FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Pavliscsak, H Little, JR Poropatich, RK McVeigh, FL Tong, J Tillman, JS Smith, CH Fonda, SJ AF Pavliscsak, Holly Little, Jeanette R. Poropatich, Ronald K. McVeigh, Francis L. Tong, James Tillman, Johnie S. Smith, Challis H. Fonda, Stephanie Jo TI Assessment of patient engagement with a mobile application among service members in transition SO JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION LA English DT Article DE case management; traumatic brain injury; post-traumatic stress disorder; mobile health; patient engagement ID MANAGEMENT; PROGRAM; INTERVENTIONS; EMPOWERMENT; OUTCOMES; PHONES; MODEL; CARE AB Objective: This article examines engagement with a mobile application ("mCare") for wounded Service Members rehabilitating in their communities. Many had behavioral health problems, Traumatic Brain Injury (TBI), and/or post-traumatic stress disorder (PTS). The article also examines associations between Service Members' background characteristics and their engagement with mCare. Materials and Methods: This analysis included participants who received mCare (n = 95) in a randomized controlled trial. mCare participants received status questionnaires daily for up to 36 weeks. Participant engagement encompasses exposure to mCare, percentage of questionnaires responded to, and response time. Participants were grouped by health status-that is, presence/absence of behavioral health problems, PTS, and/or TBI. Histograms and regression analyses examined engagement by participants' health status and background characteristics. Results: Exposure to mCare did not differ by health status. Participants usually responded to >= 60% of the questionnaires weekly, generally in <= 10 h; however, participants with behavioral health problems had several weeks with <50% response and the longest response times. Total questionnaires responded to and response time did not differ statistically by health status. Older age and higher General Well-Being Schedule scores were associated with greater and faster response. Discussion: The sustained response to the questionnaires suggests engagement. Overall level of response surpassed trends reported for American's usage of mobile applications. With a few exceptions, Service Members engaged with mCare irrespective of health status. Conclusion: Mobile health has the potential to increase the quantity and quality of patient-provider communications in a community-based, rehabilitation care setting, above that of standard care. C1 [Pavliscsak, Holly] USAMRMC, TATRC, Mobile Hlth Care Innovat Ctr MHIC, Geneva Fdn, Ft Gordon, GA 30905 USA. [Little, Jeanette R.] US Army, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Mobile Hlth Innovat Ctr, Ft Gordon, GA 30905 USA. [Poropatich, Ronald K.] Univ Pittsburgh, Ctr Mil Med Res, Pittsburgh, PA USA. [McVeigh, Francis L.] US Army, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Adv Technol & Innovat Lab, Ft Detrick, MD USA. [Tong, James] Govt Solut, IMS Hlth, Washington, DC USA. [Tillman, Johnie S.] Integrated Disabil Evaluat Syst, Ft Gordon, GA USA. [Smith, Challis H.] Virginia Dept Behav Hlth & Dev Serv, Qual Management & Dev, Richmond, VA USA. [Fonda, Stephanie Jo] Walter Reed Natl Mil Med Ctr, Geneva Res Fdn, Dept Endocrinol, Bethesda, MD USA. RP Pavliscsak, H (reprint author), USAMRMC, TATRC, Mobile Hlth Care Innovat Ctr MHIC, Geneva Fdn, Ft Gordon, GA 30905 USA. EM holly.h.pavliscsak.ctr@mail.mil; jeanette.r.little.civ@mail.mil; rkp19@pitt.edu; francis.l.mcveigh.civ@mail.mil; jtong@us.imshealth.com; johnie.s.tillman.civ@mail.mil; chc.smith@us.army.mil; sfonda@genevausa.org RI Emchi, Karma/Q-1952-2016 FU Office of Force Health Protection FX This study was funded by the Office of Force Health Protection, and managed by the Mobile Health Innovation Center, an intramural laboratory of the Telemedicine and Advanced Technology Research Center, United States Army Medical Research and Material Command. NR 29 TC 2 Z9 2 U1 1 U2 2 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1067-5027 EI 1527-974X J9 J AM MED INFORM ASSN JI J. Am. Med. Inf. Assoc. PD JAN PY 2016 VL 23 IS 1 BP 110 EP 118 DI 10.1093/jamia/ocv121 PG 9 WC Computer Science, Information Systems; Computer Science, Interdisciplinary Applications; Health Care Sciences & Services; Information Science & Library Science; Medical Informatics SC Computer Science; Health Care Sciences & Services; Information Science & Library Science; Medical Informatics GA DJ4MK UT WOS:000374179500015 PM 26363048 ER PT J AU Champagne, VK West, MK Rokni, MR Curtis, T Champagne, V McNally, B AF Champagne, Victor Kenneth, III West, Michael K. Rokni, M. Reza Curtis, Todd Champagne, Victor, Jr. McNally, Baillie TI Joining of Cast ZE41A Mg to Wrought 6061 Al by the Cold Spray Process and Friction Stir Welding SO JOURNAL OF THERMAL SPRAY TECHNOLOGY LA English DT Article; Proceedings Paper CT International Thermal Spray Conference CY MAY 11-14, 2015 CL Long Beach, CA SP ASM Int Thermal Spray Soc, German Welding Soc, Int Inst Welding DE cold spray; electron microscopy; mechanical properties; microhardness; microstructure; optical microscopy; tensile bond strength ID ALUMINUM-ALLOY; MAGNESIUM ALLOYS; MICROSTRUCTURE; PARTICLES; INTERFACE; COATINGS AB This paper presents a novel method for joining cast ZE41A-T5 Mg to wrought 6061-T6 Al, without forming deleterious, coarse intermetallic compounds, which is not currently possible with conventional technologies. The novel aspect of the process includes the development of a joint design using cold spray (CS) as the enabling technology, to produce a transitional layer onto which a conventional welding technique can be employed to join the two dissimilar materials. The emphasis in this study will be on the CS transitional layer (T-layer) which enables the joining of cast ZE41A-T5 magnesium (Mg) and wrought 6061-T6 aluminum (Al) by friction-stir welding and the subsequent materials characterization to show the structural integrity of the entire joint. In order to join Mg and Al plates by this method, a transitional layer of CS Al is first deposited along the edge of cast ZE41A Mg plate. The CS Al T-layer enables the Mg to be friction stir welded to a plate of wrought 6061 Al, thereby completing the Mg plate to Al plate joint. Friction stir welding was chosen in this study to join the CS Al T-layer to the wrought Al plate; however, other conventional welding techniques could also be employed for joining Mg to Al in this manner. The CS Al T-layer is compatible to the wrought 6061 Al plate and serves as an insulating layer that prevents heat generated during the friction stir welding process from extending into the magnesium, thus preventing the formation of intermetallics. In this study, two sets of samples were produced joining cast ZE41A-T5 magnesium (Mg) and wrought 6061-T6 aluminum: one set using CS 6061 Al as the transition material between the ZE41A Mg plate and 6061 Al plate and the other set using CS 5056 Al as the transition material. Microstructural analysis by scanning and transmission electron microscopy and optical microscopy, along with mechanical test results including triple lug shear, tension, and micro hardness will be presented. Comparisons will be made to conventional joining techniques and the importance, as well as the applications of this technique, will be discussed. C1 [Champagne, Victor Kenneth, III] Univ Massachusetts, Amherst, MA 01003 USA. [West, Michael K.; Rokni, M. Reza; Curtis, Todd] South Dakota Sch Mines & Technol, Rapid City, SD USA. [Champagne, Victor, Jr.] US Army Res Lab, Aberdeen, MD USA. [McNally, Baillie] Worcester Polytech Inst, Worcester, MA 01609 USA. RP Champagne, V (reprint author), US Army Res Lab, Aberdeen, MD USA. EM vchampagne@umass.edu NR 42 TC 1 Z9 1 U1 9 U2 18 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9630 EI 1544-1016 J9 J THERM SPRAY TECHN JI J. Therm. Spray Technol. PD JAN PY 2016 VL 25 IS 1-2 BP 143 EP 159 DI 10.1007/s11666-015-0301-8 PG 17 WC Materials Science, Coatings & Films SC Materials Science GA DJ5RP UT WOS:000374268000016 ER PT J AU Widener, CA Carter, MJ Ozdemir, OC Hrabe, RH Hoiland, B Stamey, TE Champagne, VK Eden, TJ AF Widener, C. A. Carter, M. J. Ozdemir, O. C. Hrabe, R. H. Hoiland, B. Stamey, T. E. Champagne, V. K. Eden, T. J. TI Application of High-Pressure Cold Spray for an Internal Bore Repair of a Navy Valve Actuator SO JOURNAL OF THERMAL SPRAY TECHNOLOGY LA English DT Article; Proceedings Paper CT International Thermal Spray Conference CY MAY 11-14, 2015 CL Long Beach, CA SP ASM Int Thermal Spray Soc, German Welding Soc, Int Inst Welding DE cold spray; corrosion; marine components; repair; tensile bond strength ID DEPOSITION AB Cold spray is a reduced temperature, supersonic thermal spray process that is increasingly being used to perform repairs on high-value components. In this case, a valve actuator internal bore sealing surface was repaired on an aluminum 6061 hydraulic valve body using high-pressure cold spray. Corrosion damage to non-critical surfaces was also repaired, allowing the part to be returned to service. A high-pressure cold spray system was used to deposit gas-atomized 6061 aluminum powder using helium. The internal bore surfaces were approximately 100 mm in diameter with a depth of nearly 200 mm, and were sprayed using a 45 degrees nozzle 65 mm in length. Modeling predictions validated the approach, and were used to identify a favorable nozzle geometry and process window combination. The minimum required adhesion strength on critical surfaces was 69 MPa. The average adhesion strength was 71.4 MPa, with glue failures on ASTM C633 bond test specimens. The actuator subsequently passed all bench top service related testing, was qualified as an approved repair, and is now in service. This was a first of its kind repair for cold spray, and demonstrates that it is a viable repair technology and is ready for broader implementation. C1 [Widener, C. A.; Carter, M. J.; Ozdemir, O. C.] South Dakota Sch Mines & Technol, Rapid City, SD 57701 USA. [Hrabe, R. H.] VRC Met Syst, Rapid City, SD USA. [Hoiland, B.] MOOG Mid Amer Aviat, West Fargo, ND USA. [Stamey, T. E.] Puget Sound Naval Shipyard, Bremerton, WA USA. [Champagne, V. K.] Army Res Lab, Aberdeen Proving Ground, MD USA. [Eden, T. J.] Penn State Appl Res Lab, State Coll, PA USA. RP Widener, CA (reprint author), South Dakota Sch Mines & Technol, Rapid City, SD 57701 USA. EM Christian.Widener@sdsmt.edu NR 14 TC 2 Z9 2 U1 2 U2 8 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9630 EI 1544-1016 J9 J THERM SPRAY TECHN JI J. Therm. Spray Technol. PD JAN PY 2016 VL 25 IS 1-2 BP 193 EP 201 DI 10.1007/s11666-015-0366-4 PG 9 WC Materials Science, Coatings & Films SC Materials Science GA DJ5RP UT WOS:000374268000020 ER PT J AU Abid, I Bohloul, A Najmaei, S Avendano, C Liu, HL Pechou, R Mlayah, A Lou, J AF Abid, I. Bohloul, A. Najmaei, S. Avendano, C. Liu, H. -L. Pechou, R. Mlayah, A. Lou, J. TI Resonant surface plasmon-exciton interaction in hybrid MoSe2@Au nanostructures SO NANOSCALE LA English DT Article ID TRANSITION-METAL DICHALCOGENIDES; DISCRETE-DIPOLE APPROXIMATION; DISULFIDE ATOMIC LAYERS; MONOLAYER MOS2; ELECTRONIC-STRUCTURE; VALLEY POLARIZATION; QUANTUM-DOT; PHOTOLUMINESCENCE; SEMICONDUCTORS; NANOANTENNA AB In this work we investigate the interaction between plasmonic and excitonic resonances in hybrid MoSe2@Au nanostructures. The latter were fabricated by combining chemical vapor deposition of MoSe2 atomic layers, Au disk processing by nanosphere lithography and a soft lift-off/transfer technique. The samples were characterized by scanning electron and atomic force microscopy. Their optical properties were investigated experimentally using optical absorption, Raman scattering and photoluminescence spectroscopy. The work is focused on a resonant situation where the surface plasmon resonance is tuned to the excitonic transition. In that case, the near-field interaction between the surface plasmons and the confined excitons leads to interference between the plasmonic and excitonic resonances that manifests in the optical spectra as a transparency dip. The plasmonic-excitonic interaction regime is determined using quantitative analysis of the optical extinction spectra based on an analytical model supported by numerical simulations. We found that the plasmonic-excitonic resonances do interfere thus leading to a typical Fano lineshape of the optical extinction. The near-field nature of the plasmonic-excitonic interaction is pointed out experimentally from the dependence of the optical absorption on the number of monolayer stacks on the Au nanodisks. The results presented in this work contribute to the development of new concepts in the field of hybrid plasmonics. C1 [Abid, I.; Pechou, R.; Mlayah, A.] Univ Toulouse, CNRS, UPR 8011, Ctr Elaborat Mat & Etud Struct, 29 Rue Jeanne Marvig,BP 94347, F-31055 Toulouse, France. [Bohloul, A.; Najmaei, S.; Avendano, C.; Lou, J.] Rice Univ, Dept Mat Sci & NanoEngn, Houston, TX 77005 USA. [Najmaei, S.] Sensors & Electron Devices Directorate, US Army Res Labs, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Liu, H. -L.] Natl Taiwan Normal Univ, Dept Phys, Taipei 11677, Taiwan. RP Mlayah, A (reprint author), Univ Toulouse, CNRS, UPR 8011, Ctr Elaborat Mat & Etud Struct, 29 Rue Jeanne Marvig,BP 94347, F-31055 Toulouse, France.; Lou, J (reprint author), Rice Univ, Dept Mat Sci & NanoEngn, Houston, TX 77005 USA. EM adnen.mlayah@cemes.fr; jlou@rice.edu FU HPC center CALMIP at the Paul Sabatier University of Toulouse; Labex-NEXT "PLEXMOS" grant; LabEx NEXT under the "incoming PhD" mobility program; Welch Foundation [C-1716]; NSF [ECCS-1327093]; AFOSR [FA9550-14-1-0268]; Ministry of Science and Technology of Republic of China [NSC 102-2112-M-003-002-MY3] FX This work was supported by the HPC center CALMIP at the Paul Sabatier University of Toulouse and by the Labex-NEXT "PLEXMOS" grant. Also S. N. thanks LabEx NEXT for financial support under the "incoming PhD" mobility program. S. N. and J. L. also thank the support of the Welch Foundation grant C-1716, the NSF grant ECCS-1327093 and the AFOSR grant FA9550-14-1-0268. H. L. L. thanks financial support from the Ministry of Science and Technology of Republic of China under grant no. NSC 102-2112-M-003-002-MY3. NR 51 TC 4 Z9 4 U1 32 U2 64 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2040-3364 EI 2040-3372 J9 NANOSCALE JI Nanoscale PY 2016 VL 8 IS 15 BP 8151 EP 8159 DI 10.1039/c6nr00829a PG 9 WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA DJ4FA UT WOS:000374159600042 PM 27029770 ER PT J AU Wahl-Jensen, V Johnson, JC Lauck, M Weinfurter, JT Moncla, LH Weiler, AM Charlier, O Rojas, O Byrum, R Ragland, DR Huzella, L Zommer, E Cohen, M Bernbaum, JG Cai, YY Sanford, HB Mazur, S Johnson, RF Qin, J Palacios, GF Bailey, AL Jahrling, PB Goldberg, TL O'Connor, DH Friedrich, TC Kuhn, JH AF Wahl-Jensen, Victoria Johnson, Joshua C. Lauck, Michael Weinfurter, Jason T. Moncla, Louise H. Weiler, Andrea M. Charlier, Olivia Rojas, Oscar Byrum, Russell Ragland, Dan R. Huzella, Louis Zommer, Erika Cohen, Melanie Bernbaum, John G. Cai, Yingyun Sanford, Hannah B. Mazur, Steven Johnson, Reed F. Qin, Jing Palacios, Gustavo F. Bailey, Adam L. Jahrling, Peter B. Goldberg, Tony L. O'Connor, David H. Friedrich, Thomas C. Kuhn, Jens H. TI Divergent Simian Arteriviruses Cause Simian Hemorrhagic Fever of Differing Severities in Macaques SO MBIO LA English DT Article ID ENDOPLASMIC-RETICULUM; HAEMORRHAGIC FEVER; VIRUS; PATHOLOGY; OUTBREAK; DISEASE; AGENT AB Simian hemorrhagic fever (SHF) is a highly lethal disease in captive macaques. Three distinct arteriviruses are known etiological agents of past SHF epizootics, but only one, simian hemorrhagic fever virus (SHFV), has been isolated in cell culture. The natural reservoir(s) of the three viruses have yet to be identified, but African nonhuman primates are suspected. Eleven additional divergent simian arteriviruses have been detected recently in diverse and apparently healthy African cercopithecid monkeys. Here, we report the successful isolation in MARC-145 cell culture of one of these viruses, Kibale red colobus virus 1 (KRCV-1), from serum of a naturally infected red colobus (Procolobus [Piliocolobus] rufomitratus tephrosceles) sampled in Kibale National Park, Uganda. Intramuscular (i.m.) injection of KRCV-1 into four cynomolgus macaques (Macaca fascicularis) resulted in a self-limiting nonlethal disease characterized by depressive behavioral changes, disturbance in coagulation parameters, and liver enzyme elevations. In contrast, i.m. injection of SHFV resulted in typical lethal SHF characterized by mild fever, lethargy, lymphoid depletion, lymphoid and hepatocellular necrosis, low platelet counts, increased liver enzyme concentrations, coagulation abnormalities, and increasing viral loads. As hypothesized based on the genetic and presumed antigenic distance between KRCV-1 and SHFV, all four macaques that had survived KRCV-1 injection died of SHF after subsequent SHFV injection, indicating a lack of protective heterotypic immunity. Our data indicate that SHF is a disease of macaques that in all likelihood can be caused by a number of distinct simian arteriviruses, although with different severity depending on the specific arterivirus involved. Consequently, we recommend that current screening procedures for SHFV in primate-holding facilities be modified to detect all known simian arteriviruses. IMPORTANCE Outbreaks of simian hemorrhagic fever (SHF) have devastated captive Asian macaque colonies in the past. SHF is caused by at least three viruses of the family Arteriviridae: simian hemorrhagic fever virus (SHFV), simian hemorrhagic encephalitis virus (SHEV), and Pebjah virus (PBJV). Nine additional distant relatives of these three viruses were recently discovered in apparently healthy African nonhuman primates. We hypothesized that all simian arteriviruses are potential causes of SHF. To test this hypothesis, we inoculated cynomolgus macaques with a highly divergent simian arterivirus (Kibale red colobus virus 1 [KRCV-1]) from a wild Ugandan red colobus. Despite being only distantly related to red colobuses, all of the macaques developed disease. In contrast to SHFV-infected animals, KRCV-1-infected animals survived after a mild disease presentation. Our study advances the understanding of an important primate disease. Furthermore, our data indicate a need to include the full diversity of simian arteriviruses in nonhuman primate SHF screening assays. C1 [Wahl-Jensen, Victoria; Johnson, Joshua C.; Rojas, Oscar; Byrum, Russell; Ragland, Dan R.; Huzella, Louis; Zommer, Erika; Cohen, Melanie; Bernbaum, John G.; Cai, Yingyun; Sanford, Hannah B.; Mazur, Steven; Jahrling, Peter B.; Kuhn, Jens H.] NIAID, NIH, Integrated Res Facil Ft Detrick, Frederick, MD USA. [Lauck, Michael; Weinfurter, Jason T.; Moncla, Louise H.; Weiler, Andrea M.; Charlier, Olivia; Bailey, Adam L.; Goldberg, Tony L.; O'Connor, David H.; Friedrich, Thomas C.] Univ Wisconsin, Madison, WI USA. [Johnson, Reed F.; Jahrling, Peter B.] NIAID, NIH, Emerging Viral Pathogens Sect, Frederick, MD USA. [Qin, Jing] NIAID, NIH, Biostat Res Branch, Rockville, MD USA. [Palacios, Gustavo F.] US Army, Med Res Inst Infect Dis, Frederick, MD USA. RP Kuhn, JH (reprint author), NIAID, NIH, Integrated Res Facil Ft Detrick, Frederick, MD USA. EM kuhnjens@mail.nih.gov OI Palacios, Gustavo/0000-0001-5062-1938; Friedrich, Thomas/0000-0001-9831-6895 FU Battelle Memorial Institute; US National Institute of Allergy and Infectious Diseases (NIAID) [HHSN272200700016I]; NIAID Division of Intramural Research; Wisconsin National Primate Research Center Base Grant from the National Center for Research Resources [P51 RR000167]; Office of Research Infrastructure Programs of the National Institutes of Health (NIH) [P51 OD011106]; NIH [R01AI116382]; NIH as part of the joint NIH-NSF Ecology of Infectious Disease program [R01 AI077376]; Office of Research Infrastructure Programs (ORIP) [P51OD011106]; National Research Service Award (NRSA) through Microbes in Health and Disease (MHD) training program at the University of Wisconsin [T32 AI55397]; University of Wisconsin's Medical Scientist Training Program (MSTP) [T32 GM008692] FX This work was funded in part through Battelle Memorial Institute's prime contract with the US National Institute of Allergy and Infectious Diseases (NIAID) under Contract No. HHSN272200700016I. J.C.J. performed this work as an employee of Battelle Memorial Institute. Subcontractors to Battelle Memorial Institute who performed this work are: O.R., R.B., D.R.R., L.H., employees of Charles River Laboratories; V.W-J., J.G.B, Y.C., H.B.S., and J.H.K, employees of Tunnell Government Services, Inc.; M.C., an employee of Lovelace Respiratory Research Institute; and E.Z. and S.M., employees of MRIGlobal Research Institute. This study was also funded, in part, by the NIAID Division of Intramural Research (R.F.J., P.B.J.). The work of M.L., J.T.W., L.H.M., A.M.W., O.C., A.L.B., T.L.G., D.H.O'C., and T.C.F. was supported in part by the Wisconsin National Primate Research Center Base Grant from the National Center for Research Resources (P51 RR000167) and the Office of Research Infrastructure Programs (P51 OD011106) of the National Institutes of Health (NIH); NIH grant R01AI116382; NIH grant TW009237 as part of the joint NIH-NSF Ecology of Infectious Disease program, grant R01 AI077376; and by the Office of Research Infrastructure Programs (ORIP) grant P51OD011106. A.L.B. was additionally supported via a National Research Service Award (NRSA) through the Microbes in Health and Disease (MHD) training program at the University of Wisconsin (T32 AI55397) and University of Wisconsin's Medical Scientist Training Program (MSTP) grant T32 GM008692. NR 30 TC 2 Z9 2 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 2150-7511 J9 MBIO JI mBio PD JAN-FEB PY 2016 VL 7 IS 1 AR e02009-15 DI 10.1128/mBio.02009-15 PG 10 WC Microbiology SC Microbiology GA DJ0ZO UT WOS:000373933100065 PM 26908578 ER PT J AU Nafari, RH Ngo, T Lehman, W AF Nafari, R. Hasanzadeh Ngo, T. Lehman, W. TI Calibration and validation of FLFA(rs) - a new flood loss function for Australian residential structures SO NATURAL HAZARDS AND EARTH SYSTEM SCIENCES LA English DT Article ID DAMAGE ESTIMATION; COMMERCIAL SECTOR; BUILDINGS; MODEL; FLEMOCS; CURVES; AREAS AB Rapid urbanisation, climate change and unsustainable developments are increasing the risk of floods. Flood is a frequent natural hazard that has significant financial consequences for Australia. The emergency response system in Australia is very successful and has saved many lives over the years. However, the preparedness for natural disaster impacts in terms of loss reduction and damage mitigation has been less successful. In this paper, a newly derived flood loss function for Australian residential structures (FLFA(rs)) has been presented and calibrated by using historic data collected from an extreme event in Queensland, Australia, that occurred in 2013. Afterwards, the performance of the method developed in this work (contrasted to one Australian model and one model from USA) has been compared with the observed damage data collected from a 2012 flood event in Maranoa, Queensland. Based on this analysis, validation of the selected methodologies has been performed in terms of Australian geographical conditions. Results obtained from the new empirically based function (FLFA(rs)) and the other models indicate that it is apparent that the precision of flood damage models is strongly dependent on selected stage damage curves, and flood damage estimation without model calibration might result in inaccurate predictions of losses. Therefore, it is very important to be aware of the associated uncertainties in flood risk assessment, especially if models have not been calibrated with real damage data. C1 [Nafari, R. Hasanzadeh] Univ Melbourne, Dept Infrastruct Engn, CDMPS, Melbourne, Vic, Australia. [Ngo, T.] Univ Melbourne, Dept Infrastruct Engn, Adv Protect Technol Engn Struct APTES Grp, Melbourne, Vic, Australia. [Lehman, W.] USACE, Inst Water Resources, HEC, Davis, CA USA. RP Nafari, RH (reprint author), Univ Melbourne, Dept Infrastruct Engn, CDMPS, Melbourne, Vic, Australia. EM rhasanzadeh@student.unimelb.edu.au RI Hasanzadeh Nafari, Roozbeh/N-3934-2015 OI Hasanzadeh Nafari, Roozbeh/0000-0002-3987-4974 FU Bushfire and Natural Hazards CRC FX We would like to thank the Queensland Reconstruction Authority for their kind support and for providing us with invaluable resources and data sets. Also, the authors would like to acknowledge the ongoing financial contribution and support from the Bushfire and Natural Hazards CRC. NR 55 TC 2 Z9 2 U1 1 U2 3 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY SN 1561-8633 J9 NAT HAZARD EARTH SYS JI Nat. Hazards Earth Syst. Sci. PY 2016 VL 16 IS 1 BP 15 EP 27 DI 10.5194/nhess-16-15-2016 PG 13 WC Geosciences, Multidisciplinary; Meteorology & Atmospheric Sciences; Water Resources SC Geology; Meteorology & Atmospheric Sciences; Water Resources GA DJ0TC UT WOS:000373916300002 ER PT B AU Bravo, L Xue, QL Som, S Powell, C Kweon, CBM AF Bravo, Luis Xue, Qingluan Som, Sibendu Powell, Christopher Kweon, Chol-Bum M. GP ASME TI FUEL EFFECTS ON NOZZLE FLOW AND SPRAY USING FULLY COUPLED EULERIAN SIMULATIONS SO PROCEEDINGS OF THE ASME POWER CONFERENCE, 2015 LA English DT Proceedings Paper CT ASME 2015 Power Conference, POWER2015 CY JUN 28-JUL 02, 2015 CL San Diego, CA SP ASME, Power Div ID X-RAY RADIOGRAPHY; SURROGATE MIXTURES; COMBUSTION; MODEL; JP-8; COMPONENTS AB The objective of this study is to examine the impact of single and multi-component surrogate fuel mixtures on the atomization and mixing characteristics of non-reacting isothermal diesel engine sprays. An Eulerian modeling approach was adopted to simulate both the internal nozzle flow dynamics and the emerging turbulent spray in the near nozzle region in a fully-coupled manner. The Volume of Fluids (VoF) methodology was utilized to treat the two-phase flow dynamics including a Homogenous Relaxation approach to account for nozzle cavitation effects. To enable accurate simulations, the nozzle geometry and in-situ multi-dimensional needle lift and off-axis motion profiles have been characterized via the X-ray phase-contrast technique at Argonne National Laboratory. The flow turbulence is treated via the classical k - epsilon Reynolds Average Navier Stoke (RANS) model with in-nozzle and near field resolution of 30 mu m. Several multi-component surrogate mixtures were implemented using linear blending rules to examine the behavior of petroleum, and alternative fuels including: JP -8, JP-5, Hydro-treated Renewable Jet (HRJ), Iso-Paraffinic Kerosene (IPK) with comparison to single component n-dodecane fuel on ECN Spray A nozzle spray dynamics. The results were validated using transient rate-of injection measurements from the Army Research Laboratory at Spray A conditions as well as projected density fields obtained from the line-of-sight measurements from X-ray radiography measurements at The Advanced Photon Source at Argonne National Laboratory. The conditions correspond to injection pressure, nominal fuel temperature, and ambient density of 1500 bar, 363 K, and 22.8 kg/m(3), respectively. The simulation results provide a unique high-fidelity contribution to the effects of fuels on the spray mixing dynamics. The results can lead to improvements in fuel mixture distributions enhancing performance of military vehicles. C1 [Bravo, Luis; Kweon, Chol-Bum M.] US Army Res Lab, Aberdeen Proving Ground, MD USA. [Xue, Qingluan; Som, Sibendu; Powell, Christopher] Argonne Natl Lab, 9700 S Cass Ave, Argonne, IL 60439 USA. RP Bravo, L (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD USA. NR 21 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-5660-4 PY 2016 AR V001T03A012 PG 11 WC Energy & Fuels; Engineering, Mechanical SC Energy & Fuels; Engineering GA BE6DW UT WOS:000373970600032 ER PT B AU Wierzbicki, TA Lee, IC Gupta, AK AF Wierzbicki, Teresa A. Lee, Ivan C. Gupta, Ashwani K. GP ASME TI CATALYTIC OXIDATION OF JET FUEL SURROGATES IN A MESO-SCALE COMBUSTOR SO PROCEEDINGS OF THE ASME POWER CONFERENCE, 2015 LA English DT Proceedings Paper CT ASME 2015 Power Conference, POWER2015 CY JUN 28-JUL 02, 2015 CL San Diego, CA SP ASME, Power Div DE Catalytic combustion; JP-8 surrogate; meso-scale combustion; reaction kinetics; hybrid combustion ID HEAT-RECIRCULATING COMBUSTORS; GAS SHIFT REACTION; LOW-TEMPERATURE; HIGHER HYDROCARBONS; METAL-CATALYSTS; PERFORMANCE; HEXADECANE; SYSTEM; DECANE; CELLS AB Oxidation behavior of dodecane and two mixtures of dodecane and m-xylene (90/10 wt. % and 80/20 wt. %) over an Rh catalyst in a meso-scale heat recirculating combustor was examined to isolate the effect of aromatic content on performance. The fuel conversion, product speciation and reaction kinetics were calculated, and the global combustion behavior observed. The results showed that increasing the amount of m-xylene in the fuel increased the fuel conversion from 85% (pure dodecane) to 92% (90/10) and further to 98% (80/20). The presence of xylene also significantly increased CO2/H2O selectivity and de-creased CO/H-2 selectivity. Global activation energy increased linearly with increase in xylene content, supporting that addition of aromatic species to fuel lowers the overall reactivity. The non-catalytic reaction was also simulated using Chemkin software to determine the effect of the Rh catalyst on the combustor performance. The results revealed that the catalyst promotes total oxidation over partial oxidation, and lowers the global activation energy by up to 70%. C1 [Wierzbicki, Teresa A.; Gupta, Ashwani K.] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. [Lee, Ivan C.] US Army Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD USA. RP Wierzbicki, TA (reprint author), Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. NR 41 TC 0 Z9 0 U1 2 U2 2 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-5660-4 PY 2016 AR V001T03A006 PG 9 WC Energy & Fuels; Engineering, Mechanical SC Energy & Fuels; Engineering GA BE6DW UT WOS:000373970600026 ER PT J AU Krakauer, T AF Krakauer, Teresa TI Enterotoxins: Microbial Proteins and Host Cell Dysregulation SO TOXINS LA English DT Editorial Material DE staphylococcal superantigens; clostridial toxins; receptor binding; toxicity; inflammation; therapeutics ID PERFRINGENS BETA-TOXIN; CLOSTRIDIUM; TOXICITY; BINDING; SUPERANTIGENS; DOMAIN C1 [Krakauer, Teresa] US Army, Med Res Inst Infect Dis, Dept Immunol, Mol Translat Sci Div, Ft Detrick, MD 21702 USA. RP Krakauer, T (reprint author), US Army, Med Res Inst Infect Dis, Dept Immunol, Mol Translat Sci Div, Ft Detrick, MD 21702 USA. EM Teresa.krakauer.civ@mail.mil NR 16 TC 0 Z9 0 U1 1 U2 1 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2072-6651 J9 TOXINS JI Toxins PD JAN PY 2016 VL 8 IS 1 AR 17 DI 10.3390/toxins8010017 PG 4 WC Toxicology SC Toxicology GA DJ6OL UT WOS:000374332700017 ER PT J AU Hohenforst-Schmidt, W Zarogoulidis, P Pitsiou, G Linsmeier, B Tsavlis, D Kioumis, I Papadaki, E Freitag, L Tsiouda, T Turner, JF Browning, R Simoff, M Sachpekidis, N Tsakiridis, K Zaric, B Yarmus, L Baka, S Stratakos, G Rittger, H AF Hohenforst-Schmidt, Wolfgang Zarogoulidis, Paul Pitsiou, Georgia Linsmeier, Bernd Tsavlis, Drosos Kioumis, Ioannis Papadaki, Eleni Freitag, Lutz Tsiouda, Theodora Turner, J. Francis Browning, Robert Simoff, Michael Sachpekidis, Nikolaos Tsakiridis, Kosmas Zaric, Bojan Yarmus, Lonny Baka, Sofia Stratakos, Grigoris Rittger, Harald TI Drug Eluting Stents for Malignant Airway Obstruction: A Critical Review of the Literature SO JOURNAL OF CANCER LA English DT Review DE pharmacology; stents ID CELL LUNG-CANCER; PERCUTANEOUS CORONARY INTERVENTION; EVEROLIMUS PLUS EXEMESTANE; BARE-METAL STENTS; BODY-SURFACE AREA; OPTICAL COHERENCE TOMOGRAPHY; FLUOROURACIL DOSE ADJUSTMENT; METASTATIC COLORECTAL-CANCER; NON-INFERIORITY TRIAL; LONG-TERM OUTCOMES AB Lung cancer being the most prevalent malignancy in men and the 3rd most frequent in women is still associated with dismal prognosis due to advanced disease at the time of diagnosis. Novel targeted therapies are already on the market and several others are under investigation. However non-specific cytotoxic agents still remain the cornerstone of treatment for many patients. Central airways stenosis or obstruction may often complicate and decrease quality of life and survival of these patients. Interventional pulmonology modalities (mainly debulking and stent placement) can alleviate symptoms related to airways stenosis and improve the quality of life of patients. Mitomycin C and sirolimus have been observed to assist a successful stent placement by reducing granuloma tissue formation. Additionally, these drugs enhance the normal tissue ability against cancer cell infiltration. In this mini review we will concentrate on mitomycin C and sirolimus and their use in stent placement. C1 [Hohenforst-Schmidt, Wolfgang; Rittger, Harald] Univ Erlangen Nurnberg, Fuerth Hosp, Med Clin 1, Furth, Germany. [Zarogoulidis, Paul; Pitsiou, Georgia; Tsavlis, Drosos; Kioumis, Ioannis; Papadaki, Eleni; Tsiouda, Theodora] Aristotle Univ Thessaloniki, G Papanikolaou Gen Hosp, Dept Pulm, Oncol Unit, GR-54006 Thessaloniki, Greece. [Linsmeier, Bernd] Coburg Clin, Dept Gen Surg, Coburg, Germany. [Freitag, Lutz] Univ Essen Duisburg, Univ Hosp Essen, Ruhrlandklin, Dept Intervent Pneumol, Tueschener Weg 40, D-45239 Essen, Germany. [Turner, J. Francis] Western Reg Med Ctr, Canc Treatment Ctr Amer, Div Intervent Pulmonol & Med Oncol, Goodyear, AZ USA. [Browning, Robert] Walter Reed Army Med Ctr, Natl Naval Med Ctr, Pulm & Crit Care Med, Intervent Pulmonol, Bethesda, MD USA. [Simoff, Michael] Wayne State Univ, Henry Ford Hosp, Sch Med, Bronchoscopy & Intervent Pulmonol,Pulm & Crit Car, Detroit, MI 48202 USA. [Sachpekidis, Nikolaos; Tsakiridis, Kosmas] St Luke Private Hosp, Dept Cardiothorac Surg, Thessaloniki, Panorama, Greece. [Zaric, Bojan] Univ Novi Sad, Fac Med, Clin Thorac Oncol, Inst Pulm Dis Vojvodina, Novi Sad 21000, Serbia. [Yarmus, Lonny] Sheikh Zayed Cardiovasc & Crit Care Tower, Div Pulm & Crit Care Med, Baltimore, MD USA. [Baka, Sofia] Interbalkan European Med Ctr, Dept Oncol, Thessaloniki, Greece. [Stratakos, Grigoris] Natl Univ Athens, Sotiria Gen Hosp Athens, Resp Med Dept 1, Athens, Greece. RP Zarogoulidis, P (reprint author), Aristotle Univ Thessaloniki, G Papanikolaou Gen Hosp, Dept Pulm, Oncol Unit, GR-54006 Thessaloniki, Greece. EM pzarog@hotmail.com NR 149 TC 5 Z9 5 U1 5 U2 8 PU IVYSPRING INT PUBL PI LAKE HAVEN PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA SN 1837-9664 J9 J CANCER JI J. Cancer PY 2016 VL 7 IS 4 BP 377 EP 390 DI 10.7150/jca.13611 PG 14 WC Oncology SC Oncology GA DI3YX UT WOS:000373438000004 PM 26918052 ER PT J AU Doyle, JD Howard, IL AF Doyle, Jesse D. Howard, Isaac L. TI Characterization of Dense-Graded Asphalt With the Cantabro Test SO JOURNAL OF TESTING AND EVALUATION LA English DT Article DE asphalt mixture; flexible pavements; reclaimed asphalt pavement; warm mix asphalt ID FRICTION COURSE MIXTURES; MIX DESIGN; PERFORMANCE AB Durability of dense-graded asphalt (DGA) is a key issue with regards to long term pavement performance. There is a need for a practical and implementable test to estimate these parameters. Previous research has suggested that the Cantabro abrasion loss test has potential for this application. Both the development of the Cantabro method and its conventional application to open-graded friction course (OGFC) mixtures are reviewed. A four component research approach was undertaken to evaluate suitability of the Cantabro test for DGA mixtures that included testing of 438 specimens from 69 different mixtures. First, sensitivity of the test was assessed using a large range of typical Mississippi DGA mixtures. Second, variability of the test was measured by evaluating data sets with thirty replicates. Third, the effects of oven conditioning protocols were measured. Fourth, the effects of varying reclaimed asphalt pavement (RAP) contents were measured for warm-mix asphalt (WMA). The overall recommendation from the research was that the Cantabro test be given serious consideration for use as a durability measurement tool for DGA mixtures. C1 [Doyle, Jesse D.] US Army Corps Engn, Engineer Res & Dev Ctr, CEERD GM A, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. [Howard, Isaac L.] Mississippi State Univ, Dept Civil & Environm Engn, Mat & Construct Ind Chair, 501 Hardy Rd,POB 9546, Mississippi State, MS 39762 USA. RP Howard, IL (reprint author), Mississippi State Univ, Dept Civil & Environm Engn, Mat & Construct Ind Chair, 501 Hardy Rd,POB 9546, Mississippi State, MS 39762 USA. EM ilhoward@cee.msstate.edu FU MDOT [212] FX This research was largely funded by MDOT under State Study 212 and principal investigator Isaac L. Howard. Permission to publish was granted by the Director, Geotechnical and Structures Laboratory, U.S. Army Engineer Research and Development Center. NR 33 TC 0 Z9 0 U1 4 U2 6 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 USA SN 0090-3973 EI 1945-7553 J9 J TEST EVAL JI J. Test. Eval. PD JAN PY 2016 VL 44 IS 1 BP 77 EP 88 DI 10.1520/JTE20140212 PG 12 WC Materials Science, Characterization & Testing SC Materials Science GA DJ0RG UT WOS:000373911500008 ER PT J AU Toblin, RL Anderson, JA Riviere, LA McGurk, D Sipos, ML AF Toblin, Robin L. Anderson, James A. Riviere, Lyndon A. McGurk, Dennis Sipos, Maurice L. TI The Impact of Unit Membership on Smoking Among Soldiers SO MILITARY MEDICINE LA English DT Article ID TOBACCO USE; US MILITARY; QUALITATIVE-ANALYSIS; CIGARETTE-SMOKING; STATES-ARMY; ASSOCIATION; PREVALENCE; PERSONNEL; PEER AB Cultural, organizational, and dyadic influences have been found to be associated with smoking in the military while group-level influences have been identified in the general population. However, there are few studies examining group-level influences in the military and none using group-level analyses. Such studies are essential for understanding how to optimally forestall or cease smoking. This study, using mixed effects modelling, examined whether unit membership influenced smoking behavior in soldiers from brigade combat teams. Unit membership was assessed in 2008 to 2009 at the company level (n = 2204) and in 2012 at the platoon level (n = 452). Smoking was assessed by the number of daily cigarettes smoked (range: 0-99) with smoking status (nonsmoker vs. smoker) and smoking level (none, smoker, and heavy [20 + cigarettes/day]) as the outcomes. For both samples, unit membership was not significantly associated with a soldier's propensity to smoke when comparing either all smokers to nonsmokers or heavy smokers to smokers. These results suggest typical military unit-level training programs are unlikely to be the most effective mode of intervention for smoking prevention or cessation. Smoking rates in the military may be influenced instead by small group or individual relationships or by overall military culture. C1 [Toblin, Robin L.; Anderson, James A.; Riviere, Lyndon A.; Sipos, Maurice L.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. [Toblin, Robin L.] US PHS, Commissioned Corps, 1101 Wootton Pkwy,Plaza Level, Rockville, MD 20852 USA. [McGurk, Dennis] US Army Med Res & Mat Command, Mil Operat Med Res Program, 504 Scott St, Ft Detrick, MD 21702 USA. RP Toblin, RL (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. FU U.S. Army Medical Research and Materiel Command (USAMRMC) FX We would like to thank COL (Ret.) Paul Bliese, PhD of the University of South Carolina for his statistical advice, the Joint Mental Health Advisory Team-8 that collected data in Afghanistan in 2012 (Team Commander: LTC Dennis McGurk, a co-author), and the soldiers and units that participated in data collection. This work was supported by the U.S. Army Medical Research and Materiel Command (USAMRMC) for intramural funding that supports enhancing the psychological resilience of the warfighter. USAMRMC did not have any specific role in this manuscript. NR 35 TC 1 Z9 1 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JAN PY 2016 VL 181 IS 1 BP 16 EP 20 DI 10.7205/MILMED-D-15-00063 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA DI3MZ UT WOS:000373404100007 PM 26741472 ER PT J AU Barnes, VA Monto, A Williams, JJ Rigg, JL AF Barnes, Vernon A. Monto, Andrea Williams, Jennifer J. Rigg, John L. TI Impact of Transcendental Meditation on Psychotropic Medication Use Among Active Duty Military Service Members With Anxiety and PTSD SO MILITARY MEDICINE LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; BLOOD-PRESSURE; VETERANS; REDUCTION; EFFICACY; TRIAL AB The purpose of the study was to determine whether the regular practice of Transcendental Meditation (TM) decreased the need for psychotropic medications required for anxiety and post-traumatic stress disorder (PTSD) management and increased psychological wellbeing. The sample included 74 military Service Members with documented PTSD or anxiety disorder not otherwise specified (ADNOS), 37 that practiced TM and 37 that did not. At 1 month, 83.7% of the TM group stabilized, decreased, or ceased medications and 10.8% increased medication dosage; compared with 59.4% of controls that showed stabilizations, decreases, or cessations; and 40.5% that increased medications (p < 0.03). A similar pattern was observed after 2 (p < 0.27), 3 (p < 0.002), and 6 months (p < 0.34). Notably, there was a 20.5% difference between groups in severity of psychological symptoms after 6 months, that is, the control group experienced an increase in symptom severity compared with the group practicing TM. These findings provide insight into the benefits of TM as a viable treatment modality in military treatment facilities for reducing PTSD and ADNOS psychological symptoms and associated medication use. C1 [Barnes, Vernon A.] Georgia Regents Univ, Georgia Prevent Inst, HS1640, Augusta, GA 30912 USA. [Monto, Andrea] Pearl Kruse Way, 4550 Carman Dr, Lake Oswego, OR 97035 USA. [Williams, Jennifer J.; Rigg, John L.] Dwight D Eisenhower Army Med Ctr, Neurosci & Rehabil Ctr, Traumat Brain Injury Clin, Ft Gordon, GA 30905 USA. RP Barnes, VA (reprint author), Georgia Regents Univ, Georgia Prevent Inst, HS1640, Augusta, GA 30912 USA. FU David Lynch Foundation Operation Warrior Wellness FX Funding for Transcendental Meditation training was provided by the David Lynch Foundation Operation Warrior Wellness. NR 30 TC 0 Z9 0 U1 8 U2 12 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JAN PY 2016 VL 181 IS 1 BP 56 EP 63 DI 10.7205/MILMED-D-14-00333 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA DI3MZ UT WOS:000373404100012 PM 26741477 ER PT J AU Mallory, R Jackson, JL Mondragon, D Hatzigeorgiou, C DeZee, KJ Greenburg, D O'Malley, PG AF Mallory, Renee Jackson, Jeffrey L. Mondragon, Donald Hatzigeorgiou, Christos DeZee, Kent J. Greenburg, David O'Malley, Patrick G. TI Characteristics of Highly Rated Internal Medicine Attendings Before and After the 2004 Work-Hour Restrictions SO MILITARY MEDICINE LA English DT Article ID RESIDENT DUTY-HOURS; NEW-YORK-STATE; AMBULATORY-CARE; CLINICAL TEACHERS; FACULTY; ROUNDS; IMPACT; PERCEPTIONS; REGULATIONS; SUPERVISION AB Objectives: To describe the characteristics of top-rated Internal Medicine attendings and whether they changed after implementation of the 2004 work-hour restrictions. Methods: Mixed methods study of resident ratings of medicine attendings (Period 1: 1994-1996, n = 250 and Period 2: 2007-2009, n = 152). Residents evaluated 17 attending characteristics. The top 25% of "overall" ratings were classified as "highly rated." Two free-text questions included "What was your attending's best characteristic?" and "How could your attending best improve?" and were coded in duplicate, using grounded qualitative methods. Results: There were no differences in the characteristics of highly rated attendings in the two time periods. Characteristics associated with being a top-rated attending included enthusiasm (odds ratio [OR]: 5.69, 2.78-11.67), balanced teaching style (OR: 3.63, 1.64-8.02), promoting independent thinking (OR: 2.90, 0.96-8.74), fund of knowledge (OR: 2.73, 1.13-6.58), and time management (OR: 1.78, 1.14-2.80). Among the 1,410 utterances, valued attending attributes included helpfulness, promoting independent thinking, and having strong medical knowledge. Conclusions: The characteristics valued by residents in attendings did not change over time despite a major structural change in work hours and patterns of teaching. These valued characteristics continue to be a strong general fund of knowledge, enthusiasm for teaching, and balance between didactic and bedside approaches. C1 [Mallory, Renee] Walter Reed Natl Mil Med Ctr, Dept Med, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. [Jackson, Jeffrey L.] Zablocki VAMC, Dept Med, 5000 W Natl Ave, Milwaukee, WI 53295 USA. [Mondragon, Donald; Hatzigeorgiou, Christos] Dwight D Eisenhower Med Ctr, Dept Med, 300 East Hosp Rd, Ft Gordon, GA 30905 USA. [DeZee, Kent J.] Tripler Army Med Ctr, Grad Med Educ, 1 Jarrett White Rd, Honolulu, HI 96859 USA. [Greenburg, David] Uniformed Serv Univ Hlth Sci, Dept Ophthalmol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. [O'Malley, Patrick G.] Uniformed Serv Univ Hlth Sci, Dept Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. RP Mallory, R (reprint author), Walter Reed Natl Mil Med Ctr, Dept Med, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. NR 39 TC 0 Z9 0 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JAN PY 2016 VL 181 IS 1 BP 76 EP 81 DI 10.7205/MILMED-D-14-00445 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA DI3MZ UT WOS:000373404100015 PM 26741480 ER PT J AU Cutter, L AF Cutter, Laura TI Walter Reed, Yellow Fever, and Informed Consent SO MILITARY MEDICINE LA English DT Editorial Material C1 [Cutter, Laura] US Army Med Res & Mat Command, Natl Museum Hlth & Med, Amer Registry Pathol, 2500 Linden Lane, Silver Spring, MD 20910 USA. RP Cutter, L (reprint author), US Army Med Res & Mat Command, Natl Museum Hlth & Med, Amer Registry Pathol, 2500 Linden Lane, Silver Spring, MD 20910 USA. NR 2 TC 0 Z9 0 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JAN PY 2016 VL 181 IS 1 BP 90 EP 91 DI 10.7205/MILMED-D-15-00430 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA DI3MZ UT WOS:000373404100017 PM 26741482 ER PT J AU House, JM AF House, Jonathan M. TI Marshal K. K. Rokossovsky: The Red Army's Gentleman Commander. SO RUSSIAN REVIEW LA English DT Book Review C1 [House, Jonathan M.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP House, JM (reprint author), US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0036-0341 EI 1467-9434 J9 RUSS REV JI Russ. Rev. PD JAN PY 2016 VL 75 IS 1 BP 164 EP 166 PG 3 WC History SC History GA DI6LH UT WOS:000373609900030 ER PT J AU Lambert, AE Watson, JM Stefanucci, JK Ward, N Bakdash, JZ Strayer, DL AF Lambert, Ann E. Watson, Jason M. Stefanucci, Jeanine K. Ward, Nathan Bakdash, Jonathan Z. Strayer, David L. TI Stereotype Threat Impairs Older Adult Driving SO APPLIED COGNITIVE PSYCHOLOGY LA English DT Article ID WORKING-MEMORY CAPACITY; DRIVER DISTRACTION; SIMULATOR SICKNESS; PERFORMANCE; MATH; TASK; ATTENTION; PRESSURE; MULTITASKING; PROFILES AB Stereotypes can harm human performance, especially when activated in individuals with diminished working memory capacity (WMC). Performance implications for the stereotype of poor driving in older adults were investigated. Using a sample of older adults, WMC (the ability to maintain task goals and ignore distractions) and driving performance [brake reaction time (RT), following distance, and crashes] were assessed, the latter using a high-fidelity simulator. Elderly participants under stereotype threat with reduced WMC exhibited slower brake RTs and longer following distances compared with a control condition that was not threatened. This driving profile was characteristic of cognitive distraction. Stereotype threat has clear consequences for human performance in a common real-world task-driving-that is critical to public safety. Furthermore, these findings suggest caution in how the media and public policy communicate information about older adult driving. Copyright (c) 2015 John Wiley & Sons, Ltd. C1 [Lambert, Ann E.; Watson, Jason M.; Stefanucci, Jeanine K.; Ward, Nathan; Bakdash, Jonathan Z.; Strayer, David L.] Univ Utah, Dept Psychol, Salt Lake City, UT 84112 USA. [Watson, Jason M.] Univ Utah, Inst Brain, Salt Lake City, UT USA. [Watson, Jason M.] Univ Utah, Ctr Aging, Salt Lake City, UT USA. [Bakdash, Jonathan Z.] US Army, Res Lab, Adelphi, MD USA. RP Watson, JM (reprint author), Univ Colorado, Dept Psychol, Campus Box 173,POB 173364, Denver, CO 80217 USA. EM jason.watson@ucdenver.edu NR 39 TC 2 Z9 2 U1 3 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0888-4080 EI 1099-0720 J9 APPL COGNITIVE PSYCH JI Appl. Cogn. Psychol. PD JAN-FEB PY 2016 VL 30 IS 1 BP 22 EP 28 DI 10.1002/acp.3162 PG 7 WC Psychology, Experimental SC Psychology GA DH6FK UT WOS:000372886200003 ER PT J AU Davis, SJ Edwards, SB Teper, GE Bassett, DG McCarthy, MJ Johnson, SC Lawton, CR Hoffman, MJ Shelton, L Henry, SM Melander, DJ Muldoon, FM Alford, BD Rice, RE AF Davis, Scott J. Edwards, Shatiel B. Teper, Gerald E. Bassett, David G. McCarthy, Michael J. Johnson, Scott C. Lawton, Craig R. Hoffman, Matthew J. Shelton, Liliana Henry, Stephen M. Melander, Darryl J. Muldoon, Frank M. Alford, Brian D. Rice, Roy E. TI Maximizing the US Army's Future Contribution to Global Security Using the Capability Portfolio Analysis Tool (CPAT) SO INTERFACES LA English DT Article DE US Army; ground combat systems; portfolio optimization; fleet scheduling; decision support; mixed-integer linear programming AB Recent budget reductions have posed tremendous challenges to the U.S. Army in managing its portfolio of ground combat systems (tanks and other fighting vehicles), thus placing many important programs at risk. To address these challenges, the Army and a supporting team developed and applied the Capability Portfolio Analysis Tool (CPAT) to optimally invest in ground combat modernization over the next 25-35 years. CPAT provides the Army with the analytical rigor needed to help senior Army decision makers allocate scarce modernization dollars to protect soldiers and maintain capability overmatch. CPAT delivers unparalleled insight into multiple-decade modernization planning using a novel multiphase mixed-integer linear programming technique and illustrates a cultural shift toward analytics in the Army's acquisition thinking and processes. CPAT analysis helped shape decisions to continue modernization of the $10 billion Stryker family of vehicles (originally slated for cancellation) and to strategically reallocate over $20 billion to existing modernization programs by not pursuing the Ground Combat Vehicle program as originally envisioned. More than 40 studies have been completed using CPAT, applying operations research methods to optimally prioritize billions of taxpayer dollars and allowing Army acquisition executives to base investment decisions on analytically rigorous evaluations of portfolio trade-offs. C1 [Davis, Scott J.; Edwards, Shatiel B.; Teper, Gerald E.; Bassett, David G.; McCarthy, Michael J.; Johnson, Scott C.] United States Army, Warren, MI 48397 USA. [Lawton, Craig R.; Hoffman, Matthew J.; Shelton, Liliana; Henry, Stephen M.; Melander, Darryl J.; Muldoon, Frank M.] Sandia Natl Labs, POB 5800, Albuquerque, NM 87185 USA. [Alford, Brian D.] Booz Allen Hamilton, Huntsville, AL 35806 USA. [Rice, Roy E.] Teledyne Brown Engn Inc, Huntsville, AL 35805 USA. RP Davis, SJ; Edwards, SB; Teper, GE; Bassett, DG; McCarthy, MJ; Johnson, SC (reprint author), United States Army, Warren, MI 48397 USA.; Lawton, CR; Hoffman, MJ; Shelton, L; Henry, SM; Melander, DJ; Muldoon, FM (reprint author), Sandia Natl Labs, POB 5800, Albuquerque, NM 87185 USA.; Alford, BD (reprint author), Booz Allen Hamilton, Huntsville, AL 35806 USA.; Rice, RE (reprint author), Teledyne Brown Engn Inc, Huntsville, AL 35805 USA. EM scott.j.davis.civ@mail.mil; shatiel.b.edwards.civ@mail.mil; gerald.e.teper.civ@mail.mil; david.g.bassett.mil@mail.mil; michael.j.mccarthy.civ@mail.mil; scott.c.johnson98.civ@mail.mil; crlawto@sandia.gov; mjhoffm@sandia.gov; lshelto@sandia.gov; smhenry@sandia.gov; djmelan@sandia.gov; fmmuldo@sandia.gov; alford_brian@bah.com; roy.rice@teledyne.com FU U.S. Department of Energy's National Nuclear Security Administration [DE-AC04-94AL85000] FX The authors thank the Edelman selection committee, their coaches Randy Robinson and Greg Parlier, John Milne and Alice Mack for their valuable editorial feedback, Brent Peterson for his outstanding video production work, and David Cunnington and Daniel Thompson for their graphics and presentation expertise. The authors especially thank the Honorable Ms. Heidi Shyu and Lt. Gen. Michael Williamson for their video remarks supporting the impacts of the CPAT project. Sandia National Laboratories is a multiprogram laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration [Contract DE-AC04-94AL85000]. NR 12 TC 0 Z9 0 U1 2 U2 5 PU INFORMS PI CATONSVILLE PA 5521 RESEARCH PARK DR, SUITE 200, CATONSVILLE, MD 21228 USA SN 0092-2102 EI 1526-551X J9 INTERFACES JI Interfaces PD JAN-FEB PY 2016 VL 46 IS 1 SI SI BP 91 EP 108 DI 10.1287/inte.2015.0824 PG 18 WC Management; Operations Research & Management Science SC Business & Economics; Operations Research & Management Science GA DH9QN UT WOS:000373130900007 ER PT J AU Varghese, A Yakimov, M Tokranov, V Mitin, V Sablon, K Sergeev, A Oktyabrsky, S AF Varghese, A. Yakimov, M. Tokranov, V. Mitin, V. Sablon, K. Sergeev, A. Oktyabrsky, S. TI Complete voltage recovery in quantum dot solar cells due to suppression of electron capture SO NANOSCALE LA English DT Article ID BUILT-IN CHARGE; MULTIPHONON PROCESSES; RELAXATION; ENHANCEMENT; DEPENDENCE; EFFICIENCY; GAAS AB Extensive investigations in recent years have shown that addition of quantum dots (QDs) to a single-junction solar cell decreases the open circuit voltage, V-OC, with respect to the reference cell without QDs. Despite numerous efforts, the complete voltage recovery in QD cells has been demonstrated only at low temperatures. To minimize the V-OC reduction, we propose and investigate a new approach that combines nanoscale engineering of the band structure and the potential profile. Our studies of GaAs solar cells with various InAs QD media demonstrate that the main cause of the V-OC reduction is the fast capture of photoelectrons from the GaAs conduction band (CB) to the localized states in QDs. As the photoelectron capture into QDs is mainly realized via the wetting layers (WLs), we substantially reduced the WLs using two monolayer AlAs capping of QDs. In the structures with reduced WLs, the direct CB-to-QD capture is further suppressed due to charging of QDs via doping of the interdot space. The QD devices with suppressed photoelectron capture show the same V-OC as the GaAs reference cell together with some improvements in the short circuit current. C1 [Varghese, A.; Yakimov, M.; Tokranov, V.; Oktyabrsky, S.] SUNY Polytech Inst, Albany, NY 12203 USA. [Mitin, V.] SUNY Buffalo, Buffalo, NY 14260 USA. [Sablon, K.; Sergeev, A.] US Army Res Lab, Adelphi, MD 20783 USA. RP Sergeev, A (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM asergeev@buffalo.edu FU National Science Foundation [ECS-1236459]; NRC FX This research was supported by the National Science Foundation under grant ECS-1236459. AS acknowledges support from NRC. NR 43 TC 1 Z9 1 U1 2 U2 16 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2040-3364 EI 2040-3372 J9 NANOSCALE JI Nanoscale PY 2016 VL 8 IS 13 BP 7248 EP 7256 DI 10.1039/c5nr07774e PG 9 WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA DH8QO UT WOS:000373060600039 PM 26974517 ER PT J AU Kula, RR Harms, NE AF Kula, Robert R. Harms, Nathan E. TI A NEW SPECIES OF CHAENUSA HALIDAY SENSU LATO (HYMENOPTERA: BRACONIDAE) FROM THE NEARCTIC REGION SO PROCEEDINGS OF THE ENTOMOLOGICAL SOCIETY OF WASHINGTON LA English DT Article DE Alysiinae; biological control; Dacnusini; Hydrellia; parasitoid; Sagittaria latifolia; taxonomy ID DISTRIBUTION RECORDS; ALYSIINAE; REVISION; HYDROCHARITACEAE; DIPTERA AB Chaenusa psillosae Kula, new species from the Nearctic Region is described. Specimens upon which the new species is described were reared from an undetermined species of Hydrellia Robineau-Desvoidy infesting Sagittaria latifolia Willd. A key to the New World species of Chaenusa sensu lato is amended to include the new species. C1 [Kula, Robert R.] Smithsonian Inst, Systemat Entomol Lab, Beltsville Agr Res Ctr, Agr Res Serv,US Dept Agr,Natl Museum Nat Hist, POB 37012,MRC-168, Washington, DC 20013 USA. [Harms, Nathan E.] US Army, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Kula, RR (reprint author), Smithsonian Inst, Systemat Entomol Lab, Beltsville Agr Res Ctr, Agr Res Serv,US Dept Agr,Natl Museum Nat Hist, POB 37012,MRC-168, Washington, DC 20013 USA.; Harms, NE (reprint author), US Army, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. EM Robert.Kula@ars.usda.gov; Nathan.e.harms@usace.army.mil NR 15 TC 0 Z9 0 U1 0 U2 0 PU ENTOMOL SOC WASHINGTON PI WASHINGTON PA SMITHSONIAN INSTITUTION DEPT ENTOMOLOGY, WASHINGTON, DC 20560 USA SN 0013-8797 J9 P ENTOMOL SOC WASH JI Proc. Entomol. Soc. Wash. PD JAN PY 2016 VL 118 IS 1 BP 101 EP 108 DI 10.4289/0013-8797.118.1.101 PG 8 WC Entomology SC Entomology GA DI1FU UT WOS:000373242800006 ER PT J AU Caudle, KL Lu, XCM Mountney, A Shear, DA Tortella, FC AF Caudle, Krista L. Lu, Xi-Chun M. Mountney, Andrea Shear, Deborah A. Tortella, Frank C. TI Neuroprotection and anti-seizure effects of levetiracetam in a rat model of penetrating ballistic-like brain injury SO RESTORATIVE NEUROLOGY AND NEUROSCIENCE LA English DT Article DE Traumatic brain injury; post-traumatic seizures; neuroprotection; motor; cognitive function; rat ID ANTICONVULSANT DRUG LEVETIRACETAM; ACUTE NONCONVULSIVE SEIZURES; CEREBRAL-ARTERY OCCLUSION; CRITICALLY-ILL ADULTS; INTRAVENOUS LEVETIRACETAM; SUBARACHNOID HEMORRHAGE; ELECTROGRAPHIC SEIZURES; BARRIER PERMEABILITY; CONSENSUS STATEMENT; CORTICAL DYSPLASIA AB Purpose: We assessed the therapeutic efficacy of FDA-approved anti-epileptic drug Levetiracetam (LEV) to reduce post-traumatic nonconvulsive seizure (NCS) activity and promote neurobehavioral recovery following 10% frontal penetrating ballistic-like brain injury (PBBI) in male Sprague-Dawley rats. Methods: Experiment 1 anti-seizure study: 50 mg/kg LEV (25 mg/kg maintenance doses) was given twice daily for 3 days (LEV3D) following PBBI; outcome measures included seizures incidence, frequency, duration, and onset. Experiment 2 neuroprotection studies: 50 mg/kg LEV was given twice daily for either 3 (LEV3D) or 10 days (LEV10D) post-injury; outcome measures include motor (rotarod) and cognitive (water maze) functions. Results: LEV3D treatment attenuated seizure activity with significant reductions in NCS incidence (54%), frequency, duration, and delayed latency to seizure onset compared to vehicle treatment. LEV3D treatment failed to improve cognitive or motor performance; however extending the dosing regimen through 10 days post-injury afforded significant neuroprotective benefit. Animals treated with the extended LEV10D dosing regimen showed a twofold improvement in rotarod task latency to fall as well as significantly improved spatial learning performance (24%) in the MWM task. Conclusions: These findings support the dual anti-seizure and neuroprotective role of LEV, but more importantly identify the importance of an extended dosing protocol which was specific to the therapeutic targets studied. C1 [Caudle, Krista L.; Lu, Xi-Chun M.; Mountney, Andrea; Shear, Deborah A.; Tortella, Frank C.] Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat Branch, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. RP Caudle, KL (reprint author), Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat Branch, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM krista.l.caudle.civ@mail.mil FU United States Army [W81XWH-10-1-0623] FX This work was supported by the United States Army [grant number W81XWH-10-1-0623]. NR 55 TC 0 Z9 0 U1 0 U2 2 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 0922-6028 EI 1878-3627 J9 RESTOR NEUROL NEUROS JI Restor. Neurol. Neurosci. PY 2016 VL 34 IS 2 BP 257 EP 270 DI 10.3233/RNN-150580 PG 14 WC Neurosciences SC Neurosciences & Neurology GA DI3JG UT WOS:000373394300009 PM 26890099 ER PT J AU Meyer, ES Characklis, GW Brown, C Moody, P AF Meyer, Eliot S. Characklis, Gregory W. Brown, Casey Moody, Paul TI Hedging the financial risk from water scarcity for Great Lakes shipping SO WATER RESOURCES RESEARCH LA English DT Article ID WEATHER INDEX INSURANCE; COST-EFFECTIVENESS; CLIMATE-CHANGE; DROUGHT; PRECIPITATION; TRANSPORT; REGION AB Low water levels in the Great Lakes have recently had significant financial impacts on the region's commercial shipping, which transports hundreds of millions of dollars' worth of bulk goods each year. Cargo capacity is a function of a ship's draft, the distance between water level and the ship's bottom, and lower water levels force ships to reduce cargo loads to prevent running aground in shallow harbors and locks. Financial risk transfer instruments, such as index-based insurance contracts, may provide an adaptable method for managing these financial risks. In this work, a relationship between water levels and shipping revenues is developed and used in an actuarial analysis of the frequency and magnitude of revenue losses. This analysis is used to develop a standardized suite of binary financial contracts, which are indexed to water levels and priced according to predefined thresholds. These contracts are then combined to form hedging portfolios with different objectives for the shippers. Results suggest that binary contracts could substantially reduce the risk of financial losses during low lake level periods and at a relatively low cost of only one to three percent of total revenues, depending on coverage level. C1 [Meyer, Eliot S.; Characklis, Gregory W.] Univ N Carolina, Dept Environm Sci & Engn, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. [Brown, Casey] Univ Massachusetts, Dept Civil & Environm Engn, Amherst, MA 01003 USA. [Moody, Paul] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. RP Meyer, ES (reprint author), Univ N Carolina, Dept Environm Sci & Engn, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. EM eliot.meyer@unc.edu FU Hydro Research Foundation; Center for Watershed Science and Management (UNC) a part of the University of North Carolina's Institute for the Environment FX This research could not have been completed without the help of William Werick, the U.S. Army Corps of Engineers, the International Upper Great Lakes Study (IUGLS), and Andrew Gronewold. It was undertaken with the financial support of the Hydro Research Foundation and the Center for Watershed Science and Management (UNC), a part of the University of North Carolina's Institute for the Environment. All raw data used in this analysis can be found online. Historic lake levels are found through NOAA's GLERL (http://www.glerl.noaa.gov/data/dashboard/GLWLD.html), historic NBS data from IUGLS (http://www.iugls.org/tags?tag_id=438), as well as stochastic NBS (http://www.iugls.org/tags?tag_id=438). NR 64 TC 0 Z9 0 U1 3 U2 9 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0043-1397 EI 1944-7973 J9 WATER RESOUR RES JI Water Resour. Res. PD JAN PY 2016 VL 52 IS 1 BP 227 EP 245 DI 10.1002/2015WR017855 PG 19 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA DH9LO UT WOS:000373117800014 ER PT J AU Qian, LW Fourcaudot, AB Yamane, K You, T Chan, RK Leung, KP AF Qian, Li-Wu Fourcaudot, Andrea B. Yamane, Kazuyoshi You, Tao Chan, Rodney K. Leung, Kai P. TI Exacerbated and prolonged inflammation impairs wound healing and increases scarring SO WOUND REPAIR AND REGENERATION LA English DT Article ID RABBIT EAR; INJURY RESPONSES; DIABETIC WOUNDS; MODEL; REDUCTION; PRIVILEGE; THERAPY; DANGER; MATTER; REPAIR AB Altered inflammation in the early stage has long been assumed to affect subsequent steps of the repair process that could influence proper wound healing and remodeling. However, the lack of explicit experimental data makes the connection between dysregulated wound inflammation and poor wound healing elusive. To bridge this gap, we used the established rabbit ear hypertrophic scar model for studying the causal effect of dysregulated inflammation. We induced an exacerbated and prolonged inflammatory state in these wounds with the combination of trauma-related stimulators of pathogen-associated molecular patterns from heat-killed Pseudomonas aeruginosa and damage-associated molecular patterns from a dermal homogenate. In stimulated wounds, a heightened and lengthened inflammation was observed based on quantitative measurements of IL-6 expression, tissue polymorphonuclear leukocytes infiltration, and tissue myeloperoxidase activity. Along with the high level of inflammation, wound healing parameters (epithelial gap and others) at postoperative day 7 and 16 were significantly altered in stimulated wounds compared to unstimulated controls. By postoperative day 35, scar elevation of stimulated wounds was higher than that of control wounds (scar elevation index: 1.90 vs. 1.39, p<0.01). Moreover, treatment of these inflamed wounds with Indomethacin (at concentrations of 0.01, 0.1, and 0.4%) reduced scar elevation but with adverse effects of delayed wound closure and increased cartilage hypertrophy. In summary, successful establishment of this inflamed wound model provides a platform to understand these detrimental aspects of unchecked inflammation and to further test agents that can modulate local inflammation to improve wound outcomes. C1 [Qian, Li-Wu; Fourcaudot, Andrea B.; Yamane, Kazuyoshi; You, Tao; Chan, Rodney K.; Leung, Kai P.] US Army, Inst Surg Res, Dent & Trauma Res Detachment, 3698 Chambers Pass,Bldg 3610, Ft Sam Houston, TX 78234 USA. RP Leung, KP (reprint author), US Army, Inst Surg Res, Dent & Trauma Res Detachment, 3698 Chambers Pass,Bldg 3610, Ft Sam Houston, TX 78234 USA. EM kai.p.leung.civ@mail.mil FU US Army Medical Research and Material Command, Combat Casualty Care Research Directorate FX This work was supported by the US Army Medical Research and Material Command, Combat Casualty Care Research Directorate. NR 33 TC 8 Z9 8 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1067-1927 EI 1524-475X J9 WOUND REPAIR REGEN JI Wound Repair Regen. PD JAN-FEB PY 2016 VL 24 IS 1 BP 26 EP 34 DI 10.1111/wrr.12381 PG 9 WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery GA DH6TT UT WOS:000372925500003 PM 26562746 ER PT J AU DeCoste, JB Denny, MS Peterson, GW Mahle, JJ Cohen, SM AF DeCoste, Jared B. Denny, Michael S., Jr. Peterson, Gregory W. Mahle, John J. Cohen, Seth M. TI Enhanced aging properties of HKUST-1 in hydrophobic mixed-matrix membranes for ammonia adsorption SO CHEMICAL SCIENCE LA English DT Article ID METAL-ORGANIC FRAMEWORKS; REMOVAL; CU-3(BTC)(2); COMPOSITES; SURFACES; STORAGE; MOF AB Metal-organic frameworks (MOFs) in their free powder form have exhibited superior capacities for many gases when compared to other materials, due to their tailorable functionality and high surface areas. Specifically, the MOF HKUST-1 binds small Lewis bases, such as ammonia, with its coordinatively unsaturated copper sites. We describe here the use of HKUST-1 in mixed-matrix membranes (MMMs) prepared from polyvinylidene difluoride (PVDF) for the removal of ammonia gas. These MMMs exhibit ammonia capacities similar to their hypothetical capacities based on the weight percent of HKUST-1 in each MMM. HKUST-1 in its powder form is unstable toward humid conditions; however, upon exposure to humid environments for prolonged periods of time, the HKUST-1 MMMs exhibit outstanding structural stability, and maintain their ammonia capacity. Overall, this study has achieved all of the critical and combined elements for real-world applications of MOFs: high MOF loadings, fully accessible MOF surfaces, enhanced MOF stabilization, recyclability, mechanical stability, and processability. This study is a critical step in advancing MOFs to a stable, usable, and enabling technology. C1 [DeCoste, Jared B.; Peterson, Gregory W.; Mahle, John J.; Cohen, Seth M.] US Army Res Dev & Engn Command, Edgewood Chem Biol Ctr, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. [DeCoste, Jared B.] Leidos Inc, POB 68, Gunpowder, MD 21010 USA. [Denny, Michael S., Jr.; Cohen, Seth M.] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA. RP DeCoste, JB; Cohen, SM (reprint author), US Army Res Dev & Engn Command, Edgewood Chem Biol Ctr, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.; DeCoste, JB (reprint author), Leidos Inc, POB 68, Gunpowder, MD 21010 USA.; Cohen, SM (reprint author), Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA. EM jared.b.decoste2.civ@mail.mil; scohen@ucsd.edu OI Cohen, Seth/0000-0002-5233-2280 FU Joint Science and Technology Office for Chemical Biological Defense [BA07PRO104]; Army Research Office [W911NF-15-1-0189] FX J. B. D., G. W. P. and J. J. M. thank the Joint Science and Technology Office for Chemical Biological Defense for funding under project number BA07PRO104. M. S. D. and S. M. C. acknowledge support from the Army Research Office award number W911NF-15-1-0189. All authors thank Mr Matthew Browe for conducting microbreakthrough experiments. NR 36 TC 7 Z9 7 U1 27 U2 80 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2041-6520 EI 2041-6539 J9 CHEM SCI JI Chem. Sci. PY 2016 VL 7 IS 4 BP 2711 EP 2716 DI 10.1039/c5sc04368a PG 6 WC Chemistry, Multidisciplinary SC Chemistry GA DH2KQ UT WOS:000372614800032 ER PT J AU Ramon, ES Tyo, JS Ziolkowski, RW Skipper, MC Abdalla, MD Martin, J AF Ramon, Eric S. Tyo, J. Scott Ziolkowski, Richard W. Skipper, Michael C. Abdalla, Michael D. Martin, Joshua TI Integration and Operation of an Electrically Small Magnetic EZ Antenna With a High-Power Standing Wave Oscillator Source SO IEEE ANTENNAS AND WIRELESS PROPAGATION LETTERS LA English DT Article DE Antennas; dipole antennas; high power micro-wave generation; pulse power systems AB The efficacy of the three-dimensional, rectangular magnetic EZ antenna for use with mesoband high-power microwave (HPM) sources has been demonstrated previously. It overcomes the typical bulky and massive impedance-matching components found currently in most HPM systems, making it an attractive option when space is very limited. However, its extremely compact nature presents practical challenges when dealing with extremely high-power sources due to the associated local field enhancements near the feed and the near-field resonant parasitic element. This letter presents a fully integrated, high-voltage source and radiating system that has several improvements in the antenna, source, and power system that have not before been demonstrated. The full system includes a ferroelectric generator, standing wave oscillator source, and electrically small antenna (ka = 0.37) operating at 510 MHz that can be packaged inside a 15-cm-diameter tube. This small diameter results in a quarter-wavelength-diameter ground plane, and the effects of this small ground plane on the radiation characteristics are explored. The development of a pressurized radome allows for operation at 73.6 kV, significantly higher than previous studies. C1 [Ramon, Eric S.; Ziolkowski, Richard W.] Univ Arizona, Coll Opt Sci, Tucson, AZ 85721 USA. [Ramon, Eric S.; Ziolkowski, Richard W.] Univ Arizona, Dept Elect & Comp Engn, Tucson, AZ 85721 USA. [Tyo, J. Scott] Univ New South Wales Canberra, Sch Engn & Informat Technol, Canberra, ACT 2600, Australia. [Skipper, Michael C.; Abdalla, Michael D.] ASR Corp, Albuquerque, NM 87048 USA. [Martin, Joshua] US Army, Space & Missile Def Command, Huntsville, AL 35649 USA. RP Tyo, JS (reprint author), Univ New South Wales Canberra, Sch Engn & Informat Technol, Canberra, ACT 2600, Australia. EM tyo@ieee.org NR 20 TC 0 Z9 0 U1 3 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1536-1225 EI 1548-5757 J9 IEEE ANTENN WIREL PR JI IEEE Antennas Wirel. Propag. Lett. PY 2016 VL 15 BP 642 EP 645 DI 10.1109/LAWP.2015.2465869 PG 4 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA DH2YS UT WOS:000372654100009 ER PT J AU Choi, JH Dagefu, FT Sadler, BM Sarabandi, K AF Choi, Jihun Dagefu, Fikadu T. Sadler, Brian M. Sarabandi, Kamal TI Electrically Small Folded Dipole Antenna for HF and Low-VHF Bands SO IEEE ANTENNAS AND WIRELESS PROPAGATION LETTERS LA English DT Article DE Antenna design; antenna fabrication; antenna measurement; electrically small antennas; folded dipole; low-VHF antennas ID MINIATURIZATION AB A novel, highly miniaturized, lightweight antenna operating at the low-VHF band is presented. Earlier studies on an extremely short HF monopole antenna consisting of two in-phase vertical elements face an inevitable issue regarding an unbalanced coaxial cable feed due to the very small ground plane [1]. To resolve this problem, as well as to achieve higher bandwidth, we introduce an electrically small folded dipole version of the same antenna having a fully balanced structure. The overall dimension and total mass of the proposed antenna are 10 x 10 x 15 cm(3). (0.013 lambda(0) x 0.013 lambda(0) x 0.02 lambda(0) at 40 MHz) and 98 g, respectively. The gain and pattern of the fabricated antenna are measured in an elevated range that is in nearly free-space conditions. Measurements are shown to be in good agreement with the design predictions from simulation. C1 [Choi, Jihun; Sarabandi, Kamal] Univ Michigan, Dept Elect Engn & Comp Sci, Radiat Lab, Ann Arbor, MI 48109 USA. [Dagefu, Fikadu T.; Sadler, Brian M.] Army Res Lab, Adelphi, MD 20783 USA. RP Choi, JH; Sarabandi, K (reprint author), Univ Michigan, Dept Elect Engn & Comp Sci, Radiat Lab, Ann Arbor, MI 48109 USA. EM jihchoi@umich.edu; saraband@eecs.umich.edu FU U.S. Army Research Laboratory [W911NF] FX This work was supported by the U.S. Army Research Laboratory under Contract W911NF and prepared through collaborative participation in the Microelectronics Center of Micro Autonomous Systems and Technology (MAST) Collaborative Technology Alliance (CTA). NR 12 TC 2 Z9 2 U1 1 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1536-1225 EI 1548-5757 J9 IEEE ANTENN WIREL PR JI IEEE Antennas Wirel. Propag. Lett. PY 2016 VL 15 BP 718 EP 721 DI 10.1109/LAWP.2015.2470215 PG 4 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA DH2YS UT WOS:000372654100028 ER PT J AU Barrett, DM Swanson, EP AF Barrett, David M. Swanson, Eric P. TI Did the CIA Reproduce 'Soviet Satellite' Imagery of the US During DCI McCone's Era? Evidence from a Document at the National Archives SO INTELLIGENCE AND NATIONAL SECURITY LA English DT Editorial Material AB The US developed the capability to see and reproduce photo imagery taken by Soviet satellites crossing the American landmass, according to notes of a conversation between DCI John McCone and Secretary of State Dean Rusk in 1963. We analyze the implications of this conversation, and report results of a literature search to explore how the US might have developed such a capability, and whether it lasted. C1 [Barrett, David M.] Villanova Univ, Polit Sci, Philadelphia, PA USA. [Swanson, Eric P.] US Army, Airborne Div 82, Adelphi, MD USA. [Swanson, Eric P.] NATOs Int Secur Assistance Force, Kabul, Afghanistan. RP Barrett, DM (reprint author), Villanova Univ, Polit Sci, Philadelphia, PA USA. EM david.barrett@villanova.edu NR 10 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0268-4527 EI 1743-9019 J9 INTELL NATL SECUR JI Intell. Natl. Secur. PY 2016 VL 31 IS 1 BP 131 EP 135 DI 10.1080/02684527.2015.1082241 PG 5 WC International Relations SC International Relations GA DH1HI UT WOS:000372534600009 ER PT J AU Cook, MT Auxier, JD Giminaro, AV Molgaard, JJ Knowles, JR Hall, HL AF Cook, Matthew T. Auxier, John D., II Giminaro, Andrew V. Molgaard, Joshua J. Knowles, Justin R. Hall, Howard L. TI A comparison of gamma spectra from trinitite versus irradiated synthetic nuclear melt glass SO JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY LA English DT Article DE Debris; Nuclear weapons; Nuclear forensics; Trinitite; Melt glass; Gamma spectroscopy ID DEVICE AB The development of realistic nuclear melt glass surrogates is important to the nuclear forensics community in order to establish analytical protocols for post-detonation analysis. In addition to creating surrogates that are accurate with regard to physical morphology and chemical composition, it is important to develop surrogates that also have similar radiological characteristics. A synthetic melt glass sample was irradiated at the High-Flux Isotope Reactor at Oak Ridge National Laboratory. This sample was counted twice using a semiconductor radiation detector to capture both fission-product signatures as well as those from neutron activation. A qualitative and quantitative analysis was performed to make recommendations for the next irradiation campaign. C1 [Cook, Matthew T.; Auxier, John D., II; Giminaro, Andrew V.; Hall, Howard L.] Univ Tennessee, Dept Nucl Engn, Knoxville, TN 37996 USA. [Auxier, John D., II; Hall, Howard L.] Univ Tennessee, Radiochem Ctr Excellence RCOE, Knoxville, TN 37996 USA. [Cook, Matthew T.; Auxier, John D., II; Giminaro, Andrew V.; Hall, Howard L.] Univ Tennessee, Inst Nucl Secur, Knoxville, TN 37996 USA. [Molgaard, Joshua J.] US Mil Acad, West Point, NY 10996 USA. [Knowles, Justin R.] Bredesen Ctr Interdisciplinary Res & Grad Educ, Knoxville, TN 37996 USA. RP Cook, MT (reprint author), Univ Tennessee, Dept Nucl Engn, Knoxville, TN 37996 USA.; Cook, MT (reprint author), Univ Tennessee, Inst Nucl Secur, Knoxville, TN 37996 USA. EM mcook4@vols.utk.edu OI Cook, Matthew/0000-0002-3460-5011; Knowles, Justin/0000-0001-7396-137X; Hall, Howard/0000-0002-4080-5159; Auxier II, John /0000-0001-6234-6451 FU Stewardship Science Academic Alliances (SSAA) Program of the U.S. Department of Energy (DOE) National Nuclear Security Administration (NNSA) [DE-NA000198] FX This work was performed under grant DE-NA000198 from the Stewardship Science Academic Alliances (SSAA) Program of the U.S. Department of Energy (DOE) National Nuclear Security Administration (NNSA). All views, opinions, and findings are those of the authors and do not necessary reflect those of the DOE and the NNSA. The authors would also like to gratefully acknowledge the efforts of Mr. David Glasgow of the HFIR at ORNL for their help in irradiating the surrogate samples and subsequent gamma-ray measurements. NR 13 TC 0 Z9 0 U1 2 U2 9 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0236-5731 EI 1588-2780 J9 J RADIOANAL NUCL CH JI J. Radioanal. Nucl. Chem. PD JAN PY 2016 VL 307 IS 1 BP 259 EP 267 DI 10.1007/s10967-015-4266-3 PG 9 WC Chemistry, Analytical; Chemistry, Inorganic & Nuclear; Nuclear Science & Technology SC Chemistry; Nuclear Science & Technology GA DG7LD UT WOS:000372264900035 ER PT J AU Zhang, SS Tran, DT AF Zhang, Sheng S. Tran, Dat T. TI Pyrite FeS2 as an efficient adsorbent of lithium polysulphide for improved lithium-sulphur batteries SO JOURNAL OF MATERIALS CHEMISTRY A LA English DT Article ID LI-S BATTERY; CATHODES; PERFORMANCE; CHEMISTRY; REDOX; GRAPHENE; SURFACE; CELLS; NANOSHEETS; NITROGEN AB Pyrite FeS2 chemically combines lithium polysulphide (Li2Sn) to form active Li2FeS2+n complexes that substantially reduce the out-diffusion of dissolved Li2Sn from sulphur cathodes and consequently improve the cycling performance of lithium-sulphur batteries. The same functions are also applicable to other transition metal sulphides, which opens a new direction for polysulphide sequestration in lithium-sulphur batteries. C1 [Zhang, Sheng S.; Tran, Dat T.] US Army Res Lab, Energy & Power Div, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), US Army Res Lab, Energy & Power Div, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. EM shengshui.zhang.civ@mail.mil RI Zhang, Sheng/A-4456-2012 OI Zhang, Sheng/0000-0003-4435-4110 NR 51 TC 9 Z9 9 U1 54 U2 113 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2050-7488 EI 2050-7496 J9 J MATER CHEM A JI J. Mater. Chem. A PY 2016 VL 4 IS 12 BP 4371 EP 4374 DI 10.1039/c6ta01214k PG 4 WC Chemistry, Physical; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Energy & Fuels; Materials Science GA DG6JQ UT WOS:000372190800004 ER PT J AU Alves, DA Honko, AN Kortepeter, MG Sun, M Johnson, JC Lugo-Roman, LA Hensley, LE AF Alves, Derron A. Honko, Anna N. Kortepeter, Mark G. Sun, Mei Johnson, Joshua C. Lugo-Roman, Luis A. Hensley, Lisa E. TI Necrotizing Scleritis, Conjunctivitis, and Other Pathologic Findings in the Left Eye and Brain of an Ebola Virus-Infected Rhesus Macaque (Macaca mulatta) With Apparent Recovery and a Delayed Time of Death SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE Ebola virus disease; Ebola virus; sequelae; macaque; rhesus; intramuscular; delayed death; eye; brain ID HEMORRHAGIC-FEVER; ZAIRE-EBOLAVIRUS; CONGO; KIKWIT AB A 3.5-year-old adult female rhesus macaque (Macaca mulatta) manifested swelling of the left upper eyelid and conjunctiva and a decline in clinical condition 18 days following intramuscular challenge with Ebola virus (EBOV; Kikwit-1995), after apparent clinical recovery. Histologic lesions with strong EBOV antigen staining were noted in the left eye (scleritis, conjunctivitis, and peri-optic neuritis), brain (choriomeningoencephalitis), stomach, proximal duodenum, and pancreas. Spleen, liver, and adrenal glands, common targets for acute infection, appeared histologically normal with no evidence of EBOV immunoreactivity. These findings may provide important insight for understanding sequelae seen in West African survivors of Ebola virus disease. C1 [Alves, Derron A.] Def Hlth Agcy, Def Hlth Headquarters, Vet Serv, 7700 Arlington Blvd, Falls Church, VA 22042 USA. [Honko, Anna N.; Johnson, Joshua C.; Hensley, Lisa E.] NIAID, Integrated Res Facil, NIH, Ft Detrick, MD USA. [Kortepeter, Mark G.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Sun, Mei] US Army, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. [Lugo-Roman, Luis A.] US Army, Med Res Inst Infect Dis, Vet Med Div, Ft Detrick, MD 21702 USA. RP Alves, DA (reprint author), Def Hlth Agcy, Def Hlth Headquarters, Vet Serv, 7700 Arlington Blvd, Falls Church, VA 22042 USA. EM derron.a.alves.mil@mail.mil OI Honko, Anna/0000-0001-9165-148X FU Defense Threat Reduction Agency [4.10033_07_RD_B] FX This work was supported by the Defense Threat Reduction Agency (project 4.10033_07_RD_B). NR 15 TC 3 Z9 3 U1 0 U2 4 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD JAN 1 PY 2016 VL 213 IS 1 BP 57 EP 60 DI 10.1093/infdis/jiv357 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA DF2EG UT WOS:000371152700009 PM 26153408 ER PT S AU Doepker, C Lieberman, HR Smith, AP Peck, JD El-Sohemy, A Welsh, BT AF Doepker, Candace Lieberman, Harris R. Smith, Andrew Paul Peck, Jennifer D. El-Sohemy, Ahmed Welsh, Brian T. BE Doyle, MP Klaenhammer, TR TI Caffeine: Friend or Foe? SO ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 7 SE Annual Review of Food Science and Technology LA English DT Review; Book Chapter DE cardiovascular; pharmacology; reproductive; behavior; benefits; regulation ID CORONARY-HEART-DISEASE; COFFEE CONSUMPTION; MYOCARDIAL-INFARCTION; ENERGY DRINKS; UNITED-STATES; SPONTANEOUS-ABORTION; RISK-FACTORS; CARDIOVASCULAR-DISEASES; EPIDEMIOLOGIC EVIDENCE; ADENOSINE RECEPTORS AB The debate on the safety of and regulatory approaches for caffeine continues among various stakeholders and regulatory authorities. This decision-making process comes with significant challenges, particularly when considering the complexities of the available scientific data, making the formulation of clear science-based regulatory guidance more difficult. To allow for discussions of a number of key issues, the North American Branch of the International Life Sciences Institute (ILSI) convened a panel of subject matter experts for a caffeine-focused session entitled "Caffeine: Friend or Foe?," which was held during the 2015 ILSI Annual Meeting. The panelists' expertise covered topics ranging from the natural occurrence of caffeine in plants and interindividual metabolism of caffeine in humans to specific behavioral, reproductive, and cardiovascular effects related to caffeine consumption. Each presentation highlighted the potential risks, benefits, and challenges that inform whether caffeine exposure warrants concern. This paper aims to summarize the key topics discussed during the session. C1 [Doepker, Candace; Welsh, Brian T.] ToxStrategies Inc, Austin, TX 78759 USA. [Lieberman, Harris R.] US Army Res Inst Environm Med, Natick, MA 01760 USA. [Smith, Andrew Paul] Cardiff Univ, Sch Psychol, Ctr Occupat & Hlth Psychol, Cardiff CF10 3AS, S Glam, Wales. [Peck, Jennifer D.] Univ Oklahoma, Hlth Sci Ctr, Coll Publ Hlth, Dept Biostat & Epidemiol, Oklahoma City, OK 73104 USA. [Smith, Andrew Paul; El-Sohemy, Ahmed] Univ Toronto, Dept Nutr Sci, Toronto, ON M5S 3E2, Canada. RP Doepker, C (reprint author), ToxStrategies Inc, Austin, TX 78759 USA.; Lieberman, HR (reprint author), US Army Res Inst Environm Med, Natick, MA 01760 USA.; Smith, AP (reprint author), Cardiff Univ, Sch Psychol, Ctr Occupat & Hlth Psychol, Cardiff CF10 3AS, S Glam, Wales.; Peck, JD (reprint author), Univ Oklahoma, Hlth Sci Ctr, Coll Publ Hlth, Dept Biostat & Epidemiol, Oklahoma City, OK 73104 USA.; El-Sohemy, A (reprint author), Univ Toronto, Dept Nutr Sci, Toronto, ON M5S 3E2, Canada. EM cdoepker@toxstrategies.com; harris.r.lieberman.civ@mail.mil; smithap@cardiff.ac.uk; jennifer-peck@ouhsc.edu; a.el.sohemy@utoronto.ca NR 141 TC 2 Z9 2 U1 13 U2 63 PU ANNUAL REVIEWS PI PALO ALTO PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA SN 1941-1413 BN 978-0-8243-4907-3 J9 ANNU REV FOOD SCI T JI Annu. Rev. Food Sci. Technol. PY 2016 VL 7 BP 117 EP 137 DI 10.1146/annurev-food-041715-033243 PG 21 WC Food Science & Technology SC Food Science & Technology GA BE3ZR UT WOS:000371430700006 PM 26735800 ER PT J AU Kotwal, RS Howard, JT Orman, JA Tarpey, BW Bailey, JA Champion, HR Mabry, RL Holcomb, JB Gross, KR AF Kotwal, Russ S. Howard, Jeffrey T. Orman, Jean A. Tarpey, Bruce W. Bailey, Jeffrey A. Champion, Howard R. Mabry, Robert L. Holcomb, John B. Gross, Kirby R. TI The Effect of a Golden Hour Policy on the Morbidity and Mortality of Combat Casualties SO JAMA SURGERY LA English DT Article ID PREHOSPITAL TIME; TRAUMA; CARE; BATTLEFIELD; EVACUATION; INJURY; VIETNAM; IMPACT; DEATH; AFGHANISTAN AB IMPORTANCE The term golden hour was coined to encourage urgency of trauma care. In 2009, Secretary of Defense Robert M. Gates mandated prehospital helicopter transport of critically injured combat casualties in 60 minutes or less. OBJECTIVES To compare morbidity and mortality outcomes for casualties before vs after the mandate and for those who underwent prehospital helicopter transport in 60 minutes or less vs more than 60 minutes. DESIGN, SETTING, AND PARTICIPANTS A retrospective descriptive analysis of battlefield data examined 21 089 US military casualties that occurred during the Afghanistan conflict from September 11, 2001, to March 31, 2014. Analysis was conducted from September 1, 2014, to January 21, 2015. MAIN OUTCOMES AND MEASURES Data for all casualties were analyzed according to whether they occurred before or after the mandate. Detailed data for those who underwent prehospital helicopter transport were analyzed according to whether they occurred before or after the mandate and whether they occurred in 60 minutes or less vs more than 60 minutes. Casualties with minor wounds were excluded. Mortality and morbidity outcomes and treatment capability-related variables were compared. RESULTS For the total casualty population, the percentage killed in action (16.0%[386 of 2411] vs 9.9% [964 of 9755]; P<.001) and the case fatality rate ([CFR] 13.7 [469 of 3429] vs 7.6 [1344 of 17 660]; P<.001) were higher before vs after the mandate, while the percentage died of wounds (4.1%[83 of 2025] vs 4.3%[380 of 8791]; P=.71) remained unchanged. Decline in CFR after the mandate was associated with an increasing percentage of casualties transported in 60 minutes or less (regression coefficient, -0.141; P<.001), with projected vs actual CFR equating to 359 lives saved. Among 4542 casualties (mean injury severity score, 17.3; mortality, 10.1%[457 of 4542]) with detailed data, there was a decrease in median transport time after the mandate (90 min vs 43 min; P<.001) and an increase in missions achieving prehospital helicopter transport in 60 minutes or less (24.8%[181 of 731] vs 75.2% [2867 of 3811]; P<.001). When adjusted for injury severity score and time period, the percentage killed in action was lower for those critically injured who received a blood transfusion (6.8%[40 of 589] vs 51.0% [249 of 488]; P<.001) and were transported in 60 minutes or less (25.7%[205 of 799] vs 30.2%[84 of 278]; P<.01), while the percentage died of wounds was lower among those critically injured initially treated by combat support hospitals (9.1%[48 of 530] vs 15.7%[86 of 547]; P<.01). Acute morbidity was higher among those critically injured who were transported in 60 minutes or less (36.9%[295 of 799] vs 27.3%[76 of 278]; P<.01), those severely and critically injured initially treated at combat support hospitals (severely injured, 51.1% [161 of 315] vs 33.1%[104 of 314]; P<.001; and critically injured, 39.8%[211 of 530] vs 29.3%[160 of 547]; P<.001), and casualties who received a blood transfusion (50.2%[618 of 1231] vs 3.7%[121 of 3311]; P<.001), emphasizing the need for timely advanced treatment. CONCLUSIONS AND RELEVANCE A mandate made in 2009 by Secretary of Defense Gates reduced the time between combat injury and receiving definitive care. Prehospital transport time and treatment capability are important factors for casualty survival on the battlefield. C1 [Kotwal, Russ S.; Howard, Jeffrey T.; Orman, Jean A.; Tarpey, Bruce W.; Bailey, Jeffrey A.; Mabry, Robert L.; Gross, Kirby R.] US Army Inst Surg Res, Joint Trauma Syst, 3698 Chambers Pass, Joint Base San Antonio F, TX 78234 USA. [Kotwal, Russ S.; Bailey, Jeffrey A.; Champion, Howard R.; Gross, Kirby R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Kotwal, Russ S.] Texas A&M Hlth Sci Ctr, Coll Med, College Stn, TX USA. [Holcomb, John B.] Univ Texas Med Sch, Ctr Translat Injury Res, Houston, TX USA. RP Kotwal, RS (reprint author), US Army Inst Surg Res, Joint Trauma Syst, 3698 Chambers Pass, Joint Base San Antonio F, TX 78234 USA. EM russ.kotwal@us.army.mil NR 43 TC 13 Z9 14 U1 3 U2 11 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6254 EI 2168-6262 J9 JAMA SURG JI JAMA Surg. PD JAN PY 2016 VL 151 IS 1 BP 15 EP 24 DI 10.1001/jamasurg.2015.3104 PG 10 WC Surgery SC Surgery GA DF4KD UT WOS:000371315800005 PM 26422778 ER PT J AU Rasmussen, TE AF Rasmussen, Todd E. TI The Power of Advanced Capability and Informed Policy SO JAMA SURGERY LA English DT Editorial Material C1 [Rasmussen, Todd E.] US Army, US Combat Casualty Care Res Program, 722 Doughten St,Room 3, Ft Detrick, MD 21702 USA. [Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. RP Rasmussen, TE (reprint author), US Army, US Combat Casualty Care Res Program, 722 Doughten St,Room 3, Ft Detrick, MD 21702 USA. EM todd.e.rasmussen.mil@mail.mil NR 5 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6254 EI 2168-6262 J9 JAMA SURG JI JAMA Surg. PD JAN PY 2016 VL 151 IS 1 BP 25 EP 25 DI 10.1001/jamasurg.2015.3111 PG 1 WC Surgery SC Surgery GA DF4KD UT WOS:000371315800006 PM 26422056 ER PT J AU Yan, T Li, ZH Li, YZ Qin, H AF Yan, Ting Li, Zhaohai Li, Yuanzhang Qin, Hong TI Likelihood ratio tests in the Rasch model for item response data when the number of persons and items goes to infinity SO STATISTICS AND ITS INTERFACE LA English DT Article DE Fisher information matrix; Likelihood ratio tests; Rasch model; Wilks type of results ID RANDOM-VARIABLES; RANDOM GRAPHS AB When the number of persons and items goes to infinity simultaneously, the maximum likelihood estimator in the Rasch model for dichotomous item response data has been shown to be consistency and asymptotic normality. However, the limiting distributions of the likelihood ratio tests in the past thirty years are still unknown. In this paper, we establish the Wilks type of results for the likelihood ratio tests under some simple and composite null hypotheses. Our proof crucially depends on the approximated inverse of the Fisher information matrix with small approximation errors. Simulation studies are provided to illustrate the asymptotic results. C1 [Yan, Ting; Qin, Hong] Cent China Normal Univ, Dept Stat, Wuhan 430079, Peoples R China. [Li, Zhaohai] George Washington Univ, Dept Stat, 2140 Penn Ave NW, Washington, DC 20052 USA. [Li, Yuanzhang] Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. RP Yan, T (reprint author), Cent China Normal Univ, Dept Stat, Wuhan 430079, Peoples R China. EM tingyanty@mail.ccnu.edu.cn; zli@gwu.edu; Liy.Li@us.army.mil; qinhong@mail.ccnu.edu.cn FU National Natural Science Foundation of China [11401239]; Postdoctoral Science Foundation of China [2014M552064] FX Yan's research was partially supported by the National Natural Science Foundation of China (No. 11401239) and Postdoctoral Science Foundation of China (No. 2014M552064). NR 28 TC 0 Z9 0 U1 1 U2 1 PU INT PRESS BOSTON, INC PI SOMERVILLE PA PO BOX 43502, SOMERVILLE, MA 02143 USA SN 1938-7989 EI 1938-7997 J9 STAT INTERFACE JI Stat. Interface PY 2016 VL 9 IS 2 BP 223 EP 232 PG 10 WC Mathematical & Computational Biology; Mathematics, Interdisciplinary Applications SC Mathematical & Computational Biology; Mathematics GA DF2RX UT WOS:000371192600009 ER PT J AU Taylor, D Bright, JA McGoven, C Hefford, C Kalafut, T Buckleton, J AF Taylor, Duncan Bright, Jo-Anne McGoven, Catherine Hefford, Christopher Kalafut, Tim Buckleton, John TI Validating multiplexes for use in conjunction with modern interpretation strategies SO FORENSIC SCIENCE INTERNATIONAL-GENETICS LA English DT Article DE Forensic DNA interpretation; GlobalFiler; Continuous DNA interpretation; STRmix; Modelling; DNA mixtures ID ALLELIC DROP-OUT; FORENSIC DNA PROFILES; MIXTURE INTERPRETATION; LOGISTIC-REGRESSION; STATISTICAL-MODEL; STR MULTIPLEXES; STUTTER; PROBABILITIES; LOCI; PERFORMANCE AB In response to requests from the forensic community, commercial companies are generating larger, more sensitive, and more discriminating STR multiplexes. These multiplexes are now applied to a wider range of samples including complex multi-person mixtures. In parallel there is an overdue reappraisal of profile interpretation methodology. Aspects of this reappraisal include 1. The need for a quantitative understanding of allele and stutter peak heights and their variability, 2. An interest in reassessing the utility of smaller peaks below the often used analytical threshold, 3. A need to understand not just the occurrence of peak drop-in but also the height distribution of such peaks, and 4. A need to understand the limitations of the multiplex-interpretation strategy pair implemented. In this work we present a full scheme for validation of a new multiplex that is suitable for informing modern interpretation practice. We predominantly use GlobalFiler (TM) as an example multiplex but we suggest that the aspects investigated here are fundamental to introducing any multiplex in the modern interpretation environment. (C) 2015 Elsevier Ireland Ltd. All rights reserved. C1 [Taylor, Duncan; Hefford, Christopher] Forens Sci South Australia, 21 Divett Pl, Adelaide, SA 5000, Australia. [Taylor, Duncan] Flinders Univ S Australia, Sch Biol Sci, GPO Box 2100, Adelaide, SA 5001, Australia. [Bright, Jo-Anne; McGoven, Catherine; Buckleton, John] Inst Environm Sci & Res Ltd, Private Bag 92021, Auckland 1142, New Zealand. [Kalafut, Tim] US Army, Criminal Investigat Lab, Def Forens Sci Ctr, Forest Pk, GA 30297 USA. RP Taylor, D (reprint author), Forens Sci South Australia, 21 Divett Pl, Adelaide, SA 5000, Australia. EM Duncan.Taylor@sa.gov.au OI Taylor, Duncan/0000-0003-0633-7424 FU US National Institute of Justice [2011-DN-BX-K541] FX This work was supported in part by grant 2011-DN-BX-K541 from the US National Institute of Justice. Points of view in this document are those of the authors and do not necessarily represent the official position or policies of the U.S. Department of Justice or the Departments of Defense and Army. Names of commercial manufacturers or products included are incidental only, and inclusion does not imply endorsement by the Departments of Defense. NR 47 TC 6 Z9 6 U1 7 U2 11 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 1872-4973 EI 1878-0326 J9 FORENSIC SCI INT-GEN JI Forensic Sci. Int.-Genet. PD JAN PY 2016 VL 20 BP 6 EP 19 DI 10.1016/j.fsigen.2015.09.011 PG 14 WC Genetics & Heredity; Medicine, Legal SC Genetics & Heredity; Legal Medicine GA DE7IY UT WOS:000370810600006 PM 26433484 ER PT J AU Zhang, SS Tran, DT AF Zhang, Sheng S. Tran, Dat T. TI Mechanism and Solution for the Capacity Fading of Li/FeS2 Battery SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID LITHIUM-ION BATTERIES; REDUCED GRAPHENE OXIDE; CATHODE MATERIAL; PYRITE FES2; ELECTROCHEMICAL CHARACTERISTICS; POLYMER ELECTROLYTE; ROOM-TEMPERATURE; ANODE MATERIALS; NATURAL PYRITE; SOLID-STATE AB Development of Li/FeS2 rechargeable batteries has been hampered by their short cycle life. In this paper, we start with the fundamental chemistry of FeS2 in a non-aqueous liquid electrolyte to analyze the capacity fading mechanism of Li/FeS2 batteries and propose three facile strategies for stabilizing capacity. It is repeatedly observed that the capacity fading of Li/FeS2 cells follows a general mode consisting of a fast fading stage as Region 1, a slow fading stage as Region 2, and an accelerated fading stage as Region 3. We found that Region 1 is mainly attributed to the dissolution of lithium polysulfide leading to the loss of sulfur active material, and that Region 3 is mainly associated with the poor morphology of Li deposition resulting in the localized electric circuit shortening. The powder-like, small and loose Li particles not only react with electrolyte solvents drying-out the cell but also penetrate across the separator shortening the cell. Based on the above finding, the cycle life of Li/FeS2 cells was improved by adding vinylene carbonate as the electrolyte additive, increasing mechanical pressure between two electrodes, and placing a carbon interlayer between the FeS2 cathode and separator, respectively. (C) The Author(s) 2016. Published by ECS. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License (CC BY, http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse of the work in any medium, provided the original work is properly cited. All rights reserved. C1 [Zhang, Sheng S.; Tran, Dat T.] US Army, Res Lab, Electrochem Branch, RDRL SED C,Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), US Army, Res Lab, Electrochem Branch, RDRL SED C,Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. EM shengshui.zhang.civ@mail.mil RI Zhang, Sheng/A-4456-2012 OI Zhang, Sheng/0000-0003-4435-4110 NR 51 TC 5 Z9 5 U1 25 U2 70 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 SOUTH MAIN STREET, PENNINGTON, NJ 08534 USA SN 0013-4651 EI 1945-7111 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PY 2016 VL 163 IS 5 BP A792 EP A797 DI 10.1149/2.0041606jes PG 6 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA DE8DT UT WOS:000370866700029 ER PT J AU Kaspar, RB Wittkopf, JA Woodroof, MD Armstrong, MJ Yan, YS AF Kaspar, Robert B. Wittkopf, Jarrid A. Woodroof, Mariah D. Armstrong, Matthew J. Yan, Yushan TI Reverse-Current Decay in Hydroxide Exchange Membrane Fuel Cells SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID OXYGEN REDUCTION; CARBON CORROSION; ELECTRODE; CATALYSTS; KINETICS; WATER AB In proton exchange membrane fuel cells (PEMFCs), the cathode carbon support corrodes during startup and shutdown by reverse-current decay (RCD). We show for the first time that hydroxide exchange membrane fuel cells (HEMFCs) also undergo RCD. We find that decreasing the oxygen reduction reaction (ORR) activity of the anode catalyst mitigates RCD: a Ru anode causes less corrosion than Pt, Ir, and Pd anodes, as expected from their ORR activities. After an intensive 6 h RCD test, an HEMFC based on Ru shows six times lower internal resistance compared to Pt (1.02 vs. 6.01 Omega cm(2)). Due to its enhanced ORR activity in base, carbon alone can sustain RCD. To minimize RCD the carbon support should be eliminated from the anode catalyst. (C) The Author(s) 2016. Published by ECS. All rights reserved. C1 [Kaspar, Robert B.; Wittkopf, Jarrid A.; Woodroof, Mariah D.; Yan, Yushan] Univ Delaware, Ctr Catalyt Sci & Technol, Dept Biomol & Chem Engn, Newark, DE 19716 USA. [Armstrong, Matthew J.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. RP Yan, YS (reprint author), Univ Delaware, Ctr Catalyt Sci & Technol, Dept Biomol & Chem Engn, Newark, DE 19716 USA. EM yanys@udel.edu FU Advanced Research Projects Agency-Energy (ARPA-E) [DE-AR0000009] FX This work was supported in part by the Advanced Research Projects Agency-Energy (ARPA-E) under award number DE-AR0000009. The authors thank A. N. Beris for assistance with the computational modeling. NR 26 TC 2 Z9 2 U1 6 U2 13 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 SOUTH MAIN STREET, PENNINGTON, NJ 08534 USA SN 0013-4651 EI 1945-7111 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PY 2016 VL 163 IS 5 BP F377 EP F383 DI 10.1149/2.041605jes PG 7 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA DE8DT UT WOS:000370866700087 ER PT J AU Tomaiuolo, M Kottke, M Matheny, RW Reifman, J Mitrophanov, AY AF Tomaiuolo, Maurizio Kottke, Melissa Matheny, Ronald W., Jr. Reifman, Jaques Mitrophanov, Alexander Y. TI Computational identification and analysis of signaling subnetworks with distinct functional roles in the regulation of TNF production SO MOLECULAR BIOSYSTEMS LA English DT Article ID NF-KAPPA-B; TUMOR-NECROSIS-FACTOR; TOLL-LIKE RECEPTOR; NEGATIVE REGULATOR; TEMPORAL CONTROL; IL-10 PRODUCTION; GENE-EXPRESSION; ANTIINFLAMMATORY RESPONSE; MOLECULAR-MECHANISMS; CHRONIC INFLAMMATION AB Inflammation is a complex process driven by the coordinated action of a vast number of pro- and anti-inflammatory molecular mediators. While experimental studies have provided an abundance of information about the properties and mechanisms of action of individual mediators, essential system-level regulatory patterns that determine the time-course of inflammation are not sufficiently understood. In particular, it is not known how the contributions from distinct signaling pathways involved in cytokine regulation combine to shape the overall inflammatory response over different time scales. We investigated the kinetics of the intra- and extracellular signaling network controlling the production of the essential pro- inflammatory cytokine, tumor necrosis factor (TNF), and its anti-inflammatory counterpart, interleukin 10 (IL-10), in a macrophage culture. To tackle the intrinsic complexity of the network, we employed a computational modeling approach using the available literature data about specific molecular interactions. Our computational model successfully captured experimentally observed short- and long-term kinetics of key inflammatory mediators. Subsequent model analysis showed that distinct subnetworks regulate IL-10 production by impacting different temporal phases of the cAMP response element-binding protein (CREB) phosphorylation. Moreover, the model revealed that functionally similar inhibitory control circuits regulate the early and late activation phases of nuclear factor kappa B and CREB. Finally, we identified and investigated distinct signaling subnetworks that independently control the peak height and tail height of the TNF temporal trajectories. The knowledge of such subnetwork-specific regulatory effects may facilitate therapeutic interventions aimed at precise modulation of the inflammatory response. C1 [Tomaiuolo, Maurizio; Reifman, Jaques; Mitrophanov, Alexander Y.] US Army Med Res & Mat Command, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr, Dept Def Biotechnol,ATTN MCMR TT, 504 Scott St, Ft Detrick, MD USA. [Kottke, Melissa; Matheny, Ronald W., Jr.] US Army Res Inst Environm Med, Mil Performance Div, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. RP Reifman, J (reprint author), US Army Med Res & Mat Command, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr, Dept Def Biotechnol,ATTN MCMR TT, 504 Scott St, Ft Detrick, MD USA. EM jaques.reifman.civ@mail.mil FU Military Operational Medicine Research Program of U.S. Army Medical Research and Materiel Command, Fort Detrick, MD FX The authors are grateful to Dr Sridevi Nagaraja for her assistance with global sensitivity analysis and to three anonymous reviewers for their comments on an earlier version of the paper. This work was supported by the Military Operational Medicine Research Program of the U.S. Army Medical Research and Materiel Command, Fort Detrick, MD. NR 83 TC 1 Z9 1 U1 0 U2 0 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1742-206X EI 1742-2051 J9 MOL BIOSYST JI Mol. Biosyst. PY 2016 VL 12 IS 3 BP 826 EP 838 DI 10.1039/c5mb00456j PG 13 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA DF0OX UT WOS:000371039800015 PM 26751842 ER PT J AU Auysawasdi, N Chuntranuluck, S Phasomkusolsil, S Keeratinijakal, V AF Auysawasdi, Nutthanun Chuntranuluck, Sawitri Phasomkusolsil, Siriporn Keeratinijakal, Vichien TI Improving the effectiveness of three essential oils against Aedes aegypti (Linn.) and Anopheles dirus (Peyton and Harrison) SO PARASITOLOGY RESEARCH LA English DT Article DE Essential oil; Repellent; Protection time; Aedes aegypti; Anopheles dirus ID REPELLENT ACTIVITY; INSECT REPELLENTS; MOSQUITOS; LEAF; CONSTITUENTS; FORMULATION; TOXICITY; VANILLIN; DEET; L. AB Repellency of essential oil extracted from Curcuma longa, Eucalyptus globulus, and Citrus aurantium at various concentrations (5, 10, 15, 20, and 25 %) with and without 5 % vanillin was evaluated against female mosquitoes: Aedes aegypti and Anopheles dirus. The comparisons were made with a commercial chemical repellent (N,N-diethyl-3-methylbenzamide (DEET) 25 % w/w; KOR YOR 15) by arm in cage method. It was found that the essential oils with 5 % vanillin gave the longest lasting period against two mosquitoes as follows: Curcuma longa gave 150 min for Ae. aegypti, 480 min for An. dirus; Eucalyptus globulus gave 144 min for Ae. aegypti, 390 min for An. dirus; and Citrus aurantium gave 120 min for Ae. aegypti, 360 min for An. dirus. The 25 % Curcuma longa essential oil exhibited the best efficiency as equal as a commercial repellent (480 min against An. dirus). Vanillin can extend the period of time in protection against the two mosquitoes. This study indicates the potential uses of the essential oils (Curcuma longa, Eucalyptus globulus, and Citrus aurantium) with vanillin as natural mosquito repellents. C1 [Auysawasdi, Nutthanun; Chuntranuluck, Sawitri] Kasetsart Univ, Fac Agroind, Dept Biotechnol, 50 Ngam Wong Wan Rd, Bangkok 10900, Thailand. [Keeratinijakal, Vichien] Kasetsart Univ, Fac Agr, Dept Agron, 50 Ngam Wong Wan Rd, Bangkok 10900, Thailand. [Phasomkusolsil, Siriporn] Armed Forces Res Inst Med Sci, US Army Med Component, Dept Entomol, Bangkok 10400, Thailand. RP Auysawasdi, N (reprint author), Kasetsart Univ, Fac Agroind, Dept Biotechnol, 50 Ngam Wong Wan Rd, Bangkok 10900, Thailand. EM zheezelz@gmail.com NR 26 TC 3 Z9 3 U1 5 U2 20 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0932-0113 EI 1432-1955 J9 PARASITOL RES JI Parasitol. Res. PD JAN PY 2016 VL 115 IS 1 BP 99 EP 106 DI 10.1007/s00436-015-4725-3 PG 8 WC Parasitology SC Parasitology GA DE8EM UT WOS:000370868600010 PM 26358103 ER PT B AU Bottoni, CR Krul, KP AF Bottoni, Craig R. Krul, Kevin P. BE Ryu, RKN Angelo, RL Abrams, JS TI Arthroscopic Acromioclavicular Joint Repair for Acute Injury SO SHOULDERS: AANA ADVANCED ARTHROSCOPIC SURGICAL TECHNIQUES LA English DT Article; Book Chapter ID DISLOCATIONS; SEPARATIONS; MANAGEMENT; DIAGNOSIS; RELIABILITY C1 [Bottoni, Craig R.] Tripler Army Med Ctr, Sports Med, Honolulu, HI 96859 USA. [Bottoni, Craig R.] Tripler Army Med Ctr, Orthopaed Surg Serv, Residency Res, Honolulu, HI 96859 USA. [Krul, Kevin P.] Tripler Army Med Ctr, Orthopaed Surg Serv, Honolulu, HI 96859 USA. RP Bottoni, CR (reprint author), Tripler Army Med Ctr, Sports Med, Honolulu, HI 96859 USA. NR 21 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE ROAD, THOROFARE, NJ 08086-9447 USA BN 978-1-63091-002-0 PY 2016 BP 71 EP 80 PG 10 WC Surgery SC Surgery GA BE1BX UT WOS:000367697500007 ER PT B AU Warner, JJP Dilisio, MF Parada, SA AF Warner, Jon J. P. Dilisio, Matthew F. Parada, Stephen A. BE Ryu, RKN Angelo, RL Abrams, JS TI Arthroscopic Panlabral Repair SO SHOULDERS: AANA ADVANCED ARTHROSCOPIC SURGICAL TECHNIQUES LA English DT Article; Book Chapter ID ANTERIOR SHOULDER INSTABILITY; SUPERIOR LABRAL ANTERIOR; GLENOID LABRUM; CIRCUMFERENTIAL LESIONS; POSTERIOR LESIONS; AMERICAN BOARD; BANKART REPAIR; SLAP LESIONS; OUTCOMES; MANAGEMENT C1 [Warner, Jon J. P.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston Shoulder Inst, Boston, MA USA. [Dilisio, Matthew F.] Creighton Univ, Orthopaed CHI Hlth Shoulder Ctr, Orthopaed Surg, Omaha, NE 68178 USA. [Parada, Stephen A.] Eisenhower Army Med Ctr, Shoulder Surg, Ft Gordon, GA USA. [Parada, Stephen A.] Eisenhower Army Med Ctr, Ft Gordon, GA USA. [Parada, Stephen A.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Warner, JJP (reprint author), Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston Shoulder Inst, Boston, MA USA. NR 27 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE ROAD, THOROFARE, NJ 08086-9447 USA BN 978-1-63091-002-0 PY 2016 BP 285 EP 295 PG 11 WC Surgery SC Surgery GA BE1BX UT WOS:000367697500024 ER PT J AU Herbst, S AF Herbst, Seth TI Milton and Music SO ESSAYS IN CRITICISM LA English DT Article C1 [Herbst, Seth] US Mil Acad, West Point, NY 10996 USA. RP Herbst, S (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0014-0856 EI 1471-6852 J9 ESSAYS CRITICISM JI Essays Critic. PD JAN PY 2016 VL 66 IS 1 BP 96 EP 116 DI 10.1093/escrit/cgv031 PG 21 WC Literature SC Literature GA DD8FQ UT WOS:000370161300005 ER PT J AU Arcone, SA Grant, SA Boitnott, GE AF Arcone, Steven A. Grant, Steven A. Boitnott, Ginger E. TI Maxwell-Wagner Relaxation in Two Desert Soils at Medium and High Water Contents: Interpretation From Modeling of Time Domain Reflectometry Data SO IEEE JOURNAL OF SELECTED TOPICS IN APPLIED EARTH OBSERVATIONS AND REMOTE SENSING LA English DT Article DE Dielectric permittivity; electrode polarization (EP); induced polarization (IP); Maxwell-Wagner; soils ID BAND DIELECTRIC-SPECTROSCOPY; COMPLEX PERMITTIVITY; POLARIZATION AB Maxwell-Wagner relaxations (MWRs) are generally between 1 and 20 MHz in fine grain soils at volumetric water contents less than 10%. Isolated water inclusions appear to cause MWR. We used time domain reflectometry to measure complex permittivity from 6 kHz to 6 GHz of two, quartz-rich desert soils to test if MWR occur at a limited number of higher water contents because inclusion concentration should then decrease. One soil had lesser calcite; the other lesser gypsum. Water contents ranged from 6.2% to 33.8%. Unwanted electrode polarization (EP) dominates the real part of permittivity below 1 MHz. We interpreted MWR from complex refractive index models (CRIMs) that summed expressions for EP, Debye-type MWR, free water relaxation (FWR), and air volume. Broadband MWRs centered from 1 to 36 MHz exist up to 17% volumetric water contents and up to 196 MHz in the quartz-gypsum soil at saturation, with small to significant Cole-Cole factors that suggest a range of relaxation processes, and attenuation rates that increase to nearly 100 dBm(-1) as frequency increased across the 100-1000 MHz GPR bandwidth. The Cole-Cole factor generally decreased with increasing relaxation frequency, while inclusion conductivity, derived from relaxation frequency, generally increased with increasing bulk conductivity and water content. These results suggest inclusion concentration and a spectrum of their conductivity values decreased, while ionicmobility increased. At saturation, the quartz-calcite soil provided an unexpected low relaxation frequency of 1.28 MHz, possibly caused by inclusions retained within calcite growths upon quartz grains, and within minor amount of smectite. C1 [Arcone, Steven A.; Grant, Steven A.; Boitnott, Ginger E.] US Army ERDC CRREL, Hanover, NH 03755 USA. RP Arcone, SA (reprint author), US Army ERDC CRREL, Hanover, NH 03755 USA. EM Steven.A.Arcone@erdc.dren.mil FU US Army Engineer and Research Development Center 6.1 program in basic research FX This work was supported by the US Army Engineer and Research Development Center 6.1 program in basic research. NR 25 TC 0 Z9 0 U1 2 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1939-1404 EI 2151-1535 J9 IEEE J-STARS JI IEEE J. Sel. Top. Appl. Earth Observ. Remote Sens. PD JAN PY 2016 VL 9 IS 1 BP 201 EP 211 DI 10.1109/JSTARS.2015.2436822 PG 11 WC Engineering, Electrical & Electronic; Geography, Physical; Remote Sensing; Imaging Science & Photographic Technology SC Engineering; Physical Geography; Remote Sensing; Imaging Science & Photographic Technology GA DE3PE UT WOS:000370541400022 ER PT J AU Zaghi, S Holty, JEC Certal, V Abdullatif, J Guilleminault, C Powell, NB Riley, RW Camacho, M AF Zaghi, Soroush Holty, Jon-Erik C. Certal, Victor Abdullatif, Jose Guilleminault, Christian Powell, Nelson B. Riley, Robert W. Camacho, Macario TI Maxillomandibular Advancement for Treatment of Obstructive Sleep Apnea A Meta-analysis SO JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Article ID POSITIVE AIRWAY PRESSURE; MAXILLOFACIAL SURGERY; SURGICAL-TREATMENT; CONSECUTIVE PATIENTS; COMPUTED-TOMOGRAPHY; REDEFINING SUCCESS; HYOID ADVANCEMENT; ORAL APPLIANCES; MANAGEMENT; MAXILLARY AB IMPORTANCE Maxillomandibular advancement (MMA) is an invasive yet effective surgical option for obstructive sleep apnea (OSA) that achieves enlargement of the upper airway by physically expanding the facial skeletal framework. OBJECTIVE To identify criteria associated with surgical outcomes of MMA using aggregated individual patient data from multiple studies. DATA SOURCES The Cochrane Library, Scopus, Web of Science, and MEDLINE from June 1, 2014, to March 16, 2015, using the Medical Subject Heading keywords maxillomandibular advancement, orthognathic surgery, maxillary osteotomy, mandibular advancement, sleep apnea, surgical, surgery, sleep apnea syndrome, and obstructive sleep apnea. STUDY SELECTION Inclusion criteria consisted of studies in all languages of (1) adult patients who underwent MMA as treatment for OSA; (2) report of preoperative and postoperative quantitative outcomes for the apnea-hypopnea index (AHI) and/or respiratory disturbance index (RDI); and (3) report of individual patient data. Studies of patients who underwent adjunctive procedures at the time of MMA (including tonsillectomy, uvulopalatopharyngoplasty, and partial glossectomy) were excluded. DATA EXTRACTION Three coauthors systematically reviewed the articles and updated the review through March 16, 2015. The PRISMA statement was followed. Data were pooled using a random-effects model and analyzed from July 1, 2014, to September 23, 2015. MAIN OUTCOMES AND MEASURES The primary outcomes were changes in the AHI and RDI after MMA for each patient. Secondary outcomes included surgical success, defined as the percentage of patients with more than 50% reduction of the AHI to fewer than 20 events/h, and OSA cure, defined as a post-MMA AHI of fewer than 5 events/h. RESULTS Forty-five studies with individual data from 518 unique patients/interventions were included. Among patients for whom data were available, 197 of 268 (73.5%) had undergone prior surgery for OSA. Mean (SD) postoperative changes in the AHI and RDI after MMA were -47.8 (25.0) and -44.4 (33.0), respectively; mean (SE) reductions of AHI and RDI outcomes were 80.1% (1.8%) and 64.6% (4.0%), respectively; and 512 of 518 patients (98.8%) showed improvement. Significant improvements were also seen in the mean (SD) postoperative oxygen saturation nadir (70.1% [15.6%] to 87.0% [5.2%]; P < .001) and Epworth Sleepiness Scale score (13.5 [5.2] to 3.2 [3.2]; P < .001). Rates of surgical success and cure were 389 (85.5%) and 175 (38.5%), respectively, among 455 patients with AHI data and 44 (64.7%) and 13 (19.1%), respectively, among 68 patients with RDI data. Preoperative AHI of fewer than 60 events/h was the factor most strongly associated with the highest incidence of surgical cure. Nevertheless, patients with a preoperative AHI of more than 60 events/h experienced large and substantial net improvements despite modest surgical cure rates. CONCLUSIONS AND RELEVANCE Maxillomandibular advancement is an effective treatment for OSA. Most patients with high residual AHI and RDI after other unsuccessful surgical procedures for OSA are likely to benefit from MMA. C1 [Zaghi, Soroush] Univ Calif Los Angeles, David Geffen Sch Med, Dept Head & Neck Surg, 10833 LeConte Ave,Room 62-132, Los Angeles, CA 90095 USA. [Holty, Jon-Erik C.] Stanford Univ, Vet Affairs Palo Hlth Care Syst, Dept Med, Pulm Crit Care & Sleep Med Sect,Pulm Div, Palo Alto, CA 94304 USA. [Certal, Victor] Hosp CUF Porto, Dept Otorhinolaryngol, Sleep Med Ctr, Oporto, Portugal. [Certal, Victor] Univ Porto, Ctr Res Hlth Technol & Informat Syst, Rua Campo Alegre 823, P-4100 Oporto, Portugal. [Abdullatif, Jose] Hosp Bernardino Rivadavia, Dept Otorhinolaryngol, Buenos Aires, DF, Argentina. [Guilleminault, Christian; Camacho, Macario] Stanford Hosp & Clin, Dept Psychiat & Behav Sci, Sleep Med Div, Redwood City, CA USA. [Powell, Nelson B.; Riley, Robert W.] Stanford Hosp & Clin, Sleep Surg Div, Dept Otolaryngol Head & Neck Surg, Redwood City, CA USA. [Camacho, Macario] Tripler Army Med Ctr, Div Sleep Surg & Med, Dept Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA. RP Zaghi, S (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Dept Head & Neck Surg, Ctr Hlth Sci, 10833 LeConte Ave,Room 62-132, Los Angeles, CA 90095 USA. EM soroush.zaghi@gmail.com NR 68 TC 5 Z9 5 U1 2 U2 6 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6181 EI 2168-619X J9 JAMA OTOLARYNGOL JI JAMA Otolaryngol-Head Neck Surg. PD JAN PY 2016 VL 142 IS 1 BP 58 EP 66 DI 10.1001/jamaoto.2015.2678 PG 9 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA DE5RN UT WOS:000370689500010 PM 26606321 ER PT J AU Maule, AL Proctor, SP Blount, BC Chambers, DM McClean, MD AF Maule, Alexis L. Proctor, Susan P. Blount, Benjamin C. Chambers, David M. McClean, Michael D. TI Volatile Organic Compounds in Blood as Biomarkers of Exposure to JP-8 Jet Fuel Among US Air Force Personnel SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID INHALATION EXPOSURE; URINARY BIOMARKERS; DERMAL EXPOSURE; POPULATION; SMOKING; JP8 AB Objective: This study aimed to evaluate blood volatile organic compound (VOC) levels as biomarkers of occupational jet propulsion fuel 8 (JP-8) exposure while controlling for smoking. Methods: Among 69 Air Force personnel, post-shift blood samples were analyzed for components of JP-8, including ethylbenzene, toluene, o-xylene, and m/p-xylene, and for the smoking biomarker, 2,5-dimethylfuran. JP-8 exposure was characterized based on self-report and measured work shift levels of total hydrocarbons in personal air. Multivariate regression was used to evaluate the relationship between JP-8 exposure and post-shift blood VOCs while controlling for potential confounding from smoking. Results: Blood VOC concentrations were higher among US Air Force personnel who reported JP-8 exposure and work shift smoking. Breathing zone total hydrocarbons was a significant predictor of VOC blood levels, after controlling for smoking. Conclusions: These findings support the use of blood VOCs as a biomarker of occupational JP-8 exposure. C1 [Maule, Alexis L.; Proctor, Susan P.; McClean, Michael D.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Natick, MA USA. [Maule, Alexis L.; Proctor, Susan P.] US Army, Environm Med Res Inst, Div Mil Performance, 10 Gen Greene Ave,Bldg 42, Natick, MA 01760 USA. [Proctor, Susan P.] Vet Affairs Boston Healthcare Syst, Boston, MA USA. [Blount, Benjamin C.; Chambers, David M.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA. RP Maule, AL (reprint author), US Army, Environm Med Res Inst, Div Mil Performance, 10 Gen Greene Ave,Bldg 42, Natick, MA 01760 USA. EM alexis.l.maule.ctr@mail.mil FU US Army Medical Research and Materiel Command [W81XWH-06-1-0105] FX This work was supported by the US Army Medical Research and Materiel Command through a grant award (W81XWH-06-1-0105; principal investigator: SPP) to the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. NR 25 TC 0 Z9 0 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1076-2752 EI 1536-5948 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD JAN PY 2016 VL 58 IS 1 BP 24 EP 29 DI 10.1097/JOM.0000000000000611 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DD8VC UT WOS:000370204000005 PM 26716845 ER PT J AU Rinella, ME Lominadze, Z Loomba, R Charlton, M Neuschwander-Tetri, BA Caldwell, SH Kowdley, K Harrison, SA AF Rinella, Mary E. Lominadze, Zurabi Loomba, Rohit Charlton, Michael Neuschwander-Tetri, Brent A. Caldwell, Stephen H. Kowdley, Kris Harrison, Stephen A. TI Practice patterns in NAFLD and NASH: real life differs from published guidelines SO THERAPEUTIC ADVANCES IN GASTROENTEROLOGY LA English DT Article DE liver biopsy; nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; pioglitazone; practice guidelines; practice patterns; diagnosis; treatment ID FATTY LIVER-DISEASE; VITAMIN-E SUPPLEMENTATION; RANDOMIZED CONTROLLED-TRIALS; BARIATRIC SURGERY; NONALCOHOLIC STEATOHEPATITIS; HEPATOCELLULAR-CARCINOMA; CANCER PREVENTION; DIABETIC-PATIENTS; GASTRIC BYPASS; HEART-FAILURE AB Background: Management guidelines from the American Association for the Study of Liver Diseases/American College of Gastroenterology/American Gastroenterology Association published in 2012 for nonalcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) recommend weight loss, vitamin E and pioglitazone as effective therapies for the treatment of biopsy-confirmed NASH. However, little is known about how physicians in the US diagnose NASH or whether published guidelines are being followed. Methods: We assessed current diagnostic and treatment patterns of the management of NAFLD and NASH among academic gastroenterologists and hepatologists in the US using a standardized survey developed to collect information regarding respondents' practice environments, diagnostic techniques, and medication usage in patients with NAFLD/NASH. Results: We invited 482 gastroenterologists and hepatologists, predominantly from academic centers, of whom 163 completed the survey. Only 24% of providers routinely perform liver biopsy, predominantly among patients with elevated serum aminotransferases. Vitamin E is prescribed regularly by 70% while only 14% routinely prescribe pioglitazone. Despite recommendations to the contrary, similar to 25% prescribe pioglitazone or vitamin E without biopsy confirmation of NASH. Metformin is used as frequently as pioglitazone despite its proven lack of efficacy in NASH. Overall, 40-73% adhere to published guidelines, depending on the specific question. There was no significant difference seen in adherence to guidelines between gastroenterologists and hepatologists. Conclusion: This survey suggests that clinical practice patterns among gastroenterologists and hepatologists for the management of NASH frequently diverge from published practice guidelines. Although liver biopsy remains the gold standard to diagnose NASH, less than 25% of respondents routinely require it to make the diagnosis of NASH. We conclude that NASH is underdiagnosed in gastroenterology and hepatology practices, highlighting the need to refine noninvasive diagnostic tools. C1 [Rinella, Mary E.] Northwestern Univ, Feinberg Sch Med, Div Gastroenterol & Hepatol, Med, 676 N St Clair,Arkes Pavillion 14-012, Chicago, IL 60611 USA. [Lominadze, Zurabi] Northwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA. [Loomba, Rohit] Univ Calif San Diego, Div Gastroenterol & Hepatol, La Jolla, CA 92093 USA. [Charlton, Michael] Intermt Med Ctr, Salt Lake City, UT USA. [Neuschwander-Tetri, Brent A.] St Louis Univ, Div Gastroenterol & Hepatol, St Louis, MO 63103 USA. [Caldwell, Stephen H.] Univ Virginia, Gastroenterol & Hepatol, Charlottesville, VA USA. [Kowdley, Kris] Swedish Med Ctr, Med Ctr, Div Gastroenterol & Hepatol, Seattle, WA USA. [Harrison, Stephen A.] Brooke Army Med Ctr, Div Gastroenterol & Hepatol, San Antonio, TX USA. RP Rinella, ME (reprint author), Northwestern Univ, Feinberg Sch Med, Div Gastroenterol & Hepatol, Med, 676 N St Clair,Arkes Pavillion 14-012, Chicago, IL 60611 USA. EM m-rinella@northwestern.edu NR 35 TC 13 Z9 13 U1 6 U2 8 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1756-283X EI 1756-2848 J9 THER ADV GASTROENTER JI Ther. Adv. Gastroenterol. PD JAN PY 2016 VL 9 IS 1 BP 4 EP 12 DI 10.1177/1756283X15611581 PG 9 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA DE1VT UT WOS:000370415300001 PM 26770262 ER PT J AU Peterson, MS Havrylkoff, JM Grammer, PO Mickle, PF Slack, WT AF Peterson, Mark S. Havrylkoff, Jeanne-Marie Grammer, Paul O. Mickle, Paul F. Slack, William T. TI Consistent SpatioTemporal Estuarine Habitat Use during Emigration or Immigration of a Western Population of Gulf Sturgeon SO TRANSACTIONS OF THE AMERICAN FISHERIES SOCIETY LA English DT Article ID ACIPENSER-OXYRINCHUS-DESOTOI; OF-MEXICO STURGEON; SUWANNEE RIVER ESTUARY; PASCAGOULA RIVER; LIFE-HISTORY; ATLANTIC STURGEON; FLORIDA; MOVEMENT; PATTERNS; MISSISSIPPI AB The spatial and seasonal occupancy by Gulf Sturgeon Acipenser oxyrinchus desotoi was estimated using acoustically tagged fish in the Pascagoula River estuary over a 3-year period (2010-2013) and was based on 131,381 detections. Juveniles spent considerably more time in the estuary than subadults or adults, but that varied by year. Gulf Sturgeon of all size-classes entered the acoustic array earlier when stream discharge was high (2011, 2012) compared with when it was lower (2010). The difference was about 14-28 d earlier for adults and subadults but only 12-17 d for juveniles. Temporally, there were no significant differences in occupancy by year or season for adults or subadults or by year for juvenile Gulf Sturgeon, suggesting repeated patterns across the 3 years of this study. Significant and consistent spatial differences in occupancy occurred by array zone, with juveniles occupying the West zone more than the East and River zones of the acoustic array; however, occupancy in the River zone was greater than in the East zone. We found similar patterns for subadults, with the highest occupancy in the West zone compared with the East zone; use was higher in the River zone than in the East zone but there was no difference between the River and West zones. In contrast, no year, season, or zone patterns were identified for adult Gulf Sturgeon, suggesting annual movement along a defined travel corridor (from the River zone to the West zone to offshore islands), with little time spent in the estuary. Adults appear to move quickly through the system during emigration (fall) and immigration (spring) compared with longer but more variable occupancy for juveniles and subadults. Our long-term data illustrates the importance of habitat connectivity in the recovery of Gulf Sturgeon and enhances earlier work on estuarine zones used during migration periods and estuarine residency; both are important for a better understanding of critical habitat maintenance and the development of a robust recovery plan. C1 [Peterson, Mark S.; Havrylkoff, Jeanne-Marie; Grammer, Paul O.] Univ So Mississippi, Dept Coastal Sci, 703 East Beach Dr, Ocean Springs, MS 39564 USA. [Mickle, Paul F.] Mississipi Dept Marine Resources, 1141 Bayview Ave, Biloxi, MS 39530 USA. [Slack, William T.] US Army Engineer Res & Dev Ctr, Waterways Expt Stn EE A, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. RP Peterson, MS (reprint author), Univ So Mississippi, Dept Coastal Sci, 703 East Beach Dr, Ocean Springs, MS 39564 USA. EM mark.peterson@usm.edu FU National Oceanic and Atmospheric Administration Office of Protected Species [NA10NMF4720034] FX We thank M. Roberts, K. Herrington, S. Bolden, I. Baremore, and D. Rosati for technical assistance. We also thank M. Lowe, E. Satterfield, B. Ennis, S. Ashworth, E. Lang, C. Matten, J. Green, P. Vick, A. Fogg, B. Lewis, S. George, and B. J. Johnson for field and laboratory assistance. Special thanks to two external reviewers whose comments improved this manuscript. We thank the National Oceanic and Atmospheric Administration Office of Protected Species for funding (NA10NMF4720034). This research was conducted under the University of Southern Mississippi's Institute of Animal Care and Use Committee number 07081501, 09091702, and 11092209. NR 61 TC 0 Z9 0 U1 1 U2 14 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0002-8487 EI 1548-8659 J9 T AM FISH SOC JI Trans. Am. Fish. Soc. PY 2016 VL 145 IS 1 BP 27 EP 43 DI 10.1080/00028487.2015.1091382 PG 17 WC Fisheries SC Fisheries GA DE0ZP UT WOS:000370355000004 ER PT J AU Atwater, MA Darling, KA Tschopp, MA AF Atwater, Mark A. Darling, Kris A. Tschopp, Mark A. TI Solid-State Foaming by Oxide Reduction and Expansion: Tailoring the Foamed Metal Microstructure in the Cu-CuO System with Oxide Content and Annealing Conditions SO ADVANCED ENGINEERING MATERIALS LA English DT Article ID ARGON-FILLED PORES; COPPER FOAM; POROUS COPPER; SUPERPLASTIC EXPANSION; MECHANICAL-PROPERTIES; TITANIUM; FABRICATION; POROSITY; ELECTRODEPOSITION AB A new method of introducing porosity into solid metals was investigated using mixtures of Cu and CuO. The process involves distributing oxides through the Cu matrix (e.g., mechanical milling, as used here) and then reducing those oxides during annealing. The most distinguishing characteristic of this process is that pores develop within individual powder particles. In this study, we varied the oxide content (0-7 at% O), annealing temperature (400, 600, and 800 degrees C), and annealing time (up to 3 h) to investigate their effect on the foamed metal microstructure. In general, we find that the amount of porosity within the powder particles (or bulk part) can be controlled by varying of oxide content and annealing parameters. The maximum porosity of 47.4% corresponds to intermediate conditions of both temperature and oxide content (600 degrees C and approximate to 3 at% CuO, respectively). The pore size and grain size are small (<5 mu m) in comparison with other solid-state foaming techniques and are not highly sensitive to the annealing parameters used in the present study. The unique mechanisms and opportunities associated with this oxide reduction and expansion process are discussed for the Cu-CuO system as well as extensions to other metal systems. C1 [Atwater, Mark A.] Millersville Univ Pennsylvania, Dept Appl Engn Safety & Technol, Millersville, PA 17551 USA. [Atwater, Mark A.; Darling, Kris A.; Tschopp, Mark A.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Atwater, MA (reprint author), Millersville Univ Pennsylvania, Dept Appl Engn Safety & Technol, Millersville, PA 17551 USA.; Atwater, MA (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM mark.atwater@millersville.edu OI Tschopp, Mark/0000-0001-8471-5035 NR 43 TC 1 Z9 1 U1 2 U2 7 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 1438-1656 EI 1527-2648 J9 ADV ENG MATER JI Adv. Eng. Mater. PD JAN PY 2016 VL 18 IS 1 BP 83 EP 95 DI 10.1002/adem.201500063 PG 13 WC Materials Science, Multidisciplinary SC Materials Science GA DD8AL UT WOS:000370146000012 ER PT S AU Aydelotte, B Schuster, B AF Aydelotte, Brady Schuster, Brian BE Song, B Lamberson, L Casem, D Kimberley, J TI Observation and Modeling of Cone Cracks in Ceramics SO DYNAMIC BEHAVIOR OF MATERIALS, VOL 1 SE Conference Proceedings of the Society for Experimental Mechanics Series LA English DT Proceedings Paper CT Annual Conference and Exposition of the Society-for-Experimental-Mechanics on Experimental and Applied Mechanics CY JUN 08-11, 2015 CL Costa Mesa, CA SP Soc Expt Mech DE Cone crack; Impact; Indentation; Ceramic; Damage ID FRACTURE AB Ceramics undergo a complex failure process when subjected to impact by a projectile. Projectile impacts on thick ceramic targets produce varying levels of comminution, cone cracking, and radial cracking. Sphere impacts result in limited penetration and comminution relative to projectiles with a longer aspect ratio, yet significant radial and cone cracking is produced, and it is similar to Hertzian indentation. Sphere impact is a good way to study ceramics and a good validation problem to study the ability of hydrocodes to predict the formation and extent of radial and cone fractures in ceramic materials. Experimental results from normal and oblique sphere impacts on hot-pressed boron carbide cylinders are reported. Oblique sphere impacts created curved cone cracks, which did not appear oriented perpendicular to the impact surface. Cone angles appear to be the same for normal and oblique impacts for the impact conditions tested. Hydrocode predictions captured some but not all of the experimentally observed features. C1 [Aydelotte, Brady; Schuster, Brian] US Army Res Lab, RDRL WML H321 Colleran Rd, Aberdeen Proving Ground, MD 21005 USA. RP Aydelotte, B (reprint author), US Army Res Lab, RDRL WML H321 Colleran Rd, Aberdeen Proving Ground, MD 21005 USA. EM brady.b.aydelotte.civ@mail.mil NR 14 TC 0 Z9 0 U1 3 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 2191-5644 BN 978-3-319-22452-7; 978-3-319-22451-0 J9 C PROC SOC EXP MECH PY 2016 BP 19 EP 23 DI 10.1007/978-3-319-22452-7_4 PG 5 WC Mechanics; Physics, Applied SC Mechanics; Physics GA BE2OQ UT WOS:000369724800004 ER PT S AU Casem, D Huskins, E Ligda, J Schuster, B AF Casem, Daniel Huskins, Emily Ligda, Jonathan Schuster, Brian BE Song, B Lamberson, L Casem, D Kimberley, J TI A Kolsky Bar for High-Rate Micro-compression: Preliminary Results SO DYNAMIC BEHAVIOR OF MATERIALS, VOL 1 SE Conference Proceedings of the Society for Experimental Mechanics Series LA English DT Proceedings Paper CT Annual Conference and Exposition of the Society-for-Experimental-Mechanics on Experimental and Applied Mechanics CY JUN 08-11, 2015 CL Costa Mesa, CA SP Soc Expt Mech DE Split Hopkinson Pressure Bar; Kolsky Bar; High-rate testing; Interferometers; Compression testing ID DISPLACEMENT AB Initial results from a Kolsky bar with a 127 mu m diameter are presented. The small diameter is used achieve high strain-rates and for compatibility with small (tens of microns) specimens. The bar is instrumented optically; a transverse displacement interferometer is used to measure the input and reflected pulses within the input bar and a normal displacement interferometer is used to measure the transmitted pulse in the output bar. It is shown using a simple elastic impact experiment that the pulses within the bars propagate as uniaxial stress waves according the elementary theory used in the standard analysis. An example application is also given where a niobium sample is loaded at a strain rate greater than 1 M/s. C1 [Casem, Daniel] US Army Res Lab, RDRL WMP C, Aberdeen, MD 21005 USA. [Huskins, Emily] US Naval Acad, 323 Rickover Hall, Annapolis, MD 21402 USA. [Ligda, Jonathan; Schuster, Brian] US Army Res Lab, RDRL WML H, Aberdeen, MD 21005 USA. RP Casem, D (reprint author), US Army Res Lab, RDRL WMP C, Aberdeen, MD 21005 USA. EM daniel.t.casem.civ@mail.mil NR 8 TC 0 Z9 0 U1 4 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 2191-5644 BN 978-3-319-22452-7; 978-3-319-22451-0 J9 C PROC SOC EXP MECH PY 2016 BP 87 EP 92 DI 10.1007/978-3-319-22452-7_14 PG 6 WC Mechanics; Physics, Applied SC Mechanics; Physics GA BE2OQ UT WOS:000369724800014 ER PT S AU Ranade, R Heard, WF Williams, BA AF Ranade, Ravi Heard, William F. Williams, Brett A. BE Song, B Lamberson, L Casem, D Kimberley, J TI Multi-Scale Mechanical Performance of High Strength-High Ductility Concrete SO DYNAMIC BEHAVIOR OF MATERIALS, VOL 1 SE Conference Proceedings of the Society for Experimental Mechanics Series LA English DT Proceedings Paper CT Annual Conference and Exposition of the Society-for-Experimental-Mechanics on Experimental and Applied Mechanics CY JUN 08-11, 2015 CL Costa Mesa, CA SP Soc Expt Mech DE High strength-high ductility concrete; Impact resistance; High performance concrete; Micromechanics; Rate effects ID COMPOSITES; BEHAVIOR; MODEL AB A new fiber-reinforced cement-based composite, called High Strength-High Ductility Concrete (HSHDC) with unparalleled combination of compressive strength (> 150 MPa) and tensile ductility (> 3 %), has been recently developed. Due to such unique combination of properties, the specific energies of HSHDC under tension and compression at both pseudo-static and high strain rates are extremely high. The design of this engineered material is based on the fundamental principles of micromechanics which focus on the synchronous functioning of the fiber, the cementitious matrix, and their interface to achieve the desired material properties for a given structural application. For such micromechanics-based design to succeed, the material has been researched at several length scales ranging from micro-scale fiber/ matrix interactions to structural-scale impact resistance of HSHDC slabs. This paper summarizes the mechanical properties of HSHDC at various length scales to facilitate further development of this material and explore its potential for use in enhancing structural impact and blast resistance. C1 [Ranade, Ravi] SUNY Buffalo, 135 Ketter Hall, Buffalo, NY 14260 USA. [Heard, William F.; Williams, Brett A.] US Army Corps Engineers, ERDC, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. RP Ranade, R (reprint author), SUNY Buffalo, 135 Ketter Hall, Buffalo, NY 14260 USA. EM ranade@buffalo.edu RI Ranade, Ravi/I-6387-2013 OI Ranade, Ravi/0000-0001-6030-8371 NR 16 TC 0 Z9 0 U1 4 U2 8 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 2191-5644 BN 978-3-319-22452-7; 978-3-319-22451-0 J9 C PROC SOC EXP MECH PY 2016 BP 93 EP 101 DI 10.1007/978-3-319-22452-7_15 PG 9 WC Mechanics; Physics, Applied SC Mechanics; Physics GA BE2OQ UT WOS:000369724800015 ER PT S AU Meyer, CS AF Meyer, Christopher S. BE Song, B Lamberson, L Casem, D Kimberley, J TI Ballistic Perforation of Double Reinforced Concrete as a Function of Energy SO DYNAMIC BEHAVIOR OF MATERIALS, VOL 1 SE Conference Proceedings of the Society for Experimental Mechanics Series LA English DT Proceedings Paper CT Annual Conference and Exposition of the Society-for-Experimental-Mechanics on Experimental and Applied Mechanics CY JUN 08-11, 2015 CL Costa Mesa, CA SP Soc Expt Mech DE Numerical simulation; Reinforced concrete; Kinetic energy; Perforation; Residual velocity ID RIGID PROJECTILE; PENETRATION; TARGETS; OBLIQUE AB In an effort to better understand the energy required to breach double-reinforced concrete (DRC) walls it was attempted to estimate by numerical simulations the minimum kinetic energy required to perforate a DRC target. To this end, a parametric numerical study was conducted at the U.S. Army Research Laboratory. Large scale, high-fidelity, three-dimensional numerical simulations were conducted using an Eulerian shock physics code considering both eroding penetration and rigid body penetration. The parametric study investigated right cylindrical steel rods with masses of 500-2000 g and length-to-diameter ratios (L/D) of 1-10 impacting with velocities ranging from 500 to 1500 m/s, and perforating rebar reinforced concrete targets with a range of presented areas. This paper explores the numerical simulation results to consider the kinetic energy of perforation of DRC for the described range of conditions. Experimental results from the literature are compared with the numerical results. An empirical fit to the data is reported. C1 [Meyer, Christopher S.] US Army Res Lab, ATTN RDRL WML H, Aberdeen Proving Ground, MD 21005 USA. RP Meyer, CS (reprint author), US Army Res Lab, ATTN RDRL WML H, Aberdeen Proving Ground, MD 21005 USA. EM christopher.s.meyer12.civ@mail.mil NR 38 TC 0 Z9 0 U1 1 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 2191-5644 BN 978-3-319-22452-7; 978-3-319-22451-0 J9 C PROC SOC EXP MECH PY 2016 BP 205 EP 211 DI 10.1007/978-3-319-22452-7_29 PG 7 WC Mechanics; Physics, Applied SC Mechanics; Physics GA BE2OQ UT WOS:000369724800029 ER PT J AU Sethi, J Palit, R Carroll, JJ Karamian, S Saha, S Biswas, S Naik, Z Trivedi, T Litz, MS Datta, P Chattopadhyay, S Donthi, R Garg, U Jadhav, S Jain, HC Kumar, S Mehta, D Naidu, BS Bhat, GH Sheikh, JA Sihotra, S Walker, PM AF Sethi, J. Palit, R. Carroll, J. J. Karamian, S. Saha, S. Biswas, S. Naik, Z. Trivedi, T. Litz, M. S. Datta, P. Chattopadhyay, S. Donthi, R. Garg, U. Jadhav, S. Jain, H. C. Kumar, S. Mehta, D. Naidu, B. S. Bhat, G. H. Sheikh, J. A. Sihotra, S. Walker, P. M. TI Low-lying states near the I-pi=6(+) isomer in Ag-108 SO JOURNAL OF PHYSICS G-NUCLEAR AND PARTICLE PHYSICS LA English DT Article DE isomer; nuclear structure; gamma ray spectroscopy; fusion evaporation reaction ID INDUCED DEPLETION; NEUTRON-CAPTURE; GAMMA; DECAY AB The low-lying states of Ag-108 near the I-pi = 6(+) isomer have been investigated with the B-11 + Mo-100 reaction at 39 MeV beam energy. We aim at understanding the structure of the states near the isomer and identifying possible isomer depletion paths. From the gamma-gamma and gamma-gamma-gamma coincidence analysis, spectroscopy of the excited states near the isomer has been carried out to establish new transitions and modification of the previously known level scheme. The present work suggests a total of three possible transitions at energies below 500 keV from the isomer to higher excited levels, whose subsequent decay can branch to the ground state. The spins and parities of these states have been established with angular correlation and polarization measurements. The branching ratios and multipolarities of the associated gamma-rays were used in the estimation of the integral cross section for induced isomer depletion via these states. The experimental data have been compared to the results of projected Hartree-Fock calculations to understand the configurations of the levels. C1 [Sethi, J.; Palit, R.; Saha, S.; Biswas, S.; Trivedi, T.; Donthi, R.; Jadhav, S.; Jain, H. C.; Naidu, B. S.] Tata Inst Fundamental Res, Homi Bhabha Rd, Bombay 400005, Maharashtra, India. [Carroll, J. J.; Litz, M. S.] US Army Res Lab, Adelphi, MD 20783 USA. [Karamian, S.] Joint Inst Nucl Res, Dubna 141980, Russia. [Naik, Z.] Sambalpur Univ, Sambalpur 768019, India. [Datta, P.] Ananda Mohan Coll, Kolkata 700009, India. [Chattopadhyay, S.] Saha Inst Nucl Phys, Kolkata 700064, India. [Garg, U.] Univ Notre Dame, Notre Dame, IN 46556 USA. [Kumar, S.] Univ Delhi, Delhi 110007, India. [Mehta, D.; Sihotra, S.] Panjab Univ, Chandigarh 160014, India. [Bhat, G. H.; Sheikh, J. A.] Univ Kashmir, Dept Phys, Srinagar 190006, Jammu & Kashmir, India. [Walker, P. M.] Univ Surrey, Dept Phys, Guildford GU2 7XH, Surrey, England. RP Palit, R (reprint author), Tata Inst Fundamental Res, Homi Bhabha Rd, Bombay 400005, Maharashtra, India. EM palit@tifr.res.in RI Palit, Rudrajyoti/F-5185-2012 FU Department of Science and Technology, Government of India [IR/S2/PF-03/2003-II]; US National Science Foundation [PHY-1068192]; UK Science and Technology Facilities Council [ST/L005743/1] FX The authors would like to thank the members of INGA Principal Investigating Coordination Committee and INGA collaboration for making the detectors available. The staff at TIFR-BARC Pelletron-LINAC Facility is gratefully acknowledged for the smooth operation of the accelerator. J J Carroll would like to thank C J Chiara for some useful discussions. This work was partially supported by the Department of Science and Technology, Government of India under Grant No. IR/S2/PF-03/2003-II, the US National Science Foundation (Grant No. PHY-1068192), and the UK Science and Technology Facilities Council under grant No. ST/L005743/1. NR 29 TC 2 Z9 2 U1 0 U2 1 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0954-3899 EI 1361-6471 J9 J PHYS G NUCL PARTIC JI J. Phys. G-Nucl. Part. Phys. PD JAN PY 2016 VL 43 IS 1 AR 015103 DI 10.1088/0954-3899/43/1/015103 PG 15 WC Physics, Nuclear; Physics, Particles & Fields SC Physics GA DD1SV UT WOS:000369703000009 ER PT J AU Tobler, KJ Oman, S Kolp, LA AF Tobler, Kyle J. Oman, Sarah Kolp, Lisa A. TI Retained Products of Conception Associated with Intravasation of Hysterosalpingogram Contrast and Hysteroscopic Distention Media A Case Report SO JOURNAL OF REPRODUCTIVE MEDICINE LA English DT Article DE hysterosalpingography; hysteroscopic ID RESIDUAL TROPHOBLASTIC TISSUE; MANAGEMENT AB BACKGROUND: Hysteroscopic resection of retained products of conception has not been previously described to increase the risk for volume overload at the time of hysteroscopy. CASE: A 35-year-old woman with a history of recurrent pregnancy loss was evaluated by a hysterosalpingogram that identified retained products of conception with adjacent contrast intravasation. She underwent a hysteroscopic resection of the uterine septum and products of conception. During the 15-minute operating time she developed a fluid deficit of 2,300 cc of 3% sorbitol with resulting hyponatremia despite normal pressure and flow settings on the fluid management equipment. CONCLUSION: When a hysterosalpingogram demonstrates likely retained products of conception with an accompanying intravasation of contrast media, the provider should consider this finding a potential risk factor for excess intravasation of hysteroscopic distention media and take additional precautions to avoid volume overload. C1 [Tobler, Kyle J.; Oman, Sarah; Kolp, Lisa A.] Johns Hopkins Univ, Sch Med, Dept Gynecol & Obstet, Div Reprod Endocrinol & Infertil, Baltimore, MD 21205 USA. RP Tobler, KJ (reprint author), Womack Army Med Ctr, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, 2817 Reilly Rd, Ft Bragg, NC 28307 USA. EM kyle.tobler@gmail.com NR 8 TC 0 Z9 0 U1 0 U2 0 PU SCI PRINTERS & PUBL INC PI ST LOUIS PA PO DRAWER 12425 8342 OLIVE BLVD, ST LOUIS, MO 63132 USA SN 0024-7758 EI 1943-3565 J9 J REPROD MED JI J. Reprod. Med. PD JAN-FEB PY 2016 VL 61 IS 1-2 BP 69 EP 72 PG 4 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA DD7PL UT WOS:000370116500013 PM 26995892 ER PT J AU Zhao, WJ Elias, AL Rajukumar, LP Kim, HI O'Brien, DJ Zimmerman, BK Penev, ES Terrones, M Yakobson, BI Wei, BQ Lu, XL Suhr, J AF Zhao, Wenjie Elias, Ana L. Rajukumar, Lakshmy P. Kim, Hyung-Ick O'Brien, Daniel J. Zimmerman, Brandon K. Penev, Evgeni S. Terrones, Mauricio Yakobson, Boris I. Wei, Bingqing Lu, X. Lucas Suhr, Jonghwan TI Controllable and Predictable Viscoelastic Behavior of 3D Boron-Doped Multiwalled Carbon Nanotube Sponges SO PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION LA English DT Article ID COMPOSITES; RECOVERY; AEROGELS; CREEP AB 3D carbon nanotube (CNT)-based macrostructures are the subject of extensive attention because the outstanding properties of 1D and 2D nanostructures have not been fully translated into key engineering applications. Generation of 3D CNT architectures with covalent junctions could endow the new materials with extraordinary mechanical properties. In this study, detailed experimental characterization and statistical comparison are carried out on 3D boron-doped multiwalled CNT (CBxMWNT) sponges with covalent junctions and undoped multiwalled CNT (undoped-MWNT) sponges without junctions. By investigating the plastic, elastic, viscoelastic, and dynamic viscoelastic properties of both sponges, as well as the dependency of these mechanical properties on material morphology, the CBxMWNT sponge is found to be a more predictable and stable material than the undoped-MWNT sponge. Statistical comparison proves that the excellent properties of the CBxMWNT are attributed to its "elbow-like" junctions inside the 3D networks, which prevent permanent buckling and bundling of the CNTs under extreme loading. Thus, by optimizing the covalent junctions in 3D CNT sponges, their functional behavior can be controlled and regulated. These findings may promote applications of 3D CNT sponges in various fields, including biomedical or high-precision devices in which lightweight, controllable, and reliable mechanical properties are always desirable. C1 [Zhao, Wenjie; Zimmerman, Brandon K.; Wei, Bingqing; Lu, X. Lucas] Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. [Elias, Ana L.; Terrones, Mauricio] Penn State Univ, Dept Phys, 104 Davey Lab, University Pk, PA 16802 USA. [Elias, Ana L.; Terrones, Mauricio] Penn State Univ, Ctr Dimens & Layered Mat 2, 104 Davey Lab, University Pk, PA 16802 USA. [Rajukumar, Lakshmy P.; Terrones, Mauricio] Penn State Univ, Dept Mat Sci & Engn, 104 Davey Lab, University Pk, PA 16802 USA. [Kim, Hyung-Ick] Korea Inst Ind Technol, Reg Adv Mfg Technol Agcy, Jinju 660805, South Korea. [O'Brien, Daniel J.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Penev, Evgeni S.; Yakobson, Boris I.] Rice Univ, Dept Mat Sci & NanoEngn, Houston, TX 77005 USA. [Terrones, Mauricio] Shinshu Univ, Res Ctr Exot Nanocarbons JST, Wakasato 4-17-1, Nagano 3808553, Japan. [Suhr, Jonghwan] Sungkyunkwan Univ, Dept Energy Sci, Dept Polymer Sci & Engn, 300 Chunchun Dong, Suwon 440746, South Korea. RP Lu, XL (reprint author), Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA.; Suhr, J (reprint author), Sungkyunkwan Univ, Dept Energy Sci, Dept Polymer Sci & Engn, 300 Chunchun Dong, Suwon 440746, South Korea. EM xlu@udel.edu; suhr@skku.edu RI Wei, Bingqing/A-4525-2008 OI Wei, Bingqing/0000-0002-9416-1731 FU U.S. Air Force Office of Scientific Research MURI Grant [FA9550-12-1-0035]; National Research Foundation of Korea [2014R1A2A2A01005496] FX This work was supported by the U.S. Air Force Office of Scientific Research MURI Grant (FA9550-12-1-0035) entitled "Synthesis and Characterization of 3D Carbon Nanotube Solid Networks." J.S. also would like to thank the financial support from the National Research Foundation of Korea (2014R1A2A2A01005496). NR 32 TC 0 Z9 0 U1 11 U2 27 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 0934-0866 EI 1521-4117 J9 PART PART SYST CHAR JI Part. Part. Syst. Charact. PD JAN PY 2016 VL 33 IS 1 BP 21 EP 26 DI 10.1002/ppsc.201500136 PG 6 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA DD8ON UT WOS:000370186600004 ER PT J AU Patel, JS Boddu, VM Brenner, MW Kumar, A AF Patel, Jignesh S. Boddu, Veera M. Brenner, Matthew W. Kumar, Ashok TI Effect of fabric structure and polymer matrix on flexural strength, interlaminar shear stress, and energy dissipation of glass fiber-reinforced polymer composites SO TEXTILE RESEARCH JOURNAL LA English DT Article DE glass fiber-reinforced polymer; flexural strength; interlaminar shear stress; energy dissipation; scanning electron microscope failure analysis ID WEAVE; BEHAVIOR AB We report the effect of glass fiber structure and the epoxy polymer system on the flexural strength, interlaminar shear stress (ILSS), and energy absorption properties of glass fiber-reinforced polymer (GFRP) composites. Four different GFRP composites were fabricated from two glass fiber textiles of different fabric count and strand density and two resin systems, a cycloaliphatic and a linear aliphatic system. These composites were fabricated using the vacuum-assisted resin transfer method. The flexural stress and ILSS data were obtained using a three-point bending test following ASTM 790-10 and ASTM D2344/D2344M standards. The GFRP composite sheet fabricated using a larger fabric count showed weak flexural strength as well as poor ILSS properties. However, it showed an average increase in energy dissipation of 95% and 7%, for resins SC780 and SC15, respectively, after five compression cycles over the measured range of compression strain. In comparison with the SC15 resin, the SC780 resin proved to have better flexural and ILSS properties but decreased energy dissipation. The results of this investigation help with the design of textile-reinforced composites for applications where bending strength, ILSS, and energy absorption are important. C1 [Patel, Jignesh S.; Boddu, Veera M.; Brenner, Matthew W.; Kumar, Ashok] US Army, Engineer Res & Dev Ctr, Construct Engn Res Lab, POB 9005, Champaign, IL 61826 USA. RP Boddu, VM (reprint author), US Army, Engineer Res & Dev Ctr, Construct Engn Res Lab, POB 9005, Champaign, IL 61826 USA. EM veera.boddu@usace.army.mil FU Oak Ridge Institute for Science and Education (ORISE) [DE-AC05-06OR23100] FX Mr. Jignesh S. Patel and Dr. Matthew W. Brenner were supported by an Oak Ridge Institute for Science and Education (ORISE) postdoctoral fellowship under contract number DE-AC05-06OR23100 between US Army ERDC and the US Department of Energy. NR 23 TC 0 Z9 0 U1 7 U2 8 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0040-5175 EI 1746-7748 J9 TEXT RES J JI Text. Res. J. PD JAN PY 2016 VL 86 IS 2 BP 127 EP 137 DI 10.1177/0040517515586165 PG 11 WC Materials Science, Textiles SC Materials Science GA DD5WS UT WOS:000369996000002 ER PT J AU Bell, TM Bunton, TE Shaia, CI Raymond, JW Honnold, SP Donnelly, GC Shamblin, JD Wilkinson, ER Cashman, KA AF Bell, T. M. Bunton, T. E. Shaia, C. I. Raymond, J. W. Honnold, S. P. Donnelly, G. C. Shamblin, J. D. Wilkinson, E. R. Cashman, K. A. TI Pathogenesis of Bolivian Hemorrhagic Fever in Guinea Pigs SO VETERINARY PATHOLOGY LA English DT Article DE aerosols; models; animal; arenaviruses; New World; Bolivia; viral hemorrhagic fever; American; Cavia porcellus; Machupo virus ID MACHUPO VIRUS-INFECTION; EPIDEMIOLOGY; ARENAVIRUSES; MANAGEMENT; PATHOLOGY; ANIMALS; WILD AB Machupo virus, the cause of Bolivian hemorrhagic fever, is a highly lethal viral hemorrhagic fever with no Food and Drug Administration-approved vaccines or therapeutics. This study evaluated the guinea pig as a model using the Machupo virus-Chicava strain administered via aerosol challenge. Guinea pigs (Cavia porcellus) were serially sampled to evaluate the temporal progression of infection, gross and histologic lesions, and sequential changes in serum chemistry and hematology. The incubation period was 5 to 12 days, and complete blood counts revealed leukopenia with lymphopenia and thrombocytopenia. Gross pathologic findings included congestion and hemorrhage of the gastrointestinal mucosa and serosa, noncollapsing lungs with fluid exudation, enlarged lymph nodes, and progressive pallor and friability of the liver. Histologic lesions consisted of foci of degeneration and cell death in the haired skin, liver, pancreas, adrenal glands, lymph nodes, tongue, esophagus, salivary glands, renal pelvis, small intestine, and large intestine. Lymphohistiocytic interstitial pneumonia was also present. Inflammation within the central nervous system, interpreted as nonsuppurative encephalitis, was histologically apparent approximately 16 days postexposure and was generally progressive. Macrophages in the tracheobronchial lymph node, on day 5 postexposure, were the first cells to demonstrate visible viral antigen. Viral antigen was detected throughout the lymphoid system by day 9 postexposure, followed by prominent spread within epithelial tissues and then brain. This study provides insight into the course of Machupo virus infection and supports the utility of guinea pigs as an additional animal model for vaccine and therapeutic development. C1 [Bell, T. M.; Bunton, T. E.; Shaia, C. I.; Raymond, J. W.; Honnold, S. P.; Donnelly, G. C.; Shamblin, J. D.; Wilkinson, E. R.; Cashman, K. A.] US Army, Med Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA. [Bunton, T. E.] Eicarte LLC, Gettysburg, PA USA. [Shaia, C. I.] Joint Pathol Ctr, Silver Spring, MD USA. RP Bell, TM (reprint author), US Army, Med Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA. EM todd.m.bell.mil@mail.mil FU US Army Medical Research Institute of Infectious Diseases [195743]; Defense Threat Reduction Agency, Joint Science and Technology Office / Translational Medical Technologies grant [TMTI_0045_09_RD_T] FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The research was performed under US Army Medical Research Institute of Infectious Diseases project No. 195743 and funded by a Defense Threat Reduction Agency, Joint Science and Technology Office / Translational Medical Technologies grant (TMTI_0045_09_RD_T). NR 30 TC 3 Z9 3 U1 2 U2 6 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0300-9858 EI 1544-2217 J9 VET PATHOL JI Vet. Pathol. PD JAN PY 2016 VL 53 IS 1 BP 190 EP 199 DI 10.1177/0300985815588609 PG 10 WC Pathology; Veterinary Sciences SC Pathology; Veterinary Sciences GA DD0SM UT WOS:000369629800019 PM 26139838 ER PT J AU Garcia, RA Tennent, DJ Chang, D Wenke, JC Sanchez, CJ AF Garcia, Rebecca A. Tennent, David J. Chang, David Wenke, Joseph C. Sanchez, Carlos J., Jr. TI An In Vitro Comparison of PMMA and Calcium Sulfate as Carriers for the Local Delivery of Gallium(III) Nitrate to Staphylococcal Infected Surgical Sites SO BIOMED RESEARCH INTERNATIONAL LA English DT Article ID ANTIMICROBIAL RELEASE KINETICS; ACRYLIC BONE-CEMENT; BIOFILM FORMATION; POLYMETHYLMETHACRYLATE BEADS; ACINETOBACTER-BAUMANNII; ANTIBACTERIAL THERAPY; ORTHOPEDIC INFECTIONS; REVISION SURGERY; IRON CHELATORS; MECHANISMS AB Antibiotic-loaded bone cements, including poly(methyl methacrylate) (PMMA) and calcium sulfate (CaSO4), are often used for treatment of orthopaedic infections involving Staphylococcus spp., although the effectiveness of this treatment modality may be limited due to the emergence of antimicrobial resistance and/or the development of biofilms within surgical sites. Gallium(III) is an iron analog capable of inhibiting essential iron-dependent pathways, exerting broad antimicrobial activity against multiple microorganisms, including Staphylococcus spp. Herein, we evaluated PMMA and CaSO4 as carriers for delivery of gallium(III) nitrate (Ga(NO3)(3)) to infected surgical sites by assessing the release kinetics subsequent to incorporation and antimicrobial activity against S. aureus and S. epidermidis. PMMA and to a lesser extentCaSO(4) were observed to be compatible as carriers for Ga(NO3)(3), eluting concentrations with antimicrobial activity against planktonic bacteria, inhibiting bacterial growth, and preventing bacterial colonization of beads, and effective against established bacterial biofilms of S. aureus and S. epidermidis. Collectively, our in vitro results indicate that PMMA is a more suitable carrier compared to CaSO4 for delivery of Ga(NO3)(3); moreover they provide evidence for the potential use of Ga(NO3)(3) with PMMA as a strategy for the prevention and/or treatment for orthopaedic infections. C1 [Garcia, Rebecca A.; Tennent, David J.; Chang, David; Wenke, Joseph C.; Sanchez, Carlos J., Jr.] US Army Inst Surg Res, Extrem Trauma & Regenerat Med, JBSA Ft Sam, Houston, TX USA. RP Sanchez, CJ (reprint author), US Army Inst Surg Res, Extrem Trauma & Regenerat Med, JBSA Ft Sam, Houston, TX USA. EM sanchezcj@livemail.uthscsa.edu FU Combat Casualty Research Program, Medical Research and Materiel Command FX This work was supported by intramural funding from the Combat Casualty Research Program, Medical Research and Materiel Command. NR 55 TC 1 Z9 1 U1 3 U2 6 PU HINDAWI LTD PI LONDON PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, WIT 5HE, ENGLAND SN 2314-6133 EI 2314-6141 J9 BIOMED RES INT JI Biomed Res. Int. PY 2016 AR 7078989 DI 10.1155/2016/7078989 PG 11 WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental SC Biotechnology & Applied Microbiology; Research & Experimental Medicine GA DC5LJ UT WOS:000369262200001 ER PT J AU White, RF Steele, L O'Callaghan, JP Sullivan, K Binns, JH Golomb, BA Bloom, FE Bunker, JA Crawford, F Graves, JC Hardie, A Klimas, N Knox, M Meggs, WJ Melling, J Philbert, MA Grashow, R AF White, Roberta F. Steele, Lea O'Callaghan, James P. Sullivan, Kimberly Binns, James H. Golomb, Beatrice A. Bloom, Floyd E. Bunker, James A. Crawford, Fiona Graves, Joel C. Hardie, Anthony Klimas, Nancy Knox, Marguerite Meggs, William J. Melling, Jack Philbert, Martin A. Grashow, Rachel TI Recent research on Gulf War illness and other health problems in veterans of the 1991 Gulf War: Effects of toxicant exposures during deployment SO CORTEX LA English DT Review DE Gulf War illness; Pesticide; Organophosphates; Sarin; Cyclosarin; Veterans' health ID POSTTRAUMATIC-STRESS-DISORDER; CHRONIC MULTISYMPTOM ILLNESS; BLOOD-BRAIN-BARRIER; NEURALLY-MEDIATED HYPOTENSION; POPULATION-BASED-SAMPLE; SELF-REPORTED SYMPTOMS; US ARMY VETERANS; PERSIAN-GULF; PYRIDOSTIGMINE BROMIDE; RISK-FACTORS AB Veterans of Operation Desert Storm/Desert Shield - the 1991 Gulf War (GW) - are a unique population who returned from theater with multiple health complaints and disorders. Studies in the U.S. and elsewhere have consistently concluded that approximately 25-32% of this population suffers from a disorder characterized by symptoms that vary somewhat among individuals and include fatigue, headaches, cognitive dysfunction, musculoskeletal pain, and respiratory, gastrointestinal and dermatologic complaints. Gulf War illness (GWI) is the term used to describe this disorder. In addition, brain cancer occurs at increased rates in subgroups of GW veterans, as do neuropsychological and brain imaging abnormalities. Chemical exposures have become the focus of etiologic GWI research because nervous system symptoms are prominent and many neurotoxicants were present in theater, including organophosphates (OPs), carbamates, and other pesticides; sarin/cyclosarin nerve agents, and pyridostigmine bromide (PB) medications used as prophylaxis against chemical warfare attacks. Psychiatric etiologies have been ruled out. This paper reviews the recent literature on the health of 1991 GW veterans, focusing particularly on the central nervous system and on effects of toxicant exposures. In addition, it emphasizes research published since 2008, following on an exhaustive review that was published in that year that summarizes the prior literature (RACGWI, 2008). We conclude that exposure to pesticides and/or to PB are causally associated with GWI and the neurological dysfunction in GW veterans. Exposure to sarin and cyclosarin and to oil well fire emissions are also associated with neurologically based health effects, though their contribution to development of the disorder known as GWI is less clear. Gene environment interactions are likely to have contributed to development of GWI in deployed veterans. The health consequences of chemical exposures in the GW and other conflicts have been called "toxic wounds" by veterans. This type of injury requires further study and concentrated treatment research efforts that may also benefit other occupational groups with similar exposure-related illnesses. (C) 2015 The Authors. Published by Elsevier Ltd. C1 [White, Roberta F.