. We would like to thank Y. Jia at Yale University for assistance in the measurement of the infrared extinction spectra of BP flakes. We acknowledge W. Haensch and S. Guha at IBM for their support of this work. H.W. acknowledges support from the Army Research Laboratory (ARL). F.X. acknowledges support from the Office of Naval Research (ONR). H.J. and Q.X. are partially supported by the US Air Force Office of Scientific Research (AFOSR) through a MURI grant. NR 42 TC 98 Z9 98 U1 13 U2 176 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1530-6984 EI 1530-6992 J9 NANO LETT JI Nano Lett. PD NOV PY 2014 VL 14 IS 11 BP 6424 EP 6429 DI 10.1021/nl5029717 PG 6 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA AU6PE UT WOS:000345723800062 PM 25347787 ER PT J AU Quinn, MCL Taylor, ODS AF Quinn, Meghan C. L. Taylor, Oliver-Denzil S. TI Hazard Topography: Visual Approach for Identifying Critical Failure Combinations for Infrastructure SO NATURAL HAZARDS REVIEW LA English DT Article DE Natural disasters; Slope stability; Finite element method; Public safety ID EARTH DAMS AB Infrastructure catastrophes, such as the levee failure during Hurricane Katrina and the Fukashima nuclear disaster, are often triggered by a critical combination of events. Typically, engineers evaluate the risk of failure of infrastructure for a single probabilistic combination of events. This paper focuses on a visual multihazard evaluation method to evaluate infrastructure stability and critical hazard combinations. To present this method, the authors considered the multihazard stability of a flood control earth embankment, evaluated by calculating a factor of safety (FS). Multihazard topography promotes the comparison of design/repair options with stability and two other variables that affect stability. This evaluation tool will assist engineers, owners, and regulatory agencies in the best design or best mitigation evaluation process (for both cost and hazard reduction). (C) 2014 American Society of Civil Engineers. C1 [Quinn, Meghan C. L.] US Army Corps Engn, Concord, MA 01742 USA. [Taylor, Oliver-Denzil S.] US Army Engn Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. RP Quinn, MCL (reprint author), US Army Corps Engn, Concord, MA 01742 USA. EM meghan.c.quinn@usace.army.mil; oliver.d.taylor@usace.army.mil FU Geotechnical and Structures Laboratory, Engineer Research and Development Center FX Research funding and permission to publish was granted by Director, Geotechnical and Structures Laboratory, Engineer Research and Development Center, and the report is approved for public release; distribution is unlimited. NR 22 TC 2 Z9 2 U1 4 U2 16 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1527-6988 EI 1527-6996 J9 NAT HAZARDS REV JI Nat. Hazards Rev. PD NOV PY 2014 VL 15 IS 4 AR 04014012 DI 10.1061/(ASCE)NH.1527-6996.0000131 PG 13 WC Engineering, Civil; Environmental Studies; Geosciences, Multidisciplinary; Meteorology & Atmospheric Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Geology; Meteorology & Atmospheric Sciences; Water Resources GA AU6XH UT WOS:000345744200005 ER PT J AU Warren, TK Trefry, JC Marko, ST Chance, TB Wells, JB Pratt, WD Johnson, JC Mucker, EM Norris, SL Chappell, M Dye, JM Honko, AN AF Warren, Travis K. Trefry, John C. Marko, Shannon T. Chance, Taylor B. Wells, Jay B. Pratt, William D. Johnson, Joshua C. Mucker, Eric M. Norris, Sarah L. Chappell, Mark Dye, John M. Honko, Anna N. TI Euthanasia Assessment in Ebola Virus Infected Nonhuman Primates SO VIRUSES-BASEL LA English DT Article DE filovirus; nonhuman primate; viral hemorrhagic fever; euthanasia; clinical pathology; Ebola virus ID POSTEXPOSURE