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA. [Steele, Lea] Baylor Univ, Inst Biomed Studies, Waco, TX 76798 USA. [O'Callaghan, James P.] NIOSH, Mol Neurotoxicol Toxicol & Mol Biol Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, MS 3014, Morgantown, WV USA. [Sullivan, Kimberly] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA. [Binns, James H.] Res Advisory Comm Gulf War Vet Illnesses, Phoenix, AZ USA. [Golomb, Beatrice A.] Univ Calif San Diego, La Jolla, CA 92093 USA. [Bloom, Floyd E.] Scripps Res Inst, Mol & Integrat Neurosci Dept, La Jolla, CA 92037 USA. [Bunker, James A.] Natl Gulf War Resource Ctr, Topeka, KS USA. [Crawford, Fiona] Roskamp Inst, TBI Res Program, Sarasota, FL USA. [Graves, Joel C.] US Army, Crestview, FL USA. [Hardie, Anthony] Vet Common Sense, Bradenton, FL USA. [Klimas, Nancy] Nova SE Univ, Inst Neuroimmune Med, Miami, FL USA. [Knox, Marguerite] McEntire Joint Natl Guard Base, Eastover, SC USA. [Meggs, William J.] E Carolina Univ, Sch Med, Brody Sch Med, Dept Emergency Med, 3ED311, Greenville, NC USA. [Melling, Jack] US Govt Accountabil Off, Salisbury, Wilts, England. [Philbert, Martin A.] Univ Michigan, Sch Publ Hlth, Ann Arbor, MI 48109 USA. [Grashow, Rachel] Northeastern Univ, Dept Civil & Environm Engn, Boston, MA 02115 USA. RP White, RF (reprint author), Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA. EM rwhite@bu.edu; Lea_Steele@baylor.edu; jdo5@cdc.gov; tty@bu.edu; Binns.Jim@gmail.com; bgolomb@popmail.ucsd.edu; fbloom@bloomsciassocs.net; desert-storm1991@outlook.com; fcrawford@RFDN.ORG; joelcgraves@gmail.com; anthony.d.hardie@gmail.com; nklimas@nova.edu; marguerite.l.knox.mil@mail.mil; meggsw@ecu.edu; jmelling@ptd.net; Philbert@umich.edu; r.grashow@neu.edu OI Sullivan, Kimberly/0000-0001-7940-6123 FU Intramural CDC HHS [CC999999] NR 158 TC 9 Z9 9 U1 10 U2 23 PU ELSEVIER MASSON PI MILANO PA VIA PALEOCAPA 7, 20121 MILANO, ITALY SN 0010-9452 EI 1973-8102 J9 CORTEX JI Cortex PD JAN PY 2016 VL 74 BP 449 EP 475 DI 10.1016/j.cortex.2015.08.022 PG 27 WC Behavioral Sciences; Neurosciences SC Behavioral Sciences; Neurosciences & Neurology GA DC8GS UT WOS:000369458500045 PM 26493934 ER PT J AU Sabatini, JJ Oyler, KD AF Sabatini, Jesse J. Oyler, Karl D. TI Recent Advances in the Synthesis of High Explosive Materials SO CRYSTALS LA English DT Review DE energetic materials; explosives; synthesis; organic chemistry; processing ID LEAD-FREE REPLACEMENT; ENERGETIC MATERIALS; SENSITIVITY; DECOMPOSITION; PERFORMANCE; KINETICS; DBX-1; POWER AB This review discusses the recent advances in the syntheses of high explosive energetic materials. Syntheses of some relevant modern primary explosives and secondary high explosives, and the sensitivities and properties of these molecules are provided. In addition to the synthesis of such materials, processing improvement and formulating aspects using these ingredients, where applicable, are discussed in detail. C1 [Sabatini, Jesse J.] US Army, Res Lab, Weapons & Mat Res Directorate WMRD Lethal Div, Energet Technol Branch, Aberdeen Proving Ground, MD 21005 USA. [Oyler, Karl D.] US Army, Armaments Res Dev & Engn Ctr, Energet Warheads & Mfg Directorate, Explos Dev Branch, Picatinny Arsenal, NJ 07806 USA. RP Sabatini, JJ (reprint author), US Army, Res Lab, Weapons & Mat Res Directorate WMRD Lethal Div, Energet Technol Branch, Aberdeen Proving Ground, MD 21005 USA.; Oyler, KD (reprint author), US Army, Armaments Res Dev & Engn Ctr, Energet Warheads & Mfg Directorate, Explos Dev Branch, Picatinny Arsenal, NJ 07806 USA. EM jesse.j.sabatini.civ@mail.mil; karl.d.oyler.civ@mail.mil FU US Army Research Laboratory (ARL); Armaments Research, Development & Engineering Center (ARDEC); Research, Development & Engineering Command (RDECOM); Ordnance Environmental Program (OEP) FX The authors are indebted to Brian D. Roos (ARL) and Noah Lieb (Hughes Associates, Inc.) for many insightful discussions pertaining to this review. Thomas M. Klapotke is gratefully acknowledged for his invitation in submitting this article. The authors thank the US Army Research Laboratory (ARL), the Armaments Research, Development & Engineering Center (ARDEC), the Research, Development & Engineering Command (RDECOM) and the Ordnance Environmental Program (OEP) for funding of this work. NR 53 TC 8 Z9 8 U1 12 U2 33 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2073-4352 J9 CRYSTALS JI Crystals PD JAN PY 2016 VL 6 IS 1 AR 5 DI 10.3390/cryst6010005 PG 22 WC Crystallography; Materials Science, Multidisciplinary SC Crystallography; Materials Science GA DC9AH UT WOS:000369512000004 ER PT J AU Lamberson, L Eliasson, V Weerasooriya, T AF Lamberson, L. Eliasson, V. Weerasooriya, T. TI Quantitative Visualization of Dynamic Material Behavior SO EXPERIMENTAL MECHANICS LA English DT Editorial Material C1 [Lamberson, L.] Drexel Univ, Dept Mech Engn & Mech, 3141 Chestnut St, Philadelphia, PA 19104 USA. [Eliasson, V.] Univ So Calif, Dept Aerosp & Mech Engn, 854 Downey Way, Los Angeles, CA 90089 USA. [Weerasooriya, T.] Army Res Lab, Soldier Protect Sci Branch, Aberdeen Proving Ground, MD 21005 USA. RP Lamberson, L (reprint author), Drexel Univ, Dept Mech Engn & Mech, 3141 Chestnut St, Philadelphia, PA 19104 USA. EM les@drexel.edu NR 0 TC 0 Z9 0 U1 2 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0014-4851 EI 1741-2765 J9 EXP MECH JI Exp. Mech. PD JAN PY 2016 VL 56 IS 1 SI SI BP 1 EP 2 DI 10.1007/s11340-015-0118-x PG 2 WC Materials Science, Multidisciplinary; Mechanics; Materials Science, Characterization & Testing SC Materials Science; Mechanics GA DC6JN UT WOS:000369326200001 ER PT J AU Sanborn, B Gunnarsson, CA Foster, M Weerasooriya, T AF Sanborn, B. Gunnarsson, C. A. Foster, M. Weerasooriya, T. TI Quantitative Visualization of Human Cortical Bone Mechanical Response: Studies on the Anisotropic Compressive Response and Fracture Behavior as a Function of Loading Rate SO EXPERIMENTAL MECHANICS LA English DT Article DE Cortical bone; Image correlation; Fracture toughness; Failure criteria ID SPLIT HOPKINSON BAR; CRACK-GROWTH-RESISTANCE; COMPACT-BONE; DYNAMIC FRACTURE; TOUGHNESS; FAILURE; MICROCRACKING; STIFFNESS; TISSUE; AGE AB Blast and impact events regularly cause damage to human tissues. Efforts to improve protective gear are made through numerical simulation of these events where human tissues are exposed to high-rate loading conditions. Accurate simulation results can only be obtained if constitutive models are used that are based on precisely carried out experimental studies. Experimental studies on bone are challenging because of the relatively brittle nature of bone as well as the importance of the bone being in a hydrated state prior to experiments to avoid changing the mechanical properties. Past studies have utilized strain gages which require a period of drying time to bond strain gages to the surface of the bone. In this study, rate dependent fracture and compressive responses of wet human femur bone are investigated with in situ quantitative visualization. The fracture properties of cortical bone are studied transverse to the longitudinal axis of the bone up to high stress intensity factor rates, and the rate dependent compressive response is investigated in both longitudinal and transverse directions. The rate dependent nature of the fracture response, and the compressive behavior of human cortical bone over a range of rates from 0.001-1000 s-1 is discussed with the aid of quantitative visualization. C1 [Sanborn, B.; Foster, M.] US Army, Res Lab, ORISE, Aberdeen, MD USA. [Gunnarsson, C. A.; Weerasooriya, T.] Army Res Lab, Aberdeen, MD USA. RP Weerasooriya, T (reprint author), Army Res Lab, Aberdeen, MD USA. EM Brett.sanborn2.ctr@mail.mil; tusit.weerasooriya.civ@mail.mil NR 41 TC 0 Z9 0 U1 2 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0014-4851 EI 1741-2765 J9 EXP MECH JI Exp. Mech. PD JAN PY 2016 VL 56 IS 1 SI SI BP 81 EP 95 DI 10.1007/s11340-015-0060-y PG 15 WC Materials Science, Multidisciplinary; Mechanics; Materials Science, Characterization & Testing SC Materials Science; Mechanics GA DC6JN UT WOS:000369326200007 ER PT J AU Morris, CL Brown, EN Agee, C Bernert, T Bourke, MAM Burkett, MW Buttler, WT Byler, DD Chen, CF Clarke, AJ Cooley, JC Gibbs, PJ Imhoff, SD Jones, R Kwiatkowski, K Mariam, FG Merrill, FE Murray, MM Olinger, CT Oro, DM Nedrow, P Saunders, A Terrones, G Trouw, F Tupa, D Vogan, W Winkler, B Wang, Z Zellner, MB AF Morris, C. L. Brown, E. N. Agee, C. Bernert, T. Bourke, M. A. M. Burkett, M. W. Buttler, W. T. Byler, D. D. Chen, C. F. Clarke, A. J. Cooley, J. C. Gibbs, P. J. Imhoff, S. D. Jones, R. Kwiatkowski, K. Mariam, F. G. Merrill, F. E. Murray, M. M. Olinger, C. T. Oro, D. M. Nedrow, P. Saunders, A. Terrones, G. Trouw, F. Tupa, D. Vogan, W. Winkler, B. Wang, Z. Zellner, M. B. TI New Developments in Proton Radiography at the Los Alamos Neutron Science Center (LANSCE) SO EXPERIMENTAL MECHANICS LA English DT Article DE Proton radiography; Dynamic materials; Static applications; Tomography; Detonation propagation; Richtmyer-Meshov instability; Metal jets; Casting; Fuel rods; Chelyabinsk; Meteorite ID COMBUSTION SYNTHESIS; X-RAY; ACCELERATOR; FACILITY; TA5SI3; TI5SI3 AB An application of nuclear physics, a facility for using protons for flash radiography, has been developed at the Los Alamos Neutron Science Center (LANSCE). Protons have proven far superior to high energy x-rays for flash radiography because of their long mean free path, good position resolution, and low scatter background. Although this facility is primarily used for studying very fast phenomena such as high explosive driven experiments, it is finding increasing application to other fields, such as tomography of static objects, phase changes in materials and the dynamics of chemical reactions. The advantages of protons are discussed, data from some recent experiments will be reviewed and concepts for new techniques are introduced. C1 [Morris, C. L.; Brown, E. N.; Bourke, M. A. M.; Burkett, M. W.; Buttler, W. T.; Byler, D. D.; Chen, C. F.; Clarke, A. J.; Cooley, J. C.; Gibbs, P. J.; Imhoff, S. D.; Kwiatkowski, K.; Mariam, F. G.; Merrill, F. E.; Murray, M. M.; Olinger, C. T.; Oro, D. M.; Nedrow, P.; Saunders, A.; Terrones, G.; Trouw, F.; Tupa, D.; Vogan, W.; Wang, Z.] Los Alamos Natl Lab, Los Alamos, NM 87544 USA. [Agee, C.; Jones, R.] Univ New Mexico, Albuquerque, NM 87131 USA. [Bernert, T.; Winkler, B.] Goethe Univ Frankfurt, Inst Geowissensch, Abt Kristallog, Altenhoferallee 1, D-60438 Frankfurt, Germany. [Zellner, M. B.] US Army, Res Lab, RDRL WMP D, Aberdeen, MD 21005 USA. RP Morris, CL (reprint author), Los Alamos Natl Lab, Los Alamos, NM 87544 USA. EM cmorris@lanl.gov OI Brown, Eric/0000-0002-6812-7820; Morris, Christopher/0000-0003-2141-0255; Tupa, Dale/0000-0002-6265-5016 FU U.S. Department of Energy (DOE) through LANL/LDRD Program [DE-AC5206NA25396]; U.S. DOE, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering FX This work was performed under the auspices of the U.S. Department of Energy under Contract DE-AC5206NA25396. This work benefited from important contributions from the LANSCE pRad team and accelerator staff. We gratefully acknowledge the support of the U.S. Department of Energy (DOE) through the LANL/LDRD Program for this work. A. J. C., S. D. I., P. J. G. and the casting mold filling experiment were supported by A. J. C.'s Early Career award from the U.S. DOE, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering. NR 44 TC 1 Z9 1 U1 3 U2 8 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0014-4851 EI 1741-2765 J9 EXP MECH JI Exp. Mech. PD JAN PY 2016 VL 56 IS 1 SI SI BP 111 EP 120 DI 10.1007/s11340-015-0077-2 PG 10 WC Materials Science, Multidisciplinary; Mechanics; Materials Science, Characterization & Testing SC Materials Science; Mechanics GA DC6JN UT WOS:000369326200009 ER PT J AU Warnell, G David, P Chellappa, R AF Warnell, Garrett David, Philip Chellappa, Rama TI Ray Saliency: Bottom-Up Visual Saliency for a Rotating and Zooming Camera SO INTERNATIONAL JOURNAL OF COMPUTER VISION LA English DT Article DE Visual saliency; Pan-tilt-zoom camera ID BINARY SEARCH TREES; SELF-CALIBRATION; ATTENTION; FEATURES AB We extend the classical notion of computational visual saliency to multi-image data collected using a stationary pan-tilt-zoom (PTZ) camera by introducing the concept of consistency: the requirement that the set of generated saliency maps should each assign the same saliency value to unique regions of the environment that appear in more than one image. We show that processing each image independently will often fail to provide a consistent measure of saliency, and that using an image mosaic to quantify saliency suffers from several drawbacks. We then propose ray saliency and an immediate extension, approximate ray saliency: a mosaic-free method for calculating a consistent measure of bottom-up saliency. Experimental results demonstrating the effectiveness of the proposed approach are presented. C1 [Warnell, Garrett; David, Philip] US Army, Res Lab, Adelphi, MD USA. [Chellappa, Rama] Univ Maryland, College Pk, MD 20742 USA. RP Warnell, G (reprint author), US Army, Res Lab, Adelphi, MD USA. EM garrett.a.warnell.civ@mail.mil FU U.S. Army Research Office (ARO) MURI Grant [W911NF-09-1-0383] FX Funding for this work was provided by U.S. Army Research Office (ARO) MURI Grant W911NF-09-1-0383. NR 39 TC 0 Z9 0 U1 4 U2 7 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0920-5691 EI 1573-1405 J9 INT J COMPUT VISION JI Int. J. Comput. Vis. PD JAN PY 2016 VL 116 IS 2 BP 174 EP 189 DI 10.1007/s11263-015-0842-9 PG 16 WC Computer Science, Artificial Intelligence SC Computer Science GA DC7TJ UT WOS:000369423000004 ER PT J AU Hennigar, SR McClung, JP AF Hennigar, Stephen R. McClung, James P. TI Homeostatic regulation of trace mineral transport by ubiquitination of membrane transporters SO NUTRITION REVIEWS LA English DT Review DE iron transport; ubiquitination; zinc transport; ZIP14 ID METAL-ION TRANSPORTER; EHLERS-DANLOS-SYNDROME; ZRT1 ZINC TRANSPORTER; SUBCELLULAR-LOCALIZATION; IRON UPTAKE; ACRODERMATITIS-ENTEROPATHICA; BIOCHEMICAL BASIS; LIV-1 SUBFAMILY; BREAST-CANCER; BOUND IRON AB Post-translational modification is a critical mechanism by which trace mineral transporters rapidly adapt to their environment to homeostatically regulate ion transport. Recently, a novel pathway was described whereby iron stimulates the ubiquitination and proteasomal degradation of the trace mineral transporter ZIP14. Discovery of this pathway suggests the proteasome as a potential therapeutic target for regulation of iron storage. Moreover, these findings contribute to a theoretical framework that can be applied to other ubiquitinated trace mineral transporters. This review will detail the current state of knowledge regarding the ubiquitination of trace mineral transporters, focusing on iron and zinc transporters, and the potential utility of post-translational modification of trace mineral transporters in the treatment of disease. C1 [Hennigar, Stephen R.; McClung, James P.] US Army, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. RP McClung, JP (reprint author), US Army, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. EM james.p.mcclung8.civ@mail.mil FU US Army Military Research and Material Command FX The authors thank Drs Phil Karl, Erin Gaffney-Stomberg, and Andrew Young for critical review of the manuscript. This manuscript was supported in part by the US Army Military Research and Material Command and appointment to the US Army Research Institute of Environmental Medicine administered by the Oak Ridge Institute for Science and Education (to S.R.H.) through an interagency agreement between the US Department of Energy and the US Army Medical Research and Material Command. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the US Army or the US Department of Defense. Any citations or commercial organizations and trade names in this report do not constitute an official Department of the Army endorsement of approval of the products or services of these organizations. NR 63 TC 4 Z9 4 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0029-6643 EI 1753-4887 J9 NUTR REV JI Nutr. Rev. PD JAN PY 2016 VL 74 IS 1 BP 59 EP 67 DI 10.1093/nutrit/nuv060 PG 9 WC Nutrition & Dietetics SC Nutrition & Dietetics GA DC9JQ UT WOS:000369538100005 PM 26611242 ER PT J AU Polyak, CS Yuhas, K Singa, B Khaemba, M Walson, J Richardson, BA John-Stewart, G AF Polyak, Christina S. Yuhas, Krista Singa, Benson Khaemba, Monica Walson, Judd Richardson, Barbra A. John-Stewart, Grace TI Cotrimoxazole Prophylaxis Discontinuation among Antiretroviral-Treated HIV-1-Infected Adults in Kenya: A Randomized Non-inferiority Trial SO PLOS MEDICINE LA English DT Article ID HIV-INFECTED ADULTS; PNEUMOCYSTIS-CARINII-PNEUMONIA; OPPORTUNISTIC INFECTIONS; TRIMETHOPRIM-SULFAMETHOXAZOLE; COTE-DIVOIRE; FOLLOW-UP; THERAPY; MORTALITY; MORBIDITY; MALARIA AB Background Cotrimoxazole (CTX) prophylaxis is recommended by the World Health Organization (WHO) for HIV-1-infected individuals in settings with high infectious disease prevalence. The WHO 2006 guidelines were developed prior to the scale-up of antiretroviral therapy (ART). The threshold for CTX discontinuation following ART is undefined in resource-limited settings. Methods and Findings Between 1 February 2012 and 30 September 2013, we conducted an unblinded non-inferiority randomized controlled trial of CTX prophylaxis cessation versus continuation among HIV-1-infected adults on ART for >= 18 mo with CD4 count >350 cells/mm(3) in a malaria-endemic region in Kenya. Participants were randomized and followed up at 3-mo intervals for 12 mo. The primary endpoint was a composite of morbidity (malaria, pneumonia, and diarrhea) and mortality. Incidence rate ratios (IRRs) were estimated using Poisson regression. Among 538 ART-treated adults screened, 500 were enrolled and randomized, 250 per arm. Median age was 40 y, 361 (72%) were women, and 442 (88%) reported insecticide-treated bednet use. Combined morbidity/mortality was significantly higher in the CTX discontinuation arm (IRR = 2.27, 95% CI 1.52-3.38; p < 0.001), driven by malaria morbidity. There were 34 cases of malaria, with 33 in the CTX discontinuation arm (IRR = 33.02, 95% CI 4.52-241.02; p = 0.001). Diarrhea and pneumonia rates did not differ significantly between arms (IRR = 1.36, 95% CI 0.82-2.27, and IRR = 1.43, 95% CI 0.54-3.75, respectively). Study limitations include a lack of placebo and a lower incidence of morbidity events than expected. Conclusions CTX discontinuation among ART-treated, immune-reconstituted adults in a malaria-endemic region resulted in increased incidence of malaria but not pneumonia or diarrhea. Malaria endemicity may be the most relevant factor to consider in the decision to stop CTX after ART-induced immune reconstitution in regions with high infectious disease prevalence. These data support the 2014 WHO CTX guidelines. C1 [Polyak, Christina S.] Walter Reed Army Inst Res, US Mil, HIV Res Program, Bethesda, MD USA. [Polyak, Christina S.; Walson, Judd; Richardson, Barbra A.; John-Stewart, Grace] Univ Washington, Dept Med, Seattle, WA USA. [Yuhas, Krista; Walson, Judd; Richardson, Barbra A.; John-Stewart, Grace] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA. [Singa, Benson; Khaemba, Monica] Kenya Govt Med Res Ctr, Nairobi, Kenya. [Walson, Judd; John-Stewart, Grace] Univ Washington, Dept Pediat, Seattle, WA 98195 USA. [Richardson, Barbra A.] Univ Washington, Dept Biostat, Seattle, WA 98195 USA. [John-Stewart, Grace] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA. RP Polyak, CS (reprint author), Walter Reed Army Inst Res, US Mil, HIV Res Program, Bethesda, MD USA.; Polyak, CS (reprint author), Univ Washington, Dept Med, Seattle, WA USA. EM cpolyak@hivresearch.org FU Merle A. Sande Award in International Infectious Diseases, Infectious Disease Society of America (IDSA); Armed Forces Health Surveillance Center - Department of Defense Global Emerging Infections System; NIAID of the National Institutes of Health; NCI of the National Institutes of Health; NIMH of the National Institutes of Health; NIDA of the National Institutes of Health; NICHD of the National Institutes of Health; NHLBI of the National Institutes of Health; NIA of the National Institutes of Health; NIGMS of the National Institutes of Health; NIDDK of the National Institutes of Health [P30AI027757]; NICHD [K24-HD054314] FX Supported by the Merle A. Sande Award in International Infectious Diseases, Infectious Disease Society of America (IDSA) (http://www.idsociety.org/Index.aspx) and the Armed Forces Health Surveillance Center - Department of Defense Global Emerging Infections System (http://www.afhsc.mil/Home/Divisions/GEIS). Research reported in this publication was also supported by NIAID, NCI, NIMH, NIDA, NICHD, NHLBI, NIA, NIGMS, NIDDK of the National Institutes of Health (www.nih.gov) under award number P30AI027757 and NICHD K24-HD054314 (GJS). Vestergaard Frandsen (http://www.vestergaard.com/) donated insecticide treated bednets and water filters. Alere Inc. (http://www.alere.com/ww/en.html) donated CD4 cartridges for Pima machines. The views expressed are those of the authors and should not be construed to represent the positions of the U.S. Army or the Department of Defense. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 29 TC 5 Z9 5 U1 0 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1549-1676 J9 PLOS MED JI PLos Med. PD JAN PY 2016 VL 13 IS 1 AR e1001934 DI 10.1371/journal.pmed.1001934 PG 16 WC Medicine, General & Internal SC General & Internal Medicine GA DC7AL UT WOS:000369370600003 PM 26731191 ER PT J AU Nykaza, JR Ye, YS Nelson, RL Jackson, AC Beyer, FL Davis, EM Page, K Sharick, S Winey, KI Elabd, YA AF Nykaza, Jacob R. Ye, Yuesheng Nelson, Rachel L. Jackson, Aaron C. Beyer, Frederick L. Davis, Eric M. Page, Kirt Sharick, Sharon Winey, Karen I. Elabd, Yossef A. TI Polymerized ionic liquid diblock copolymers: impact of water/ion clustering on ion conductivity SO SOFT MATTER LA English DT Article ID ANION-EXCHANGE MEMBRANES; FUEL-CELL APPLICATIONS; ELECTROLYTE MEMBRANES; PROTON CONDUCTIVITY; BLOCK-COPOLYMERS; NAFION; MORPHOLOGY; TRANSPORT; ENHANCEMENT; IONOMER AB Herein, we examine the synergistic impact of both ion clustering and block copolymer morphology on ion conductivity in two polymerized ionic liquid (PIL) diblock copolymers with similar chemistries but different side alkyl spacer chain lengths (ethyl versus undecyl). When saturated in liquid water, water/ion clusters were observed only in the PIL block copolymer with longer alkyl side chains (undecyl) as evidenced by both small-angle neutron scattering and intermediate-angle X-ray scattering, i.e., water/ion clusters form within the PIL microdomain under these conditions. The resulting bromide ion conductivity in the undecyl sample was higher than the ethyl sample (14.0 mS cm(-1) versus 6.1 mS cm(-1) at 50 degrees C in liquid water) even though both samples had the same block copolymer morphology (lamellar) and the undecyl sample had a lower ion exchange capacity (0.9 meq g(-1) versus 1.4 meq g(-1)). No water/ion clusters were observed in either sample under high humidity or dry conditions. The resulting ion conductivity in the undecyl sample with lamellar morphology was significantly higher in the liquid water saturated state compared to the high humidity state (14.0 mS cm(-1) versus 4.2 mS cm(-1)), whereas there was no difference in ion conductivity in the ethyl sample when comparing these two states. These results show that small chemical changes to ion-containing block copolymers can induce water/ion clusters within block copolymer microdomains and this can subsequently have a significant effect on ion transport. C1 [Nykaza, Jacob R.; Ye, Yuesheng; Nelson, Rachel L.] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. [Jackson, Aaron C.; Beyer, Frederick L.] Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Davis, Eric M.] Clemson Univ, Dept Chem & Biomol Engn, Clemson, SC 29634 USA. [Page, Kirt] NIST, Mat Sci & Engn Div, Gaithersburg, MD 20899 USA. [Sharick, Sharon; Winey, Karen I.] Univ Penn, Dept Mat Sci & Engn, 3231 Walnut St, Philadelphia, PA 19104 USA. [Elabd, Yossef A.] Texas A&M Univ, Dept Chem Engn, College Stn, TX 77845 USA. RP Elabd, YA (reprint author), Texas A&M Univ, Dept Chem Engn, College Stn, TX 77845 USA. EM elabd@tamu.edu RI Elabd, Yossef/G-9866-2014 OI Elabd, Yossef/0000-0002-7790-9445 FU U.S. Army Research Office [W911NF-14-0310, W911NF-07-1-0452, W911NF-13-1-0363]; Nanotechnology Institute [NTI 1001-037]; National Research Council (NRC) Research Associateship Program (RAP); USARL FX The research at Drexel University and Texas A&M University was supported in part by the U.S. Army Research Office under grant no. W911NF-14-0310, W911NF-07-1-0452 and the Nanotechnology Institute under grant no. NTI 1001-037. The research at NIST was supported in part by the National Research Council (NRC) Research Associateship Program (RAP). The research at USARL was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARL. The research at the University of Pennsylvania was supported in part by the U.S. Army Research Office under grant no. W911NF-13-1-0363. NR 44 TC 6 Z9 6 U1 10 U2 42 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1744-683X EI 1744-6848 J9 SOFT MATTER JI Soft Matter PY 2016 VL 12 IS 4 BP 1133 EP 1144 DI 10.1039/c5sm02053k PG 12 WC Chemistry, Physical; Materials Science, Multidisciplinary; Physics, Multidisciplinary; Polymer Science SC Chemistry; Materials Science; Physics; Polymer Science GA DD2JF UT WOS:000369747900017 PM 26575014 ER PT J AU Lim, RB AF Lim, Robert B. TI Comment on: Comprehensive evaluation of the effect of bariatric surgery on pelvic floor disorders SO SURGERY FOR OBESITY AND RELATED DISEASES LA English DT Editorial Material C1 [Lim, Robert B.] Tripler Army Med Ctr, Honolulu, HI USA. RP Lim, RB (reprint author), Tripler Army Med Ctr, Honolulu, HI USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1550-7289 EI 1878-7533 J9 SURG OBES RELAT DIS JI Surg. Obes. Relat. Dis. PD JAN PY 2016 VL 12 IS 1 BP 143 EP 143 PG 1 WC Surgery SC Surgery GA DC8JY UT WOS:000369466900020 PM 26433643 ER PT J AU Ippolito, DL AbdulHameed, MDM Tawa, GJ Baer, CE Permenter, MG McDyre, BC Dennis, WE Boyle, MH Hobbs, CA Streicker, MA Snowden, BS Lewis, JA Wallqvist, A Stallings, JD AF Ippolito, Danielle L. AbdulHameed, Mohamed Diwan M. Tawa, Gregory J. Baer, Christine E. Permenter, Matthew G. McDyre, Bonna C. Dennis, William E. Boyle, Molly H. Hobbs, Cheryl A. Streicker, Michael A. Snowden, Bobbi S. Lewis, John A. Wallqvist, Anders Stallings, Jonathan D. TI Gene Expression Patterns Associated With Histopathology in Toxic Liver Fibrosis SO TOXICOLOGICAL SCIENCES LA English DT Article DE toxic liver injury; transcriptomics; bioinformatics; fibrosis; biomarkers; histopathology ID HEPATIC STELLATE CELLS; DIBENZO-P-DIOXINS; CARBON-TETRACHLORIDE; SUBCHRONIC/CHRONIC TOXICITY; GROWTH-FACTOR; 1,2,3,4,6,7,8-HEPTACHLORODIBENZO-P-DIOXIN HPCDD; CIRRHOTIC LIVER; LUNG FIBROSIS; MOUSE MODEL; SHORT-TERM AB Toxic industrial chemicals induce liver injury, which is difficult to diagnose without invasive procedures. Identifying indicators of end organ injury can complement exposure-based assays and improve predictive power. A multiplexed approach was used to experimentally evaluate a panel of 67 genes predicted to be associated with the fibrosis pathology by computationally mining DrugMatrix, a publicly available repository of gene microarray data. Five-day oral gavage studies in male Sprague Dawley rats dosed with varying concentrations of 3 fibrogenic compounds (allyl alcohol, carbon tetrachloride, and 4,4'-methylenedianiline) and 2 nonfibrogenic compounds (bromobenzene and dexamethasone) were conducted. Fibrosis was definitively diagnosed by histopathology. The 67-plex gene panel accurately diagnosed fibrosis in both microarray and multiplexed-gene expression assays. Necrosis and inflammatory infiltration were comorbid with fibrosis. ANOVA with contrasts identified that 51 of the 67 predicted genes were significantly associated with the fibrosis phenotype, with 24 of these specific to fibrosis alone. The protein product of the gene most strongly correlated with the fibrosis phenotype PCOLCE (Procollagen C-Endopeptidase Enhancer) was dose-dependently elevated in plasma from animals administered fibrogenic chemicals (P < .05). Semiquantitative global mass spectrometry analysis of the plasma identified an additional 5 protein products of the gene panel which increased after fibrogenic toxicant administration: fibronectin, ceruloplasmin, vitronectin, insulin-like growth factor binding protein, and alpha 2-macroglobulin. These results support the data mining approach for identifying gene and/or protein panels for assessing liver injury and may suggest bridging biomarkers for molecular mediators linked to histopathology. C1 [Ippolito, Danielle L.; Dennis, William E.; Lewis, John A.; Stallings, Jonathan D.] USACEHR, Environm Hlth Program, Ft Detrick, MD 21702 USA. [AbdulHameed, Mohamed Diwan M.; Tawa, Gregory J.; Wallqvist, Anders] US Army, Dept Def, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr,Med Res & Mat Comma, Ft Detrick, MD 21702 USA. [Baer, Christine E.; Permenter, Matthew G.] Excet Inc, Frederick, MD 21702 USA. [McDyre, Bonna C.] Oak Ridge Inst Sci & Educ, Frederick, MD 21702 USA. [Boyle, Molly H.; Hobbs, Cheryl A.; Streicker, Michael A.] Integrated Syst Lab, Res Triangle Pk, NC 27709 USA. [Snowden, Bobbi S.] Univ Maryland, Sch Publ Hlth, Maryland Inst Appl Environm Hlth, College Pk, MD 20742 USA. [Tawa, Gregory J.] NIH, Translat Med Div, Bldg 10, Bethesda, MD 20892 USA. RP Ippolito, DL (reprint author), US Army, Biomarkers Program, Ctr Environm Hlth Res, 568 Doughten Dr, Ft Detrick, MD 21702 USA. EM Danielle.L.Ippolito2.civ@mail.mil FU Military Operational Medicine Research Program; U.S. Army's Network Science Initiative, U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland; U.S. Department of Energy; U.S. Army Medical Research and Materiel Command FX The work was supported by the Military Operational Medicine Research Program and the U.S. Army's Network Science Initiative, U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland. This work was also supported in part by an appointment at U.S. Army Center for Environmental Health Research administered by Oak Ridge Institute for Science and Education through an interagency agreement between U.S. Department of Energy and U.S. Army Medical Research and Materiel Command [B.C.M.]. NR 128 TC 3 Z9 3 U1 4 U2 5 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD JAN PY 2016 VL 149 IS 1 BP 67 EP 88 DI 10.1093/toxsci/kfv214 PG 22 WC Toxicology SC Toxicology GA DC5BA UT WOS:000369233900007 PM 26396155 ER PT J AU Martins, KAO Cooper, CL Stronsky, SM Norris, SLW Kwilas, SA Steffens, JT Benko, JG van Tongeren, SA Bavari, S AF Martins, Karen A. O. Cooper, Christopher L. Stronsky, Sabrina M. Norris, Sarah L. W. Kwilas, Steven A. Steffens, Jesse T. Benko, Jacqueline G. van Tongeren, Sean A. Bavari, Sina TI Adjuvant-enhanced CD4 T Cell Responses are Critical to Durable Vaccine Immunity SO EBIOMEDICINE LA English DT Article DE Vaccine; Adjuvant; Durable protection; Immune correlates; Ebola virus ID VIRUS-LIKE PARTICLES; (HPV)-16/18 AS04-ADJUVANTED VACCINE; PROTECTS NONHUMAN-PRIMATES; HEPATITIS-B-VACCINE; EBOLA-VIRUS; LETHAL EBOLA; DENDRITIC CELLS; HPV-6/11/16/18 VACCINE; RENAL-INSUFFICIENCY; TARGETED VACCINE AB Protein-based vaccines offer a safer alternative to live-attenuated or inactivated vaccines but have limited immunogenicity. The identification of adjuvants that augment immunogenicity, specifically in a manner that is durable and antigen-specific, is therefore critical for advanced development. In this study, we use the filovirus virus-like particle (VLP) as a model protein-based vaccine in order to evaluate the impact of four candidate vaccine adjuvants on enhancing long term protection from Ebola virus challenge. Adjuvants tested include poly-ICLC (Hiltonol), MPLA, CpG 2395, and alhydrogel. We compared and contrasted antibody responses, neutralizing antibody responses, effector T cell responses, and T follicular helper (Tfh) cell frequencies with each adjuvant's impact on durable protection. We demonstrate that in this system, the most effective adjuvant elicits a Th1-skewed antibody response and strong CD4 T cell responses, including an increase in Tfh frequency. Using immune-deficient animals and adoptive transfer of serum and cells from vaccinated animals into naive animals, we further demonstrate that serum and CD4 T cells play a critical role in conferring protection within effective vaccination regimens. These studies inform on the requirements of long term immune protection, which can potentially be used to guide screening of clinical-grade adjuvants for vaccine clinical development. (C) 2015 The Authors. Published by Elsevier B.V. C1 [Martins, Karen A. O.; Cooper, Christopher L.; Stronsky, Sabrina M.; Steffens, Jesse T.; Benko, Jacqueline G.; van Tongeren, Sean A.; Bavari, Sina] US Army Med Res Inst Infect Dis, Mol & Translat Sci, 1425 Porter St, Ft Detrick, MD 21702 USA. [Kwilas, Steven A.] US Army Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA. [Norris, Sarah L. W.] US Army Med Res Inst Infect Dis, Res Support Div, 1425 Porter St, Ft Detrick, MD 21702 USA. RP Bavari, S (reprint author), US Army Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM sina.bavari.civ@mail.mil OI Stronsky, Sabrina/0000-0001-5964-3156 NR 87 TC 2 Z9 2 U1 1 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 2352-3964 J9 EBIOMEDICINE JI EBioMedicine PD JAN PY 2016 VL 3 BP 67 EP 78 DI 10.1016/j.ebiom.2015.11.041 PG 12 WC Medicine, General & Internal SC General & Internal Medicine GA DC1ZA UT WOS:000369015800014 PM 26870818 ER PT J AU Gibson, AM Cohen, GW Boyce, KK Houston, MN Bacon, CEW AF Gibson, Amy M. Cohen, Gary W. Boyce, Kelly K. Houston, Megan N. Bacon, Cailee E. Welch TI Personal and Environmental Characteristics Associated With Burnout in Athletic Trainers: A Critically Appraised Topic SO INTERNATIONAL JOURNAL OF ATHLETIC THERAPY & TRAINING LA English DT Article AB Clinical Question: What personal and environmental characteristics are associated with burnout in athletic trainers, as measured by the Maslach Burnout Inventory (MBI) and Athletic Training Burnout Inventory (ATBI)? Clinical Bottom Line: There is strong evidence suggesting that personal and environmental factors are associated with burnout in athletic trainers, as measured by the MBI and ATBI. While it is difficult to identify a single contributing factor that increases the athletic trainer's perception of burnout, athletic trainers should be aware of the characteristics associated with the condition and take appropriate action to reduce the risk of burnout. C1 [Gibson, Amy M.; Cohen, Gary W.; Boyce, Kelly K.; Bacon, Cailee E. Welch] AT Still Univ, Athlet Training Program, Mesa, AZ 85206 USA. [Houston, Megan N.] Keller Army Hosp, West Point, NY 10996 USA. RP Gibson, AM (reprint author), AT Still Univ, Athlet Training Program, Mesa, AZ 85206 USA. NR 12 TC 0 Z9 0 U1 1 U2 1 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 2157-7277 EI 2157-7285 J9 INT J ATHL THER TRAI JI Int. J. Athl. Ther. Train. PD JAN PY 2016 VL 21 IS 1 BP 5 EP 13 DI 10.1123/ijatt.2015-0017 PG 9 WC Sport Sciences SC Sport Sciences GA DC3VJ UT WOS:000369146700002 ER PT J AU Schyman, P Liu, RF Wallqvist, A AF Schyman, Patric Liu, Ruifeng Wallqvist, Anders TI General Purpose 2D and 3D Similarity Approach to Identify hERG Blockers SO JOURNAL OF CHEMICAL INFORMATION AND MODELING LA English DT Article ID K+ CHANNEL; POTASSIUM CHANNELS; CARDIAC-ARRHYTHMIA; QSAR MODELS; DE-POINTES; I-KR; CLASSIFICATION; BLOCKADE; INHIBITION; PREDICTION AB Screening compounds for human ether-a-go-go-related gene (hERG) channel inhibition is an important component of early stage drug development and assessment. In this study, we developed a high-confidence (p-value < 0.01) hERG prediction model based on a combined two-dimensional (2D) and three-dimensional (3D) modeling approach. We developed a 3D similarity conformation approach (SCA) based on examining a limited fixed number of pairwise 3D similarity scores between a query molecule and a set of known hERG blockers. By combining 3D SCA with 2D similarity ensemble approach (SEA) methods, we achieved a maximum sensitivity in hERG inhibition prediction with an accuracy not achieved by either method separately. The combined model achieved 69% sensitivity and 95% specificity on an independent external data set. Further validation showed that the model correctly picked up documented hERG inhibition or interactions among the Food and Drug Administration- approved drugs with the highest similarity scores with 18 of 20 correctly identified. The combination of ascertaining 2D and 3D similarity of compounds allowed us to synergistically use 2D fingerprint matching with 3D shape and chemical complementarity matching. C1 [Schyman, Patric; Liu, Ruifeng; Wallqvist, Anders] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, DoD Biotechnol High Performance Comp Software App, 2405 Whittier Dr, Frederick, MD 21702 USA. RP Schyman, P; Wallqvist, A (reprint author), US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, DoD Biotechnol High Performance Comp Software App, 2405 Whittier Dr, Frederick, MD 21702 USA. EM pschyman@bhsai.org; sven.a.wallqvist.civ@mail.mil RI Schyman, Patric/F-1810-2011 FU U.S. Army Medical Research and Materiel Command; Defense Threat Reduction Agency [CBCall14-CBS-05-2-0007] FX The authors were supported by the U.S. Army Medical Research and Materiel Command (Ft. Detrick, MD) and the Defense Threat Reduction Agency grant CBCall14-CBS-05-2-0007. High-performance computing resources were made available by the U.S. Department of Defense High Performance Computing Modernization Program. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or of the U.S. Department of Defense. This paper has been approved for public release with unlimited distribution. NR 52 TC 1 Z9 1 U1 2 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1549-9596 EI 1549-960X J9 J CHEM INF MODEL JI J. Chem Inf. Model. PD JAN PY 2016 VL 56 IS 1 BP 213 EP 222 DI 10.1021/acs.jcim.5b00616 PG 10 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Computer Science, Information Systems; Computer Science, Interdisciplinary Applications SC Pharmacology & Pharmacy; Chemistry; Computer Science GA DB9VA UT WOS:000368864600019 PM 26718126 ER PT J AU Koontz, JM Kumsher, DM Kelly, R Stallings, JD AF Koontz, Jason M. Kumsher, David M. Kelly, Richard, III Stallings, Jonathan D. TI Effect of 2 Bedding Materials on Ammonia Levels in Individually Ventilated Cages SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE LA English DT Article ID WELFARE; HEALTH; MICE AB This study sought to identify an optimal rodent bedding and cage-change interval to establish standard procedures for the IVC in our rodent vivarium. Disposable cages were prefilled with either corncob or alpha-cellulose bedding and were used to house 2 adult Sprague Dawley rats (experimental condition) or contained no animals (control). Rats were observed and intracage ammonia levels measured daily for 21 d. Intracage ammonia accumulation became significant by day 8 in experimental cages containing alpha-cellulose bedding, whereas experimental cages containing corncob bedding did not reach detectable levels of ammonia until day 14. In all 3 experimental cages containing alpha-cellulose, ammonia exceeded 100 ppm (our maximum acceptable limit) by day 11. Two experimental corncob cages required changing at days 16 and 17, whereas the remaining cage containing corncob bedding lasted the entire 21 d without reaching the 100-ppm ammonia threshold. These data suggests that corncob bedding provides nearly twice the service life of alpha-cellulose bedding in the IVC system. C1 [Koontz, Jason M.; Stallings, Jonathan D.] US Army, Ctr Environm Hlth Res, Ft Detrick, MD USA. [Kumsher, David M.] Excet, Ft Detrick, MD USA. [Kelly, Richard, III] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Koontz, JM (reprint author), US Army, Ctr Environm Hlth Res, Ft Detrick, MD USA. EM jason.m.koontz6.civ@mail.mil NR 14 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1559-6109 J9 J AM ASSOC LAB ANIM JI J. Amer. Assoc. Lab. Anim. Sci. PD JAN PY 2016 VL 55 IS 1 BP 25 EP 28 PG 4 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA DC2JT UT WOS:000369043700007 PM 26817976 ER PT J AU Takhampunya, R Tippayachai, B Korkusol, A Promsathaporn, S Leepitakrat, S Sinwat, W Schuster, AL Richards, AL AF Takhampunya, Ratree Tippayachai, Bousaraporn Korkusol, Achareeya Promsathaporn, Sommai Leepitakrat, Surachai Sinwat, Warattaya Schuster, Anthony L. Richards, Allen L. TI Transovarial Transmission of Co-Existing Orientia tsutsugamushi Genotypes in Laboratory-Reared Leptotrombidium imphalum SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Transovarial transmission; Co-existing genotypes; Orientia tsutsugamushi; Leptotrombidium imphalum; Scrub typhus ID POLYMERASE-CHAIN-REACTION; ELECTRON-MICROSCOPIC OBSERVATIONS; RICKETTSIA-TSUTSUGAMUSHI; SCRUB TYPHUS; VERTICAL TRANSMISSION; TROMBICULIDAE; ACARI; PALLIDUM; CHIGGERS; IDENTIFICATION AB The co-evolution of Orientia tsutsugamushi and its vector/host Leptotrombidium mites is important for this bacterium to survive and exist in its environment. The data in this study demonstrated that O. tsutsugamushi has adapted to take advantage of the parasitic nature of the host's larval stage and thus increase its chance of transmission to a vertebrate host and potentially to other vector mites by increasing its density at the time of transmission. Our data demonstrated that during the larval stage the density of O. tsutsugamushi was at its highest level compared to other life stages (Kruskal-Wallis, p<0.0001). We further revealed that the different O. tsutsugamushi 56-kDa type-specific antigen (TSA) genotypes within the mite were maintained and preserved during transovarial transmission from the Leptotrombidium imphalum, lines Li-3 and Li-5. No sequence difference of 56-kDa TSA gene (variable domain I-III, 765bp) was observed between the UT302-like genotype found in mothers and their offspring (100% identity). However, one or two nonsynonymous mutations in the 56-kDa TSA gene were observed in the Karp-like genotypes found in the F1 offspring with a percent difference ranging from 0.13 to 0.26 for nucleotide sequences and from 0.39 to 0.78 for amino acid sequences. Additionally, the composition of co-existing O. tsutsugamushi genotypes was maintained in L. imphalum lines through transsovarial and transstadial transmission processes; however, the proportion of these genotypes in each stage varied (larva, nymph, adult). These results show some of the key characteristics of O. tsutsugamushi maintenance within and transmission among its vector/host L. imphalum. C1 [Takhampunya, Ratree; Tippayachai, Bousaraporn; Korkusol, Achareeya; Promsathaporn, Sommai; Leepitakrat, Surachai; Sinwat, Warattaya; Schuster, Anthony L.] US Army Med Component Armed Forces Res Inst Med S, Dept Entomol, Bangkok, Thailand. [Richards, Allen L.] Naval Med Res Ctr, Viral & Rickettsial Dis Dept, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. RP Richards, AL (reprint author), Naval Med Res Ctr, Viral & Rickettsial Dis Dept, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM allen.l.richards.civ@mail.mil FU DoD MIDRP program [6000.RAD1.WJ.A0310] FX We are grateful for Mr. Taweesak Monkanna and Mr. Opas Thachinin managing the mite colony and in providing mite specimens for this study. This work was supported by the DoD MIDRP program work unit # 6000.RAD1.WJ.A0310. NR 22 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 EI 1557-7759 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD JAN 1 PY 2016 VL 16 IS 1 BP 33 EP 41 DI 10.1089/vbz.2014.1753 PG 9 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA DB6EJ UT WOS:000368606000006 PM 26771218 ER PT J AU Dretsch, MN Williams, K Emmerich, T Crynen, G Ait-Ghezala, G Chaytow, H Mathura, V Crawford, FC Iverson, GL AF Dretsch, Michael N. Williams, Kathy Emmerich, Tanja Crynen, Gogce Ait-Ghezala, Ghania Chaytow, Helena Mathura, Venkat Crawford, Fiona C. Iverson, Grant L. TI Brain-derived neurotropic factor polymorphisms, traumatic stress, mild traumatic brain injury, and combat exposure contribute to postdeployment traumatic stress SO BRAIN AND BEHAVIOR LA English DT Article DE BDNF; deployment; genetics; military; posttraumatic stress disorder; psychological health; traumatic brain injury ID DOPAMINE-RECEPTOR GENE; ALZHEIMERS-DISEASE; DRD2 GENE; BINDING CHARACTERISTICS; HEALTHY-VOLUNTEERS; COGNITIVE RESERVE; APOE GENOTYPE; USE DISORDERS; ALCOHOL-USE; A1 ALLELE AB Background In addition to experiencing traumatic events while deployed in a combat environment, there are other factors that contribute to the development of posttraumatic stress disorder (PTSD) in military service members. This study explored the contribution of genetics, childhood environment, prior trauma, psychological, cognitive, and deployment factors to the development of traumatic stress following deployment. Methods Both pre- and postdeployment data on 231 of 458 soldiers were analyzed. Postdeployment assessments occurred within 30days from returning stateside and included a battery of psychological health, medical history, and demographic questionnaires; neurocognitive tests; and blood serum for the D2 dopamine receptor (DRD2), apolipoprotein E (APOE), and brain-derived neurotropic factor (BDNF) genes. Results Soldiers who screened positive for traumatic stress at postdeployment had significantly higher scores in depression (d=1.91), anxiety (d=1.61), poor sleep quality (d=0.92), postconcussion symptoms (d=2.21), alcohol use (d=0.63), traumatic life events (d=0.42), and combat exposure (d=0.91). BDNF Val66 Met genotype was significantly associated with risk for sustaining a mild traumatic brain injury (mTBI) and screening positive for traumatic stress. Predeployment traumatic stress, greater combat exposure and sustaining an mTBI while deployed, and the BDNF Met/Met genotype accounted for 22% of the variance of postdeployment PTSD scores (R-2=0.22, P<0.001). However, predeployment traumatic stress, alone, accounted for 17% of the postdeployment PTSD scores. Conclusion These findings suggest predeployment traumatic stress, genetic, and environmental factors have unique contributions to the development of combat-related traumatic stress in military service members. C1 [Dretsch, Michael N.] US Army, Aeromed Res Lab, 6901 Farrel Rd, Ft Rucker, AL USA. [Dretsch, Michael N.; Williams, Kathy] Walter Reed Natl Mil Med Ctr, Natl Intrepid Ctr Excellence, 4860 South Palmer Rd, Bethesda, MD 20889 USA. [Dretsch, Michael N.] Headquarters Army Training & Doctrine Command HQ, Human Dimens Div, 950 Jefferson Ave, Ft Eustis, VA 23604 USA. [Emmerich, Tanja; Crynen, Gogce; Ait-Ghezala, Ghania; Chaytow, Helena; Mathura, Venkat; Crawford, Fiona C.] Roskamp Inst, 2040 Whitfield Ave, Sarasota, FL 34243 USA. [Iverson, Grant L.] Harvard Univ, Sch Med, Dept Phys Med & Rehabil, Boston, MA USA. [Iverson, Grant L.] Spaulding Rehabil Hosp, Boston, MA USA. [Iverson, Grant L.] Red Sox Fdn, Boston, MA USA. [Iverson, Grant L.] Massachusetts Gen Hosp, Home Base Program, Boston, MA 02114 USA. [Iverson, Grant L.] Def & Vet Brain Injury Ctr, Bethesda, MD USA. [Iverson, Grant L.] Harvard Univ, Sch Med, Ctr Hlth & Rehabil, Dept Phys Med & Rehabil, 79-96 Thirteenth St, Charlestown, MA 02129 USA. RP Dretsch, MN (reprint author), HQ TRADOC, Human Dimens Div, 950 Jefferson Ave, Ft Eustis, VA USA. EM michael.n.dretsch.mil@mail.mil FU US Army Medical Research and Materiel Command FX Funding for this study was provided by the US Army Medical Research and Materiel Command. NR 65 TC 2 Z9 2 U1 3 U2 13 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 2162-3279 J9 BRAIN BEHAV JI Brain Behav. PD JAN PY 2016 VL 6 IS 1 AR e00392 DI 10.1002/brb3.392 PG 12 WC Behavioral Sciences; Neurosciences SC Behavioral Sciences; Neurosciences & Neurology GA DB8OV UT WOS:000368777200006 PM 27110438 ER PT J AU Johnson, PC Roberts, AD Hire, JM Mueller, TL AF Johnson, Peter C. Roberts, Aaron D. Hire, Justin M. Mueller, Terry L. TI The Effect of Instrumentation on Suture Tensile Strength and Knot Pullout Strength of Common Suture Materials SO JOURNAL OF SURGICAL EDUCATION LA English DT Article DE knot security; suture strength; suture material AB OBJECTIVE: To determine the effect of instrumentation of suture material on knot security and tensile strength. STUDY DESIGN: In all, 5 types of suture material were used; 10 knots were tied without any instrumentation and 10 knots were tied with a hemostat holding tension on the first throw while the second throw was made for each suture type. Each group was tested to failure with the maximum load and mode of failure recorded. The maximum load between groups of each suture type was compared; frequency of failure through knot slippage vs material fracture was also compared between groups. RESULTS: There was no significant difference observed in the maximum load to failure for any suture type between instrumented and noninstrumented groups. Additionally, there was no difference between any instrumented and noninstrumented groups for material failure vs failure due to knot slippage. CONCLUSIONS: Instrumentation of suture material during two-hand tying does not affect the strength of suture material or knot security. (Published by Elsevier Inc on behalf of the Association of Program Directors in Surgery) C1 [Johnson, Peter C.; Roberts, Aaron D.; Hire, Justin M.; Mueller, Terry L.] Dwight D Eisenhower Army Med Ctr, Dept Orthopaed Surg, Ft Gordon, GA USA. [Johnson, Peter C.; Roberts, Aaron D.; Hire, Justin M.; Mueller, Terry L.] Dwight D Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA USA. RP Johnson, PC (reprint author), Dept Orthopaed Surg, 300 East Hosp Rd, Ft Gordon, GA 30905 USA. EM peter.c.johnson.mil@mail.mil FU Department of Clinical Investigation, Dwight D. Eisenhower Army Medical Center; DCI FX Funding for the purchase of suture materials was provided by the Department of Clinical Investigation, Dwight D. Eisenhower Army Medical Center. DCI provided the funding with the intention of generating an article for publication, and provided facilities and equipment for data collection. DCI had no role in study design, or in data analysis or interpretation. NR 6 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1931-7204 EI 1878-7452 J9 J SURG EDUC JI J. Surg. Educ. PD JAN-FEB PY 2016 VL 73 IS 1 BP 162 EP 165 DI 10.1016/j.jsurg.2015.08.011 PG 4 WC Education, Scientific Disciplines; Surgery SC Education & Educational Research; Surgery GA DB2BR UT WOS:000368313800024 PM 26422001 ER PT J AU Hourani, L Williams, J Bray, RM Wilk, JE Hoge, CW AF Hourani, Laurel Williams, Jason Bray, Robert M. Wilk, Joshua E. Hoge, Charles W. TI Gender Differences in Posttraumatic Stress Disorder and Help Seeking in the US Army SO JOURNAL OF WOMENS HEALTH LA English DT Article ID POSTDEPLOYMENT MENTAL-HEALTH; SERVICE UTILIZATION; MILITARY PERSONNEL; CARE UTILIZATION; PTSD SYMPTOMS; VETERANS; IRAQ; COMBAT; AFGHANISTAN; DUTY AB Background: Inconsistent findings between studies of gender differences in mental health outcomes in military samples have left open questions of differential prevalence in posttraumatic stress disorder (PTSD) among all United States Army soldiers and in differential psychosocial and comorbid risk and protective factor profiles and their association with receipt of treatment. Methods: This study assesses the prevalence and risk factors of screening positive for PTSD for men and women based on two large, population-based Army samples obtained as part of the 2005 and 2008 U.S. Department of Defense Surveys of Health Related Behaviors among Active Duty Military Personnel. Results: The study showed that overall rates of PTSD, as measured by several cutoffs of the PTSD Checklist, are similar between active duty men and women, with rates increasing in both men and women between the two study time points. Depression and problem alcohol use were strongly associated with a positive PTSD screen in both genders, and combat exposure was significantly associated with a positive PTSD screen in men. Overall, active duty men and women who met criteria for PTSD were equally likely to receive mental health counseling or treatment, though gender differences in treatment receipt varied by age, race, social support (presence of spouse at duty station), history of sexual abuse, illness, depression, alcohol use, and combat exposure. Conclusions: The study demonstrates that the prevalence of PTSD as well as the overall utilization of mental health services is similar for active duty men compared with women. However, there are significant gender differences in predictors of positive PTSD screens and receipt of PTSD treatment. C1 [Hourani, Laurel; Williams, Jason; Bray, Robert M.] RTI Int, Res Triangle Pk, NC USA. [Wilk, Joshua E.; Hoge, Charles W.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci Res, Silver Spring, MD USA. RP Hourani, L (reprint author), RTI Int, 3040 Cornwallis Dr, Res Triangle Pk, NC USA. EM Hourani@rti.org FU U.S. Army [W81XWH-10-F-0444] FX This research was supported by contract number W81XWH-10-F-0444 from the U.S. Army. This article represents the views of the authors and is not an official position of the U.S. Army. The authors thank Mr. Justin Faerber and Anne Gering for their editorial assistance. NR 38 TC 2 Z9 2 U1 4 U2 24 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-9996 EI 1931-843X J9 J WOMENS HEALTH JI J. Womens Health PD JAN 1 PY 2016 VL 25 IS 1 BP 22 EP 31 DI 10.1089/jwh.2014.5078 PG 10 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Obstetrics & Gynecology; Women's Studies SC Public, Environmental & Occupational Health; General & Internal Medicine; Obstetrics & Gynecology; Women's Studies GA DB4YX UT WOS:000368520700006 PM 26562624 ER PT J AU Molgaard, JJ Auxier, JD Giminaro, AV Oldham, CJ Gill, J Hall, HL AF Molgaard, Joshua J. Auxier, John D., II Giminaro, Andrew V. Oldham, Colton J. Gill, Jonathan Hall, Howard L. TI Production of Synthetic Nuclear Melt Glass SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS LA English DT Article DE Engineering; Issue 107; nuclear weapons; nuclear debris; melt glass; trinitite; vitrify; amorphous; crystalline ID DEBRIS; WASTE AB Realistic surrogate nuclear debris is needed within the nuclear forensics community to test and validate post-detonation analysis techniques. Here we outline a novel process for producing bulk surface debris using a high temperature furnace. The material developed in this study is physically and chemically similar to trinitite (the melt glass produced by the first nuclear test). This synthetic nuclear melt glass is assumed to be similar to the vitrified material produced near the epicenter (ground zero) of any surface nuclear detonation in a desert environment. The process outlined here can be applied to produce other types of nuclear melt glass including that likely to be formed in an urban environment. This can be accomplished by simply modifying the precursor matrix to which this production process is applied. The melt glass produced in this study has been analyzed and compared to trinitite, revealing a comparable crystalline morphology, physical structure, void fraction, and chemical composition. C1 [Molgaard, Joshua J.] US Mil Acad, Dept Phys & Nucl Engn, West Point, NY 10996 USA. [Auxier, John D., II; Giminaro, Andrew V.; Oldham, Colton J.; Gill, Jonathan; Hall, Howard L.] Univ Tennessee, Dept Nucl Engn, Knoxville, TN 37996 USA. [Auxier, John D., II; Giminaro, Andrew V.; Hall, Howard L.] Univ Tennessee, Radiochem Ctr Excellence RCoE, Knoxville, TN 37996 USA. [Hall, Howard L.] Univ Tennessee, Inst Nucl Secur, Knoxville, TN 37996 USA. RP Molgaard, JJ (reprint author), US Mil Acad, Dept Phys & Nucl Engn, West Point, NY 10996 USA. EM Joshua.Molgaard@usma.edu OI Hall, Howard/0000-0002-4080-5159; Auxier II, John /0000-0001-6234-6451 FU Stewardship Science Academic Alliances (SSAA) Program of the National Nuclear Security Administration (NNSA) [DE-NA0001983] FX This work was performed under grant number DE-NA0001983 from the Stewardship Science Academic Alliances (SSAA) Program of the National Nuclear Security Administration (NNSA). NR 23 TC 0 Z9 0 U1 0 U2 5 PU JOURNAL OF VISUALIZED EXPERIMENTS PI CAMBRIDGE PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA SN 1940-087X J9 JOVE-J VIS EXP JI J. Vis. Exp. PD JAN PY 2016 IS 107 AR e53473 DI 10.3791/53473 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DB5TV UT WOS:000368577400027 ER PT S AU Slipher, GA Haynes, RA Riddick, JC AF Slipher, Geoffrey A. Haynes, Robert A. Riddick, Jaret C. BE Ralph, C Silberstein, M Thakre, PR Singh, R TI Electrical Impedance Spectroscopy for Structural Health Monitoring SO MECHANICS OF COMPOSITE AND MULTIFUNCTIONAL MATERIALS, VOL 7 SE Conference Proceedings of the Society for Experimental Mechanics Series LA English DT Proceedings Paper CT Annual Conference and Exposition of Society-for-Experimental-Mechanics on Experimental and Applied Mechanics CY JUN 08-11, 2015 CL Costa Mesa, CA SP Soc Experimental Mech DE Electrical impedance spectroscopy; Structural health monitoring; Carbon fiber; Fatigue state; Damage state detection; Load state detection ID DAMAGE DETECTION; COMPOSITES AB In-situ structural health monitoring systems on vehicles have the potential to enable on-demand material state awareness capability and eliminate the need for lengthy and costly down-times. Further, the information collected from a structural health monitoring system can be used to predict the remaining useful life of a structure or component. Electrical impedance spectroscopy is an emerging method of interrogating carbon fiber reinforced polymer composite materials subject to cyclic loading to determine the current damage state. This technique has the benefit of using the composite itself as the sensing material, thereby not requiring additional sensing material be placed into the composite. Information can be extracted from changes in both the phase and the impedance magnitude of the signal. Previous work found that special care must be taken to ensure that damage to the leads does not affect the results. In this work, a single interrogation path is examined to determine the usefulness of the single-path approach and the nature of the changes in impedance as they relate to fatigue life. C1 [Slipher, Geoffrey A.; Haynes, Robert A.; Riddick, Jaret C.] US Army, Res Lab, Vehicle Technol Directorate, 4603 Flare Loop, Aberdeen Proving Ground, MD 21005 USA. RP Haynes, RA (reprint author), US Army, Res Lab, Vehicle Technol Directorate, 4603 Flare Loop, Aberdeen Proving Ground, MD 21005 USA. EM robert.a.haynes43.civ@mail.mil NR 10 TC 1 Z9 1 U1 4 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 2191-5644 BN 978-3-319-21762-8; 978-3-319-21761-1 J9 C PROC SOC EXP MECH PY 2016 BP 41 EP 48 DI 10.1007/978-3-319-21762-8_5 PG 8 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA BE1SW UT WOS:000368488900005 ER PT S AU Li, WL Brown, EN Rae, PJ Gazonas, G Negahban, M AF Li, Wenlong Brown, Eric N. Rae, Philip J. Gazonas, George Negahban, Mehrdad BE Ralph, C Silberstein, M Thakre, PR Singh, R TI Mechanical Characterization and Preliminary Modeling of PEEK SO MECHANICS OF COMPOSITE AND MULTIFUNCTIONAL MATERIALS, VOL 7 SE Conference Proceedings of the Society for Experimental Mechanics Series LA English DT Proceedings Paper CT Annual Conference and Exposition of Society-for-Experimental-Mechanics on Experimental and Applied Mechanics CY JUN 08-11, 2015 CL Costa Mesa, CA SP Soc Experimental Mech DE Poly-ether-ether-ketone (PEEK); Equilibrium stress; Plastic flow; Anisotropic elasticity; Mechanical modeling ID GLASSY POLYCARBONATE; ANISOTROPIES; EVOLUTION; SHEAR AB Poly-ether-ether-ketone (PEEK) is a high-performance semi-crystalline polymer with mechanical and thermal stability characteristics that are superior to most tough polymers. The mechanical characteristics of this polymer are modeled over a broad range of mechanical loading conditions using a thermodynamically consistent modeling process. This preliminary model, which ignores the thermal response and the possible recrystallization of this material during loading, shows an outstanding ability to capture the multidimensional nonlinear response of PEEK up to 60 % compression, with loading rates from 0.0001 to 3000 1/s at room temperature. The model includes the measured anisotropy in the wave response that develops with plastic flow, captures the evolution of the measured equilibrium stress, and correctly matches the evolution of the tangent modulus at equilibrium. This broad range of rates and experimental conditions are achieved by using a two-element nonlinear thermodynamically-consistent model. C1 [Li, Wenlong; Negahban, Mehrdad] Univ Nebraska, Mech & Mat Engn, Lincoln, NE 68588 USA. [Brown, Eric N.; Rae, Philip J.] Los Alamos Natl Lab, POB 1663, Los Alamos, NM 87545 USA. [Gazonas, George] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Negahban, M (reprint author), Univ Nebraska, Mech & Mat Engn, Lincoln, NE 68588 USA. EM mnegahban@unl.edu OI Brown, Eric/0000-0002-6812-7820 NR 15 TC 0 Z9 0 U1 3 U2 8 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 2191-5644 BN 978-3-319-21762-8; 978-3-319-21761-1 J9 C PROC SOC EXP MECH PY 2016 BP 209 EP 218 DI 10.1007/978-3-319-21762-8_25 PG 10 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA BE1SW UT WOS:000368488900025 ER PT S AU Pankow, M McWilliams, BA AF Pankow, Mark McWilliams, Brandon A. BE Ralph, C Silberstein, M Thakre, PR Singh, R TI Simulation of High Rate Failure Mechanisms in Composites During Quasi-static Testing SO MECHANICS OF COMPOSITE AND MULTIFUNCTIONAL MATERIALS, VOL 7 SE Conference Proceedings of the Society for Experimental Mechanics Series LA English DT Proceedings Paper CT Annual Conference and Exposition of Society-for-Experimental-Mechanics on Experimental and Applied Mechanics CY JUN 08-11, 2015 CL Costa Mesa, CA SP Soc Experimental Mech DE Composites; Penetration mechanics; Dynamic failure mechanisms; High strain rate behavior ID WOVEN COMPOSITES; STRAIN-RATE AB High Rate testing is often difficult to perform, requires specialized equipment and often had results that are difficult to interpret. Being able to simulate the same failure mechanisms at high rates would enable rapid material selection. In this experimental investigation, the mechanical response is determined of different hybrid composites materials. A modified through-the-thickness tests has been used to force a high order of failure mode that is similar to those seen in high speed impact. Failure is observed in the samples and stresses on the surface are determine to help with failure envelope measurements. The details of a comparison between 2D fabrics vs. 3D woven fabrics has been under taken and a comparison will be presented showing the similarities and differences in response. A discussion of the comparison between the high rate testing and the low-rate testing will be investigated and discussion on the applications of the testing will be examined for failure envelope prediction. C1 [Pankow, Mark] N Carolina State Univ, Dept Mech & Aerosp Engn, Raleigh, NC 27695 USA. [McWilliams, Brandon A.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Pankow, M (reprint author), N Carolina State Univ, Dept Mech & Aerosp Engn, Raleigh, NC 27695 USA. EM mrpankow@ncsu.edu NR 7 TC 0 Z9 0 U1 2 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 2191-5644 BN 978-3-319-21762-8; 978-3-319-21761-1 J9 C PROC SOC EXP MECH PY 2016 BP 445 EP 450 DI 10.1007/978-3-319-21762-8_52 PG 6 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA BE1SW UT WOS:000368488900052 ER PT S AU McWilliams, BA Yu, JH Pankow, M AF McWilliams, Brandon A. Yu, Jian H. Pankow, Mark BE Bossuyt, S Schajer, G Carpinteri, A TI Dynamic Failure Mechanisms in Woven Ceramic Fabric Reinforced Metal Matrix Composites During Ballistic Impact SO RESIDUAL STRESS, THERMOMECHANICS & INFRARED IMAGING, HYBRID TECHNIQUES AND INVERSE PROBLEMS, VOL 9 SE Conference Proceedings of the Society for Experimental Mechanics Series LA English DT Proceedings Paper CT Annual Conference and Exposition of Society-for-Experimental-Mechanics on Experimental and Applied Mechanics CY JUN 08-11, 2015 CL Costa Mesa, CA SP Soc Experimental Mech DE Metal matrix composites; Penetration mechanics; Dynamic failure mechanisms; Failure modeling; High strain rate behavior ID ALUMINUM AB The complex interaction of dynamic stress waves during ballistic impact provides the opportunity to simultaneously observe the high strain rate loading response under various triaxialities including tension, compression, and shear. In this work the dynamic failure mechanisms of woven ceramic fabric reinforced aluminum metal matrix composites (MMC) during ballistic impact are experimentally investigated. In addition to experimental characterization, an orthotropic elastic-plastic constitutive model with hydrostatic pressure dependent yield is implemented in an explicit finite element code to quantify the stress states present during the progressive damage and failure of the MMC during the penetration and perforation process. C1 [McWilliams, Brandon A.; Yu, Jian H.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Pankow, Mark] N Carolina State Univ, Dept Mech & Aerosp Engn, Raleigh, NC 27695 USA. RP McWilliams, BA (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM brandon.a.mcwilliams.civ@mail.mil NR 15 TC 0 Z9 0 U1 3 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 2191-5644 BN 978-3-319-21765-9; 978-3-319-21764-2 J9 C PROC SOC EXP MECH PY 2016 BP 155 EP 159 DI 10.1007/978-3-319-21765-9_20 PG 5 WC Engineering, Mechanical; Materials Science, Multidisciplinary; Mechanics SC Engineering; Materials Science; Mechanics GA BE1SX UT WOS:000368490000020 ER PT S AU Yu, JH McWilliams, BA Kaste, RP AF Yu, Jian H. McWilliams, Brandon A. Kaste, Robert P. BE Bossuyt, S Schajer, G Carpinteri, A TI Digital Image Correlation Analysis and Numerical Simulation of the Aluminum Alloys under Quasi-static Tension after Necking Using the Bridgman's Method SO RESIDUAL STRESS, THERMOMECHANICS & INFRARED IMAGING, HYBRID TECHNIQUES AND INVERSE PROBLEMS, VOL 9 SE Conference Proceedings of the Society for Experimental Mechanics Series LA English DT Proceedings Paper CT Annual Conference and Exposition of Society-for-Experimental-Mechanics on Experimental and Applied Mechanics CY JUN 08-11, 2015 CL Costa Mesa, CA SP Soc Experimental Mech DE Bridgman's correction; Digital image correlation; Necking; FEM; Tensile; Stress-strain AB The Bridgman method of true stress correction in tensile loading is revisited. With the current advances in 3D DIC technique, the implementation of the Bridgman method becomes very simple. The equivalent true stress-strain relation from the correction is readily and directly implementable into FEM simulation. The Bridgman method can yield a high degree of accuracy in predicting flow stress in post-necking for some aluminum alloys, especially where the radius of curvature around the neck is small before failure. However, if the actual triaxiality deviates too much from the uniaxial assumption that it is constant across the neck radius, the Bridgman's correction would still over estimate the equivalent stress. Subsequent FEM simulation can determine whether the Bridgman's correction is adequate to predict the true stress-strain relation beyond necking. C1 [Yu, Jian H.; McWilliams, Brandon A.; Kaste, Robert P.] Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Yu, JH (reprint author), Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM jian.h.yu.civ@mail.mil NR 3 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 2191-5644 BN 978-3-319-21765-9; 978-3-319-21764-2 J9 C PROC SOC EXP MECH PY 2016 BP 161 EP 166 DI 10.1007/978-3-319-21765-9_21 PG 6 WC Engineering, Mechanical; Materials Science, Multidisciplinary; Mechanics SC Engineering; Materials Science; Mechanics GA BE1SX UT WOS:000368490000021 ER PT J AU Stapanian, MA Lewis, TE Palmer, CJ Amos, MM AF Stapanian, Martin A. Lewis, Timothy E. Palmer, Craig J. Amos, Molly M. TI Assessing accuracy and precision for field and laboratory data: a perspective in ecosystem restoration SO RESTORATION ECOLOGY LA English DT Review DE accuracy; ecosystem restoration; field calibration; precision; QA/QC ID MULTIVARIATE ENVIRONMENTAL DATA; LAKE-ERIE; 2 TESTS; SCALE; REPEATABILITY; ASSESSMENTS; DISTURBANCE; INTEGRITY; OUTLIERS; QUALITY AB Unlike most laboratory studies, rigorous quality assurance/quality control (QA/QC) procedures may be lacking in ecosystem restoration (ecorestoration) projects, despite legislative mandates in the United States. This is due, in part, to ecorestoration specialists making the false assumption that some types of data (e.g. discrete variables such as species identification and abundance classes) are not subject to evaluations of data quality. Moreover, emergent behavior manifested by complex, adapting, and nonlinear organizations responsible for monitoring the success of ecorestoration projects tend to unconsciously minimize disorder, QA/QC being an activity perceived as creating disorder. We discuss similarities and differences in assessing precision and accuracy for field and laboratory data. Although the concepts for assessing precision and accuracy of ecorestoration field data are conceptually the same as laboratory data, the manner in which these data quality attributes are assessed is different. From a sample analysis perspective, a field crew is comparable to a laboratory instrument that requires regular recalibration, with results obtained by experts at the same plot treated as laboratory calibration standards. Unlike laboratory standards and reference materials, the true value for many field variables is commonly unknown. In the laboratory, specific QA/QC samples assess error for each aspect of the measurement process, whereas field revisits assess precision and accuracy of the entire data collection process following initial calibration. Rigorous QA/QC data in an ecorestoration project are essential for evaluating the success of a project, and they provide the only objective legacy of the dataset for potential legal challenges and future uses. C1 [Stapanian, Martin A.] US Geol Survey, Great Lakes Sci Ctr, Lake Erie Biol Stn, 6100 Columbus Ave, Sandusky, OH 44870 USA. [Lewis, Timothy E.] US Army Corps Engn, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. [Palmer, Craig J.; Amos, Molly M.] CSC, 6361 Walker Lane, Alexandria, VA 22310 USA. RP Stapanian, MA (reprint author), US Geol Survey, Great Lakes Sci Ctr, Lake Erie Biol Stn, 6100 Columbus Ave, Sandusky, OH 44870 USA. EM mstapanian@usgs.gov OI Stapanian, Martin/0000-0001-8173-4273 FU U.S. Environmental Protection Agency [EP-C-12-008] FX We thank two anonymous reviewers and the editor for comments on the original submission. J. Aron, H. Clavien, A. Friona, L. Walker, and M. Loomis reviewed previous drafts. L. Blume provided valuable suggestions, comments, and encouragement. Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the U.S. government. This article is Contribution Number 1970 of the U.S. Geological Survey Great Lakes Science Center. Some of the information in this document has been funded by the U.S. Environmental Protection Agency under contract number EP-C-12-008 to CSC. Although some of the research described in this article has been funded by the U.S. Environmental Protection Agency, it has not been subjected to Agency review. Any opinions expressed in this publication are those of the author(s) and do not, necessarily, reflect the official positions and policies of the U.S. EPA. Any mention of products or trade names does not constitute recommendation for use by the U.S. EPA. NR 66 TC 1 Z9 1 U1 2 U2 11 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1061-2971 EI 1526-100X J9 RESTOR ECOL JI Restor. Ecol. PD JAN PY 2016 VL 24 IS 1 BP 18 EP 26 DI 10.1111/rec.12284 PG 9 WC Ecology SC Environmental Sciences & Ecology GA DB6QB UT WOS:000368638700004 ER PT J AU Kreyer, S Scaravilli, V Linden, K Belenkiy, SM Necsoiu, C Li, YS Putensen, C Chung, KK Batchinsky, AI Cancio, LC AF Kreyer, Stefan Scaravilli, Vittorio Linden, Katharina Belenkiy, Slava M. Necsoiu, Corina Li, Yansong Putensen, Christian Chung, Kevin K. Batchinsky, Andriy I. Cancio, Leopoldo C. TI EARLY UTILIZATION OF EXTRACORPOREAL CO2 REMOVAL FOR TREATMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME DUE TO SMOKE INHALATION AND BURNS IN SHEEP SO SHOCK LA English DT Article DE Acute respiratory distress syndrome; burns; extracorporeal lung support; mechanical ventilation; smoke inhalation injury ID CARBON-DIOXIDE REMOVAL; EXPERIMENTAL PULMONARY CONTUSION; PRESSURE RELEASE VENTILATION; INTERVENTIONAL LUNG ASSIST; MECHANICAL VENTILATION; MEMBRANE-OXYGENATION; AIRWAY PRESSURE; 6 ML/KG; SYSTEM; INJURY AB Introduction:In thermally injured patients, inhalation injury is often associated with acute respiratory distress syndrome (ARDS), and is an independent predictor of increased morbidity and mortality. Extracorporeal CO2 removal (ECCO2R) therapy offers new possibilities in protective mechanical ventilation in ARDS patients. We performed an early application of ECCO2R in mild-to-moderate ARDS in sheep ventilated in BiPAP mode. Our aim was to investigate its effect on severity of the lung injury.Material and Methods:Non-pregnant farm-bred ewes (n=15) were anesthetized and injured by a combination of wood-bark smoke inhalation and a 40% total body surface area full-thickness burn, and were observed for 72h or death. The animals were randomized to a Hemolung group (n=7) or a Control group (n=8) at time of ARDS onset. ECCO2R was performed in the Hemolung group after onset of ARDS.Histopathology, CT scans, systemic and pulmonary variables, and CO2 removal were examined.Results:Early application of ECCO2R therapy with Hemolung in spontaneously breathing sheep decreased PaCO2 significantly, while the device removed about 70mL of CO2 per minute. This did not result in lower minute ventilation in the Hemolung group. Lungpathology and CT scans did not show a difference between groups.Conclusion:In an ovine model of ARDS due to smoke inhalation and burn injury, early institution of ECCO2R in spontaneously breathing animals was effective in removing CO2 and in reducing PaCO2. However, it had no effect on reducing the severity of lung injury or mortality. Further studies are necessary to detail the interaction between extracorporeal CO2 removal and pulmonary physiology. C1 [Kreyer, Stefan; Putensen, Christian] Univ Hosp Bonn, Dept Anesthesiol & Intens Care Med, D-53125 Bonn, Germany. [Kreyer, Stefan; Scaravilli, Vittorio; Linden, Katharina; Belenkiy, Slava M.; Necsoiu, Corina; Li, Yansong; Chung, Kevin K.; Batchinsky, Andriy I.; Cancio, Leopoldo C.] US Army, Inst Surg Res, JBSA Ft Sam Houston, Killeen, TX USA. [Scaravilli, Vittorio] Univ Milano Bicocca, Dipartimento Sci Salute, Monza, MB, Italy. [Linden, Katharina] Univ Hosp Bonn, Dept Pediat, Bonn, Germany. [Belenkiy, Slava M.] W Virginia Univ, Sch Med, Dept Anesthesiol, Morgantown, WV USA. [Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Kreyer, S (reprint author), Univ Hosp Bonn, Dept Anesthesiol & Intens Care Med, D-53125 Bonn, Germany. EM Stefan.Kreyer@uni-bonn.de FU U.S. Department of Energy; U.S. Army Medical Research and Materiel Command; U.S. Army Medical Research and Materiel Command (USAMRMC); Telemedicine and Advanced Technology Research Center (TATRC) [12340055]; Comprehensive Intensive Care Research Task Area, Combat Casualty Care Research Program, U.S. Army Medical Research and Materiel Command, Fort Detrick, MD FX This research was supported in part by appointment of one of the authors (LCC) to the Knowledge Preservation Program at the U.S. Army Institute of Surgical Research, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and the U.S. Army Medical Research and Materiel Command.; This study was funded by U.S. Army Medical Research and Materiel Command (USAMRMC) and the Telemedicine and Advanced Technology Research Center (TATRC) entitled: "Transportable Life Support for Treatment of Acute Lung Failure Due to Smoke Inhalation and Burns", Log No 12340055. Principal Investigator of the study is AIB. As part of this effort Alung Inc., the manufacturer of the Hemolung CO2 removal system, provided membranes and a data monitoring console to conduct the experiments. No other financial support was provided by the company.; Supported by the Comprehensive Intensive Care Research Task Area, Combat Casualty Care Research Program, U.S. Army Medical Research and Materiel Command, Fort Detrick, MD. NR 37 TC 2 Z9 2 U1 2 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD JAN PY 2016 VL 45 IS 1 BP 65 EP 72 DI 10.1097/SHK.0000000000000471 PG 8 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DB4QW UT WOS:000368499200011 PM 26674455 ER PT J AU Netherland, MD Richardson, RJ AF Netherland, Michael D. Richardson, Robert J. TI Evaluating Sensitivity of Five Aquatic Plants to a Novel Arylpicolinate Herbicide Utilizing an Organization for Economic Cooperation and Development Protocol SO WEED SCIENCE LA English DT Article DE Aquatic herbicide; aquatic plant bioassay; aquatic plant toxicity; Beck's water-marigold; herbicide screening; invasive aquatic plants ID EURASIAN WATERMILFOIL; MYRIOPHYLLUM-SPICATUM; HYBRID WATERMILFOIL; TRICLOPYR; FLURIDONE; EXPOSURE; HYDRILLA; EFFICACY; DOCUMENTATION; MACROPHYTES AB New arylpicolinate herbicide chemistry under development for rice, aquatic weed management, and other uses was evaluated using five aquatic plants. The herbicide 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoro-pyridine-2-benzyl ester-also identified as XDE-848 BE or SX-1552 (proposed International Organization for Standardization common name in review; active tradename Rinskor (TM))-and its acid form (XDE-848 acid or SX-1552A) were evaluated on three dicots: (1) Eurasian watermilfoil (EWM), (2) megalodonta, and (3) crested floating heart (CFH), and two monocots: (1) hydrilla and (2) elodea. A small-scale Organization for Economic Cooperation and Development (OECD) protocol developed using EWM for registration studies was utilized. EWM and megalodonta were also evaluated in larger-scale mesocosms for comparison. In-water concentrations between 0.01 and 243 mg ai L-1 as SX-1552 or SX-1552A were applied under static conditions for 14 (growth chamber) or 28 d (mesocosm). EWM was susceptible to both SX-1552 and SX-1552A, with dry-weight 50% effective concentration (EC50) values of 0.11 and 0.23 mu g ai L-1 under growth chamber conditions. Megalodonta had EC50 values of 11.3 and 14.5 mu g ai L-1 for the SX-1552 and SX-1552A. CFH was more sensitive to SX-1552 (EC50 5 5.6 mu g ai L-1) than to SX-1552A (EC50 5 23.9 mu g ai L-1). Hydrilla had EC50 values of 1.4 and 2.5 mu g ai L-1, whereas elodea was more tolerant, with EC50 values of 6.9 and 13.1 mu g ai L-1 for SX-1552 and SX-1552A, respectively. For EWM mesocosm trials, EC50 values for SX-1552 and 1552A were 0.12 mu g ai L-1 and 0.58 mu g ai L-1, whereas the megalodonta EC50 was 6.1 mu g ai L-1. Activity of SX-1552 on EWM, hydrilla, and CFH merits continued investigation for selective aquatic weed control properties. Results suggest that the OECD protocol can be used to screen activity of herbicides for multiple aquatic plant species. C1 [Netherland, Michael D.] US Army Engineer Res & Dev Ctr, Gainesville, FL 32653 USA. N Carolina State Univ, Raleigh, NC 27695 USA. RP Netherland, MD (reprint author), US Army Engineer Res & Dev Ctr, 7922 NW 71st St, Gainesville, FL 32653 USA. EM Michael.D.Netherland@usace.army.mil FU U.S. Army Engineer Research and Development Center; Aquatic Plant Control Research Program; Aquatic Ecosystem Restoration Foundation FX The assistance of Jesse Stevens with study setup and data collection is greatly appreciated. Funding for this project was provided through the U.S. Army Engineer Research and Development Center, Aquatic Plant Control Research Program and through the Aquatic Ecosystem Restoration Foundation. Citation of trade names does not constitute endorsement or approval of the use of such commercial products. Permission to publish this paper was granted by the Chief of Engineers. NR 37 TC 1 Z9 1 U1 3 U2 7 PU WEED SCI SOC AMER PI LAWRENCE PA 810 EAST 10TH ST, LAWRENCE, KS 66044-8897 USA SN 0043-1745 EI 1550-2759 J9 WEED SCI JI Weed Sci. PD JAN-MAR PY 2016 VL 64 IS 1 BP 181 EP 190 DI 10.1614/WS-D-15-00092.1 PG 10 WC Agronomy; Plant Sciences SC Agriculture; Plant Sciences GA DB1IY UT WOS:000368263100021 ER PT J AU Brooks, BW Lazorchak, JM Howard, MDA Johnson, MVV Morton, SL Perkins, DAK Reavie, ED Scott, GI Smith, SA Steevens, JA AF Brooks, Bryan W. Lazorchak, James M. Howard, Meredith D. A. Johnson, Mari-Vaughn V. Morton, Steve L. Perkins, Dawn A. K. Reavie, Euan D. Scott, Geoffrey I. Smith, Stephanie A. Steevens, Jeffery A. TI Are Harmful Algal Blooms Becoming the Greatest Inland Water Quality Threat to Public Health and Aquatic Ecosystems? SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Harmful algae; Climate change; Urbanization; Agriculture; Salinization; Lake and reservoir monitoring; Toxin; Ambient toxicity; Essential services of environmental public health ID PRYMNESIUM-PARVUM BLOOMS; PERSONAL CARE PRODUCTS; CLIMATE-CHANGE; LAKE-ERIE; EUTROPHICATION; CYANOBACTERIA; BIODIVERSITY; ENVIRONMENT; QUESTIONS; IMPACTS AB In this Focus article, the authors ask a seemingly simple question: Are harmful algal blooms (HABs) becoming the greatest inland water quality threat to public health and aquatic ecosystems? When HAB events require restrictions on fisheries, recreation, and drinking water uses of inland water bodies significant economic consequences result. Unfortunately, the magnitude, frequency, and duration of HABs in inland waters are poorly understood across spatiotemporal scales and differentially engaged among states, tribes, and territories. Harmful algal bloom impacts are not as predictable as those from conventional chemical contaminants, for which water quality assessment and management programs were primarily developed, because interactions among multiple natural and anthropogenic factors determine the likelihood and severity to which a HAB will occur in a specific water body. These forcing factors can also affect toxin production. Beyond site-specific water quality degradation caused directly by HABs, the presence of HAB toxins can negatively influence routine surface water quality monitoring, assessment, and management practices. Harmful algal blooms present significant challenges for achieving water quality protection and restoration goals when these toxins confound interpretation of monitoring results and environmental quality standards implementation efforts for other chemicals and stressors. Whether HABs presently represent the greatest threat to inland water quality is debatable, though in inland waters of developed countries they typically cause more severe acute impacts to environmental quality than conventional chemical contamination events. The authors identify several timely research needs. Environmental toxicology, environmental chemistry, and risk-assessment expertise must interface with ecologists, engineers, and public health practitioners to engage the complexities of HAB assessment and management, to address the forcing factors for HAB formation, and to reduce the threats posed to inland surface water quality. (C) 2015 SETAC C1 [Brooks, Bryan W.] Baylor Univ, Dept Environm Sci, Ctr Reservoir & Aquat Syst Res, Inst Biomed Studies, Waco, TX 76798 USA. [Lazorchak, James M.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. [Howard, Meredith D. A.] Southern Calif Coastal Water Res Project, Costa Mesa, CA USA. [Johnson, Mari-Vaughn V.] Nat Resources Conservat Serv, USDA, Temple, TX USA. [Morton, Steve L.] NOAA, Natl Ctr Coastal Ocean Sci, Ctr Coastal Environm Hlth & Biomol Res, Charleston, SC USA. [Perkins, Dawn A. K.] Univ Wisconsin, Wisconsin State Lab Hyg, Madison, WI 53706 USA. [Reavie, Euan D.] Univ Minnesota, Nat Resources Res Inst, Ctr Water & Environm, Duluth, MN 55811 USA. [Scott, Geoffrey I.] Univ S Carolina, Arnold Sch Publ Hlth, Dept Environm Hlth Sci, Columbia, SC 29208 USA. [Smith, Stephanie A.] Beagle Bioprod, Columbus, OH USA. [Steevens, Jeffery A.] US Army Engn Res & Dev Ctr, Vicksburg, MS USA. RP Brooks, BW (reprint author), Baylor Univ, Dept Environm Sci, Ctr Reservoir & Aquat Syst Res, Inst Biomed Studies, Waco, TX 76798 USA. EM bryan_brooks@baylor.edu RI Brooks, Bryan/B-2612-2010; Guenat, Heather/H-6528-2014; OI Brooks, Bryan/0000-0002-6277-9852; Lazorchak, James/0000-0002-7354-7571 FU Fulbright Visiting Research Chair in Water and the Environment at the University of Lethbridge, Alberta, Canada FX Permission was granted by the US Army Corps of Engineers chief of engineers to publish this material. The information in this document has been subjected to review by the USEPA, the US Department of Agriculture, and the National Oceanic and Atmospheric Administration and has been approved for publication. The views expressed in this column are those of the authors and do not necessarily represent the views or policies of the USEPA, the US Department of Agriculture, or the National Oceanic and Atmospheric Administration. During the development of this column, B.W. Brooks was supported as the Fulbright Visiting Research Chair in Water and the Environment at the University of Lethbridge, Alberta, Canada, and as a Visiting Erskine Fellow at the University of Canterbury, Christchurch, New Zealand. NR 48 TC 9 Z9 9 U1 52 U2 152 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD JAN PY 2016 VL 35 IS 1 BP 6 EP 13 DI 10.1002/etc.3220 PG 8 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA DA9KI UT WOS:000368127200001 PM 26771345 ER PT J AU Stanley, JK Laird, JG Kennedy, AJ Steevens, JA AF Stanley, Jacob K. Laird, Jennifer G. Kennedy, Alan J. Steevens, Jeffery A. TI SUBLETHAL EFFECTS OF MULTIWALLED CARBON NANOTUBE EXPOSURE IN THE INVERTEBRATE DAPHNIA MAGNA SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Behavioral toxicology; Nanoecotoxicology; Aquatic toxicology; Multiwalled carbon nanotube; Natural organic matter; Aquatic invertebrate ID TITANIUM-DIOXIDE; TOXICITY; GROWTH; REPRODUCTION; MORTALITY; NANOPARTICLES; NANOMATERIALS; BIOASSAYS; FOOD AB Carbon nanotubes were previously demonstrated to accumulate on the carapace and in the gut of daphnids in aquatic exposures. The purpose of the present study was to assess the effects of multiwalled carbon nanotube (MWCNT) exposure on the sublethal Daphnia magna endpoints swimming behavior, algal feeding, growth, and reproduction and to determine the relative magnitude of difference between lethal and sublethal toxicity thresholds in 48-h and 14-d exposures. A stable dispersion of MWCNTs was prepared using 100 mg/L natural organic matter (NOM), and all treatments were compared statistically to a NOM control. The swimming behavior endpoints of mean velocity and total distance moved were determined using digital tracking software. For the acute (48-h) exposure, a 50% lethal concentration (LC50) of 29.3 (23.6-36.3) mg/L and a 50% effective concentration (EC50) of 6.7 mg/L in the swimming velocity endpoint were determined. When swimming response was nonmonotonic below 2 mg/L, consistent reductions in velocity were observed at 6.9 mg/L and above. Median effect concentrations were lower in the chronic (14-d) bioassay. The 14-d LC50 was 4.3 mg/L (3.3-5.6 mg/L), and the reproduction EC50 was 5.0 mg/L. Lowest-observed-effect concentrations for survival and reproduction were 5.4 mg/L and 1.7 mg/L, respectively. Significantly fewer (23.1%) algal cells were consumed in the 3.9-mg/L treatment relative to the control. No significant effects on swimming behavior were observed for the 14-d bioassay. Less traditional sublethal endpoints such as swimming behavior and feeding rate may be especially important to assess for MWCNTs and other materials expected to be more physically than chemically toxic through mechanisms such as gut clogging. Published 2015 Wiley Periodicals Inc. on behalf of SETAC. This article is a US Government work and is in the public domain in the United States of America. C1 [Stanley, Jacob K.; Laird, Jennifer G.; Kennedy, Alan J.; Steevens, Jeffery A.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Stanley, JK (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. EM jacob.k.stanley@us.army.mil FU US Army's Environmental Quality Technology Research Program FX Permission was granted by the chief of engineers to publish the present study. The present study was funded by the US Army's Environmental Quality Technology Research Program (E. Ferguson, Technical Director). NR 26 TC 1 Z9 1 U1 6 U2 29 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD JAN PY 2016 VL 35 IS 1 BP 200 EP 204 DI 10.1002/etc.3184 PG 5 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA DA9KI UT WOS:000368127200024 PM 26222333 ER PT J AU Hoke, R Huggett, D Brasfield, S Brown, B Embry, M Fairbrother, A Kivi, M Paumen, ML Prosser, R Salvito, D Scroggins, R AF Hoke, Robert Huggett, Duane Brasfield, Sandra Brown, Becky Embry, Michelle Fairbrother, Anne Kivi, Michelle Paumen, Miriam Leon Prosser, Ryan Salvito, Dan Scroggins, Rick TI Review of Laboratory-Based Terrestrial Bioaccumulation Assessment Approaches for Organic Chemicals: Current Status and Future Possibilities SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Review DE Terrestrial; Bioaccumulation assessment; Chemical regulation; POPs; Wildlife ID PHYSIOLOGICAL PHARMACOKINETIC MODELS; POLYCYCLIC AROMATIC-HYDROCARBONS; NORTHERN BOBWHITE QUAIL; PARTITION-COEFFICIENTS; HUMAN PHARMACEUTICALS; DIFFERENTIAL UPTAKE; ALUMINUM-OXIDE; PLANT UPTAKE; FOOD-CHAINS; FIELD AB In the last decade, interest has been renewed in approaches for the assessment of the bioaccumulation potential of chemicals, principally driven by the need to evaluate large numbers of chemicals as part of new chemical legislation, while reducing vertebrate test organism use called for in animal welfare legislation. This renewed interest has inspired research activities and advances in bioaccumulation science for neutral organic chemicals in aquatic environments. In January 2013, ILSI Health and Environmental Sciences Institute convened experts to identify the state of the science and existing shortcomings in terrestrial bioaccumulation assessment of neutral organic chemicals. Potential modifications to existing laboratory methods were identified, including areas in which new laboratory approaches or test methods could be developed to address terrestrial bioaccumulation. The utility of "non-ecotoxicity" data (e. g., mammalian laboratory data) was also discussed. The highlights of the workshop discussions are presented along with potential modifications in laboratory approaches and new test guidelines that could be used for assessing the bioaccumulation of chemicals in terrestrial organisms. Integr Environ Assess Manag 2016; 12: 109-122. (C) 2015 SETAC C1 [Hoke, Robert] DuPont Co Inc, Haskell Global Centers Hlth & Environm Sci, Newark, DC USA. [Huggett, Duane] Univ N Texas, Denton, TX 76203 USA. [Brasfield, Sandra] US Army, Engn Res & Dev Ctr, Vicksburg, MS USA. [Brown, Becky] AstraZeneca, Global Environm, Chester, Cheshire, England. [Embry, Michelle] LSI HESI, Washington, DC USA. [Fairbrother, Anne] Exponent, Bellevue, WA USA. [Kivi, Michelle] PMRA, Hlth Canada, Ottawa, ON, Canada. [Paumen, Miriam Leon] ExxonMobil Biomed Sci, Machelen, Belgium. [Prosser, Ryan] Univ Guelph, Guelph, ON N1G 2W1, Canada. [Salvito, Dan] RIFM, Woodcliff Lake, NJ USA. [Scroggins, Rick] Environm Canada, Ottawa, ON K1A 0H3, Canada. RP Hoke, R (reprint author), DuPont Co Inc, Haskell Global Centers Hlth & Environm Sci, Newark, DC 94545 USA. EM robert.a.hoke@dupont.com FU International Life Sciences Institute; Health and Environmental Sciences Institute FX We thank the International Life Sciences Institute, Health and Environmental Sciences Institute for sponsoring the "Terrestrial Bioaccumulation Workshop," January 8-10, 2013 in Miami, Florida. MK also specifically acknowledges input from N Kavaslar, M Gerrits, M Beauchamp, C Bowes and R Gangaraju of the Health and Environment Directorates, PMRA. The authors also thank the anonymous reviewers for their review comments which helped improve the manuscript. The authors have no conflicts of interest to declare that affect the publication of this manuscript. NR 115 TC 0 Z9 0 U1 7 U2 26 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD JAN PY 2016 VL 12 IS 1 BP 109 EP 122 DI 10.1002/ieam.1692 PG 14 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA DA6KV UT WOS:000367914100010 PM 26272585 ER PT J AU van den Brink, NW Arblaster, JA Bowman, SR Conder, JM Elliott, JE Johnson, MS Muir, DCG Natal-da-Luz, T Rattner, BA Sample, BE Shore, RF AF van den Brink, Nico W. Arblaster, Jennifer A. Bowman, Sarah R. Conder, Jason M. Elliott, John E. Johnson, Mark S. Muir, Derek C. G. Natal-da-Luz, Tiago Rattner, Barnett A. Sample, Bradley E. Shore, Richard F. TI Use of Terrestrial Field Studies In the Derivation of Bioaccumulation Potential of Chemicals SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Article DE Biomagnification factors; Biota-to-soil-accumulation factors; BMF; BSAF; Chemical bioaccumulation; Terrestrial food web; TMF; Trophic magnification factors ID PERSISTENT ORGANIC POLLUTANTS; BROMINATED FLAME RETARDANTS; TROPHIC MAGNIFICATION FACTORS; POLLUTION EXPOSURE ASSESSMENT; HEDGEHOG ERINACEUS-EUROPAEUS; LICHEN-CARIBOU-WOLF; MARINE FOOD-WEB; BIOMONITORING TOOL; STABLE-ISOTOPES; TEMPORAL TRENDS AB Field-based studies are an essential component of research addressing the behavior of organic chemicals, and a unique line of evidence that can be used to assess bioaccumulation potential in chemical registration programs and aid in development of associated laboratory and modeling efforts. To aid scientific and regulatory discourse on the application of terrestrial field data in this manner, this article provides practical recommendations regarding the generation and interpretation of terrestrial field data. Currently, biota-to-soil-accumulation factors (BSAFs), biomagnification factors (BMFs), and bioaccumulation factors (BAFs) are the most suitable bioaccumulation metrics that are applicable to bioaccumulation assessment evaluations and able to be generated from terrestrial field studies with relatively low uncertainty. Biomagnification factors calculated from field-collected samples of terrestrial carnivores and their prey appear to be particularly robust indicators of bioaccumulation potential. The use of stable isotope ratios for quantification of trophic relationships in terrestrial ecosystems needs to be further developed to resolve uncertainties associated with the calculation of terrestrial trophic magnification factors (TMFs). Sampling efforts for terrestrial field studies should strive for efficiency, and advice on optimization of study sample sizes, practical considerations for obtaining samples, selection of tissues for analysis, and data interpretation is provided. Although there is still much to be learned regarding terrestrial bioaccumulation, these recommendations provide some initial guidance to the present application of terrestrial field data as a line of evidence in the assessment of chemical bioaccumulation potential and a resource to inform laboratory and modeling efforts. Integr Environ Assess Manag 2016; 12: 135-145. (C) 2015 SETAC C1 [van den Brink, Nico W.] Wageningen Univ, Subdept Toxicol, NL-6700 AP Wageningen, Netherlands. [Arblaster, Jennifer A.] Ramba Environ Corp, Irvine, CA USA. [Bowman, Sarah R.] Ohio State Univ, Dept Evolut Ecol & Organismal Biol, Columbus, OH 43210 USA. [Conder, Jason M.] Geosyntec Consultants, Huntington Beach, CA USA. [Elliott, John E.] Environm Canada, Delta, BC, Canada. [Johnson, Mark S.] US Army, Publ Hlth Ctr, Aberdeen, MD USA. [Muir, Derek C. G.] Environm Canada, Burlington, ON, Canada. [Natal-da-Luz, Tiago] Univ Coimbra, Ctr Funct Ecol, Dept Life Sci, Coimbra, Portugal. [Rattner, Barnett A.] US Geol Survey, Patuxent Wildlife Res Ctr, Beltsville, MD USA. [Sample, Bradley E.] Ecol Risk, Rancho Murieta, CA USA. [Shore, Richard F.] NERC, Ctr Ecol & Hydrol, Lancaster, England. RP van den Brink, NW (reprint author), Wageningen Univ, Subdept Toxicol, NL-6700 AP Wageningen, Netherlands. EM nico.vandenbrink@wur.nl RI Shore, Richard/A-2638-2012 OI Shore, Richard/0000-0002-9337-8883 NR 107 TC 1 Z9 1 U1 6 U2 17 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD JAN PY 2016 VL 12 IS 1 BP 135 EP 145 DI 10.1002/ieam.1717 PG 11 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA DA6KV UT WOS:000367914100012 PM 26436822 ER PT J AU Kwan, J Hoverson, K Arora, NS AF Kwan, Julia Hoverson, Kara Arora, Navin S. TI A scaly eruption on the body SO INTERNATIONAL JOURNAL OF DERMATOLOGY LA English DT Editorial Material ID DERMATITIS NEGLECTA; DERMATOSIS C1 [Kwan, Julia] Naval Hlth Clin Hawaii, Dermatol Serv, Joint Base Pearl Harbor Hickham, Honolulu, HI USA. [Hoverson, Kara] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Arora, Navin S.] Tripler Army Med Ctr, Dermatol Serv, Honolulu, HI 96859 USA. RP Hoverson, K (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM Kara.hoverson@gmail.com NR 6 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0011-9059 EI 1365-4632 J9 INT J DERMATOL JI Int. J. Dermatol. PD JAN PY 2016 VL 55 IS 1 BP E4 EP E6 DI 10.1111/ijd.13063 PG 3 WC Dermatology SC Dermatology GA DA8XG UT WOS:000368089600002 PM 26463106 ER PT J AU Pollett, S Leguia, M Nelson, MI Berry, IM Rutherford, G Bausch, DG Kasper, M Jarman, R Melendrez, M AF Pollett, S. Leguia, M. Nelson, M. I. Berry, I. Maljkovic Rutherford, G. Bausch, D. G. Kasper, M. Jarman, R. Melendrez, M. TI Feasibility and effectiveness of a brief, intensive phylogenetics workshop in a middle-income country SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE Phylogenetics; Bioinformatics; Training; Low- and middle-income country; Viral pathogens ID PHYLOGEOGRAPHY; VIRUS AB There is an increasing role for bioinformatic and phylogenetic analysis in tropical medicine research. However, scientists working in low- and middle-income regions may lack access to training opportunities in these methods. To help address this gap, a 5-day intensive bioinformatics workshop was offered in Lima, Peru. The syllabus is presented here for others who want to develop similar programs. To assess knowledge gained, a 20-point knowledge questionnaire was administered to participants (21 participants) before and after the workshop, covering topics on sequence quality control, alignment/formatting, database retrieval, models of evolution, sequence statistics, tree building, and results interpretation. Evolution/tree-building methods represented the lowest scoring domain at baseline and after the workshop. There was a considerable median gain in total knowledge scores (increase of 30%, p < 0.001) with gains as high as 55%. A 5-day workshop model was effective in improving the pathogen-applied bioinformatics knowledge of scientists working in a middle-income country setting. (C) 2015 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. C1 [Pollett, S.; Leguia, M.; Bausch, D. G.] US Naval Med Res Unit 6, Lima, Peru. [Pollett, S.; Rutherford, G.] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA. [Pollett, S.] Univ Sydney, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia. [Nelson, M. I.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. [Berry, I. Maljkovic; Jarman, R.; Melendrez, M.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Kasper, M.] Armed Forces Hlth Surveillance Ctr, Global Emerging Infect Surveillance & Response Sy, Silver Spring, MD USA. RP Pollett, S (reprint author), US Naval Med Res Unit 6, Lima, Peru. EM spollett@med.usyd.edu.au OI Melendrez, Melanie/0000-0002-4811-4467 FU Global Emerging Infections Surveillance and Response System (GEIS), a division of the Armed Forces Health Surveillance Center (AFHSC) FX The authors thank Ana Sofia Rengifo and the Universidad Peruana Cayetano Heredia for their assistance. This work was supported by the Global Emerging Infections Surveillance and Response System (GEIS), a division of the Armed Forces Health Surveillance Center (AFHSC). NR 9 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 EI 1878-3511 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD JAN PY 2016 VL 42 BP 24 EP 27 DI 10.1016/j.ijid.2015.11.001 PG 4 WC Infectious Diseases SC Infectious Diseases GA DA8FK UT WOS:000368040300006 PM 26571303 ER PT J AU Cuda, JP Shearer, JF Weeks, ENI Kariuki, E Baniszewski, J Giurcanu, M AF Cuda, James P. Shearer, Judy F. Weeks, Emma N. I. Kariuki, Eutychus Baniszewski, Julie Giurcanu, Mihai TI Compatibility of an insect, a fungus, and a herbicide for integrated pest management of dioecious hydrilla SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE Cricotopus lebetis; herbicide-resistance management; Hydrilla verticillata; imazamox; integrated weed management; Mycoleptodiscus terrestris ID CRICOTOPUS-LEBETIS DIPTERA; BIOLOGICAL-CONTROL AGENT; VERTICILLATA HYDROCHARITACEAE; NORTH-AMERICA; AQUATIC WEED; TIP MINER; CHIRONOMIDAE; FLURIDONE; PATHOGEN; MACROPHYTES AB During the past 15 yr dioecious hydrilla (Hydrilla verticillata) in Florida developed resistance to fluridone and endothall, two registered herbicides approved for aquatic use. An integrated pest management approach could mitigate the effects of herbicide resistance and improve the sustainability of dioecious hydrilla management in Florida. In this study, we tested a reduced-risk method for dioecious hydrilla control by integrating selective insect herbivory with a disease organism or low concentrations of a new herbicide recently registered for aquatic use. Two rates of the fungal pathogen Mycoleptodiscus terrestris (Mt) and the acetolactate synthase-inhibiting herbicide imazamox, and two densities of the hydrilla tipmining midge Cricotopus lebetis alone and in combination were randomly applied to aquaria containing established hydrilla plants and replicated three times. Hydrilla shoots in each tank were harvested,similar to 30 d after the treatments were applied. Hydrilla biomass produced in each treatment was compared. Results showed that combining the hydrilla tipmining midge C. lebetis with either the Mt fungus or herbicide imazamox significantly reduced hydrilla growth and the effects in some treatments were synergistic. Furthermore, C. lebetis was compatible with the herbicide imazamox; adult emergence of C. lebetis was similar in aquaria treated with imazamox compared with untreated controls. Incorporating biological control agents like Mt and the tip-mining midge C. lebetis into an integrated weed-management strategy could reduce overreliance on herbicides and provide a more sustainable solution to Florida's dioecious hydrilla problem. C1 [Cuda, James P.; Weeks, Emma N. I.; Baniszewski, Julie] Univ Florida, Dept Entomol & Nematol, Gainesville, FL 32611 USA. [Shearer, Judy F.] US Army Engineer Res 8c Dev Ctr, Environm Lab, Waterways Expt Stn, Vicksburg, MS 39180 USA. [Giurcanu, Mihai] Univ Florida, IFAS Stat, Gainesville, FL 32611 USA. RP Cuda, JP (reprint author), Univ Florida, Dept Entomol & Nematol, Gainesville, FL 32611 USA. EM jcuda@ufl.edu FU National Institute of Food and Agriculture, U.S. Department of Agriculture [2010-02825]; Weed Science Society of America (Undergraduate Research Award) FX We thank Jan Freedman, Verena-Ulrike Lietze, Alissa Berro, and Karen Stratman for their technical support. We also thank Bill Overholt, Lyn Gettys, and Mike Netherland for their comments on an earlier draft of this manuscript. This material is based upon work that is supported by the National Institute of Food and Agriculture, U.S. Department of Agriculture, under award number 2010-02825, and the Weed Science Society of America (Undergraduate Research Award). NR 56 TC 0 Z9 0 U1 7 U2 20 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JAN PY 2016 VL 54 BP 20 EP 25 PG 6 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA DA7DP UT WOS:000367965100003 ER PT J AU Richardson, RJ Haug, EJ Netherland, MD AF Richardson, Robert J. Haug, Erika J. Netherland, Michael D. TI Response of seven aquatic plants to a new arylpicolinate herbicide SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE herbicidal control; synthetic auxin ID WATERMILFOIL MYRIOPHYLLUM-SPICATUM; EURASIAN WATERMILFOIL; HYBRID WATERMILFOIL; TRICLOPYR; RESISTANCE; FLURIDONE; AUXIN; SIBIRICUM; HYDRILLA; EFFICACY AB The herbicide 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoro-pyridine-2-benzyl ester (SX-1552 or XDE-848 BE; proposed ISO common name in review) is a new arylpicolinate herbicide currently under development for weed management in rice (Oryza sativa L.) production, aquatic weed management, and other uses. Greenhouse research was conducted to evaluate the effect of SX-1552 and SX-1552A (an acid metabolite) on seven aquatic plants: alligatorweed [Alternanthera philoxeroides (Mart.) Grisebd, Carolina waterhyssop [Bacopa monnieri (L.) Pennell], fanwort (Cabomba caroliniana Gray), monoecious hydrilla [Hydrilla verticillata (L. f.) Royle], parrotfeather [Myriophyllum aquaticum (Vell.) Verdcd, variable watermilfoil (Myriophyllum heterophyllum Michx.), and American waterwillow [Justicia americana (L.) Vahl]. SX-1552 and SX-1552A were applied to these species as an in-water, 4-wk static exposure at rates of 0 to 81 mu g L-1. Fanwort was not controlled by SX-1552 at the rates evaluated, in contrast to the other species tested. Dry weight 50% effective concentration (EC50) values were <1 mu g L-1 SX-1552 for alligatorWeed, monoecious hydrilla, parrotfeather, and variable watermilfoil. Carolina waterhyssop and American waterwillow SX-1552 EC50 values were 5.0 and 5.1 mu g L-1, respectively. These six species were less sensitive to SX-1552A with dry weight EC50 values of 1.6 to 77.1 mu g L-1. Plant control ratings also indicated that response of the six sensitive species increased from 2 to 4 wk after treatment. Further research is needed on additional species as well as concentration exposure-time determination for the species evaluated here. C1 [Richardson, Robert J.; Haug, Erika J.] N Carolina State Univ, Dept Crop Sci, Raleigh, NC 27695 USA. [Netherland, Michael D.] US Army Engineer Res & Dev Ctr, Gainesville, FL 32653 USA. RP Richardson, RJ (reprint author), N Carolina State Univ, Dept Crop Sci, Box 7620, Raleigh, NC 27695 USA. EM rob_richardson@ncsu.edu NR 33 TC 0 Z9 0 U1 3 U2 9 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JAN PY 2016 VL 54 BP 26 EP 31 PG 6 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA DA7DP UT WOS:000367965100004 ER PT J AU Mudge, CR Perret, AJ Winslow, JR AF Mudge, Christopher R. Perret, Alexander J. Winslow, Jonathan R. TI Evaluation of foliar herbicide and surfactant combinations for control of giant salvinia at three application timings SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE adjuvant; carfentrazone-ethyl; chemical control; diquat; endothall; flumioxazin; glyphosate; Salvinia molesta; surfactant; tank mix ID WATER TEMPERATURE; SUBMERSED PLANTS; GLYPHOSATE; MOLESTA; EFFICACY; DIQUAT; RESISTANCE; ENDOTHALL AB The invasive aquatic fern, giant salvinia (Salvinia molesta Mitchell). continues to spread throughout Louisiana, Texas, and the Gulf Coast Region. Most infestations in Louisiana are chemically managed throughout the growing season with a combination of the aquatic herbicides glyphosate and diquat plus two adjuvants (nonionic surfactant with buffering agents and a nonionic organosilicone surfactant). Heavy reliance on one spray mixture is of concern to natural resource managers because of the possibility of developing herbicide resistance. In addition, it is unknown whether combinations of other herbicides and adjuvants or surfactants can provide improved efficacy at certain times of the year (i.e., seasonal differences) compared with the primary treatment used operationally. Therefore, three mesocosm trials were conducted in the spring, summer, and fall to evaluate the efficacy of various combinations of glyphosate, carfentrazone-ethyl (hereafter, called carfentrazone), diquat, endothall, flumioxazin, and adjuvants on giant salvinia. All treatments involving glyphosate carfentrazone or flumioxazin, as well as endothall flumioxazin, resulted in giant salvinia injury 1 d after treatment. Glyphosate alone required 4 d to produce injury symptoms. All treatments, regardless of application time, were efficacious against giant salvinia 7 wk after treatment and reduced plant dry weight by 65 to 99% compared with the nontreated control. In general, fall herbicide treatments were less efficacious than the spring or summer treatments, and a great amount of regrowth also occurred following this application. The substitution of carfentrazone or flumioxazin for diquat into the glyphosate spray mixture, as well as other surfactants or adjuvants, provided similar control to the herbicide mixture used operationally in Louisiana. Based on these data, the new mixtures evaluated in the spring and summer can be viable alternatives to manage salvinia during the growing season. Further research is needed to evaluate other mixes for the fall when plant growth is decreasing. C1 [Mudge, Christopher R.] Louisiana State Univ, US Army Engineer Res & Dev Ctr, Sch Plant Environm & Soil Sci, Baton Rouge, LA 70803 USA. [Perret, Alexander J.; Winslow, Jonathan R.] Louisiana Dept Wildlife & Fisheries, Baton Rouge, LA 70898 USA. RP Mudge, CR (reprint author), Louisiana State Univ, US Army Engineer Res & Dev Ctr, Sch Plant Environm & Soil Sci, Baton Rouge, LA 70803 USA. EM Christopher.R.Mudge@usace.army.mil FU U.S. Army Engineer Research and Development Center Aquatic Plant Control Research Program; Louisiana Department of Wildlife and Fisheries FX This research was supported by the U.S. Army Engineer Research and Development Center Aquatic Plant Control Research Program and the Louisiana Department of Wildlife and Fisheries. The authors thank Dr. Michael Netherland and Lee Ann Glomski for providing reviews of this manuscript. Permission was granted by the Chief of Engineers to publish this information. Citation of trade names does not constitute endorsement or approval of the use of such commercial products. NR 34 TC 0 Z9 0 U1 7 U2 21 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JAN PY 2016 VL 54 BP 32 EP 36 PG 5 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA DA7DP UT WOS:000367965100005 ER PT J AU Glomski, L Netherland, MD AF Glomski, Leeann Netherland, Michael D. TI Impact of herbicide retention time on the efficacy of foliar treatments for control of crested floating heart SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article ID GLYPHOSATE; RAINFALL; RAINFASTNESS; JOHNSONGRASS C1 [Glomski, Leeann] US Army Corps Engineers, St Paul, MN 55155 USA. [Netherland, Michael D.] US Army Engineer Res & Dev Ctr, Ctr Aquat & Invas Plants, Gainesville, FL 32653 USA. RP Netherland, MD (reprint author), US Army Engineer Res & Dev Ctr, Ctr Aquat & Invas Plants, Gainesville, FL 32653 USA. EM mdnether@ufl.edu FU U.S. Army Engineer Research and Development Center Aquatic Plant Control Program FX This research was supported by the U.S. Army Engineer Research and Development Center Aquatic Plant Control Program. The authors thank Jonathan Ward and Josh Wood for their technical assistance. Permission was granted by the Chief of Engineers to publish this information. Citation of trade names does not constitute endorsement or approval of the use of such commercial products. NR 15 TC 0 Z9 0 U1 1 U2 3 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JAN PY 2016 VL 54 BP 50 EP 52 PG 3 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA DA7DP UT WOS:000367965100008 ER PT J AU Stutelberg, MW Dzisam, JK Monteil, AR Petrikovics, I Boss, GR Patterson, SE Rockwood, GA Logue, BA AF Stutelberg, Michael W. Dzisam, Joseph K. Monteil, Alexandre R. Petrikovics, Ilona Boss, Gerry R. Patterson, Steven E. Rockwood, Gary A. Logue, Brian A. TI Simultaneous determination of 3-mercaptopyruvate and cobinamide in plasma by liquid chromatography-tandem mass spectrometry SO JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES LA English DT Article DE Cyanide antidote; Sulfanegen; Mass spectrometry ID CORE WAVE-GUIDE; CYANIDE ANTIDOTE; SULFANEGEN SODIUM; NITRIC-OXIDE; HYDROXOCOBALAMIN; DETOXIFICATION; VITAMIN-B12; COBALAMIN; SULFURTRANSFERASES; IDENTIFICATION AB The current suite of Food and Drug Administration (FDA) approved antidotes (i.e., sodium nitrite, sodium thiosulfate, and hydroxocobalamin) are effective for treating cyanide poisoning, but individually, each antidote has major limitations (e.g., large effective dosage or delayed onset of action). To mitigate these limitations, next-generation cyanide antidotes are being investigated, including 3-mercaptopyruvate (3-MP) and cobinamide (Cbi). Analytical methods capable of detecting these therapeutics individually and simultaneously (for combination therapy) are essential for the development of 3-MP and Cbi as potential cyanide antidotes. Therefore, a liquid chromatography tandem mass-spectrometry method for the simultaneous analysis of 3-MP and Cbi was developed. Sample preparation of 3-MP consisted of spiking plasma with an internal standard (C-13(3)-3-MP), precipitation of plasma proteins, and derivatizing 3-MP with monobromobimane to produce 3-mercaptopyruvate-bimane. Preparation of Cbi involved denaturing plasma proteins with simultaneous addition of excess cyanide to convert each Cbi species to dicyanocobinamide (Cbi(CN)(2)). The limits of detection for 3-MP and Cbi were 0.5 mu M and 0.2 mu M, respectively. The linear ranges were 2-500 mu M for 3-MP and 0.5-50 mu M for Cbi. The accuracy and precision for 3-MP were 100 +/- 9% and <8.3% relative standard deviation (RSD), respectively. For Cbi(CN)(2), the accuracy was 100 +/- 13% and the precision was <9.5% RSD. The method presented here was used to determine 3-MP and Cbi from treated animals and may ultimately facilitate FDA approval of these antidotes for treatment of cyanide poisoning. (C) 2015 Elsevier By. All rights reserved. C1 [Stutelberg, Michael W.; Dzisam, Joseph K.; Logue, Brian A.] S Dakota State Univ, Dept Chem & Biochem, Avera Hlth & Sci Ctr 131, Brookings, SD 57007 USA. [Monteil, Alexandre R.; Patterson, Steven E.] Univ Minnesota, Ctr Drug Design, Minneapolis, MN 55455 USA. [Petrikovics, Ilona] Sam Houston State Univ, Dept Chem, Huntsville, TX 77341 USA. [Boss, Gerry R.] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA. [Rockwood, Gary A.] US Army Med Res Inst Chem Def, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA. RP Logue, BA (reprint author), S Dakota State Univ, Dept Chem & Biochem, Avera Hlth & Sci Ctr 131, Box 2202, Brookings, SD 57007 USA. EM brian.logue@sdstate.edu OI Logue, Brian/0000-0002-2400-9339 FU Counter-ACT Program; National Institutes of Health Office of the Director (NIH OD); National Institute of Allergy and Infectious Diseases [Y1-OD-0690-01/A-120-B.P2010-01, Y1 -OD-1561-01/A120-B.P2011-01, AOD14020-001-00000/A120-B.P2014-01, AOD13016-001-00000/A120-B.P2013-01, AOD12060-001-00000/A120-B.P2012-01]; U.S. Dept. of Education GAANN award [P200A100103]; National Science Foundation Major Research Instrumentation Program [CHE-0922816, EPSCoR Grant 0091948]; National Science Foundation/EPSCoR [0091948] FX We gratefully acknowledge the support from the Counter-ACT Program, National Institutes of Health Office of the Director (NIH OD), and the National Institute of Allergy and Infectious Diseases, (Grant Number Y1-OD-0690-01/A-120-B.P2010-01, Y1 -OD-1561-01/A120-B.P2011-01, AOD14020-001-00000/A120-B.P2014-01, AOD13016-001-00000/A120-B.P2013-01, AOD12060-001-00000/A120-B.P2012-01). We also would like to acknowledge support by U.S. Dept. of Education GAANN award (P200A100103). We thank the National Science Foundation Major Research Instrumentation Program (Grant Number CHE-0922816) for funding the AB SCIEX QTRAP 5500 LC/MS/MS (EPSCoR Grant 0091948). Lastly, we would like to thank the South Dakota State University Campus Mass Spectrometry Facility for the use of the LC-MS-MS, obtained with the support from the National Science Foundation/EPSCoR (Grant Number 0091948). The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the national Science Foundation, the National Institute of Health, or Department of Defense. NR 39 TC 1 Z9 1 U1 4 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1570-0232 EI 1873-376X J9 J CHROMATOGR B JI J. Chromatogr. B PD JAN 1 PY 2016 VL 1008 BP 181 EP 188 DI 10.1016/j.jchromb.2015.11.027 PG 8 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA DB0NT UT WOS:000368205500024 PM 26655110 ER PT J AU Nadal-Caraballo, NC Melby, JA Gonzalez, VM AF Nadal-Caraballo, Norberto C. Melby, Jeffrey A. Gonzalez, Victor M. TI Statistical Analysis of Historical Extreme Water Levels for the US North Atlantic Coast Using Monte Carlo Life-Cycle Simulation SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE Statistical analysis; extreme value analysis; historical water levels; Monte Carlo life-cycle simulation; generalized Pareto distribution; peaks-over-threshold; partial duration series ID UNCERTAINTIES; EVENTS; SERIES AB A statistical analysis of extreme water levels was performed for 23 locations throughout the U.S. North Atlantic coast. Extreme value analysis, which focused on historical observations, was followed by the application of a Monte Carlo life-cycle simulation methodology. This study was part of a broader effort to quantify coastal flooding hazards in this region. Twenty-three stations were selected based on location and record length, meeting the requirement of a minimum of 30 years of hourly water-level measurements. Monthly maxima data were also used to complement the hourly water-level observations. The use of available water-level data was maximized through the development of partial duration series that combined both monthly maxima and hourly data. A generalized Pareto distribution was used to fit combined partial duration series corresponding to each of the 23 locations. The Monte Carlo life-cycle methodology was used to simulate 10,000 cycles of 100 years each, effectively extending the record lengths of extreme events through statistical simulation. A bootstrapping technique was used as part of Monte Carlo life-cycle simulation in order to, develop probability distributions of extreme water levels, including mean, as well as 10% and 90% nonexceedance confidence limits (equivalent to an 80% confidence interval). Water-level probabilities determined in this study were compared to results from a previous effort where the generalized extreme value distribution was used to fit monthly maxima data. C1 [Nadal-Caraballo, Norberto C.; Melby, Jeffrey A.; Gonzalez, Victor M.] US Army, Engn Res & Dev Ctr, Coastal Hydraul Lab, Vicksburg, MS 39180 USA. RP Nadal-Caraballo, NC (reprint author), US Army, Engn Res & Dev Ctr, Coastal Hydraul Lab, Vicksburg, MS 39180 USA. EM norberto.c.nadal-caraballo@usace.army.mil FU U.S. Army Corps of Engineers as part of North Atlantic Coast Comprehensive Study (NACCS) FX This study was sponsored by the U.S. Army Corps of Engineers as part of the North Atlantic Coast Comprehensive Study (NACCS). The research described herein was conducted at the U.S. Army Engineer Research and Development Center, Coastal and Hydraulics Laboratory. The data and assistance provided by Chris Zervas and Michael Michalski of NOAA-NOS CO-OPS were greatly appreciated. The authors also appreciate the constructive comments of the anonymous reviews. NR 28 TC 1 Z9 1 U1 2 U2 12 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI COCONUT CREEK PA 5130 NW 54TH STREET, COCONUT CREEK, FL 33073 USA SN 0749-0208 EI 1551-5036 J9 J COASTAL RES JI J. Coast. Res. PD JAN PY 2016 VL 32 IS 1 BP 35 EP 45 DI 10.2112/JCOASTRES-D-15-00031.1 PG 11 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA DB0UA UT WOS:000368221800002 ER PT J AU Cheng, J Wang, P Smith, ER AF Cheng, Jun Wang, Ping Smith, Ernest R. TI Hydrodynamic Conditions Associated with an Onshore Migrating and Stable Sandbar SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE Sandbar migration; equilibrium beach profile; undertow; velocity skewness and asymmetry; physical model ID WEST-CENTRAL FLORIDA; INDUCED SEDIMENT TRANSPORT; DOPPLER-VELOCIMETER DATA; SURF-ZONE; SHEET FLOW; BEACH; NEARSHORE; BREAKING; MODEL; WAVES AB In this study, large-scale three-dimensional laboratory data were analyzed to identify the hydrodynamic conditions associated with the onshore migration of a sandbar and the subsequent equilibrium state of a stable bar. The initial sandbar was constructed offshore and out of equilibrium, with a symmetrical shape. The bar became asymmetrical as it migrated onshore. As the rate of onshore migration slowed, the bar was restored to a symmetrical shape toward an equilibrium state. Wave and near-bottom velocity across the surf zone were measured during the onshore sandbar migration. The near-bottom velocity skewness analyzed wave by wave indicates that before the sandbar reached equilibrium, the velocity was skewed offshore in the nearshore region and was skewed onshore seaward of the bar. However, the velocity skewness pattern reversed when the beach profile reached equilibrium and the sandbar became stable. The location of maximum undertow velocity moved from nearshore to the bar crest as the sandbar evolved toward equilibrium. Furthermore, the peak onshore-directed acceleration was greater than the peak offshore-directed acceleration throughout the surf zone during the periods of both onshore migrating and stable sandbar. The maximum difference between the onshore- and the offshore-directed acceleration occurred at the seaward side of the bar crest. The analyses of the hydrodynamic conditions associated with sandbar movement in a controlled laboratory experiment provide insights on the mechanisms of sandbar migration. C1 [Cheng, Jun; Wang, Ping] Univ S Florida, Sch Geosci, Tampa, FL 33620 USA. [Smith, Ernest R.] US Army Engn Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Cheng, J (reprint author), Univ S Florida, Sch Geosci, Tampa, FL 33620 USA. EM jun@mail.usf.edu FU graduate school of University of South Florida; U.S. Army Engineer Research and Development Center FX This study is jointly funded by the U.S. Army Engineer Research and Development Center and the graduate school of the University of South Florida. Permission to publish this paper was granted by the Headquarters, U.S. Army Corps of Engineers. NR 44 TC 0 Z9 0 U1 1 U2 4 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI COCONUT CREEK PA 5130 NW 54TH STREET, COCONUT CREEK, FL 33073 USA SN 0749-0208 EI 1551-5036 J9 J COASTAL RES JI J. Coast. Res. PD JAN PY 2016 VL 32 IS 1 BP 153 EP 163 DI 10.2112/JCOASTRES-D-14-00174.1 PG 11 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA DB0UA UT WOS:000368221800012 ER PT J AU Morang, A AF Morang, Andrew TI Hurricane Barriers in New England and New Jersey: History and Status after Five Decades SO JOURNAL OF COASTAL RESEARCH LA English DT Review DE Hurricane surge; Fox Point; New Bedford; Pawcatuck; Stamford; New London; Raritan Bay; Charles River Dam; Boston; Providence; Great New England Hurricane; Hurricane Carol; Hurricane Sandy AB Massachusetts, Rhode Island, Connecticut, and New Jersey suffered damage, flooding, and deaths from three major hurricanes in less than two decades during the mid-twentieth century. One of these, the Great New England Hurricane of 21 September 1938, caused unprecedented damage and flooded Providence, New London, and other urban areas. Following Hurricane Carol in 1954, the 84th Congress (1st Session, Public Law 71, 15 June 1955) authorized and directed the Secretary of the Army to conduct surveys and studies of damages, causes, and remediation measures with regard to hurricanes. After extensive studies during the late 1950s, Congress authorized and funded seven hurricane protection projects: (1) in Fox Point, Providence, Rhode Island, a barrier, navigation gates, and pumps; (2) in New Bedford, Massachusetts, a barrier, navigation gates, and pumps; (3) in New London, Connecticut, a barrier and navigation gate; (4) in Pawcatuck, Connecticut, earthfill and concrete walls; (5) in Stamford, Connecticut, a barrier and pump station; (6) in Raritan and Sandy Hook Bays, New Jersey, levees, beach fill, and pumps; and (7) in Charles River, Boston, Massachusetts, a dam with locks and pumps. Most of the projects have not been tested with storm-water elevations near their design elevation. Exceptions are the Charles River dam, which helped prevent flooding during the Blizzard of 1978, and Raritan Bay, during Hurricane Sandy. For lower levels, all projects have performed as designed. After the flooding caused by Hurricane Sandy in 2012, comprehensive hurricane barriers have been proposed for the New York area. Many major challenges would confront planners and designers of new hurricane barriers in the New York Bight area compared to the earlier projects: (1) Far more extensive environmental impact studies would have to be conducted now; (2) obtaining permits and negotiating property rights would be a challenging multiyear process; and (3) obtaining easements and construction access would be vastly more difficult now because of the substantially higher value of coastal real estate. C1 [Morang, Andrew] HN CE Engn Res & Dev Ctr, Coastal & Hydraul Lab, Coastal Engn Branch, Vicksburg, MS 39180 USA. RP Morang, A (reprint author), HN CE Engn Res & Dev Ctr, Coastal & Hydraul Lab, Coastal Engn Branch, Vicksburg, MS 39180 USA. EM Andrew.Morang@usace.army.mil NR 84 TC 0 Z9 0 U1 4 U2 8 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 EI 1551-5036 J9 J COASTAL RES JI J. Coast. Res. PD JAN PY 2016 VL 32 IS 1 BP 181 EP 205 DI 10.2112/JCOASTRES-D-14-00074.1 PG 25 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA DB0UA UT WOS:000368221800015 ER PT J AU Wilber, DH Clarke, DG Alcoba, CM Gallo, J AF Wilber, Dara H. Clarke, Douglas G. Alcoba, Catherine M. Gallo, Jenine TI Windowpane flounder (Scophthalmus aquosus) and winter flounder (Pseudopleuronectes americanus) responses to cold temperature extremes in a Northwest Atlantic estuary SO JOURNAL OF SEA RESEARCH LA English DT Article; Proceedings Paper CT 9th International Flatfish Symposium (IFS) CY NOV, 2014 CL Cle Elum, WA DE New York/New Jersey Harbor; Flatfish; Overwintering; Thermal stress ID OF-THE-YEAR; PLAICE PLEURONECTES-PLATESSA; MOVEMENT PATTERNS; HABITAT QUALITY; SEA PLAICE; RECRUITMENT; GROWTH; LARVAL; MORTALITY; POPULATION AB The effect of climate variability on flatfish includes not only the effects of warming on sensitive life history stages, but also impacts from more frequent or unseasonal extreme cold temperatures. Cold weather events can affect the overwintering capabilities of flatfish near their low temperature range limits. We examined the responses of two flatfish species, the thin-bodied windowpane (Scophthalmus aquosus) and cold-tolerant winter flounder (Pseudopleuronectes americanus), to variable winter temperatures in a Northwest Atlantic estuary using abundance and size data collected during a monitoring study, the Aquatic Biological Survey, conducted from 2002 to 2010. Winter and spring abundances of small (50 to 120 mm total length) juvenile windowpane were positively correlated with adult densities (spawning stock) and fall temperatures (thermal conditions experienced during post-settlement development for the fall-spawned cohort) of the previous year. Windowpane abundances in the estuary were significantly reduced and the smallest size class was nearly absent after several consecutive years with cold (minimum temperatures <1 degrees C) winters. Interannual variation in winter flounder abundances was unrelated to the severity of winter temperatures. A Paulik diagram illustrates strong positive correlations between annual abundances of sequential winter flounder life history stages (egg, larval, Age-1 juvenile, and adult male) within the estuary, reflecting residency within the estuary through their first year of life. Temperature variables representing conditions during winter flounder larval and post-settlement development were not significant factors in multiple regression models exploring factors that affect juvenile abundances. Likewise, densities of predators known to consume winter flounder eggs and/or post-settlement juveniles were not significantly related to interannual variation in winter flounder juvenile abundances. Colder estuarine temperatures through the first year of life were associated with smaller Age-1 winter flounder body size. For example, Age-1 winter flounder developing under conditions that differed by 1.9 degrees C in mean daily water temperature, averaged 98.7 mm total length (TL) and 123.1 mm TL, for the relatively cold vs. moderate years, respectively. More frequent cold temperature extremes associated with climate variability may negatively impact the overwintering capabilities of some flatfish near their cold temperature range limits, whereas cold-tolerant species may experience reduced growth, which imparts the ecological challenges associated with smaller body size. (C) 2015 Elsevier B.V. All rights reserved. C1 [Wilber, Dara H.] HX5, Charleston, SC 29412 USA. [Clarke, Douglas G.] HDR Engn Inc, Mahwah, NJ 07495 USA. [Alcoba, Catherine M.; Gallo, Jenine] US Army, Corps Engineers New York Dist, New York, NY 10278 USA. RP Wilber, DH (reprint author), HX5, 664 Old Plantat Rd, Charleston, SC 29412 USA. EM darawilber@gmail.com NR 49 TC 0 Z9 0 U1 3 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1385-1101 EI 1873-1414 J9 J SEA RES JI J. Sea Res. PD JAN PY 2016 VL 107 SI SI BP 23 EP 30 DI 10.1016/j.seares.2015.04.005 PN 1 PG 8 WC Marine & Freshwater Biology; Oceanography SC Marine & Freshwater Biology; Oceanography GA DA8GP UT WOS:000368043400005 ER PT J AU Martin, RC Grier, T Canham-Chervak, M Anderson, MK Bushman, TT DeGroot, DW Jones, BH AF Martin, Robyn C. Grier, Tyson Canham-Chervak, Michelle Anderson, Morgan K. Bushman, Timothy T. DeGroot, David W. Jones, Bruce H. TI VALIDITY OF SELF-REPORTED PHYSICAL FITNESS AND BODY MASS INDEX IN A MILITARY POPULATION SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Article DE army; self-report; APFT; exercise; survey; recall ID ACTIVITY QUESTIONNAIRE; RISK-FACTORS; INJURIES; ARMY; WEIGHT; HEIGHT; REPRODUCIBILITY; RELIABILITY; HEALTH; UNIT AB Martin, RC, Grier, T, Canham-Chervak, M, Anderson, MK, Bushman, TT, DeGroot, DW, and Jones, BH. Validity of self-reported physical fitness and body mass index in a military population. J Strength Cond Res 30(1): 26-32, 2016Many epidemiological studies rely on valid physical fitness data. The purpose of this investigation was to assess the validity of self-reported Army Physical Fitness Test (APFT) data and determine whether men and women recall APFT performance differently. U.S. Army soldiers (N = 1,047) completed a survey, including questions on height, weight, and most recent APFT performance. Height, weight, and APFT performance were also obtained from unit records. The mean +/- SDs for unit and self-reported push-up repetitions were 63.5 +/- 13.1 and 66.3 +/- 14.0 for men and 37.7 +/- 12.8 and 40.2 +/- 12.8 for women, respectively. The mean +/- SD for unit- and self-reported sit-up repetitions were 66.3 +/- 11.4 and 68.1 +/- 12.1 for men and 64.2 +/- 13.6 and 66.5 +/- 12.9 for women, respectively. The mean +/- SD unit- and self-reported 2-mile run times were 15.2 +/- 1.8 and 14.9 +/- 1.6 minutes for men, and 18.0 +/- 2.9 and 17.4 +/- 1.9 minutes for women, respectively. Unit- and self-reported body mass indices (BMIs) (calculated by height and weight) were 26.4 +/- 3.4 and 26.3 +/- 3.6 for men and 24.6 +/- 2.8 and 24.2 +/- 3.3 for women. Correlations between unit- and self-reported scores for push-ups, sit-ups, 2-mile run, height, weight, and BMI were 0.82, 0.78, 0.85, 0.87, 0.97, and 0.88 for men and 0.86, 0.84, 0.87, 0.78, 0.98, and 0.78 for women, respectively. On average, men and women slightly overreported performance on the APFT and overestimated height, resulting in underestimated BMI. There was no difference in recall ability between men and women (p > 0.05). The very good to excellent correlations (r = 0.78-0.98) between unit- and self-reported scores indicate that self-reported data are valid for capturing physical fitness performance in this population. C1 [Martin, Robyn C.; Grier, Tyson; Canham-Chervak, Michelle; Anderson, Morgan K.; Bushman, Timothy T.; DeGroot, David W.; Jones, Bruce H.] US Army, Publ Hlth Command, Army Inst Publ Hlth, Injury Prevent Program, Aberdeen Proving Ground, MD 21005 USA. RP Grier, T (reprint author), US Army, Publ Hlth Command, Army Inst Publ Hlth, Injury Prevent Program, Aberdeen Proving Ground, MD 21005 USA. EM tyson.l.grier.civ@mail.mil NR 25 TC 2 Z9 2 U1 5 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1064-8011 EI 1533-4287 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD JAN PY 2016 VL 30 IS 1 BP 26 EP 32 DI 10.1519/JSC.0000000000001026 PG 7 WC Sport Sciences SC Sport Sciences GA DA4TC UT WOS:000367792600004 PM 26683633 ER PT J AU Tolisano, AM Justin, GA Ruhl, DS Cable, BB AF Tolisano, Anthony M. Justin, Grant A. Ruhl, Douglas S. Cable, Benjamin B. TI Rhinology and Medical Malpractice: An Update of the Medicolegal Landscape of the Last Ten Years SO LARYNGOSCOPE LA English DT Article DE Rhinology; malpractice; negligence ID ENDOSCOPIC SINUS SURGERY; LEGAL RESPONSIBILITY; SINONASAL DISEASE; LIABILITY; LITIGATION; OTOLARYNGOLOGY; NERVE; TRIALS; CANCER; INJURY AB Objectives/Hypothesis: Malpractice claims pertaining to rhinological procedures are a potentially important source of information that could be used to minimize the risk of future litigation and improve patient care. Study Design: A retrospective review of a publicly available database containing jury verdicts and settlements. Methods: The LexisNexis Jury Verdicts and Settlements database was reviewed for all lawsuits and out-of-court adjudications related to the practice of rhinology. Data including patient demographics, type of surgery performed, plaintiff allegation, nature of injury, outcomes, and indemnities were collected and analyzed. Results: Of 85 cases meeting inclusion criteria, 42 were decided by a jury and 43 were adjudicated out of court. Endoscopic sinus surgery was the most commonly litigated surgery. The plaintiff was favored when the eye was injured (P=0.0196), but the defendant was favored when neuropsychological injuries (P=0.0137) or recurrent/worsened symptoms (P=0.0050) were cited. No difference was found when death or skull base injuries occurred. When lack of informed consent was an allegation, the defendant was favored (P=0.0001). A payout was made in two-thirds of cases overall, but the defendant was favored in two-thirds of cases decided by a jury. Payments were significant for both out-of-court settlements ($ 1.3 million) and jury verdicts ($ 2 million). Conclusions: Endoscopic sinus surgery remains the most commonly litigated rhinology procedure and has the potential to result in large payouts. Meticulous dissection, recognition of complications, and documentation of informed consent remain paramount for providing optimal patient care. C1 [Tolisano, Anthony M.; Ruhl, Douglas S.; Cable, Benjamin B.] Tripler Army Med Ctr, Dept Otolaryngol, Honolulu, HI 96859 USA. [Justin, Grant A.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. RP Tolisano, AM (reprint author), Tripler Army Med Ctr, Dept Otolaryngol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM anthony.m.tolisano.mil@mail.mil NR 27 TC 2 Z9 2 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0023-852X EI 1531-4995 J9 LARYNGOSCOPE JI Laryngoscope PD JAN PY 2016 VL 126 IS 1 BP 14 EP 19 DI 10.1002/lary.25533 PG 6 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA DA9LT UT WOS:000368131000013 PM 26256664 ER PT J AU Tran, DT AF Tran, Dat T. TI Synthesis of porous ZnO based materials using an agarose gel template for H2S desulfurization SO RSC ADVANCES LA English DT Article ID HYDROGEN-SULFIDE ADSORPTION; TEMPERATURE DESULFURIZATION; MID-TEMPERATURE; GRAPHITE OXIDE; REMOVAL; BIOGAS; SIZE; CHEMISORPTION; PERFORMANCE; MORPHOLOGY AB This work describes the synthesis and characterization of pure ZnO and Ni-doped ZnO materials using agarose gel as a template for H2S desulfurization. H2S gas is not only harmful to the environment, but also corrosive to metals and poisonous to fuel reformer and fuel cell catalysts. Removal of H2S is an important step in fuel processing technology. This synthetic approach resulted in highly porous network ZnO based sorbent materials. The phase structure and morphology of these two materials were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Brunauer, Emmett and Teller (BET) surface area measurements, and mercury porosimetry. The H2S desulfurization performance of the as-synthesized ZnO and Ni-doped ZnO materials versus commercial ZnO was studied in a simulated fuel processing operation at 400 degrees C with an initial H2S concentration of 400 ppmv. It is shown that the sulfur adsorption capacity is greatly affected by the size and morphology of the particles. Desulfurization analysis revealed that commercial ZnO exhibits a low saturation capacity of 245 mg S per g while as-synthesized ZnO has a capacity of 457 mg S per g. Notably, when ZnO was doped with 4 wt% Ni, the sorbent capacity increased still further to 730 mg S per g. C1 [Tran, Dat T.] US Army, Res Lab, RDRL SED E, Adelphi, MD 20783 USA. RP Tran, DT (reprint author), US Army, Res Lab, RDRL SED E, Adelphi, MD 20783 USA. EM dat.t.tran4.civ@mail.mil NR 38 TC 2 Z9 2 U1 5 U2 33 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2046-2069 J9 RSC ADV JI RSC Adv. PY 2016 VL 6 IS 2 BP 1339 EP 1345 DI 10.1039/c5ra21383e PG 7 WC Chemistry, Multidisciplinary SC Chemistry GA DA6ZA UT WOS:000367953200059 ER PT J AU Hanrahan, B Sanchez, L Waits, CM Polcawich, RG AF Hanrahan, B. Sanchez, L. Waits, C. M. Polcawich, R. G. TI Improved pyroelectric performance for thin film lead zirconate titanate (PZT) capacitors with IrO2 electrodes SO SMART MATERIALS AND STRUCTURES LA English DT Article DE pyroelectric; energy harvesting; thin films ID LEAKAGE CURRENT; CONDUCTIVITY; CONVERSION; CERAMICS AB A four orders-of-magnitude reduction in high temperature leakage current was realized through the use of IrO2 top electrodes in thin film lead zirconate titanate capacitors which has been shown to directly impact the performance of future energy conversion applications. Pyroelectric energy conversion is enhanced near the material Curie temperature, but elevated leakage current in this temperature range hinders current applications. Conductivity experiments varying temperature, composition, and applied bias showed that oxygen vacancy hopping dominates the leakage current in the thin film capacitors above 200 degrees C. IrO2 top electrodes allow for a reduction in vacancy concentration by allowing for oxygen to be reintroduced during a post-processing annealing step for the thin film. The power lost to leakage current through the pyroelectric conversion cycle is explored. Improvements in remnant polarization and pyroelectric constant are also realized. C1 [Hanrahan, B.] Oak Ridge Associated Univ, US Army, Res Lab, Adelphi, MD 20783 USA. [Sanchez, L.] VerAvanti Inc, Redmond, WA 98052 USA. [Waits, C. M.; Polcawich, R. G.] US Army, Res Lab, Adelphi, MD 20783 USA. RP Hanrahan, B (reprint author), Oak Ridge Associated Univ, US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM brendan.m.hanrahan.civ@mail.mil NR 39 TC 0 Z9 0 U1 4 U2 7 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0964-1726 EI 1361-665X J9 SMART MATER STRUCT JI Smart Mater. Struct. PD JAN PY 2016 VL 25 IS 1 AR 015025 DI 10.1088/0964-1726/25/1/015025 PG 9 WC Instruments & Instrumentation; Materials Science, Multidisciplinary SC Instruments & Instrumentation; Materials Science GA DB0UJ UT WOS:000368222700030 ER PT J AU Pelled, G Sheyn, D Tawackoli, W Jun, DS Koh, Y Su, S Yakubovich, DC Kallai, I Ben Antebi, B Da, XY Gazit, Z Bae, H Gazit, D AF Pelled, Gadi Sheyn, Dmitriy Tawackoli, Wafa Jun, Deuk Soo Koh, Youngdo Su, Susan Yakubovich, Doron Cohn Kallai, Ilan Antebi, Ben Da, Xiaoyu Gazit, Zulma Bae, Hyun Gazit, Dan TI BMP6-Engineered MSCs Induce Vertebral Bone Repair in a Pig Model: A Pilot Study SO STEM CELLS INTERNATIONAL LA English DT Article ID MESENCHYMAL STEM-CELLS; MEDIATED GENE-THERAPY; TISSUE REGENERATION; RANDOMIZED-TRIAL; CANCELLOUS BONE; FRACTURES; DEFECT; SCAFFOLDS; DELIVERY; VERTEBROPLASTY AB Osteoporotic patients, incapacitated due to vertebral compression fractures (VCF), suffer grave financial and clinical burden. Current clinical treatments focus on symptoms' management but do not combat the issue at the source. In this pilot study, allogeneic, porcine mesenchymal stem cells, overexpressing the BMP6 gene (MSC-BMP6), were suspended in fibrin gel and implanted into a vertebral defect to investigate their effect on bone regeneration in a clinically relevant, large animal pig model. To check the effect of the BMP6-modified cells on bone regeneration, a fibrin gel only construct was used for comparison. Bone healing was evaluated in vivo at 6 and 12 weeks and ex vivo at 6 months. In vivo CT showed bone regeneration within 6 weeks of implantation in the MSC-BMP6 group while only minor bone formation was seen in the defect site of the control group. After 6 months, ex vivo analysis demonstrated enhanced bone regeneration in the BMP6-MSC group, as compared to control. This preclinical study presents an innovative, potentially minimally invasive, technique that can be used to induce bone regeneration using allogeneic gene modified MSCs and therefore revolutionize current treatment of challenging conditions, such as osteoporosis-related VCFs. C1 [Pelled, Gadi; Sheyn, Dmitriy; Tawackoli, Wafa; Jun, Deuk Soo; Koh, Youngdo; Su, Susan; Gazit, Zulma; Bae, Hyun; Gazit, Dan] Cedars Sinai Med Ctr, Dept Surg, Los Angeles, CA 90048 USA. [Pelled, Gadi; Sheyn, Dmitriy; Tawackoli, Wafa; Su, Susan; Gazit, Zulma; Gazit, Dan] Cedars Sinai Med Ctr, Board Governors Regenerat Med Inst, Los Angeles, CA 90048 USA. [Pelled, Gadi; Tawackoli, Wafa; Da, Xiaoyu] Cedars Sinai Med Ctr, Biomed Imaging Res Inst, Los Angeles, CA 90048 USA. [Pelled, Gadi; Yakubovich, Doron Cohn; Kallai, Ilan; Antebi, Ben; Gazit, Zulma; Gazit, Dan] Hebrew Univ Jerusalem, Hadassah Fac Dent Med, Skeletal Biotech Lab, Jerusalem, Israel. [Jun, Deuk Soo] Gachon Univ Med & Sci, Gil Med Ctr, Dept Orthopaed Surg, Inchon, South Korea. [Koh, Youngdo] EwhaWomans Univ, Sch Med, Dept Orthoped, Seoul, South Korea. [Antebi, Ben] US Army Inst Surg Res, San Antonio, TX 78234 USA. RP Gazit, D (reprint author), Cedars Sinai Med Ctr, Dept Surg, Los Angeles, CA 90048 USA. EM dan.gazit@csmc.edu OI Bae, Hyun/0000-0002-6386-344X FU NIH/National Center for Advancing Translational Science (NCATS) UCLA CTSI [UL1TR000124]; USAMRMC/TATRC [W81XWH-09-1-0644]; CIRM [DR2-05288] FX The research described was partially supported by NIH/National Center for Advancing Translational Science (NCATS) UCLA CTSI, Grant no. UL1TR000124, USAMRMC/TATRC, Grant no. W81XWH-09-1-0644, and CIRM, Grant no. DR2-05288. NR 53 TC 0 Z9 0 U1 1 U2 9 PU HINDAWI PUBLISHING CORP PI NEW YORK PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA SN 1687-966X EI 1687-9678 J9 STEM CELLS INT JI Stem Cells Int. PY 2016 AR 6530624 DI 10.1155/2016/6530624 PG 8 WC Cell & Tissue Engineering SC Cell Biology GA DB1WK UT WOS:000368299500001 ER PT J AU Cap, AP AF Cap, Andrew P. TI Platelet storage: a license to chill! SO TRANSFUSION LA English DT Editorial Material ID FROZEN-BLOOD PRODUCTS; TRANSFUSION; TRAUMA; 4-DEGREES-C; MILITARY; 22-C; 4-C C1 [Cap, Andrew P.] US Army, Inst Surg Res, Blood Res Program, San Antonio, TX 78234 USA. RP Cap, AP (reprint author), US Army, Inst Surg Res, Blood Res Program, San Antonio, TX 78234 USA. EM andrew.p.cap.mil@mail.mil NR 24 TC 7 Z9 7 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD JAN PY 2016 VL 56 IS 1 BP 13 EP 16 DI 10.1111/trf.13433 PG 4 WC Hematology SC Hematology GA DA6YJ UT WOS:000367951500001 PM 26756706 ER PT J AU Bhavsar, AK Gelner, EJ Shorma, T AF Bhavsar, Amit K. Gelner, Elizabeth J. Shorma, Toni TI Common Questions About the Evaluation of Acute Pelvic Pain SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID LOWER QUADRANT PAIN; ADNEXAL TORSION; ABDOMINAL-PAIN; INFLAMMATORY-DISEASE; COMPUTED-TOMOGRAPHY; ECTOPIC PREGNANCY; WOMEN; ULTRASOUND; DIAGNOSIS; AGE AB Acute pelvic pain is defined as lower abdominal or pelvic pain of less than three months' duration. It is a common presentation in primary care. Evaluation can be challenging because of a broad differential diagnosis and because many associated signs and symptoms are nonspecific. The most common diagnoses in reproductive-aged women with acute pelvic pain are idiopathic pelvic pain, pelvic inflammatory disease, acute appendicitis, ovarian cysts, ectopic pregnancy, and endometriosis. Among postmenopausal women, cancer must be considered. Findings from the history and physical examination can point to likely diagnoses, and laboratory testing and imaging can help confirm. Women of reproductive age should take a pregnancy test. In early pregnancy, transvaginal ultrasonography and beta human chorionic gonadotropin levels can help identify ectopic pregnancy and spontaneous abortion. For nonpregnant women, ultrasonography or computed tomography is indicated, depending on the possible diagnosis (e.g., ultrasonography is preferred when ovarian pathology is suspected). If ultrasonography results are nondiagnostic, magnetic resonance imaging can be helpful in pregnant women when acute appendicitis is suspected. If magnetic resonance imaging is unavailable, computed tomography may be indicated. Copyright (C) 2016 American Academy of Family Physicians. C1 [Bhavsar, Amit K.; Gelner, Elizabeth J.; Shorma, Toni] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Bhavsar, AK (reprint author), Tripler Army Med Ctr, 1 Jarret White Rd, Honolulu, HI 96859 USA. EM amit.k.bhavsar.mil@mail.mil NR 37 TC 0 Z9 0 U1 0 U2 6 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X EI 1532-0650 J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD JAN 1 PY 2016 VL 93 IS 1 BP 41 EP 48 PG 8 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA DA5SU UT WOS:000367863600006 PM 26760839 ER PT J AU Juliano, JJ Parobek, CM Brazeau, NF Ngasala, B Randrianarivelojosia, M Lou, C Mwandagalirwa, K Tshefu, A Dhar, R Das, BK Hoffman, I Martinson, F Martensson, A Saunders, DL Kumar, N Meshnick, SR AF Juliano, Jonathan J. Parobek, Christian M. Brazeau, Nicholas F. Ngasala, Billy Randrianarivelojosia, Milijaona Lou, Chanthap Mwandagalirwa, Kashamuka Tshefu, Antoinette Dhar, Ravi Das, Bidyut K. Hoffman, Irving Martinson, Francis Martensson, Andreas Saunders, David L. Kumar, Nirbhay Meshnick, Steven R. TI Pooled Amplicon Deep Sequencing of Candidate Plasmodium falciparum Transmission-Blocking Vaccine Antigens SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID MALARIA VACCINES; CONTROLLED-TRIAL; AFRICA; SAFETY; ADULTS AB Polymorphisms within Plasmodium falciparum vaccine candidate antigens have the potential to compromise vaccine efficacy. Understanding the allele frequencies of polymorphisms in critical binding regions of antigens can help in the designing of strain-transcendent vaccines. Here, we adopt a pooled deep-sequencing approach, originally designed to study P. falciparum drug resistance mutations, to study the diversity of two leading transmission-blocking vaccine candidates, Pfs25 and Pfs48/45. We sequenced 329 P. falciparum field isolates from six different geographic regions. Pfs25 showed little diversity, with only one known polymorphism identified in the region associated with binding of transmission-blocking antibodies among our isolates. However, we identified four new mutations among eight non-synonymous mutations within the presumed antibody-binding region of Pfs48145. Pooled deep sequencing provides a scalable and cost-effective approach for the targeted study of allele frequencies of P falciparum candidate vaccine antigens. C1 Univ N Carolina, Sch Med, Div Infect Dis, Chapel Hill, NC 27599 USA. Univ N Carolina, Sch Med, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USA. Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA. Univ N Carolina, Sch Med, Med, Chapel Hill, NC 27599 USA. Univ N Carolina, Sch Med, Philosophy Program, Chapel Hill, NC 27599 USA. Muhimbili Univ Hlth & Allied Sci, Dept Parasitol, Sch Publ Hlth, Dar Es Salaam, Tanzania. [Randrianarivelojosia, Milijaona] Inst Pasteur Madagascar, Dept Malariol, Antananarivo, Madagascar. [Lou, Chanthap; Saunders, David L.] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. [Mwandagalirwa, Kashamuka; Tshefu, Antoinette] Univ Kinshasa, Sch Publ Hlth, Kinshasa, DEM REP CONGO. NII, Dept Biotechnol, New Delhi, India. [Das, Bidyut K.] Sriram Chandra Bhanj SCB Med Coll, Dept Med, Odisha, India. [Martinson, Francis] Univ North Carolina Project, Lilongwe, Malawi. Karolinska Inst, Malaria Res, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden. Uppsala Univ, Int Maternal & Child Hlth Unit, Uppsala, Sweden. [Kumar, Nirbhay] Tulane Univ, Sch Publ Hlth & Trop Med, Dept Trop Med, New Orleans, LA USA. RP Juliano, JJ (reprint author), Univ N Carolina, Dept Med, Div Infect Dis, CB 7030,130 Mason Farm Rd, Chapel Hill, NC 27599 USA. EM jjuliano@med.unc.edu; christian_parobek@med.unc.edu; nbrazeau1@gmail.com; bngasala70@yahoo.co.uk; milijaon@pasteur.mg; chanthapl.ca@afrims.org; mkashamuka@yahoo.com; antotshe@yahoo.com; rdhar_in@yahoo.com; bidyutdas@hotmail.com; irving_hoffman@med.unc.edu; francis_martinson@med.unc.edu; andreas.martensson@ki.se; david.saunders@afrims.org; nkumar@tulane.edu; meshnick@email.unc.edu FU National Institute for Allergy and Infectious Diseases (NIAID) [R01AI089819, R21AI101427, R21 AI103466, R01AI107949]; National Institute of General Medicine Sciences [T32GM008719, T32GM007092, F30AI109979]; IDSA Medical Scholars Program; U.S. Department of Defense Global Emerging Surveillance Program; Swedish Development Cooperation Agency (SIDA) [Bil-Tz 16/9875007059]; Swedish Medical Research Council [2013-6594]; Institut Pasteur de Madagascar FX This project was funded by the National Institute for Allergy and Infectious Diseases (NIAID) grant R01AI089819 (JJJ), R21AI101427 (NK), R21 AI103466 (NK), and R01AI107949 (SRM). Christian M. Parobek was supported by the National Institute of General Medicine Sciences T32GM008719, T32GM007092, and F30AI109979. Nicholas F. Brazeau was funded by a grant from the IDSA Medical Scholars Program. David L. Saunders and Chanthap Lon were supported by the U.S. Department of Defense Global Emerging Surveillance Program. Billy Ngasala and Andreas Martensson were supported by The Swedish Development Cooperation Agency (SIDA) (Bil-Tz 16/9875007059). Andreas Martensson was also supported by The Swedish Medical Research Council (2013-6594). Sample collection in Sainte Marie was financially supported by Institut Pasteur de Madagascar. NR 16 TC 3 Z9 3 U1 2 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JAN PY 2016 VL 94 IS 1 BP 143 EP 146 DI 10.4269/ajtmh.15-0571 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA DA3NX UT WOS:000367705500025 PM 26503281 ER PT J AU Kuchuloria, T Imnadze, P Mamuchishvili, N Chokheli, M Tsertsvadze, T Endeladze, M Mshvidobadze, K Gatserelia, L Makhviladze, M Kanashvili, M Mikautadze, T Nanuashvili, A Kiknavelidze, K Kokaia, N Makharadze, M Clark, DV Bautista, CT Farrell, M Fadeel, MA Maksoud, MA Pimentel, G House, B Hepburn, MJ Rivard, RG AF Kuchuloria, Tinatin Imnadze, Paata Mamuchishvili, Nana Chokheli, Maiko Tsertsvadze, Tengiz Endeladze, Marina Mshvidobadze, Ketevan Gatserelia, Lana Makhviladze, Manana Kanashvili, Marine Mikautadze, Teona Nanuashvili, Alexander Kiknavelidze, Khatuni Kokaia, Nora Makharadze, Manana Clark, Danielle V. Bautista, Christian T. Farrell, Margaret Fadeel, Moustafa Abdel Maksoud, Mohamed Abdel Pimentel, Guillermo House, Brent Hepburn, Matthew J. Rivard, Robert G. TI Hospital-Based Surveillance for Infectious Etiologies among Patients with Acute Febrile Illness in Georgia, 2008-2011 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID HUMAN BRUCELLOSIS; HEMORRHAGIC-FEVER; TYPHOID-FEVER; COUNTRY; EPIDEMIOLOGY; DIAGNOSIS; EGYPT AB Information on the infectious causes of undifferentiated acute febrile illness (AFT) in Georgia is essential for effective treatment and prevention. In May 2008, a hospital-based AFI surveillance was initiated at six hospitals in Georgia. Patients aged >= 4 years with fever >= 38 degrees C for >= 48 hours were eligible for surveillance. Blood culture and serologic testing were conducted for Leptospira spp., Brucella spp., West Nile virus (WNV), Crimean-Congo hemorrhagic fever virus, Coxiella burnetii, tick-borne encephalitis virus (TBEV), hantavirus, Salmonella enterica serovar Typhi (S. Typhi), and Rickettsia typhi. Of 537 subjects enrolled, 70% were outpatients, 54% were males, and the mean age was 37 years. Patients reported having fatigue (89%), rigors (87%), sweating (83%), pain in joints (49%), and sleep disturbances (42%). Thirty-nine (7%) patients were seropositive for R. typhi, 37 (7%) for Brucella spp., 36 (7%) for TBEV, 12 (2%) for Leptospira spp., 10 (2%) for C. burnetii, and three (0.6%) for S. Typhi. None of the febrile patients tested positive for WNV antibodies. Of the patients, 73% were negative for all pathogens. Our results indicate that most of the targeted pathogens are present in Georgia, and highlight the importance of enhancing laboratory capacity for these infectious diseases. C1 [Kuchuloria, Tinatin; Imnadze, Paata; Tsertsvadze, Tengiz] Javakhishvili Tbilisi State Univ, Tbilisi 0179, Rep of Georgia. [Imnadze, Paata; Mamuchishvili, Nana; Chokheli, Maiko] Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia. [Tsertsvadze, Tengiz; Endeladze, Marina; Mshvidobadze, Ketevan; Gatserelia, Lana] Infect Dis AIDS & Clin Immunol Res Ctr, Tbilisi, Rep of Georgia. [Makhviladze, Manana; Kanashvili, Marine; Mikautadze, Teona] V Bochorishvili Sepsis Ctr, Tbilisi, Rep of Georgia. [Nanuashvili, Alexander; Kiknavelidze, Khatuni] Sachkhere Hosp, Sachkhere, Rep of Georgia. [Kokaia, Nora; Makharadze, Manana] S Virsaladze Res Inst Med Parasitol & Trop Med, Tbilisi, Rep of Georgia. [Clark, Danielle V.; Bautista, Christian T.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Farrell, Margaret; Fadeel, Moustafa Abdel; Maksoud, Mohamed Abdel; Pimentel, Guillermo; House, Brent] US Naval Med Res Unit 3, Global Dis Detect & Response Program, Cairo, Egypt. [Hepburn, Matthew J.; Rivard, Robert G.] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. RP Kuchuloria, T (reprint author), Javakhishvili Tbilisi State Univ, 1 Ilia Chavchavadze Ave, Tbilisi 0179, Rep of Georgia. EM drkuchuloria@yahoo.com; pimnadze@ncdc.ge; nanamamuchishvili@yahoo.com; chokhelimaiko@yahoo.com; aids@gol.ge; marinaendeladze@ymail.com; katemshvidobadze@yahoo.com; lgatserelia@yahoo.com; makhviladze_manana@yahoo.com; mkanashvili@mail.ru; mikautadze.teona@mail.ru; tamari.davitashvili@gmail.com; xatuna-kiknavelidze@rambler.ru; irma_kokaia@yahoo.com; mananamaxaradze@yahoo.com; dvclark@gmail.com; marcos.c.bautista.ctr@mail.mil; marleefar@gmail.com; moustafa.abdelfadeel.eg@med.navy.mil; mohamed.abdelmaksoud.eg@med.navy.mil; gpiment@gmail.com; brent.l.house2.mil@mail.mil; matthewhepburn@yahoo.com; robert.g.rivard.mil@mail.mil FU Global Emerging Infections Surveillance Program (GETS) FX This study was funded by the Global Emerging Infections Surveillance Program (GETS). NR 36 TC 0 Z9 0 U1 1 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JAN PY 2016 VL 94 IS 1 BP 236 EP 242 DI 10.4269/ajtmh.15-0400 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA DA3NX UT WOS:000367705500042 PM 26438032 ER PT J AU Tenan, MS Hackney, AC Griffin, L AF Tenan, Matthew S. Hackney, Anthony C. Griffin, Lisa TI Maximal force and tremor changes across the menstrual cycle SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE Menstrual cycle; Maximal force; Tremor Estrogen; Progesterone; Fatigue ID ADDUCTOR POLLICIS MUSCLE; CORTICAL EXCITABILITY; WOMEN; PERFORMANCE; PHASE; MOTOR; MEN; STRENGTH; ESTROGEN; BRAIN AB Sex hormones have profound effects on the nervous system in vitro and in vivo. The present study examines the effect of the menstrual cycle on maximal isometric force (MVC) and tremor during an endurance task. Nine eumenorrheic females participated in five study visits across their menstrual cycle. In each menstrual phase, an MVC and an endurance task to failure were performed. Tremor across the endurance task was quantified as the coefficient of variation in force and was assessed in absolute time and relative percent time to task failure. MVC decreases 23 % from ovulation to the mid luteal phase of the menstrual cycle. In absolute time, the mid luteal phase has the highest initial tremor, though the early follicular phase has substantially higher tremor than other phases after 150 s of task performance. In relative time, the mid luteal phase has the highest level of tremor throughout the endurance task. Both MVC and tremor during an endurance task are modified by the menstrual cycle. Performance of tasks and sports which require high force and steadiness to exhaustion may be decreased in the mid luteal phase compared to other menstrual phases. C1 [Tenan, Matthew S.] US Army Res Lab, RDRL HRS B, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. [Hackney, Anthony C.] Univ N Carolina, Dept Exercise & Sport Sci, Chapel Hill, NC 27599 USA. [Hackney, Anthony C.] Univ N Carolina, Sch Publ Hlth, Dept Nutr, Chapel Hill, NC 27599 USA. [Griffin, Lisa] Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA. RP Tenan, MS (reprint author), US Army Res Lab, RDRL HRS B, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. EM matthew.s.tenan.civ@mail.mil NR 38 TC 0 Z9 0 U1 0 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1439-6319 EI 1439-6327 J9 EUR J APPL PHYSIOL JI Eur. J. Appl. Physiol. PD JAN PY 2016 VL 116 IS 1 BP 153 EP 160 DI 10.1007/s00421-015-3258-x PG 8 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA DA2FH UT WOS:000367610200015 PM 26365403 ER PT J AU McDaniel, JS Pilia, M Raut, V Ledford, J Shiels, SM Wenke, JC Barnes, B Rathbone, CR AF McDaniel, Jennifer S. Pilia, Marcello Raut, Vivek Ledford, Jeffrey Shiels, Stefanie M. Wenke, Joseph C. Barnes, Brian Rathbone, Christopher R. TI Alternatives to autograft evaluated in a rabbit segmental bone defect SO INTERNATIONAL ORTHOPAEDICS LA English DT Article DE Rabbit; Bone marrow aspirate; Segmental defect; Tricalciumphosphate; Demineralised bone matrix ID MORPHOGENETIC PROTEINS; MARROW CONCENTRATE; STEM-CELLS; REPAIR; TISSUE; MODEL; FRACTURES; CAPACITY; MUSCLE; PUTTY AB Purpose This study was designed to identify strategies for treating bone defects that can be completed on the day of surgery. Methods Forty New Zealand white rabbits with unilateral rabbit radius segmental defects (15 mm) were treated with commercially available scaffolds containing either demineralised bone matrix (DBM) or a collagen/beta-tricalcium phosphate composite (Col:beta-TCP); each scaffold was combined with either bone marrow aspirate (BMA) or concentrated BMA (cBMA). Bone regeneration was assessed through radiographic and histological analyses. Results The concentration of nucleated cells, colony-forming unit-fibroblasts and platelets were increased and haematocrit concentration decreased in cBMA as compared to BMA (p<0.05). Radiographic analyses of bone formation and defect bridging demonstrated significantly greater bone regeneration in the defects treated with DBM grafts as compared to Col:beta-TCP grafts. The healing of bones treated with Col:beta-TCP was improved when augmented with cBMA. Conclusions Scaffolds containing either DBM or Col:beta-TCP with BMA or cBMA are effective same-day strategies available to clinicians for the treatment of bone defects; the latter scaffold may be more effective if combined with cBMA. C1 [McDaniel, Jennifer S.; Pilia, Marcello; Ledford, Jeffrey; Shiels, Stefanie M.; Wenke, Joseph C.; Rathbone, Christopher R.] US Army, Extrem Trauma & Regenerat Med, Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA. [Raut, Vivek; Barnes, Brian] Arteriocyte Med Syst, Hopkinton, MA USA. RP Rathbone, CR (reprint author), US Army, Extrem Trauma & Regenerat Med, Inst Surg Res, 3698 Chambers Pass BLDG 3611, Jbsa Ft Sam Houston, TX 78234 USA. EM chrisrathbone29@gmail.com OI Shiels, Stefanie/0000-0002-5904-3107 FU Armed Forces Institute of Regenerative Medicine; National Research Council FX The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or reflecting the views of the Department of the Army or Department of Defense. This study was supported in part by the Armed Forces Institute of Regenerative Medicine (BB). This research was supported in part by an appointment to the Student Research Participation Program at the US Army Institute of Surgical Research administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and USAMRMC (JM, SS) and the National Research Council (MP). We would like to thank Drs. Catherine Ward, Jessica Rivera and Randolph Stone for their invaluable contributions. NR 29 TC 0 Z9 0 U1 5 U2 11 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0341-2695 EI 1432-5195 J9 INT ORTHOP JI Int. Orthop. PD JAN PY 2016 VL 40 IS 1 BP 197 EP 203 DI 10.1007/s00264-015-2824-5 PG 7 WC Orthopedics SC Orthopedics GA DA4WR UT WOS:000367803400029 PM 26156711 ER PT J AU McGann, P Chahine, S Okafor, D Ong, AC Maybank, R Kwak, YI Wilson, K Zapor, M Lesho, E Hinkle, M AF McGann, Patrick Chahine, Sarah Okafor, Darius Ong, Ana C. Maybank, Rosslyn Kwak, Yoon I. Wilson, Kerry Zapor, Michael Lesho, Emil Hinkle, Mary TI Detecting 16S rRNA Methyltransferases in Enterobacteriaceae by Use of Arbekacin SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID GRAM-NEGATIVE BACTERIA; AMINOGLYCOSIDE RESISTANCE; PSEUDOMONAS-AERUGINOSA; NDM-1; RMTF; CARBAPENEMASE; PREVALENCE; INDIA; ARMA AB 16S rRNA methyltransferases confer resistance to most aminoglycosides, but discriminating their activity from that of aminoglycoside-modifying enzymes (AMEs) is challenging using phenotypic methods. We demonstrate that arbekacin, an aminoglycoside refractory to most AMEs, can rapidly detect 16S methyltransferase activity in Enterobacteriaceae with high specificity using the standard disk susceptibility test. C1 [McGann, Patrick; Chahine, Sarah; Okafor, Darius; Ong, Ana C.; Maybank, Rosslyn; Kwak, Yoon I.; Lesho, Emil; Hinkle, Mary] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA. [Wilson, Kerry] Walter Reed Natl Mil Med Ctr, Infect Dis Serv, Bethesda, MD USA. [Zapor, Michael] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD USA. RP McGann, P (reprint author), Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA. EM patrick.t.mcgann4.ctr@mail.mil FU U.S. Army Medical Command; Global Emerging Infections Surveillance and Response System; Defense Medical Research and Development Program FX This study was funded by the U.S. Army Medical Command, the Global Emerging Infections Surveillance and Response System, and the Defense Medical Research and Development Program. NR 22 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JAN PY 2016 VL 54 IS 1 BP 208 EP 211 DI 10.1128/JCM.02642-15 PG 4 WC Microbiology SC Microbiology GA DA1DX UT WOS:000367537600039 PM 26537447 ER PT J AU Fox, WP Ormond, B Williams, A AF Fox, William P. Ormond, Brendan Williams, Alex TI Ranking terrorist targets using a hybrid AHP-TOPSIS methodology SO JOURNAL OF DEFENSE MODELING AND SIMULATION-APPLICATIONS METHODOLOGY TECHNOLOGY-JDMS LA English DT Article DE Ranking terrorist targets; technique of order preference by similarity to ideal solution; analytical hierarchy process; criteria weights; pairwise comparisons; sensitivity analysis ID ANALYTIC HIERARCHY PROCESS; ATTRIBUTE DECISION-MAKING; PERFORMANCE-MEASUREMENT; ROBOT SELECTION; SENSITIVITY; MODELS AB We present a methodology and an example of preparing an order of merit list to rank terrorist targets based upon decision-maker weights. We used an old terrorist data set as our base data to keep the information unclassified. This data is used to demonstrate this methodology. We perform numerical iterative criteria weight sensitivity analysis to show the effects on the model's outputs in changes in the weights. We identify the critical criterion. C1 [Fox, William P.] Naval Postgrad Sch, Dept Def Anal, Monterey, CA 93943 USA. [Ormond, Brendan; Williams, Alex] US Army, Special Forces, San Antonio, TX USA. RP Fox, WP (reprint author), Naval Postgrad Sch, Dept Def Anal, 589 Dyer Rd,Room 103 F, Monterey, CA 93943 USA. EM wpfox@nps.edu NR 35 TC 0 Z9 0 U1 3 U2 3 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1548-5129 EI 1557-380X J9 J DEF MODEL SIMUL-AP JI J. Def. Model. Simul.-Appl. Methodol. Technol.-JDMS PD JAN PY 2016 VL 13 IS 1 BP 77 EP 93 DI 10.1177/1548512914563619 PG 17 WC Engineering, Multidisciplinary SC Engineering GA DA5IF UT WOS:000367836000007 ER PT J AU Bastian, ND Fulton, LV Griffin, PM Sung, YS Kumara, S AF Bastian, Nathaniel D. Fulton, Lawrence V. Griffin, Paul M. Sung, Yi-Shan Kumara, Soundar TI A casualty network analysis in non-major combat operations SO JOURNAL OF DEFENSE MODELING AND SIMULATION-APPLICATIONS METHODOLOGY TECHNOLOGY-JDMS LA English DT Article DE Complex networks; graph mining; network visualization; pattern recognition; military casualties; non-major combat operations AB Understanding the causes, types and locations of military casualties likely to be incurred during non-major combat operations is essential to effectively plan for medical resources required to support those operations, yet the threats posed are varied and complex. The dynamic environment that sustains non-major combat operations creates a challenge to diagnose the factors leading to casualties in these operations. We employ a network analytic approach to discover and explore the underlying casualty incident patterns in this complex, real-world operating environment. The aim of this study is to better understand the medical effect of health and irregular general threats. Discovery of these casualty incident patterns proves insightful to military medical planners and commanders. C1 [Bastian, Nathaniel D.; Sung, Yi-Shan; Kumara, Soundar] Penn State Univ, Dept Ind & Mfg Engn, Ctr Integrated Healthcare Delivery Syst, University Pk, PA 16802 USA. [Bastian, Nathaniel D.] US Mil Acad, Network Sci Ctr, Dept Math Sci, West Point, NY 10996 USA. [Bastian, Nathaniel D.; Fulton, Lawrence V.] Texas Tech Univ, Rawls Coll Business Adm, Ctr Healthcare Innovat Educ & Res, Lubbock, TX 79409 USA. [Bastian, Nathaniel D.; Griffin, Paul M.] Georgia Inst Technol, Ctr Hlth & Humanitarian Syst, H Milton Stewart Sch Ind & Syst Engn, Atlanta, GA 30332 USA. RP Bastian, ND (reprint author), Penn State Univ, Dept Ind & Mfg Engn, Ctr Integrated Healthcare Delivery Syst, 355 Leonhard Bldg, University Pk, PA 16802 USA. EM ndbastian@psu.edu NR 28 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1548-5129 EI 1557-380X J9 J DEF MODEL SIMUL-AP JI J. Def. Model. Simul.-Appl. Methodol. Technol.-JDMS PD JAN PY 2016 VL 13 IS 1 BP 95 EP 108 DI 10.1177/1548512915585885 PG 14 WC Engineering, Multidisciplinary SC Engineering GA DA5IF UT WOS:000367836000008 ER PT J AU Jackson, SJT Singletary, KW Murphy, LL Venema, RC Young, AJ AF Jackson, Steven J. T. Singletary, Keith W. Murphy, Laura L. Venema, Richard C. Young, Andrew J. TI Phytonutrients Differentially Stimulate NAD(P)H: Quinone Oxidoreductase, Inhibit Proliferation, and Trigger Mitotic Catastrophe in Hepa1c1c7 Cells SO JOURNAL OF MEDICINAL FOOD LA English DT Article DE cell cycle; curcumin; quercetin; resveratrol; sulforaphane ID JET FUEL; MICROTUBULE POLYMERIZATION; TUBULIN POLYMERIZATION; FOOD PHYTOCHEMICALS; ENDOTHELIAL-CELLS; CLINICAL-TRIAL; SULFORAPHANE; NRF2; PROGRESSION; PROTECTION AB Phytonutrients have rapidly emerged as natural food chemicals possessing multifaceted biological actions that may support beneficial health outcomes. Among the vast array of phytonutrients currently being studied, sulforaphane, curcumin, quercetin, and resveratrol have been frequently reported to stimulate the expression of endogenous detoxification enzymes and may thereby facilitate the neutralization of otherwise harmful environmental agents. Some of these same phytonutrients, however, have also been implicated in disrupting normal cell proliferation and hence may possess toxic properties in and of themselves. In this study, we characterize the respective minimum threshold concentrations of the aforementioned phytonutrients in Hepa1c1c7 cells that stimulate NAD(P)H:quinone oxidoreductase (NQO1), a key enzyme in the hepatic neutralization of menadione, other biological oxidants, and some environmental carcinogens. Moreover, our findings demonstrate that relatively low concentrations of either sulforaphane or curcumin significantly (P<.05) increase NQO1 protein expression and activity without triggering G(2)/M cell cycle arrest or mitotic catastrophe. The minimal quercetin concentration inducing NQO1, however, was 100-fold higher than that which disrupted mitosis. Also, while resveratrol modestly stimulated NQO1, the minimally effective resveratrol concentration concomitantly induced evidence of cellular apoptosis. Taken together, these findings indicate that only particular phytonutrients are likely efficacious in upregulating NQO1 activity without also leading to hepatic cytotoxicity. C1 [Jackson, Steven J. T.] US Army, Aeromed Res Lab, Aircrew Hlth & Performance Div, Fort Rucker, AL USA. [Singletary, Keith W.] Univ Illinois, Dept Food Sci & Human Nutr, Urbana, IL 61801 USA. [Murphy, Laura L.] So Illinois Univ, Dept Physiol, Carbondale, IL USA. [Venema, Richard C.] Georgia Regents Univ, Med Coll Georgia, Vasc Biol Ctr, Augusta, GA USA. [Young, Andrew J.] US Army, Environm Med Res Inst, Mil Nutr Div, Natick, MA USA. RP Jackson, SJT (reprint author), Archer Daniels Midland Co, 4666 Faries Pkwy, Decatur, GA 62526 USA. EM steven.jackson@adm.com FU U.S. Army Medical Research and Materiel Command, In-house Laboratory Independent Research Program (ILIR) FX This study was supported by the U.S. Army Medical Research and Materiel Command, In-house Laboratory Independent Research Program (ILIR). NR 41 TC 1 Z9 1 U1 4 U2 4 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1096-620X EI 1557-7600 J9 J MED FOOD JI J. Med. Food PD JAN 1 PY 2016 VL 19 IS 1 BP 47 EP 53 DI 10.1089/jmf.2015.0079 PG 7 WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition & Dietetics GA DA5EF UT WOS:000367824700006 PM 26623679 ER PT J AU Keller, CB Bielakowski, R AF Keller, Christian B. Bielakowski, Rae TI Hungarian Emigres in the American Civil War: A History and Biographical Dictionary SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Keller, Christian B.] US Army War Coll, Carlisle, PA 17013 USA. RP Keller, CB (reprint author), US Army War Coll, Carlisle, PA 17013 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD JAN PY 2016 VL 80 IS 1 BP 208 EP 211 PG 4 WC History SC History GA DA3NB UT WOS:000367703300020 ER PT J AU Barbuto, RV AF Barbuto, Richard V. TI Shays's Rebellion: Authority and Distress in Post-Revolutionary America SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Barbuto, Richard V.] US Army, Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. RP Barbuto, RV (reprint author), US Army, Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 2 U2 2 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD JAN PY 2016 VL 80 IS 1 BP 236 EP 237 PG 2 WC History SC History GA DA3NB UT WOS:000367703300036 ER PT J AU Marzoli, NA AF Marzoli, Nathan A. TI The First Battle for Petersburg: The Attack and Defense of the Cockade City, June 9, 1864. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Marzoli, Nathan A.] US Army, Ctr Mil Hist, Washington, DC 20024 USA. RP Marzoli, NA (reprint author), US Army, Ctr Mil Hist, Washington, DC 20024 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD JAN PY 2016 VL 80 IS 1 BP 244 EP 245 PG 2 WC History SC History GA DA3NB UT WOS:000367703300042 ER PT J AU Bjorge, GJ AF Bjorge, Gary J. TI Where Chiang Kai-shek Lost China: The Liao-Shen Campaign. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Bjorge, Gary J.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. RP Bjorge, GJ (reprint author), US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD JAN PY 2016 VL 80 IS 1 BP 295 EP 296 PG 2 WC History SC History GA DA3NB UT WOS:000367703300076 ER PT J AU Schneider, BA AF Schneider, Brent A. TI Cost-Effective Solutions to Mental Health Barriers Attributable to Budgetary and Qualified Personnel Inefficiencies SO JOURNAL OF NERVOUS AND MENTAL DISEASE LA English DT Letter C1 [Schneider, Brent A.] US Army, Universal City, TX USA. RP Schneider, BA (reprint author), US Army, Universal City, TX USA. EM brentschneider@g.harvard.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0022-3018 EI 1539-736X J9 J NERV MENT DIS JI J. Nerv. Ment. Dis. PD JAN PY 2016 VL 204 IS 1 BP 68 EP 68 DI 10.1097/NMD.0000000000000410 PG 1 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA DA5DR UT WOS:000367823100016 PM 26704467 ER PT J AU Sondeen, JL Hanson, MA Prince, MD de Guzman, R Polykratis, IA Aden, JK Cap, AP Dubick, MA AF Sondeen, Jill L. Hanson, Margaret A. Prince, Malcolm D. de Guzman, Rodolfo Polykratis, Irene A. Aden, James K. Cap, Andrew P. Dubick, Michael A. TI Double-blinded, placebo-controlled study of early tranexamic acid treatment in swine uncontrolled hemorrhage model SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Hemorrhagic shock; swine; tranexamic acid; combat casualty care; plasma ID TRAUMA PATIENTS; CONTROLLED-TRIAL; KNOWLEDGE GAPS; RESUSCITATION; TRANSFUSION; ACTIVATION; MORTALITY; PROMMTT; CRASH-2; IMPACT AB BACKGROUND Tranexamic acid (TXA) is an antifibrinolytic drug that was shown to increase survival in trauma patients, but the mechanisms remain unclear. The purpose of this double-blinded, randomized placebo-controlled study was to determine if TXA with hypotensive resuscitation with Hextend (HEX) or fresh frozen plasma (FFP) reduced blood loss (BL) and improved survival in a model of uncontrolled hemorrhage. METHODS Instrumented, anesthetized pigs (n = 11 per group) were subjected to 24-mL/kg controlled hemorrhage, followed by transection of the spleen. After 15 minutes of bleeding, TXA (1.43 mg/kg/min) or normal saline (NS) was given over 10 minutes, and then 15-mL/kg HEX or FFP was administered. At 90 minutes, a second infusion of TXA or NS was given. BL, coagulation status, and 5-hour survival were determined. Tissue plasminogen activator (tPA) was added to blood samples collected before and after TXA administration to confirm that the TXA inhibited fibrinolysis. In addition, a comparison of a dose response to tPA-induced fibrinolysis was made between swine and human plasma in vitro. RESULTS TXA prevented the rise in d-dimers that occurred after spleen injury. However, there was no significant effect of TXA on survival or BL compared with NS with HEX (HEX + NS, 17 2 mL/kg vs. HEX + TXA, 17 +/- 2 mL/kg) or FFP (FFP + NS, 7 +/- 2 mL/kg vs. FFP + TXA, 12 +/- 3 mL/kg), while FFP significantly reduced BL and increased survival compared with HEX in the NS-treated animals. The tPA-induced fibrinolysis was inhibited in the blood from TXA-treated animals, yet in fibrinolysis sensitivity studies, human plasma was 30 times more sensitive to tPA-induced fibrinolysis than swine plasma. CONCLUSION TXA did not reduce BL, even though TXA was antifibrinolytic in the pigs. The possibility remains that the pig is highly resistant to fibrinolysis and not a good model to study the effects of antifibrinolytics or that fibrinolysis is not a major factor in bleeding from splenic injury. C1 [Sondeen, Jill L.; Hanson, Margaret A.; Prince, Malcolm D.; de Guzman, Rodolfo; Polykratis, Irene A.; Aden, James K.; Cap, Andrew P.; Dubick, Michael A.] US Army Inst Surg Res, San Antonio, TX 78234 USA. RP Dubick, MA (reprint author), US Army Inst Surg Res, San Antonio, TX 78234 USA. EM Michael.a.dubick.civ@mail.mil NR 24 TC 1 Z9 1 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD JAN PY 2016 VL 80 IS 1 BP 81 EP 88 DI 10.1097/TA.0000000000000860 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA DA1GN UT WOS:000367544400012 PM 26683393 ER PT J AU Ramakrishnan, S Wesensten, NJ Balkin, TJ Reifman, J AF Ramakrishnan, Sridhar Wesensten, Nancy J. Balkin, Thomas J. Reifman, Jaques TI A Unified Model of Performance: Validation of its Predictions across Different Sleep/Wake Schedules SO SLEEP LA English DT Article DE biomathematical model; chronic sleep restriction; naps; PVT; total sleep deprivation; two-process model ID MATHEMATICAL-MODEL; NEUROBEHAVIORAL PERFORMANCE; DOSE-RESPONSE; RESTRICTION; DEPRIVATION; FATIGUE; SLEEPINESS; VIGILANCE; RECOVERY; VULNERABILITY AB Study Objectives: Historically, mathematical models of human neurobehavioral performance developed on data from one sleep study were limited to predicting performance in similar studies, restricting their practical utility. We recently developed a unified model of performance (UMP) to predict the effects of the continuum of sleep loss-from chronic sleep restriction (CSR) to total sleep deprivation (TSD) challenges-and validated it using data from two studies of one laboratory. Here, we significantly extended this effort by validating the UMP predictions across a wide range of sleep/wake schedules from different studies and laboratories. Methods: We developed the UMP on psychomotor vigilance task (PVT) lapse data from one study encompassing four different CSR conditions (7 d of 3, 5, 7, and 9 h of sleep/night), and predicted performance in five other studies (from four laboratories), including different combinations of TSD (40 to 88 h), CSR (2 to 6 h of sleep/night), control (8 to 10 h of sleep/night), and nap (nocturnal and diurnal) schedules. Results: The UMP accurately predicted PVT performance trends across 14 different sleep/wake conditions, yielding average prediction errors between 7% and 36%, with the predictions lying within 2 standard errors of the measured data 87% of the time. In addition, the UMP accurately predicted performance impairment (average error of 15%) for schedules (TSD and naps) not used in model development. Conclusions: The unified model of performance can be used as a tool to help design sleep/wake schedules to optimize the extent and duration of neurobehavioral performance and to accelerate recovery after sleep loss. C1 [Ramakrishnan, Sridhar; Reifman, Jaques] US Army Med Res & Mat Command, Dept Def, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. [Wesensten, Nancy J.; Balkin, Thomas J.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD USA. RP Reifman, J (reprint author), US Army Med Res & Mat Command, Dept Def, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr,ATTN MCMR TT, 504 Scott St, Ft Detrick, MD 21702 USA. EM jaques.reifman.civ@mail.mil FU Military Operational Medicine Research Area Directorate of the U.S. Army Medical Research and Materiel Command, Ft. Detrick, MD; US Department of Defense Medical Research and Development Program [DMRDP_13200] FX This was not an industry supported study. This work was sponsored by the Military Operational Medicine Research Area Directorate of the U.S. Army Medical Research and Materiel Command, Ft. Detrick, MD, and by the US Department of Defense Medical Research and Development Program (Grant No. DMRDP_13200). The authors have indicated no financial conflicts of interest. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or of the U.S. Department of Defense. This paper has been approved for public release with unlimited distribution. NR 34 TC 2 Z9 2 U1 2 U2 3 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 EI 1550-9109 J9 SLEEP JI Sleep PD JAN 1 PY 2016 VL 39 IS 1 BP 249 EP 262 DI 10.5665/sleep.5358 PG 14 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA DA0VM UT WOS:000367515700031 PM 26518594 ER PT J AU Gandhi, RT Bosch, RJ Rangsin, R Chuenchitra, T Sirisopana, N Kim, JH Robb, ML Vejbaesya, S Paris, RM Nelson, KE AF Gandhi, Rajesh T. Bosch, Ronald J. Rangsin, Ram Chuenchitra, Thippawan Sirisopana, Narongrid Kim, Jerome H. Robb, Merlin L. Vejbaesya, Sasijit Paris, Robert M. Nelson, Kenrad E. TI HLA Class I Alleles Associated with Mortality in Thai Military Recruits with HIV-1 CRF01_AE Infection SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID YOUNG MEN; NATURAL-HISTORY; AIDS; SEROCONVERSION; TRANSMISSION; PROGRESSION; FREQUENCY; DRB1; KIR AB In HIV-1-infected patients, variation at the HLA class I locus is associated with disease progression, but few studies have assessed the influence of HLA alleles on HIV-1 CRF01_AE infection, which is dominant in Thailand. We hypothesized that alleles predicted to confer more effective immune responses, such as HLA-B*46, would protect against disease progression. HLA typing was performed on HIV-1 incident cases surviving until 1998-1999 and HIV-1-negative matched controls from Thai army cohorts enrolled between 1991 and 1995. We assessed associations between class I alleles and disease progression subsequent to HLA typing. Ninety-nine HIV-1-incident cases were followed for a median of 3.7 years after HLA typing; during this time, 58 participants died. Two alleles were associated with mortality: HLA B*51 was protective (3-year survival B*51(pos) vs. B*51(neg): 75% vs. 52%; p=0.034) whereas Cw*04 was deleterious (3-year survival Cw*04(pos) vs. Cw*04(neg): 39% vs. 60%; p=0.027). HLA-B*46 was not associated with disease progression. Alleles present at different frequencies in HIV-1-incident compared with HIV-1-negative men included HLA-A*02:03, B*35, B*15, and C*08. 1. In conclusion in this Thai army cohort, HLA-B*51 was associated with lower mortality, confirming that this allele, which is protective in clade B HIV-1 infection, has a similar effect on HIV CRF01_AE infection. The deleterious effect of HLA-Cw*04 must be interpreted with caution because it may be in linkage disequilibrium with disease-susceptible HLA-B alleles. We did not find that HLA-B*46 was protective. These findings may inform vaccine development for areas of the world in which HIV-1 CRF01_AE infection is prevalent. C1 [Gandhi, Rajesh T.] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA. [Gandhi, Rajesh T.] MIT & Harvard, Massachusetts Gen Hosp, Ragon Inst, Cambridge, MA USA. [Bosch, Ronald J.] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA. [Rangsin, Ram] Phramongkutklao Coll Med, Dept Mil & Community Med, Bangkok, Thailand. [Chuenchitra, Thippawan; Sirisopana, Narongrid] AFRIMS, Div Res, Royal Thai Army, Bangkok, Thailand. [Kim, Jerome H.; Robb, Merlin L.] Int Vaccine Inst, Seoul, South Korea. [Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Vejbaesya, Sasijit] Siriraj Hosp, Dept Transfus Med, Fac Med, Bangkok, Thailand. [Paris, Robert M.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Paris, Robert M.] Walter Reed Army Inst Res, Mil Malaria Res Program, Silver Spring, MD USA. [Nelson, Kenrad E.] Johns Hopkins Univ, Dept Epidemiol, Bloomberg Sch Publ Hlth, Baltimore, MD USA. RP Gandhi, RT (reprint author), Massachusetts Gen Hosp, GRJ 504,55 Fruit St, Boston, MA 02114 USA. EM rgandhi@mgh.harvard.edu FU Henry M. Jackson Foundation for the Advancement of Military Medicine [W81XWH-07-2-0067]; U.S. Department of Defense [W81XWH-07-2-0067]; National Institutes of Health [NIAID 5P30AI060354-08] FX This work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the U.S. Department of Defense, and by the National Institutes of Health-funded Harvard University Center for AIDS Research (NIAID 5P30AI060354-08). The opinions or assertions contained herein are the private views of the authors, and are not to be construed as official, or as reflecting true views or positions of the United States Army or the Department of Defense. We would like to thank Neha Patel for her assistance in preparing this manuscript. We would like to express our appreciation for reviewer comments that strengthened the manuscript. NR 24 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD JAN 1 PY 2016 VL 32 IS 1 BP 44 EP 49 DI 10.1089/aid.2015.0120 PG 6 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA CZ8FH UT WOS:000367335100007 PM 26383907 ER PT J AU Atwood, CA Goebbert, RC Calahan, JA Hromadka, TV Proue, TM Monceaux, W Hirata, J AF Atwood, Christopher A. Goebbert, Randy C. Calahan, Joshua A. Hromadka, Theodore V., III Proue, Thomas M. Monceaux, Weston Hirata, Jason TI Secure Web-Based Access for Productive Supercomputing SO COMPUTING IN SCIENCE & ENGINEERING LA English DT Article AB US Department of Defense High Performance Computing Modernization Program communities are increasingly in need of access to highly capable computing, networking, storage, and software resources from their user enclaves that are administratively prevented from installation of applications due to malicious software risks. The HPC Portal enables a productive and secure computational science environment. C1 [Atwood, Christopher A.] US Dept Def, High Performance Comp Modernizat Program, Washington, DC 20301 USA. [Goebbert, Randy C.] Integr Applicat Inc, HPC Portal Dev Team, Chantilly, VA USA. [Calahan, Joshua A.] Arctic Slope Reg Corp ASRC Fed InuTeq, Barrow, AK USA. [Hromadka, Theodore V., III] Integr Applicat Inc, HPC Portal Project, Chantilly, VA USA. [Monceaux, Weston] US Army Corps Engineers, Engineer Res Dev Ctr, Informat Technol Lab, Washington, DC USA. [Hirata, Jason] Integr Applicat Inc, HPC Portal Project, Pacific Def Solut, Chantilly, VA USA. RP Atwood, CA (reprint author), US Dept Def, High Performance Comp Modernizat Program, Washington, DC 20301 USA. EM chris.atwood@hpc.mil; rgoebbert@integrity-apps.com; joshua.calahan.ctr@hpc.mil; thromadka@integrity-apps.com; tom.proue.ctr@dren.hpc.mil; weston.p.monceaux@usace.army.mil; jhirata@integrity-apps.com FU Department of Defense High Performance Computing Modernization Program (HPCMP) FX We thank the Department of Defense High Performance Computing Modernization Program (HPCMP) for funding the HPC Portal effort; we also thank the Maui High Performance Computing Center (MHPCC), Engineer Research and Development Center (ERDC), and HPCMP CREATE for development team hosting and collaboration. NR 9 TC 1 Z9 1 U1 0 U2 0 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1521-9615 EI 1558-366X J9 COMPUT SCI ENG JI Comput. Sci. Eng. PD JAN-FEB PY 2016 VL 18 IS 1 BP 63 EP 72 PG 10 WC Computer Science, Interdisciplinary Applications SC Computer Science GA CZ7DS UT WOS:000367260700007 ER PT J AU Wouters, N Serafim, MP Valayer, PJ Kirkup, BC Wang, YJ Cabral, HN AF Wouters, N. Serafim, M. P. Valayer, P. J. Kirkup, B. C. Wang, Y. J. Cabral, H. N. TI Early warning signals as indicators of cyclostationarity in three-species hierarchies SO ECOLOGICAL INDICATORS LA English DT Article DE Automaton; Patchiness; Early warning signal; Stability; Cyclic; Autocorrelation; Standard deviation ID ROCK-PAPER-SCISSORS; CRITICAL SLOWING-DOWN; ANTIBIOTIC PRODUCTION; COMPETITIVE NETWORKS; POPULATION COLLAPSE; TIPPING POINTS; ECOSYSTEMS; DYNAMICS; CLIMATE; SHIFTS AB Predicting stability from current ecosystem performance is theoretically difficult, but early statistical warning signals (EWS) may enable the anticipation of regime shifts. However, little is known regarding the behavior of EWS in shifts with cyclic dynamics. In this study, we use indicators to assess the stability of a three-species system in a competitive loop similar to a rock-paper-scissors (RPS) hierarchy. In two scenarios, the RPS is simulated using a 3-D automaton whose input matrix combines probabilities of pair-wise dominance with differential reaction frequencies. The first scenario uses the data of a microbial experiment in which the RPS hierarchy is characterized by incomplete dominance within species pairs and differences in reaction frequency between species pairs. The input of the second model was chosen to generate a contrasting scenario: a symmetric RPS interaction gradually subjected to a stressor. The reaction frequency of one species pair was modeled to decay linearly over time. The relative species abundances are monitored spatiotemporally. In the first scenario, abundances oscillate stably despite initial large swings, whereas in the second scenario, one species gradually dominates, eventually resulting in transitivity. In both scenarios, species cluster spatially in patches of single species. In scenario I, the average patch size remains constant throughout the iterations and possibly contributes to the overall stability; however, in the second scenario, a further homogenization takes place. In the first scenario, EWS reflected the system's stability with species abundances settling into a stable basin. In scenario I only one of the EWS indicators detected consistently the loss of resilience. Sensitivity analysis revealed excessive variability in dominance resulted in immediate loss of the RPS hierarchy. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Wouters, N.; Serafim, M. P.; Cabral, H. N.] Univ Lisboa Campo Grande, MARE Marine & Environm Sci Ctr, Fac Ciencias, P-1749016 Lisbon, Portugal. [Wouters, N.; Valayer, P. J.] Biomim Greenloop, B-1000 Brussels, Belgium. [Kirkup, B. C.] MIT, Dept Civil & Environm Engn, Boston, MA 02139 USA. [Kirkup, B. C.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Kirkup, B. C.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Wang, Y. J.] Rutgers State Univ, Dept Math Sci, Camden, NJ 08102 USA. [Wouters, N.; Serafim, M. P.; Cabral, H. N.] Univ Lisbon, Dept Biol Anim, Fac Ciencias, P-1749016 Lisbon, Portugal. RP Wouters, N (reprint author), Univ Lisboa Campo Grande, MARE Marine & Environm Sci Ctr, Fac Ciencias, P-1749016 Lisbon, Portugal. EM nwouters@fc.ul.pt RI Cabral, Henrique/D-5201-2011; Kirkup, Benjamin/C-3610-2009 OI Cabral, Henrique/0000-0002-7646-6208; Kirkup, Benjamin/0000-0002-8722-6218 FU Fundacao para a Ciencia e a Tecnologia [BD/48402/2008] FX The first author was funded by a PhD fellowship of Fundacao para a Ciencia e a Tecnologia with reference number BD/48402/2008. NR 46 TC 2 Z9 2 U1 2 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1470-160X EI 1872-7034 J9 ECOL INDIC JI Ecol. Indic. PD JAN PY 2016 VL 60 BP 586 EP 593 DI 10.1016/j.ecolind.2015.06.038 PG 8 WC Biodiversity Conservation; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA CZ9GW UT WOS:000367407000060 ER PT J AU Pearlstine, L Lo Galbo, A Reynolds, G Parsons, JH Dean, T Alvarado, M Suir, K AF Pearlstine, Leonard Lo Galbo, Alicia Reynolds, Gregg Parsons, Janice Holly Dean, Tylan Alvarado, Mario Suir, Kevin TI Recurrence intervals of spatially simulated hydrologic metrics for restoration of Cape Sable seaside sparrow (Ammodramus maritimus mirabilis) habitat SO ECOLOGICAL INDICATORS LA English DT Article DE Cape Sable seaside sparrow; Ammodramus maritimus mirabilis; Florida; Everglades; Marl prairie; Habitat model; Hydrologic suitability ID VEGETATION; MANAGEMENT AB Marl prairie, a diverse graminoid-dominated freshwater vegetation community in the Florida Everglades, provides a specialized niche for the federally endangered Cape Sable seaside sparrow (CSSS). This paper describes a regional habitat suitability modeling approach to evaluating how changes in management from Everglades restoration may affect the CSSS. The Cape Sable Seaside Sparrow Marl Prairie Indicator (CSSSMarlPrairie) is a spatially explicit model that integrates frequency (return periods) of target hydrologic conditions to simulate the anticipated response of marl prairie CSSS habitats to fluxing hydropatterns resulting from restoration projects, water management operations, and climatic change. The model integrates CSSS field survey data with the hydrologic targets at the resolution of the hydrologic simulation model (in this case, the Regional Simulation Model). The application of return periods for hydrologic events provides a novel approach for simulation of anticipated marl prairie responses in the southern Everglades and is readily applicable to evaluating targets-of modeled wetland restoration scenarios elsewhere. CSSSMarlPrairie is intended to be used for decision support, in association with a suite of ecological models for additional species of management concern, to facilitate planning of ecosystem restoration projects such as those in the Comprehensive Everglades Restoration Plan and recovery of the marl prairie habitats of the CSSS. A tentatively selected restoration plan for the central Everglades is projected to have mostly minor overall impacts to marl prairie CSSS habitats. Local substantial habitat shifts in and adjacent to designated habitat boundaries have been identified, however, that warrant management consideration. Published by Elsevier Ltd. C1 [Pearlstine, Leonard; Reynolds, Gregg; Parsons, Janice Holly; Dean, Tylan; Alvarado, Mario] Natl Pk Serv, South Florida Nat Resources Ctr, Homestead, FL 33030 USA. [Lo Galbo, Alicia] US Army Corps Engineers, Planning & Policy Branch, Div Water Resources, Norfolk, VA 23510 USA. [Suir, Kevin] US Geol Survey, Natl Wetlands Res Ctr, Lafayette, LA 70506 USA. RP Pearlstine, L (reprint author), Natl Pk Serv, South Florida Nat Resources Ctr, Everglades Natl Pk, Homestead, FL 33030 USA. EM Leonard_Pearlstine@nps.gov NR 28 TC 0 Z9 0 U1 1 U2 11 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1470-160X EI 1872-7034 J9 ECOL INDIC JI Ecol. Indic. PD JAN PY 2016 VL 60 BP 1252 EP 1262 DI 10.1016/j.ecolind.2015.09.018 PG 11 WC Biodiversity Conservation; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA CZ9GW UT WOS:000367407000124 ER PT J AU Skukalek, SL Winkler, AM Kang, J Dion, JE Cawley, CM Webb, A Dannenbaum, MJ Schuette, AJ Asbury, B Tong, FC AF Skukalek, Susana L. Winkler, Anne M. Kang, Jian Dion, Jacques E. Cawley, C. Michael Webb, Adam Dannenbaum, Mark J. Schuette, Albert J. Asbury, Bill Tong, Frank C. TI Effect of antiplatelet therapy and platelet function testing on hemorrhagic and thrombotic complications in patients with cerebral aneurysms treated with the pipeline embolization device: a review and meta-analysis SO JOURNAL OF NEUROINTERVENTIONAL SURGERY LA English DT Article DE Aneurysm; Complication; Flow Diverter ID SINGLE-CENTER EXPERIENCE; TERM-FOLLOW-UP; INTRACRANIAL ANEURYSMS; ENDOVASCULAR TREATMENT; RECONSTRUCTION; CLOPIDOGREL; TRIAL; STENT AB Purpose The pipeline embolization device (PED) necessitates dual antiplatelet therapy (APT) to decrease thrombotic complications while possibly increasing bleeding risks. The role of APT dose, duration, and response in patients with hemorrhagic and thromboembolic events warrants further analysis. Methods A PubMed and Google Scholar search from 2009 to 2014 was performed using the following search terms individually or in combination: pipeline embolization device, aneurysm(s), and flow diversion, excluding other flow diverters. Review of the bibliographies of the retrieved articles yielded 19 single and multicenter studies. A statistical meta-analysis between aspirin (ASA) dose (low dose 160mg, high dose 300mg), loading doses of APT agents, post-PED APT regimens, and platelet function testing (PFT) with hemorrhagic or thrombotic complications was performed. Results ASA therapy for 6months post-PED was associated with increased hemorrhagic events. High dose ASA 6months post-PED was associated with fewer thrombotic events compared with low dose ASA. Post-PED clopidogrel for 6months demonstrated an increased incidence of symptomatic thrombotic events. Loading doses of ASA plus clopidogrel demonstrated a decreased incidence of permanent symptomatic hemorrhagic events. PFT did not show a statistically significant relationship with symptomatic hemorrhagic or thrombotic complications. Conclusions High dose ASA >6months is associated with fewer permanent thrombotic and hemorrhagic events. Clopidogrel therapy 6months is associated with higher rates of thrombotic events. Loading doses of ASA and clopidogrel were associated with a decreased incidence of hemorrhagic events. PFT did not have any significant association with symptomatic events. C1 [Skukalek, Susana L.] Emory Clin, Dept Neurosurg, Atlanta, GA 30322 USA. [Skukalek, Susana L.] Emory Clin, Dept Radiol, Atlanta, GA 30322 USA. [Winkler, Anne M.] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA. [Kang, Jian] Emory Rollins Sch Publ Hlth, Dept Biostat & Bioinformat, Atlanta, GA USA. [Dion, Jacques E.; Cawley, C. Michael; Tong, Frank C.] Emory Univ, Sch Med, Dept Radiol, Atlanta, GA 30322 USA. [Dion, Jacques E.; Cawley, C. Michael; Webb, Adam; Tong, Frank C.] Emory Univ, Sch Med, Dept Neurosurg, Atlanta, GA USA. [Webb, Adam] Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA. [Dannenbaum, Mark J.] Univ Texas Houston, Dept Neurosurg, Houston, TX USA. [Schuette, Albert J.] Tripler Army Med Ctr, Dept Neurosurg, Honolulu, HI 96859 USA. [Asbury, Bill] Emory Univ Hosp, Atlanta, GA 30322 USA. RP Skukalek, SL (reprint author), Emory Clin, Dept Neurosurg, 1365B Clifton Rd,Suite 2200, Atlanta, GA 30322 USA. EM susana.skukalek@emoryhealthcare.org NR 24 TC 3 Z9 4 U1 0 U2 1 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1759-8478 EI 1759-8486 J9 J NEUROINTERV SURG JI J. NeuroInterventional Surg. PD JAN PY 2016 VL 8 IS 1 BP 58 EP 65 DI 10.1136/neurintsurg-2014-011145 PG 8 WC Neuroimaging; Surgery SC Neurosciences & Neurology; Surgery GA DA0IH UT WOS:000367480300016 PM 25385746 ER PT J AU Tandon, R Cucchiaro, J Phillips, D Hernandez, D Mao, YC Pikalov, A Loebel, A AF Tandon, Rajiv Cucchiaro, Josephine Phillips, Debra Hernandez, David Mao, Yongcai Pikalov, Andrei Loebel, Antony TI A double-blind, placebo-controlled, randomized withdrawal study of lurasidone for the maintenance of efficacy in patients with schizophrenia SO JOURNAL OF PSYCHOPHARMACOLOGY LA English DT Article DE Lurasidone; schizophrenia; relapse prevention; maintenance treatment; antipsychotic agents; drug therapy ID CONTROLLED TRIAL; RATING-SCALE; 160 MG/DAY; OPEN-LABEL; PREVENTION; RELAPSE; OLANZAPINE; TOLERABILITY; METAANALYSIS; EXTENSION AB Objective: To evaluate the effectiveness of lurasidone as maintenance treatment for schizophrenia. Method: Adults experiencing an acute exacerbation of schizophrenia initially received 12-24 weeks of open-label treatment with lurasidone (40-80 mg/d, flexibly dosed). Patients who maintained clinical stability for 12 weeks were randomized in double-blind fashion to placebo or lurasidone (40-80 mg/d, flexibly dosed) for an additional 28-week treatment period. The primary efficacy endpoint was time to relapse (based on Kaplan-Meier survival analysis). Results: A total of 676 patients enrolled in the open-label phase; 285 met protocol-specified stabilization criteria and were randomized to lurasidone (N=144) or placebo (N=141). During the open-label phase, mean Positive and Negative Syndrome Scale total score decreased from 90.1 to 54.4 in patients who met clinical stability criteria and were randomized. In the double-blind phase, lurasidone significantly delayed time to relapse compared with placebo (log-rank test, p=0.039), reflecting a 33.7% reduction in risk of relapse (Cox hazard ratio (95% confidence interval), 0.663 (0.447-0.983); p=0.041). Probability of relapse at the double-blind week 28 endpoint (based on Kaplan-Meier analysis) was 42.2% in the lurasidone group and 51.2% in the placebo group. Minimal changes in weight, lipid, glucose, and prolactin were observed throughout the study. Conclusions: This multicenter, placebo-controlled, randomized withdrawal study demonstrated the efficacy of lurasidone for the maintenance treatment of patients with schizophrenia. C1 [Tandon, Rajiv] Univ Florida, Coll Med, Gainesville, FL 32608 USA. [Cucchiaro, Josephine; Phillips, Debra; Hernandez, David; Mao, Yongcai; Pikalov, Andrei; Loebel, Antony] Sunov Pharmaceut Inc, Ft Lee, VA USA. [Cucchiaro, Josephine; Phillips, Debra; Hernandez, David; Mao, Yongcai; Pikalov, Andrei; Loebel, Antony] Sunov Pharmaceut Inc, Marlborough, NJ USA. RP Tandon, R (reprint author), Univ Florida, Coll Med, Psychiat, 1600 SW Archer Rd, Gainesville, FL 32608 USA. EM tandon@ufl.edu FU Sunovion Pharmaceuticals, Inc.; Takeda Pharmaceuticals International, Inc. FX The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Clinical research was sponsored by Sunovion Pharmaceuticals, Inc. and Takeda Pharmaceuticals International, Inc. The sponsors were involved in the study design, collection, and analysis of data. The interpretation of results and the decision to submit this manuscript for publication in the Journal of Psychopharmacology were made by the authors independently. NR 36 TC 2 Z9 2 U1 1 U2 4 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0269-8811 EI 1461-7285 J9 J PSYCHOPHARMACOL JI J. Psychopharmacol. PD JAN PY 2016 VL 30 IS 1 BP 69 EP 77 DI 10.1177/0269881115620460 PG 9 WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA CZ8XL UT WOS:000367382300009 PM 26645209 ER PT J AU Henry, TC Bakis, CE Riddick, JC AF Henry, Todd C. Bakis, Charles E. Riddick, Jaret C. TI Three-dimensional elastic behavior of undulating laminas in fiber composites SO JOURNAL OF REINFORCED PLASTICS AND COMPOSITES LA English DT Article DE Homogenization; composites; undulation; anisotropy ID WOVEN FABRIC COMPOSITES; TEXTILE STRUCTURAL COMPOSITES; PREDICTION; STIFFNESS; CONSTANTS; MODELS; MODULI AB Analytical models have been developed in recent years for predicting the elastic properties of fiber reinforced composite laminates with undulated laminas, such as woven and filament wound composites. In these models, a representative volume element (RVE) is defined, assumptions about how strains or stresses vary throughout the RVE are made, and then the homogenized constitutive behavior of the RVE is calculated. The constitutive behavior has been modeled in the context of either two-dimensional plate behavior or three-dimensional continuum behavior. Of the latter genre, the few existing models capable of handling undulated laminas have not captured the full three-dimensional constitutive behavior, including all the out-of-plane couplings arising from the most general undulation configurations. Building on the existing models, the current investigation utilizes micromechanics to determine the three-dimensional stiffness at discrete stations along the length of an RVE containing an undulated lamina, and determines the overall RVE constitutive behavior by averaging either the stiffness or compliance along the length of the RVE, thus providing bounds on the material behavior. The new model is evaluated by comparison with existing models as well as experiments for laminates with and without undulations. Similarities and differences with previous models are discussed. C1 [Henry, Todd C.; Riddick, Jaret C.] US Army, Res Lab, Vehicle Technol Directorate, Adelphi, MD USA. [Bakis, Charles E.] Penn State Univ, Dept Engn Sci & Mech, University Pk, PA 16802 USA. RP Henry, TC (reprint author), Army Res Lab, 4603 Flare Loop, Aberdeen, MD 21005 USA. EM todd.c.henry2.civ@mail.mil NR 28 TC 1 Z9 1 U1 2 U2 7 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0731-6844 EI 1530-7964 J9 J REINF PLAST COMP JI J. Reinf. Plast. Compos. PD JAN PY 2016 VL 35 IS 2 BP 151 EP 164 DI 10.1177/0731684415609429 PG 14 WC Materials Science, Composites; Polymer Science SC Materials Science; Polymer Science GA CZ9XW UT WOS:000367452200005 ER PT J AU Slaughter, AJ Koehly, LM AF Slaughter, Andrew J. Koehly, Laura M. TI Multilevel models for social networks: Hierarchical Bayesian approaches to exponential random graph modeling SO SOCIAL NETWORKS LA English DT Article DE Multilevel networks; Hierarchical models; Exponential random graph models; Autoregressive models ID LOGISTIC-REGRESSION; UNCERTAINTY; SAMPLER AB In many applications, researchers may be interested in studying patterns of dyadic relationships that involve multiple groups, with a focus on modeling the systematic patterns within groups and how these structural patterns differ across groups. A number of different models - many of them potentially quite powerful - have been developed that allow for researchers to study these differences. However, as with any set of models, these are limited in ways that constrain the types of questions researchers may ask, such as those involving the variance in group-wise structural features. In this paper, we demonstrate some of the ways in which multilevel models based on a hierarchical Bayesian approach might be used to further develop and extend existing exponential random graph models to address such constraints. These include random coefficient extensions to the standard ERGM for sets of multiple unconnected or connected networks and examples of multilevel models that allow for the estimation of structural entrainment among connected groups. We demonstrate the application of these models to real-world and simulated data sets. Published by Elsevier B.V. C1 [Slaughter, Andrew J.] US Army Res Inst Behav & Social Sci, Arlington, VA 22202 USA. [Koehly, Laura M.] NHGRI, Bethesda, MD USA. RP Slaughter, AJ (reprint author), US Army Res Inst Behav & Social Sci, Arlington, VA 22202 USA. EM andrew.j.slaughter.civ@mail.mil; koehlyl@mail.nih.gov FU Breast Cancer Research Program, The University of Texas M.D. Anderson Cancer Center; Intramural Research Program of the National Human Genome Research Institute at the National Institutes of Health [ZIA HG200335]; US Army Research Institute for the Behavioral and Social Sciences FX The Circle of Friends study, which provided exemplar data, was supported by the Breast Cancer Research Program, The University of Texas M.D. Anderson Cancer Center. We would like to thank Karen Basen-Engquist for her assistance in obtaining the Circle of Friends data. The completion of this manuscript was supported by the Intramural Research Program of the National Human Genome Research Institute at the National Institutes of Health (ZIA HG200335 to Laura M. Koehly) and the US Army Research Institute for the Behavioral and Social Sciences. The views, opinions, and/or findings contained in this article are solely those of the authors and should not be construed as an official Department of the Army or DOD position, policy, or decision, unless so designated by other documentation. NR 42 TC 0 Z9 1 U1 2 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-8733 EI 1879-2111 J9 SOC NETWORKS JI Soc. Networks PD JAN PY 2016 VL 44 BP 334 EP 345 DI 10.1016/j.socnet.2015.11.002 PG 12 WC Anthropology; Sociology SC Anthropology; Sociology GA CZ9NI UT WOS:000367423900030 ER PT J AU Hourigan, LA Omaye, ST Keen, CL Jones, JA Dubick, MA AF Hourigan, Leslie A. Omaye, Stanley T. Keen, Carl L. Jones, John A. Dubick, Michael A. TI Vitamin and Trace Element Loss from Negative-Pressure Wound Therapy SO ADVANCES IN SKIN & WOUND CARE LA English DT Article DE wound exudate; micronutrients; vitamins; minerals; negative pressure wound therapy ID RETINOL-BINDING-PROTEIN; CRITICALLY-ILL; SURROGATE MEASURE; SUPPLEMENTATION; NUTRITION; TRAUMA; COPPER AB OBJECTIVE: This study investigated select vitamin and trace element loss from wound exudates in burn and trauma patients treated with negative-pressure wound therapy (NPWT). DESIGN: A prospective observational study was performed using wound exudate samples. SETTING: A level I trauma center acute care hospital. PARTICIPANTS: The study was composed of 8 patients with open abdomens and 9 patients with 12 soft-tissue wounds. MAIN OUTCOME MEASURES: The goal was to collect wound exudate samples daily for 3 days, then every other day to day 9 or until NPWT was discontinued, and to analyze for vitamins A (retinol), C, and E and zinc (Zn), iron (Fe), and copper (Cu). Daily loss of each micronutrient was calculated from their concentration and 24-hour volumes of the exudates. MAIN RESULTS: Exudate loss in the open-abdomen group was significantly higher than in the patients with soft-tissue wounds (900 547 vs 359 +/- 246 mL/d). The mean 24-hour loss of vitamins A, C, and E were 0.3, 2.8, and 11 mg, respectively, in the open-abdomen group. Over the same period, the losses of Zn, Fe, and Cu were 0.5, 0.4, and 0.25 mg, respectively, in these patients. Micronutrient 24-hour loss was significantly lower in the soft-tissue wound patients than in the open-abdomen group. CONCLUSIONS: The data support the concept that significant amounts of micronutrients can be lost from NPWT wound exudates, particularly in open abdomens. These losses should be considered in the nutritional support of these patients who typically are in a hypermetabolic and catabolic state. C1 [Hourigan, Leslie A.] Brooke Army Med Ctr, San Antonio, TX 78234 USA. [Omaye, Stanley T.] Univ Nevada, Dept Agr Nutr & Vet Sci, Reno, NV 89557 USA. [Keen, Carl L.] Univ Calif Davis, Nutr & Internal Med, Davis, CA 95616 USA. [Jones, John A.] US Army Inst Surg Res, San Antonio, TX USA. [Dubick, Michael A.] US Army Inst Surg Res, DCR Res Program, San Antonio, TX USA. RP Hourigan, LA (reprint author), Brooke Army Med Ctr, San Antonio, TX 78234 USA. NR 32 TC 1 Z9 1 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1527-7941 EI 1538-8654 J9 ADV SKIN WOUND CARE JI Adv. Skin Wound Care PD JAN PY 2016 VL 29 IS 1 BP 20 EP 25 DI 10.1097/01.ASW.0000473680.06666.6a PG 6 WC Dermatology; Nursing; Surgery SC Dermatology; Nursing; Surgery GA CZ2LP UT WOS:000366937000004 ER PT J AU Lloyd, JR Jayasekara, PS Jacobson, KA AF Lloyd, John R. Jayasekara, P. Suresh Jacobson, Kenneth A. TI Characterization of polyamidoamino (PAMAM) dendrimers using in-line reversed phase LC electrospray ionization mass spectrometry SO ANALYTICAL METHODS LA English DT Article ID POLY(AMIDOAMINE) DENDRIMERS; COMPLEXES; SILICA AB Generation 3 (G3) PAMAM dendrimers are symmetrical, highly branched polymers widely reported in the scientific literature as therapeutic agents themselves or as carrier scaffolds for various therapeutic agents. A large number of analytical techniques have been applied to study PAMAM dendrimers, but one that has been missing is in-line reversed phase LC electrospray ionization mass spectrometry (RP/LC/ESI/MS). To translate PAMAM dendrimers into therapeutic agents, a better understanding of their purity, stability and structure is required, and in-line RP/LC/ESI/MS is widely applied to all three of these analytical questions. In this study, we developed a robust in-line RP/LC/ESI/MS method for assessing stability, purity and structure of the G3 PAMAM dendrimers, and we also examined the reasons why previous attempts at method development failed. Using the RP/LC/ESI/MS method we uncovered several unique aspects of the chemistry of G3 PAMAM dendrimers. They are interconverted between two isomeric forms by dialysis, and under higher concentration levels there is an inter-molecular displacement reaction resulting, which degrades PAMAM dendrimers. Purification of G3 dendrimers by RP/LC was also previously unreported; so we slightly modified the LC/MS method for isolating individual components from a complex dendrimer mixture. Thus, we have developed a robust, comprehensive method for characterizing PAMAM dendrimers and their degradation. C1 [Lloyd, John R.; Jayasekara, P. Suresh; Jacobson, Kenneth A.] NIDDK, Bioorgan Chem Lab, NIH, Bethesda, MD 20892 USA. [Jayasekara, P. Suresh] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Jacobson, KA (reprint author), NIDDK, Bioorgan Chem Lab, NIH, Bethesda, MD 20892 USA. EM kajacobs@helix.nih.gov RI Jacobson, Kenneth/A-1530-2009 OI Jacobson, Kenneth/0000-0001-8104-1493 FU Intramural Research Program of the NIH, NIDDK FX We thank the Intramural Research Program of the NIH, NIDDK for support. NR 32 TC 1 Z9 1 U1 1 U2 15 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1759-9660 EI 1759-9679 J9 ANAL METHODS-UK JI Anal. Methods PY 2016 VL 8 IS 2 BP 263 EP 269 DI 10.1039/c5ay01995h PG 7 WC Chemistry, Analytical; Food Science & Technology; Spectroscopy SC Chemistry; Food Science & Technology; Spectroscopy GA CZ6XF UT WOS:000367243600005 PM 26997980 ER PT J AU George, J AF George, Jemin TI A robust estimator for stochastic systems under unknown persistent excitation SO AUTOMATICA LA English DT Article DE Robust estimator; Unknown input observer; Kalman filter; Unbiased minimum-variance filter; Stochastic systems ID RECURSIVE STATE ESTIMATION; LINEAR-SYSTEMS; UNCERTAIN SYSTEMS; INPUTS; OBSERVERS; CONSTRAINT; DESIGN; FILTER AB A robust estimator for uncertain stochastic systems under unknown persistent disturbance is presented. The given discrete-time stochastic formulation neither requires a known bound on the magnitude of the unknown excitation nor assumes stability of the system. However, the proposed estimator assumes certain structural conditions on system uncertainties. Though the proposed estimator is developed based on stochastic Lyapunov analysis, its structure and performance are comparable to that of unbiased minimum-variance filters based on the disturbance decoupling technique. Unlike unbiased minimum-variance filters, implementation of the developed estimator only requires adding an auxiliary term to the nominal steady-state Kalman filter, and it does not involve any similarity transformation or propagation of matrix difference equations. Published by Elsevier Ltd. C1 [George, Jemin] US Army Res Lab, Adelphi, MD 20783 USA. RP George, J (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM jemin.george.civ@mail.mil NR 24 TC 2 Z9 2 U1 2 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0005-1098 EI 1873-2836 J9 AUTOMATICA JI Automatica PD JAN PY 2016 VL 63 BP 156 EP 161 DI 10.1016/j.automatica.2015.10.006 PG 6 WC Automation & Control Systems; Engineering, Electrical & Electronic SC Automation & Control Systems; Engineering GA CZ5CF UT WOS:000367119300019 ER PT J AU Minnicino, MA Santare, MH AF Minnicino, Michael A. Santare, Michael H. TI Predicting microdroplet force response using a multiscale modeling approach SO COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING LA English DT Article DE Finite element analysis (FEA); Damage mechanics; Interface/interphase; Micro-mechanics ID FIBER-MATRIX INTERPHASE; MICROBOND TEST; FIBER/MATRIX INTERFACE; POLYMER COMPOSITES; COLLOIDAL SILICA; SHEAR-STRENGTH; BOND STRENGTH; GLASS-FIBERS; PULL-OUT; TESTS AB An axisymmetric microscale finite element model of a microdroplet test specimen is developed where the structural response of the fiber-droplet interface is accounted for by surface-based cohesive behavior. In this study, the interface cohesive response is estimated using a nanoscale interface finite element model that explicitly includes the effects of fiber surface topography and the interphase region. The interphase behavior in the nanoscale interface model is calibrated using indirect experimental data. Once calibrated, the fiber surface topography in the nanoscale interface model is modified in order to estimate the parameters defining the surface-based cohesive behavior of similar fiber-matrix systems with different fiber topography. The effect of altering the fiber topography on the force response of the microdroplet test can then be predicted by the microdroplet FE model. Comparing the simulation results with experimental data from the literature shows that this multiscale modeling approach gives accurate predictions for the interfacial shear stress. Published by Elsevier Ltd. C1 [Minnicino, Michael A.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Minnicino, Michael A.; Santare, Michael H.] Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. [Minnicino, Michael A.; Santare, Michael H.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. RP Minnicino, MA (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM michael.a.minnicino.civ@mail.mil NR 39 TC 0 Z9 0 U1 7 U2 16 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-835X EI 1878-5840 J9 COMPOS PART A-APPL S JI Compos. Pt. A-Appl. Sci. Manuf. PD JAN PY 2016 VL 80 BP 39 EP 52 DI 10.1016/j.compositesa.2015.10.005 PG 14 WC Engineering, Manufacturing; Materials Science, Composites SC Engineering; Materials Science GA CZ5FB UT WOS:000367126800005 ER PT J AU Zizzi, S Kadushin, P Michel, J Abildso, C AF Zizzi, Sam Kadushin, Peter Michel, Jesse Abildso, Christiaan TI Client Experiences With Dietary, Exercise, and Behavioral Services in a Community-Based Weight Management Program SO HEALTH PROMOTION PRACTICE LA English DT Article DE weight loss; weight management; nutrition; physical activity; behavioral therapy ID PHYSICAL-ACTIVITY; RANDOMIZED-TRIAL; OBESITY; INTERVENTIONS; MAINTENANCE; PREVENTION; SETTINGS; SCIENCE AB Compared with randomized trials, community-based interventions are delivered by a wider variety of professionals with varied training backgrounds. When evidence-based programs are scaled into larger formats and disseminated to a wider audience, little is understood about how clients experience these interventions. To understand the experience of clients after meetings with nutrition, exercise, and health behavior professionals, researchers surveyed participants after 6 months in a weight management program. A total of 958 participants were recruited in monthly cohorts beginning September 2011 to complete a program evaluation survey. Qualitative inductive analysis was completed on several open-text items querying respondents as to what they found helpful from meetings with a registered dietitian, personal trainer, and health behavior counselor. Results indicate participants benefitted from gaining knowledge, learning new behavioral skills, or from interpersonal interactions. Findings suggest that the various professional services are valued by clients and that professionals appear to stay within their scope of practice. Implications for those working in weight management are discussed. C1 [Zizzi, Sam] W Virginia Univ, Coll Phys Act & Sport Sci, Morgantown, WV 26506 USA. [Kadushin, Peter] Western State Colorado Univ, Gunnison, CO USA. [Michel, Jesse] US Army, Comprehens Soldier & Family Fitness Program, Honolulu, HI USA. [Abildso, Christiaan] W Virginia Univ, Sch Publ Hlth, Morgantown, WV 26506 USA. RP Zizzi, S (reprint author), W Virginia Univ, Dept Sport Sci, Morgantown, WV 26506 USA. EM szizzi@mail.wvu.edu NR 29 TC 0 Z9 0 U1 1 U2 6 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1524-8399 EI 1552-6372 J9 HEALTH PROMOT PRACT JI Health Promot. Pract. PD JAN PY 2016 VL 17 IS 1 BP 98 EP 106 DI 10.1177/1524839915610316 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CZ7WG UT WOS:000367310500012 PM 26482344 ER PT J AU Baron, A Lindsey, K Sidow, SJ Dickinson, D Chuang, A McPherson, JC AF Baron, Aleksandr Lindsey, Kimberly Sidow, Stephanie J. Dickinson, Douglas Chuang, Augustine McPherson, James C. TI Effect of a Benzalkonium Chloride Surfactant-Sodium Hypochlorite Combination on Elimination of Enterococcus faecalis SO JOURNAL OF ENDODONTICS LA English DT Article DE Benzalkonium chloride; biofilm; dentin tubules; Enterococcus faecalis ID ROOT CANALS; DISINFECTING SOLUTIONS; APICAL PERIODONTITIS; ENDODONTIC TREATMENT; IN-VITRO; BIOFILM; DENTIN; PENETRATION; DISSOLUTION; IRRIGANTS AB Introduction: The purpose of this investigation was to determine the effect of a sodium hypochlorite surfactant combination on the removal of Enterococcus faecalis from infected teeth. Methods: Sixty-four extracted human single canal anterior teeth were prepared with rotary instrumentation and sterilized. Teeth were divided into 4 groups, N = 16. Three experimental groups were inoculated with E. faecalis and cultured for 21 days before use: positive control group, no irrigation; NaOCl group, irrigated with 5 mL 6% NaOCl; and NaOCl/BAK group, irrigated with 5 mL 6% NaOCl/0.008% benzalkonium chloride (BAK). The negative control group received medium only and no inoculate. Paper point sampling of the canals was obtained before irrigation (Si) for all 4 groups and for 2 groups after irrigation (52) to determine remaining colony-forming units. After sampling, all teeth were split in half and evaluated for bacterial viability colony-forming units and penetration of dentinal tubules by using fluorescent vital dye staining and confocal laser scanning microscopy. Results: Comparison of pre-irrigation and post-irrigation paper point samples from the 2 irrigated groups showed a significant reduction in bacterial canal load (P < .001, Kruskal-Wallis), with a significantly lower load in the NaOCl/BAK group than in the NaOCl group (P = .001, Mann-Whitney U test); 68.8% of the NaOCl/BAK samples gave no recoverable counts. In contrast, no significant difference between these groups was found for counts recovered from dentin. Confocal laser scanning microscopy showed no differences in tubule penetration. Conclusions: The addition of BAK to NaOCl significantly reduced the number of remaining bacteria within the canal after irrigation compared with NaOCl alone. C1 [Baron, Aleksandr; Lindsey, Kimberly; Sidow, Stephanie J.; Dickinson, Douglas] US Army, Dent Activ, Ft Gordon, GA 30905 USA. [Chuang, Augustine; McPherson, James C.] Dwight D Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA USA. RP Lindsey, K (reprint author), US Army, Dent Activ, Dept Endodont, Ft Gordon, GA 30905 USA. EM kimberly.w.lindsey.mil@mail.mil NR 36 TC 0 Z9 0 U1 1 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0099-2399 EI 1878-3554 J9 J ENDODONT JI J. Endod. PD JAN PY 2016 VL 42 IS 1 BP 145 EP 149 DI 10.1016/j.joen.2015.08.035 PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA CZ5BM UT WOS:000367117100025 PM 26577873 ER PT J AU Cuddy, MF Poda, AR Moser, RD Weiss, CA Cairns, C Steevens, JA AF Cuddy, Michael F. Poda, Aimee R. Moser, Robert D. Weiss, Charles A. Cairns, Carolyn Steevens, Jeffery A. TI A weight-of-evidence approach to identify nanomaterials in consumer products: a case study of nanoparticles in commercial sunscreens SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY LA English DT Article DE FFF; nanoparticles; sunscreen; TiO2; Weight-of-evidence; ZnO ID SILVER NANOPARTICLES; TIO2; FOOD; TOXICITY AB Nanoscale ingredients in commercial products represent a point of emerging environmental concern due to recent findings that correlate toxicity with small particle size. A weight-of-evidence (WOE) approach based upon multiple lines of evidence (LOE) is developed here to assess nanomaterials as they exist in consumer product formulations, providing a qualitative assessment regarding the presence of nanomaterials, along with a baseline estimate of nanoparticle concentration if nanomaterials do exist. Electron microscopy, analytical separations, and X-ray detection methods were used to identify and characterize nanomaterials in sunscreen formulations. The WOE/LOE approach as applied to four commercial sunscreen products indicated that all four contained at least 10% dispersed primary particles having at least one dimension < 100 nm in size. Analytical analyses confirmed that these constituents were comprised of zinc oxide (ZnO) or titanium dioxide (TiO2). The screening approaches developed herein offer a streamlined, facile means to identify potentially hazardous nanomaterial constituents with minimal abrasive processing of the raw material. C1 [Cuddy, Michael F.; Poda, Aimee R.; Steevens, Jeffery A.] US Army, Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Moser, Robert D.; Weiss, Charles A.] US Army, Corps Engineers, Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. RP Cuddy, MF (reprint author), Northwest Coll, Dept Chem, 231 W 6th St Powell, Powell, WY 82435 USA. EM michael.cuddy@nwc.edu RI Poda, Aimee/K-1905-2012 NR 18 TC 1 Z9 1 U1 6 U2 27 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1559-0631 EI 1559-064X J9 J EXPO SCI ENV EPID JI J. Expo. Sci. Environ. Epidemiol. PD JAN-FEB PY 2016 VL 26 IS 1 BP 26 EP 34 DI 10.1038/jes.2015.51 PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA CZ5PY UT WOS:000367155700004 PM 26374657 ER PT J AU Mizukami, N Clark, MP Gutmann, ED Mendoza, PA Newman, AJ Nijssen, B Ben Livneh, Hay, LE Arnold, JR Brekke, LD AF Mizukami, Naoki Clark, Martyn P. Gutmann, Ethan D. Mendoza, Pablo A. Newman, Andrew J. Nijssen, Bart Ben Livneh Hay, Lauren E. Arnold, Jeffrey R. Brekke, Levi D. TI Implications of the Methodological Choices for Hydrologic Portrayals of Climate Change over the Contiguous United States: Statistically Downscaled Forcing Data and Hydrologic Models SO JOURNAL OF HYDROMETEOROLOGY LA English DT Article ID DAILY SOLAR-RADIATION; COLORADO RIVER-BASIN; SIERRA-NEVADA; LAND-SURFACE; WATER-RESOURCES; CHANGE IMPACTS; TEMPERATURE; CALIFORNIA; SCALE; PRECIPITATION AB Continental-domain assessments of climate change impacts on water resources typically rely on statistically downscaled climate model outputs to force hydrologic models at a finer spatial resolution. This study examines the effects of four statistical downscaling methods [bias-corrected constructed analog (BCCA), bias-corrected spatial disaggregation applied at daily (BCSDd) and monthly scales (BCSDm), and asynchronous regression (AR)] on retrospective hydrologic simulations using three hydrologic models with their default parameters (the Community Land Model, version 4.0; the Variable Infiltration Capacity model, version 4.1.2; and the Precipitation-Runoff Modeling System, version 3.0.4) over the contiguous United States (CONUS). Biases of hydrologic simulations forced by statistically downscaled climate data relative to the simulation with observation-based gridded data are presented. Each statistical downscaling method produces different meteorological portrayals including precipitation amount, wet-day frequency, and the energy input (i.e., shortwave radiation), and their interplay affects estimations of precipitation partitioning between evapotranspiration and runoff, extreme runoff, and hydrologic states (i.e., snow and soil moisture). The analyses show that BCCA underestimates annual precipitation by as much as -250 mm, leading to unreasonable hydrologic portrayals over the CONUS for all models. Although the other three statistical downscaling methods produce a comparable precipitation bias ranging from -10 to 8 mm across the CONUS, BCSDd severely overestimates the wet-day fraction by up to 0.25, leading to different precipitation partitioning compared to the simulations with other downscaled data. Overall, the choice of downscaling method contributes to less spread in runoff estimates (by a factor of 1.5-3) than the choice of hydrologic model with use of the default parameters if BCCA is excluded. C1 [Mizukami, Naoki; Clark, Martyn P.; Gutmann, Ethan D.; Mendoza, Pablo A.; Newman, Andrew J.] Natl Ctr Atmospher Res, Boulder, CO 80307 USA. [Nijssen, Bart] Univ Washington, Seattle, WA 98195 USA. [Ben Livneh] Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA. [Hay, Lauren E.] US Geol Survey, Denver, CO 80225 USA. [Arnold, Jeffrey R.] US Army Corps Engineers, Seattle, WA USA. [Brekke, Levi D.] US Bur Reclamat, Denver, CO 80225 USA. [Ben Livneh] Univ Colorado, Dept Civil Environm & Architectural Engn, Boulder, CO 80309 USA. RP Mizukami, N (reprint author), NCAR, POB 3000, Boulder, CO 80307 USA. EM mizukami@ucar.edu RI Mizukami, Naoki/J-7027-2015; Gutmann, Ethan/I-5728-2012; Nijssen, Bart/B-1013-2012; OI Gutmann, Ethan/0000-0003-4077-3430; Nijssen, Bart/0000-0002-4062-0322; LIVNEH, BEN/0000-0001-5445-2473 FU U.S Bureau of Reclamation; U.S Army Corps of Engineers FX This work was financially supported by the U.S Bureau of Reclamation and the U.S Army Corps of Engineers. The authors thank Steven Markstrom, Steve Regan, and Roland Viger of the USGS for providing PRMS parameters and Youlong Xia and Justin Sheffield for providing VIC parameters. Finally, the authors are grateful to Stacey Archfield and three anonymous reviewers for their constructive comments. NR 99 TC 8 Z9 8 U1 7 U2 12 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1525-755X EI 1525-7541 J9 J HYDROMETEOROL JI J. Hydrometeorol. PD JAN PY 2016 VL 17 IS 1 BP 73 EP 98 DI 10.1175/JHM-D-14-0187.1 PG 26 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA CZ9FH UT WOS:000367402700003 ER PT J AU Park, AM Wycisk, RJ Ren, XM Turley, FE Pintauro, PN AF Park, Andrew M. Wycisk, Ryszard J. Ren, Xiaoming Turley, Forbes E. Pintauro, Peter N. TI Crosslinked poly(phenylene oxide)-based nanofiber composite membranes for alkaline fuel cells SO JOURNAL OF MATERIALS CHEMISTRY A LA English DT Article ID ANION-EXCHANGE MEMBRANES; CONDUCTING MEMBRANES; NMR-SPECTROSCOPY; STABILITY; DEGRADATION; PERFORMANCE; HYDROXIDE; TRANSPORT; POLYMER; COPOLYMER AB Anion exchange membranes were fabricated from diamine-crosslinked poly(phenylene oxide) polyelectrolyte nanofibers that were functionalized with either benzyl trimethylammonium or 1,2-dimethylimidazolium groups and embedded in a reinforcing matrix of polyphenylsulfone (PPSU). Nanofibers of the polyelectrolyte precursor, brominated poly(phenylene oxide) with 0.95 CH2Br groups per mer, and PPSU were simultaneously electrospun onto a common collector and the resulting dual fiber mat was converted into a dense and defect-free anion exchange membrane by sequential soaking in a diamine crosslinker solution, exposure to chloroform vapor, and immersion in a solution of either trimethylamine or 1,2-dimethylimidazole. The degree of crosslinking and the ratio of uncharged PPSU to functionalized poly(phenylene oxide) polyelectrolyte were varied to yield composite membranes with an effective ion exchange capacity (IEC) ranging from 1.2-2.8 mmol g(-1). A membrane with benzyl trimethylammonium-functionalized polyelectrolyte fibers (4.0 mmol g(-1) IEC) with 15% crosslinks and 50 wt% uncharged PPSU exhibited a high hydroxide ion conductivity in water at 23 degrees C (66 mS cm(-1)), reasonable water swelling (96%), robust mechanical properties (15 MPa stress-at-break in the hydrated state), and good chemical stability in 1.0 M KOH at 60 degrees C. Initial hydrogen/oxygen fuel cell tests with this membrane (40 mm thick) were promising, with a peak power density of 320 mW cm(-2). C1 [Park, Andrew M.; Wycisk, Ryszard J.; Turley, Forbes E.; Pintauro, Peter N.] Vanderbilt Univ, Dept Chem & Biomol Engn, Nashville, TN 37235 USA. [Ren, Xiaoming] US Army, Res Lab, RDRL SED C, Adelphi, MD 20783 USA. RP Pintauro, PN (reprint author), Vanderbilt Univ, Dept Chem & Biomol Engn, 221 Kirkland Hall, Nashville, TN 37235 USA. EM peter.pintauro@vanderbilt.edu FU Army Research Office [W911NF-11-1-0454]; National Science Foundation [CBET-1032948] FX The authors thank the Army Research Office, (Contract No. W911NF-11-1-0454) and the National Science Foundation (Grant CBET-1032948) for their financial support of this research. NR 41 TC 6 Z9 6 U1 9 U2 52 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2050-7488 EI 2050-7496 J9 J MATER CHEM A JI J. Mater. Chem. A PY 2016 VL 4 IS 1 BP 132 EP 141 DI 10.1039/c5ta06209h PG 10 WC Chemistry, Physical; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Energy & Fuels; Materials Science GA CZ0VX UT WOS:000366825300012 ER PT J AU Loers, G Saini, V Mishra, B Gul, S Chaudhury, S Wallqvist, A Kaur, G Schachner, M AF Loers, Gabriele Saini, Vedangana Mishra, Bibhudatta Gul, Sheraz Chaudhury, Sidhartha Wallqvist, Anders Kaur, Gurcharan Schachner, Melitta TI Vinorelbine and epirubicin share common features with polysialic acid and modulate neuronal and glial functions SO JOURNAL OF NEUROCHEMISTRY LA English DT Article DE epirubicin; migration; neural cell adhesion molecule; neurite outgrowth; polysialic acid; vinorelbine ID CELL-ADHESION MOLECULE; PSYCHIATRIC-DISORDER PATIENTS; TEMPORAL-LOBE EPILEPSY; SPINAL-CORD-INJURY; PSA-NCAM; NERVOUS-SYSTEM; SCHWANN-CELLS; NEURITE OUTGROWTH; SYNAPTIC PROTEINS; EXPRESSION AB Polysialic acid (PSA), a large, linear glycan composed of 8 to over 100 2,8-linked sialic acid residues, modulates development of the nervous system by enhancing cell migration, axon pathfinding, and synaptic targeting and by regulating differentiation of progenitor cells. PSA also functions in developing and adult immune systems and is a signature of many cancers. In this study we identified vinorelbine, a semi-synthetic third generation vinca alkaloid, and epirubicin, an anthracycline and 4-epimer of doxorubicin, as PSA mimetics. Similar to PSA, vinorelbine and epirubicin bind to the PSA-specific monoclonal antibody 735 and compete with the bacterial analog of PSA, colominic acid in binding to monoclonal antibody 735. Vinorelbine and epirubicin stimulate neurite outgrowth of cerebellar neurons via the neural cell adhesion molecule, via myristoylated alanine-rich C kinase substrate, and via fibroblast growth factor receptor, signaling through Erk pathways. Furthermore, the two compounds enhance process formation of Schwann cells and migration of cerebellar neurons in culture, and reduce migration of astrocytes after injury. These novel results show that the structure and function of PSA can be mimicked by the small organic compounds vinorelbine and epirubicin, thus raising the possibility to re-target drugs used in treatment of cancers to nervous system repair. C1 [Loers, Gabriele; Mishra, Bibhudatta; Schachner, Melitta] Univ Klinikum Hamburg Eppendorf, Zentrum Mol Neurobiol Hamburg, Hamburg, Germany. [Saini, Vedangana; Kaur, Gurcharan] Guru Nanak Dev Univ, Dept Biotechnol, Amritsar, Punjab, India. [Gul, Sheraz] Fraunhofer Inst Mol Biol & Appl Ecol Screening Po, Hamburg, Germany. [Chaudhury, Sidhartha; Wallqvist, Anders] US Army, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, DoD Biotechnol High Performance Comp Software App, Ft Detrick, MD USA. [Schachner, Melitta] Rutgers State Univ, Keck Ctr Collaborat Neurosci, Piscataway, NJ USA. [Schachner, Melitta] Rutgers State Univ, Dept Cell Biol & Neurosci, Piscataway, NJ USA. [Schachner, Melitta] Shantou Univ, Coll Med, Ctr Neurosci, Shantou, Guangdong, Peoples R China. RP Schachner, M (reprint author), Univ Klinikum Hamburg Eppendorf, Zentrum Mol Neurobiol Hamburg, Inst Biosynth Neuraler Strukt, Hamburg, Germany. EM kgurcharan.neuro@yahoo.com; melitta.schachner@zmnh.uni-hamburg.de OI wallqvist, anders/0000-0002-9775-7469; Saini, Vedangana/0000-0002-9944-0262 FU Council of Scientific and Industrial Research (CSIR) India; DAAD, Germany; NIH [RO1 NS078385-01A1]; Bundesministerium fur Bildung und Forschung (BMBF); Indian Council of Medical Research (ICMR) (Indo-German Research Project) [10/050]; U.S. Army Medical Research and Materiel Command Clinical and Rehabilitative Medicine Research Program FX The authors are grateful to Dr Rita Gerardy-Schahn for donation of the antibody 735 and EndoN, Markus Wolf and Ute Bork for excellent technical assistance, Eva Kronberg for excellent animal care, and Philip Gribbon for help with the screening setup. Vedangana Saini thanks the Council of Scientific and Industrial Research (CSIR) India for a Senior Research Fellowship and the DAAD for a 6-month research scholarship in Germany. Infrastructure provided by University Grants Commission (UGC), India, under the UPE and CPEPA schemes and Department of Biotechnology (DBT), India, under the DISC facility is highly acknowledged. Melitta Schachner thanks the NIH for support. This work was supported by the Bundesministerium fur Bildung und Forschung (BMBF) and Indian Council of Medical Research (ICMR) (Indo-German Research Project 10/050 to Melitta Schachner and Gurcharan Kaur), the U.S. Army Medical Research and Materiel Command Clinical and Rehabilitative Medicine Research Program (to Anders Wallqvist and Sidhartha Chaudhury), and the NIH grant RO1 NS078385-01A1 (to Melitta Schachner). The authors declare that no competing interests exist. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or the U.S. Department of Defense. This paper has been approved for public release with unlimited distribution. NR 74 TC 1 Z9 1 U1 1 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-3042 EI 1471-4159 J9 J NEUROCHEM JI J. Neurochem. PD JAN PY 2016 VL 136 IS 1 BP 48 EP 62 DI 10.1111/jnc.13383 PG 15 WC Biochemistry & Molecular Biology; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA CZ6DZ UT WOS:000367192700005 PM 26443186 ER PT J AU Littlefield, PD Pinto, RL Burrows, HL Brungart, DS AF Littlefield, Philip D. Pinto, Robin L. Burrows, Holly L. Brungart, Douglas S. TI The Vestibular Effects of Repeated Low-Level Blasts SO JOURNAL OF NEUROTRAUMA LA English DT Article DE military injury; peripheral nerve injury; traumatic brain injury ID TRAUMATIC BRAIN-INJURY; POSITION UPBEAT NYSTAGMUS; NORMATIVE DATA; EXPOSURE; ENCEPHALOPATHY; PREGABALIN; VERTIGO; IRAQ AB The objective of this study was to use a prospective cohort of United States Marine Corps (USMC) instructors to identify any acute or long-term vestibular dysfunction following repeated blast exposures during explosive breaching training. They were assessed in clinic and on location during training at the USMC Methods of Entry School, Quantico, VA. Subjects received comprehensive baseline vestibular assessments and these were repeated in order to identify longitudinal changes. They also received shorter assessments immediately following blast exposure in order to identify acute findings. The main outcome measures were the Neurobehavioral Symptom Inventory, vestibular Visual Analog Scale (VAS) of subjective vestibular function, videonystagmography (VNG), vestibular evoked myogenic potentials (VEMP), rotary chair (including the unilateral centrifugation test), computerized dynamic posturography, and computerized dynamic visual acuity. A total of 11 breachers and 4 engineers were followed for up to 17 months. No acute effects or longitudinal deteriorations were identified, but there were some interesting baseline group differences. Upbeat positional nystagmus was common, and correlated (p<0.005) with a history of mild traumatic brain injury (mTBI). Several instructors had abnormally short low-frequency phase leads on rotary chair testing. This study evaluated breaching instructors over a longer test period than any other study, and the results suggest that this population appears to be safe from a vestibular standpoint at the current exposure levels. Upbeat positional nystagmus correlated with a history of mTBI in this population, and this has not been described elsewhere. The data trends also suggest that this nystagmus could be an acute blast effect. However, the reasons for the abnormally short phase leads seen in rotary chair testing are unclear at this time. Further investigation seems warranted. C1 [Littlefield, Philip D.] Walter Reed Natl Mil Med Ctr, Dept Otolaryngol, Bethesda, MD USA. [Pinto, Robin L.; Burrows, Holly L.; Brungart, Douglas S.] Walter Reed Natl Mil Med Ctr, Audiol & Speech Pathol Ctr, Bethesda, MD USA. RP Littlefield, PD (reprint author), Tripler Army Med Ctr, Dept Otolaryngol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM philip.d.littlefield.mil@mail.mil FU U.S. Army Medical Research and Materiel Command, Intramural War Supplemental Program [W81XWH-09-2-0192]; Congressionally Directed Medical Research Program Intramural Traumatic Brain Injury Investigator-Initiated Research Award (Ahroon) [FY07] FX No competing financial interests exist. This research was performed in collaboration with the U.S. Army Aeromedical Research Lab, Fort Rucker, AL. William A. Ahroon, PhD, was the principal investigator of the overall grant supporting it. The grant was through the U.S. Army Medical Research and Materiel Command, Intramural War Supplemental Program, Award Number W81XWH-09-2-0192. This was from the Congressionally Directed Medical Research Program FY07 Intramural Traumatic Brain Injury Investigator-Initiated Research Award (Ahroon). The funding period was September 29, 2009 to May 28, 2014. NR 37 TC 0 Z9 0 U1 3 U2 5 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JAN 1 PY 2016 VL 33 IS 1 BP 71 EP 81 DI 10.1089/neu.2014.3824 PG 11 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA CZ4EW UT WOS:000367057200009 PM 25790248 ER PT J AU Boutte, AM Deng-Bryant, Y Johnson, D Tortella, FC Dave, JR Shear, DA Schmid, KE AF Boutte, Angela M. Deng-Bryant, Ying Johnson, David Tortella, Frank C. Dave, Jitendra R. Shear, Deborah A. Schmid, Kara E. TI Serum Glial Fibrillary Acidic Protein Predicts Tissue Glial Fibrillary Acidic Protein Break-Down Products and Therapeutic Efficacy after Penetrating Ballistic-Like Brain Injury SO JOURNAL OF NEUROTRAUMA LA English DT Article DE biomarker; CsA; GFAP-BDP; neuroprotection; proteolysis; SBDP; serum; TBI ID ALPHA-II-SPECTRIN; C-TERMINAL HYDROLASE; CEREBRAL-ARTERY OCCLUSION; CYCLOSPORINE-A; NEUROSURGICAL INTERVENTION; TRANSFORMING RESEARCH; INTRACRANIAL LESIONS; ALZHEIMERS-DISEASE; CLINICAL KNOWLEDGE; PROTEOMIC ANALYSIS AB Acute traumatic brain injury (TBI) is associated with neurological dysfunction, changes in brain proteins, and increased serum biomarkers. However, the relationship between these brain proteins and serum biomarkers, and the ability of these serum biomarkers to indicate a neuroprotective/therapeutic response, remains elusive. Penetrating ballistic-like brain injury (PBBI) was used to systematically analyze several key TBI biomarkers, glial fibrillary acidic protein (GFAP) and its break-down products (BDPs)ubiquitin C-terminal hydrolase-L1 (UCH-L1), -II spectrin, and -II spectrin BDPs (SBDPs)in brain tissues and serum during an extended acute-subacute time-frame. In addition, neurological improvement and serum GFAP theranostic value was evaluated after neuroprotective treatment. In brain tissues, total GFAP increased more than three-fold 2 to 7 d after PBBI. However, this change was primarily due to GFAP-BDPs which increased to 2.7-4.8 arbitrary units (AU). Alpha-II spectrin was nearly ablated 3 d after PBBI, but somewhat recovered after 7 d. In conjunction with -II spectrin loss, SBDP-145/150 increased approximately three-fold 2 to 7 d after PBBI (vs. sham, p<0.05). UCH-L1 protein levels were slightly decreased 7 d after PBBI but otherwise were unaffected. Serum GFAP was elevated by 3.2- to 8.8-fold at 2 to 4h (vs. sham; p<0.05) and the 4h increase was strongly correlated to 3 d GFAP-BDP abundance (r=0.66; p<0.05). Serum GFAP showed such a strong injury effect that it also was evaluated after therapeutic intervention with cyclosporin A (CsA). Administration of 2.5mg/kg CsA significantly reduced serum GFAP elevation by 22.4-fold 2h after PBBI (vs. PBBI+vehicle; p<0.05) and improved neurological function 1 d post-injury. Serum biomarkers, particularly GFAP, may be correlative tools of brain protein changes and feasible theranostic markers of TBI progression and recovery. C1 [Boutte, Angela M.; Deng-Bryant, Ying; Johnson, David; Tortella, Frank C.; Dave, Jitendra R.; Shear, Deborah A.; Schmid, Kara E.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat Branch, Silver Spring, MD 20910 USA. RP Boutte, AM (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM angela.m.boutte.civ@mail.mil FU Combat Casualty Care Research Program; Congressionally Directed Medical Research Program [W81XWH-12-2-0134] FX The views of the authors do not purport or reflect the position of the Department of the Army or the Department of Defense (para 43, AR 360-5). This research is funded by Combat Casualty Care Research Program and Congressionally Directed Medical Research Program (Contract #: W81XWH-12-2-0134). The authors thank Ms. Shonnette Grant, M.S.; SGT Myint, US Army; SPC Donkor, US Army; Ms. Rebecca Pedersen; and Mr. Francis Bustos for their technical expertise, as well as Dr. Ryan Readnower and Dr. Cartagena for their invaluable advice. NR 51 TC 4 Z9 4 U1 0 U2 3 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JAN 1 PY 2016 VL 33 IS 1 BP 147 EP 156 DI 10.1089/neu.2014.3672 PG 10 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA CZ4EW UT WOS:000367057200017 PM 25789543 ER PT J AU Patterson, AT Kaffenberger, BH Keller, RA Elston, DM AF Patterson, Andrew T. Kaffenberger, Benjamin H. Keller, Richard A. Elston, Dirk M. TI Skin diseases associated with Agent Orange and other organochlorine exposures SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Review DE Agent Orange; chloracne; dioxin exposure; organochlorine; skin disease; veteran; Vietnam; 2,3,7,8-tetrachlorodibenzo-p-dioxin ID OPERATION RANCH HAND; PORPHYRIA-CUTANEA-TARDA; CHEMICAL CORPS VIETNAM; NON-HODGKINS-LYMPHOMA; AIR-FORCE VETERANS; 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN TCDD INTOXICATION; TRICHLOROPHENOL PROCESS ACCIDENT; CHRONIC HEPATIC PORPHYRIA; UNITED-STATES MILITARY; SOFT-TISSUE SARCOMA AB Organochlorine exposure is an important cause of cutaneous and systemic toxicity. Exposure has been associated with industrial accidents, intentional poisoning, and the use of defoliants, such as Agent Orange in the Vietnam War. Although long-term health effects are systematically reviewed by the Institute of Medicine, skin diseases are not comprehensively assessed. This represents an important practice gap as patients can present with cutaneous findings. This article provides a systematic review of the cutaneous manifestations of known mass organochlorine exposures in military and industrial settings with the goal of providing clinically useful recommendations for dermatologists seeing patients inquiring about organochlorine effects. Patients with a new diagnosis of chloracne, porphyria cutanea tarda, cutaneous lymphomas (non-Hodgkin lymphoma), and soft-tissue sarcomas including dermatofibrosarcoma protuberans and leiomyosarcomas should be screened for a history of Vietnam service or industrial exposure. Inconclusive evidence exists for an increased risk of other skin diseases in Vietnam veterans exposed to Agent Orange including benign fatty tumors, melanomas, nonmelanoma skin cancers, milia, eczema, dyschromias, disturbance of skin sensation, and rashes not otherwise specified. Affected veterans should be informed of the uncertain data in those cases. Referral to Department of Veterans Affairs for disability assessment is indicated for conditions with established associations. C1 [Patterson, Andrew T.; Kaffenberger, Benjamin H.] Ohio State Univ, Coll Med, Div Dermatol, Columbus, OH 43212 USA. [Patterson, Andrew T.] US Air Force, San Antonio Mil Med Ctr, San Antonio, TX USA. [Keller, Richard A.] US Air Force, Audie L Murphy Vet Hosp, Dermatol, Washington, DC USA. [Elston, Dirk M.] Ackerman Acad Dermatopathol, New York, NY USA. [Elston, Dirk M.] US Army, New York, NY USA. RP Kaffenberger, BH (reprint author), Ohio State Univ, Dermatol, 915 Olentangy River Rd,Suite 4000, Columbus, OH 43212 USA. EM Benjamin.Kaffenberger@osumc.edu NR 143 TC 0 Z9 0 U1 6 U2 20 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD JAN PY 2016 VL 74 IS 1 BP 143 EP 170 DI 10.1016/j.jaad.2015.05.006 PG 28 WC Dermatology SC Dermatology GA CZ4IF UT WOS:000367066000024 PM 26210237 ER PT J AU Holtsberg, FW Shulenin, S Vu, H Howell, KA Patel, SJ Gunn, B Karim, M Lai, JR Frei, JC Nyakatura, EK Zeitlin, L Douglas, R Fusco, ML Froude, JW Saphire, EO Herbert, AS Wirchnianski, AS Lear-Rooney, CM Alter, G Dye, JM Glass, PJ Warfield, KL Aman, MJ AF Holtsberg, Frederick W. Shulenin, Sergey Hong Vu Howell, Katie A. Patel, Sonal J. Gunn, Bronwyn Karim, Marcus Lai, Jonathan R. Frei, Julia C. Nyakatura, Elisabeth K. Zeitlin, Larry Douglas, Robin Fusco, Marnie L. Froude, Jeffrey W. Saphire, Erica Ollmann Herbert, Andrew S. Wirchnianski, Ariel S. Lear-Rooney, Calli M. Alter, Galit Dye, John M. Glass, Pamela J. Warfield, Kelly L. Aman, M. Javad TI Pan-ebolavirus and Pan-filovirus Mouse Monoclonal Antibodies: Protection against Ebola and Sudan Viruses SO JOURNAL OF VIROLOGY LA English DT Article ID FC-GAMMA-RIII; NONHUMAN-PRIMATES; HEMORRHAGIC-FEVER; INFECTION; DISEASE; MICE; GLYCOPROTEIN; PROPHYLAXIS; AFRICA; MODEL AB The unprecedented 2014-2015 Ebola virus disease (EVD) outbreak in West Africa has highlighted the need for effective therapeutics against filoviruses. Monoclonal antibody (MAb) cocktails have shown great potential as EVD therapeutics; however, the existing protective MAbs are virus species specific. Here we report the development of pan-ebolavirus and pan-filovirus antibodies generated by repeated immunization of mice with filovirus glycoproteins engineered to drive the B cell responses toward conserved epitopes. Multiple pan-ebolavirus antibodies were identified that react to the Ebola, Sudan, Bundibugyo, and Reston viruses. A pan-filovirus antibody that was reactive to the receptor binding regions of all filovirus glycoproteins was also identified. Significant postexposure efficacy of several MAbs, including a novel antibody cocktail, was demonstrated. For the first time, we report cross-neutralization and in vivo protection against two highly divergent filovirus species, i.e., Ebola virus and Sudan virus, with a single antibody. Competition studies indicate that this antibody targets a previously unrecognized conserved neutralizing epitope that involves the glycan cap. Mechanistic studies indicated that, besides neutralization, innate immune cell effector functions may play a role in the antiviral activity of the antibodies. Our findings further suggest critical novel epitopes that can be utilized to design effective cocktails for broad protection against multiple filovirus species. C1 [Holtsberg, Frederick W.; Shulenin, Sergey; Hong Vu; Howell, Katie A.; Patel, Sonal J.; Douglas, Robin; Warfield, Kelly L.; Aman, M. Javad] Integrated BioTherapeut Inc, Gaithersburg, MD 20878 USA. [Gunn, Bronwyn; Karim, Marcus; Alter, Galit] Ragon Inst Massachusetts Gen Hosp Massachusetts I, Boston, MA USA. [Lai, Jonathan R.; Frei, Julia C.; Nyakatura, Elisabeth K.] Albert Einstein Coll Med, New York, NY USA. [Zeitlin, Larry] Mapp Biopharmaceut, San Diego, CA USA. [Fusco, Marnie L.; Saphire, Erica Ollmann] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA USA. [Froude, Jeffrey W.; Herbert, Andrew S.; Wirchnianski, Ariel S.; Lear-Rooney, Calli M.; Dye, John M.; Glass, Pamela J.] US Army Med Res Inst Infect Dis, Frederick, MD USA. RP Aman, MJ (reprint author), Integrated BioTherapeut Inc, Gaithersburg, MD 20878 USA. EM javad@integratedbiotherapeutics.com FU HHS \ NIH \ National Institute of Allergy and Infectious Diseases (NIAID) [R01 AI067927, U19 AI109762]; DOD \ Defense Threat Reduction Agency (DTRA) [HD-TRA1-13-C-0015] FX HHS vertical bar NIH vertical bar National Institute of Allergy and Infectious Diseases (NIAID) provided funding to Erica Oilmann Saphire under grant numbers R01 AI067927 and U19 AI109762. DOD vertical bar Defense Threat Reduction Agency (DTRA) provided funding to M. Javad Aman under grant number HD-TRA1-13-C-0015. NR 49 TC 11 Z9 11 U1 7 U2 17 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X EI 1098-5514 J9 J VIROL JI J. Virol. PD JAN PY 2016 VL 90 IS 1 BP 266 EP 278 DI 10.1128/JVI.02171-15 PG 13 WC Virology SC Virology GA CZ1XK UT WOS:000366899000024 PM 26468533 ER PT J AU Keck, ZY Enterlein, SG Howell, KA Vu, H Shulenin, S Warfield, KL Froude, JW Araghi, N Douglas, R Biggins, J Lear-Rooney, CM Wirchnianski, AS Lau, P Wang, Y Herbert, AS Dye, JM Glass, PJ Holtsberg, FW Foung, SKH Aman, MJ AF Keck, Zhen-Yong Enterlein, Sven G. Howell, Katie A. Hong Vu Shulenin, Sergey Warfield, Kelly L. Froude, Jeffrey W. Araghi, Nazli Douglas, Robin Biggins, Julia Lear-Rooney, Calli M. Wirchnianski, Ariel S. Lau, Patrick Wang, Yong Herbert, Andrew S. Dye, John M. Glass, Pamela J. Holtsberg, Frederick W. Foung, Steven K. H. Aman, M. Javad TI Macaque Monoclonal Antibodies Targeting Novel Conserved Epitopes within Filovirus Glycoprotein SO JOURNAL OF VIROLOGY LA English DT Article ID EBOLA-VIRUS INFECTION; NIEMANN-PICK C1; NONHUMAN-PRIMATES; GUINEA-PIGS; B-CELLS; HEMORRHAGIC-FEVER; PARTICLES PROTECT; MOUSE MODEL; MICE; PROPHYLAXIS AB Filoviruses cause highly lethal viral hemorrhagic fever in humans and nonhuman primates. Current immunotherapeutic options for filoviruses are mostly specific to Ebola virus (EBOV), although other members of Filoviridae such as Sudan virus (SUDV), Bundibugyo virus (BDBV), and Marburg virus (MARV) have also caused sizeable human outbreaks. Here we report a set of pan-ebolavirus and pan-filovirus monoclonal antibodies (MAbs) derived from cynomolgus macaques immunized repeatedly with a mixture of engineered glycoproteins (GPs) and virus-like particles (VLPs) for three different filovirus species. The antibodies recognize novel neutralizing and nonneutralizing epitopes on the filovirus glycoprotein, including conserved conformational epitopes within the core regions of the CP1 subunit and a novel linear epitope within the glycan cap. We further report the first filovirus antibody binding to a highly conserved epitope within the fusion loop of ebolavirus and marburgvirus species. One of the antibodies binding to the core CP1 region of all ebolavirus species and with lower affinity to MARV GP cross neutralized both SUDV and EBOV, the most divergent ebolavirus species. In a mouse model of EBOV infection, this antibody provided 100% protection when administered in two doses and partial, but significant, protection when given once at the peak of viremia 3 days postinfection. Furthermore, we describe novel cocktails of antibodies with enhanced protective efficacy compared to individual MAbs. In summary, the present work describes multiple novel, cross-reactive filovirus epitopes and innovative combination concepts that challenge the current therapeutic models. C1 [Enterlein, Sven G.; Howell, Katie A.; Hong Vu; Shulenin, Sergey; Warfield, Kelly L.; Araghi, Nazli; Douglas, Robin; Biggins, Julia; Holtsberg, Frederick W.; Aman, M. Javad] Integrated BioTherapeut Inc, Gaithersburg, MD 20878 USA. [Keck, Zhen-Yong; Lau, Patrick; Wang, Yong; Foung, Steven K. H.] Stanford Univ, Dept Pathol, Stanford, CA 94305 USA. [Froude, Jeffrey W.; Lear-Rooney, Calli M.; Wirchnianski, Ariel S.; Herbert, Andrew S.; Dye, John M.; Glass, Pamela J.] US Army Med Res Inst Infect Dis, Frederick, MD USA. RP Aman, MJ (reprint author), Integrated BioTherapeut Inc, Gaithersburg, MD 20878 USA. EM javad@integratedbiotherapeutics.com FU HHS \ NIH \ National Institute of Allergy and Infectious Diseases (NIAID) [R43AI098178]; DOD \ Defense Threat Reduction Agency (DTRA) [HDTRA1-13-C-0015] FX HHS vertical bar NIH vertical bar National Institute of Allergy and Infectious Diseases (NIAID) provided funding to Sven G Enterlein under grant number R43AI098178. DOD vertical bar Defense Threat Reduction Agency (DTRA) provided funding to M. Javad Aman under grant number HDTRA1-13-C-0015. NR 48 TC 5 Z9 5 U1 3 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X EI 1098-5514 J9 J VIROL JI J. Virol. PD JAN PY 2016 VL 90 IS 1 BP 279 EP 291 DI 10.1128/JVI.02172-15 PG 13 WC Virology SC Virology GA CZ1XK UT WOS:000366899000025 PM 26468532 ER PT J AU Devita, P Fellin, RE Seay, JF Ip, E Stavro, N Messier, SP AF Devita, Paul Fellin, Rebecca E. Seay, Joseph F. Ip, Edward Stavro, Nicole Messier, Stephen P. TI The Relationships between Age and Running Biomechanics SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE OLDER RUNNERS; JOINT TORQUE; POWER; AGING; GAIT ID GROUND REACTION FORCES; PHYSICAL-ACTIVITY; LOWER-EXTREMITY; MORPHOLOGICAL PROPERTIES; MUSCLE STRENGTH; MASTERS RUNNERS; ELDERLY RUNNERS; WOMEN; DISTANCE; MEN AB Running has high injury rates, especially among older runners. Most aging literature compares young with old runners without accounting for the progression of biomechanics throughout the lifespan. We used age as a continuous variable to investigate the continuum of age-related gait adaptations in running along with determining the chronology and rate of these adaptations. Purpose This study aimed to identify the relations among age and selected running biomechanics throughout the range of 18-60 yr. Methods Experienced (n = 110) healthy runners (male, 54%) provided informed consent and ran at their training pace while motion and force data were captured. Kinematics, ground reaction forces (GRF), and lower limb joint torques and powers were correlated with age using Pearson product-moment correlations and linear regression. Results Running velocity was inversely related to age (r = -0.27, P = 0.005) because of decreased stride length (r = -0.25, P = 0.008) but not rate. Peak vertical GRF (r = -0.23, P = 0.016) and peak horizontal propulsive GRF decreased with age (r = -0.38, P < 0.0001). Peak ankle torque (r = -0.32, P = 0.0007) and peak negative (r = 0.34, P = 0.0003) and positive (r = -0.37, P < 0.0001) ankle power decreased with age. Age-based regression equations and per-year reductions in all variables significantly related to age are reported. Conclusions Data support previous work showing lower GRF, stride length, and velocity in old runners. Results are novel in showing the rate of decline in running biomechanics on a per-year basis and that mechanical reductions at the ankle but not at the hip or knee were correlated with age, confirming a previous observation of biomechanical plasticity with age showing reduced ankle but not hip function in gait. C1 [Devita, Paul] E Carolina Univ, Dept Kinesiol, Greenville, NC 27858 USA. [Fellin, Rebecca E.; Seay, Joseph F.] US Army, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Ip, Edward] Wake Forest Sch Med, Dept Biostat Sci, Winston Salem, NC USA. [Ip, Edward] Wake Forest Sch Med, Dept Social Sci & Hlth Policy, Winston Salem, NC USA. [Stavro, Nicole; Messier, Stephen P.] Wake Forest Univ, Dept Hlth & Exercise Sci, Winston Salem, NC 27109 USA. RP Devita, P (reprint author), E Carolina Univ, Dept Kinesiol, 332 Ward Sports Med Bldg, Greenville, NC 27858 USA. EM devitap@ecu.edu FU USAMRAA (US Army) [W81XWH-10-1-0455]; US Army Research Institute of Environmental Medicine FX This study was sponsored by grant W81XWH-10-1-0455, USAMRAA (US Army). Research supported partly by an appointment to the Postgraduate Research Participation Program (REF) funded by the US Army Research Institute of Environmental Medicine and administered by Oak Ridge Institute for Science and Engineering. The authors report no conflict of interest. Citations of commercial organizations and trade names in this report do not constitute an official Department of the Army endorsement or approval of the products or services of these organizations. The results of the present study do not constitute endorsement by the American College of Sports Medicine. NR 49 TC 4 Z9 4 U1 5 U2 19 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD JAN PY 2016 VL 48 IS 1 BP 98 EP 106 DI 10.1249/MSS.0000000000000744 PG 9 WC Sport Sciences SC Sport Sciences GA CY7LO UT WOS:000366590100014 PM 26258853 ER PT J AU Poff, NL Brown, CM Grantham, T Matthews, JH Palmer, MA Spence, CM Wilby, RL Haasnoot, M Mendoza, GF Dominique, KC Baeza, A AF Poff, N. LeRoy Brown, Casey M. Grantham, TheodoreE. Matthews, John H. Palmer, Margaret A. Spence, Caitlin M. Wilby, Robert L. Haasnoot, Marjolijn Mendoza, Guillermo F. Dominique, Kathleen C. Baeza, Andres TI Sustainable water management under future uncertainty with eco-engineering decision scaling SO NATURE CLIMATE CHANGE LA English DT Article ID GENERAL-CIRCULATION MODELS; CLIMATE-CHANGE; ECOLOGICAL CONSEQUENCES; ENVIRONMENTAL FLOWS; BASIC PRINCIPLES; CHANGING WORLD; UNITED-STATES; BIODIVERSITY; RESILIENCE; ADAPTATION AB Managing freshwater resources sustainably under future climatic and hydrological uncertainty poses novel challenges. Rehabilitation of ageing infrastructure and construction of new dams are widely viewed as solutions to diminish climate risk, but attaining the broad goal of freshwater sustainability will require expansion of the prevailing water resources management paradigm beyond narrow economic criteria to include socially valued ecosystem functions and services. We introduce a new decision framework, eco-engineering decision scaling (EEDS), that explicitly and quantitatively explores trade-offs in stake-holder-defined engineering and ecological performance metrics across a range of possible management actions under unknown future hydrological and climate states. We illustrate its potential application through a hypothetical case study of the Iowa River, USA. EEDS holds promise as a powerful framework for operationalizing freshwater sustainability under future hydrological uncertainty by fostering collaboration across historically conflicting perspectives of water resource engineering and river conservation ecology to design and operate water infrastructure for social and environmental benefits. C1 [Poff, N. LeRoy] Colorado State Univ, Dept Biol, Ft Collins, CO 80523 USA. [Poff, N. LeRoy; Spence, Caitlin M.] Colorado State Univ, Grad Degree Program Ecol, Ft Collins, CO 80523 USA. [Brown, Casey M.; Spence, Caitlin M.] Univ Massachusetts, Civil & Environm Engn, Amherst, MA 01003 USA. [Grantham, TheodoreE.] US Geol Survey, Ft Collins Sci Ctr, Ft Collins, CO 80526 USA. [Matthews, John H.] Alliance Global Water Adaptat, Orlando, FL USA. [Palmer, Margaret A.] Univ Maryland, Natl Socioenvironm Synth Ctr, Annapolis, MD 21401 USA. [Wilby, Robert L.] Univ Loughborough, Dept Geog, Loughborough LE11 3TU, Leics, England. [Haasnoot, Marjolijn] Deltares, Dept Scenarios & Policy Anal, NL-2600 MH Delft, Netherlands. [Haasnoot, Marjolijn] Delft Univ Technol, Fac Technol Policy & Management, NL-2600 GA Delft, Netherlands. [Mendoza, Guillermo F.] US Army Corps Engineers, Inst Water Resources, Alexandria, VA 22315 USA. [Dominique, Kathleen C.] Org Econ Cooperat & Dev, F-75775 Paris, France. [Baeza, Andres] Natl Socioenvironm Synth Ctr, Annapolis, MD 21401 USA. RP Poff, NL (reprint author), Colorado State Univ, Dept Biol, Campus Mail 1878, Ft Collins, CO 80523 USA. EM NLeRoy.Poff@colostate.edu OI Haasnoot, Marjolijn/0000-0002-9062-4698; matthews, john/0000-0002-7005-2661 FU NSF CAREER Award [CBET-1054762]; National Socio-Environmental Synthesis Center (SESYNC) under National Science Foundation [DBI-1052875] FX We acknowledge S. Steinschneider for developing the stochastic weather generator for the Iowa River Basin; S. Wi for the VIC hydrologic model development; D. LeFever for support in developing the reservoir systems model; and R. Olsen for his help in providing hydraulic modelling tools and economic information for the Coralville Lake flood control system. Special thanks to P. Clark for artwork in Fig. 1. Additional support for C.M.B. and C.M.S was provided by the NSF CAREER Award (CBET-1054762). The views in this article are those of the authors and do not necessarily represent the views of the OECD or its member countries. This article has been peer reviewed and approved for publication consistent with USGS Fundamental Science Practices (http://pubs.usgs.gov/circ/1367/) and we thank J. Friedman of the USGS for his constructive comments. Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the U.S. Government. This paper resulted from a synthesis project funded by the National Socio-Environmental Synthesis Center (SESYNC) under National Science Foundation Award #DBI-1052875. NR 90 TC 17 Z9 17 U1 26 U2 76 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1758-678X EI 1758-6798 J9 NAT CLIM CHANGE JI Nat. Clim. Chang. PD JAN PY 2016 VL 6 IS 1 BP 25 EP 34 DI 10.1038/NCLIMATE2765 PG 10 WC Environmental Sciences; Environmental Studies; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA CZ3UZ UT WOS:000367030800014 ER PT J AU Tarney, CM AF Tarney, Christopher M. TI Association of Spouse Deployment on Pregnancy Outcomes in a US Military Population Reply SO OBSTETRICS AND GYNECOLOGY LA English DT Letter C1 [Tarney, Christopher M.] Womack Army Med Ctr, Dept Obstet & Gynecol, Ft Bragg, NC 28307 USA. RP Tarney, CM (reprint author), Womack Army Med Ctr, Dept Obstet & Gynecol, Ft Bragg, NC 28307 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD JAN PY 2016 VL 127 IS 1 BP 164 EP 164 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA CZ2DG UT WOS:000366914700018 PM 26695570 ER PT J AU Castellani, JW Tipton, MJ AF Castellani, John W. Tipton, Michael J. TI Cold Stress Effects on Exposure Tolerance and Exercise Performance SO COMPREHENSIVE PHYSIOLOGY LA English DT Article ID REFLEX CUTANEOUS VASOCONSTRICTION; HUMAN THERMOREGULATORY RESPONSES; PROLONGED INTERMITTENT WALKING; CHILL EQUIVALENT TEMPERATURE; SURVIVAL-TIME PREDICTION; BROWN ADIPOSE-TISSUE; BODY HEAT-CONTENT; WATER IMMERSION; INITIAL RESPONSES; PHYSIOLOGICAL-RESPONSES AB Cold weather can have deleterious effects on health, tolerance, and performance. This paper will review the physiological responses and external factors that impact cold tolerance and physical performance. Tolerance is defined as the ability to withstand cold stress with minimal changes in physiological strain. Physiological and pathophysiological responses to short-term (cold shock) and long-term cold water and air exposure are presented. Factors (habituation, anthropometry, sex, race, and fitness) that influence cold tolerance are also reviewed. The impact of cold exposure on physical performance, especially aerobic performance, has not been thoroughly studied. The few studies that have been done suggest that aerobic performance is degraded in cold environments. Potential physiological mechanisms (decreases in deep body and muscle temperature, cardiovascular, and metabolism) are discussed. Likewise, strength and power are also degraded during cold exposure, primarily through a decline in muscle temperature. The review also discusses the concept of thermoregulatory fatigue, a reduction in the thermal effector responses of shivering and vasoconstriction, as a result of multistressor factors, including exhaustive exercise. (C) 2016 American Physiological Society. C1 [Castellani, John W.] US Army Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA 01760 USA. [Tipton, Michael J.] Univ Portsmouth, Dept Exercise & Sport Sci, Extreme Environm Lab, Portsmouth, Hants, England. RP Castellani, JW (reprint author), US Army Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA 01760 USA. EM john.w.castellani.civ@mail.mil NR 279 TC 3 Z9 3 U1 25 U2 71 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 2040-4603 J9 COMPR PHYSIOL JI Compr. Physiol. PD JAN PY 2016 VL 6 IS 1 BP 443 EP 469 DI 10.1002/cphy.c140081 PG 27 WC Physiology SC Physiology GA CY8GS UT WOS:000366647400015 PM 26756639 ER PT J AU Murillo, JSR Mohamed, A Hodo, W Mohan, RV Rajendran, A Valisetty, R AF Murillo, John S. Rivas Mohamed, Ahmed Hodo, Wayne Mohan, Ram V. Rajendran, A. Valisetty, R. TI Computational modeling of shear deformation and failure of nanoscale hydrated calcium silicate hydrate in cement paste: Calcium silicate hydrate Jennite SO INTERNATIONAL JOURNAL OF DAMAGE MECHANICS LA English DT Article DE Material chemistry level modeling; cement; molecular dynamics; multi-scale modeling; deformation and failure; calcium silicate hydrate ID C-S-H; PORTLAND-CEMENT; ELASTIC PROPERTIES; TRICALCIUM SILICATE; BLENDS; SLAG AB Calcium silicate hydrate Jennite is a molecular structure commonly accepted as a representation of the complex calcium silicate hydrate gel formed during the hydration of typical Portland cement. In this paper, the behavior of nanoscale calcium silicate hydrate Jennite under shear deformation was investigated using molecular dynamics simulations. Computational samples representing the nanoscale structure of calcium silicate hydrate Jennite were subjected to shear deformation in order to investigate not only their mechanical properties but also their deformation behavior. The simulation results indicated that the nanoscale calcium silicate hydrate Jennite under shear deformation displays a linear elastic behavior up to shear stress of approximately 1.0GPa, and shear deformation of about 0.08 radians, after which point yielding and plastic deformation occurs. The shear modulus determined from the simulations was 11.2 +/- 0.7GPa. The deformation-induced displacements in molecular structures were analyzed dividing the system in regions representing calcium oxide layers. The displacement/deformation of the layers of calcium oxide forming the structure of nanoscale calcium silicate hydrate Jennite was analyzed. The non-linear stress-strain behavior in the molecular structure was attributed to a non-linear increase in the displacement due to sliding of the calcium oxide layers on top of each other with higher shearing. These results support the idea that by controlling the chemical reactions, the tailored morphologies can be used to increase the interlinking between the calcium oxide layers, thus minimizing the shearing of the layers and leading to molecular structures that can withstand larger deformation and have improved failure behavior. C1 [Murillo, John S. Rivas; Mohamed, Ahmed; Mohan, Ram V.] North Carolina A&T State Univ, Joint Sch Nanosci & Nanoengn, Nanoengn Dept, Greensboro, NC 27401 USA. [Hodo, Wayne] Engn Res & Dev Ctr, Vicksburg, MS USA. [Rajendran, A.] Univ Mississippi, Dept Mech Engn, Oxford, MS USA. [Valisetty, R.] US Army Res Lab, Baltimore, MD USA. RP Mohan, RV (reprint author), North Carolina A&T State Univ, Joint Sch Nanosci & Nanoengn, Nanoengn Dept, 2907 E Lee St, Greensboro, NC 27401 USA. EM rvmohan@ncat.edu FU U.S. Army Research Office [W911NF-11-2-0043]; U.S. Army Engineering Research and Development Center's Military Engineering Basic/Applied "MMFP" Research Program FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The authors from North Carolina A&T State University, Greensboro, and University of Mississippi, Oxford, acknowledge the support by the U.S. Army Research Office under a cooperative agreement award contract No. W911NF-11-2-0043 (Program Manager: Dr. Joseph Myers), and the U.S. Army Engineering Research and Development Center's Military Engineering Basic/Applied "MMFP" Research Program. NR 36 TC 0 Z9 0 U1 3 U2 10 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1056-7895 EI 1530-7921 J9 INT J DAMAGE MECH JI Int. J. Damage Mech. PD JAN PY 2016 VL 25 IS 1 SI SI BP 98 EP 114 DI 10.1177/1056789515580184 PG 17 WC Materials Science, Multidisciplinary; Mechanics SC Materials Science; Mechanics GA CY7SM UT WOS:000366609200008 ER PT J AU Servinsky, MD Terrell, JL Tsao, CY Wu, HC Quan, DN Zargar, A Allen, PC Byrd, CM Sund, CJ Bentley, WE AF Servinsky, Matthew D. Terrell, Jessica L. Tsao, Chen-Yu Wu, Hsuan-Chen Quan, David N. Zargar, Amin Allen, Patrick C. Byrd, Christopher M. Sund, Christian J. Bentley, William E. TI Directed assembly of a bacterial quorum SO ISME JOURNAL LA English DT Article ID ESCHERICHIA-COLI K-12; GENE-EXPRESSION; VIBRIO-HARVEYI; BIOFILM FORMATION; AUTOINDUCER AI-2; LUXS; COMMUNICATION; DENSITY; REGULATORS; SYSTEM AB Many reports have elucidated the mechanisms and consequences of bacterial quorum sensing (QS), a molecular communication system by which bacterial cells enumerate their cell density and organize collective behavior. In few cases, however, the numbers of bacteria exhibiting this collective behavior have been reported, either as a number concentration or a fraction of the whole. Not all cells in the population, for example, take on the collective phenotype. Thus, the specific attribution of the postulated benefit can remain obscure. This is partly due to our inability to independently assemble a defined quorum, for natural and most artificial systems the quorum itself is a consequence of the biological context (niche and signaling mechanisms). Here, we describe the intentional assembly of quantized quorums. These are made possible by independently engineering the autoinducer signal transduction cascade of Escherichia coli (E. coli) and the sensitivity of detector cells so that upon encountering a particular autoinducer level, a discretized sub-population of cells emerges with the desired phenotype. In our case, the emergent cells all express an equivalent amount of marker protein, DsRed, as an indicator of a specific QS-mediated activity. The process is robust, as detector cells are engineered to target both large and small quorums. The process takes about 6 h, irrespective of quorum level. We demonstrate sensitive detection of autoinducer-2 (AI-2) as an application stemming from quantized quorums. We then demonstrate sub-population partitioning in that AI-2-secreting cells can 'call' groups neighboring cells that 'travel' and establish a QS-mediated phenotype upon reaching the new locale. C1 [Servinsky, Matthew D.; Allen, Patrick C.; Byrd, Christopher M.; Sund, Christian J.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD USA. [Terrell, Jessica L.; Tsao, Chen-Yu; Wu, Hsuan-Chen; Quan, David N.; Zargar, Amin; Byrd, Christopher M.; Bentley, William E.] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA. [Terrell, Jessica L.; Tsao, Chen-Yu; Wu, Hsuan-Chen; Quan, David N.; Zargar, Amin; Byrd, Christopher M.; Bentley, William E.] Univ Maryland, Inst Biosci & Biotechnol Res, College Pk, MD 20742 USA. RP Bentley, WE (reprint author), Univ Maryland, Fischell Dept Bioengn, 2330 Jeong H Kim Engn Bldg, College Pk, MD 20742 USA. EM bentley@umd.edu OI WU, HSUAN-CHEN/0000-0002-7837-1333 FU Defense Threat Reduction Agency (DTRA) [HDTRA1-13-1-0037]; National Science Foundation [CBET 1264509, CBET 1160005]; RW Deutsch Foundation FX We acknowledge support of the Defense Threat Reduction Agency (DTRA, HDTRA1-13-1-0037), the National Science Foundation (CBET 1264509 & CBET 1160005) and the RW Deutsch Foundation. NR 54 TC 6 Z9 6 U1 7 U2 37 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1751-7362 EI 1751-7370 J9 ISME J JI ISME J. PD JAN PY 2016 VL 10 IS 1 BP 158 EP 169 DI 10.1038/ismej.2015.89 PG 12 WC Ecology; Microbiology SC Environmental Sciences & Ecology; Microbiology GA CY8PR UT WOS:000366671300016 PM 26046256 ER PT J AU Sailasuta, N Ananworanich, J Lerdlum, S Sithinamsuwan, P Fletcher, JLK Tipsuk, S Pothisri, M Jadwattanakul, T Jirajariyavej, S Chalermchai, T Catella, S Busovaca, E Desai, A Paul, R Valcour, V AF Sailasuta, Napapon Ananworanich, Jintanat Lerdlum, Sukalaya Sithinamsuwan, Pasiri Fletcher, James L. K. Tipsuk, Somporn Pothisri, Mantana Jadwattanakul, Tanate Jirajariyavej, Supunnee Chalermchai, Thep Catella, Stephanie Busovaca, Edgar Desai, Akash Paul, Robert Valcour, Victor CA SEARCH 011 Study Grp TI Neuronal-Glia Markers by Magnetic Resonance Spectroscopy in HIV Before and After Combination Antiretroviral Therapy SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE HIV; magnetic resonance spectroscopy; cognitive disorders ID CEREBRAL METABOLITE ABNORMALITIES; HUMAN-IMMUNODEFICIENCY-VIRUS; GAMMA-AMINOBUTYRIC-ACID; PROTON MR SPECTROSCOPY; AIDS DEMENTIA COMPLEX; TE-AVERAGED PRESS; NEUROCOGNITIVE DISORDERS; POSITIVE PATIENTS; INFECTED PATIENTS; FRONTAL-LOBE AB Objective:Combination antiretroviral therapy (cART) can suppress plasma HIV RNA to undetectable levels; yet reports indicate persistent HIV-associated neurocognitive disorders (HAND) among treated individuals. We sought to investigate imaging correlates of incomplete cognitive recovery among individuals with chronic HIV.Methods:We used single voxel proton magnetic resonance spectroscopy in 4 regions of the brain to measure changes in neuronal and glia biomarkers in cART-naive subjects before (n = 59, 27 with HAND) and after 12 months of cART.Results:At baseline, we observed elevated total choline (CHO) in the basal ganglia (BG, P = 0.002) and in the posterior cingulate gyrus (PCG, P = 0.022) associated with HIV infection. Myo-inositol (MI) was elevated in the frontal white matter (FWM, P = 0.040). N-acetylaspartate was elevated in the BG (P = 0.047). Using a mixed model approach among all HIV-infected individuals, at 6 months, we observed decreased n- acetylaspartate in FWM (P = 0.031), decreased creatine in PCG (P = 0.026) and increased MI in frontal gray matter (FGM, P = 0.023). At 12 months, we observed an increase in BG MI (P = 0.038) and in FGM (P = 0.021). Compared to those with normal cognition, HAND cases had higher FGM MI (P = 0.014) at baseline. At 12 months, individuals that remained cognitively impaired compared with those without HAND exhibited elevated CHO in the PCG (P = 0.018) and decreased glutamate in both FWM (P = 0.027) and BG (P = 0.013).Conclusions:cART started during chronic HIV is associated with reduced neuronal-glia and inflammatory markers. Alterations in CHO are noted among individuals who remain impaired after 12 months of cART. C1 [Sailasuta, Napapon] Univ Hawaii, Dept Trop Med, Honolulu, HI 96822 USA. [Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Ananworanich, Jintanat; Fletcher, James L. K.; Tipsuk, Somporn; Chalermchai, Thep] Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, Thailand. [Lerdlum, Sukalaya; Pothisri, Mantana] Chulalongkorn Univ, Fac Med, Dept Radiol, Bangkok 10330, Thailand. [Sithinamsuwan, Pasiri] Phramongkutklao Hosp, Div Neurol, Dept Med, Bangkok, Thailand. [Jadwattanakul, Tanate] Queen Savang Vadhana Mem Hosp, Chomburi, Thailand. [Jirajariyavej, Supunnee] Taksin Hosp, Bangkok, Thailand. [Catella, Stephanie; Busovaca, Edgar; Desai, Akash; Valcour, Victor] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA USA. [Paul, Robert] Univ Missouri, Dept Psychol, Missouri Inst Mental Hlth, St Louis, MO 63121 USA. RP Valcour, V (reprint author), UCSF, Sandler Neurosci Ctr, Memory & Aging Ctr, Room 192C,675 Nelson Rising Lane, San Francisco, CA 94158 USA. EM vvalcour@memory.ucsf.edu FU National Institute of Neurological Disorders and Stroke of the National Institutes of Health [R01 NS061696, R01 NS053359] FX Supported by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health under Awards Number R01 NS061696 and R01 NS053359. NR 58 TC 1 Z9 1 U1 3 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD JAN 1 PY 2016 VL 71 IS 1 BP 24 EP 30 DI 10.1097/QAI.0000000000000779 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CY9GL UT WOS:000366715300004 PM 26258565 ER PT J AU Echevarria, A Zaghi, AE Chiarito, V Christenson, R Woodson, S AF Echevarria, Alicia Zaghi, Arash E. Chiarito, Vincent Christenson, Richard Woodson, Stanley TI Experimental Comparison of the Performance and Residual Capacity of CFFT and RC Bridge Columns Subjected to Blasts SO JOURNAL OF BRIDGE ENGINEERING LA English DT Article DE Residual capacity; Blast overpressure confinement; Analytical simulation ID HIGH-STRENGTH CONCRETE; REINFORCED POLYMER TUBES; FILLED STEEL TUBE; SEISMIC PERFORMANCE; CONFINED CONCRETE; COMPOSITE TUBES; FRP; BEHAVIOR; PIERS; MODEL AB The blast performance of concrete-filled fiber-reinforced polymer (FRP) tube (CFFT) bridge columns was studied through a two-phase study comprised of blast and residual axial capacity experiments. Two one-fifth-scale CFFT columns and two one-fifth-scale conventional RC columns having comparable flexural capacities were subjected to distinct levels of explosive loading, causing damage but not complete failure. The blast resilience of the damaged columns was quantified by measuring the residual axial capacity of each column. The damaged CFFT columns exhibited superior strength and ductility retention compared with the damaged RC columns. Additionally, the damaged CFFT columns demonstrated a more predictable axial compressive mode of failure because the exterior FRP tube resisted the shear crack initiation observed in the damaged RC columns. (c) 2015 American Society of Civil Engineers. C1 [Echevarria, Alicia] HNTB Corp, Newark, NJ 07102 USA. [Echevarria, Alicia; Zaghi, Arash E.; Christenson, Richard] Univ Connecticut, Dept Civil & Environm Engn, Storrs, CT 06269 USA. [Chiarito, Vincent; Woodson, Stanley] US Army, Engineer Res & Dev Ctr, Corps Engineers, Vicksburg, MS 39180 USA. RP Echevarria, A (reprint author), HNTB Corp, 2 Gateway Ctr,Suite 1203, Newark, NJ 07102 USA. EM alicia.echevarria@engr.uconn.edu RI Esmaili Zaghi, Arash/K-1023-2014 OI Esmaili Zaghi, Arash/0000-0003-2246-2911 FU U.S. Department of Homeland Security under the DHS HS-STEM Career Development Grant [2008-ST-061-TS002]; National Transportation Security Center of Excellence (NTSCOE) -Department of Homeland Security Centers of Excellence (COE) grant program FX This material is based on work supported by the U.S. Department of Homeland Security under the DHS HS-STEM Career Development Grant Award Number 2008-ST-061-TS002. Funding for the experimental work was also supplied by the National Transportation Security Center of Excellence (NTSCOE) funded by the Department of Homeland Security Centers of Excellence (COE) grant program, administered through the DHS Science and Technology Directorate (S&T) Office of University Programs (OUP). The views and conclusions contained in this document are those of the authors and should not be interpreted as necessarily representing the official policies, either expressed or implied, of the U.S. Department of Homeland Security. Strong support from Prof. Michael Accorsi as PI of the HS-STEM Program is greatly appreciated. Jared Minor, Larry Garrett, Clifford Grey, Arnette Nash, and many others from USACE-ERDC are thanked for the assistance they provided to make these blast tests possible. Special thanks to Matt Smith of National Oilwell Varco for donating the FRP tubes, and Peter Glaude and Serge Doyan for their machining and fabrication work. Also, the assistance provided by Masoud Mehrraoufi and Kevin Zmetra during construction and axial capacity testing is very much appreciated. Permission to publish was granted by Director, Geotechnical & Structures Laboratory. NR 63 TC 1 Z9 1 U1 5 U2 16 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1084-0702 EI 1943-5592 J9 J BRIDGE ENG JI J. Bridge Eng. PD JAN PY 2016 VL 21 IS 1 AR 04015026 DI 10.1061/(ASCE)BE.1943-5592.0000762 PG 15 WC Engineering, Civil SC Engineering GA CY8HP UT WOS:000366649700001 ER PT J AU Cho, H Choi, KK Lee, I Lamb, D AF Cho, Hyunkyoo Choi, K. K. Lee, Ikjin Lamb, David TI Design Sensitivity Method for Sampling-Based RBDO With Varying Standard Deviation SO JOURNAL OF MECHANICAL DESIGN LA English DT Article DE RBDO; varying standard deviation; sampling-based RBDO; score function; tolerance of input random variable ID RELIABILITY ASSESSMENT METHOD; SEQUENTIAL OPTIMIZATION AB Conventional reliability-based design optimization (RBDO) uses the mean of input random variable as its design variable; and the standard deviation (STD) of the random variable is a fixed constant. However, the constant STD may not correctly represent certain RBDO problems well, especially when a specified tolerance of the input random variable is present as a percentage of the mean value. For this kind of design problem, the STD of the input random variable should vary as the corresponding design variable changes. In this paper, a method to calculate the design sensitivity of the probability of failure for RBDO with varying STD is developed. For sampling-based RBDO, which uses Monte Carlo simulation (MCS) for reliability analysis, the design sensitivity of the probability of failure is derived using a first-order score function. The score function contains the effect of the change in the STD in addition to the change in the mean. As copulas are used for the design sensitivity, correlated input random variables also can be used for RBDO with varying STD. Moreover, the design sensitivity can be calculated efficiently during the evaluation of the probability of failure. Using a mathematical example, the accuracy and efficiency of the developed design sensitivity method are verified. The RBDO result for mathematical and physical problems indicates that the developed method provides accurate design sensitivity in the optimization process. C1 [Cho, Hyunkyoo] Univ Iowa, Dept Mech & Ind Engn, Engn Res Facil 218, Iowa City, IA 52242 USA. [Choi, K. K.] Univ Iowa, Dept Mech & Ind Engn, Mem ASME, Iowa City, IA 52242 USA. [Lee, Ikjin] Korea Adv Inst Sci & Technol KAIST, Dept Mech Engn, Daejeon 305701, South Korea. [Lamb, David] US Army, RDECOM TARDEC, Warren, MI 48397 USA. RP Choi, KK (reprint author), Univ Iowa, Dept Mech & Ind Engn, Mem ASME, 2134 SC, Iowa City, IA 52242 USA. EM hyunkyoo-cho@uiowa.edu; kkchoi@engineering.uiowa.edu; ikjin.lee@kaist.ac.kr; david.a.lamb40.civ@mail.mil RI Lee, IkJin/I-4722-2013; Choi, Kyung/B-1512-2008 OI Choi, Kyung/0000-0003-2384-6220 FU University of Iowa; Automotive Research Center (ARC); U.S. Army Tank Automotive Research, Development and Engineering Center (TARDEC) [W56HZV-04-2-0001]; Technology Innovation Program - Ministry of Trade, Industry & Energy (MI, Korea) [10048305] FX Research was supported by the University of Iowa 2013 Ice Commercialization GAP Fund. This research was also partially supported by the Automotive Research Center (ARC) in accordance with Cooperative Agreement No. W56HZV-04-2-0001 U.S. Army Tank Automotive Research, Development and Engineering Center (TARDEC); and the Technology Innovation Program (No. 10048305, Launching Plug-in Digital Analysis Framework for Modular System Design) funded by the Ministry of Trade, Industry & Energy (MI, Korea). These supports are greatly appreciated. NR 28 TC 2 Z9 2 U1 0 U2 0 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 1050-0472 J9 J MECH DESIGN JI J. Mech. Des. PD JAN PY 2016 VL 138 IS 1 AR 011405 DI 10.1115/1.4031829 PG 10 WC Engineering, Mechanical SC Engineering GA CY8CW UT WOS:000366637200007 ER PT J AU Allison, PG Seiter, JM Diaz, A Lindsay, JH Moser, RD Tappero, RV Kennedy, AJ AF Allison, Paul G. Seiter, Jennifer M. Diaz, Alfredo Lindsay, James H. Moser, Robert D. Tappero, Ryan V. Kennedy, Alan J. TI Gastropod (Otala lactea) shell nanomechanical and structural characterization as a biomonitoring tool for dermal and dietary exposure to a model metal SO JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS LA English DT Article DE Biomonitoring; Gastropod; Nanoindentation; Synchrotron; Heavy Metal; X-ray ID HEAVY-METALS; MECHANICAL-PROPERTIES; MOLLUSCAN SHELL; BIOACCUMULATION; TUNGSTEN; POLLUTION; SEA; BIOAVAILABILITY; ACCUMULATION; PERFORMANCE AB Metallic tungsten (W) was initially assumed to be environmentally benign and a green alternative to lead. However, subsequent investigations showed that fishing weights and munitions containing elemental W can fragment and oxidize into complex monomeric and polymeric tungstate (WO4) species in the environment; this led to increased solubility and mobility in soils and increased bioaccumulation potential in plant and animal tissues. Here we expand on the results of our previous research, which examined tungsten toxicity, bioaccumulation, and compartmentalization into organisms, and present in this research that the bioaccumulation of W was related to greater than 50% reduction in the mechanical properties of the snail (Otala lactea), based on depth-sensing nanoindentation. Synchrotron-based X-ray fluorescence maps and X-ray diffraction measurements confirm the integration of Win newly formed layers of the shell matrix with the observed changes in shell biomechanical properties, mineralogical composition, and crystal orientation. With further development, this technology could be employed as a biomonitoring tool for historic metals contamination since unlike the more heavily studied bioaccumulation into soft tissue, shell tissue does not actively eliminate contaminants. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Allison, Paul G.] Univ Alabama, Dept Mech Engn, Tuscaloosa, AL 35406 USA. [Seiter, Jennifer M.; Lindsay, James H.; Kennedy, Alan J.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Diaz, Alfredo] Univ Puerto Rico, Dept Mech Engn, Mayaguez, PR 00681 USA. [Moser, Robert D.] US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. [Tappero, Ryan V.] Brookhaven Natl Lab, Natl Synchrotron Light Source, Upton, NY 11973 USA. RP Allison, PG (reprint author), Univ Alabama, Dept Mech Engn, Box 870276, Tuscaloosa, AL 35406 USA. EM pallison@eng.ua.edu FU Army Environmental Quality Technology Basic Research Program [EQI-10-42]; U.S. Department of Energy (DOE) - Geosciences [DE-FG02-92ER14244]; DOE, Office of Science, Office of Basic Energy Sciences [DE-AC02-98CH10886] FX This work was funded by the Army Environmental Quality Technology Basic Research Program (EQI-10-42) (US Army Engineer Research and Development Center, Dr. Elizabeth Ferguson, Technical Director). Portions of this work were performed at Beamline X27A, National Synchrotron Light Source (NSLS), Brookhaven National Laboratory. X27A is supported in part by the U.S. Department of Energy (DOE) - Geosciences (DE-FG02-92ER14244 to the University of Chicago - CARS). Use of the NSLS was supported by the DOE, Office of Science, Office of Basic Energy Sciences, under Contract no. DE-AC02-98CH10886. Permission to publish granted by Director of the Geotechnical and Structures Laboratory. NR 49 TC 0 Z9 0 U1 5 U2 15 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1751-6161 EI 1878-0180 J9 J MECH BEHAV BIOMED JI J. Mech. Behav. Biomed. Mater. PD JAN PY 2016 VL 53 BP 142 EP 150 DI 10.1016/j.jmbbm.2015.08.016 PG 9 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA CY2GJ UT WOS:000366226500013 PM 26318574 ER PT J AU Julian, DW Hickey, JT Fields, WL Ostadrahimi, L Maher, KM Barker, TG Hatfield, CL Lutz, K Marks, CO Sandoval-Solis, S Lund, JR AF Julian, David W. Hickey, John T. Fields, Woodrow L. Ostadrahimi, Leila Maher, Katherine M. Barker, Townsend G. Hatfield, Christopher L. Lutz, Kim Marks, Christian O. Sandoval-Solis, Samuel Lund, Jay R. TI Decision Support System for Water and Environmental Resources in the Connecticut River Basin SO JOURNAL OF WATER RESOURCES PLANNING AND MANAGEMENT LA English DT Article DE Natural flow regime; Environmental flows; Reservoir management; Floodplain forest inundation; Hydrologic alteration; Hydropower; Flood control ID HYDROLOGIC ALTERATION; FLOODPLAIN FOREST; FLOWS; MODEL; MANAGEMENT; RESERVOIR; HABITAT; STREAM; RESTORATION; COMMUNITIES AB This paper describes the development and application of a reservoir management decision support system for evaluating flood-plain benefits and socioeconomic trade-offs of reservoir management alternatives in the Connecticut River watershed. The decision support system is composed of a reservoir system simulation model, an ecological model, and two river hydraulics models. The reservoir model simulated current operations at 73 reservoirs and flows at locations of interest in the Connecticut River watershed. Regulated flows from the reservoir model were compared with unregulated flows, both statistically and spatially, for a suite of environmental flow metrics based on inundation patterns related to floodplain vegetation communities. Analyses demonstrate use of the decision support system and show how its use illuminates (1) trends in existing hydrologic alteration for the Connecticut River mainstem and one of its tributaries, the Farmington River, and (2) management scenarios that might have ecological benefits for floodplain plant communities. The decision support system was used to test two management scenarios to assess potential floodplain benefits and associated trade-offs in hydropower generation and flood risk. The process described shows the usefulness of large-scale reservoir management decision support systems that incorporate environmental considerations in assisting with watershed planning and environmental flow implementation. (C) 2015 American Society of Civil Engineers. C1 [Julian, David W.] Univ Calif Davis, Dept Civil & Environm Engn, Davis, CA 95616 USA. [Hickey, John T.; Fields, Woodrow L.; Ostadrahimi, Leila] US Army Corps Engineers, Hydrol Engn Ctr, Davis, CA 95616 USA. [Maher, Katherine M.] GEI Consultants Inc, Rancho Cordova, CA 95670 USA. [Barker, Townsend G.] US Army Corps Engineers, New England Dist, Water Management Sect, Concord, MA 01742 USA. [Hatfield, Christopher L.] US Army Corps Engineers, New England Dist, Planning Branch, Concord, MA 01742 USA. [Lutz, Kim] Nature Conservancy, Northampton, MA 01060 USA. [Marks, Christian O.] Nature Conservancy, Connecticut River Program, Northampton, MA 01060 USA. [Sandoval-Solis, Samuel] Univ Calif Davis, Dept Land Air & Water Resources, Davis, CA 95616 USA. [Lund, Jay R.] Univ Calif Davis, Civil & Environm Engn, Davis, CA 95616 USA. RP Julian, DW (reprint author), CH2M Hill,2485 Natomas Pk Dr, Sacramento, CA 95833 USA. EM david.julian@ch2m.com; John.Hickey@usace.army.mil; Woodrow.L.Fields@usace.army.mil; Leila.ostadrahimi@usace.army.mil; kmaher@geiconsultants.com; Townsend.g.barker@usace.army.mil; christopher.l.hatfield@usace.army.mil; klutz@tnc.org; cmarks@tnc.org; samsandoval@ucdavis.edu; jrlund@ucdavis.edu NR 74 TC 0 Z9 0 U1 7 U2 26 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9496 EI 1943-5452 J9 J WATER RES PLAN MAN JI J. Water Resour. Plan. Manage.-ASCE PD JAN PY 2016 VL 142 IS 1 AR 04015038 DI 10.1061/(ASCE)WR.1943-5452.0000538 PG 16 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA CY9TW UT WOS:000366750200001 ER PT J AU Burgert, JM Johnson, AD Garcia-Blanco, J Froehle, J Morris, T Althuisius, B Richards, J Castano, C AF Burgert, James M. Johnson, Arthur D. Garcia-Blanco, Jose Froehle, Jacob Morris, Todd Althuisius, Ben Richards, Jennifer Castano, Christopher TI The effects of proximal and distal routes of intraosseous epinephrine administration on short-term resuscitative outcome measures in an adult swine model of ventricular fibrillation: a randomized controlled study SO AMERICAN JOURNAL OF EMERGENCY MEDICINE LA English DT Article ID CARDIOPULMONARY-RESUSCITATION; CARDIAC-ARREST; VASCULAR ACCESS; PHARMACOKINETICS; VASOPRESSIN; INFUSIONS; PIGS AB Introduction: It is unknown if the anatomical distance of intraosseous (IO) epinephrine injection from the heart affects resuscitative outcome. The purpose of this study was to explore the relationships between the anatomical distance of IO epinephrine injection and measures of resuscitative outcome in an adult swine model of ventricular fibrillation (VF). Methods: Thirty-two Yorkshire-cross swine (60-80 kg) were randomly assigned to four groups: humeral IO (HIO), tibial IO (TIO), IV with defibrillation and epinephrine, and IV control: with defibrillation but no epinephrine. Ventricular fibrillation was induced. Swine remained in VF for 4 minutes prior to mechanical chest compressions. After 6 minutes in VF, swine were defibrillated and epinephrine (0.01 mg/kg) administered by group assignment. Defibrillation was repeated every 2 minutes. Epinephrine was repeated every 4 minutes. Interventions continued until return of spontaneous circulation (ROSC) or 26 post-arrest minutes elapsed. Swine achieving ROSC were observed for 30 minutes post-ROSC. Results: There were no significant differences between the HIO, TIO, and IV groups relative to the occurrence of ROSC (P > .05 in all cases), 30-minute post-ROSC survival (P > .05 in all cases), and time to ROSC (P =.43). There were significant differences between the HIO, TIO, and IV groups compared to the control group relative to the occurrence of ROSC (P = .02, .01, and .007 respectively), and 30 minute post-ROSC survival (P =.05, .03, and .007, respectively). Conclusion: The anatomical distance of IO epinephrine injection from the heart did not affect short-term measures of resuscitative outcome in an adult swine model of VF including the occurrence of ROSC, 30 minute post-ROSC survival, and time to ROSC. Rapidly administered epinephrine, irrespective of route of administration, increased the chance ROSC and survival to 30 minutes post-ROSC would occur in this study. Published by Elsevier Inc. C1 [Burgert, James M.; Johnson, Arthur D.; Froehle, Jacob; Morris, Todd; Althuisius, Ben; Richards, Jennifer; Castano, Christopher] Northeastern Univ, US Army Med Dept Ctr & Sch, Houston, TX 78234 USA. [Burgert, James M.; Johnson, Arthur D.; Garcia-Blanco, Jose] Geneva Fdn, Tacoma, WA 98402 USA. RP Burgert, JM (reprint author), Northeastern Univ, US Army Med Dept & Sch, US Army Grad Program Anesthesia Nursing, 3490 Forage Rd,Suite 112, Ft Sam Houston, TX 78234 USA. EM james.burgert@alumni.bcm.edu OI Burgert, James/0000-0001-8346-6196 FU American Association of Nurse Anesthetists Foundation [2014-F-13] FX This work was funded by a postdoctoral fellowship (2014-F-13) granted by the American Association of Nurse Anesthetists Foundation. The funding source had no role in the design of the study; the collection, analysis, and interpretation of the data; writing the report; and the decision to submit the article for publication. NR 26 TC 1 Z9 1 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0735-6757 EI 1532-8171 J9 AM J EMERG MED JI Am. J. Emerg. Med. PD JAN PY 2016 VL 34 IS 1 BP 49 EP 53 DI 10.1016/j.ajem.2015.09.007 PG 5 WC Emergency Medicine SC Emergency Medicine GA CY1IH UT WOS:000366159400010 PM 26462903 ER PT J AU Hogan, JD Farbaniec, L Sano, T Shaeffer, M Ramesh, KT AF Hogan, James David Farbaniec, Lukasz Sano, Tomoko Shaeffer, Matthew Ramesh, K. T. TI The effects of defects on the uniaxial compressive strength and failure of an advanced ceramic SO ACTA MATERIALIA LA English DT Article DE Compressive strength; Defect statistics; Brittle failure; Experimental mechanics; Microstructure design ID PRESSED SILICON-CARBIDE; BORON-CARBIDE; BRITTLE MATERIALS; DYNAMIC STRENGTH; ALUMINUM NITRIDE; BEHAVIOR; FRACTURE; CONFINEMENT; MODEL AB This study investigates the effects of the processing-induced defect population on the dynamic compressive strength and failure of a hot-pressed boron carbide. Quantitative microscopic analysis was used to determine the distributions of three types of processing-induced inhomogeneities: aluminum nitride, small graphitic particles and pores, and larger graphitic disks. Scanning electron microscopy of fracture surfaces identifies the graphitic disks as fracture initiation sites. The size, orientation and number density of the graphitic disks are then quantified using image processing techniques. We use these defect statistics, in conjunction with recent scaling models, to explore our experimentally measured dynamic compressive strength results. (C) 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Hogan, James David] Univ Alberta, Dept Mech Engn, Edmonton, AB T6G 2R3, Canada. [Hogan, James David; Farbaniec, Lukasz; Shaeffer, Matthew; Ramesh, K. T.] Johns Hopkins Univ, Hopkins Extreme Mat Inst, Baltimore, MD 21218 USA. [Sano, Tomoko] Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Ramesh, K. T.] Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. RP Hogan, JD (reprint author), Univ Alberta, Dept Mech Engn, Edmonton, AB T6G 2R3, Canada. EM jdhogan@ualberta.ca OI Hogan, James/0000-0002-9212-9252 FU Army Research Laboratory [W911NF-12-2-0022] FX This research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-12-2-0022. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. Kanak Kuwelkar from Rutgers and Matthew Bratcher from Army Research Laboratories are acknowledged for discussions of the microstructure, Will Wagers, Joe Hajj and Nicole Cade-Ferreira from the Johns Hopkins University are thanked for helping run the experiments. NR 31 TC 6 Z9 6 U1 3 U2 28 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6454 EI 1873-2453 J9 ACTA MATER JI Acta Mater. PD JAN 1 PY 2016 VL 102 BP 263 EP 272 DI 10.1016/j.actamat.2015.09.028 PG 10 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA CX0ED UT WOS:000365368800027 ER PT J AU Shrestha, R Simsiriwong, J Shamsaei, N Moser, RD AF Shrestha, Rakish Simsiriwong, Jutima Shamsaei, Nima Moser, Robert D. TI Cyclic deformation and fatigue behavior of polyether ether ketone (PEEK) SO INTERNATIONAL JOURNAL OF FATIGUE LA English DT Article DE Thermoplastics; Fatigue; Cyclic behavior; Frequency effect; Energy approach ID STRAIN RATES; EPOXY-RESIN; WIDE-RANGE; STRESS; POLYMERS; TEMPERATURES AB In this study, the fatigue behavior of a semi-crystalline thermoplastic polyether ether ketone (PEEK) is investigated. A series of tests at ambient temperature, including uniaxial monotonic (tension and compression) at different strain rates and uniaxial fully-reversed strain-controlled cyclic tests at strain amplitudes ranging from 0.02 mm/mm to 0.04 mm/mm at various frequencies, were conducted. The frequency influence on the strain-controlled fatigue lives of unfilled PEEK specimens was found to be highly dependent on the strain level. A minimal frequency effect was observed at a lower strain amplitude of 0.02 mm/mm, whereas increasing the test frequency at higher strain amplitudes resulted in longer fatigue lives. Additionally, load-controlled cyclic tests that utilized applied loads corresponding to stress responses obtained from the strain-controlled fatigue tests were performed. The cyclic behavior under the two control modes were compared and discussed. Three types of fatigue models, including a strain-based (Coffin-Manson) model, a strain-stress-based (Smith-Watson-Topper) model, and an energy-based model, were employed to correlate the data in this study. Among the three fatigue models, the energy approach was found to better correlate the PEEK experimental data at various frequencies. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Shrestha, Rakish; Shamsaei, Nima] Mississippi State Univ, Dept Mech Engn, Mississippi State, MS 39762 USA. [Simsiriwong, Jutima; Shamsaei, Nima] Mississippi State Univ, CAVS, Mississippi State, MS 39762 USA. [Moser, Robert D.] US Army, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Shamsaei, N (reprint author), Mississippi State Univ, Dept Mech Engn, Box 9552, Mississippi State, MS 39762 USA. EM shamsaei@me.msstate.edu FU U.S. Government [W15QKN-13-9-0001] FX This effort was sponsored by the U.S. Government under Other Transaction no. W15QKN-13-9-0001 between the Consortium for Energy, Environment and Demilitarization, and the Government. The U.S. Government is authorized to reproduce and distribute reprints for Governmental purposes notwithstanding any copyright notation thereon. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of the U.S. Government. NR 34 TC 6 Z9 6 U1 4 U2 19 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0142-1123 EI 1879-3452 J9 INT J FATIGUE JI Int. J. Fatigue PD JAN PY 2016 VL 82 BP 411 EP 427 DI 10.1016/j.ijfatigue.2015.08.022 PN 3 PG 17 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA CX0DC UT WOS:000365366100006 ER PT J AU Shen, J Kondoh, K Jones, TL Mathaudhu, SN Kecskes, LJ Wei, Q AF Shen, J. Kondoh, K. Jones, T. L. Mathaudhu, S. N. Kecskes, L. J. Wei, Q. TI Effect of strain rate on the mechanical properties of magnesium alloy AMX602 SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Magnesium alloy; Strengthening mechanisms; Adiabatic shear band; Strain rate effect ID METAL-MATRIX COMPOSITES; SOLIDIFICATION POWDER-METALLURGY; HALL-PETCH RELATION; ROOM-TEMPERATURE; MG ALLOY; PLASTIC-DEFORMATION; TEXTURE EVOLUTION; GRAIN-REFINEMENT; PURE MAGNESIUM; NONBASAL SLIP AB In the present work, the effect of strain rate on the mechanical properties, particularly the plastic deformation behavior of a magnesium alloy, AMX602 (Mg-6%Al-0.5%Mn-2%Ca; all wt%), fabricated by powder metallurgy, has been investigated under both quasi-static (strain rate 1 x 10(-3) s(-1)) and dynamic (strain rate 4 x 10(3) s(-1)) compressive loading. The alloyed powder was extruded at three different temperatures. The microstructure of the alloy was examined by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). It was found that AMX602 exhibits an impressive mechanical behavior but with a slight anisotropy along different directions in both strength and compressive ductility (or malleability). The strength was found to be nearly independent of the extrusion temperature, particularly, under dynamic loading. Nanoindentation strain rate jump test reveals a strain rate sensitivity of similar to 0.018 to similar to 0.015, depending on the extrusion temperature. Sub-micrometer-scale particles of the intermetallic compound Al2Ca were found with sizes ranging from similar to 100 nm to similar to 1.0 mu m. These intermetallic particles are believed to have precipitated out during the extrusion process. They contribute to the formation of the ultrafine equiaxed grains which, in turn, help to improve the strength of the alloy by acting as barriers to dislocation motion. Adiabatic shear bands (ASBs) were observed in the dynamically loaded samples, the propagation of which eventually leads to final fracture of the specimens. (C) 2015 Elsevier B.V. All rights reserved. C1 [Shen, J.; Wei, Q.] Univ N Carolina, Dept Mech Engn, Charlotte, NC 28223 USA. [Kondoh, K.] Osaka Univ, Joining & Welding Res Inst, Osaka 5670047, Japan. [Jones, T. L.; Kecskes, L. J.] US Army Res Lab, WMRD, Aberdeen Proving Ground, MD 21005 USA. [Mathaudhu, S. N.] Univ Calif Riverside, Dept Mech Engn, Riverside, CA 92521 USA. RP Wei, Q (reprint author), Univ N Carolina, Dept Mech Engn, Charlotte, NC 28223 USA. EM qwei@uncc.edu RI Wei, Qiuming/B-7579-2008; Shen, Jianghua/C-2586-2013 OI Shen, Jianghua/0000-0003-1017-0698 FU US Army Research Laboratory [W911QX-08-0073, W911NF-14-2-0061]; China Scholarship Council, National Natural Science Foundation of China [10932008]; 111 Project [B07050] FX This work is supported by US Army Research Laboratory under Contract nos. W911QX-08-0073 and W911NF-14-2-0061. J. H. Shen would like to acknowledge the financial support from China Scholarship Council, National Natural Science Foundation of China (No. 10932008) and the 111 Project (No. B07050). NR 73 TC 3 Z9 3 U1 14 U2 49 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 EI 1873-4936 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD JAN 1 PY 2016 VL 649 BP 338 EP 348 DI 10.1016/j.msea.2015.10.022 PG 11 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA CW2BP UT WOS:000364796400040 ER PT J AU Williams, D AF Williams, Daniel TI CRACKING THE CODE ON THE "HIDDEN CURRICULUM" IN THE MEDICAL EDUCATION PIPELINE AND ITS CONTRIBUTION TO ATTRITION SO Journal of Unschooling and Alternative Learning LA English DT Article DE Premed syndrome; medical school attrition; physician satisfaction; workforce; malignant residency programs ID STUDENTS PERCEPTIONS; SELF-ASSESSMENT; SCHOOL; PHYSICIANS; SATISFACTION; PERFORMANCE; RESIDENTS; BURNOUT; CAREER; PROFESSIONALISM AB Physicians withstand one of the longest and most complicated educational processes in existence. There are a multitude of personal and professional developmental steps along the way that contribute to physician burnout and career dissatisfaction. This article is the first attempt of its kind to conceptualize these various influences into a series of five phases that each physician-in-training experiences, beginning before medical school even starts. The five phases are: 1. The Pre-Med Syndrome, 2. Adaptation, 3. Assimilation, 4. The Let Down, and 5. Reemerging Priorities. Three of the five phases described here can negatively influence the physician's psychological well-being, while two of the phases are quite positive and encouraging. The phases don't necessarily have to occur in sequential order and may be repeated cyclically within each of the formal academic steps (i.e., undergraduate, basic science years of medical school, and the clinical science years). Hopefully, this perspective paper will contribute further to the active discussion of how to make medical education more effective and palatable. C1 [Williams, Daniel] East Texas Med Ctr Behav Hlth Ctr, Tyler, TX USA. RP Williams, D (reprint author), US Army Natl Guard, Montgomery, AL 36109 USA. EM drdanielwilliams@gmail.com NR 60 TC 0 Z9 0 U1 4 U2 12 PU NIPISSING UNIV PI NORTH BAY PA 100 COLLEGE DR, PO BOX 5002, NORTH BAY, ON P1B 8L7, CANADA SN 1916-8128 J9 J UNSCH ALTERN LEARN JI J. Unsch. Altern. Learn. PY 2016 VL 10 IS 19 BP 82 EP 99 PG 18 WC Education & Educational Research SC Education & Educational Research GA CU8HV UT WOS:000363783500004 ER PT J AU Brown, TN O'Donovan, M Hasselquist, L Corner, B Schiffman, JM AF Brown, T. N. O'Donovan, M. Hasselquist, L. Corner, B. Schiffman, J. M. TI Lower limb flexion posture relates to energy absorption during drop landings with soldier-relevant body borne loads SO APPLIED ERGONOMICS LA English DT Article DE Kinematics; Kinetics; Energy absorption; Impact force ID LOWER-EXTREMITY BIOMECHANICS; CRUCIATE LIGAMENT INJURY; JOINT COORDINATE SYSTEM; GROUND REACTION FORCES; SINGLE-LEG LANDINGS; IMPACT FORCES; 3 HEIGHTS; KINEMATICS; KINETICS; EPIDEMIOLOGY AB military personnel performed 30-cm drop landings to quantify how body borne load (light, similar to 6 kg, medium, similar to 20 kg, and heavy, similar to 40 kg) impacts lower limb kinematics and knee joint energy absorption during landing, and determine whether greater lower limb flexion increases energy absorption while landing with load. Participants decreased peak hip (P = 0.002), and knee flexion (P = 0.007) posture, but did not increase hip (P = 0.796), knee (P = 0.427) or ankle (P = 0.161) energy absorption, despite exhibiting greater peak hip (P = 0.003) and knee (P = 0.001) flexion, and ankle (P = 0.003) dorsiflexion angular impulse when landing with additional load. Yet, when landing with the light and medium loads, greater hip (R-2 = 0.500, P = 0.003 and R-2 = 0.314, P = 0.030) and knee (R-2 = 0.431, P = 0.008 and R-2 = 0.342, P = 0.022) flexion posture predicted larger knee joint energy absorption. Thus, military training that promotes hip and knee flexion, and subsequently greater energy absorption during landing, may potentially reduce risk of musculoskeletal injury and optimize soldier performance. Published by Elsevier Ltd. C1 [Brown, T. N.] ORISE, Belcamp, MD USA. [Brown, T. N.; O'Donovan, M.; Hasselquist, L.; Corner, B.; Schiffman, J. M.] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA USA. [Schiffman, J. M.] Liberty Mutual Res Inst Safety, Hopkinton, MA USA. RP Brown, TN (reprint author), Natick Soldier RD & E Ctr, Dept Army, 15 Kansas St, Natick, MA 01760 USA. EM tyler.n.brown4.civ@mail.mil FU Department of the Army, Office of the Assistant Secretary of the Army - Acquisition Logistics and Technology FX This work was supported by an FY 12 Competitive In-house Laboratory Independent Research (ILIR) Award program from the Department of the Army, Office of the Assistant Secretary of the Army - Acquisition Logistics and Technology. The authors thank Ms. Marina Carboni and Mr. Albert Adams for their assistance with this study. NR 41 TC 2 Z9 2 U1 4 U2 27 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0003-6870 EI 1872-9126 J9 APPL ERGON JI Appl. Ergon. PD JAN PY 2016 VL 52 BP 54 EP 61 DI 10.1016/j.apergo.2015.06.004 PG 8 WC Engineering, Industrial; Ergonomics; Psychology, Applied SC Engineering; Psychology GA CS5QQ UT WOS:000362133400007 PM 26360194 ER PT J AU Marayati, BF Schal, C Ponnusamy, L Apperson, CS Rowland, TE Wasserberg, G AF Marayati, Bahjat Fadi Schal, Coby Ponnusamy, Loganathan Apperson, Charles S. Rowland, Tobin E. Wasserberg, Gideon TI Attraction and oviposition preferences of Phlebotomus papatasi (Diptera: Psychodidae), vector of Old-World cutaneous leishmaniasis, to larval rearing media SO PARASITES & VECTORS LA English DT Article DE Leishmaniasis; Oviposition behavior; Sand flies; Semiochemicals; Bioassay; Olfactometer ID SANDFLY LUTZOMYIA-LONGIPALPIS; CHEMICAL ECOLOGY; CONSPECIFIC EGGS; BREEDING SITES; FLIES; IDENTIFICATION; PHEROMONE; BIOLOGY AB Background: As part of a project aimed at developing oviposition attractants for the control and surveillance of Phlebotomus papatasi (a vector of Old-World cutaneous leishmaniasis), we tested the hypothesis that gravid sand flies are attracted to chemical cues emanating from the growth medium of conspecific larvae - predominantly larvae-conditioned host feces that represents a suitable oviposition site. We report the results of a systematic assessment of media from various developmental stages of the sand fly using oviposition and olfactometer behavioral assays. Methods: We conducted multiple-choice oviposition assays in 500 mL Nalgene jars. Six treatments were placed on separate filter paper discs at the bottom of the jar: 2nd/3rd larval instar medium, 4th larval instar/pupae medium, frass from expired colonies, larval food (aged rabbit chow and rabbit feces mix), rabbit feces, and a solvent (water) control. Fifty gravid females were introduced into each jar. Cumulative number of eggs laid on each filter paper per jar was counted at different time intervals from digital images. Attraction of gravid sand flies to these six treatments was assayed with a 3-chamber linear olfactometer. Twenty gravid females were transferred to the middle chamber of the olfactometer and their distribution in treatment and control chambers was recorded after 3 h. Results: Almost no eggs were oviposited during the first 72 h following a blood-meal. Cumulative egg deposition increased drastically in the next 24 h (hours 73-96), with a slight non-significant increasing trend thereafter. Comparing mean cumulative egg deposition among the six treatments, we found that significantly more eggs were oviposited on 2nd/3rd larval rearing medium followed by 4th instar/pupae rearing medium. Oviposition preference did not vary over time. The olfactometer results were consistent with the oviposition assays, with 2nd/3rd larval rearing medium being the most attractive, followed by 4th instar/pupae rearing medium. Conclusion: The key finding of this study is that gravid, laboratory reared, Ph. papatasi sand flies are significantly more attracted to rearing medium of the most biologically active larval stages (2nd/3rd instar and 4th instar/pupae). This finding indicates that sand fly-digested host food and feces is attractive to gravid females and suggests that the larvae and larval gut microbiome may be involved in conditioning the oviposition substrate and possibly the production of oviposition attractants and stimulants. C1 [Marayati, Bahjat Fadi; Wasserberg, Gideon] Univ N Carolina, Dept Biol, Greensboro, NC 27402 USA. [Schal, Coby; Ponnusamy, Loganathan; Apperson, Charles S.] N Carolina State Univ, Dept Entomol, Raleigh, NC 27695 USA. [Rowland, Tobin E.] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD 20910 USA. RP Wasserberg, G (reprint author), Univ N Carolina, Dept Biol, 235 Eberhart Bldg, Greensboro, NC 27402 USA. EM g_wasser@uncg.edu RI Schal, Coby/A-8717-2010 OI Schal, Coby/0000-0001-7195-6358 FU North Carolina Biotechnology Center Multidisciplinary Research Grant (MRG) [1104]; NIAID FX We thank Edgar D. Rowton for helpful advice and discussions. This research was supported by the North Carolina Biotechnology Center Multidisciplinary Research Grant (MRG) number 1104. We thank NIAID funded BEI Resources Repository for providing resources for obtaining additional sand fly pots. NR 42 TC 0 Z9 0 U1 0 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1756-3305 J9 PARASITE VECTOR JI Parasites Vectors PD DEC 30 PY 2015 VL 8 AR 663 DI 10.1186/s13071-015-1261-z PG 9 WC Parasitology SC Parasitology GA CZ8BU UT WOS:000367325800002 PM 26714743 ER PT J AU Wilkerson, RC Linton, YM AF Wilkerson, Richard C. Linton, Yvonne-Marie TI Elevation of Pseudoskusea, Rusticoidus and Protomacleaya to valid subgenera in the mosquito genus Aedes based on taxon naming criteria recently applied to other members of the Tribe Aedini (Diptera: Culicidae) SO PARASITES & VECTORS LA English DT Article DE Tribe Aedini; Aedes; Subgenera; Elevation ID LIFE STAGES; MORPHOLOGICAL DATA; CLASSIFICATION; PHYLOGENY; OCHLEROTATUS AB Background: Pseudoskusea, Rusticoidus and Protomacleaya were well-recognized, morphologically distinct subgenera within the genus Aedes prior to a series of taxonomic changes over the past 15 years by Reinert, Harbach and Kitching, when they were recognized as subgenera of the genus Ochlerotatus. In our recent effort to stabilize the Tribe Aedini, we synonymized these subgenera and associated species back into the genus Aedes, but incorrectly assigned them as putative informal groups, instead of reinstating them to subgenera. Conclusion: Here we formally elevate three traditionally recognized subgenera (Pseudoskusea, Rusticoidus and Protomacleaya) within the genus Aedes. C1 [Wilkerson, Richard C.; Linton, Yvonne-Marie] Smithsonian Inst, Natl Museum Nat Hist, Dept Entomol, Washington, DC 20560 USA. [Linton, Yvonne-Marie] Smithsonian Inst, Walter Reed Biosystemat Unit, Museum Support Ctr, Suitland, MD USA. [Linton, Yvonne-Marie] Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD USA. [Linton, Yvonne-Marie] Uniformed Serv Univ Hlth Sci, Fac Preventat Med & Biometr, Bethesda, MD 20814 USA. RP Wilkerson, RC (reprint author), Smithsonian Inst, Natl Museum Nat Hist, Dept Entomol, Washington, DC 20560 USA. EM wilkersonr@si.edu FU National Research Council (NRC) FX We thank Bruce Harrison for careful review of the manuscript and his many helpful comments. This research was performed under a Memorandum of Understanding between the Walter Reed Army Institute of Research and the Smithsonian Institution, with institutional support provided by both organizations. This manuscript was prepared whilst YML held a National Research Council (NRC) Research Associateship Award at the Walter Reed Army Institute of Research. The material to be published reflects the views of the authors and should not be construed to represent those of the U.S. Department of the Army or the U.S. Department of Defense. NR 29 TC 1 Z9 1 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1756-3305 J9 PARASITE VECTOR JI Parasites Vectors PD DEC 30 PY 2015 VL 8 AR 668 DI 10.1186/s13071-015-1247-x PG 4 WC Parasitology SC Parasitology GA CZ8BY UT WOS:000367326200002 PM 26714624 ER PT J AU Gordon, SM Lawhern, V Passaro, AD McDowell, K AF Gordon, S. M. Lawhern, V. Passaro, A. D. McDowell, K. TI Informed decomposition of electroencephalographic data SO JOURNAL OF NEUROSCIENCE METHODS LA English DT Article DE Independent components analysis; EEG; Independent subspace analysis; Informed source separation ID INDEPENDENT COMPONENT ANALYSIS; BLIND SOURCE SEPARATION; MUSCLE ARTIFACT REMOVAL; CONSTRAINED ICA; SLEEP EEG; INFORMATION; ALGORITHMS; IMPROVE; SIGNALS; TOOL AB Background: Blind source separation techniques have become the de facto standard for decomposing electroencephalographic (EEG) data. These methods are poorly suited for incorporating prior information into the decomposition process. While alternative techniques to this problem, such as the use of constrained optimization techniques, have been proposed, these alternative techniques tend to only minimally satisfy the prior constraints. In addition, the experimenter must preset a number of parameters describing both this minimal limit as well as the size of the target subspaces. New method: We propose an informed decomposition approach that builds upon the constrained optimization approaches for independent components analysis to better model and separate distinct subspaces within EEG data. We use a likelihood function to adaptively determine the optimal model size for each target subspace. Results: Using our method we are able to produce ordered independent subspaces that exhibit less residual mixing than those obtained with other methods. The results show an improvement in modeling specific features of the EEG space, while also showing a simultaneous reduction in the number of components needed for each model. Comparison with existing method(s): We first compare our approach to common methods in the field of EEG decomposition, such as Infomax, FastICA, PCA, JADE, and SOBI for the task of modeling and removing both EOG and EMG artifacts. We then demonstrate the utility of our approach for the more complex problem of modeling neural activity. Conclusions: By working in a one-size-fits-all fashion current EEG decomposition methods do not adapt to the specifics of each data set and are not well designed to incorporate additional information about the decomposition problem. However, by adding specific information about the problem to the decomposition task, we improve the identification and separation of distinct subspaces within the original data and show better preservation of the remaining data. (C) 2015 The Authors. Published by Elsevier B.V. C1 [Gordon, S. M.; Passaro, A. D.] DCS Corp, Alexandria, VA 22310 USA. [Lawhern, V.; McDowell, K.] US Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Gordon, SM (reprint author), DCS Corp, Alexandria, VA 22310 USA. EM sgordon@dcscorp.com FU Army Research Laboratory [W911NF-10-2-0022] FX The authors would like to thank Dr. Kelvin Oie of the Army Research Laboratory and Dr. Jason Metcalfe of DCS Corporation for helpful discussions and directions with respect to the experimental design. The authors would also like to thank Dr. Piotr Franaszczuk of the Army Research Laboratory for his overall guidance and instruction. This research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-10-2-0022. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 61 TC 3 Z9 3 U1 2 U2 15 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-0270 EI 1872-678X J9 J NEUROSCI METH JI J. Neurosci. Methods PD DEC 30 PY 2015 VL 256 BP 41 EP 55 DI 10.1016/j.jneumeth.2015.08.019 PG 15 WC Biochemical Research Methods; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA CY7VW UT WOS:000366618400005 PM 26306657 ER PT J AU Wallqvist, A Memisevic, V Zavaljevski, N Pieper, R Rajagopala, SV Kwon, K Yu, CG Hoover, TA Reifman, J AF Wallqvist, Anders Memisevic, Vesna Zavaljevski, Nela Pieper, Rembert Rajagopala, Seesandra V. Kwon, Keehwan Yu, Chenggang Hoover, Timothy A. Reifman, Jaques TI Using host-pathogen protein interactions to identify and characterize Francisella tularensis virulence factors SO BMC GENOMICS LA English DT Article DE Host-pathogen interactions; Protein-protein interactions; Francisella tularensis; Intracellular pathogen; Virulence factors ID INTRACELLULAR SURVIVAL; INTERACTION NETWORK; OXIDATIVE STRESS; DATABASE; GROWTH; IDENTIFICATION; MACROPHAGES; SECRETION; GENES; DETERMINANTS AB Background: Francisella tularensis is a select bio-threat agent and one of the most virulent intracellular pathogens known, requiring just a few organisms to establish an infection. Although several virulence factors are known, we lack an understanding of virulence factors that act through host-pathogen protein interactions to promote infection. To address these issues in the highly infectious F. tularensis subsp. tularensis Schu S4 strain, we deployed a combined in silico, in vitro, and in vivo analysis to identify virulence factors and their interactions with host proteins to characterize bacterial infection mechanisms. Results: We initially used comparative genomics and literature to identify and select a set of 49 putative and known virulence factors for analysis. Each protein was then subjected to proteome-scale yeast two-hybrid (Y2H) screens with human and murine cDNA libraries to identify potential host-pathogen protein-protein interactions. Based on the bacterial protein interaction profile with both hosts, we selected seven novel putative virulence factors for mutant construction and animal validation experiments. We were able to create five transposon insertion mutants and used them in an intranasal BALB/c mouse challenge model to establish 50 % lethal dose estimates. Three of these, Delta FTT0482c, Delta FTT1538c, and Delta FTT1597, showed attenuation in lethality and can thus be considered novel F. tularensis virulence factors. The analysis of the accompanying Y2H data identified intracellular protein trafficking between the early endosome to the late endosome as an important component in virulence attenuation for these virulence factors. Furthermore, we also used the Y2H data to investigate host protein binding of two known virulence factors, showing that direct protein binding was a component in the modulation of the inflammatory response via activation of mitogen-activated protein kinases and in the oxidative stress response. Conclusions: Direct interactions with specific host proteins and the ability to influence interactions among host proteins are important components for F. tularensis to avoid host-cell defense mechanisms and successfully establish an infection. Although direct host-pathogen protein-protein binding is only one aspect of Francisella virulence, it is a critical component in directly manipulating and interfering with cellular processes in the host cell. C1 [Wallqvist, Anders; Memisevic, Vesna; Zavaljevski, Nela; Yu, Chenggang; Reifman, Jaques] US Army Med Res & Mat Command, Dept Def Biotechnol, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. [Pieper, Rembert; Rajagopala, Seesandra V.; Kwon, Keehwan] J Craig Venter Inst, Rockville, MD 20850 USA. [Hoover, Timothy A.] US Army Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. RP Reifman, J (reprint author), US Army Med Res & Mat Command, Dept Def Biotechnol, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. EM jaques.reifman.civ@mail.mil OI wallqvist, anders/0000-0002-9775-7469; Rajagopala, Seesandra/0000-0001-7176-5770 FU U.S. Defense Threat Reduction Agency Award [CBS.MEDBIO.02.10.BH.021]; U.S. Army Medical Research and Materiel Command (Ft. Detrick, MD) as part of the U.S. Army's Network Science Initiative FX This work was supported by U.S. Defense Threat Reduction Agency Award CBS. MEDBIO.02.10.BH.021 and by the U.S. Army Medical Research and Materiel Command (Ft. Detrick, MD) as part of the U.S. Army's Network Science Initiative. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or the U.S. Department of Defense. This paper has been approved for public release with unlimited distribution. NR 77 TC 1 Z9 1 U1 3 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2164 J9 BMC GENOMICS JI BMC Genomics PD DEC 29 PY 2015 VL 16 AR 1106 DI 10.1186/s12864-015-2351-1 PG 18 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA DM1GK UT WOS:000376093200001 PM 26714771 ER PT J AU Kilianski, A Carcel, P Yao, SJ Roth, P Schulte, J Donarum, GB Fochler, ET Hill, JM Liem, AT Wiley, MR Ladner, JT Pfeffer, BP Elliot, O Petrosov, A Jima, DD Vallard, TG Melendrez, MC Skowronski, E Quan, PL Lipkin, WI Gibbons, HS Hirschberg, DL Palacios, GF Rosenzweig, CN AF Kilianski, Andy Carcel, Patrick Yao, Shijie Roth, Pierce Schulte, Josh Donarum, Greg B. Fochler, Ed T. Hill, Jessica M. Liem, Alvin T. Wiley, Michael R. Ladner, Jason T. Pfeffer, Bradley P. Elliot, Oliver Petrosov, Alexandra Jima, Dereje D. Vallard, Tyghe G. Melendrez, Melanie C. Skowronski, Evan Quan, Phenix-Lan Lipkin, W. Ian Gibbons, Henry S. Hirschberg, David L. Palacios, Gustavo F. Rosenzweig, C. Nicole TI Pathosphere.org: pathogen detection and characterization through a web-based, open source informatics platform SO BMC BIOINFORMATICS LA English DT Article ID UNASSEMBLED SEQUENCING DATA; EBOLA-VIRUS; CLINICAL-SAMPLES; GENOMIC ANALYSIS; IDENTIFICATION; DISCOVERY; SURVEILLANCE; STRAIN; CHALLENGES; ALIGNMENT AB Background: The detection of pathogens in complex sample backgrounds has been revolutionized by wide access to next-generation sequencing (NGS) platforms. However, analytical methods to support NGS platforms are not as uniformly available. Pathosphere (found at Pathosphere.org) is a cloud based open sourced community tool that allows for communication, collaboration and sharing of NGS analytical tools and data amongst scientists working in academia, industry and government. The architecture allows for users to upload data and run available bioinformatics pipelines without the need for onsite processing hardware or technical support. Results: The pathogen detection capabilities hosted on Pathosphere were tested by analyzing pathogen-containing samples sequenced by NGS with both spiked human samples as well as human and zoonotic host backgrounds. Pathosphere analytical pipelines developed by Edgewood Chemical Biological Center (ECBC) identified spiked pathogens within a common sample analyzed by 454, Ion Torrent, and Illumina sequencing platforms. ECBC pipelines also correctly identified pathogens in human samples containing arenavirus in addition to animal samples containing flavivirus and coronavirus. These analytical methods were limited in the detection of sequences with limited homology to previous annotations within NCBI databases, such as parvovirus. Utilizing the pipeline-hosting adaptability of Pathosphere, the analytical suite was supplemented by analytical pipelines designed by the United States Army Medical Research Insititute of Infectious Diseases and Walter Reed Army Institute of Research (USAMRIID-WRAIR). These pipelines were implemented and detected parvovirus sequence in the sample that the ECBC iterative analysis previously failed to identify. Conclusions: By accurately detecting pathogens in a variety of samples, this work demonstrates the utility of Pathosphere and provides a platform for utilizing, modifying and creating pipelines for a variety of NGS technologies developed to detect pathogens in complex sample backgrounds. These results serve as an exhibition for the existing pipelines and web-based interface of Pathosphere as well as the plug-in adaptability that allows for integration of newer NGS analytical software as it becomes available. C1 [Kilianski, Andy; Roth, Pierce; Hill, Jessica M.; Liem, Alvin T.; Gibbons, Henry S.; Rosenzweig, C. Nicole] Edgewood Chem & Biol Ctr, Biosci Div, Aberdeen Proving Ground, MD 21010 USA. [Carcel, Patrick; Yao, Shijie; Roth, Pierce; Schulte, Josh; Donarum, Greg B.; Fochler, Ed T.; Hill, Jessica M.; Liem, Alvin T.] OptiMetrics Inc, Abingdon, MD USA. [Wiley, Michael R.; Ladner, Jason T.; Pfeffer, Bradley P.; Palacios, Gustavo F.] US Med Res Inst Infect Dis, Ctr Genome Sci, Frederick, MD USA. [Elliot, Oliver] Columbia Univ, Dept Biomed Informat, New York, NY USA. [Jima, Dereje D.; Vallard, Tyghe G.; Melendrez, Melanie C.