PROTECTION; HEMORRHAGIC-FEVER; RHESUS-MONKEYS; DISEASE; CHALLENGE AB Multiple products are being developed for use against filoviral infections. Efficacy for these products will likely be demonstrated in nonhuman primate models of filoviral disease to satisfy licensure requirements under the Animal Rule, or to supplement human data. Typically, the endpoint for efficacy assessment will be survival following challenge; however, there exists no standardized approach for assessing the health or euthanasia criteria for filovirus-exposed nonhuman primates. Consideration of objective criteria is important to (a) ensure test subjects are euthanized without unnecessary distress; (b) enhance the likelihood that animals exhibiting mild or moderate signs of disease are not prematurely euthanized; (c) minimize the occurrence of spontaneous deaths and loss of end-stage samples; (d) enhance the reproducibility of experiments between different researchers; and (e) provide a defensible rationale for euthanasia decisions that withstands regulatory scrutiny. Historic records were compiled for 58 surviving and non-surviving monkeys exposed to Ebola virus at the US Army Medical Research Institute of Infectious Diseases. Clinical pathology parameters were statistically analyzed and those exhibiting predicative value for survival are reported. These findings may be useful for standardization of objective euthanasia assessments in rhesus monkeys exposed to Ebola virus and may serve as a useful approach for other standardization efforts. C1 [Warren, Travis K.; Trefry, John C.; Marko, Shannon T.; Chance, Taylor B.; Wells, Jay B.; Pratt, William D.; Johnson, Joshua C.; Mucker, Eric M.; Norris, Sarah L.; Chappell, Mark; Dye, John M.; Honko, Anna N.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Marko, Shannon T.] Madigan Army Med Ctr, Tacoma, WA 98431 USA. [Johnson, Joshua C.; Honko, Anna N.] NIAID, Integrated Res Facil, Ft Detrick, MD 21702 USA. [Chappell, Mark] Armed Forces Radiobiol Res Inst, Bethesda, MD 20889 USA. RP Warren, TK (reprint author), US Army, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM travis.k.warren.ctr@mail.mil; john.c.trefry.ctr@mail.mil; shannon.t.marko.mil@mail.mil; taylor.b.chance.mil@mail.mil; jay.b.wells.ctr@mail.mil; william.d.pratt4.civ@mail.mil; joshua.johnson@nih.gov; eric.m.mucker.ctr@mail.mil; sarah.l.norris2.civ@mail.mil; mark.chappell@usuhs.edu; john.m.dye1.civ@mail.mil; anna.honko@nih.gov OI Johnson, Joshua/0000-0002-5677-3841; Honko, Anna/0000-0001-9165-148X FU Defense Threat Reduction Agency FX Financial contributions for this work were provided in part by the Defense Threat Reduction Agency. The authors acknowledge the contributions of the numerous individuals who participated in the historic nonhuman primate evaluations described in this report. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. Research was conducted under an IACUC approved protocol in compliance with the Animal Welfare Act, PHS Policy, and other Federal statutes and regulations relating to animals and experiments involving animals. The facility where this research was conducted is accredited by the Association for Assessment and Accreditation of Laboratory Animal Care, International and adheres to principles stated in the Guide for the Care and Use of Laboratory Animals, National Research Council, 2011. NR 22 TC 6 Z9 6 U1 0 U2 11 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1999-4915 J9 VIRUSES-BASEL JI Viruses-Basel PD NOV PY 2014 VL 6 IS 11 BP 4666 EP 4682 DI 10.3390/v6114666 PG 17 WC Virology SC Virology GA AU4FL UT WOS:000345565200031 PM 25421892 ER PT J AU Kuhn, JH Andersen, KG Baize, S Bao, YM Bavari, S Berthet, N Blinkova, O Brister, JR Clawson, AN Fair, J Gabriel, M Garry, RF Gire, SK Goba, A Gonzalez, JP Gunther, S Happi, CT Jahrling, PB Kapetshi, J Kobinger, G Kugelman, JR Leroy, EM Maganga, GD Mbala, PK Moses, LM Muyembe-Tamfum, JJ N'Faly, M Nichol, ST Omilabu, SA Palacios, G Park, DJ Paweska, JT Radoshitzky, SR Rossi, CA Sabeti, PC Schieffelin, JS Schoepp, RJ Sealfon, R Swanepoel, R Towner, JS Wada, J Wauquier, N Yozwiak, NL Formenty, P AF Kuhn, Jens H. Andersen, Kristian G. Baize, Sylvain Bao, Yiming Bavari, Sina Berthet, Nicolas Blinkova, Olga Brister, J. Rodney Clawson, Anna N. Fair, Joseph Gabriel, Martin Garry, Robert F. Gire, Stephen K. Goba, Augustine Gonzalez, Jean-Paul Guenther, Stephan Happi, Christian T. Jahrling, Peter B. Kapetshi, Jimmy Kobinger, Gary Kugelman, Jeffrey R. Leroy, Eric M. Maganga, Gael Darren Mbala, Placide K. Moses, Lina M. Muyembe-Tamfum, Jean-Jacques N'Faly, Magassouba Nichol, Stuart T. Omilabu, Sunday A. Palacios, Gustavo Park, Daniel J. Paweska, Janusz T. Radoshitzky, Sheli R. Rossi, Cynthia A. Sabeti, Pardis C. Schieffelin, John S. Schoepp, Randal J. Sealfon, Rachel Swanepoel, Robert Towner, Jonathan S. Wada, Jiro Wauquier, Nadia Yozwiak, Nathan L. Formenty, Pierre TI Nomenclature- and Database-Compatible Names for the Two Ebola Virus Variants that Emerged in Guinea and the Democratic Republic of the Congo in 2014 SO VIRUSES-BASEL LA English DT Article DE Ebola; Ebola virus; ebolavirus; filovirid; Filoviridae; filovirus; genome annotation; Lomela; Lokolia; Makona; mononegavirad; Mononegavirales; mononegavirus; virus classification; virus isolate; virus nomenclature; virus strain; virus taxonomy; virus variant ID INTERNATIONAL COMMITTEE; TAXONOMIC PROPOSALS; FAMILY FILOVIRIDAE; RATIFICATION VOTE AB In 2014, Ebola virus (EBOV) was identified as the etiological agent of a large and still expanding outbreak of Ebola virus disease (EVD) in West Africa and a much more confined EVD outbreak in Middle Africa. Epidemiological and evolutionary analyses confirmed that all cases of both outbreaks are connected to a single introduction each of EBOV into human populations and that both outbreaks are not directly connected. Coding-complete genomic sequence analyses of isolates revealed that the two outbreaks were caused by two novel EBOV variants, and initial clinical observations suggest that neither of them should be considered strains. Here we present consensus decisions on naming for both variants (West Africa: "Makona", Middle Africa: "Lomela") and provide database-compatible full, shortened, and abbreviated names that are in line with recently established filovirus sub-species nomenclatures. C1 [Kuhn, Jens H.; Clawson, Anna N.; Jahrling, Peter B.; Wada, Jiro] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD 21702 USA. [Andersen, Kristian G.; Gire, Stephen K.; Sabeti, Pardis C.; Yozwiak, Nathan L.] Harvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA. [Baize, Sylvain] Inst Pasteur, Unite Biol Infect Virales Emergentes, Lyon, France. [Baize, Sylvain] Univ Lyon 1, CNRS, Ecole Normale Super Lyon, CIRI,INSERM,U1111,UMR5308, F-69365 Lyon, France. [Bao, Yiming; Blinkova, Olga; Brister, J. Rodney] NIH, Informat Engn Branch, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20894 USA. [Bavari, Sina; Kugelman, Jeffrey R.; Palacios, Gustavo; Radoshitzky, Sheli R.; Rossi, Cynthia A.; Schoepp, Randal J.] US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Berthet, Nicolas; Leroy, Eric M.; Maganga, Gael Darren] Ctr Int Rech Med Franceville, Franceville, Gabon. [Fair, Joseph] Fdn Merieux, Washington, DC 20036 USA. [Gabriel, Martin; Guenther, Stephan] WHO, Bernhard