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA. [Skowronski, Evan] TMG Biosci LLC, Austin, TX USA. [Petrosov, Alexandra; Quan, Phenix-Lan; Lipkin, W. Ian; Hirschberg, David L.] Columbia Univ, Ctr Infect & Immun, New York, NY USA. [Yao, Shijie] LBNL, Joint Genome Inst, Dept Energy, Berkeley, CA USA. [Hirschberg, David L.] Univ Washington, Dept Interdisciplinary Arts & Sci, Tacoma, WA USA. RP Rosenzweig, CN (reprint author), Edgewood Chem & Biol Ctr, Biosci Div, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM carolyn.n.rosenzweig.civ@mail.mil RI Palacios, Gustavo/I-7773-2015; OI Palacios, Gustavo/0000-0001-5062-1938; Melendrez, Melanie/0000-0002-4811-4467; Kilianski, Andy/0000-0002-2350-0142 FU National Academy of Science FX This work was made possible by the Defense Threat Reduction Agency effort CB3576 to C.N.R and CB2847 to H.S.G and C.N.R. and CB3575 to W.I.L. A.K is supported by the National Academy of Science and DTRA as a National Research Council (NRC) fellow. The authors report no competing interests for this work. Conclusions and opinions presented here are those of the authors and are not the official policy of the US Army, ECBC, or the US Government. Information in this report is cleared for public release and distribution is unlimited. NR 59 TC 3 Z9 3 U1 5 U2 20 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2105 J9 BMC BIOINFORMATICS JI BMC Bioinformatics PD DEC 29 PY 2015 VL 16 AR 416 DI 10.1186/s12859-015-0840-5 PG 12 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Mathematical & Computational Biology GA CZ6RU UT WOS:000367229200003 PM 26714571 ER PT J AU Izvekov, S Rice, BM AF Izvekov, Sergei Rice, Betsy M. TI A new parameter-free soft-core potential for silica and its application to simulation of silica anomalies SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID MOLECULAR-DYNAMICS SIMULATION; X-RAY-DIFFRACTION; HIGH-PRESSURE; LIQUID SILICA; SUPERCOOLED WATER; FORCE-FIELD; SIO2 GLASS; COMPUTER-SIMULATION; RAMAN-SPECTROSCOPY; ELASTIC PROPERTIES AB A core-softening of the effective interaction between oxygen atoms in water and silica systems and its role in developing anomalous thermodynamic, transport, and structural properties have been extensively debated. For silica, the progress with addressing these issues has been hampered by a lack of effective interaction models with explicit core-softening. In this work, we present an extension of a two-body soft-core interatomic force field for silica recently reported by us [S. Izvekov and B. M. Rice, J. Chem. Phys. 136(13), 134508 (2012)] to include three-body forces. Similar to two-body interaction terms, the three-body terms are derived using parameter-free force-matching of the interactions from ab initio MD simulations of liquid silica. The derived shape of the O-Si-O three-body potential term affirms the existence of repulsion softening between oxygen atoms at short separations. The new model shows a good performance in simulating liquid, amorphous, and crystalline silica. By comparing the soft-core model and a similar model with the soft-core suppressed, we demonstrate that the topology reorganization within the local tetrahedral network and the O-O core-softening are two competitive mechanisms responsible for anomalous thermodynamic and kinetic behaviors observed in liquid and amorphous silica. The studied anomalies include the temperature of density maximum locus and anomalous diffusivity in liquid silica, and irreversible densification of amorphous silica. We show that the O-O core-softened interaction enhances the observed anomalies primarily through two mechanisms: facilitating the defect driven structural rearrangements of the silica tetrahedral network and modifying the tetrahedral ordering induced interactions toward multiple characteristic scales, the feature which underlies the thermodynamic anomalies. C1 [Izvekov, Sergei; Rice, Betsy M.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Izvekov, S (reprint author), US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM sergiy.izvyekov.civ@mail.mil FU ARL Director's Strategic Initiative "Multi-Scale Modeling of Non-Crystalline Ceramics (Glass)"; DoD High Performance Computing Modernization Program Software Application Institute for Multi-Scale Reactive Modeling of Insensitive Munitions FX The authors wish to thank Dr. George Gazonas, Dr. Ed Byrd, and Dr. Scott Weingarten for helpful discussions. This research was partially supported by the ARL Director's Strategic Initiative "Multi-Scale Modeling of Non-Crystalline Ceramics (Glass)" and the DoD High Performance Computing Modernization Program Software Application Institute for Multi-Scale Reactive Modeling of Insensitive Munitions (2008-2014). NR 152 TC 1 Z9 1 U1 7 U2 25 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-9606 EI 1089-7690 J9 J CHEM PHYS JI J. Chem. Phys. PD DEC 28 PY 2015 VL 143 IS 24 AR 244506 DI 10.1063/1.4937394 PG 18 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA DE1UV UT WOS:000370412900112 PM 26723691 ER PT J AU Sunday, KJ Darling, KA Hanejko, FG Anasori, B Liu, YC Taheri, ML AF Sunday, Katie Jo Darling, Kristopher A. Hanejko, Francis G. Anasori, Babak Liu, Yan-Chun Taheri, Mitra L. TI Al2O3 "self-coated" iron powder composites via mechanical milling SO JOURNAL OF ALLOYS AND COMPOUNDS LA English DT Article DE Composite materials; Powder metallurgy; SEM; Magnetization ID SOFT-MAGNETIC COMPOSITES; ALUMINA; POLYEPOXY; PARTICLES; PHOSPHATE; OXIDATION; SILICA AB Electrically insulated ferrous powders permit isotropic magnetic flux, lower core losses, and structural freedom for state-of-the-art electromagnetic (EM) core and device designs. Many current coating materials are limited by low melting temperatures, which leads to insufficient insulation of powders, resulting in metal-on-metal contact. Use of a high-temperature coating material, such as alumina, could alleviate these issues. In this work, iron powder was mechanically milled with alumina media, to yield plastically deformed, alumina-coated iron particles with improved magnetic saturation, elastic modulus, and hardness. Various milling times and media ball sizes are investigated to maintain particle size, insulate powders uniformly, and optimize properties after compaction and curing. We found that longer milling times yielded more dense powder coatings and lower magnetic saturation. (C) 2015 Elsevier B.V. All rights reserved. C1 [Sunday, Katie Jo; Anasori, Babak; Liu, Yan-Chun; Taheri, Mitra L.] Univ Penn, Dept Mat Sci & Engn, Philadelphia, PA 19104 USA. [Darling, Kristopher A.] US Army Res Lab, Weap & Mat Res Div, Aberdeen, MD 21005 USA. [Hanejko, Francis G.] Hoeganaes Corp, Cinnaminson, NJ 08077 USA. RP Taheri, ML (reprint author), Univ Penn, Dept Mat Sci & Engn, 3231 Walnut St, Philadelphia, PA 19104 USA. EM mtaheri@coe.drexel.edu RI Anasori, Babak/O-4828-2015 OI Anasori, Babak/0000-0002-1955-253X FU National Science Foundation [235672] FX Authors KJS and MLT acknowledge funding from the National Science Foundation under Grant No. 235672. We thank Steve May for access to the vibrating sample magnetometer, Christopher M. Barr and Wayne Harlow for various SEM images, and the Centralized Research Facilities for access to the x-ray diffractometer and scanning electron microscope at Drexel University. NR 36 TC 3 Z9 3 U1 5 U2 34 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0925-8388 EI 1873-4669 J9 J ALLOY COMPD JI J. Alloy. Compd. PD DEC 25 PY 2015 VL 653 BP 61 EP 68 DI 10.1016/j.jallcom.2015.08.260 PG 8 WC Chemistry, Physical; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Chemistry; Materials Science; Metallurgy & Metallurgical Engineering GA CU1GZ UT WOS:000363270000009 ER PT J AU Draper, SJ Angov, E Horii, T Miller, LH Srinivasan, P Theisen, M Biswas, S AF Draper, Simon J. Angov, Evelina Horii, Toshihiro Miller, Louis H. Srinivasan, Prakash Theisen, Michael Biswas, Sumi TI Recent advances in recombinant protein-based malaria vaccines SO VACCINE LA English DT Article DE Malaria; Recombinant protein; Vaccine; Adjuvant; Plasmodium falciparum; Antibody ID BLOOD-STAGE MALARIA; APICAL MEMBRANE ANTIGEN-1; TRANSMISSION-BLOCKING VACCINE; GLUTAMATE-RICH PROTEIN; MEROZOITE SURFACE PROTEIN-3; PLASMODIUM-FALCIPARUM INVASION; HOST-CELL INVASION; NATURALLY ACQUIRED ANTIBODIES; MONTANIDE ISA 51; CLINICAL MALARIA AB Plasmodium parasites are the causative agent of human malaria, and the development of a highly effective vaccine against infection, disease and transmission remains a key priority. It is widely established that multiple stages of the parasite's complex lifecycle within the human host and mosquito vector are susceptible to vaccine-induced antibodies. The mainstay approach to antibody induction by subunit vaccination has been the delivery of protein antigen formulated in adjuvant. Extensive efforts have been made in this endeavor with respect to malaria vaccine development, especially with regard to target antigen discovery, protein expression platforms, adjuvant testing, and development of soluble and virus-like particle (VLP) delivery platforms. The breadth of approaches to protein-based vaccines is continuing to expand as innovative new concepts in next-generation subunit design are explored, with the prospects for the development of a highly effective multi-component/multi-stage/multi-antigen formulation seeming ever more likely. This review will focus on recent progress in protein vaccine design, development and/or clinical testing for a number of leading malaria antigens from the sporozoite-, merozoite- and sexual-stages of the parasite's lifecycle-including PfCeITOS, PfMSP1, PfAMA1, PfRH5, PfSERA5, PfGLURP, PfMSP3, Pfs48/45 and Pfs25. Future prospects and challenges for the development, production, human delivery and assessment of protein-based malaria vaccines are discussed. (C) 2015 The Authors. Published by Elsevier Ltd. C1 [Draper, Simon J.; Biswas, Sumi] Univ Oxford, Jenner Inst, Oxford OX3 7DQ, England. [Angov, Evelina] Walter Reed Army Inst Res, US Mil Malaria Res Program, Silver Spring, MD 20910 USA. [Horii, Toshihiro] Osaka Univ, Microbial Dis Res Inst, Dept Mol Protozool, Suita, Osaka 561873, Japan. [Miller, Louis H.; Srinivasan, Prakash] NIAID, Malaria Cell Biol Sect, Lab Malaria & Vector Res, NIH, Rockville, MD 20852 USA. [Theisen, Michael] Statens Serum Inst, Dept Congenital Disorders, DK-2300 Copenhagen, Denmark. [Theisen, Michael] Univ Copenhagen, Rigshosp, Ctr Med Parasitol, Dept Int Hlth Immunol & Microbiol, DK-2100 Copenhagen, Denmark. [Theisen, Michael] Univ Copenhagen, Rigshosp, Dept Infect Dis, DK-2100 Copenhagen, Denmark. RP Draper, SJ (reprint author), Univ Oxford, Jenner Inst, Old Rd Campus Res Bldg,Roosevelt Dr, Oxford OX3 7DQ, England. EM simon.draper@ndm.ox.ac.uk OI Draper, Simon/0000-0002-9415-1357 FU UK Medical Research Council (MRC) [G1000527]; U.S. Military Infectious Diseases Research Program (MIDRP); U.S. Agency for International Development (USAID) through an Interagency Agreement (IAA); Ministry of Education, Culture, Sports, Science and Technology of Japan [24249024]; Global Health Innovative Technology Fund [GHIT RFP 2013-001]; Intramural Research Program of the Division of Intramtral Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, USA; USAID; EU FP7 Seventh Framework Program Theme [Health-2009-2.3.2-5, 242079]; Danish Council for Strategic research [13127]; European and Developing Countries Clinical Trials Partnership (EDCTP) [IP.2007.3110.001] FX SJD is a Jenner Investigator, a Lister Institute Research Prize Fellow and a UK Medical Research Council (MRC) Career Development Fellow [G1000527; this Fellowship is jointly funded by the UK MRC and the UK Department for International Development (DFID) under the MRC/DFID Concordat agreement]. EA acknowledges funding from the U.S. Military Infectious Diseases Research Program (MIDRP) and the U.S. Agency for International Development (USAID) through an Interagency Agreement (IAA). TH acknowledges funding from Grant-in-Aid for Scientific Research (A) [grant number 24249024] from the Ministry of Education, Culture, Sports, Science and Technology of Japan; and Global Health Innovative Technology Fund [GHIT RFP 2013-001]. LHM and PS are supported by the Intramural Research Program of the Division of Intramtral Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, USA; and also acknowledge support from USAID. MT acknowledges funding from the EU FP7 Seventh Framework Program Theme Health-2009-2.3.2-5 [grant 242079]; the Danish Council for Strategic research [grant 13127]; and the European and Developing Countries Clinical Trials Partnership (EDCTP) [grant IP.2007.3110.001]. SB is a NDM Leadership Fellow and Junior Research Fellow of St Catherine's College, Oxford University. NR 198 TC 11 Z9 11 U1 8 U2 25 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD DEC 22 PY 2015 VL 33 IS 52 SI SI BP 7433 EP 7443 DI 10.1016/j.vaccine.2015.09.093 PG 11 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA DA0MR UT WOS:000367491700003 PM 26458807 ER PT J AU Ouattara, A Barry, AE Dutta, S Remarque, EJ Beeson, JG Plowe, CV AF Ouattara, Amed Barry, Alyssa E. Dutta, Sheetij Remarque, Edmond J. Beeson, James G. Plowe, Christopher V. TI Designing malaria vaccines to circumvent antigen variability SO VACCINE LA English DT Article DE Malaria; Vaccine; Diversity; Heterologous; Allele-specific efficacy; Cross-protection ID APICAL MEMBRANE ANTIGEN-1; PLASMODIUM-FALCIPARUM MALARIA; ALLELE-SPECIFIC EFFICACY; GENETIC DIVERSITY; PREERYTHROCYTIC STAGES; POPULATION-STRUCTURE; REVERSE VACCINOLOGY; SPOROZOITE VACCINE; HUMAN IMMUNITY; IMMUNIZATION AB Prospects for malaria eradication will be greatly enhanced by an effective vaccine, but parasite genetic diversity poses a major impediment to malaria vaccine efficacy. In recent pre-clinical and field trials, vaccines based on polymorphic Plasmodium falciparum antigens have shown efficacy only against homologous strains, raising the specter of allele-specific immunity such as that which plagues vaccines against influenza and HIV. The most advanced malaria vaccine, RTS,S, targets relatively conserved epitopes on the P. falciparum circumsporozoite protein. After more than 40 years of development and testing, RTS,S, has shown significant but modest efficacy against clinical malaria in phase 2 and 3 trials. Ongoing phase 2 studies of an irradiated sporozoite vaccine will ascertain whether the full protection against homologous experimental malaria challenge conferred by high doses of a whole organism vaccine can provide protection against diverse strains in the field. Here we review and evaluate approaches being taken to design broadly cross-protective malaria vaccines. (C) 2015 Published by Elsevier Ltd. C1 [Ouattara, Amed; Plowe, Christopher V.] Univ Maryland, Sch Med, Inst Global Hlth, Baltimore, MD 21201 USA. [Ouattara, Amed; Plowe, Christopher V.] Univ Maryland, Sch Med, Howard Hughes Med Inst, Baltimore, MD 21201 USA. [Ouattara, Amed] Univ Sci Techn & Technol, Malaria Res & Training Ctr, Bamako, Mali. [Barry, Alyssa E.] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Div Populat Hlth & Immun, Parkville, Vic 3050, Australia. [Barry, Alyssa E.] Univ Melbourne, Dept Med Biol, Melbourne, Vic, Australia. [Dutta, Sheetij] Walter Reed Army Inst Res, Silver Spring, MD USA. [Remarque, Edmond J.] Biomed Primate Res Ctr, Rijswijk, Netherlands. [Beeson, James G.] Burnet Inst, Melbourne, Vic, Australia. [Beeson, James G.] Monash Univ, Dept Microbiol, Clayton, Vic 3800, Australia. RP Plowe, CV (reprint author), Univ Maryland, Sch Med, 685 West Baltimore St,HSF1-480, Baltimore, MD 21201 USA. EM aouattara@medicine.umaryland.edu; barry@wehi.edu.au; sheetij.dutta.civ@mail.mil; remarque@bprc.nl; beeson@burnet.edu.au; cplowe@medicine.umaryland.edu FU Howard Hughes Medical Institute; National Institute for Allergy and Infectious Diseases, U.S. National Institutes of Health; Victorian State Government; Australian Government NHMRC IRIISS FX AO and CVP are supported by the Howard Hughes Medical Institute and the National Institute for Allergy and Infectious Diseases, U.S. National Institutes of Health. AEB and JB acknowledge the support of the Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS. NR 81 TC 2 Z9 2 U1 4 U2 11 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD DEC 22 PY 2015 VL 33 IS 52 SI SI BP 7506 EP 7512 DI 10.1016/j.vaccine.2015.09.110 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA DA0MR UT WOS:000367491700012 PM 26475447 ER PT J AU Wu, YM Narum, DL Fleury, S Jennings, G Yadava, A AF Wu, Yimin Narum, David L. Fleury, Sylvain Jennings, Gary Yadava, Anjali TI Particle-based platforms for malaria vaccines SO VACCINE LA English DT Article DE Malaria; Vaccine; Particle; Delivery; Adjuvant ID TRANSMISSION-BLOCKING VACCINE; EMULSION-BASED ADJUVANTS; AERUGINOSA EXOPROTEIN-A; IMMUNE-RESPONSES; ANTIBODY-RESPONSE; THERAPEUTIC VACCINES; FALCIPARUM-MALARIA; CONJUGATE VACCINES; RHESUS MACAQUES; EPITOPE DENSITY AB Recombinant subunit vaccines in general are poor immunogens likely due to the small size of peptides and proteins, combined with the lack or reduced presentation of repetitive motifs and missing complementary signal(s) for optimal triggering of the immune response. Therefore, recombinant subunit vaccines require enhancement by vaccine delivery vehicles in order to attain adequate protective immunity. Particle-based delivery platforms, including particulate antigens and particulate adjuvants, are promising delivery vehicles for modifying the way in which immunogens are presented to both the innate and adaptive immune systems. These particle delivery platforms can also co-deliver non-specific immunostimodulators as additional adjuvants. This paper reviews efforts and advances of the Particle-based delivery platforms in development of vaccines against malaria, a disease that claims over 600,000 lives per year, most of them are children under 5 years of age in sub-Sahara Africa. (C) 2015 Elsevier Ltd. C1 [Wu, Yimin; Narum, David L.] NIAID, Lab Malaria Immunol & Vaccinol, Rockville, MD 20892 USA. [Fleury, Sylvain] Mymetics Corp, CH-1066 Epalinges, Switzerland. [Jennings, Gary] Cytos Biotechnol AG, CH-8952 Schlieren, Switzerland. [Yadava, Anjali] Walter Reed Army Inst Res, Malaria Vaccine Branch, US Mil Malaria Vaccine Program, Silver Spring, MD USA. RP Wu, YM (reprint author), PATH Malaria Vaccine Initiat, 455 Massachusetts Ave, Washington, DC 20001 USA. EM ywu@path.org FU Division of Intramural Research, NIAID, NIH FX The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of either the Department of Health and Human Services, the Department of the Army, the Department of Defense or the U.S. Government. YW and DLN are supported by Division of Intramural Research, NIAID, NIH. NR 69 TC 2 Z9 2 U1 3 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD DEC 22 PY 2015 VL 33 IS 52 SI SI BP 7518 EP 7524 DI 10.1016/j.vaccine.2015.09.097 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA DA0MR UT WOS:000367491700014 PM 26458803 ER PT J AU Prokop, CJ Crider, BP Liddick, SN Ayangeakaa, AD Carpenter, MP Carroll, JJ Chen, J Chiara, CJ David, HM Dombos, AC Go, S Harker, J Janssens, RVF Larson, N Lauritsen, T Lewis, R Quinn, SJ Recchia, F Seweryniak, D Spyrou, A Suchyta, S Walters, WB Zhu, S AF Prokop, C. J. Crider, B. P. Liddick, S. N. Ayangeakaa, A. D. Carpenter, M. P. Carroll, J. J. Chen, J. Chiara, C. J. David, H. M. Dombos, A. C. Go, S. Harker, J. Janssens, R. V. F. Larson, N. Lauritsen, T. Lewis, R. Quinn, S. J. Recchia, F. Seweryniak, D. Spyrou, A. Suchyta, S. Walters, W. B. Zhu, S. TI New low-energy 0(+) state and shape coexistence in Ni-70 SO PHYSICAL REVIEW C LA English DT Article ID BETA-DECAY; ISOTOPES; NUCLEI; SPECTROSCOPY; ISOMERS; BANDS; ODD AB In recent models, the neutron-rich Ni isotopes around N = 40 are predicted to exhibit multiple low-energy excited 0(+) states attributed to neutron and proton excitations across both the N = 40 and Z = 28 shell gaps. In Ni-68, the three observed 0(+) states have been interpreted in terms of triple shape coexistence between spherical, oblate, and prolate deformed shapes. In the present work a new (0(2)(+)) state at an energy of 1567 keV has been discovered in Ni-70 by using beta-delayed, gamma-ray spectroscopy following the decay of Co-70. The precipitous drop in the energy of the prolate-deformed 0(+) level between Ni-68 and Ni-70 with the addition of two neutrons compares favorably with results of Monte Carlo shell-model calculations carried out in the large fpg(9/2)d(5/2) model space, which predict a 0(2)(+) state at 1525 keV in Ni-70. The result extends the shape-coexistence picture in the region to Ni-70 and confirms the importance of the role of the tensor component of the monopole interaction in describing the structure of neutron-rich nuclei. C1 [Prokop, C. J.; Crider, B. P.; Liddick, S. N.; Chen, J.; Dombos, A. C.; Larson, N.; Lewis, R.; Quinn, S. J.; Spyrou, A.] Michigan State Univ, Natl Supercond Cyclotron Lab, E Lansing, MI 48824 USA. [Prokop, C. J.; Liddick, S. N.; Larson, N.; Lewis, R.] Michigan State Univ, Dept Chem, E Lansing, MI 48824 USA. [Ayangeakaa, A. D.; Carpenter, M. P.; David, H. M.; Harker, J.; Janssens, R. V. F.; Lauritsen, T.; Seweryniak, D.; Zhu, S.] Argonne Natl Lab, Div Phys, Argonne, IL 60439 USA. [Carroll, J. J.] US Army, Res Lab, Adelphi, MD 20783 USA. [Chiara, C. J.] US Army, Res Lab, Oak Ridge Associated Univ Fellowship Program, Adelphi, MD 20783 USA. [Dombos, A. C.; Quinn, S. J.; Spyrou, A.] Michigan State Univ, Dept Phys, E Lansing, MI 48824 USA. [Go, S.] Univ Tennessee, Dept Phys & Astron, Knoxville, TN 37996 USA. [Harker, J.; Walters, W. B.] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA. [Recchia, F.] Univ Padua, Dipartimento Fis & Astron, I-35131 Padua, Italy. [Suchyta, S.] Univ Calif Berkeley, Dept Nucl Engn, Berkeley, CA 94720 USA. RP Prokop, CJ (reprint author), Michigan State Univ, Natl Supercond Cyclotron Lab, E Lansing, MI 48824 USA. EM prokop@nscl.msu.edu RI Larson, Nicole/S-5997-2016 OI Larson, Nicole/0000-0003-0292-957X FU National Science Foundation (NSF) [PHY-1102511]; Department of Energy National Nuclear Security Administration (NNSA) [DE-NA0000979, DE-NA0002132, DE-FG52-08NA28552]; U.S Department of Energy, Office of Science, Office of Nuclear Physics [DE-AC-06CH11357, DE-FG02-94ER40834, DE-FG02-96ER40983]; U.S. Army Research Laboratory [W911NF-12-2-0019] FX This work was supported in part by National Science Foundation (NSF) under contract No. PHY-1102511, by the Department of Energy National Nuclear Security Administration (NNSA) under Awards No. DE-NA0000979, No. DE-NA0002132, and No. DE-FG52-08NA28552, by the U.S Department of Energy, Office of Science, Office of Nuclear Physics, under Contract No. DE-AC-06CH11357 (ANL) and Grants No. DE-FG02-94ER40834 (Maryland) and No. DE-FG02-96ER40983 (UT), and by the U.S. Army Research Laboratory under Cooperative Agreement W911NF-12-2-0019. NR 41 TC 10 Z9 10 U1 2 U2 8 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0556-2813 EI 1089-490X J9 PHYS REV C JI Phys. Rev. C PD DEC 21 PY 2015 VL 92 IS 6 AR 061302 DI 10.1103/PhysRevC.92.061302 PG 6 WC Physics, Nuclear SC Physics GA CZ4IW UT WOS:000367067700001 ER PT J AU Riley, MC Wilkes, RP AF Riley, Matthew C. Wilkes, Rebecca P. TI Sequencing of emerging canine distemper virus strain reveals new distinct genetic lineage in the United States associated with disease in wildlife and domestic canine populations SO VIROLOGY JOURNAL LA English DT Article DE Canine distemper virus; CDV; Genome sequencing; New CDV strain; Phylogenetics; Vaccination; Vaccines ID VACCINATED DOGS; IDENTIFICATION; HEMAGGLUTININ; INFECTION; VIRULENCE; REGION AB Background: Recent outbreaks of canine distemper have prompted examination of strains from clinical samples submitted to the University of Tennessee College of Veterinary Medicine (UTCVM) Clinical Virology Lab. We previously described a new strain of CDV that significantly diverged from all genotypes reported to date including America 2, the genotype proposed to be the main lineage currently circulating in the US. The aim of this study was to determine when this new strain appeared and how widespread it is in animal populations, given that it has also been detected in fully vaccinated adult dogs. Additionally, we sequenced complete viral genomes to characterize the strain and determine if variation is confined to known variable regions of the genome or if the changes are also present in more conserved regions. Methods: Archived clinical samples were genotyped using real-time RT-PCR amplification and sequencing. The genomes of two unrelated viruses from a dog and fox each from a different state were sequenced and aligned with previously published genomes. Phylogenetic analysis was performed using coding, non-coding and genome-length sequences. Virus neutralization assays were used to evaluate potential antigenic differences between this strain and a vaccine strain and mixed ANOVA test was used to compare the titers. Results: Genotyping revealed this strain first appeared in 2011 and was detected in dogs from multiple states in the Southeast region of the United States. It was the main strain detected among the clinical samples that were typed from 2011-2013, including wildlife submissions. Genome sequencing demonstrated that it is highly conserved within a new lineage and preliminary serologic testing showed significant differences in neutralizing antibody titers between this strain and the strain commonly used in vaccines. Conclusion: This new strain represents an emerging CDV in domestic dogs in the US, may be associated with a stable reservoir in the wildlife population, and could facilitate vaccine escape. C1 [Riley, Matthew C.; Wilkes, Rebecca P.] Univ Tennessee, Dept Biomed & Diagnost Sci, Coll Vet Med, Knoxville, TN 37996 USA. [Riley, Matthew C.] US Army, Med Serv Corps, Salt Lake City, UT USA. RP Wilkes, RP (reprint author), Univ Tennessee, Dept Biomed & Diagnost Sci, Coll Vet Med, 2407 River Dr, Knoxville, TN 37996 USA. EM beckpen@uga.edu FU Department of Biomedical and Diagnostic Sciences Education Advancement and Research Fund, College of Veterinary Medicine, The University of Tennessee FX This work was supported by the Department of Biomedical and Diagnostic Sciences Education Advancement and Research Fund, College of Veterinary Medicine, The University of Tennessee. NR 34 TC 2 Z9 2 U1 5 U2 16 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1743-422X J9 VIROL J JI Virol. J. PD DEC 18 PY 2015 VL 12 AR 219 DI 10.1186/s12985-015-0445-7 PG 10 WC Virology SC Virology GA CZ1UF UT WOS:000366890300001 PM 26683832 ER PT J AU Morris, JR Russell, JN Karwacki, CJ AF Morris, John R. Russell, John N., Jr. Karwacki, Christopher J. TI An Operando View of the Nanoscale SO JOURNAL OF PHYSICAL CHEMISTRY LETTERS LA English DT Editorial Material ID SURFACE-CHEMISTRY; CATALYSTS; EVOLUTION; XPS; CO2 C1 [Morris, John R.] Virginia Tech, Dept Chem, Blacksburg, VA 24061 USA. [Russell, John N., Jr.] Naval Res Lab, Div Chem, Washington, DC 20375 USA. [Karwacki, Christopher J.] US Army, Protect & Decontaminat Div, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Karwacki, CJ (reprint author), US Army, Protect & Decontaminat Div, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM christopher.j.karwacki.civ@mail.mil NR 24 TC 1 Z9 1 U1 5 U2 25 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1948-7185 J9 J PHYS CHEM LETT JI J. Phys. Chem. Lett. PD DEC 17 PY 2015 VL 6 IS 24 BP 4923 EP 4926 DI 10.1021/acs.jpclett.5b02330 PG 4 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Atomic, Molecular & Chemical SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA CZ1SQ UT WOS:000366886000008 PM 26722703 ER PT J AU Mate, SE Kugelman, JR Nyenswah, TG Ladner, JT Wiley, MR Cordier-Lassalle, T Christie, A Schroth, GP Gross, SM Davies-Wayne, GJ Shinde, SA Murugan, R Sieh, SB Badio, M Fakoli, L Taweh, F de Wit, E van Doremalen, N Munster, VJ Pettitt, J Prieto, K Humrighouse, BW Stroher, U DiClaro, JW Hensley, LE Schoepp, RJ Safronetz, D Fair, J Kuhn, JH Blackley, DJ Laney, AS Williams, DE Lo, T Gasasira, A Nichol, ST Formenty, P Kateh, FN De Cock, KM Bolay, F Sanchez-Lockhart, M Palacios, G AF Mate, S. E. Kugelman, J. R. Nyenswah, T. G. Ladner, J. T. Wiley, M. R. Cordier-Lassalle, T. Christie, A. Schroth, G. P. Gross, S. M. Davies-Wayne, G. J. Shinde, S. A. Murugan, R. Sieh, S. B. Badio, M. Fakoli, L. Taweh, F. de Wit, E. van Doremalen, N. Munster, V. J. Pettitt, J. Prieto, K. Humrighouse, B. W. Stroeher, U. DiClaro, J. W. Hensley, L. E. Schoepp, R. J. Safronetz, D. Fair, J. Kuhn, J. H. Blackley, D. J. Laney, A. S. Williams, D. E. Lo, T. Gasasira, A. Nichol, S. T. Formenty, P. Kateh, F. N. De Cock, K. M. Bolay, F. Sanchez-Lockhart, M. Palacios, G. TI Molecular Evidence of Sexual Transmission of Ebola Virus SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID SIERRA-LEONE; OUTBREAK; LIBERIA; CONGO; PERSISTENCE; EVOLUTION; DISEASE; KIKWIT; GUINEA AB A suspected case of sexual transmission from a male survivor of Ebola virus disease (EVD) to his female partner (the patient in this report) occurred in Liberia in March 2015. Ebola virus (EBOV) genomes assembled from blood samples from the patient and a semen sample from the survivor were consistent with direct transmission. The genomes shared three substitutions that were absent from all other Western African EBOV sequences and that were distinct from the last documented transmission chain in Liberia before this case. Combined with epidemiologic data, the genomic analysis provides evidence of sexual transmission of EBOV and evidence of the persistence of infective EBOV in semen for 179 days or more after the onset of EVD. C1 [Mate, S. E.; Kugelman, J. R.; Ladner, J. T.; Wiley, M. R.; Prieto, K.; Sanchez-Lockhart, M.; Palacios, G.] US Army Med Res Inst Infect Dis, Ctr Genome Sci, Frederick, MD 21702 USA. [Schoepp, R. J.] US Army Med Res Inst Infect Dis, Diagnost Syst Div, Frederick, MD 21702 USA. [Pettitt, J.; Hensley, L. E.; Kuhn, J. H.] NIAID, Div Clin Res, Integrated Res Facil Ft Detrick, NIH, Frederick, MD USA. [Nyenswah, T. G.; Sieh, S. B.; Badio, M.; Kateh, F. N.] Minist Hlth & Social Welf, Monrovia, Liberia. [Davies-Wayne, G. J.; Murugan, R.] WHO, Monrovia, Liberia. [Fakoli, L.; Taweh, F.; Bolay, F.] Liberian Inst Biomed Res, Charlesville, Liberia. [Cordier-Lassalle, T.; Christie, A.; Formenty, P.] WHO, Geneva, Switzerland. [Christie, A.; Humrighouse, B. W.; Stroeher, U.; Blackley, D. J.; Laney, A. S.; Williams, D. E.; Lo, T.; Nichol, S. T.; De Cock, K. M.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Schroth, G. P.; Gross, S. M.] Illumina, San Diego, CA USA. [Shinde, S. A.] WHO, New Delhi, India. [de Wit, E.; van Doremalen, N.; Munster, V. J.; Safronetz, D.] NIAID, Rocky Mt Lab, Div Intramural Res, NIH, Hamilton, MT 59840 USA. [DiClaro, J. W.] Naval Med Res Unit 3, Cairo, Egypt. [Fair, J.] Fdn Merieux, Washington, DC USA. RP Palacios, G (reprint author), US Army Med Res Inst Infect Dis, 1425 Porter St,Rm 622, Frederick, MD 21702 USA. EM gustavo.f.palacios.ctr@us.army.mil RI Palacios, Gustavo/I-7773-2015; OI Palacios, Gustavo/0000-0001-5062-1938; de Wit, Emmie/0000-0002-9763-7758; Munster, Vincent/0000-0002-2288-3196 FU Defense Threat Reduction Agency FX Funded by the Defense Threat Reduction Agency and others. NR 22 TC 70 Z9 71 U1 2 U2 36 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD DEC 17 PY 2015 VL 373 IS 25 BP 2448 EP 2454 DI 10.1056/NEJMoa1509773 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA CY5QD UT WOS:000366461400011 PM 26465384 ER PT J AU Kim, HC Timmes, TC Dempsey, BA AF Kim, Hyun-Chul Timmes, Thomas C. Dempsey, Brian A. TI Simultaneous removal of phosphorus and EfOM using MIEX, coagulation, and low-pressure membrane filtration SO ENVIRONMENTAL TECHNOLOGY LA English DT Article DE magnetic ion exchange; in-line coagulation; membrane filtration; phosphorus; EfOM ID MAGNETIC ION-EXCHANGE; SOLUBLE MICROBIAL PRODUCTS; NATURAL ORGANIC-MATTER; WASTE-WATER; ADSORPTIVE CHARACTERISTICS; AQUEOUS-SOLUTIONS; SURFACE-WATER; PILOT-SCALE; HUMIC-ACID; ULTRAFILTRATION AB The feasibility of using magnetic ion exchange (MIEX) treatment, in-line alum coagulation, and low-pressure membrane filtration was investigated for the simultaneous removal of total phosphorus (TP) and effluent organic matter (EfOM) from biologically treated wastewater. The focus was also placed on minimizing fouling of polyvinylidene fluoride and polyethersulfone membranes, which are the most commonly used low-pressure membranes in new and retrofit wastewater treatment plants. MIEX alone was effective for the removal of EfOM, and MIEX plus a small alum dose was very effective in removing both EfOM and TP. MIEX removed phosphorus, but organic acids in EfOM were preferentially removed, and the effects of competing anions on the removal of EfOM were insignificant. All the pretreatment strategies decreased the resistance to filtration. The greatest decrease in fouling was achieved by using MIEX (15mLL(-1)) plus a very low dose of alum (approximate to 0.5mgAlL(-1)). Sweep floc coagulation using alum and without MIEX also significantly decreased fouling but did not effectively remove EfOM and produced high floc volume that could be problematic for inside-out hollow-fibre modules. The addition of these reagents into rapid mix followed by membrane filtration would provide operational simplicity and could be easily retrofitted at existing membrane filtration facilities. [GRAPHICS] . C1 [Kim, Hyun-Chul; Dempsey, Brian A.] Penn State Univ, Dept Civil & Environm Engn, University Pk, PA 16802 USA. [Timmes, Thomas C.] US Army, Ctr Environm Hlth Res, Ft Detrick, MD USA. RP Kim, HC (reprint author), Sejong Univ, Water Resources Res Inst, 98 Gunja Dong, Seoul 143747, South Korea. EM animaplus@hanmail.net FU U.S. Geological Survey under State Water Resources Research Institute Programme [2010PA124B] FX This work was supported by the U.S. Geological Survey under State Water Resources Research Institute Programme [2010PA124B]. NR 41 TC 1 Z9 1 U1 6 U2 19 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 0959-3330 EI 1479-487X J9 ENVIRON TECHNOL JI Environ. Technol. PD DEC 17 PY 2015 VL 36 IS 24 BP 3167 EP 3175 DI 10.1080/09593330.2015.1055819 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA CU7UY UT WOS:000363748500010 PM 26017783 ER PT J AU Niu, L Liu, XF Cong, CX Wu, CY Wu, D Chang, TR Wang, H Zeng, QS Zhou, JD Wang, XL Fu, W Yu, P Fu, QD Najmaei, S Zhang, ZH Yakobson, BI Tay, BK Zhou, W Jeng, HT Lin, H Sum, TC Jin, C He, HY Yu, T Liu, Z AF Niu, Lin Liu, Xinfeng Cong, Chunxiao Wu, Chunyang Wu, Di Chang, Tay Rong Wang, Hong Zeng, Qingsheng Zhou, Jiadong Wang, Xingli Fu, Wei Yu, Peng Fu, Qundong Najmaei, Sina Zhang, Zhuhua Yakobson, Boris I. Tay, Beng Kang Zhou, Wu Jeng, Horng Tay Lin, Hsin Sum, Tze Chien Jin, Chuanhong He, Haiyong Yu, Ting Liu, Zheng TI Controlled Synthesis of Organic/Inorganic van der Waals Solid for Tunable Light-Matter Interactions SO ADVANCED MATERIALS LA English DT Article ID HEXAGONAL BORON-NITRIDE; FIELD-EFFECT TRANSISTORS; GRAPHENE HETEROSTRUCTURES; EPITAXIAL-GROWTH; SOLAR-CELLS; THIN-FILMS; MOS2; HETEROJUNCTIONS; PEROVSKITES; ELECTRONICS C1 [Niu, Lin; Wang, Hong; Zeng, Qingsheng; Zhou, Jiadong; Fu, Wei; Yu, Peng; Fu, Qundong; He, Haiyong; Liu, Zheng] Nanyang Technol Univ, Sch Mat Sci & Engn, Singapore 639798, Singapore. [Liu, Xinfeng; Cong, Chunxiao; Sum, Tze Chien; Yu, Ting] Nanyang Technol Univ, Sch Phys & Math Sci, Singapore 637371, Singapore. [Liu, Xinfeng] Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China. [Wu, Chunyang; Jin, Chuanhong] Zhejiang Univ, State Key Lab Silicon Mat, Hangzhou 310027, Zhejiang, Peoples R China. [Wu, Chunyang; Jin, Chuanhong] Zhejiang Univ, Sch Mat Sci & Engn, Hangzhou 310027, Zhejiang, Peoples R China. [Wu, Di; Lin, Hsin] Natl Univ Singapore, Ctr Adv Mat 2D, Singapore 117542, Singapore. [Wu, Di; Lin, Hsin] Natl Univ Singapore, Dept Phys, Singapore 117542, Singapore. [Chang, Tay Rong; Jeng, Horng Tay] Natl Tsing Hua Univ, Dept Phys, Hsinchu 30013, Taiwan. [Wang, Xingli; Tay, Beng Kang; Liu, Zheng] Nanyang Technol Univ, Nanoelect Ctr Excellence, Sch Elect & Elect Engn, NOVITAS, Singapore 639798, Singapore. [Najmaei, Sina] US Army, Res Labs, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Zhang, Zhuhua; Yakobson, Boris I.] Rice Univ, Dept Mat Sci & Nanoengn, Houston, TX 77005 USA. [Zhou, Wu] Oak Ridge Natl Lab, Div Mat Sci & Technol, Oak Ridge, TN 37831 USA. RP He, HY (reprint author), Nanyang Technol Univ, Sch Mat Sci & Engn, Singapore 639798, Singapore. EM HYHe@ntu.edu.sg; YuTing@ntu.edu.sg; Z.Liu@ntu.edu.sg RI Zhou, Wu/D-8526-2011; Lin, Hsin/F-9568-2012; Chang, Tay-Rong/K-3943-2015; Jin, Chuanhong/I-6460-2015; Zhang, Zhuhua/E-8162-2012 OI Zhou, Wu/0000-0002-6803-1095; Lin, Hsin/0000-0002-4688-2315; Chang, Tay-Rong/0000-0003-1222-2527; Jin, Chuanhong/0000-0001-8845-5664; FU Singapore National Research Foundation (NRF) [NRF-RF2013-08]; Nanyang Technological University [M4081137.070, M4080514]; Ministry of Education AcRF Tier 2 [MOE2013-T2-1-081, MOE2014-T2-1-044]; Singapore NRF through Singapore-Berkeley Research Initiative for Sustainable Energy (SinBerRISE) CREATE Programme; Ministry of Education, Singapore [MOE2012-T2-2-049]; National Science Foundation of China [51222202, 51472215]; National Basic Research Program of China [2014CB932500, 2015CB921000]; Fundamental Research Funds for the Central Universities [2014XZZX003-07] FX L.N., X.L., C.C., and C.W. contributed equally to this work. This work was supported by the Singapore National Research Foundation (NRF) under RF Award No. NRF-RF2013-08, the start-up funding from Nanyang Technological University (M4081137.070 and M4080514), and the Ministry of Education AcRF Tier 2 Grants MOE2013-T2-1-081 and MOE2014-T2-1-044. X.L and T.C.S. also acknowledge the financial support by the Singapore NRF through the Singapore-Berkeley Research Initiative for Sustainable Energy (SinBerRISE) CREATE Programme. C.C and T.Y thank the support of Ministry of Education, Singapore (MOE2012-T2-2-049). C.W. and C.J. thank the Center for Electron Microscopy of Zhejiang University for the access to TEM facilities, and the financial support from the National Science Foundation of China (Grant Nos. 51222202 and 51472215), the National Basic Research Program of China (Grant Nos. 2014CB932500 and 2015CB921000), and the Fundamental Research Funds for the Central Universities (Grant No. 2014XZZX003-07). NR 49 TC 10 Z9 10 U1 30 U2 91 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 0935-9648 EI 1521-4095 J9 ADV MATER JI Adv. Mater. PD DEC 16 PY 2015 VL 27 IS 47 BP 7800 EP 7808 DI 10.1002/adma.201503367 PG 9 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA DA5IX UT WOS:000367837900015 PM 26505987 ER PT J AU Pittman, PR Reisler, RB Lindsey, CY Guerena, F Rivard, R Clizbe, DP Chambers, M Norris, S Smith, LA AF Pittman, Phillip R. Reisler, Ronald B. Lindsey, Changhong Y. Gueerena, Fernando Rivard, Robert Clizbe, Denise P. Chambers, Matthew Norris, Sarah Smith, Leonard A. TI Safety and immunogenicity of ricin vaccine, RVEC (TM), in a Phase 1 clinical trial SO VACCINE LA English DT Article DE Ricin vaccine; Recombinant vaccine; Clinical trial; Dose; Safety; Immune response ID PALMITYL TRANSFERASE DEFICIENCY; RIBOSOME-INACTIVATING PROTEINS; VASCULAR LEAK SYNDROME; N-GLYCOSIDASE ACTIVITY; A-CHAIN; SUBUNIT VACCINES; TOXIN; MICE; RNA; RHABDOMYOLYSIS AB Ricin is a potent toxin and potential bioterrorism weapon for which no specific licensed countermeasures are available. We report the safety and immunogenicity of the ricin vaccine RVEc (TM) in a Phase 1 (N = 30) multiple-dose, open-label, non-placebo-controlled, dose-escalating (20, 50, and 100 mu g), single-center study. Each subject in the 20- and 50-mu g dose groups (n = 10 for each group) received three injections at 4-week intervals and was observed carefully for untoward effects of the vaccine; blood was drawn at predetermined intervals after each dose for up to I year. RVEc (TM) was safe and well tolerated at the 20- and 50-mu g doses. The most common adverse events were pain at the injection site and headache. Of the 10 subjects who received a single 100-mu g dose, two developed elevated creatine phosphokinase levels, which resolved without sequelae. No additional doses were administered to subjects in the 100-mu g group. Immunogenicity of the vaccine was evaluated by measuring antibody response using the well standardized enzyme-linked immunosorbent assay (ELISA) and toxin neutralization assay (TNA). Of the subjects in the 20- and 50-mu g dose groups, 100% achieved ELISA anti-ricin IgG titers of 1:500 to 1:121,500 and 50% produced neutralizing anti-ricin antibodies measurable by TNA. Four subjects in the 50-mu g group received a single booster dose of RVEc (TM) 20-21 months after the initial dose. The single booster was safe and well tolerated, resulting in no serious adverse events, and significantly enhanced immunogenicity of the vaccine in human subjects. Each booster recipient developed a robust anamnestic response with ELISA anti-ricin IgG titers of 1:13,500 to 1:121,500 and neutralizing antibody titers of 1:400 to 1:3200. Future studies will attempt to optimize dose, scheduling, and route of administration. This study is registered at clinicaltrials.gov (NCT01317667 and NCT01846104). Published by Elsevier Ltd. C1 [Pittman, Phillip R.; Lindsey, Changhong Y.; Rivard, Robert; Clizbe, Denise P.; Chambers, Matthew; Norris, Sarah; Smith, Leonard A.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Reisler, Ronald B.] MedStar Georgetown Univ Hosp, Clinton, MD 20735 USA. [Gueerena, Fernando] US Army, Ft Drum, NY 13602 USA. RP Pittman, PR (reprint author), US Army, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM phillip.r.pittman.civ@mail.mil FU Defense Threat Reduction Agency, Joint Science and Technology Office for Chemical-Biological Defense FX The authors wish to thank Elizabeth S. Brown, Ph.D., for her editorial contributions to this manuscript. This work was supported by the Defense Threat Reduction Agency, Joint Science and Technology Office for Chemical-Biological Defense. NR 37 TC 4 Z9 5 U1 2 U2 14 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD DEC 16 PY 2015 VL 33 IS 51 BP 7299 EP 7306 DI 10.1016/j.vaccine.2015.10.094 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA CZ0FD UT WOS:000366779600025 PM 26546259 ER PT J AU Chantawansri, TL Yeh, IC Hsieh, AJ AF Chantawansri, Tanya L. Yeh, In-Chul Hsieh, Alex J. TI Investigating the glass transition temperature at the atom-level in select model polyamides: A molecular dynamics study SO POLYMER LA English DT Article DE Polyamide; Molecular dynamics ID METHYLENE CHAIN UNITS; FREE-VOLUME; MICROPHASE SEPARATION; STRUCTURAL RELAXATION; MECHANICAL-PROPERTIES; COMPUTER-SIMULATIONS; THERMAL-ANALYSIS; FORCE-FIELD; CRYSTALLINITY; POLYMERS AB The molecular influence on glass transition temperature (T-g) of select model polyamides was investigated by atomistic modeling. These include nylon 6,6, nylon 6,12, a cycloaliphatic polyamide consisting of 4,4'-methylene-bis(cyclohexylamine) and dodecanedioic acid, as well as a corresponding aromatic counterpart consisting of 4,4'-methylenedianiline and dodecanedioic acid. For each model system, all-atom atomistic molecular dynamics simulations were used to discern and differentiate parameters such as free volume, hydrogen bonding, and chain rigidity. Simulations were able to predict the correct trend in T-g, where the model cycloaliphatic polyamide was shown to have the highest Tg followed by the aromatic polyamide. This is presumably due to the greater chain rigidity exhibited by the cycloaliphatic polyamide around the cyclohexyl ring, which was revealed through a calculation of the dihedral rotation free energy barrier associated with the methylene moiety between either the bis-cyclohexyl or bis-phenyl rings, despite the former having a higher extent of free volume. Published by Elsevier Ltd. C1 [Chantawansri, Tanya L.; Yeh, In-Chul; Hsieh, Alex J.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Chantawansri, TL (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM tanya.chantawansri.civ@mail.mil FU U.S. Army Research Laboratory (ARL) FX This work was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory (ARL) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and ARL. The authors would like to thank Dr. F.T. Willmore for useful discussion and for use of his CESA program and scripts. Calculations were performed using the DOD Supercomputing Resource Center located at the Air Force Laboratory. NR 61 TC 2 Z9 2 U1 7 U2 30 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 EI 1873-2291 J9 POLYMER JI Polymer PD DEC 16 PY 2015 VL 81 BP 50 EP 61 DI 10.1016/j.polymer.2015.09.069 PG 12 WC Polymer Science SC Polymer Science GA CX6LZ UT WOS:000365813800007 ER PT J AU Bruhl, JC Varma, AH Kim, JM AF Bruhl, Jakob C. Varma, Amit H. Kim, Joo Min TI Static resistance function for steel-plate composite (SC) walls subject to impactive loading SO NUCLEAR ENGINEERING AND DESIGN LA English DT Article ID SHEAR CONNECTORS; CONCRETE; DESIGN; PERFORATION; BEHAVIOR; DATABASE; SAFETY AB Steel-plate composite (SC) walls consist of a plain concrete core reinforced with two steel faceplates on the surfaces. Modules (consisting of steel faceplates, shear connectors and tie-bars) can be shop-fabricated and shipped to the site for erection and concrete casting, which expedites construction schedule and thus economy. SC structures have recently been used in nuclear power plant designs and are being considered for the next generation of small modular reactors. Design for impactive and impulsive loading is an important consideration for SC walls in safety-related nuclear facilities. The authors have previously developed design methods to prevent local failure (perforation) of SC walls due to missile impact. This paper presents the development of static resistance functions for use in single-degree-of-freedom (SDOF) analyses to predict the maximum displacement response of SC walls subjected to missile impact and designed to resist local failure (perforation). The static resistance function for SC walls is developed using results of numerical analyses and parametric studies conducted using benchmarked 3D finite element (FE) models. The influence of various design parameters are discussed and used to develop idealized bilinear resistance functions for SC walls with fixed edges and simply supported edges. Results from dynamic non-linear FE analysis of SC panels subjected to rigid missile impact are compared with the maximum displacements predicted by SDOF analyses using the bilinear resistance function. Published by Elsevier B.V. C1 [Bruhl, Jakob C.; Varma, Amit H.; Kim, Joo Min] Purdue Univ, Lyles Sch Civil Engn, W Lafayette, IN 47907 USA. RP Bruhl, JC (reprint author), US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. EM jbruhl@purdue.edu; ahvarma@purdue.edu; kim1493@purdue.edu OI Bruhl, Jakob/0000-0002-1645-4520 NR 35 TC 1 Z9 1 U1 1 U2 4 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0029-5493 EI 1872-759X J9 NUCL ENG DES JI Nucl. Eng. Des. PD DEC 15 PY 2015 VL 295 BP 843 EP 859 DI 10.1016/j.nucengdes.2015.07.037 PG 17 WC Nuclear Science & Technology SC Nuclear Science & Technology GA CZ9JK UT WOS:000367413700079 ER PT J AU Mullins, JC Van Ert, M Hadfield, T Nikolich, MP Hugh-Jones, ME Blackburn, JK AF Mullins, Jocelyn C. Van Ert, Matthew Hadfield, Ted Nikolich, Mikeljon P. Hugh-Jones, Martin E. Blackburn, Jason K. TI Spatio-temporal patterns of an anthrax outbreak in white-tailed deer, Odocoileus virginanus, and associated genetic diversity of Bacillus anthracis SO BMC ECOLOGY LA English DT Article DE Bacillus anthracis; Anthrax; Wildlife; Genetic diversity; Outbreak; Transmission ID WEST TEXAS; SPATIAL-PATTERNS; REPEAT ANALYSIS; NATIONAL-PARK; WILDLIFE; USA; EPIZOOTICS; LIVESTOCK; SOFTWARE; DISEASE AB Background: Anthrax, a soil-borne zoonosis caused by the bacterium Bacillus anthracis, is enzootic in areas of North America with frequent outbreaks in west Texas. Despite a long history of study, pathogen transmission during natural outbreaks remains poorly understood. Here we combined case-level spatio-temporal analysis and high resolution genotyping to investigate anthrax transmission dynamics. Carcass locations from a single white-tailed deer, Odocoileus virginanus, outbreak were analyzed for spatial clustering using K-function analysis and directionality with trend surface analysis and the direction test. Results: The directionalities were compared to results of high resolution genotyping. The results of the spatial clustering analyses, combined with deer movement data, suggest anthrax transmission events occur within limited spatial areas, with carcass locations occurring within the activity space of adjacent cases. The directionality of the outbreak paralleled adjacent dry river beds. Isolates from the outbreak were represented by a single genotype based on multiple locus variable number tandem repeat analysis (MLVA); four sub-genotypes were identified using single nucleotide repeat (SNR) analysis. Conclusions: Areas of high transmission agreed spatially with areas of higher SNR genetic diversity; however, SNRs did not provide clear evidence of linear transmission. Overlap of case home ranges provides spatial and temporal support for localized transmission, which may include the role of necrophagous or hematophagous flies in outbreaks in this region. These results emphasize the need for active surveillance and prompt cleanup of anthrax carcasses to control anthrax both during outbreaks and between seasons. C1 [Mullins, Jocelyn C.; Van Ert, Matthew; Blackburn, Jason K.] Univ Florida, Dept Geog, Spatial Epidemiol & Ecol Res Lab, Gainesville, FL 32611 USA. [Mullins, Jocelyn C.; Van Ert, Matthew; Hadfield, Ted; Blackburn, Jason K.] Univ Florida, Emerging Pathogens Inst, Gainesville, FL 32611 USA. [Nikolich, Mikeljon P.] Walter Reed Army Inst Res, Dept Emerging Bacterial Infect Bacterial Dis Bran, Silver Spring, MD USA. [Hugh-Jones, Martin E.] Louisiana State Univ, Sch Coast & Environm, Dept Environm Sci, Baton Rouge, LA 70803 USA. RP Blackburn, JK (reprint author), Univ Florida, Emerging Pathogens Inst, Gainesville, FL 32611 USA. EM jkblackburn@ufl.edu FU Spatial Epidemiology and Ecology Research Lab; Emerging Pathogens Institute at UF; [NSF-1203557] FX SNR work was sponsored by NSF-1203557 to JKB and JCM. Additional support was provided by the Spatial Epidemiology and Ecology Research Lab and the Emerging Pathogens Institute at UF. DNA from the outbreak were provided to UF by Walter Reed Army Medical Institute of Research. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The findings and opinions expressed herein belong to the authors and do not necessarily reflect the official views of the Walter Reed Army Institute of Research, the U.S. Army or the Department of Defense. NR 47 TC 0 Z9 0 U1 4 U2 13 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1472-6785 J9 BMC ECOL JI BMC Ecol. PD DEC 15 PY 2015 VL 15 AR 23 DI 10.1186/s12898-015-0054-8 PG 11 WC Ecology SC Environmental Sciences & Ecology GA CZ6RZ UT WOS:000367229700001 PM 26669305 ER PT J AU Bright, CJ Nallon, EC Polcha, MP Schnee, VP AF Bright, Collin J. Nallon, Eric C. Polcha, Michael P. Schnee, Vincent P. TI Quantum Dot and Polymer Composite Cross-Reactive Array for Chemical Vapor Detection SO ANALYTICAL CHEMISTRY LA English DT Article ID SENSOR ARRAY; NOSE TECHNOLOGY; ELECTRONIC NOSE; EXPLOSIVES; DISCRIMINATION; PHOTODETECTORS; BREATH; FILMS; LUNG AB A cross-reactive chemical sensing array was made from CdSe Quantum Dots (QDs) and five different organic polymers by inkjet printing to create segmented fluorescent composite regions on quartz substrates. The sensor array was challenged with exposures from two sets of analytes, including one set of 14 different functionalized benzenes and one set of 14 compounds related to security concerns, including the explosives trinitrotoluene (TNT) and ammonium nitrate. The array was broadly responsive to analytes with different chemical functionalities due to the multiple sensing mechanisms that altered the QDs' fluorescence. The sensor array displayed excellent discrimination between members within both sets. Classification accuracy of more than 93% was achieved, including the complete discrimination of very similar dinitrobenzene isomers and three halogenated, substituted benzene compounds. The simple fabrication, broad responsivity, and high discrimination capacity of this type of cross-reactive array are ideal qualities for the development of sensors with excellent sensitivity to chemical and explosive threats while maintaining low false alarm rates. C1 [Bright, Collin J.; Nallon, Eric C.; Polcha, Michael P.; Schnee, Vincent P.] US Army, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA 22060 USA. [Bright, Collin J.] CACI Int Inc Arlington, Arlington, VA 22201 USA. [Polcha, Michael P.] Fulcrum IT Serv, Centerville, VA 20120 USA. RP Schnee, VP (reprint author), US Army, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA 22060 USA. EM vincent.p.schnee.civ@mail.mil NR 41 TC 1 Z9 1 U1 19 U2 68 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 EI 1520-6882 J9 ANAL CHEM JI Anal. Chem. PD DEC 15 PY 2015 VL 87 IS 24 BP 12270 EP 12275 DI 10.1021/acs.analchem.5b03559 PG 6 WC Chemistry, Analytical SC Chemistry GA CZ1NC UT WOS:000366871500045 PM 26548712 ER PT J AU Kaplan, JE Bateganya, MH Hamm, TE Langley, C AF Kaplan, Jonathan E. Bateganya, Moses H. Hamm, Tiffany E. Langley, Carol TI Authors' Reply: Evidence-Based Programming of HIV Care and Support: Is the Psychosocial "Optional"? SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Letter ID CLINICAL-OUTCOMES; INTERVENTIONS; IMPACT; COUNTRIES C1 [Kaplan, Jonathan E.; Bateganya, Moses H.] Ctr Dis Control & Prevent, Div Global HIV AIDS, Atlanta, GA USA. [Hamm, Tiffany E.] Walter Reed Army Inst Res, Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Langley, Carol] US Dept State, Off US Global AIDS Coordinator & Hlth Diplomacy, Washington, DC 20520 USA. RP Kaplan, JE (reprint author), Ctr Dis Control & Prevent, Div Global HIV AIDS, Atlanta, GA USA. NR 11 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD DEC 15 PY 2015 VL 70 IS 5 BP E178 EP E179 DI 10.1097/QAI.0000000000000840 PG 2 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CX3LN UT WOS:000365600400006 PM 26569180 ER PT J AU Sarney, WL Svensson, SP AF Sarney, Wendy L. Svensson, Stefan P. TI Composition modulated InAsSb superlattice induced by non-incorporating Bismuth SO JOURNAL OF CRYSTAL GROWTH LA English DT Article DE Crystal structure; X-ray diffraction; Molecular beam epitaxy; Semiconducting III-V materials ID GROWTH AB We report a new method for synthesizing a composition superlattice with molecular beam epitaxy. A repeated structure of InAs(l-x)Sb(x)/InAs(1-y)Sb(y) was induced by periodic cycling of a non-incorporating Bi-flux, while keeping the In-, As- and Sb-fluxes constant. The Bi acts as a virtual chemical valve. Highresolution X-ray diffraction demonstrated a modulation ratio of x/y=1:1.3. Composition broadening could not be detected within the experimental resolution. The Bi, despite not incorporating, also does not remain on the growing surface after the incoming Bi-flux is terminated. Published by Elsevier B.V. C1 [Sarney, Wendy L.; Svensson, Stefan P.] US Army Res Lab, Adelphi, MD 20783 USA. RP Sarney, WL (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 12 TC 0 Z9 0 U1 3 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0248 EI 1873-5002 J9 J CRYST GROWTH JI J. Cryst. Growth PD DEC 15 PY 2015 VL 432 BP 105 EP 107 DI 10.1016/j.jcrysgro.2015.08.026 PG 3 WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied SC Crystallography; Materials Science; Physics GA CW2JX UT WOS:000364819400017 ER PT J AU Kinzel, EC Ginn, JC Florence, LA Lail, BA Boreman, GD AF Kinzel, Edward C. Ginn, James C. Florence, Louis A. Lail, Brian A. Boreman, Glenn D. TI Directional thermal emission from a leaky-wave frequency-selective surface SO JOURNAL OF NANOPHOTONICS LA English DT Article DE frequency-selective surface; metasurface; thermal emission; infrared antenna; hemispherical directional reflectometer ID ANTENNA; LIGHT; DESIGN; BAND AB We design, fabricate, and characterize a frequency-selective surface (FSS) with directional thermal emission and absorption for long-wave infrared wavelengths. The FSS consists of an array of patch antennas connected by microstrips, the ensemble of which supports leakywave-type modes with forward and backward propagating branches. The branches are designed to intersect at 9.8 mu m and have a broadside beam with 20-deg full width at half maximum at this wavelength. The absorption along these branches is near unity. Measurement of the hemispherical directional reflectometer shows good agreement with simulation. The ability to control the spectral and directional emittance/absorptance profiles of surfaces has significant applications for radiation heat transfer and sensing. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. C1 [Kinzel, Edward C.] Missouri Univ Sci & Technol, Dept Mech & Aerosp Engn, 400 West 13th St, Rolla, MO 65409 USA. [Ginn, James C.] Plasmonics Inc, Orlando, FL 32826 USA. [Florence, Louis A.] US Mil Acad, Phys & Nucl Engn Dept, Ctr Sci, West Point, NY 10996 USA. [Lail, Brian A.] Florida Inst Technol, Elect & Comp Engn, Melbourne, FL 32901 USA. [Boreman, Glenn D.] Univ N Carolina, Phys & Opt Sci, Charlotte, NC 28223 USA. RP Kinzel, EC (reprint author), Missouri Univ Sci & Technol, Dept Mech & Aerosp Engn, 400 West 13th St, Rolla, MO 65409 USA. EM kinzele@mst.edu RI Lail, Brian/L-6382-2015 OI Lail, Brian/0000-0001-6039-3385 NR 20 TC 0 Z9 0 U1 11 U2 18 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 1934-2608 J9 J NANOPHOTONICS JI J. Nanophotonics PD DEC 14 PY 2015 VL 9 AR 093040 DI 10.1117/1.JNP.9.093040 PG 7 WC Nanoscience & Nanotechnology; Optics SC Science & Technology - Other Topics; Optics GA DJ5HW UT WOS:000374238500001 ER PT J AU Wang, CJ Gong, ZY Pan, YL Videen, G AF Wang, Chuji Gong, Zhiyong Pan, Yong-Le Videen, Gorden TI Optical trap-cavity ringdown spectroscopy as a single-aerosol-particle-scope SO APPLIED PHYSICS LETTERS LA English DT Article ID ABSORBING PARTICLES; ATMOSPHERIC AEROSOL; REFRACTIVE-INDEX; RAMAN-SPECTRA; LASER-BEAM; EXTINCTION; AIR; RETRIEVAL; DROPLETS; SIZE AB We report a single-aerosol-particle-scope using an optical trapping-cavity ringdown spectroscopy technique. The scope can not only view physical parameters such as size, motion, and restoring force constant of a single aerosol particle trapped in air but also display time-, particle-, or wavelength-resolved chemical properties such as single aerosol particle extinction. We demonstrate the scope by trapping and walking single carbon-nanotube particles of similar to 50 mu m in size and viewing those properties via changes of ringdown time. This single-aerosol-particle-scope offers a powerful tool to study both physical and chemical properties as well as their evolving dynamics. (C) 2015 AIP Publishing LLC. C1 [Wang, Chuji; Gong, Zhiyong] Mississippi State Univ, Dept Phys & Astron, Starkville, MI 39759 USA. [Pan, Yong-Le; Videen, Gorden] US Army, Res Lab, Adelphi, MD 20783 USA. RP Wang, CJ (reprint author), Mississippi State Univ, Dept Phys & Astron, Starkville, MI 39759 USA. EM cw175@msstate.edu OI Gong, Zhiyong/0000-0002-3004-1589 FU U.S. Army Research Office [W911NF-13-1-0429, W911NF-12-2-0019] FX This research was supported by the U.S. Army Research Office Grant Nos. W911NF-13-1-0429 and W911NF-12-2-0019. NR 34 TC 2 Z9 2 U1 6 U2 19 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD DEC 14 PY 2015 VL 107 IS 24 AR 241903 DI 10.1063/1.4937467 PG 5 WC Physics, Applied SC Physics GA CZ7ZF UT WOS:000367318600019 ER PT J AU Coller, BA Barrett, ADT Thomas, SJ AF Coller, Beth-Ann Barrett, Alan D. T. Thomas, Stephen J. TI SPECIAL ISSUE: Dengue Vaccines Introduction SO VACCINE LA English DT Editorial Material C1 [Coller, Beth-Ann] Merck & Co Inc, Kenilworth, NJ 07033 USA. [Barrett, Alan D. T.] Univ Texas Med Branch, Sealy Ctr Vaccine Dev, Galveston, TX 77555 USA. [Thomas, Stephen J.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Coller, BA (reprint author), Merck & Co Inc, 2000 Galloping Hill Rd, Kenilworth, NJ 07033 USA. EM Beth-ann.coller@merck.com; abarrett@utmb.edu; Stephen.j.thomas3.mil@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD DEC 10 PY 2015 VL 33 IS 50 SI SI BP 7049 EP 7050 PG 2 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA CZ0CA UT WOS:000366771500001 PM 26597033 ER PT J AU Rothman, AL Currier, JR Friberg, HL Mathew, A AF Rothman, Alan L. Currier, Jeffrey R. Friberg, Heather L. Mathew, Anuja TI Analysis of cell-mediated immune responses in support of dengue vaccine development efforts SO VACCINE LA English DT Article DE Dengue; Cell-mediated immunity; Vaccine ID CD8(+) T-CELL; QUALITY-ASSURANCE PROGRAM; VIRUS-INFECTION; HEMORRHAGIC-FEVER; SECONDARY INFECTION; ANTIBODY-RESPONSE; CROSS-REACTIVITY; PROTECTIVE ROLE; FLOW-CYTOMETRY; CLINICAL-TRIAL AB Dengue vaccine development has made significant strides, but a better understanding of how vaccine-induced immune responses correlate with vaccine efficacy can greatly accelerate development, testing, and deployment as well as ameliorate potential risks and safety concerns. Advances in basic immunology knowledge and techniques have already improved our understanding of cell-mediated immunity of natural dengue virus infection and vaccination. We conclude that the evidence base is adequate to argue for inclusion of assessments of cell-mediated immunity as part of clinical trials of dengue vaccines, although further research to identify useful correlates of protective immunity is needed. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Rothman, Alan L.; Mathew, Anuja] Univ Rhode Isl, Inst Immunol & Informat, Providence, RI 02903 USA. [Rothman, Alan L.; Mathew, Anuja] Univ Rhode Isl, Dept Cell & Mol Biol, Providence, RI 02903 USA. [Currier, Jeffrey R.; Friberg, Heather L.] Walter Reed Army Inst Res, Virus Dis Branch, Silver Spring, MD USA. RP Rothman, AL (reprint author), Univ Rhode Isl, Inst Immunol & Informat, 80 Washington St, Providence, RI 02903 USA. EM alan_rothman@uri.edu; jeffrey.r.currier.ctr@mail.mil; heather.l.friberg-robertson.ctr@mail.mil; mathewa@uri.edu OI Rothman, Alan/0000-0002-4064-6848 NR 94 TC 0 Z9 0 U1 3 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD DEC 10 PY 2015 VL 33 IS 50 SI SI BP 7083 EP 7090 DI 10.1016/j.vaccine.2015.09.104 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA CZ0CA UT WOS:000366771500006 PM 26458801 ER PT J AU Cresce, AV Gobet, M Borodin, O Peng, J Russell, SM Wikner, E Fu, A Hu, LB Lee, HS Zhang, ZC Yang, XQ Greenbaum, S Amine, K Xu, K AF Cresce, Arthur von Wald Gobet, Mallory Borodin, Oleg Peng, Jing Russell, Selena M. Wikner, Emily Fu, Adele Hu, Libo Lee, Hung-Sui Zhang, Zhengcheng Yang, Xiao-Qing Greenbaum, Steven Amine, Khalil Xu, Kang TI Anion Solvation in Carbonate-Based Electrolytes SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID HIGHLY ASSOCIATED SALTS; LITHIUM-ION BATTERIES; PROPYLENE CARBONATE; MOLECULAR-DYNAMICS; TRIS(PENTAFLUOROPHENYL) BORANE; STRUCTURAL INTERACTIONS; ORGANIC ELECTROLYTES; GRAPHITIC ANODE; SOLVENT; INTERPHASE AB With the correlation between Li+ solvation and interphasial chemistry on anodes firmly established in Li-ion batteries, the effect of cation-solvent interaction has gone beyond bulk thermodynamic and transport properties and become an essential element that determines the reversibility of electrochemistry and kinetics of Li-ion intercalation chemistries. As of now, most studies are dedicated to the solvation of Li+, and the solvation of anions in carbonate-based electrolytes and its possible effect on the electrochemical stability of such electrolytes remains little understood. As a mirror effort to prior Li+ solvation studies, this work focuses on the interactions between carbonate-based solvents and two anions (hexafluorophosphate, PF6-, and tetrafluoroborate, BF4-) that are most frequently used in Li-ion batteries. The possible correlation between such interaction and the interphasial chemistry on cathode surface is also explored. C1 [Cresce, Arthur von Wald; Borodin, Oleg; Russell, Selena M.; Wikner, Emily; Fu, Adele; Xu, Kang] US Army, Res Lab, Electrochem Branch, Sensors & Electron Devices, Adelphi, MD 20783 USA. [Gobet, Mallory; Peng, Jing; Greenbaum, Steven] CUNY, Dept Phys & Astron, New York, NY 10065 USA. [Peng, Jing] CUNY, Chem Doctorate Program, New York, NY 10065 USA. [Hu, Libo; Zhang, Zhengcheng; Amine, Khalil] Argonne Natl Lab, Chem Sci & Engn Div, Argonne, IL 60439 USA. [Lee, Hung-Sui; Yang, Xiao-Qing] Brookhaven Natl Lab, Dept Chem, Long Isl City, NY 11973 USA. RP Cresce, AV (reprint author), US Army, Res Lab, Electrochem Branch, Sensors & Electron Devices, Adelphi, MD 20783 USA. EM arthur.v.cresce.civ@mail.mil RI Borodin, Oleg/B-6855-2012; Gobet, Mallory/I-2498-2013 OI Borodin, Oleg/0000-0002-9428-5291; Gobet, Mallory/0000-0001-9735-0741 FU US Department of Energy [DE-EE0006543]; American Society for Engineer Education under summer internship at ARL FX This work is partially funded by US Department of Energy under the Interagency Agreement No. DE-EE0006543. Dr. Selena Russell was supported by an appointment to the US Army Research Laboratory (ARL) Fellowship Program administered by the Oak Ridge Associated Universities through a cooperative agreement with ARL. The authors also thank Yue Li from Department of Chemistry at University of Maryland College Park for his assistance with the mass spectrometry experiments. Ms. Emily Wilmer and Ms. Adele Fu were supported by American Society for Engineer Education under summer internship at ARL. NR 49 TC 6 Z9 6 U1 9 U2 55 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD DEC 10 PY 2015 VL 119 IS 49 BP 27255 EP 27264 DI 10.1021/acs.jpcc.5b08895 PG 10 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA CY3VW UT WOS:000366339000009 ER PT J AU Ladner, JT Wiley, MR Mate, S Dudas, G Prieto, K Lovett, S Nagle, ER Beitzel, B Gilbert, ML Fakoli, L Diclaro, JW Schoepp, RJ Fair, J Kuhn, JH Hensley, LE Park, DJ Sabeti, PC Rambaut, A Sanchez-Lockhart, M Bolay, FK Kugelman, JR Palacios, G AF Ladner, Jason T. Wiley, Michael R. Mate, Suzanne Dudas, Gytis Prieto, Karla Lovett, Sean Nagle, Elyse R. Beitzel, Brett Gilbert, Merle L. Fakoli, Lawrence Diclaro, Joseph W., II Schoepp, Randal J. Fair, Joseph Kuhn, Jens H. Hensley, Lisa E. Park, Daniel J. Sabeti, Pardis C. Rambaut, Andrew Sanchez-Lockhart, Mariano Bolay, Fatorma K. Kugelman, Jeffrey R. Palacios, Gustavo TI Evolution and Spread of Ebola Virus in Liberia, 2014-2015 SO CELL HOST & MICROBE LA English DT Article ID RAPID RESPONSE; 2014 OUTBREAK; SIERRA-LEONE; REMOTE AREAS; WEST-AFRICA; TRANSMISSION; EPIDEMIC; GUINEA AB The 2013-present Western African Ebola virus disease (EVD) outbreak is the largest ever recorded with >28,000 reported cases. Ebola virus (EBOV) genome sequencing has played an important role throughout this outbreak; however, relatively few sequences have been determined from patients in Liberia, the second worst-affected country. Here, we report 140 EBOV genome sequences from the second wave of the Liberian outbreak and analyze them in combination with 782 previously published sequences from throughout the Western African outbreak. While multiple early introductions of EBOV to Liberia are evident, the majority of Liberian EVD cases are consistent with a single introduction, followed by spread and diversification within the country. Movement of the virus within Liberia was widespread, and reintroductions from Liberia served as an important source for the continuation of the already ongoing EVD outbreak in Guinea. Overall, little evidence was found for incremental adaptation of EBOV to the human host. C1 [Ladner, Jason T.; Wiley, Michael R.; Mate, Suzanne; Prieto, Karla; Lovett, Sean; Nagle, Elyse R.; Beitzel, Brett; Sanchez-Lockhart, Mariano; Kugelman, Jeffrey R.; Palacios, Gustavo] US Army, Ctr Genome Sci, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Dudas, Gytis; Rambaut, Andrew] Univ Edinburgh, Inst Evolutionary Biol, Ashworth Labs, Edinburgh EH9 3FL, Midlothian, Scotland. [Gilbert, Merle L.] US Army, Mol & Translat Sci Div, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Fakoli, Lawrence; Bolay, Fatorma K.] Liberian Inst Biomed Res, Charlesville, Liberia. [Diclaro, Joseph W., II] Naval Med Res Unit 3, Cairo 11517, Egypt. [Schoepp, Randal J.] US Army, Diagnost Syst Div, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Fair, Joseph] MRI Global, Rockville, MD 20850 USA. [Fair, Joseph] Penn State Univ, Huck Inst Life Sci, University Pk, PA 16802 USA. [Kuhn, Jens H.; Hensley, Lisa E.] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD 21702 USA. [Park, Daniel J.; Sabeti, Pardis C.] Broad Inst, Cambridge, MA 02142 USA. [Sabeti, Pardis C.] Harvard Univ, Cambridge, MA 02138 USA. [Rambaut, Andrew] Univ Edinburgh, Ashworth Labs, Ctr Immunol Infect & Evolut, Edinburgh EH9 3FL, Midlothian, Scotland. [Rambaut, Andrew] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. RP Ladner, JT (reprint author), US Army, Ctr Genome Sci, Med Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA. EM jason.t.ladner.ctr@mail.mil; gustavo.f.palacios.ctr@mail.mil RI Palacios, Gustavo/I-7773-2015; OI Palacios, Gustavo/0000-0001-5062-1938; Dudas, Gytis/0000-0002-0227-4158 FU Defense Threat Reduction Agency; S Agency for International Development; EU [278433-PREDEMICS]; National Institute of Allergy and Infectious Diseases [HHSN272200700016I]; Global Biosurveillance Technology Initiative; Global Emerging Infections System FX This work was supported by the Defense Threat Reduction Agency, Global Biosurveillance Technology Initiative, Global Emerging Infections System and US Agency for International Development. A.R. was supported by EU Seventh Framework Programme (FP7/2007-2013) under Grant Agreement no. 278433-PREDEMICS. The content of this publication does not necessarily reflect the views or policies of the US Army, the US Dept of Defense, the US Dept of Health and Human Services or the institutions/companies affiliated with the authors. J.H.K. performed this work as an employee of Tunnell Government Services, Inc., a subcontractor to Battelle Memorial Institute under its prime contract with the National Institute of Allergy and Infectious Diseases (Contract No. HHSN272200700016I). NR 44 TC 18 Z9 18 U1 4 U2 41 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 1931-3128 EI 1934-6069 J9 CELL HOST MICROBE JI Cell Host Microbe PD DEC 9 PY 2015 VL 18 IS 6 BP 659 EP 669 DI 10.1016/j.chom.2015.11.008 PG 11 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA CY1AL UT WOS:000366138400008 PM 26651942 ER PT J AU Liu, F Kozlovskaya, V Medipelli, S Xue, B Ahmad, F Saeed, M Cropek, D Kharlampieva, E AF Liu, Fei Kozlovskaya, Veronika Medipelli, Srikanth Xue, Bing Ahmad, Fahim Saeed, Mohammad Cropek, Donald Kharlampieva, Eugenia TI Temperature-Sensitive Polymersomes for Controlled Delivery of Anticancer Drugs SO CHEMISTRY OF MATERIALS LA English DT Article ID TRIBLOCK COPOLYMER VESICLES; BLOCK-COPOLYMERS; RAFT POLYMERIZATION; NANOPARTICLES; MICELLES; POLY(N-VINYLCAPROLACTAM); RELEASE; SYSTEM; PH; POLY(N-ISOPROPYLACRYLAMIDE) AB We report on a novel type of triblock copolymer polymersomes with temperature-controlled permeability within the physiologically relevant temperature range of 37-42 degrees C for sustained delivery of anticancer drugs. These polymersomes combine characteristics of liposomes, such as biocompatibility, biodegradability, monodispersity, and stability at room temperature, with tunable size and thermal responsiveness provided by amphiphilic triblock copolymers. The temperature-sensitive poly(N-vinylcaprolactam)(n)-poly(dimethylsiloxane)(65)-poly(N-vinylcaprolactam)(n) (PVCLn-PDMS65-PVCLn) copolymers with n = 10, 15, 19, 29, and 50 and polydispersity indexes less than 1.17 are synthesized by controlled RAFT polymerization. The copolymers are assembled into stable vesicles at room temperature when the ratio of PVCL to the total polymer mass is 0.36 = 950 degrees C). Samples sealed in evacuated tubes did not explode, while if sealed under N-2 the explosive effect was intensified. Thus, explosive behavior was attributed to rapid heating and expansion of gas filling nanoporous space. However, although that condition was necessary for explosive behavior, it was not sufficient. Based on SEM, particle sizes via N-2, sorption, electrical conductivity measurements and mechanical strength data under quasi-static compression, it was concluded that the boundaries between the three types of behavior after ignition were associated with (a) mild sintering (fizzling/explosive boundary at around 500 degrees C); and, (b) melting-like fusion of skeletal nanoparticles (explosive/thermite boundary at around 950 degrees C). Overall, mechanically weaker networks fizzled out; too strong behaved as thermites; networks of intermediate strength exploded. For thermite behavior in particular, other factors may be also at play, such as a combination of reduced porosity, a substoichiometric ambunt of LiClO4 and a slower heat release rate. The latter was supported by TGA data in O-2 and was attributed to a slower rate of oxidation of progressively thicker nanostructures as the H-2-reduction temperature increased. C1 [Leventis, Nicholas; Donthula, Suraj; Mandal, Chandana; Sotiriou-Leventis, Chariklia] Missouri Univ Sci & Technol, Dept Chem, Rolla, MO 65409 USA. [Ding, Michael S.] Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA. RP Leventis, N (reprint author), Missouri Univ Sci & Technol, Dept Chem, Rolla, MO 65409 USA. EM leventis@mst.edu; michael.s.ding.civ@mail.mil; cslevent@mst.edu FU Army Research Office [W911NF-12-2-0029] FX We thank the Army Research Office for financial support under Cooperative Agreement No. W911NF-12-2-0029. We also thank the Materials Research Center of MS&T for support with materials characterization. NR 35 TC 2 Z9 2 U1 2 U2 16 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0897-4756 EI 1520-5002 J9 CHEM MATER JI Chem. Mat. PD DEC 8 PY 2015 VL 27 IS 23 BP 8126 EP 8137 DI 10.1021/acs.chemmater.5b03898 PG 12 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA CY2FC UT WOS:000366223200033 ER PT J AU Christensen, G Younes, H Hong, HP Smith, P AF Christensen, Greg Younes, Hammad Hong, Haiping Smith, Pauline TI Effects of solvent hydrogen bonding, viscosity, and polarity on the dispersion and alignment of nanofluids containing Fe2O3 nanoparticles SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID THERMAL-CONDUCTIVITY ENHANCEMENT; HEAT-TRANSFER; TRANSPORT-PROPERTIES; WATER NANOFLUIDS; ETHYLENE GLYCOL; OXIDE SURFACES; ZNO; SUSPENSIONS; AL2O3; TEMPERATURE AB It has been shown that the alignment of Iron (III) oxide (Fe2O3) nanoparticles in water (H2O) can enhance the thermal conductivity of nanofluids. To better understand solvent effects such as hydrogen bonding, viscosity, and polarity, nanofluids were prepared by mixing Fe2O3 nanoparticles and various solvents (water, ethanol, 1-propanol, isopropanol, 2-propanone, hexane, cyclohexane, ethylene glycol, glycerol, etc.), and the dispersions and alignments of the Fe2O3 nanoparticles in these solvents with and without an applied magnetic field were investigated using an optical microscope. The microscope images indicated that inter-molecule hydrogen bonding of the solvents with one OH group (water, ethanol, 1-propanol, and isopropanol) could help to disperse and align the Fe2O3 nanoparticles. The intra-molecular hydrogen bonding causes a dramatic increase in viscosity for fluids with multiple OH groups, such as ethylene glycol (C2H6O2) and glycerol (C3H8O3), and makes the Fe2O3 nanoparticles dispersion and alignment difficult. Adding water to those fluids could lead to significantly reduced viscosity and make the particles disperse and align well. Polarity studies indicated that higher polarity yields better dispersion and alignment of the Fe2O3 nanoparticles. Thermal studies showed that thermal conductivity of nanofluids containing metal oxide particles with hydrogen bonding in solvents is enhanced compared to the theoretically calculated data. Intermolecular hydrogen bonding between water and ethylene glycol increases the thermal conductivity of nanofluids while decreasing the fluid viscosity. The results also well explain why 50 wt. % water/50 wt. % ethylene glycol is an excellent commercial coolant. Since high thermal conductivity enhancement with minimal viscosity increase is the primary goal of heat transfer nanofluids, this current research may open new doors to better understanding of the fundamental nature of nanofluids. (C) 2015 AIP Publishing LLC. C1 [Christensen, Greg; Younes, Hammad; Hong, Haiping] South Dakota Sch Mines & Technol, Dept Mat & Met Engn, Rapid City, SD 57701 USA. [Smith, Pauline] US Army Res Lab, Aberdeen, MD 21005 USA. RP Hong, HP (reprint author), South Dakota Sch Mines & Technol, Dept Mat & Met Engn, Rapid City, SD 57701 USA. EM haiping.hong@sdsmt.edu FU Army Research Laboratory [W911NF-08-2-0022]; NASA EPSCoR [NNX09AU83A] FX The financial support of Army Research Laboratory_Cooperative Agreement No. W911NF-08-2-0022 and NASA EPSCoR_Award No. NNX09AU83A is acknowledged. NR 45 TC 1 Z9 1 U1 6 U2 10 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD DEC 7 PY 2015 VL 118 IS 21 AR 214302 DI 10.1063/1.4936171 PG 9 WC Physics, Applied SC Physics GA DD4UK UT WOS:000369918100018 ER PT J AU DeCoste, JB Rossin, JA Peterson, GW AF DeCoste, Jared B. Rossin, Joseph A. Peterson, Gregory W. TI Hierarchical Pore Development by Plasma Etching of Zr-Based Metal-Organic Frameworks SO CHEMISTRY-A EUROPEAN JOURNAL LA English DT Article DE hierarchical porosity; mesoporous materials; metal-organic frameworks; plasma etching; UiO-66 ID POSTSYNTHETIC LIGAND; ROOM-TEMPERATURE; BUILDING UNIT; ADSORPTION; ZIRCONIUM; STABILITY; FUNCTIONALIZATION; DESTRUCTION; DEPOSITION; CATALYSIS AB The typically stable Zr-based metal-organic frameworks (MOFs) UiO-66 and UiO-66-NH2 were treated with tetrafluoromethane (CF4) and hexafluoroethane (C2F6) plasmas. Through interactions between fluoride radicals from the perfluoroalkane plasma and the zirconium-oxygen bonds of the MOF, the resulting materials showed the development of mesoporosity, creating a hierarchical pore structure. It is anticipated that this strategy can be used as a post-synthetic technique for developing hierarchical networks in a variety of MOFs. C1 [Peterson, Gregory W.] US Army, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 20101 USA. [DeCoste, Jared B.] Leidos Inc, Gunpowder, MD 21010 USA. [Rossin, Joseph A.] Guild Associates Inc, Dublin, OH 43228 USA. RP Peterson, GW (reprint author), US Army, Edgewood Chem Biol Ctr, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 20101 USA. EM gregory.w.peterson.civ@mail.mil FU Defense Threat Reduction Agency (DTRA) [BA07PRO104] FX G.W.P gratefully acknowledge the Defense Threat Reduction Agency (DTRA) for financial support under BA07PRO104. The authors thank the Walton Group at The Georgia Institute of Technology and David Britt at Lawrence Berkeley National Laboratory for providing UiO-66 and UiO-66-NH2, respectively. The authors also thank Shirmonda Smith and Bryan Schindler for collecting nitrogen-isotherm data, George Wagner, and Morgan Hall for collecting NMR data, and Erica Valdes for collecting EDS images. NR 39 TC 2 Z9 2 U1 18 U2 57 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 0947-6539 EI 1521-3765 J9 CHEM-EUR J JI Chem.-Eur. J. PD DEC 7 PY 2015 VL 21 IS 50 BP 18029 EP 18032 DI 10.1002/chem.201503632 PG 4 WC Chemistry, Multidisciplinary SC Chemistry GA CZ6BL UT WOS:000367186000003 PM 26443007 ER PT J AU Lee, AK Kulcsar, KA Elliott, O Khiabanian, H Nagle, ER Jones, MEB Amman, BR Sanchez-Lockhart, M Towner, JS Palacios, G Rabadan, R AF Lee, Albert K. Kulcsar, Kirsten A. Elliott, Oliver Khiabanian, Hossein Nagle, Elyse R. Jones, Megan E. B. Amman, Brian R. Sanchez-Lockhart, Mariano Towner, Jonathan S. Palacios, Gustavo Rabadan, Raul TI De novo transcriptome reconstruction and annotation of the Egyptian rousette bat SO BMC GENOMICS LA English DT Article DE RNA-seq; Transcriptome; Genomics; Annotation; Database ID RNA-SEQ DATA; BLACK FLYING FOX; FRUIT BATS; MARBURG VIRUS; EBOLA-VIRUS; NIPAH VIRUS; EXPERIMENTAL INOCULATION; PTEROPUS-POLIOCEPHALUS; EQUINE MORBILLIVIRUS; REFERENCE GENOME AB Background: The Egyptian Rousette bat (Rousettus aegyptiacus), a common fruit bat species found throughout Africa and the Middle East, was recently identified as a natural reservoir host of Marburg virus. With Ebola virus, Marburg virus is a member of the family Filoviridae that causes severe hemorrhagic fever disease in humans and nonhuman primates, but results in little to no pathological consequences in bats. Understanding host-pathogen interactions within reservoir host species and how it differs from hosts that experience severe disease is an important aspect of evaluating viral pathogenesis and developing novel therapeutics and methods of prevention. Results: Progress in studying bat reservoir host responses to virus infection is hampered by the lack of host-specific reagents required for immunological studies. In order to establish a basis for the design of reagents, we sequenced, assembled, and annotated the R. aegyptiacus transcriptome. We performed de novo transcriptome assembly using deep RNA sequencing data from 11 distinct tissues from one male and one female bat. We observed high similarity between this transcriptome and those available from other bat species. Gene expression analysis demonstrated clustering of expression profiles by tissue, where we also identified enrichment of tissue-specific gene ontology terms. In addition, we identified and experimentally validated the expression of novel coding transcripts that may be specific to this species. Conclusion: We comprehensively characterized the R. aegyptiacus transcriptome de novo. This transcriptome will be an important resource for understanding bat immunology, physiology, disease pathogenesis, and virus transmission. C1 [Lee, Albert K.; Rabadan, Raul] Columbia Univ Coll Phys & Surg, Dept Biomed Informat, New York, NY 10032 USA. [Lee, Albert K.; Elliott, Oliver; Khiabanian, Hossein; Rabadan, Raul] Columbia Univ Coll Phys & Surg, Dept Syst Biol, New York, NY 10032 USA. [Kulcsar, Kirsten A.; Nagle, Elyse R.; Sanchez-Lockhart, Mariano; Palacios, Gustavo] US Army, Med Res Inst Infect Dis, Ctr Genome Sci, Ft Detrick, MD 21702 USA. [Jones, Megan E. B.; Amman, Brian R.; Towner, Jonathan S.] Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Atlanta, GA 30333 USA. [Palacios, Gustavo] George Mason Univ, Natl Ctr Biodef & Infect Dis, Manassas, VA 20110 USA. RP Rabadan, R (reprint author), Columbia Univ Coll Phys & Surg, Dept Biomed Informat, New York, NY 10032 USA. EM rr2579@cumc.columbia.edu RI Palacios, Gustavo/I-7773-2015; OI Palacios, Gustavo/0000-0001-5062-1938; Khiabanian, Hossein/0000-0003-1446-4394 FU Defense Threat Reduction Agency (DTRA) [HDTRA1-14-1-0016]; training program in computational biology [5T32GM082797-07] FX We thank Thomas Kepler, Stephanie D'Souza, Adam Hume, Elke Muhlberger, Jenna Kelly for comments and discussion on the project. We also thank Ahhyun Kim for the illustration of a bat in Fig 1a. This work was funded by the Defense Threat Reduction Agency (DTRA) grant HDTRA1-14-1-0016 and the training program in computational biology 5T32GM082797-07. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention or the U.S. Army. NR 50 TC 2 Z9 2 U1 4 U2 23 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2164 J9 BMC GENOMICS JI BMC Genomics PD DEC 7 PY 2015 VL 16 AR 1033 DI 10.1186/s12864-015-2124-x PG 11 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA CX6XI UT WOS:000365844600002 PM 26643810 ER PT J AU Rosenberg, YJ Adams, RJ Hernandez-Abanto, S Jiang, XM Sun, W Mao, LJ Lee, KD AF Rosenberg, Yvonne J. Adams, Robert J. Hernandez-Abanto, Segundo Jiang, Xiaoming Sun, Wei Mao, Lingjun Lee, K. David TI Pharmacokinetics and immunogenicity of a recombinant human butyrylcholinesterase bioscavenger in macaques following intravenous and pulmonary delivery SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article DE Human butyrylcholinesterase; Pharmacokinetics; Immunogenicity; Aerosol delivery; Monkey model; Animal Rule ID HUMAN SERUM BUTYRYLCHOLINESTERASE; N-GLYCOLYLNEURAMINIC ACID; PROTECTION; TOXICITY; ACETYLCHOLINESTERASE; MODEL; SOMAN; PRETREATMENT; STABILITY; PRODUCTS AB Recombinant (r) and native butyrylcholinesterse (BChE) are potent bioscavengers of organophosphates (OPs) such as nerve agents and pesticides and are undergoing development as antidotal treatments for OP-induced toxicity. Because of the lethal properties of such agents, regulatory approval will require extensive testing under the Animal Rule. However, human (Hu) glycoprotein biologicals, such as BChE, present a challenge for assessing immunogenicity and efficacy in heterologous animal models since any immune responses to the small species differences in amino acids or glycans between the host and biologic may alter pharmacodynamics and preclude accurate efficacy testing; possibly underestimating their potential protective value in humans. To establish accurate pharmacokinetic and efficacy data, an homologous animal model has been developed in which native and PEGylated forms of CHO-derived rMaBChE were multiply injected into homologous macaques with no induction of antibody. These now serve as controls for assessing the pharmacokinetics and immunogenicity in macaques of multiple administrations of PEGylated and unmodified human rBChE (rHuBChE) by both intravenous (IV) and pulmonary routes. The results indicate that, except for maximal concentration (Cmax), the pharmacokinetic parameters following IV injection with heterologous PEG-rHuBChE were greatly reduced even after the first injection compared with homologous PEG-rMaBChE. Anti-HuBChE antibody responses were induced in all monkeys after the second and third administrations regardless of the route of delivery; impacting rates of clearance and usually resulting in reduced endogenous MaBChE activity. These data highlight the difficulties inherent in assessing pharmacokinetics and immunogenicity in animal models, but bode well for the efficacy and safety of rHuBChE pretreatments in homologous humans. (C) 2015 Elsevier Ireland Ltd. All rights reserved. C1 [Rosenberg, Yvonne J.; Hernandez-Abanto, Segundo; Jiang, Xiaoming; Mao, Lingjun; Lee, K. David] PlantVax Inc, Rockville, MD 20850 USA. [Adams, Robert J.] Johns Hopkins Univ, Sch Med, Dept Mol & Comparat Pathobiol, Baltimore, MD 21205 USA. [Sun, Wei] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. RP Rosenberg, YJ (reprint author), PlantVax Inc, Rockville, MD 20850 USA. EM yjr@plantvax.com FU National Institutes of Health [U44 NS064608]; National Institute of Neurological Diseases and Stroke (NINDS) grants [U44NS064608]; Defense Threat Reduction Agency [HDTRA1-07-C-0023] FX This work was supported in part by the National Institutes of Health (U44 NS064608), National Institute of Neurological Diseases and Stroke (NINDS) grants #U44NS064608 and the Defense Threat Reduction Agency (#HDTRA1-07-C-0023). NR 31 TC 1 Z9 1 U1 2 U2 3 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 EI 1872-7786 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD DEC 5 PY 2015 VL 242 BP 219 EP 226 DI 10.1016/j.cbi.2015.09.021 PG 8 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA CZ7JI UT WOS:000367275300023 PM 26415620 ER PT J AU Omar, MY Xiang, CC Gupta, N Strbik, OM Cho, K AF Omar, Mohammed Yaseer Xiang, Chongchen Gupta, Nikhil Strbik, Oliver M., III Cho, Kyu TI Syntactic foam core metal matrix sandwich composite under bending conditions SO MATERIALS & DESIGN LA English DT Article DE Metal matrix composite; Sandwich composite; Syntactic foam; Flexural properties ID MINIMUM WEIGHT DESIGN; LOW-VELOCITY IMPACT; TENSILE-STRENGTH; STRAIN-RATES; BEAMS; COLLAPSE; FAILURE; PERFORMANCE; PANELS; DAMAGE AB The present work aims at characterizing a metal matrix syntactic foam core sandwich composite under three-point bending conditions. The sandwich comprises alumina hollow particle reinforced A356 alloy syntactic foam with carbon fabric skins. Crack initiation in the tensile side of the specimen causing failure of the skin, followed by rapid failure of the core in the direction applied load, is observed as the failure mechanism. Crack propagation through the alumina particles is observed in the failed specimens instead of interfacial failure. The average maximum strength, flexural strain and stiffness were measured as 91.2 +/- 5.6 MPa, 0.49 +/- 0.06% and 20.6 +/- 0.7 GPa respectively. The collapse load is theoretically predicted using mechanics of sandwich beams. Experimental values show good agreement with theoretical predictions. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Omar, Mohammed Yaseer; Xiang, Chongchen; Gupta, Nikhil] NYU, Polytech Sch Engn, Mech & Aerosp Engn Dept, Composite Mat & Mech Lab,MetroTech Ctr 6, Brooklyn, NY 11201 USA. [Strbik, Oliver M., III] Deep Springs Technol Inc, Toledo, OH 43615 USA. [Cho, Kyu] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Gupta, N (reprint author), NYU, Polytech Sch Engn, Mech & Aerosp Engn Dept, Composite Mat & Mech Lab,MetroTech Ctr 6, Brooklyn, NY 11201 USA. EM ngupta@nyu.edu OI gupta, nikhil/0000-0001-7128-4459 FU U.S. Army Research Laboratory contract of DST [W911NF-10-2-0084, W911NF-11-2-0096]; NYU; NSF [IIA-445686]; NYUAD Vice Chancellor's office FX This research is sponsored by the U.S. Army Research Laboratory contract W911NF-10-2-0084 of DST and the Cooperative Agreement W911NF-11-2-0096 with NYU. Partial support from NSF grant IIA-445686 is also acknowledged. The authors acknowledge scholarship from the NYUAD Vice Chancellor's office to Mohammed. Dr. Dung Dinh Luong and Steven E. Zeltmann are thanked for their help during the research work. NR 50 TC 4 Z9 4 U1 4 U2 24 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-1275 EI 1873-4197 J9 MATER DESIGN JI Mater. Des. PD DEC 5 PY 2015 VL 86 BP 536 EP 544 DI 10.1016/j.matdes.2015.07.127 PG 9 WC Materials Science, Multidisciplinary SC Materials Science GA CT5PO UT WOS:000362862700067 ER PT J AU Kumar, N Ying, Q Nie, X Mishra, RS Tang, Z Liaw, PK Brennan, RE Doherty, KJ Cho, KC AF Kumar, N. Ying, Q. Nie, X. Mishra, R. S. Tang, Z. Liaw, P. K. Brennan, R. E. Doherty, K. J. Cho, K. C. TI High strain-rate compressive deformation behavior of the Al0.1CrFeCoNi high entropy alloy SO MATERIALS & DESIGN LA English DT Article DE High entropy alloy; High strain-rate deformation; Twinning; Work hardening; Mechanical property; Split Hopkinson pressure bar ID MECHANICAL-PROPERTIES; PLASTIC-DEFORMATION; TENSILE PROPERTIES; STAINLESS-STEEL; MICROSTRUCTURE; EVOLUTION; SYSTEM; PHASE; AL0.1COCRFENI; STABILITY AB High entropy alloy is a new class of structural metallic materials. No work, so far, has been carried-out to understand high strain-rate plastic deformation behavior and resulting microstructure. This work focuses on understanding the deformation behavior of an Al0.1CrFeCoNi HEA at high strain-rate (HSR). HSR plastic deformation in compression mode was carried out using split-Hopkinson pressure bar. The pre- and post-deformation microstructures were studied using electron microscopes. A high strain-rate sensitivity of yield strength, significant work hardening, and profuse twinning are main characteristics observed during deformation of the alloy at HSR. Overall, the deformation behavior of the alloy was consistent with low stacking fault energy materials. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Kumar, N.; Mishra, R. S.] Univ N Texas, Dept Mat Sci & Engn, Ctr Frict Stir Proc, Denton, TX 76203 USA. [Ying, Q.; Nie, X.] Univ N Texas, Dept Mech & Energy Engn, Denton, TX 76203 USA. [Tang, Z.; Liaw, P. K.] Univ Tennessee, Dept Mat Sci & Engn, Knoxville, TN 37996 USA. [Brennan, R. E.; Doherty, K. J.; Cho, K. C.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Mishra, RS (reprint author), Univ N Texas, Dept Mat Sci & Engn, Ctr Frict Stir Proc, Denton, TX 76203 USA. EM Rajiv.Mishra@unt.edu RI Mishra, Rajiv/A-7985-2009 OI Mishra, Rajiv/0000-0002-1699-0614 FU Army Research Laboratory [W911NF-13-2-0018]; University of North Texas [W911NF-13-2-0018] FX The work was performed under a cooperative agreement between the Army Research Laboratory and the University of North Texas (W911NF-13-2-0018). The authors are also thankful to the Center for Advanced Research and Technology (CART) for providing access to the microscopy facilities at the University of North Texas. NR 34 TC 11 Z9 11 U1 13 U2 87 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-1275 EI 1873-4197 J9 MATER DESIGN JI Mater. Des. PD DEC 5 PY 2015 VL 86 BP 598 EP 602 DI 10.1016/j.matdes.2015.07.161 PG 5 WC Materials Science, Multidisciplinary SC Materials Science GA CT5PO UT WOS:000362862700074 ER PT J AU Meledeo, MA Rodriguez, AC Voelker, CR Bynum, JA Cap, AP AF Meledeo, Michael Adam Rodriguez, Armando C. Voelker, Chet R. Bynum, James A. Cap, Andrew P. TI In Vitro Assessment of Altered Thrombin-Fibrinogen Interaction As a Mechanism for Acute Traumatic Coagulopathy SO BLOOD LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Hematology CY DEC 05-08, 2015 CL Orlando, FL SP Amer Soc Hematol C1 [Meledeo, Michael Adam; Rodriguez, Armando C.; Voelker, Chet R.; Bynum, James A.] US Army, Inst Surg Res, San Antonio, TX USA. [Cap, Andrew P.] US Army Inst Surg Res, Coagulat & Blood Res, Jbsa Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA SN 0006-4971 EI 1528-0020 J9 BLOOD JI Blood PD DEC 3 PY 2015 VL 126 IS 23 PG 4 WC Hematology SC Hematology GA DA7XN UT WOS:000368019003199 ER PT J AU Nair, PM Dallo, S Cap, AP Ramasubramanian, AK AF Nair, Prajeeda M. Dallo, Shatha Cap, Andrew P. Ramasubramanian, Anand K. TI Cold-Stored Platelets in PAS Exhibit Superior Hemostatic Potential SO BLOOD LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Hematology CY DEC 05-08, 2015 CL Orlando, FL SP Amer Soc Hematol C1 [Nair, Prajeeda M.] Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX USA. [Nair, Prajeeda M.] Univ Texas Hlth Sci Ctr San Antonio, Dept Biomed Engn, San Antonio, TX 78229 USA. [Dallo, Shatha] Univ Texas San Antonio, San Antonio, TX USA. [Cap, Andrew P.] US Army Inst Surg Res, Coagulat & Blood Res, Jbsa Ft Sam Houston, TX USA. [Ramasubramanian, Anand K.] Univ Texas San Antonio, Biomed Engn, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA SN 0006-4971 EI 1528-0020 J9 BLOOD JI Blood PD DEC 3 PY 2015 VL 126 IS 23 PG 3 WC Hematology SC Hematology GA DA7XN UT WOS:000368019002209 ER PT J AU Salzer, W Burke, MJ Larsen, EC Chen, S Gore, L Hilden, JM Loh, ML Raetz, E Winick, NJ Carroll, WL Devidas, M Hunger, SP AF Salzer, Wanda Burke, Michael J. Larsen, Eric C. Chen, Si Gore, Lia Hilden, Joanne M. Loh, Mignon L. Raetz, Elizabeth Winick, Naomi J. Carroll, William L. Devidas, Meenakshi Hunger, Stephen P. TI Incidence of Allergic Reactions to Pegaspargase (PEG) Administered Intramuscularly Versus Intravenously (IM vs. IV) in Children and Young Adults with High Risk B-Lymphoblastic Leukemia (HR B-ALL): Results of Children's Oncology Group (COG) Studies AALL0232/AALL1131 SO BLOOD LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Hematology CY DEC 05-08, 2015 CL Orlando, FL SP Amer Soc Hematol C1 [Salzer, Wanda] US Army Med Res & Mat Command, Ft Detrick, MD USA. [Burke, Michael J.] Med Coll Wisconsin, Div Hematol Oncol Bone Marrow Transplantat, Milwaukee, WI 53226 USA. [Burke, Michael J.] Childrens Hosp Wisconsin, Milwaukee, WI 53201 USA. [Larsen, Eric C.] Maine Childrens Canc Program, Scarborough, ME USA. [Chen, Si; Devidas, Meenakshi] Univ Florida, Coll Med, Dept Biostat, Gainesville, FL USA. [Chen, Si; Devidas, Meenakshi] Univ Florida, Coll Publ Hlth, Dept Biostat, Gainesville, FL USA. [Chen, Si; Devidas, Meenakshi] Univ Florida, Coll Hlth Profess, Dept Biostat, Gainesville, FL USA. [Gore, Lia; Hilden, Joanne M.] Childrens Hosp Colorado, Ctr Canc & Blood Disorders, Aurora, CO USA. [Gore, Lia; Hilden, Joanne M.] Univ Colorado, Sch Med, Aurora, CO USA. [Loh, Mignon L.] Univ Calif San Francisco, Dept Pediat, Benioff Childrens Hosp, San Francisco, CA 94143 USA. [Raetz, Elizabeth] Univ Utah, Dept Pediat, Huntsman Canc Inst, Salt Lake City, UT USA. [Raetz, Elizabeth] Univ Utah, Primary Childrens Hosp, Salt Lake City, UT USA. [Winick, Naomi J.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA. [Carroll, William L.] NYU, Med Ctr, Dept Pediat, Perlmutter Canc Ctr, New York, NY 10016 USA. [Hunger, Stephen P.] Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA. [Hunger, Stephen P.] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA SN 0006-4971 EI 1528-0020 J9 BLOOD JI Blood PD DEC 3 PY 2015 VL 126 IS 23 PG 3 WC Hematology SC Hematology GA DA7XN UT WOS:000368019004103 ER PT J AU Bynum, JA Chance, T Meledeo, MA Pidcoke, HF AF Bynum, James A. Chance, Tiffani Meledeo, Michael Adam Pidcoke, Heather F. TI Gene Expression Profiling Reveals Key Mitochondrial Gene Changes in Stored Platelets SO BLOOD LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Hematology CY DEC 05-08, 2015 CL Orlando, FL SP Amer Soc Hematol C1 [Bynum, James A.; Meledeo, Michael Adam; Pidcoke, Heather F.] US Army, Inst Surg Res, San Antonio, TX USA. [Chance, Tiffani] Johns Hopkins Univ, Baltimore, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA SN 0006-4971 EI 1528-0020 J9 BLOOD JI Blood PD DEC 3 PY 2015 VL 126 IS 23 PG 3 WC Hematology SC Hematology GA DA7XY UT WOS:000368020105125 ER PT J AU Henderson, AT Mitchell, TA Cap, AP Herzig, MC Fedyk, CG AF Henderson, Aaron T. Mitchell, Thomas A. Cap, Andrew P. Herzig, Maryanne C. Fedyk, Chriselda G. TI Autotransfusion of Hemothorax Blood Is Prothrombotic but Inhibits Platelet Aggregation: A Potentiator of Disseminated Intravascular Coagulation SO BLOOD LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Hematology CY DEC 05-08, 2015 CL Orlando, FL SP Amer Soc Hematol C1 [Henderson, Aaron T.] San Antonio Mil Med Ctr, Hematol & Oncol, Ft Sam Houston, TX USA. [Mitchell, Thomas A.] San Antonio Mil Med Ctr, Gen Surg, San Antonio, TX USA. [Cap, Andrew P.; Herzig, Maryanne C.; Fedyk, Chriselda G.] US Army Inst Surg Res, Coagulat & Blood Res, Jbsa Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA SN 0006-4971 EI 1528-0020 J9 BLOOD JI Blood PD DEC 3 PY 2015 VL 126 IS 23 PG 3 WC Hematology SC Hematology GA DA7XY UT WOS:000368020101183 ER PT J AU Rabin, KR Hitzler, J Rodriguez, V Schore, R Angiolillo, A Burke, MJ Salzer, W Maloney, K Lu, XM Devidas, M Loh, ML Raetz, E Hunger, SP AF Rabin, Karen R. Hitzler, Johann Rodriguez, Vilmarie Schore, Reuven Angiolillo, Anne Burke, Michael J. Salzer, Wanda Maloney, Kelly Lu, Xiaomin Devidas, Meenakshi Loh, Mignon L. Raetz, Elizabeth Hunger, Stephen P. TI Treatment-Related Mortality (TRM) in Children with Down Syndrome (DS) and B-Lymphoblastic Leukemia (B-ALL): An Interim Report from the Children's Oncology Group Trials AALL0932 and AALL1131 SO BLOOD LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Hematology CY DEC 05-08, 2015 CL Orlando, FL SP Amer Soc Hematol C1 [Rabin, Karen R.] Baylor Coll Med, Hematol Oncol, Pediat, Houston, TX 77030 USA. [Hitzler, Johann] Hosp Sick Children, Dept Pediat, Div Hematol Oncol, Toronto, ON M5G 1X8, Canada. [Rodriguez, Vilmarie] Mayo Clin, Div Pediat Hematol & Oncol, Rochester, MN USA. [Schore, Reuven; Angiolillo, Anne] Childrens Natl Med Ctr, Washington, DC 20010 USA. [Burke, Michael J.] Med Coll Wisconsin, Div Hematol Oncol Bone Marrow Transplantat, Milwaukee, WI 53226 USA. [Burke, Michael J.] Childrens Hosp Wisconsin, Milwaukee, WI 53201 USA. [Salzer, Wanda] US Army Med Res & Mat Command, Ft Detrick, MD USA. [Maloney, Kelly] Childrens Hosp Colorado, Aurora, CO USA. [Lu, Xiaomin] Univ Florida, Dept Biostat, Gainesville, FL USA. [Devidas, Meenakshi] Univ Florida, Coll Med, Dept Biostat, Gainesville, FL USA. [Devidas, Meenakshi] Univ Florida, Coll Publ Hlth, Dept Biostat, Gainesville, FL USA. [Devidas, Meenakshi] Univ Florida, Coll Hlth Profess, Dept Biostat, Gainesville, FL USA. [Loh, Mignon L.] Univ Calif San Francisco, Dept Pediat, Benioff Childrens Hosp, San Francisco, CA USA. [Raetz, Elizabeth] Univ Utah, Dept Pediat, Huntsman Canc Inst, Salt Lake City, UT USA. [Raetz, Elizabeth] Univ Utah, Primary Childrens Hosp, Salt Lake City, UT USA. [Hunger, Stephen P.] Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA. [Hunger, Stephen P.] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA SN 0006-4971 EI 1528-0020 J9 BLOOD JI Blood PD DEC 3 PY 2015 VL 126 IS 23 PG 3 WC Hematology SC Hematology GA DA7XY UT WOS:000368020102014 ER PT J AU Shaha, JS El-Othmani, MM Saleh, JK Bozic, KJ Wright, J Tokish, JM Shaha, SH Saleh, KJ AF Shaha, James S. El-Othmani, Mouhanad M. Saleh, Jamal K. Bozic, Kevin J. Wright, James Tokish, John M. Shaha, Steve H. Saleh, Khaled J. TI The Growing Gap in Electronic Medical Record Satisfaction Between Clinicians and Information Technology Professionals Issues of Most Concern and Suggested Remediations SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME LA English DT Article ID PHYSICIAN ORDER ENTRY; HEALTH RECORDS; PRIMARY-CARE; PATIENT; SYSTEM; IMPACT; IMPLEMENTATION; INTERVENTION; PREVENTION; HOSPITALS AB Background: With the alarming statistics concerning the quality of national health care, it is hoped that electronic health records (EHRs) will reduce inefficiencies associated with medical delivery and improve patient safety. This study reports the results of a survey that demonstrates a pattern in EHR system implementation that indicates that healthcare information technology decisions are based more on the preferences of information technology professionals (ITPs) and hospital administrators than clinicians. Methods: We present survey data highlighting the growing discrepancy in EHR-related satisfaction between clinicians and ITPs. We conducted a literature search to identify major barriers that must be overcome to achieve optimal EHR benefits. We summarize our recommendations in order to maximize the favorable impact of EHRs on the health-care system. Results: The existing gap in postimplementation EHR satisfaction ratings between ITPs and clinicians reveals an underlying systematic problem. Electronic medical record vendors perceive administrators and ITPs as the "buyers" for many EHR systems, and their needs are given higher priority than those of clinicians. This possibly may lead to the lack of clinically optimized EHRs, with systems often presenting as rigid and standardized with a limited exchange of health information. Conclusions: EHRs have the potential to become a powerful tool that may improve many processes related to health care, including quality, safety, and economical aspects. The involvement of physicians in every step of the process, from electronic medical record selection to acquisition, implementation, and ongoing optimization, is crucial for enabling the achievement of the medical organization's mission. C1 [Shaha, James S.; El-Othmani, Mouhanad M.; Saleh, Jamal K.; Bozic, Kevin J.; Wright, James; Tokish, John M.; Shaha, Steve H.; Saleh, Khaled J.] Tripler Army Med Ctr, Dept Orthopaed Surg, Honolulu, HI 96859 USA. RP Shaha, JS (reprint author), Tripler Army Med Ctr, Dept Orthopaed Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM ksaleh@siumed.edu OI El-Othmani, Mouhanad/0000-0001-7211-4072 NR 32 TC 1 Z9 1 U1 7 U2 12 PU JOURNAL BONE JOINT SURGERY INC PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02192 USA SN 0021-9355 EI 1535-1386 J9 J BONE JOINT SURG AM JI J. Bone Joint Surg.-Am. Vol. PD DEC 2 PY 2015 VL 97A IS 23 BP 1979 EP 1984 DI 10.2106/JBJS.N.01118 PG 6 WC Orthopedics; Surgery SC Orthopedics; Surgery GA CY4TM UT WOS:000366401300014 PM 26632000 ER PT J AU Poly, F Serichantalergs, O Kuroiwa, J Pootong, P Mason, C Guerry, P Parker, CT AF Poly, Frederic Serichantalergs, Oralak Kuroiwa, Janelle Pootong, Piyarat Mason, Carl Guerry, Patricia Parker, Craig T. TI Updated Campylobacter jejuni Capsule PCR Multiplex Typing System and Its Application to Clinical Isolates from South and Southeast Asia SO PLOS ONE LA English DT Article ID POLYSACCHARIDE CONJUGATE VACCINE; IRRITABLE-BOWEL-SYNDROME; GENOME SEQUENCE; DIVERSITY; SEROTYPE; IDENTIFICATION; OUTBREAK; CHILDREN; THAILAND; STRAIN AB Campylobacter jejuni produces a polysaccharide capsule that is the major determinant of the Penner serotyping scheme. This passive slide agglutination typing system was developed in the early 1980's and was recognized for over two decades as the gold standard for C. jejuni typing. A preliminary multiplex PCR technique covering 17 serotypes was previously developed in order to replace this classic serotyping scheme. Here we report the completion of the multiplex PCR technology that is able to identify all the 47 Penner serotypes types known for C. jejuni. The number of capsule types represented within the 47 serotypes is 35. We have applied this method to a collection of 996 clinical isolates from Thailand, Cambodia and Nepal and were able to successfully determine capsule types of 98% of these. C1 [Poly, Frederic; Kuroiwa, Janelle; Guerry, Patricia] Naval Med Res Ctr, Enter Dis Dept, Silver Spring, MD 20910 USA. [Serichantalergs, Oralak; Pootong, Piyarat; Mason, Carl] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Parker, Craig T.] ARS, USDA, Albany, CA USA. RP Poly, F (reprint author), Naval Med Res Ctr, Enter Dis Dept, Silver Spring, MD 20910 USA. EM frederic.m.poly.ctr@mail.mil OI MASON, CARL/0000-0002-3676-2811 FU U.S. Naval Medical Research and Development Command Work Unit [6000.RAD1.DA3.A0308]; US department of agriculture-Agricultural Research Service [CRIS 5325-42000-047]; Military Infectious Diseases Research Program, Walter Reed Army Institute of Research, Washington, DC FX This work was supported by U.S. Naval Medical Research and Development Command Work Unit 6000.RAD1.DA3.A0308 (FP JK PP PG). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. US department of agriculture-Agricultural Research Service, CRIS 5325-42000-047 (CTP). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Military Infectious Diseases Research Program, Walter Reed Army Institute of Research, Washington, DC (OS PP CM). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 45 TC 2 Z9 2 U1 0 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 2 PY 2015 VL 10 IS 12 AR e0144349 DI 10.1371/journal.pone.0144349 PG 17 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CX8BI UT WOS:000365926300181 PM 26630669 ER PT J AU Gong, C Ruzmetov, D Pearse, A Ma, DK Munday, JN Rubloff, G Talin, AA Leite, MS AF Gong, Chen Ruzmetov, Dmitry Pearse, Alexander Ma, Dakang Munday, Jeremy N. Rubloff, Gary Talin, A. Alec Leite, Marina S. TI Surface/Interface Effects on High-Performance Thin-Film All-Solid-State Li-Ion Batteries SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE energy storage; all-solid-state batteries; thin-films; aluminum; silicon ID TRANSMISSION ELECTRON-MICROSCOPY; ELECTROCHEMICAL PERFORMANCE; LITHIUM BATTERIES; ANODES; SILICON; LITHIATION; STABILITY; OXIDATION; ALUMINUM; CARBON AB The further development of all-solid-state batteries is still limited by the understanding/engineering of the interfaces formed upon cycling. Here, we correlate the morphological, chemical, and electrical changes of the surface of thin-film devices with Al negative electrodes. The stable Al-Li-O alloy formed at the stress-free surface of the electrode causes rapid capacity fade, from 48.0 to 41.5 mu Ah/cm(2) in two cycles. Surprisingly, the addition of a Cu capping layer is insufficient to prevent the device degradation. Nevertheless, Si electrodes present extremely stable cycling, maintaining >92% of its capacity after 100 cycles, with average Coulombic efficiency of 98%. C1 [Gong, Chen; Leite, Marina S.] Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA. [Gong, Chen; Pearse, Alexander; Ma, Dakang; Munday, Jeremy N.; Rubloff, Gary; Leite, Marina S.] Univ Maryland, Inst Res Elect & Appl Phys, College Pk, MD 20742 USA. [Ma, Dakang; Munday, Jeremy N.] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. [Rubloff, Gary] Univ Maryland, Syst Res Inst, College Pk, MD 20742 USA. [Ruzmetov, Dmitry] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Ruzmetov, Dmitry] NIST, Mat Measurement Lab, Gaithersburg, MD 20899 USA. [Talin, A. Alec] Sandia Natl Labs, Livermore, CA 94550 USA. RP Leite, MS (reprint author), Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA. EM aatalin@sandia.gov; mleite@umd.edu RI Munday, Jeremy/E-6512-2016; Gong, Chen/R-9309-2016; Pearse, Alexander/B-2792-2017 OI Munday, Jeremy/0000-0002-0881-9876; Gong, Chen/0000-0003-3302-7675; FU School of Engineering at the University of Maryland; Minta Martin Award; Laboratory Directed Research and Development Program at Sandia National Laboratories; U.S. DOE National Nuclear Security Administration [DE-AC04-94AL85000]; U.S. Department of Energy, Office of Science, and Office of Basic Energy Sciences [DESC0001160] FX MSL and JNM thank the financial support from the School of Engineering at the University of Maryland, and the Minta Martin Award. CG acknowledge the University of Maryland 2015 Graduate School's Summer Research Fellowship program. This work was partially supported by the Laboratory Directed Research and Development Program at Sandia National Laboratories. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the U.S. DOE National Nuclear Security Administration under Contract DE-AC04-94AL85000. Nanostructures for Electrical Energy Storage (NEES), an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, and Office of Basic Energy Sciences under award DESC0001160, provided partial support to AAT and GR for data analysis and manuscript authoring, and to AP for carrying out XPS experiments and analysis. NR 30 TC 4 Z9 4 U1 19 U2 121 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD DEC 2 PY 2015 VL 7 IS 47 BP 26007 EP 26011 DI 10.1021/acsami.5b07058 PG 5 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA CX8DB UT WOS:000365931700001 PM 26436529 ER PT J AU Chaorattanakawee, S Lanteri, CA Sundrakes, S Yingyuen, K Gosi, P Chanarat, N Wongarunkochakorn, S Buathong, N Chann, S Kuntawunginn, W Arsanok, M Lin, JT Juliano, JJ Tyner, SD Char, M Lon, C Saunders, DL AF Chaorattanakawee, Suwanna Lanteri, Charlotte A. Sundrakes, Siratchana Yingyuen, Kritsanai Gosi, Panita Chanarat, Nitima Wongarunkochakorn, Saowaluk Buathong, Nillawan Chann, Soklyda Kuntawunginn, Worachet Arsanok, Montri Lin, Jessica T. Juliano, Jonathan J. Tyner, Stuart D. Char, Mengchuor Lon, Chanthap Saunders, David L. TI Attenuation of Plasmodium falciparum in vitro drug resistance phenotype following culture adaptation compared to fresh clinical isolates in Cambodia SO MALARIA JOURNAL LA English DT Article DE Malaria; In vitro drug susceptibility; Culture adaptation; Cambodia ID POPULATION-DYNAMICS; MALARIA PARASITES; SENSITIVITY; ASSAY; SUSCEPTIBILITY; ARTEMISININ; INVITRO; WESTERN; INFECTIONS; MUTATIONS AB Background: There is currently no standardized approach for assessing in vitro anti-malarial drug susceptibility. Potential alterations in drug susceptibility results between fresh immediate ex vivo (IEV) and cryopreserved culture-adapted (CCA) Plasmodium falciparum isolates, as well as changes in parasite genotype during culture adaptation were investigated. Methods: The 50 % inhibitory concentration (IC50) of 12 P. falciparum isolates from Cambodia against a panel of commonly used drugs were compared using both IEV and CCA. Results were compared using both histidine-rich protein-2 ELISA (HRP-2) and SYBR-Green I fluorescence methods. Molecular genotyping and amplicon deep sequencing were also used to compare multiplicity of infection and genetic polymophisms in fresh versus culture-adapted isolates. Results: IC50 for culture-adapted specimens were significantly lower compared to the original fresh isolates for both HRP-2 and SYBR-Green I assays, with greater than a 50 % decline for the majority of drug-assay combinations. There were correlations between IC(50)s from IEV and CCA for most drugs assays. Infections were nearly all monoclonal, with little or no change in merozoite surface protein 1 (MSP1), MSP2, glutamate-rich protein (GLURP) or apical membrane antigen 1 (AMA1) polymorphisms, nor differences in P. falciparum multidrug resistance 1 gene (PfMDR1) copy number or single nucleotide polymorphisms following culture adaptation. Conclusions: The overall IC50 reduction combined with the correlation between fresh isolates and culture-adapted drug susceptibility assays suggests the utility of both approaches, as long as there is consistency of method, and remaining mindful of possible attenuation of resistance phenotype occurring in culture. Further study should be done in higher transmission settings where polyclonal infections are prevalent. C1 [Chaorattanakawee, Suwanna; Lanteri, Charlotte A.; Sundrakes, Siratchana; Yingyuen, Kritsanai; Gosi, Panita; Chanarat, Nitima; Wongarunkochakorn, Saowaluk; Buathong, Nillawan; Chann, Soklyda; Kuntawunginn, Worachet; Arsanok, Montri; Tyner, Stuart D.; Lon, Chanthap; Saunders, David L.] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. [Lin, Jessica T.; Juliano, Jonathan J.] Univ N Carolina, Sch Med, Div Infect Dis, Chapel Hill, NC USA. [Char, Mengchuor] Natl Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia. RP Lon, C (reprint author), Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. EM ChanthapL@afrims.org FU Global Emerging Infections Surveillance (GEIS) Program, US Department of Defense FX We are grateful to the AFRIMS and Cambodian clinical and laboratory field teams for conducting microscopy and their technical support. We thank Mr. William Ellis at the Walter Reed Army Institute of Research (WRAIR) for providing us with test drugs. This work was funded by the Global Emerging Infections Surveillance (GEIS) Program, US Department of Defense. NR 33 TC 2 Z9 2 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD DEC 2 PY 2015 VL 14 AR 486 DI 10.1186/s12936-015-1021-8 PG 7 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA CX6FE UT WOS:000365795800001 PM 26626127 ER PT J AU Ma, R Ferris, JB Reid, AA Gorsich, DJ AF Ma, Rui Ferris, John B. Reid, Alexander A. Gorsich, David J. TI A planar quasi-static constraint mode tyre model SO VEHICLE SYSTEM DYNAMICS LA English DT Article DE terrain surface; road surface; tyre force estimation; planar tyre model; constraint mode ID SYSTEMS; FORCES AB The fast-paced, iterative, vehicle design environment demands efficiency when simulating suspension loads. Towards that end, a computationally efficient, linear, planar, quasi-static tyre model is developed in this work that accurately predicts a tyre's lower frequency, reasonably large amplitude, nonlinear stiffness relationship. The axisymmetric, circumferentially isotropic, stiffness equation is discretised into segments, then parameterised by a single stiffness parameter and two shape parameters. The tyre's deformed shape is independent of the overall tyre stiffness and the forces acting on the tyre. Constraint modes capture enveloping and bridging properties and a recursive method yields the set of active constraints at the tyre-road interface. The nonlinear stiffness of a tyre is captured by enforcing unidirectional geometric boundary conditions. The model parameters are identified semi-empirically; simulated cleat test loads match experiments within 7% including nonlinear stiffness when simulating a flat plate test and a discontinuous stiffness when simulating a cleat test. C1 [Ma, Rui; Ferris, John B.] Virginia Tech, Dept Mech Engn, Blacksburg, VA 24061 USA. [Reid, Alexander A.; Gorsich, David J.] US Army Tank Automot Res, Dev & Engn Ctr TARDEC, Warren, MI USA. RP Ferris, JB (reprint author), Virginia Tech, Dept Mech Engn, Blacksburg, VA 24061 USA. EM jbferris@vt.edu FU Automotive Research Center (ARC), a U.S. Army Center of Excellence FX This work was supported by the Automotive Research Center (ARC), a U.S. Army Center of Excellence in modelling and simulation of ground vehicles. NR 14 TC 0 Z9 0 U1 1 U2 5 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0042-3114 EI 1744-5159 J9 VEHICLE SYST DYN JI Veh. Syst. Dyn. PD DEC 2 PY 2015 VL 53 IS 12 BP 1759 EP 1771 DI 10.1080/00423114.2015.1088161 PG 13 WC Engineering, Mechanical SC Engineering GA CX4ZO UT WOS:000365709800005 ER PT J AU Burkhard, P Lanar, DE AF Burkhard, Peter Lanar, David E. TI Malaria vaccine based on self-assembling protein nanoparticles SO EXPERT REVIEW OF VACCINES LA English DT Editorial Material DE malaria; nanoparticle; Plasmodium falciparum; SAPN; vaccine ID PEPTIDE NANOPARTICLES; FALCIPARUM-MALARIA; PHASE-3 TRIAL; PROTECTION; CHILDREN; PLATFORM; DISPLAY; DESIGN AB Despite recent progress with GSK's RTS,S malaria vaccine, there remains a desperate need for an efficient malaria vaccine. We have used a repetitive antigen display technology to display malaria specific B cell and T cell epitopes in an effort to design a vaccine against Plasmodium falciparum malaria. Our protein sequence when assembled into a nanoparticle induces strong, long-lived and protective immune responses against infection with the parasite. We are confident that the clinical trials with our most developed vaccine candidate will show good protection in a controlled human malaria infection trial. C1 [Burkhard, Peter] Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA. [Burkhard, Peter] Univ Connecticut, Dept Mol & Cell Biol, Storrs, CT 06269 USA. [Lanar, David E.] Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD 20910 USA. RP Burkhard, P (reprint author), Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA. EM peter.burkhard@uconn.edu FU NIAID NIH HHS [5R01AI068761, R01 AI068761] NR 20 TC 5 Z9 5 U1 2 U2 16 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1476-0584 EI 1744-8395 J9 EXPERT REV VACCINES JI Expert Rev. Vaccines PD DEC 2 PY 2015 VL 14 IS 12 BP 1525 EP 1527 DI 10.1586/14760584.2015.1096781 PG 3 WC Immunology SC Immunology GA CV7XW UT WOS:000364491500001 PM 26468608 ER PT J AU Popham, DL Bernhards, CB AF Popham, David L. Bernhards, Casey B. TI Spore Peptidoglycan SO MICROBIOLOGY SPECTRUM LA English DT Article ID CORTEX-LYTIC ENZYME; CLOSTRIDIUM-PERFRINGENS S40; PENICILLIN-BINDING PROTEIN; BACILLUS-SUBTILIS SPORES; WALL HYDROLASE GENE; NUCLEOTIDE-SEQUENCE; HEAT-RESISTANCE; BACTERIAL-SPORES; MOLECULAR CHARACTERIZATION; STRUCTURAL-ANALYSIS AB Bacterial endospores possess multiple integument layers, one of which is the cortex peptidoglycan wall. The cortex is essential for the maintenance of spore core dehydration and dormancy and contains structural modifications that differentiate it from vegetative cell peptidoglycan and determine its fate during spore germination. Following the engulfment stage of sporulation, the cortex is synthesized within the intermembrane space surrounding the forespore. Proteins responsible for cortex synthesis are produced in both the forespore and mother cell compartments. While some of these proteins also contribute to vegetative cell wall synthesis, others are sporulation specific. In order for the bacterial endospore to germinate and resume metabolism, the cortex peptidoglycan must first be degraded through the action of germination-specific lytic enzymes. These enzymes are present, yet inactive, in the dormant spore and recognize the muramic-delta-lactam modification present in the cortex. Germination-specific lytic enzymes across Bacillaceae and Clostridiaceae share this specificity determinant, which ensures that the spore cortex is hydrolyzed while the vegetative cell wall remains unharmed. Bacillus species tend to possess two redundant enzymes, SleB and CwlJ, capable of sufficient cortex degradation, while the clostridia have only one, SleC. Additional enzymes are often present that cannot initiate the cortex degradation process, but which can increase the rate of release of small fragments into the medium. Between the two families, the enzymes also differ in the enzymatic activities they possess and the mechanisms acting to restrict their activation until germination has been initiated. C1 [Popham, David L.] Virginia Tech, Dept Biol Sci, Life Sci 1, Blacksburg, VA 24061 USA. [Bernhards, Casey B.] US Army, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Popham, DL (reprint author), Virginia Tech, Dept Biol Sci, Life Sci 1, Blacksburg, VA 24061 USA. EM dpopham@vt.edu OI Popham, David/0000-0002-2614-143X NR 138 TC 1 Z9 1 U1 2 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA EI 2165-0497 J9 MICROBIOL SPECTR JI Microbiol. Spectr. PD DEC PY 2015 VL 3 IS 6 AR UNSP TBS-0005-2012 DI 10.1128/microbiolspec.TBS-0005-2012 PG 20 WC Microbiology SC Microbiology GA DT9FD UT WOS:000381800300009 ER PT J AU Koppenhaver, SL Walker, MJ Su, J McGowen, JM Umlauf, L Harris, KD Ross, MD AF Koppenhaver, Shane L. Walker, Michael J. Su, Jonathan McGowen, Jared M. Umlauf, Lindsey Harris, Kevin D. Ross, Michael D. TI Changes in lumbar multifidus muscle function and nociceptive sensitivity in low back pain patient responders versus non-responders after dry needling treatment SO MANUAL THERAPY LA English DT Article DE Acupuncture; Low back pain; Muscle contraction; Ultrasonography ID MYOFASCIAL TRIGGER POINT; NECK PAIN; TRANSVERSUS ABDOMINIS; SPINAL MANIPULATION; PRESSURE ALGOMETRY; CLINICAL-TRIAL; IRRITABILITY; ACUPUNCTURE; RELIABILITY; MANAGEMENT AB Background: Little is known about the physiologic mechanism of dry needling. While some evidence suggests that dry needling may decrease nocioceptive sensitivity and facilitate muscle function, no studies to date have examined these physiologic changes compared to clinical outcomes. Objective: To examine changes in lumbar multifidus (LM) muscle function and nociceptive sensitivity after dry needling in patients with LBP and to determine if such changes differ in patients that exhibit improved disability (responders) and those that do not (non-responders). Design: Quasi-experimental study. Methods: Sixty-six volunteers with mechanical LBP (38 men, age = 41.3 +/- 9.2 years) completed the study. Ultrasound measurements and pain algometry of the LM were taken at baseline and repeated immediately following dry needling treatment to the LM muscles and after one week. The percent change in muscle thickness from rest to contraction was calculated for each time point to represent muscle function. Pressure pain threshold (PPT) was used to measure nociceptive sensitivity. Participants were dichotomized as responders and non-responders based on whether or not they experienced clinical improvement using the modified Oswestry Disability Index after one week. 2 x 3 mixed-model ANOVA were conducted for group (responders vs. non-responders) by time. Results: Patient responders exhibited larger improvements in LM muscle contraction and nociceptive sensitivity 1 week, but not immediately, after dry needling than non-responders. Conclusions: Our results suggest that there may be lasting and clinically relevant sensorimotor changes that occur in LBP patients that improve with dry needling treatment that partially explain the physiologic mechanism of action. Published by Elsevier Ltd. C1 [Koppenhaver, Shane L.; Walker, Michael J.; Su, Jonathan; McGowen, Jared M.; Umlauf, Lindsey] US Army Baylor Univ, Doctoral Program Phys Therapy, San Antonio, TX USA. [Harris, Kevin D.] Guthrie Ambulatory Hlth Clin, Dept Rehabil, Ft Drum, NY USA. [Ross, Michael D.] Univ Scranton, Dept Phys Therapy, Scranton, PA 18510 USA. RP Koppenhaver, SL (reprint author), US Army Baylor Univ, Doctoral Program Phys Therapy, San Antonio, TX USA. EM shanekoppenhaver@mac.com NR 43 TC 1 Z9 1 U1 2 U2 7 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1356-689X EI 1532-2769 J9 MANUAL THER JI Man. Ther. PD DEC PY 2015 VL 20 IS 6 BP 769 EP 776 DI 10.1016/j.math.2015.03.003 PG 8 WC Rehabilitation SC Rehabilitation GA DG6LP UT WOS:000372196300013 PM 25801100 ER PT J AU Hoover, JJ Katzenmeyer, AW Collins, J Lewis, BR Slack, WT George, SG AF Hoover, Jan Jeffrey Katzenmeyer, Alan W. Collins, Jay Lewis, Bradley R. Slack, W. Todd George, Steven G. TI Age and Reproductive Condition of an Unusually Large Bighead Carp from the Lower Mississippi River Basin SO SOUTHEASTERN NATURALIST LA English DT Article ID MISSOURI RIVER; SILVER CARP; HYPOPHTHALMICHTHYS-NOBILIS; ASIAN CARP; GROWTH AB On 24 February 2014, commercial fishers caught an unusually large Hypophthalmichthys nobilis (Bighead Carp) from an oxbow lake in northwestern Mississippi. We examined it to determine age, gonadal development, and fecundity. The specimen was 1316 mm total length, 49.7 kg, and 11 years old. It had asymmetric ovaries that collectively represented 15.7% of the body weight, with an estimated 1.9 to 2.7 million eggs, similar to 40% of which were mature. The data we collected for size, age, and fecundity were all at or near maximum values known for the species. This specimen demonstrates that for life-history studies and demographic models to be representative of introduced populations, rare or hard-to-catch large specimens are required due to their influence on estimates of longevity, mortality, and fecundity. C1 [Hoover, Jan Jeffrey; Katzenmeyer, Alan W.; Collins, Jay; Lewis, Bradley R.; Slack, W. Todd; George, Steven G.] US Army Engineer Res & Dev Ctr, EE A, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. RP Hoover, JJ (reprint author), US Army Engineer Res & Dev Ctr, EE A, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Jan.J.Hoover@usace.army.mil FU Aquatic Nuisance Species Research Program FX The Mississippi Department of Wildlife Fisheries and Parks invited us to participate in fieldwork and provided assistance; Garry Lucas (retired) and Larry Pugh (chief) provided data on Paddlefish populations. James P. Parker and Walter Ray collected the Bighead Carp and brought it to us. Glenn Parsons and Bryan Cage assisted in the field. The Aquatic Nuisance Species Research Program provides funds for our Asian Carp research. The Chief of Engineers approved this paper for publication. Our thanks to all of the people and agencies mentioned above. NR 19 TC 0 Z9 0 U1 13 U2 15 PU HUMBOLDT FIELD RESEARCH INST PI STEUBEN PA PO BOX 9, STEUBEN, ME 04680-0009 USA SN 1528-7092 EI 1938-5412 J9 SOUTHEAST NAT JI Southeast. Nat. PD DEC PY 2015 VL 14 IS 4 BP N55 EP N60 DI 10.1656/058.014.0411 PG 6 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA DE8NL UT WOS:000370892600017 ER PT J AU Zubko, E Videen, G Hines, DC Shkuratov, Y Kaydash, V Muinonen, K Knight, MM Sitko, ML Lisse, CM Mutchler, M Wooden, DH Li, JY Kobayashi, H AF Zubko, Evgenij Videen, Gorden Hines, Dean C. Shkuratov, Yuriy Kaydash, Vadym Muinonen, Karri Knight, Matthew M. Sitko, Michael L. Lisse, Carey M. Mutchler, Max Wooden, Diane H. Li, Jian-Yang Kobayashi, Hiroshi TI Cornet C/2012 S1 (ISON) coma composition at similar to 4 au from HST observations SO PLANETARY AND SPACE SCIENCE LA English DT Article ID O1 HALE-BOPP; HUBBLE-SPACE-TELESCOPE; OPTICAL-CONSTANTS; COMETARY DUST; IMAGING POLARIMETRY; SILICATE MINERALOGY; REFRACTIVE-INDEXES; INFRARED-SPECTRA; LIGHT-SCATTERING; 81P/WILD-2 DUST AB We analyze the first color and polarization images of Comet ISON (C/2012 S1) taken during two measurement campaigns of the Hubble Space Telescope (HST) on UTC 2013 April 10 and May 8, when the phase angles of Comet ISON were alpha approximate to 13.7 degrees and 12.2 degrees, respectively. We model the particles in the coma using highly irregular agglomerated debris particles. Even though the observations were made over a small range of phase angle, the data still place significant constraints on the material properties of the cometary coma. The different photo-polarimetric responses are indicative of spatial chemical heterogeneity of coma in Comet ISON. For instance, at small projected distances to the nucleus (< 500 km), our modeling suggests the cometary particles are composed predominantly of small, highly absorbing particles, such as amorphous carbon and/or organics material heavily irradiated with UV radiation; whereas, at longer projected distances (> 1000 km), the refractive index of the particles is consistent with organic matter slightly processed with UV radiation, tholins, Mg-Fe silicates, and/or Mg-rich silicates contaminated with similar to 10% (by volume) amorphous carbon. The modeling suggests low relative abundances of particles with low material absorption in the visible, i.e., Im(m) <= 0.02. Such particles were detected unambiguously in other comets in the vicinity of nucleus through very strong negative polarization near backscattering (P approximate to -6%) and very low positive polarization (P approximate to 3-5%) at side scattering. These materials were previously attributed to Mg-rich silicates forming a refractory surface layer on the surface of cometary nuclei (Zubko et al., 2012). The absence of such particles in Comet ISON could imply an absence of such a layer on its nucleus. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Zubko, Evgenij; Shkuratov, Yuriy; Kaydash, Vadym] Kharkov Natl Univ, Inst Astron, 35 Sumskaya St, UA-61022 Kharkov, Ukraine. [Videen, Gorden; Hines, Dean C.; Sitko, Michael L.] Space Sci Inst, Boulder, CO 80301 USA. [Videen, Gorden; Mutchler, Max] INTA, Madrid 28850, Spain. [Videen, Gorden] Univ Cantabria, Fac Ciencias, Dept Fis Aplicada, Grp Opt, E-39005 Santander, Spain. [Videen, Gorden] US Army Res Lab, Adelphi, MD 20783 USA. [Hines, Dean C.] Space Telescope Sci Inst, Baltimore, MD 21218 USA. [Muinonen, Karri] Univ Helsinki, Dept Phys, FIN-00014 Helsinki, Finland. [Muinonen, Karri] Finnish Geospatial Res Inst, FI-02431 Masala, Finland. [Knight, Matthew M.] Lowell Observ, Flagstaff, AZ 86001 USA. [Knight, Matthew M.; Lisse, Carey M.] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD 20723 USA. [Sitko, Michael L.] Univ Cincinnati, Dept Phys, Cincinnati, OH 45221 USA. [Wooden, Diane H.] NASA Ames Res Ctr, Mountain View, CA USA. [Li, Jian-Yang] Planetary Sci Inst, Tucson, AZ 85719 USA. [Kobayashi, Hiroshi] Nagoya Univ, Chikusa Ku, Nagoya, Aichi 4648602, Japan. RP Zubko, E (reprint author), Kharkov Natl Univ, Inst Astron, 35 Sumskaya St, UA-61022 Kharkov, Ukraine. EM evgenij.s.zubko@gmail.com RI Lisse, Carey/B-7772-2016; OI Lisse, Carey/0000-0002-9548-1526; Zubko, Evgenij/0000-0001-9994-923X FU NASA from Space Telescope Science Institute [GO 13199]; NASA [NAS5-26555] FX This work was partially supported through program number GO 13199 provided by NASA through a grant from the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS5-26555. NR 86 TC 4 Z9 4 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0032-0633 J9 PLANET SPACE SCI JI Planet Space Sci. PD DEC 1 PY 2015 VL 118 SI SI BP 138 EP 163 DI 10.1016/j.pss.2015.08.002 PG 26 WC Astronomy & Astrophysics SC Astronomy & Astrophysics GA DE2LZ UT WOS:000370460100018 ER PT J AU Lovely, A Loose, B Schlosser, P McGillis, W Zappa, C Perovich, D Brown, S Morell, T Hsueh, D Friedrich, R AF Lovely, A. Loose, B. Schlosser, P. McGillis, W. Zappa, C. Perovich, D. Brown, S. Morell, T. Hsueh, D. Friedrich, R. TI The Gas Transfer through Polar Sea ice experiment: Insights into the rates and pathways that determine geochemical fluxes SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article DE polar ocean; sea ice; gas exchange; carbon cycle; climate change; Arctic ID EXCHANGE; WATER; DIFFUSION; CO2; SOLUBILITY; SEAWATER; OCEAN; COEFFICIENTS; PERCOLATION; ANTARCTICA AB Sea ice is a defining feature of the polar marine environment. It is a critical domain for marine biota and it regulates ocean-atmosphere exchange, including the exchange of greenhouse gases such as CO2 and CH4. In this study, we determined the rates and pathways that govern gas transport through a mixed sea ice cover. N2O, SF6, He-3, He-4, and Ne were used as gas tracers of the exchange processes that take place at the ice-water and air-water interfaces in a laboratory sea ice experiment. Observation of the changes in gas concentrations during freezing revealed that He is indeed more soluble in ice than in water; Ne is less soluble in ice, and the larger gases (N2O and SF6) are mostly excluded during the freezing process. Model estimates of gas diffusion through ice were calibrated using measurements of bulk gas content in ice cores, yielding gas transfer velocity through ice (k(ice)) of approximate to 5 x 10(-4) m d(-1). In comparison, the effective air-sea gas transfer velocities (k(eff)) ranged up to 0.33 m d(-1) providing further evidence that very little mixed-layer ventilation takes place via gas diffusion through columnar sea ice. However, this ventilation is distinct from air-ice gas fluxes driven by sea ice biogeochemistry. The magnitude of k(eff) showed a clear increasing trend with wind speed and current velocity beneath the ice, as well as the combination of the two. This result indicates that gas transfer cannot be uniquely predicted by wind speed alone in the presence of sea ice. C1 [Lovely, A.; Loose, B.] Univ Rhode Isl, Grad Sch Oceanog, Narragansett, RI 02882 USA. [Schlosser, P.; Zappa, C.] Columbia Univ, Dept Earth & Environm Sci, Palisades, NY USA. [Schlosser, P.; McGillis, W.] Columbia Univ, Dept Earth & Environm Engn, New York, NY USA. [Schlosser, P.; McGillis, W.; Zappa, C.; Brown, S.; Morell, T.; Hsueh, D.] Columbia Univ, Lamont Doherty Geol Observ, Palisades, NY 10964 USA. [Perovich, D.] US Army Corps Engineers Cold Reg Res & Engn Lab, Hanover, NH USA. [Friedrich, R.] Heidelberg Univ, Inst Environm Phys, Heidelberg, Germany. RP Loose, B (reprint author), Univ Rhode Isl, Grad Sch Oceanog, Narragansett, RI 02882 USA. EM brice@gso.uri.edu FU Foundation of the University of Rhode Island; Tabor Academy; NSF [ANT 09-44643] FX The authors thank Leonard Zabilansky, Thomas Tantillo, Gordon Gooch, and the rest of the amazing engineering staff at CRREL. We thank Dennis Graham at URI GSO for analyzing samples for DIC and alkalinity. Support for A. Lovely was provided by the Foundation of the University of Rhode Island and by Tabor Academy. Funding support for GAPS and for B. Loose, P. Schlosser, C. J. Zappa, W. R. McGillis, and D. Perovich was provided by NSF ANT 09-44643. Given the nature of this data as laboratory based, we have opted not to submit to an oceanographic repository but all the data have been archived and are available by contacting Brice Loose (brice@gso.uri.edu). NR 44 TC 2 Z9 2 U1 3 U2 15 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-9275 EI 2169-9291 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD DEC PY 2015 VL 120 IS 12 BP 8177 EP 8194 DI 10.1002/2014JC010607 PG 18 WC Oceanography SC Oceanography GA DC3XO UT WOS:000369153200025 ER PT J AU Abbott, JH Chapple, CM Fitzgerald, GK Fritz, JM Childs, JD Harcombe, H Stout, K AF Abbott, J. Haxby Chapple, Catherine M. Fitzgerald, G. Kelley Fritz, Julie M. Childs, John D. Harcombe, Helen Stout, Kirsten TI The Incremental Effects of Manual Therapy or Booster Sessions in Addition to Exercise Therapy for Knee Osteoarthritis: A Randomized Clinical Trial SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE arthralgia; OA; physical therapy techniques; randomized controlled trial ID PHYSICAL-THERAPY; FUNCTIONAL SCALE; HOME EXERCISE; HIP; PHYSIOTHERAPY; PEOPLE; GUIDELINES; MANAGEMENT; CRITERIA; PAIN AB STUDY DESIGN: A factorial randomized controlled trial. OBJECTIVES: To investigate the addition of manual therapy to exercise therapy for the reduction of pain and increase of physical function in people with knee osteoarthritis (OA), and whether "booster sessions" compared to consecutive sessions may improve outcomes. BACKGROUND: The benefits of providing manual therapy in addition to exercise therapy, or of distributing treatment sessions over time using periodic booster sessions, in people with knee OA are not well established. METHODS: All participants had knee OA and were provided 12 sessions of multimodal exercise therapy supervised by a physical therapist. Participants were randomly allocated to 1 of 4 groups: exercise therapy in consecutive sessions, exercise therapy distributed over a year using booster sessions, exercise therapy plus manual therapy without booster sessions, and exercise therapy plus manual therapy with booster sessions. The primary outcome measure was the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC score; 0-240 scale) at 1-year follow-up. Secondary outcome measures were the numeric pain-rating scale and physical performance tests. RESULTS: Of 75 participants recruited, 66 (88%) were retained at 1-year follow-up. Factorial analysis of covariance of the main effects showed significant benefit from booster sessions (P =.009) and manual therapy (P =.023) over exercise therapy alone. Group analysis showed that exercise therapy with booster sessions (WOMAC score, -46.0 points; 95% confidence interval [CI]: -80.0, -12.0) and exercise therapy plus manual therapy (WOMAC score, -37.5 points; 95% CI: -69.7, -5.5) had superior effects compared with exercise therapy alone. The combined strategy of exercise therapy plus manual therapy with booster sessions was not superior to exercise therapy alone. CONCLUSION: Distributing 12 sessions of exercise therapy over a year in the form of booster sessions was more effective than providing 12 consecutive exercise therapy sessions. Providing manual therapy in addition to exercise therapy improved treatment effectiveness compared to providing 12 consecutive exercise therapy sessions alone. Trial registered with the Australian New Zealand Clinical Trials Registry (ACTRN12612000460808). C1 [Abbott, J. Haxby; Harcombe, Helen; Stout, Kirsten] Univ Otago, Dunedin Sch Med, Ctr Musculoskeletal Outcomes Res, Orthopaed Surg Sect,Dept Surg Sci, Dunedin, New Zealand. [Chapple, Catherine M.] Univ Otago, Sch Physiotherapy, Dunedin, New Zealand. [Fitzgerald, G. Kelley] Univ Pittsburgh, Pittsburgh, PA USA. [Fritz, Julie M.] Univ Utah, Salt Lake City, UT USA. [Childs, John D.] US Army Baylor Univ, Schertz, TX USA. [Harcombe, Helen] Univ Otago, Dept Prevent & Social Med, Dunedin, New Zealand. RP Abbott, JH (reprint author), Univ Otago, Dunedin Sch Med, Dept Surg Sci, Ctr Musculoskeletal Outcomes Res, POB 913, Dunedin, New Zealand. EM haxby.abbott@otago.ac.nz OI Abbott, J. Haxby/0000-0001-6468-7284; Chapple, Cathy/0000-0001-5141-8376 FU New Zealand Lottery Grants Board; New Zealand Society of Physiotherapists Scholarship Trust; Health Research Council of New Zealand; University of Otago Research Grant; Sir Charles Hercus Health Research Fellowship from the Health Research Council of New Zealand FX The study protocol was approved by the Lower South Regional Ethics Committee of the New Zealand Ministry of Health (LSR/10/11/055), and registered with the Australian New Zealand Clinical Trials Registry (ACTRN12612000460808). This research was supported in part by the New Zealand Lottery Grants Board, the New Zealand Society of Physiotherapists Scholarship Trust, the Health Research Council of New Zealand, and a University of Otago Research Grant. Dr Abbott was supported in part by a Sir Charles Hercus Health Research Fellowship from the Health Research Council of New Zealand. The funders have had no influence on the content of that work or the current article. The authors certify that they have no affiliations with or financial involvement in any organization or entity with a direct financial interest in the subject matter or materials discussed in the article. NR 33 TC 6 Z9 6 U1 4 U2 10 PU J O S P T PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 EI 1938-1344 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD DEC PY 2015 VL 45 IS 12 BP 975 EP 983 DI 10.2519/jospt.2015.6015 PG 9 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA DC7DA UT WOS:000369377800004 PM 26416334 ER PT J AU Kang, T Louden, JE Ricks, EP Jones, RL AF Kang, Tamara Louden, Jennifer Eno Ricks, Elijah P. Jones, Rachell L. TI Aggression, Substance Use Disorder, and Presence of a Prior Suicide Attempt Among Juvenile Offenders With Subclinical Depression SO LAW AND HUMAN BEHAVIOR LA English DT Article DE aggression; juvenile offenders; subclinical depression; substance abuse; suicide ID SELF-MEDICATION HYPOTHESIS; MENTAL-HEALTH COURT; PERSONALITY-DISORDERS; PSYCHIATRIC-DISORDERS; CRIMINAL RECIDIVISM; NATIONAL COHORT; DSM-V; RISK; ADOLESCENCE; DELINQUENCY AB Juvenile justice agencies often use the presence of a Diagnostic and Statistical Manual of Mental Disorders (DSM) diagnosis as a criterion for offenders' eligibility for mental health treatment. However, relying on diagnoses to sort offenders into discrete categories ignores subclinical disorders-impairment that falls below the threshold of DSM criteria. The current study used structured clinical interviews with 489 juvenile offenders to examine aggression, presence of a prior suicide attempt, and substance use disorders among juvenile offenders with subclinical depression compared with juvenile offenders with major depression or no mood disorder. Analyses demonstrated that juvenile offenders with subclinical depression reported significantly more aggression, abuse of substances, and the presence of a prior suicide attempt compared to juvenile offenders with no mood disorder, but did not differ significantly on aggression and substance abuse compared with juvenile offenders with major depression. These results have implications for correctional agencies' policies through which offenders are offered mental health treatment, and provide a first step in identifying early signs of problematic behavior before it worsens. Specifically, the results support the notion that depressive disorders should be viewed along a continuum when determining how to allocate services. C1 [Kang, Tamara; Louden, Jennifer Eno; Ricks, Elijah P.; Jones, Rachell L.] Univ Texas El Paso, Dept Psychol, 500 West Univ Ave, El Paso, TX 79902 USA. [Ricks, Elijah P.] Roosevelt Univ, Dept Psychol, Chicago, IL USA. [Jones, Rachell L.] US Army Res Inst Behav & Social Sci, Ft Leavenworth, KS USA. RP Kang, T (reprint author), Univ Texas El Paso, Dept Psychol, 500 West Univ Ave, El Paso, TX 79902 USA. EM tkang2@miners.utep.edu NR 65 TC 2 Z9 2 U1 2 U2 7 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0147-7307 EI 1573-661X J9 LAW HUMAN BEHAV JI Law Hum. Behav. PD DEC PY 2015 VL 39 IS 6 BP 593 EP 601 DI 10.1037/lhb0000145 PG 9 WC Law; Psychology, Social SC Government & Law; Psychology GA DC7NH UT WOS:000369406600006 PM 26168168 ER PT J AU De Julio, A Ferrari, C Levin, G AF De Julio, Adriana Ferrari, Chiara Levin, Geoffrey TI A Patient with Prolonged Psychosis after Electroconvulsive Therapy SO PSYCHIATRIC ANNALS LA English DT Editorial Material ID DEPRESSION; DELIRIUM C1 [De Julio, Adriana] US Army, Washington, DC USA. [De Julio, Adriana; Ferrari, Chiara] Advocate Lutheran Gen Hos, Dept Psychiat, Park Ridge, IL 60068 USA. [Levin, Geoffrey] Advocate Lutheran Gen Hos, Adult Psychiat, Park Ridge, IL USA. RP De Julio, A (reprint author), Advocate Lutheran Gen Hos, Dept Psychiat, Park Ridge, IL 60068 USA.; De Julio, A (reprint author), Advocate Lutheran Gen Hosp, 1775 Dempster St, Park Ridge, IL 60068 USA. EM adriana.dejulio@advocatehealth.com FU James R. & Helen D. Russell Institute for Research Innovation FX Manuscript review and editing was performed by Suela Sulo, PhD (James R. & Helen D. Russell Institute for Research & Innovation, Advocate Lutheran General Hospital). We thank the James R. & Helen D. Russell Institute for Research & Innovation for support with the manuscript of this article. NR 12 TC 0 Z9 0 U1 1 U2 2 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0048-5713 EI 1938-2456 J9 PSYCHIAT ANN JI Psychiatr. Ann. PD DEC PY 2015 VL 45 IS 12 BP 590 EP 592 DI 10.3928/00485713-20151030-02 PG 3 WC Psychiatry SC Psychiatry GA DC9EL UT WOS:000369523800002 ER PT J AU Tozier, W AF Tozier, William TI The Interservice Physician Assistant Program: The veterans' solution SO JAAPA-JOURNAL OF THE AMERICAN ACADEMY OF PHYSICIAN ASSISTANTS LA English DT Editorial Material C1 [Tozier, William] US Army, Washington, DC 20319 USA. [Tozier, William] Univ Washington, Interserv Phys Assistant Program, Seattle, WA 98195 USA. [Tozier, William] Univ Washington, MEDEX Northwest PA Program, Seattle, WA 98195 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1547-1896 EI 0893-7400 J9 JAAPA-J AM ACAD PHYS JI JAAPA-J. Am. Acad. Physician Assist. PD DEC PY 2015 VL 28 IS 12 BP 14 EP 14 DI 10.1097/01.JAA.0000473371.09631.59 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA DC0HW UT WOS:000368898800002 PM 26556216 ER PT J AU Wildman, RA Gazonas, GA AF Wildman, Raymond A. Gazonas, George A. TI A DYNAMIC ELECTRO-THERMO-MECHANICAL MODEL OF DIELECTRIC BREAKDOWN IN SOLIDS USING PERIDYNAMICS SO JOURNAL OF MECHANICS OF MATERIALS AND STRUCTURES LA English DT Article; Proceedings Paper CT Peridynamic Theory symposium CY JUN, 2014 CL Michigan State Univ, East Lansing, MI HO Michigan State Univ DE dielectric breakdown; peridynamics; electromechanical; multiphysics ID ELASTICITY THEORY; POLYETHYLENE; PHOTOGRAPHY; LIQUIDS; FIELDS AB The electro-thermo-mechanical breakdown of dielectric solids is modeled using peridynamics to describe the brittle fracture of a material under high electric fields. A coupled electrostatic, elastodynamic, thermodynamic model is used wherein electrostatic forces are computed and applied to the mechanical model and temperature effects are included. Fracture is simulated using peridynamics, a reformulation of elasticity that incorporates material failure. Coupling occurs between the electrostatic and mechanical forces and also the electrical material properties: specifically, the Lorentz and Kelvin forces are used to couple the electrostatic fields to the stress fields, conductivity is treated as nonlinear and a function of temperature, and mechanical damage is used to alter the permittivity. Results demonstrate that the method is capable of reproducing branching breakdown patterns seen in experiments using a deterministic method. C1 [Wildman, Raymond A.; Gazonas, George A.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Wildman, RA (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM raymond.a.wildman.civ@mail.mil; george.a.gazonas.civ@mail.mil NR 41 TC 0 Z9 0 U1 7 U2 11 PU MATHEMATICAL SCIENCE PUBL PI BERKELEY PA UNIV CALIFORNIA, DEPT MATHEMATICS, BERKELEY, CA 94720-3840 USA SN 1559-3959 J9 J MECH MATER STRUCT JI J. Mech. Mater. Struct. PD DEC PY 2015 VL 10 IS 5 SI SI BP 613 EP 630 DI 10.2140/jomms.2015.10.613 PG 18 WC Materials Science, Multidisciplinary; Mechanics SC Materials Science; Mechanics GA DC0NL UT WOS:000368914200006 ER PT J AU Simper, N Deveaux, PG Burgess, PL AF Simper, Novae Deveaux, Peter G. Burgess, Pamela L. TI An Unusual Case of Lymphadenopathy Due to Traumatic Foreign-Body-Associated Granulomatous Lymphadenitis SO AMERICAN SURGEON LA English DT Article C1 [Simper, Novae] Indiana Univ Sch Med, Dept Pathol, Indianapolis, IN 46202 USA. [Deveaux, Peter G.] Univ Louisville, Dept Colorectal Surg, Louisville, KY 40292 USA. [Burgess, Pamela L.] Dwight D Eisenhower Army Med Ctr, Dept Gen Surg, Ft Gordon, GA 30905 USA. RP Burgess, PL (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Gen Surg, 300 E Hosp Rd, Ft Gordon, GA 30905 USA. EM burgesspl@gmail.com NR 4 TC 0 Z9 0 U1 0 U2 0 PU SOUTHEASTERN SURGICAL CONGRESS PI CUMMING PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA SN 0003-1348 EI 1555-9823 J9 AM SURGEON JI Am. Surg. PD DEC PY 2015 VL 81 IS 12 BP E422 EP E423 PG 2 WC Surgery SC Surgery GA DB4BR UT WOS:000368458200011 PM 26736150 ER PT J AU Allen, KC Sanchez, CJ Niece, KL Wenke, JC Akers, KS AF Allen, Kahtonna C. Sanchez, Carlos J., Jr. Niece, Krista L. Wenke, Joseph C. Akers, Kevin S. TI Voriconazole Enhances the Osteogenic Activity of Human Osteoblasts In Vitro through a Fluoride-Independent Mechanism SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID UNFOLDED PROTEIN RESPONSE; LUNG-TRANSPLANT RECIPIENT; SIGNALING PATHWAY; HETEROTOPIC OSSIFICATION; INDUCED PERIOSTITIS; TRAUMATIZED MUSCLE; FUNGAL-INFECTIONS; GENE-EXPRESSION; ER STRESS; BONE AB Periostitis, which is characterized by bony pain and diffuse periosteal ossification, has been increasingly reported with prolonged clinical use of voriconazole. While resolution of clinical symptoms following discontinuation of therapy suggests a causative role for voriconazole, the biological mechanisms contributing to voriconazole-induced periostitis are unknown. To elucidate potential mechanisms, we exposed human osteoblasts in vitro to voriconazole or fluconazole at 15 or 200 mu g/ml (reflecting systemic or local administration, respectively), under nonosteogenic or osteogenic conditions, for 1, 3, or 7 days and evaluated the effects on cell proliferation (reflected by total cellular DNA) and osteogenic differentiation (reflected by alkaline phosphatase activity, calcium accumulation, and expression of genes involved in osteogenic differentiation). Release of free fluoride, vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF) was also measured in cell supernatants of osteoblasts exposed to triazoles, with an ion-selective electrode (for free fluoride) and enzyme-linked immunosorbent assays (ELISAs) (for VEGF and PDGF). Voriconazole but not fluconazole significantly enhanced the proliferation and differentiation of osteoblasts. In contrast to clinical observations, no increases in free fluoride levels were detected following exposure to either voriconazole or fluconazole; however, significant increases in the expression of VEGF and PDGF by osteoblasts were observed following exposure to voriconazole. Our results demonstrate that voriconazole can induce osteoblast proliferation and enhance osteogenic activity in vitro. Importantly, and in contrast to the previously proposed mechanism of fluoride-stimulated osteogenesis, our findings suggest that voriconazole-induced periostitis may also occur through fluoride-independent mechanisms that enhance the expression of cytokines that can augment osteoblastic activity. C1 [Allen, Kahtonna C.; Akers, Kevin S.] JBSA Ft Sam Houston, San Antonio Mil Med Ctr, Dept Med, Infect Dis Serv, San Antonio, TX 78234 USA. [Sanchez, Carlos J., Jr.; Niece, Krista L.; Wenke, Joseph C.; Akers, Kevin S.] JBSA Ft Sam Houston, US Army Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, San Antonio, TX USA. RP Akers, KS (reprint author), JBSA Ft Sam Houston, San Antonio Mil Med Ctr, Dept Med, Infect Dis Serv, San Antonio, TX 78234 USA. EM kevin.s.akers.mil@mail.mil FU Combat Casualty Research Program, U.S. Army Medical Research and Materiel Command; Oak Ridge Institute for Science and Education fellowship FX This work was supported by intramural funding from the Combat Casualty Research Program, U.S. Army Medical Research and Materiel Command, to J.C.W. C.J.S. was supported by an Oak Ridge Institute for Science and Education fellowship. NR 46 TC 3 Z9 3 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD DEC PY 2015 VL 59 IS 12 BP 7205 EP 7213 DI 10.1128/AAC.00872-15 PG 9 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA DB2KO UT WOS:000368337300006 PM 26324277 ER PT J AU Carmack, E Polyakov, I Padman, L Fer, I Hunke, E Hutchings, J Jackson, J Kelley, D Kwok, R Layton, C Melling, H Perovich, D Persson, O Ruddick, B Timmermans, ML Toole, J Ross, T Vavrus, S Winsor, P AF Carmack, E. Polyakov, I. Padman, L. Fer, I. Hunke, E. Hutchings, J. Jackson, J. Kelley, D. Kwok, R. Layton, C. Melling, H. Perovich, D. Persson, O. Ruddick, B. Timmermans, M. -L. Toole, J. Ross, T. Vavrus, S. Winsor, P. TI TOWARD QUANTIFYING THE INCREASING ROLE OF OCEANIC HEAT IN SEA ICE LOSS IN THE NEW ARCTIC SO BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY LA English DT Article ID HORIZONTAL DENSITY STRUCTURE; ATLANTIC WATER; BOUNDARY CURRENT; FRAM STRAIT; INTERNAL WAVES; BEAUFORT SEA; YERMAK PLATEAU; PACIFIC WATER; SURFACE-LAYER; CANADA BASIN AB The loss of Arctic sea ice has emerged as a leading signal of global warming. This, together with acknowledged impacts on other components of the Earth system, has led to the term the new Arctic. Global coupled climate models predict that ice loss will continue through the twenty-first century, with implications for governance, economics, security, and global weather. A wide range in model projections reflects the complex, highly coupled interactions between the polar atmosphere, ocean, and cryosphere, including teleconnections to lower latitudes. This paper summarizes our present understanding of how heat reaches the ice base from the original sourcesinflows of Atlantic and Pacific Water, river discharge, and summer sensible heat and shortwave radiative fluxes at the ocean/ice surfaceand speculates on how such processes may change in the new Arctic. The complexity of the coupled Arctic system, and the logistic and technological challenges of working in the Arctic Ocean, require a coordinated interdisciplinary and international program that will not only improve understanding of this critical component of global climate but will also provide opportunities to develop human resources with the skills required to tackle related problems in complex climate systems. We propose a research strategy with components that include 1) improved mapping of the upper- and middepth Arctic Ocean, 2) enhanced quantification of important process, 3) expanded long-term monitoring at key heat-flux locations, and 4) development of numerical capabilities that focus on parameterization of heat-flux mechanisms and their interactions. C1 [Carmack, E.] Fisheries & Oceans Canada, Sidney, BC, Canada. [Carmack, E.] Univ Alaska Fairbanks, Coll Nat Sci & Math, Fairbanks, AK USA. [Polyakov, I.] Univ Alaska Fairbanks, Int Arct Res Ctr, Fairbanks, AK USA. [Polyakov, I.] Univ Alaska Fairbanks, Coll Nat Sci & Math, Fairbanks, AK USA. [Padman, L.] Earth & Space Res, Corvallis, OR USA. [Fer, I.] Univ Bergen, Inst Geophys, Bergen, Norway. [Fer, I.] Univ Bergen, Bjerknes Ctr Climate Res, Bergen, Norway. [Hunke, E.] Los Alamos Natl Lab, Los Alamos, NM USA. [Hutchings, J.] Oregon State Univ, Corvallis, OR 97331 USA. [Jackson, J.] Hakai Inst, Heriot Bay, BC, Canada. [Kelley, D.; Layton, C.; Ruddick, B.] Dalhousie Univ, Halifax, NS, Canada. [Kwok, R.] CALTECH, Jet Prop Lab, Pasadena, CA USA. [Melling, H.] Fisheries & Oceans Canada, Sidney, BC, Canada. [Perovich, D.] US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Persson, O.] Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA. [Timmermans, M. -L.] Yale Univ, New Haven, CT USA. [Toole, J.] Woods Hole Oceanog Inst, Woods Hole, MA 02543 USA. [Vavrus, S.] Univ Wisconsin, Ctr Climat Res, Madison, WI USA. [Winsor, P.] Univ Alaska Fairbanks, Inst Marine Sci, Fairbanks, AK USA. RP Polyakov, I (reprint author), UAF, IARC, POB 757335, Fairbanks, AK 99775 USA. EM igor@iarc.uaf.edu RI Kwok, Ron/A-9762-2008; OI Kwok, Ron/0000-0003-4051-5896; Jackson, Jennifer/0000-0002-2318-8814 FU IARC; College of Natural Science and Mathematics, University of Alaska Fairbanks FX The document reflects contributions and discussions from a Sydney Chapman Chair workshop entitled "An Untersteiner Workshop: On the Role and Consequences of Ocean Heat Flux in Sea Ice Melt," held 19-21 March 2013 at the International Arctic Research Center (IARC) at the University of Alaska Fairbanks. We deeply appreciate the logistics support offer by L. Hinzman, and staff of IARC, and financial support provided by IARC and by the College of Natural Science and Mathematics, University of Alaska Fairbanks. NR 219 TC 11 Z9 11 U1 12 U2 38 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0003-0007 EI 1520-0477 J9 B AM METEOROL SOC JI Bull. Amer. Meteorol. Soc. PD DEC PY 2015 VL 96 IS 12 BP 2079 EP 2105 DI 10.1175/BAMS-D-13-00177.1 PG 27 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA DB4RP UT WOS:000368501100001 ER PT J AU Maldonado, JA Bruins, RB Yang, T Wright, A Dunne, CP Karwe, MV AF Maldonado, Jose Antonio Bruins, Rieks B. Yang, Tom Wright, Alan Dunne, C. Patrick Karwe, Mukund V. TI BROWNING AND ASCORBIC ACID DEGRADATION IN MEALS READY-TO-EAT PEAR RATIONS IN ACCELERATED SHELF LIFE SO JOURNAL OF FOOD PROCESSING AND PRESERVATION LA English DT Article ID CHELATE CATALYZED OXIDATION; ORANGE JUICE; VITAMIN-C; MOLECULAR-OXYGEN; CITRUS JUICE; METAL-ION; STORAGE; CONCENTRATE; KINETICS; DECOMPOSITION AB Pears in syrup in flexible pouches are part of the U.S. Army's Meals Ready-to-Eat rations, which are expected to have a shelf life of 3 years at 26.7C. However, browning during storage was reducing the shelf life. Pear pouches were subjected to complete headspace removal and rotation during retorting for extended shelf life of 45 days at 48.9C. The pears were tested for browning, ascorbic acid and headspace composition during storage. A combination of complete headspace removal and rotation of pouches during retorting increased the acceptability of pear by decreasing ascorbic acid degradation and browning. Aerobic and anaerobic ascorbic acid degradation reactions took place in the pears, with most of the aerobic degradation beginning during retorting. A lag period of several days between different stages of ascorbic acid degradation was detected. Finally, the ascorbic acid loss followed zero-order kinetics, with a reaction rate dependent on the initial concentration. C1 [Maldonado, Jose Antonio; Bruins, Rieks B.; Karwe, Mukund V.] Rutgers State Univ, Dept Food Sci, New Brunswick, NJ 08901 USA. [Yang, Tom; Wright, Alan; Dunne, C. Patrick] US Army, Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. RP Karwe, MV (reprint author), Rutgers State Univ, Dept Food Sci, 65 Dudley Rd, New Brunswick, NJ 08901 USA. EM karwe@aesop.rutgers.edu FU U.S. Government Department of Defense; Defense Logistics Agency project CORANET [SP0103-02-D-0024, 0017, 2028]; New Jersey Agricultural Experimental Station FX The authors would like to acknowledge the U.S. Government Department of Defense and the Defense Logistics Agency project CORANET under contract # SP0103-02-D-0024; delivery order # 0017, Short Term Project (STP) # 2028 "Wet Pack Fruit Quality Improvement" for providing the funding for this project. Additionally, they would also like to acknowledge New Jersey Agricultural Experimental Station for providing additional funding. The authors would also like to acknowledge Truitt Brothers, Inc. (Salem, OR) for allowing us to use their facilities for pilot plant runs and SOPAKCO (Mullins, SC) for providing the samples of the MRE items currently used by the U.S. Army. NR 28 TC 0 Z9 0 U1 6 U2 14 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0145-8892 EI 1745-4549 J9 J FOOD PROCESS PRES JI J. Food Process Preserv. PD DEC PY 2015 VL 39 IS 6 BP 2035 EP 2042 DI 10.1111/jfpp.12446 PG 8 WC Food Science & Technology SC Food Science & Technology GA DA9JZ UT WOS:000368126300164 ER PT J AU Peluso, MJ Valcour, V Ananworanich, J Sithinamsuwan, P Chalermchai, T Fletcher, JLK Lerdlum, S Chomchey, N Slike, B Sailasuta, N Gisslen, M Zetterberg, H Spudich, S AF Peluso, Michael J. Valcour, Victor Ananworanich, Jintanat Sithinamsuwan, Pasiri Chalermchai, Thep Fletcher, James L. K. Lerdlum, Sukalya Chomchey, Nitiya Slike, Bonnie Sailasuta, Napapon Gisslen, Magnus Zetterberg, Henrik Spudich, Serena CA RV254 SEARCH 010 Team SEARCH 011 Study Team TI Absence of Cerebrospinal Fluid Signs of Neuronal Injury Before and After Immediate Antiretroviral Therapy in Acute HIV Infection SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE HIV/AIDS; antiretroviral therapy; neurofilament light chain; neurological injury; neuroinflammation; magnetic resonance spectroscopy ID NEUROFILAMENT PROTEIN NFL; NEUROCOGNITIVE DISORDERS; INDIVIDUALS; SEVERITY; COMPLEX; AIDS AB Background. It is unknown whether neuronal injury begins during acute human immunodeficiency virus (HIV) infection, and whether immediate initiation of combination antiretroviral therapy (cART) prevents neuronal injury. Methods. Cerebrospinal fluid (CSF) neurofilament light chain (NFL), ameasure of axonal injury, was assessed before and after cART initiation in individuals starting treatment during acute or chronic HIV infection. Nonparametric statistics examined relationships between NFL and disease progression, neuroinflammation, and cognitive performance. Results. Before treatment, subjects with acute infection had lower CSF NFL levels, with elevations for their age in 1 of 32 subjects with acute infection (3.1%) and 10 of 32 with chronic infection (31%) (P =.006). This persisted after cART initiation, with 1 of 25 acute (4%) and 4 of 9 chronic subjects (44%) showing elevated NFL levels (P =.01). In acute infection, pre-cART NFL levels were inversely correlated with proton magnetic resonance spectroscopic findings of N-acetylaspartate/creatine in frontal gray matter (r = -0.40; P =.03), frontal white matter (r = -0.46; P =.01), and parietal gray matter (r = -0.47; P=. 