Nocht Inst Trop Med, Collaborating Ctr Arbovirus & Hemorrhag Fever Ref, D-20259 Hamburg, Germany. [Gabriel, Martin; Guenther, Stephan] German Ctr Infect Res DZIF, D-20259 Hamburg, Germany. [Garry, Robert F.; Moses, Lina M.; Schieffelin, John S.] Tulane Univ, Sch Med, New Orleans, LA 70112 USA. [Goba, Augustine] Kenema Govt Hosp, Kenema, Sierra Leone. [Gonzalez, Jean-Paul; Wauquier, Nadia] Metabiota Inc, San Francisco, CA 94104 USA. [Happi, Christian T.] Redeemers Univ, Coll Nat Sci, Dept Biol Sci, Mowe, Ogun State, Nigeria. [Happi, Christian T.] Redeemers Univ, African Ctr Excellence Genom Infect Dis, Mowe, Ogun State, Nigeria. [Kobinger, Gary] Publ Hlth Agcy Canada, Natl Microbiol Lab, Special Pathogens Program, Winnipeg, MB R3E 3R2, Canada. [N'Faly, Magassouba] Univ Gamal Abdel Nasser de Conakry, Lab Fievres Hemorrag Guinee, Hop Natl Donka, Serv Malad Infect & Trop, Conakry, Guinea. [Nichol, Stuart T.; Towner, Jonathan S.] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div High Consequence Pathogens & Pathol, Viral Special Pathogens Branch, Atlanta, GA 30333 USA. [Omilabu, Sunday A.] Univ Lagos, Coll Med, Dept Med Microbiol & Parasitol, Lagos, Nigeria. [Park, Daniel J.] Broad Inst, Cambridge, MA 02142 USA. [Paweska, Janusz T.] Natl Hlth Lab Serv, Natl Inst Communicable Dis, Ctr Emerging & Zoonot Dis, ZA-2192 Sandringham Johannesburg, Gauteng, South Africa. [Sealfon, Rachel] MIT, Comp Sci & Artificial Intelligence Lab, Cambridge, MA 02139 USA. [Swanepoel, Robert] Univ Pretoria, Zoonoses Res Unit, ZA-0028 Pretoria, South Africa. [Formenty, Pierre] WHO, CH-1211 Geneva, Switzerland. RP Kuhn, JH (reprint author), NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD 21702 USA. EM kuhnjens@mail.nih.gov; kandersen@oeb.harvard.edu; sylvain.baize@inserm.fr; bao@ncbi.nlm.nih.gov; sina.bavari.civ@mail.mil; nicolas.berthet@pasteur.fr; olga.blinkova@nih.gov; jamesbr@ncbi.nlm.nih.gov; anna@logosconsulting.us; joseph.fair@fondation-merieux.org; gabriel@bni-hamburg.de; rfgarry@tulane.edu; sgire@oeb.harvard.edu; augstgoba@yahoo.com; jpgonzalez@metabiota.com; guenther@bni.uni-hamburg.de; happic@run.edu.ng; jahrlingp@niaid.nih.gov; jimmy_kap@hotmail.com; gary.kobinger@phac-aspc.gc.ca; jeffrey.r.kugelman.mil@mail.mil; eric.leroy@ird.fr; gael_maganga@yahoo.fr; mbalaplacide@gmail.com; lmoses2@tulane.edu; muyembejj@gmail.com; cmagassouba01@gmail.com; stn1@cdc.gov; omilabusa@yahoo.com; gustavo.f.palacios.ctr@us.army.mil; dpark@broadinstitute.org; januszp@nicd.ac.za; sheli.r.radoshitzky.ctr@mail.mil; cynthia.a.rossi.civ@mail.mil; pardis@broadinstitute.org; jschieff@tulane.edu; randal.j.schoepp.civ@mail.mil; sealfon@gmail.com; bobswanepoel@gmail.com; jit8@cdc.gov; wadaj@niaid.nih.gov; nadia.wauquier@gmail.com; nyozwiak@broadinstitute.org; formentyp@who.int RI Berthet, Nicolas/J-9373-2012; Kuhn, Jens H./B-7615-2011; Palacios, Gustavo/I-7773-2015; LEROY, Eric/I-4347-2016 OI Kuhn, Jens H./0000-0002-7800-6045; Palacios, Gustavo/0000-0001-5062-1938; LEROY, Eric/0000-0003-0022-0890 FU Battelle Memorial Institute; US National Institute of Allergy and Infectious Diseases (NIAID) [HHSN272200700016I]; Intramural Research Program of the NIH, National Library of Medicine FX We thank Laura Bollinger (IRF-Frederick) for carefully editing the manuscript. The content of this publication does not necessarily reflect the views or policies of the US Department of Health and Human Services (DHHS) or of the institutions and companies affiliated with the authors. This work was funded in part through Battelle Memorial Institute's prime contract with the US National Institute of Allergy and Infectious Diseases (NIAID) under Contract No. HHSN272200700016I. J.W. performed this work as an employee of Battelle Memorial Institute. Subcontractors to Battelle Memorial Institute who performed this work are: J.H.K., an employee of Tunnell Government Services, Inc. This research was further supported in part by the Intramural Research Program of the NIH, National Library of Medicine (Y.B., O.B., and J.R.B.). NR 22 TC 39 Z9 41 U1 3 U2 29 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1999-4915 J9 VIRUSES-BASEL JI Viruses-Basel PD NOV PY 2014 VL 6 IS 11 BP 4760 EP 4799 DI 10.3390/v6114760 PG 40 WC Virology SC Virology GA AU4FL UT WOS:000345565200035 PM 25421896 ER PT J AU Biddle, TD AF Biddle, Tami Davis TI The Bombing War: Europe, 1939-1945 SO WAR IN HISTORY LA English DT Book Review C1 [Biddle, Tami Davis] US Army War Coll, Carlisle, PA USA. RP Biddle, TD (reprint author), US Army War Coll, Carlisle, PA USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0968-3445 EI 1477-0385 J9 WAR HIST JI War Hist. PD NOV PY 2014 VL 21 IS 4 BP 553 EP 555 PG 3 WC History; International Relations SC History; International Relations GA AU6RX UT WOS:000345730600024 ER PT J AU Richardson, L Keefe, K Huber, C Racevskis, L Reynolds, G Thourot, S Miller, I AF Richardson, Leslie Keefe, Kelly Huber, Christopher Racevskis, Laila Reynolds, Gregg Thourot, Scott Miller, Ian TI Assessing the value of the Central Everglades Planning Project (CEPP) in Everglades restoration: An ecosystem service approach SO ECOLOGICAL ECONOMICS LA English DT Article DE Ecosystem services; Nonmarket valuation; Peat accretion; Carbon sequestration; Comprehensive Everglades Restoration Plan (CERP); Central Everglades Planning Project (CEPP); Benefit transfer ID CONCEPTUAL ECOLOGICAL MODEL; CALOOSAHATCHEE-ESTUARY; AGRICULTURAL AREA; SOUTH FLORIDA; ORGANIC SOILS; WATER-QUALITY; NATIONAL-PARK; FIRE REGIMES; PINK SHRIMP; SUBSIDENCE AB This study identifies a full range of ecosystem services that could be affected by a restoration project in the central Everglades and monetizes the economic value of a subset of these services using existing data. Findings suggest that the project will potentially increase many ecosystem services that have considerable economic value to society. The ecosystem services monetized within the scope of this study are a subset of the difference between the future-with the Central Everglades Planning Project (CEPP) and the future-without CEPP, and they totaled similar to $1.8 billion USD at a 2.5% discount rate. Findings suggest that the use of ecosystem services in project planning and communications may require acknowledgment of the difficulty of monetizing important services and the limitations associated with using only existing data and models. Results of this study highlight the need for additional valuation efforts in this region, focused on those services that are likely to be impacted by restoration activities but were notably challenging to value in this assessment due to shortages of data. Published by Elsevier B.V. C1 [Richardson, Leslie; Huber, Christopher] US Geol Survey, Ft Collins Sci Ctr, Ft Collins, CO 80526 USA. [Keefe, Kelly] US Army Corps Engineers, Cent Everglades Branch, Jacksonville, FL 32217 USA. [Racevskis, Laila] Univ Florida, Food & Resource Econ Dept, Gainesville, FL 32611 USA. [Reynolds, Gregg] South Florida Ecosyst Off, Everglades Natl Pk, Natl Pk Serv, Homestead, FL 33030 USA. [Thourot, Scott; Miller, Ian] South Florida Water Management Dist, W Palm Beach, FL 33406 USA. RP Richardson, L (reprint author), US Geol Survey, Ft Collins Sci Ctr, 2150 Ctr Ave,Bldg C, Ft Collins, CO 80526 USA. EM lrichardson@usgs.gov; KellyJ.Keefe@usace.army.mil; chuber@usgs.gov; gregg_reynolds@nps.gov; sthourot@sfwmd.gov; imiller@sfwmd.gov FU U.S. Army Corps of Engineers; South Florida Water Management District FX This work was funded by cost sharing between the U.S. Army Corps of Engineers and the South Florida Water Management District within the Comprehensive Everglades Restoration Plan. In addition to the two anonymous peer reviewers who provided very insightful comments, this work benefitted tremendously from the following contributors and reviewers: Rick Anderson, Joan Browder, Eric Bush, David Crane, Janet Cushing, Vic Engel, Jason Godin, Patti Gorman, Chris Kelble, Jerry Krenz, Agnes McLean, Christopher McVoy, Max Millstein, Barron Moody, Matt Morrison, Elizabeth Murray, Sashi Nair, Melissa Nasuti, Todd Osborne, Leonard Pearlstine, Marshall Plumley, K. Ramesh Reddy, Jed Redwine, Stephanie Romanach, Paul Scodari, Liberta Scotto, Tom Teets, Kim Taplin, Steve Traxler, Lisa Wainger, Harden Waddle, Walter Wilcox, and Kevin Wittmann. Any errors or omissions are those of the authors alone. NR 94 TC 1 Z9 1 U1 5 U2 40 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0921-8009 EI 1873-6106 J9 ECOL ECON JI Ecol. Econ. PD NOV PY 2014 VL 107 BP 366 EP 377 DI 10.1016/j.ecolecon.2014.09.011 PG 12 WC Ecology; Economics; Environmental Sciences; Environmental Studies SC Environmental Sciences & Ecology; Business & Economics GA AU2WG UT WOS:000345474800035 ER PT J AU Zhao, Y Strope, PK Kozmin, SG McCusker, JH Dietrich, FS Kokoska, RJ Petes, TD AF Zhao, Ying Strope, Pooja K. Kozmin, Stanislav G. McCusker, John H. Dietrich, Fred S. Kokoska, Robert J. Petes, Thomas D. TI Structures of Naturally Evolved CUP1 Tandem Arrays in Yeast Indicate That These Arrays Are Generated by Unequal Nonhomologous Recombination SO G3-GENES GENOMES GENETICS LA English DT Article DE copper resistance; tandemly repeated genes; recombination; Saccharomyces cerevisiae ID COPY-NUMBER VARIATION; SACCHAROMYCES-CEREVISIAE; GENE AMPLIFICATION; DNA-REPLICATION; COPPER RESISTANCE; RIBOSOMAL DNA; REARRANGEMENTS; TRANSCRIPTION; EVOLUTION; SEQUENCE AB An important issue in genome evolution is the mechanism by which tandem duplications are generated from single-copy genes. In the yeast Saccharomyces cerevisiae, most strains contain tandemly duplicated copies of CUP1, a gene that encodes a copper-binding metallothionein. By screening 101 natural isolates of S. cerevisiae, we identified five different types of CUP1-containing repeats, as well as strains that only had one copy of CUP1. A comparison of the DNA sequences of these strains indicates that the CUP1 tandem arrays were generated by unequal nonhomologous recombination events from strains that had one CUP1 gene. C1 [Zhao, Ying; Strope, Pooja K.; Kozmin, Stanislav G.; McCusker, John H.; Dietrich, Fred S.; Petes, Thomas D.] Duke Univ, Dept Mol Genet & Microbiol, Med Ctr, Durham, NC 27710 USA. [Zhao, Ying; Strope, Pooja K.; Kozmin, Stanislav G.; McCusker, John H.; Dietrich, Fred S.; Petes, Thomas D.] Duke Univ, Univ Program Genet & Genom, Med Ctr, Durham, NC 27710 USA. [Kokoska, Robert J.] US Army Res Off, Phys Sci Directorate, Res Triangle Pk, NC 27709 USA. RP Petes, TD (reprint author), Duke Univ, Dept Mol Genet & Microbiol, Med Ctr, 213 Res Dr, Durham, NC 27710 USA. EM tom.petes@duke.edu FU National Institutes of Health [GM24110, GM52319, GM098287, T32 AI052080]; Army Research Office (SPS) [200531] FX We thank D. Thiel for the yeast strain DTY3, and Y. Yin, S. Andersen, and S. Jinks-Robertson for comments on the manuscript. The research was supported by National Institutes of Health grants GM24110 and GM52319 to T. P. and GM098287 to J.H.M. Y.Z. and P. K. S. were supported by grants from the Army Research Office (SPS #200531), and the National Institutes of Health (T32 AI052080), respectively. NR 39 TC 8 Z9 8 U1 1 U2 3 PU GENETICS SOCIETY AMERICA PI BETHESDA PA 9650 ROCKVILLE AVE, BETHESDA, MD 20814 USA SN 2160-1836 J9 G3-GENES GENOM GENET JI G3-Genes Genomes Genet. PD NOV 1 PY 2014 VL 4 IS 11 BP 2259 EP 2269 DI 10.1534/g3.114.012922 PG 11 WC Genetics & Heredity SC Genetics & Heredity GA AU0BR UT WOS:000345288700021 PM 25236733 ER PT J AU Kim, Y Mohan, S Siegel, JB Stefanopoulou, AG Ding, Y AF Kim, Youngki Mohan, Shankar Siegel, Jason B. Stefanopoulou, Anna G. Ding, Yi TI The Estimation of Temperature Distribution in Cylindrical Battery Cells Under Unknown Cooling Conditions SO IEEE TRANSACTIONS ON CONTROL SYSTEMS TECHNOLOGY LA English DT Article DE Dual Kalman filter (DKF); lithium ion (Li-ion) batteries; reduced-order model; state and parameter estimation; thermal modeling ID LITHIUM-ION BATTERY; THERMAL-ANALYSIS; PERFORMANCE; MODEL; ELECTRODE; BEHAVIOR; CYCLE AB The estimation of temperature inside a battery cell requires accurate information about the cooling conditions even when the battery surface temperature is measured. This paper presents a model-based approach for estimating temperature distribution inside a cylindrical battery under unknown convective cooling conditions. A reduced-order thermal model using a polynomial approximation of the temperature profile inside the battery is used. A dual Kalman filter (DKF), a combination of a Kalman filter and an extended Kalman filter, is then applied for the identification of the convection coefficient and the estimation of the battery core temperature. The thermal properties are modeled by volume averaged lumped-values under the assumption of a homogeneous and isotropic volume. The model is parameterized and validated using experimental data from a 2.3 Ah 26 650 lithium-iron-phosphate battery cell with a forced-air convective cooling during hybrid electric vehicle drive cycles. Experimental results show that the proposed DKF-based estimation method can provide an accurate prediction of the core temperature under unknown cooling conditions by measuring battery current and voltage along with surface and ambient temperatures. C1 [Kim, Youngki; Siegel, Jason B.; Stefanopoulou, Anna G.] Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA. [Mohan, Shankar] Univ Michigan, Dept Elect Engn, Ann Arbor, MI 48109 USA. [Ding, Yi] US Army Tank Automot Res Dev & Engn Ctr, Warren, MI 48397 USA. RP Kim, Y (reprint author), Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA. EM youngki@umich.edu; elemsn@umich.edu; siegeljb@umich.edu; annastef@umich.edu; yi.ding8.civ@mail.mil OI Mohan, Shankar/0000-0002-6107-7672 FU Automotive Research Center [W56HZV-04-2-0001]; U.S. Army Tank Automotive Research, Development and Engineering Center, Warren, MI, USA FX This work was supported in part by the Automotive Research Center through the Cooperative Agreement under Grant W56HZV-04-2-0001 and in part by the U.S. Army Tank Automotive Research, Development and Engineering Center, Warren, MI, USA. Recommended by Associate Editor S. Varigonda. NR 31 TC 21 Z9 21 U1 2 U2 20 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1063-6536 EI 1558-0865 J9 IEEE T CONTR SYST T JI IEEE Trans. Control Syst. Technol. PD NOV PY 2014 VL 22 IS 6 BP 2277 EP 2286 DI 10.1109/TCST.2014.2309492 PG 10 WC Automation & Control Systems; Engineering, Electrical & Electronic SC Automation & Control Systems; Engineering GA AU4JH UT WOS:000345576300016 ER PT J AU Wildman, RA Gazonas, GA AF Wildman, Raymond A. Gazonas, George A. TI A finite difference-augmented peridynamics method for reducing wave dispersion SO INTERNATIONAL JOURNAL OF FRACTURE LA English DT Article DE Finite difference; Peridynamics; Fracture; Wave propagation ID TRANSIENT HEAT-CONDUCTION; LONG-RANGE FORCES; MAXWELLS EQUATIONS; ADAPTIVE REFINEMENT; NUMERICAL-SOLUTION; ELASTIC-WAVES; PROPAGATION; MEDIA; MECHANICS; SCHEME AB A method is presented for the modeling of brittle elastic fracture which combines peridynamics and a finite difference method to mitigate the wave dispersion properties of peridynamics. Essentially, a finite difference method is used in the bulk for wave propagation modeling, while peridynamics is automatically inserted in high strain areas to model crack initiation and growth. The dispersion properties of finite difference methods and discretized peridynamics are reviewed and the interface reflection properties between the two regions are investigated. Results show that the augmented method can improve the modeling of wave propagation and boundary conditions. In addition, the numerical stress intensity factor computed at a crack tip shows reduced oscillations in the augmented method, likely due to the improved dispersion properties of the bulk. Dynamic fracture simulations show a difference in crack paths between the methods. C1 [Wildman, Raymond A.; Gazonas, George A.] US Army Res Lab, Attn RDRL WMM B, Aberdeen, MD 21005 USA. RP Wildman, RA (reprint author), US Army Res Lab, Attn RDRL WMM B, Aberdeen, MD 21005 USA. EM raymond.a.wildman.civ@mail.mil OI Gazonas, George/0000-0002-2715-016X NR 32 TC 4 Z9 4 U1 2 U2 6 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0376-9429 EI 1573-2673 J9 INT J FRACTURE JI Int. J. Fract. PD NOV PY 2014 VL 190 IS 1-2 BP 39 EP 52 DI 10.1007/s10704-014-9973-1 PG 14 WC Materials Science, Multidisciplinary; Mechanics SC Materials Science; Mechanics GA AU1WR UT WOS:000345408700003 ER PT J AU Reiter, MJ Schwope, RB Kini, JA York, GE Theler, JM AF Reiter, Michael J. Schwope, Ryan B. Kini, Jonathan A. York, Gerald E. Theler, Jared M. TI Computed Tomography Imaging Manifestations of Commonly Used Materials in Posttraumatic Craniofacial Repair SO JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY LA English DT Review DE bone graft; alloplast; craniofacial; trauma; CT ID BONE-GRAFT MATERIALS; ORBITAL IMPLANTS; BIOMATERIALS; RECONSTRUCTION; SUBSTITUTES AB An expansive array of materials exists within the armamentarium of craniofacial surgeons. For patients undergoing repair of posttraumatic injuries, computed tomography is the imaging modality of choice in the postoperative setting. Therefore, radiologists will invariably encounter implants constructed with various materials, depending on the surgeon's preference. The appearance of these materials on computed tomography is broad, ranging from hyperdense to radiolucent. To avoid misdiagnosis, radiologists should be familiar with all of the materials currently in use. C1 [Reiter, Michael J.; Schwope, Ryan B.; Kini, Jonathan A.; York, Gerald E.] Brooke Army Med Ctr, Dept Radiol, San Antonio, TX 78234 USA. [Reiter, Michael J.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Theler, Jared M.] Brooke Army Med Ctr, Dept Otolaryngol, San Antonio, TX 78234 USA. RP Reiter, MJ (reprint author), Brooke Army Med Ctr, Dept Radiol, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA. EM mikereiter13@yahoo.com NR 20 TC 1 Z9 1 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0363-8715 EI 1532-3145 J9 J COMPUT ASSIST TOMO JI J. Comput. Assist. Tomogr. PD NOV-DEC PY 2014 VL 38 IS 6 BP 890 EP 897 PG 8 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA AU2EW UT WOS:000345430200014 PM 25119065 ER EF