01); correlations persisted after treatment in the frontal white matter (r = -0.51; P =.02) and parietal gray matter (r = -0.46; P =.04). Conclusions. CSF NFL levels are not elevated in untreated acute HIV infection or after 6 months of immediately initiated cART but are abnormal in chronic HIV infection before and after treatment. In acute HIV infection, CSF NFL levels are inversely associated with neuroimaging markers of neuronal health. C1 [Peluso, Michael J.] Brigham & Womens Hosp, Dept Med, Boston, MA USA. [Valcour, Victor] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA. [Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Sailasuta, Napapon] Huntington Med Res Inst, Pasadena, CA USA. [Spudich, Serena] Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06510 USA. [Ananworanich, Jintanat; Chalermchai, Thep; Fletcher, James L. K.; Chomchey, Nitiya] Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, Thailand. [Sithinamsuwan, Pasiri] Phramongkutklao Hosp, Dept Internal Med, Div Neurol, Bangkok, Thailand. [Lerdlum, Sukalya] Chulalongkorn Univ, Fac Med, Bangkok 10330, Thailand. [Gisslen, Magnus] Univ Gothenburg, Sahlgrenska Acad, Dept Infect Dis, Inst Biomed, Molndal, Sweden. [Zetterberg, Henrik] Univ Gothenburg, Sahlgrenska Acad, Dept Psychiat & Neurochem, Inst Neurosci & Physiol, Molndal, Sweden. [Zetterberg, Henrik] UCL, Inst Neurol, London, England. RP Spudich, S (reprint author), Yale Univ, Dept Neurol, POB 208018, New Haven, CT 06520 USA. EM serena.spudich@yale.edu FU National Institute of Mental Health, National Institutes of Health [R01MH095613, R01NS061696, R21MH086341]; Sahlgrenska Academy at the University of Gothenburg [ALFGBG-11067]; Swedish Research Council [K2011 58P 20931 01]; US Military HIV Research Program FX This work was supported by the National Institute of Mental Health, National Institutes of Health (grants R01MH095613, R01NS061696, and R21MH086341), The Sahlgrenska Academy at the University of Gothenburg (grant ALFGBG-11067), the Swedish Research Council (grant K2011 58P 20931 01), and the US Military HIV Research Program. Antiretrovirals were generously provided by the Thai Government Pharmaceutical Company, Gilead, Merck, and ViiV Healthcare. NR 26 TC 6 Z9 6 U1 1 U2 4 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD DEC 1 PY 2015 VL 212 IS 11 BP 1759 EP 1767 DI 10.1093/infdis/jiv296 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA DB7BN UT WOS:000368669500011 PM 25995196 ER PT J AU Nagaraja, S Reifman, J Mitrophanov, AY AF Nagaraja, Sridevi Reifman, Jaques Mitrophanov, Alexander Y. TI Computational Identification of Mechanistic Factors That Determine the Timing and Intensity of the Inflammatory Response SO PLOS COMPUTATIONAL BIOLOGY LA English DT Article ID TRANSLATIONAL SYSTEMS BIOLOGY; NECROSIS-FACTOR-ALPHA; SENSITIVITY-ANALYSIS; MATHEMATICAL-MODEL; RHEUMATOID-ARTHRITIS; RESOLUTION; MACROPHAGES; INJURY; MICE; TUBERCULOSIS AB Timely resolution of inflammation is critical for the restoration of homeostasis in injured or infected tissue. Chronic inflammation is often characterized by a persistent increase in the concentrations of inflammatory cells and molecular mediators, whose distinct amount and timing characteristics offer an opportunity to identify effective therapeutic regulatory targets. Here, we used our recently developed computational model of local inflammation to identify potential targets for molecular interventions and to investigate the effects of individual and combined inhibition of such targets. This was accomplished via the development and application of computational strategies involving the simulation and analysis of thousands of inflammatory scenarios. We found that modulation of macrophage influx and efflux is an effective potential strategy to regulate the amount of inflammatory cells and molecular mediators in both normal and chronic inflammatory scenarios. We identified three molecular mediators - tumor necrosis factor-alpha (TNF-alpha), transforming growth factor-beta (TGF-beta), and the chemokine CXCL8 - as potential molecular targets whose individual or combined inhibition may robustly regulate both the amount and timing properties of the kinetic trajectories for neutrophils and macrophages in chronic inflammation. Modulation of macrophage flux, as well as of the abundance of TNF-alpha, TGF-beta, and CXCL8, may improve the resolution of chronic inflammation. C1 [Nagaraja, Sridevi; Reifman, Jaques; Mitrophanov, Alexander Y.] US Army, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Dept Def Biotechnol,High Performance Comp Softwar, Ft Detrick, MD USA. RP Nagaraja, S (reprint author), US Army, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Dept Def Biotechnol,High Performance Comp Softwar, Ft Detrick, MD USA. EM jaques.reifman.civ@mail.mil FU Clinical and Rehabilitative Medicine Research Program of the U.S. Army Medical Research and Materiel Command, Fort Detrick, MD FX The authors were supported by the Clinical and Rehabilitative Medicine Research Program of the U.S. Army Medical Research and Materiel Command, Fort Detrick, MD (http://mrmc.amedd.army.mil/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 76 TC 2 Z9 2 U1 0 U2 0 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-734X EI 1553-7358 J9 PLOS COMPUT BIOL JI PLoS Comput. Biol. PD DEC PY 2015 VL 11 IS 12 AR e1004460 DI 10.1371/journal.pcbi.1004460 PG 26 WC Biochemical Research Methods; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Mathematical & Computational Biology GA DB4ZJ UT WOS:000368521900001 PM 26633296 ER PT J AU Bennett, KL Linton, YM Shija, F Kaddumukasa, M Djouaka, R Misinzo, G Lutwama, J Huang, YM Mitchell, LB Richards, M Tossou, E Walton, C AF Bennett, Kelly Louise Linton, Yvonne-Marie Shija, Fortunate Kaddumukasa, Martha Djouaka, Rousseau Misinzo, Gerald Lutwama, Julius Huang, Yiau-Min Mitchell, Luke B. Richards, Miriam Tossou, Eric Walton, Catherine TI Molecular Differentiation of the African Yellow Fever Vector Aedes bromeliae (Diptera: Culicidae) from Its Sympatric Nonvector Sister Species, Aedes lilii SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID EAST-AFRICA; SEQUENCE VARIATION; CHIKUNGUNYA VIRUS; DNA BARCODES; IDENTIFICATION; OUTBREAK; MOSQUITOS; REGION; EPIDEMIC; DISEASE AB Introduction Yellow fever continues to be a problem in sub-Saharan Africa with repeated epidemics occurring. The mosquito Aedes bromeliae is a major vector of yellow fever, but it cannot be readily differentiated from its non-vector zoophilic sister species Ae. lilii using morphological characters. Genetic differences have been reported between anthropophilic Ae. bromeliae and zoophilic Ae. lilii and between forest and domestic populations. However, due to the application of different molecular markers and non-overlapping populations employed in previous studies, interpretation of species delimitation is unclear. Methodology/Principle Findings DNA sequences were generated from specimens of Ae. simpsoni s. l. from the Republic of Benin, Tanzania and Uganda for two nuclear genes apolipophorin 2 (apoLp2) and cytochrome p450 (CYPJ92), the ribosomal internal transcribed spacer region (ITS) and the mitochondrial cytochrome c oxidase (COI) barcoding region. Nuclear genes apoLp2 and CYPJ92 were unable to differentiate between species Ae. bromeliae and Ae. lilii due to ancestral lineage sorting, while ITS sequence data provided clear topological separation on a phylogeny. The standard COI barcoding region was shown to be subject to species introgression and unable to clearly distinguish the two taxa. Here we present a reliable direct PCR-based method for differentiation of the vector species Ae. bromeliae from its isomorphic, sympatric and non-biomedically important sister taxon, Ae. lilii, based on the ITS region. Using molecular species verification, we describe novel immature habitats for Ae. lilii and report both sympatric and allopatric populations. Whereas only Ae. lilii is found in the Republic of Benin and only Ae. bromeliae in Tanzania, both species are sympatric in Uganda. Conclusions/Significance Our accurate identification method will allow informed distribution and detailed ecological studies that will facilitate assessment of arboviral disease risk and development of future targeted vector control. C1 [Bennett, Kelly Louise; Shija, Fortunate; Walton, Catherine] Univ Manchester, Computat Evolutionary Biol Grp, Fac Life Sci, Manchester, Lancs, England. [Linton, Yvonne-Marie; Huang, Yiau-Min; Mitchell, Luke B.] Smithsonian Inst Museum Support Ctr, Walter Reed Biosystemat Unit, Suitland, MD USA. [Linton, Yvonne-Marie] Walter Reed Army Inst Res, Silver Spring, MD USA. [Linton, Yvonne-Marie] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Linton, Yvonne-Marie; Huang, Yiau-Min; Mitchell, Luke B.] Natl Museum Nat Hist, Dept Entomol, Smithsonian Inst, Washington, DC 20560 USA. [Shija, Fortunate; Misinzo, Gerald; Richards, Miriam] Sokoine Univ Agr, Dept Vet Microbiol & Parasitol, Morogoro, Tanzania. [Kaddumukasa, Martha; Lutwama, Julius] Uganda Virus Res Inst, Dept Arbovirol Emerging & Re Eemerging Infect, Entebbe, Uganda. [Djouaka, Rousseau; Tossou, Eric] Agroecohlth Platform West & Cent Africa, Int Inst Trop Agr, Porto Novo, Benin. RP Bennett, KL (reprint author), Univ Manchester, Computat Evolutionary Biol Grp, Fac Life Sci, Manchester, Lancs, England. EM Catherine.walton@manchester.ac.uk FU Royal Society; Leverhulme Trust [(AA110092]; Natural Environment Research Council [NE/H525170/1, NE/1528134/1, NE/J500057/1]; National Research Council (NRC) FX This work was supported by an Africa Award from the Royal Society and Leverhulme Trust (AA110092) and a PhD studentship to KLB funded by the Natural Environment Research Council [NE/H525170/1, NE/1528134/1, NE/J500057/1]. This manuscript was prepared whilst YML held a National Research Council (NRC) Research Associateship Award at the Walter Reed Army Institute of Research. The material to be published reflects the views of the authors and should not be construed to represent those of the Department of the Army or the Department of Defense. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 72 TC 1 Z9 1 U1 1 U2 11 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD DEC PY 2015 VL 9 IS 12 AR e0004250 DI 10.1371/journal.pntd.0004250 PG 19 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA DB2NG UT WOS:000368345100027 PM 26641858 ER PT J AU Clapham, H Cummings, DAT Nisalak, A Kalayanarooj, S Thaisomboonsuk, B Klungthong, C Fernandez, S Srikiatkhachorn, A Macareo, LR Lessler, J Reiser, J Yoon, IK AF Clapham, Hannah Cummings, Derek A. T. Nisalak, Ananda Kalayanarooj, Siripen Thaisomboonsuk, Butsaya Klungthong, Chonticha Fernandez, Stefan Srikiatkhachorn, Anon Macareo, Louis R. Lessler, Justin Reiser, Julia Yoon, In-Kyu TI Epidemiology of Infant Dengue Cases Illuminates Serotype-Specificity in the Interaction between Immunity and Disease, and Changes in Transmission Dynamics SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID HEMORRHAGIC-FEVER; ANTIBODY-RESPONSE; VIRUS; PATHOGENESIS; INFECTIONS; THAILAND; PROTECTION; SEVERITY; ANTIGEN; VACCINE AB Background Infants born to dengue immune mothers acquire maternal antibodies to dengue. These antibodies, though initially protective, decline during the first year of life to levels thought to be disease enhancing, before reaching undetectable levels. Infants have long been studied to understand the interaction between infection and disease on an individual level. Methods/Findings Considering infants (cases < 1 year old) as a unique group, we analyzed serotype specific dengue case data from patients admitted to a pediatric hospital in Bangkok, Thailand. We show differences in the propensity of serotypes to cause disease in individuals with dengue antibodies (infants and post-primary cases) and in individuals without dengue antibodies (primary cases). The mean age of infant cases differed among serotypes, consistent with previously observed differential waning of maternal antibody titers by serotype. We show that trends over time in epidemiology of infant cases are consistent with those observed in the whole population, and therefore with trends in the force of infection. Conclusions/Significance Infants with dengue are informative about the interaction between antibody and the dengue serotypes, confirming that in this population DENV-2 and DENV-4 almost exclusively cause disease in the presence of dengue antibody despite infections occurring in others. We also observe differences between the serotypes in the mean age in infant cases, informative about the interaction between waning immunity and disease for the different serotypes in infants. In addition, we show that the mean age of infant cases over time is informative about transmission in the whole population. Therefore, ongoing surveillance for dengue in infants could provide useful insights into dengue epidemiology, particularly after the introduction of a dengue vaccine targeting adults and older children. C1 [Clapham, Hannah; Cummings, Derek A. T.; Reiser, Julia] Johns Hopkins Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21218 USA. [Cummings, Derek A. T.] Univ Florida, Dept Biol, Gainesville, FL USA. [Nisalak, Ananda; Thaisomboonsuk, Butsaya; Klungthong, Chonticha; Fernandez, Stefan; Macareo, Louis R.; Reiser, Julia] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. [Srikiatkhachorn, Anon] Univ Massachusetts, Sch Med, Dept Med, Div Infect Dis & Immunol, Worcester, MA USA. [Yoon, In-Kyu] Int Vaccine Inst, Dengue Vaccine Initiat, Seoul, South Korea. RP Clapham, H (reprint author), Johns Hopkins Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21218 USA. EM hclapha1@jhu.edu OI Lessler, Justin/0000-0002-9741-8109 FU National Institute of General Medical Sciences of the National Institutes of Health [U54 GM088491]; National Institutes of Health [5R01AI102939-03]; National Institute of Allergy and Infectious Diseases [5P01 AI034533-22]; [R01Al114703] FX The views expressed in this article are those of the authors and do not represent the official policy or position of the US Department of the Army, Department of Defense, or US Government. DATC received funding from the National Institute of General Medical Sciences of the National Institutes of Health under Award Number U54 GM088491 and received funding from grant R01Al114703. HC, JL and DATC received funding from the National Institutes of Health under Award Number 5R01AI102939-03. AS received funding from the National Institute of Allergy and Infectious Diseases under Award Number 5P01 AI034533-22. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 30 TC 0 Z9 0 U1 0 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD DEC PY 2015 VL 9 IS 12 AR e0004262 DI 10.1371/journal.pntd.0004262 PG 10 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA DB2NG UT WOS:000368345100037 PM 26658730 ER PT J AU Kelly, DJ Foley, DH Richards, AL AF Kelly, Daryl J. Foley, Desmond H. Richards, Allen L. TI A Spatiotemporal Database to Track Human Scrub Typhus Using the VectorMap Application SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Review ID POLYMERASE-CHAIN-REACTION; WEIL-FELIX REACTION; ORIENTIA-TSUTSUGAMUSHI; INDIRECT IMMUNOFLUORESCENCE; RICKETTSIA-TSUTSUGAMUSHI; MURINE TYPHUS; DIAGNOSIS; THAILAND; DISEASE; DIVERSITY AB Scrub typhus is a potentially fatal mite-borne febrile illness, primarily of the Asia-Pacific Rim. With an endemic area greater than 13 million km2 and millions of people at risk, scrub typhus remains an underreported, often misdiagnosed febrile illness. A comprehensive, updatable map of the true distribution of cases has been lacking, and therefore the true risk of disease within the very large endemic area remains unknown. The purpose of this study was to establish a database and map to track human scrub typhus. An online search using PubMed and the United States Armed Forces Pest Management Board Literature Retrieval System was performed to identify articles describing human scrub typhus cases both within and outside the traditionally accepted endemic regions. Using World Health Organization guidelines, stringent criteria were used to establish diagnoses for inclusion in the database. The preliminary screening of 181 scrub typhus publications yielded 145 publications that met the case criterion, 267 case records, and 13 serosurvey records that could be georeferenced, describing 13,739 probable or confirmed human cases in 28 countries. A map service has been established within VectorMap (www.vectormap.org) to explore the role that relative location of vectors, hosts, and the pathogen play in the transmission of mite-borne scrub typhus. The online display of scrub typhus cases in VectorMap illustrates their presence and provides an up-to-date geographic distribution of proven scrub typhus cases. C1 [Kelly, Daryl J.; Richards, Allen L.] Naval Med Res Ctr, Viral & Rickettsial Dis Dept, Silver Spring, MD 20910 USA. [Kelly, Daryl J.] Ohio State Univ, Dept Evolut Ecol & Organismal Biol, Columbus, OH 43210 USA. [Foley, Desmond H.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD USA. [Richards, Allen L.] Uniformed Serv Univ Hlth Sci, Prevent Med & Biometr Dept, Bethesda, MD 20814 USA. RP Kelly, DJ (reprint author), Naval Med Res Ctr, Viral & Rickettsial Dis Dept, Silver Spring, MD 20910 USA. EM kelly.350@osu.edu OI Foley, Desmond/0000-0001-7525-4601 FU Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response Systems, Silver Spring, MD; [P0181_14_WR] FX This study was financially supported by the Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response Systems, Silver Spring, MD (https://www.afhsc.mil/Home/Divisions/GEIS), under a Memorandum of Understanding between the Walter Reed Army Institute of Research and the Smithsonian Institution, with institutional support provided by both organizations. Grant to DHF: grant # P0181_14_WR. ALR is an employee of the US Government and his work was prepared as part of his official duties. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 43 TC 2 Z9 2 U1 2 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD DEC PY 2015 VL 9 IS 12 AR e0004161 DI 10.1371/journal.pntd.0004161 PG 13 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA DB2NG UT WOS:000368345100007 PM 26678263 ER PT J AU Cochet, AE Cunningham, JR Butler, SL AF Cochet, Allyson E. Cunningham, John Ryan Butler, Samantha L. TI Pseudomelanosis duodeni and Strongyloides stercoralis SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Editorial Material C1 [Cochet, Allyson E.; Cunningham, John Ryan; Butler, Samantha L.] Brooke Army Med Ctr, San Antonio, TX 78234 USA. RP Cochet, AE (reprint author), Brooke Army Med Ctr, San Antonio, TX 78234 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD DEC PY 2015 VL 110 IS 12 BP 1651 EP 1651 DI 10.1038/ajg.2015.113 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA DB1NJ UT WOS:000368274700005 PM 26673486 ER PT J AU Tannenbaum, LV Flaws, JA AF Tannenbaum, Lawrence V. Flaws, Jodi A. TI Exposure Duration-Dependent Ovarian Recovery in Methoxychlor-Treated Mice SO BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY LA English DT Article DE methoxychlor; antral follicle; atresia; ovary; recovery ID ATRESIA; MOUSE; RISK AB The pesticide methoxychlor (MXC) is known to target ovarian antral follicles in the mouse. In previous in vivo studies, fertility immediately after dosing. Thus, we hypothesized that perhaps not enough time had elapsed between the onset ofMXC-induced atresia and actual follicle loss to result in reduced fertility. The current study was undertaken to determine whether MXC treatment for 20 days results in reduced antral follicle numbers and fertility at 30 and 60 days after dosing. To test this hypothesis, adult CD-1 female mice were dosed with vehicle control or MXC (64 mg/kg/day) for 20 days. At 30 and 60 days postdosing, the mice were either subjected to fertility tests or their ovaries were collected and subjected to histological evaluation of follicle numbers and atresia. The results indicate that at 30 days after the completion of dosing, MXC significantly increased atresia and reduced primordial and total follicle numbers, but did not affect fertility compared to controls. At 60 days after completion of dosing, MXC did not significantly affect fertility, follicle numbers, or atresia compared to controls. Collectively, these data indicate that the ovary may be able to recover from MXC treatment for 20 days. (C) 2015 Wiley Periodicals, Inc. C1 [Tannenbaum, Lawrence V.] US Army, Publ Hlth Ctr, Aberdeen Proving Ground, MD USA. [Flaws, Jodi A.] Univ Illinois, Dept Comparat Biosci, Urbana, IL 61802 USA. RP Flaws, JA (reprint author), Univ Illinois, Dept Comparat Biosci, 2001 S Lincoln Ave, Urbana, IL 61802 USA. EM jflaws@illinois.edu FU Eunice Kennedy Shriver NICHD/NIH (NCTRI) [P50-HD28934] FX The authors thank Liying Gao and Emily Brehm for the assistance with the ovarian histological evaluations and they thank Sherri Hutchens and Jeffrey Leach for the manuscript review. The University of Virginia Center for Research in Reproduction Ligand Assay and Analysis Core is supported by the Eunice Kennedy Shriver NICHD/NIH (NCTRI) Grant P50-HD28934. NR 21 TC 0 Z9 0 U1 1 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-9733 EI 1542-9741 J9 BIRTH DEFECTS RES B JI Birth Defects Res. Part B-Dev. Reprod. Toxicol. PD DEC PY 2015 VL 104 IS 6 BP 238 EP 243 DI 10.1002/bdrb.21164 PG 6 WC Oncology; Genetics & Heredity; Toxicology SC Oncology; Genetics & Heredity; Toxicology GA DB0FD UT WOS:000368183100002 PM 26551443 ER PT J AU Kilianski, A Murch, RS AF Kilianski, Andy Murch, Randall S. TI When gain-of-function research is not "gain-of-function" research SO EMBO REPORTS LA English DT Editorial Material ID VIRUS; TRANSMISSION; FERRETS C1 [Kilianski, Andy] US Army Edgewood Chem Biol Ctr, Biodef Branch, BioSci Div, Aberdeen Proving Ground, MD 21010 USA. [Murch, Randall S.] Off Vice President, Arlington, VA USA. [Murch, Randall S.] Sch Publ & Int Affairs, Arlington, VA USA. [Murch, Randall S.] Virginia Tech Univ, Dept Plant Pathol Physiol & Weed Sci, Arlington, VA USA. RP Kilianski, A (reprint author), US Army Edgewood Chem Biol Ctr, Biodef Branch, BioSci Div, Aberdeen Proving Ground, MD 21010 USA. EM andrew.kilianski.ctr@mail.mil NR 10 TC 1 Z9 1 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1469-221X EI 1469-3178 J9 EMBO REP JI EMBO Rep. PD DEC PY 2015 VL 16 IS 12 BP 1586 EP 1587 PG 2 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA DB0ZH UT WOS:000368237100003 PM 26538418 ER PT J AU Whitehouse, CA Chase, K Embers, ME Kulesh, DA Ladner, JT Palacios, GF Minogue, TD AF Whitehouse, Chris A. Chase, Kitty Embers, Monica E. Kulesh, David A. Ladner, Jason T. Palacios, Gustavo F. Minogue, Timothy D. TI Development of real-time PCR assays for the detection of Moraxella macacae associated with bloody nose syndrome in rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) macaques SO JOURNAL OF MEDICAL PRIMATOLOGY LA English DT Article DE epistaxis; molecular diagnostics; non-human primates; veterinary microbiology ID NONHUMAN-PRIMATES; CATARRHALIS; EPISTAXIS; GENERA; FLORA AB Background Moraxella macacae is a recently described bacterial pathogen that causes epistaxis or so-called bloody nose syndrome in captive macaques. The aim of this study was to develop specific molecular diagnostic assays for M. macacae and to determine their performance characteristics. Methods We developed six real-time PCR assays on the Roche LightCycler. The accuracy, precision, selectivity, and limit of detection (LOD) were determined for each assay, in addition to further validation by testing nasal swabs from macaques presenting with epistaxis at the Tulane National Primate Research Center. Results All assays exhibited 100% specificity and were highly sensitive with an LOD of 10 fg for chromosomal assays and 1 fg for the plasmid assay. Testing of nasal swabs from 10 symptomatic macaques confirmed the presence of M. macacae in these animals. Conclusions We developed several accurate, sensitive, and species-specific real-time PCR assays for the detection of M. macacae in captive macaques. C1 [Whitehouse, Chris A.] US Army, Med Res Inst Infect Dis, Mol & Translat Sci Div, Ft Detrick, MD 21702 USA. [Chase, Kitty; Kulesh, David A.; Minogue, Timothy D.] US Army, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. [Embers, Monica E.] Tulane Univ Hlth Sci, Tulane Natl Primate Res Ctr, Div Bacteriol & Parasitol, Covington, LA USA. [Ladner, Jason T.; Palacios, Gustavo F.] US Army, Med Res Inst Infect Dis, Ctr Genome Sci, Ft Detrick, MD 21702 USA. RP Minogue, TD (reprint author), US Army, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. EM timothy.d.minogue.civ@mail.mil RI Palacios, Gustavo/I-7773-2015 OI Palacios, Gustavo/0000-0001-5062-1938 FU Defense Threat Reduction Agency [1881290] FX We thank Gail Plauche at the TNPRC for excellent clinical microbiology laboratory support and Lorraine Farinick for figure preparation. The research described in this report was made possible by financial support provided by the Defense Threat Reduction Agency Project No. 1881290. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. NR 16 TC 0 Z9 0 U1 1 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0047-2565 EI 1600-0684 J9 J MED PRIMATOL JI J. Med. Primatol. PD DEC PY 2015 VL 44 IS 6 BP 364 EP 372 DI 10.1111/jmp.12196 PG 9 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA DB1ID UT WOS:000368260900003 PM 26365904 ER PT J AU Kocifaj, M Klacka, J Kundracik, F Videen, G AF Kocifaj, Miroslav Klacka, Jozef Kundracik, Frantisek Videen, Gorden TI Charge-induced electromagnetic resonances in nanoparticles SO ANNALEN DER PHYSIK LA English DT Article ID DUST PARTICLES; SCATTERING; WAVES; SPHERE AB Electromagnetic theories have reproduced the scattering properties of differently shaped particles and successfully been used to characterize numerous systems. However, certain anomalous features remain unexplained that include enhanced extinction when particles are much smaller than the wavelength. Here we explain these features exploiting recent research in electromagnetic scattering theories that suggests incorporating the effect of particle charge results in new physical outcomes that deviate appreciably from what is predicted by electromagnetic interaction from uncharged systems. For electrically charged particles, the resonant excitation of surface modes is governed by excess charges deposited on the particle surface. Charge effects become large when particles are small compared to the incident wavelength, and we show that the electrostatic approximation is not valid for modelling the electromagnetic interaction from such particles. Charge-induced resonances appear in such systems that can reproduce previously unexplained phenomena, for instance, amplified microwave attenuation observed in sandstorms. C1 [Kocifaj, Miroslav] Slovak Acad Sci, ICA, Bratislava 84503, Slovakia. [Kocifaj, Miroslav; Klacka, Jozef; Kundracik, Frantisek] Comenius Univ, Fac Math Phys & Informat, Bratislava 84248, Slovakia. [Videen, Gorden] US Army Res Lab, AMSRD ARL CI ES, Adelphi, MD 20783 USA. RP Kocifaj, M (reprint author), Slovak Acad Sci, ICA, Dubravska Rd 9, Bratislava 84503, Slovakia. EM kocifaj@savba.sk FU US Army International Technology Center (RD) [W911NF-14-1-0601, 1695-PH-01]; Slovak National Grant Agency VEGA [2/0002/12] FX This work was supported by the US Army International Technology Center under the contract No: W911NF-14-1-0601 (R&D 1695-PH-01). Computational work was supported by the Slovak National Grant Agency VEGA (grant No. 2/0002/12). The authors of near field codes for spheres, Peter W. Barber and Steven Hill, are gratefully acknowledged. NR 25 TC 5 Z9 5 U1 2 U2 8 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 0003-3804 EI 1521-3889 J9 ANN PHYS-BERLIN JI Ann. Phys.-Berlin PD DEC PY 2015 VL 527 IS 11-12 BP 765 EP 769 DI 10.1002/andp.201500202 PG 5 WC Physics, Multidisciplinary SC Physics GA DA3CH UT WOS:000367673000002 ER PT J AU Kott, A Alberts, DS Wang, C AF Kott, Alexander Alberts, David S. Wang, Cliff TI Will Cybersecurity Dictate the Outcome of Future Wars? SO COMPUTER LA English DT Article C1 [Kott, Alexander] US Army Res Lab, Network Sci Div, Adelphi, MD 20783 USA. [Alberts, David S.] Inst Def Anal, New Delhi, India. [Wang, Cliff] US Army Res Off, Div Comp Sci, West Point, PA USA. RP Kott, A (reprint author), US Army Res Lab, Network Sci Div, Adelphi, MD 20783 USA. EM alexander.kott1.civ@mail.mil; dalberts@ida.org; cliff.x.wang.civ@mail.mil NR 9 TC 1 Z9 1 U1 0 U2 3 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 0018-9162 EI 1558-0814 J9 COMPUTER JI Computer PD DEC PY 2015 VL 48 IS 12 BP 98 EP 101 PG 4 WC Computer Science, Hardware & Architecture; Computer Science, Software Engineering SC Computer Science GA DA3IC UT WOS:000367689400014 ER PT J AU Wilkens, JL Katzenmeyer, AW Hahn, NM Hoover, JJ Suedel, BC AF Wilkens, J. L. Katzenmeyer, A. W. Hahn, N. M. Hoover, J. J. Suedel, B. C. TI Laboratory test of suspended sediment effects on short-term survival and swimming performance of juvenile Atlantic sturgeon (Acipenser oxyrinchus oxyrinchus, Mitchill, 1815) SO JOURNAL OF APPLIED ICHTHYOLOGY LA English DT Article ID SOUTHERN APPALACHIAN MINNOWS; SALMON ONCORHYNCHUS-KISUTCH; SHOVELNOSE STURGEON; SCAPHIRHYNCHUS-ALBUS; PALLID STURGEON; PHYSIOLOGICAL-RESPONSES; LAKE STURGEON; FRESH-WATER; FISH; BEHAVIOR AB Tested was the hypothesis that juvenile Atlantic sturgeon (Acipenser oxyrinchus oxyrinchus) would exhibit no response in short-term survival or swimming performance when exposed to varying concentrations of suspended sediment simulating dredge plumes in waterways where this species may be impacted by dredging operations. Sediment collected from Savannah Harbor, South Carolina, USA was used to simulate a worst-case scenario. Juvenile sturgeon were contained for a 3-day period in flow-through aquaria, with limited opportunity for movement, in sediment of varying concentrations (100, 250 and 500 mg L-1 total suspended solids [TSS]) mimicking prolonged exposure to suspended sediment plumes near an operating dredge. Of the 90 fish exposed, 86 (96%) survived the test. Of the four fish that died, one was exposed to 250 TSS and three to 500 TSS. Swimming performance results indicated that nearly all fish were positively rheotactic. Critical swim speeds (U-crits) were moderate, whether measured as absolute values (21-31 cm s(-1)) or as relative values (1.4-2.1 body lengths s(-1)), with no significant differences among treatments (F < 0.83, P >= 0.4874). Behavior was dominated by contact-based locomotion and station-holding. Absence of substantial or significant immediate effects on survival and swimming performance suggest that impacts of sediment plumes in nature, where fish have freedom of movement and the power to escape rapidly, are minimal. C1 [Wilkens, J. L.; Katzenmeyer, A. W.; Hahn, N. M.; Hoover, J. J.; Suedel, B. C.] US Army, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Suedel, BC (reprint author), US Army, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM burton.suedel@usace.army.mil FU Dredging Operations and Environmental Research Program FX Our thanks to Kent Ware, Bears Bluff National Fish Hatchery, Wadmalaw Island, South Carolina, USA for supplying the fish used in this study; Cynthia Williams, U.S. Fish and Wildlife Service, for assistance in facilitating the permitting process (Permit No. 17367); and Dennis Riecke and Charles Silkwood, Mississippi Department of Wildlife Fisheries and Parks, for the loan of the fish hauler. Sturgeon were held under the ERDC Environmental Laboratory's Institutional Animal Care and Use Protocol No. EL-5036-2012-1, and the experiment was conducted under Protocol No. EL-6008-2013-1. We also thank Jack Killgore, USACE ERDC, for his helpful insight and for reviewing an earlier version of the paper. This research was funded by the Dredging Operations and Environmental Research Program, Todd Bridges, Director. Permission to publish was provided by the Chief of Engineers. NR 49 TC 0 Z9 0 U1 4 U2 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0175-8659 EI 1439-0426 J9 J APPL ICHTHYOL JI J. Appl. Ichthyol. PD DEC PY 2015 VL 31 IS 6 BP 984 EP 990 DI 10.1111/jai.12875F PG 7 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA DA3GE UT WOS:000367684400002 ER PT J AU Eckold, P Sellers, MS Niewa, R Hugel, W AF Eckold, P. Sellers, M. S. Niewa, R. Huegel, W. TI The surface energies of beta-Sn - A new concept for corrosion and whisker mitigation SO MICROELECTRONICS RELIABILITY LA English DT Article DE Surface energy; Tin corrosion; Whisker growth; Electrodeposition; EBSD analysis ID LEAD-FREE SOLDERS; METHANESULFONIC-ACID ELECTROLYTE; TIN-LEAD; NACL SOLUTION; GROWTH; COATINGS; ELECTRODEPOSITION; ELECTRONICS; MECHANISMS; PARAMETERS AB Corrosion data provided under high-temperature and high-humidity conditions as well as tin whisker growth studies are explained by differences in the surface energy of lattice planes within the crystal structure of beta-tin. For this purpose, electrodeposited tin finishes were investigated regarding their microstructure utilizing X-ray diffraction, cross-sectional SEM and EBSD analyses. The corrosion as well as the tin whisker propensity strongly depends on the preferred orientation of the surface finishes. With an increasing texture along the (211) lattice plane a decreasing corrosion and whisker propensity were observed, on the contrary, the presence of the (101) and (112) textures results in an increased corrosion and whisker propensity. The maximum whisker length was reduced by one order of magnitude by changing the preferred orientation towards the (211) lattice plane of the tin finish. Modified embedded atom method simulations of tin surfaces demonstrate the minimization of the surface energy of (211) surfaces, whereas the surface energies of the (101) and (112) Miller planes are increased. We find a strong connection between the minimization of surface energy and the corrosion and tin whisker propensity of electrodeposited tin finishes. To our best knowledge, this is the first study connecting the influence of the electrodeposition parameters on the corrosion and whisker propensity explained by calculations of the surface energies of the corresponding crystal faces. The applied parameters for electrodeposition influence the grain orientation and thus the surface energy of the tin layers which affects both the corrosion as well as the tin whisker propensity. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Eckold, P.; Niewa, R.] Univ Stuttgart, Inst Inorgan Chem, D-70565 Stuttgart, Germany. [Eckold, P.; Huegel, W.] Robert Bosch GmbH, Automot Elect, D-70442 Stuttgart, Germany. [Sellers, M. S.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Eckold, P (reprint author), Univ Stuttgart, Inst Inorgan Chem, Pfaffenwaldring 55, D-70565 Stuttgart, Germany. EM Pierre.Eckold@de.bosch.com FU Robert Bosch GmbH FX The authors would like to thank the Robert Bosch GmbH for providing the financial support for this research in the scope of a PhD study. M.S. Sellers performed his portion of research independent of U.S. Army Research Laboratory interest and resources, and no financial support was provided by the US. Army Research Laboratory or any United States Government entity. In addition, we are deeply obliged to the electrolyte supplier for providing the required plating chemistries. NR 50 TC 1 Z9 1 U1 4 U2 13 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0026-2714 J9 MICROELECTRON RELIAB JI Microelectron. Reliab. PD DEC PY 2015 VL 55 IS 12 BP 2799 EP 2807 DI 10.1016/j.microrel.2015.08.018 PN B PG 9 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA DA4MF UT WOS:000367773300025 ER PT J AU Leguia, M Loyola, S Rios, J Juarez, D Guevara, C Silva, M Prieto, K Wiley, M Kasper, MR Palacios, G Bausch, DG AF Leguia, Mariana Loyola, Steev Rios, Jane Juarez, Diana Guevara, Carolina Silva, Maria Prieto, Karla Wiley, Michael Kasper, Matthew R. Palacios, Gustavo Bausch, Daniel G. TI Full Genomic Characterization of a Saffold Virus Isolated in Peru SO PATHOGENS LA English DT Article DE Saffold virus; Cardiovirus; full genome; Peru ID ENCEPHALOMYOCARDITIS VIRUS; RESPIRATORY PATHOGENS; DIVERSITY; ILLNESS AB While studying respiratory infections of unknown etiology we detected Saffold virus in an oropharyngeal swab collected from a two-year-old female suffering from diarrhea and respiratory illness. The full viral genome recovered by deep sequencing showed 98% identity to a previously described Saffold strain isolated in Japan. Phylogenetic analysis confirmed the Peruvian Saffold strain belongs to genotype 3 and is most closely related to strains that have circulated in Asia. This is the first documented case report of Saffold virus in Peru and the only complete genomic characterization of a Saffold-3 isolate from the Americas. C1 [Leguia, Mariana; Loyola, Steev; Rios, Jane; Juarez, Diana; Guevara, Carolina; Silva, Maria; Kasper, Matthew R.; Bausch, Daniel G.] US Naval Med Res Unit No 6 NAMRU 6, Callao 2, Peru. [Prieto, Karla; Wiley, Michael; Palacios, Gustavo] US Army, Med Res Inst Infect Dis, Ctr Genome Sci, Frederick, MD 21702 USA. [Bausch, Daniel G.] Tulane Sch Publ Hlth & Trop Med, New Orleans, LA 70112 USA. RP Leguia, M (reprint author), US Naval Med Res Unit No 6 NAMRU 6, Callao 2, Peru. EM mariana.leguia.fn@mail.mil; steev.loyola@med.navy.mil; jane.s.rios.fn@mail.mil; diana.s.juarez2.fn@mail.mil; carolina.guevara.fn@mail.mil; maria.e.silva19.fn@mail.mil; karla.prieto.ctr@mail.mil; michael.r.wiley19.ctr@mail.mil; matthew.r.kasper2.mil@mail.mil; gustavo.f.palacios.ctr@mail.mil; bauschd@who.int RI Palacios, Gustavo/I-7773-2015 OI Palacios, Gustavo/0000-0001-5062-1938 NR 19 TC 1 Z9 1 U1 0 U2 2 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2076-0817 J9 PATHOGENS JI Pathogens PD DEC PY 2015 VL 4 IS 4 BP 816 EP 825 DI 10.3390/pathogens4040816 PG 10 WC Microbiology SC Microbiology GA DA1EI UT WOS:000367538700008 PM 26610576 ER PT J AU Travis, CMG Altman, DE Genovese, RF AF Travis, Caitlin M. Groeber Altman, Daniel E. Genovese, Raymond F. TI Ketamine administration diminishes operant responding but does not impair conditioned fear SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR LA English DT Article DE Conditioned fear; Conditioned suppression; Operant conditioning; Stress processes; Ketamine; PTSD ID METHYL-D-ASPARTATE; NONCOMPETITIVE NMDA ANTAGONIST; POSTTRAUMATIC-STRESS-DISORDER; RESISTANT MAJOR DEPRESSION; LONG-TERM POTENTIATION; LOW-DOSE KETAMINE; ANESTHETIC KETAMINE; INTRAVENOUS KETAMINE; RECOGNITION MEMORY; TASTE-AVERSION AB While not well understood, the NMDA (N-methyl-D-aspartate) antagonist ketamine, a dissociative anesthetic, has been reported to be efficacious in depression and related psychological disorders. Conditioned fear is a normal emotional conditioning process that is known to become dysfunctional in individuals suffering from Post-Traumatic Stress Disorder (PTSD) and related stress disorders. We examined the effects of ketamine to determine the potential modulation of the acquisition and extinction of a conditioned fear using a conditioned suppression procedure. Rats were trained on a variable interval (VI), food maintained, operant conditioning task to establish a general measure of performance. Rats were exposed to inescapable shock (IES, unconditioned stimulus) paired (x20) with an audio/visual conditioned stimulus (CS) to establish conditioning. Conditioning was quantified by measuring response suppression following CS presentation during subsequent extinction trials where the CS alone was presented. Ketamine or vehicle was administered either after initial conditioning or after each of the subsequent extinction trials. For each regimen, a series of four injections were administered 60 min apart (100, 50, 50, 50 mg/kg, respectively) in order to sustain a ketamine effect for a minimum of 4 h. Ketamine produced a general decrease in responding on the VI, relative to baseline, as response rates were slower on the operant task when tested 24 h later and longer. Ketamine did not affect the acquisition of the conditioned fear when the regimen was administered shortly after the initial pairings of IES and CS. Ketamine did not alter extinction to the conditioned fear when the regimen was administered following each CS only presentation following initial conditioning. Our conclusion from these findings is that while ketamine alters behavior on an appetitively motivated operant task it does not, however, appear to directly modulate learning and memory processes associated with conditioned fear. (C) 2015 Elsevier Inc. All rights reserved. C1 [Travis, Caitlin M. Groeber; Altman, Daniel E.; Genovese, Raymond F.] Walter Reed Army Inst Res, Behav Biol Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Travis, CMG (reprint author), Walter Reed Army Inst Res, Behav Biol Branch, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM caitlin.m.travis.ctr@mail.mil OI Travis, Caitlin/0000-0002-0113-4225 FU Military Operational Medicine Research Program (MOMRP, Task Area W2), U.S. Army Material Research and Materiel Command FX This research was supported by the Military Operational Medicine Research Program (MOMRP; Task Area W2), U.S. Army Material Research and Materiel Command. Material has been reviewed by the Walter Reed Army Institute of Research. There is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private views of the author, and are not to be construed as official, or as reflecting true views of the Department of the Army or the Department of Defense. NR 60 TC 2 Z9 2 U1 4 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0091-3057 J9 PHARMACOL BIOCHEM BE JI Pharmacol. Biochem. Behav. PD DEC PY 2015 VL 139 BP 84 EP 91 DI 10.1016/j.pbb.2015.10.013 PN A PG 8 WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy GA DA4LX UT WOS:000367772500010 ER PT J AU Borch, FL AF Borch, Fred L. TI Murder in Manila SO PROLOGUE-QUARTERLY OF THE NATIONAL ARCHIVES AND RECORDS ADMINISTRATION LA English DT Article C1 [Borch, Fred L.] Armys Judge Advocate Generals Corps, Ft Bliss, TX 79916 USA. RP Borch, FL (reprint author), Armys Judge Advocate Generals Corps, Ft Bliss, TX 79916 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATL ARCHIVES RECORDS ADMINISTRATION PI WASHINGTON PA TRUST FUND BOARD, WASHINGTON, DC 20408 USA SN 0033-1031 J9 PROLOGUE JI Prologue PD WIN PY 2015 VL 47 IS 4 BP 6 EP 14 PG 9 WC History SC History GA DA4HS UT WOS:000367761600003 ER PT J AU Trefry, JC Wollen, SE Nasar, F Shamblin, JD Kern, SJ Bearss, JJ Jefferson, MA Chance, TB Kugelman, JR Ladner, JT Honko, AN Kobs, DJ Wending, MQS Sabourin, CL Pratt, WD Palacios, GF Pitt, MLM AF Trefry, John C. Wollen, Suzanne E. Nasar, Farooq Shamblin, Joshua D. Kern, Steven J. Bearss, Jeremy J. Jefferson, Michelle A. Chance, Taylor B. Kugelman, Jeffery R. Ladner, Jason T. Honko, Anna N. Kobs, Dean J. Wending, Morgan Q. S. Sabourin, Carol L. Pratt, William D. Palacios, Gustavo F. Pitt, M. Louise M. TI Ebola Virus Infections in Nonhuman Primates Are Temporally Influenced by Glycoprotein Poly-U Editing Site Populations in the Exposure Material SO VIRUSES-BASEL LA English DT Article DE Ebola virus; Kikwit; filovirus; nonhuman primate; glycoprotein; RNA editing; pathogenesis; animal model; vaccine; therapeutic ID HEMORRHAGIC-FEVER; MARBURG VIRUSES; POSTEXPOSURE PROTECTION; DISEASE; VACCINE; RNA; CHALLENGE; MODELS; PATHOGENESIS; SURVIVAL AB Recent experimentation with the variants of the Ebola virus that differ in the glycoprotein's poly-uridine site, which dictates the form of glycoprotein produced through a transcriptional stutter, has resulted in questions regarding the pathogenicity and lethality of the stocks used to develop products currently undergoing human clinical trials to combat the disease. In order to address these concerns and prevent the delay of these critical research programs, we designed an experiment that permitted us to intramuscularly challenge statistically significant numbers of naive and vaccinated cynomolgus macaques with either a 7U or 8U variant of the Ebola virus, Kikwit isolate. In naive animals, no difference in survivorship was observed; however, there was a significant delay in the disease course between the two groups. Significant differences were also observed in time-of-fever, serum chemistry, and hematology. In vaccinated animals, there was no statistical difference in survivorship between either challenge groups, with two succumbing in the 7U group compared to 1 in the 8U challenge group. In summary, survivorship was not affected, but the Ebola virus disease course in nonhuman primates is temporally influenced by glycoprotein poly-U editing site populations. C1 [Trefry, John C.; Wollen, Suzanne E.; Nasar, Farooq; Shamblin, Joshua D.; Kern, Steven J.; Honko, Anna N.; Pratt, William D.; Pitt, M. Louise M.] US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Bearss, Jeremy J.; Jefferson, Michelle A.; Chance, Taylor B.] US Army, Med Res Inst Infect Dis, Div Pathol, Fort Detrick, MD 21702 USA. [Kugelman, Jeffery R.; Ladner, Jason T.; Palacios, Gustavo F.] US Army, Med Res Inst Infect Dis, Mol & Translat Sci, Fort Detrick, MD 21702 USA. [Kobs, Dean J.; Wending, Morgan Q. S.; Sabourin, Carol L.] Battelle Mem Inst, Columbus, OH 43201 USA. RP Trefry, JC (reprint author), US Army, Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA. EM john.c.trefry.ctr@mail.mil; suzanne.e.wollen.ctr@mail.mil; farooq.nasar.ctr@mail.mil; joshua.d.shamblin.civ@mail.mil; kern.steven0@gmail.com; jeremy.j.bearss.mil@mail.mil; michelle.a.jefferson.mil@mail.mil; taylor.b.chance.mil@mail.mil; jeffery.r.kugelman.mil@mail.mil; jason.t.ladner.ctr@mail.mil; anna.honko@nih.gov; kobsd@battelle.org; wendingm@battelle.org; SabourinC@battelle.org; william.d.pratt.civ@mail.mil; gustavo.f.palacios.ctr@mail.mil; margaret.l.pitt.civ@mail.mil RI Palacios, Gustavo/I-7773-2015; OI Palacios, Gustavo/0000-0001-5062-1938; Honko, Anna/0000-0001-9165-148X FU Medical Countermeasures Systems Joint Vaccine Acquisition Program (MCS-JVAP) FX The authors would like to acknowledge the Medical Countermeasures Systems Joint Vaccine Acquisition Program (MCS-JVAP) for funding this study. NR 54 TC 4 Z9 4 U1 1 U2 7 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1999-4915 J9 VIRUSES-BASEL JI Viruses-Basel PD DEC PY 2015 VL 7 IS 12 BP 6739 EP 6754 DI 10.3390/v7122969 PG 16 WC Virology SC Virology GA DA1DO UT WOS:000367536700044 PM 26703716 ER PT J AU Liu, NT Salinas, J AF Liu, Nehemiah T. Salinas, Jose TI Machine learning in burn care and research: A systematic review of the literature SO BURNS LA English DT Review DE Machine learning; Neural networks; Mortality prediction; Burn care; Burn wounds ID ARTIFICIAL NEURAL-NETWORKS; PREDICTION; MEDICINE; CLASSIFICATION; SURVIVAL; INTELLIGENCE; INFORMATION; DIAGNOSIS; COMPUTER; BRAIN AB Background: To date, there are no reviews on machine learning (ML) in burn care. Considering the growth of ML in medicine and the complexities and challenges of burn care, this review specializes on ML applications in burn care. The objective was to examine the features and impact of applications in targeting various aspects of burn care and research. Methods: MEDLINE, the Cochrane Database of Systematic Reviews, Science Direct, and citation review of relevant primary and review articles were searched for studies involving burn care/research and machine learning. Data were abstracted on study design, study size, year, population, application of burn care/research, ML technique(s), and algorithm performance. Results: 15 retrospective observational studies involving burn patients met inclusion criteria. In total 5105 patients with acute thermal injury, 171 clinical burn wounds, 180 9-mer peptides, and 424 12-mer peptides were included in the studies. Studies focused on burn diagnosis (n = 5), aminoglycoside response (n = 3), hospital length of stay (n = 2), survival/mortality (n = 4), burn healing time (n = 1), and antimicrobial peptides in burn patients (n = 1). Of these 15 studies, 11 used artificial neural networks. Importantly, all studies demonstrated the benefits of ML in burn care/research and superior performance over traditional statistical methods. However, algorithm performance was assessed differently by different authors. Feature selection varied among studies, but studies with similar applications shared specific features including age, gender, presence of inhalation injury, total body surface area burned, and when available, various degrees of burns, infections, and previous histories/conditions of burn patients. Conclusion: A common feature base may be determined for ML in burn care/research, but the impact of ML will require further validation in prospective observational studies and randomized clinical trials, establishment of common performance metrics, and high quality evidence about clinical and economic impacts. Only then can ML applications be advanced and accepted widely in burn care/research. (C) 2015 Elsevier Ltd and ISBI. All rights reserved. C1 [Liu, Nehemiah T.; Salinas, Jose] US Army Inst Surg Res, Ft Sam Houston, TX USA. RP Liu, NT (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA. EM nehemiah.liu@us.army.mil; jose.salinas4@us.army.mil FU U.S. Army Combat Casualty Care Research Program FX This work was supported by the U.S. Army Combat Casualty Care Research Program. NR 36 TC 1 Z9 1 U1 2 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 EI 1879-1409 J9 BURNS JI Burns PD DEC PY 2015 VL 41 IS 8 BP 1636 EP 1641 DI 10.1016/j.burns.2015.07.001 PG 6 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA CZ5FK UT WOS:000367127700003 PM 26233900 ER PT J AU Nyland, JE McLean, SA Averitt, DL AF Nyland, Jennifer E. McLean, Samuel A. Averitt, Dayna L. TI Prior stress exposure increases pain behaviors in a rat model of full thickness thermal injury SO BURNS LA English DT Article DE Bum pain; Thermal injury; Hyperalgesia; Allodynia; Stress ID PITUITARY-ADRENAL AXIS; LASTING DELAYED HYPERALGESIA; CHRONIC-FATIGUE-SYNDROME; REPEATED COLD STRESS; SWIM STRESS; GLUCOCORTICOID-RECEPTOR; MECHANICAL ALLODYNIA; BURN PATIENTS; DULOXETINE; EXPRESSION AB Thermal burns among individuals working in highly stressful environments, such as firefighters and military Service Members, are common. Evidence suggests that pre-injury stress may exaggerate pain following thermal injury; however current animal models of burn have not evaluated the potential influence of pre-burn stress. This sham-controlled study evaluated the influence of prior stress exposure on post-bum thermal and mechanical sensitivity in male Sprague-Dawley rats. Rats were exposed to 20 mm of inescapable swim stress or sham stress once per day for three days. Exposure to inescapable swim stress (1) increased the intensity and duration of thermal hyperalgesia after subsequent burn and (2) accelerated the onset of thermal hyperalgesia and mechanical allodynia after subsequent burn. This stress-induced exacerbation of pain sensitivity was reversed by pretreatment and concurrent treatment with the serotonin-norepinephrine reuptake inhibitor (SNRI) duloxetine. These data suggest a better understanding of mechanisms by which prior stress augments pain after thermal burn may lead to improved pain treatments for burn survivors. (C) 2015 Elsevier Ltd and ISBI. All rights reserved. C1 [Nyland, Jennifer E.] US Army Inst Surg Res, Pain Management Res Area, Ft Sam Houston, TX USA. [McLean, Samuel A.] Univ N Carolina, Dept Anesthesiol, Chapel Hill, NC USA. [McLean, Samuel A.] Univ N Carolina, Dept Emergency Med, Chapel Hill, NC USA. [Averitt, Dayna L.] Texas Womans Univ, Dept Biol, Denton, TX 76204 USA. RP Nyland, JE (reprint author), US Army Inst Surg Res, Pain Management Res Area, 3698 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA. EM jen.e.nyland@gmail.com OI Averitt, Dayna/0000-0001-8345-4988 FU United States Army Medical Research and Materiel Command Combat Casualty Care Research; Clinical and Rehabilitative Medicine Research programs FX This work was supported by the United States Army Medical Research and Materiel Command Combat Casualty Care Research and the Clinical and Rehabilitative Medicine Research programs. The authors would like to acknowledge LTC Lawrence Petz, Dr. John Clifford, and Dr. Marcie Fowler for reviewing earlier versions of this manuscript and Dr. James Aden for help with statistical analyses. NR 42 TC 0 Z9 0 U1 0 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 EI 1879-1409 J9 BURNS JI Burns PD DEC PY 2015 VL 41 IS 8 BP 1796 EP 1804 DI 10.1016/j.burns.2015.09.007 PG 9 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA CZ5FK UT WOS:000367127700021 PM 26432505 ER PT J AU Fletcher, JL Cancio, LC Sinha, I Leung, KP Evan, MRA Chan, RK AF Fletcher, John L. Cancio, Leopoldo C. Sinha, Indranil Leung, Kai P. Renz, Evan M. Chan, Rodney K. TI Inability to determine tissue health is main indication of allograft use in intermediate extent burns SO BURNS LA English DT Article DE Cryopreserved allograft skin; Autograft failure; Tissue health; Depth of excision ID ENDURING FREEDOM; DEPTH ASSESSMENT; LASER-DOPPLER; SKIN ALLOGRAFTS; ALLOGENIC SKIN; CADAVERIC SKIN; IRAQI FREEDOM; BANK; EXPERIENCE; VIABILITY AB Introduction: Cutaneous allograft is commonly used in the early coverage of excised burns when autograft is unavailable. However, allograft is also applied in intermediate-extent burns (25-50%), during cases in which it is possible to autograft. In this population, there is a paucity of data on the indications for allograft use. This study explores the indications for allograft usage in moderate size burns. Methods: Under an IRB-approved protocol, patients admitted to our burn unit between March 2003 and December 2010 were identified through a review of the burn registry. Data on allograft use, total burn surface area, operation performed, operative intent, number of operations, intensive care unit length of stay, and overall length of stay were collected and analyzed. Data are presented as means standard deviations, except where noted. Results: In the study period, 146 patients received allograft during their acute hospitalization. Twenty-five percent of allograft recipients sustained intermediate-extent burns. Patients with intermediate-extent burns received allograft later in their hospitalization than those with large-extent (50-75% TBSA) burns (6.8 days vs. 3.4 days, p = 0.01). Allografted patients with intermediate-extent burns underwent more operations (10.8 vs. 6.1, p = 0.002) and had longer hospitalizations (78.3 days vs. 40.9 days, p < 0.001) than non-allografted patients, when controlled for TBSA. Clinical rationale for placement of allograft in this population included autograft failure, uncertain depth of excision, lack of autograft donor site, and wound complexity. When uncertain depth of excision was the indication, allograft was universally applied onto the face. In half of allografted intermediate-extent burn patients the inability to identify a viable recipient bed was the ultimate reason for allograft use. Conclusions: Unlike large body surface area burns, allograft skin use in intermediate-extent injury occurs later in the hospitalization and is driven by the inability to determine wound bed suitability for autograft application. Allograft application can be utilized to test recipient site viability in cases of autograft failure or uncertain depth of excision. Published by Elsevier Ltd and ISBI C1 [Fletcher, John L.; Renz, Evan M.] Brooke Army Med Ctr, Jbsa Ft Sam Houston, TX 78234 USA. [Fletcher, John L.; Cancio, Leopoldo C.; Chan, Rodney K.] US Army Inst Surg Res, Clin Div, Ft Sam Houston, TX 78234 USA. [Fletcher, John L.; Cancio, Leopoldo C.; Chan, Rodney K.] US Army Inst Surg Res, Burn Ctr, Ft Sam Houston, TX 78234 USA. [Fletcher, John L.; Leung, Kai P.; Chan, Rodney K.] US Army Inst Surg Res, Dent & Trauma Res Detachment, Ft Sam Houston, TX 78234 USA. [Sinha, Indranil] Brigham & Womens Hosp, Div Plast Surg, Boston, MA 02115 USA. RP Chan, RK (reprint author), US Army Inst Surg Res, Clin Div, 3650 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM rodney.k.chan@us.army.mil FU U.S. Army Medical Research and Material Command FX This work was funded by the U.S. Army Medical Research and Material Command. NR 49 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 EI 1879-1409 J9 BURNS JI Burns PD DEC PY 2015 VL 41 IS 8 BP 1862 EP 1867 DI 10.1016/j.burns.2015.09.006 PG 6 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA CZ5FK UT WOS:000367127700030 PM 26471053 ER PT J AU Wang, ZT Fang, SC Lavery, JE AF Wang, Ziteng Fang, Shu-Cherng Lavery, John E. TI On shape-preserving capability of cubic L-1 spline fits SO COMPUTER AIDED GEOMETRIC DESIGN LA English DT Article DE L-1 spline; Shape preservation; Approximation; Spline fit; Univariate ID GEOMETRIC-PROGRAMMING APPROACH; L-P SPLINES; MULTISCALE INTERPOLATION; BIVARIATE; CURVES AB Cubic L-1 spline fits have shown some favorable shape-preserving property for geometric data. To quantify the shape-preserving capability, we consider the basic shape of two parallel line segments in a given window. When one line segment is sufficiently longer than the other, the spline fit can preserve its linear shape in at least half of the window. We propose to use the minimum of such length difference as a shape-preserving metric because it represents the extra information that the spline fits need to preserve the shape. We analytically calculate this metric in a 3-node window for second-derivativebased, first-derivative-based and function-value-based spline fits. In a 5-node window, we compute this metric numerically. In both cases, the shape-preserving metric is rather small, which explains the observed strong shape-preserving capability of spline fits. Moreover, the function-value-based spline fits are indicated to preserve shape better than the other two types of spline fits. This study initiates a quantitative research on shape preservation of L-1 spline fits. (C) 2015 Elsevier B.V. All rights reserved. C1 [Wang, Ziteng; Fang, Shu-Cherng] N Carolina State Univ, Edward P Fitts Dept Ind & Syst Engn, Raleigh, NC 27695 USA. [Lavery, John E.] US Army, Res Off, Army Res Lab, Div Mat Sci, Res Triangle Pk, NC 27709 USA. [Lavery, John E.] US Army, Res Off, Army Res Lab, Div Comp Sci, Res Triangle Pk, NC 27709 USA. RP Wang, ZT (reprint author), N Carolina State Univ, Edward P Fitts Dept Ind & Syst Engn, Raleigh, NC 27695 USA. EM zwang23@ncsu.edu; fang@ncsu.edu; john.e.lavery4.civ@mail.mil OI Wang, Ziteng/0000-0001-7763-8959 FU US Army Research Office [W911NF-04-D-0003, W911NF-15-1-0223]; North Carolina State University Edward P. Fitts Fellowship; US NSF [DMI-0553310]; Army Research Office FX This work was generously supported by US Army Research Office Grants # W911NF-04-D-0003 and #W911NF-15-1-0223, by the North Carolina State University Edward P. Fitts Fellowship and by US NSF Grant # DMI-0553310. It is the policy of the Army Research Office that university personnel do not need to do joint work with ARO personnel in order to receive grants from the Army Research Office. NR 21 TC 0 Z9 0 U1 2 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-8396 EI 1879-2332 J9 COMPUT AIDED GEOM D JI Comput. Aided Geom. Des. PD DEC PY 2015 VL 40 BP 59 EP 75 DI 10.1016/j.cagd.2015.09.004 PG 17 WC Computer Science, Software Engineering; Mathematics, Applied SC Computer Science; Mathematics GA CZ5CY UT WOS:000367121300004 ER PT J AU DeGregorio, BA Sperry, JH Ward, MP Weatherhead, PJ AF DeGregorio, Brett A. Sperry, Jinelle H. Ward, Michael P. Weatherhead, Patrick J. TI Wait Until Dark? Daily Activity Patterns and Nest Predation by Snakes SO ETHOLOGY LA English DT Article DE automated radiotelemetry; facultative nocturnal; foraging; predatory tactics; nest cameras; nocturnal activity ID BLACK RAT SNAKES; SEASONAL-VARIATION; ELAPHE-OBSOLETA; SONGBIRD NESTS; RISK; PREY; BEHAVIOR; MORTALITY; TELEMETRY; RATSNAKES AB Predation involves costs and benefits, so predators should employ tactics that reduce their risk of injury or death and that increase their success at capturing prey. One potential way that predators could decrease risk and increase benefits is by attacking prey at night when risks may be reduced and prey more vulnerable. Because some snakes are facultatively nocturnal and prey on bird nests during the day and night, they are ideal for assessing the costs and benefits of diurnal vs. nocturnal predation. We used automated radiotelemetry and cameras to investigate predation on nesting birds by two species of snakes, one diurnal and the other facultatively nocturnal. We predicted that snakes preying on nests at night should experience less parental nest defence and capture more adults and nestlings. Rat snakes (Pantherophis obsoletus) were relatively inactive at night (23-36% activity) but nearly always preyed on nests after dark (80% of nest predations). Conversely, racers (Coluber constrictor) were exclusively diurnal and preyed on nests during the times of day they were most active. These results are consistent with rat snakes strategically using their capacity for facultative nocturnal activity to prey on nests at night. The likely benefit is reduced nest defence because birds defended their nests less vigourously at night. Consistent with nocturnal predation being safer, rat snake predation events lasted three times longer at night than during the day (26 vs. 8 min). Nocturnal nest predation did not make nests more profitable by increasing the likelihood of capturing adults or removing premature fledging of nestlings. The disconnect between rat snake activity and timing of nest predation seems most consistent with rat snakes locating prey during the day using visual cues but waiting until dark to prey on nests when predation is safer, although designing a direct test of this hypothesis will be challenging. C1 [DeGregorio, Brett A.; Sperry, Jinelle H.] US Army Corps Engineers, ERDC CERL, Champaign, IL 61826 USA. [DeGregorio, Brett A.; Sperry, Jinelle H.; Ward, Michael P.; Weatherhead, Patrick J.] Univ Illinois, Urbana, IL 61801 USA. RP DeGregorio, BA (reprint author), US Army Corps Engineers, ERDC CERL, 2902 Newmark Dr, Champaign, IL 61826 USA. EM badegregorio@gmail.com FU Construction Engineering Research Laboratory of the Engineer Research Development Center FX Funding was provided by the Construction Engineering Research Laboratory of the Engineer Research Development Center. We thank Tim Hayden for arranging funding. Special thanks to the Savannah River Ecology Laboratory for hosting us especially Tracey Tuberville and Brian Metts. We thank of all our excellent technicians including Eric Nordberg, Mary Mack Gray, Ashley Smith, Patrick Barnhart, Patrick Roberts, Phil Vogrinc, Emily Williams, Mae Cowgill, Sara Wendt, Clay Noss and Andrew Cronin. We would like to thank Scott Chiavacci for assistance in building automated radiotelemetry towers and Kirk Stodola for his assistance with analyses. We also thank Dr. Jason Norman and the Hammond Hills Animal Hospital for transmitter surgeries. Animals were collected under SC Department of Natural Resources permits # G-11-03 and 23-2012A. Animal procedures conformed to permits approved by the University of Illinois (IACUC #11054) and University of Georgia (AUP #A2011 04-007-Y2-A0). NR 44 TC 0 Z9 0 U1 8 U2 25 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0179-1613 EI 1439-0310 J9 ETHOLOGY JI Ethology PD DEC PY 2015 VL 121 IS 12 BP 1225 EP 1234 DI 10.1111/eth.12435 PG 10 WC Psychology, Biological; Behavioral Sciences; Zoology SC Psychology; Behavioral Sciences; Zoology GA CZ4WL UT WOS:000367103400009 ER PT J AU Gao, JH Zhao, Q Ren, W Swami, A Ramanathan, R Bar-Noy, A AF Gao, Jianhang Zhao, Qing Ren, Wei Swami, Ananthram Ramanathan, Ram Bar-Noy, Amotz TI Dynamic Shortest Path Algorithms for Hypergraphs SO IEEE-ACM TRANSACTIONS ON NETWORKING LA English DT Article DE Dynamic; hypergraph; hyperpath; shortest path AB A hypergraph is a set of vertices and a set of nonempty subsets of, called hyperedges. Unlike graphs, hypergraphs can capture higher-order interactions in social and communication networks that go beyond a simple union of pair-wise relationships. In this paper, we consider the shortest path problem in hypergraphs. We develop two algorithms for finding and maintaining the shortest hyperpaths in a dynamic network with both weight and topological changes. These two algorithms are the first to address the fully dynamic shortest path problem in a general hypergraph. They complement each other by partitioning the application space based on the nature of the change dynamics and the type of the hypergraph. We analyze the time complexity of the proposed algorithms and perform simulation experiments for random geometric hypergraphs, energy efficient routing in multichannel multiradio networks, and the Enron email data set. The experiment with the Enron email data set illustrates the application of the proposed algorithms in social networks for identifying the most important actor and the latent social relationship based on the closeness centrality metric. C1 [Gao, Jianhang; Zhao, Qing] Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 95618 USA. [Ren, Wei] Microsoft Corp, Redmond, WA 98052 USA. [Swami, Ananthram] Army Res Lab, Adelphi, MD 20783 USA. [Ramanathan, Ram] Raytheon BBN Technol, Cambridge, MA 02138 USA. [Bar-Noy, Amotz] CUNY, Dept Comp Sci, Brooklyn, NY 11210 USA. RP Gao, JH (reprint author), Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 95618 USA. EM jhgao@ucdavis.edu FU Army Research Laboratory Network Science CTA [W911NF-09-2-0053] FX This work was supported by the Army Research Laboratory Network Science CTA under Cooperative Agreement W911NF-09-2-0053. NR 15 TC 0 Z9 0 U1 6 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1063-6692 EI 1558-2566 J9 IEEE ACM T NETWORK JI IEEE-ACM Trans. Netw. PD DEC PY 2015 VL 23 IS 6 BP 1805 EP 1817 DI 10.1109/TNET.2014.2343914 PG 13 WC Computer Science, Hardware & Architecture; Computer Science, Theory & Methods; Engineering, Electrical & Electronic; Telecommunications SC Computer Science; Engineering; Telecommunications GA CZ4VM UT WOS:000367100900009 ER PT J AU Sampson, JN Wheeler, WA Yeager, M Panagiotou, O Wang, Z Berndt, SI Lan, Q Abnet, CC Amundadottir, LT Figueroa, JD Landi, MT Mirabello, L Savage, SA Taylor, PR De Vivo, I McGlynn, KA Purdue, MP Rajaraman, P Adami, HO Ahlbom, A Albanes, D Amary, MF An, SJ Andersson, U Andriole, G Andrulis, IL Angelucci, E Ansell, SM Arici, C Armstrong, BK Arslan, AA Austin, MA Baris, D Barkauskas, DA Bassig, BA Becker, N Benavente, Y Benhamou, S Berg, C Van Den Berg, D Bernstein, L Bertrand, KA Birmann, BM Black, A Boeing, H Boffetta, P Boutron-Ruault, MC Bracci, PM Brinton, L Brooks-Wilson, AR Bueno-De-Mesquita, HB Burdett, L Buring, J Butler, MA Cai, QY Cancel-Tassin, G Canzian, F Carrato, A Carreon, T Carta, A Chan, JKC Chang, ET Chang, GC Chang, IS Chang, J Chang-Claude, J Chen, CJ Chen, CY Chen, C Chen, CH Chen, C Chen, HY Chen, KX Chen, KY Chen, KC Chen, Y Chen, YH Chen, YS Chen, YM Chien, LH Chirlaque, MD Choi, JE Choi, YY Chow, WH Chung, CC Clavel, J Clavel-Chapelon, F Cocco, P Colt, JS Comperat, E Conde, L Connors, JM Conti, D Cortessis, VK Cotterchio, M Cozen, W Crouch, S Crous-Bou, M Cussenot, O Davis, FG Ding, T Diver, WR Dorronsoro, M Dossus, L Duell, EJ Ennas, MG Erickson, RL Feychting, M Flanagan, AM Foretova, L Fraumeni, JF Freedman, ND Freeman, LEB Fuchs, C Gago-Dominguez, M Gallinger, S Gao, YT Gapstur, SM Garcia-Closas, M Garcia-Closas, R Gascoyne, RD Gastier-Foster, J Gaudet, MM Gaziano, JM Giffen, C Giles, GG Giovannucci, E Glimelius, B Goggins, M Gokgoz, N Goldstein, AM Gorlick, R Gross, M Grubb, R Gu, J Guan, P Gunter, M Guo, H Habermann, TM Haiman, CA Halai, D Hallmans, G Hassan, M Hattinger, C He, QC He, XZ Helzlsouer, K Henderson, B Henriksson, R Hjalgrim, H Hoffman-Bolton, J Hohensee, C Holford, TR Holly, EA Hong, YC Hoover, RN Horn-Ross, PL Hosain, GMM Hosgood, HD Hsiao, CF Hu, N Hu, W Hu, ZB Huang, MS Huerta, JM Hung, JY Hutchinson, A Inskip, PD Jackson, RD Jacobs, EJ Jenab, M Jeon, HS Ji, BT Jin, GF Jin, L Johansen, C Johnson, A Jung, YJ Kaaks, R Kamineni, A Kane, E Kang, CH Karagas, MR Kelly, RS Khaw, KT Kim, C Kim, HN Kim, JH Kim, JS Kim, YH Kim, YT Kim, YC Kitahara, CM Klein, AP Klein, RJ Kogevinas, M Kohno, T Kolonel, LN Kooperberg, C Kricker, A Krogh, V Kunitoh, H Kurtz, RC Kweon, SS LaCroix, A Lawrence, C Lecanda, F Lee, VHF Li, DH Li, HX Li, JH Li, YJ Li, YQ Liao, LM Liebow, M Lightfoot, T Lim, WY Lin, CC Lin, DX Lindstrom, S Linet, MS Link, BK Liu, CW Liu, JJ Liu, L Ljungberg, B Lloreta, J Di Lollo, S Lu, D Lund, E Malats, N Mannisto, S Le Marchand, L Marina, N Masala, G Mastrangelo, G Matsuo, K Maynadie, M Mckay, J McKean-Cowdin, R Melbye, M Melin, BS Michaud, DS Mitsudomi, T Monnereau, A Montalvan, R Moore, LE Mortensen, LM Nieters, A North, KE Novak, AJ Oberg, AL Offit, K Oh, IJ Olson, SH Palli, D Pao, W Park, IK Park, JY Park, KH Patino-Garcia, A Pavanello, S Peeters, PHM Perng, RP Peters, U Petersen, GM Picci, P Pike, MC Porru, S Prescott, J Prokunina-Olsson, L Qian, B Qiao, YL Rais, M Riboli, E Riby, J Risch, HA Rizzato, C Rodabough, R Roman, E Roupret, M Ruder, AM de Sanjose, S Scelo, G Schned, A Schumacher, F Schwartz, K Schwenn, M Scotlandi, K Seow, A Serra, C Serra, M Sesso, HD Setiawan, VW Severi, G Severson, RK Shanafelt, TD Shen, HB Shen, W Shin, MH Shiraishi, K Shu, XO Siddiq, A Sierrasesumaga, L Sihoe, ADL Skibola, CF Smith, A Smith, MT Southey, MC Spinelli, JJ Staines, A Stampfer, M Stern, MC Stevens, VL Stolzenberg-Solomon, RS Su, J Su, WC Sund, M Sung, JS Sung, SW Tan, W Tang, W Tardon, A Thomas, D Thompson, CA Tinker, LF Tirabosco, R Tjonneland, A Travis, RC Trichopoulos, D Tsai, FY Tsai, YH Tucker, M Turner, J Vajdic, CM Vermeulen, RCH Villano, DJ Vineis, P Virtamo, J Visvanathan, K Wactawski-Wende, J Wang, CY Wang, CL Wang, JC Wang, JW Wei, FS Weiderpass, E Weiner, GJ Weinstein, S Wentzensen, N White, E Witzig, TE Wolpin, BM Wong, MP Wu, C Wu, GP Wu, JJ Wu, TC Wu, W Wu, XF Wu, YL Wunder, JS Xiang, YB Xu, J Xu, P Yang, PC Yang, TY Ye, YQ Yin, ZH Yokota, J Yoon, HI Yu, CJ Yu, H Yu, K Yuan, JM Zelenetz, A Zeleniuch-Jacquotte, A Zhang, XC Zhang, YW Zhao, XY Zhao, ZH Zheng, H Zheng, TZ Zheng, W Zhou, BS Zhu, M Zucca, M Boca, SM Cerhan, JR Ferri, GM Hartge, P Hsiung, CA Magnani, C Miligi, L Morton, LM Smedby, KE Teras, LR Vijai, J Wang, SS Brennan, P Caporaso, NE Hunter, DJ Kraft, P Rothman, N Silverman, DT Slager, SL Chanock, SJ Chatterjee, N AF Sampson, Joshua N. Wheeler, William A. Yeager, Meredith Panagiotou, Orestis Wang, Zhaoming Berndt, Sonja I. Lan, Qing Abnet, Christian C. Amundadottir, Laufey T. Figueroa, Jonine D. Landi, Maria Teresa Mirabello, Lisa Savage, Sharon A. Taylor, Philip R. De Vivo, Immaculata McGlynn, Katherine A. Purdue, Mark P. Rajaraman, Preetha Adami, Hans-Olov Ahlbom, Anders Albanes, Demetrius Amary, Maria Fernanda An, She-Juan Andersson, Ulrika Andriole, Gerald, Jr. Andrulis, Irene L. Angelucci, Emanuele Ansell, Stephen M. Arici, Cecilia Armstrong, Bruce K. Arslan, Alan A. Austin, Melissa A. Baris, Dalsu Barkauskas, Donald A. Bassig, Bryan A. Becker, Nikolaus Benavente, Yolanda Benhamou, Simone Berg, Christine Van Den Berg, David Bernstein, Leslie Bertrand, Kimberly A. Birmann, Brenda M. Black, Amanda Boeing, Heiner Boffetta, Paolo Boutron-Ruault, Marie-Christine Bracci, Paige M. Brinton, Louise Brooks-Wilson, Angela R. Bueno-de-Mesquita, H. Bas Burdett, Laurie Buring, Julie Butler, Mary Ann Cai, Qiuyin Cancel-Tassin, Geraldine Canzian, Federico Carrato, Alfredo Carreon, Tania Carta, Angela Chan, John K. C. Chang, Ellen T. Chang, Gee-Chen Chang, I-Shou Chang, Jiang Chang-Claude, Jenny Chen, Chien-Jen Chen, Chih-Yi Chen, Chu Chen, Chung-Hsing Chen, Constance Chen, Hongyan Chen, Kexin Chen, Kuan-Yu Chen, Kun-Chieh Chen, Ying Chen, Ying-Hsiang Chen, Yi-Song Chen, Yuh-Min Chien, Li-Hsin Chirlaque, Maria-Dolores Choi, Jin Eun Choi, Yi Young Chow, Wong-Ho Chung, Charles C. Clavel, Jacqueline Clavel-Chapelon, Franoise Cocco, Pierluigi Colt, Joanne S. Comperat, Eva Conde, Lucia Connors, Joseph M. Conti, David Cortessis, Victoria K. Cotterchio, Michelle Cozen, Wendy Crouch, Simon Crous-Bou, Marta Cussenot, Olivier Davis, Faith G. Ding, Ti Diver, W. Ryan Dorronsoro, Miren Dossus, Laure Duell, Eric J. Ennas, Maria Grazia Erickson, Ralph L. Feychting, Maria Flanagan, Adrienne M. Foretova, Lenka Fraumeni, Joseph F., Jr. Freedman, Neal D. Freeman, Laura E. Beane Fuchs, Charles Gago-Dominguez, Manuela Gallinger, Steven Gao, Yu-Tang Gapstur, Susan M. Garcia-Closas, Montserrat Garcia-Closas, Reina Gascoyne, Randy D. Gastier-Foster, Julie Gaudet, Mia M. Gaziano, J. Michael Giffen, Carol Giles, Graham G. Giovannucci, Edward Glimelius, Bengt Goggins, Michael Gokgoz, Nalan Goldstein, Alisa M. Gorlick, Richard Gross, Myron Grubb, Robert, III Gu, Jian Guan, Peng Gunter, Marc Guo, Huan Habermann, Thomas M. Haiman, Christopher A. Halai, Dina Hallmans, Goran Hassan, Manal Hattinger, Claudia He, Qincheng He, Xingzhou Helzlsouer, Kathy Henderson, Brian Henriksson, Roger Hjalgrim, Henrik Hoffman-Bolton, Judith Hohensee, Chancellor Holford, Theodore R. Holly, Elizabeth A. Hong, Yun-Chul Hoover, Robert N. Horn-Ross, Pamela L. Hosain, G. M. Monawar Hosgood, H. Dean, III Hsiao, Chin-Fu Hu, Nan Hu, Wei Hu, Zhibin Huang, Ming-Shyan Huerta, Jose-Maria Hung, Jen-Yu Hutchinson, Amy Inskip, Peter D. Jackson, Rebecca D. Jacobs, Eric J. Jenab, Mazda Jeon, Hyo-Sung Ji, Bu-Tian Jin, Guangfu Jin, Li Johansen, Christoffer Johnson, Alison Jung, Yoo Jin Kaaks, Rudolph Kamineni, Aruna Kane, Eleanor Kang, Chang Hyun Karagas, Margaret R. Kelly, Rachel S. Khaw, Kay-Tee Kim, Christopher Kim, Hee Nam Kim, Jin Hee Kim, Jun Suk Kim, Yeul Hong Kim, Young Tae Kim, Young-Chul Kitahara, Cari M. Klein, Alison P. Klein, Robert J. Kogevinas, Manolis Kohno, Takashi Kolonel, Laurence N. Kooperberg, Charles Kricker, Anne Krogh, Vittorio Kunitoh, Hideo Kurtz, Robert C. Kweon, Sun-Seog LaCroix, Andrea Lawrence, Charles Lecanda, Fernando Lee, Victor Ho Fun Li, Donghui Li, Haixin Li, Jihua Li, Yao-Jen Li, Yuqing Liao, Linda M. Liebow, Mark Lightfoot, Tracy Lim, Wei-Yen Lin, Chien-Chung Lin, Dongxin Lindstrom, Sara Linet, Martha S. Link, Brian K. Liu, Chenwei Liu, Jianjun Liu, Li Ljungberg, Boerje Lloreta, Josep Di Lollo, Simonetta Lu, Daru Lund, Eiluv Malats, Nuria Mannisto, Satu Le Marchand, Loic Marina, Neyssa Masala, Giovanna Mastrangelo, Giuseppe Matsuo, Keitaro Maynadie, Marc Mckay, James McKean-Cowdin, Roberta Melbye, Mads Melin, Beatrice S. Michaud, Dominique S. Mitsudomi, Tetsuya Monnereau, Alain Montalvan, Rebecca Moore, Lee E. Mortensen, Lotte Maxild Nieters, Alexandra North, Kari E. Novak, Anne J. Oberg, Ann L. Offit, Kenneth Oh, In-Jae Olson, Sara H. Palli, Domenico Pao, William Park, In Kyu Park, Jae Yong Park, Kyong Hwa Patino-Garcia, Ana Pavanello, Sofia Peeters, Petra H. M. Perng, Reury-Perng Peters, Ulrike Petersen, Gloria M. Picci, Piero Pike, Malcolm C. Porru, Stefano Prescott, Jennifer Prokunina-Olsson, Ludmila Qian, Biyun Qiao, You-Lin Rais, Marco Riboli, Elio Riby, Jacques Risch, Harvey A. Rizzato, Cosmeri Rodabough, Rebecca Roman, Eve Roupret, Morgan Ruder, Avima M. de Sanjose, Silvia Scelo, Ghislaine Schned, Alan Schumacher, Fredrick Schwartz, Kendra Schwenn, Molly Scotlandi, Katia Seow, Adeline Serra, Consol Serra, Massimo Sesso, Howard D. Setiawan, Veronica Wendy Severi, Gianluca Severson, Richard K. Shanafelt, Tait D. Shen, Hongbing Shen, Wei Shin, Min-Ho Shiraishi, Kouya Shu, Xiao-Ou Siddiq, Afshan Sierrasesumaga, Luis Sihoe, Alan Dart Loon Skibola, Christine F. Smith, Alex Smith, Martyn T. Southey, Melissa C. Spinelli, John J. Staines, Anthony Stampfer, Meir Stern, Marianna C. Stevens, Victoria L. Stolzenberg-Solomon, Rachael S. Su, Jian Su, Wu-Chou Sund, Malin Sung, Jae Sook Sung, Sook Whan Tan, Wen Tang, Wei Tardon, Adonina Thomas, David Thompson, Carrie A. Tinker, Lesley F. Tirabosco, Roberto Tjonneland, Anne Travis, Ruth C. Trichopoulos, Dimitrios Tsai, Fang-Yu Tsai, Ying-Huang Tucker, Margaret Turner, Jenny Vajdic, Claire M. Vermeulen, Roel C. H. Villano, Danylo J. Vineis, Paolo Virtamo, Jarmo Visvanathan, Kala Wactawski-Wende, Jean Wang, Chaoyu Wang, Chih-Liang Wang, Jiu-Cun Wang, Junwen Wei, Fusheng Weiderpass, Elisabete Weiner, George J. Weinstein, Stephanie Wentzensen, Nicolas White, Emily Witzig, Thomas E. Wolpin, Brian M. Wong, Maria Pik Wu, Chen Wu, Guoping Wu, Junjie Wu, Tangchun Wu, Wei Wu, Xifeng Wu, Yi-Long Wunder, Jay S. Xiang, Yong-Bing Xu, Jun Xu, Ping Yang, Pan-Chyr Yang, Tsung-Ying Ye, Yuanqing Yin, Zhihua Yokota, Jun Yoon, Ho-Il Yu, Chong-Jen Yu, Herbert Yu, Kai Yuan, Jian-Min Zelenetz, Andrew Zeleniuch-Jacquotte, Anne Zhang, Xu-Chao Zhang, Yawei Zhao, Xueying Zhao, Zhenhong Zheng, Hong Zheng, Tongzhang Zheng, Wei Zhou, Baosen Zhu, Meng Zucca, Mariagrazia Boca, Simina M. Cerhan, James R. Ferri, Giovanni M. Hartge, Patricia Hsiung, Chao Agnes Magnani, Corrado Miligi, Lucia Morton, Lindsay M. Smedby, Karin E. Teras, Lauren R. Vijai, Joseph Wang, Sophia S. Brennan, Paul Caporaso, Neil E. Hunter, David J. Kraft, Peter Rothman, Nathaniel Silverman, Debra T. Slager, Susan L. Chanock, Stephen J. Chatterjee, Nilanjan TI Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types SO JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE LA English DT Article ID MULTIPLE SUSCEPTIBILITY LOCI; LUNG-CANCER; FAMILIAL RISK; PANCREATIC-CANCER; SWEDEN; INDIVIDUALS; MUTATIONS; RELATIVES; LYMPHOMA; DATABASE AB Background: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites. Methods: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers. Results: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, h(l)(2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (rho = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (rho = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (rho = 0.51, SE = 0.18), and bladder and lung (rho = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures. Conclusion: Our results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation. C1 [Sampson, Joshua N.; Panagiotou, Orestis; Berndt, Sonja I.; Lan, Qing; Abnet, Christian C.; Amundadottir, Laufey T.; Mirabello, Lisa; Savage, Sharon A.; Taylor, Philip R.; McGlynn, Katherine A.; Rajaraman, Preetha; Albanes, Demetrius; Bassig, Bryan A.; Black, Amanda; Brinton, Louise; Chow, Wong-Ho; Chung, Charles C.; Colt, Joanne S.; Fraumeni, Joseph F., Jr.; Freedman, Neal D.; Freeman, Laura E. Beane; Garcia-Closas, Montserrat; Goldstein, Alisa M.; Hoover, Robert N.; Hu, Nan; Hu, Wei; Inskip, Peter D.; Ji, Bu-Tian; Kitahara, Cari M.; Liao, Linda M.; Linet, Martha S.; Moore, Lee E.; Prokunina-Olsson, Ludmila; Stolzenberg-Solomon, Rachael S.; Tang, Wei; Tucker, Margaret; Wang, Chaoyu; Weinstein, Stephanie; Wentzensen, Nicolas; Yu, Kai; Hartge, Patricia; Caporaso, Neil E.; Rothman, Nathaniel; Silverman, Debra T.; Chanock, Stephen J.; Chatterjee, Nilanjan] NCI, Div Canc Epidemiol & Genet, Bethesda, MD USA. [Wheeler, William A.; Giffen, Carol] Informat Management Serv Inc, Silver Spring, MD USA. [Yeager, Meredith; Wang, Zhaoming; Burdett, Laurie; Hutchinson, Amy; Liu, Chenwei] Natl Canc Inst, Div Canc Epidemiol & Genet, Canc Genom Res Lab, Gaithersburg, MD USA. [De Vivo, Immaculata; Bertrand, Kimberly A.; Birmann, Brenda M.; Chen, Constance; Crous-Bou, Marta; Fuchs, Charles; Giovannucci, Edward; Lindstrom, Sara; Prescott, Jennifer; Stampfer, Meir; Hunter, David J.] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA. [De Vivo, Immaculata; Bertrand, Kimberly A.; Birmann, Brenda M.; Chen, Constance; Crous-Bou, Marta; Fuchs, Charles; Giovannucci, Edward; Lindstrom, Sara; Prescott, Jennifer; Stampfer, Meir; Hunter, David J.] Harvard Univ, Sch Med, Boston, MA 02115 USA. [De Vivo, Immaculata; Bertrand, Kimberly A.; Chen, Constance; Crous-Bou, Marta; Giovannucci, Edward; Kelly, Rachel S.; Lindstrom, Sara; Prescott, Jennifer; Sesso, Howard D.; Stampfer, Meir; Trichopoulos, Dimitrios; Hunter, David J.; Kraft, Peter] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Purdue, Mark P.] Ontario Hlth Study, Toronto, ON, Canada. [Adami, Hans-Olov; Weiderpass, Elisabete] Karolinska Inst, Dept Med Epidemiol & Biostatist, Stockholm, Sweden. [Ahlbom, Anders; Feychting, Maria] Karolinska Inst, Inst Environm Med, Dept Epidemiol, S-10401 Stockholm, Sweden. [Amary, Maria Fernanda; Flanagan, Adrienne M.; Halai, Dina] UCL Canc Inst, London, England. [Amary, Maria Fernanda; Flanagan, Adrienne M.; Halai, Dina; Tirabosco, Roberto] Royal Natl Orthopaed Hosp NHS Trust, Middlesbrough, Cleveland, England. [An, She-Juan; Su, Jian; Wu, Yi-Long; Zhang, Xu-Chao] Guangdong Acad Med Sci, Guangdong Gen Hosp, Guangdong Prov Key Lab Translat Med Lung Canc, Guangdong Lung Canc Inst, Guangzhou, Guangdong, Peoples R China. [Andersson, Ulrika; Henriksson, Roger; Melin, Beatrice S.] Umea Univ, Dept Radiat Sci Oncol, Umea, Sweden. [Andriole, Gerald, Jr.; Grubb, Robert, III] Washington Univ, Sch Med, Div Urol Surg, St Louis, MO 63110 USA. [Andrulis, Irene L.; Gokgoz, Nalan; Wunder, Jay S.] Univ Toronto, Litwin Ctr Canc Genet, Toronto, ON, Canada. [Andrulis, Irene L.; Gallinger, Steven; Gokgoz, Nalan; Wunder, Jay S.] Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada. [Angelucci, Emanuele] Osped Oncol Riferimento Regionale Businco, Hematol Unit, Cagliari, Italy. [Ansell, Stephen M.; Habermann, Thomas M.; Liebow, Mark; Novak, Anne J.; Shanafelt, Tait D.; Thompson, Carrie A.; Witzig, Thomas E.] Mayo Clin, Dept Med, Rochester, MN USA. [Arici, Cecilia; Carta, Angela; Porru, Stefano] Univ Brescia, Dept Med & Surg Specialties, Radiol Sci & Publ Hlth, Brescia, Italy. [Armstrong, Bruce K.; Kricker, Anne] Univ Sydney, Sydney Sch Publ Hlth, Sydney, NSW 2006, Australia. [Arslan, Alan A.] NYU, Sch Med, Dept Obstet & Gynecol, New York, NY USA. [Arslan, Alan A.; Zelenetz, Andrew] NYU, Sch Med, Dept Environm Med, New York, NY USA. [Arslan, Alan A.; Zelenetz, Andrew] NYU, Sch Med, Dept Populat Hlth, New York, NY USA. [Arslan, Alan A.; Zelenetz, Andrew] NYU Langone, Med Ctr, Perlmutter Canc Ctr, New York, NY USA. [Austin, Melissa A.; White, Emily] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA. [Barkauskas, Donald A.; Van Den Berg, David; Conti, David; Cortessis, Victoria K.; Cozen, Wendy; Henderson, Brian; McKean-Cowdin, Roberta; Schumacher, Fredrick; Setiawan, Veronica Wendy] Univ So Calif, Dept Prevent Med, USC Keck Sch Med, Los Angeles, CA 90089 USA. [Bassig, Bryan A.; Zhang, Yawei; Zheng, Tongzhang] Yale Sch Publ Hlth, Dept Environm Hlth Sci, New Haven, CT USA. German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Baden Wurttembe, Germany. [Benavente, Yolanda; de Sanjose, Silvia] Inst Catala Oncol, IDIBELL, Unit Infect & Canc UNIC, Canc Epidemiol Res Programme, Barcelona, Spain. [Benavente, Yolanda; Chirlaque, Maria-Dolores; Dorronsoro, Miren; Lloreta, Josep; Tardon, Adonina] Ctr Invest Biomed Red Epidemiol Salud Publ CIBERE, Madrid, Spain. [Benhamou, Simone] Fdn Jean Dausset Ctr Etude Polymorphisme Humain C, Inst Natl sante & Rech med, U946, Paris, France. [Benhamou, Simone] Ctr Natl Receherche Sci, Inst Gustave Roussy, UMR8200, Villejuif, France. [Berg, Christine] Natl Canc Inst, Canc Prevent Div, Early Detect Res Grp, Bethesda, MD USA. [Van Den Berg, David; Conti, David; Cortessis, Victoria K.; Cozen, Wendy] Univ So Calif, Norris Comprehens Canc Ctr, USC Keck Sch Med, Los Angeles, CA USA. [Bernstein, Leslie; Wang, Sophia S.] Beckman Res Inst City Hope, Dept Canc Etiol, Duarte, CA USA. [Boeing, Heiner] German Inst Human Nutr, Dept Epidemiol, Potsdam, Germany. [Boffetta, Paolo] Tisch Canc Inst, Icahn Sch Med Mt Sinai, New York, NY USA. [Clavel-Chapelon, Franoise; Dossus, Laure] Ctr Res Epidemiol & Populat Hlth CESP, INSERM, Nutr,Hormones & Womens Hlth team, U1018, F-94805 Villejuif, France. [Boutron-Ruault, Marie-Christine; Clavel, Jacqueline; Clavel-Chapelon, Franoise; Dossus, Laure; Monnereau, Alain] Univ Paris 11, F-94805 Villejuif, France. [Boutron-Ruault, Marie-Christine; Clavel-Chapelon, Franoise; Dossus, Laure] Inst Gustave Roussy, F-94805 Villejuif, France. [Bracci, Paige M.; Holly, Elizabeth A.] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA. [Brooks-Wilson, Angela R.] BC Canc Agcy, Genome Sci Ctr, Vancouver, BC, Canada. [Brooks-Wilson, Angela R.] Simon Fraser Univ, Dept Biomed Physiol & Kinesiol, Burnaby, BC V5A 1S6, Canada. [Bueno-de-Mesquita, H. Bas] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands. [Bueno-de-Mesquita, H. Bas] Univ Med Ctr Utrecht, Dept Gastroenterol & Hepatol, Utrecht, Netherlands. [Buring, Julie; Gaziano, J. Michael; Sesso, Howard D.] Brigham & Womens Hosp, Dept Med, Div Prevent Med, Boston, MA 02115 USA. [Buring, Julie; Gaziano, J. Michael; Sesso, Howard D.] Harvard Univ, Sch Med, Boston, MA USA. [Buring, Julie; Gaziano, J. Michael; Sesso, Howard D.] Brigham & Womens Hosp, Dept Med, Div Aging, Boston, MD 02115 USA. [Buring, Julie; Gaziano, J. Michael; Sesso, Howard D.] Harvard Univ, Sch Med, Boston, MD USA. [Butler, Mary Ann; Carreon, Tania; Ruder, Avima M.] NIOSH, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. [Cai, Qiuyin; Shu, Xiao-Ou; Zheng, Wei] Vanderbilt Univ, Ctr Med, Dept Med, Nashville, TN 37232 USA. [Cai, Qiuyin; Shu, Xiao-Ou; Zheng, Wei] Vanderbilt Univ, Med Ctr, Vanderbilt Ingram Canc Ctr, Nashville, TN USA. [Cancel-Tassin, Geraldine; Comperat, Eva; Cussenot, Olivier; Roupret, Morgan] Ctr Rech Pathol Prostat, Paris, France. [Cancel-Tassin, Geraldine; Comperat, Eva; Cussenot, Olivier; Roupret, Morgan] Univ Paris 06, ONCOTYPE URO, GRC 5, Paris, France. [Canzian, Federico; Rizzato, Cosmeri] German Canc Res Ctr, Genom Epidemiol Grp, Heidelberg, Germany. [Carrato, Alfredo] Ramon y Cajal Univ Hosp, Madrid, Spain. [Chan, John K. C.] Queen Elizabeth Hosp, Dept Pathol, Hong Kong, Hong Kong, Peoples R China. [Chang, Ellen T.] Stanford Univ, Sch Med, Div Epidemiol, Dept Hlth Res & Policy, Stanford, CA 94305 USA. [Chang, Ellen T.] Exponent Inc, Ctr Epidemiol & Computat Biol, Hlth Sci, Menlo Pk, CA USA. [Chang, Gee-Chen] Natl Yang Ming Univ, Sch Med, Dept Med, Taipei 112, Taiwan. [Chang, Gee-Chen; Chen, Kun-Chieh; Yang, Tsung-Ying] Taichung Vet Gen Hosp, Div Chest Med, Dept Internal Med, Taichung, Taiwan. [Chang, I-Shou; Chen, Chung-Hsing; Tsai, Fang-Yu] Natl Hlth Res Inst, Natl Inst Canc Res, Zhunan, Taiwan. [Chang, Jiang; Lin, Dongxin; Tan, Wen; Wu, Chen] Chinese Acad Med Sci, Canc Inst & Hosp, Dept Etiol & Carcinogenesis, Beijing 100730, Peoples R China. [Chang, Jiang; Lin, Dongxin; Tan, Wen; Wu, Chen] Peking Union Med Coll, Beijing 100021, Peoples R China. [Chen, Chien-Jen; Li, Yao-Jen] Genom Res Ctr, Taipei, Taiwan. [Chen, Chih-Yi] Chung Shan Med Univ, Chung Shan Med Univ Hosp, Dept Surg, Div Thorac Surg,Inst Med, Taichung, Taiwan. [Chen, Chu; Hohensee, Chancellor] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA. [Chen, Chu; Giovannucci, Edward; Stampfer, Meir; Hunter, David J.] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. [Chen, Hongyan; Jin, Li; Lu, Daru; Wang, Jiu-Cun; Wu, Junjie; Zhao, Xueying; Zhao, Zhenhong] Fudan Univ, Sch Life Sci, Minist Educ, Key Lab Contemporary Anthropol, Shanghai 200433, Peoples R China. [Chen, Kexin; Li, Haixin; Zheng, Hong] Med Univ, Canc Inst & Hosp, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy,Dept Epidemiol & B, Tianjin, Peoples R China. [Chen, Kuan-Yu; Yu, Chong-Jen] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan. [Chen, Ying; Lim, Wei-Yen; Seow, Adeline] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117548, Singapore. [Chen, Ying-Hsiang; Chen, Yi-Song; Chien, Li-Hsin; Hsiao, Chin-Fu] Natl Hlth Res Inst, Inst Populat Hlth Sci, Zhunan, Taiwan. [Chen, Yuh-Min; Perng, Reury-Perng] Taipei Vet Gen Hosp, Dept Chest Med, Taipei, Taiwan. [Chen, Yuh-Min] Taipei Med Univ, Taipei Canc Ctr, Taipei, Taiwan. [Chirlaque, Maria-Dolores; Huerta, Jose-Maria] IMIB Arrixaca, Dept Epidemiol, Murcia Reg Hlth Author, Murcia, Spain. [Choi, Jin Eun; Choi, Yi Young] Kyungpook Natl Univ, Med Ctr, Canc Res Ctr, Daegu, South Korea. [Clavel, Jacqueline; Monnereau, Alain] INSERM, Ctr Res Epidemiol & Populat Hlth CESP, U1018, Environm Epidemiol Canc Grp, Villejuif, France. [Cocco, Pierluigi; Rais, Marco] Univ Cagliari, Dept Publ Hlth Clin & Mol Med, Cagliari, Italy. [Comperat, Eva; Roupret, Morgan] AP HP, Pitie Salpetriere, Dept Urol, Paris, France. [Comperat, Eva] AP HP, Pitie Salpetriere, Dept Pathol, Paris, France. [Conde, Lucia; Riby, Jacques; Skibola, Christine F.] Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35294 USA. [Conde, Lucia; Riby, Jacques; Skibola, Christine F.] Univ Alabama Birmingham, Ctr Comprehens Canc, Birmingham, AL 35294 USA. [Conde, Lucia; Riby, Jacques; Skibola, Christine F.; Smith, Martyn T.] Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA 94720 USA. [Conde, Lucia; Riby, Jacques; Skibola, Christine F.; Smith, Martyn T.] BC Canc Agcy, Ctr Lymphoid Canc, Vancouver, BC, Canada. [Connors, Joseph M.] Univ British Columbia, Dept Med, Vancouver, BC, Canada. [Cortessis, Victoria K.] Univ So Calif, Dept Obstet & Gynecol, Los Angeles, CA 90089 USA. [Cotterchio, Michelle] Canc Care Ontario, Toronto, ON, Canada. [Cotterchio, Michelle] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada. [Crouch, Simon; Kane, Eleanor; Lightfoot, Tracy; Riboli, Elio; Smith, Alex] Univ York, Dept Hlth Sci, York YO10 5DD, N Yorkshire, England. [Cussenot, Olivier] Hop Tenon, AP HP, Dept Urol, F-75970 Paris, France. [Davis, Faith G.] Univ Alberta, Sch Publ Hlth, Edmonton, AB, Canada. [Ding, Ti] Shanxi Canc Hosp, Taiyuan, Shanxi, Peoples R China. [Diver, W. Ryan; Gapstur, Susan M.; Gaudet, Mia M.; Jacobs, Eric J.; Stevens, Victoria L.] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA. [Dorronsoro, Miren] BioDonostia Res Inst, Dept Hlth, Basque Region, Spain. [Duell, Eric J.] Bellvitge Biomed Res Inst IDIBELL, Catalan Inst Oncol ICO, Canc Epidemiol Res Program, Unit Nutr Environm & Canc, Barcelona, Spain. [Ennas, Maria Grazia] Univ Cagliari, Dept Biomed Sci, Cagliari, Italy. [Erickson, Ralph L.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Foretova, Lenka] Masaryk Mem Canc Inst, Dept Canc Epidemiol & Genet, Brno, Czech Republic. [Foretova, Lenka] MF MU, Brno, Czech Republic. [Fuchs, Charles; Wolpin, Brian M.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Gago-Dominguez, Manuela] Inst Invest Sanitaria de Santiago, Serv Galego Saude SERGAS, Galician Fdn Genom Med, Genom Med Grp, Santiago De Compostela, Spain. [Gao, Yu-Tang] Shanghai Canc Inst, Dept Epidemiol, Shanghai, Peoples R China. [Garcia-Closas, Montserrat] Inst Canc Res, Div Genet & Epidemiol, London, England. [Garcia-Closas, Reina] Hosp Univ Canarias, Unidad Invest, San Cristobal la Laguna, Spain. [Gascoyne, Randy D.] Univ British Columbia, Dept Pathol, Vancouver, BC, Canada. [Gastier-Foster, Julie] Nationwide Childrens Hosp, Columbus, OH USA. [Gastier-Foster, Julie] Ohio State Univ, Dept Pathol & Pediat, Columbus, OH 43210 USA. [Gaziano, J. Michael] Vet Affairs Boston Healthcare Syst, Geriatr Res Educ & Clin Ctr, Massachusetts Vet Epidemiol Res & Informat Ctr, Boston, MA USA. [Giles, Graham G.; Severi, Gianluca] Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia. [Giles, Graham G.; Severi, Gianluca] Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Biostat & Epidemiol, Carlton, Vic 3053, Australia. [Glimelius, Bengt] Karolinska Inst, Dept Pathol & Oncol, Stockholm, Sweden. [Glimelius, Bengt] Uppsala Univ, Dept Radiol Oncol & Radiat Sci, Uppsala, Sweden. [Goggins, Michael] Sidney Kimmel Canc Ctr, Dept Oncol, Baltimore, MD USA. [Goggins, Michael] Johns Hopkins Univ, Baltimore, MD USA. [Goggins, Michael] Sidney Kimmel Canc Ctr, Dept Pathol, Baltimore, MD USA. [Goggins, Michael] Sidney Kimmel Canc Ctr, Dept Med, Baltimore, MD USA. [Gorlick, Richard] Childrens Hosp Montefiore, Albert Einstein Coll Med, Bronx, NY USA. [Gross, Myron] Univ Minnesota, Lab Med & Pathol, Minneapolis, MN USA. [Gu, Jian; Wu, Xifeng; Ye, Yuanqing] Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA. [Guan, Peng; He, Qincheng; Wactawski-Wende, Jean; Yin, Zhihua; Zhou, Baosen] China Med Univ, Sch Publ Hlth, Dept Epidemiol, Shenyang 110001, Peoples R China. [Gunter, Marc; Peeters, Petra H. M.] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England. [Guo, Huan; Wu, Tangchun] Huazhong Univ Sci & Technol, Sch Publ Hlth, Inst Occupat Med, Wuhan 430074, Peoples R China. [Guo, Huan; Wu, Tangchun] Huazhong Univ Sci & Technol, Sch Publ Hlth, Minist Educ, Key Lab Environm & Hlth, Wuhan 430074, Peoples R China. [Hallmans, Goran] Umea Univ, Dept Publ Hlth & Clin Med, Nutr Res, Umea, Sweden. [Hassan, Manal; Li, Donghui] Univ Texas MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol, Houston, TX USA. [Picci, Piero; Schwartz, Kendra; Serra, Massimo] Orthopaed Rizzoli Inst, Expt Oncol Lab, Bologna, Italy. [He, Xingzhou] Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China. [Helzlsouer, Kathy; Hoffman-Bolton, Judith; Klein, Alison P.; Visvanathan, Kala] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. [Hjalgrim, Henrik; Melbye, Mads] Statens Serum Inst, Dept Epidemiol Res, Div Hlth Surveillance & Res, DK-2300 Copenhagen, Denmark. [Holford, Theodore R.] Yale Univ, Sch Publ Hlth, Dept Biostat, New Haven, CT USA. [Hong, Yun-Chul] Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul, South Korea. [Horn-Ross, Pamela L.] Canc Prevent Inst Calif, Fremont, CA USA. [Hosain, G. M. Monawar] New Hampshire State Canc Registry, Concord, NH USA. [Hosgood, H. Dean, III] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA. [Hsiao, Chin-Fu] Natl Hlth Res Inst, Taiwan Lung Canc Tissue Specimen Informat Resourc, Zhunan, Taiwan. [Hu, Zhibin; Jin, Guangfu; Shen, Hongbing; Shen, Wei] Nanjing Med Univ, Jiangsu Collaborat Innovat Ctr Canc Personalized, Nanjing, Jiangsu, Peoples R China. [Hu, Zhibin; Jin, Guangfu; Shen, Hongbing; Shen, Wei] Nanjing Med Univ, Sch Publ Hlth, Ctr Canc, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, Nanjing, Jiangsu, Peoples R China. [Huang, Ming-Shyan; Hung, Jen-Yu] Kaohsiung Med Univ, Sch Med, Kaohsiung Med Univ Hosp, Dept Internal Med, Kaohsiung, Taiwan. [Jackson, Rebecca D.] Ohio State Univ, Div Endocrinol Diabet & Metab, Columbus, OH 43210 USA. [Jenab, Mazda; Mckay, James; Scelo, Ghislaine; Brennan, Paul] Int Agcy Res Canc, F-69372 Lyon, France. [Jeon, Hyo-Sung] Kyungpook Natl Univ, Mol Diagnost & Imaging Ctr, Daegu, South Korea. [Johansen, Christoffer] Danish Canc Soc Res Ctr, Unit Survivorship, Copenhagen, Denmark. [Johnson, Alison] Vermont Canc Registry, Burlington, VT USA. [Jung, Yoo Jin; Kang, Chang Hyun; Kim, Young Tae; Park, In Kyu] Seoul Natl Univ, Coll Med, Canc Res Inst, Dept Thorac & Cardiovasc Surg, Seoul, South Korea. [Kamineni, Aruna] Grp Hlth Res Inst, Seattle, WA USA. [Karagas, Margaret R.; Schned, Alan] Dartmouth Coll, Geisel Sch Med, Hanover, NH 03755 USA. [Kelly, Rachel S.; Vineis, Paolo] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, MRC PHE Ctr Environm & Hlth, London, England. [Khaw, Kay-Tee] Univ Cambridge, Cambridge CB2 1TN, England. [Kim, Hee Nam] Chonnam Natl Univ, Ctr Creat Biomed Scientists, Gwangju, South Korea. [Kim, Jin Hee] Seoul Natl Univ, Grad Sch Publ Hlth, Dept Environm Hlth, Seoul, South Korea. [Kim, Jun Suk] Korea Univ, Guro Hosp, Coll Med, Dept Internal Med,Div Med Oncol, Seoul, South Korea. [Kim, Yeul Hong; Park, Kyong Hwa] Korea Univ, Coll Med, Anam Hosp, Div Hematol Oncol,Dept Internal Med, Seoul 136705, South Korea. [Kim, Young-Chul; Oh, In-Jae] Chonnam Natl Univ, Hwasun Hosp, Lung & Esophageal Canc Clin, Hwasun Eup, South Korea. [Kim, Young-Chul; Oh, In-Jae] Chonnam Natl Univ, Sch Med, Dept Internal Med, Gwangju, South Korea. [Klein, Alison P.] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA. [Klein, Robert J.] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, Icahn Inst Genom & Multiscale Biol, New York, NY 10029 USA. [Kogevinas, Manolis] Ctr Res Environm Epidemiol CREAL, Barcelona, Spain. [Kogevinas, Manolis] Hosp del Mar, Municipal Inst Med Res IMIM, Barcelona, Spain. [Kogevinas, Manolis] Natl Sch Publ Hlth, Athens, Greece. [Kohno, Takashi] Natl Canc Ctr, Res Inst, Div Genome Biol, Tokyo 104, Japan. [Kolonel, Laurence N.] Canc Res Ctr Hawaii, Honolulu, HI USA. [Krogh, Vittorio] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy. [Kunitoh, Hideo] Japanese Red Cross Med Ctr, Dept Med Oncol, Tokyo, Japan. [Kurtz, Robert C.; Offit, Kenneth; Villano, Danylo J.; Virtamo, Jarmo; Zelenetz, Andrew] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10021 USA. [Kweon, Sun-Seog] Chonnam Natl Univ, Hwasun Hosp, Jeonnam Reg Canc Ctr, Hwasun Eup, South Korea. [Kweon, Sun-Seog; Shin, Min-Ho] Chonnam Natl Univ, Sch Med, Dept Prevent Med, Gwangju, South Korea. [Lawrence, Charles; Montalvan, Rebecca] Westat Corp, Rockville, MD USA. [Lecanda, Fernando; Patino-Garcia, Ana; Sierrasesumaga, Luis] Univ Navarra, Univ Navarra Clin, Dept Pediat, Pamplona, Spain. [Lee, Victor Ho Fun] Univ Hong Kong, Dept Clin Oncol, Hong Kong, Hong Kong, Peoples R China. [Liu, Jianjun] Qujing Ctr Dis Control & Prevent, Sanjiangdadao, Qujing, Peoples R China. [Li, Yuqing] Canc Prevent Inst Calif, Fremont, CA USA. [Lin, Chien-Chung] Natl Cheng Kung Univ, Cheng Kung Univ Med Coll & Hosp, Dept Internal Med, Tainan 701, Taiwan. [Weiner, George J.] Univ Iowa, Carver Coll Med, Dept Internal Med, Iowa City, IA USA. [Liu, Jianjun] Genome Inst Singapore, Human Genet, Singapore, Singapore. [Liu, Li] Huazhong Univ Sci & Technol, Ctr Canc, Union Hosp, Wuhan 430074, Peoples R China. Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, Umea, Sweden. Univ Florence, Dept Surg & Translat Med, Sect Anatomopathol, Florence, Italy. [Lund, Eiluv; Weiderpass, Elisabete] Univ Tromso, Arctic Univ Norway, Fac Hlth Sci, Dept Community Med, Tromso, Norway. Spanish Natl Canc Res Ctr CNIO, Genet & Mol Epidemiol Grp, Madrid, Spain. [Mannisto, Satu; Virtamo, Jarmo] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland. [Le Marchand, Loic; Yu, Herbert] Univ Hawaii, Ctr Canc, Canc Epidemiol Program, Honolulu, HI 96822 USA. Stanford Univ, Lucile Packard Childrens Hosp, Palo Alto, CA 94304 USA. [Masala, Giovanna; Palli, Domenico] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy. [Mastrangelo, Giuseppe; Pavanello, Sofia] Univ Padua, Dept Cardiac Thorac & Vasc Sci, Padua, Italy. [Matsuo, Keitaro] Aichi Canc Res Inst, Div Mol Med, Nagoya, Aichi, Japan. [Maynadie, Marc] Univ Burgundy, Registre Hemopathies Malignes Cote dOr, EA 4184, Dijon, France. [Maynadie, Marc] Dijon Univ Hosp, Dijon, France. [Melbye, Mads] Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA. Brown Univ, Dept Epidemiol, Div Biol & Med, Providence, RI 02912 USA. [Riboli, Elio; Siddiq, Afshan] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, London, England. [Mitsudomi, Tetsuya] Kinki Univ, Sch Med, Div Thorac Surg, Sayama, Osaka 589, Japan. [Monnereau, Alain] Inst Bergonie, Registre Hemopathies Malignes Gironde, Bordeaux, France. Aarhus Univ, Epidemiol Sect, DK-8000 Aarhus C, Denmark. Aalborg Univ Hosp, Dept Cardiol, Aalborg, Denmark. [Nieters, Alexandra] Univ Med Ctr Freiburg, Ctr Chron Immunodeficiency, Freiburg, Baden Wurttembe, Germany. [North, Kari E.] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA. [North, Kari E.] Univ N Carolina, Carolina Ctr Genome Sci, Chapel Hill, NC USA. [Oberg, Ann L.] Mayo Clin, Dept Hlth Sci Res, Div Biomed Stat & Informat, Rochester, MN USA. [Olson, Sara H.; Pike, Malcolm C.] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA. [Pao, William] Vanderbilt Univ, Med Ctr, Div Hematol & Oncol, Nashville, TN 37235 USA. [Park, Jae Yong] Kyungpook Natl Univ, Med Ctr, Lung Canc Ctr, Daegu, South Korea. [Peeters, Petra H. M.; Vermeulen, Roel C. H.] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care 194, Utrecht, Netherlands. [Peeters, Petra H. M.] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Primary Care & Publ Hlth, London, England. [Petersen, Gloria M.] Mayo Clin, Div Epidemiol, Dept Hlth Sci Res, Rochester, MN USA. [Qian, Biyun] Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan. [Qiao, You-Lin] Chinese Acad Med Sci, Canc Inst & Hosp, Dept Epidemiol, Beijing 100730, Peoples R China. [Risch, Harvey A.] Yale Univ, Sch Publ Hlth, Dept Chron Dis Epidemiol, New Haven, CT USA. [Severson, Richard K.] Wayne State Univ, Dept Family Med & Publ Hlth Sci, Detroit, MI USA. Karmanos Canc Inst, Detroit, MI USA. [Schwenn, Molly] Maine Canc Registry, Augusta, ME USA. [Serra, Consol] Univ Pompeu Fabra, Dept Ciencies Experimentals & Salut, Barcelona, Spain. [Severi, Gianluca; Vineis, Paolo] Human Genet Fdn, Turin, Italy. [Sihoe, Alan Dart Loon] Queen Mary Hosp, Div Cardiothorac Surg, Dept Surg, Hong Kong, Hong Kong, Peoples R China. Univ Melbourne, Dept Pathol, Parkville, Vic 3052, Australia. [Spinelli, John J.] BC Canc Agcy, Canc Control Res, Vancouver, BC, Canada. [Spinelli, John J.] Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC V5Z 1M9, Canada. [Staines, Anthony] Dublin City Univ, Sch Nursing & Human Sci, Dublin 9, Ireland. [Su, Wu-Chou] Natl Cheng Kung Univ, Med Coll & Hosp, Tainan 701, Taiwan. [Sund, Malin] Umea Univ, Dept Surg & Perioperat Sci, Surg, Umea, Sweden. [Sung, Jae Sook] Korea Univ, Canc Res Inst, Seoul, South Korea. [Sung, Sook Whan] Seoul St Marys Hosp, Dept Thorac & Cardiovasc Surg, Seoul, South Korea. [Tardon, Adonina] Univ Oviedo, Inst Univ Oncol, Oviedo, Spain. [Thomas, David] St Vincents Hosp, Garvan Inst Med Res, Kinghorn Canc Ctr, Darlinghurst, NSW 2010, Australia. [Tjonneland, Anne] Danish Canc Soc, Res Ctr, Copenhagen, Denmark. [Travis, Ruth C.] Univ Oxford, Canc Epidemiol Unit, Oxford, England. [Trichopoulos, Dimitrios] Acad Athens, Bur Epidemiol Res, Athens, Greece. [Trichopoulos, Dimitrios] Hellen Hlth Fdn, Athens, Greece. [Tsai, Ying-Huang] Chang Gung Mem Hosp, Dept Resp Thearpy, Chiayi, Taiwan. [Turner, Jenny] Macquarie Univ, Australian Sch Adv Med, Sydney, NSW 2109, Australia. [Turner, Jenny] Douglass Hanly Moir Pathol, Dept Histopathol, Macquarie Pk, NSW, Australia. [Vajdic, Claire M.] Univ New S Wales, Prince Wales Clin Sch, Sydney, NSW, Australia. [Vermeulen, Roel C. H.] Univ Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands. [Wactawski-Wende, Jean] SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY 14260 USA. [Wang, Chih-Liang] Chang Gung Mem Hosp, Dept Pulm & Crit Care, Taoyuan, Taiwan. [Wang, Jiu-Cun] Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai, Peoples R China. [Wang, Junwen] Univ Hong Kong, Li Ka Shing Fac Med, Ctr Genom Sci, Hong Kong, Peoples R China. [Wang, Junwen] Univ Hong Kong, Li Ka Shing Fac Med, Dept Biochem, Hong Kong, Hong Kong, Peoples R China. [Wei, Fusheng; Wu, Guoping] China Natl Environm Monitoring Ctr, Beijing, Peoples R China. [Weiderpass, Elisabete] Canc Registry Norway, Oslo, Norway. [Weiderpass, Elisabete] Folkhalsan Res Ctr, Dept Genet Epidemiol, Helsinki, Finland. [Wolpin, Brian M.] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA. [Wolpin, Brian M.] Harvard Univ, Sch Med, Boston, MA USA. [Wong, Maria Pik] Univ Hong Kong, Li Ka Shing Fac Med, Dept Pathol, Hong Kong, Hong Kong, Peoples R China. [Wu, Chen] Chinese Acad Med Sci, Canc Inst & Hosp, State Key Lab Mol Oncol, Beijing 100730, Peoples R China. [Wu, Chen] Peking Union Med Coll, Beijing 100021, Peoples R China. [Xiang, Yong-Bing] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Shanghai Canc Inst, Shanghai 200030, Peoples R China. [Xu, Jun] Univ Hong Kong, Sch Publ Hlth, Hong Kong, Hong Kong, Peoples R China. [Xu, Ping] Wuhan Iron & Steel Corp Staff Worker Hosp, Dept Oncol, Wuhan, Peoples R China. [Yang, Pan-Chyr] Natl Taiwan Univ, Coll Med, Dept Internal Med, Taipei, Taiwan. [Yokota, Jun] Inst Predict & Personalized Med Canc IMPPC, Barcelona, Spain. [Yoon, Ho-Il] Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Songnam, South Korea. [Yuan, Jian-Min] Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA. Georgetown Univ, Med Ctr, Innovat Ctr Biomed Informat, Washington, DC USA. Georgetown Univ, Med Ctr, Dept Oncol, Washington, DC 20007 USA. [Cerhan, James R.; Slager, Susan L.] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA. [Ferri, Giovanni M.] Univ Bari, Interdisciplinary Dept Med, Bari, Italy. [Magnani, Corrado] Univ Piemonte Orientale, Dept Translat Med, CPO Piemonte & Unit Med Stat & Epidemiol, Novara, Italy. [Mirabello, Lisa] Canc Prevent & Res Inst ISPO, Environm & Occupat Epidemiol Unit, Florence, Italy. [Smedby, Karin E.] Karolinska Univ Hosp, Karolinska Inst, Dept Med, Stockholm, Sweden. [Hunter, David J.] Broad Inst Harvard, Cambridge, MA USA. [Hunter, David J.] MIT, Cambridge, MA 02139 USA. [Kraft, Peter] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. RP Sampson, JN (reprint author), NCI, Biostat Branch, Div Canc Epidemiol & Genet, 9609 Med Ctr Dr,7E594, Rockville, MD 20815 USA. EM joshua.sampson@nih.gov; nilanjan.chatterjee@nih.gov RI Wang, Junwen/D-3700-2011; Qiao, You-Lin/B-4139-2012; Clavel, Jacqueline/Q-2750-2016; Hattinger, Claudia/Q-1212-2016; Beane Freeman, Laura/C-4468-2015; Kitahara, Cari/R-8267-2016; Jung, Yoojin/G-2519-2015; Kogevinas, Manolis/C-3918-2017; Weiderpass, Elisabete/M-4029-2016; Brooks-Wilson, Angela/E-9399-2012; Abnet, Christian/C-4111-2015; Purdue, Mark/C-9228-2016; Jin, Li/C-1468-2009; Savage, Sharon/B-9747-2015; de Sanjose Llongueras, Silvia/H-6339-2014; Andrulis, Irene/E-7267-2013; Gallinger, Steven/E-4575-2013; Benhamou, Simone/K-6554-2015; Krogh, Vittorio/K-2628-2016 OI Wang, Junwen/0000-0002-4432-4707; Qiao, You-Lin/0000-0001-6380-0871; Clavel, Jacqueline/0000-0002-3616-7676; Hattinger, Claudia/0000-0002-9316-5095; Beane Freeman, Laura/0000-0003-1294-4124; Joseph, Vijai/0000-0002-7933-151X; Weiderpass, Elisabete/0000-0003-2237-0128; Brooks-Wilson, Angela/0000-0003-1009-6408; Abnet, Christian/0000-0002-3008-7843; Purdue, Mark/0000-0003-1177-3108; Jin, Li/0000-0002-4546-2415; Savage, Sharon/0000-0001-6006-0740; Krogh, Vittorio/0000-0003-0122-8624 FU Intramural Research Program of the National Institutes of Health FX This study was supported by the Intramural Research Program of the National Institutes of Health. NR 35 TC 14 Z9 14 U1 7 U2 63 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0027-8874 EI 1460-2105 J9 JNCI-J NATL CANCER I JI JNCI-J. Natl. Cancer Inst. PD DEC PY 2015 VL 107 IS 12 AR djv279 DI 10.1093/jnci/djv279 PG 11 WC Oncology SC Oncology GA CZ2YN UT WOS:000366970900015 PM 26464424 ER PT J AU Deschler, DG Herr, MW Kmiecik, JR Sethi, R Bunting, G AF Deschler, Daniel G. Herr, Marc W. Kmiecik, Joann R. Sethi, Rosh Bunting, Glenn TI Tracheoesophageal Voice After Total Laryngopharyngectomy Reconstruction: Jejunum Versus Radial Forearm Free Flap SO LARYNGOSCOPE LA English DT Article DE Total laryngopharyngectomy; jejunal free flap; radial forearm free flap; tracheoesophageal voice; quality of life ID ANTEROLATERAL THIGH FLAP; PHARYNGOESOPHAGEAL RECONSTRUCTION; FUNCTIONAL OUTCOMES; CERVICAL ESOPHAGUS; TOTAL LARYNGECTOMY; SWALLOWING OUTCOMES; RESTORATION; SPEECH; EXPERIENCE; PROSTHESIS AB Objective/Hypothesis: Tracheoesophageal (TE) voice restoration after laryngopharyngectomy with jejunal (Jej) flap and radial forearm flap (RFF) reconstruction has been successfully completed and studied for both techniques, but no direct comparisons exist. We undertook this study to directly compare TE voice in patients with total laryngopharyngectomy (TLP) reconstruction using the Jej and the RFF in a comprehensive and rigorous manner. Study Design: Retrospective cohort study. Methods: Forty patients after total laryngectomy or TLP were grouped by pharyngeal closure method: 18 primary closure (STL), 10 jejunal flap (TLP-Jej), and 12 radial forearm flap (TLP-RFF). Voice recordings underwent objective acoustic analysis and blinded subjective assessment by trained and naive listeners. Quality-of-life (QOL) assessments were obtained in all subjects using general health, disease-specific, and voice-specific survey tools. Results: All studies groups had similar demographics. Acoustic analysis demonstrated no differences in fundamental frequency or intensity levels. Subjective assessment demonstrated statistically significant inferior voice function of the reconstructed patients (TLP-Jej and TLP-RFF) compared to STL subjects for nearly all parameters tested by both naive and trained listeners. No differences were noted between TLP-Jej and TLP-RFF subjects for any of the parameters evaluated. Overall, trained listeners assessed TE voice more favorably compared to naive listeners in a significant manner. The three QOL surveys revealed no significant differences between TLP-Jej and TLP-RFF subjects. Conclusion: Tracheoesophageal voice in TLP-Jej and TLP-RFF subjects was equivalent but inferior to STL subjects. Reconstructed subjects had no differences in general, disease-specific, and voice-specific quality of life. C1 [Deschler, Daniel G.; Sethi, Rosh; Bunting, Glenn] Harvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Dept Otolaryngol Head & Neck Surg, Boston, MA 02114 USA. [Herr, Marc W.] Brooke Army Med Ctr, Dept Otolaryngol Head & Neck Surg, San Antonio, TX USA. [Kmiecik, Joann R.] Cleveland Clin, Head & Neck Inst, Cleveland, OH 44106 USA. RP Deschler, DG (reprint author), Harvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Dept Otolaryngol Head & Neck Surg,Acad Affairs, 243 Charles St, Boston, MA 02114 USA. EM daniel_deschler@meei.harvard.edu FU Synthes Grant from The American Head and Neck Society FX Partial financial support for this study was provided by the Synthes Grant awarded from The American Head and Neck Society. The authors have no additional funding, financial relationships, or conflicts of interest to disclose. NR 50 TC 1 Z9 1 U1 1 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0023-852X EI 1531-4995 J9 LARYNGOSCOPE JI Laryngoscope PD DEC PY 2015 VL 125 IS 12 BP 2715 EP 2721 DI 10.1002/lary.25404 PG 7 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA CZ6CC UT WOS:000367187700027 PM 26198802 ER PT J AU Certal, V Silva, H Carvalho, C Costa-Pereira, A Azevedo, I Winck, J Capasso, R Camacho, M AF Certal, Victor Silva, Helder Carvalho, Carlos Costa-Pereira, Altamiro Azevedo, Ines Winck, Joao Capasso, Robson Camacho, Macario TI Model for Prediction of Pediatric OSA: Proposal for a Clinical Decision Rule SO LARYNGOSCOPE LA English DT Article DE Clinical decision rule; diagnosis; pediatric OSA ID OBSTRUCTIVE SLEEP-APNEA; QUESTIONNAIRE; METAANALYSIS; RELIABILITY; DISORDERS; DIAGNOSIS; VALIDITY; CHILDREN AB Objectives/Hypothesis: Obstructive sleep apnea (OSA) is a syndrome frequently diagnosed in children; however, it lacks optimal diagnostic methods. This study aimed to provide a clinical decision rule for predicting pediatric OSA using commonly available clinical information. Study Design: A prospective cohort study. Methods: Children between the ages of 3 to 6 years-old, referred for an otorhinolaryngology consultation due to clinical suspicion of OSA, were recruited from January to June 2014. At baseline age, weight, height, gender, body mass index, Pediatric Sleep Questionnaire (PSQ) scores, tonsil size, and oxygen desaturation index (ODI) were assessed. A logistic regression modeling was used with backward stepwise elimination to develop a prediction model. Results: Sixty-seven children were included with a mean age of 4.51 years. Of the 67 children included in this study, 25 (37.3%) subjects were diagnosed with pediatric OSA. Significant predictors of pediatric OSA in the final model (odds ratio, 95% confidence interval) included PSQ score (5.12; 3.3-6.5), ODI (1.34; 1.0-1.79) and tonsil size (6.7; 3.22-9.75). The final decision rule had a sensitivity of 88% and a specificity of 86%. The area under the receiver operating characteristic curve was 0.897. Conclusion: The proposed clinical decision rule, based on three readily available variables, is a promising discriminating instrument for prediction of OSA among children between 3 and 6 years. C1 [Costa-Pereira, Altamiro] Univ Porto, Ctr Res Hlth Technol & Informat Syst, P-4100 Oporto, Portugal. [Azevedo, Ines] Univ Porto, Dept Pediat, Fac Med, P-4100 Oporto, Portugal. [Winck, Joao] Univ Porto, Fac Med, Dept Pulmonol, P-4100 Oporto, Portugal. [Certal, Victor] Hosp CUF, Sleep Med Ctr, Dept Otorhinolaryngol, Oporto, Portugal. [Certal, Victor; Silva, Helder; Carvalho, Carlos] Hosp Sao Sebastiao, Dept Otorrinolaringol, P-4520 Sta Maria Da Feira, Portugal. [Capasso, Robson] Stanford Hosp & Clin, Div Sleep Surg, Dept Otolaryngol Head & Neck Surg, Stanford, CA USA. [Camacho, Macario] Tripler Army Med Ctr, Div Sleep Surg & Med, Dept Otolaryngol, Honolulu, HI 96859 USA. RP Certal, V (reprint author), Hosp Sao Sebastiao, Dept Otorrinolaringol, Rua Dr Candido Pinho, P-4520 Sta Maria Da Feira, Portugal. EM victorcertal@gmail.com RI FMUP, CINTESIS/C-6631-2014; Costa-Pereira, Altamiro/I-5987-2012; OI FMUP, CINTESIS/0000-0001-7248-2086; Costa-Pereira, Altamiro/0000-0001-8467-6398; Certal, Victor/0000-0002-1904-9504; Winck, Joao/0000-0002-4774-8206; Camacho, Macario/0000-0001-9200-9085 NR 16 TC 1 Z9 1 U1 7 U2 12 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0023-852X EI 1531-4995 J9 LARYNGOSCOPE JI Laryngoscope PD DEC PY 2015 VL 125 IS 12 BP 2823 EP 2827 DI 10.1002/lary.25438 PG 5 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA CZ6CC UT WOS:000367187700045 PM 26154921 ER PT J AU Zhou, L Kammerer, C Giri, A Cho, K Sohn, Y AF Zhou, Le Kammerer, Catherine Giri, Anit Cho, Kyu Sohn, Yongho TI Microstructural Development and Ternary Interdiffusion in Ni-Mn-Ga Alloys SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE LA English DT Article ID SHAPE-MEMORY ALLOYS; FIELD-INDUCED STRAIN; MARTENSITE STABILIZATION; MULTICOMPONENT DIFFUSION; COMPOSITION DEPENDENCE; IRREVERSIBLE-PROCESSES; RECIPROCAL RELATIONS; CRYSTAL-STRUCTURE; HEUSLER ALLOYS; NIMNGA ALLOYS AB NiMnGa alloys functioning as either ferromagnetic shape memory alloys or magnetocaloric materials have both practical applications and fundamental research value. In this study, solid-to-solid diffusion couple experiments were carried out to investigate the phase equilibria, microstructural development, and interdiffusion behavior in Ni-Mn-Ga ternary alloys. Selected diffusion couples between pure Ni, Ni25Mn75 and four ternary off-stoichiometric NiMnGa alloys (i.e., Ni52Mn18Ga30, Ni46Mn30Ga24, Ni52Mn30Ga18, Ni58Mn18Ga24) were assembled and annealed at 1073 K, 1123 K, and 1173 K (800 degrees C, 850 degrees C, and 900 degrees C) for 480, 240, and 120 hours, respectively. At these high temperatures, the beta NiMnGa phase has a B2 crystal structure. The microstructure of the interdiffusion zone was examined by scanning electron microscopy and transmission electron microscopy. Concentration profiles across the interdiffusion zone were determined by electron probe micro analysis. Solubility values obtained for various phases were mostly consistent with the existing isothermal phase diagrams, but the phase boundary of the gamma(Mn) + beta two-phase region was slightly modified. In addition, equilibrium compositions for the gamma(Ni) and alpha' phases at 1173 K (900 degrees C) were also determined for the respective two-phase region. Both austenitic and martensitic phases were found at room temperature in each diffusion couple with a clear boundary. The compositions at the interfaces corresponded close to valence electron concentration (e/a) of 7.6, but trended to lower values when Mn increased to more than 35 at. pct. Average effective interdiffusion coefficients for the b phase over different compositional ranges were determined and reported in the light of temperature-dependence. Ternary interdiffusion coefficients were also determined and examined to assess the ternary diffusional interactions among Ni, Mn, and Ga. Ni was observed to interdiffuse the fastest, followed by Mn then Ga. Interdiffusion flux of Ni also has strong influences on the interdiffusion of Mn and Ga with large and negative cross interdiffusion coefficients, (D) over tilde (Ga)(MnNi) and (D) over tilde (Mn)(GaNi). The (D) over tilde (Ga)(NiNi) and (D) over tilde (Ga)(MnMn) ternary interdiffusion coefficients exhibited minimum values near 52 at. pct Ni concentration. (C) The Minerals, Metals & Materials Society and ASM International 2015 C1 [Zhou, Le; Kammerer, Catherine; Sohn, Yongho] Univ Cent Florida, Dept Mat Sci & Engn, Orlando, FL 32816 USA. [Zhou, Le; Kammerer, Catherine; Sohn, Yongho] Univ Cent Florida, Adv Mat Proc & Anal Ctr, Orlando, FL 32816 USA. [Giri, Anit] US Army Res Lab, TKC Global, Herndon, VA 20171 USA. [Cho, Kyu] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Sohn, Y (reprint author), Univ Cent Florida, Dept Mat Sci & Engn, Orlando, FL 32816 USA. EM Yongho.Sohn@ucf.edu RI Sohn, Yongho/A-8517-2010; Zhou, Le/H-9531-2016 OI Sohn, Yongho/0000-0003-3723-4743; Zhou, Le/0000-0001-8327-6667 FU U.S. Army Research Laboratory between University of Central Florida [W911NF-11-2-0020]; U.S. Army Research Laboratory FX This research was sponsored by the U.S. Army Research Laboratory through cooperative agreement #W911NF-11-2-0020 between University of Central Florida and the U.S. Army Research Laboratory. The views, opinions, and conclusions made in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the U.S. Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. The authors would also like to thank Mr. Timothy Delahanty at Pittsburgh Materials Technology, Pittsburgh, Pennsylvania, USA, for preparation of the alloys, and Mr. Thomas Beasley at Florida International University, Miami, Florida, USA, for the assistance with EMPA operation. NR 45 TC 1 Z9 1 U1 9 U2 27 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1073-5623 EI 1543-1940 J9 METALL MATER TRANS A JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci. PD DEC PY 2015 VL 46A IS 12 BP 5572 EP 5587 DI 10.1007/s11661-015-3123-x PG 16 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA CZ1YU UT WOS:000366902900012 ER PT J AU Douglas, CE Kulesh, DA Jaissle, JG Minogue, TD AF Douglas, Christina E. Kulesh, David A. Jaissle, James G. Minogue, Timothy D. TI Real-time reverse transcriptase polymerase chain reaction assays for Middle East Respiratory Syndrome SO MOLECULAR AND CELLULAR PROBES LA English DT Article DE RT-qPCR; MERS; Coronavirus; TaqMan (R)-MGB ID SYNDROME CORONAVIRUS; INFECTIONS AB Here we designed and tested two highly specific quantitative TaqMan (R)-MGB-based reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) assays for Middle East Respiratory Syndrome (MERS). The primers and probes for these assays were evaluated and found to have a limit of detection CLOD) of 0.005 plaque-forming units/PCR (pfu/PCR). Published by Elsevier Ltd. C1 [Douglas, Christina E.; Kulesh, David A.; Jaissle, James G.; Minogue, Timothy D.] US Army Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. RP Minogue, TD (reprint author), US Army Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. EM timothy.d.minogue.civ@mail.mil FU Defense Threat Reduction Agency (DTRA) [CB3901] FX This study was supported by the Defense Threat Reduction Agency (DTRA) project ID no. CB3901. The opinions, interpretations, conclusions, and recommendations in this report are those of the authors and are not necessarily endorsed by the U.S. Army. NR 6 TC 1 Z9 1 U1 1 U2 3 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0890-8508 J9 MOL CELL PROBE JI Mol. Cell. Probes PD DEC PY 2015 VL 29 IS 6 BP 511 EP 513 DI 10.1016/j.mcp.2015.09.001 PG 3 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Cell Biology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Cell Biology GA CZ6LD UT WOS:000367211900027 PM 26365228 ER PT J AU Pan, H Piermartiri, TCB Chen, J McDonough, J Oppel, C Driwech, W Winter, K McFarland, E Black, K Figueiredo, T Grunberg, N Marini, AM AF Pan, Hongna Piermartiri, Tetsade C. B. Chen, Jun McDonough, John Oppel, Craig Driwech, Wafae Winter, Kristin McFarland, Emylee Black, Katelyn Figueiredo, Taiza Grunberg, Neil Marini, Ann M. TI Repeated systemic administration of the nutraceutical alpha-linolenic acid exerts neuroprotective efficacy, an antidepressant effect and improves cognitive performance when given after soman exposure SO NEUROTOXICOLOGY LA English DT Article DE Rat; Alpha-linolenic acid; Soman; Behavior; Neuroprotection; Neurodegeneration; Passive avoidance; Porsolt forced swim test ID POSTTRAUMATIC-STRESS-DISORDER; SUBWAY SARIN ATTACK; TRAUMATIC BRAIN-INJURY; FORCED-SWIMMING TEST; PASSIVE-AVOIDANCE; INDUCED SEIZURES; TOKYO SUBWAY; LONG-TERM; NEUROTROPHIC FACTOR; INDUCED NEUROPATHOLOGY AB Exposure to nerve agents results in severe seizures or status epilepticus caused by the inhibition of acetylcholinesterase, a critical enzyme that breaks down acetylcholine to terminate neurotransmission. Prolonged seizures cause brain damage and can lead to long-term consequences. Current counter-measures are only modestly effective against the brain damage supporting interest in the evaluation of new and efficacious therapies. The nutraceutical alpha-linolenic acid (LIN) is an essential omega-3 polyunsaturated fatty acid that has a wide safety margin. Previous work showed that a single intravenous injection of alpha-linolenic acid (500 nmol/kg) administered before or after soman significantly protected against soman-induced brain damage when analyzed 24 h after exposure. Here, we show that administration of three intravenous injections of alpha-linolenic acid over a 7 day period after soman significantly improved motor performance on the rotarod, enhanced memory retention, exerted an anti-depressant-like activity and increased animal survival. This dosing schedule significantly reduced soman-induced neuronal degeneration in four major vulnerable brain regions up to 21 days. Taken together, alpha-linolenic acid reduces the profound behavioral deficits induced by soman possibly by decreasing neuronal cell death, and increases animal survival. Published by Elsevier Inc. C1 [Pan, Hongna; Chen, Jun; Marini, Ann M.] Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. [Piermartiri, Tetsade C. B.] Uniformed Serv Univ Hlth Sci, Mol & Cellular Biol Grad Sch Program, Bethesda, MD 20814 USA. [Figueiredo, Taiza] Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA. [Grunberg, Neil] Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Bethesda, MD 20814 USA. [Chen, Jun; McDonough, John; Oppel, Craig; Driwech, Wafae; Winter, Kristin; McFarland, Emylee; Black, Katelyn] US Army, Med Res Inst Chem Def, Div Res, Pharmacol Branch, Aberdeen Proving Ground, MD 21010 USA. RP Marini, AM (reprint author), Uniformed Serv Univ Hlth Sci, Dept Neurol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM Ann.marini@usuhs.edu OI Piermartiri, Tetsade/0000-0002-9773-6983 FU Defense Threat Reduction Agency-Joint Science and Technology Office, Medical ST Division [CBM.NEURO.01.10.US.012, CBM.NEURO.01.10. US.019] FX This work was supported by the Defense Threat Reduction Agency-Joint Science and Technology Office, Medical S&T Division (Grant Nos. CBM.NEURO.01.10.US.012 and CBM.NEURO.01.10. US.019) to A.M.M. NR 123 TC 1 Z9 1 U1 1 U2 10 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0161-813X EI 1872-9711 J9 NEUROTOXICOLOGY JI Neurotoxicology PD DEC PY 2015 VL 51 BP 38 EP 50 DI 10.1016/j.neuro.2015.09.006 PG 13 WC Neurosciences; Pharmacology & Pharmacy; Toxicology SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology GA CZ2SC UT WOS:000366953900005 PM 26386148 ER PT J AU Wojnicki, FHE Johnson, DS Charny, G Corwin, RLW AF Wojnicki, F. H. E. Johnson, D. S. Charny, G. Corwin, R. L. W. TI Development of bingeing in rats altered by a small operant requirement SO PHYSIOLOGY & BEHAVIOR LA English DT Article DE Binge eating; Dietary fat; Operant behavior; Rats; Shortening ID LIMITED ACCESS CONDITIONS; FOOD-INTAKE; SCHEDULE; FAT; BACLOFEN; BEHAVIOR; SIZE; REINFORCEMENT; PERFORMANCE; RACLOPRIDE AB Previous studies have shown that providing an optional food for a brief period of time to non-food deprived rats on an intermittent basis in the home cage engenders significantly more intake (binge-type behavior) than when the optional food is provided for a brief period on a daily basis. Experiment I examined the effects of placing a small operant response requirement on access to an optional food (vegetable shortening) on the establishment of binge-type behavior. Experiment 2 examined the effects of different schedules of reinforcement, a period of abstinence from shortening, and 24 h of food deprivation on established binge-type behavior. In Experiment 1 the group of rats with 30-min access to shortening on an intermittent basis in their home cages (IC) consumed significantly more shortening than the group with 30-min daily access in the home cage (DC). The group with 30-min intermittent access in an operant chamber (10 group) earned significantly more reinforcers than the group with 30-min daily access in an operant chamber (DO). In Experiment 2, the 10 group earned significantly more reinforcers than the DO group regardless of the response cost, the period of shortening abstinence, and overnight food deprivation. These results demonstrate that while intermittent access generates binge-type eating, the size of the binge (intake) can be altered by different contingency arrangements. (C) 2015 Elsevier Inc. All rights reserved. C1 [Wojnicki, F. H. E.; Corwin, R. L. W.] Penn State Univ, Chandlee Lab 110, Nutr Sci, University Pk, PA 16801 USA. [Johnson, D. S.] Univ Penn, Sch Med, Dept Pathol & Lab Med, Virol, Philadelphia, PA 19104 USA. [Charny, G.] Womack Army Med Ctr, Dept Emergency Med, Ft Bragg, NC 28310 USA. RP Corwin, RLW (reprint author), Penn State Univ, Coll Hlth & Human Dev, Dept Nutr Sci, Chandlee Lab 110, University Pk, PA 16801 USA. EM rxc13@psu.edu FU [MH67943] FX Support for this study by MH67943 (RLC). NR 40 TC 1 Z9 1 U1 1 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0031-9384 J9 PHYSIOL BEHAV JI Physiol. Behav. PD DEC 1 PY 2015 VL 152 BP 112 EP 118 DI 10.1016/j.physbeh.2015.09.009 PN A PG 7 WC Psychology, Biological; Behavioral Sciences SC Psychology; Behavioral Sciences GA CZ2RZ UT WOS:000366953600016 PM 26375821 ER PT J AU McAninch, IM Palmese, GR Lenhart, JL La Scala, JJ AF McAninch, Ian M. Palmese, Giuseppe R. Lenhart, Joseph L. La Scala, John J. TI DMA Testing of Epoxy Resins: The Importance of Dimensions SO POLYMER ENGINEERING AND SCIENCE LA English DT Article ID DYNAMIC-MECHANICAL ANALYSIS; POLY(ETHER ETHER KETONE); ANHYDRIDE-CURED EPOXY; THERMAL-PROPERTIES; POLYMER NETWORKS; CROSS-LINKING; MODIFIED BISMALEIMIDE; DIELECTRIC-PROPERTIES; FRACTURE-TOUGHNESS; CARBON NANOTUBES AB Dynamic mechanical analysis is commonly used to characterize thermoset polymers at temperatures ranging from well below to well above their glass transition temperatures. Many sample fixtures are available; however, the best clamp and best sample dimensions for a given material are not often readily apparent. Five different epoxy amine networks with glass transitions spanning over 100 degrees C were characterized on three-point bending, dual cantilever, and single cantilever clamps with both constant thickness and constant span-to-thickness. Glassy modulus values were accurately measured on all clamps provided span-to-thickness ratios >10 were maintained. Thermal expansion and decreasing sample stiffness with increasing temperature greatly affect measurements in the rubbery region resulting in single cantilever clamps being best suited to measure rubbery data. (C) 2015 Society of Plastics Engineers C1 [McAninch, Ian M.; Lenhart, Joseph L.; La Scala, John J.] US Army Res Lab, RDRL WMM C, Aberdeen Proving Ground, MD 21005 USA. [McAninch, Ian M.; Palmese, Giuseppe R.] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. RP La Scala, JJ (reprint author), US Army Res Lab, RDRL WMM C, Aberdeen Proving Ground, MD 21005 USA. EM john.j.lascala.civ@mail.mil OI McAninch, Ian/0000-0002-9190-2936 NR 100 TC 6 Z9 6 U1 11 U2 42 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0032-3888 EI 1548-2634 J9 POLYM ENG SCI JI Polym. Eng. Sci. PD DEC PY 2015 VL 55 IS 12 BP 2761 EP 2774 DI 10.1002/pen.24167 PG 14 WC Engineering, Chemical; Polymer Science SC Engineering; Polymer Science GA CZ1BA UT WOS:000366839500010 ER PT J AU Cai, HQ Dumais, RE AF Cai, Huaqing Dumais, Robert E., Jr. TI Object-Based Evaluation of a Numerical Weather Prediction Model's Performance through Forecast Storm Characteristic Analysis SO WEATHER AND FORECASTING LA English DT Article ID PRECIPITATION FORECASTS; PART I; VERIFICATION; SYSTEMS; PREDICTABILITY; METHODOLOGY; TRACKING AB Traditional pixel-versus-pixel forecast evaluation scores such as the critical success index (CSI) provide a simple way to compare the performances of different forecasts; however, they offer little information on how to improve a particular forecast. This paper strives to demonstrate what additional information an object-based forecast evaluation tool such as the Method for Object-Based Diagnostic Evaluation (MODE) can provide in terms of assessing numerical weather prediction models' convective storm forecasts. Forecast storm attributes evaluated by MODE in this paper include storm size, intensity, orientation, aspect ratio, complexity, and number of storms. Three weeks of the High Resolution Rapid Refresh (HRRR) model's precipitation forecasts during the summer of 2010 over the eastern two-thirds of the contiguous United States were evaluated as an example to demonstrate the methodology. It is found that the HRRR model was able to forecast convective storm characteristics rather well either as a function of time of day or as a function of storm size, although significant bias does exist, especially in terms of storm number and storm size. Another interesting finding is that the model's ability of forecasting new storm initiation varies substantially by regions, probably as a result of its different skills in forecasting convection driven by different forcing mechanisms (i.e., diurnal heating vs synoptic-scale frontal systems). C1 [Cai, Huaqing] Natl Ctr Atmospher Res, Boulder, CO 80307 USA. [Dumais, Robert E., Jr.] US Army, Res Lab, White Sands Missile Range, NM 88002 USA. RP Cai, HQ (reprint author), US Army, Res Lab, White Sands Missile Range, NM 88002 USA. EM huaqing.cai.civ@mail.mil FU Federal Aviation Administration (FAA); U.S. Army Research Laboratory FX This research is in response to requirements and funding by the Federal Aviation Administration (FAA). HC is also partially supported by the U.S. Army Research Laboratory. The views expressed are those of the authors and do not necessarily represent the official policy or position of the FAA or the U.S. Army. NR 34 TC 2 Z9 2 U1 1 U2 6 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0882-8156 EI 1520-0434 J9 WEATHER FORECAST JI Weather Forecast. PD DEC PY 2015 VL 30 IS 6 BP 1451 EP 1468 DI 10.1175/WAF-D-15-0008.1 PG 18 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA CZ3DX UT WOS:000366985700001 ER PT J AU Napolitano, M AF Napolitano, Marc TI 'Utterly Baffled and Beaten, What Was the Lonely and Brokenhearted Man to Do?': Narration, Ambiguity, and Sympathy in Stanley Kubrick's Barry Lyndon SO ADAPTATION-THE JOURNAL OF LITERATURE ON SCREEN STUDIES LA English DT Article DE Stanley Kubrick; William Makepeace Thackeray; Barry Lyndon; adaptation; unreliable narrator; narration AB Stanley Kubrick's Barry Lyndon is regarded as one of the most aesthetically beautiful films of all time, though its painterly cinematography is counterbalanced by the harshness, coldness, and melancholy of the onscreen narrative. This divergence is evocative of traditional narratological debates over the reliability of narrators: a narrator's unreliability is typically measured by his concurrence or divergence with the implied author. Such debates are essential to any discussion of Kubrick's Barry Lyndon and its literary source, William Makepeace Thackeray's The Luck of Barry Lyndon: while Thackeray's Barry epitomises the traits of the unreliable narrator, Kubrick's third-person narrator has proved a controversial figure, with numerous scholars debating his reliability based on his concurrence (or conflict) with the onscreen narrative. This paper argues that the fundamental reliability of Kubrick's narrator is not simply based on his relationship with the visual narrative, but also on his serving as a manifestation of the voice of the novel's implied author. This convergence between the authorial voices of Kubrick and Thackeray through the voice-over narration ultimately supports the onscreen narrator's assessment of Barry's rise and fall but simultaneously promotes sympathy for both incarnations of Redmond Barry. C1 [Napolitano, Marc] US Mil Acad, Dept English & Philosophy, West Point, NY 10996 USA. RP Napolitano, M (reprint author), US Mil Acad, Dept English & Philosophy, West Point, NY 10996 USA. EM marc.napolitano@usma.edu NR 24 TC 0 Z9 0 U1 0 U2 1 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1755-0637 EI 1755-0645 J9 ADAPTATION-UK JI Adaptation PD DEC PY 2015 VL 8 IS 3 SI SI BP 330 EP 344 DI 10.1093/adaptation/apv005 PG 15 WC Film, Radio, Television; Literature SC Film, Radio & Television; Literature GA CY4HU UT WOS:000366370000005 ER PT J AU Velasco, JM Valderama, MT Lopez, MN Chua, D Latog, R Roque, V Corpuz, J Klungthong, C Rodpradit, P Hussem, K Poolpanichupatam, Y Macareo, L Fernandez, S Yoon, IK AF Velasco, John Mark Valderama, Maria Theresa Lopez, Maria Nila Chua, Domingo, Jr. Latog, Rene, II Roque, Vito, Jr. Corpuz, June Klungthong, Chonticha Rodpradit, Prinyada Hussem, Kittinun Poolpanichupatam, Yongyuth Macareo, Louis Fernandez, Stefan Yoon, In-Kyu TI Chikungunya Virus Infections among Patients with Dengue-Like Illness at a Tertiary Care Hospital in the Philippines, 2012-2013 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID SOUTHEAST-ASIA; REUNION ISLAND; CONCURRENT OUTBREAKS; VIRAL DISEASES; FEVER; EPIDEMIC; CHILDREN; PACIFIC; TRANSMISSION; REEMERGENCE AB Chikungunya virus (CHIKV) often co-circulates with dengue virus (DENV). A cross-sectional surveillance study was conducted at a tertiary hospital in Manila, Philippines, to describe the prevalence and characteristics of DENY and CHIKV infections among patients seeking care for dengue-like illness. Acute blood samples from patients 6 months of age clinically diagnosed with dengue from November 2012 to December 2013 underwent reverse transcription polymerase chain reaction (RT-PCR) to detect DENY and CHIKV RNA. A total of 118 patients with clinically diagnosed dengue (age range = 1-89 years, mean = 22 years; male-to-female ratio = 1.51) were tested by DENY RT-PCR; 40 (34%) were DENY PCR-positive (age range = 1-45 years, mean = 17 years). All DENY serotypes were detected: 11 (28%) DENY-1, 6 (15%) DENV-2, 6 (15%) DENV-3, and 17 (42%) DENV-4. Of 112 patients clinically diagnosed with dengue and tested by CHIKV RT-PCR, 11 (10%) were CHIKV PCR-positive (age range = 2-47 years, mean = 20.3 years). No coinfections were detected. Presenting signs/symptoms did not differ between DENY- and CHIKV-positive cases. Sequencing of envelope 1 gene from two CHIKV PCR-positive samples showed Asian genotype. This study highlights the potential for misdiagnosis of medically attended CHIKV infections as DENY infection and the difficulty in clinically differentiating dengue and chikungunya based on presenting signs/symptoms alone. This underscores the necessity for diagnostic laboratory tests to distinguish CHIKV infections in the background of actively co-circulating DENY. C1 [Velasco, John Mark; Klungthong, Chonticha; Rodpradit, Prinyada; Hussem, Kittinun; Poolpanichupatam, Yongyuth; Macareo, Louis; Fernandez, Stefan; Yoon, In-Kyu] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Lopez, Maria Nila] Armed Forces Philippines Med Serv Sch, Quezon City, Philippines. Armed Forces Philippines Med Ctr, Dept Res & Training, Quezon City, Philippines. Dept Hlth, Epidemiol Bur, Manila, Philippines. [Velasco, John Mark; Valderama, Maria Theresa] Armed Forces Philippines Med Ctr, V Luna Gen Hosp, Philippines AFRIMS Virol Res Unit, Quezon City, Philippines. [Chua, Domingo, Jr.; Latog, Rene, II] Armed Forces Philippines Med Ctr, V Luna Gen Hosp, Dept Res & Training, Quezon City, Philippines. [Roque, Vito, Jr.; Corpuz, June] Dept Hlth, Epidemiol Bur, Manila, Philippines. RP Velasco, JM (reprint author), Armed Forces Res Inst Med Sci, Dept Virol, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM velascojm@afrims.org; valderamamg.ca@afrims.org; manila28@yahoo.com.ph; dachuajr@gmail.com; latogreneii@yahoo.com; vitogroquejr@gmail.com; jcbcorpuz@gmail.com; chontichak.fsn@afrims.org; prinyadar.ca@afrims.org; kittinunh.fsn@afrims.org; yongyuthp.fsn@afrims.org; louis.macareo.mil@afrims.org; stefaniernandez.mil@afrims.org; inkyu.yoon.mil@afrims.org FU U.S. Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance and Response Systems (AFHSC-GEIS) FX This study was funded by the U.S. Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance and Response Systems (AFHSC-GEIS). NR 47 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2015 VL 93 IS 6 BP 1318 EP 1324 DI 10.4269/ajtmh.15-0332 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA CY6TD UT WOS:000366540800032 PM 26416109 ER PT J AU Yang, Y Garver, LS Bingham, KM Hang, J Jochirn, RC Davidson, SA Richardson, JH Jarman, RG AF Yang, Yu Garver, Lindsey S. Bingham, Karen M. Hang, Jun Jochirn, Ryan C. Davidson, Silas A. Richardson, Jason H. Jarman, Richard G. TI Feasibility of Using the Mosquito Blood Meal for Rapid and Efficient Human and Animal Virus Surveillance and Discovery SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID SPECIMEN COLLECTION; FTA CARDS; IDENTIFICATION; EXTRACTION; PATHOGENS; DIAGNOSIS; STORAGE; RNA; DNA AB Mosquito blood meals taken from humans and animals potentially represent a useful source of blood for the detection of blood-borne pathogens. In this feasibility study, Anopheles stephensi mosquitoes were fed with blood meals spiked with dengue virus type 2 (DENV-2) and harvested at serial time points. These mosquitoes are not competent vectors, and the virus is not expected to replicate. Ingested blood was spotted on Whatman VIA cards and stored at room temperature. Mosquito abdomens were removed and stored at 80 degrees C. Control blood meal aliquots were stored in vials or applied onto PTA cards. After 4 weeks of storage, the samples were extracted using beadbeating and QIAamp Viral RNA kit (Qiagen Sciences, Germantown, MD). Recovered viral RNA was analyzed by DENV-2 TaqMan RT-PCR assay and next-generation sequencing (NGS). Overall viral RNA recovery efficiency was 15% from the directly applied dried blood spots and approximately 20% or higher for dried blood spots made by blotting mosquito midgut on PTA cards. Viral RNA in mosquito-ingested blood decreases over time, but remains detectable 24 hours after blood feeding. The viral sequences in FTA-stored specimens can be maintained at room temperature. The strategy has the potential utility in expedited zoonotic virus discovery and blood-borne pathogen surveillance C1 [Yang, Yu; Hang, Jun; Jarman, Richard G.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD 20910 USA. [Garver, Lindsey S.; Davidson, Silas A.] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD 20910 USA. [Bingham, Karen M.] Walter Reed Army Inst Res, Malaria Res Program, Silver Spring, MD 20910 USA. [Jochirn, Ryan C.] Vet Diagnost Technol Inc, Wheat Ridge, CO USA. [Richardson, Jason H.] Armed Forces Pest Management Board, Silver Spring, MD USA. RP Hang, J (reprint author), Walter Reed Army Inst Res, Viral Dis Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM yu.yang2.ctr@mail.mil; lindsey.s.garverbaldwin.ctr@mail.mil; karen.m.bingham2.ctr@mail.mil; jun.hang.civ@mail.mil; ryan.jochim@gmail.com; silas.davidson.mil@afrims.org; jason.h.richardson.mil@mail.mil; richard.g.jarman.mil@mail.mil FU Global Emerging Infections Surveillance and Response System (GEIS), a Division of the Armed Forces Health Surveillance Center; Military Infectious Diseases Research Programs (MIDRP) FX This work was supported by the Global Emerging Infections Surveillance and Response System (GEIS), a Division of the Armed Forces Health Surveillance Center and the Military Infectious Diseases Research Programs (MIDRP). NR 28 TC 1 Z9 1 U1 2 U2 4 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2015 VL 93 IS 6 BP 1377 EP 1382 DI 10.4269/ajtmh.15-0440 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA CY6TD UT WOS:000366540800042 PM 26416112 ER PT J AU Esposito, ER Whitehead, JMA Wilken, JM AF Esposito, Elizabeth Russell Whitehead, Jennifer M. Aldridge Wilken, Jason M. TI Sound limb loading in individuals with unilateral transfemoral amputation across a range of walking velocities SO CLINICAL BIOMECHANICS LA English DT Article DE Amputee; Knee osteoarthritis; Prosthetic; Military; Traumatic; Speed; Kinetics ID COMPARTMENT KNEE OSTEOARTHRITIS; QUADRICEPS STRENGTH; DISEASE PROGRESSION; ARTICULAR-CARTILAGE; PHYSICAL-ACTIVITY; ADDUCTION TORQUE; GAIT PATTERNS; AMPUTEE GAIT; RISK-FACTOR; IN-VITRO AB Background: Individuals with unilateral transfemoral amputation demonstrate significantly increased rates of osteoarthritis in their sound knee. This increased risk is likely the result of altered knee mechanical loading and gait compensations resulting from limited function in the prosthetic limb. Altered knee loading as calculated using loading rates and peak external knee adduction moments and impulses have been associated with both the development and progression of knee osteoarthritis in other populations. The purpose of this study was to determine if young individuals with transfemoral amputation demonstrate biomechanical indicators of increased knee osteoarthritis risk. Methods: Fourteen young male Service Members with unilateral transfemoral amputation and 14 able-bodied service members underwent biomechanical gait analysis at three standardized walking velocities. A two-way ANOVA (group x speed) with unpaired comparisons with Bonferroni-Holm post-hoc corrections assessed statistical significance and effect sizes (d) were calculated. Findings: Normalized peak external knee adduction moments and impulses were 25.7% (P < 0.014, d > 0.994) and 27.1% (P < 0.012, d > 1.019) lower, respectively, in individuals with trans-femoral amputation than controls when averaged across speeds, and effect sizes were large. External knee flexor moments were not, however, different between groups and effect sizes were generally small (P > 0.380, d <0338). Maximal loading rates were significantly greater in individuals with amputation and effect sizes were large (P <0.001, d > 1.644). Interpretation: Individuals with transfemoral amputation did not demonstrate biomechanical risk factors for high medial compartment knee joint loads, but the increased loading rates could place the sound knee at greater risk for cartilage or other tissue damage, even if not localized to the medial compartment Published by Elsevier Ltd. C1 Brooke Army Med Ctr, JBSA, Dept Orthopaed & Rehabil, Ctr Intrepid, Ft Sam Houston, TX 78234 USA. RP Esposito, ER (reprint author), Ctr Intrepid, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Erussell.kin@gmail.com FU Telemedicine and Advanced Technology Research Center; Center for Rehabilitation Sciences Research, Uniformed Services University of the Health Sciences, Bethesda, MD FX This study was supported by the Telemedicine and Advanced Technology Research Center and the Center for Rehabilitation Sciences Research, Uniformed Services University of the Health Sciences, Bethesda, MD. NR 63 TC 0 Z9 0 U1 4 U2 12 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0268-0033 EI 1879-1271 J9 CLIN BIOMECH JI Clin. Biomech. PD DEC PY 2015 VL 30 IS 10 BP 1049 EP 1055 DI 10.1016/j.clinbiomech.2015.09.008 PG 7 WC Engineering, Biomedical; Orthopedics; Sport Sciences SC Engineering; Orthopedics; Sport Sciences GA CZ0JF UT WOS:000366790400005 ER PT J AU Esposito, ER Choi, HS Owens, JG Blanck, RV Wilken, JM AF Esposito, Elizabeth Russell Choi, Harmony S. Owens, Johnny G. Blanck, Ryan V. Wilken, Jason M. TI Biomechanical response to ankle-foot orthosis stiffness during running SO CLINICAL BIOMECHANICS LA English DT Article DE Limb salvage; IDEO; Military; Mechanical work; Joint stiffness; Kinetics; Kinematics ID LOWER-EXTREMITY TRAUMA; OPERATION ENDURING FREEDOM; LIMB-LENGTH DISCREPANCY; PLANTARFLEXOR WEAKNESS; PHYSICAL-THERAPY; GAIT ASYMMETRY; IRAQI FREEDOM; AMPUTATION; WALKING; PERFORMANCE AB Background: The Intrepid Dynamic Exoskeletal Orthosis (IDEO) is an ankle-foot orthosis developed to address the high rates of delayed amputation in the military. Its use has enabled many wounded Service Members to run again. During running, stiffness is thought to influence an orthosis' energy storage and return mechanical properties. This study examined the effect of orthosis stiffness on running biomechanics in patients with lower limb impairments who had undergone unilateral limb salvage. Methods: Ten patients with lower limb impairments underwent gait analysis at a self-selected running velocity. 1. Nominal (clinically-prescribed), 2. Stiff (20% stiffer than nominal), and 3. Compliant (20% less stiff than nominal) ankle-foot orthosis stiffnesses were tested. Findings: Ankle joint stiffness was greatest in the stiffest strut and lowest in the compliant strut, however ankle mechanical work remained unchanged. Speed, stride length, cycle time, joint angles, moments, powers, and ground reaction forces were not significantly different among stiffness conditions. Ankle joint kinematics and ankle, knee and hip kinetics were different between limbs. Ankle power, in particular, was lower in the injured limb. Interpretation: Ankle-foot orthosis stiffness affected ankle joint stiffness but did not influence other biomechanical parameters of running in individuals with unilateral limb salvage. Foot strike asymmetries may have influenced the kinetics of running. Therefore, a range of stiffness may be clinically appropriate when prescribing ankle-foot orthoses for active individuals with limb salvage. Published by Elsevier Ltd. C1 [Esposito, Elizabeth Russell; Choi, Harmony S.; Owens, Johnny G.; Blanck, Ryan V.; Wilken, Jason M.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ctr Intrepid, Ft Sam Houston, TX 78234 USA. RP Esposito, ER (reprint author), Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ctr Intrepid, Ft Sam Houston, TX 78234 USA. EM erussell.kin@gmail.com FU Center for Rehabilitation Sciences Research (CRSR), Department of Physical Medicine and Rehabilitation, Uniformed Services University of Health Sciences, Bethesda, MD FX The authors gratefully acknowledge Derek Haight, Jennifer Aldridge Whitehead, Kelly Rodriguez and Dr. Deanna Gates at the Center for the Intrepid for their assistance with data collection and processing, and Nicole Harper and Dr. Richard Neptune at the University of Texas for design and fabrication of the struts. Support for this study was provided by the Center for Rehabilitation Sciences Research (CRSR), Department of Physical Medicine and Rehabilitation, Uniformed Services University of Health Sciences, Bethesda, MD. NR 55 TC 1 Z9 1 U1 3 U2 15 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0268-0033 EI 1879-1271 J9 CLIN BIOMECH JI Clin. Biomech. PD DEC PY 2015 VL 30 IS 10 BP 1125 EP 1132 DI 10.1016/j.clinbiomech.2015.08.014 PG 8 WC Engineering, Biomedical; Orthopedics; Sport Sciences SC Engineering; Orthopedics; Sport Sciences GA CZ0JF UT WOS:000366790400018 ER PT J AU Keevin, TM Nico, LG Taphorn, DC AF Keevin, Thomas M. Nico, Leo G. Taphorn, Donald C. TI Jamie Edward Thomerson (1935-2015) OBITUARY SO COPEIA LA English DT Biographical-Item C1 [Keevin, Thomas M.] US Army Corps Engineers, St Louis, MO 63103 USA. [Nico, Leo G.] US Geol Survey, Gainesville, FL 32653 USA. RP Keevin, TM (reprint author), US Army Corps Engineers, 1222 Spruce St, St Louis, MO 63103 USA. EM Keevintm@yahoo.com; lnico@usgs.gov; Taphorn@gmail.com NR 2 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC ICHTHYOLOGISTS & HERPETOLOGISTS PI MIAMI PA MAUREEN DONNELLY, SECRETARY FLORIDA INT UNIV BIOLOGICAL SCIENCES, 11200 SW 8TH STREET, MIAMI, FL 33199 USA SN 0045-8511 EI 1938-5110 J9 COPEIA JI Copeia PD DEC PY 2015 VL 103 IS 4 BP 1096 EP 1101 DI 10.1643/OT-15-331 PG 6 WC Zoology SC Zoology GA CY8SX UT WOS:000366679700026 ER PT J AU Westbrook, CJ Karl, JA Wiseman, RW Mate, S Koroleva, G Garcia, K Sanchez-Lockhart, M O'Connor, DH Palacios, G AF Westbrook, Catherine J. Karl, Julie A. Wiseman, Roger W. Mate, Suzanne Koroleva, Galina Garcia, Karla Sanchez-Lockhart, Mariano O'Connor, David H. Palacios, Gustavo TI No assembly required: Full-length MHC class I allele discovery by PacBio circular consensus sequencing SO HUMAN IMMUNOLOGY LA English DT Article DE MHC class I; Cynomolgus macaques; Single-molecule real-time circular consensus sequencing (SMRT-CCS); PacBio ID MAJOR HISTOCOMPATIBILITY COMPLEX; IMMUNODEFICIENCY VIRUS-REPLICATION; MAURITIAN CYNOMOLGUS MACAQUES; RHESUS MACAQUES; MOLECULES; HAPLOTYPES; PLATFORMS AB Single-molecule real-time (SMRT) sequencing technology with the Pacific Biosciences (PacBio) RS II platform offers the potential to obtain full-length coding regions (similar to 1100-bp) from MHC class I cDNAs. Despite the relatively high error rate associated with SMRT technology, high quality sequences can be obtained by circular consensus sequencing (CCS) due to the random nature of the error profile. In the present study we first validated the ability of SMRT-CCS to accurately identify class I transcripts in Mauritian-origin cynomolgus macaques (Macaca fascicularis) that have been characterized previously by cloning and Sanger-based sequencing as well as pyrosequencing approaches. We then applied this SMRT-CCS method to characterize 60 novel full-length class I transcript sequences expressed by a cohort of cynomolgus macaques from China. The SMRT-CCS method described here provides a straightforward protocol for characterization of unfragmented single-molecule cDNA transcripts that will potentially revolutionize MHC class I allele discovery in nonhuman primates and other species. Published by Elsevier Inc. on behalf of American Society for Histocompatibility and Immunogenetics. C1 [Westbrook, Catherine J.; Mate, Suzanne; Koroleva, Galina; Garcia, Karla; Sanchez-Lockhart, Mariano; Palacios, Gustavo] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Karl, Julie A.; Wiseman, Roger W.; O'Connor, David H.] Univ Wisconsin, Wisconsin Natl Primate Res Ctr, Madison, WI 53711 USA. [O'Connor, David H.] Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI 53705 USA. RP Sanchez-Lockhart, M (reprint author), 1425 Porter St, Ft Detrick, MD 21702 USA. EM Mariano.sanchez-lockhart.ctr@mail.mil RI Palacios, Gustavo/I-7773-2015; OI Palacios, Gustavo/0000-0001-5062-1938; o'connor, david/0000-0003-2139-470X FU Defense Threat Reduction Agency under USAMRIID project [3174512]; National Institute of Allergy and Infectious Diseases [HHSN272201100013C]; Research Facilities Improvement Program [RR15459-01, RR020141-01] FX This work was supported by Defense Threat Reduction Agency under USAMRIID project number 3174512. This study was also supported by the National Institute of Allergy and Infectious Diseases (HHSN272201100013C) and was conducted in part at a facility constructed with support from the Research Facilities Improvement Program (RR15459-01, RR020141-01). NR 29 TC 8 Z9 9 U1 3 U2 10 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0198-8859 EI 1879-1166 J9 HUM IMMUNOL JI Hum. Immunol. PD DEC PY 2015 VL 76 IS 12 SI SI BP 891 EP 896 DI 10.1016/j.humimm.2015.03.022 PG 6 WC Immunology SC Immunology GA CY5HE UT WOS:000366437900003 PM 26028281 ER PT J AU Pradhan, NR McCreary, A Rhodes, D Lu, ZG Feng, SM Manousakis, E Smirnov, D Namburu, R Dubey, M Walker, ARH Terrones, H Terrones, M Dobrosavljevic, V Balicas, L AF Pradhan, Nihar R. McCreary, Amber Rhodes, Daniel Lu, Zhengguang Feng, Simin Manousakis, Efstratios Smirnov, Dmitry Namburu, Raju Dubey, Madan Walker, Angela R. Hight Terrones, Humberto Terrones, Mauricio Dobrosavljevic, Vladimir Balicas, Luis TI Metal to Insulator Quantum-Phase Transition in Few-Layered ReS2 SO NANO LETTERS LA English DT Article DE Transition metal dichalcogenides; rhenium disulfide; Raman scattering; field-effect transistor; field-effect mobilities; metal-insulator transition ID FIELD-EFFECT TRANSISTORS; 2 DIMENSIONS; MOS2 TRANSISTORS; MOLYBDENUM-DISULFIDE; SINGLE-LAYER; WS2; LOCALIZATION; MONOLAYER; HALL; MOBILITIES AB In ReS2, a layer-independent direct band gap of 1.5 eV implies a potential for its use in optoelectronic applications. ReS2 crystallizes in the 1T'-structure, which leads to anisotropic physical properties and whose concomitant electronic structure might host a nontrivial topology. Here, we report an overall evaluation of the anisotropic Raman response and the transport properties of few-layered ReS2 field-effect transistors. We find that ReS2 exfoliated on SiO2 behaves as an n-type semiconductor with an intrinsic carrier mobility surpassing mu(i) similar to 30 cm(2)/(V s) at T = 300 K, which increases up to similar to 350 cm(2)/(V s) at 2 K. Semiconducting behavior is observed at low electron densities n, but at high values of n the resistivity decreases by a factor of >7 upon cooling to 2 K and displays a metallic T-2-dependence. This suggests that the band structure of 1T'-ReS2 is quite susceptible to an electric field applied perpendicularly to the layers. The electric-field induced metallic state observed in transition metal dichalcogenides was recently claimed to result from a percolation type of transition. Instead, through a scaling analysis of the conductivity as a function of T and n, we find that the metallic state of ReS2 results from a second-order metal-to-insulator transition driven by electronic correlations. This gate-induced metallic state offers an alternative to phase engineering for producing ohmic contacts and metallic interconnects in devices based on transition metal dichalcogenides. C1 [Pradhan, Nihar R.; Rhodes, Daniel; Lu, Zhengguang; Manousakis, Efstratios; Smirnov, Dmitry; Dobrosavljevic, Vladimir; Balicas, Luis] Florida State Univ, Natl High Magnet Field Lab, Tallahassee, FL 32310 USA. [McCreary, Amber; Feng, Simin; Terrones, Mauricio] Penn State Univ, Dept Phys, State Coll, PA 16802 USA. [McCreary, Amber; Feng, Simin; Terrones, Mauricio] Penn State Univ, Ctr Dimens & Layered Mat 2, State Coll, PA 16802 USA. [McCreary, Amber; Namburu, Raju] US Army, Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA. [McCreary, Amber; Dubey, Madan] US Army, Res Lab, Sensor & Electron Devices Directorate, Adelphi, MD 20783 USA. [Rhodes, Daniel; Lu, Zhengguang; Manousakis, Efstratios; Dobrosavljevic, Vladimir] Florida State Univ, Dept Phys, Tallahassee, FL 32306 USA. [Walker, Angela R. Hight] NIST, Div Engn Phys, Phys Lab, Gaithersburg, MD 20899 USA. [Terrones, Humberto] Rensselaer Polytech Inst, Dept Phys Appl Phys & Astron, Troy, NY 12180 USA. [Terrones, Mauricio] Penn State Univ, Dept Chem, State Coll, PA 16802 USA. [Terrones, Mauricio] Penn State Univ, Dept Mat Sci & Engn, State Coll, PA 16802 USA. [Terrones, Mauricio] Shinshu Univ, Carbon Inst Sci & Technol, Nagano 3808553, Japan. RP Balicas, L (reprint author), Florida State Univ, Natl High Magnet Field Lab, 1800 East Paul Dirac Dr, Tallahassee, FL 32310 USA. EM balicas@magnet.fsu.edu FU U.S. Army Research Office MURI [W911NF-11-1-0362]; NHMFL UCGP [5087]; DOE BES Division [DE-FG02-07ER46451]; NSF [NSF-DMR-0084173, DMR-1410132]; State of Florida; National Science Foundation [EFRI-1433311]; US Army Research Laboratory (ARL) Director's Strategic Initiative (DSI) FX This work was supported by the U.S. Army Research Office MURI Grant No. W911NF-11-1-0362. J.L. acknowledges the support by NHMFL UCGP No. 5087. Z.L. and D.S. acknowledge the support by DOE BES Division under Grant No. DE-FG02-07ER46451. The NHMFL is supported by NSF through NSF-DMR-0084173 and the State of Florida. H.T. acknowledges the support from the National Science Foundation (EFRI-1433311). A.M., R.R.N., and M.D. acknowledge the support from the US Army Research Laboratory (ARL) Director's Strategic Initiative (DSI) program on interfaces in stacked 2D atomic layered materials. V.D. is supported by the NSF through Grant No. DMR-1410132. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 42 TC 11 Z9 11 U1 24 U2 130 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1530-6984 EI 1530-6992 J9 NANO LETT JI Nano Lett. PD DEC PY 2015 VL 15 IS 12 BP 8377 EP 8384 DI 10.1021/acs.nanolett.5b04100 PG 8 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA CY3WC UT WOS:000366339600091 PM 26599563 ER PT J AU Hill, KK Xie, G Foley, BT Smith, TJ AF Hill, K. K. Xie, G. Foley, B. T. Smith, T. J. TI Genetic diversity within the botulinum neurotoxin-producing bacteria and their neurotoxins SO TOXICON LA English DT Article; Proceedings Paper CT TOXINS 2015 Basic Science and Clinical Aspects of Botulinum and Other Neurotoxins CY JAN 14-17, 2015 CL Lisbon, PORTUGAL SP Intl Neurotoxin Assoc (INA) DE Genetic diversity; Botulinum neurotoxin; Clostridium botulinum ID II CLOSTRIDIUM-BOTULINUM; C-NEUROTOXIN; E STRAINS; CLUSTER; ORGANIZATION; SEQUENCES; COMPLEX AB The recent availability of multiple Clostridium botulinum genomic sequences has initiated a new genomics era that strengthens our understanding of the bacterial species that produce botulinum neurotoxins (BoNTs). Analysis of the genomes has reinforced the historical Group I-VI designations and provided evidence that the bont genes can be located within the chromosome, phage or plasmids. The sequences provide the opportunity to examine closely the variation among the toxin genes, the composition and organization of the toxin complex, the regions flanking the toxin complex and the location of the toxin within different bacterial strains. These comparisons provide evidence of horizontal gene transfer and site-specific insertion and recombination events that have contributed to the variation observed among the neurotoxins. Here, examples that have contributed to the variation observed in serotypes A-H strains are presented to illustrate the mechanisms that have contributed to their variation. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Hill, K. K.; Xie, G.] Los Alamos Natl Lab, Biosci Div, Los Alamos, NM 87545 USA. [Foley, B. T.] Los Alamos Natl Lab, Div Theoret, Los Alamos, NM 87545 USA. [Smith, T. J.] US Army, Med Res Inst Infect Dis, Mol & Translat Sci Div, Ft Detrick, MD 21702 USA. RP Hill, KK (reprint author), Los Alamos Natl Lab, Biosci Div, MS M88, Los Alamos, NM 87545 USA. EM khill@lanl.gov OI Foley, Brian/0000-0002-1086-0296; xie, gary/0000-0002-9176-924X FU NIH/NIAID [U01 AI056493] FX This research was partially funded by a grant from NIH/NIAID U01 AI056493. The opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. NR 31 TC 8 Z9 8 U1 2 U2 11 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD DEC 1 PY 2015 VL 107 SI SI BP 2 EP 8 DI 10.1016/j.toxicon.2015.09.011 PN A PG 7 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA CY6SP UT WOS:000366539400002 PM 26368006 ER PT J AU Reinard, KA Pabaney, AH Basheer, A Phillips, SB Kole, MK Malik, GM AF Reinard, Kevin A. Pabaney, Aqueel H. Basheer, Azam Phillips, Scott B. Kole, Max K. Malik, Ghaus M. TI Surgical Management of Giant Intracranial Arteriovenous Malformations: A Single Center Experience over 32 years SO WORLD NEUROSURGERY LA English DT Article DE Embolization; Giant intracranial arteriovenous malformations (gAVMs); Hemorrhage; Management; Microsurgery ID LINEAR-ACCELERATOR RADIOSURGERY; MARTIN GRADE-IV; TERM-FOLLOW-UP; NATURAL-HISTORY; STEREOTACTIC RADIOSURGERY; MULTIMODALITY TREATMENT; MICROSURGICAL TREATMENT; TREATMENT PARADIGM; STROKE TRIALS; BRAIN AB OBJECTIVE: Treatment of giant intracranial arteriovenous malformations (gAVMs) is a formidable challenge for neurosurgeons and carries significant morbidity and mortality rates for patients compared with smaller AVMs. In this study, we reviewed the treatments, angiographic results, and clinical outcomes in 64 patients with gAVMs who were treated at Henry Ford Hospital between 1980 and 2012. METHODS: The arteriovenous malformation (AVM) database at our institution was queried for patients with gAVMs (>= 6 cm) and data regarding patient demographics, presentation, AVM angioarchitecture, and treatments were collected. Functional outcomes as well as complications were analyzed. RESULTS: Of the 64 patients, 33 (51.6%) were female and 31 (48.4%) were male, with an average age of 45.7 years (SD +/- 15.5). The most common symptoms on presentation were headaches (50%), seizures (50%), and hemorrhage (41%). The mean AVM size was 6.65 cm (range, 6-9 cm). Only 6 AVMs (9.4%) were located in the posterior fossa. The most common Spetzler-Martin grade was V, seen in 64% of patients. Of the 64 patients, 42 (66%) underwent surgical excision, 10 (15.5%) declined any treatment, 8 (12.5%) were deemed inoperable and followed conservatively, 2 (3%) had stand-alone embolization, 1 (1.5%) had embolization before stereotactic radiosurgery, and 1 (1.5%) received stereotactic radiosurgery only. Complete obliteration was achieved in 90% of the surgical patients. Mortality rate was 19% in the surgical cohort compared with 22% in the observation cohort (P = 0.770). CONCLUSIONS: Treatment of gAVMs carries significant morbidity and mortality; however, good outcomes are attainable with a multimodal treatment approach in carefully selected patients. C1 [Reinard, Kevin A.; Pabaney, Aqueel H.; Basheer, Azam; Kole, Max K.; Malik, Ghaus M.] Henry Ford Hosp, Dept Neurosurg, Detroit, MI 48202 USA. [Phillips, Scott B.] Brooke Army Med Ctr, Div Neurol Surg, San Antonio, TX USA. RP Pabaney, AH (reprint author), Henry Ford Hosp, Dept Neurosurg, Detroit, MI 48202 USA. EM apabane1@hfhs.org NR 68 TC 1 Z9 1 U1 1 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1878-8750 EI 1878-8769 J9 WORLD NEUROSURG JI World Neurosurg. PD DEC PY 2015 VL 84 IS 6 BP 1765 EP 1778 DI 10.1016/j.wneu.2015.07.051 PG 14 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA CY3CQ UT WOS:000366286300052 PM 26232210 ER PT J AU Stewart, IJ Sosnov, JA Howard, JT Orman, JA Fang, R Morrow, BD Zonies, DH Bollinger, M Tuman, C Freedman, BA Chung, KK AF Stewart, Ian J. Sosnov, Jonathan A. Howard, Jeffrey T. Orman, Jean A. Fang, Raymond Morrow, Benjamin D. Zonies, David H. Bollinger, Mary Tuman, Caroline Freedman, Brett A. Chung, Kevin K. TI Retrospective Analysis of Long-Term Outcomes After Combat Injury A Hidden Cost of War SO CIRCULATION LA English DT Article DE coronary disease; diabetes mellitus; hypertension; kidney; mortality ID POSTTRAUMATIC-STRESS-DISORDER; CHRONIC KIDNEY-DISEASE; VA HEALTH-CARE; MILITARY SERVICE; COMPETING RISK; PREVALENCE; SEVERITY; SYSTEM; AKI; HYPERTENSION AB Background During the conflicts in Iraq and Afghanistan, 52087 service members have been wounded in combat. The long-term sequelae of these injuries have not been carefully examined. We sought to determine the relation between markers of injury severity and the subsequent development of hypertension, coronary artery disease, diabetes mellitus, and chronic kidney disease. Methods and Results Retrospective cohort study of critically injured US military personnel wounded in Iraq or Afghanistan from February 1, 2002 to February 1, 2011. Patients were then followed until January 18, 2013. Chronic disease outcomes were assessed by International Classification of Diseases, 9th edition codes and causes of death were confirmed by autopsy. From 6011 admissions, records were excluded because of missing data or if they were for an individual's second admission. Patients with a disease diagnosis of interest before the injury date were also excluded, yielding a cohort of 3846 subjects for analysis. After adjustment for other factors, each 5-point increment in the injury severity score was associated with a 6%, 13%, 13%, and 15% increase in incidence rates of hypertension, coronary artery disease, diabetes mellitus, and chronic kidney disease, respectively. Acute kidney injury was associated with a 66% increase in rates of hypertension and nearly 5-fold increase in rates of chronic kidney disease. Conclusions In Iraq and Afghanistan veterans, the severity of combat injury was associated with the subsequent development of hypertension, coronary artery disease, diabetes mellitus, and chronic kidney disease. C1 [Stewart, Ian J.] David Grant Med Ctr, Travis Afb, CA 94535 USA. [Stewart, Ian J.; Sosnov, Jonathan A.; Morrow, Benjamin D.; Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Sosnov, Jonathan A.; Morrow, Benjamin D.] San Antonio Mil Med Ctr, San Antonio, TX USA. [Howard, Jeffrey T.; Orman, Jean A.; Chung, Kevin K.] US Army Inst Surg Res, San Antonio, TX USA. [Fang, Raymond] US Air Force Ctr Sustainment Trauma & Readiness S, Baltimore, MD USA. [Zonies, David H.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. [Bollinger, Mary] South Texas Vet Hlth Care Syst, San Antonio, TX USA. [Tuman, Caroline; Freedman, Brett A.] Landstuhl Reg Med Ctr, Landstuhl, Germany. RP Stewart, IJ (reprint author), David Grant Med Ctr, Clin Invest Facil, 101 Bodin Circle, Travis Afb, CA 94535 USA. EM ian.stewart@us.af.mil FU Oak Ridge Institute of Science and Education FX This study was funded in part by a postdoctoral fellowship provided by the Oak Ridge Institute of Science and Education. NR 39 TC 3 Z9 3 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0009-7322 EI 1524-4539 J9 CIRCULATION JI Circulation PD DEC 1 PY 2015 VL 132 IS 22 BP 2126 EP 2133 DI 10.1161/CIRCULATIONAHA.115.016950 PG 8 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA CY1SE UT WOS:000366187100005 PM 26621637 ER PT J AU Anisowicz, SK Abadie, JM AF Anisowicz, Sarah K. Abadie, Jude M. TI Six-Month-Old Boy with "Milky" Serum SO CLINICAL CHEMISTRY LA English DT Editorial Material ID HYPERTRIGLYCERIDEMIA C1 [Anisowicz, Sarah K.] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. [Abadie, Jude M.] Tripler Army Med Ctr, Dept Pathol, Honolulu, HI 96859 USA. RP Anisowicz, SK (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd,MCHK PE, Honolulu, HI 96859 USA. EM sarah.k.anisowicz.mil@mail.mil NR 9 TC 1 Z9 1 U1 0 U2 1 PU AMER ASSOC CLINICAL CHEMISTRY PI WASHINGTON PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA SN 0009-9147 EI 1530-8561 J9 CLIN CHEM JI Clin. Chem. PD DEC PY 2015 VL 61 IS 12 BP 1441 EP 1443 DI 10.1373/clinchem.2014.235143 PG 3 WC Medical Laboratory Technology SC Medical Laboratory Technology GA CY0BT UT WOS:000366071900004 PM 26614227 ER PT J AU Tahmoush, D Ling, H Stankovic, L Thayaparan, T Narayanan, R AF Tahmoush, David Ling, Hao Stankovic, Ljubisa Thayaparan, Thayananthan Narayanan, Ram TI Current Research in Micro-Doppler: Editorial for the Special Issue on Micro-Doppler SO IET RADAR SONAR AND NAVIGATION LA English DT Editorial Material DE digital signatures; electric sensing devices; Doppler effect; feature extraction; micro-Doppler technique; micro-Doppler signature identification; micromotion; active emitter; micro-Doppler capable sensor; salient feature extraction ID CLASSIFICATION; DECOMPOSITION; SIGNATURES C1 [Tahmoush, David] US Army Res Lab, Adelphi, MD 20783 USA. [Ling, Hao] Univ Texas Austin, Elect & Comp Engn, Austin, TX 78712 USA. [Stankovic, Ljubisa] Univ Montenegro, Podgorica, Montenegro. [Thayaparan, Thayananthan] Univ Western Ontario, London, ON N6A 3K7, Canada. [Thayaparan, Thayananthan] Def Res & Dev Canada, Ottawa, ON, Canada. [Thayaparan, Thayananthan] McMaster Univ, Hamilton, ON L8S 4L8, Canada. [Narayanan, Ram] Penn State Univ, Elect Engn, University Pk, PA 16802 USA. RP Tahmoush, D (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. NR 35 TC 0 Z9 0 U1 2 U2 6 PU INST ENGINEERING TECHNOLOGY-IET PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND SN 1751-8784 EI 1751-8792 J9 IET RADAR SONAR NAV JI IET Radar Sonar Navig. PD DEC PY 2015 VL 9 IS 9 SI SI BP 1137 EP 1139 DI 10.1049/iet-rsn.2015.0547 PG 3 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA CX7BK UT WOS:000365855500001 ER PT J AU Tahmoush, D AF Tahmoush, Dave TI Review of micro-Doppler signatures SO IET RADAR SONAR AND NAVIGATION LA English DT Review DE Doppler radar; radar signal processing; helicopters; autonomous aerial vehicles; micro-Doppler signatures; micro-Doppler signals; kinematic properties; salient feature extraction; micro-Doppler-capable active sensors; fixed-wing aircraft; multiple spinning rotor blades; helicopter; unmanned aerial vehicle; confuser detections ID EMPIRICAL-MODE DECOMPOSITION; BISTATIC SEA CLUTTER; RADAR SIGNATURES; ROTATING PARTS; TIME-FREQUENCY; PERSONNEL TARGETS; RIGID TARGETS; LOW-COST; CLASSIFICATION; MICROMOTION AB Micro-Doppler signals refer to Doppler scattering returns produced by the motions of the target other than gross translation. The small micro-motions of a subject, and even just parts of a subject, can be observed through the micro-Doppler signature it creates in response to an active emitter such as a radar, laser, and even acoustic emitters. These micro-Doppler signatures are produced by the kinematic properties of the subject's motion and can be used to extract the salient features of the subject's motion, and often, identify the subject. The rapidly declining cost of micro-Doppler-capable active sensors like radar with their dramatically improving capabilities, provide significant motivation in developing micro-Doppler techniques that can improve the exploitation of these sensors. Micro-Doppler techniques aim at extracting the micro-motion of the subject that may be unique to a particular subject class or activity in order to distinguish probable false alarms from real detections, as well as to increase the value of the information extracted from the sensor. The source of micro-motion depends on the subject and can be a rotating propeller on a fixed-wing aircraft, the multiple spinning rotor blades of a helicopter, or an unmanned aerial vehicle (UAV); the vibrations of an engine shaking a vehicle; an antenna rotating on a ship; the flapping wings of birds; the swinging arms and legs of a walking person; and many other sources. Confuser detections, such as birds for UAVs or animals for humans, can be interpreted as false alarms for a sensor system, so using the available micro-Doppler returns for classification can significantly reduce the sensor false alarm rate, thereby improving the utility of the sensor system. This study reviews the current research in micro-Doppler based on subject type, sensor capabilities, as well as environmental effects, and then proposes future research areas for micro-Doppler. C1 [Tahmoush, Dave] US Army Res Lab, Adelphi, MD 20783 USA. RP Tahmoush, D (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM david.tahmoush.civ@mail.mil NR 143 TC 9 Z9 10 U1 5 U2 24 PU INST ENGINEERING TECHNOLOGY-IET PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND SN 1751-8784 EI 1751-8792 J9 IET RADAR SONAR NAV JI IET Radar Sonar Navig. PD DEC PY 2015 VL 9 IS 9 SI SI BP 1140 EP 1146 DI 10.1049/iet-rsn.2015.0118 PG 7 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA CX7BK UT WOS:000365855500002 ER PT J AU Peachman, KK Karasavvas, N Chenine, AL McLinden, R Rerks-Ngarm, S Jaranit, K Nitayaphan, S Pitisuttithum, P Tovanabutra, S Zolla-Pazner, S Michael, NL Kim, JH Alving, CR Rao, M AF Peachman, Kristina K. Karasavvas, Nicos Chenine, Agnes-Laurence McLinden, Robert Rerks-Ngarm, Supachai Jaranit, Kaewkungwal Nitayaphan, Sorachai Pitisuttithum, Punnee Tovanabutra, Sodsai Zolla-Pazner, Susan Michael, Nelson L. Kim, Jerome H. Alving, Carl R. Rao, Mangala TI Identification of New Regions in HIV-1 gp120 Variable 2 and 3 Loops that Bind to alpha 4 beta 7 Integrin Receptor SO PLOS ONE LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; CD4(+) T-CELLS; ENVELOPE GLYCOPROTEIN; MONOCLONAL-ANTIBODY; VACCINE EFFICACY; MUCOSAL TRANSMISSION; INFECTION; ALPHA(4)BETA(7); V2; NEUTRALIZATION AB Background The gut mucosal homing integrin receptor alpha 4 beta 7 present on activated CD4(+) T cells interacts with the HIV-1 gp120 second variable loop (V2). Case control analysis of the RV144 phase III vaccine trial demonstrated that plasma IgG binding antibodies specific to scaffolded proteins expressing the first and second variable regions (V1V2) of HIV envelope protein gp120 containing the alpha 4 beta 7 binding motif correlated inversely with risk of infection. Subsequently antibodies to the V3 region were also shown to correlate with protection. The integrin receptor alpha 4 beta 7 was shown to interact with the LDI/V motif on V2 loop but recent studies suggest that additional regions of V2 loop could interact with the alpha 4 beta 7. Thus, there may be several regions on the V2 and possibly V3 loops that may be involved in this binding. Using a cell line, that constitutively expressed alpha 4 beta 7 receptors but lacked CD4, we examined the contribution of V2 and V3 loops and the ability of V2 peptide-, V2 integrin-, V3-specific monoclonal antibodies (mAbs), and purified IgG from RV144 vaccinees to block the V2/V3-alpha 4 beta 7 interaction. Results We demonstrate that alpha 4 beta 7 on RPMI8866 cells bound specifically to its natural ligand mucosal addressin cell adhesion molecule-1 (MAdCAM-1) as well as to cyclic-V2 and cyclic-V3 peptides. This binding was inhibited by anti-alpha 4 beta 7-specific monoclonal antibody (mAb) ACT-1, mAbs specific to either V2 or V3 loops, and by purified primary virions or infectious molecular clones expressing envelopes from acute or chronic subtypes A, C, and CRF01_AE viruses. Plasma from HIV-1 infected Thai individuals as well as purified IgG from uninfected RV144 vaccinees inhibited (0-50%) the binding of V2 and V3 peptides to alpha 4 beta 7. Conclusion Our results indicate that in addition to the tripeptide LDI/V motif, other regions of the V2 and V3 loops of gp120 were involved in binding to alpha 4 beta 7 receptors and this interaction was blocked by anti-V2 peptide, anti-V2 integrin, and anti-V3 antibodies. The ability of purified IgG from some of the uninfected RV144 vaccinees to inhibit alpha 4 beta 7 raises the hypothesis that anti-V2 and anti-V3 antibodies may play a role in blocking the gp120-alpha 4 beta 7 interaction after vaccination and thus prevent HIV-1 acquisition. C1 [Peachman, Kristina K.; Chenine, Agnes-Laurence; McLinden, Robert; Tovanabutra, Sodsai; Michael, Nelson L.; Kim, Jerome H.; Alving, Carl R.; Rao, Mangala] US Mil HIV Res Program, Walter Reed Army Inst Res, Silver Spring, MD USA. [Peachman, Kristina K.; Chenine, Agnes-Laurence; McLinden, Robert; Tovanabutra, Sodsai] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Karasavvas, Nicos] US Army Med Component, Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Bangkok, Thailand. [Jaranit, Kaewkungwal] Mahidol Univ, Data Management Unit, Bangkok 10700, Thailand. [Nitayaphan, Sorachai] Armed Forces Res Inst Med Sci, Royal Thai Army, Bangkok 10400, Thailand. [Pitisuttithum, Punnee] Mahidol Univ, Vaccine Trials Ctr, Bangkok 10700, Thailand. [Zolla-Pazner, Susan] Vet Adm New York Harbor Hlth Care Syst, Sch Med, New York, NY USA. [Zolla-Pazner, Susan] NYU, Sch Med, New York, NY USA. RP Rao, M (reprint author), US Mil HIV Res Program, Walter Reed Army Inst Res, Silver Spring, MD USA. EM mrao@hivresearch.org FU Henry M. Jackson Foundation [W81XWH-11-2-0174]; US Department of Defense [W81XWH-11-2-0174]; National Institutes of Allergy and Infectious Diseases [AI 100151]; Department of Veterans Affairs FX This work was supported by a cooperative agreement (W81XWH-11-2-0174) between the Henry M. Jackson Foundation and the US Department of Defense. SZ-P is supported by a grant from the National Institutes of Allergy and Infectious Diseases (AI 100151) and by funds from the Department of Veterans Affairs. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 69 TC 2 Z9 2 U1 1 U2 10 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 1 PY 2015 VL 10 IS 12 AR e0143895 DI 10.1371/journal.pone.0143895 PG 25 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CX7OL UT WOS:000365891600071 PM 26625359 ER PT J AU Rosenstein, JE Carroll, MH AF Rosenstein, Judith E. Carroll, Marjorie H. TI Male Rape Myths, Female Rape Myths, and Intent to Intervene as a Bystander SO VIOLENCE AND GENDER LA English DT Article ID SEXUAL VIOLENCE; COLLEGE-STUDENTS; GENDER; PREVENTION; ACCEPTANCE; BEHAVIOR; SEXISM; VICTIM; MODEL; HELP AB The bystander approach to sexual assault prevention has become popular on college campuses and within the military. Previous research has identified a negative association between the acceptance of rape myths and the likelihood of individuals intervening in a sexual assault situation. However, to date, all examinations of rape myth acceptance (RMA) and bystander intervention have focused on female rape myths (i.e., myths about rape involving a female victim). The current study explored whether male RMA (i.e., acceptance of myths about rape involving a male victim) influences bystander intervention in similar or differing ways compared with female RMA. In addition, the study explored whether male and female RMA function differently by subtypes of bystander intervention (i.e., known victim vs. stranger victim) and bystander gender. Participants included 970 students (731 men, 239 women) entering the United States Naval Academy. Participants completed the Illinois Rape Myth Acceptance ScaleShort Form, a 30-item male RMA scale, and the Intent to Help Friends and Intent to Help Strangers scales. The findings indicated that higher acceptance of both female and male rape myths was associated with a lowered intent to help someone known to the bystander. In contrast, after controlling for both types of RMA, only male RMA had a negative relationship with intent to help a stranger. These findings highlight the need to incorporate a discussion of male victimization and associated myths into bystander intervention programs. C1 [Rosenstein, Judith E.] US Naval Acad, Dept Leadership Eth & Law, Annapolis, MD 21401 USA. [Carroll, Marjorie H.] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. RP Rosenstein, JE (reprint author), US Naval Acad, Dept Leadership Eth & Law, 112 Cooper Rd,Stop 7B, Annapolis, MD 21401 USA. EM rosenste@usna.edu NR 30 TC 1 Z9 1 U1 6 U2 33 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 2326-7836 EI 2326-7852 J9 VIOLENCE GEND JI Violence Gend. PD DEC 1 PY 2015 VL 2 IS 4 BP 204 EP 208 DI 10.1089/vio.2015.0027 PG 5 WC Criminology & Penology SC Criminology & Penology GA CY3LE UT WOS:000366310200004 ER PT J AU Copeland, AM Van Deusen, NM Schmaljohn, CS AF Copeland, Anna Maria Van Deusen, Nicole M. Schmaljohn, Connie S. TI Rift Valley fever virus NSS gene expression correlates with a defect in nuclear mRNA export SO VIROLOGY LA English DT Article DE mRNA; Rift Valley fever virus; NSS; RNA export; PABP1 ID VESICULAR STOMATITIS-VIRUS; INFECTED-CELLS; BINDING-PROTEIN; MATRIX PROTEIN; SEGMENT; TRANSCRIPTION; INHIBITION; SEQUENCES; P62 AB We investigated the localization of host mRNA during Rift Valley fever virus (RVFV) infection. Fluorescence in situ hybridization revealed that infection with RVFV altered the localization of host mRNA. mRNA accumulated in the nuclei of RVFV-infected but not mock-infected cells. Further, overexpression of the NSs gene, but not the N, G(N) or NSM genes correlated with mRNA nuclear accumulation. Nuclear accumulation of host mRNA was not observed in cells infected with a strain of RVFV lacking the gene encoding NSs, confirming that expression of NSs is likely responsible for this phenomenon. Published by Elsevier Inc. C1 [Copeland, Anna Maria; Van Deusen, Nicole M.; Schmaljohn, Connie S.] US Army Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Schmaljohn, CS (reprint author), US Army Med Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA. EM Connie.s.schmaljohn.civ@mail.mil FU Joint Sciences and Technology Office of the US Defense Threat Reduction Agency FX The authors wish to thank Stuart Nichol (Centers for Disease Control), Julie Costantino (USAMRIID), Sheli Radoshitzlcy (USAMRIID), Sina Bavari (USAMRIID), and Robert Dams (University of Pennsylvania) for generous gifts of plasmids and Shinji Makino (University of Texas Medical Branch) for providing the MP12rLuc virus. We also wish to thank Neal Satterly for useful discussions of results. The research was performed while Anna Maria Copeland held a National Academy of Sciences National Research Council Associateship, which was funded by the Joint Sciences and Technology Office of the US Defense Threat Reduction Agency. Opinions, interpretations, conclusions, and recommendations are ours and are not necessarily endorsed by the U.S. Army or Department of Defense. NR 28 TC 2 Z9 2 U1 2 U2 3 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD DEC PY 2015 VL 486 BP 88 EP 93 DI 10.1016/j.virol.2015.09.003 PG 6 WC Virology SC Virology GA CY2HQ UT WOS:000366229800013 PM 26410240 ER PT J AU Knox, RW Demons, ST Cunningham, CW AF Knox, Randy W. Demons, Samandra T. Cunningham, Cord W. TI A Novel Method to Decontaminate Surgical Instruments for Operational and Austere Environments SO WILDERNESS & ENVIRONMENTAL MEDICINE LA English DT Article DE austere; operational; emergency; life-saving interventions; field equipment sterilization ID RADIATION; CARE AB Objective.-The purpose of this investigation was to test a field-expedient, cost-effective method to decontaminate, sterilize, and package surgical instruments in an operational (combat) or austere environment using chlorhexidine sponges, ultraviolet C (UVC) light, and commercially available vacuum sealing. Methods.-This was a bench study of 4 experimental groups and 1 control group of 120 surgical instruments. Experimental groups were inoculated with a 106 concentration of common wound bacteria. The control group was vacuum sealed without inoculum. Groups 1, 2, and 3 were first scrubbed with a chlorhexidine sponge, rinsed, and dried. Group 1 was then packaged; group 2 was irradiated with UVC light, then packaged; group 3 was packaged, then irradiated with UVC light through the bag; and group 4 was packaged without chlorhexidine scrubbing or UVC irradiation. The UVC was not tested by itself, as it does not grossly clean. The instruments were stored overnight and tested for remaining colony forming units (CFU). Results.-Data analysis was conducted using analysis of variance and group comparisons using the Tukey method. Group 4 CFU was statistically greater (P<.001) than the control group and groups 1 through 3. There was no statistically significant difference between the control group and groups 1 through 3. Conclusions.-Vacuum sealing of chlorhexidine-scrubbed contaminated instruments with and without handheld UVC irradiation appears to be an acceptable method of field decontamination. Chlorhexidine scrubbing alone achieved a 99.9% reduction in CFU, whereas adding UVC before packaging achieved sterilization or 100% reduction in CFU, and UVC through the bag achieved disinfection. C1 [Knox, Randy W.] William Beaumont Army Med Ctr, Emergency Med Physician Assistant Residency, Ft Bliss, TX USA. [Knox, Randy W.] William Beaumont Army Med Ctr, Dept Emergency Med, Ft Bliss, TX USA. [Demons, Samandra T.] United States Army Med Res Inst Infect Dis, Ft Detrick, MD USA. [Cunningham, Cord W.] San Antonio Mil Med Ctr, EMS & Disaster Med Fellowship, Joint Base San Antonio, TX USA. [Cunningham, Cord W.] San Antonio Mil Med Ctr, Dept Emergency Med, Joint Base San Antonio, TX 78234 USA. RP Cunningham, CW (reprint author), San Antonio Mil Med Ctr, Dept Emergency Med, Bldg 3851,Roger Brooke Dr, Joint Base San Antonio, TX 78234 USA. EM c4.cunningham@gmail.com NR 5 TC 0 Z9 0 U1 2 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1080-6032 EI 1545-1534 J9 WILD ENVIRON MED JI Wildern. Environ. Med. PD DEC PY 2015 VL 26 IS 4 BP 509 EP 513 PG 5 WC Public, Environmental & Occupational Health; Sport Sciences SC Public, Environmental & Occupational Health; Sport Sciences GA CY2HA UT WOS:000366228200008 PM 26165581 ER PT J AU Pidcoke, HF Cap, AP AF Pidcoke, Heather F. Cap, Andrew P. TI Refrigerated Platelets for the Treatment of Acute Bleeding: A Review of the Literature and Reexamination of Current Standards: Reply SO SHOCK LA English DT Letter C1 [Pidcoke, Heather F.; Cap, Andrew P.] US Army Inst Surg Res, JBSA Ft Sam Houston, San Antonio, TX 78234 USA. RP Pidcoke, HF (reprint author), US Army Inst Surg Res, JBSA Ft Sam Houston, San Antonio, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD DEC PY 2015 VL 44 IS 6 BP 616 EP 617 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA CX4LZ UT WOS:000365673700016 PM 26565705 ER PT J AU Recchia, S Zheng, JQ Horner, S Pelegri, AA AF Recchia, Stephen Zheng, James Q. Horner, Suzanne Pelegri, Assimina A. TI Multiscale modeling of randomly interwoven fibers for prediction of KM2 Kevlar yarn strength and damage SO ACTA MECHANICA LA English DT Article ID REPRESENTATIVE VOLUME ELEMENT; COMPOSITES AB Modeling Kevlar yarn response as a function of twist requires creating a model at the filament level that incorporates capturing the mechanical interaction of numerous fibers. The inherent complexity of building a multiscale interwoven fibrous structure manually is prohibitive for such an endeavor; therefore, computer-aided simulations are preferred. In this study, a random walk methodology was employed to generate a fibrous structure along the axis of a yarn. Since the directionality of the fibers is randomly oriented along the axis, the fibers can wind around each other and tangle or terminate on demand. The resultant geometry can represent the tortuous path that yarn filaments experience. Yarn twist can be introduced through imposing a rotation matrix to the geometry or conducting an initial analysis that applies the preload. The analysis method employed in this paper captures the correct prestress of the twisted yarns at zero, three, and ten twists per inch. The analysis then loaded the yarn until filament fracture occurred. The predicted ultimate load was within 5% for all three twists per inch analyzed. The zero twists per inch linear response matched test results to within 5%. C1 [Recchia, Stephen] Rutgers State Univ, Sch Engn, Adv Mat & Struct Lab, Piscataway, NJ 08854 USA. [Zheng, James Q.; Horner, Suzanne] US Army, Program Execut Off Soldier, Ft Belvoir, VA 22060 USA. [Pelegri, Assimina A.] Rutgers State Univ, Sch Engn, Dept Mech & Aerosp Engn, Piscataway, NJ 08854 USA. RP Pelegri, AA (reprint author), Rutgers State Univ, Sch Engn, Dept Mech & Aerosp Engn, 98 Brett Rd, Piscataway, NJ 08854 USA. EM pelegri@jove.rutgers.edu FU United States Army [W91CRB-12-P-0047 P00003] FX The authors kindly acknowledge the financial support PEO-Soldier of the United States Army Contract W91CRB-12-P-0047 P00003 to perform this research. NR 26 TC 1 Z9 1 U1 3 U2 9 PU SPRINGER WIEN PI WIEN PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA SN 0001-5970 EI 1619-6937 J9 ACTA MECH JI Acta Mech. PD DEC PY 2015 VL 226 IS 12 BP 4149 EP 4158 DI 10.1007/s00707-015-1486-0 PG 10 WC Mechanics SC Mechanics GA CX2GB UT WOS:000365513500015 ER PT J AU Walsh, DV Jurek, GM Capo-Aponte, JE Riggs, DW Ramiccio, JA AF Walsh, David V. Jurek, Gina M. Capo-Aponte, Jose E. Riggs, Daniel W. Ramiccio, John A. TI Assessment of an Alternative Army Aircrew Eyewear SO AEROSPACE MEDICINE AND HUMAN PERFORMANCE LA English DT Article DE aviator spectacles; aircrew flight frame operational style; military; vision correction AB BACKGROUND: Currently, Army aircrews needing refractive correction are issued the HGU-4/P aviator spectacles. However, a recently published survey found dissatisfaction with the current spectacle frame. The Aircrew Flight Frame (AFF) has been used by the Air Force for over 14 yr, with the AFF-OP (Operational) style used the longest. The purpose of this study was to evaluate AFF-OP performance and compatibility among U.S. Army aircrew under operational conditions. METHODS: At 1-, 6-, and 12-wk intervals, 73 Army aircrew members wore the AFF-OP eyewear and completed a Likert scale survey. There were 14 outcome measures surveyed, with the main outcome measure being frame preference. RESULTS: The AFF-OP was preferred significantly more than the HGV-4/P spectacle. Overall, 94% of aircrew responses preferred the AFF-OP and the three highest subjective reasons for AFF-OP preference were: 1) comfort around the ears without helmet or headset; 2) comfort around the ears with helmet or headset; and 3) the effect on ear cup seal. There were no statistically significant differences in responses over the three surveyed time intervals. DISCUSSION: Army aviation aircrew preferred the AFF-OP over the current HGU-4/P spectacles. Two of the top three highest subjective reasons for AFF-OP preference coincided with two of the top three operational eyewear problems reported in the recently published survey. If Army aircrew do not wear their issued eyewear, they may purchase their own frame "out of pocket." However, this can lead to use of a frame that has not been tested for compatibility and may compromise performance of aircrew life support equipment. C1 [Walsh, David V.] US Army Aeromed Res Lab, Ft Rucker, AL 36362 USA. Womack Army Med Ctr, Ft Bragg, NC USA. RP Walsh, DV (reprint author), US Army Aeromed Res Lab, Vis Protect & Performance Div, 6901 Farrel Rd, Ft Rucker, AL 36362 USA. EM david.v.walsh.mil@mail.mil FU Military Operational Medicine Research Program of the U.S. Army Medical Research and Materiel Command FX This research was funded by the Military Operational Medicine Research Program of the U.S. Army Medical Research and Materiel Command. It was sponsored in part by the appointment to the Postgraduate Research Participation Program at the U.S. Army Aeromedical Research Laboratory administered by the Oak Ridge Institute of Science and Education through an interagency agreement the U.S. Department of Energy and U.S. Army Medical Research Material Command. Finally, the authors thank the Naval Ophthalmic Support and Training Activity laboratory for supplying the frames and lenses in support of the research. NR 11 TC 1 Z9 1 U1 0 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 2375-6314 EI 2375-6322 J9 AEROSP MED HUM PERF JI Aerosp. Med.Hum. Perform. PD DEC PY 2015 VL 86 IS 12 BP 1014 EP 1019 DI 10.3357/AMHP.4361.2015 PG 6 WC Biophysics; Public, Environmental & Occupational Health; Medicine, Research & Experimental SC Biophysics; Public, Environmental & Occupational Health; Research & Experimental Medicine GA CX6UZ UT WOS:000365838500002 PM 26630047 ER PT J AU Naim, R Abend, R Wald, I Eldar, S Levi, O Fruchter, E Ginat, K Halpern, P Sipos, ML Adler, AB Bliese, PD Quartana, PJ Pine, DS Bar-Haim, Y AF Naim, Reut Abend, Rany Wald, Ilan Eldar, Sharon Levi, Ofir Fruchter, Eyal Ginat, Karen Halpern, Pinchas Sipos, Maurice L. Adler, Amy B. Bliese, Paul D. Quartana, Phillip J. Pine, Daniel S. Bar-Haim, Yair TI Threat-Related Attention Bias Variability and Posttraumatic Stress SO AMERICAN JOURNAL OF PSYCHIATRY LA English DT Article ID ANXIETY DISORDERS; PTSD; AMYGDALA; CHILDREN; METAANALYSIS; SYMPTOMS; FEAR; ADOLESCENTS; SPECIFICITY; DYSFUNCTION AB Objective: Threat monitoring facilitates survival by allowing one to efficiently and accurately detect potential threats. Traumatic events can disrupt healthy threat monitoring, inducing biased and unstable threat-related attention deployment. Recent research suggests that greater attention bias variability, that is, attention fluctuations alternating toward and away from threat, occurs in participants with PTSD relative to healthy comparison subjects who were either exposed or not exposed to traumatic events. The current study extends findings on attention bias variability in PTSD Method: Previous measurement of attention bias variability was refined by employing a moving average technique. Analyses were conducted across seven independent data sets; in each, data on attention bias variability were collected by using variants of the dot-probe task. Trauma-related and anxiety symptoms were evaluated across samples by using structured psychiatric interviews and widely used self-report questionnaires, as specified for each sample. Results: Analyses revealed consistent evidence of greater attention bias variability in patients with PTSD following various types of traumatic events than in healthy participants, participants with social anxiety disorder, and participants with acute stress disorder. Moreover, threat-related, and not positive, attention bias variability was correlated with PTSD severity. Conclusions: These findings carry possibilities for using attention bias variability as a specific cognitive marker of PTSD and for tailoring protocols for attention bias modification for this disorder. C1 [Naim, Reut] Tel Aviv Univ, Sagol Sch Neurosci, Sch Psychol Sci, IL-69978 Tel Aviv, Israel. Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel. Israel Def Forces, Med Corps, Div Mental Hlth, Jerusalem, Israel. Tel Aviv Med Ctr & Sch Med, Emergency Dept, Tel Aviv, Israel. US Army Med Res & Mat Command, Ctr Mil Psychiat & Neurosci, Walter Reed Army Inst Res, Silver Spring, MD USA. Univ S Carolina, Darla Moore Sch Business, Columbia, SC 29208 USA. NIMH, Intramural Res Program, Bethesda, MD 20892 USA. RP Naim, R (reprint author), Tel Aviv Univ, Sagol Sch Neurosci, Sch Psychol Sci, IL-69978 Tel Aviv, Israel. EM reutnaim@post.tau.ac.il NR 50 TC 13 Z9 13 U1 9 U2 25 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 0002-953X EI 1535-7228 J9 AM J PSYCHIAT JI Am. J. Psychiat. PD DEC PY 2015 VL 172 IS 12 BP 1242 EP 1250 DI 10.1176/appi.ajp.2015.14121579 PG 9 WC Psychiatry SC Psychiatry GA CX6UJ UT WOS:000365836900012 PM 26206076 ER PT J AU Farooq, F Bergmann-Leitner, ES AF Farooq, Fouzia Bergmann-Leitner, Elke S. TI Immune Escape Mechanisms are Plasmodium's Secret Weapons Foiling the Success of Potent and Persistently Efficacious Malaria Vaccines SO CLINICAL IMMUNOLOGY LA English DT Article DE Malaria; Immune escape; Immune editing; Vaccine ID REGULATORY T-CELLS; FALCIPARUM-INFECTED ERYTHROCYTES; CIRCUMSPOROZOITE PROTEIN; HUMAN VOLUNTEERS; DENDRITIC CELLS; STAGE MALARIA; IN-VIVO; PARASITE; SPOROZOITES; COMPLEMENT AB Despite decades of active research, an efficacious vaccine mediating long-term protection is still not available. This review highlights various mechanisms and the different facets by which the parasites outsmart the immune system. An understanding of how the parasites escape immune recognition and interfere with the induction of a protective immune response that provides sterilizing immunity will be crucial to vaccine design. Published by Elsevier Inc. C1 [Farooq, Fouzia; Bergmann-Leitner, Elke S.] Walter Reed Army Inst Res, Malaria Vaccine Branch, US Mil Malaria Res Program, Silver Spring, MD 20910 USA. RP Bergmann-Leitner, ES (reprint author), Walter Reed Army Inst Res, Malaria Vaccine Branch, US Mil Malaria Res Program, Silver Spring, MD 20910 USA. EM elke.s.bergmannleitner.civ@mail.mil NR 69 TC 2 Z9 2 U1 1 U2 4 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1521-6616 EI 1521-7035 J9 CLIN IMMUNOL JI Clin. Immunol. PD DEC PY 2015 VL 161 IS 2 BP 136 EP 143 DI 10.1016/j.clim.2015.08.015 PG 8 WC Immunology SC Immunology GA CX6SL UT WOS:000365831600011 PM 26342537 ER PT J AU Laxminarayan, S Reifman, J Edwards, SS Wolpert, H Steil, GM AF Laxminarayan, Srinivas Reifman, Jaques Edwards, Stephanie S. Wolpert, Howard Steil, Garry M. TI Bolus Estimation-Rethinking the Effect of Meal Fat Content SO DIABETES TECHNOLOGY & THERAPEUTICS LA English DT Article ID TYPE-1 DIABETES IMPLICATIONS; INCREASES GLUCOSE-CONCENTRATIONS; INSULIN REQUIREMENTS; DOSE CALCULATION; SENSITIVITY; MANAGEMENT; PROTEIN; OUTPUT; PUMP AB Background: Traditionally, insulin bolus calculations for managing postprandial glucose levels in individuals with type 1 diabetes rely solely on the carbohydrate content of a meal. However, recent studies have reported that other macronutrients in a meal can alter the insulin required for good postprandial control. Specifically, studies have shown that high-fat (HF) meals require more insulin than low-fat (LF) meals with identical carbohydrate content. Our objective was to assess the mechanisms underlying the higher insulin requirement observed in one of these studies. Materials and Methods: We used a combination of previously validated metabolic models to fit data from a study comparing HF and LF dinners with identical carbohydrate content in seven subjects with type 1 diabetes. For each subject and dinner type, we estimated the model parameters representing the time of peak meal-glucose appearance ((m)), insulin sensitivity (S-I), the net hepatic glucose balance, and the glucose effect at zero insulin in four time windows (dinner, early night, late night, and breakfast) and assessed the differences in model parameters via paired Wilcoxon signed-rank tests. Results: During the HF meal, the (m) was significantly delayed (mean and standard error [SE]: 102 [14] min vs. 71 [4] min; P=0.02), and S-I was significantly lower (7.25x10(-4) [1.29x10(-4)] mL/U/min vs. 8.72x10(-4) [1.08x10(-4)] mL/U/min; P=0.02). Conclusions: In addition to considering the putative delay in gastric emptying associated with HF meals, we suggest that clinicians reviewing patient records consider that the fat content of these meals may alter S-I. C1 [Laxminarayan, Srinivas; Reifman, Jaques] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Dept Def, Biotechnol High Performance Comp Software Applica, Ft Detrick, MD USA. [Edwards, Stephanie S.; Wolpert, Howard] Joslin Diabet Ctr, Boston, MA 02215 USA. [Wolpert, Howard; Steil, Garry M.] Harvard Univ, Sch Med, Boston, MA USA. [Steil, Garry M.] Childrens Hosp, Boston, MA 02115 USA. RP Steil, GM (reprint author), Childrens Hosp Boston, ATTN Div Med Crit Care, 333 Longwood Ave, Boston, MA 02215 USA. EM garry.steil@childrens.harvard.edu FU U.S. Department of Defense [W81XWH-11-1-0421]; Military Operational Medicine Research Area Directorate of the U.S. Army Medical Research and Materiel Command, Fort Detrick, MD FX The study was supported by U.S. Department of Defense grant W81XWH-11-1-0421 to G.M.S. and by the Military Operational Medicine Research Area Directorate of the U.S. Army Medical Research and Materiel Command, Fort Detrick, MD, to S.L. and J.R. NR 22 TC 4 Z9 4 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1520-9156 EI 1557-8593 J9 DIABETES TECHNOL THE JI Diabetes Technol. Ther. PD DEC 1 PY 2015 VL 17 IS 12 BP 860 EP 866 DI 10.1089/dia.2015.0118 PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA CX4DB UT WOS:000365647500004 PM 26270134 ER PT J AU Adams, BL Stratis-Cullum, DN AF Adams, Bryn L. Stratis-Cullum, Dimitra N. TI Selective preference of engineered peptides for aluminum alloy SO EMERGING MATERIALS RESEARCH LA English DT Article DE biomaterials; biomolecules; hybrid materials and structures ID PHAGE DISPLAY; BINDING PEPTIDE; SPECIFICITY; AFFINITY; SURFACES; IDENTIFICATION; POLYPEPTIDES; RECOGNITION; DESIGN; OXIDE AB Bacterial cell surface display technology offers a powerful tool for the discovery and study of peptide-material interactions offering the potential toward tailoring the interaction and tuning the properties of multicomponent materials for future military and commercial systems. With bacterial cell surface display technology, a large diverse library containing billions of peptide material variants is encoded directly into the bacterial DNA, resulting in a self-sustaining and replicating population that can easily be propagated without requiring elution from the target. Recently, this method was extended to genetically engineered peptides for inorganics: specifically to a bulk aluminum alloy. In this paper, we further investigate the binding interaction of this peptide material including a study of relative binding to aluminum, glass, copper and brass. The surface display peptide exhibited more than 2 order of magnitude greater binding to the aluminum alloy compared to the glass sample, and little to no interaction with copper and brass. These results highlight, for the first time, the potential for selection interaction of genetically engineered peptides using the eCPX construct with inorganic materials and open the possibility for biohybrid materials and systems of the future. C1 [Adams, Bryn L.; Stratis-Cullum, Dimitra N.] US Army Res Lab, Adelphi, MD USA. RP Stratis-Cullum, DN (reprint author), US Army Res Lab, Adelphi, MD USA. EM dimitra.n.stratis-cullum.civ@mail.mil FU US Army Research Laboratory Postdoctoral Fellowship Program FX This project is supported in part by appointments to the US Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through a contract with the US Army Research Laboratory. NR 42 TC 1 Z9 1 U1 3 U2 15 PU ICE PUBLISHING PI WESTMINISTER PA INST CIVIL ENGINEERS, 1 GREAT GEORGE ST, WESTMINISTER SW 1P 3AA, ENGLAND SN 2046-0147 EI 2046-0155 J9 EMERG MATER RES JI Emerg. Mater. Res. PD DEC PY 2015 VL 4 IS 2 BP 218 EP 222 DI 10.1680/emr.15.00028 PG 5 WC Materials Science, Multidisciplinary SC Materials Science GA CX5DA UT WOS:000365720600009 ER PT J AU Hulla, JE Sahu, SC Hayes, AW AF Hulla, J. E. Sahu, S. C. Hayes, A. W. TI Nanotechnology: History and future SO HUMAN & EXPERIMENTAL TOXICOLOGY LA English DT Article ID NANOSCALE MATERIALS; RESEARCH STRATEGIES; SAFETY EVALUATION; NANOPARTICLES; NANOMATERIALS; DELIVERY; CANCER C1 [Hulla, J. E.] US Army Corps Engn, Sacramento, CA USA. [Sahu, S. C.] US FDA, Div Toxicol, Off Appl Res & Safety Assessment, Ctr Food Safety & Appl Nutr, Laurel, MD USA. [Hayes, A. W.] Harvard Univ, Cambridge, MA 02138 USA. RP Hayes, AW (reprint author), Harvard Univ, Cambridge, MA 02138 USA. EM awallacehayes@comcast.net NR 30 TC 2 Z9 2 U1 10 U2 35 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0960-3271 EI 1477-0903 J9 HUM EXP TOXICOL JI Hum. Exp. Toxicol. PD DEC PY 2015 VL 34 IS 12 BP 1318 EP 1321 DI 10.1177/0960327115603588 PG 4 WC Toxicology SC Toxicology GA CX5ME UT WOS:000365745000017 PM 26614822 ER PT J AU Zhang, NY Ho, J Runt, J Zhang, SH AF Zhang, Nanyan Ho, Janet Runt, James Zhang, Shihai TI Light weight high temperature polymer film capacitors with dielectric loss lower than polypropylene SO JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS LA English DT Article ID ENERGY-STORAGE CAPACITORS; RELAXATION AB The dielectric and high voltage performance of polymethylpentene (PMP) is investigated and compared with biaxially-oriented polypropylene (BOPP) for high power density and high temperature capacitor applications. PMP has a melting temperature that is around 60 A degrees C higher than BOPP, while still maintaining low dielectric loss and high charge-discharge efficiency that are comparable to the latter. Furthermore, PMP is the lightest commercial thermoplastic polymer with density of 0.83 g/cm(3), which is 8 % lower than BOPP (0.9 g/cm(3)). PMP is a promising semicrystalline dielectric material that may replace BOPP for high temperature pulsed power and power conditioning applications. C1 [Zhang, Nanyan; Zhang, Shihai] PolyK Technol LLC, State Coll, PA 16801 USA. [Ho, Janet] US Army, Res Lab, Adelphi, MD 20783 USA. [Runt, James] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. RP Ho, J (reprint author), US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM janet.s.ho.civ@mail.mil; energy@polyktech.com FU U.S. Office of Naval Research [N00014-13C0234] FX This work was supported by the U.S. Office of Naval Research under contract number N00014-13C0234. NR 31 TC 2 Z9 2 U1 3 U2 22 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0957-4522 EI 1573-482X J9 J MATER SCI-MATER EL JI J. Mater. Sci.-Mater. Electron. PD DEC PY 2015 VL 26 IS 12 SI SI BP 9396 EP 9401 DI 10.1007/s10854-015-3152-7 PG 6 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Engineering; Materials Science; Physics GA CX2KP UT WOS:000365525900020 ER PT J AU Darling, KA Kapoor, M Kotan, H Hornbuckle, BC Walck, SD Thompson, GB Tschopp, MA Kecskes, LJ AF Darling, K. A. Kapoor, M. Kotan, H. Hornbuckle, B. C. Walck, S. D. Thompson, G. B. Tschopp, M. A. Kecskes, L. J. TI Structure and mechanical properties of Fe-Ni-Zr oxide-dispersion-strengthened (ODS) alloys SO JOURNAL OF NUCLEAR MATERIALS LA English DT Article DE Mechanical properties; Oxide-dispersion-strengthening; Atom probe tomography; Fe based ODS alloys; Zirconium-oxide ID NANOSTRUCTURED FERRITIC ALLOYS; HIGH-TEMPERATURE SYNTHESIS; 3-DIMENSIONAL ATOM-PROBE; THERMAL-STABILITY; PHASE-TRANSFORMATION; STEELS; PARTICLES; NANOCLUSTERS; DEFORMATION; IRRADIATION AB A series of bulk nanostructured Fe-Ni-Zr oxide-dispersion-strengthened (ODS) alloys were synthesized using high energy mechanical alloying and consolidated using high temperature equal channel angular extrusion. The resultant microstructures are composed of nano/ultrafine or micrometer-sized grains with larger intermetallic precipitates and small Zr oxide clusters (<10 nm diameter, measured and confirmed by atom probe tomography). The ODS alloys possess elevated compression properties, e.g., 1.2 and 2.4 GPa compressive yield stress at room temperature for samples consolidated at 700 degrees C and 1000 degrees C, respectively. This work highlights the relationship between processing, microstructure, and properties for this class of ferritic ODS alloys. Published by Elsevier B.V. C1 [Darling, K. A.; Hornbuckle, B. C.; Walck, S. D.; Tschopp, M. A.; Kecskes, L. J.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Kapoor, M.; Thompson, G. B.] Univ Alabama, Dept Met & Mat Engn, Tuscaloosa, AL 35487 USA. [Kotan, H.] Necmettin Erbakan Univ, Dept Met & Mat Engn, TR-42090 Konya, Turkey. RP Darling, KA (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM Kristopher.darling.civ@mail.mil RI Tschopp, Mark/B-1594-2008 OI Tschopp, Mark/0000-0001-8471-5035 FU Sandia National Laboratories through the Department of Energy Office of Basic Energy Sciences FX M. Kapoor and G.B. Thompson gratefully acknowledge support from Sandia National Laboratories through the Department of Energy Office of Basic Energy Sciences. NR 63 TC 2 Z9 2 U1 5 U2 21 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-3115 EI 1873-4820 J9 J NUCL MATER JI J. Nucl. Mater. PD DEC PY 2015 VL 467 BP 205 EP 213 DI 10.1016/j.jnucmat.2015.09.011 PN 1 PG 9 WC Materials Science, Multidisciplinary; Nuclear Science & Technology SC Materials Science; Nuclear Science & Technology GA CX3MJ UT WOS:000365602800021 ER PT J AU Hayman, WR Leuthner, SR Laventhal, NT Brousseau, DC Lagatta, JM AF Hayman, W. R. Leuthner, S. R. Laventhal, N. T. Brousseau, D. C. Lagatta, J. M. TI Cost comparison of mechanically ventilated patients across the age span SO JOURNAL OF PERINATOLOGY LA English DT Article ID EXTREMELY PRETERM INFANTS; CRITICAL-CARE MEDICINE; LONG-TERM OUTCOMES; HOME OXYGEN USE; INTENSIVE-CARE; UNITED-STATES; CARDIOPULMONARY-RESUSCITATION; SEVERE SEPSIS; BED NUMBERS; EPIDEMIOLOGY AB OBJECTIVE: To compare the use of mechanical ventilation and hospital costs across ventilated patients of all ages, preterm through adults, in a nationally representative sample. STUDY DESIGN: Secondary analysis of the 2009 Agency for Healthcare Research and Quality National Inpatient Sample. RESULTS: A total of 1 107 563 (2.8%) patients received mechanical ventilation. For surviving ventilated patients, median costs for infants <= 32 weeks' gestation were $51000 to $209 000, whereas median costs for older patients were lower from $17000 to $25 000. For non-surviving ventilated patients, median costs were $27 000 to $39 000 except at the extremes of age; the median cost was $10000 for <24 week newborns and $14000 for 91+ year adults. Newborns of all gestational ages had a disproportionate share of hospital costs relative to their total volume. CONCLUSION: Most intensive care unit resources at the extremes of age are not directed toward non-surviving patients. From a perinatal perspective, attention should be directed toward improving outcomes and reducing costs for all infants, not just at the earliest gestational ages. C1 [Hayman, W. R.] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. [Leuthner, S. R.; Brousseau, D. C.; Lagatta, J. M.] Med Coll Wisconsin, Dept Pediat, Milwaukee, WI 53226 USA. [Laventhal, N. T.] Univ Michigan, Dept Pediat & Communicable Dis, Ann Arbor, MI 48109 USA. RP Lagatta, JM (reprint author), Med Coll Wisconsin, Dept Pediat, 999 N,92nd St,Suite C410, Milwaukee, WI 53226 USA. EM jlagatta@mcw.edu FU National Center for Advancing Translational Sciences, National Institutes of Health [8UL1TR000055] FX This study was partially supported by the National Center for Advancing Translational Sciences, National Institutes of Health through Grant Number 8UL1TR000055. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. NR 39 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0743-8346 EI 1476-5543 J9 J PERINATOL JI J. Perinatol. PD DEC PY 2015 VL 35 IS 12 BP 1020 EP 1026 DI 10.1038/jp.2015.131 PG 7 WC Obstetrics & Gynecology; Pediatrics SC Obstetrics & Gynecology; Pediatrics GA CX2XB UT WOS:000365559000010 PM 26468935 ER PT J AU Hydren, JR Cohen, BS AF Hydren, Jay R. Cohen, Bruce S. TI CURRENT SCIENTIFIC EVIDENCE FOR A POLARIZED CARDIOVASCULAR ENDURANCE TRAINING MODEL SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Review DE threshold; high-intensity interval training; high volume training; V; o(2)max; blood lactate; periodization ID HEART-RATE-VARIABILITY; INTENSITY DISTRIBUTION; OVERTRAINING SYNDROME; SPEED SKATERS; PERFORMANCE; THRESHOLD; RUNNERS; IMPACT; CYCLISTS AB Hydren, JR and Cohen, BS. Current scientific evidence for a polarized cardiovascular endurance training model. J Strength Cond Res 29(12): 3523-3530, 2015Recent publications have provided new scientific evidence for a modern aerobic or cardiovascular endurance exercise prescription that optimizes the periodization cycle and maximizes potential endurance performance gains in highly trained individuals. The traditional threshold, high volume, and high-intensity training models have displayed limited improvement in actual race pace in (highly) trained individuals while frequently resulting in overreaching or overtraining (physical injury and psychological burnout). A review of evidence for replacing these models with the proven polarized training model seems warranted. This review provides a short history of the training models, summarizes 5 key studies, and provides example training programs for both the pre- and in-season periods. A polarized training program is characterized by an undulating nonlinear periodization model with nearly all the training time spent at a light (13) and very hard (17) pace with very limited time at hard (14-16) or race pace (6-20 Rating of Perceived Exertion [RPE] scale). To accomplish this, the polarization training model has specific high-intensity workouts separated by one or more long slow distance workouts, with the exercise intensity remaining below ventilatory threshold (VT) 1 and/or blood lactate of less than 2 mM (A.K.A. below race pace). Effect sizes for increasing aerobic endurance performance for the polarized training model are consistently superior to that of the threshold training model. Performing a polarized training program may be best accomplished by: going easy on long slow distance workouts, avoiding race pace and getting after it during interval workouts. C1 [Hydren, Jay R.; Cohen, Bruce S.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA USA. RP Hydren, JR (reprint author), US Army Res Inst Environm Med, Mil Performance Div, Natick, MA USA. EM jayhydren@gmail.com RI Hydren, Jay/H-3654-2016 OI Hydren, Jay/0000-0001-9385-8898 NR 24 TC 0 Z9 0 U1 32 U2 42 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1064-8011 EI 1533-4287 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD DEC PY 2015 VL 29 IS 12 BP 3523 EP 3530 DI 10.1519/JSC.0000000000001197 PG 8 WC Sport Sciences SC Sport Sciences GA CX4ZY UT WOS:000365710900034 PM 26595137 ER PT J AU McKay, SK AF McKay, S. Kyle TI Quantifying Tradeoffs Associated with Hydrologic Environmental Flow Methods SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article DE environmental flows; instream flows; minimum flows; sustainability boundaries; tradeoffs; Middle Oconee River ID UNITED-STATES; FRESH-WATER; RIVER; ECOSYSTEMS; MANAGEMENT; RULES; GEORGIA; REGIMES; NEEDS AB Freshwater management requires balancing and tradingoff multiple objectives, many of which may be competing. Ecological needs for freshwater are often described in terms of environmental flow recommendations (e.g., minimum flows), and there are many techniques for developing these recommendations, which range from hydrologic rules to multidisciplinary analyses supported by large teams of subject matter experts. Although hydrologic rules are well acknowledged as overly simplified, these techniques remain the state-of-the-practice in many locations. This article seeks to add complexity to the application of these techniques by studying the emergent properties of hydrologic environmental flow methodologies. Two hydrologic rules are applied: minimum flow criteria and sustainability boundaries. Objectives and metrics associated with withdrawal rate and similarity to natural flow regimes are used to tradeoff economic and environmental needs, respectively, over a range of flow thresholds and value judgments. A case study of hypothetical water withdrawals on the Middle Oconee River near Athens, Georgia is applied to demonstrate these techniques. For this case study, sustainability boundaries emerge as preferable relative to both environmental and economic outcomes. Methods applied here provide a mechanism for examining the role of stakeholder values and tradeoffs in application of hydrologic rules for environmental flows. C1 [McKay, S. Kyle] US Army, Engn Res & Dev Ctr, Environm Lab, Athens, GA 30339 USA. RP McKay, SK (reprint author), US Army, Engn Res & Dev Ctr, Environm Lab, 248 Georgia Ave, Athens, GA 30339 USA. EM kyle.mckay@usace.army.mil FU U.S. Army Corps of Engineers through the Ecosystem Management and Restoration Research Program FX The U.S. Army Corps of Engineers funded this research through the Ecosystem Management and Restoration Research Program (http://www.el.erdc.usace.army.mil/emrrp/). The opinions reflected here are those of the author and do not necessarily reflect those of the agency. A prior draft was significantly improved from comments by Alan Covich, Mary Freeman, Rhett Jackson, Bobby McComas, Bruce Pruitt, and John Schramski. NR 56 TC 0 Z9 0 U1 3 U2 15 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1093-474X EI 1752-1688 J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD DEC PY 2015 VL 51 IS 6 BP 1508 EP 1518 DI 10.1111/1752-1688.12328 PG 11 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA CX6FX UT WOS:000365797700003 ER PT J AU Park, TS Batchinsky, AI Belenkiy, SM Jordan, BS Baker, WL Necsoiu, CN Aden, JK Dubick, MA Cancio, LC AF Park, Timothy S. Batchinsky, Andriy I. Belenkiy, Slava M. Jordan, Bryan S. Baker, William L. Necsoiu, Corina N. Aden, James K. Dubick, Michael A. Cancio, Leopoldo C. TI Resuscitative endovascular balloon occlusion of the aorta (REBOA): Comparison with immediate transfusion following massive hemorrhage in swine SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article; Proceedings Paper CT 45th Annual Meeting of the Western-Trauma-Association CY MAR 01-06, 2015 CL Telluride, CO SP Western Trauma Assoc DE Swine; shock; hemorrhagic; aorta; endovascular procedures ID NONCOMPRESSIBLE TORSO HEMORRHAGE; UK COMBAT CASUALTIES; THORACOTOMY; MODEL; SHOCK; EMERGENCY; OUTCOMES; INJURY AB BACKGROUND Resuscitative endovascular balloon occlusion of the aorta (REBOA) is less invasive than emergency department thoracotomy for the treatment of massive hemorrhage. We evaluated the effects of REBOA on carotid blood flow (Q(carotid)) in a porcine model of massive hemorrhage. We hypothesized that REBOA restores Q(carotid) faster than reinfusion of blood. METHODS Spontaneously breathing sedated Sinclair pigs underwent exponential hemorrhage of 65% total blood volume in 1 hour. They were randomized into three groups. Positive control (PC, n = 7) underwent immediate transfusion of shed blood. REBOA (n = 21) received a novel 7 Fr ER-REBOA catheter (Pryor Medical, Arvada, CO) placed into aortic Zone 1 via a femoral artery introducer for 30 minutes or 60 minutes, with transfusion either after deflation or midway through inflation. Negative control (n = 7) received no resuscitation. Q(carotid) was recorded continuously using an ultrasonic flow probe. Survival and time between Q(carotid, min) and both a stable maximal value (Q(carotid, max)) and restoration of baseline flow (Q(carotid, new BL)) were compared by Kaplan-Meier analysis. RESULTS Median time to Q(carotid, max) was 3.0 minutes in the REBOA group versus 9.6 minutes in the control group (p = 0.006). Median time to Q(carotid, new BL) was 6.0 minutes in the REBOA group versus 20.5 minutes in the PC group (p = 0.11). Slope of the linear regression between Q(carotid, min) and Q(carotid, new BL) was 16.7 in REBOA and 10.4 in PC (p = 0.31). Four-hour survival was 95% (20 of 21) in the REBOA group versus 71% (5 of 7) in the PC group (p = 0.06) and 0% in the negative control group. CONCLUSION REBOA resulted in the restoration of Q(carotid) (cerebrovascular resuscitation) at least as rapidly as retransfusion of shed blood, with equivalent 4-hour survival. Further studies of REBOA, to include mitigation of end-organ effects and longer follow-up, are needed. C1 [Park, Timothy S.] San Antonio Mil Med Ctr, Gen Surg Serv, San Antonio, TX USA. [Batchinsky, Andriy I.; Belenkiy, Slava M.; Jordan, Bryan S.; Baker, William L.; Necsoiu, Corina N.; Aden, James K.; Dubick, Michael A.; Cancio, Leopoldo C.] US Army Inst Surg Res, JBSA Ft Sam Houston, San Antonio, TX USA. RP Cancio, LC (reprint author), JBSA Ft Sam Houston, 3698 Chambers Pass, San Antonio, TX USA. EM divego99@gmail.com FU Telemedicine and Advanced Technologies Research Center, Fort Detrick, MD; Pryor Medical; Geneva Foundation, Tacoma, WA; US Department of Energy; US Army Medical Research and Materiel Command FX This study was funded by a grant by the Telemedicine and Advanced Technologies Research Center, Fort Detrick, MD, to Pryor Medical, Inc., Arvada, CO, and via a subcontract between Pryor Medical and the Geneva Foundation, Tacoma, WA, for the work performed at the US Army Institute of Surgical Research. This research was also supported in part by the appointment of L.C.C. to the Knowledge Preservation Program at the US Army Institute of Surgical Research, administered by the Oak Ridge Institute for Science and Education, through an interagency agreement between the US Department of Energy and the US Army Medical Research and Materiel Command. NR 14 TC 6 Z9 6 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD DEC PY 2015 VL 79 IS 6 BP 930 EP 936 DI 10.1097/TA.0000000000000877 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA CX4TD UT WOS:000365692300009 PM 26680136 ER PT J AU Ernat, J Song, D Fazio, M Lindell, K Orchowski, J AF Ernat, Justin Song, Daniel Fazio, Michael Lindell, Kenneth Orchowski, Joseph TI Radiographic Changes and Fracture in Patients Having Received Bisphosphonate Therapy for >= 5 Years at a Single Institution SO MILITARY MEDICINE LA English DT Article ID FEMORAL-SHAFT FRACTURES; ALENDRONATE THERAPY; FEMUR; COMPLICATION; WOMEN; RISK; BONE AB Introduction: Bisphosphonates have been shown to reduce the incidence of vertebral fractures, as well as intertrochanteric and femoral neck fractures; however, data also demonstrate the association of prolonged use and atypical femur fractures. We intend to report the incidence of atypical femur fractures and cortical irregularities in patients from a single institution having received prolonged bisphosphonate therapy. Methods: A retrospective review of the pharmaceutical database was performed for all patients who were prescribed bisphosphonates at a single institution from 2002 to 2012. People taking bisphosphonates for >= 5 years were included. Those identified as having adequate radiographs with visualization of at least 5-cm distal to the lesser trochanter were selected. Radiographs were reviewed for evidence of atypical femur fractures or lateral cortical beaking. Medical records were retrospectively reviewed to determine any prodromal symptoms or clinical risk factors. Results: A total of 7,671 patients were identified between the years of 2002 and 2012 as having been prescribed bisphosphonates at a single institution. Of these, 1,684 were using bisphosphonates for >= 5 years (2002-2007). 396 patients taking bisphosphonates for greater than 5 years had adequate radiographs. In total, 8 patients (2.02%) had positive findings; 7 were females. More specifically, 2 (0.51%) patients had incomplete subtrochanteric fractures while 6 (1.52%) demonstrated lateral cortical beaking. Discussion/Conclusion: Over 2% of patients at our institution having received bisphosphonate therapy for >= 5 years demonstrated cortical irregularities or have already experienced an atypical femur fracture. These findings could call into question the need for radiographic screening for patients on prolonged bisphosphonate therapy. C1 [Ernat, Justin; Song, Daniel; Fazio, Michael; Lindell, Kenneth; Orchowski, Joseph] Tripler Army Med Ctr, Dept Orthoped Surg, Honolulu, HI 96859 USA. RP Ernat, J (reprint author), Tripler Army Med Ctr, Dept Orthoped Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 19 TC 2 Z9 2 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD DEC PY 2015 VL 180 IS 12 BP 1214 EP 1218 DI 10.7205/MILMED-D-14-00736 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA CX6ML UT WOS:000365815000013 PM 26633664 ER PT J AU Beals, K Darnell, ME Lovalekar, M Baker, RA Nagai, T San-Adams, T Wirt, MD AF Beals, Kim Darnell, Matthew E. Lovalekar, Mita Baker, Rachel A. Nagai, Takashi San-Adams, Thida Wirt, Michael D. TI Suboptimal Nutritional Characteristics in Male and Female Soldiers Compared to Sports Nutrition Guidelines SO MILITARY MEDICINE LA English DT Article ID HIGH-CARBOHYDRATE DIETS; EATING PATTERNS; PERFORMANCE; GARRISON; SUPPLEMENTATION; REQUIREMENTS; COMPETITION; FREQUENCY; ADEQUACY; RANGERS AB The purpose of this study was to evaluate the nutrient intake of male and female Soldiers in the 101st Airborne Division (Air Assault) compared to sports nutrition standards for athletes, and to identify suboptimal eating characteristics that may impair physical performance and jeopardize military readiness. Male and female Soldiers from the 101st Airborne Division (Air Assault) completed a 24-hour dietary recall and nutrition history questionnaire before anthropometric and body composition measurements were taken. Compared to sports nutrition guidelines, Soldiers of the 101st under consume carbohydrates (males: 3.9 +/- 2.0 vs. 5.0 g/kg, p < 0.001; females: 4.0 +/- 2.1 vs. 5.0 g/kg, p = 0.001), male Soldiers eat too much fat (32.4% of kcal vs. < 30% of kcal, p = 0.000) and saturated fat (males: 10.5 +/- 3.9% of kcal vs. 10.0% of kcal, p = 0.044), and both males and females follow a meal pattern that may not optimize energy availability throughout the day. Eating too much fat and under fueling carbohydrate may negatively impact the adaptations to physical training and compromise overall health. Although Soldiers continue to participate in arduous training programs, future research should be aimed at determining the energy and macronutrient needs to fuel and recover from specific types of military training. C1 [Beals, Kim; Darnell, Matthew E.; Lovalekar, Mita; Baker, Rachel A.; Nagai, Takashi; San-Adams, Thida] Univ Pittsburgh, Neuromuscular Res Lab, Dept Sports Med & Nutr, Pittsburgh, PA 15203 USA. [Wirt, Michael D.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA. RP Beals, K (reprint author), Univ Pittsburgh, Neuromuscular Res Lab, Dept Sports Med & Nutr, 3840 South Water St, Pittsburgh, PA 15203 USA. FU U.S. Army Medical Research and Materiel Command (Research grant USAMRMC/TATRC) [W81XWH-06-2-0070, W81XWH-09-2-0095, W81XWH-11-2-0097] FX This work was supported by the U.S. Army Medical Research and Materiel Command (Research grant USAMRMC/TATRC # W81XWH-06-2-0070/W81XWH-09-2-0095/W81XWH-11-2-0097). Opinions, interpretations, conclusions, and recommendations are those of the author and not necessarily endorsed by the U.S. Army. NR 50 TC 0 Z9 0 U1 2 U2 6 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD DEC PY 2015 VL 180 IS 12 BP 1239 EP 1246 DI 10.7205/MILMED-D-14-00515 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA CX6ML UT WOS:000365815000017 PM 26633668 ER PT J AU Boyle, EW AF Boyle, Eric W. TI The Surprising Origins of a World War II-Era Mural That Was Nearly Lost SO MILITARY MEDICINE LA English DT Editorial Material C1 [Boyle, Eric W.] US Army Med Res & Mat Command, Natl Museum Hlth & Med, Silver Spring, MD 20910 USA. RP Boyle, EW (reprint author), US Army Med Res & Mat Command, Natl Museum Hlth & Med, 2500 Linden Lane, Silver Spring, MD 20910 USA. NR 4 TC 0 Z9 0 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD DEC PY 2015 VL 180 IS 12 BP 1273 EP 1274 DI 10.7205/MILMED-D-15-00395 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA CX6ML UT WOS:000365815000022 PM 26633673 ER PT J AU Acevedo, JL Camacho, M Brietzke, SE AF Acevedo, Jason L. Camacho, Macario Brietzke, Scott E. TI Radiofrequency Ablation Turbinoplasty versus Microdebrider-Assisted Turbinoplasty: A Systematic Review and Meta-analysis SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Review DE turbinoplasty; turbinate reduction; systematic review; nasal congestion; allergic rhinitis ID INFERIOR TURBINATE HYPERTROPHY; PERENNIAL ALLERGIC RHINITIS; COMPUTED-TOMOGRAPHY; THERMAL ABLATION; FOLLOW-UP; REDUCTION; EFFICACY; AIRWAY; TRIAL; LASER AB Objective To critically review published literature for treatment-related outcomes for bilateral inferior turbinate reduction (IFTR) via either microdebrider-assisted turbinoplasty (MAT) or radiofrequency turbinoplasty. The primary outcomes were relief of nasal obstruction according to visual analog scale and nasal airflow, volume, and resistance measures based on acoustic rhinomanometry. Data Sources MEDLINE, EMBASE, The Cochrane Catalog, and CINAHL. Review Methods The databases were searched with the terms turbinoplasty and turbinate reduction. Inclusion criteria were English language, human subjects, and studies specifically relating to IFTR with radiofrequency turbinoplasty or MAT. Exclusion criteria were pediatric patients and concurrent nasal procedures. Results were tabulated, and the data were analyzed per random effects modeling. Subgroup analysis and quality assessment were also performed. Results A total of 976 articles were initially identified, with 26 meeting the inclusion/exclusion criteria. Random effects modeling demonstrated a significant improvement after IFTR, as measured with the visual analog scale (4.26-point improvement, 95% confidence interval [95% CI] = 3.32-5.20, P < .001, k = 21 studies, I-2 = 99%) and with acoustic rhinomanometry measurements of volume (2.43-cm(3) improvement, 95% CI = 0.48-4.38, P = .015, k = 6 studies, I-2 = 99%), flow (203-mL/s improvement, 95% CI = 131-276, P < .001, k = 4 studies, I-2 = 99%), and resistance change (2.78-Pa/cm(3) improvement, 95% CI = 0.433-5.13, P = .020, k = 5 studies, I-2 = 99%). There was no difference in outcome by technique, allergic rhinitis, or quality score. The 2 highest-quality papers favored MAT. The median follow-up was 6 months. Conclusions IFTR produces a significant subjective and objective improvement in nasal airflow in the short term. This change does not appear to be related to the technique used for IFTR. C1 [Acevedo, Jason L.] Reynolds Army Community Hosp, Ft Sill, OK USA. [Acevedo, Jason L.; Brietzke, Scott E.] Uniformed Serv Univ Hlth Sci, Bethesda, MD USA. [Camacho, Macario] Stanford Univ, Palo Alto, CA 94304 USA. [Brietzke, Scott E.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. RP Acevedo, JL (reprint author), Reynolds Army Community Hosp, 1665 Antilley Rd,Suite 160, Abilene, TX 79602 USA. EM aggiedoc2000@gmail.com OI Camacho, Macario/0000-0001-9200-9085 FU American Academy of Otolaryngology-Head and Neck Surgery FX American Academy of Otolaryngology-Head and Neck Surgery. NR 30 TC 1 Z9 1 U1 0 U2 0 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0194-5998 EI 1097-6817 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD DEC PY 2015 VL 153 IS 6 BP 951 EP 956 DI 10.1177/0194599815607211 PG 6 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA CX5LS UT WOS:000365743700012 PM 26450750 ER PT J AU Cohen, SP Peterlin, BL Fulton, L Neely, ET Kurihara, C Gupta, A Mali, J Fu, DC Jacobs, MB Plunkett, AR Verdun, AJ Stojanovic, MP Hanling, S Constantinescu, O White, RL McLean, BC Pasquina, PF Zhao, ZR AF Cohen, Steven P. Peterlin, B. Lee Fulton, Larry Neely, Edward T. Kurihara, Connie Gupta, Anita Mali, Jimmy Fu, Diana C. Jacobs, Michael B. Plunkett, Anthony R. Verdun, Aubrey J. Stojanovic, Milan P. Hanling, Steven Constantinescu, Octav White, Ronald L. McLean, Brian C. Pasquina, Paul F. Zhao, Zirong TI Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness SO PAIN LA English DT Article DE Headache; Occipital neuralgia; Pulsed radiofrequency; Steroid injection ID DORSAL-ROOT GANGLION; CHRONIC CLUSTER HEADACHE; CERVICAL RADICULAR PAIN; CONTROLLED-TRIAL; MECHANICAL ALLODYNIA; NEUROPATHIC PAIN; RADIO-FREQUENCY; GREATER; MULTICENTER; BLOCKADE AB Occipital neuralgia (ON) is characterized by lancinating pain and tenderness overlying the occipital nerves. Both steroid injections and pulsed radiofrequency (PRF) are used to treat ON, but few clinical trials have evaluated efficacy, and no study has compared treatments. We performed a multicenter, randomized, double-blind, comparative-effectiveness study in 81 participants with ON or migraine with occipital nerve tenderness whose aim was to determine which treatment is superior. Forty-two participants were randomized to receive local anesthetic and saline, and three 120 second cycles of PRF per targeted nerve, and 39 were randomized to receive local anesthetic mixed with deposteroid and 3 rounds of sham PRF. Patients, treating physicians, and evaluators were blinded to interventions. The PRF group experienced a greater reduction in the primary outcome measure, average occipital pain at 6 weeks (mean change from baseline 22.743 +/- 2.487 vs 21.377 +/- 1.970; P < 0.001), than the steroid group, which persisted through the 6-month follow-up. Comparable benefits favoring PRF were obtained for worst occipital pain through 3 months (mean change from baseline21.925 +/- 3.204 vs20.541 +/- 2.644; P = 0.043), and average overall headache pain through 6 weeks (mean change from baseline 22.738 +/- 2.753 vs 21.120 +/- 2.1; P = 0.037). Adverse events were similar between groups, and few significant differences were noted for nonpain outcomes. We conclude that although PRF can provide greater pain relief forONandmigrainewith occipital nerve tenderness than steroid injections, the superior analgesia may not be accompanied by comparable improvement on other outcome measures. C1 [Cohen, Steven P.] Johns Hopkins Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD USA. [Cohen, Steven P.] Johns Hopkins Sch Med, Dept Phys Med & Rehabil, Baltimore, MD USA. [Cohen, Steven P.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Peterlin, B. Lee] Johns Hopkins Sch Med, Dept Neurol, Baltimore, MD USA. [Fulton, Larry] Texas Tech Sch Med, Dept Hlth Org Management, Lubbock, TX USA. [Neely, Edward T.] Walter Reed Natl Mil Med Ctr, Dept Neurol, Bethesda, MD USA. [Kurihara, Connie] Walter Reed Natl Mil Med Ctr, Dept Surg, Bethesda, MD USA. [Kurihara, Connie] Walter Reed Natl Mil Med Ctr, Dept Nursing, Bethesda, MD USA. [Gupta, Anita] Drexel Univ, Dept Anesthesiol, Philadelphia, PA 19104 USA. [Mali, Jimmy; Plunkett, Anthony R.] Womack Army Med Ctr, Ft Bragg, NC USA. [Fu, Diana C.] Naval Med Ctr San Diego, Dept Neurol, San Diego, CA USA. [Jacobs, Michael B.] Walter Reed Natl Mil Med Ctr, Dept Phys Med & Rehabil, Bethesda, MD USA. [Verdun, Aubrey J.] Walter Reed Natl Mil Med Ctr, Dept Anesthesiol, Bethesda, MD USA. [Stojanovic, Milan P.] Boston VA Hosp, Dept Anesthesiol, Boston, MA USA. [Hanling, Steven] Naval Med Ctr San Diego, Dept Anesthesiol, San Diego, CA USA. [Constantinescu, Octav; White, Ronald L.] Landstuhl Reg Med Ctr, Dept Surg, Landstuhl, Germany. [McLean, Brian C.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. [Pasquina, Paul F.] Uniformed Serv Univ Hlth Sci, Dept Phys Med & Rehabil, Bethesda, MD 20814 USA. [Pasquina, Paul F.] DC VA Hosp, Dept Internal Med, Washington, DC USA. [Zhao, Zirong] DC VA Hosp, Dept Neurol, Washington, DC USA. RP Cohen, SP (reprint author), Johns Hopkins Dept Anesthesiol, 550 North Broadway,Suite 301, Baltimore, MD 21205 USA. EM scohen40@jhmi.edu FU Center for Rehabilitation Sciences Research, Bethesda, MD FX Funded by a Congressional Grant from the Center for Rehabilitation Sciences Research, Bethesda, MD; Role of funding source: The role of the funding source was to pay for non-government personnel and to reimburse institutions for the costs of the procedures. NR 59 TC 1 Z9 2 U1 2 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3959 EI 1872-6623 J9 PAIN JI Pain PD DEC PY 2015 VL 156 IS 12 BP 2585 EP 2594 DI 10.1097/j.pain.0000000000000373 PG 10 WC Anesthesiology; Clinical Neurology; Neurosciences SC Anesthesiology; Neurosciences & Neurology GA CX3KS UT WOS:000365598300024 PM 26447705 ER PT J AU Pati, S Pilia, M Grimsley, JM Karanikas, AT Oyeniyi, B Holcomb, JB Cap, AP Rasmussen, TE AF Pati, Shibani Pilia, Marcello Grimsley, Juanita M. Karanikas, Alexia T. Oyeniyi, Blessing Holcomb, John B. Cap, Andrew P. Rasmussen, Todd E. TI CELLULAR THERAPIES IN TRAUMA AND CRITICAL CARE MEDICINE: FORGING NEW FRONTIERS SO SHOCK LA English DT Review DE Acute kidney injury; acute renal failure; burns; cellular therapies; extremity injury; hemorrhagic shock; neurotrauma; organ injury; orthopedic trauma; spinal cord injury; stem cells; trauma and critical care medicine; traumatic brain injury; wound healing ID MESENCHYMAL STEM-CELLS; SPINAL-CORD-INJURY; RESPIRATORY-DISTRESS-SYNDROME; ACUTE KIDNEY INJURY; RANDOMIZED CONTROLLED-TRIAL; MARROW STROMAL CELLS; ACUTE LUNG INJURY; ACUTE-RENAL-FAILURE; EXTREMITY VASCULAR INJURY; BONE-MARROW AB Trauma is a leading cause of death in both military and civilian populations worldwide. Although medical advances have improved the overall morbidity and mortality often associated with trauma, additional research and innovative advancements in therapeutic interventions are needed to optimize patient outcomes. Cell-based therapies present a novel opportunity to improve trauma and critical care at both the acute and chronic phases that often follow injury. Although this field is still in its infancy, animal and human studies suggest that stem cells may hold great promise for the treatment of brain and spinal cord injuries, organ injuries, and extremity injuries such as those caused by orthopedic trauma, burns, and critical limb ischemia. However, barriers in the translation of cell therapies that include regulatory obstacles, challenges in manufacturing and clinical trial design, and a lack of funding are critical areas in need of development. In 2015, the Department of Defense Combat Casualty Care Research Program held a joint military-civilian meeting as part of its effort to inform the research community about this field and allow for effective planning and programmatic decisions regarding research and development. The objective of this article is to provide a state of the science review regarding cellular therapies in trauma and critical care, and to provide a foundation from which the potential of this emerging field can be harnessed to mitigate outcomes in critically ill trauma patients. C1 [Pati, Shibani] Blood Syst Res Inst, San Francisco, CA USA. [Pati, Shibani] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Pilia, Marcello; Grimsley, Juanita M.; Rasmussen, Todd E.] Combat Casualty Care Res Program, Ft Detrick, MD USA. [Karanikas, Alexia T.] Booz Allen Hamilton, Rockville, MD USA. [Oyeniyi, Blessing; Holcomb, John B.] Univ Texas Houston, Dept Surg, Houston, TX USA. [Cap, Andrew P.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Rasmussen, TE (reprint author), US Army, Med Res Mat Command, Combat Casualty Care Res Program, 722 Doughten Dr,Bldg 722, Ft Detrick, MD 21702 USA. EM todd.e.rasmussen.mil@mail.mil NR 149 TC 3 Z9 3 U1 0 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD DEC PY 2015 VL 44 IS 6 BP 505 EP 523 DI 10.1097/SHK.0000000000000482 PG 19 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA CX4LZ UT WOS:000365673700002 PM 26428845 ER PT J AU Janak, JC Howard, JT Goei, KA Weber, R Muniz, GW Hinojosa-Laborde, C Convertino, VA AF Janak, Jud C. Howard, Jeffrey T. Goei, Kathleen A. Weber, Rachael Muniz, Gary W. Hinojosa-Laborde, Carmen Convertino, Victor A. TI PREDICTORS OF THE ONSET OF HEMODYNAMIC DECOMPENSATION DURING PROGRESSIVE CENTRAL HYPOVOLEMIA: COMPARISON OF THE PERIPHERAL PERFUSION INDEX, PULSE PRESSURE VARIABILITY, AND COMPENSATORY RESERVE INDEX SO SHOCK LA English DT Article DE Hemorrhage; hypovolemia; physiologic monitoring; shock ID BODY NEGATIVE-PRESSURE; HEART-RATE-VARIABILITY; TRAUMA PATIENTS; BLOOD-LOSS; COMBAT CASUALTIES; ARTERIAL-PRESSURE; SEPTIC SHOCK; HEMORRHAGE; TOLERANCE; HYPOTENSION AB Introduction:As technological advances allow for the development of more sophisticated measurement of the mechanisms that contribute to compensation for loss of circulating blood volume such as hemorrhage, it is important to compare the discriminative ability of these new measures to standard vital signs and other new physiologic metrics of interest. The purpose of this study was to compare the discriminative ability of the following three measures to predict the onset of hemodynamic decompensation: peripheral perfusion index (PPI), pulse pressure variability (PPV), and the compensatory reserve index (CRI).Materials and Methods:There were 51 healthy participants who underwent a progressive simulated hemorrhage to induce central hypovolemia by lower body negative pressure (LBNP). The least-squares means and 95% confidence intervals for each measure were reported by LBNP level and stratified by tolerance status (high tolerance vs. low tolerance). Generalized estimating equations were used to perform repeated measures logistic regression analysis by regressing the onset of hemodynamic decompensation on each of the vital signs of interest. These probabilities were used to calculate sensitivity, specificity, and receiver-operating characteristic area under the curve (ROCAUC) for PPI, PPV, and CRI.Results:Compared with both PPV (ROCAUC=0.79) and PPI (0.56), the CRI (0.90) had superior discriminative ability (P0.0001) to predict the onset of hemodynamic decompensation. This included higher sensitivity (0.86 vs. 0.78 and 0.71) and specificity (0.78 vs. 0.69 and 0.29) for the CRI compared with PPV and PPI, respectively. Further, CRI was the only measure with mean predicted probabilities of the onset of hemodynamic decompensation that progressively increased as the level of simulated hemorrhage increased.Discussion:There are two potential rationales for why the CRI had superior discriminative ability to predict hemodynamic decompensation. First, the CRI more accurately predicted the onset of hemodynamic decompensation at all levels of simulated hemorrhage, but especially at lower levels of hemorrhage. Second, the CRI was better able to differentiate high versus low tolerant participants.Conclusion:Consistent with previous research, the CRI had superior discriminative ability to predict the onset of hemodynamic decompensation. For those patients at greatest risk for developing impending circulatory shock, identifying the most sensitive and specific measures of the onset of hemodynamic decompensation is critical for both the early recognition and implementation of life-saving interventions. C1 [Janak, Jud C.; Howard, Jeffrey T.; Muniz, Gary W.; Hinojosa-Laborde, Carmen; Convertino, Victor A.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX USA. [Goei, Kathleen A.] Univ Incarnate Word, San Antonio, TX USA. [Weber, Rachael] Univ Texas San Antonio, San Antonio, TX USA. RP Janak, JC (reprint author), 3698 Chambers Pass,Bldg 3611, San Antonio, TX 78234 USA. EM judson.c.janak.vol@mail.mil FU Internship/Research Participation Program at the United States Army Institute of Surgical Research; US Army Combat Casualty Care Research Program [D-009-2014-USAISR] FX Support and funding for this study was provided in part by an appointment to the Internship/Research Participation Program at the United States Army Institute of Surgical Research, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and EPA, and a grant from the US Army Combat Casualty Care Research Program (D-009-2014-USAISR). The authors report no conflicts of interest. NR 38 TC 3 Z9 3 U1 2 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD DEC PY 2015 VL 44 IS 6 BP 548 EP 553 DI 10.1097/SHK.0000000000000480 PG 6 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA CX4LZ UT WOS:000365673700006 PM 26529655 ER PT J AU Prat, NJ Meyer, AD Langer, T Montgomery, RK Parida, BK Batchinsky, AI Cap, AP AF Prat, Nicolas J. Meyer, Andrew D. Langer, Thomas Montgomery, Robbie K. Parida, Bijaya K. Batchinsky, Andriy I. Cap, Andrew P. TI LOW-DOSE HEPARIN ANTICOAGULATION DURING EXTRACORPOREAL LIFE SUPPORT FOR ACUTE RESPIRATORY DISTRESS SYNDROME IN CONSCIOUS SHEEP SO SHOCK LA English DT Article DE Acute respiratory distress syndrome; anticoagulation; blood platelet; extracorporeal life support; extracorporeal membrane oxygenation; trauma ID TRAUMATIC BRAIN-INJURY; ACUTE LUNG INJURY; MEMBRANE-OXYGENATION; GAS-EXCHANGE; UNITED-STATES; PLATELET; FAILURE; VENTILATION; ADULTS; BLOOD AB Background:Over 32% of burned battlefield causalities develop trauma-induced hypoxic respiratory failure, also known as acute respiratory distress syndrome (ARDS). Recently, 9 out of 10 US combat soldiers' survived life-threatening trauma-induced ARDS supported with extracorporeal membrane oxygenation (ECMO), a portable form of cardiopulmonary bypass. Unfortunately, the size, incidence of coagulation complications, and the need for systematic anticoagulation for traditional ECMO devices have prevented widespread use of this lifesaving technology. Therefore, a compact, mobile, ECMO system using minimal anticoagulation may be the solution to reduce ARDS in critically ill military and civilian patients.Methods:We conducted a prospective cohort laboratory investigation to evaluate the coagulation function in an ovine model of oleic acid induced ARDS supported with veno-venous ECMO. The experimental design approximated the time needed to transport from a battlefield setting to an advanced facility and compared bolus versus standard heparin anticoagulation therapy.Results:Comprehensive coagulation and hemostasis assays did not show any difference because of ECMO support over 10h between the two groups but did show changes because of injury. Platelet count and function did decrease with support on ECMO, but there was no significant bleeding or clot formation during the entire experiment.Conclusions:A bolus heparin injection is sufficient to maintain ECMO support for up to 10h in an ovine model of ARDS. With a reduced need for systematic anticoagulation, ECMO use for battlefield trauma could reduce significant morbidity and mortality from ventilator-induced lung injury and ARDS. Future studies will investigate the mechanisms and therapies to support patients for longer periods on ECMO without coagulation complications.Level of Evidence:Vtherapeutic animal experiment. C1 [Prat, Nicolas J.] French Armed Forces Inst Biomed Res IRBA, Paris, France. [Meyer, Andrew D.] Univ Texas Hlth Sci Ctr San Antonio, Div Pediat Crit Care, San Antonio, TX 78229 USA. [Langer, Thomas] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Anesthesia Intens Care Med Emergency & Urgen, Milan, Italy. [Meyer, Andrew D.; Montgomery, Robbie K.; Parida, Bijaya K.; Cap, Andrew P.] US Army Inst Surg Res, Coagulat & Blood Res, Ft Sam Houston, TX USA. [Langer, Thomas; Batchinsky, Andriy I.] US Army Inst Surg Res, Comprehens Intens Care Res, Ft Sam Houston, TX USA. RP Meyer, AD (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Pediat Crit Care, 7703 Floyd Curl Dr MC 7829, San Antonio, TX 78229 USA. EM meyera@uthscsa.edu RI PRAT, Nicolas/R-4213-2016 FU NCATS NIH HHS [KL2 TR001118] NR 44 TC 4 Z9 4 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD DEC PY 2015 VL 44 IS 6 BP 560 EP 568 DI 10.1097/SHK.0000000000000459 PG 9 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA CX4LZ UT WOS:000365673700008 PM 26263439 ER PT J AU Phasomkusolsil, S Pantuwattana, K Tawong, J Khongtak, W Kertmanee, Y Monkanna, N Klein, TA Kim, HC McCardle, PW AF Phasomkusolsil, Siriporn Pantuwattana, Kanchana Tawong, Jaruwan Khongtak, Weeraphan Kertmanee, Yossasin Monkanna, Nantaporn Klein, Terry A. Kim, Heung-Chul McCardle, Patrick W. TI The relationship between wing length, blood meal volume, and fecundity for seven colonies of Anopheles species housed at the Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand SO ACTA TROPICA LA English DT Article DE Anopheles; Blood meal volume; Wing length; Feeding duration; Oviposition ID REPUBLIC-OF-KOREA; AEDES-AEGYPTI; REPRODUCTIVE SUCCESS; DIPTERA-CULICIDAE; CULEX-NIGRIPALPUS; FEEDING SUCCESS; MALARIA VECTORS; SIZE VARIATION; BODY-SIZE; MOSQUITO AB Established colonies of Anopheles campestris, Anopheles cracens, Anopheles dirus, Anopheles kleini, Anopheles minimus, Anopheles sawadwongporni, and Anopheles sinensis are maintained at the Armed Forces Research Institute of Medical Sciences (AFRIMS). Females were provided blood meals on human blood containing citrate as an anticoagulant using an artificial membrane feeder. The mean wing length, used as an estimate of body size, for each species was compared to blood-feeding duration (time), blood meal volume, and numbers of eggs oviposited. Except for An. campestris and An. cracens, there were significant interspecies differences in wing length. The mean blood meal volumes (mm(3)) of An. kleini and An. sinensis were significantly higher than the other 5 species. For all species, the ratios of unfed females weights/blood meal volumes were similar (range: 0.76-0.88), except for An. kleini (1.08) and An. cracens (0.52), that were significantly higher and lower, respectively. Adult females were allowed to feed undisturbed for 1, 3, and 5 mm intervals before blood feeding was interrupted. Except for An. cam pestris and An. sawadwongporni, the number of eggs oviposited were significantly higher for females that fed for 3 min when compared to those that only fed for 1 min. This information is critical to better understand the biology of colonized Anopheles spp. and their role in the transmission of malaria parasites as they relate to the relative size of adult females, mean volumes of blood of engorged females for each of the anopheline species, and the effect of blood feeding duration on specific blood meal volumes and fecundity. (C) 2015 Elsevier B.V. All rights reserved. C1 [Phasomkusolsil, Siriporn; Pantuwattana, Kanchana; Tawong, Jaruwan; Khongtak, Weeraphan; Kertmanee, Yossasin; Monkanna, Nantaporn; McCardle, Patrick W.] US Army Med Component, Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Klein, Terry A.] Publ Hlth Command Reg Pacific, Camp Zama, Japan. [Kim, Heung-Chul] 168th Multifunct Med Battal, Med Detachment 5, APO, AP 96205 USA. RP Phasomkusolsil, S (reprint author), US Army Med Component, Armed Forces Res Inst Med Sci, Dept Entomol, 315-6 Ratchawithi Rd, Bangkok 10400, Thailand. EM siripornp@afrims.org FU U.S. Army Medical and Material Command, Fort Detrick, MD; Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response System (AFHSC-GEIS), Silver Spring, MD; Public Health Command Region-Pacific, Camp Zama, Japan; 65th Medical Brigade, Yongsan US Army Garrison, Seoul, Korea FX Funding for this project was partially provided by the U.S. Army Medical and Material Command, Fort Detrick, MD, the Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response System (AFHSC-GEIS), Silver Spring, MD, the Public Health Command Region-Pacific, Camp Zama, Japan, and the 65th Medical Brigade, Yongsan US Army Garrison, Seoul, Korea. The views expressed in this paper are those of the authors and do not represent the position and/or reflect the official policy of the Department of the Army, the Department of Defense or the U.S. Government. NR 42 TC 1 Z9 1 U1 1 U2 15 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0001-706X EI 1873-6254 J9 ACTA TROP JI Acta Trop. PD DEC PY 2015 VL 152 BP 220 EP 227 DI 10.1016/j.actatropica.2015.09.021 PG 8 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA CW5SW UT WOS:000365057900032 PM 26433074 ER PT J AU Excler, JL Robb, ML Kim, JH AF Excler, Jean-Louis Robb, Merlin L. Kim, Jerome H. TI Prospects for a Globally Effective HIV-1 Vaccine SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; BROADLY NEUTRALIZING ANTIBODIES; RECOMBINANT GLYCOPROTEIN-120 VACCINE; T-CELL VACCINE; CONTROLLED PHASE-3 TRIAL; HIGHLY PATHOGENIC SIV; RHESUS-MONKEYS; EFFICACY TRIAL; IMMUNE-RESPONSES; DOUBLE-BLIND AB A globally effective vaccine strategy must cope with the broad genetic diversity of HIV and contend with multiple transmission modalities. Understanding correlates of protection and the role of diversity in limiting protective vaccines with those correlates is key. RV144 was the first HIV-1 vaccine trial to demonstrate efficacy against HIV-1 infection. A correlates analysis comparing vaccine-induced immune responses in vaccinated-infected and vaccinated-uninfected volunteers suggested that IgG specific for the V1V2 region of gp120 was associated with reduced risk of HIV-1 infection and that plasma Env IgA was directly correlated with infection risk. RV144 and recent non-human primate (NHP) challenge studies suggest that Env is essential and perhaps sufficient to induce protective antibody responses against mucosally acquired HIV-1. Whether RV144 immune correlates can apply to different HIV vaccines, to populations with different modes and intensity of transmission, or to divergent HIV-1 subtypes remains unknown. Newer prime-boost mosaic and conserved sequence immunization strategies aiming at inducing immune responses of greater breadth and depth as well as the development of immunogens inducing broadly neutralizing antibodies should be actively pursued. Efficacy trials are now planned in heterosexual populations in southern Africa and men who have sex with men in Thailand. Although NHP challenge studies may guide vaccine development, human efficacy trials remain key to answer the critical questions leading to the development of a global HIV-1 vaccine for licensure. (C) 2015 by American Journal of Preventive Medicine and Elsevier Ltd. All rights reserved. C1 [Excler, Jean-Louis; Robb, Merlin L.; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil HIV Res Program, Bethesda, MD USA. [Excler, Jean-Louis; Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. RP Excler, JL (reprint author), US Mil HIV Res Program MHRP, 6720-A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA. EM jexcler@hivresearch.org FU Merck; Novartis; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DOD) [W81XWH-07-2-0067] FX This article is being published concurrently in the American Journal of Preventive Medicine and Vaccine. The articles are identical except for stylistic changes in keeping with each journal's style. Either of these versions may be used in citing this article. Publication of this article was supported by Merck and Novartis.; The preparation of this manuscript was supported in part by an Interagency Agreement Y1-AI-2642-12 between U.S. Army Medical Research and Materiel Command (USAMRMC) and the National Institutes of Allergy and Infectious Diseases. In addition, this work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD). NR 154 TC 5 Z9 6 U1 2 U2 15 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 EI 1873-2607 J9 AM J PREV MED JI Am. J. Prev. Med. PD DEC PY 2015 VL 49 IS 6 SU 4 BP S307 EP S318 DI 10.1016/j.amepre.2015.09.004 PG 12 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA CW5UI UT WOS:000365061700002 PM 26590431 ER PT J AU Thomas, SJ Rothman, AL AF Thomas, Stephen J. Rothman, Alan L. TI Trials and Tribulations on the Path to Developing a Dengue Vaccine SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID HUMAN INFECTION MODEL; CLINICAL LABORATORY RESPONSES; NEUTRALIZING ANTIBODY-LEVELS; HEALTHY ADULT VOLUNTEERS; FLAVIVIRUS-NAIVE ADULTS; PRIMARY-SCHOOL CHILDREN; VIRUS-INFECTION; NONHUMAN-PRIMATES; HUMAN CHALLENGE; JAPANESE ENCEPHALITIS AB Dengue is a rapidly expanding global health problem. Development of a safe and efficacious tetravalent vaccine along with strategic application of vector control activities represents a promising approach to reducing the global disease burden. Although many vaccine development challenges exist, numerous candidates are in clinical development and one has been tested in three clinical endpoint studies. The results of these studies have raised numerous questions about how we measure vaccine immunogenicity and how these readouts are associated with clinical outcomes in vaccine recipients who experience natural infection. In this review the authors discuss the dengue vaccine pipeline, development challenges, the dengue vaccine-immunologic profiling intersection, and research gaps. (C) 2015 by American Journal of Preventive Medicine and Elsevier Ltd. All rights reserved. C1 [Thomas, Stephen J.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Rothman, Alan L.] Univ Rhode Isl, Providence, RI 02908 USA. RP Thomas, SJ (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. EM stephen.j.thomas3.mil@mail.mil OI Rothman, Alan/0000-0002-4064-6848 FU Merck; Novartis FX This article is being published concurrently in the American Journal of Preventive Medicine and Vaccine. The articles are identical except for stylistic changes in keeping with each journal's style. Either of these versions may be used in citing this article. Publication of this article was supported by Merck and Novartis. NR 135 TC 5 Z9 5 U1 0 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 EI 1873-2607 J9 AM J PREV MED JI Am. J. Prev. Med. PD DEC PY 2015 VL 49 IS 6 SU 4 BP S334 EP S344 DI 10.1016/j.amepre.2015.09.006 PG 11 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA CW5UI UT WOS:000365061700004 PM 26590433 ER PT J AU Bair, EH Simenhois, R van Hervvijnen, A Birkeland, KW AF Bair, Edward H. Simenhois, Ron van Hervvijnen, Alec Birkeland, Karl W. TI Using 2 m Extended Column Tests to assess slope stability SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article DE Snow; Avalanche; Stability tests; Extended Column Tests ID PROPAGATION; FRACTURE AB Extended Column Tests (ECTs) are used to assess crack initiation and propagation. Previous research shows that tests 90 cm in length may propagate, suggesting instability, while tests 2 m in length may not propagate, suggesting stability, for identical snowpacks. A practical question is: are 90 cm ECTs optimal for assessing stability? To test the added value of 2 m ECTs for stability evaluation, we collected data on 220 ECTs, with 136 side-by-side standard length ECTPs (full propagation indicating instability) followed by 2 m ECTs. We only performed 2 m ECTs after a standard ECT propagated because we assumed 2 m ECTs would not propagate if standard length tests did not. These tests were preceded by an a priori stability assessment. Our results show imbalances for both tests. The ECT had a similar probability of detection (0.88-0.92, POD), i.e. the ability to detect unstable conditions, as in previous studies, but a much lower probability of null events (0.54-0.75, PON), i.e. the ability to detect stable conditions, with variation due to the binary classification of "Fair" stability as stable or unstable. Adding a 2 m test after an ECTP result lowered the POD (0.49-0.58), but substantially raised the PON (0.88-0.98) of the combined tests. The proportion of tests in agreement, i.e. ECTP and 2 m ECTP, increases with decreasing stability. We conclude that an ECTP followed by a 2 m ECTP is a clear red flag, indicating instability. The interpretation of an ECTP followed by a 2 m ECTN/X (no propagation) is not clear. Though this result suggests stability, a high potential for a false stable result means we cannot recommend the 2 m ECT for binary stability assessments. (C) 2015 Elsevier B.V. All rights reserved. C1 [Bair, Edward H.] Univ Calif Santa Barbara, Earth Res Inst, Santa Barbara, CA 93106 USA. [Bair, Edward H.] US Army Corps, Engineers Cold Reg Res & Engn Lab, Hanover, NH USA. [Simenhois, Ron] Coeur, Juneau, AK USA. [van Hervvijnen, Alec] WSL Inst Snow & Avalanche Res SLF, Davos, Switzerland. [Birkeland, Karl W.] US Forest Serv, Natl Avalanche Ctr, Bozeman, MT USA. RP Bair, EH (reprint author), Univ Calif Santa Barbara, 6832 Ellison Hall, Santa Barbara, CA 93106 USA. EM nbair@eri.ucsb.edu RI van Herwijnen, Alec/D-5768-2015 FU US Army Corps of Engineers Cold Regions Research and Engineering fellowship FX We thank two anonymous reviewers for their helpful comments. We thank Brandon Schwartz and Andy Anderson at the Sierra Avalanche Center, Sue Burak at the Eastern Sierra Avalanche Center, and Mike Janes at Alaska Electric Light and Power for their stability tests. The first author was partly supported by a US Army Corps of Engineers Cold Regions Research and Engineering fellowship administered by ORISE/ORAU. NR 20 TC 1 Z9 1 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X EI 1872-7441 J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD DEC PY 2015 VL 120 SI SI BP 191 EP 196 DI 10.1016/j.coldregions.2015.06.021 PG 6 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA CW5RX UT WOS:000365055400020 ER PT J AU Deems, JS Gadomski, PJ Vellone, D Evanczyk, R LeWinter, AL Birkeland, KW Finnegan, DC AF Deems, Jeffrey S. Gadomski, Peter J. Vellone, Dominic Evanczyk, Ryan LeWinter, Adam L. Birkeland, Karl W. Finnegan, David C. TI Mapping starting zone snow depth with a ground-based lidar to assist avalanche control and forecasting SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article DE Spatial variability; Snow depth; Lidar; Avalanche; Avalanche control; Laser scanning ID SPATIAL VARIABILITY; SLOPES AB The distribution of snow depth in avalanche starting zones exerts a strong influence on avalanche potential and character. Extreme depth changes over short distances are common, especially in wind-affected, above-treeline environments. Snow depth also affects the ease of avalanche triggering. Experience shows that avalanche reduction efforts are often more successful when targeting shallow trigger point areas near deeper slabs with explosives or ski cutting. Our paper explores the use of high-resolution (cm scale) snow depth and snow depth change maps from terrestrial laser scanning (TLS) data to quantify loading patterns for use in both pre-control planning and in post-control assessment. We present results from a pilot study in three study areas at the Arapahoe Basin ski area in Colorado, USA. A snow-free reference data set was collected in a summer TLS survey. Mapping multiple times during the snow season allowed us to produce time series maps of snow depth and snow depth change at high resolution to explore depth and slab thickness variations due to wind redistribution. We conducted surveys before and after loading events and control work, allowing the exploration of loading patterns, slab thickness, shot and ski cut locations, bed surfaces, entrainment, and avalanche characteristics. We also evaluate the state of TLS for use in operational avalanche control settings. (C) 2015 Elsevier B.V. All rights reserved. C1 [Deems, Jeffrey S.] Univ Colorado, Natl Snow & Ice Data Ctr, UCB 449, Boulder, CO 80309 USA. [Gadomski, Peter J.; LeWinter, Adam L.; Finnegan, David C.] US Army Corps, Engineers Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Vellone, Dominic; Evanczyk, Ryan] Arapahoe Basin Ski Area, Dillon, CO 80435 USA. [Birkeland, Karl W.] US Forest Serv, USDA, Natl Avalanche Ctr, Bozeman, MT 59771 USA. RP Deems, JS (reprint author), Univ Colorado, Natl Snow & Ice Data Ctr, UCB 449, Boulder, CO 80309 USA. EM deems@nsidc.org RI Deems, Jeffrey/E-6484-2016 OI Deems, Jeffrey/0000-0002-3265-8670 FU CIRES Innovative Research Grant; Theo Meiners Research Grant from the American Avalanche Association FX We would like to acknowledge the Arapahoe Basin ski patrol, mountain operations, and management for enabling the data collection and collaborating towards operational integration. We are also grateful to Riegl Laser Measurement Systems GmbH for their innovation and leadership - their new long-range TLS systems make this project possible. Thanks to our two reviewers, whose comments and suggestions greatly improved this manuscript. This work was partially supported by a CIRES Innovative Research Grant, and by a Theo Meiners Research Grant from the American Avalanche Association - we are indebted to Theo for his energy and inspiration to incorporate new science and tools into operational avalanche decision-making. NR 25 TC 5 Z9 5 U1 2 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X EI 1872-7441 J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD DEC PY 2015 VL 120 SI SI BP 197 EP 204 DI 10.1016/j.coldregions.2015.09.002 PG 8 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA CW5RX UT WOS:000365055400021 ER PT J AU McBride, M Tran, P Pollard, KA Letowski, T McMillan, GP AF McBride, Maranda Tran, Phuong Pollard, Kimberly A. Letowski, Tomasz McMillan, Garnett P. TI Effects of Bone Vibrator Position on Auditory Spatial Perception Tasks SO HUMAN FACTORS LA English DT Article DE auditory perception; azimuth; bone conduction; localization; 3D ID LOCALIZATION PERFORMANCE; CONDUCTED SOUND; HEARING; AUDIO; DISPLAYS; SPEECH; IMPACT; LATERALIZATION; REVERBERATION; MASKING AB Objective: This study assessed listeners' ability to localize spatially differentiated virtual audio signals delivered by bone conduction (BC) vibrators and circumaural air conduction (AC) headphones. Background: Although the skull offers little intracranial sound wave attenuation, previous studies have demonstrated listeners' ability to localize auditory signals delivered by a pair of BC vibrators coupled to the mandibular condyle bones. The current study extended this research to other BC vibrator locations on the skull. Method: Each participant listened to virtual audio signals originating from 16 different horizontal locations using circumaural headphones or BC vibrators placed in front of, above, or behind the listener's ears. The listener's task was to indicate the signal's perceived direction of origin. Results: Localization accuracy with the BC front and BC top positions was comparable to that with the headphones, but responses for the BC back position were less accurate than both the headphones and BC front position. Conclusion: This study supports the conclusion of previous studies that listeners can localize virtual 3D signals equally well using AC and BC transducers. Based on these results, it is apparent that BC devices could be substituted for AC headphones with little to no localization performance degradation. Application: BC headphones can be used when spatial auditory information needs to be delivered without occluding the ears. Although vibrator placement in front of the ears appears optimal from the localization standpoint, the top or back position may be acceptable from an operational standpoint or if the BC system is integrated into headgear. C1 [McBride, Maranda] N Carolina Agr & Tech State Univ, Sch Business & Econ, Greensboro, NC 27411 USA. [Tran, Phuong; Pollard, Kimberly A.; Letowski, Tomasz] US Army Res Lab, Aberdeen, MD USA. [McMillan, Garnett P.] Natl Ctr Rehabil Auditory Res, VA Portland Hlth Care System, Portland, OR USA. RP McBride, M (reprint author), N Carolina Agr & Tech State Univ, Dept Management, 1301 E Market St, Greensboro, NC 27411 USA. EM mcbride@ncat.edu NR 42 TC 0 Z9 3 U1 1 U2 6 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0018-7208 EI 1547-8181 J9 HUM FACTORS JI Hum. Factors PD DEC PY 2015 VL 57 IS 8 BP 1443 EP 1458 DI 10.1177/0018720815596272 PG 16 WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Behavioral Sciences; Engineering; Psychology GA CW5NN UT WOS:000365042600015 PM 26224085 ER PT J AU McWilliams, B Yu, J Pankow, M Yen, CF AF McWilliams, B. Yu, J. Pankow, M. Yen, C. -F. TI Ballistic impact behavior of woven ceramic fabric reinforced metal matrix composites SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Metal matrix composites (MMCs); Impact behavior of composites; Finite element method; Dynamic failure mechanisms ID ALUMINUM-MATRIX; MECHANICAL RESPONSE; STRAIN-RATE; PERFORATION; MODEL; DEFORMATION; STRENGTH AB In this paper, the effect of weave architecture on the ballistic impact response of woven fabric metal matrix composites (MMC) is investigated. The ballistic limits, V-50(BL) of four different composites are experimentally determined and post impact characterization is used to investigate the damage mechanisms active during dynamic loading. Numerical modeling implementing an elastic plastic orthotropic material model with hydrostatic pressure dependent yield surface is used to model the pressure dependent response of the MMC during impact to predict the ballistic limit, and to offer insight into the damage mechanisms occurring during dynamic loading of woven fabric reinforced MMC. The correlation between laterally constrained compression testing and ballistic performance is investigated for use as a screening tool to enable rapid evaluation of the relative ballistic performance of potential fabric MMC weave and composite designs as a potential alternative to full scale ballistic testing. It was found that the fabric architecture has significant effect on ballistic performance and through thickness shear strength of the MMCs. It was found that 3D woven MMC is 13% and 40% lower in terms of ballistic limit and through thickness shear strength respectively, than its 2D counterpart. Furthermore, the numerical results successfully predict the ballistic limit of a 2D fabric reinforced MMC within 6% of the experiment and are used to qualitatively elucidate the experimentally observed damage mechanisms. Published by Elsevier Ltd. C1 [McWilliams, B.; Yu, J.; Yen, C. -F.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD USA. [Pankow, M.] N Carolina State Univ, Dept Mech & Aerosp Engn, Raleigh, NC 27695 USA. RP McWilliams, B (reprint author), US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD USA. EM brandon.a.mcwilliams.civ@mail.mil; jian.h.yu.civ@mail.mil; mrpankow@ncsu.edu; chianfong.yen.civ@mail.mil NR 40 TC 2 Z9 3 U1 3 U2 11 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X EI 1879-3509 J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD DEC PY 2015 VL 86 BP 57 EP 66 DI 10.1016/j.ijimpeng.2015.07.005 PG 10 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA CX0CE UT WOS:000365363700005 ER PT J AU Sherburn, JA Roth, MJ Chen, JS Hillman, M AF Sherburn, Jesse A. Roth, Michael J. Chen, J. S. Hillman, Michael TI Meshfree modeling of concrete slab perforation using a reproducing kernel particle impact and penetration formulation SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Reproducing kernel particle method; Meshfree; Concrete; Penetration; Damage mechanics ID SPHERICAL CAVITY-EXPANSION; CONFORMING NODAL INTEGRATION; CONTACT-IMPACT; NUMERICAL-INTEGRATION; COMPOSITE-MATERIALS; SURFACE-CONTACT; FINITE; MECHANICS; TARGETS; DAMAGE AB A meshfree formulation under the reproducing kernel particle method (RKPM) was introduced for modeling the penetration and perforation of brittle geomaterials such as concrete. RKPM provides a robust framework to effectively model the projectile-target interaction and the material failure and fragmentation behaviors that are critical for this class of problems. A stabilized semi-Lagrangian formulation, in conjunction with a multiscale material damage model for brittle geomaterials and a kernel contact algorithm, were introduced for penetration modeling. In this work, the accuracy of the meshfree impact and penetration formulation was studied using a series of large-caliber projectile concrete slab perforation experiments with impact velocities in the ballistic regime. These experiments were selected due to the challenging natute of concrete perforation, and the results were used to validate the effectiveness of the proposed method to model the penetration processes and the concrete target failure. Simulation results confirm the formulation's accuracy for this type of high-rate ballistic problem and establish a basis for extension to other types of impact problems. The results show the importance of properly formulating the method of domain integration to maintain accuracy in the presence of concrete fragmentation, and also highlight the method's ability to capture the fragmentation response without a need for non-physical treatments commonly used in conventional methods. Published by Elsevier Ltd. C1 [Sherburn, Jesse A.; Roth, Michael J.] US Army Engn Res & Dev Ctr, Vicksburg, MS USA. [Chen, J. S.; Hillman, Michael] Univ Calif San Diego, Dept Struct Engn, San Diego, CA 92103 USA. RP Sherburn, JA (reprint author), 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM jesse.a.sherburn@usace.army.mil FU U.S. Army Engineer Research and Development Center [W912HZ-07-C-0019] FX Permission to publish was granted by the Director, Geotechnical and Structures Laboratory, U.S. Army Engineer Research and Development Center. Simulations were partly performed on the Department of Defense Super Computing Resource high performance computers. Financial support from the U.S. Army Engineer Research and Development Center (Contract No. W912HZ-07-C-0019) to UCLA and its subcontract to UC San Diego is greatly acknowledged. NR 62 TC 1 Z9 1 U1 5 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X EI 1879-3509 J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD DEC PY 2015 VL 86 BP 96 EP 110 DI 10.1016/j.ijimpeng.2015.07.009 PG 15 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA CX0CE UT WOS:000365363700008 ER PT J AU Vargas-Gonzalez, LR Gurganus, JC AF Vargas-Gonzalez, Lionel R. Gurganus, James C. TI Hybridized composite architecture for mitigation of non-penetrating ballistic trauma SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Ultra-high molecular weight polyethylene; Non-penetrating ballistic impact; Impact stress; Composite laminate architecture; Blunt trauma ID MOLECULAR-WEIGHT POLYETHYLENE; DYNEEMA(R) COMPOSITES; FIBER COMPOSITES; MATERIAL MODEL; IMPACT; PERFORMANCE; SIMULATIONS AB Ultra-high molecular weight polyethylene (UHWMPE) fiber-based composites are employed in a variety of Soldier protection systems due to their impressive specific strength and elastic wave speed. However, as UHMWPE composites rely on their tenacity to decelerate the projectile impact, even in successfully arrested impacts issues arise with the blunt deformation trauma generated due to high deformation of the material into the Soldier. In this experiment, UHMWPE composite laminates employing two widely different laminate architectures, [0 degrees/90 degrees] and ARL X Hybrid, were evaluated to assess the effect of panel architecture on impact pressures generated in non-penetrating ballistic impact events. Panels were impacted with 7.62 mm lead core projectiles on a testing platform designed for the physics-based evaluation of BHBT of helmet materials. Composite panel deformation for the [0 degrees/90 degrees] configuration impacted the testing frame at velocities 2.2x higher than the ARL X Hybrid specimens, leading to a 526% higher average maximum pressure amplitude measured on the BHBT platform (45.5 +/- 19.1 MPa and 7.3 +/- 3.3 MPa for [0 degrees/90 degrees] and ARL X Hybrid, respectively), demonstrating the effectiveness of ARL X Hybrid in mitigating non-penetrating ballistic impact stress. The experiment has provided critical insight into non-penetrating small arms impact stresses and the role materials, materials processing, and materials design influence non-penetrating blunt trauma response. Published by Elsevier Ltd. C1 [Vargas-Gonzalez, Lionel R.; Gurganus, James C.] US Army, Res Lab, Mat Mfg & Sci Div, ATTN RDRL WMM D, Aberdeen Proving Ground, MD 21005 USA. RP Vargas-Gonzalez, LR (reprint author), US Army, Res Lab, Mat Mfg & Sci Div, ATTN RDRL WMM D, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. EM lionel.r.vargas.civ@mail.mil OI Vargas-Gonzalez, Lionel/0000-0001-6500-1686 NR 40 TC 1 Z9 1 U1 5 U2 14 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X EI 1879-3509 J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD DEC PY 2015 VL 86 BP 295 EP 306 DI 10.1016/j.ijimpeng.2015.08.014 PG 12 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA CX0CE UT WOS:000365363700024 ER PT J AU Mao, HJ Unnikrishnan, G Rakesh, V Reifman, J AF Mao, Haojie Unnikrishnan, Ginu Rakesh, Vineet Reifman, Jaques TI Untangling the Effect of Head Acceleration on Brain Responses to Blast Waves SO JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME LA English DT Article DE blast-induced traumatic brain injury; head acceleration; brain pressure; finite-element model ID INJURY MODEL; SHOCK-WAVE; RAT; CAVITATION; MECHANISM; IMPACT; SKULL AB Multiple injury-causing mechanisms, such as wave propagation, skull flexure, cavitation, and head acceleration, have been proposed to explain blast-induced traumatic brain injury (bTBI). An accurate, quantitative description of the individual contribution of each of these mechanisms may be necessary to develop preventive strategies against bTBI. However, to date, despite numerous experimental and computational studies of bTBI, this question remains elusive. In this study, using a two-dimensional (2D) rat head model, we quantified the contribution of head acceleration to the biomechanical response of brain tissues when exposed to blast waves in a shock tube. We compared brain pressure at the coup, middle, and contre-coup regions between a 2D rat head model capable of simulating all mechanisms (i.e., the all-effects model) and an acceleration-only model. From our simulations, we determined that head acceleration contributed 36-45% of the maximum brain pressure at the coup region, had a negligible effect on the pressure at the middle region, and was responsible for the low pressure at the contre-coup region. Our findings also demonstrate that the current practice of measuring rat brain pressures close to the center of the brain would record only two-thirds of the maximum pressure observed at the coup region. Therefore, to accurately capture the effects of acceleration in experiments, we recommend placing a pressure sensor near the coup region, especially when investigating the acceleration mechanism using different experimental setups. C1 [Mao, Haojie; Unnikrishnan, Ginu; Rakesh, Vineet; Reifman, Jaques] US Army Med Res & Mat Command, US Dept Def, Software Applicat Inst, Telemed & Adv Technol Res Ctr,Biotechnol High Per, Ft Detrick, MD 21702 USA. RP Reifman, J (reprint author), US Army Med Res & Mat Command, US Dept Def, Software Applicat Inst, Telemed & Adv Technol Res Ctr,Biotechnol High Per, 504 Scott St, Ft Detrick, MD 21702 USA. EM jaques.reifman.civ@mail.mil FU U.S. Army Network Science Initiative; U.S. Department of Defense High Performance Computing Modernization Program; Defense Health Agency; NIH Grant [S10 RR23017]; U.S. Army Medical Research and Materiel Command, Fort Detrick, MD FX This research was supported by the U.S. Army Network Science Initiative, U.S. Army Medical Research and Materiel Command, Fort Detrick, MD, the U.S. Department of Defense High Performance Computing Modernization Program, and the Defense Health Agency. The rat head MRI images were acquired at the University of Utah Small Animal Imaging Facility on an instrument funded by NIH Grant No. S10 RR23017. The opinions and assertions contained herein are the private views of the authors and do not reflect the views of the U.S. Army or of the U.S. Department of Defense. NR 39 TC 0 Z9 0 U1 2 U2 6 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0148-0731 EI 1528-8951 J9 J BIOMECH ENG-T ASME JI J. Biomech. Eng.-Trans. ASME PD DEC PY 2015 VL 137 IS 12 AR 124502 DI 10.1115/1.4031765 PG 7 WC Biophysics; Engineering, Biomedical SC Biophysics; Engineering GA CW8SR UT WOS:000365270000012 PM 26458125 ER PT J AU Gandhi, V Bryant, DB Socolofsky, SA Stoesser, T Kim, JH AF Gandhi, Varun Bryant, Duncan B. Socolofsky, Scott A. Stoesser, Thorsten Kim, Jae-Hong TI Concentration-Based Decomposition of the Flow around a Confined Cylinder in a UV Disinfection Reactor SO JOURNAL OF ENGINEERING MECHANICS LA English DT Article ID PROPER ORTHOGONAL DECOMPOSITION; LASER-INDUCED FLUORESCENCE; TURBULENT CHANNEL FLOW; COHERENT STRUCTURES; CIRCULAR-CYLINDER; PIV DATA; WAKE; VISUALIZATION; DYNAMICS; POD AB The proper orthogonal decomposition (POD) is applied to spatial concentration data, obtained using laser-induced fluorescence (LIF), for the flow around a confined circular cylinder (R = 4; 900) and compared with their corresponding velocity and vorticity fields. The velocity, vorticity, and concentration modes identify the dominating coherent structures, i.e., shear layer rollup, instantaneous recirculation and von Karman vortex shedding. In the velocity and vorticity decomposition, instantaneous recirculation, and von Karman vortex shedding are represented in the highest energy modes. However, in the concentration decomposition, the most energetic modes represent the regions with strong concentration intermittency, i.e., where no dye is present, whereas the coherent structures, which are identified in the highest modes in the velocity and vorticity decomposition, are only found in the less energetic modes. The concentration-based decomposition identifies the shear layer around the cylinder, which is only partially captured by its vorticity-based counterpart. (c) 2015 American Society of Civil Engineers. C1 [Gandhi, Varun] Georgia Inst Technol, Sch Civil & Environm Engn, Atlanta, GA 30332 USA. [Bryant, Duncan B.] US Army, Engn Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. [Socolofsky, Scott A.] Texas A&M Univ, Zachry Dept Civil Engn, Coastal & Ocean Engn Div, College Stn, TX 77843 USA. [Stoesser, Thorsten] Cardiff Univ, Sch Engn, Cardiff CF24 3AA, S Glam, Wales. [Kim, Jae-Hong] Yale Univ, Sch Engn & Appl Sci, New Haven, CT 06511 USA. RP Stoesser, T (reprint author), Cardiff Univ, Sch Engn, Cardiff CF24 3AA, S Glam, Wales. EM stoesser@cf.ac.uk FU Water Research Foundation [4134]; Korea Water Resources Corporation (Kwater) FX This research was partially funded by Water Research Foundation (Project No. 4134) and Korea Water Resources Corporation (Kwater). NR 40 TC 0 Z9 0 U1 4 U2 4 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9399 EI 1943-7889 J9 J ENG MECH JI J. Eng. Mech. PD DEC PY 2015 VL 141 IS 12 AR UNSP 04015050 DI 10.1061/(ASCE)EM.1943-7889.0000959 PG 12 WC Engineering, Mechanical SC Engineering GA CW6RD UT WOS:000365124300005 ER PT J AU Pak, JH Fleming, M Scharffenberg, W Gibson, S Brauer, T AF Pak, Jang Hyuk Fleming, Matthew Scharffenberg, William Gibson, Stanford Brauer, Thomas TI Modeling Surface Soil Erosion and Sediment Transport Processes in the Upper North Bosque River Watershed, Texas SO JOURNAL OF HYDROLOGIC ENGINEERING LA English DT Article DE Hydrologic Engineering Center-Hydrologic Modeling System (HEC-HMS); Surface soil erosion; Reservoir siltation; Sediment transport ID UNCERTAINTY; BASINS AB A sediment transport module added to the Hydrologic Engineering Center's Hydrologic Modeling System (HEC-HMS) Version 4.0 computes surface erosion, reach routing, and reservoir trap efficiency. The HEC-HMS sediment transport module was applied to the Upper North Bosque River Watershed (UNBRW) in central Texas, a well-instrumented watershed with good parameterization and calibration data, to test model robustness. The UNBRW is 98% rural including rangeland, forage, and dairy waste application fields. Simulation results were compared to observed average daily total suspended solid (TSS) data at five gauge locations. The HEC-HMS results matched observed TSS across the UNBRW (<1% error at all gauges) during model calibration and maintained modest residuals (-31 to 12% error) during the validation period. The HEC-HMS also performed well compared to published results through two other commonly used models. (C) 2015 American Society of Civil Engineers. C1 [Pak, Jang Hyuk; Scharffenberg, William; Gibson, Stanford] US Army Corps Engineers, Inst Water Resources, Hydrol Engn Ctr, Davis, CA 95616 USA. [Fleming, Matthew] US Army Corps Engineers, Inst Water Resources, Hydrol Engn Ctr, Hydrol & Hydraul Technol Div, Davis, CA 95616 USA. [Brauer, Thomas] US Army Corps Engineers, Galveston, TX 77550 USA. RP Pak, JH (reprint author), US Army Corps Engineers, Inst Water Resources, Hydrol Engn Ctr, 609 Second St, Davis, CA 95616 USA. EM jay.h.pak@usace.army.mil FU System Wide Water Resources Program (SWWRP); Flood and Coastal Storm Damage Reduction Research and Development (RD) program of the U.S. Army Corps of Engineers FX Ann McFarland of the Texas Institute for Applied Environmental Research, Tarleton State University, is thanked for data support. The development of STM in HEC-HMS 4.0 was funded by the System Wide Water Resources Program (SWWRP) and Flood and Coastal Storm Damage Reduction Research and Development (RD) program of the U.S. Army Corps of Engineers. NR 48 TC 0 Z9 0 U1 7 U2 16 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1084-0699 EI 1943-5584 J9 J HYDROL ENG JI J. Hydrol. Eng. PD DEC PY 2015 VL 20 IS 12 AR UNSP 04015034 DI 10.1061/(ASCE)HE.1943-5584.0001205 PG 13 WC Engineering, Civil; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA CW6TD UT WOS:000365129800005 ER PT J AU Harbertson, J Scott, PT Moore, J Wolf, M Morris, J Thrasher, S D'Onofrio, M Grillo, MP Jacobs, MB Tran, BR Tian, J Ito, SI McAnany, J Michael, N Hale, BR AF Harbertson, Judith Scott, Paul T. Moore, John Wolf, Michael Morris, James Thrasher, Scott D'Onofrio, Michael Grillo, Michael P. Jacobs, Marni B. Tran, Bonnie R. Tian, Jun Ito, Stanley I. McAnany, Jennifer Michael, Nelson Hale, Braden R. TI Sexually transmitted infections and sexual behaviour of deploying shipboard US military personnel: a cross-sectional analysis SO SEXUALLY TRANSMITTED INFECTIONS LA English DT Article ID UNITED-STATES; CHLAMYDIAL INFECTION; DISEASES; RISK; TRANSMISSION; GONORRHEA; HIV; MEN; DETERMINANTS; PARTNERSHIPS AB Objectives Sexually transmitted infection (STI) prevalence and risk behaviour may differ at different phases of deployment. We examined STI prevalence and sexual behaviour in the predeployment time period (12 months prior) among recently deployed shipboard US Navy and Marine Corps military personnel. Methods Data were collected from 1938 male and 515 female service members through an anonymous, self-completed survey assessing sexual behaviours and STI acquisition characteristics in the past 12 months. Cross-sectional sex-stratified descriptive statistics are reported. Results Overall, 67% (n=1262/1896) reported last sex with a military beneficiary (spouse, n=931, non-spouse service member, n=331). Among those with a sexual partner outside their primary partnership, 24% (n=90/373) reported using a condom the last time they had sex and 30% (n=72/243) reported their outside partner was a service member. In total, 90% (n=210/233) reported acquiring their most recent STI in the USA (88%, n=126/143 among those reporting >= 1 deployments and an STI >= 1 year ago) and a significantly higher proportion (p<0.01) of women than men acquired the STI from their regular partner (54% vs 21%) and/or a service member (50% vs 26%). Conclusions Findings suggest a complex sexual network among service members and military beneficiaries. Findings may extend to other mobile civilian and military populations. Data suggest most STI transmission within the shipboard community may occur in local versus foreign ports but analyses from later time points in deployment are needed. These data may inform more effective STI prevention interventions. C1 [Harbertson, Judith; Scott, Paul T.; D'Onofrio, Michael; Tian, Jun; Michael, Nelson] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Harbertson, Judith; Tian, Jun] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Harbertson, Judith; Grillo, Michael P.; Jacobs, Marni B.; Tran, Bonnie R.; Ito, Stanley I.; McAnany, Jennifer; Hale, Braden R.] US Dept Def, HIV AIDS Prevent Program DHAPP, Naval Hlth Res Ctr, San Diego, CA USA. [Moore, John; Wolf, Michael; Morris, James; Thrasher, Scott] US Navy, San Diego, CA 92152 USA. [Hale, Braden R.] Univ Calif San Diego, Sch Med, Dept Med, Div Infect Dis, San Diego, CA 92103 USA. RP Harbertson, J (reprint author), Naval Hlth Res Ctr, US Mil HIV Res Program, 140 Sylvester Rd, San Diego, CA 92106 USA. EM judith.harbertson.ctr@mail.mil NR 28 TC 3 Z9 3 U1 2 U2 2 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1368-4973 EI 1472-3263 J9 SEX TRANSM INFECT JI Sex. Transm. Infect. PD DEC PY 2015 VL 91 IS 8 BP 581 EP 588 DI 10.1136/sextrans-2015-052163 PG 8 WC Infectious Diseases SC Infectious Diseases GA CW9UX UT WOS:000365344800012 PM 26586849 ER PT J AU Wasonga, C Inoue, S Rumberia, C Michuki, G Kimotho, J Ongus, JR Sang, R Musila, L AF Wasonga, Caroline Inoue, Shingo Rumberia, Cecilia Michuki, George Kimotho, James Ongus, Juliette R. Sang, Rosemary Musila, Lillian TI Genetic divergence of Chikungunya virus plaque variants from the Comoros Island (2005) SO VIRUS GENES LA English DT Article DE Chikungunya virus; Variants; Genetic variation; Comoros Island ID INDIAN-OCEAN OUTBREAK; ONYONG-NYONG VIRUSES; SRI-LANKA; INFECTION; SEROPREVALENCE; REEMERGENCE; SEQUENCE; MOSQUITO; GENOME AB Chikungunya virus (CHIKV) from a human sample collected during the 2005 Chikungunya outbreak in the Comoros Island, showed distinct and reproducible large (L2) and small (S7) plaques which were characterized in this study. The parent strain and plaque variants were analysed by in vitro growth kinetics in different cell lines and their genetic similarity assessed by whole genome sequencing, comparative sequence alignment and phylogenetic analysis. In vitro growth kinetic assays showed similar growth patterns of both plaque variants in Vero cells but higher viral titres of S7 compared to L2 in C6/36 cells. Amino acids (AA) alignments of the CHIKV plaque variants and S27 African prototype strain, showed 30 AA changes in the non-structural proteins (nsP) and 22 AA changes in the structural proteins. Between L2 and S7, only two AAs differences were observed. A missense substitution (C642Y) of L2 in the nsP2, involving a conservative AA substitution and a nonsense substitution (R524X) of S7 in the nsP3, which has been shown to enhance O'nyong-nyong virus infectivity and dissemination in Anopheles mosquitoes. The phenotypic difference observed in plaque size could be attributed to one of these AA substitutions. Phylogenetic analysis showed that the parent strain and its variants clustered closely together with each other and with Indian Ocean CHIKV strains indicating circulation of isolates with close evolutionary relatedness in the same outbreak. These observations pave way for important functional studies to understand the significance of the identified genetic changes in virulence and viral transmission in mosquito and mammalian hosts. C1 [Wasonga, Caroline] Univ Nairobi, Dept Biochem, Nairobi, Kenya. [Wasonga, Caroline; Sang, Rosemary] Kenya Med Res Inst KEMRI, Arbovirus Viral Haemorrhag Fever Lab, Nairobi, Kenya. [Kimotho, James] Kenya Med Res Inst KEMRI, Prod Dept, Nairobi, Kenya. [Inoue, Shingo] Nagasaki Univ, Inst Trop Med, Dept Virol, Nagasaki 8528523, Japan. [Rumberia, Cecilia; Michuki, George] Int Livestock Res Inst, Dept Biol Sci, Nairobi, Kenya. [Ongus, Juliette R.] Jomo Kenyatta Univ Agr & Technol, Med Lab Sci Dept, Nairobi, Kenya. [Ongus, Juliette R.] Int Ctr Insect Physiol & Ecol, Mol Biol & Bioinformat Unit, Nairobi, Kenya. [Musila, Lillian] United States Army, Dept Emerging Infect Dis, Med Res Unit Kenya, Nairobi, Kenya. RP Wasonga, C (reprint author), Univ Nairobi, Dept Biochem, POB 30197-00100, Nairobi, Kenya. EM cwasonga@gmail.com FU Consortium for National Health Research (CNHR), Kenya [RLG09-001/031]; Government of the Comoros Island FX The project was funded by the Consortium for National Health Research (CNHR), Kenya (Project Number RLG09-001/031). This study was also supported with reagents and equipment by JICA-JSPS Project and JICA-JST-SATREPS Project. We acknowledge the Biosciences Eastern and Central Africa - International Livestock Research Institute's (BecA-ILRI-Hub) genomics platform for supporting the sequencing work. We also appreciate the support given by the Government of the Comoros Island. This work was submitted with the permission of the Director, KEMRI, Nairobi, Kenya. NR 20 TC 0 Z9 0 U1 1 U2 5 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0920-8569 EI 1572-994X J9 VIRUS GENES JI Virus Genes PD DEC PY 2015 VL 51 IS 3 BP 323 EP 328 DI 10.1007/s11262-015-1243-4 PG 6 WC Genetics & Heredity; Virology SC Genetics & Heredity; Virology GA CW9PM UT WOS:000365330700001 PM 26347221 ER PT J AU Kirby, SD Norris, J Sweeney, R Bahnson, BJ Cerasoli, DM AF Kirby, Stephen D. Norris, Joseph Sweeney, Richard Bahnson, Brian J. Cerasoli, Douglas M. TI A rationally designed mutant of plasma platelet-activating factor acetylhydrolase hydrolyzes the organophosphorus nerve agent soman SO BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS LA English DT Article DE Nerve agents; Organophosphorus compounds; Plasma platelet-activating factor acetylhydrolase; Bioscavenger; Soman ID ANHYDRIDE HYDROLASE ACTIVITY; HUMAN BUTYRYLCHOLINESTERASE; CRYSTAL-STRUCTURES; COMPLEXES; PHOSPHOLIPASE-A2; TOXICITY; SARIN AB Organophosphorus compounds (Ups) such as satin and soman are some of the most toxic chemicals synthesized by man. They exert toxic effects by inactivating acetylcholinesterase (AChE) and bind secondary target protein. Organophosphorus compounds are hemi-substrates for enzymes of the serine hydrolase superfamily. Enzymes can be engineered by amino acid substitution into OP-hydrolyzing variants (bioscavengers) and used as therapeutics. Some enzymes associated with lipoproteins, such as human plasma platelet-activating factor acetylhydrolase (pPAF-AH), are also inhibited by OPs; these proteins have largely been ignored for engineering purposes because of complex interfacial kinetics and a lack of structural data. We have expressed active human pPAF-AH in bacteria and previously solved the crystal structure of this enzyme with OP adducts. Using these structures as a guide, we created histidine mutations near the active site of pPAF-AH (F322H, W298H, L153H) in an attempt to generate novel OP-hydrolase activity. Wild-type pPAF-AH, L153H, and F322H have essentially no hydrolytic activity against the nerve agents tested. In contrast, the W298H mutant displayed novel somanase activity with a k(cat) of 5 min(-1) and a K-M of 590 mu M at pH 7.5. There was no selective preference for hydrolysis of any of the four soman stereoisomers. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license. C1 [Kirby, Stephen D.; Norris, Joseph; Sweeney, Richard; Cerasoli, Douglas M.] US Army, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. [Kirby, Stephen D.; Bahnson, Brian J.] Univ Delaware, Dept Chem & Biochem, Newark, DE 19716 USA. RP Kirby, SD (reprint author), US Army, Med Res Inst Chem Def, Div Res, Physiol & Immunol Branch, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM stephen.d.kirby.civ@mail.mil FU Defense Threat Reduction Agency Joint Science and Technology Office, Medical ST Division; NIH from the National Institute of General Medical Sciences [8P30GM103519]; National Heart, Lung, and Blood Institute [5R01HL084366] FX This research was supported by the Defense Threat Reduction Agency Joint Science and Technology Office, Medical S&T Division. Funding was also obtained from NIH grants 8P30GM103519 from the National Institute of General Medical Sciences, and 5R01HL084366 from the National Heart, Lung, and Blood Institute to B.J.B. The views expressed in this manuscript are those of the authors and do not reflect the official policy of the Department of Army, Department of Defense, or the US. Government. NR 21 TC 2 Z9 2 U1 2 U2 10 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1570-9639 EI 0006-3002 J9 BBA-PROTEINS PROTEOM JI BBA-Proteins Proteomics PD DEC PY 2015 VL 1854 IS 12 BP 1809 EP 1815 DI 10.1016/j.bbapap.2015.09.001 PG 7 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA CW3KJ UT WOS:000364890900001 PM 26343853 ER PT J AU Getter, DJ Davidson, MT Consolazio, GR Patev, RC AF Getter, Daniel J. Davidson, Michael T. Consolazio, Gary R. Patev, Robert C. TI Determination of hurricane-induced barge impact loads on floodwalls using dynamic finite element analysis SO ENGINEERING STRUCTURES LA English DT Article DE Barge; Hurricane; Flood wall; Finite element impact simulation; Impact loads AB During hurricane events, moored barges are at risk of being propelled by high winds and impacting flood protection walls in the vicinity. Cities like New Orleans, Louisiana are at particular risk for such hazards, due to the preponderance of canals and moored barges throughout the city combined with high hurricane risk. Unfortunately, limited information is available to estimate the magnitude of barge impact loads for the design of floodwalls. In this paper, forces associated with hurricane-wind-propelled barge impacts on floodwalls are quantified using high-resolution dynamic finite element simulations. Such simulations account for highly nonlinear material deformation in the impacting barge, nonlinear soil response, and dynamic interaction between the barge, wall, and soil. The paper presents force histories for a variety of representative impact scenarios which can be used directly in dynamic analysis of floodwalls. Additional guidance is provided for employing the force results in static design scenarios. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Getter, Daniel J.; Davidson, Michael T.; Consolazio, Gary R.] Univ Florida, Dept Civil & Coastal Engn, Engn Sch Sustainable Infrastruct & Environm, Gainesville, FL 32611 USA. [Patev, Robert C.] US Army, Risk Management Ctr, Corps Engineers, Concord, MA 01742 USA. RP Consolazio, GR (reprint author), Univ Florida, Dept Civil & Coastal Engn, Engn Sch Sustainable Infrastruct & Environm, PO 116580, Gainesville, FL 32611 USA. EM grc@ufl.edu FU National Science Foundation Graduate Research Fellowship; [674-01-0198-13]; [W912P8-07-D-0054] FX This work was supported under subcontract to Digital Engineering and Imaging Inc., Contract No. 674-01-0198-13, which was under prime contract to the U.S. Army Corps of Engineers, Contract No. W912P8-07-D-0054. Portions of this work were also supported by a National Science Foundation Graduate Research Fellowship. The authors would like to extend thanks to Dr. Patrick Hudson (Moment Engineering) and Dr. Michael McCormick (U.S. Naval Academy) for their contributions to the overall effort of which this work is only part. The authors also thank Mr. Zachary Harper, Mr. Falak Shah, and Mr. Robert Hendrix for their contributions to modeling, simulation, and data processing. NR 22 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0141-0296 EI 1873-7323 J9 ENG STRUCT JI Eng. Struct. PD DEC 1 PY 2015 VL 104 BP 95 EP 106 DI 10.1016/j.engstruct.2015.09.021 PG 12 WC Engineering, Civil SC Engineering GA CW3LV UT WOS:000364894700007 ER PT J AU Reale, JK Van Horn, DJ Condon, KE Dahm, CN AF Reale, Justin K. Van Horn, David J. Condon, Katherine E. Dahm, Clifford N. TI The effects of catastrophic wildfire on water quality along a river continuum SO FRESHWATER SCIENCE LA English DT Article DE water quality; forest fire; continuous monitoring; river continuum; disturbance; dissolved oxygen; turbidity; specific conductance ID WESTERN NORTH-AMERICA; INTERANNUAL VARIATION; ECOSYSTEM METABOLISM; FOREST CATCHMENTS; STREAM ECOSYSTEMS; BOREAL FOREST; NEW-MEXICO; FIRE; SEDIMENT; NUTRIENT AB To further our understanding of the linkages among wildfire, streamflow pathways, and water chemistry, we used a network of water-quality sensors and streamflow gages to assess initial and long-term effects of wildfire along a river continuum. We assessed water quality of a 2nd- and a 4th-order stream in a single watershed for 5 monsoon seasons before, during, and after a catastrophic wildfire. Fire had significant and sustained long-term effects on both streams. In the 2nd-order stream, variability in dissolved O-2 (DO) increased after the fire. Daily total precipitation was unchanged, but episodic storm events resulted in significant increases in stream discharge that led to elevated turbidity and specific conductance (SC). In the 4th-order stream, fire led to minimal measurable effects on turbidity, elevated SC, and greater variability of the DO signal. We also assessed water-quality data from 4 sites along the river continuum for a 4-mo period before, during, and after the wildfire. Large overland and debris-flow events in the 1st- and 2nd-order streams resulted in elevated particles (e.g., soil, sediment, rock, ash, plant biomass) and solutes in transport that elevated turbidity and SC and damped the DO signal. We documented less severe postfire effects in the 3rd-order stream probably because of groundwater contributions and a higher stream gradient with a pool-riffle geomorphology. We observed nominal changes in turbidity, strong SC spikes, and strong DO decreases in the 4th-order stream. Streamflow pathways, geomorphology, physiochemical properties, and biogeochemical processes play a central role in the postfire water-quality response along the river continuum. Our findings highlight the importance of collecting water-quality measurements at temporal and spatial scales that effectively capture hydrological dynamics. C1 [Reale, Justin K.; Van Horn, David J.; Dahm, Clifford N.] Univ New Mexico, Dept Biol, Albuquerque, NM 87131 USA. [Reale, Justin K.] US Army Corps Engineers, Albuquerque, NM 87109 USA. [Condon, Katherine E.] Valles Caldera Natl Preserve, Jemez Springs, NM 87025 USA. RP Reale, JK (reprint author), Univ New Mexico, Dept Biol, Albuquerque, NM 87131 USA. EM justin.k.reale@usace.army.mil; vanhorn@unm.edu; kcondon@vallescaldera.gov; cdahm@sevilleta.unm.edu FU USACE, Albuquerque District; National Science Foundation [EAR-0724958, EAR-1331408]; New Mexico Experimental Program [0814449]; Sevilleta Long-Term Ecological Research (LTER) Program [DEB 0620482] FX We acknowledge Susan Bittick, Cecilia Horner, Amy Louise, and Chelsea Reale from the US Army Corps of Engineers (USACE), Albuquerque District for their support and assistance. David Soballe (USACE, Engineer Research and Development Center), Lee Brown (Guest Editor), and 2 anonymous referees greatly improved the manuscript. Robert Parmenter and Scott Compton of the VCNP provided logistical support and long-term data. We also thank current and former members of the Hydrogeoecology group at the University of New Mexico. The USACE, Albuquerque District, provided support for this program and salary for JKR. The USGS NM Water Science Center and cooperators provided discharge and water quality data. The National Science Foundation provided support for this project to the Catalina-Jemez Critical Zone Observatory (grant EAR-0724958 and EAR-1331408), the New Mexico Experimental Program to Stimulate Competitive Research RII Track I Project (award 0814449), and the Sevilleta Long-Term Ecological Research (LTER) Program (award DEB 0620482). This is publication SEV716 from the Sevilleta LTER Project. Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the US Government. The findings and conclusions in this article are those of the authors and do not necessarily represent the views of the US Government. NR 84 TC 4 Z9 4 U1 15 U2 40 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 2161-9549 EI 2161-9565 J9 FRESHW SCI JI Freshw. Sci. PD DEC PY 2015 VL 34 IS 4 BP 1426 EP 1442 DI 10.1086/684001 PG 17 WC Ecology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA CW2IM UT WOS:000364815000019 ER PT J AU Piccirillo, AL Packnett, ER Boivin, MR Cowan, DN AF Piccirillo, Amanda L. Packnett, Elizabeth R. Boivin, Michael R. Cowan, David N. TI Epidemiology of psychiatric disability without posttraumatic stress disorder among US Army and Marine Corps personnel evaluated for disability discharge SO JOURNAL OF PSYCHIATRIC RESEARCH LA English DT Article DE Military psychiatry; Epidemiology; Disability ID TRAUMATIC BRAIN-INJURY; MENTAL-HEALTH PROBLEMS; MILITARY PERSONNEL; IRAQ; AFGHANISTAN; DEPLOYMENT; VETERANS; SOLDIERS; SERVICE; COMBAT AB Psychiatric disorders are a common reason for disability discharge from the U.S. military. Research on psychiatric disorders in military personnel evaluated for disability discharge has historically focused on posttraumatic stress disorder (PTSD), yet 40% of service members evaluated for a psychiatric-related disability do not have PTSD. This study's objective was to describe characteristics and correlates of disability in Army and Marine Corps personnel diagnosed with psychiatric disorders other than PTSD. In this cross-sectional study, the chi-square and Wilcoxon Mann Whitney tests compared the distribution of demographic, disability and deployment characteristics between those evaluated for non-PTSD psychiatric disability (N = 9125) versus those evaluated for any other non-psychiatric condition (N = 78,072). Multivariate logistic regression examined associations between disability retirement and demographic and disability characteristics. Results show a significantly higher prevalence of disability retirement, deployment, and comorbidity among Army and Marine Corps personnel evaluated for disability discharge related to a non-PTSD psychiatric disorder. Mood disorders, anxiety disorders and dementia were the most commonly evaluated psychiatric disorders. Characteristics associated with increased odds of non-PTSD psychiatric-related disability retirement includes being in the Marine Corps (OR = 1.24), being black (OR = 1.29) or other race (OR = 133), having a combat-related condition (OR = 2.50), and older age. Service members evaluated for a non-PTSD psychiatric disability have similar rates of disability retirement as those evaluated for PTSD, suggesting non-PTSD psychiatric disorders cause a severe and highly compensated disability. Additional research is needed describing the epidemiology of specific non-PTSD psychiatric disorders, such as depression, in service members evaluated for disability discharge. (c) 2015 Elsevier Ltd. All rights reserved. C1 [Piccirillo, Amanda L.; Packnett, Elizabeth R.; Boivin, Michael R.; Cowan, David N.] Walter Reed Army Inst Res, Dept Epidemiol, Prevent Med Branch, Silver Spring, MD 20910 USA. [Piccirillo, Amanda L.; Packnett, Elizabeth R.; Cowan, David N.] ManTech Int Corp, Hlth & Life Sci, Herndon, VA 20171 USA. RP Piccirillo, AL (reprint author), Walter Reed Army Inst Res, Prevent Med Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM amanda.l.piccirillo.ctr@mail.mil FU Defense Health Program FX This study was supported by funds provided by the Defense Health Program. NR 37 TC 0 Z9 0 U1 1 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-3956 EI 1879-1379 J9 J PSYCHIATR RES JI J. Psychiatr. Res. PD DEC PY 2015 VL 71 BP 56 EP 62 DI 10.1016/j.jpsychires.2015.09.010 PG 7 WC Psychiatry SC Psychiatry GA CW5RI UT WOS:000365053900007 PM 26522872 ER PT J AU Clark, ME Woo, RK Johnson, SM AF Clark, Margaret E. Woo, Russell K. Johnson, Sidney M. TI Thoracoscopic pleural clipping for the management of congenital chylothorax SO PEDIATRIC SURGERY INTERNATIONAL LA English DT Article DE Chylothorax; Chyle leak; Thoracic duct; Neonate; Parietal clipping; Pleurodesis ID IDIOPATHIC CHYLOTHORAX; THORACIC-DUCT; EFFUSIONS; LIGATION AB Medical management of congenital chylothoraces consists of total parental nutrition and tube thoracostomy. However, these infants are exposed to significant fluid shifts and the related leukopenia carries a high infection risk. The purpose of this review is to describe the technique of parietal pleural clipping as a surgical treatment of congenital chylothorax. The medical records of all patients with a chylothorax diagnosis during the study period of January 2002 to April 2014 were retrospectively reviewed. Six of 14 infants identified underwent thoracoscopic parietal pleural clipping to disrupt the pleural lymphatic channel flow as visualization of the thoracic duct and lymphatics was not possible. Nearly all surgical patients had bilateral disease (5/6). Resolution of chylous leakage was dramatic following parietal clipping. In the surgical patients, chest tube output 2 days prior to surgery averaged 86.96 ml/kg/day. After parietal clipping, chest tube output dropped to an average of 6.5 ml/kg/day on post op day 2. Thereafter, chest tube output remained low to negligible and chest tubes were removed variably as enteral feeds were started. We describe a straightforward technique of thoracoscopic parietal pleural clipping as a safe and successful option for treatment of congenital chylothoraces. C1 [Clark, Margaret E.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. [Woo, Russell K.; Johnson, Sidney M.] Univ Hawaii, Kapiolani Med Ctr, Dept Pediat Surg, Honolulu, HI 96822 USA. RP Clark, ME (reprint author), Tripler Army Med Ctr, Dept Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM margaret.elise.clark@gmail.com NR 15 TC 0 Z9 1 U1 2 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0179-0358 EI 1437-9813 J9 PEDIATR SURG INT JI Pediatr. Surg. Int. PD DEC PY 2015 VL 31 IS 12 BP 1133 EP 1137 DI 10.1007/s00383-015-3760-6 PG 5 WC Pediatrics; Surgery SC Pediatrics; Surgery GA CW6BL UT WOS:000365081900004 PM 26276425 ER PT J AU Crone, JC Munday, LB Knap, J AF Crone, Joshua C. Munday, Lynn B. Knap, Jaroslaw TI Capturing the effects of free surfaces on void strengthening with dislocation dynamics SO ACTA MATERIALIA LA English DT Article DE Discrete dislocation dynamics; Void strengthening; Surface effects ID CENTERED-CUBIC METALS; SIMULATIONS; FCC; MECHANISMS; CRYSTALS; STRESS; MODEL; IRON; DRAG; BCC AB Void strengthening in crystalline materials refers to the increase in yield stress due to the impediment of dislocation motion by voids. Dislocation dynamics (DD) is a modeling method well suited to capture the physics, length scales, and time scales associated with void strengthening. However, previous DD simulation of dislocation void interactions have been unable to accurately account for the strong image forces acting on the dislocation due to the void's free surface. In this article, we employ a finite-element-based DD method to determine the obstacle strength of voids, defined as the critical resolved shear stress for a dislocation to glide past an array of voids. Our results demonstrate that the attractive image forces between the dislocation and free surface significantly reduce the obstacle strength of voids. Effects of surface mobility and stress concentrations around the void are also explored and are shown to have minimal effect on the critical stress. Finally, a new model relating void size and spacing to obstacle strength is proposed. Published by Elsevier Ltd. on behalf of Acta Materialia Inc. C1 [Crone, Joshua C.; Munday, Lynn B.; Knap, Jaroslaw] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Crone, JC (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM joshua.crone.civ@mail.mil FU U.S. Army Research Laboratory's Enterprise for Multiscale Research of Materials FX Support of the U.S. Army Research Laboratory's Enterprise for Multiscale Research of Materials is gratefully acknowledged. Computing support was provided by the DoD Supercomputing Resource Center located at the U.S. Army Research Laboratory. NR 36 TC 3 Z9 3 U1 0 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6454 EI 1873-2453 J9 ACTA MATER JI Acta Mater. PD DEC PY 2015 VL 101 BP 40 EP 47 DI 10.1016/j.actamat.2015.08.067 PG 8 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA CV4RN UT WOS:000364254300006 ER PT J AU Booth, DB Fischenich, CJ AF Booth, Derek B. Fischenich, Craig J. TI A channel evolution model to guide sustainable urban stream restoration SO AREA LA English DT Article DE urban streams; channel evolution models; restoration; sustainability; geomorphology ID SOUTHERN CALIFORNIA; RIPARIAN-CORRIDOR; RIVER; URBANIZATION; WATERSHEDS; EROSION; USA; HYDROMODIFICATION; REHABILITATION; CLASSIFICATION AB Channel evolution models (CEMs) are used to structure the interpretation of observed channel morphology to support long-term restoration of these systems. However, channels reflect the variety of their watersheds' climatological, ecological and physiographic contexts, and so no single CEM can be truly global'. Unrecognised differences between the assumptions and the reality of evolutionary trajectories of particular streams can subsequently lead to restoration actions that neither fully achieve their intended objectives nor successfully self-maintain even limited improvements. Despite the daunting variety of biophysical settings, however, urbanisation imposes distinctive, homogenising influences on virtually all watercourses, suggesting that even a relatively small set of evolutionary pathways can embrace much of the diversity of critical watershed drivers on urban channels. CEMs describing single-thread channel response to incision are most common in the published literature, but not every urban disturbance yields this classic sequence, initiated by excess transport capacity followed by incision, bank erosion, widening and ultimately a lowered re-equilibrated channel. A comprehensive urban CEM must also include responses under less common (but locally ubiquitous) conditions, such as excess sediment relative to transport capacity (the inverse' of the classic CEM), imposed constraints on vertical and/or lateral adjustment, and multi-thread channels or those influenced by instream or riparian vegetation. An urban CEM also requires a hierarchical framework that acknowledges fundamental differences in the process drivers within any given watershed, because a single observation of channel form can rarely pinpoint the context or evolutionary trajectory of every stream. We present a geomorphic framework for diagnosing and predicting the evolution of urban streams, potentially guiding the selection of restoration targets that are achievable within an urban context and sustainable without ongoing maintenance. C1 [Booth, Derek B.] Univ Calif Santa Barbara, Bren Sch Environm Sci & Management, Santa Barbara, CA 93106 USA. [Fischenich, Craig J.] US Army Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Booth, DB (reprint author), Univ Calif Santa Barbara, Bren Sch Environm Sci & Management, Santa Barbara, CA 93106 USA. EM dbooth@bren.ucsb.edu FU Ecosystem Management and Restoration Research Program through US Army Corps of Engineers [W912HZ-12-2-0016]; Ecosystem Management and Restoration Research Program through UC Santa Barbara [W912HZ-12-2-0016] FX Our thanks to colleagues Sarah Miller, Jock Cunningham, Dan Baker and five anonymous journal reviewers whose suggestions greatly improved the quality of this paper. This work was supported under the Ecosystem Management and Restoration Research Program through Cooperative Agreement W912HZ-12-2-0016 between the US Army Corps of Engineers and UC Santa Barbara. NR 56 TC 6 Z9 6 U1 8 U2 31 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0004-0894 EI 1475-4762 J9 AREA JI Area PD DEC PY 2015 VL 47 IS 4 BP 408 EP 421 DI 10.1111/area.12180 PG 14 WC Geography SC Geography GA CV9YJ UT WOS:000364644500007 ER PT J AU Holloway, TL Rani, M Cap, AP Stewart, RM Schwacha, MG AF Holloway, Travis L. Rani, Meenakshi Cap, Andrew P. Stewart, Ronald M. Schwacha, Martin G. TI The association between the Th-17 immune response and pulmonary complications in a trauma ICU population SO CYTOKINE LA English DT Article DE Acute lung injury; IL-17; Acute respiratory distress syndrome; Inflammation; Injury ID ACUTE LUNG INJURY; RESPIRATORY-DISTRESS-SYNDROME; IL-17 FAMILY CYTOKINES; CELL LINEAGES; T-CELL; INFLAMMATION; EXPRESSION AB Background: The overall immunopathology of the T-helper cell (Th)-17 immune response has been implicated in various inflammatory diseases including pulmonary inflammation; however its potential role in acute respiratory distress syndrome (ARDS) is not defined. This study aimed to evaluate the Th-17 response in bronchoalveolar lavage fluid (BALF) and blood and from trauma patients with pulmonary complications. Methods: A total of 21 severely injured intensive care unit (ICU) subjects, who were mechanically ventilated and undergoing bronchoscopy, were enrolled. BALF and blood were collected and analyzed for Th-1 (interferon [IFN]gamma), Th-2 (interleukin [IL]-4, -10), Th-17 (IL-17A, -17F, -22, 23) and pro-inflammatory (IL-1 beta, IL-6, tumor necrosis factor [TNF]alpha) cytokine levels. Results: Significant levels of the Th-17 cytokines IL-17A, -17F and -21 and IL-6 (which can be classified as a Th-17 cytokine) were observed in the BALF of all subjects. There were no significant differences in Th-17 cytokines between those subjects with ARDS and those without, with the exception of plasma and BALE IL-6, which was markedly greater in ARDS subjects, as compared with controls and non-ARDS subjects. Conclusions: Trauma patients with pulmonary complications exhibited a significant Th-17 response in the lung and blood, suggesting that this pro-inflammatory milieu may be a contributing factor to such complications. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Holloway, Travis L.; Rani, Meenakshi; Stewart, Ronald M.; Schwacha, Martin G.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA. [Cap, Andrew P.; Schwacha, Martin G.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Schwacha, MG (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, Mail Code 7740,7703 Floyd Curl Dr, San Antonio, TX 78229 USA. EM schwacha@uthscsa.edu FU UTHSCSA Department of Surgery NIH T32 Training Grant NIH Grant [5T32GM079085]; NIH/NCRR UL [1RR025767]; NIH-NCI [P30 CA54174]; [UL1RR025767] FX TLH was supported under the UTHSCSA Department of Surgery NIH T32 Training Grant NIH Grant (5T32GM079085) and the project was in part supported by NIH/NCRR UL 1RR025767, NIH-NCI P30 CA54174 and UL1RR025767. NR 31 TC 2 Z9 2 U1 0 U2 2 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 1043-4666 EI 1096-0023 J9 CYTOKINE JI Cytokine PD DEC PY 2015 VL 76 IS 2 BP 328 EP 333 DI 10.1016/j.cyto.2015.09.003 PG 6 WC Biochemistry & Molecular Biology; Cell Biology; Immunology SC Biochemistry & Molecular Biology; Cell Biology; Immunology GA CV4NS UT WOS:000364244400028 PM 26364992 ER PT J AU Kore, I Ananworanich, J Valcour, V Fletcher, JLK Chalermchai, T Paul, R Reynolds, J Tipsuk, S Ubolyam, S Rattanamanee, S Jagodzinski, L Kim, J Spudich, S AF Kore, Idil Ananworanich, Jintanat Valcour, Victor Fletcher, James L. K. Chalermchai, Thep Paul, Robert Reynolds, Jesse Tipsuk, Somporn Ubolyam, Sasiwimol Rattanamanee, Somprartthana Jagodzinski, Linda Kim, Jerome Spudich, Serena CA RV254 SEARCH 010 Study Grp TI Neuropsychological Impairment in Acute HIV and the Effect of Immediate Antiretroviral Therapy SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE HIV infection; HIV-associated neurocognitive disorder; neuropsychological tests; mild cognitive impairment; antiretroviral therapy ID NEUROCOGNITIVE IMPAIRMENT; INFECTED PERSONS; PREVALENCE; DISORDERS; ERA; RISK; PERFORMANCE; NADIR AB Objective:To investigate neuropsychological performance (NP) during acute HIV infection (AHI) before and after combination antiretroviral therapy (cART). Design: Prospective study of Thai AHI participants examined at 3 and 6 months after initiation of cART. Methods: Thirty-six AHI participants were evaluated pre-cART at median 19 days since HIV exposure and 3 and 6 months after cART with the Grooved Pegboard test, Color Trails 1 & 2 (CT1, CT2), and Trail Making Test A. Raw scores were standardized to 251 age- and education-matched HIV-uninfected Thais. To account for learning effects, change in NP performance was compared with that of controls at 6 months. Analyses included multivariable regression, nonparametric repeated measures analysis of variance, and Mann-Whitney U test. Results: Baseline NP scores for the AHI group were within normal range (z-scores range: -0.26 to -0.13). NP performance improved on CT1, CT2, and Trail Making Test A in the initial 3 months (P < 0.01) with no significant change during the last 3 months. Only improvement in CT1 was greater than that seen in controls at 6 months (P = 0.018). Participants who performed >1 SD below normative means on 2 tests (n = 8) exhibited higher baseline cerebrospinal fluid HIV RNA (P = 0.047) and had no improvement after cART. Conclusions: Most AHI individuals had normal NP performance, and early cART slightly improved their psychomotor function. However, approximately 25% had impaired NP performance, which correlated with higher cerebrospinal fluid HIV RNA, and these abnormalities were not reversed by early cART possibly indicating limited reversibility of cognitive impairment in a subset of AHI individuals. C1 [Kore, Idil; Spudich, Serena] Yale Univ, Sch Med, New Haven, CT 06520 USA. [Ananworanich, Jintanat; Fletcher, James L. K.; Chalermchai, Thep; Tipsuk, Somporn; Rattanamanee, Somprartthana; Kim, Jerome] Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, Thailand. [Ananworanich, Jintanat; Jagodzinski, Linda; Kim, Jerome] US Mil HIV Res Program, Walter Reed Army Inst Res, Silver Spring, MD USA. [Ananworanich, Jintanat; Jagodzinski, Linda; Kim, Jerome] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Valcour, Victor] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Paul, Robert] Univ Missouri, Missouri Inst Mental Hlth, St Louis, MO 63121 USA. [Reynolds, Jesse] Yale Ctr Analyt Sci, New Haven, CT USA. [Ubolyam, Sasiwimol] Thai Red Cross AIDS Res Ctr, HIV NAT, Bangkok, Thailand. RP Spudich, S (reprint author), Yale Univ, Dept Neurol, POB 208018, New Haven, CT 06520 USA. EM serena.spudich@yale.edu FU National Institutes of Health [R01MH095613, R21MH086341, R01MH09561302-S1, R01NS061696]; US Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, MD [W81XWH-07-2-0067]; Yale School of Medicine Office of Student Research; Thai Government Pharmaceutical Organization; Gilead; Merck; ViiV Healthcare; [R01MH09561302- S1] FX S.S. has received travel support and an honorarium for presentation at a scientific meeting from Abbvie, Inc. These studies were funded by the National Institutes of Health (R01MH095613, R21MH086341, R01MH09561302-S1, R01NS061696) and the US Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, MD, under a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the US Department of Defense. I.K. was directly supported by R01MH09561302- S1 and the Yale School of Medicine Office of Student Research. Antiretrovirals were supported by the Thai Government Pharmaceutical Organization, Gilead, Merck, and ViiV Healthcare. Monogram Biosciences supported the Trofile test. The content of this presentation is solely the responsibility of the authors and does not necessarily represent the official views of any of the institutions mentioned above. NR 31 TC 6 Z9 6 U1 2 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD DEC 1 PY 2015 VL 70 IS 4 BP 393 EP 399 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CV5MZ UT WOS:000364316300009 PM 26509933 ER PT J AU Hakre, S Scoville, SL Pacha, LA Peel, SA Kim, JH Michael, NL Cersovsky, SB Scott, PT AF Hakre, Shilpa Scoville, Stephanie L. Pacha, Laura A. Peel, Sheila A. Kim, Jerome H. Michael, Nelson L. Cersovsky, Steven B. Scott, Paul T. TI Sexual Risk Behaviors of HIV Seroconverters in the US Army, 2012-2014 SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE HIV; US Army; surveillance; MSM ID WHITE MEN; PARTNER SELECTION; BLACK; DISPARITIES; INFECTION; METAANALYSIS AB The United States (US) Army implemented a comprehensive HIV characterization program in 2012 following repeal of the Don't Ask, Don't Tell policy banning openly homosexual individuals from serving in the US military. Program staff administered a standardized case report form to soldiers newly diagnosed with HIV from 2012 to 2014 in compliance with new program requirements. The case report form documented sociodemographic, sexual, and other risk behavior information elicited from US Army regulation-mandated epidemiologic interviews at initial HIV notification. A majority of HIV-infected soldiers were male and of black/African American racial origin. In the HIV risk period, male soldiers commonly reported male-male sexual contact, civilian partners, online partner-seeking, unprotected anal sex, and expressed surprise at having a positive HIV result. Don't Ask, Don't Tell repeal allows for risk screening and reduction interventions targeting a newly identifiable risk category in the US Army. At-risk populations need to be identified and assessed for possible unmet health needs. C1 [Hakre, Shilpa] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Bethesda, MD USA. [Scoville, Stephanie L.; Pacha, Laura A.; Cersovsky, Steven B.] US Army, Publ Hlth Command, Aberdeen Proving Ground, MD USA. [Peel, Sheila A.; Kim, Jerome H.; Michael, Nelson L.; Scott, Paul T.] Walter Reed Army Inst Res, US Mil HIV Res Program, Bethesda, MD USA. RP Hakre, S (reprint author), US Mil HIV Res Program, Dept Epidemiol & Threat Assessment, 6720-A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA. EM shakre@hivresearch.org FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc [W81XWH-07-2-0067]; US Department of Defense FX Supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, and the US Department of Defense. NR 23 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD DEC 1 PY 2015 VL 70 IS 4 BP 456 EP 461 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CV5MZ UT WOS:000364316300018 PM 26247893 ER PT J AU Pittari, J Subhash, G Zheng, J Halls, V Jannotti, P AF Pittari, John, III Subhash, Ghatu Zheng, James Halls, Virginia Jannotti, Phillip TI The rate-dependent fracture toughness of silicon carbide- and boron carbide-based ceramics SO JOURNAL OF THE EUROPEAN CERAMIC SOCIETY LA English DT Article DE Fracture toughness; Chevron notch; Reaction bonding; Silicon carbide; Boron carbide ID SIC-SI COMPOSITES; ARMOR CERAMICS; BALLISTIC PERFORMANCE; MECHANICAL-PROPERTIES; BRITTLE MATERIALS; MICROSTRUCTURES; STRENGTH; SPECIMENS; BEHAVIOR; HARDNESS AB Thirteen silicon carbide and boron carbide ceramics and ceramic composites manufactured through pressureless sintering and reaction bonding techniques have been tested in a four-point bend, chevron notch testing procedure to determine their static and dynamic fracture toughness values. Dynamic fracture toughness testing was performed in a modified Hopkinson pressure bar to investigate the effect of high-rate loading on fracture toughness values and fracture characteristics. Fracture surfaces were investigated through optical profilometry and scanning electron microscopy to examine the surface roughness and fracture morphology. Reaction-bonded ceramic composites were found to have elevated fracture toughness values compared to pressureless-sintered ceramics. This enhancement is attributed to a change in fracture mode of the reaction-bonded materials and processing-induced residual compressive stresses within the silicon phase. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Pittari, John, III; Jannotti, Phillip] US Army Res Lab, Aberdeen, MD 21005 USA. [Subhash, Ghatu] Univ Florida, Mech & Aerosp Engn, Gainesville, FL 32611 USA. [Zheng, James; Halls, Virginia] US Army, Program Execut Off Solider, Ft Belvoir, VA 22060 USA. RP Subhash, G (reprint author), 225-A MAE A,POB 116250, Gainesville, FL 32611 USA. EM subhash@ufl.edu NR 56 TC 3 Z9 3 U1 9 U2 39 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0955-2219 EI 1873-619X J9 J EUR CERAM SOC JI J. Eur. Ceram. Soc. PD DEC PY 2015 VL 35 IS 16 BP 4411 EP 4422 DI 10.1016/j.jeurceramsoc.2015.08.027 PG 12 WC Materials Science, Ceramics SC Materials Science GA CV4SU UT WOS:000364257600006 ER PT J AU Hall, AO Fu, MC AF Hall, Andrew O. Fu, Michael C. TI Optimal Army officer force profiles SO OPTIMIZATION LETTERS LA English DT Article DE Military manpower modeling; Mathematical programming; Networks ID MODEL AB We explore the optimization of US Army officer force profiles. An officer force profile describes the distribution of rank and specialty as well as age and experience within the officer corps. There are two different force profiles, the one that dictates the requirements or targets for a given force structure and one that defines the current population. We explore and optimize a force profile that meets current and future force structure requirements while incorporating information from the current and historical officer population. We propose a new network structure that incorporates both rank and years in grade to combine cohort, rank, and specialty modeling without falling into the common pitfalls of small cell size and uncontrollable end effects. This research is the first to address specialty and experience modeling in a manpower and force development model for US Army officers, modeling the entire officer's career and developing an optimal force profile. C1 [Hall, Andrew O.] US Mil Acad, West Point, NY 10996 USA. [Fu, Michael C.] Univ Maryland, RH Smith Sch Business, College Pk, MD 20742 USA. [Fu, Michael C.] Univ Maryland, Syst Res Inst, College Pk, MD 20742 USA. RP Hall, AO (reprint author), US Mil Acad, West Point, NY 10996 USA. EM halla@acm.org NR 12 TC 0 Z9 0 U1 0 U2 3 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1862-4472 EI 1862-4480 J9 OPTIM LETT JI Optim. Lett. PD DEC PY 2015 VL 9 IS 8 BP 1769 EP 1785 DI 10.1007/s11590-015-0947-7 PG 17 WC Operations Research & Management Science; Mathematics, Applied SC Operations Research & Management Science; Mathematics GA CW0VN UT WOS:000364708000018 ER PT J AU Shuffler, ML Jimenez-Rodriguez, M Kramer, WS AF Shuffler, Marissa L. Jimenez-Rodriguez, Miliani Kramer, William S. TI The Science of Multiteam Systems: A Review and Future Research Agenda SO SMALL GROUP RESEARCH LA English DT Review DE multiteam systems; multilevel; intergroup dynamics ID PERSPECTIVE; TEAMS; COLLABORATION; LEADERSHIP; SUBGROUPS; CARE AB Given the complexities of today's workplace, organizations and agencies are progressively turning toward interdependent systems comprised of teams, or multiteam systems (MTSs), to accomplish multifaceted tasks in challenging environments. Subsequently, MTSs have grown in popularity in group and team research, spanning a breath of disciplines (psychology, organizational behavior, human factors, communication, and medicine). In this review, our goal is to highlight the existing research across a range of disciplines regarding MTSs that serves to answer the question, What do we know about MTSs? while also developing a future research agenda aimed at answering the question, Where does our research need to go to better understand MTSs? We specifically highlight the current trends, dynamics, and methodological issues in MTSs to further build the foundation for improving MTS effectiveness. C1 [Shuffler, Marissa L.] Clemson Univ, Ind Org Psychol, Clemson, SC 29634 USA. [Kramer, William S.] Clemson Univ, IO Psychol Program, Clemson, SC 29634 USA. [Jimenez-Rodriguez, Miliani] US Army, Res Inst Behav & Social Sci, Ft Leavenworth, KS USA. RP Shuffler, ML (reprint author), Clemson Univ, 418 Brackett Hall, Clemson, SC 29634 USA. EM MSHUFFL@clemson.edu FU NASA [NNJ15HK12P] FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was partially supported by the NASA grant (NNJ15HK12P) to Dr. Marissa Shuffler, Principal Investigator. The views expressed in this work are those of the authors and do not necessarily reflect the organizations with which they are affiliated or their sponsoring institutions or agencies. NR 68 TC 7 Z9 7 U1 10 U2 25 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1046-4964 EI 1552-8278 J9 SMALL GR RES JI Small Group Res. PD DEC PY 2015 VL 46 IS 6 SI SI BP 659 EP 699 DI 10.1177/1046496415603455 PG 41 WC Psychology, Applied; Management; Psychology, Social SC Psychology; Business & Economics GA CW3UI UT WOS:000364917000004 ER PT J AU Li, XH Li, PC Ji, L Stender, C Tatavarti, SR Sablon, K Yu, ET AF Li, Xiaohan Li, Ping-Chun Ji, Li Stender, Christopher Tatavarti, Sudersena Rao Sablon, Kimberly Yu, Edward T. TI Integration of subwavelength optical nanostructures for improved antireflection performance of mechanically flexible GaAs solar cells fabricated by epitaxial lift-off SO SOLAR ENERGY MATERIALS AND SOLAR CELLS LA English DT Article DE Antireflection; Epitaxial lift-off; Flexible; Omnidirectional; Solar cells ID BROAD-BAND; FILM; ARRAYS; GLASS AB We demonstrate the integration of subwavelength moth-eye and Al2O3 nanoisland structures fabricated on polymer packaging sheets and the surface of conventional Al2O3/TiO2 bilayer antireflection coatings, respectively, with epitaxial lift-off single-junction GaAs solar cells. The mechanically flexible cell structure with the integrated optical nanostructures shows substantially improved photovoltaic performance under various incident angles and bending radii compared to devices without such structures: the increase in short-circuit current density arising from integration of these nanostructures ranges from 9% at normal incidence to 52% at 80 degrees incidence; and the reduction in short-circuit current density under moderate bending decreases from 9.7% to 6.7%. (C) 2015 Elsevier B.V. All rights reserved. C1 [Li, Xiaohan; Li, Ping-Chun; Ji, Li; Yu, Edward T.] Univ Texas Austin, Microelect Res Ctr, Austin, TX 78758 USA. [Stender, Christopher; Tatavarti, Sudersena Rao] Microlink Devices Inc, Niles, IL 60714 USA. [Sablon, Kimberly] US Army Res Lab, Adelphi, MD 20783 USA. RP Li, XH (reprint author), Univ Texas Austin, Microelect Res Ctr, 10100 Burnet Rd, Austin, TX 78758 USA. EM xhli@utexas.edu; ety@ece.utexas.edu RI Yu, Edward/A-3515-2017 OI Yu, Edward/0000-0001-9900-7322 FU U.S. Army Research Laboratory; National Science Foundation [ECCS-1120832, DMR-1311866]; Judson S. Swearingen Regents Chair in Engineering at the University of Texas at Austin FX Part of this work was supported by the U.S. Army Research Laboratory, the National Science Foundation (ECCS-1120832 and DMR-1311866), and the Judson S. Swearingen Regents Chair in Engineering at the University of Texas at Austin. NR 32 TC 0 Z9 0 U1 6 U2 25 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0927-0248 EI 1879-3398 J9 SOL ENERG MAT SOL C JI Sol. Energy Mater. Sol. Cells PD DEC PY 2015 VL 143 BP 567 EP 572 DI 10.1016/j.solmat.2015.08.006 PG 6 WC Energy & Fuels; Materials Science, Multidisciplinary; Physics, Applied SC Energy & Fuels; Materials Science; Physics GA CV4PY UT WOS:000364250200076 ER PT J AU Haider, AH Piper, LC Zogg, CK Schneider, EB Orman, JA Butler, FK Gerhardt, RT Haut, ER Mather, JP MacKenzie, EJ Schwartz, DA Geyer, DW DuBose, JJ Rasmussen, TE Blackbourne, LH AF Haider, Adil H. Piper, Lydia C. Zogg, Cheryl K. Schneider, Eric B. Orman, Jean A. Butler, Frank K. Gerhardt, Robert T. Haut, Elliott R. Mather, Jacques P. MacKenzie, Ellen J. Schwartz, Diane A. Geyer, David W. DuBose, Joseph J. Rasmussen, Todd E. Blackbourne, Lorne H. TI Military-to-civilian translation of battlefield innovations in operative trauma care SO SURGERY LA English DT Article ID COMBAT CASUALTY CARE; DAMAGE CONTROL RESUSCITATION; RED-BLOOD-CELLS; VASCULAR ACCESS; CURRENT WAR; TRANSFUSION; TOURNIQUETS; PLASMA; DECADE; RATIO AB Background. Historic improvements in operative trauma care have been driven by war. It is unknown whether recent battlefield innovations stemming from conflicts in Iraq/Afghanistan will follow a similar trend. The objective of this study was to survey trauma medical directors (TMDs) at level 1-3 trauma centers across the United States and gauge the extent to which battlefield innovations have shaped civilian practice in 4 key domains of trauma care. Methods. Domains were determined by the use of a modified Delphi method based on multiple consultations with an expert physician/surgeon panel: (I) damage control resuscitation (DCR), (2) tourniquet use, (3) use of hemostatic agents, and (4) prehospital interventions, including intraosseous catheter access and needle thoracostomy. A corresponding 47-item electronic anonymous survey was developed/pilot tested before dissemination to all identifiable TMD at level 1-3 trauma centers across the US. Results. A total of 245 TMDs, representing nearly 40% of trauma centers in the United States, completed and returned the survey. More than half (n = 127; 51.8 %) were verified by the American College of Surgeons. TMDs reported high civilian use of DCR: 95.1% of trauma centers had implemented massive transfusion protocols and the majority (67.7%) tended toward 1:1:1 packed red blood cell/fresh-frozen plasma/platelets ratios. For the other 3, mixed adoption corresponded to expressed concerns regarding the extent of concomitant civilian research to support military research and experience. In centers in which policies reflecting battlefield innovations were in use, previous military experience frequently was acknowledged. Conclusion. This national survey of TMDs suggests that military data supporting DCR has altered civilian practice. Perceived relevance in other domains was less clear. Civilian academic efforts are needed to further research and enhance understandings that foster improved trauma surgeon awareness of military-to-civilian translation. C1 [Haider, Adil H.; Zogg, Cheryl K.] Harvard Univ, Sch Med, Ctr Surg & Publ Hlth, Boston, MA USA. [Haider, Adil H.; Zogg, Cheryl K.] Harvard Univ, Sch Publ Hlth, Dept Surg, Brigham & Womens Hosp, Boston, MA 02115 USA. [Piper, Lydia C.; Schneider, Eric B.; Haut, Elliott R.; Schwartz, Diane A.] Johns Hopkins Univ, Sch Med, Dept Surg, Baltimore, MD 21205 USA. [Orman, Jean A.] Uniformed Serv Univ Hlth Sci, Dept Med, Washington, DC USA. [Butler, Frank K.] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD 20814 USA. [Gerhardt, Robert T.] Brooke Army Med Ctr, Dept Emergency Med, Houston, TX USA. [Mather, Jacques P.] Univ Miami, Jackson Mem Med Ctr, Dept Gen Surg, Miami, FL USA. [MacKenzie, Ellen J.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, Baltimore, MD USA. [Geyer, David W.] Reading Hlth Syst, Dept Anesthesiol, W Reading, PA USA. [DuBose, Joseph J.; Rasmussen, Todd E.] Univ Maryland, Sch Med, Dept Surg, Baltimore, MD 21201 USA. [Blackbourne, Lorne H.] Brooke Army Med Ctr, Dept Surg, Houston, TX USA. RP Haider, AH (reprint author), Brigham & Womens Hosp, Ctr Surg & Publ Hlth, 1620 Tremont St,One Brigham Circle,4th Floor, Boston, MA 02120 USA. EM ahhaider@partners.org NR 41 TC 7 Z9 7 U1 2 U2 14 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0039-6060 J9 SURGERY JI Surgery PD DEC PY 2015 VL 158 IS 6 BP 1687 EP 1696 DI 10.1016/j.surg.2015.06.026 PG 10 WC Surgery SC Surgery GA CV9MV UT WOS:000364612200028 PM 26210224 ER PT J AU Farlow, KG Day, MV AF Farlow, Kasie G. Day, Martin V. TI A Characterization of the Reflected Quasipotential SO APPLIED MATHEMATICS AND OPTIMIZATION LA English DT Article ID HAMILTON-JACOBI EQUATIONS; PARTIAL-DIFFERENTIAL-EQUATIONS; OBLIQUE DERIVATIVE PROBLEMS; BOUNDARY-CONDITIONS; VISCOSITY SOLUTIONS; NONSMOOTH DOMAINS; SYSTEMS; GAMES AB Recent interest in the reflected quasipotential comes from the queueing theory literature, specifically the analysis of so-called reflected Brownian motion where it is the large deviation rate function for the stationary distribution. Our purpose here is to characterize the reflected quasipotential in terms of a first-order Hamilton-Jacobi equation. Using conventional dynamic programming ideas, along with a complementarity problem formulation of the effect of the Skorokhod map on absolutely continuous paths, we will derive necessary conditions in the form of viscosity-sense boundary conditions. It turns out that even with these boundary conditions solutions are not unique. Thus a unique characterization needs to refer to some additional property of . We establish such a characterization in two dimensions. C1 [Farlow, Kasie G.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Day, Martin V.] Virginia Tech, Dept Math, Blacksburg, VA 24060 USA. RP Farlow, KG (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. EM kasie.farlow@usma.edu; daymv@math.vt.edu NR 35 TC 1 Z9 1 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0095-4616 EI 1432-0606 J9 APPL MATH OPT JI Appl. Math. Optim. PD DEC PY 2015 VL 72 IS 3 BP 435 EP 468 DI 10.1007/s00245-014-9286-9 PG 34 WC Mathematics, Applied SC Mathematics GA CV2ZR UT WOS:000364128300003 ER PT J AU Harmata, A Ma, Y Sanchez, C Zienkiewicz, K Elefteriou, F Wenke, J Guelcher, S AF Harmata, Andrew J. Ma, Yun Sanchez, Carlos J. Zienkiewicz, Katarzyna J. Elefteriou, Florent Wenke, Joseph C. Guelcher, Scott A. TI D-amino Acid Inhibits Biofilm but not New Bone Formation in an Ovine Model SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Article ID IN-VITRO; STAPHYLOCOCCUS-AUREUS; POLYURETHANE SCAFFOLDS; TIBIAL FRACTURES; GROWTH-FACTOR; INFECTION; COMBAT; WOUNDS; SUSCEPTIBILITY; COMPLICATIONS AB Background Infectious complications of musculoskeletal trauma are an important factor contributing to patient morbidity. Biofilm-dispersive bone grafts augmented with d-amino acids (d-AAs) prevent biofilm formation in vitro and in vivo, but the effects of d-AAs on osteocompatibility and new bone formation have not been investigated. Questions/purposes We asked: (1) Do d-AAs hinder osteoblast and osteoclast differentiation in vitro? (2) Does local delivery of d-AAs from low-viscosity bone grafts inhibit new bone formation in a large-animal model? Methods Methicillin-sensitive Staphylococcus aureus and methicillin-resistant S aureus clinical isolates, mouse bone marrow stromal cells, and osteoclast precursor cells were treated with an equal mass (1:1:1) mixture of d-Pro:d-Met:d-Phe. The effects of the d-AA dose on biofilm inhibition (n = 4), biofilm dispersion (n = 4), and bone marrow stromal cell proliferation (n = 3) were quantitatively measured by crystal violet staining. Osteoblast differentiation was quantitatively assessed by alkaline phosphatase staining, von Kossa staining, and quantitative reverse transcription for the osteogenic factors a1Col1 and Ocn (n = 3). Osteoclast differentiation was quantitatively measured by tartrate-resistant acid phosphatase staining (n = 3). Bone grafts augmented with 0 or 200 mmol/L d-AAs were injected in ovine femoral condyle defects in four sheep. New bone formation was evaluated by mu CT and histology 4 months later. An a priori power analysis indicated that a sample size of four would detect a 7.5% difference of bone volume/total volume between groups assuming a mean and SD of 30% and 5%, respectively, with a power of 80% and an alpha level of 0.05 using a two-tailed t-test between the means of two independent samples. Results Bone marrow stromal cell proliferation, osteoblast differentiation, and osteoclast differentiation were inhibited at d-AAs concentrations of 27 mmol/L or greater in a dose-responsive manner in vitro (p < 0.05). In methicillin-sensitive and methicillin-resistant S aureus clinical isolates, d-AAs inhibited biofilm formation at concentrations of 13.5 mmol/L or greater in vitro (p < 0.05). Local delivery of d-AAs from low-viscosity grafts did not inhibit new bone formation in a large-animal model pilot study (0 mmol/L d-AAs: bone volume/total volume = 26.9% +/- 4.1%; 200 mmol/L d-AAs: bone volume/total volume = 28.3% +/- 15.4%; mean difference with 95% CI = -1.4; p = 0.13). Conclusions D-AAs inhibit biofilm formation, bone marrow stromal cell proliferation, osteoblast differentiation, and osteoclast differentiation in vitro in a dose-responsive manner. Local delivery of d-AAs from bone grafts did not inhibit new bone formation in vivo at clinically relevant doses. C1 [Harmata, Andrew J.; Zienkiewicz, Katarzyna J.; Guelcher, Scott A.] Vanderbilt Univ, Dept Chem & Biomol Engn, Nashville, TN 37235 USA. [Harmata, Andrew J.; Ma, Yun; Elefteriou, Florent; Guelcher, Scott A.] Vanderbilt Univ Sch Med, Ctr Bone Biol, Nashville, TN USA. [Guelcher, Scott A.] Vanderbilt Univ, Dept Biomed Engn, Nashville, TN 37235 USA. [Sanchez, Carlos J.; Wenke, Joseph C.] US Army, Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, San Antonio, TX USA. [Ma, Yun; Elefteriou, Florent] Vanderbilt Univ Sch Med, Dept Med, Div Clin Pharmacol, Nashville, TN USA. [Elefteriou, Florent] Vanderbilt Univ Sch Med, Dept Pharmacol, Nashville, TN USA. [Elefteriou, Florent] Vanderbilt Univ Sch Med, Dept Canc Biol, Nashville, TN USA. RP Guelcher, S (reprint author), Vanderbilt Univ, Dept Chem & Biomol Engn, 2400 Highland Ave,107 Olin Hall, Nashville, TN 37235 USA. EM Scott.Guelcher@vanderbilt.edu FU Orthopaedic Extremity Trauma Research Program; National Institute of Arthritis and Musculoskeletal Diseases; Medtronic, Inc; Oak Ridge Institute; National Institutes of Health FX The institution of one or more of the authors (SAG, FE, JCW) has received, during the study period, funding from the Orthopaedic Extremity Trauma Research Program (SAG and JCW), the National Institute of Arthritis and Musculoskeletal Diseases (SAG, JCW, and FE), Medtronic, Inc (SAG); Oak Ridge Institute (AJH); and the National Institutes of Health (SAG). NR 56 TC 1 Z9 1 U1 2 U2 18 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0009-921X EI 1528-1132 J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD DEC PY 2015 VL 473 IS 12 BP 3951 EP 3961 DI 10.1007/s11999-015-4465-9 PG 11 WC Orthopedics; Surgery SC Orthopedics; Surgery GA CV3GF UT WOS:000364146300045 PM 26201421 ER PT J AU Adali, S Chan, K Cho, JH AF Adali, Sibel Chan, Kevin Cho, Jin-Hee TI TANDEM: a trust-based agent framework for networked decision making SO COMPUTATIONAL AND MATHEMATICAL ORGANIZATION THEORY LA English DT Article DE Agent based modeling; Networks; Decision making; Trust ID PERFORMANCE AB Team performance in networked decision making environments has been studied from many different perspectives. However, there are still many unanswered problems when it comes to understanding and quantifying the impact of individual differences of team players, their interpersonal relationships, team connectivity and complex interactions between these factors. In this paper, we present an agent framework that allows the manipulation of all these factors in a principled way. The agents in this framework can be connected through any network structure and can have different characteristics modeled in two dimensions of willingness and competence, which mirror beliefs for each other. Both nodes and links in the network can have differing capacity, modeled by agents' ability to accomplish tasks and their trust for each other. The trust can change as a function of network activity, leading to dynamic scenarios. The framework is implemented as an open source simulation package and is fully extensible. With the help of an information sharing scenario, we conduct a sensitivity analysis and demonstrate the impact of all components of the framework on various network outcomes. In particular, we illustrate that the model provides the ability to study many different trade-offs in team performance and interaction between different parameters. C1 [Adali, Sibel] Rensselaer Polytech Inst, Dept Comp Sci, Troy, NY 12180 USA. [Chan, Kevin; Cho, Jin-Hee] USARL, CISD, Adelphi, MD USA. RP Adali, S (reprint author), Rensselaer Polytech Inst, Dept Comp Sci, 110 8th St Lally 2nd Fl, Troy, NY 12180 USA. EM sibel@cs.rpi.edu; kevin.s.chan@us.army.mil; jinhee.cho@us.army.mil FU Army Research Laboratory [W911NF-09-2-0053]; Department of Defense (DoD) through office of Assistant Secretary of Defense for Research and Engineering (ASD (RE)) FX Research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-09-2-0053. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation here on. This research was also partially supported by the Department of Defense (DoD) through the office of the Assistant Secretary of Defense for Research and Engineering (ASD (R&E)). The views and opinions of the author(s) do not reflect those of the DoD nor ASD (R&E). NR 28 TC 1 Z9 1 U1 5 U2 10 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1381-298X EI 1572-9346 J9 COMPUT MATH ORGAN TH JI Comput. Math. Organ. Theory PD DEC PY 2015 VL 21 IS 4 BP 461 EP 490 DI 10.1007/s10588-015-9193-x PG 30 WC Computer Science, Interdisciplinary Applications; Mathematics, Interdisciplinary Applications; Social Sciences, Mathematical Methods SC Computer Science; Mathematics; Mathematical Methods In Social Sciences GA CV0TT UT WOS:000363967000006 ER PT J AU Kim, C Borodin, O Karniadakis, GE AF Kim, Changho Borodin, Oleg Karniadakis, George Em TI Quantification of sampling uncertainty for molecular dynamics simulation: Time-dependent diffusion coefficient in simple fluids SO JOURNAL OF COMPUTATIONAL PHYSICS LA English DT Article DE Statistical error; Velocity autocorrelation function; Mean-squared displacement; Uncertainty quantification; Gaussian process approximation; Self-diffusion ID STOKES-EINSTEIN LAW; TRANSPORT-COEFFICIENTS; COMPUTER EXPERIMENTS; BOUNDARY-CONDITIONS; BROWNIAN-MOTION; ERROR AB We analyze two standard methods to compute the diffusion coefficient of a tracer particle in a medium from molecular dynamics (MD) simulation, the velocity autocorrelation function (VACF) method, and the mean-squared displacement (MSD) method. We show that they are equivalent in the sense that they provide the same mean values with the same level of statistical errors. We obtain analytic expressions for the level of the statistical errors present in the time-dependent diffusion coefficient as well as the VACF and the MSD. Under the assumption that the velocity of the tracer particle is a Gaussian process, all results are expressed in terms of the VACF. Hence, the standard errors of all relevant quantities are computable once the VACF is obtained from MD simulation. By using analytic models described by the Langevin equations driven by Gaussian white noise and Poissonian white shot noise, we verify our theoretical error estimates and discuss the non-Gaussianity effect in the error estimates when the Gaussian process approximation does not hold exactly. For validation, we perform MD simulations for the self-diffusion of a Lennard-Jones fluid and the diffusion of a large and massive colloid particle suspended in the fluid. Our theoretical framework is also applicable to mesoscopic simulations, e.g., Langevin dynamics and dissipative particle dynamics. (C) 2015 Elsevier Inc. All rights reserved. C1 [Kim, Changho; Karniadakis, George Em] Brown Univ, Div Appl Math, Providence, RI 02912 USA. [Borodin, Oleg] Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA. RP Karniadakis, GE (reprint author), Brown Univ, Div Appl Math, 182 George St, Providence, RI 02912 USA. EM george_karniadakis@brown.edu RI Borodin, Oleg/B-6855-2012 OI Borodin, Oleg/0000-0002-9428-5291 FU U.S. Army Research Laboratory [W911NF-12-2-0023] FX The authors would like to thank Professor Mike Kirby of the University of Utah for discussions. This research was sponsored by the U.S. Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-12-2-0023. NR 38 TC 1 Z9 1 U1 4 U2 22 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0021-9991 EI 1090-2716 J9 J COMPUT PHYS JI J. Comput. Phys. PD DEC 1 PY 2015 VL 302 BP 485 EP 508 DI 10.1016/j.jcp.2015.09.021 PG 24 WC Computer Science, Interdisciplinary Applications; Physics, Mathematical SC Computer Science; Physics GA CV4SF UT WOS:000364256100027 ER PT J AU Zhao, WJ Shan, CS Elias, AL Rajukumar, LP O'Brien, DJ Terrones, M Wei, BQ Suhr, J Lu, XL AF Zhao, Wenjie Shan, Changsheng Elias, Ana L. Rajukumar, Lakshmy P. O'Brien, Daniel J. Terrones, Mauricio Wei, Bingqing Suhr, Jonghwan Lu, X. Lucas TI Hyperelasticity of three-dimensional carbon nanotube sponge controlled by the stiffness of covalent junctions SO CARBON LA English DT Article ID SEMIFLEXIBLE POLYMERS; ELASTICITY; NETWORKS; DIAMETER; MODEL; COMPRESSIBILITY; MECHANICS; COLLAGEN; MODULUS; STRAIN AB To expand the applications of carbon nanotubes (CNTs) at macroscale, a heteroatom doping technique has been employed to fabricate isotropic 3-D CNT architectures by inducing elbow-like covalent junctions into multiwalled CNTs. As the junctions modify the topology of each CNT by favoring the stable bends in CNTs, junction stiffness and the consequence of junction-related morphology changes in sponge's hyperelasticity remain largely elusive. In this study, two types of 3-D multiwalled CNT sponges were fabricated by inducing boron-doped or nitrogen-doped covalent junctions into CNTs. Hyperelastic properties of the sponges were experimentally quantified as the functions of CNT morphology. A novel microstructure informed continuum constitutive law was developed specifically for such isotropic CNT sponges with junctions. Analyzing the experimental data with the new theory demonstrated that, for the first time, the effective modulus of boron-doped junctions (similar to 100 GPa) is higher than that of nitrogen-doped junctions (similar to 20 GPa), and the junction stiffness is a key factor in regulating the hyperelastic compressive modulus of the material. Theoretical analysis further revealed that increased number of junctions and shorter segments on each individual CNT chain would result in stronger hyperelastic 3-D CNT networks. This study has established a fundamental knowledge base to provide guidance for the future design and fabrication of 3-D CNT macrostructures. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Zhao, Wenjie; Wei, Bingqing; Lu, X. Lucas] Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. [Zhao, Wenjie] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. [Shan, Changsheng] Indiana Univ, Dept Chem, Bloomington, IN 47405 USA. [Elias, Ana L.; Terrones, Mauricio] Penn State Univ, Dept Phys, University Pk, PA 16802 USA. [Elias, Ana L.; Terrones, Mauricio] Penn State Univ, Ctr Dimens & Layered Mat 2, University Pk, PA 16802 USA. [Rajukumar, Lakshmy P.; Terrones, Mauricio] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. [O'Brien, Daniel J.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Terrones, Mauricio] Shinshu Univ, Res Ctr Exot Nanocarbons JST, Nagano 3808553, Japan. [Suhr, Jonghwan] Sungkyunkwan Univ, Dept Polymer Sci & Engn, Dept Energy Sci, Suwon 440746, South Korea. RP Lu, XL (reprint author), Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. EM suhr@skku.edu; xlu@udel.edu RI Wei, Bingqing/A-4525-2008 OI Wei, Bingqing/0000-0002-9416-1731 FU U.S. Air Force Office of Scientific Research MURI Grant [FA9550-12-1-0035]; National Research Foundation of Korea [2014R1A2A2A01005496] FX This work was supported by the U.S. Air Force Office of Scientific Research MURI Grant (FA9550-12-1-0035) entitled "Synthesis and Characterization of 3D Carbon Nanotube Solid Networks". J. Suhr also would like to thank the financial support from the National Research Foundation of Korea (2014R1A2A2A01005496). NR 35 TC 0 Z9 0 U1 11 U2 40 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0008-6223 EI 1873-3891 J9 CARBON JI Carbon PD DEC PY 2015 VL 95 BP 640 EP 645 DI 10.1016/j.carbon.2015.08.068 PG 6 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA CU1WM UT WOS:000363312900074 ER PT J AU Zhang, TG Satapathy, SS Vargas-Gonzalez, LR Walsh, SM AF Zhang, Timothy G. Satapathy, Sikhanda S. Vargas-Gonzalez, Lionel R. Walsh, Shawn M. TI Ballistic impact response of Ultra-High-Molecular-Weight Polyethylene (UHMWPE) SO COMPOSITE STRUCTURES LA English DT Article DE Dyneema (R) HB80; BFD; Ballistic limit V-50; Delamination ID DAMAGE PREDICTION; MATERIAL MODEL; COMPOSITES; SIMULATIONS; SHEAR; PERFORMANCE; PLATES AB In this paper we report findings from ballistic experiments conducted on Ultra-High-Molecular-Weight Polyethylene (UHMWPE) flat panels. We measured ballistic limit velocities, V-50 of panels of different thicknesses using a fragment simulating projectile (FSP) and characterized back face deformation (BFD) using a spherical projectile. UHMWPE panels with different architectures (hybrid and non-hybrid) were evaluated. For the back face deformation (BFD) experiments, the thickness of post-impact intact material and interior delamination were characterized using X-ray Computer Tomography method. These measurements were used to evaluate the effects of fiber orientation and boundary constraints on material deformation and failure response to ballistic loading conditions. The expansion rate of the back face deformation zone in the transverse direction (to the direction of impact) decreased with time. This transverse expansion speed was higher in hybrid panels compared to the [0/90] cross-ply panels, which resulted in earlier influence of boundary constraints on back face deformation for hybrid panels. One major delamination occurred in the hybrid panels at cross-ply [0/90] and non-cross ply interface. The lateral extent of this delamination was larger when the panel edges were clamped as compared to the free panel edge case. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Zhang, Timothy G.] TKC Global Inc, Aberdeen Proving Ground, MD 21005 USA. [Satapathy, Sikhanda S.; Vargas-Gonzalez, Lionel R.; Walsh, Shawn M.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Zhang, TG (reprint author), TKC Global Inc, Aberdeen Proving Ground, MD 21005 USA. EM timothy.g.zhang.ctr@mail.mil OI Vargas-Gonzalez, Lionel/0000-0001-6500-1686 FU U.S. Army Research Laboratory [W911QX-14-C-0016] FX The research reported in this document was performed in connection with contract/instrument W911QX-14-C-0016 with the U.S. Army Research Laboratory. The views and conclusions contained in this document are those of TKC Global and the U.S. Army Research Laboratory. Citation of manufacturer's or trade names does not constitute an official endorsement or approval of the use thereof. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon. NR 22 TC 3 Z9 3 U1 11 U2 38 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0263-8223 EI 1879-1085 J9 COMPOS STRUCT JI Compos. Struct. PD DEC 1 PY 2015 VL 133 BP 191 EP 201 DI 10.1016/j.compstruct.2015.06.081 PG 11 WC Materials Science, Composites SC Materials Science GA CT8LW UT WOS:000363069100023 ER PT J AU Gazonas, GA Scheidler, MJ Veto, AP AF Gazonas, G. A. Scheidler, M. J. Veto, A. P. TI Exact analytical solutions for elastodynamic impact SO INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES LA English DT Article DE One-dimensional impact; Elastic wave propagation; Laplace transform; Floor function; Discrete solutions ID WAVE-PROPAGATION; ROD AB We consider the one-dimensional impact problem in which a semi-infinite flyer collides with (and adheres to) the front face of a stationary target plate of finite thickness, with the back face of the target bonded to another semi-infinite medium. All three bodies are assumed to be linear elastic and homogeneous. Our interest is in explicit expressions for the stress and velocity in the target at all times after impact. The analysis of this problem is simplified by reducing it to an initial-boundary value problem for the target only, which is solved by combining the d'Alembert solution of the wave equation with the Laplace transform method. An appropriate impact boundary condition is required on the front face of the target. In the literature this is usually taken as a prescribed step in stress or velocity, but the correct boundary condition involves a linear combination of the unknown stress and velocity at the impact face. Our solutions are expressed in an apparently new, compact form involving the floor (or greatest-integer) function. The results are amenable to asymptotic analysis; in particular, solutions for stress-free or rigid back faces follow easily as limiting cases of the backing impedance, and the long-time asymptotes of stress and velocity in the target are seen to be independent of the target's elastic properties. All of our results are corroborated by derivation of exact discrete solutions from recursive equations for the impact problems. Published by Elsevier Ltd. C1 [Gazonas, G. A.; Scheidler, M. J.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Veto, A. P.] Univ San Diego, Dept Math & Comp Sci, San Diego, CA 92110 USA. RP Gazonas, GA (reprint author), US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM george.a.gazonas.civ@mail.mil NR 45 TC 1 Z9 1 U1 3 U2 12 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0020-7683 EI 1879-2146 J9 INT J SOLIDS STRUCT JI Int. J. Solids Struct. PD DEC PY 2015 VL 75-76 BP 172 EP 187 DI 10.1016/j.ijsolstr.2015.08.011 PG 16 WC Mechanics SC Mechanics GA CT8PZ UT WOS:000363079800014 ER PT J AU Zhang, DY Waas, AM Yen, CF AF Zhang, Dianyun Waas, Anthony M. Yen, Chian-Fong TI Progressive damage and failure response of hybrid 3D textile composites subjected to flexural loading, part I: Experimental studies SO INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES LA English DT Article DE Hybrid 3D textile composite; Flexure; Kink banding; Progressive damage and failure ID FIBER-REINFORCED COMPOSITES; COMPRESSIVE FAILURE; WOVEN COMPOSITES; POLYMER COMPOSITES; TENSILE PROPERTIES; SHEAR RESPONSE; MECHANISMS; MICROMECHANICS; STRENGTH; BEHAVIOR AB This paper presents an experimental investigation of the deformation responses and failure mechanisms of hybrid 3D textile composites (H3DTCs) subjected to quasi-static three-point bending. The term "hybrid" refers to different constituent fiber tows, including carbon, glass, and Kevlar that are integrally woven into a single preform. Three different hybrid architectures, manufactured by varying the percentages and lay-ups of the constituent fiber tows, were examined to understand the effect of hybridization on the resulting performance enhancement, including the bending modulus, flexural yield stress, and strain to failure. All the architectures show a "plastic-like" nonlinear flexural response, indicating considerable damage tolerance and durability for this class of materials. It has been found that increasing the thickness of the specimens can increase the strain to failure in flexure. For an asymmetric H3DTC, which refers to an architecture that has carbon plies on one side and glass plies on the other (through-the-thickness), an increased flexural yield stress can be achieved by placing the glass on the side that experiences compressive straining in flexure, whereas the failure strain is reduced by placing the carbon on the side which experiences tension. Distributed matrix cracking was observed in regions of predominant tension through a digital image correlation (DIC) technique. Although the experimental results show architecture-dependent responses, fiber tow kinking, which develops on the compressive side of the specimen is determined to be a strength limiting mechanism for this class of materials subjected to flexural loading. The experimental results are subsequently used as a basis for developing a mechanics based multiscale computational model for H3DTC deformation, damage and failure response in flexure. Details of the modeling strategy and the development of damage and failure constitutive models are presented in Part II of this two-part sequence (Zhang et al., 2015). (C) 2015 Elsevier Ltd. All rights reserved. C1 [Zhang, Dianyun] Univ Michigan, Dept Aerosp Engn, Ann Arbor, MI 48109 USA. [Zhang, Dianyun; Waas, Anthony M.] Univ Washington, William E Boeing Dept Aeronaut & Astronaut, Seattle, WA 98195 USA. [Yen, Chian-Fong] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Waas, AM (reprint author), Univ Washington, William E Boeing Dept Aeronaut & Astronaut, 211 Guggenheim Hall, Seattle, WA 98195 USA. EM awaas@aa.washington.edu FU Army Research Laboratory, Aberdeen Proving Ground, MD; Army Research Office FX The authors are grateful for the financial support from the Army Research Laboratory, Aberdeen Proving Ground, MD, and the Army Research Office. Dr. Larry Russell was the program monitor. NR 51 TC 6 Z9 6 U1 6 U2 32 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0020-7683 EI 1879-2146 J9 INT J SOLIDS STRUCT JI Int. J. Solids Struct. PD DEC PY 2015 VL 75-76 BP 309 EP 320 DI 10.1016/j.ijsolstr.2015.06.034 PG 12 WC Mechanics SC Mechanics GA CT8PZ UT WOS:000363079800025 ER PT J AU Zhang, DY Waas, AM Yen, CF AF Zhang, Dianyun Waas, Anthony M. Yen, Chian-Fong TI Progressive damage and failure response of hybrid 3D textile composites subjected to flexural loading, part II: Mechanics based multiscale computational modeling of progressive damage and failure SO INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES LA English DT Article DE Hybrid 3D textile composite; Multiscale modeling; Kink banding; Smeared crack approach; Micromechanics; Mesoscale ID WOVEN COMPOSITES; REINFORCED COMPOSITES; COMPRESSIVE FAILURE; FIBER COMPOSITES; IMPACT BEHAVIOR; KINK BANDS; MICROMECHANICS; EVOLUTION; SHEAR; 2D AB A mechanics based multiscale computational model is presented to predict the deformation, damage and failure response of hybrid 3D textile composites (H3DTCs) subjected to three-point bending. The geometry of the textile architecture was incorporated in a mesoscale finite element (FE) model, while the H3DTC was homogenized at the macroscale. The mesoscale model is a collection of repeat unit cells (RUCs) that are composed of different types of fiber tows embedded in a surrounding matrix. Matrix microdamage was modeled by a (pre-peak) nonlinear stress versus strain response, using a modified 12 deformation theory of plasticity incorporating a secant-modulus approach. Fiber tow pre-peak nonlinear response was computed using a novel, two-scale model, in which the subscale micromechanical analysis was carried out in closed-form based upon a unit cell of a fiber-matrix concentric cylinder. Consequently, the influence of matrix microdamage developing at the microscale manifests as the progressive degradation of fiber tow stiffness at the mesoscale. The smeared crack approach (SCA) was employed to model the post-peak softening of the constituents due to failure, including matrix macro-cracking, tow kinking, and tow breaking. This method offers a mesh objective result by relating the post-peak softening response to a traction-separation law that is associated with each failure mechanism through a characteristic length. Thus, the total energy release rate during failure in a continuum element is related to the fracture toughness of the material. The load-deflection responses, along with the progressive damage and failure events, including fiber tow kinking and rupture, are successfully predicted through the proposed computational model. In addition, the textile architecture-dependent effect, observed in the asymmetric H3DTC5, is also captured, demonstrating the predictive capability of the proposed modeling scheme. Since all the inputs are from the constituent level, the model is useful in understanding how the macroscopic response of H3DTC5 is influenced by textile architecture and constituent properties. The experimental studies are presented in Part I of this two-part sequence (Zhang et al., 2015). (C) 2015 Elsevier Ltd. All rights reserved. C1 [Zhang, Dianyun] Univ Michigan, Dept Aerosp Engn, Ann Arbor, MI 48109 USA. [Zhang, Dianyun; Waas, Anthony M.] Univ Washington, William E Boeing Dept Aeronaut & Astronaut, Seattle, WA 98195 USA. [Yen, Chian-Fong] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Waas, AM (reprint author), Univ Washington, William E Boeing Dept Aeronaut & Astronaut, 211 Guggenheim Hall, Seattle, WA 98195 USA. EM awaas@aa.washington.edu FU Army Research Laboratory, Aberdeen Proving Ground, MD; Army Research Office FX The authors are grateful for the financial support from the Army Research Laboratory, Aberdeen Proving Ground, MD, and the Army Research Office. Dr. Larry Russell was the program monitor. NR 57 TC 7 Z9 7 U1 14 U2 44 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0020-7683 EI 1879-2146 J9 INT J SOLIDS STRUCT JI Int. J. Solids Struct. PD DEC PY 2015 VL 75-76 BP 321 EP 335 DI 10.1016/j.ijsolstr.2015.06.033 PG 15 WC Mechanics SC Mechanics GA CT8PZ UT WOS:000363079800026 ER PT J AU Hamilton, JB Best, NC Galbraith, KV Worthy, VC Moore, LTCAD AF Hamilton, Jill B. Best, Nakia C. Galbraith, Kayoll V. Worthy, Valarie C. Moore, L. T. C. Angelo D. TI Strategies African-American Cancer Survivors Use to Overcome Fears and Fatalistic Attitudes SO JOURNAL OF CANCER EDUCATION LA English DT Article DE African-American; Survivorship; Cancer; Fears; Fatalistic attitudes; Social support ID BREAST-CANCER; PROSTATE-CANCER; WOMEN; KNOWLEDGE; SUPPORT; IMPACT; CARE; INTERVENTION; MAMMOGRAPHY; PERCEPTIONS AB This qualitative study explored strategies African-American cancer survivors use to overcome their fears and fatalistic attitudes toward cancer at the point of diagnosis through completion of treatment. Thirty-one African-American cancer survivors who had completed or nearly completed treatment were recruited through criterion purposeful sampling. In-depth, open-ended interviews were used to collect data. The data were analyzed using thematic analysis. Of the 31 survivors interviewed, 26 reported being fearful of cancer and believed that cancer would result in death. These cancer survivors were particularly fearful of having a cancer had spread, of being isolated, and performing less effectively at work. Strategies used to overcome these fears included increasing their own awareness about cancer, using positive self-talk, and avoiding negative people. The findings suggest that past experiences continue to influence fears and fatalistic perspectives about cancer and that educational resources to inform the public about cancer may be ignored until there is a confirmed diagnosis of cancer. Televised news broadcasts of high-profile personalities who had died from cancer were also anxiety provoking, particularly if the cancer survivor died of a recurrence from cancer. Prevalent sources of information and support for these survivors were family members or close friends they trusted with personal information, perceived as strong, or experienced in the care of other cancer survivors. C1 [Hamilton, Jill B.] Johns Hopkins Univ, Sch Nursing, Dept Community Publ Hlth, Baltimore, MD 21205 USA. [Best, Nakia C.; Galbraith, Kayoll V.] Univ N Carolina, Sch Nursing, Chapel Hill, NC 27599 USA. [Worthy, Valarie C.] Sisters Network Inc, Triangle Chapter, Durham, NC 27707 USA. [Moore, L. T. C. Angelo D.] US Army, Womack Army Med Ctr, Ctr Nursing Sci & Clin Inquiry, Ft Bragg, NC USA. RP Hamilton, JB (reprint author), Johns Hopkins Univ, Sch Nursing, Dept Community Publ Hlth, 525 N Wolfe St, Baltimore, MD 21205 USA. EM jhamil32@jh.edu FU Center for Spirituality Theology and Health at Duke University; University of North Carolina Lineberger Comprehensive Cancer Center FX The study in this report was supported with funds from the Center for Spirituality Theology and Health at Duke University (J. Hamilton; Principal Investigator) and the University of North Carolina Lineberger Comprehensive Cancer Center (J. Hamilton, Principal Investigator). NR 29 TC 1 Z9 1 U1 1 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0885-8195 EI 1543-0154 J9 J CANCER EDUC JI J. Cancer Educ. PD DEC PY 2015 VL 30 IS 4 BP 629 EP 635 DI 10.1007/s13187-014-0738-3 PG 7 WC Oncology; Education, Scientific Disciplines; Public, Environmental & Occupational Health SC Oncology; Education & Educational Research; Public, Environmental & Occupational Health GA CT8EP UT WOS:000363048100005 PM 25266472 ER PT J AU Jackson, DD Owens, OL Friedman, DB Dubose-Morris, R AF Jackson, Dawnyea D. Owens, Otis L. Friedman, Daniela B. Dubose-Morris, Ragan TI Innovative and Community-Guided Evaluation and Dissemination of a Prostate Cancer Education Program for African-American Men and Women SO JOURNAL OF CANCER EDUCATION LA English DT Article DE Prostate cancer; African American; Dissemination; Cancer communication; Videoconference; Community-engaged research ID HIGH-RISK POPULATION; HEALTH ADVISERS; DISPARITIES; MORTALITY; SOUTH; PERCEPTIONS; BEHAVIORS; KNOWLEDGE AB African Americans (AA) are more likely to develop and die from cancer than any other racial or ethnic group. The aims of this research were to (1) evaluate current education materials being implemented in a community-based prostate cancer education program for AA communities, (2) refine materials based on findings from aim 1, (3) share updated materials with participants from aim 1 for additional improvements, and (4) disseminate and evaluate the improved education program through a statewide videoconference with AA men and women. AA individuals evaluated the current education program through a mail survey (n = 32) and community forum (n = 38). Participants reported that the existing prostate cancer education program content could be understood by lay persons, but recommendations for improvement were identified. They included the following: defining unknown and/or scientific terminology, increasing readability by increasing font size and enlarging images, and including more recent and relevant statistics. Following refinement of the education materials based on survey and forum feedback, a statewide videoconference was implemented. Following the videoconference, participants (25 men; 3 women) reported that they would encourage others to learn more about prostate cancer, talk to their doctor about whether or not to get screened for prostate cancer, and recommend the conference to others. There is great potential for using this type of iterative approach to education program development with community and clinical partners for others conducting similar work. C1 [Jackson, Dawnyea D.] Army Inst Publ Hlth, US Army Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. [Owens, Otis L.] Univ S Carolina, Coll Social Work, Columbia, SC 29208 USA. [Friedman, Daniela B.] Univ S Carolina, Dept Hlth Promot Educ & Behav, Columbia, SC 29208 USA. [Friedman, Daniela B.] Univ S Carolina, Statewide Canc Prevent & Control Program, Columbia, SC 29208 USA. [Dubose-Morris, Ragan] Med Univ S Carolina, South Carolina Area Hlth Educ Consortium, Charleston, SC 29425 USA. [Dubose-Morris, Ragan] Med Univ S Carolina, Dept Lib Sci & Informat, Charleston, SC 29425 USA. [Friedman, Daniela B.] Univ S Carolina, Arnold Sch Publ Hlth, Canc Prevent & Control Program, Columbia, SC 29208 USA. RP Friedman, DB (reprint author), Univ S Carolina, Arnold Sch Publ Hlth, Canc Prevent & Control Program, 915 Greene St,Suite 235, Columbia, SC 29208 USA. EM dbfriedman@sc.edu FU National Cancer Institute (NCI) Community Networks Program Centers [U54/CA153461]; South Carolina Cancer Alliance; South Carolina Cancer Prevention and Control Research Network from the Centers for Disease Control and Prevention (Prevention Research Centers) [U48DP001936]; National Cancer Institute FX This study was funded partially by the National Cancer Institute (NCI) Community Networks Program Centers U54/CA153461 and an implementation grant from the South Carolina Cancer Alliance. Friedman also partially supported by the South Carolina Cancer Prevention and Control Research Network under Cooperative Agreement Number U48DP001936 from the Centers for Disease Control and Prevention (Prevention Research Centers) and the National Cancer Institute. We are most grateful to our prostate cancer videoconference partners: Johnny Payne, Rev. Tony Minter, Edna Williams, Kelvin Williams, Alicia McMenamin, and Kim M. Johnson. NR 28 TC 0 Z9 0 U1 3 U2 8 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0885-8195 EI 1543-0154 J9 J CANCER EDUC JI J. Cancer Educ. PD DEC PY 2015 VL 30 IS 4 BP 779 EP 785 DI 10.1007/s13187-014-0774-z PG 7 WC Oncology; Education, Scientific Disciplines; Public, Environmental & Occupational Health SC Oncology; Education & Educational Research; Public, Environmental & Occupational Health GA CT8EP UT WOS:000363048100028 PM 25510370 ER PT J AU Golius, A Gorb, L Scott, AM Hill, FC Felt, D Larson, S Ballard, J Leszczynski, J AF Golius, Anastasiia Gorb, Leonid Scott, Andrea Michalkova Hill, Frances C. Felt, Deborah Larson, Steven Ballard, John Leszczynski, Jerzy TI Computational study of nitroguanidine (NQ) tautomeric properties in aqueous solution SO STRUCTURAL CHEMISTRY LA English DT Article DE Nitroguanidine; Energetic materials; Acidity; Computational; Tautomers ID CRYSTAL-STRUCTURE; SOLVATION; SPECTRA; MODEL; 2-NITROGUANIDINE; PREDICTION; REFINEMENT; MOLECULES; FORMS AB This study focused on investigation of the tautomeric properties of nitroguanidine (NQ), an energetic material, using theoretical approaches for NQ in both the gas phase and in aqueous solution. Density functional method (M062X) was used to estimate physical and chemical properties of NQ tautomers. Two different solvent models (CPCM and PCM) and two basis sets (6-31G(d,p) and 6-31 + G(d,p)) were utilized. A ranking of the stability order of the tautomers was predicted based on changes in Gibbs free energy values and were generally found to be in good agreement with previous theoretical and experimental studies. Electronic properties including dipole moment, electron affinity, ionization potential and charges of NQ were predicted in both gas and aqueous phases. In order to analyze NQ behavior in aqueous solution, several properties were calculated. Deprotonating as well as protonating of NQ revealed positive energies indicating that those processes are rather unfavorable and further characterized NQ as a compound with weak acid-base properties. We have calculated pK(a) and pK(b) values using data obtained from quantum chemical calculations using CPCM and COSMO-RS approaches. The COSMO-RS approach was able to reproduce experimental values with high accuracy, while the results obtained with CPCM method significantly differ from values obtained experimentally. C1 [Golius, Anastasiia; Leszczynski, Jerzy] Jackson State Univ, Dept Chem & Biochem, Jackson, MS 39217 USA. [Gorb, Leonid] HX5 LLC, Vicksburg, MS USA. [Scott, Andrea Michalkova; Hill, Frances C.; Felt, Deborah; Larson, Steven; Ballard, John] US Army Engineer Res & Dev Ctr, Vicksburg, MS USA. RP Leszczynski, J (reprint author), Jackson State Univ, Dept Chem & Biochem, Jackson, MS 39217 USA. EM jerzy@icnanotox.org FU Environmental Quality Technology Program of the United States Army Corps of Engineers by the US Army ERDC FX This work was facilitated by support from the High Performance Computing Distributed Shared Resource Center (DSRC) at the ERDC (Vicksburg, MS). The use of trade, product, or firm names in this report is for descriptive purposes only and does not imply endorsement by the U.S. Government. Results in this study were funded and obtained from research conducted under the Environmental Quality Technology Program of the United States Army Corps of Engineers by the US Army ERDC. Permission was granted by the Chief of Engineers to publish this information. The findings of this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents. NR 38 TC 0 Z9 0 U1 2 U2 18 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1040-0400 EI 1572-9001 J9 STRUCT CHEM JI Struct. Chem. PD DEC PY 2015 VL 26 IS 5-6 SI SI BP 1273 EP 1280 DI 10.1007/s11224-015-0684-7 PG 8 WC Chemistry, Multidisciplinary; Chemistry, Physical; Crystallography SC Chemistry; Crystallography GA CT7BH UT WOS:000362967600009 ER PT J AU Golius, A Gorb, L Scott, AM Hill, FC Leszczynski, J AF Golius, Anastasiia Gorb, Leonid Scott, Andrea Michalkova Hill, Frances C. Leszczynski, Jerzy TI Computational study of NTO (5-nitro-2,4-dihydro-3H-1,2,4-triazol-3-one) tautomeric properties in aqueous solution SO STRUCTURAL CHEMISTRY LA English DT Article DE Nitrocompounds; Energetic materials; Acidity; Computational; Tautomers ID ENERGETIC MATERIALS; SOLVATION; MODEL; MOLECULES AB This study focuses on elucidating the stable forms of a new energetic material that is a member of the class of insensitive munitions (IM), 5-nitro-2,4-dihydro-3H-1,2,4-triazol-3-one (NTO), including its tautomers, and anions. The geometry and properties of all compounds were calculated using density functional theory (M06-2X) and MP2 quantum chemical approaches. Calculations were carried out in the gas phase and in aqueous solution. Chemical stability of these compounds was evaluated in terms of the Gibbs free energy change. Two different solvation models were applied (CPCM and PCM). Calculations showed that overall differences in the results obtained using these two solvation models are negligible for all compounds considered. All possible NTO tautomers were examined and the results are in good agreement with previous studies performed in the gas phase. The stability order was revealed to be slightly dependent on the method applied. In order to estimate acidic properties of NTO, anions of several NTO tautomers were analyzed. In addition, pK (a) values were calculated using different approaches. As compared with available experimental data it was found that the conductor-like screening model for real solvents approach leads to more accurate estimation of the pK (a) value than the CPCM and PCM approaches. The pK (a) value calculated using PCM and CPCM data showed large errors; however, it was proven that the pattern of deprotonation energy was correctly estimated. C1 [Golius, Anastasiia; Leszczynski, Jerzy] Jackson State Univ, Dept Chem & Biochem, Jackson, MS 39217 USA. [Gorb, Leonid] Badger Tech Serv LLC, Vicksburg, MS 39180 USA. [Scott, Andrea Michalkova; Hill, Frances C.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Leszczynski, J (reprint author), Jackson State Univ, Dept Chem & Biochem, 1400 JR Lynch St, Jackson, MS 39217 USA. EM anastasia@icnanotox.org; jerzy@icnanotox.org FU Environmental Quality Technology Program of the United States Army Corps of Engineers by the US Army ERDC FX This work was facilitated by support from the High Performance Computing Distributed Shared Resource Center (DSRC) at the ERDC (Vicksburg, MS). The use of trade, product, or firm names in this report is for descriptive purposes only and does not imply endorsement by the U.S. Government. Results in this study were funded and obtained from research conducted under the Environmental Quality Technology Program of the United States Army Corps of Engineers by the US Army ERDC. Permission was granted by the Chief of Engineers to publish this information. The findings of this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents. NR 30 TC 2 Z9 2 U1 5 U2 20 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1040-0400 EI 1572-9001 J9 STRUCT CHEM JI Struct. Chem. PD DEC PY 2015 VL 26 IS 5-6 SI SI BP 1281 EP 1286 DI 10.1007/s11224-014-0526-z PG 6 WC Chemistry, Multidisciplinary; Chemistry, Physical; Crystallography SC Chemistry; Crystallography GA CT7BH UT WOS:000362967600010 ER PT J AU Gill, HS Thota, S Li, L Ren, HZ Mosurkal, R Kumar, J AF Gill, Hardeep Singh Thota, Sammaiah Li, Lian Ren, Haizhou Mosurkal, Ravi Kumar, Jayant TI Reusable SERS active substrates for ultrasensitive molecular detection SO SENSORS AND ACTUATORS B-CHEMICAL LA English DT Article DE SERS; Femtosecond; Nanostructures; Detectors ID ENHANCED RAMAN-SCATTERING; FEMTOSECOND LASER; NANOSTRUCTURES; SPECTROSCOPY; GOLD AB Silver nanoparticles coated silicon nanospikes were investigated as efficient and reusable SERS active substrates. Silicon nanospikes were fabricated employing femtosecond laser pulses and were made SERS active through deposition of silver nanoparticles by reducing silver nitrate. The prepared substrates offer good SERS reproducibility with high enhancement factors. The SERS detection limits of 1 pico-molar from Rhodamine 6G and 100 pico-molar from Methylene blue were demonstrated. In addition, these SERS substrates are reusable by simple washing and no observable degradation of sensitivity was measured. (C) 2015 Elsevier B.V. All rights reserved. C1 [Gill, Hardeep Singh; Thota, Sammaiah; Kumar, Jayant] Univ Massachusetts, Ctr Adv Mat, Lowell, MA 01854 USA. [Gill, Hardeep Singh; Ren, Haizhou] Univ Massachusetts, Dept Phys & Appl Phys, Lowell, MA 01854 USA. [Li, Lian; Mosurkal, Ravi] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. RP Kumar, J (reprint author), Univ Massachusetts, Ctr Adv Mat, Lowell, MA 01854 USA. EM Hardeep_Gill@student.uml.edu; Mosurkal.civ@mail.mil; Jayant_Kumar@uml.edu RI MOSURKAL, RAVI/P-6981-2015 FU Polymer-Based Materials for Harvesting Solar Energy, an Energy Frontier Research Center - U.S. Department of Energy Office of Science, Basic Energy Sciences [DE-SC0001087]; U.S. Army Natick Soldier Research, Development and Engineering Center (NSRDEC) FX This work was partially supported by the Polymer-Based Materials for Harvesting Solar Energy, an Energy Frontier Research Center funded by the U.S. Department of Energy Office of Science, Basic Energy Sciences (Award #DE-SC0001087). This research was also supported by in part by an appointment to the Faculty Research Participation Program at the U.S. Army Natick Soldier Research, Development and Engineering Center (NSRDEC) administered by the Oak Ridge Institute for Science and Education through an inter-agency agreement between the U.S. Department of Energy and NSRDEC. NR 20 TC 4 Z9 4 U1 7 U2 88 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0925-4005 J9 SENSOR ACTUAT B-CHEM JI Sens. Actuator B-Chem. PD DEC 1 PY 2015 VL 220 BP 794 EP 798 DI 10.1016/j.snb.2015.05.114 PG 5 WC Chemistry, Analytical; Electrochemistry; Instruments & Instrumentation SC Chemistry; Electrochemistry; Instruments & Instrumentation GA CR3QX UT WOS:000361249100105 ER PT J AU Goodson, LP AF Goodson, Larry P. TI Vying for Allah's Vote: Understanding Islamic Parties, Political Violence, and Extremism in Pakistan SO MIDDLE EAST JOURNAL LA English DT Book Review C1 [Goodson, Larry P.] US Army, War Coll, Gen Dwight D Eisenhower Chair Natl Secur, Carlisle, PA USA. RP Goodson, LP (reprint author), US Army, War Coll, Gen Dwight D Eisenhower Chair Natl Secur, Carlisle, PA USA. NR 1 TC 0 Z9 0 U1 3 U2 11 PU MIDDLE EAST INST PI WASHINGTON PA 1761 N ST NW, CIRCULATION DEPT, WASHINGTON, DC 20036-2882 USA SN 0026-3141 EI 1940-3461 J9 MIDDLE EAST J JI Middle East J. PD WIN PY 2015 VL 69 IS 1 BP 135 EP 137 PG 3 WC Area Studies SC Area Studies GA CA0RD UT WOS:000348623400008 ER PT J AU Goodson, LP AF Goodson, Larry P. TI The Pashtun Question: The Unresolved Key to the Future of Pakistan and Afghanistan SO MIDDLE EAST JOURNAL LA English DT Book Review C1 [Goodson, Larry P.] US Army, War Coll, Gen Dwight D Eisenhower Chair Natl Secur, Carlisle, PA USA. RP Goodson, LP (reprint author), US Army, War Coll, Gen Dwight D Eisenhower Chair Natl Secur, Carlisle, PA USA. NR 1 TC 0 Z9 0 U1 1 U2 9 PU MIDDLE EAST INST PI WASHINGTON PA 1761 N ST NW, CIRCULATION DEPT, WASHINGTON, DC 20036-2882 USA SN 0026-3141 EI 1940-3461 J9 MIDDLE EAST J JI Middle East J. PD WIN PY 2015 VL 69 IS 1 BP 135 EP 137 PG 3 WC Area Studies SC Area Studies GA CA0RD UT WOS:000348623400007 ER PT J AU Harper, DA AF Harper, David A. TI Revising Obsession in Shakespeare's Sonnets 153 and 154 SO STUDIES IN PHILOLOGY LA English DT Article AB This article reevaluates Shakespeare's sonnets 153 and 154 within the context of the 1609 Quarto, suggesting that only one of these anacreontics properly belongs to the sequence. The article first considers other moments of unintentional repetition in Shakespeare's corpus to provide evidence that Shakespeare's manuscript cancellations may have been overlooked by printers. Using 1) the bibliographic features of the Quarto, 2) Sonnet 153's thematic and formal linkages to the preceding sequence, and 3) the aptness of 153 rather than 154 as a bridge to A Lover's Complaint, the article argues that Shakespeare's likely cancellation of 154 was ignored in Eld's print shop for convenience or aesthetic concerns. While we may never know what shape Shakespeare's Sonnets took in manuscript, this article reclaims 153 as an important conclusion to the sequence, challenging a tradition of criticism in which the curious doubling of these two sonnets has often removed them from serious consideration. C1 US Mil Acad, West Point, NY USA. RP Harper, DA (reprint author), US Mil Acad, West Point, NY USA. RI Savarala, Hari Krishna/A-3516-2015 OI Savarala, Hari Krishna/0000-0001-6593-4849 NR 28 TC 0 Z9 0 U1 0 U2 13 PU UNIV NORTH CAROLINA PRESS PI CHAPEL HILL PA BOX 2288, JOURNALS DEPT, CHAPEL HILL, NC 27515-2288 USA SN 0039-3738 EI 1543-0383 J9 STUD PHILOL JI Stud. Philol. PD WIN PY 2015 VL 112 IS 1 BP 114 EP 138 PG 25 WC Language & Linguistics; Literature SC Linguistics; Literature GA CA0TP UT WOS:000348629600006 ER PT J AU Strenge, KS Kunkel, JE George, AA Mailhiot, T Butler, SL AF Strenge, Karen S. Kunkel, Julie E. George, Alan A. Mailhiot, Thomas Butler, Samantha L. TI Utility of Reflexive Gomori Methenamine Silver and Acid-Fast Bacillus Staining on Bronchoalveolar Lavage Specimens SO LABMEDICINE LA English DT Article DE reflexive; testing; bronchoalveolar; lavage; AFB; GMS AB Objective: Reflexive testing of bronchoalveolar lavage (BAL) specimens with Gomori methenamine silver (GMS) and acid-fast bacillus (AFB) stains is not routinely performed by most institutions. Instead, these stains are usually ordered to evaluate for the presence of fungal elements and/or acid-fast organisms if initial histopathologic assessment suggests the presence of these pathogens. Our institution, however, performs these stains on all BAL specimens. Thus, we sought to determine whether this practice was cost effective, considering the turnaround time and diagnostic efficacy of these tests. Methods: We retrospectively reviewed-488 BAL specimens performed at two military healthcare institutions over a 2-year period and performed a cost analysis with review of the impact on turnaround time. Results: Of the 488 cases, we identified only 3 (similar to 0.6%) with infections by. acid-fast or fungal organisms, at an estimated total cost of $12,151.20 and an average delay of 3.0 to 3.5 hours for slide preparation. Conclusion: Our results suggest that in a largely young and healthy population such as ours, it may be more feasible to perform these stains on BAL specimens on a case-by-case basis rather than automatically on-every specimen, to control costs and enhance productivity. C1 [Strenge, Karen S.; Kunkel, Julie E.; George, Alan A.; Mailhiot, Thomas; Butler, Samantha L.] Brooke Army Med Ctr, Pathol & Area Lab Serv, San Antonio, TX 78234 USA. RP Butler, SL (reprint author), Brooke Army Med Ctr, Pathol & Area Lab Serv, San Antonio, TX 78234 USA. EM samantha.l.butler.mil@mail.mil NR 9 TC 0 Z9 0 U1 1 U2 19 PU AMER SOC CLINICAL PATHOLOGY PI CHICAGO PA 2100 W HARRISON ST, CHICAGO, IL 60612 USA SN 0007-5027 EI 1943-7730 J9 LABMEDICINE JI Labmedicine PD WIN PY 2015 VL 46 IS 1 BP 4 EP 7 DI 10.1309/LMLJHG4E2UZKD7RG PG 4 WC Medical Laboratory Technology SC Medical Laboratory Technology GA AZ5GJ UT WOS:000348248000001 PM 25617385 ER PT J AU Dunbar, ZW AF Dunbar, Zachary W. TI Hydrogen purification of synthetic water gas shift gases using microstructured palladium membranes SO JOURNAL OF POWER SOURCES LA English DT Article DE Palladium membrane; Fuel processing; Hydrogen purification; Separation; Reforming ID COMPOSITE MEMBRANES; STORAGE MATERIALS; ALLOY MEMBRANES; CARBON-MONOXIDE; FUEL; DIFFUSION; STEAM; SEPARATION; PD; TEMPERATURES AB Novel microstructured palladium composite membranes are fabricated using microfabrication technologies. The membranes have a thickness of 1 micron, and are supported by a microstructured nickel lattice 10 micron in thickness. The membranes' flux versus hydrogen partial pressure are evaluated, and a linear correlation found, indicating a deviation from Sieverts Law due to their relative thinness. The permeance of the membrane are found to be approximately 3 x 10(-6) mol*m(-2)*s(-1)*Pa-1. The membranes are tested under Department of Energy specified synthetic water gas shift mixtures at temperatures of 320 degrees C and 380 degrees C and exhibited fluxes between 0.2 and 0.4 mol*m(-2)*s at 275 kPa(g) (40 psig). The membranes have stable performance at 320 degrees C, while alloying of the palladium and nickel support slowly occurs at 380 degrees C, causing a decline in flux. A permeance selectivity of 458:1 H-2:He is observed at a pressure gradient of 1.37 MPag (205 psig) and 380 degrees C, however a true 'burst pressure' is unable to be determined due to the maximum output limitations of the pressure regulator. Hydrogen sulfide reduces membrane performance, as expected of a pure palladium membrane. (C) 2015 Elsevier B.V. All rights reserved. C1 Army Res Lab, Adelphi, MD 20783 USA. RP Dunbar, ZW (reprint author), Army Res Lab, Adelphi, MD 20783 USA. EM Zachary.dunbar.ctr@mail.mil NR 53 TC 1 Z9 1 U1 3 U2 30 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 EI 1873-2755 J9 J POWER SOURCES JI J. Power Sources PD NOV 30 PY 2015 VL 297 BP 525 EP 533 DI 10.1016/j.jpowsour.2015.08.015 PG 9 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA CS0SN UT WOS:000361772600064 ER PT J AU Fiedler, JW Brodie, KL McNinch, JE Guza, RT AF Fiedler, Julia W. Brodie, Katherine L. McNinch, Jesse E. Guza, Robert T. TI Observations of runup and energy flux on a low-slope beach with high-energy, long-period ocean swell SO GEOPHYSICAL RESEARCH LETTERS LA English DT Article ID INFRAGRAVITY WAVES; SWASH OSCILLATIONS; DISSIPATION; NEARSHORE; INTERMEDIATE; VARIABILITY; SURFZONE; CLIMATE; MOTIONS; SETUP AB The transformation of surface gravity waves from 11 m depth to runup was observed on the low-sloped (1/80) Agate Beach, Oregon, with a cross-shore transect of current meters, pressure sensors, and a scanning lidar. Offshore wave heights H-0 ranged from calm (0.5 m) to energetic (> 7 m). Runup, measured with pressure sensors and a scanning lidar, increases linearly with (H0L0)(1/2), with L-0 the deep-water wavelength of the spectral peak. Runup saturation, in which runup oscillations plateau despite further increases in (H0L0)(1/2), is not observed. Infragravity wave shoaling and nonlinear energy exchanges with short waves are included in an infragravity wave energy balance. This balance closes for high-infragravity frequencies (0.025-0.04 Hz) but not lower frequencies (0.003-0.025 Hz), possibly owing to unmodeled infragravity energy losses of wave breaking and/or bottom friction. Dissipative processes limit, but do not entirely damp, increases in runup excursions in response to increased incident wave forcing. C1 [Fiedler, Julia W.; Guza, Robert T.] Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 USA. [Brodie, Katherine L.; McNinch, Jesse E.] US Army Engn Res & Dev Ctr, Coastal & Hydraul Lab, Duck, NC USA. RP Fiedler, JW (reprint author), Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 USA. EM jfiedler@ucsd.edu FU California Department of Parks and Recreation, Division of Boating and Waterways Oceanography Program; United States Army Corps of Engineers Coastal Ocean Data Systems Program (CODS); Department of Defense (DoD) through the National Defense Science and Engineering Graduate Fellowship (NDSEG) Program FX This study was partially funded by the California Department of Parks and Recreation, Division of Boating and Waterways Oceanography Program, and the United States Army Corps of Engineers Coastal Ocean Data Systems Program (CODS). J.F. was supported by the Department of Defense (DoD) through the National Defense Science and Engineering Graduate Fellowship (NDSEG) Program. Fieldwork was accomplished by Brian Woodward, Bill Boyd, Kent Smith, Dennis Darnell, Rob Grenzeback, and Nick Spore, with assistance from Bonnie Ludka and Timu Gallien. Jeff and Liz Olsen provided critical support for lidar observations. Michele Okihiro organized logistics. Offshore wave data were obtained from NDBC Buoy 46050 (http://www.ndbc.noaa.gov/). This work comprises a portion of J. Fiedler's PhD thesis. As subsequent thesis chapters will use these same data, they are not shared with this work. However, upon completion of Fiedler's thesis, data will be made available in accordance with the AGU data policy. The authors thank two anonymous reviewers for their helpful suggestions. NR 28 TC 1 Z9 1 U1 2 U2 4 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0094-8276 EI 1944-8007 J9 GEOPHYS RES LETT JI Geophys. Res. Lett. PD NOV 28 PY 2015 VL 42 IS 22 BP 9933 EP 9941 DI 10.1002/2015GL066124 PG 9 WC Geosciences, Multidisciplinary SC Geology GA DB2MO UT WOS:000368343200041 ER PT J AU Excler, JL Robb, ML Kim, JH AF Excler, Jean-Louis Robb, Merlin L. Kim, Jerome H. TI Prospects for a globally effective HIV-1 vaccine SO VACCINE LA English DT Review DE HIV-1; Vaccine; Correlates; Clinical trial; Efficacy; Public health; Licensure ID HUMAN-IMMUNODEFICIENCY-VIRUS; BROADLY NEUTRALIZING ANTIBODIES; RECOMBINANT GLYCOPROTEIN-120 VACCINE; T-CELL VACCINE; CONTROLLED PHASE-3 TRIAL; HIGHLY PATHOGENIC SIV; RHESUS-MONKEYS; EFFICACY TRIAL; IMMUNE-RESPONSES; DOUBLE-BLIND AB A globally effective vaccine strategy must cope with the broad genetic diversity of HIV and contend with multiple transmission modalities. Understanding correlates of protection and the role of diversity in limiting protective vaccines with those correlates is key. RV144 was the first HIV-1 vaccine trial to demonstrate efficacy against HIV-1 infection. A correlates analysis compared vaccine-induced immune responses in vaccinated-infected and vaccinated-uninfected volunteers suggested that IgG specific for the V1V2 region of gp120 was associated with reduced risk of HIV-1 infection and that plasma Env IgA was directly correlated with infection risk. RV144 and recent NHP challenge studies suggest that Env is essential and perhaps sufficient to induce protective antibody responses against mucosally acquired HIV-1. Whether RV144 immune correlates can apply to different HIV vaccines, to populations with different modes and intensity of transmission, or to divergent HIV-1 subtypes remains unknown. Newer prime-boost mosaic and conserved sequence immunization strategies aiming at inducing immune responses of greater breadth and depth as well as the development of immunogens inducing broadly neutralizing antibodies should be actively pursued. Efficacy trials are now planned in heterosexual populations in southern Africa and MSM in Thailand. Although NHP challenge studies may guide vaccine development, human efficacy trials remain key to answer the critical questions leading to the development of a global HIV-1 vaccine for licensure. (C) 2015 by American Journal of Preventive Medicine and Elsevier Ltd. All rights reserved. C1 [Excler, Jean-Louis; Robb, Merlin L.; Kim, Jerome H.] US Mil HIV Res Program MHRP, Walter Reed Army Inst Res, Bethesda, MD 20817 USA. [Excler, Jean-Louis; Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. RP Excler, JL (reprint author), US Mil HIV Res Program MHRP, 6720-A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA. EM jexcler@hivresearch.org FU U.S. Army Medical Research and Materiel Command (USAMRMC) [Y1-AI-2642-12]; National Institutes of Allergy and Infectious Diseases [Y1-AI-2642-12]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DOD) [W81XWH-07-2-0067] FX The preparation of this manuscript was supported in part by an Interagency Agreement Y1-AI-2642-12 between U.S. Army Medical Research and Materiel Command (USAMRMC) and the National Institutes of Allergy and Infectious Diseases. In addition, this work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD). NR 154 TC 10 Z9 10 U1 4 U2 14 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD NOV 27 PY 2015 VL 33 SU 4 BP D4 EP D12 DI 10.1016/j.vaccine.2015.03.059 PG 9 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA CZ0BN UT WOS:000366770200002 PM 26100921 ER PT J AU Thomas, SJ Rothman, AL AF Thomas, Stephen J. Rothman, Alan L. TI Trials and tribulations on the path to developing a dengue vaccine SO VACCINE LA English DT Review DE Dengue; Vaccine; Immunology ID HUMAN INFECTION MODEL; CLINICAL LABORATORY RESPONSES; NEUTRALIZING ANTIBODY-LEVELS; HEALTHY ADULT VOLUNTEERS; FLAVIVIRUS-NAIVE ADULTS; PRIMARY-SCHOOL CHILDREN; VIRUS-INFECTION; NONHUMAN-PRIMATES; HUMAN CHALLENGE; JAPANESE ENCEPHALITIS AB Dengue is a rapidly expanding global health problem. Development of a safe and efficacious tetravalent vaccine along with strategic application of vector control activities represents a promising approach to reducing the global disease burden. Although many vaccine development challenges exist, numerous candidates are in clinical development and one has been tested in three clinical endpoint studies. The results of these studies have raised numerous questions about how we measure vaccine immunogenicity and how these readouts are associated with clinical outcomes in vaccine recipients who experience natural infection. In this review the authors discuss the dengue vaccine pipeline, development challenges, the dengue vaccine-immunologic profiling intersection, and research gaps. (C) 2015 by American Journal of Preventive Medicine and Elsevier Ltd. All rights reserved. C1 [Thomas, Stephen J.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Rothman, Alan L.] Univ Rhode Isl, Providence, RI 02908 USA. RP Thomas, SJ (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. EM stephen.j.thomas3.mil@mail.mil OI Rothman, Alan/0000-0002-4064-6848 FU Merck; Novartis FX This article is being published concurrently in the American Journal of Preventive Medicine and Vaccine. The articles are identical except for stylistic changes in keeping with each journal's style. Either of these versions may be used in citing this article. Publication of this article was supported by Merck and Novartis. NR 135 TC 10 Z9 12 U1 3 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD NOV 27 PY 2015 VL 33 SU 4 BP D24 EP D31 DI 10.1016/j.vaccine.2015.05.095 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA CZ0BN UT WOS:000366770200004 PM 26122583 ER PT J AU Amani, M Lien, DH Kiriya, D Xiao, J Azcatl, A Noh, J Madhvapathy, SR Addou, R Santosh, KC Dubey, M Cho, K Wallace, RM Lee, SC He, JH Ager, JW Zhang, X Yablonovitch, E Javey, A AF Amani, Matin Lien, Der-Hsien Kiriya, Daisuke Xiao, Jun Azcatl, Angelica Noh, Jiyoung Madhvapathy, Surabhi R. Addou, Rafik Santosh, K. C. Dubey, Madan Cho, Kyeongjae Wallace, Robert M. Lee, Si-Chen He, Jr-Hau Ager, Joel W., III Zhang, Xiang Yablonovitch, Eli Javey, Ali TI Near-unity photoluminescence quantum yield in MoS2 SO SCIENCE LA English DT Article ID MONOLAYER MOS2; NATURAL MOS2; LAYER MOS2; HETEROSTRUCTURES; SEMICONDUCTORS; TRANSITION; DYNAMICS; DEFECTS; BANDGAP; STRAIN AB Two-dimensional (2D) transition metal dichalcogenides have emerged as a promising material system for optoelectronic applications, but their primary figure of merit, the room-temperature photoluminescence quantum yield (QY), is extremely low. The prototypical 2D material molybdenum disulfide (MoS2) is reported to have a maximum QY of 0.6%, which indicates a considerable defect density. Herewe report on an air-stable, solution-based chemical treatment by an organic superacid, which uniformly enhances the photoluminescence and minority carrier lifetime of MoS2 monolayers by more than two orders of magnitude. The treatment eliminates defect-mediated nonradiative recombination, thus resulting in a final QY of more than 95%, with a longest-observed lifetime of 10.8 0.6 nanoseconds. Our ability to obtain optoelectronic monolayers with near-perfect properties opens the door for the development of highly efficient light-emitting diodes, lasers, and solar cells based on 2D materials. C1 [Amani, Matin; Lien, Der-Hsien; Kiriya, Daisuke; Madhvapathy, Surabhi R.; Yablonovitch, Eli; Javey, Ali] Univ Calif Berkeley, Elect Engn & Comp Sci, Berkeley, CA 94720 USA. [Amani, Matin; Lien, Der-Hsien; Kiriya, Daisuke; Xiao, Jun; Madhvapathy, Surabhi R.; Ager, Joel W., III; Zhang, Xiang; Yablonovitch, Eli; Javey, Ali] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA. [Lien, Der-Hsien; He, Jr-Hau] King Abdullah Univ Sci & Technol, Comp Elect & Math Sci & Engn Div, Thuwal 239556900, Saudi Arabia. [Lien, Der-Hsien; Lee, Si-Chen] Natl Taiwan Univ, Inst Elect Engn, Dept Elect Engn, Taipei 10617, Taiwan. [Xiao, Jun; Zhang, Xiang] Univ Calif Berkeley, Natl Sci Fdn Nanoscale Sci & Engn Ctr, Berkeley, CA 94720 USA. [Azcatl, Angelica; Noh, Jiyoung; Addou, Rafik; Santosh, K. C.; Cho, Kyeongjae; Wallace, Robert M.] Univ Texas Dallas, Dept Mat Sci & Engn, Richardson, TX 75080 USA. [Dubey, Madan] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20723 USA. [Zhang, Xiang] King Abdulaziz Univ, Dept Phys, Jeddah 21589, Saudi Arabia. RP Javey, A (reprint author), Univ Calif Berkeley, Elect Engn & Comp Sci, Berkeley, CA 94720 USA. EM ajavey@eecs.berkeley.edu RI Javey, Ali/B-4818-2013; Zhang, Xiang/F-6905-2011; Addou, Rafik/C-8992-2013; Wallace, Robert/A-5283-2008; OI Addou, Rafik/0000-0002-5454-0315; Wallace, Robert/0000-0001-5566-4806; KC, Dr. Santosh/0000-0003-4650-3722 FU Office of Science, Office of Basic Energy Sciences, Materials Sciences and Engineering Division of the U.S. Department of Energy [DE-AC02-05Ch11231]; Center for Low Energy System Technology (LEAST), one of six centers - STARnet phase of the Focus Research Program (FCRP), a Semiconductor Research Corporation program - Microelectronics Advanced Research Corporation; Defense Advanced Research Projects Agency; Samsung; NSF Center for Energy Efficient Electronics Science (E3S); KAUST; U.S. Army Research Lab Director's Strategic Initiative program on interfaces in stacked 2D atomic layers and materials FX We thank F. R. Fischer for in-depth discussions on surface chemistry and A. B. Sachid for analysis of the electrical measurements. M.A., J.X., J.W.A., X.Z., and A.J. were funded by the Director, Office of Science, Office of Basic Energy Sciences, Materials Sciences and Engineering Division of the U.S. Department of Energy, under contract no. DE-AC02-05Ch11231. A. A., J.N., R. A., S.KC, R.M.W., and K.C. were funded by the Center for Low Energy System Technology (LEAST), one of six centers supported by the STARnet phase of the Focus Research Program (FCRP), a Semiconductor Research Corporation program sponsored by Microelectronics Advanced Research Corporation and Defense Advanced Research Projects Agency. D.K. acknowledges support from Samsung, E.Y. acknowledges support from the NSF Center for Energy Efficient Electronics Science (E3S), J.-H.H. acknowledges support from the baseline fund of KAUST, and M.D. acknowledges support from the U.S. Army Research Lab Director's Strategic Initiative program on interfaces in stacked 2D atomic layers and materials. NR 29 TC 89 Z9 89 U1 88 U2 275 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 0036-8075 EI 1095-9203 J9 SCIENCE JI Science PD NOV 27 PY 2015 VL 350 IS 6264 BP 1065 EP 1068 DI 10.1126/science.aad2114 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CY5BJ UT WOS:000366422600037 PM 26612948 ER PT J AU Singamaneni, SR van Tol, J Ye, RQ Tour, JM AF Singamaneni, Srinivasa Rao van Tol, Johan Ye, Ruquan Tour, James M. TI Intrinsic and extrinsic defects in a family of coal-derived graphene quantum dots SO APPLIED PHYSICS LETTERS LA English DT Article ID ELECTRON-SPIN-RESONANCE; OXIDE; RELAXATION; GLASSES; ESR AB In this letter, we report on the high frequency (239.2 and 336 GHz) electron spin resonance (ESR) studies performed on graphene quantum dots (GQDs), prepared through a wet chemistry route from three types of coal: (a) bituminous, (h) anthracite, and (c) coke; and from non-coal derived GQDs. The microwave frequency-, power-, and temperature-dependent ESR spectra coupled with computer-aided simulations reveal four distinct magnetic defect centers. In bituminous- and anthracite-derived GQDs, we have identified two of them as intrinsic carbon-centered magnetic defect centers (a broad signal of peak to peak width = 697 (10(-4)T), g = 2.0023; and a narrow signal of peak to peak width = 697 (10(-4)T), g 2.003). The third defect center is Mn2 (6S5/2, 3d5) (signal width = 61 (10-4T), g = 2.0023, Ai = 93(10(-4) T)), and the fourth defect is identified as Cu2+ (2D572, 3e) (gi 2.048 and gll 2.279), previously undetected, Coke-derived and non-coal derived GQDs show Mn21 and two-carbon related signals, and no Cu2+ signal. The extrinsic impurities most likely originate from the starting coal. Furthermore, Raman, photoluminescence, and ESR measurements detected no noticeable changes in the properties of the bituminous GQDs after one year. This study highlights the importance of employing high frequency ESR spectroscopy in identifying the (magnetic) defects, which are roadblocks for spin relaxation times of graphene-based materials. These defects would not have been possible to probe by other spin transport measurements. (C) 2015 AIP Publishing LLC. C1 [Singamaneni, Srinivasa Rao] Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. [Singamaneni, Srinivasa Rao] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [van Tol, Johan] Florida State Univ, Natl High Magnet Field Lab, Tallahassee, FL 32310 USA. [Ye, Ruquan; Tour, James M.] Rice Univ, Dept Chem, Houston, TX 77005 USA. [Tour, James M.] Rice Univ, Dept Mat Sci & NanoEngn, Houston, TX 77005 USA. [Tour, James M.] Rice Univ, Smalley Inst Nanoscale Sci & Technol, Houston, TX 77005 USA. RP Singamaneni, SR (reprint author), Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. EM ssingam@ncsu.edu; tour@rice.edu OI Ye, Ruquan/0000-0002-2543-9090; Tour, James/0000-0002-8479-9328 FU NAS/NRC; NSF [DMR-1157490]; State of Florida; Air Force Office of Scientific Research [FA9550-14-1-0111] FX S.R.S. acknowledges NAS/NRC for postdoctoral fellowship. The National High Magnetic Field Laboratory was supported by NSF Cooperative Agreement No. DMR-1157490, and by the State of Florida. The work at Rice University was supported by the Air Force Office of Scientific Research FA9550-14-1-0111. We thank A. Metzger for synthesis of the non-coal derived GQDs. J.M.T. has interest in a company that has licensed technology on graphene quantum dot manufacture and applications. This is reported to and overseen by the Rice University Office of Research Compliance. NR 30 TC 2 Z9 2 U1 19 U2 52 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD NOV 23 PY 2015 VL 107 IS 21 AR 212402 DI 10.1063/1.4936204 PG 5 WC Physics, Applied SC Physics GA CX4NL UT WOS:000365677500028 ER PT J AU Rudraswami, NG Prasad, MS Dey, S Plane, JMC Feng, W Taylor, S AF Rudraswami, N. G. Prasad, M. Shyam Dey, S. Plane, J. M. C. Feng, W. Taylor, S. TI EVALUATING CHANGES IN THE ELEMENTAL COMPOSITION OF MICROMETEORITES DURING ENTRY INTO THE EARTH'S ATMOSPHERE SO ASTROPHYSICAL JOURNAL LA English DT Article DE atmospheric effects; Earth; interplanetary medium; meteorites, meteors, meteoroids; Sun: general ID COSMIC SPHERULES; INTERPLANETARY DUST; ACCRETION RATE; CARBONACEOUS CHONDRITES; GREENLAND ICE; SOUTH-POLE; ABLATION; FLUX; FRACTIONATIONS; CHONDRULES AB We evaluate the heating of extraterrestrial particles entering the atmosphere using the comprehensive chemical ablation model (CABMOD). This model predicts the ablation rates of individual elements in a particle with a defined size, composition, entry velocity, and entry angle with respect to the zenith (ZA). In the present study, bulk chemical analyses of 1133 Antarctica micrometeorites (collected from the south pole water well) are interpreted using CABMOD. The marked spread in Fe/Si values in unmelted, partially melted, and melted micrometeorites is explained by the loss of relatively volatile Fe during atmospheric entry. The combined theoretical modeling and elemental composition of the micrometeorites (Mg/Si ratios) suggest that similar to 85% of particles have a provenance of carbonaceous chondrites, the remaining similar to 15% are either ordinary or enstatite chondrites. About 65% of the micrometeorites have undergone <20% ablation, while a further 20% have lost between 20% and 60% of their original mass. This has implications for understanding the micrometeorite flux that reaches the Earth's surface, as well as estimating the pre-atmospheric size of the particles. Our work shows that the unmelted particles that. contribute similar to 50% to the total micrometeorite collection on Earth's surface have a small entry zone: ZA = 60 degrees-90 degrees if the entry velocity is similar to 11 km s(-1), and ZA = 80 degrees-90 degrees for >11-21 km s(-1). C1 [Rudraswami, N. G.; Prasad, M. Shyam; Dey, S.] Natl Inst Oceanog, Council Sci & Ind Research, Panaji 403004, Goa, India. [Dey, S.] Indian Inst Technol, Roorkee 247667, Uttarakhand, India. [Plane, J. M. C.; Feng, W.] Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England. [Taylor, S.] Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Rudraswami, NG (reprint author), Natl Inst Oceanog, Council Sci & Ind Research, Panaji 403004, Goa, India. EM rudra@nio.org RI Plane, John/C-7444-2015; Dey, Supratim/O-2435-2015; FENG, WUHU/B-8327-2008; OI Plane, John/0000-0003-3648-6893; Dey, Supratim/0000-0002-1354-5304; FENG, WUHU/0000-0002-9907-9120; Shyam Prasad, Mokkapati/0000-0001-6629-7482; N G, Rudraswami/0000-0002-3375-9860 FU CSIR; PLANEX project, Physical Research Laboratory, Ahmedabad; European Research Council [291332-CODITA] FX This work is supported by the CSIR XII Plan funded Project GEOSINKS and the PLANEX project, Physical Research Laboratory, Ahmedabad (N.G.R. and M.S.P.). This is NIO's contribution No. 5823. The work at the University of Leeds is supported by the European Research Council (project number 291332-CODITA). NR 52 TC 5 Z9 5 U1 5 U2 14 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0004-637X EI 1538-4357 J9 ASTROPHYS J JI Astrophys. J. PD NOV 20 PY 2015 VL 814 IS 1 AR 78 DI 10.1088/0004-637X/814/1/78 PG 11 WC Astronomy & Astrophysics SC Astronomy & Astrophysics GA CW9HQ UT WOS:000365310200078 ER PT J AU Yang, CSC Brown, E Kumi-Barimah, E Hommerich, U Jin, F Jia, YQ Trivedi, S D'Souza, AI Decuir, EA Wijewarnasuriya, PS Samuels, AC AF Yang, Clayton S. -C. Brown, Eiei Kumi-Barimah, Eric Hommerich, Uwe Jin, Feng Jia, Yingqing Trivedi, Sudhir D'Souza, Arvind I. Decuir, Eric A., Jr. Wijewarnasuriya, Priyalal S. Samuels, Alan C. TI Rapid long-wave infrared laser-induced breakdown spectroscopy measurements using a mercury-cadmium-telluride linear array detection system SO APPLIED OPTICS LA English DT Article ID ENERGETIC MATERIALS; SPECTRA; EMISSIONS; RAMAN; LIBS; OXYANION AB In this work, we develop a mercury-cadmium-telluride linear array detection system that is capable of rapidly capturing (similar to 1-5 s) a broad spectrum of atomic and molecular laser-induced breakdown spectroscopy (LIBS) emissions in the long-wave infrared (LWIR) region (similar to 5.6-10 mu m) . Similar to the conventional UV-Vis LIBS, a broadband emission spectrum of condensed phase samples covering the whole 5.6-10 mu m region can be acquired from just a single laser-induced microplasma or averaging a few single laser-induced microplasmas. Atomic and molecular signature emission spectra of solid inorganic and organic tablets and thin liquid films deposited on a rough asphalt surface are observed. This setup is capable of rapidly probing samples "as is" without the need of elaborate sample preparation and also offers the possibility of a simultaneous UV-Vis and LWIR LIBS measurement. (C) 2015 Optical Society of America C1 [Yang, Clayton S. -C.] Battelle Eastern Sci & Technol Ctr, Aberdeen, MD 21001 USA. [Brown, Eiei; Kumi-Barimah, Eric; Hommerich, Uwe] Hampton Univ, Dept Phys, Hampton, VA 23668 USA. [Jin, Feng; Jia, Yingqing; Trivedi, Sudhir] Brimrose Corp America, Baltimore, MD 21152 USA. [D'Souza, Arvind I.] DRS Sensors & Targeting Syst, Cypress, CA 90630 USA. [Decuir, Eric A., Jr.; Wijewarnasuriya, Priyalal S.] Army Res Lab, Adelphi, MD 20783 USA. [Samuels, Alan C.] Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Yang, CSC (reprint author), Battelle Eastern Sci & Technol Ctr, Aberdeen, MD 21001 USA. EM yangc@battelle.org FU Army Research Office (ARO) [W911NF-12-1-0049]; Defense Threat Reduction Agency (Novel Spectroscopy Initiative) [CB4059]; National Science Foundation (NSF) [HRD-1137747]; Small Business Innovative Research and Small Business Technology Transfer (SBIR/STTR) [W911SR-C-0022] FX Army Research Office (ARO) (W911NF-12-1-0049); Defense Threat Reduction Agency (Novel Spectroscopy Initiative) (CB4059); National Science Foundation (NSF) (HRD-1137747); Small Business Innovative Research and Small Business Technology Transfer (SBIR/STTR) (W911SR-C-0022). NR 29 TC 3 Z9 3 U1 3 U2 7 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD NOV 20 PY 2015 VL 54 IS 33 BP 9695 EP 9702 DI 10.1364/AO.54.009695 PG 8 WC Optics SC Optics GA CW4UB UT WOS:000364988100007 PM 26836525 ER PT J AU Suo, LM Borodin, O Gao, T Olguin, M Ho, J Fan, XL Luo, C Wang, CS Xu, K AF Suo, Liumin Borodin, Oleg Gao, Tao Olguin, Marco Ho, Janet Fan, Xiulin Luo, Chao Wang, Chunsheng Xu, Kang TI "Water-in-salt" electrolyte enables high-voltage aqueous lithium-ion chemistries SO SCIENCE LA English DT Article ID PROPYLENE CARBONATE; CYCLING STABILITY; RECHARGEABLE LI; ENERGY-STORAGE; BATTERIES; TRANSPORT; ANODE; INTERCALATION; CHALLENGES; SOLVATION AB Lithium-ion batteries raise safety, environmental, and cost concerns, which mostly arise from their nonaqueous electrolytes. The use of aqueous alternatives is limited by their narrow electrochemical stability window (1.23 volts), which sets an intrinsic limit on the practical voltage and energy output. We report a highly concentrated aqueous electrolyte whose window was expanded to similar to 3.0 volts with the formation of an electrode-electrolyte interphase. A full lithium-ion battery of 2.3 volts using such an aqueous electrolyte was demonstrated to cycle up to 1000 times, with nearly 100% coulombic efficiency at both low (0.15 coulomb) and high (4.5 coulombs) discharge and charge rates. C1 [Suo, Liumin; Gao, Tao; Fan, Xiulin; Luo, Chao; Wang, Chunsheng] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20740 USA. [Borodin, Oleg; Olguin, Marco; Ho, Janet; Xu, Kang] US Army Res Lab, Electrochem Branch, Sensor & Electron Devices Directorate, Power & Energy Div, Adelphi, MD 20783 USA. RP Wang, CS (reprint author), Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20740 USA. EM cswang@umd.edu; conrad.k.xu.civ@mail.mil RI Wang, Chunsheng/H-5767-2011; Borodin, Oleg/B-6855-2012 OI Wang, Chunsheng/0000-0002-8626-6381; Borodin, Oleg/0000-0002-9428-5291 FU DOE ARPA-E [DEAR0000389]; Maryland Nano Center; NispLab; NSF as a MRSEC Shared Experimental Facility; Oak Ridge Associated Universities postdoctoral fellowship FX C.W. and K.X. gratefully acknowledge both funding and inspiration from P. Liu of DOE ARPA-E (DEAR0000389). We also acknowledge the support of the Maryland Nano Center and its NispLab. The NispLab is supported in part by the NSF as a MRSEC Shared Experimental Facility. We thank K. Gaskell, Y.-F. Lam, S.-C. Liou, A. Goyal, and S. R. Raghavan for technical support and helpful discussions. Modeling efforts were supported by ARL Enterprise for Multiscale Research of Materials. M.O. was supported by an Oak Ridge Associated Universities postdoctoral fellowship. NR 41 TC 77 Z9 77 U1 101 U2 339 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 0036-8075 EI 1095-9203 J9 SCIENCE JI Science PD NOV 20 PY 2015 VL 350 IS 6263 BP 938 EP 943 DI 10.1126/science.aab1595 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CW4IP UT WOS:000364955200040 PM 26586759 ER PT J AU Myles, TD Grew, KN Peracchio, AA Chiu, WKS AF Myles, Timothy D. Grew, Kyle N. Peracchio, Aldo A. Chiu, Wilson K. S. TI Transient ion exchange of anion exchange membranes exposed to carbon dioxide SO JOURNAL OF POWER SOURCES LA English DT Article DE Anion exchange membrane; Carbonate; Bicarbonate; Carbon dioxide; Transient ID ELECTROLYTE FUEL-CELLS; GAS-DIFFUSION LAYER; PROTON TRANSPORT; SELF-DIFFUSION; ALKALINE MEDIA; WATER-UPTAKE; CONDUCTIVITY; TEMPERATURE; SIMULATION; HYDROXIDE AB A common issue with anion exchange membranes (AEMs) is carbon dioxide contamination which causes a conversion from the hydroxide form to a mixed carbonate/bicarbonate form. In the mixed ionic form the membrane suffers from lower conductivity due to the larger and heavier ions having a lower mobility. The purpose of this study is to develop a theoretical model of the transient ion exchange process and elucidate the nature of the conversion of the AEM from a hydroxide form to a carbonate/bicarbonate form. Experimental data available from the literature providing the anion concentrations versus time are used for comparison. The prevalent mechanisms are discussed and the governing equations are cast in a dimensionless form. Extensions are then made to conductivity predictions. (C) 2015 Elsevier B.V. All rights reserved. C1 [Myles, Timothy D.; Peracchio, Aldo A.; Chiu, Wilson K. S.] Univ Connecticut, Dept Mech Engn, Storrs, CT 06269 USA. [Grew, Kyle N.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Chiu, WKS (reprint author), Univ Connecticut, Dept Mech Engn, Storrs, CT 06269 USA. EM wchiu@engr.uconn.edu FU Army Research Office [W911NF-14-1-0298]; U.S. Department of the Army; U.S. Army Materiel Command FX T.D.M., A.A.P. and W.K.S.C. acknowledge financial support from the Army Research Office (award number W911NF-14-1-0298). T.D.M. gratefully acknowledges a 2013 summer internship at the U.S. Army Research Laboratory made possible through the Science and Engineering Apprenticeship Program - College Qualified Leaders (SEAP-CQL). K.N.G. gratefully acknowledges support from the U.S. Department of the Army and U.S. Army Materiel Command. The authors would also like to acknowledge the support of and discussions with Dr. Cynthia Lundgren and Dr. Deryn Chu of the U.S. Army Research Laboratory. The views and conclusions are those of the authors and should not be interpreted as representing official policies, either expressed or implied, of the U.S. Army Research Laboratory or the U.S. Government. The authors thank Prof. William E. Mustain and Prof. Ugur Pasaogullari of the University of Connecticut for the discussion. NR 60 TC 2 Z9 2 U1 5 U2 48 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 EI 1873-2755 J9 J POWER SOURCES JI J. Power Sources PD NOV 20 PY 2015 VL 296 BP 225 EP 236 DI 10.1016/j.jpowsour.2015.07.044 PG 12 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA CQ7IP UT WOS:000360776500028 ER PT J AU Arabi, Y Balkhy, H Hajeer, AH Bouchama, A Hayden, FG Al-Omari, A Al-Hameed, FM Taha, Y Shindo, N Whitehead, J Merson, L AlJohani, S Al-Khairy, K Carson, G Luke, TC Hensley, L Al-Dawood, A Al-Qahtani, S Modjarrad, K Sadat, M Rohde, G Leport, C Fowler, R AF Arabi, Yaseen Balkhy, Hanan Hajeer, Ali H. Bouchama, Abderrezak Hayden, Frederick G. Al-Omari, Awad Al-Hameed, Fahad M. Taha, Yusri Shindo, Nahoko Whitehead, John Merson, Laura AlJohani, Sameera Al-Khairy, Khalid Carson, Gail Luke, Thomas C. Hensley, Lisa Al-Dawood, Abdulaziz Al-Qahtani, Saad Modjarrad, Kayvon Sadat, Musharaf Rohde, Gernot Leport, Catherine Fowler, Robert TI Feasibility, safety, clinical, and laboratory effects of convalescent plasma therapy for patients with Middle East respiratory syndrome coronavirus infection: a study protocol SO SPRINGERPLUS LA English DT Article DE Middle east respiratory syndrome coronavirus; MERS-CoV; Viral pneumonia; Intensive care; Convalescent plasma; Serology; Genome; Neutralizing antibodies ID SAUDI-ARABIA; INFLUENZA; PNEUMONIA AB As of September 30, 2015, a total of 1589 laboratory-confirmed cases of infection with the Middle East respiratory syndrome coronavirus (MERS-CoV) have been reported to the World Health Organization (WHO). At present there is no effective specific therapy against MERS-CoV. The use of convalescent plasma (CP) has been suggested as a potential therapy based on existing evidence from other viral infections. We aim to study the feasibility of CP therapy as well as its safety and clinical and laboratory effects in critically ill patients with MERS-CoV infection. We will also examine the pharmacokinetics of the MERS-CoV antibody response and viral load over the course of MERS-CoV infection. This study will inform a future randomized controlled trial that will examine the efficacy of CP therapy for MERS-CoV infection. In the CP collection phase, potential donors will be tested by the enzyme linked immunosorbent assay (ELISA) and the indirect fluorescent antibody (IFA) techniques for the presence of anti-MERS-CoV antibodies. Subjects with anti-MERS-CoV IFA titer of >= 1:160 and no clinical or laboratory evidence of MERS-CoV infection will be screened for eligibility for plasma donation according to standard donation criteria. In the CP therapy phase, 20 consecutive critically ill patients admitted to intensive care unit with laboratory-confirmed MERS-CoV infection will be enrolled and each will receive 2 units of CP. Post enrollment, patients will be followed for clinical and laboratory outcomes that include anti-MERS-CoV antibodies and viral load. This protocol was developed collaboratively by King Abdullah International Medical Research Center (KAIMRC), Gulf Cooperation Council (GCC) Infection Control Center Group and the World Health Organization-International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC-WHO) MERS-CoV Working Group. It was approved in June 2014 by the Ministry of the National Guard Health Affairs Institutional Review Board (IRB). A data safety monitoring board (DSMB) was formulated. The study is registered at http://www.clinicaltrials.gov (NCT02190799). C1 [Arabi, Yaseen; Bouchama, Abderrezak; Al-Dawood, Abdulaziz; Al-Qahtani, Saad] King Saud bin Abdulaziz Univ Hlth Sci, King Abdulaziz Med City, King Abdullah Int Med Res Ctr, Intens Care Dept,Resp Serv,Coll Med, POB 22490, Riyadh 11426, Saudi Arabia. [Balkhy, Hanan] King Saud bin Abdulaziz Univ Hlth Sci, King Abdulaziz Med City, King Abdullah Int Med Res Ctr, Infect Control Dept, Riyadh, Saudi Arabia. [Hajeer, Ali H.; AlJohani, Sameera; Al-Khairy, Khalid] King Saud bin Abdulaziz Univ Hlth Sci, King Abdulaziz Med City, Pathol & Lab Dept, Riyadh, Saudi Arabia. [Hayden, Frederick G.] Univ Virginia, Sch Med, Dept Med, Div Infect Dis & Int Hlth, Charlottesville, VA 22908 USA. [Al-Omari, Awad] AlFaisal Univ, Secur Forces Hosp, Crit Care & Infect Control Dept, Riyadh, Saudi Arabia. [Al-Hameed, Fahad M.] King Saud bin Abdulaziz Univ Hlth Sci, King Abdulaziz Med City, Dept Intens Care, Jeddah, Saudi Arabia. [Taha, Yusri] King Abdul Aziz Med City, Dept Med Infect Dis, Al Hasa, Saudi Arabia. [Shindo, Nahoko] World Hlth Org, Pandem & Epidem Dis Dept, Geneva, Switzerland. [Whitehead, John] Univ Lancaster, Dept Math & Stat, Lancaster, England. [Merson, Laura] Univ Oxford, Clin Res Unit, Ho Chi Minh City, Vietnam. [Carson, Gail] Univ Oxford, Ctr Trop Med CCVTM, Oxford OX3 7LE, England. [Luke, Thomas C.] Henry Jackson Fdn, Naval Med Res Ctr, Viral & Rickettsial Dis Dept, Bethesda, MD 20817 USA. [Hensley, Lisa] NIAID, Integrated Res Facil, Frederick, MD USA. [Modjarrad, Kayvon] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Sadat, Musharaf] King Abdul Aziz Med City, Dept Intens Care, Riyadh, Saudi Arabia. [Rohde, Gernot] Maastricht Univ, Med Ctr, Dept Resp Med, NL-6202 AZ Maastricht, Netherlands. [Leport, Catherine] Univ Paris Diderot, French Infect Dis Soc, Paris, France. [Fowler, Robert] Univ Toronto, AMR Infect Control & Publicat AIP PED HSE HQ, Dept Med, Toronto, ON, Canada. [Fowler, Robert] Univ Toronto, AMR Infect Control & Publicat AIP PED HSE HQ, Inst Hlth Policy Management & Evaluat, Toronto, ON, Canada. [Fowler, Robert] Sunnybrook Hlth Sci Ctr, Dept Crit Care Med, Toronto, ON M4N 3M5, Canada. [Fowler, Robert] Sunnybrook Hlth Sci Ctr, Dept Med, Toronto, ON M4N 3M5, Canada. RP Arabi, Y (reprint author), King Saud bin Abdulaziz Univ Hlth Sci, King Abdulaziz Med City, King Abdullah Int Med Res Ctr, Intens Care Dept,Resp Serv,Coll Med, POB 22490, Riyadh 11426, Saudi Arabia. EM arabi@ngha.med.sa RI Rohde, Gernot/F-3060-2013; OI Rohde, Gernot/0000-0002-5193-7755; Hajeer, Ali/0000-0003-2727-9964 FU King Abdullah International Medical Research Center, Riyadh, Saudi Arabia FX This project is funded by King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. NR 15 TC 6 Z9 6 U1 0 U2 5 PU SPRINGER INTERNATIONAL PUBLISHING AG PI CHAM PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND SN 2193-1801 J9 SPRINGERPLUS JI SpringerPlus PD NOV 19 PY 2015 VL 4 AR 709 DI 10.1186/s40064-015-1490-9 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DB7QA UT WOS:000368709400005 PM 26618098 ER PT J AU Wang, ZF He, HY Slough, W Pandey, R Karna, SP AF Wang, Zhoufei He, Haiying Slough, William Pandey, Ravindra Karna, Shashi P. TI Nature of Interaction between Semiconducting Nanostructures and Biomolecules: Chalcogenide QDs and BNNT with DNA Molecules SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID BORON-NITRIDE NANOTUBES; EFFECTIVE CORE POTENTIALS; QUANTUM DOTS; DISPERSION; CLUSTERS; DENSITY; CYTOCOMPATIBILITY; NANOMATERIALS; NUCLEOBASES; ADSORPTION AB Interactions of DNA oligomers with two categories of semiconducting nanostructures-chalcogenide quantum dots (QDs) and boron nitride nanotubes (BNNTs)-owing to their widespread presence in bio-inspired processes are investigated using the first-principles density functional theory and continuum solvent model. The chalcogenide QDs interact strongly at their metal centers featuring electrostatic interaction with DNA oligomers at oxygen or nitrogen site, while BNNTs form covalent bonds with DNA oligomers at multiple surface sites. It is found that the different bonding nature leads to distinctly different response to the aqueous environment; the presence of solvent drastically reduces the binding strength of nucleobases with the QDs due to the strong electrostatic screening. This is not the case with BNNTs for which the covalent bonding is barely affected by the solvent. This study thus clearly shows how a solvent medium influences chemical interactions providing guidance for technological applications of bioconjugated systems. C1 [Wang, Zhoufei; Slough, William; Pandey, Ravindra] Michigan Technol Univ, Houghton, MI 49931 USA. [Wang, Zhoufei] South China Agr Univ, Guangzhou 510642, Guangdong, Peoples R China. [He, Haiying] Valparaiso Univ, Dept Phys & Astron, Valparaiso, IN 46383 USA. [Karna, Shashi P.] US Army Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA. RP He, HY (reprint author), Valparaiso Univ, Dept Phys & Astron, Valparaiso, IN 46383 USA. EM haiying.he@valpo.edu; pandey@mtu.edu; shashi.p.karna.civ@mail.mil NR 46 TC 3 Z9 3 U1 4 U2 14 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD NOV 19 PY 2015 VL 119 IS 46 BP 25965 EP 25973 DI 10.1021/acs.jpcc.5b08084 PG 9 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA CX1NN UT WOS:000365463000031 ER PT J AU Dong, H Sliozberg, YR Snyder, JF Steele, J Chantawansri, TL Orlicki, JA Walck, SD Reiner, RS Rudie, AW AF Dong, Hong Sliozberg, Yelena R. Snyder, James F. Steele, Joshua Chantawansri, Tanya L. Orlicki, Joshua A. Walck, Scott D. Reiner, Richard S. Rudie, Alan W. TI Highly Transparent and Toughened Poly(methyl methacrylate) Nanocomposite Films Containing Networks of Cellulose Nanofibrils SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE cellulose nanofibrils; poly(methyl methacrylate); nanocomposites; interfacial interactions; mechanical properties; coarse-grained simulation ID MOLECULAR-DYNAMICS; CARBON NANOTUBES; POLYMER; NANOPARTICLES; SIMULATIONS; COMPOSITES; BEHAVIOR; ACID AB Cellulose nanofibrils (CNFs) are a class of cellulosic nanomaterials with high aspect ratios that can be extracted from various natural sources. Their highly crystalline structures provide the nanofibrils with excellent mechanical and thermal properties. The main challenges of CNFs in nanocomposite applications are associated with their high hydrophilicity, which makes CNFs incompatible with hydrophobic polymers. In this study, highly transparent and toughened poly(methyl methacrylate) (PMMA) nanocomposite films were prepared using various percentages of CNFs covered with surface carboxylic acid groups (CNF-COOH). The surface groups make the CNFs interfacial interaction with PMMA favorable, which facilitate the homogeneous dispersion of the hydrophilic nanofibrils in the hydrophobic polymer and the formation of a percolated network of nanofibrils. The controlled dispersion results in high transparency of the nanocomposites. Mechanical analysis of the resulting films demonstrated that a low percentage loading of CNF-COOH worked as effective reinforcing agents, yielding more ductile and therefore tougher films than the neat PMMA film. Toughening mechanisms were investigated through coarse-grained simulations, where the results demonstrated that a favorable polymer-nanofibril interface together with percolation of the nanofibrils, both facilitated through hydrogen bonding interactions, contributed to the toughness improvement in these nanocomposites. C1 [Dong, Hong; Sliozberg, Yelena R.; Snyder, James F.; Steele, Joshua; Chantawansri, Tanya L.; Orlicki, Joshua A.; Walck, Scott D.] US Army, Res Lab, Macromol Sci & Technol Branch, Aberdeen Proving Ground, MD 21005 USA. [Dong, Hong; Sliozberg, Yelena R.; Walck, Scott D.] TKC Global Solut LLC, Aberdeen, MD 21005 USA. [Reiner, Richard S.; Rudie, Alan W.] US Forest Serv, USDA, Forest Prod Lab, Madison, WI 53726 USA. RP Dong, H (reprint author), US Army, Res Lab, Biotechnol Branch, Adelphi, MD 20783 USA. EM hong.dong.ctr@mail.mil FU U.S. Army Research Laboratory [W911QX-14-C-0016]; U.S. Army Research Laboratory FX The research reported in this document was performed in connection with contract/instrument W911QX-14-C-0016 with the U.S. Army Research Laboratory. J. Steele was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARL. The authors thank Dr. Randy Mrozek, Dr. Erich Bain, and Mr. Eugene Napadensky at U.S. Army Research Laboratory for useful discussions. NR 32 TC 6 Z9 6 U1 15 U2 60 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD NOV 18 PY 2015 VL 7 IS 45 BP 25464 EP 25472 DI 10.1021/acsami.5b08317 PG 9 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA CW6ZW UT WOS:000365148600057 PM 26513136 ER PT J AU Becker, CR Gillen, GJ Staymates, ME Stoldt, CR AF Becker, Collin R. Gillen, Greg J. Staymates, Matthew E. Stoldt, Conrad R. TI Nanoporous Silicon Combustion: Observation of Shock Wave and Flame Synthesis of Nano-particle Silica SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE porous silicon; ball lightning; nanothermite; nanoenergetic; Raman spectroscopy; MEMS ID GALVANIC POROUS SILICON; NANOPARTICLES; MICROCHANNELS; FABRICATION; CELLS; LAYER; FILMS AB The persistent hydrogen termination present in nanoporous silicon (nPS) is unique compared to other forms of nanoscale silicon (Si) which typically readily form a silicon dioxide passivation layer. The hydrogen terminated surface combined with the extremely high surface area of nPS yields a material capable of powerful exothermic reactions when combined with strong oxidizers. Here, a galvanic etching mechanism is used to produce nPS both in bulk Si wafers as well as in patterned regions of Si wafers with microfabricated ignition wires. An explosive composite is generated by filling the pores with sodium perchlorate (NaClO4). Using high-speed video including Schlieren photography, a shock wave is observed to propagate through air at 1127 +/- 116 m/s. Additionally, a fireball is observed above the region of nPS combustion which persists for nearly 3x as long when reacted in air compared to N-2, indicating that highly reactive species are generated that can further combust with excess oxygen. Finally, reaction products from either nPS-NaClO4 composites or nPS alone combusted with only high pressure O-2 (400 psig) gas as an oxidizer are captured in a calorimeter bomb. The products in both cases are similar and verified by transmission electron microscopy (TEM) to include nano- to micrometer scale SiOx particles. This work highlights the complex oxidation mechanism of nPS composites and demonstrates the ability to use a solid state reaction to create a secondary gas phase combustion. C1 [Becker, Collin R.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Gillen, Greg J.; Staymates, Matthew E.] NIST, Gaithersburg, MD 20899 USA. [Stoldt, Conrad R.] Univ Colorado, Dept Mech Engn, Boulder, CO 80309 USA. RP Becker, CR (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM Collin.r.becker.civ@mail.mil FU U.S. Army Research Lab; DOD SMART scholarship FX We are grateful for financial support from the U.S. Army Research Lab. C.R.B. also acknowledges support from a DOD SMART scholarship. NR 49 TC 0 Z9 0 U1 9 U2 34 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD NOV 18 PY 2015 VL 7 IS 45 BP 25539 EP 25545 DI 10.1021/acmasi.5b09076 PG 7 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA CW6ZW UT WOS:000365148600066 PM 26501940 ER PT J AU Deppe, JL Ward, MP Bolus, RT Diehl, RH Celis-Murillo, A Zenzal, TJ Moore, FR Benson, TJ Smolinsky, JA Schofield, LN Enstrom, DA Paxton, EH Bohrer, G Beveroth, TA Raim, A Obringer, RL Delaney, D Cochran, WW AF Deppe, Jill L. Ward, Michael P. Bolus, Rachel T. Diehl, Robert H. Celis-Murillo, Antonio Zenzal, Theodore J., Jr. Moore, Frank R. Benson, Thomas J. Smolinsky, Jaclyn A. Schofield, Lynn N. Enstrom, David A. Paxton, Eben H. Bohrer, Gil Beveroth, Tara A. Raim, Arlo Obringer, Renee L. Delaney, David Cochran, William W. TI Fat, weather, and date affect migratory songbirds' departure decisions, routes, and time it takes to cross the Gulf of Mexico SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE migration; ecological barrier; Gulf of Mexico; songbirds; weather ID RED-EYED VIREOS; ENERGETIC CONDITION; SPRING MIGRATION; SWAINSONS THRUSH; BIRD ORIENTATION; FALL MIGRATION; STOPOVER SITES; MIGRANTS; WIND; LOUISIANA AB Approximately two thirds of migratory songbirds in eastern North America negotiate the Gulf of Mexico (GOM), where inclement weather coupled with no refueling or resting opportunities can be lethal. However, decisions made when navigating such features and their consequences remain largely unknown due to technological limitations of tracking small animals over large areas. We used automated radio telemetry to track three songbird species (Red-eyed Vireo, Swainson's Thrush, Wood Thrush) from coastal Alabama to the northern Yucatan Peninsula (YP) during fall migration. Detecting songbirds after crossing similar to 1,000 km of open water allowed us to examine intrinsic (age, wing length, fat) and extrinsic (weather, date) variables shaping departure decisions, arrival at the YP, and crossing times. Large fat reserves and low humidity, indicative of beneficial synoptic weather patterns, favored southward departure across the Gulf. Individuals detected in the YP departed with large fat reserves and later in the fall with profitable winds, and flight durations (mean = 22.4 h) were positively related to wind profit. Age was not related to departure behavior, arrival, or travel time. However, vireos negotiated the GOM differently than thrushes, including different departure decisions, lower probability of detection in the YP, and longer crossing times. Defense of winter territories by thrushes but not vireos and species-specific foraging habits may explain the divergent migratory behaviors. Fat reserves appear extremely important to departure decisions and arrival in the YP. As habitat along the GOM is degraded, birds may be limited in their ability to acquire fat to cross the Gulf. C1 [Deppe, Jill L.; Schofield, Lynn N.] Eastern Illinois Univ, Dept Biol Sci, Charleston, IL 61920 USA. [Ward, Michael P.; Bolus, Rachel T.; Celis-Murillo, Antonio] Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA. [Bolus, Rachel T.; Diehl, Robert H.] US Geol Survey, No Rocky Mt Sci Ctr, Bozeman, MT 59715 USA. [Zenzal, Theodore J., Jr.; Moore, Frank R.] Univ So Mississippi, Dept Biol Sci, Hattiesburg, MS 39406 USA. [Benson, Thomas J.; Enstrom, David A.; Beveroth, Tara A.; Raim, Arlo; Cochran, William W.] Univ Illinois, Illinois Nat Hist Survey, Champaign, IL 61820 USA. [Smolinsky, Jaclyn A.] Univ Delaware, Dept Entomol & Wildlife Ecol, Newark, DE 19716 USA. [Paxton, Eben H.] US Geol Survey, Pacific Isl Ecosyst Res Ctr, Hawaii Natl Pk, HI 96718 USA. [Bohrer, Gil; Obringer, Renee L.] Ohio State Univ, Dept Civil Environm & Geodet Engn, Columbus, OH 43210 USA. [Delaney, David] US Army Corps Engineers, Construct Engn Res Lab, Champaign, IL 61822 USA. RP Deppe, JL (reprint author), Eastern Illinois Univ, Dept Biol Sci, Charleston, IL 61920 USA. EM jldeppe@eiu.edu RI Celis Murillo, Antonio/A-3651-2013; OI Celis Murillo, Antonio/0000-0002-3371-6529; Bohrer, Gil/0000-0002-9209-9540; Paxton, Eben/0000-0001-5578-7689 FU National Science Foundation (NSF) (IOS) [1147096, 1145952, 1147022]; National Geographic Society Committee on Research and Exploration [897111]; American Ornithologists' Union; Birmingham Audubon Society; Eastern Illinois University; University of Illinois Urbana-Champaign; University of Southern Mississippi; NASA [NNX11AP61G]; NSF [0947944] FX We thank our numerous field technicians at The University of Southern Mississippi Fort Morgan Peninsula Banding Station, and Melgar Tabasco and Waldemar Santamaria for assistance in the Yucatan Peninsula. We also thank our many site partners around the Gulf for granting permission to install and operate telemetry equipment. Thanks to Sarah Davidson (Movebank curator) and Rolf Weinzierl who assisted us with archiving our movement data and accessing atmospheric data. Janet Ruth and three anonymous reviewers provided valuable feedback on earlier drafts of this paper. This work was supported by the National Science Foundation (NSF) (IOS Awards 1147096, 1145952, and 1147022), National Geographic Society Committee on Research and Exploration (Award 897111), American Ornithologists' Union (J.A.S.), Birmingham Audubon Society (J.A.S.), Eastern Illinois University (Research and Creative Activity Awards to J.L.D. and L.N.S.), University of Illinois Urbana-Champaign, and The University of Southern Mississippi. G.B. was supported by NASA Award NNX11AP61G. T.J.Z. was supported by a NSF GK-12 Program Award (0947944). Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the US Government. NR 91 TC 18 Z9 18 U1 13 U2 46 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD NOV 17 PY 2015 VL 112 IS 46 BP E6331 EP E6338 DI 10.1073/pnas.1503381112 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CW7IA UT WOS:000365170400012 PM 26578793 ER PT J AU Chandrasekaran, L Lal, M Van De Verg, LL Venkatesan, MM AF Chandrasekaran, Lakshmi Lal, Manjari Van De Verg, Lillian L. Venkatesan, Malabi M. TI A study of different buffers to maximize viability of an oral Shigella vaccine SO VACCINE LA English DT Article DE S. sonnei vaccine; WRSS1 vaccine; Acid neutralization buffer; Vaccine viability ID CHOLERA VACCINE; IMMUNE-RESPONSES; CHALLENGE MODEL; HEALTHY-ADULTS; B-SUBUNIT; IMMUNOGENICITY; VOLUNTEERS; LIVE; STRAIN; CHILDREN AB Live, whole cell killed and subunit vaccines are being developed for diarrheal diseases caused by V. cholerae, Shigella species, ETEC, and Campylobacter. Some of these vaccines can be administered orally since this route best mimics natural infection. Live vaccines administered orally have to be protected from the harsh acidic gastric environment. Milk and bicarbonate solutions have been administered to neutralize the stomach acid. For many Shigella vaccine trials, 100-120 ml of a bicarbonate solution is ingested followed by the live vaccine candidate, which is delivered in 30 ml of bicarbonate, water or saline. It is not clear if maximum bacterial viability is achieved under these conditions. Also, volumes of neutralizing buffer that are optimal for adults may be unsuitable for children and infants. To address these questions, we performed studies to determine the viability and stability of a Shigella sonnei vaccine candidate, WRSS1, in a mixture of different volumes of five different buffer solutions added to hydrochloric acid to simulate gastric acidity. Among the buffers tested, bicarbonate solution, rotavirus buffer and CeraVacx were better at neutralizing acid and maintaining the viability of WRSS1. Also, a much smaller volume of the neutralizing buffer was sufficient to counteract stomach acid while maintaining bacterial viability. Published by Elsevier Ltd. C1 [Chandrasekaran, Lakshmi; Venkatesan, Malabi M.] Walter Reed Army Inst Res, Bacterial Dis Branch, Silver Spring, MD 20910 USA. [Lal, Manjari; Van De Verg, Lillian L.] PATH, Enter Vaccines Initiat, Seattle, WA USA. RP Venkatesan, MM (reprint author), Walter Reed Army Inst Res, Bacterial Dis Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM malabi.m.venkatesan.civ@mail.mil FU Military Infectious Disease Research Program (MIDRP); PATH, EVI FX Funding for this work was provided by Military Infectious Disease Research Program (MIDRP) and a Cooperative Research and Development Agreement (CRADA) with PATH, EVI. NR 21 TC 0 Z9 0 U1 0 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD NOV 17 PY 2015 VL 33 IS 46 BP 6156 EP 6160 DI 10.1016/j.vaccine.2015.09.063 PG 5 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA CX0CI UT WOS:000365364100006 PM 26428454 ER PT J AU Potter, AW Gonzalez, JA Xu, XJ AF Potter, Adam W. Gonzalez, Julio A. Xu, Xiaojiang TI Ebola Response: Modeling the Risk of Heat Stress from Personal Protective Clothing SO PLOS ONE LA English DT Article ID LIQUID COOLING SYSTEMS; VIRUS DISEASE; INTERMITTENT; EXERCISE; DESIGN; STRAIN; BODY; EFFICACY; GARMENTS AB Introduction A significant number of healthcare workers have responded to aid in the relief and containment of the 2013 Ebola virus disease (EVD) outbreak in West Africa. Healthcare workers are required to wear personal protective clothing (PPC) to impede the transmission of the virus; however, the impermeable design and the hot humid environment lead to risk of heat stress. Objective Provide healthcare workers quantitative modeling and analysis to aid in the prevention of heat stress while wearing PPC in West Africa. Methods A sweating thermal manikin was used to measure the thermal (R-ct) and evaporative resistance (R-et) of the five currently used levels of PPC for healthcare workers in the West Africa EVD response. Mathematical methods of predicting the rise in core body temperature (T-c) in response to clothing, activity, and environment was used to simulate different responses to PPC levels, individual body sizes, and two hot humid conditions: morning/evening (air temperature: 25 degrees C, relative humidity: 40%, mean radiant temperature: 35 degrees C, wind velocity: 1 m/s) and mid-day (30 degrees C, 60%, 70 degrees C, 1 m/s). Results Nearly still air (0.4 m/s) measures of Rct ranged from 0.18 to 0.26 m(2) K/W and R-et ranged from 25.53 to 340.26 m(2) Pa/W. Conclusion Biophysical assessments and modeling in this study provide quantitative guidance for prevention of heat stress of healthcare workers wearing PPC responding to the EVD outbreak in West Africa. C1 [Potter, Adam W.; Gonzalez, Julio A.; Xu, Xiaojiang] US Army, Biophys & Biomed Modeling Div, Environm Med Res Inst, Natick, MA 01760 USA. RP Potter, AW (reprint author), US Army, Biophys & Biomed Modeling Div, Environm Med Res Inst, Natick, MA 01760 USA. EM adam.w.potter.civ@mail.mil NR 32 TC 2 Z9 2 U1 0 U2 10 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 17 PY 2015 VL 10 IS 11 AR e0143461 DI 10.1371/journal.pone.0143461 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CW7BR UT WOS:000365153400062 PM 26575389 ER PT J AU King, J Howell, S Derksen, C Rutter, N Toose, P Beckers, JF Haas, C Kurtz, N Richter-Menge, J AF King, Joshua Howell, Stephen Derksen, Chris Rutter, Nick Toose, Peter Beckers, Justin F. Haas, Christian Kurtz, Nathan Richter-Menge, Jacqueline TI Evaluation of Operation IceBridge quick-look snow depth estimates on sea ice SO GEOPHYSICAL RESEARCH LETTERS LA English DT Article ID THICKNESS RETRIEVAL; RADAR; CRYOSAT-2; FREEBOARD; BAND; IMPACT; SHEBA AB We evaluate Operation IceBridge (OIB) "quick-look" snow depth on sea ice retrievals using in situ measurements taken over immobile first-year ice (FYI) and multiyear ice (MYI) during March of 2014. Good agreement was found over undeformed FYI (-4.5 cm mean bias) with reduced agreement over deformed FYI (-6.6 cm mean bias). Over MYI, the mean bias was -5.7 cm, but 54% of retrievals were discarded by the OIB retrieval process as compared to only 10% over FYI. Footprint scale analysis revealed a root-mean-square error (RMSE) of 6.2 cm over undeformed FYI with RMSE of 10.5 cm and 17.5 cm in the more complex deformed FYI and MYI environments. Correlation analysis was used to demonstrate contrasting retrieval uncertainty associated with spatial aggregation and ice surface roughness. C1 [King, Joshua; Howell, Stephen; Derksen, Chris; Toose, Peter] Environm Canada, Climate Res Div, Toronto, ON, Canada. [Rutter, Nick] Northumbria Univ, Dept Geog, Newcastle Upon Tyne NE1 8ST, Tyne & Wear, England. [Beckers, Justin F.; Haas, Christian] Univ Alberta, Dept Earth & Atmospher Sci, Edmonton, AB, Canada. [Haas, Christian] York Univ, Dept Earth & Space Sci & Engn, Toronto, ON M3J 2R7, Canada. [Kurtz, Nathan] NASA, Goddard Space Flight Ctr, Hydrospher & Biospher Sci Lab, Greenbelt, MD 20771 USA. [Richter-Menge, Jacqueline] Engn Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH USA. RP King, J (reprint author), Environm Canada, Climate Res Div, Toronto, ON, Canada. EM joshua.king@ec.gc.ca RI Rutter, Nick/F-6998-2014; Beckers, Justin/I-2806-2014; Haas, Christian/L-5279-2016 OI Rutter, Nick/0000-0002-5008-3575; Beckers, Justin/0000-0003-0751-3995; Haas, Christian/0000-0002-7674-3500 FU Canadian Space Agency through the Government Related Initiatives Program (GRIP); European Space Agency (ESA) through the CryoSat Validation Experiment (CryoVEx) program; Canada Research Chair program FX OIB data sets used in this letter are available from the NSIDC. QL estimates can be found at https://nsidc.org/data/docs/daac/icebridge/evaluation_products/sea-ice-f reeboard-snowdepth-thickness-quicklook-index.html, data sets: OIB_20140325_IDCSI2 and OIB_20140331_IDCSI2. OIB ATM and POS/AV instrument data are found at http://nsidc.org/data/icebridge/instr_data_summary.html, data sets: ILATM1B_20140325*, ILATM1B_20140331*, sbet_20140325, and sbet_20140331. FYI field measurements may be obtained from Environment Canada. MYI field measurements are available at https://earth.esa.int/web/guest/campaigns. RADARSAT-2 imagery used in this letter was made available from the CSA/PSTG and can be acquired for a fee through the National Earth Observation Data Framework web page (https://neodf.nrcan.gc.ca/neodf_cat3/). The FYI field campaign was funded by the Canadian Space Agency through the Government Related Initiatives Program (GRIP). The MYI field campaign was funded by the European Space Agency (ESA) through the CryoSat Validation Experiment (CryoVEx) program. We acknowledge additional support from the Canada Research Chair program. Thank you to the OIB flight and science teams for their efforts to coordinate data collection. Thank you to Bruce Elder and Chris Hiemstra for their contributions to the CryoVEx field campaign. NR 29 TC 0 Z9 0 U1 0 U2 5 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0094-8276 EI 1944-8007 J9 GEOPHYS RES LETT JI Geophys. Res. Lett. PD NOV 16 PY 2015 VL 42 IS 21 BP 9302 EP 9310 DI 10.1002/2015GL066389 PG 9 WC Geosciences, Multidisciplinary SC Geology GA DB2KK UT WOS:000368336800064 ER PT J AU Arun, P Oguntayo, S Van Albert, S Gist, I Wang, Y Nambiar, MP Long, JB AF Arun, Peethambaran Oguntayo, Samuel Van Albert, Stephen Gist, Irene Wang, Ying Nambiar, Madhusoodana P. Long, Joseph B. TI Acute decrease in alkaline phosphatase after brain injury: A potential mechanism for tauopathy SO NEUROSCIENCE LETTERS LA English DT Article DE Blast exposure; Head impact/acceleration; Tauopathy; Chronic traumatic encephalopathy; Traumatic brain injury; Tissue non-specific alkaline phosphatase ID AMYLOID PRECURSOR PROTEIN; TAU-PHOSPHORYLATION; BIOLOGICAL-ACTIVITY; BLAST OVERPRESSURE; ALZHEIMERS-DISEASE; BETA-APP; EXPRESSION; MODEL; MICE; EXPOSURE AB Dephosphorylation of phosphorylated Tau (pTau) protein, which is essential for the preservation of neuronal microtubule assemblies and for protection against trauma-induced tauopathy and chronic traumatic encephalopathy (CTE), is primarily achieved in brain by tissue non-specific alkaline phosphatase (TNAP). Paired helical filaments (PHFs) and Tau isolated from Alzheimer's disease (AD) patients' brains have been shown to form microtubule assemblies with tubulin only after treatment with TNAP or protein phosphatase-2A, 2B and -1, suggesting that Tau protein in the PHFs of neurons in AD brain is hyperphosphorylated, which prevents microtubule assembly. Using blast or weight drop models of traumatic brain injury (TBI) in rats, we observed pTau accumulation in the brain as early as 6 h post-injury and further accumulation which varied regionally by 24 h post-injury. The pTau accumulation was accompanied by reduced TNAP expression and activity in these brain regions and a significantly decreased plasma total alkaline phosphatase activity after the weight drop. These results reveal that both blast- and impact acceleration-induced head injuries cause an acute decrease in the level/activity of TNAP in the brain, which potentially contributes to trauma-induced accumulation of pTau and the resultant tauopathy. The regional changes in the level/activity of TNAP or accumulation of pTau after these injuries did not correlate with the accumulation of amyloid precursor protein, suggesting that the basic mechanism underlying tauopathy in TBI might be distinct from that associated with AD. (C) 2015 Elsevier Ireland Ltd. All rights reserved. C1 [Arun, Peethambaran; Oguntayo, Samuel; Van Albert, Stephen; Gist, Irene; Wang, Ying; Nambiar, Madhusoodana P.; Long, Joseph B.] Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Arun, P (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM peethambaran.arun.ctr@mail.mil; joseph.b.long.civ@mail.mil FU Congressionally Directed Medical Research Program [W81XWH-08-2-0018, W81XWH-11-2-0127] FX Technical help received from Rania Abu-Taleb, Andrea Edwards and Cory Riccio is greatly acknowledged. This work was supported by Congressionally Directed Medical Research Program awards W81XWH-08-2-0018 and W81XWH-11-2-0127 to JBL. NR 36 TC 0 Z9 0 U1 3 U2 5 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0304-3940 EI 1872-7972 J9 NEUROSCI LETT JI Neurosci. Lett. PD NOV 16 PY 2015 VL 609 BP 152 EP 158 DI 10.1016/j.neulet.2015.10.036 PG 7 WC Neurosciences SC Neurosciences & Neurology GA CZ0CK UT WOS:000366772500027 PM 26483321 ER PT J AU Moon, SY Wagner, GW Mondloch, JE Peterson, GW DeCoste, JB Hupp, JT Farha, OK AF Moon, Su-Young Wagner, George W. Mondloch, Joseph E. Peterson, Gregory W. DeCoste, Jared B. Hupp, Joseph T. Farha, Omar K. TI Effective, Facile, and Selective Hydrolysis of the Chemical Warfare Agent VX Using Zr-6-Based Metal-Organic Frameworks SO INORGANIC CHEMISTRY LA English DT Article ID DETOXIFICATION; DEGRADATION; STABILITY; HD; GD; PHOSPHOTRIESTERASE; PURIFICATION; DESTRUCTION; SIMULANTS AB The nerve agent VX is among the most toxic chemicals known to mankind, and robust solutions are needed to rapidly and selectively deactivate it. Herein, we demonstrate that three Zr-6-based metal organic frameworks (MOFs), namely, UiO-67, UiO-67-NH2, and UiO-67-N(Me)(2), are selective and highly active catalysts for the hydrolysis of VX. Utilizing UiO-67, UiO-67-NH2, and UiO-67-N(Me)(2) in a pH 10 buffered solution of Nethylmorpholine, selective hydrolysis of the P S bond in VX was observed. In addition, UiO-67-N(Me)(2) was found to catalyze VX hydrolysis with an initial half-life of 1.8 min. This half-life is nearly 3 orders of magnitude shorter than that of the only other MOF tested to date for hydrolysis of VX and rivals the activity of the best nonenzymatic materials. Hydrolysis utilizing Zr-based MOFs is also selective and facile in the absence of pH 10 buffer (just water) and for the destruction of the toxic byproduct EA-2192. C1 [Moon, Su-Young; Hupp, Joseph T.; Farha, Omar K.] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA. [Wagner, George W.; Peterson, Gregory W.; DeCoste, Jared B.] US Army, Edgewood Chem Biol Ctr, Res Dev & Engn Command, Aberdeen Proving Ground, MD 21010 USA. [Mondloch, Joseph E.] Univ Wisconsin, Dept Chem, Stevens Point, WI 54482 USA. [DeCoste, Jared B.] Leidos Inc, Gunpower, MD 21010 USA. [Farha, Omar K.] King Abdulaziz Univ, Fac Sci, Dept Chem, Jeddah 21413, Saudi Arabia. RP Farha, OK (reprint author), Northwestern Univ, Dept Chem, 2145 Sheridan Rd, Evanston, IL 60208 USA. EM o-farha@northwestern.edu RI Faculty of, Sciences, KAU/E-7305-2017 FU DTRA [HDTRA-1-10-0023]; Joint Science Technology Office for Chemical and Biological Defense (JSTO-CBD) [BA13PHM210] FX O.K.F. and J.T.H. gratefully acknowledge DTRA for financial support (Grant HDTRA-1-10-0023). G.W.W., G.W.P., and J.B.D. gratefully acknowledge the Joint Science Technology Office for Chemical and Biological Defense (JSTO-CBD) for financial support under Program BA13PHM210. We thank Mr. McGuirk for sharing the synthesis procedure that we used to synthesize some of the organic linkers. NR 48 TC 13 Z9 13 U1 34 U2 102 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0020-1669 EI 1520-510X J9 INORG CHEM JI Inorg. Chem. PD NOV 16 PY 2015 VL 54 IS 22 BP 10829 EP 10833 DI 10.1021/acs.inorgchem.5b01813 PG 5 WC Chemistry, Inorganic & Nuclear SC Chemistry GA CW4SB UT WOS:000364981300039 PM 26505999 ER PT J AU Khan, F Porter, M Schwenk, R DeBot, M Saudan, P Dutta, S AF Khan, Farhat Porter, Mike Schwenk, Robert DeBot, Margot Saudan, Philippe Dutta, Sheetij TI Head-to-Head Comparison of Soluble vs. Q beta VLP Circumsporozoite Protein Vaccines Reveals Selective Enhancement of NANP Repeat Responses SO PLOS ONE LA English DT Article ID VIRUS-LIKE PARTICLES; MEROZOITE SURFACE PROTEIN-1; PLASMODIUM-FALCIPARUM; ANTIBODY-RESPONSE; NEUTRALIZING ANTIBODY; IMMUNE-RESPONSE; MALARIA ANTIGEN; AOTUS-NANCYMAI; CELL EPITOPES; IN-VITRO AB Circumsporozoite protein (CSP) of Plasmodium falciparum is a promising malaria vaccine target. RTS, S, the most advanced malaria vaccine candidate consists of the central NANP repeat and carboxy-terminal region of CSP displayed on a hepatitis B virus-like particle (VLP). To build upon the success of RTS, S, we produced a near full-length Plasmodium falciparum CSP that also includes the conserved amino-terminal region of CSP. We recently showed that this soluble CSP, combined with a synthetic Toll-like-receptor-4 (TLR4) agonist in stable oil-in-water emulsion (GLA/SE), induces a potent and protective immune response in mice against transgenic parasite challenge. Here we have investigated whether the immunogenicity of soluble CSP could be further augmented by presentation on a VLP. Bacteriophage Q beta VLPs can be readily produced in E. coli, they have a diameter of 25 nm and contain packaged E. coli RNA which serves as a built in adjuvant through the activation of TLR7/8. CSP was chemically conjugated to Q beta and the CSP-Q beta vaccine immunogenicity and efficacy were compared to adjuvanted soluble CSP in the C57Bl/6 mouse model. When formulated with adjuvants lacking a TLR4 agonist (Alum, SE and Montanide) the Q beta-CSP induced higher anti-NANP repeat titers, higher levels of cytophilic IgG2b/c antibodies and a trend towards higher protection against transgenic parasite challenge as compared to soluble CSP formulated in the same adjuvant. The VLP and soluble CSP immunogenicity difference was most pronounced at low antigen dose, and within the CSP molecule, the titers against the NANP repeats were preferentially enhanced by Q beta presentation. While a TLR4 agonist enhanced the immunogenicity of soluble CSP to levels comparable to the VLP vaccine, the TLR4 agonist did not further improve the immunogenicity of the Q beta-CSP vaccine. The data presented here pave the way for further improvement in the Q beta conjugation chemistry and evaluation of both the Q beta-CSP and soluble CSP vaccines in the non-human primate model. C1 [Khan, Farhat; Porter, Mike; Schwenk, Robert; DeBot, Margot; Dutta, Sheetij] Walter Reed Army Inst Res, Struct Vaccinol Lab, Malaria Vaccine Branch, Silver Spring, MD 20910 USA. [Saudan, Philippe] Cytos Biotechnol, CH-8952 Schlieren, Switzerland. RP Dutta, S (reprint author), Walter Reed Army Inst Res, Struct Vaccinol Lab, Malaria Vaccine Branch, Silver Spring, MD 20910 USA. EM Sheetij.dutta.civ@mail.mil FU USAID; Bill and Melinda Gates Foundation [42387] FX USAID provided financial support in the form of salary for authors FK, MP, RS, MD but USAID did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the "author contributions" section.; We thank Mala Dutta, Tim Phares and Norman Waters for critical review of the manuscript. We are grateful to Randy Howard and Infectious Disease Research Institute for the adjuvant GLA/SE, which was provided under grant#42387 from the Bill and Melinda Gates Foundation. We thank Roberta Spaccapelo and Andrea Crisanti for the transgenic CSP P. berghei parasite. We acknowledge Meng Shi for help with the statistical analysis. We also thank Chris Ockenhouse, Lorraine Soisson and Carter Diggs for their advice. Funding for this work was provided by USAID. We thank Ted Hall for the humanized monoclonal antibodies against CSP. Disclaimer: SD is a US Government employee. The work of this individual was prepared as part of official government duties. The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Army, the Department of Defense, or the U.S. Government. NR 57 TC 1 Z9 1 U1 1 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 16 PY 2015 VL 10 IS 11 AR e0142035 DI 10.1371/journal.pone.0142035 PG 18 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CW5XP UT WOS:000365070700016 PM 26571021 ER PT J AU Verma, G Chan, K Swami, A AF Verma, Gunjan Chan, Kevin Swami, Ananthram TI Zealotry promotes coexistence in the rock-paper-scissors model of cyclic dominance SO PHYSICAL REVIEW E LA English DT Article ID MULTIPLE STRATEGIES; DYNAMICS; GAME; BIODIVERSITY; LIZARD AB Cyclic dominance models, such as the classic rock-paper-scissors (RPS) game, have found real-world applications in biology, ecology, and sociology. A key quantity of interest in such models is the coexistence time, i.e., the time until at least one population type goes extinct. Much recent research has considered conditions that lengthen coexistence times in an RPS model. A general finding is that coexistence is promoted by localized spatial interactions (low mobility), while extinction is fostered by global interactions (high mobility). That is, there exists a mobility threshold which separates a regime of long coexistence from a regime of rapid collapse of coexistence. The key finding of our paper is that if zealots (i.e., nodes able to defeat others while themselves being immune to defeat) of even a single type exist, then system coexistence time can be significantly prolonged, even in the presence of global interactions. This work thus highlights a crucial determinant of system survival time in cyclic dominance models. C1 [Verma, Gunjan; Chan, Kevin; Swami, Ananthram] Army Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA. RP Verma, G (reprint author), Army Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA. EM gunjan.verma.civ@mail.mil; kevin.s.chan.civ@mail.mil; ananthram.swami.civ@mail.mil NR 31 TC 2 Z9 2 U1 0 U2 4 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1539-3755 EI 1550-2376 J9 PHYS REV E JI Phys. Rev. E PD NOV 16 PY 2015 VL 92 IS 5 AR 052807 DI 10.1103/PhysRevE.92.052807 PG 10 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA CW3QC UT WOS:000364905800008 PM 26651744 ER PT J AU Kalambate, PK Biradar, MR Karna, SP Srivastava, AK AF Kalambate, Pramod K. Biradar, Madan R. Karna, Shashi P. Srivastava, Ashwini K. TI Adsorptive stripping differential pulse voltammetry determination of rivastigmine at graphene nanosheet-gold nanoparticle/carbon paste electrode SO JOURNAL OF ELECTROANALYTICAL CHEMISTRY LA English DT Article DE Rivastigmine; Graphene; Gold nanoparticles; Adsorptive stripping voltammetry ID TANDEM MASS-SPECTROMETRY; GLASSY-CARBON ELECTRODE; LIQUID-CHROMATOGRAPHY; COPPER(II) COMPLEX; BIOMIMETIC SENSOR; HYDROGEN TARTRATE; HUMAN PLASMA; OXIDE; ACID; DEGRADATION AB The study of graphene nanosheet (GNS) -gold nanoparticle (AuNP)-carbon paste electrode (GNS-AuNP-CPE) as an electrochemical sensor for the determination of rivastigmine (RIV) in pharmaceuticals formulations, blood serum, and urine samples is presented. The GNS-AuNP composite is prepared by in situ simultaneous reduction of graphene oxide and chloroauric acid using sodium borohydride as a reducing agent. The GNS-AuNP composite was characterized by X-ray diffraction, UV-Vis spectroscopy, and scanning electron microscopy. Electrochemical characterization of the GNS-AuNP-CPE electrode surface was carried out by cyclic voltammetry, electrochemical impedance spectroscopy, chronocoulometry, and adsorptive stripping differential pulse voltammetiy. This study shows that oxidation of rivastigmine is facilitated at the GNS-AuNP-CPE electrode and remarkably increase in current compared to the bare electrode due to enhanced adsorption of the former on electrode surface. Under the optimized conditions, the peak current (I-p) is found to be proportional to the RIV concentration in the range of 2.0 x 10(-7)-6.0 x 10(-4) M with a detection limit of 5.3 x 10(-8) M. The proposed sensor shows a very high level of sensitivity, selectivity, and a very good reproducibility for RIV determination. A good recovery level obtained for real samples suggests practical utility of the GNS-AuNP-CPE as an effective and reliable electrochemical sensor for RIV detection. (C) 2015 Elsevier B.V. All rights reserved. C1 [Kalambate, Pramod K.; Biradar, Madan R.; Srivastava, Ashwini K.] Univ Bombay, Dept Chem, Bombay 400098, Maharashtra, India. [Karna, Shashi P.] US Army Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA. RP Srivastava, AK (reprint author), Univ Bombay, Dept Chem, Bombay 400098, Maharashtra, India. EM aksrivastava@chem.mu.ac.in FU University Grant Commission, New Delhi, India; US Army International Technology Center, Tokyo, Japan [FA5209-09-P-02] FX The funding for this work is by the University Grant Commission, New Delhi, India under the University with potential for excellence scheme to University of Mumbai and partly by the US Army International Technology Center, Tokyo, Japan through grant number FA5209-09-P-02. NR 37 TC 2 Z9 2 U1 4 U2 24 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 1572-6657 EI 1873-2569 J9 J ELECTROANAL CHEM JI J. Electroanal. Chem. PD NOV 15 PY 2015 VL 757 BP 150 EP 158 DI 10.1016/j.jelechem.2015.09.027 PG 9 WC Chemistry, Analytical; Electrochemistry SC Chemistry; Electrochemistry GA CY2JA UT WOS:000366233600021 ER PT J AU Audet, GN Quinn, CM Leon, LR AF Audet, Gerald N. Quinn, Carrie M. Leon, Lisa R. TI Point-of-care cardiac troponin test accurately predicts heat stroke severity in rats SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY LA English DT Article DE field test; heat stroke; cardiac troponin; point of care; rat ID ACUTE MYOCARDIAL-INFARCTION; CHEST-PAIN PATIENTS; CREATINE-KINASE MB; TIME-COURSE; PROGNOSTIC VALUE; DIAGNOSIS; INJURY; HEATSTROKE; ELEVATION; MYOGLOBIN AB Heat stroke (HS) remains a significant public health concern. Despite the substantial threat posed by HS, there is still no field or clinical test of HS severity. We suggested previously that circulating cardiac troponin (cTnI) could serve as a robust biomarker of HS severity after heating. In the present study, we hypothesized that (cTnI) point-of-care test (ctPOC) could be used to predict severity and organ damage at the onset of HS. Conscious male Fischer 344 rats (n = 16) continuously monitored for heart rate (HR), blood pressure (BP), and core temperature (T-c) (radiotelemetry) were heated to maximum T-c (T-c,T-Max) of 41.9 +/- 0.1 degrees C and recovered undisturbed for 24 h at an ambient temperature of 20 degrees C. Blood samples were taken at T-c,T-Max and 24 h after heat via submandibular bleed and analyzed on ctPOC test. POC cTnI band intensity was ranked using a simple four-point scale via two blinded observers and compared with cTnI levels measured by a clinical blood analyzer. Blood was also analyzed for biomarkers of systemic organ damage. HS severity, as previously defined using HR, BP, and recovery Tc profile during heat exposure, correlated strongly with cTnI (R-2 = 0.69) at T-c,T-Max. POC cTnI band intensity ranking accurately predicted cTnI levels (R-2 = 0.64) and HS severity (R-2 = 0.83). Five markers of systemic organ damage also correlated with ctPOC score (albumin, alanine aminotransferase, blood urea nitrogen, cholesterol, and total bilirubin; R-2 > 0.4). This suggests that cTnI POC tests can accurately determine HS severity and could serve as simple, portable, cost-effective HS field tests. C1 [Audet, Gerald N.; Quinn, Carrie M.; Leon, Lisa R.] US Army, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Audet, GN (reprint author), US Army, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St,Bldg 42, Natick, MA 01760 USA. EM Gerald.n.audet.ctr@mail.mil FU Military Operational Medicine Research Program, USAMRMC, MD FX This research was supported by the Military Operational Medicine Research Program, USAMRMC, MD and by an appointment to the Postgraduate Research Participation Program at the U.S. Army Medical Research Institute of Environmental Medicine administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USAMRMC. NR 63 TC 0 Z9 0 U1 1 U2 4 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0363-6119 EI 1522-1490 J9 AM J PHYSIOL-REG I JI Am. J. Physiol.-Regul. Integr. Comp. Physiol. PD NOV 15 PY 2015 VL 309 IS 10 BP R1264 EP R1272 DI 10.1152/ajpregu.00286.2015 PG 9 WC Physiology SC Physiology GA CX7JT UT WOS:000365878700008 PM 26290107 ER PT J AU Ndhlovu, LC D'Antoni, ML Ananworanich, J Byron, MM Chalermchai, T Sithinamsuwan, P Tipsuk, S Ho, E Slike, BM Schuetz, A Zhang, GX Agsalda-Garcia, M Shiramizu, B Shikuma, CM Valcour, V AF Ndhlovu, Lishomwa C. D'Antoni, Michelle L. Ananworanich, Jintanat Byron, Mary Margaret Chalermchai, Thep Sithinamsuwan, Pasiri Tipsuk, Somporn Ho, Erika Slike, Bonnie M. Schuetz, Alexandra Zhang, Guangxiang Agsalda-Garcia, Melissa Shiramizu, Bruce Shikuma, Cecilia M. Valcour, Victor TI Loss of CCR2 expressing non-classical monocytes are associated with cognitive impairment in antiretroviral therapy-naive HIV-infected Thais SO JOURNAL OF NEUROIMMUNOLOGY LA English DT Article DE HIV-associated neurocognitive disorders (HAND); Monocytes; C-C chemokine receptor (CCR) CCR2; CD163; Neopterin ID CEREBROSPINAL-FLUID NEOPTERIN; AIDS DEMENTIA; NEUROCOGNITIVE IMPAIRMENT; IMMUNE ACTIVATION; RNA; BIOMARKERS; DISORDERS; PROTEIN-1; NEUROAIDS; ELEVATION AB HIV DNA in monocytes has been linked to HIV-associated neurocognitive disorders (HAND), however, characterization of monocyte subsets associated with HAND remains unclear. We completed a prospective study of antiretroviral therapy-naive, MN-infected Thais, with varying degrees of cognitive impairment, compared to HIV-uninfected controls. Monocyte subsets' CCR2, CCR5 and CD163 expression were profiled and inflammatory markers in plasma and cerebrospinal fluid (CSF), measured. Lower numbers of CCR2(+) non-classical monocytes were associated with worse neuropsychological test performance (r = 0.43, p = 0.024). CCR2(+) non-classical monocyte count inversely correlated with CSF neopterin (r = 0.43, p = 0.035) and plasma TNF-alpha. levels (r = 0.40, p = 0.041). These data benchmark CCR2+non-classical monocytes as an independent index of cognitive impairment. (C) 2015 Elsevier B.V. All rights reserved. C1 [Ndhlovu, Lishomwa C.; D'Antoni, Michelle L.; Byron, Mary Margaret; Ho, Erika; Agsalda-Garcia, Melissa; Shiramizu, Bruce; Shikuma, Cecilia M.] Univ Hawaii, Hawaii Ctr AIDS, John A Burns Sch Med, Honolulu, HI 96813 USA. [Ndhlovu, Lishomwa C.; D'Antoni, Michelle L.; Byron, Mary Margaret; Chalermchai, Thep; Tipsuk, Somporn; Zhang, Guangxiang; Agsalda-Garcia, Melissa; Shiramizu, Bruce] Univ Hawaii, John A Burns Sch Med, Dept Trop Med Med Microbiol & Pharmacol, Honolulu, HI 96813 USA. [Zhang, Guangxiang] Univ Hawaii, John A Burns Sch Med, Biostat & Data Management Core, Honolulu, HI 96813 USA. [Ananworanich, Jintanat] SEARCH, Bangkok, Thailand. [Sithinamsuwan, Pasiri] Thai Red Cross AIDS Res Ctr, Bangkok, Thailand. [Ananworanich, Jintanat; Slike, Bonnie M.; Schuetz, Alexandra] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Schuetz, Alexandra] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Valcour, Victor] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA. [Slike, Bonnie M.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. RP Ndhlovu, LC (reprint author), Univ Hawaii, Hawaii Ctr AIDS, Dept Trop Med, 651 Halo St, Honolulu, HI 96813 USA. EM lndhlovu@hawaii.edu; dantonim@hawaii.edu; jananworanich@hivresearch.org; marymp@hawaii.edu; thep.c@searchthailand.org; pasiripmk@gmail.com; somporn.t@searchthailand.org; eho6@hawaii.edu; bslike@hivresearch.org; Alexandra.Schuetz.ctr@afrims.org; gzhang8@hawaii.edu; magsalda@hawaii.edu; bshirami@hawaii.edu; shikuma@hawaii.edu; vvalcour@memory.ucsf.eduthe FU National Institute of Neurological Disorders and Stroke of the National Institutes of Health (NIH) [R01NS061696]; NIH/NIMHD [U54MD007584, G12MD007601, P20GM103466] FX We thank the SEARCH 011 participants and the SEARCH 011 study group. The SEARCH 011 study group includes: from SEARCH/TRCARC: Nittaya Phanuphak, Nitiya Chomchey, Eugene Kroon, Donn Colby, James Fletcher, Duanghathai Sutthichom, Somprartthana Rattanamanee, Peeriya Mangyu, Sasiwimol Ubolyam, Pacharin Eamyoung, Suwanna Puttamaswin and Putthachard Sangtawan; from Chulalongkorn University: Sukalya Lerdlum, Mantana Pothisri, Nijasri Charnnarong; from Phramongkutklao Medical Center: Yotin Chinvarun; from the Armed Forces Research Institute of Medical Sciences: Rapee Trichavaroj, Siriwat Akapirat, Weerawan Chuenarom, Boot Keawboon; from Taksin Hospital: Supunee Jirajariyavej. Akash Desai, Nicholas Huntchings, Lauren Wendelken and Katherine Clifford (UCSF). Research reported in this publication was supported by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health (NIH) under Award Number R01NS061696. This work was also supported in part by NIH/NIMHD grant U54MD007584, G12MD007601 and P20GM103466. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. NR 43 TC 3 Z9 3 U1 2 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-5728 EI 1872-8421 J9 J NEUROIMMUNOL JI J. Neuroimmunol. PD NOV 15 PY 2015 VL 288 BP 25 EP 33 DI 10.1016/j.jneuroim.2015.08.020 PG 9 WC Immunology; Neurosciences SC Immunology; Neurosciences & Neurology GA CW5PV UT WOS:000365049800004 PM 26531691 ER PT J AU Amyot, F Arciniegas, DB Brazaitis, MP Curley, KC Diaz-Arrastia, R Gandjbakhche, A Herscovitch, P Hinds, SR Manley, GT Pacifico, A Razumovsky, A Riley, J Salzer, W Shih, R Smirniotopoulos, JG Stocker, D AF Amyot, Franck Arciniegas, David B. Brazaitis, Michael P. Curley, Kenneth C. Diaz-Arrastia, Ramon Gandjbakhche, Amir Herscovitch, Peter Hinds, Sidney R., II Manley, Geoffrey T. Pacifico, Anthony Razumovsky, Alexander Riley, Jason Salzer, Wanda Shih, Robert Smirniotopoulos, James G. Stocker, Derek TI A Review of the Effectiveness of Neuroimaging Modalities for the Detection of Traumatic Brain Injury SO JOURNAL OF NEUROTRAUMA LA English DT Review DE electrophysiology; imaging; spectroscopy; tomography; ultrasound ID POSITRON-EMISSION-TOMOGRAPHY; TRANSCRANIAL DOPPLER ULTRASONOGRAPHY; DIFFUSE AXONAL INJURY; CEREBRAL-BLOOD-FLOW; MINOR HEAD-INJURY; ANEURYSMAL SUBARACHNOID HEMORRHAGE; NEAR-INFRARED SPECTROSCOPY; POSTTRAUMATIC-STRESS-DISORDER; EVENT-RELATED POTENTIALS; OPERATION IRAQI FREEDOM AB The incidence of traumatic brain injury (TBI) in the United States was 3.5 million cases in 2009, according to the Centers for Disease Control and Prevention. It is a contributing factor in 30.5% of injury-related deaths among civilians. Additionally, since 2000, more than 260,000 service members were diagnosed with TBI, with the vast majority classified as mild or concussive (76%). The objective assessment of TBI via imaging is a critical research gap, both in the military and civilian communities. In 2011, the Department of Defense (DoD) prepared a congressional report summarizing the effectiveness of seven neuroimaging modalities (computed tomography [CT], magnetic resonance imaging [MRI], transcranial Doppler [TCD], positron emission tomography, single photon emission computed tomography, electrophysiologic techniques [magnetoencephalography and electroencephalography], and functional near-infrared spectroscopy) to assess the spectrum of TBI from concussion to coma. For this report, neuroimaging experts identified the most relevant peer-reviewed publications and assessed the quality of the literature for each of these imaging technique in the clinical and research settings. Although CT, MRI, and TCD were determined to be the most useful modalities in the clinical setting, no single imaging modality proved sufficient for all patients due to the heterogeneity of TBI. All imaging modalities reviewed demonstrated the potential to emerge as part of future clinical care. This paper describes and updates the results of the DoD report and also expands on the use of angiography in patients with TBI. C1 [Amyot, Franck; Gandjbakhche, Amir] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Bethesda, MD USA. [Amyot, Franck; Diaz-Arrastia, Ramon] Uniformed Serv Univ Hlth Sci, Ctr Neurosci & Regenerat Med, Bethesda, MD 20814 USA. [Smirniotopoulos, James G.] Uniformed Serv Univ Hlth Sci, Dept Radiol Neurol & Biomed Informat, Bethesda, MD 20814 USA. [Arciniegas, David B.] Baylor Coll Med, Beth K & Stuart C Yudofsky Div Neuropsychiat, Houston, TX 77030 USA. [Arciniegas, David B.] TIRR Mem Hermann, Brain Injury Res, Houston, TX USA. [Brazaitis, Michael P.] US States Army, Washington, DC USA. [Brazaitis, Michael P.] Geneva Fdn, Geneva, Switzerland. [Curley, Kenneth C.] US Army Med Res & Mat Command, Combat Casualty Care Directorate RAD2, Ft Detrick, MD USA. [Herscovitch, Peter] Natl Inst Hlth Clin Ctr, Positron Emiss Tomog Dept, Bethesda, MD USA. [Hinds, Sidney R., II] Def Ctr Excellence Psychol Hlth & Traumat Brain I, Def & Vet Brain Injury Ctr, Silver Spring, MD USA. [Manley, Geoffrey T.] Univ Calif San Francisco, Dept Neurol Surg, Brain & Spinal Injury Ctr, San Francisco, CA USA. [Pacifico, Anthony; Salzer, Wanda] MCMR CD, Congress Directed Med Res Programs, Ft Detrick, MD 21702 USA. [Razumovsky, Alexander] Sentient NeuroCare Serv Inc, Hunt Valley, MD USA. [Riley, Jason] Queens Univ, Kingston, ON, Canada. [Riley, Jason] ArcheOptix Inc, Picton, ON, Canada. [Shih, Robert; Stocker, Derek] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. RP Pacifico, A (reprint author), MCMR CD, Congress Directed Med Res Programs, 1077 Patchel St, Ft Detrick, MD 21702 USA. EM anthony.m.pacifico.civ@mail.mil FU ArcheOptix Inc., a biomedical devices company FX Alexander Razumovsky is a full time employee of Sentient Medical Systems, a for-profit company providing medical monitoring and diagnostic services. Jason Riley is partially funded and employed by ArcheOptix Inc., a biomedical devices company. For the remaining authors, no competing financial interests exist. NR 350 TC 7 Z9 7 U1 8 U2 28 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD NOV 15 PY 2015 VL 32 IS 22 BP 1693 EP 1721 DI 10.1089/neu.2013.3306 PG 29 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA CV6ST UT WOS:000364401500001 PM 26176603 ER PT J AU Smith, DH Hicks, RR Johnson, VE Bergstrom, DA Cummings, DM Noble, LJ Hovda, D Whalen, M Ahlers, ST LaPlaca, M Tortella, FC Duhaime, AC Dixon, CE AF Smith, Douglas H. Hicks, Ramona R. Johnson, Victoria E. Bergstrom, Debra A. Cummings, Diana M. Noble, Linda J. Hovda, David Whalen, Michael Ahlers, Stephen T. LaPlaca, Michelle Tortella, Frank C. Duhaime, Ann-Christine Dixon, C. Edward TI Pre-Clinical Traumatic Brain Injury Common Data Elements: Toward a Common Language Across Laboratories SO JOURNAL OF NEUROTRAUMA LA English DT Article DE common data elements; data dictionary; pre-clinical TBI models; traumatic brain injury ID DIFFUSE AXONAL INJURY; CONTROLLED CORTICAL IMPACT; CLOSED-HEAD-INJURY; CEREBRAL BLOOD-FLOW; ACUTE SUBDURAL-HEMATOMA; ADULT-RAT BRAIN; FLUID-PERCUSSION MODEL; LASTING IMPULSE NOISE; ALZHEIMERS-DISEASE; INTRACRANIAL-PRESSURE AB Traumatic brain injury (TBI) is a major public health issue exacting a substantial personal and economic burden globally. With the advent of big data approaches to understanding complex systems, there is the potential to greatly accelerate knowledge about mechanisms of injury and how to detect and modify them to improve patient outcomes. High quality, well-defined data are critical to the success of bioinformatics platforms, and a data dictionary of common data elements (CDEs), as well as unique data elements has been created for clinical TBI research. There is no data dictionary, however, for preclinical TBI research despite similar opportunities to accelerate knowledge. To address this gap, a committee of experts was tasked with creating a defined set of data elements to further collaboration across laboratories and enable the merging of data for meta-analysis. The CDEs were subdivided into a Core module for data elements relevant to most, if not all, studies, and Injury-Model-Specific modules for non-generalizable data elements. The purpose of this article is to provide both an overview of TBI models and the CDEs pertinent to these models to facilitate a common language for preclinical TBI research. C1 [Smith, Douglas H.; Johnson, Victoria E.] Univ Penn, Dept Neurosurg, Philadelphia, PA 19104 USA. [Hicks, Ramona R.] One Mind, Seattle, WA USA. [Hicks, Ramona R.; Bergstrom, Debra A.; Cummings, Diana M.] NINDS, NIH, Bethesda, MD 20892 USA. [Noble, Linda J.] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA USA. [Hovda, David] Univ Calif Los Angeles, Dept Neurosurg, Los Angeles, CA USA. [Whalen, Michael] Massachusetts Gen Hosp, Dept Pediat, Ctr Neurosci, Charlestown, MA USA. [Ahlers, Stephen T.] Naval Med Res Ctr, Operat & Undersea Med Directorate, Silver Spring, MD USA. [LaPlaca, Michelle] Georgia Tech, Dept Biomed Engn, Atlanta, GA USA. [LaPlaca, Michelle] Emory Univ, Atlanta, GA 30322 USA. [Tortella, Frank C.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Duhaime, Ann-Christine] Harvard Univ, Sch Med, Dept Neurosurg, Boston, MA USA. [Dixon, C. Edward] Univ Pittsburgh, Dept Neurol Surg, Pittsburgh, PA 15260 USA. RP Smith, DH (reprint author), Univ Penn, Dept Neurosurg, 105 Hayden Hall,3320 Smith Walk, Philadelphia, PA 19104 USA. EM smithdou@mail.med.upenn.edu FU U.S. Department of Defense; National Institutes of Health FX We would like to acknowledge the U.S. Department of Defense and the National Institutes of Health who contributed funding for The Federal Interagency Traumatic Brain Injury Research (FIT-BIR) Informatics System. NR 131 TC 11 Z9 11 U1 2 U2 5 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD NOV 15 PY 2015 VL 32 IS 22 BP 1725 EP 1735 DI 10.1089/neu.2014.3861 PG 11 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA CV6ST UT WOS:000364401500003 PM 26058402 ER PT J AU Burgess, E AF Burgess, Edwin TI The Longest Kill: The Story of Maverick 41, One of the World's Greatest Snipers SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] US Army Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. RP Burgess, E (reprint author), US Army Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 2 U2 2 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD NOV 15 PY 2015 VL 140 IS 19 BP 92 EP 92 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA CW2EH UT WOS:000364803400164 ER PT J AU Dong, L Wang, J Namburu, R O'Regan, TP Dubey, M Dongare, AM AF Dong, Liang Wang, Jin Namburu, Raju O'Regan, Terrance P. Dubey, Madan Dongare, Avinash M. TI Edge effects on band gap energy in bilayer 2H-MoS2 under uniaxial strain SO JOURNAL OF APPLIED PHYSICS LA English DT Correction C1 [Dong, Liang; Wang, Jin; Dongare, Avinash M.] Univ Connecticut, Dept Mat Sci & Engn, Storrs, CT 06269 USA. [Dong, Liang; Wang, Jin; Dongare, Avinash M.] Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA. [Namburu, Raju] US Army, Res Lab, Computat & Informat Sci Directorate, Aberdeen Proving Ground, MD 21005 USA. [O'Regan, Terrance P.; Dubey, Madan] US Army, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Dongare, AM (reprint author), Univ Connecticut, Dept Mat Sci & Engn, Storrs, CT 06269 USA. EM dongare@uconn.edu NR 2 TC 0 Z9 0 U1 3 U2 17 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD NOV 14 PY 2015 VL 118 IS 18 AR 189904 DI 10.1063/1.4935944 PG 1 WC Physics, Applied SC Physics GA CW5NF UT WOS:000365041700057 ER PT J AU Slaby, I Holmes, A Moran, JM Eddy, MD Mahoney, CR Taylor, HA Brunye, TT AF Slaby, Isabella Holmes, Amanda Moran, Joseph M. Eddy, Marianna D. Mahoney, Caroline R. Taylor, Holly A. Brunye, Tad T. TI Direct current stimulation of the left temporoparietal junction modulates dynamic humor appreciation SO NEUROREPORT LA English DT Article DE direct current stimulation; humor; neuromodulation; theory of mind ID CURRENT BRAIN-STIMULATION; INDIVIDUAL-DIFFERENCES; SOCIAL COGNITION; TDCS; EFFICIENCY; HUMANS AB The aim of this study was to evaluate the influence of transcranial direct current stimulation targeting the left temporoparietal junction (TPJ) on humor appreciation during a dynamic video rating task. In a within-participants design, we targeted the left TPJ with anodal, cathodal, or no transcranial direct current stimulation, centered at electrode site C3 using a 4x1 targeted stimulation montage. During stimulation, participants dynamically rated a series of six stand-up comedy videos for perceived humor. We measured event-related (time-locked to crowd laughter) modulation of humor ratings as a function of stimulation condition. Results showed decreases in rated humor during anodal (vs. cathodal or none) stimulation; this pattern was evident for the majority of videos and was only partially predicted by individual differences in humor style. We discuss the possibility that upregulation of neural circuits involved in the theory of mind and empathizing with others may reduce appreciation of aggressive humor. In conclusion, the present data show that neuromodulation of the TPJ can alter the mental processes underlying humor appreciation, suggesting critical involvement of this cortical region in detecting, comprehending, and appreciating humor. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved. C1 [Taylor, Holly A.; Brunye, Tad T.] Tufts Univ, Ctr Appl Brain & Cognit Sci, Medford, MA 02155 USA. [Slaby, Isabella; Holmes, Amanda; Moran, Joseph M.; Eddy, Marianna D.; Mahoney, Caroline R.; Taylor, Holly A.; Brunye, Tad T.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA. [Holmes, Amanda; Moran, Joseph M.; Eddy, Marianna D.; Mahoney, Caroline R.; Brunye, Tad T.] US Army, Cognit Sci, Natick Soldier RDEC, Natick, MA USA. RP Brunye, TT (reprint author), Tufts Univ, Ctr Appl Brain & Cognit Sci, 200 Boston Ave,Suite 3000, Medford, MA 02155 USA. EM tbruny01@tufts.edu NR 25 TC 1 Z9 1 U1 1 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0959-4965 EI 1473-558X J9 NEUROREPORT JI Neuroreport PD NOV 11 PY 2015 VL 26 IS 16 BP 988 EP 993 DI 10.1097/WNR.0000000000000456 PG 6 WC Neurosciences SC Neurosciences & Neurology GA DA1EX UT WOS:000367540200008 PM 26351965 ER PT J AU Hofmeister, C Klimov, M Deleghanty, T Cho, K Sohn, Y AF Hofmeister, Clara Klimov, Mikhail Deleghanty, Tim Cho, Kyu Sohn, Yongho TI Quantification of nitrogen impurity and estimated Orowan strengthening through secondary ion mass spectroscopy in aluminum cryomilled for extended durations SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Aluminum alloy; Cryomilling; Nitrogen; Orowan strengthening; Secondary ion mass spectrometry ID NANOSTRUCTURED MATERIALS; COMPOSITE AB The strength of aluminum alloys and composites processed through powder metallurgy can be improved through the addition of nano-scale dispersoids introduced during the cryomilling process. Quantification of Orowan strengthening from these dispersoids requires a reliable measurement of the impurity concentration. Secondary ion mass spectrometry (SIMS) was used to quantify the nitrogen impurity concentration using a N-14 ion implanted standard. An analytical approach is devised to determine the nitrogen concentration of an aluminum alloy and composite based on SIMS measurements. Results are compared to the measurements carried out by gas fusion analysis. An increase in nitrogen concentration was observed with an increase in cryomilling time up to 72 h. The nitrogen concentration varied from 1.64 +/- 0.17 at% (0.80 +/- 0.08 wt%) to 19.12 +/- 1.10 at% (13.17 +/- 0.71 wt%) for the 8 h and 72 h cryomilled nanocrystalline AA5083, respectively. Assuming that all nitrogen reacts to form dispersoids, the nitrogen concentration determined was used to calculate the volume and weight fractions of dispersoids, which in turn was used to estimate the strengthening contribution via Orowan strengthening. Orowan strengthening was calculated using dispersoids of 3, 9 and 15 nm. The range of Orowan strengthening contribution was estimated, in MPa, to be from 7.69 +/- 0.78 to 3.03 +/- 031 for the 8 h nanocrystalline AA5083 sample, and 154.97 +/- 10.29 to 61.09 +/- 4.06 for the 72 h nanocrystalline AA5083 sample. (C) 2015 Elsevier B.V. All rights reserved. C1 [Hofmeister, Clara; Klimov, Mikhail; Sohn, Yongho] Univ Cent Florida, Dept Mat Sci & Engn, Adv Mat Proc & Anal Ctr, Orlando, FL 32816 USA. [Deleghanty, Tim] Pittsburgh Mat Technol, Jefferson Hills, PA 15025 USA. [Cho, Kyu] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Sohn, Y (reprint author), Univ Cent Florida, Dept Mat Sci & Engn, Adv Mat Proc & Anal Ctr, Orlando, FL 32816 USA. EM Yongho.sohn@ucf.edu RI Sohn, Yongho/A-8517-2010 OI Sohn, Yongho/0000-0003-3723-4743 FU U.S. Army Research Laboratory [W911NF-08-2-0026] FX The use of the Materials Characterization Facility at University of Central Michigan is gratefully acknowledged. The ion-implanted standard was graciously provided by Dr. Fabian Naab from the University of Michigan. The content of this paper is part of a thesis submitted by C. Hofmeister to the University of Central Florida in partial fulfillment of the requirements for the M.S. degree in Materials Science and Engineering. This research was sponsored by the U.S. Army Research Laboratory and was accomplished under Cooperative Agreement W911NF-08-2-0026. The views, opinions, and conclusions made in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 21 TC 2 Z9 2 U1 3 U2 9 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 EI 1873-4936 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD NOV 11 PY 2015 VL 648 BP 412 EP 417 DI 10.1016/j.msea.2015.09.007 PG 6 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA CU8UX UT WOS:000363820700051 ER PT J AU Valcour, VG Spudich, SS Sailasuta, N Phanuphak, N Lerdlum, S Fletcher, JLK Kroon, EDMB Jagodzinskr, LL Allen, IE Adams, CL Prueksakaew, P Slike, BM Hellmuth, JM Kim, JH Ananworanich, J AF Valcour, Victor G. Spudich, Serena S. Sailasuta, Napapon Phanuphak, Nittaya Lerdlum, Sukalaya Fletcher, James L. K. Kroon, Eugene D. M. B. Jagodzinskr, Linda L. Allen, Isabel E. Adams, Collin L. Prueksakaew, Peeriya Slike, Bonnie M. Hellmuth, Joanna M. Kim, Jerome H. Ananworanich, Jintanat CA SEARCH 010-RV 254 Study Grp TI Neurological Response to cART vs. cART plus Integrase Inhibitor and CCR5 Antagonist Initiated during Acute HIV SO PLoS One LA English DT Article ID CEREBROSPINAL-FLUID; TREATMENT INTENSIFICATION; INFECTION; RALTEGRAVIR; MARAVIROC; REPLICATION; PERFORMANCE; ABNORMALITIES; MONOCYTES; DYNAMICS AB Objective To compare central nervous system (CNS) outcomes in participants treated during acute HIV infection with standard combination antiretroviral therapy (cART) vs. cART plus integrase inhibitor and CCR5 antagonist (cART+). Design 24-week randomized open-label prospective evaluation. Method Participants were evaluated then randomized to initiate cART (efavirenz, tenofovir, and either emtricitabine or lamivudine) vs. cART+ (cART plus raltegravir and maraviroc) during acute HIV and re-evaluated at 4, 12 and 24 weeks. We examined plasma and CSF cytokines, HIV RNA levels, neurological and neuropsychological findings, and brain MRS across groups and compared to healthy controls. Results At baseline, 62 participants were in Fiebig stages I-V. Randomized groups were similar for mean age (27 vs. 25, p = 0.137), gender (each 94% male), plasma log(10) HIV RNA (5.4 vs. 5.6, p = 0.382), CSF log(10) HIV RNA (2.35 vs. 3.31, p = 0.561), and estimated duration of HIV (18 vs. 17 days, p = 0.546). Randomized arms did not differ at 24 weeks by any CNS outcome. Combining arms, all measures concurrent with antiretroviral treatment improved, for example, neuropsychological testing (mean NPZ-4 of -0.408 vs. 0.245, p<0.001) and inflammatory markers by MRS (e.g. mean frontal white matter (FWM) choline of 2.92 vs. 2.84, p = 0.045) at baseline and week 24, respectively. Plasma neopterin (p<0.001) and interferon gamma-induced protein 10 (IP-10) (p = 0.007) remained elevated in participants compared to controls but no statistically significant differences were seen in CSF cytokines compared to controls, despite individual variability among the HIV-infected group. Conclusions A 24-week course of cART+ improved CNS related outcomes, but was not associated with measurable differences compared to standard cART. C1 [Valcour, Victor G.; Adams, Collin L.; Hellmuth, Joanna M.] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA. [Spudich, Serena S.] Yale Univ, Dept Neurol, New Haven, CT USA. [Sailasuta, Napapon] Huntington Med Res Inst, Pasadena, CA USA. [Phanuphak, Nittaya; Fletcher, James L. K.; Kroon, Eugene D. M. B.; Prueksakaew, Peeriya; SEARCH 010-RV 254 Study Grp] Thai Red Cross AIDS Res Ctr, South East Asia Res Collaborat Hawaii, Bangkok, Thailand. [Lerdlum, Sukalaya; Ananworanich, Jintanat] Chulalongkorn Univ, Fac Med, Bangkok 10330, Thailand. [Kroon, Eugene D. M. B.] Armed Forces Res Inst Med Sci, Dept Retrovirol, US Component, Bangkok 10400, Thailand. [Jagodzinskr, Linda L.; Slike, Bonnie M.; Kim, Jerome H.; Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Allen, Isabel E.] Univ Calif San Francisco, Dept Biostat & Epidemiol, San Francisco, CA 94143 USA. [Slike, Bonnie M.; Ananworanich, Jintanat] Henry M Jackson Fdn Advancement Mil Med, Bethesda, MD USA. RP Valcour, VG (reprint author), Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA. EM vvalcour@memory.ucsf.edu FU National Institutes of Health [R21MH086341, R01MH095613]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DoD) from the National Institutes of Mental Health; Intramural research programs of the National Institute of Allergy and Infectious Diseases; Vaccine and Gene Therapy Institute FX This work is supported by R21MH086341 from the National Institutes of Health (VV), R01MH095613 from the National Institutes of Health (VV & SS), and a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DoD) which includes support from the National Institutes of Mental Health. The views expressed are those of the authors and should not be construed to represent the positions of the US Army or the Department of Defense or views of the National Institutes of Health. The authors received additional funding from the Intramural research programs of the National Institute of Allergy and Infectious Diseases and of the Vaccine and Gene Therapy Institute. The Thai Government Pharmaceutical Organization (tenofovir, lamivudine, efavirenz), Gilead (Truvada, Atripla), Merck ( Sustiva, Isentress), and ViiV Healthcare (Selzentry) provided antiretroviral therapy. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 26 TC 2 Z9 2 U1 1 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 10 PY 2015 VL 10 IS 11 AR e0142600 DI 10.1371/journal.pone.0142600 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CV7CT UT WOS:000364430700139 PM 26555069 ER PT J AU Gienger, EB Nguyen, PAT Chin, W Behler, KD Snyder, JF Wetzel, ED AF Gienger, Edwin B. Nguyen, Phuong-Anh T. Chin, Wai Behler, Kristopher D. Snyder, James F. Wetzel, Eric D. TI Microstructure and multifunctional properties of liquid plus polymer bicomponent structural electrolytes: Epoxy gels and porous monoliths SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article DE composites; gels; properties and characterization; structure-property relations ID ENERGY-STORAGE APPLICATIONS; LITHIUM-ION BATTERIES; COMPOSITE-MATERIALS; CARBON-FIBERS; PERFORMANCE; DESIGN; SUPERCAPACITORS; EMULSION AB Multifunctional structural batteries and supercapacitors have the potential to improve performance and efficiency in advanced lightweight systems. A critical requirement is a structural electrolyte with superior multifunctional performance. We present here structural electrolytes prepared by the integration of liquid electrolytes with structural epoxy networks. Two distinct approaches were investigated: direct blending of an epoxy resin with a poly(ethylene-glycol) (PEG)- or propylene carbonate (PC)-based liquid electrolyte followed by in-situ cure of the resin; and formation of a porous neat epoxy sample followed by backfill with a PC-based electrolyte. The results show that in situ cure of the electrolytes within the epoxy network does not lead to good multifunctional performance due to a combination of plasticization of the structural network and limited percolation of the liquid network. In contrast, addition of a liquid electrolyte to a porous monolith results in both good stiffness and high ionic conductivity that approach multifunctional goals. (C) 2015 Wiley Periodicals, Inc. C1 [Gienger, Edwin B.; Nguyen, Phuong-Anh T.; Chin, Wai; Behler, Kristopher D.; Snyder, James F.; Wetzel, Eric D.] US Army Res Lab, Mat & Mfg Sci Div, Aberdeen Proving Ground, MD 21005 USA. RP Wetzel, ED (reprint author), US Army Res Lab, Mat & Mfg Sci Div, Aberdeen Proving Ground, MD 21005 USA. EM eric.d.wetzel2.civ@mail.mil NR 32 TC 2 Z9 2 U1 6 U2 25 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0021-8995 EI 1097-4628 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD NOV 10 PY 2015 VL 132 IS 42 AR 42681 DI 10.1002/app.42681 PG 9 WC Polymer Science SC Polymer Science GA CT3LG UT WOS:000362707600006 ER PT J AU Matters, DA Fotiades, N Carroll, JJ Chiara, CJ McClory, JW Kawano, T Nelson, RO Devlin, M AF Matters, D. A. Fotiades, N. Carroll, J. J. Chiara, C. J. McClory, J. W. Kawano, T. Nelson, R. O. Devlin, M. TI New transitions and feeding of the J(pi) = (8(+)) isomer in Re-186 SO PHYSICAL REVIEW C LA English DT Article ID NUCLEAR-DATA SHEETS; NEUTRON; NUCLEOSYNTHESIS; TA-180(M) AB The spallation neutron source at the Los Alamos Neutron Science Center Weapons Neutron Research facility was used to populate excited states in Re-186 via (n, 2n gamma) reactions on an enriched Re-187 target. Gamma rays were detected with the GErmanium Array for Neutron Induced Excitations spectrometer, a Compton-suppressed array of 18 HPGe detectors. Incident neutron energies were determined by the time-of-flight technique and used to obtain gamma-ray excitation functions for the purpose of identifying. rays by reaction channel. Analysis of the singles gamma-ray spectrum gated on the neutron energy range 10 <= E-n <= 25 MeV resulted in five transitions and one level added to the 186Re level scheme. The additions include the placement of three. rays at 266.7, 381.2, and 647.7 keV which have been identified as feeding the 2.0x10(5) yr, J(pi) = (8(+)) isomer and yield an improved value of 148.2(5) keV for the isomer energy. These transitions may have astrophysical implications related to the use of the Re-Os cosmochronometer. C1 [Matters, D. A.; McClory, J. W.] Air Force Inst Technol, Wright Patterson AFB, OH 45433 USA. [Fotiades, N.; Kawano, T.; Nelson, R. O.; Devlin, M.] Los Alamos Natl Lab, Los Alamos, NM 87545 USA. [Carroll, J. J.] US Army Res Lab, Adelphi, MD 20783 USA. [Chiara, C. J.] US Army Res Lab, Oak Ridge Associated Univ Fellowship Program, Adelphi, MD 20783 USA. RP Matters, DA (reprint author), Air Force Inst Technol, Wright Patterson AFB, OH 45433 USA. EM david.matters@afit.edu RI Devlin, Matthew/B-5089-2013; OI Devlin, Matthew/0000-0002-6948-2154; Fotiadis, Nikolaos/0000-0003-1410-3871 FU U.S. Department of Energy [DE-AC52-06NA25396]; Army Research Laboratory [W911NF-12-2-0019]; Ecopulse, Inc. under ARL [W911QX09D0016-0004]; Defense Threat Reduction Agency; Domestic Nuclear Detection Office of the Department of Homeland Security FX This work was supported by the U.S. Department of Energy and has benefited from use of the LANSCE accelerator facility under Contract No. DE-AC52-06NA25396. This work was also supported by the Army Research Laboratory under Cooperative Agreement No. W911NF-12-2-0019. Target samples were provided by Ecopulse, Inc. under ARL Contract No. W911QX09D0016-0004. Additional funding was provided by the Defense Threat Reduction Agency and the Domestic Nuclear Detection Office of the Department of Homeland Security. NR 26 TC 2 Z9 2 U1 0 U2 1 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0556-2813 EI 1089-490X J9 PHYS REV C JI Phys. Rev. C PD NOV 9 PY 2015 VL 92 IS 5 AR 054304 DI 10.1103/PhysRevC.92.054304 PG 7 WC Physics, Nuclear SC Physics GA CV6VL UT WOS:000364409600006 ER PT J AU Hossain, F Arnold, J Beighley, E Brown, C Burian, S Chen, J Mitra, A Niyogi, D Pielke, R Tidwell, V Wegner, D AF Hossain, Faisal Arnold, Jeffrey Beighley, Ed Brown, Casey Burian, Steve Chen, Ji Mitra, Anindita Niyogi, Dev Pielke, Roger, Sr. Tidwell, Vincent Wegner, Dave TI What Do Experienced Water Managers Think of Water Resources of Our Nation and Its Management Infrastructure? SO PLoS One LA English DT Article AB This article represents the second report by an ASCE Task Committee "Infrastructure Impacts of Landscape-drivenWeather Change" under the ASCE Watershed Management Technical Committee and the ASCE Hydroclimate Technical Committee. Herein, the 'infrastructure impacts" are referred to as infrastructure-sensitive changes in weather and climate patterns (extremes and non-extremes) that are modulated, among other factors, by changes in landscape, land use and land cover change. In this first report, the article argued for explicitly considering the well-established feedbacks triggered by infrastructure systems to the land-atmosphere system via landscape change. In this report by the ASCE Task Committee (TC), we present the results of this ASCE TC's survey of a cross section of experienced water managers using a set of carefully crafted questions. These questions covered water resources management, infrastructure resiliency and recommendations for inclusion in education and curriculum. We describe here the specifics of the survey and the results obtained in the formof statistical averages on the 'perception' of thesemanagers. Finally, we discuss what these 'perception' averages may indicate to the ASCE TC and community as a whole for stewardship of the civil engineering profession. The survey and the responses gathered are not exhaustive nor do they represent the ASCE-endorsed viewpoint. However, the survey provides a critical first step to developing the framework of a research and education plan for ASCE. Given the Water Resources Reform and Development Act passed in 2014, we must now take into account the perceived concerns of the water management community. C1 [Hossain, Faisal] Univ Washington, Dept Civil & Environm Engn, Seattle, WA 98195 USA. [Arnold, Jeffrey] US Army Corps Engineers, Inst Water Resources, Seattle, WA USA. [Beighley, Ed] Northeastern Univ, Dept Civil & Environm Engn, Boston, MA 02115 USA. [Brown, Casey] Univ Massachusetts Amherst, Dept Civil & Environm Engn, Amherst, MA 01003 USA. [Burian, Steve] Univ Utah, Dept Civil & Environm Engn, Salt Lake City, UT 84112 USA. [Chen, Ji] Univ Hong Kong, Dept Civil Engn, Hong Kong, Hong Kong, Peoples R China. [Mitra, Anindita] CREA Affiliates, Seattle, WA 98103 USA. [Niyogi, Dev] Purdue Univ, Earth & Atmospher Sci, W Lafayette, IN 47907 USA. [Pielke, Roger, Sr.] Univ Colorado, CIRES, Boulder, CO 80309 USA. [Tidwell, Vincent] Sandia Natl Labs, Albuquerque, NM 87185 USA. [Wegner, Dave] US House Representatives, Washington, DC 20515 USA. RP Hossain, F (reprint author), Univ Washington, Dept Civil & Environm Engn, More Hall 201, Seattle, WA 98195 USA. EM fhossain@uw.edu RI Chen, Ji/C-1795-2009; OI Burian, Steven/0000-0003-0523-4968 FU ASCE Headquarters; ASCE Environment and Water Institute (EWRI) FX The authors acknowledge the support received from the ASCE Headquarters for conducting the survey using surveymonkey subscription. In particular, Gabrielle Dunkley at ASCE headquarters in Reston, Virginia is gratefully appreciated in setting up the survey. The Watershed Management Technical Council (WMTC) under the auspices of ASCE Environment and Water Institute (EWRI) is also acknowledged for approving the survey. NR 5 TC 0 Z9 0 U1 1 U2 10 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 6 PY 2015 VL 10 IS 11 AR e0142073 DI 10.1371/journal.pone.0142073 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CV6RT UT WOS:000364398700077 PM 26544045 ER PT J AU Blakely, JN Cooper, RM Corron, NJ AF Blakely, Jonathan N. Cooper, Roy M. Corron, Ned J. TI Regularly timed events amid chaos SO PHYSICAL REVIEW E LA English DT Article ID EQUATION AB We show rigorously that the solutions of a class of chaotic oscillators are characterized by regularly timed events in which the derivative of the solution is instantaneously zero. The perfect regularity of these events is in stark contrast with the well-known unpredictability of chaos. We explore some consequences of these regularly timed events through experiments using chaotic electronic circuits. First, we show that a feedback loop can be implemented to phase lock the regularly timed events to a periodic external signal. In this arrangement the external signal regulates the timing of the chaotic signal but does not strictly lock its phase. That is, phase slips of the chaotic oscillation persist without disturbing timing of the regular events. Second, we couple the regularly timed events of one chaotic oscillator to those of another. A state of synchronization is observed where the oscillators exhibit synchronized regular events while their chaotic amplitudes and phases evolve independently. Finally, we add additional coupling to synchronize the amplitudes, as well, however in the opposite direction illustrating the independence of the amplitudes from the regularly timed events. C1 [Blakely, Jonathan N.; Cooper, Roy M.; Corron, Ned J.] US Army Aviat & Missile Res, Charles M Bowden Lab, Ctr Dev & Engn, RDMR WDS WR, Redstone Arsenal, AL 35898 USA. RP Blakely, JN (reprint author), US Army Aviat & Missile Res, Charles M Bowden Lab, Ctr Dev & Engn, RDMR WDS WR, Redstone Arsenal, AL 35898 USA. OI Corron, Ned/0000-0002-3232-5024 NR 19 TC 3 Z9 3 U1 0 U2 5 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1539-3755 EI 1550-2376 J9 PHYS REV E JI Phys. Rev. E PD NOV 6 PY 2015 VL 92 IS 5 AR 052904 DI 10.1103/PhysRevE.92.052904 PG 6 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA CV4DO UT WOS:000364216400010 PM 26651759 ER PT J AU Chung, AW Kumar, MP Arnold, KB Yu, WH Schoen, MK Dunphy, LJ Suscovich, TJ Frahm, N Linde, C Mahan, AE Hoffner, M Streeck, H Ackerman, ME McElrath, MJ Schuitemaker, H Pau, MG Baden, LR Kim, JH Michael, NL Barouch, DH Lauffenburger, DA Alter, G AF Chung, Amy W. Kumar, Manu P. Arnold, Kelly B. Yu, Wen Han Schoen, Matthew K. Dunphy, Laura J. Suscovich, Todd J. Frahm, Nicole Linde, Caitlyn Mahan, Alison E. Hoffner, Michelle Streeck, Hendrik Ackerman, Margaret E. McElrath, M. Juliana Schuitemaker, Hanneke Pau, Maria G. Baden, Lindsey R. Kim, Jerome H. Michael, Nelson L. Barouch, Dan H. Lauffenburger, Douglas A. Alter, Galit TI Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology SO CELL LA English DT Article ID DEPENDENT CELLULAR CYTOTOXICITY; EBOLA-VIRUS INFECTION; IN-VIVO; PROTECTIVE EFFICACY; EFFECTOR FUNCTION; RHESUS-MONKEYS; NEONATAL MICE; ANTIBODY; IGA; CHALLENGES AB While antibody titers and neutralization are considered the gold standard for the selection of successful vaccines, these parameters are often inadequate predictors of protective immunity. As antibodies mediate an array of extra-neutralizing Fc functions, when neutralization fails to predict protection, investigating Fc-mediated activitymay help identify immunological correlates and mechanism(s) of humoral protection. Here, we used an integrative approach termed Systems Serology to analyze relationships among humoral responses elicited in four HIV vaccine trials. Each vaccine regimen induced a unique humoral "Fc fingerprint." Moreover, analysis of case: control data from the first moderately protective HIV vaccine trial, RV144, pointed to mechanistic insights into immune complex composition that may underlie protective immunity to HIV. Thus, multi-dimensional relational comparisons of vaccine humoral fingerprints offer a unique approach for the evaluation and design of novel vaccines against pathogens for which correlates of protection remain elusive. C1 [Chung, Amy W.; Yu, Wen Han; Schoen, Matthew K.; Suscovich, Todd J.; Linde, Caitlyn; Mahan, Alison E.; Hoffner, Michelle; Baden, Lindsey R.; Barouch, Dan H.; Alter, Galit] Ragon Inst MGH MIT & Harvard, Cambridge, MA 02139 USA. [Chung, Amy W.] Univ Melbourne, Peter Doherty Inst, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia. [Kumar, Manu P.; Arnold, Kelly B.; Yu, Wen Han; Dunphy, Laura J.; Lauffenburger, Douglas A.] MIT, Dept Biol Engn, Cambridge, MA 02139 USA. [Frahm, Nicole; McElrath, M. Juliana] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA. [Streeck, Hendrik; Kim, Jerome H.; Michael, Nelson L.] US Mil HIV Res Program, Dept Mol Virol & Pathogenesis, Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Streeck, Hendrik] Univ Duisburg Essen, Univ Hosp Essen, Inst Med Biol, D-45141 Essen, Germany. [Ackerman, Margaret E.] Thayer Sch Engn Dartmouth, Hanover, NH 03755 USA. [Schuitemaker, Hanneke; Pau, Maria G.] Crucell Holland BV, NL-2333 Leiden, Netherlands. [Baden, Lindsey R.] Brigham & Womens Hosp, Div Infect Dis, Boston, MA 02215 USA. [Kim, Jerome H.] Int Vaccine Inst, Seoul 151742, South Korea. [Barouch, Dan H.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Ctr Virol & Vaccine Res, Boston, MA 02215 USA. RP Lauffenburger, DA (reprint author), MIT, Dept Biol Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA. EM lauffen@mit.edu; galter@mgh.harvard.edu OI Chung, Amy/0000-0003-0020-9704 FU NIH [R01 AI080289]; Bill and Melinda Gates Foundation CAVD [OPP1032817]; Ragon Institute of MGH, MIT and Harvard; NIAID [HVTN204]; [DARPA-BAA-11-65] FX The following reagent was obtained through the AIDS Research and Reference Reagent Program, Division of AIDS, National Institute of Allergy and Infectious Diseases (NIAID), NIH: CEM. NKR-CCR5. We would like to thank (1) the NIAID and the NIAID-funded HVTN for providing specimens for the HVTN204 vaccine trial; (2) the MHRP for specimens from the RV144 vaccine trial; (3) the GSID for samples from the VAX003 vaccine trial; and (4) Dan Barouch for specimens from the experimental Ad26 vaccine trial. We would like to thank the RV144 study team for permission to include the case: control data in our manuscript and would like to specifically thank Drs. Peter Gilbert and Allan DeCamp and Ms. Elizabeth Heger for their assistance in RV144 case: control data collection. The opinions herein are those of the authors and should not be construed as official or representing the views of the U.S. Department of Defense or the Department of the Army. This work was supported by the NIH (grant R01 AI080289); the Bill and Melinda Gates Foundation CAVD (OPP1032817: Leveraging Antibody Effector Function); the Ragon Institute of MGH, MIT and Harvard; and DARPA-BAA-11-65. H. Schuitemaker and M.G.P. are employees of Crucell Holland B.V., a Janssen Pharmaceutical Company of Johnson & Johnson, and shareholders of Johnson & Johnson. H.S. and M.G.P. are employees of Crucell Holland B.V., The Janssen Pharmaceutical Companies of Johnson & Johnson, and shareholders of Johnson & Johnson. NR 43 TC 28 Z9 28 U1 6 U2 18 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 0092-8674 EI 1097-4172 J9 CELL JI Cell PD NOV 5 PY 2015 VL 163 IS 4 BP 988 EP 998 DI 10.1016/j.cell.2015.10.027 PG 11 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA CW2NS UT WOS:000364829700022 PM 26544943 ER PT J AU Rabago, CA Dingwell, JB Wilken, JM AF Rabago, Christopher A. Dingwell, Jonathan B. Wilken, Jason M. TI Reliability and Minimum Detectable Change of Temporal-Spatial, Kinematic, and Dynamic Stability Measures during Perturbed Gait SO PLOS ONE LA English DT Article ID TRANSTIBIAL AMPUTATION WALKING; TRAUMATIC BRAIN-INJURY; DUAL-TASK PERFORMANCE; DESTABILIZING ENVIRONMENTS; TREADMILL WALKING; YOUNG-ADULTS; RETEST RELIABILITY; DIVIDED ATTENTION; COGNITIVE TASK; HEALTHY-YOUNG AB Temporal-spatial, kinematic variability, and dynamic stability measures collected during perturbation-based assessment paradigms are often used to identify dysfunction associated with gait instability. However, it remains unclear which measures are most reliable for detecting and tracking responses to perturbations. This study systematically determined the between-session reliability and minimum detectable change values of temporal-spatial, kinematic variability, and dynamic stability measures during three types of perturbed gait. Twenty young healthy adults completed two identical testing sessions two weeks apart, comprised of an unperturbed and three perturbed (cognitive, physical, and visual) walking conditions in a virtual reality environment. Within each session, perturbation responses were compared to unperturbed walking using paired t-tests. Between-session reliability and minimum detectable change values were also calculated for each measure and condition. All temporal-spatial, kinematic variability and dynamic stability measures demonstrated fair to excellent between-session reliability. Minimal detectable change values, normalized to mean values ranged from 1-50%. Step width mean and variability measures demonstrated the greatest response to perturbations with excellent between-session reliability and low minimum detectable change values. Orbital stability measures demonstrated specificity to perturbation direction and sensitivity with excellent between-session reliability and low minimum detectable change values. We observed substantially greater between-session reliability and lower minimum detectable change values for local stability measures than previously described which may be the result of averaging across trials within a session and using velocity versus acceleration data for reconstruction of state spaces. Across all perturbation types, temporal-spatial, orbital and local measures were the most reliable measures with the lowest minimum detectable change values, supporting their use for tracking changes over multiple testing sessions. The between-session reliability and minimum detectable change values reported here provide an objective means for interpreting changes in temporal-spatial, kinematic variability, and dynamic stability measures during perturbed walking which may assist in identifying instability. C1 [Rabago, Christopher A.; Wilken, Jason M.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ctr Intrepid, Jbsa Ft Sam Houston, TX 78234 USA. [Rabago, Christopher A.; Wilken, Jason M.] Dept Def & Vet Affairs Extrem Trauma, Jbsa Ft Sam Houston, TX USA. [Rabago, Christopher A.; Wilken, Jason M.] Amputat Ctr Excellence, Jbsa Ft Sam Houston, TX USA. [Dingwell, Jonathan B.] Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA. RP Rabago, CA (reprint author), Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ctr Intrepid, Jbsa Ft Sam Houston, TX 78234 USA. EM Christopher.A.Rabago.civ@mail.mil OI Rabago, Christopher/0000-0002-4484-0613 FU Medical Research and Materiel Command's Military Operational Medicine Research Program [W81XWH-09-P-0874] FX Support provided by Medical Research and Materiel Command's Military Operational Medicine Research Program, http://mrmc.amedd.army.mil, Grant W81XWH-09-P-0874 (to JMW). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 71 TC 2 Z9 2 U1 2 U2 8 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 4 PY 2015 VL 10 IS 11 AR e0142083 DI 10.1371/journal.pone.0142083 PG 22 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CV5GZ UT WOS:000364298400130 PM 26535580 ER PT J AU Rogier, E Wiegand, R Moss, D Priest, J Angov, E Dutta, S Journel, I Jean, SE Mace, K Chang, M Lemoine, JF Udhayakumar, V Barnwell, JW AF Rogier, Eric Wiegand, Ryan Moss, Delynn Priest, Jeff Angov, Evelina Dutta, Sheetij Journel, Ito Jean, Samuel E. Mace, Kimberly Chang, Michelle Lemoine, Jean Frantz Udhayakumar, Venkatachalam Barnwell, John W. TI Multiple comparisons analysis of serological data from an area of low Plasmodium falciparum transmission SO MALARIA JOURNAL LA English DT Article DE Serology; Plasmodium falciparum; Multiplex; ELISA; Distribution ID IMMUNOGLOBULIN-G ANTIBODIES; CRYPTOSPORIDIUM-PARVUM ANTIGENS; MALARIA TRANSMISSION; ASSAY DETECTION; BEAD ASSAY; INTENSITY; INFECTION; RECOGNIZE; REGION; HAITI AB Background: As a nation reduces the burden of falciparum malaria, identifying areas of transmission becomes increasingly difficult. Over the past decade, the field of utilizing malaria serological assays to measure exposure has grown rapidly, and a variety of serological methods for data acquisition and analysis of human IgG against falciparum antigens are available. Here, different immunoassays and statistical methods are utilized to analyse samples from a low transmission setting and directly compare the estimates generated. Methods: A subset of samples (n = 580) from a 2012 Haitian nationwide malaria survey was employed as sample population of low falciparum endemicity. In addition to the Haitian samples, samples from 247 US residents were used as a reference population of ` true seronegatives'. Data acquisition was performed through standard ELISA and bead-based multiplex assays assaying for IgG antibodies to the Plasmodium falciparum antigens MSP-1p19, MSP1p42( D), MSP-1p42(F), and AMA-1. Appropriate parametric distributions and seropositivity cutoff values were determined by statistical measures. Results: Data from both assays showed a strong positive skew, and the lognormal distribution was found to be an appropriate statistical fit to the Haitian and American populations. The American samples served as a good serological true negative population for the multiplex assay, but not for ELISA-based data. Mixture model approaches to determine seronegative and seropositive populations from the Haitian data showed a high degree of distribution overlap- likely due to the historical low falciparum transmission in this nation. Different fittings to the reversible catalytic model resulted depending upon the immunoassay utilized and seropositivity cutoff method employed. Data were also analysed through fitting to penalized B-splines, presenting another possible analytical tool for the analysis of malaria serological data. Conclusions: Standardization of serological techniques and analyses may prove difficult as some tools can prove to be more useful depending on the area and parasite in question, making clear interpretation a vital pursuit. The presented analysis in the low-endemic nation of Haiti found malaria-naive US residents to be an appropriate seronegative reference population for the multiplex assay, and this assay providing consistent estimates between MSP-1 and AMA-1 antigens of percent seropositives for this low-endemic population. C1 [Rogier, Eric; Wiegand, Ryan; Moss, Delynn; Priest, Jeff; Mace, Kimberly; Chang, Michelle; Udhayakumar, Venkatachalam; Barnwell, John W.] Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA 30333 USA. [Angov, Evelina; Dutta, Sheetij] Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD USA. [Journel, Ito] Minist Sante Publ & Populat, Lab Natl Sante Publ, Port Au Prince, Haiti. [Jean, Samuel E.] Populat Serv Int, Org Haitienne Mkt Social Sante, Port Au Prince, Haiti. [Lemoine, Jean Frantz] MSPP, Programme Natl Controle Malaria, Port Au Prince, Haiti. RP Rogier, E (reprint author), Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA 30333 USA. EM erogier@cdc.gov FU Global Fund for HIV, Malaria, and Tuberculosis; Population Services International; CDC FX This study was funded by The Global Fund for HIV, Malaria, and Tuberculosis in collaboration with Population Services International and CDC. The authors would like to thank Chris Drakeley for reviewing the manuscript and Jamie Griffin for STATA statistical code. NR 39 TC 1 Z9 1 U1 0 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD NOV 4 PY 2015 VL 14 AR 436 DI 10.1186/s12936-015-0955-1 PG 12 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA CV1HF UT WOS:000364003600007 PM 26537125 ER PT J AU Buller, MJ Tharion, WJ Duhamel, CM Yokota, M AF Buller, Mark J. Tharion, William J. Duhamel, Cynthia M. Yokota, Miyo TI Real-time core body temperature estimation from heart rate for first responders wearing different levels of personal protective equipment SO ERGONOMICS LA English DT Article DE non-invasive; thermal-work strain; heat strain; fire-fighter monitoring; core temperature prediction ID THERMOREGULATORY RESPONSES; RECTAL TEMPERATURES; SKIN TEMPERATURE; SURFACE-AREA; EXERCISE; STRAIN; HUMANS; SYSTEM; FLUX; MASS AB First responders often wear personal protective equipment (PPE) for protection from on-the-job hazards. While PPE ensembles offer individuals protection, they limit one's ability to thermoregulate, and can place the wearer in danger of heat exhaustion and higher cardiac stress. Automatically monitoring thermal-work strain is one means to manage these risks, but measuring core body temperature (T-c) has proved problematic. An algorithm that estimates T-c from sequential measures of heart rate (HR) was compared to the observed T-c from 27 US soldiers participating in three different chemical/biological training events (45-90min duration) while wearing PPE. Hotter participants (higher T-c) averaged (HRs) of 140bpm and reached T-c around 39 degrees C. Overall the algorithm had a small bias (0.02 degrees C) and root mean square error (0.21 degrees C). Limits of agreement (LoA0.48 degrees C) were similar to comparisons of T-c measured by oesophageal and rectal probes. The algorithm shows promise for use in real-time monitoring of encapsulated first responders. Practitioner Summary: An algorithm to estimate core temperature (T-c) from non-invasive measures of HR was validated. Three independent studies (n=27) compared the estimated T-c to the observed T-c in humans participating in chemical/biological hazard training. The algorithm's bias and variance to observed data were similar to that found from comparisons of oesophageal and rectal measurements. C1 [Buller, Mark J.; Tharion, William J.; Duhamel, Cynthia M.; Yokota, Miyo] US Army Res Inst Environm Med, Natick, MA 01760 USA. RP Buller, MJ (reprint author), US Army Res Inst Environm Med, Kansas St, Natick, MA 01760 USA. EM mark.j.buller.civ@mail.mil NR 38 TC 3 Z9 3 U1 2 U2 9 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0014-0139 EI 1366-5847 J9 ERGONOMICS JI Ergonomics PD NOV 2 PY 2015 VL 58 IS 11 BP 1830 EP 1841 DI 10.1080/00140139.2015.1036792 PG 12 WC Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Engineering; Psychology GA CZ0ZQ UT WOS:000366835800005 PM 25967760 ER PT J AU Das, S Nag, A Liang, JX Bunck, DN Umeda, A Farrow, B Coppock, MB Sarkes, DA Finch, AS Agnew, HD Pitram, S Lai, B Yu, MB Museth, AK Deyle, KM Lepe, B Rodriguez-Rivera, FP McCarthy, A Alvarez-Villalonga, B Chen, A Heath, J Stratis-Cullum, DN Heath, JR AF Das, Samir Nag, Arundhati Liang, JingXin Bunck, David N. Umeda, Aiko Farrow, Blake Coppock, Matthew B. Sarkes, Deborah A. Finch, Amethist S. Agnew, Heather D. Pitram, Suresh Lai, Bert Yu, Mary Beth Museth, A. Katrine Deyle, Kaycie M. Lepe, Bianca Rodriguez-Rivera, Frances P. McCarthy, Amy Alvarez-Villalonga, Belen Chen, Ann Heath, John Stratis-Cullum, Dimitra N. Heath, James R. TI A General Synthetic Approach for Designing Epitope Targeted Macrocyclic Peptide Ligands SO ANGEWANDTE CHEMIE-INTERNATIONAL EDITION LA English DT Article DE click chemistry; combinatorial chemistry; macrocyclic ligands; metathesis; peptides ID SITU CLICK CHEMISTRY; PROTEIN-CAPTURE AGENTS; ANTIBODY; BINDING; CYCLOADDITION; INHIBITORS; INTERFACE; DIVERSITY; DISCOVERY; LIBRARIES AB We describe a general synthetic strategy for developing high-affinity peptide binders against specific epitopes of challenging protein biomarkers. The epitope of interest is synthesized as a polypeptide, with a detection biotin tag and a strategically placed azide (or alkyne) presenting amino acid. This synthetic epitope (SynEp) is incubated with a library of complementary alkyne or azide presenting peptides. Library elements that bind the SynEp in the correct orientation undergo the Huisgen cycloaddition, and are covalently linked to the SynEp. Hit peptides are tested against the full-length protein to identify the best binder. We describe development of epitope-targeted linear or macrocycle peptide ligands against 12 different diagnostic or therapeutic analytes. The general epitope targeting capability for these low molecular weight synthetic ligands enables a range of therapeutic and diagnostic applications, similar to those of monoclonal antibodies. C1 [Das, Samir; Nag, Arundhati; Liang, JingXin; Bunck, David N.; Umeda, Aiko; Farrow, Blake; Yu, Mary Beth; Museth, A. Katrine; Deyle, Kaycie M.; Lepe, Bianca; Rodriguez-Rivera, Frances P.; McCarthy, Amy; Alvarez-Villalonga, Belen; Chen, Ann; Heath, John; Heath, James R.] CALTECH, Dept Chem & Chem Engn, Pasadena, CA 91125 USA. [Coppock, Matthew B.; Sarkes, Deborah A.; Finch, Amethist S.; Stratis-Cullum, Dimitra N.] US Army Res Lab, Biotechnol Branch, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. [Agnew, Heather D.; Pitram, Suresh; Lai, Bert] Indi Mol, Culver City, CA 90230 USA. RP Heath, JR (reprint author), CALTECH, Dept Chem & Chem Engn, 1200 E Calif Blvd, Pasadena, CA 91125 USA. EM heath@caltech.edu OI McCarthy, Amy/0000-0003-3456-0383 FU Bill and Melinda Gates Foundation; Institute for Collaborative Biotechnologies from the U.S. Army Research Office [W911NF-09-0001]; Defense Advanced Research Projects Agency (DARPA) [HR0011-11-2-0006]; Jean Perkins Foundation; National Cancer Institute [1U54 CA199090-01] FX The various PCCs and methods reported here were developed under funding from the Bill and Melinda Gates Foundation, the Institute for Collaborative Biotechnologies (W911NF-09-0001) from the U.S. Army Research Office, the Defense Advanced Research Projects Agency (DARPA) through the Cooperative Agreement HR0011-11-2-0006, the Jean Perkins Foundation, and the National Cancer Institute through grant #1U54 CA199090-01 (JRH PI). NR 38 TC 5 Z9 5 U1 3 U2 43 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 1433-7851 EI 1521-3773 J9 ANGEW CHEM INT EDIT JI Angew. Chem.-Int. Edit. PD NOV 2 PY 2015 VL 54 IS 45 BP 13219 EP 13224 DI 10.1002/anie.201505243 PG 6 WC Chemistry, Multidisciplinary SC Chemistry GA CU7BY UT WOS:000363691500008 PM 26377818 ER PT J AU Handler, FA Edmonds, JM AF Handler, F. A. Edmonds, Jason M. TI Quantitative Analysis of Effects of UV Exposure and Spore Cluster Size on Deposition and Inhalation Hazards of Bacillus Spores SO AEROSOL SCIENCE AND TECHNOLOGY LA English DT Article ID ANTHRACIS SPORES; INACTIVATION; RESISTANCE; BACTERIA; MODEL; SENSITIVITY; PERSISTENCE; ENVIRONMENT; ATMOSPHERE; RADIATION AB Reviews of the effects of solar UV radiation on the survival rate of aerosolized biological material found that the current understanding of environmental viability degradation in response scenarios is insufficient to inform appropriate emergency response measures. We evaluated the effects of UV degradation, in terms of the number of viable, culture forming units as a function of spore cluster size on the downwind hazard presented by a release of a biological organism such as Bacillus anthracis into the environment. We used experimentally derived survival rates for B. atrophaeus var. globigii (BG) spores and BG spore clusters (as a surrogate for Bacillus anthracis) of various sizes exposed to UVC fluences to derive predicted survival rates for single spores and spore clusters of up to 10 mu m. For the range of weather conditions encountered in hazard estimates, as characterized by Pasquill-Gifford-Turner classes, we calculated and compared the downwind inhalation and deposition hazards for single spores versus spore clusters up to 10m diameter based on standard plume dispersion and particle deposition models. These models can be used to predict survival rates for solar exposure taking into account differences in plume depletion due to deposition, and differences in dose-response due to particle size. The combined effects of solar degradation and size-dependent deposition resulted in clusters presenting from a few to up to 10 orders of magnitude greater hazards than single spores depending on meteorological conditions and downwind distance.Copyright 2015 American Association for Aerosol Research C1 [Handler, F. A.] Panasynoptics Corp, Mclean, VA USA. [Edmonds, Jason M.] US Army, Dept Def, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Edmonds, JM (reprint author), US Army, Dept Def, Edgewood Chem Biol Ctr, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM jason.m.edmonds2.civ@mail.mil NR 34 TC 2 Z9 2 U1 1 U2 13 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0278-6826 EI 1521-7388 J9 AEROSOL SCI TECH JI Aerosol Sci. Technol. PD NOV 2 PY 2015 VL 49 IS 11 BP 1121 EP 1130 DI 10.1080/02786826.2015.1102857 PG 10 WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA CU4BW UT WOS:000363472100001 ER PT J AU Friedl, KE Knapik, JJ Hakkinen, K Baumgartner, N Groeller, H Taylor, NAS Duarte, AFA Kyrolainen, H Jones, BH Kraemer, WJ Nindl, BC AF Friedl, Karl E. Knapik, Joseph J. Hakkinen, Keijo Baumgartner, Neal Groeller, Herbert Taylor, Nigel A. S. Duarte, Antonio F. A. Kyrolainen, Heikki Jones, Bruce H. Kraemer, William J. Nindl, Bradley C. TI PERSPECTIVES ON AEROBIC AND STRENGTH INFLUENCES ON MILITARY PHYSICAL READINESS: REPORT OF AN INTERNATIONAL MILITARY PHYSIOLOGY ROUNDTABLE SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Article DE physical endurance/physiology; muscle strength/physiology; physical fitness/physiology; employment/standards; military personnel; sex factors ID TRAINING-RELATED INJURIES; RISK-FACTORS; LOAD CARRIAGE; RESISTANCE EXERCISE; RUNNING PERFORMANCE; MUSCLE HYPERTROPHY; EXPLOSIVE-STRENGTH; GENDER-DIFFERENCES; MIDDLE-DISTANCE; HEALTHY-ADULTS AB Physical fitness training of military recruits is an enduring focus of armies. This is important for safe and effective performance of general tasks that anyone may have to perform in a military setting as well as preparation for more specialized training in specific job specialties. Decades of studies on occupationally specific physical requirements have characterized the dual aerobic and strength demands of typical military tasks; however, scientifically founded strategies to prepare recruits with a good mix of these 2 physiologically opposing capabilities have not been well established. High levels of aerobic training can compromise resistance training gains and increase injury rates. Resistance training requires a greater commitment of time and resources as well as a greater understanding of the science to produce true strength gains that may be beneficial to military performance. These are critical issues for modern armies with increased demands for well-prepared soldiers and fewer injury losses. The actual physical requirements tied to metrics of success in military jobs are also under renewed examination as women are increasingly integrated into military jobs previously performed only by men. At the third International Congress on Soldiers' Physical Performance, a roundtable of 10 physiologists with military expertise presented comparative perspectives on aerobic and strength training. These topics included the physiological basis of training benefits, how to train effectively, how to measure training effectiveness, considerations for the integration of women, and the big perspective. Key discussion points centered on (a) the significance of findings from research on integrated training, (b) strategies for effective strength development, and (c) injury reduction in training as well as the benefits of improved fitness to injury reduction across the force. C1 [Friedl, Karl E.; Knapik, Joseph J.] US Army, Environm Med Res Inst, ORISE Knowledge Preservat Program, Natick, MA 01760 USA. [Knapik, Joseph J.; Nindl, Bradley C.] US Army, Publ Hlth Ctr Provis, Aberdeen Proving Ground, MD USA. [Hakkinen, Keijo; Kyrolainen, Heikki] Univ Jyvaskyla, Dept Biol Phys Act, Jyvaskyla, Finland. [Baumgartner, Neal] USAF Fitness Testing & Stand Unit, Joint Base San Antonio Randolph, San Antonio, TX USA. [Groeller, Herbert; Taylor, Nigel A. S.] Univ Wollongong, Sch Med, Ctr Human & Appl Physiol, Wollongong, NSW, Australia. [Duarte, Antonio F. A.] Brazilian Army Res Inst Phys Fitness, IPCFEx, Rio De Janeiro, Brazil. [Duarte, Antonio F. A.] Univ Florida, Dept Appl Physiol & Kinesiol, Gainesville, FL USA. [Jones, Bruce H.] US Army, Directorate Epidemiol & Dis Surveillance, Publ Hlth Command, Aberdeen Proving Ground, MD USA. [Kraemer, William J.] Ohio State Univ, Dept Human Sci, Columbus, OH 43210 USA. [Nindl, Bradley C.] Univ Pittsburgh, Sch Hlth & Rehabil Sci, Dept Sports Med & Nutr, Neuromuscular Res Lab,Warrior Human Performance R, Pittsburgh, PA USA. RP Friedl, KE (reprint author), US Army, Environm Med Res Inst, ORISE Knowledge Preservat Program, Natick, MA 01760 USA. EM friedlke@gmail.com NR 103 TC 2 Z9 2 U1 3 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1064-8011 EI 1533-4287 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD NOV PY 2015 VL 29 SU 11 BP S10 EP S23 PG 14 WC Sport Sciences SC Sport Sciences GA DN5KB UT WOS:000377104500003 PM 26506170 ER PT J AU Gibala, MJ Gagnon, PJ Nindl, BC AF Gibala, Martin J. Gagnon, Patrick J. Nindl, Bradley C. TI MILITARY APPLICABILITY OF INTERVAL TRAINING FOR HEALTH AND PERFORMANCE SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Review DE high-intensity exercise; cardiorespiratory fitness; aerobic energy metabolism ID HIGH-INTENSITY; LOW-VOLUME; SPRINT INTERVAL; EXERCISE PERFORMANCE; SKELETAL-MUSCLE; AEROBIC POWER; ENDURANCE; ADAPTATIONS; FITNESS; ADULTS AB Militaries from around the globe have predominantly used endurance training as their primary mode of aerobic physical conditioning, with historical emphasis placed on the long distance run. In contrast to this traditional exercise approach to training, interval training is characterized by brief, intermittent bouts of intense exercise, separated by periods of lower intensity exercise or rest for recovery. Although hardly a novel concept, research over the past decade has shed new light on the potency of interval training to elicit physiological adaptations in a time-efficient manner. This work has largely focused on the benefits of low-volume interval training, which involves a relatively small total amount of exercise, as compared with the traditional high-volume approach to training historically favored by militaries. Studies that have directly compared interval and moderate-intensity continuous training have shown similar improvements in cardiorespiratory fitness and the capacity for aerobic energy metabolism, despite large differences in total exercise and training time commitment. Interval training can also be applied in a calisthenics manner to improve cardiorespiratory fitness and strength, and this approach could easily be incorporated into a military conditioning environment. Although interval training can elicit physiological changes in men and women, the potential for sex-specific adaptations in the adaptive response to interval training warrants further investigation. Additional work is needed to clarify adaptations occurring over the longer term; however, interval training deserves consideration from a military applicability standpoint as a time-efficient training strategy to enhance soldier health and performance. There is value for military leaders in identifying strategies that reduce the time required for exercise, but nonetheless provide an effective training stimulus. C1 [Gibala, Martin J.] McMaster Univ, Dept Kinesiol, Hamilton, ON, Canada. [Gagnon, Patrick J.] Natl Def, Canadian Forces Morale & Welf Serv, Human Performance Res & Dev, Ottawa, ON, Canada. [Nindl, Bradley C.] Univ Pittsburgh, Sch Hlth & Rehabil Sci, Dept Sports Med & Nutr, Warrior Human Performance Res Ctr,Neuromuscular R, Pittsburgh, PA USA. [Nindl, Bradley C.] US Army, Publ Hlth Ctr Provis, Aberdeen Proving Ground, MD USA. RP Gibala, MJ (reprint author), McMaster Univ, Dept Kinesiol, Hamilton, ON, Canada. EM gibalam@mcmaster.ca FU Natural Sciences and Engineering Research Council of Canada FX The Natural Sciences and Engineering Research Council of Canada supported work cited from the laboratory of MJG. NR 31 TC 0 Z9 0 U1 11 U2 17 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1064-8011 EI 1533-4287 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD NOV PY 2015 VL 29 SU 11 BP S40 EP S45 PG 6 WC Sport Sciences SC Sport Sciences GA DN5KB UT WOS:000377104500007 PM 26506197 ER PT J AU Hydren, JR Zambraski, EJ AF Hydren, Jay R. Zambraski, Edward J. TI INTERNATIONAL RESEARCH CONSENSUS: IDENTIFYING MILITARY RESEARCH PRIORITIES AND GAPS SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Article DE topics; injury; training; performance; prevention; fitness; operational environments AB A multidisciplinary survey was administered to military performance researchers attending the Third International Conference on Soldier Physical Performance to obtain their opinions of the priority levels and importance of research topics related to soldier health and determinants of soldier physical performance. Respondents included 140 individuals from 22 different countries, of which 96% had at least a graduate degree and 79% were associated with a military organization. The top 5 highest importance/priority research topics were (a) physical demands in operational environments, (b) measuring physical performance/fitness, (c) musculoskeletal injury mitigation programs, (d) physical employment standards, and (e) physical strength-training programs. Of what individuals thought were their most important topics, 50% reported these were not currently being researched because of higher priorities, insufficient funding, or the lack of scientific expertise. A theme analysis of researchtopic areas that were important and not being researched indicated that physical employment standards and physical training studies related to soldiers' health and performance are knowledge gaps. Although these experienced researchers had diverse backgrounds and were working on a wide array of research topics, there was a surprisingly clear consensus on what they thought were important topics that needed to be addressed in common between countries or militaries. C1 [Hydren, Jay R.; Zambraski, Edward J.] US Army, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. RP Hydren, JR (reprint author), US Army, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. EM jayhydren@gmail.com RI Hydren, Jay/H-3654-2016 OI Hydren, Jay/0000-0001-9385-8898 NR 0 TC 0 Z9 0 U1 3 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1064-8011 EI 1533-4287 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD NOV PY 2015 VL 29 SU 11 BP S24 EP S27 PG 4 WC Sport Sciences SC Sport Sciences GA DN5KB UT WOS:000377104500004 PM 26506193 ER PT J AU Lee, JKW Kenefick, RW Cheuvront, SN AF Lee, Jason K. W. Kenefick, Robert W. Cheuvront, Samuel N. TI NOVEL COOLING STRATEGIES FOR MILITARY TRAINING AND OPERATIONS SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Review DE ice slurry; arm immersion; microclimate cooling; performance ID SKIN TEMPERATURE; ENDURANCE CAPACITY; CORE TEMPERATURE; HEAT ILLNESS; HOT WEATHER; ICE SLURRY; EXERCISE; PERFORMANCE; INTERMITTENT; HANDS AB The deleterious effects of environmental heat stress, combined with high metabolic loads and protective clothing and equipment of the modern Warfighter, impose severe heat strain, impair task performance, and increase risk of heat illness, thereby reducing the chance for mission success. Despite the implementation of heat-risk mitigation procedures over the past decades, task performance still suffers and exertional heat illness remains a major military problem. We review 3 novel heat mitigation strategies that may be implemented in the training or operational environment to reduce heat strain and the risk of exertional heat illness. These strategies include ingestion of ice slurry, arm immersion cooling, and microclimate cooling. Each of these strategies is suitable for use in different scenarios and the choice of cooling strategy is contingent on the requirements, circumstances, and constraints of the training and operational scenario. Ingestion of ice slurry and arm immersion cooling are practical strategies that may be implemented during training scenarios; ice slurry can be ingested before and during exercise, whereas arm immersion cooling can be administered after exercise-heat exposure. In the operational environment, existing microclimate cooling can be implemented with retrofitted vehicles and as an unmounted system, and it has the potential for use in many military occupational scenarios. This review will discuss the efficacy, limitations, and practical considerations for field implementation of each strategy. C1 [Lee, Jason K. W.] DSO Natl Labs, Def Med & Environm Res Inst, Combat Protect & Performance, Singapore, Singapore. [Lee, Jason K. W.] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore 117595, Singapore. [Lee, Jason K. W.] Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore 639798, Singapore. [Kenefick, Robert W.; Cheuvront, Samuel N.] US Army, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Lee, JKW (reprint author), DSO Natl Labs, Def Med & Environm Res Inst, Combat Protect & Performance, Singapore, Singapore. EM lkaiwei@dso.org.sg NR 33 TC 2 Z9 2 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1064-8011 EI 1533-4287 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD NOV PY 2015 VL 29 SU 11 BP S77 EP S81 PG 5 WC Sport Sciences SC Sport Sciences GA DN5KB UT WOS:000377104500013 PM 26506203 ER PT J AU Nindl, BC Jaffin, DP Dretsch, MN Cheuvront, SN Wesensten, NJ Kent, ML Grunberg, NE Pierce, JR Barry, ES Scott, JM Young, AJ O'Connor, FG Deuster, PA AF Nindl, Bradley C. Jaffin, Dianna P. Dretsch, Michael N. Cheuvront, Samuel N. Wesensten, Nancy J. Kent, Michael L. Grunberg, Neil E. Pierce, Joseph R. Barry, Erin S. Scott, Jonathan M. Young, Andrew J. O'Connor, Francis G. Deuster, Patricia A. TI HUMAN PERFORMANCE OPTIMIZATION METRICS: CONSENSUS FINDINGS, GAPS, AND RECOMMENDATIONS FOR FUTURE RESEARCH SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Article DE human dimension strategy; human potential; performance enhancement; program evaluation; tactical athlete; total force fitness; holistic health ID TEST-RETEST RELIABILITY; SITUATIONAL JUDGMENT TESTS; IMPLICIT ASSOCIATION TEST; SOFT-TISSUE COMPOSITION; TRAUMATIC BRAIN-INJURY; X-RAY ABSORPTIOMETRY; VERBAL-LEARNING TEST; SLEEP LATENCY TEST; RISK-TASK BART; WORKING-MEMORY AB Human performance optimization (HPO) is defined as "the process of applying knowledge, skills and emerging technologies to improve and preserve the capabilities of military members, and organizations to execute essential tasks." The lack of consensus for operationally relevant and standardized metrics that meet joint military requirements has been identified as the single most important gap for research and application of HPO. In 2013, the Consortium for Health and Military Performance hosted a meeting to develop a toolkit of standardized HPO metrics for use in military and civilian research, and potentially for field applications by commanders, units, and organizations. Performance was considered from a holistic perspective as being influenced by various behaviors and barriers. To accomplish the goal of developing a standardized toolkit, key metrics were identified and evaluated across a spectrum of domains that contribute to HPO: physical performance, nutritional status, psychological status, cognitive performance, environmental challenges, sleep, and pain. These domains were chosen based on relevant data with regard to performance enhancers and degraders. The specific objectives at this meeting were to (a) identify and evaluate current metrics for assessing human performance within selected domains; (b) prioritize metrics within each domain to establish a human performance assessment toolkit; and (c) identify scientific gaps and the needed research to more effectively assess human performance across domains. This article provides of a summary of 150 total HPO metrics across multiple domains that can be used as a starting point-the beginning of an HPO toolkit: physical fitness (29 metrics), nutrition (24 metrics), psychological status (36 metrics), cognitive performance (35 metrics), environment (12 metrics), sleep (9 metrics), and pain (5 metrics). These metrics can be particularly valuable as the military emphasizes a renewed interest in Human Dimension efforts, and leverages science, resources, programs, and policies to optimize the performance capacities of all Service members. C1 [Nindl, Bradley C.; Pierce, Joseph R.] Univ Pittsburgh, Sch Hlth & Rehabil Sci, Dept Sports Med & Nutr, Neuromuscular Res Lab,Warrior Human Performance R, Pittsburgh, PA USA. [Nindl, Bradley C.] US Army Publ Hlth Ctr Provis, Aberdeen Proving Ground, MD USA. [Jaffin, Dianna P.; Grunberg, Neil E.; Barry, Erin S.; Scott, Jonathan M.; O'Connor, Francis G.; Deuster, Patricia A.] Uniformed Serv Univ Hlth Sci, Consortium Hlth & Mil Performance, Dept Mil & Emergency Med, Bethesda, MD 20814 USA. [Dretsch, Michael N.] HQ Army Training & Doctrine Command, Human Dimens Div, Ft Eustis, VA USA. [Cheuvront, Samuel N.; Young, Andrew J.] US Army Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA USA. [Cheuvront, Samuel N.; Young, Andrew J.] US Army Res Inst Environm Med, Div Nutr, Natick, MA USA. [Wesensten, Nancy J.] Walter Reed Army Inst Res, Behav Biol Branch, Silver Spring, MD USA. [Kent, Michael L.] Walter Reed Natl Mil Med Ctr, Div Anesthesiol, Bethesda, MD USA. RP Nindl, BC (reprint author), Univ Pittsburgh, Sch Hlth & Rehabil Sci, Dept Sports Med & Nutr, Neuromuscular Res Lab,Warrior Human Performance R, Pittsburgh, PA USA. EM Bnindl@pitt.edu NR 175 TC 1 Z9 1 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1064-8011 EI 1533-4287 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD NOV PY 2015 VL 29 SU 11 BP S221 EP S245 PG 25 WC Sport Sciences SC Sport Sciences GA DN5KB UT WOS:000377104500038 PM 26506192 ER PT J AU Nindl, BC Alvar, BA Dudley, JR Favre, MW Martin, GJ Sharp, MA Warr, BJ Stephenson, MD Kraemer, WJ AF Nindl, Bradley C. Alvar, Brent A. Dudley, Jason R. Favre, Mike W. Martin, Gerard J. Sharp, Marilyn A. Warr, Brad J. Stephenson, Mark D. Kraemer, William J. TI EXECUTIVE SUMMARY FROM THE NATIONAL STRENGTH AND CONDITIONING ASSOCIATION'S SECOND BLUE RIBBON PANEL ON MILITARY PHYSICAL READINESS: MILITARY PHYSICAL PERFORMANCE TESTING SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Article DE tactical training; military fitness; field-expedient testing ID FITNESS; GUARD AB The National Strength and Conditioning Association's tactical strength and conditioning program sponsored the second Blue Ribbon Panel on military physical readiness: military physical performance testing, April 18-19, 2013, Norfolk, VA. This meeting brought together a total of 20 subject matter experts (SMEs) from the U.S. Air Force, Army, Marine Corps, Navy, and academia representing practitioners, operators, researchers, and policy advisors to discuss the current state of physical performance testing across the Armed Services. The SME panel initially rated 9 common military tasks (jumping over obstacles, moving with agility, carrying heavy loads, dragging heavy loads, running long distances, moving quickly over short distances, climbing over obstacles, lifting heavy objects, loading equipment) by the degree to which health-related fitness components (e.g., aerobic fitness, muscular strength, muscular endurance, flexibility, and body composition) and skill-related fitness components (e.g., muscular power, agility, balance, coordination, speed, and reaction time) were required to accomplish these tasks. A scale from 1 to 10 (10 being highest) was used. Muscular strength, power, and endurance received the highest rating scores. Panel consensus concluded that (a) selected fitness components (particularly for skill-related fitness components) are currently not being assessed by the military; (b) field-expedient options to measure both health-based and skill-based fitness components are currently available; and (c) 95% of the panel concurred that all services should consider a tier II test focused on both health-related and skill-related fitness components based on occupational, functional, and tactical military performance requirements. C1 [Nindl, Bradley C.] Univ Pittsburgh, Sch Hlth & Rehabil Sci, Dept Sports Med & Nutr, Neuromuscular Res Lab,Warrior Human Performance R, Pittsburgh, PA USA. [Nindl, Bradley C.] US Army Publ Hlth Ctr Provis, Aberdeen Proving Ground, MD USA. [Alvar, Brent A.] Rocky Mt Univ Hlth Profess, Provo, UT USA. [Dudley, Jason R.] Cent Washington Univ, Dept Athlet, Ellensburg, WA USA. [Favre, Mike W.] Univ Michigan, Dept Athlet, Ann Arbor, MI 48109 USA. [Martin, Gerard J.] Univ Connecticut, Dept Athlet, Storrs, CT USA. [Sharp, Marilyn A.; Warr, Brad J.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA USA. [Stephenson, Mark D.] Naval Special Warfare Human Performance Program, Virginia Beach, VA USA. [Kraemer, William J.] Ohio State Univ, Dept Human Sci, Coll Educ & Human Ecol, Columbus, OH 43210 USA. RP Nindl, BC (reprint author), Univ Pittsburgh, Sch Hlth & Rehabil Sci, Dept Sports Med & Nutr, Neuromuscular Res Lab,Warrior Human Performance R, Pittsburgh, PA USA. EM Bradley.c.nindl.civ@mail.mil NR 14 TC 1 Z9 1 U1 2 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1064-8011 EI 1533-4287 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD NOV PY 2015 VL 29 SU 11 BP S216 EP S220 PG 5 WC Sport Sciences SC Sport Sciences GA DN5KB UT WOS:000377104500037 PM 26506191 ER PT J AU Nindl, BC AF Nindl, Bradley C. TI PHYSICAL TRAINING STRATEGIES FOR MILITARY WOMEN'S PERFORMANCE OPTIMIZATION IN COMBAT-CENTRIC OCCUPATIONS SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Review DE periodized training; military performance; female combat occupations; training doctrine ID SPRINT INTERVAL; RESISTANCE; MUSCLE; CAPACITY AB The physiological differences, particularly of upper-body strength and power, between women and men, and the rigors of combat-centric occupational demands would seem to place women at a significant disadvantage, as the U.S. military opens up previously closed combat-arms military occupational specialties (MOSs) to women. This inherent disadvantage can be significantly mitigated by implementing effective and comprehensive physical training (PT) regimens for women targeting those fitness components most critical for those tasks considered most essential for solider war-fighting duties (i.e., strength and power). Regrettably, the military historical and legacy overemphasis on aerobic fitness and on "field expediency" as the major criteria for implementing training have limited the extent to which the military has fully operationalized state-of-the-science PT policies. This continued legacy approach could be problematic regarding fully enhancing women's abilities to perform physically demanding combat-centric occupations and could place the successful integration of women into ground combat MOSs at significant risk. Seminal studies from the literature indicate that (a) a minimum of 6 months of periodized combined resistance/endurance training preparedness is recommended for untrained women considering entering combat-arms MOS training; (b) any comprehensive PT program should incorporate and emphasize progressive load carriage training; (c) a greater emphasis on upper body on strength/power development in military women is needed; (d) heavy resistance training in the range of 3-8 repetition maximum sets should be incorporated into training programs to target type II motor units and muscle fibers (those fibers that produce the most force and have the greatest capacity to hypertrophy); (e) low-volume, high-intensity interval training should be considered as a time-efficient training method to improve aerobic fitness while protecting against lower-body musculoskeletal injuries; (f) flexible nonlinear periodized programs should be considered to best accommodate the unpredictability and operational functional needs of the military training environment; and (g) serious consideration should be given to revamping the manner in which the military conducts physical readiness training, with a departure from "field expediency" as the major criteria for determining PT policies. With an increased emphasis on the human dimension of soldiering and concerted strategic, operational, and tactical efforts to maximize individual physical readiness and performance, the science of training physiology exists to leverage and better physically prepare women as they enter more combat-centric occupations. C1 [Nindl, Bradley C.] Univ Pittsburgh, Warrior Human Performance Res Ctr, Neuromuscular Res Lab, Dept Sports Med & Nutr,Sch Hlth & Rehabil Sci, Pittsburgh, PA USA. [Nindl, Bradley C.] US Army, Publ Hlth Ctr Provis, Aberdeen Proving Ground, MD USA. RP Nindl, BC (reprint author), Univ Pittsburgh, Warrior Human Performance Res Ctr, Neuromuscular Res Lab, Dept Sports Med & Nutr,Sch Hlth & Rehabil Sci, Pittsburgh, PA USA. EM bradley.c.nindl.civ@mail.mil NR 21 TC 2 Z9 2 U1 6 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1064-8011 EI 1533-4287 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD NOV PY 2015 VL 29 SU 11 BP S101 EP S106 PG 6 WC Sport Sciences SC Sport Sciences GA DN5KB UT WOS:000377104500017 PM 26506171 ER PT J AU Nindl, BC Sharp, MA AF Nindl, Bradley C. Sharp, Marilyn A. TI THIRD INTERNATIONAL CONGRESS ON SOLDIERS' PHYSICAL PERFORMANCE: TRANSLATING STATE-OF-THE-SCIENCE SOLDIER RESEARCH FOR OPERATIONAL UTILITY SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Article AB Nindl, BC and Sharp, MA. Third International Congress on Soldiers' Physical Performance: translating state-of-the-science soldier research for operational utility. J Strength Cond Res 29(11S): S1-S3, 2015-The Third International Congress on Soldiers' Physical Performance (ICSPP) was held on August 18-21, 2014 in Boston, MA, where it had a record attendance of 374 registrants from 27 countries. The Congress included 8 invited keynote lectures, 12 symposia, 1 featured science session, more than 200 oral and poster free communication sessions, 8 thematic poster sessions, and a Warfighter Readiness Roundtable. Collectively, the presentations focused on a fundamental premise that soldiers are the center of warfighting capability, and the human service member is the prime resource and key enabler of all warfighting systems. The intent of the ICSPP series is to focus on the soldier-the individual service member. As we move forward with focus placed on the human dimension of soldiering, the key to our scientific success and what will prove to be transformative will be the extent to which we can operationalize and disseminate our scientific knowledge for the benefit of our soldiers on the ground. The Congress fostered important scientific exchange, and dialog centered on improving military physical performance and readiness. As countries around the globe respond to current and emerging threats to their national security, it is increasingly clear that we must ensure optimal human performance of our military personnel. By taking advantage of the science and applications of physical fitness and injury prevention research, we can leverage our increased understanding for the optimal application of physical readiness processes while minimizing the injury risk potential. We believe that the continued scientific and evidence-based dialog across international partners will prove to be transformative in identifying the most effective strategies for human performance optimization in the 21st century. Innovation, leveraging current state-of-the-science, and international partnerships were all key themes throughout the Congress. From the ICSPP scientific program, it was clear that there is abundant scientific knowledge on how to improve soldiers' sleep, activity, and nutrition and that a major challenge is for scientists and military leaders/policy makers to work together to operationalize what is known for soldier utility on the ground. C1 [Nindl, Bradley C.] Univ Pittsburgh, Sch Hlth & Rehabil Sci, Dept Sports Med & Nutr, Warrior Human Performance Res Ctr,Neuromuscular R, Pittsburgh, PA USA. [Nindl, Bradley C.] US Army, Publ Hlth Ctr Provis, Aberdeen Proving Ground, MD USA. [Sharp, Marilyn A.] US Army, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. RP Nindl, BC (reprint author), Univ Pittsburgh, Sch Hlth & Rehabil Sci, Dept Sports Med & Nutr, Warrior Human Performance Res Ctr,Neuromuscular R, Pittsburgh, PA USA. NR 0 TC 1 Z9 1 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1064-8011 EI 1533-4287 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD NOV PY 2015 VL 29 SU 11 BP S1 EP S3 PG 3 WC Sport Sciences SC Sport Sciences GA DN5KB UT WOS:000377104500001 PM 26506169 ER PT J AU Reilly, TJ Gebhardt, DL Billing, DC Greeves, JP Sharp, MA AF Reilly, Tara J. Gebhardt, Deborah L. Billing, Daniel C. Greeves, Julie P. Sharp, Marilyn A. TI DEVELOPMENT AND IMPLEMENTATION OF EVIDENCE-BASED PHYSICAL EMPLOYMENT STANDARDS: KEY CHALLENGES IN THE MILITARY CONTEXT SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Article DE physical fitness; fitness standards; Army; Navy; Air Force; fitness test AB The use of evidence-based physical employment standards is critical in selecting individuals who can meet the requirements of arduous military occupations. The methods used to generate the physical assessments and standards are critical to the process and must withstand legal scrutiny. This article addresses the challenges encountered when developing, validating, and implementing physical standards and assessments. The challenges covered by the study include: (a) identification of critical job tasks and minimum requirements for performance of the tasks, (b) involvement of military personnel as subject-matter experts, (c) development of tests and criterion measures linked to critical job tasks, (d) determination of test performance standards, (e) evaluation of bias for protected groups, and (f) implementation, development of test policies, and revision of tests and standards. C1 [Reilly, Tara J.] Canadian Forces Morale & Welf Serv, Human Performance Res & Dev, Ottawa, ON, Canada. [Gebhardt, Deborah L.] Human Performance Syst Inc, Beltsville, MD USA. [Billing, Daniel C.] Def Sci & Technol Org, Land Div, Melbourne, Vic, Australia. [Greeves, Julie P.] HQ Army Recruiting & Training Div, Dept Occupat Med, Pewsey, Wilts, England. [Sharp, Marilyn A.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. RP Reilly, TJ (reprint author), Canadian Forces Morale & Welf Serv, Human Performance Res & Dev, Ottawa, ON, Canada. EM tara.reilly@forces.gc.ca NR 12 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1064-8011 EI 1533-4287 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD NOV PY 2015 VL 29 SU 11 BP S28 EP S33 PG 6 WC Sport Sciences SC Sport Sciences GA DN5KB UT WOS:000377104500005 PM 26506194 ER PT J AU Seay, JF AF Seay, Joseph F. TI BIOMECHANICS OF LOAD CARRIAGE-HISTORICAL PERSPECTIVES AND RECENT INSIGHTS SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Review DE joint moments; kinematics; kinetics; knee mechanics; overuse injury ID MEDICAL ASPECTS; KINEMATICS; SOLDIERS; PELVIS; GAIT AB Loads carried by the warfighter have increased substantially throughout recorded history, with the typical U.S. ground soldier carrying external loads averaging 45 kg during operations in Afghanistan. Incidence of disability in the U.S. Army has also increased sixfold since the 1980s, predominantly driven by increases in musculoskeletal injuries, with load carriage implicated as a possible mechanism. This article will provide a brief overview of the biomechanics of load carriage and will provide some recent insights into how the stress of the loads carried by military personnel can affect the musculoskeletal system. Studies into the biomechanics of load carriage have documented motion-related differences such as increased step rate, decreased stride length, and more trunk lean with increases in pack-borne loads. However, there is a paucity of literature on the relationship between load carriage and biomechanical mechanisms of overuse injury. Findings of recent studies will be presented, which add mechanistic information to increased stresses on the lower extremity. This was particularly true at the knee, where in one study, peak knee extension moment increased 115% when carrying a 55 kg load (0.87 +/- 0.16 Nm.kg(-1)) vs. no external load (0.40 +/- 0.13 Nm.kg(-1)). Efforts to model injury mechanisms require continued biomechanical measurements in humans while carrying occupationally relevant loads to be validated. Specifically, imaging technologies (e.g., bone geometry scans) should be incorporated to produce higher fidelity model of the stresses and strains experienced by the load carrier. In addition to laboratory-based biomechanics, data are needed to further explore the mechanistic relationship between load magnitude and injury; to this end, wearable sensors should continue to be exploited to accurately quantify biomechanical stresses related to load carriage in the field. C1 [Seay, Joseph F.] US Army, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA. RP Seay, JF (reprint author), US Army, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA. EM joseph.f.seay.civ@mail.mil NR 18 TC 0 Z9 0 U1 3 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1064-8011 EI 1533-4287 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD NOV PY 2015 VL 29 SU 11 BP S129 EP S133 PG 5 WC Sport Sciences SC Sport Sciences GA DN5KB UT WOS:000377104500021 PM 26506175 ER PT J AU Taipale, RS Heinaru, S Nindl, BC Vaara, JP Santtila, M Hakkinen, K Kyrolainen, H AF Taipale, Ritva S. Heinaru, Siiri Nindl, Bradley C. Vaara, Jani P. Santtila, Matti Hakkinen, Keijo Kyrolainen, Heikki TI HORMONAL RESPONSES TO ACTIVE AND PASSIVE RECOVERY AFTER LOAD CARRIAGE SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Article DE military readiness; muscular strength; anaerobic intensity ID RESISTANCE EXERCISE; MEN AB Military operations often induce fatigue resulting from load carriage. Recovery promotes military readiness. This study investigated the acute effects of AR vs. PR after load carriage on maximal isometric leg extension force (MVC) and serum hormonal concentrations. Male reservists (27 +/- 0 3 years, 180 +/- 7 cm, 74 +/- 11 kg, (V) over dotO(2)max 64 +/- 9 ml.kg(-1).min(-1)) completed PR (n = 8) or AR (n = 8) after 50 minutes of loaded (16 kg) uphill (gradient 4.0%) treadmill marching at individual anaerobic threshold. No differences were observed between groups in relative changes in MVC during the marching loading, after AR or PR or the next morning. Significant differences in relative responses to AR and PR postmarching loading were observed in serum testosterone (T), cortisol, and sex-hormone binding globulin immediately post AR and PR; however the next morning, all serum hormone concentrations had returned to normal. This study did not reveal any significant differences between the effects of AR and PR after an hour-long marching protocol at approximately anaerobic threshold on MVC or serum hormones the morning after the experimental marching protocol. Thus, based on the variable measured in this study, marching performed by physically fit army reservists at an intensity at or below anaerobic threshold may not necessitate specialized recovery protocols. C1 [Taipale, Ritva S.; Heinaru, Siiri; Vaara, Jani P.; Hakkinen, Keijo; Kyrolainen, Heikki] Univ Jyvaskyla, Dept Biol Phys Act, SF-40100 Jyvaskyla, Finland. [Nindl, Bradley C.] Univ Pittsburgh, Neuromuscular Res Lab, Warrior Human Performance Res Ctr, Dept Sports Med & Nutr,Sch Hlth & Rehabil Sci, Pittsburgh, PA USA. [Nindl, Bradley C.] US Army, Publ Hlth Ctr Provis, Aberdeen Proving Ground, MD USA. [Vaara, Jani P.; Kyrolainen, Heikki] Natl Def Univ, Helsinki, Finland. [Santtila, Matti] Def Command, Personnel Div, Helsinki, Finland. RP Taipale, RS (reprint author), Univ Jyvaskyla, Dept Biol Phys Act, SF-40100 Jyvaskyla, Finland. EM ritva.taipale@jyu.fi FU University of Jyvaskyla; Department of Biology of Physical Activity; Finnish Defense Forces FX The present study was completed in co-operation of the Department of Biology of Physical Activity, University of Jyvaskyla, Jyvaskyla, Finland, and the Finnish Defense Forces. Funding was provided by the University of Jyvaskyla, the Department of Biology of Physical Activity, and the Finnish Defense Forces. The authors wish to thank the technical staff of the Department of Biology of Physical Activity, statistical advisor Elina Vaara, our many devoted students, and highly motivated subjects, who donated their time and energy for successful data collection. NR 15 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1064-8011 EI 1533-4287 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD NOV PY 2015 VL 29 SU 11 BP S149 EP S153 PG 5 WC Sport Sciences SC Sport Sciences GA DN5KB UT WOS:000377104500025 PM 26506179 ER PT J AU Parr, JJ Clark, NC Abt, JP Kresta, JY Keenan, KA Kane, SF Lephart, SM AF Parr, Jeffrey J. Clark, Nicholas C. Abt, John P. Kresta, Julie Y. Keenan, Karen A. Kane, Shawn F. Lephart, Scott M. TI Residual Impact of Previous Injury on Musculoskeletal Characteristics in Special Forces Operators SO ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE LA English DT Article DE muscle injury; residual; performance; injury prevention; military ID AIR-DISPLACEMENT PLETHYSMOGRAPHY; JUNIOR TENNIS PLAYERS; LOW-BACK-PAIN; BODY-COMPOSITION; MUSCLE STRENGTH; SOCCER PLAYERS; FLEXIBILITY; RELIABILITY; SHOULDER; MOTION AB Background: Musculoskeletal injuries are a significant burden to United States Army Special Operations Forces. The advanced tactical skill level and physical training required of Army Special Operators highlights the need to optimize musculoskeletal characteristics to reduce the likelihood of suffering a recurrent injury. Purpose: To identify the residual impact of previous injury on musculoskeletal characteristics. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Isokinetic strength of the knee, shoulder, and back and flexibility of the shoulder and hamstrings were assessed as part of a comprehensive human performance protocol, and self-reported musculoskeletal injury history was obtained. Subjects were stratified based on previous history of low back, knee, or shoulder injury, and within-group and between-group comparisons were made for musculoskeletal variables. Results: Knee injury analysis showed no significant strength or flexibility differences. Shoulder injury analysis found internal rotation strength of the healthy subjects (H) was significantly higher compared with injured (I) and uninjured (U) limbs of the injured group (H, 60.8 +/- 11.5 percent body weight [%BW]; I, 54.5 +/- 10.5 % BW; U, 55.5 +/- 11.3 % BW) (P = .014 [H vs I] and P = .05 [H vs U]). The external rotation/internal rotation strength ratio was significantly lower in the healthy subjects compared with injured and uninjured limbs of the injured group (H, 0.653 +/- 0.122; I, 0.724 +/- 0.121; U, 0.724 +/- 0.124) (P = .026 [H vs I] and P = .018 [H vs U]). Posterior shoulder tightness was significantly different between the injured and uninjured limb of the injured group (I, 111.6 degrees +/- 9.4 degrees; U, 114.4 degrees +/- 9.3 degrees; P = .008). The back injury analysis found no significant strength differences between the healthy and injured groups. Conclusion: Few physical differences existed between operators with prior knee or back injury. However, operators with a previous history of shoulder injury demonstrated significantly less shoulder strength than uninjured operators as well as decreased shoulder flexibility on the injured side. All operators, regardless of prior injury, must perform the same tasks; therefore, a targeted injury rehabilitation/human performance training specifically focused on internal rotation strength and tightness of the posterior capsule may help reduce the risk for recurrence of injury. Operators presenting with musculoskeletal asymmetries and/or insufficient strength ratios may be predisposed to musculoskeletal injury. Clinical Relevance: Specific fitness programs to compensate for deficiencies in strength and flexibility need to be designed that may reduce the risk of injuries in Special Forces Operators. C1 [Parr, Jeffrey J.; Clark, Nicholas C.; Abt, John P.; Kresta, Julie Y.; Keenan, Karen A.; Kane, Shawn F.; Lephart, Scott M.] Warrior Human Performance Lab, Ft Bragg, NC USA. RP Parr, JJ (reprint author), Univ Pittsburgh, Neuromuscular Res Lab, 3830 South Water St, Pittsburgh, PA 15203 USA. EM jparr@pitt.edu NR 45 TC 0 Z9 0 U1 2 U2 2 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 2325-9671 J9 ORTHOP J SPORTS MED JI Orthop. J. Sports Med. PD NOV PY 2015 VL 3 IS 11 DI 10.1177/2325967115616581 PG 7 WC Sport Sciences SC Sport Sciences GA DE2AA UT WOS:000370427200004 ER PT J AU Rutstein, SE Sellers, CJ Ananworanich, J Cohen, MS AF Rutstein, Sarah E. Sellers, Christopher J. Ananworanich, Jintanat Cohen, Myron S. TI The HIV treatment cascade in acutely infected people: informing global guidelines SO CURRENT OPINION IN HIV AND AIDS LA English DT Review DE acute HIV infection; guidelines; HIV cascade; HIV diagnostics; linkage to care ID ADULTS SEEKING CARE; SUB-SAHARAN AFRICA; CD4(+) T-CELLS; ANTIRETROVIRAL THERAPY; COASTAL KENYA; HIV-1-INFECTED INDIVIDUALS; FIELD-EVALUATION; RESERVOIR SIZE; UNITED-STATES; OPEN-LABEL AB Purpose of review Acute and early HIV (AHI) is a pivotal time during HIV infection, yet there remain major shortfalls in diagnosis, linkage to care, and antiretroviral therapy (ART) initiation during AHI. We introduce an AHI-specific cascade, review recent evidence pertaining to the unique challenges of AHI, and discuss strategies for improving individual and public health outcomes. Recent findings Presentation during AHI is common. Expanding use of fourth-generation testing and pooled nucleic acid amplification testing has led to improved AHI detection in resource-wealthy settings. Technologies capable of AHI diagnosis are rare in resource-limited settings; further development of point-of-care devices and utilization of targeted screening is needed. Rapid ART initiation during AHI limits reservoir seeding, preserves immunity, and prevents transmission. Reporting of AHI cascade outcomes is limited, but new evidence suggests that impressive rates of diagnosis, linkage to care, rapid ART initiation, and viral suppression can be achieved. Summary With advancements in AHI diagnostics and strong evidence for the therapeutic and prevention benefits of ART initiated during AHI, improving AHI cascade outcomes is both crucial and feasible. HIV guidelines should recommend diagnostic algorithms capable of detecting AHI and prescribe rapid, universal ART initiation during AHI. C1 [Rutstein, Sarah E.] Univ N Carolina, Dept Hlth Policy & Management, CB 7411, Chapel Hill, NC 27599 USA. [Rutstein, Sarah E.; Sellers, Christopher J.; Cohen, Myron S.] Univ N Carolina, Div Infect Dis, Chapel Hill, NC USA. [Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Cohen, Myron S.] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA. RP Rutstein, SE (reprint author), Univ N Carolina, Dept Hlth Policy & Management, CB 7411, Chapel Hill, NC 27599 USA. EM sarah_rutstein@med.unc.edu FU UNC Center for AIDS Research, an NIH funded program [P30 AI50410]; National Institutes of Health [NIMH-F30 MH098731, NIGMS-T32 GM008719, NIAID-R01 AI114320, NIAID-5T32AI070114-08] FX This work was supported by the UNC Center for AIDS Research, an NIH funded program (P30 AI50410). National Institutes of Health supported Sarah E. Rutstein (NIMH-F30 MH098731, NIGMS-T32 GM008719, and NIAID-R01 AI114320) and Christopher J. Sellers (NIAID-5T32AI070114-08). J. A. has received honorarium from Merck and ViiV Healthcare. NR 98 TC 2 Z9 2 U1 3 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1746-630X EI 1746-6318 J9 CURR OPIN HIV AIDS JI Curr. Opin. HIV AIDS PD NOV PY 2015 VL 10 IS 6 BP 395 EP 402 DI 10.1097/COH.0000000000000193 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA DD1YI UT WOS:000369718800002 PM 26371460 ER PT J AU Hussein, M Renner, M Iagnemma, K AF Hussein, Marwan Renner, Matthew Iagnemma, Karl TI Global Localization of Autonomous Robots in Forest Environments SO PHOTOGRAMMETRIC ENGINEERING AND REMOTE SENSING LA English DT Article AB A method for the autonomous geolocation of ground vehicles in forest environments is presented. The method provides an estimate of the global horizontal position of a vehicle strictly based on finding a geometric match between a map of observed tree stems, scanned in 3D by Light Detection and Ranging (lidar) sensors onboard the vehicle, to another stem map generated from the structure of tree crowns analyzed from high resolution aerial orthoimagery of the forest canopy. The method has been tested with real-world data and has been able to estimate vehicle geoposition with an average error of less than 2 m. The method has two key properties that are significant: (a) The algorithm does not require a priori knowledge of the area surrounding the robot, and (b) Based on estimated vehicle state, it uses the geometry of detected tree stems as the only input to determine horizontal geoposition. C1 [Hussein, Marwan; Iagnemma, Karl] MIT, Robot Mobil Grp, 77 Massachusetts Ave, Cambridge, MA 02139 USA. [Renner, Matthew] US Army, Engineer Res & Dev Ctr, Alexandria, VA 22315 USA. RP Hussein, M (reprint author), MIT, Robot Mobil Grp, 77 Massachusetts Ave, Cambridge, MA 02139 USA. EM marwan.hussein@sloan.mit.edu NR 14 TC 0 Z9 0 U1 2 U2 3 PU AMER SOC PHOTOGRAMMETRY PI BETHESDA PA 5410 GROSVENOR LANE SUITE 210, BETHESDA, MD 20814-2160 USA SN 0099-1112 J9 PHOTOGRAMM ENG REM S JI Photogramm. Eng. Remote Sens. PD NOV PY 2015 VL 81 IS 11 BP 839 EP 846 PG 8 WC Geography, Physical; Geosciences, Multidisciplinary; Remote Sensing; Imaging Science & Photographic Technology SC Physical Geography; Geology; Remote Sensing; Imaging Science & Photographic Technology GA DD2UU UT WOS:000369778500004 ER PT J AU Sang, LP Surls, J Mendoza, M Casares, S Brumeanu, T AF Sang, Luis Pow Surls, Jacqueline Mendoza, Mirian Casares, Sofia Brumeanu, Teodor TI HLA-DR*0401 expression in the NOD mice prevents the development of autoimmune diabetes by multiple alterations in the T-cell compartment SO CELLULAR IMMUNOLOGY LA English DT Article DE NOD humanized mice; HLA-DR*0401; Type 1 diabetes; T-cell regulation ID MHC CLASS-II; HLA CLASS-II; TRANSGENIC MICE; GENETIC-CONTROL; HUMAN CD4; MOLECULES; MOUSE; RATIO; RECEPTOR; PEPTIDE AB Several human HLA alleles have been found associated with type 1 diabetes (T1D), but their precise role is not clearly defined. Herein, we report that a human MHC class II (HLA-DR*0401) allele transgene that has been expressed into NOD (H-2(g7)I-E-null) mice prone to T1D rendered the mice resistant to the disease. T1D resistance occurred in the context of multi-point T-cell alterations such as: (i) skewed CD4/CD8 T-cell ratio, (ii) decreased size of CD4(+)CD44(high) T memory pool, (iii) aberrant TCR V beta repertoire, (iv) increased neonatal number of Foxp3(+) and TR-1(+) regulatory cells, and (v) reduced IFN-gamma inflammatory response vs. enhanced IL-10 suppressogenic response of T-cells upon polyclonal and antigen-specific stimulation. The T-cells from NOD/DR4 Tg mice were unable to induce or suppress diabetes in NOD/RAG deficient mice. This study describes a multifaceted regulatory function of the HLA-DR*0401 allele strongly associated with the lack of T1D development in NOD mice. Published by Elsevier Inc. C1 [Sang, Luis Pow; Surls, Jacqueline; Mendoza, Mirian; Casares, Sofia; Brumeanu, Teodor] Uniformed Serv Univ Hlth Sci, Dept Med, Div Immunol, Bldg A,Rooms A3074-3072, Bethesda, MD 20814 USA. [Casares, Sofia] Naval Med Res Ctr, Walter Reed Army Inst Res, Infect Dis Directorate, Malaria Program, Silver Spring, MD 20910 USA. RP Brumeanu, T (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med, Div Immunol, Bldg A,Rooms A3074-3072, Bethesda, MD 20814 USA. EM teodor-doru.brumeanu@usuhs.edu FU USUHS [RO83ZK]; JDRF FX This work was supported by an USUHS Grant RO83ZK to TDB, and a JDRF Grant to TDB and SC. We thank Ms. Margaret Kehl for assistance with FACS analyses. NR 46 TC 0 Z9 0 U1 1 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0008-8749 EI 1090-2163 J9 CELL IMMUNOL JI Cell. Immunol. PD NOV-DEC PY 2015 VL 298 IS 1-2 BP 54 EP 65 DI 10.1016/j.cellimm.2015.09.003 PG 12 WC Cell Biology; Immunology SC Cell Biology; Immunology GA DC4CU UT WOS:000369168400008 ER PT J AU Pacha, LA Hakre, S Myles, O Sanders-Buell, EE Scoville, SL Kijak, GH Price, MW Mody, RM Liu, Y Miller, SL Pham, PT Michael, NL Kim, JH Peel, SA Tovanabutra, S Jagodzinski, LL Cersovsky, SB Scott, PT AF Pacha, Laura A. Hakre, Shilpa Myles, Otha Sanders-Buell, Eric E. Scoville, Stephanie L. Kijak, Gustavo H. Price, Michael W. Mody, Rupal M. Liu, Ying Miller, Shana L. Pham, Phuc T. Michael, Nelson L. Kim, Jerome H. Peel, Sheila A. Tovanabutra, Sodsai Jagodzinski, Linda L. Cersovsky, Steven B. Scott, Paul T. TI Centralized HIV Program Oversight: An Investigation of a Case Series of New HIV Infections among US Army Soldiers, 2012 to 2013 SO MEDICINE LA English DT Article ID UNITED-STATES; MARINE CORPS; TRANSMISSION; SEQUENCES; HEALTH; NAVY; EPIDEMIOLOGY; SURVEILLANCE; MSM AB Centralized HIV program oversight and repeal of the Department of Defense policy Don't Ask Don't Tell permitted characterization of HIV transmission among soldiers assigned to a large US Army base in the continental United States from 2012 to 2013. An investigation of a greater than expected number of new HIV infections among soldiers was initiated to characterize transmission and identify opportunities to disrupt transmission and deliver services.All soldiers who were assigned to the base at the time of their first positive HIV test and who had their first positive HIV test in 2012 or in the first 6 months of 2013 and who had a clinical genotype available for analysis were eligible for inclusion in the investigation.All patients (n=19) were men; most were black (52%) and less than 30 years old (64%). Fifteen of the 19 patients participated in in-depth interviews. Eighty percent were men who have sex with men who reported multiple sex partners having met through social and electronic networks. All were subtype B infections. Significant knowledge gaps and barriers to accessing testing and care in the military healthcare system were identified. Most (58%) belonged to transmission networks involving other soldiers.This investigation represents an important step forward in on-going efforts to develop a comprehensive understanding of transmission networks in the Army that can inform delivery of best practices combination prevention services. The Army is developing plans to directly engage individuals in key affected populations most at risk for HIV infection to identify and address unmet needs and expand delivery and uptake of prevention services. Further investigation is underway and will determine whether these findings are generalizable to the Army. C1 [Pacha, Laura A.; Scoville, Stephanie L.; Cersovsky, Steven B.] US Army Publ Hlth Command, Aberdeen Proving Ground, Bethesda, MD USA. [Hakre, Shilpa; Myles, Otha; Sanders-Buell, Eric E.; Kijak, Gustavo H.; Liu, Ying; Miller, Shana L.; Pham, Phuc T.; Tovanabutra, Sodsai] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Bethesda, MD USA. [Price, Michael W.; Mody, Rupal M.] US Army Med Command, San Antonio, TX USA. [Michael, Nelson L.; Kim, Jerome H.; Peel, Sheila A.; Jagodzinski, Linda L.; Scott, Paul T.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. RP Scott, PT (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Epidemiol & Threat Assessment, 6720A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA. EM pscott@hivresearch.org FU OCONUS Contingency Operations funds from the United States Department of Defense FX This work was supported by OCONUS Contingency Operations funds from the United States Department of Defense. NR 28 TC 0 Z9 0 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0025-7974 EI 1536-5964 J9 MEDICINE JI Medicine (Baltimore) PD NOV PY 2015 VL 94 IS 46 AR e2093 DI 10.1097/MD.0000000000002093 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA DC9JU UT WOS:000369538500027 PM 26579822 ER PT J AU Cilli, M Parnell, GS Cloutier, R Zigh, T AF Cilli, Matthew Parnell, Gregory S. Cloutier, Robert Zigh, Teresa TI A Systems Engineering Perspective on the Revised Defense Acquisition System SO SYSTEMS ENGINEERING LA English DT Article DE better buying power; defense acquisition system; new product development; systemigram; conceptagon; systems thinking; systems engineering trade-off analyses; affordability AB The U.S. Department of Defense (DoD) has recently revised the defense acquisition system to address suspected root causes hindering higher success rates. This article applies two systems thinking methodologies in a uniquely integrated fashion to provide an in-depth review and compelling interpretation of the revised defense acquisition system as put forth in January 7, 2015 DoDI 5000.02. Changes from the previous defense acquisition system are significant and may be cause for some cautious optimism in the United States. This article describes how the architects of the revised defense acquisition system have increased emphasis on systems engineering activities applied early in the lifecycle so that meaningful trade-offs between capability requirements and lifecycle costs can be explored as requirements are being written to ensure realistic program baselines are established such that associated lifecycle costs will likely fit within future budgets. Expressed as emerging systems engineering research questions, this article identifies several gaps that are likely to emerge as the defense acquisition community attempts to execute the new acquisition system. (C) 2016 Wiley Periodicals, Inc. C1 [Cilli, Matthew] US Army, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ USA. [Parnell, Gregory S.] Univ Arkansas, Coll Engn, Fayetteville, AR 72701 USA. [Cloutier, Robert; Zigh, Teresa] Stevens Inst Technol, Sch Syst & Enterprises, Hoboken, NJ 07030 USA. RP Cilli, M (reprint author), US Army, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ USA. EM matthew.v.cilli.civ@mail.mil; greg.parnell@gmail.com; robert.cloutier@stevens.edu; tzigh@stevens.edu NR 23 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1098-1241 EI 1520-6858 J9 SYSTEMS ENG JI Syst. Eng. PD NOV PY 2015 VL 18 IS 6 BP 584 EP 603 DI 10.1002/sys.21329 PG 20 WC Engineering, Industrial; Operations Research & Management Science SC Engineering; Operations Research & Management Science GA DC4AA UT WOS:000369160700003 ER PT J AU Ghazi, IM Crandon, JL Lesho, EP McGann, P Nicolau, DP AF Ghazi, Islam M. Crandon, Jared L. Lesho, Emil P. McGann, Patrick Nicolau, David P. TI Efficacy of Humanized High-Dose Meropenem, Cefepime, and Levofloxacin against Enterobacteriaceae Isolates Producing Verona Integron-Encoded Metallo-beta-Lactamase (VIM) in a Murine Thigh Infection Model SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID IN-VIVO ACTIVITIES; KLEBSIELLA-PNEUMONIAE; STREPTOCOCCUS-PNEUMONIAE; CARBAPENEM; CEFTAZIDIME; ERTAPENEM; REGIMENS; THERAPY; IMPACT AB We aimed to describe the in vivo activity of humanized pharmacokinetic exposures of meropenem and comparators against Verona integron-encoded metallo-beta-lactamase (MBL) (VIM)-producing Enterobacteriaceae in a murine model. Levofloxacin activity was predicted by its MIC, and cefepime activity displayed variability, whereas meropenem produced a >1 log CFU reduction against all isolates despite high MICs indicative of resistance. Our results suggest that despite in vitro resistance, high-dose meropenem may be a possible option against infections caused by Enterobacteriaceae producing MBL-type carbapenemases. C1 [Ghazi, Islam M.; Crandon, Jared L.; Nicolau, David P.] Hartford Hosp, Ctr Antiinfect Res & Dev, Hartford, CT 06115 USA. [Lesho, Emil P.; McGann, Patrick] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD USA. [Nicolau, David P.] Hartford Hosp, Div Infect Dis, Hartford, CT 06115 USA. RP Nicolau, DP (reprint author), Hartford Hosp, Ctr Antiinfect Res & Dev, Hartford, CT 06115 USA. EM david.nicolau@hhchealth.org OI Ghazi, Islam/0000-0003-1108-7706 FU Center for Anti-Infective Research and Development at Hartford Hospital FX This study was conducted using internal funding from the Center for Anti-Infective Research and Development at Hartford Hospital. NR 19 TC 3 Z9 3 U1 1 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD NOV PY 2015 VL 59 IS 11 BP 7145 EP 7147 DI 10.1128/AAC.00794-15 PG 3 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA DB0ZR UT WOS:000368238100066 PM 26416855 ER PT J AU Cardile, AP Mayers, DL Bavari, S AF Cardile, A. P. Mayers, D. L. Bavari, S. TI EMERGING OPTIONS IN DEVELOPMENT FOR TREATMENT OF FILOVIRUS INFECTIONS SO DRUGS OF THE FUTURE LA English DT Review DE Ebola; Marburg; BCX-4433; Brincidofovir; Favipiravir; Small-interfering RNAs; Antisense phosphorodiamidate; Morpholino oligomers; Interferon; FX-06; zMapp; Recombinant nematode anticoagulant protein c2; Convalescent plasma; Amodiaquine ID EBOLA-VIRUS DISEASE; NONHUMAN-PRIMATES; MARBURG VIRUS; RNA INTERFERENCE; HEMORRHAGIC-FEVER; CONVALESCENT PLASMA; FAVIPIRAVIR T-705; POSTEXPOSURE PROTECTION; NUCLEOSIDE ANALOG; HAMSTER MODEL AB As a result of the ongoing Ebola outbreak in West Africa, there have been significant developments in therapeutics against Filovirus over the past year. Not only have novel therapeutics been advanced, but a number of already-approved drugs have demonstrated activity against Ebola virus. This review article summarizes the most important therapeutic agents for both Ebola and Marburg virus. Among the therapeutics discussed, small-molecule inhibitors, nucleic acid-based therapeutics, immune-therapeutics (zMapp, convalescent plasma) and repurposed drugs are all included. C1 [Cardile, A. P.] US Army Med Res, Inst Infect Dis, Div Med, Frederick, MD 21702 USA. [Mayers, D. L.] US Army Med Res, Inst Infect Dis, Therapeut Dev Ctr, Frederick, MD 21702 USA. [Bavari, S.] US Army Med Res, Inst Infect Dis, Frederick, MD 21702 USA. RP Cardile, AP (reprint author), US Army Med Res, Inst Infect Dis, Div Med, 1425 Porter St, Frederick, MD 21702 USA. EM anthony.p.cardile.mil@mail.mil FU U.S. Defense Threat Reduction Agency; Medical Countermeasures Systems FX The authors would like to acknowledge funding from the U.S. Defense Threat Reduction Agency and Medical Countermeasures Systems. NR 100 TC 1 Z9 1 U1 2 U2 6 PU PROUS SCIENCE, SAU-THOMSON REUTERS PI BARCELONA PA 398 PROVENCA, 08025 BARCELONA, SPAIN SN 0377-8282 EI 2013-0368 J9 DRUG FUTURE JI Drug Future PD NOV PY 2015 VL 40 IS 11 BP 727 EP 738 DI 10.1358/dof.2015.040.11.2387219 PG 12 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA DB3MQ UT WOS:000368416100003 ER PT J AU Nutter, E Meyer, S Shaw-Battista, J Marowitz, A AF Nutter, Elizabeth Meyer, Shaunette Shaw-Battista, Jenna Marowitz, Amy TI Waterbirth: An Integrative Analysis of Peer-Reviewed Literature Reply SO JOURNAL OF MIDWIFERY & WOMENS HEALTH LA English DT Letter C1 [Nutter, Elizabeth] MAJ US Army, Ft Hood, TX 76544 USA. [Meyer, Shaunette] US Army, US Army OB GYN Nursing Program, Ft Hood, TX USA. [Meyer, Shaunette] Univ Colorado, Denver, CO 80202 USA. [Shaw-Battista, Jenna] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Marowitz, Amy] Frontier Nursing Univ, Maple City, MI USA. RP Nutter, E (reprint author), MAJ US Army, Ft Hood, TX 76544 USA. NR 3 TC 0 Z9 0 U1 2 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1526-9523 EI 1542-2011 J9 J MIDWIFERY WOM HEAL JI J. Midwifery Women Health PD NOV-DEC PY 2015 VL 60 IS 6 BP 787 EP 788 DI 10.1111/jmwh.12401 PG 2 WC Nursing SC Nursing GA DB2KT UT WOS:000368338000026 PM 26613262 ER PT J AU Cho, JH Chan, K Adali, S AF Cho, Jin-Hee Chan, Kevin Adali, Sibel TI A Survey on Trust Modeling SO ACM COMPUTING SURVEYS LA English DT Article DE Modeling; Human Factors; Algorithms; Networks; Trust modeling; trust; trustor; trustee; decision making; composite trust ID MANAGEMENT FRAMEWORK; HUMAN INTERVENTION; SOCIAL TRUST; DATA FUSION; CENTRALITY; INFORMATION; SYSTEMS; BETWEENNESS; NETWORKS; WEB AB The concept of trust and/or trust management has received considerable attention in engineering research communities as trust is perceived as the basis for decision making in many contexts and the motivation for maintaining long-term relationships based on cooperation and collaboration. Even if substantial research effort has been dedicated to addressing trust-based mechanisms or trust metrics (or computation) in diverse contexts, prior work has not clearly solved the issue of how to model and quantify trust with sufficient detail and context-based adequateness. The issue of trust quantification has become more complicated as we have the need to derive trust from complex, composite networks that may involve four distinct layers of communication protocols, information exchange, social interactions, and cognitive motivations. In addition, the diverse application domains require different aspects of trust for decision making such as emotional, logical, and relational trust. This survey aims to outline the foundations of trust models for applications in these contexts in terms of the concept of trust, trust assessment, trust constructs, trust scales, trust properties, trust formulation, and applications of trust. We discuss how different components of trust can be mapped to different layers of a complex, composite network; applicability of trust metrics and models; research challenges; and future work directions. C1 [Cho, Jin-Hee; Chan, Kevin] US Army Res Lab, Adelphi, MD USA. [Adali, Sibel] Rensselaer Polytech Inst, Dept Comp Sci, Troy, NY 12180 USA. RP Cho, JH (reprint author), US Army Res Lab, Adelphi, MD USA. EM jin-hee.cho.civ@mail.mil; kevin.s.chan.civ@mail.mil; sibel@cs.rpi.edu FU Army Research Laboratory [W911NF-09-2-0053]; Department of Defense (DoD) through the Office of the Assistant Secretary of Defense for Research and Engineering (ASD(RE) FX Research was in part sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-09-2-0053. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation here on. This research was also partially supported by the Department of Defense (DoD) through the Office of the Assistant Secretary of Defense for Research and Engineering (ASD(R&E)). The views and opinions of the author(s) do not reflect those of the DoD nor ASD(R&E). NR 194 TC 3 Z9 3 U1 12 U2 33 PU ASSOC COMPUTING MACHINERY PI NEW YORK PA 2 PENN PLAZA, STE 701, NEW YORK, NY 10121-0701 USA SN 0360-0300 EI 1557-7341 J9 ACM COMPUT SURV JI ACM Comput. Surv. PD NOV PY 2015 VL 48 IS 2 AR 28 DI 10.1145/2815595 PG 40 WC Computer Science, Theory & Methods SC Computer Science GA DA8UJ UT WOS:000368081600012 ER PT J AU Light, B Perovich, DK Webster, MA Polashenski, C Dadic, R AF Light, Bonnie Perovich, Donald K. Webster, Melinda A. Polashenski, Christopher Dadic, Ruzica TI Optical properties of melting first-year Arctic sea ice SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID RADIATIVE-TRANSFER; ENERGY BUDGET; OCEAN; MODEL; ATMOSPHERE; COVER; LIGHT; PONDS AB The albedo and transmittance of melting, first-year Arctic sea ice were measured during two cruises of the Impacts of Climate on the Eco-Systems and Chemistry of the Arctic Pacific Environment (ICESCAPE) project during the summers of 2010 and 2011. Spectral measurements were made for both bare and ponded ice types at a total of 19 ice stations in the Chukchi and Beaufort Seas. These data, along with irradiance profiles taken within boreholes, laboratory measurements of the optical properties of core samples, ice physical property observations, and radiative transfer model simulations are employed to describe representative optical properties for melting first-year Arctic sea ice. Ponded ice was found to transmit roughly 4.4 times more total energy into the ocean, relative to nearby bare ice. The ubiquitous surface-scattering layer and drained layer present on bare, melting sea ice are responsible for its relatively high albedo and relatively low transmittance. Light transmittance through ponded ice depends on the physical thickness of the ice and the magnitude of the scattering coefficient in the ice interior. Bare ice reflects nearly three-quarters of the incident sunlight, enhancing its resiliency to absorption by solar insolation. In contrast, ponded ice absorbs or transmits to the ocean more than three-quarters of the incident sunlight. Characterization of the heat balance of a summertime ice cover is largely dictated by its pond coverage, and light transmittance through ponded ice shows strong contrast between first-year and multiyear Arctic ice covers. C1 [Light, Bonnie; Webster, Melinda A.] Univ Washington, Appl Phys Lab, Polar Sci Ctr, Seattle, WA 98105 USA. [Perovich, Donald K.; Polashenski, Christopher] US Army, Cold Reg Res & Engn Lab, Hanover, NH USA. [Webster, Melinda A.] Univ Washington, Sch Oceanog, Seattle, WA 98195 USA. [Dadic, Ruzica] Univ Washington, Dept Atmospher Sci, Seattle, WA 98195 USA. RP Light, B (reprint author), Univ Washington, Appl Phys Lab, Polar Sci Ctr, Seattle, WA 98105 USA. EM bonnie@apl.washington.edu FU NASA Impacts of Climate change on the Ecosystems and Chemistry of the Arctic Pacific Environment (ICESCAPE) project; NASA Cryospheric Sciences Program [NNH10A017I]; NASA Ocean Biology and Biogeochemistry Program; NASA [NNX14AH61G] FX The data for this paper are archived at NASA's Ocean Biology Processing Group repository (SeaBASS) http://seabass.gsfc.nasa.gov/seabasscgi/archive.cgi?q=CRREL/perovich/ice scape. We thank K. Colburn for her capable assistance handling the data. This research was supported by the NASA Impacts of Climate change on the Ecosystems and Chemistry of the Arctic Pacific Environment (ICESCAPE) project with support from the NASA Cryospheric Sciences Program (grant NNH10A017I to D. Perovich and B. Light) and the NASA Ocean Biology and Biogeochemistry Program. Subcontract to the University of Washington from NASA parent grant NNX14AH61G to K. Frey, Clark University is gratefully acknowledged. This work would not have been possible without the capable and professional support of the USCGC Healy crew during two field seasons of the ICESCAPE project. Comments from S. Hudson and one anonymous reviewer helped to improve this paper. NR 36 TC 4 Z9 4 U1 5 U2 17 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-9275 EI 2169-9291 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD NOV PY 2015 VL 120 IS 11 BP 7657 EP 7675 DI 10.1002/2015JC011163 PG 19 WC Oceanography SC Oceanography GA DA3GZ UT WOS:000367686500031 ER PT J AU Glover, MP Beaman, LA Berry-Caban, CS AF Glover, Michelle P. Beaman, Lindsey A. Berry-Caban, Cristobal S. TI Acinetobacter baumannii Hallux Infection Secondary to Partial Amputation in a US Soldier A Case Report SO JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION LA English DT Letter C1 [Glover, Michelle P.] Blanchfield Army Community Hosp, Ft Campbell, KY USA. [Beaman, Lindsey A.] Womack Army Med Ctr, Henry M Jackson Fdn, Ft Bragg, NC USA. [Beaman, Lindsey A.; Berry-Caban, Cristobal S.] Womack Army Med Ctr, Dept Clin Invest, Ft Bragg, NC USA. RP Glover, MP (reprint author), Landstuhl Reg Med Ctr, Landstuhl, Germany. EM michelle.p.glover.mil@mail.mil NR 4 TC 0 Z9 0 U1 0 U2 0 PU AMER PODIATRIC MED ASSOC PI BETHESDA PA 9312 OLD GEORGETOWN ROAD, BETHESDA, MD 20814-1621 USA SN 8750-7315 EI 1930-8264 J9 J AM PODIAT MED ASSN JI J. Am. Podiatr. Med. Assoc. PD NOV-DEC PY 2015 VL 105 IS 6 BP 560 EP 563 PG 4 WC Orthopedics SC Orthopedics GA DA3EM UT WOS:000367679500012 PM 26667510 ER PT J AU Gebhardt, MJ Gallagher, LA Jacobson, RK Usacheva, EA Peterson, LR Zurawski, DV Shuman, HA AF Gebhardt, Michael J. Gallagher, Larry A. Jacobson, Rachael K. Usacheva, Elena A. Peterson, Lance R. Zurawski, Daniel V. Shuman, Howard A. TI Joint Transcriptional Control of Virulence and Resistance to Antibiotic and Environmental Stress in Acinetobacter baumannii SO MBIO LA English DT Article ID IRON ACQUISITION FUNCTIONS; GALLERIA-MELLONELLA; MYCOBACTERIUM-TUBERCULOSIS; PSEUDOMONAS-AERUGINOSA; BIOFILM FORMATION; OXIDATIVE STRESS; IN-VIVO; PATHOGEN; PROTEIN; SULFUR AB The increasing emergence of antibiotic-resistant bacterial pathogens represents a serious risk to human health and the entire health care system. Many currently circulating strains of Acinetobacter baumannii exhibit resistance to multiple antibiotics. A key limitation in combating A. baumannii is that our understanding of the molecular mechanisms underlying the pathogenesis of A. baumannii is lacking. To identify potential virulence determinants of a contemporary multidrug-resistant isolate of A. baumannii, we used transposon insertion sequencing (TnSeq) of strain AB5075. A collection of 250,000 A. baumannii transposon mutants was analyzed for growth within Galleria mellonella larvae, an insect-based infection model. The screen identified 300 genes that were specifically required for survival and/or growth of A. baumannii inside G. mellonella larvae. These genes encompass both known, established virulence factors and several novel genes. Among these were more than 30 transcription factors required for growth in G. mellonella. A subset of the transcription factors was also found to be required for resistance to antibiotics and environmental stress. This work thus establishes a novel connection between virulence and resistance to both antibiotics and environmental stress in A. baumannii. IMPORTANCE Acinetobacter baumannii is rapidly emerging as a significant human pathogen, largely because of disinfectant and antibiotic resistance, causing lethal infection in fragile hosts. Despite the increasing prevalence of infections with multidrug-resistant A. baumannii strains, little is known regarding not only the molecular mechanisms that allow A. baumannii to resist environmental stresses (i.e., antibiotics and disinfectants) but also how these pathogens survive within an infected host to cause disease. We employed a large-scale genetic screen to identify genes required for A. baumannii to survive and grow in an insect disease model. While we identified many known virulence factors harbored by A. baumannii, we also discovered many novel genes that likely play key roles in A. baumannii survival of exposure to antibiotics and other stress-inducing chemicals. These results suggest that selection for increased resistance to antibiotics and environmental stress may inadvertently select for increased virulence in A. baumannii. C1 [Gebhardt, Michael J.; Jacobson, Rachael K.; Shuman, Howard A.] Univ Chicago, Dept Microbiol, Chicago, IL 60637 USA. [Gallagher, Larry A.] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA. [Usacheva, Elena A.; Peterson, Lance R.] NorthShore Univ HealthSystem, Dept Pathol Lab Med, Evanston, IL USA. [Zurawski, Daniel V.] Walter Reed Army Inst Res, Bacterial Dis Branch, Dept Wound Infect, Silver Spring, MD USA. RP Gebhardt, MJ (reprint author), Univ Chicago, Dept Microbiol, Chicago, IL 60637 USA. EM mgebhardt@uchicago.edu OI Zurawski, Daniel/0000-0002-7920-5601 FU National Institutes of Health (NIH) grant [T32 GM007183]; NIH [AI115203]; NorthShore/UCM collaborative research award; National Institute of Allergy and Infectious Diseases (NIAID) [U19AI107775]; MIDRP program; DMRDP program FX M.J.G. was supported by National Institutes of Health (NIH) grant T32 GM007183. H.A.S. was supported by the NIH (award AI115203) and by a NorthShore/UCM collaborative research award. L.A.G. was supported by grant U19AI107775 from the National Institute of Allergy and Infectious Diseases (NIAID). The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. D.V.Z. is supported by grants from the MIDRP and DMRDP programs and is grateful for continued support. The findings and opinions ex pressed herein belong to the authors and do not necessarily reflect the official views of the WRAIR, the U.S. Army, or the Department of Defense. NR 61 TC 5 Z9 5 U1 5 U2 13 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 2150-7511 J9 MBIO JI mBio PD NOV-DEC PY 2015 VL 6 IS 6 AR e01660-15 DI 10.1128/mBio.01660-15 PG 12 WC Microbiology SC Microbiology GA DA0YY UT WOS:000367524700035 PM 26556274 ER PT J AU Wong, GJ Osterberg, EC Hawley, RL Courville, ZR Ferris, DG Howley, JA AF Wong, G. J. Osterberg, E. C. Hawley, R. L. Courville, Z. R. Ferris, D. G. Howley, J. A. TI Coast-to-interior gradient in recent northwest Greenland precipitation trends (1952-2012) SO ENVIRONMENTAL RESEARCH LETTERS LA English DT Article DE Greenland; climate; precipitation; ice sheet; weather station; ice core; temperature ID SURFACE MASS-BALANCE; ICE-SHEET; ATLANTIC OSCILLATION; CLIMATE VARIABILITY; WEST GREENLAND; ACCUMULATION; CORES; TEMPERATURE; SENSITIVITY; ANTARCTICA AB The spatial and temporal variability of precipitation on the Greenland ice sheet is an essential component of surface mass balance, which has been declining in recent years with rising temperatures. We present an analysis of precipitation trends in northwest (NW) Greenland (1952-2012) using instrumental (coastal meteorological station) and proxy records (snow pits and ice cores) to characterize the precipitation gradient from the coast to the ice sheet interior. Snow-pit-derived precipitation near the coast (1950-2000) has increased (similar to 7% decade(-1), p < 0.01) whereas there is no significant change observed in interior snow pits. This trend holds for 1981-2012, where calculated precipitation changes decrease in magnitude with increasing distance from the coast: 13% decade(-1) (2.4 mm water equivalent (w.e.) decade(-2)) at coastal Thule air base (AB), 8.6% decade(-1) (4.7 mm w.e. decade(-2)) at the 2Barrel ice core site 150 km from Thule AB, -5.2% decade(-1) (1.7 mm w.e. decade(-2)) at Camp Century located 205 km from Thule AB, and 4.4% decade(-1) (1.0 mm w.e. decade(-2)) at B26 located 500 km from Thule AB. In general, annually averaged precipitation and annually and seasonally averaged mean air temperatures observed at Thule AB follow trends observed in composite coastal Greenland time series, with both notably indicating winter as the fastest warming season in recent periods (1981-2012). Trends (1961-2012) in seasonal precipitation differ, specifically with NW Greenland summer precipitation increasing (similar to 0.6 mm w.e. decade(-2)) in contrast with decreasing summer precipitation in the coastal composite time series (3.8 mm w.e. decade(-2)). Differences in precipitation trends between NW Greenland and coastal composite Greenland underscore the heterogeneity in climate influences affecting precipitation. In particular, recent (1981-2012) changes in NW Greenland annual precipitation are likely a response to a weakening North Atlantic oscillation. C1 [Wong, G. J.; Osterberg, E. C.; Hawley, R. L.; Courville, Z. R.; Ferris, D. G.; Howley, J. A.] Dartmouth Coll, Dept Earth Sci, Hanover, NH 03755 USA. [Courville, Z. R.] US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Wong, GJ (reprint author), Dartmouth Coll, Dept Earth Sci, Hanover, NH 03755 USA. EM gifford.j.wong.GR@dartmouth.edu FU National Science Foundation (NSF) [OPP-0909265, ARC-1107411]; NSF [DGE-0801490, DGE-0947790] FX This project was supported by the National Science Foundation (NSF) under grants OPP-0909265 and ARC-1107411, with additional support from NSF grants DGE-0801490 and DGE-0947790. Special thanks are given to Susanne Buchardt at the Centre for Ice and Climate (U. Copenhagen) for providing Camp Century and B26 delta18O and density data and the Danish Meteorological Institute for providing observed meteorological station data. NAO Index Data (PC-based) provided by the Climate Analysis section, NCAR, Boulder, USA, Hurrell (2003). We thank Mike Handley at the Climate Change Institute (U. Maine), Sarah Caughey and Lauren Culler (Dartmouth College) for help with snow pit and ice core analyses. We acknowledge Ben Kopec and Xiahong Feng for thoughtful discussions, and thank the editor and three anonymous reviewers whose comments and suggestions helped improve the manuscript. The authors have no conflict of interest. NR 52 TC 0 Z9 0 U1 4 U2 9 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 1748-9326 J9 ENVIRON RES LETT JI Environ. Res. Lett. PD NOV PY 2015 VL 10 IS 11 AR 114008 DI 10.1088/1748-9326/10/11/114008 PG 12 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA CZ6ZO UT WOS:000367249900012 ER PT J AU Morrill, JA Byrd, EFC AF Morrill, Jason A. Byrd, Edward F. C. TI Development of quantitative structure property relationships for predicting the melting point of energetic materials SO JOURNAL OF MOLECULAR GRAPHICS & MODELLING LA English DT Article DE Energetic materials; Melting point; QSPR; AM1 ID MECHANICAL MOLECULAR-MODELS; GAUSSIAN-BASIS SETS; ORGANIC-COMPOUNDS; ATOMS LI; APPROXIMATION; DESCRIPTORS; DESIGN; AM1; KR AB The accurate prediction of the melting temperature of organic compounds is a significant problem that has eluded researchers for many years. The most common approach used to develop predictive models entails the derivation of quantitative structure-property relationships (QSPRs), which are multivariate linear relationships between calculated quantities that are descriptors of molecular or electronic features and a property of interest. In this report the derivation of QSPRs to predict melting temperatures of energetic materials based on descriptors calculated using the AM1 semiempirical quantum mechanical method are described. In total, the melting points and experimental crystal structures of 148 energetic materials were analyzed. Principal components analysis was performed in order to assess the relative importance and roles of the descriptors in our QSPR models. Also described are the results of k means cluster analysis, performed in order to identify natural groupings within our study set of structures. The QSPR models resulting from these analyses gave training set R-2 values of 0.6085 (RMSE=+/- 15.7 degrees C) and 0.7468 (RMSE=+/- 13.2 degrees C). The test sets for these clusters had R-2 values of 0.9428 (RMSE = +/- 7.0 degrees C) and 0.8974 (RMSE = +/- 8.8 degrees C), respectively. These models are among the best melting point QSPRs yet published for energetic materials. (C) 2015 Elsevier Inc. All rights reserved. C1 [Morrill, Jason A.] William Jewell Coll, Dept Chem, Liberty, MO 64068 USA. [Byrd, Edward F. C.] US Army Res Labs, AMSRD ARL WM BD, Aberdeen Proving Ground, MD 21005 USA. RP Morrill, JA (reprint author), William Jewell Coll, Dept Chem, 500 Coll Hill, Liberty, MO 64068 USA. EM morrillj@william.jewell.edu FU U.S. Army Research Office Scientific Services Program [W911NF-11-D-0001] FX This work was performed under the auspices of the U.S. Army Research Office Scientific Services Program administered by Battelle Memorial Institute, Contract no. W911NF-11-D-0001. The authors would like to thank Thomas Klapotke and Jorg Stierstorfer for their assistance and the use of their crystal structure and melting point data. NR 35 TC 0 Z9 0 U1 2 U2 10 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1093-3263 EI 1873-4243 J9 J MOL GRAPH MODEL JI J. Mol. Graph. PD NOV PY 2015 VL 62 BP 190 EP 201 DI 10.1016/j.jmgm.2015.09.017 PG 12 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Computer Science, Interdisciplinary Applications; Crystallography; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Computer Science; Crystallography; Mathematical & Computational Biology GA CZ4ZN UT WOS:000367112000022 PM 26473455 ER PT J AU Fernando, HJS Pardyjak, ER Di Sabatino, S Chow, FK De Wekker, SFJ Hoch, SW Hacker, J Pace, JC Pratt, T Pu, Z Steenburgh, WJ Whiteman, CD Wang, Y Zajic, D Balsley, B Dimitrova, R Emmitt, GD Higgins, CW Hunt, JCR Knievel, JC Lawrence, D Liu, Y Nadeau, DF Kit, E Blomquist, BW Conry, P Coppersmith, RS Creegan, E Felton, M Grachev, A Gunawardena, N Hang, C Hocut, CM Huynh, G Jeglum, ME Jensen, D Kulandaivelu, V Lehner, M Leo, LS Liberzon, D Massey, JD McEnerney, K Pal, S Price, T Sghiatti, M Silver, Z Thompson, M Zhang, H Zsedrovits, T AF Fernando, H. J. S. Pardyjak, E. R. Di Sabatino, S. Chow, F. K. De Wekker, S. F. J. Hoch, S. W. Hacker, J. Pace, J. C. Pratt, T. Pu, Z. Steenburgh, W. J. Whiteman, C. D. Wang, Y. Zajic, D. Balsley, B. Dimitrova, R. Emmitt, G. D. Higgins, C. W. Hunt, J. C. R. Knievel, J. C. Lawrence, D. Liu, Y. Nadeau, D. F. Kit, E. Blomquist, B. W. Conry, P. Coppersmith, R. S. Creegan, E. Felton, M. Grachev, A. Gunawardena, N. Hang, C. Hocut, C. M. Huynh, G. Jeglum, M. E. Jensen, D. Kulandaivelu, V. Lehner, M. Leo, L. S. Liberzon, D. Massey, J. D. McEnerney, K. Pal, S. Price, T. Sghiatti, M. Silver, Z. Thompson, M. Zhang, H. Zsedrovits, T. TI THE MATERHORN Unraveling the Intricacies of Mountain Weather SO BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY LA English DT Article ID ATMOSPHERIC SURFACE-LAYER; PLANETARY BOUNDARY-LAYER; STRONGLY STRATIFIED FLOW; COMPLEX TERRAIN; EVENING TRANSITION; PACIFIC-NORTHWEST; DOPPLER LIDAR; HEAT-FLUX; PART I; MODEL C1 [Fernando, H. J. S.; Di Sabatino, S.; Pratt, T.; Dimitrova, R.; Hunt, J. C. R.; Kit, E.; Blomquist, B. W.; Conry, P.; Coppersmith, R. S.; Grachev, A.; Hocut, C. M.; Leo, L. S.; Liberzon, D.; McEnerney, K.; Silver, Z.; Thompson, M.; Zsedrovits, T.] Univ Notre Dame, Notre Dame, IN 46556 USA. [Pardyjak, E. R.; Hoch, S. W.; Pu, Z.; Steenburgh, W. J.; Whiteman, C. D.; Gunawardena, N.; Hang, C.; Jeglum, M. E.; Jensen, D.; Kulandaivelu, V.; Lehner, M.; Massey, J. D.; Price, T.; Zhang, H.] Univ Utah, Salt Lake City, UT USA. [Chow, F. K.] Univ Calif Berkeley, Berkeley, CA 94720 USA. [De Wekker, S. F. J.; Pal, S.; Sghiatti, M.] Univ Virginia, Charlottesville, VA USA. [Hacker, J.] Naval Postgrad Sch, Monterey, CA USA. [Hacker, J.; Knievel, J. C.; Liu, Y.] Natl Ctr Atmospher Res, Boulder, CO 80307 USA. [Pace, J. C.; Zajic, D.] US Army Dugway Proving Ground, Salt Lake City, UT USA. [Creegan, E.; Felton, M.; Huynh, G.] US Army Res Lab, Adelphi, MD USA. [Balsley, B.; Lawrence, D.; Blomquist, B. W.; Grachev, A.] Univ Colorado, Boulder, CO 80309 USA. [Emmitt, G. D.] Simpson Weather Associates, Charlottesville, VA USA. [Higgins, C. W.] Oregon State Univ, Corvallis, OR 97331 USA. [Nadeau, D. F.] Ecole Polytech, Montreal, PQ H3C 3A7, Canada. [Kit, E.] Tel Aviv Univ, IL-69978 Tel Aviv, Israel. [Blomquist, B. W.; Grachev, A.] Natl Ocean & Atmospher Adm, Silver Spring, MD USA. RP Fernando, HJS (reprint author), Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, Environm Fluid Dynam Labs, 156 Fitzpatrick Hall, Notre Dame, IN 46556 USA. EM hfernand@nd.edu RI Zsedrovits, Tamas/D-1362-2016; Leo, Laura/J-9529-2013; OI Zsedrovits, Tamas/0000-0003-0768-1171; Leo, Laura/0000-0003-4103-6862; GRACHEV, ANDREY/0000-0002-7143-0820 FU Office of Naval Research (MURI) Award [N00014-11-1-0709]; Army Research Office; Air Force Weather Agency; Research Office of University of Notre Dame; Research Office of University of Utah; Wayne and Diana Murdy Family Endowment at Notre Dame FX The MATERHORN Program was funded by the Office of Naval Research (MURI) Award N00014-11-1-0709 (Program Officers: Drs. Ronald Ferek and Daniel Eleuterio), with additional funding from the Army Research Office (Program Officers: Gordon Videen and Walter Bach), Air Force Weather Agency, Research Offices of University of Notre Dame and University of Utah, and Wayne and Diana Murdy Family Endowment at Notre Dame. MATERHORN-M gratefully acknowledges the DART team at NCAR, the U.S. Army Test and Evaluation Command, DoD High-Performance Computing Modernization Program (HPCMP), High Performance Computing at UU, Center for Research Computing (CRC), and Engineering and Science Computing (ESC) at UND. The GIS rendition of Fig. 4 was skillfully prepared by Dott. Ing. Roberto Perrone, Territorial Planning Department of Province of Lecce, Italy. Without the invaluable support of Chris Fairall (ESRL/PSD, NOAA), Vanda Grubisic, and Steven Oncley (EOL, NCAR), James Doyle (Naval Research Laboratory), many DPG and U.S. government personnel, domestic, and international visitors, as well as a host of technical staff, the program could not have been a reality. Four referees provided invaluable comments that improved the paper substantially. NR 99 TC 25 Z9 25 U1 6 U2 26 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0003-0007 EI 1520-0477 J9 B AM METEOROL SOC JI Bull. Amer. Meteorol. Soc. PD NOV PY 2015 VL 96 IS 11 DI 10.1175/BAMS-D-13-00131.1 PG 24 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA CZ3GQ UT WOS:000366992800001 ER PT J AU Churaman, WA Morris, CJ Ramachandran, R Bergbreiter, S AF Churaman, Wayne A. Morris, Christopher J. Ramachandran, Raghav Bergbreiter, Sarah TI The effect of porosity on energetic porous silicon solid propellant micro-propulsion SO JOURNAL OF MICROMECHANICS AND MICROENGINEERING LA English DT Article DE microthruster; porous silicon; impulse; thrust ID VAPORIZING LIQUID MICROTHRUSTER AB Energetic porous silicon is investigated as an actuator for micro-propulsion based on thrust and impulse measurements for a variety of porous silicon porosity conditions. Porosity of 2 mm diameter, porous silicon microthruster devices was varied by changing the concentration of hydrofluoric acid and ethanol in an etch solution, by changing porous silicon etch depth, and by changing the resistivity of silicon wafers used for the etch process. The porosity varied from 30% to 75% for these experiments. The highest mean thrust and impulse values measured with a calibrated Kistler 9215 force sensor were 674 mN and 271 mu N s, respectively, with a 73% porosity, 2 mm diameter porous silicon device etched in a 3 : 1 etch solution on a 3.6 Omega cm wafer to a target etch depth of 30 mu m. As a result of changing porosity, a 23x increase in thrust performance and a 36x increase in impulse performance was demonstrated. Impulse values were also validated using a pendulum experiment in which the porous silicon microthruster was unconstrained, but several non-linearities in the pendulum experimental setup resulted in less consistent data than when measured by the force sensor for microthrusters at this size scale. These thrust and impulse results complement previous work in determining the effect of porosity on other porous silicon reaction metrics such as flame speed. C1 [Churaman, Wayne A.; Morris, Christopher J.] US Army Res Lab, Adelphi, MD 20783 USA. [Churaman, Wayne A.; Bergbreiter, Sarah] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. [Ramachandran, Raghav] Purdue Univ, Dept Mech Engn, W Lafayette, IN 47907 USA. RP Churaman, WA (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM wayne.a.churaman.civ@mail.mil NR 29 TC 0 Z9 0 U1 6 U2 7 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0960-1317 EI 1361-6439 J9 J MICROMECH MICROENG JI J. Micromech. Microeng. PD NOV PY 2015 VL 25 IS 11 AR 115022 DI 10.1088/0960-1317/25/11/115022 PG 11 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Instruments & Instrumentation; Physics, Applied SC Engineering; Science & Technology - Other Topics; Instruments & Instrumentation; Physics GA CZ1JM UT WOS:000366862100025 ER PT J AU Fu, C Arguello, H Sadler, BM Arce, GR AF Fu, Chen Arguello, Henry Sadler, Brian M. Arce, Gonzalo R. TI Compressive spectral polarization imaging by a pixelized polarizer and colored patterned detector SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION LA English DT Article ID FOCAL-PLANE POLARIMETERS; MICROPOLARIZER ARRAY; FILTER ARRAYS; BLUE-NOISE; DIVISION; DESIGN; CALIBRATION; SENSOR AB A compressive spectral and polarization imager based on a pixelized polarizer and colored patterned detector is presented. The proposed imager captures several dispersed compressive projections with spectral and polarization coding. Stokes parameter images at several wavelengths are reconstructed directly from 2D projections. Employing a pixelized polarizer and colored patterned detector enables compressive sensing over spatial, spectral, and polarization domains, reducing the total number of measurements. Compressive sensing codes are specially designed to enhance the peak signal-to-noise ratio in the reconstructed images. Experiments validate the architecture and reconstruction algorithms. (C) 2015 Optical Society of America C1 [Fu, Chen; Arce, Gonzalo R.] Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA. [Arguello, Henry] Univ Ind Santander, Bucaramanga, Colombia. [Sadler, Brian M.] US Army Res Lab, Adelphi, MD 20783 USA. RP Fu, C (reprint author), Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA. EM fuchen@udel.edu FU Army Research Office (ARO) [W911NF-12-1-0380]; BW Tek, Inc.; Defense University Research Instrumentation Program (DURIP) [W911NF-14-1-0522] FX Army Research Office (ARO) (W911NF-12-1-0380); B&W Tek, Inc.; Defense University Research Instrumentation Program (DURIP) (W911NF-14-1-0522). NR 34 TC 2 Z9 2 U1 1 U2 7 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1084-7529 EI 1520-8532 J9 J OPT SOC AM A JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis. PD NOV 1 PY 2015 VL 32 IS 11 BP 2178 EP 2188 DI 10.1364/JOSAA.32.002178 PG 11 WC Optics SC Optics GA CZ6HK UT WOS:000367201600029 PM 26560932 ER PT J AU Torrieri, D Talarico, S Valenti, MC AF Torrieri, Don Talarico, Salvatore Valenti, Matthew C. TI Performance Comparisons of Geographic Routing Protocols in Mobile Ad Hoc Networks SO IEEE TRANSACTIONS ON COMMUNICATIONS LA English DT Article DE Geographic routing; ad hoc network; area spectral efficiency; path reliability ID ACCESS TRANSPORT CAPACITY; WIRELESS NETWORKS; INTERFERENCE AB Geographic routing protocols greatly reduce the requirements of topology storage and provide flexibility in the accommodation of the dynamic behavior of mobile ad hoc networks. This paper presents performance evaluations and comparisons of two geographic routing protocols and the popular AODV protocol. The tradeoffs among the average path reliabilities, average conditional delays, average conditional numbers of hops, and area spectral efficiencies and the effects of various parameters are illustrated for finite ad hoc networks with randomly placed mobiles. This paper uses a dual method of closed-form analysis and simple simulation that is applicable to most routing protocols and provides a much more realistic performance evaluation than has previously been possible. Some features included in the new analysis are shadowing, exclusion and guard zones, distance-dependent fading, and interference correlation. C1 [Torrieri, Don] US Army Res Lab, Adelphi, MD 20783 USA. [Talarico, Salvatore; Valenti, Matthew C.] W Virginia Univ, Lane Dept Comp Sci & Elect Engn, Morgantown, WV 26506 USA. RP Torrieri, D (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM don.j.torrieri.civ@mail.mil; salvatore.talarico81@gmail.com; valenti@ieee.org OI Valenti, Matthew/0000-0001-6089-0509 NR 22 TC 2 Z9 2 U1 0 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0090-6778 EI 1558-0857 J9 IEEE T COMMUN JI IEEE Trans. Commun. PD NOV PY 2015 VL 63 IS 11 BP 4276 EP 4286 DI 10.1109/TCOMM.2015.2477337 PG 11 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA CY6GK UT WOS:000366506500030 ER PT J AU Sawka, MN Cheuvront, SN Kenefick, RW AF Sawka, Michael N. Cheuvront, Samuel N. Kenefick, Robert W. TI Hypohydration and Human Performance: Impact of Environment and Physiological Mechanisms SO SPORTS MEDICINE LA English DT Review ID EXERCISE PERFORMANCE; HEAT-STRESS; SKIN TEMPERATURE; DEHYDRATION ASSESSMENT; AEROBIC PERFORMANCE; PROLONGED EXERCISE; FLUID REPLACEMENT; HEALTHY HUMANS; BLOOD-FLOW; SWEAT RATE AB Body water losses of >2 % of body mass are defined as hypohydration and can occur from sweat loss and/or diuresis from both cold and altitude exposure. Hypohydration elicits intracellular and extracellular water loss proportionate to water and solute deficits. Iso-osmotic hypovolemia (from cold and high-altitude exposure) results in greater plasma loss for a given water deficit than hypertonic hypovolemia from sweat loss. Hypohydration does not impair submaximal intensity aerobic performance in cold-cool environments, sometimes impairs aerobic performance in temperate environments, and usually impairs aerobic performance in warm-hot environments. Hypohydration begins to impair aerobic performance when skin temperatures exceed 27 degrees C, and with each additional 1 degrees C elevation in skin temperature there is a further 1.5 % impairment. Hypohydration has an additive effect on impairing aerobic performance in warm-hot high-altitude environments. A commonality of absolute hypovolemia (from plasma volume loss) combined with relative hypovolemia (from tissue vasodilation) is present when aerobic performance is impaired. The decrement in aerobic exercise performance due to hypohydration is likely due to multiple physiological mechanisms, including cardiovascular strain acting as the 'lynchpin', elevated tissue temperatures, and metabolic changes which are all integrated through the CNS to reduce motor drive to skeletal muscles. C1 [Sawka, Michael N.] Georgia Inst Technol, Sch Appl Physiol, Atlanta, GA 30332 USA. [Cheuvront, Samuel N.; Kenefick, Robert W.] US Army, Thermal & Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA. RP Sawka, MN (reprint author), Georgia Inst Technol, Sch Appl Physiol, 555 14th St, Atlanta, GA 30332 USA. EM michael.sawka@ap.gatech.edu FU Gatorade Sports Science Institute (GSSI) FX This article was published in a supplement supported by the Gatorade Sports Science Institute (GSSI). The supplement was guest edited by Lawrence L. Spriet who attended a meeting of the GSSI expert panel (XP) in March 2014 and received honoraria from GSSI for his participation in the meeting. He received no honoraria for guest editing the supplement. Dr. Spriet selected peer reviewers for each paper and managed the process. Michael Sawka, PhD also attended the GSSI XP meeting in March 2014 and received honoraria from the GSSI, a division of PepsiCo, Inc., for his meeting participation and the writing of this manuscript. The views expressed in this manuscript are those of the author and do not necessarily reflect the position or policy of PepsiCo, Inc. The opinions or assertions contained herein are the private views of the authors and should not be construed as official or reflecting the views of the Army or the Department of Defense. Approved for public release: distribution unlimited. NR 76 TC 4 Z9 4 U1 10 U2 28 PU ADIS INT LTD PI NORTHCOTE PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND SN 0112-1642 EI 1179-2035 J9 SPORTS MED JI Sports Med. PD NOV PY 2015 VL 45 SU 1 BP S51 EP S60 DI 10.1007/s40279-015-0395-7 PG 10 WC Sport Sciences SC Sport Sciences GA CZ0XN UT WOS:000366829800006 PM 26553489 ER PT J AU Olcese, SP Chiricosta, FM Farnsworth, TG Kim, YW McMann, LP AF Olcese, Seth P. Chiricosta, Francis M. Farnsworth, Thoran G. Kim, Young W. McMann, Leah P. TI Testicular Cystic Walthard Cell Nest in a 7-Month-Old SO UROLOGY LA English DT Article ID TESTIS; TUMORS; LESIONS AB Walthard cell nests have previously been reported arising from paratesticular structures; however, this is the first reported case of an intratesticular Walthard cell nest. We report our experience with this lesion which is interesting not only because of its extreme rarity but also because of the proposed histogenesis of such lesions. Published by Elsevier Inc. C1 Tripler Army Med Ctr, Dept Surg, Urol Serv, Honolulu, HI 96859 USA. Tripler Army Med Ctr, Dept Pathol, Honolulu, HI 96859 USA. Tripler Army Med Ctr, Dept Radiol, Honolulu, HI 96859 USA. RP Olcese, SP (reprint author), Tripler Army Med Ctr, Dept Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM Seth.P.Olcese.mil@us.army.mil NR 10 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-4295 EI 1527-9995 J9 UROLOGY JI Urology PD NOV PY 2015 VL 86 IS 5 BP 998 EP 1000 DI 10.1016/j.urology.2015.07.033 PG 3 WC Urology & Nephrology SC Urology & Nephrology GA CY5RZ UT WOS:000366466400040 PM 26278822 ER PT J AU Dunn, JC Belmont, PJ Lanzi, J Martin, K Bader, J Owens, B Waterman, BR AF Dunn, John C. Belmont, Philip J. Lanzi, Joseph Martin, Kevin Bader, Julia Owens, Brett Waterman, Brian R. TI Arthroscopic Shoulder Surgical Simulation Training Curriculum: Transfer Reliability and Maintenance of Skill Over Time SO JOURNAL OF SURGICAL EDUCATION LA English DT Article DE simulation; surgical training; transfer validity; shoulder; arthroscopy ID SURGERY; ARTHROPLASTY; RESIDENTS; MORTALITY; TRIAL AB BACKGROUND: Surgical education is evolving as work hour constraints limit the exposure of residents to the operating room. Potential consequences may include erosion of resident education and decreased quality of patient care. Surgical simulation training has become a focus of study in an effort to counter these challenges. Previous studies have validated the use of arthroscopic surgical simulation programs both in vitro and in vivo. However, no study has examined if the gains made by residents after a simulation program are retained after a period away from training. METHODS: In all, 17 orthopedic surgery residents were randomized into simulation or standard practice groups. All subjects were oriented to the arthroscopic simulator, a 14-point anatomic checklist, and Arthroscopic Surgery Skill Evaluation Tool (ASSET). The experimental group received 1 hour of simulation training whereas the control group had no additional training. All subjects performed a recorded, diagnostic arthroscopy intraoperatively. These videos were scored by 2 blinded, fellowship-trained orthopedic surgeons and outcome measures were compared within and between the groups. After 1 year in which neither group had exposure to surgical simulation training, all residents were retested intraoperatively and scored in the exact same fashion. Individual surgical case logs were reviewed and surgical case volume was documented. RESULTS: There was no difference between the 2 groups after initial simulation testing and there was no correlation between case volume and initial scores. After training, the simulation group improved as compared with baseline in mean ASSET (p = 0.023) and mean time to completion (p = 0.01). After 1 year, there was no difference between the groups in any outcome measurements. CONCLUSION: Although individual technical skills can be cultivated with surgical simulation training, these advancements can be lost without continued education. It is imperative that residency programs implement a simulation curriculum and continue to train throughout the academic year. (Published by Elsevier Inc on behalf of the Association of Program Directors in Surgery) C1 [Dunn, John C.; Belmont, Philip J.; Lanzi, Joseph; Bader, Julia; Waterman, Brian R.] William Beaumont Army Med Ctr, Dept Orthopaed Surg & Rehabil, Ft Bliss, TX USA. [Martin, Kevin] Evans Army Community Hosp, Dept Orthopaed Surg, Ft Carson, CO USA. [Owens, Brett] Keller Army Community Hosp, Dept Orthopaed Surg, West Point, NY USA. RP Waterman, BR (reprint author), William Beaumont Army Med Ctr, Dept Orthopaed Surg & Rehabil, 5005 N Piedras St, El Paso, TX 79920 USA. EM dunnjohnc@gmail.com NR 32 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1931-7204 EI 1878-7452 J9 J SURG EDUC JI J. Surg. Educ. PD NOV-DEC PY 2015 VL 72 IS 6 BP 1118 EP 1123 DI 10.1016/j.jsurg.2015.06.021 PG 6 WC Education, Scientific Disciplines; Surgery SC Education & Educational Research; Surgery GA CY2LM UT WOS:000366240200009 PM 26298520 ER PT J AU Sarney, WL Svensson, SP AF Sarney, Wendy L. Svensson, Stefan P. TI Flux dependent Sb-incorporation during molecular beam epitaxy of InAsSb SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article ID STRAINED-LAYER SUPERLATTICES; INAS1-XSBX; PHOTOLUMINESCENCE; ALLOYS; GROWTH AB A strong dependence of the InAsSb composition on the group III flux during molecular beam epitaxy growth has been observed and quantified. Analogous to group III alloying, the Sb concentration is expressed as the ratio of the Sb to the sum of the group V fluxes, modified by an empirical interaction parameter that is strongly dependent on the In flux. A well-behaved quadratic polynomial characterizes this parameter. By extrapolating the growth rate to zero, important information about the Sb-As exchange reaction of a static surface can be extracted and the required Sb/As flux ratio to maintain stoichiometry is predicted. C1 [Sarney, Wendy L.; Svensson, Stefan P.] US Army Res Lab, Adelphi, MD 20783 USA. RP Sarney, WL (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM Wendy.L.Sarney.civ@mail.mil; Stefan.P.Svensson.civ@mail.mil NR 12 TC 2 Z9 2 U1 2 U2 6 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD NOV PY 2015 VL 33 IS 6 AR 060604 DI 10.1116/1.4935892 PG 3 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA CX9WE UT WOS:000366055600051 ER PT J AU Ahmed, HM Windham, AD Al-Ejji, MM Al-Qahtani, NH Hassan, MK Mauritz, KA Buchanan, RK Buchanan, JP AF Ahmed, Hanaa M. Windham, Amber D. Al-Ejji, Maryam M. Al-Qahtani, Noora H. Hassan, Mohammad K. Mauritz, Kenneth A. Buchanan, Randy K. Buchanan, J. Paige TI Preparation and Preliminary Dielectric Characterization of Structured C-60- Thiol-Ene Polymer Nanocomposites Assembled Using the Thiol-Ene Click Reaction SO MATERIALS LA English DT Article DE dielectric properties; fullerenol; thiol-ene; nanocomposites ID FULLERENE; COPOLYMERS; FILMS AB Fullerene-containing materials have the ability to store and release electrical energy. Therefore, fullerenes may ultimately find use in high-voltage equipment devices or as super capacitors for high electric energy storage due to this ease of manipulating their excellent dielectric properties and their high volume resistivity. A series of structured fullerene (C-60) polymer nanocomposites were assembled using the thiol-ene click reaction, between alkyl thiols and allyl functionalized C-60 derivatives. The resulting high-density C-60-urethane-thiol-ene (C-60-Thiol-Ene) networks possessed excellent mechanical properties. These novel networks were characterized using standard techniques, including infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), and thermal gravimetric analysis (TGA). The dielectric spectra for the prepared samples were determined over a broad frequency range at room temperature using a broadband dielectric spectrometer and a semiconductor characterization system. The changes in thermo-mechanical and electrical properties of these novel fullerene-thiol-ene composite films were measured as a function of the C-60 content, and samples characterized by high dielectric permittivity and low dielectric loss were produced. In this process, variations in chemical composition of the networks were correlated to performance characteristics. C1 [Ahmed, Hanaa M.; Windham, Amber D.; Buchanan, J. Paige] Univ So Mississippi, Dept Chem & Biochem, Hattiesburg, MS 39406 USA. [Al-Ejji, Maryam M.; Al-Qahtani, Noora H.; Hassan, Mohammad K.] Qatar Univ, Ctr Adv Mat, Doha, Qatar. [Mauritz, Kenneth A.] Univ So Mississippi, Sch Polymers & High Performance Mat, Hattiesburg, MS 39406 USA. [Buchanan, Randy K.] US Army Engineer Res & Dev Ctr, Informat Technol Lab, Inst Syst Engn Res, Vicksburg, MS 39180 USA. [Ahmed, Hanaa M.] Benha Univ, Fac Engn, Banha 13512, Egypt. RP Buchanan, JP (reprint author), Univ So Mississippi, Dept Chem & Biochem, 118 Coll Dr, Hattiesburg, MS 39406 USA. EM Hanaa.ahmed76@gmail.com; amber.gresham@eagles.usm.edu; maryam.alejji@qu.edu.qa; noora.alqahtani@qu.edu.qa; mohamed.hassan@qu.edu.qa; kenneth.mauritz@usm.edu; Randy.K.Buchanan@erdc.dren.mil; paige.buchanan@usm.edu FU National Science Foundation Early Career Development (CAREER) Program [CHE-0847481]; Center for Advanced Materials' Start-Up grant FX J. Paige Buchanan gratefully acknowledges funding for this research provided through the National Science Foundation Early Career Development (CAREER) Program under award number CHE-0847481. Mohammad K. Hassan would like to acknowledge the Qatar University's financial support through the Center for Advanced Materials' Start-Up grant. NR 22 TC 4 Z9 4 U1 3 U2 13 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1996-1944 J9 MATERIALS JI Materials PD NOV PY 2015 VL 8 IS 11 BP 7795 EP 7804 DI 10.3390/ma8115424 PG 10 WC Materials Science, Multidisciplinary SC Materials Science GA CX8AQ UT WOS:000365924500047 ER PT J AU Varghese, R Narayanan, S Leber, D Viswan, R Mu, MK Sanghadasa, M Priya, S AF Varghese, Ronnie Narayanan, Shree Leber, Donald Viswan, Ravindranath Mu, Mingkai Sanghadasa, Mohan Priya, Shashank TI Magnetoelectric macro fiber composite SO SENSORS AND ACTUATORS A-PHYSICAL LA English DT Article DE Macro fiber composite; Low temperature bonding; Magnetoelectric composite; Energy harvesting; Magnetic sensor ID MULTIFERROIC LAMINATED COMPOSITES; LEAD-ZIRCONATE-TITANATE AB This paper describes the fabrication and performance results of a magnetoelectric macro fiber composite (ME MFC). The magnetoelectric composite was fabricated by bonding a magnetostrictive layer to a piezoelectric layer using a novel approach of low temperature transient liquid phase (LTTLP) bonding. The composite was diced into 150 micron wide fibers and bonded to a custom designed copper flexible circuit using a spin coated low viscosity room temperature curing epoxy. ME MFC's with varying ferrite thicknesses of 0.6mm and 0.5 mm were fabricated and characterized for energy harvesting. The composite with 0.6mm ferrite thickness achieved an open circuit voltage of 101 mV (ME voltage coefficient of 6740 mV/cmOe) and peak power of 3.1 nW across 356 k Omega matching load at 264 Hz. (C) 2015 Elsevier B.V. All rights reserved. C1 [Varghese, Ronnie; Priya, Shashank] Virginia Tech, Bioinspired Mat & Devices Lab BMDL, Ctr Energy Harvesting Mat & Syst CEHMS, Blacksburg, VA 24061 USA. [Viswan, Ravindranath] Virginia Tech, Mat Sci & Engn Dept, Blacksburg, VA 24061 USA. [Narayanan, Shree; Leber, Donald; Mu, Mingkai] Virginia Tech, Elect & Comp Engn Dept, Blacksburg, VA 24061 USA. [Sanghadasa, Mohan] US Army Res Dev & Engn Command, Weap Sci Directorate, Redstone Arsenal, AL 35898 USA. RP Varghese, R (reprint author), Virginia Tech, Bioinspired Mat & Devices Lab BMDL, Ctr Energy Harvesting Mat & Syst CEHMS, Blacksburg, VA 24061 USA. EM ronniev@vt.edu FU Air Force Office of Scientific Research (AFOSR); Office of Basic Energy Science, Department of Energy FX The authors gratefully acknowledge the financial support from Air Force Office of Scientific Research (AFOSR) through Young Investigator Program and Office of Basic Energy Science, Department of Energy (S.P.). We are also greatly indebted to Justin Farmer CEHMS Laboratory manager for help with the experimental setup. We also would like to thank Bret Halpern of Jet Process Corporation, North Haven, CT for the solder deposition and T.J. Belton and Travis Belton of Moog Components Group Galax Operations, Galax, VA for flexible circuit fabrication. NR 22 TC 0 Z9 0 U1 8 U2 25 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0924-4247 J9 SENSOR ACTUAT A-PHYS JI Sens. Actuator A-Phys. PD NOV 1 PY 2015 VL 235 BP 64 EP 70 DI 10.1016/j.sna.2015.09.033 PG 7 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA CY2JY UT WOS:000366236000007 ER PT J AU Hew-Butler, T Rosner, MH Fowkes-Godek, S Dugas, JP Hoffman, MD Lewis, DP Maughan, RJ Miller, KC Montain, SJ Rehrer, NJ Roberts, WO Rogers, IR Siegel, AJ Stuempfle, KJ Winger, JM Verbalis, JG AF Hew-Butler, Tamara Rosner, Mitchell H. Fowkes-Godek, Sandra Dugas, Jonathan P. Hoffman, Martin D. Lewis, Douglas P. Maughan, Ronald J. Miller, Kevin C. Montain, Scott J. Rehrer, Nancy J. Roberts, William O. Rogers, Ian R. Siegel, Arthur J. Stuempfle, Kristin J. Winger, James M. Verbalis, Joseph G. TI Statement of the 3rd International Exercise-Associated Hyponatremia Consensus Development Conference, Carlsbad, California, 2015 SO BRITISH JOURNAL OF SPORTS MEDICINE LA English DT Article ID SERUM SODIUM CONCENTRATION; INTRAVENOUS HYPERTONIC SALINE; COLLAPSED ULTRAMARATHON RUNNERS; CANYON-NATIONAL-PARK; TOTAL-BODY WATER; CYSTIC-FIBROSIS; SYMPTOMATIC HYPONATREMIA; IRONMAN TRIATHLON; MARATHON RUNNERS; ENDURANCE EXERCISE C1 [Hew-Butler, Tamara] Oakland Univ, Exercise Sci Program, Rochester, MI 48309 USA. [Rosner, Mitchell H.] Univ Virginia Hlth Syst, Div Nephrol, Charlottesville, VA USA. [Fowkes-Godek, Sandra] W Chester Univ, Dept Sports Med, W Chester, PA 19380 USA. [Dugas, Jonathan P.] Vital Grp, Chicago, IL USA. [Hoffman, Martin D.] VA Northern Calif Hlth Care Syst, Dept Phys Med & Rehabil, Sacramento, CA USA. [Hoffman, Martin D.] Univ Calif Davis, Sacramento, CA 95817 USA. [Lewis, Douglas P.] Via Christi Hosp Wichita Inc, Family Med Residency Program, Wichita, KS USA. [Maughan, Ronald J.] Univ Loughborough, Dept Sport & Exercise Nutr, Loughborough, Leics, England. [Miller, Kevin C.] Cent Michigan Univ, Athlet Training Program, Mt Pleasant, MI 48859 USA. [Montain, Scott J.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA USA. [Rehrer, Nancy J.] Univ Otago, Sch Phys Educ Sport & Exercise Sci, Dunedin, New Zealand. [Roberts, William O.] Univ Minnesota, Dept Family Med & Community Hlth, Minneapolis, MN USA. [Rogers, Ian R.] St John God Murdoch Hosp, Dept Emergency Med, Perth, WA, Australia. [Rogers, Ian R.] Univ Notre Dame, Perth, WA, Australia. [Siegel, Arthur J.] Harvard Univ, Sch Med, Dept Internal Med, Boston, MA USA. [Stuempfle, Kristin J.] Gettysburg Coll, Dept Hlth Sci, Gettysburg, PA 17325 USA. [Winger, James M.] Loyola Univ, Stritch Sch Med, Dept Family Med, Chicago, IL 60611 USA. [Verbalis, Joseph G.] Georgetown Univ, Med Ctr, Dept Endocrinol & Metab, Washington, DC 20007 USA. RP Hew-Butler, T (reprint author), Oakland Univ, Sch Hlth Sci, Rochester, MI 48309 USA. EM hew@oakland.edu RI maughan, ron/G-5370-2016; OI maughan, ron/0000-0002-7642-354X; Hoffman, Martin/0000-0001-8819-5989; Roberts, William O/0000-0003-4517-4330 FU food and beverage industry FX RJM has received research funding and consulting fees from the food and beverage industry. He is currently Chair of the Science Advisory Board of the European Hydration Institute. NR 189 TC 4 Z9 4 U1 2 U2 4 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0306-3674 EI 1473-0480 J9 BRIT J SPORT MED JI Br. J. Sports Med. PD NOV PY 2015 VL 49 IS 22 BP 1432 EP 1446 DI 10.1136/bjsports-2015-095004 PG 15 WC Sport Sciences SC Sport Sciences GA CX6FP UT WOS:000365796900009 PM 26227507 ER PT J AU Zhong, XL Pandey, R Karna, SP AF Zhong, Xiaoliang Pandey, Ravindra Karna, Shashi P. TI First principles study of bilayer graphene formed by zigzag nanoribbons SO IET CIRCUITS DEVICES & SYSTEMS LA English DT Article DE graphene; nanoribbons; density functional theory; bilayer graphene; zigzag graphene nanoribbon; GNR; density function theory; AB- bilayer; AB- bilayer; geometry optimisation process; energy surface; AB-stacking; electronic structure calculation ID STATE; TRANSPORT; EDGE AB The authors investigate stability of several bilayer configurations formed by 6- and 12-zigzag graphene nanoribbons (GNR) in the framework of density function theory. Electronic structure calculations find the AB- bilayer to be energetically preferred, and the AB- bilayer is found to converge to the AB- bilayer in the geometry optimisation process. Besides the AB- bilayer, the authors find other stable bilayer configurations as local minima on the energy surface obtained by displacing the top layer relative to the bottom layer of GNR. These configurations are associated with the AB-stacking and predicted to be magnetic in nature, thus making the bilayer GNRs to be promising candidates for device applications at nanoscale. C1 [Zhong, Xiaoliang; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. [Karna, Shashi P.] US Army, Res Lab, Weap & Mat Res Directorate, ATTN RDL WM, Aberdeen Proving Ground, MD 21005 USA. RP Pandey, R (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. EM pandey@mtu.edu RI Zhong, Xiaoliang/B-2220-2012 NR 22 TC 0 Z9 0 U1 2 U2 6 PU INST ENGINEERING TECHNOLOGY-IET PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND SN 1751-858X EI 1751-8598 J9 IET CIRC DEVICE SYST JI IET Circ. Devices Syst. PD NOV PY 2015 VL 9 IS 6 SI SI BP 386 EP 391 DI 10.1049/iet-cds.2014.0362 PG 6 WC Engineering, Electrical & Electronic SC Engineering GA CX4CS UT WOS:000365646500002 ER PT J AU Willson, TJ Swiss, T Barrera, JE AF Willson, Thomas J. Swiss, Tyler Barrera, Jose E. TI Quantifying Changes in Nasal Tip Support SO JAMA FACIAL PLASTIC SURGERY LA English DT Article ID TRIPOD THEORY; MODEL; RHINOPLASTY; CARTILAGE AB IMPORTANCE Imparting surgical change to the nasal tip remains one the most challenging aspects of rhinoplasty. The surgeon must assess the tip preoperatively and execute the necessary maneuvers to impart the desired change. OBJECTIVE To assess nasal tip resistance to compression in a cadaveric model before and after specific rhinoplasty maneuvers using a novel method. DESIGN, SETTING, AND MATERIALS Open rhinoplasty maneuvers were performed at an academic tertiary care center on 6 fresh-thawed cadaver heads. Assessment of tip support was performed with a motorized, computer-controlled test stand equipped with a digital load cell. Tip support was assessed by compression to a depth of 2.5 mm from contact both preoperatively and after each surgical maneuver. All force data were recorded in pound-force and converted to newtons (N) following analysis. MAIN OUTCOMES AND MEASURES Nasal tip support, measured as resistance to compression, before and after various rhinoplasty maneuvers. RESULTS Following the elevation of the skin-soft-tissue envelope with septoplasty, resistance to compression (1.82 N) was not significantly different from the preoperative assessment (1.60 N for all specimens). Tip support following placement of a caudal extension graft was significantly different from all other conditions (3.16 N; P < .01), showing support increased by more than 66% from preoperative assessment. Placement of columellar strut (1.28 N) did not show significant increase in tip support. Tip support was decreased slightly after placement of intradomal sutures, which was significant (1.22 N; P < .01). CONCLUSIONS AND RELEVANCE This study demonstrates the use of materials testing equipment to assess and quantify change in tip support after several rhinoplasty maneuvers. Minor supporting maneuvers that rely on healing and scar do not significantly alter tip support in a cadaveric model. Caudal extension graft is an important maneuver imparting significant effect on nasal tip support. C1 [Willson, Thomas J.] San Antonio Mil Med Ctr, Dept Otolaryngol Head & Neck Surg, San Antonio, TX 78234 USA. [Swiss, Tyler] Tripler Army Med Ctr, Dept Hlth Educ & Training, Honolulu, HI 96859 USA. [Barrera, Jose E.] Texas Facial Plast Surg & ENT, San Antonio, TX USA. [Barrera, Jose E.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Barrera, Jose E.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. RP Willson, TJ (reprint author), San Antonio Mil Med Ctr, Dept Otolaryngol Head & Neck Surg, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA. EM S10twillson@gmail.com FU San Antonio Military Medical Center (SAMMC) Department of Clinical Investigations FX A grant from the San Antonio Military Medical Center (SAMMC) Department of Clinical Investigations was used to purchase specimens and equipment for this research. NR 15 TC 2 Z9 2 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6076 EI 2168-6092 J9 JAMA FACIAL PLAST SU JI JAMA Facial Plast. Surg. PD NOV-DEC PY 2015 VL 17 IS 6 BP 428 EP 432 DI 10.1001/jamafacial.2015.1035 PG 5 WC Surgery SC Surgery GA CX1PX UT WOS:000365469200009 PM 26379117 ER PT J AU Manak, MM Njoku, OS Shutt, A Malia, J Jagodzinski, LL Milazzo, M Suleiman, A Ogundeji, AA Nelson, R Ayemoba, OR O'Connell, RJ Singer, DE Michael, NL Peel, SA AF Manak, Mark M. Njoku, Ogbonnaya S. Shutt, Ashley Malia, Jennifer Jagodzinski, Linda L. Milazzo, Mark Suleiman, Aminu Ogundeji, Amos A. Nelson, Robert Ayemoba, Ojor R. O'Connell, Robert J. Singer, Darrell E. Michael, Nelson L. Peel, Sheila A. TI Evaluation of Performance of Two Rapid Tests for Detection of HIV-1 and-2 in High- and Low-Prevalence Populations in Nigeria SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID DRUG-RESISTANCE; ANTIRETROVIRAL THERAPY; RISK BEHAVIORS; INFECTION; UGANDA; INDIVIDUALS; SENSITIVITY; ALGORITHMS; FAILURE; CENTERS AB The availability of reliable human immunodeficiency virus types 1 and 2 (HIV-1/2) rapid tests in resource-limited settings represents an important advancement in the accurate diagnosis of HIV infection and presents opportunities for implementation of effective prevention and treatment interventions among vulnerable populations. A study of the potential target populations for future HIV vaccine studies examined the prevalence of HIV infections at six selected sites in Nigeria and evaluated the use of two rapid diagnostic tests (RDTs) for HIV. The populations included market workers at sites adjacent to military installations and workers at highway settlements (truck stops) who may have a heightened risk of HIV exposure. Samples from 3,187 individuals who provided informed consent were tested in parallel using the Determine (DT) and Stat-Pak (SP) RDTs; discordant results were subjected to the Uni-Gold (UG) RDT as a tiebreaker. The results were compared to those of a third-generation enzyme immunoassay screen with confirmation of repeat reactive samples by HIV-1 Western blotting. One participant was HIV-2 infected, yielding positive results on both RDTs. Using the laboratory algorithm as a gold standard, we calculated sensitivities of 98.5% (confidence interval [CI], 97.1 to 99.8%) for DT and 98.1% (CI, 96.7 to 99.6%) for SP and specificities of 98.7% (CI, 98.3 - 99.1%) for DT and 99.8% (CI, 99.6 to 100%) for SP. Similar results were obtained when the sites were stratified into those of higher HIV prevalence (9.4% to 22.8%) versus those of lower prevalence (3.2% to 7.3%). A parallel two-test algorithm requiring both DT and SP to be positive resulted in the highest sensitivity (98.1%; CI, 96.7 to 99.6%) and specificity (99.97%; CI, 99.9 to 100%) relative to those for the reference laboratory algorithm. C1 [Manak, Mark M.; Shutt, Ashley; Milazzo, Mark] Henry Jackson Fdn, MHRP HJF, Silver Spring, MD USA. [Njoku, Ogbonnaya S.; Suleiman, Aminu; Ogundeji, Amos A.; Nelson, Robert; Ayemoba, Ojor R.] US Mil HIV Res Program HJF MRI, Abuja, Nigeria. [Malia, Jennifer; Jagodzinski, Linda L.; Michael, Nelson L.; Peel, Sheila A.] MHRP WRAIR, Walter Reed Army Inst Res, Silver Spring, MD USA. [O'Connell, Robert J.] AFRIMS, Bangkok, Thailand. [Singer, Darrell E.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Manak, MM (reprint author), Henry Jackson Fdn, MHRP HJF, Silver Spring, MD USA. EM mmanak@hivresearch.org OI Manak, Mark /0000-0002-9217-9129 FU Henry M. Jackson Foundation [W81XWH-07-2-0067]; U.S. Department of Defense (DOD) FX This work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD). NR 29 TC 3 Z9 4 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD NOV PY 2015 VL 53 IS 11 BP 3501 EP 3506 DI 10.1128/JCM.01432-15 PG 6 WC Microbiology SC Microbiology GA CX3UY UT WOS:000365626200019 PM 26311857 ER PT J AU Reiter, MJ Costello, JE Schwope, RB Lisanti, CJ Osswald, MB AF Reiter, Michael J. Costello, Justin E. Schwope, Ryan B. Lisanti, Christopher J. Osswald, Michael B. TI Review of Commonly Used Serum Tumor Markers and Their Relevance for Image Interpretation SO JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY LA English DT Review DE serum tumor marker; cancer; CT; MRI ID MEDICINE PRACTICE GUIDELINES; CLINICAL-PRACTICE GUIDELINE; STAGE OVARIAN-CANCER; GERM-CELL TUMORS; HEPATOCELLULAR-CARCINOMA; CARCINOEMBRYONIC ANTIGEN; COLORECTAL-CANCER; PROSTATE-CANCER; AMERICAN SOCIETY; PANCREATIC ADENOCARCINOMA AB Serum tumor markers are firmly entrenched as one of the primary tools in an oncologist's armamentarium. They can be implemented in a broad range of applications from diagnostic assistance, assessing prognosis, or guiding therapeutic decisions. However, tumor markers also have limitations, which significantly impact how they should be used. Radiologists should be familiar with the following most prevalent tumor markers, which will all be discussed here: prostate-specific antigen (prostate), carcinoembryonic antigen (colon), -fetoprotein (hepatocellular and testicular), carbohydrate antigen 19.9 (pancreas), cancer antigen 125 (ovarian), human chorionic gonadotropin/lactic dehydrogenase (testicular), and chromogranin A (neuroendocrine). This knowledge should avoid needless intervention, enhance image interpretation, and ultimately provide optimal patient care. C1 [Reiter, Michael J.] SUNY Stony Brook, Med Ctr, Dept Radiol, Stony Brook, NY 11794 USA. [Costello, Justin E.; Schwope, Ryan B.; Lisanti, Christopher J.] Brooke Army Med Ctr, Dept Radiol, San Antonio, TX USA. [Schwope, Ryan B.; Lisanti, Christopher J.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Osswald, Michael B.] Brooke Army Med Ctr, Dept Oncol, San Antonio, TX USA. RP Reiter, MJ (reprint author), SUNY Stony Brook, Med Ctr, Dept Radiol, HSC Level 4,Room 120,East Loop Rd, Stony Brook, NY 11794 USA. EM mikereiter13@yahoo.com NR 77 TC 3 Z9 4 U1 3 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0363-8715 EI 1532-3145 J9 J COMPUT ASSIST TOMO JI J. Comput. Assist. Tomogr. PD NOV-DEC PY 2015 VL 39 IS 6 BP 825 EP 834 DI 10.1097/RCT.0000000000000297 PG 10 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA CX3PC UT WOS:000365610300001 PM 26248153 ER PT J AU Zarndt, BS Buchta, JN Garver, LS Davidson, SA Rowton, ED Despain, KE AF Zarndt, Bethany S. Buchta, Jessica N. Garver, Lindsey S. Davidson, Silas A. Rowton, Edgar D. Despain, Kenneth E. TI Use of a Far-Infrared Active Warming Device in Guinea Pigs (Cavia porcellus) SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE LA English DT Article ID KETAMINE-XYLAZINE ANESTHESIA; MOUSE; RATS AB Small mammals have difficulty maintaining body temperature under anesthesia. This hypothermia is a potential detriment not only to the health and comfort of the animal but also to the integrity of any treatment given or data gathered during the anesthetic period. Using an external warming device to assist with temperature regulation can mitigate these effects. In this study, we investigated the ability of an advanced warming device that uses far-infrared (FIR) heating and responds to real-time core temperature monitoring to maintain a normothermic core temperature in guinea pigs. Body temperatures were measured during 30 min of ketamine-xylazine general anesthesia with and without application of the heating device. The loss of core body heat from anesthetized guinea pigs under typical (unwarmed) conditions was significant, and this loss was almost completely mitigated by application of the FIR heating pad. The significant difference between the temperatures of the actively warmed guinea pigs as compared with the control group began as early as 14 min after anesthetic administration, leading to a 2.6 degrees C difference at 30 min. Loss of core body temperature was not correlated with animals' body weight; however, weight influences the efficiency of FIR warming slightly. These study results show that the FIR heating device accurately controls core body temperature in guinea pigs, therefore potentially alleviating the effects of body heat loss on animal physiology. C1 [Zarndt, Bethany S.; Buchta, Jessica N.; Despain, Kenneth E.] Walter Reed Army Inst Res, Vet Med, Silver Spring, MD 20910 USA. [Garver, Lindsey S.; Davidson, Silas A.; Rowton, Edgar D.] Walter Reed Army Inst Res, Entomol Div, Silver Spring, MD USA. RP Zarndt, BS (reprint author), Walter Reed Army Inst Res, Vet Med, Silver Spring, MD 20910 USA. EM bethany.s.zarndt.mil@mail.mil NR 16 TC 0 Z9 0 U1 1 U2 2 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1559-6109 J9 J AM ASSOC LAB ANIM JI J. Amer. Assoc. Lab. Anim. Sci. PD NOV PY 2015 VL 54 IS 6 BP 779 EP 782 PG 4 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA CX8EF UT WOS:000365934700012 PM 26632788 ER PT J AU Hoverson, K Wohltmann, WE Pollack, RJ Schissel, DJ AF Hoverson, Kara Wohltmann, Wendi E. Pollack, Richard J. Schissel, Daniel J. TI Dermestid Dermatitis in a 2-Year-Old Girl: Case Report and Review of the Literature SO PEDIATRIC DERMATOLOGY LA English DT Article ID BEETLE LARVAL PARTS; MACULATUS-DEGEER; CARPET; BUG AB Dermatitis from contact with carpet, larder, and hide beetles (family Dermestidae) is a seemingly uncommon or underrecognized hypersensitivity reaction to the specialized hairs on the larvae of certain dermestid beetles. The erythematous papulovesicular dermatitis that may result from such contact can be mistakenly construed as evidence of bites of bedbugs or other arthropods or infestation with scabies mites or can be the basis for a diagnosis of delusory parasitosis. We present a case of dermestid dermatitis in a 2-year-old girl and provide a review of the current literature. C1 [Hoverson, Kara] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Wohltmann, Wendi E.] Univ Colorado, Dept Pathol, Denver, CO USA. [Wohltmann, Wendi E.] Univ Colorado, Dept Dermatol, Denver, CO USA. [Pollack, Richard J.] Harvard TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA USA. [Pollack, Richard J.] IdentifyUS, Newton, MA USA. [Schissel, Daniel J.] Landstuhl Reg Med Ctr, Dept Dermatol, Landstuhl, Germany. RP Hoverson, K (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM kara.hoverson@gmail.com NR 24 TC 1 Z9 1 U1 2 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0736-8046 EI 1525-1470 J9 PEDIATR DERMATOL JI Pediatr. Dermatol. PD NOV-DEC PY 2015 VL 32 IS 6 BP e228 EP e233 DI 10.1111/pde.12641 PG 6 WC Dermatology; Pediatrics SC Dermatology; Pediatrics GA CX2KQ UT WOS:000365526000001 PM 26250481 ER PT J AU Bradford, LS AF Bradford, Lonnie S. TI Misconceptions About Traumatic Brain Injury Among US Army Behavioral Health Professionals SO REHABILITATION PSYCHOLOGY LA English DT Article DE traumatic brain injury; military; concussion; misconceptions ID MILD HEAD-INJURY; POSTCONCUSSIVE SYMPTOMS; NEUROPSYCHOLOGICAL OUTCOMES; COMMON MISCONCEPTIONS; COGNITIVE SEQUELAE; CONCUSSION; BLAST; METAANALYSIS; EXPECTATION; KNOWLEDGE AB Purpose/Objective: To investigate the knowledge and misconceptions about traumatic brain injury (TBI) held by behavioral health care professionals providing services to an active-duty military population. Research Method/Design: Active duty U.S. Army psychologists, psychiatrists, social workers, and psychiatric nurses from locations across the Department of Defense, and behavioral health professionals from a major military hospital (N = 181) were surveyed on 19 common myths and misconceptions about TBI (Gouvier, Prestholdt, & Warner, 1988). Eight new items were added to the survey to more specifically assess misconceptions pertaining to mild TBI (mTBI). Results: Mean percentages for the subcomponents of the questionnaire suggested that responses were generally accurate for general information about brain damage (83.61% correct) but less accurate for unconsciousness (45.81%), amnesia or memory loss (53%), and recovery items (64.8%). The total percent correct was 51% on the new mTBI items with a sizable minority of the sample viewing mTBI as being associated with lengthier recovery and poorer outcome than what has been indicated by recent research. Conclusion/Implications: Overall, misconceptions, particularly about mTBI, are prevalent among U.S. Army behavioral health providers. These findings raise concern about the dissemination of TBI information to health care professionals in the U.S. Army and to military personnel who may not be receiving accurate information about TBI recovery. C1 [Bradford, Lonnie S.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Bradford, LS (reprint author), Brooke Army Med Ctr, MCHE DBM, Neuropsychol Serv, 3551 Roger Brooke Dr,Bldg 3600, Ft Sam Houston, TX 78234 USA. EM lonnie.bradford@us.army.mil NR 40 TC 0 Z9 0 U1 1 U2 1 PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA SN 0090-5550 EI 1939-1544 J9 REHABIL PSYCHOL JI Rehabil. Psychol. PD NOV PY 2015 VL 60 IS 4 BP 344 EP 352 DI 10.1037/rep0000057 PG 9 WC Psychology, Clinical; Rehabilitation SC Psychology; Rehabilitation GA CX4YL UT WOS:000365706800005 PM 26436992 ER PT J AU Linden, K Scaravilli, V Kreyer, SFX Belenkiy, SM Stewart, IJ Chung, KK Cancio, LC Batchinsky, AI AF Linden, Katharina Scaravilli, Vittorio Kreyer, Stefan F. X. Belenkiy, Slava M. Stewart, Ian J. Chung, Kevin K. Cancio, Leopoldo C. Batchinsky, Andriy I. TI EVALUATION OF THE CYTOSORB (TM) HEMOADSORPTIVE COLUMN IN A PIG MODEL OF SEVERE SMOKE AND BURN INJURY SO SHOCK LA English DT Article DE Blood purification; burns; cytokine removal; hemoadsorption; myoglobin removal; respiratory failure ID RESPIRATORY-DISTRESS-SYNDROME; ACUTE KIDNEY INJURY; RANDOMIZED CONTROLLED-TRIAL; SHORT-TERM SURVIVAL; BLOOD PURIFICATION; CYTOKINE REMOVAL; CASE SERIES; SEPSIS; RHABDOMYOLYSIS; IMMUNOSUPPRESSION AB Introduction: Host inflammatory response to any form of tissue injury, including burn, trauma, or shock, has been well documented. After significant burns, cytokines can increase substantially within the first 24h after injury and may contribute to subsequent organ failure. Hemoadsorption by cytokine-adsorbing columns may attenuate this maladaptive response, thereby improving outcomes. The aim of this study was to investigate the feasibility, technical safety, and efficacy of cytokine and myoglobin removal by early use of a cytokine absorbing column (CytoSorb) in a porcine model of smoke inhalation and burn injury. Methods: Anesthetized female Yorkshire pigs (n=15) were injured by wood bark smoke inhalation and a 40% total body surface area deep burn and observed for 72h or death. The animals were randomized to hemoadsorption treatment (n=9) or a sham group (n=6) before injury. A 6-h hemoadsorption or sham session was performed on days one, two, and three. Serum cytokines (IL-1b, IL-6, IL-8, IL-10, TNF-alpha) and myoglobin were measured systemically, locally in bronchoalveolar lavage fluid and also in circulating blood before and after the adsorbing column to evaluate single pass clearance by the device. Results: Hemoadsorption caused significant removal of IL-1b, IL-6, IL-10, and myoglobin across the device mainly during the first run, ranging from 22% for IL-6 to 29% for IL-1b and 41% removal rates for myoglobin after 15min of treatment. Systemic cytokine or myoglobin serum concentrations did not change. Conclusions: In a porcine model of smoke and burn injury, hemoadsorption using the CytoSorb cartridge did not result in significant systemic or pulmonary reductions in the measured cytokines or myoglobin despite efficient transmembrane reductions. Further investigations are needed to optimize the efficiency of mediator clearance to affect both circulating levels and clinically relevant outcomes. C1 [Linden, Katharina; Scaravilli, Vittorio; Kreyer, Stefan F. X.; Belenkiy, Slava M.; Chung, Kevin K.; Cancio, Leopoldo C.; Batchinsky, Andriy I.] US Army, Inst Surg Res, Houston, TX USA. [Chung, Kevin K.; Cancio, Leopoldo C.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Stewart, Ian J.] San Antonio Mil Med Ctr, San Antonio, TX USA. [Linden, Katharina] Univ Hosp Bonn, Dept Pediat Cardiol, D-53113 Bonn, Germany. [Scaravilli, Vittorio] Univ Milano Bicocca, Dipartimento Sci Salute, Monza, Italy. [Kreyer, Stefan F. X.] Univ Hosp Bonn, Dept Anesthesiol & Intens Care Med, Bonn, Germany. RP Linden, K (reprint author), Univ Hosp Bonn, Dept Pediat Cardiol, Adenauerallee 119, D-53113 Bonn, Germany. EM Katharina.Linden@ukb.uni-bonn.de FU U.S. Army Medical Research and Materiel Command Small Business Innovative Research (SBIR) program [W81XWH-12-0038]; AFMFS grant FX This study was funded by a grant from the U.S. Army Medical Research and Materiel Command Small Business Innovative Research (SBIR) program, Contract number W81XWH-12-0038, to CytoSorbents Inc., Monmouth Junction, New Jersey. The institutions of KKC, IJS, and LCC received an AFMFS grant to examine CytoSorb in rhabdomyolysis. NR 35 TC 3 Z9 3 U1 2 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD NOV PY 2015 VL 44 IS 5 BP 487 EP 495 DI 10.1097/SHK.0000000000000439 PG 9 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA CX4LU UT WOS:000365673200015 PM 26368927 ER PT J AU Perkins, EJ Antczak, P Burgoon, L Falciani, F Garcia-Reyero, N Gutsell, S Hodges, G Kienzler, A Knapen, D McBride, M Willett, C AF Perkins, Edward J. Antczak, Philipp Burgoon, Lyle Falciani, Francesco Garcia-Reyero, Natalia Gutsell, Steve Hodges, Geoff Kienzler, Aude Knapen, Dries McBride, Mary Willett, Catherine TI Adverse Outcome Pathways for Regulatory Applications: Examination of Four Case Studies With Different Degrees of Completeness and Scientific Confidence SO TOXICOLOGICAL SCIENCES LA English DT Article DE mode of action; regulatory toxicology; risk assessment; hazard assessment; tox21 ID ENDOCRINE-DISRUPTING CHEMICALS; QUANTITATIVE RISK-ASSESSMENT; MINNOW PIMEPHALES-PROMELAS; EARLY FISH DEVELOPMENT; BASE-LINE TOXICITY; LYMPH-NODE ASSAY; SKIN SENSITIZATION; FATHEAD MINNOW; CONCEPTUAL-FRAMEWORK; ENVIRONMENTAL-POLLUTANTS AB Adverse outcome pathways (AOPs) offer a pathway-based toxicological framework to support hazard assessment and regulatory decision-making. However, little has been discussed about the scientific confidence needed, or how complete a pathway should be, before use in a specific regulatory application. Here we review four case studies to explore the degree of scientific confidence and extent of completeness (in terms of causal events) that is required for an AOP to be useful for a specific purpose in a regulatory application: (i) Membrane disruption (Narcosis) leading to respiratory failure (low confidence), (ii) Hepatocellular proliferation leading to cancer (partial pathway, moderate confidence), (iii) Covalent binding to proteins leading to skin sensitization (high confidence), and (iv) Aromatase inhibition leading to reproductive dysfunction in fish (high confidence). Partially complete AOPs with unknown molecular initiating events, such as 'Hepatocellular proliferation leading to cancer', were found to be valuable. We demonstrate that scientific confidence in these pathways can be increased though the use of unconventional information (eg, computational identification of potential initiators). AOPs at all levels of confidence can contribute to specific uses. A significant statistical or quantitative relationship between events and/or the adverse outcome relationships is a common characteristic of AOPs, both incomplete and complete, that have specific regulatory uses. For AOPs to be useful in a regulatory context they must be at least as useful as the tools that regulators currently possess, or the techniques currently employed by regulators. C1 [Perkins, Edward J.; Burgoon, Lyle] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Antczak, Philipp; Falciani, Francesco] Univ Liverpool, Inst Integrat Biol, Liverpool L69 3BX, Merseyside, England. [Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS USA. [Gutsell, Steve; Hodges, Geoff] Unilever, Sharnbrook MK44 1LQ, Beds, England. [Kienzler, Aude] JRC Inst Hlth & Consumer Protect, Ispra, Italy. [Knapen, Dries] Univ Antwerp, Zebrafishlab, B-2610 Antwerp, Belgium. [McBride, Mary] Agilent Technol, Washington, DC USA. [Willett, Catherine] Humane Soc United States, Washington, DE USA. RP Perkins, EJ (reprint author), US Army Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM edward.j.perkins@usace.army.mil OI Burgoon, Lyle/0000-0003-4977-5352; Knapen, Dries/0000-0003-0472-8114 FU American Chemistry Council; BioDetection Systems; European Centre for Ecotoxicology and Toxicology of Chemicals; Environment Canada; European Commission Directorate General Joint Research Center; Human Toxicology Project Consortium; International Life Sciences Institute-Health and Environmental Science Institute; Research Council of Norway [221455]; Society for Environmental Toxicology and Chemistry; U.S. Army Engineer Research and Development Center; U.S. Environmental Protection Agency FX Support for the workshop was provided by the American Chemistry Council, BioDetection Systems, European Centre for Ecotoxicology and Toxicology of Chemicals, Environment Canada, European Commission Directorate General Joint Research Center, Human Toxicology Project Consortium, International Life Sciences Institute-Health and Environmental Science Institute, the Research Council of Norway (221455), Society for Environmental Toxicology and Chemistry, U.S. Army Engineer Research and Development Center, and the U.S. Environmental Protection Agency. NR 91 TC 7 Z9 8 U1 7 U2 32 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 EI 1096-0929 J9 TOXICOL SCI JI Toxicol. Sci. PD NOV PY 2015 VL 148 IS 1 BP 14 EP 25 DI 10.1093/toxsci/kfv181 PG 12 WC Toxicology SC Toxicology GA CX2SU UT WOS:000365547900003 PM 26500288 ER PT J AU Matson, LM Grahame, NJ AF Matson, Liana M. Grahame, Nicholas J. TI Emotional reactivity to incentive downshift as a correlated response to selection of high and low alcohol preferring mice and an influencing factor on ethanol intake SO ALCOHOL LA English DT Article DE Frustration; Alcoholism; Genetic correlation; Alcohol preference; Motivation ID STRESSFUL LIFE EVENTS; NEGATIVE CONTRAST; CONSUMMATORY BEHAVIOR; DRINKING MOTIVES; RATS; PREFERENCE; ANXIETY; CHLORDIAZEPOXIDE; SENSITIVITY; LEWIS AB Losing a job or significant other are examples of incentive loss that result in negative emotional reactions. The occurrence of negative life events is associated with increased drinking (Keyes, Hatzenbuehler, & Hasin, 2011). Further, certain genotypes are more likely to drink alcohol in response to stressful negative life events (Blomeyer et al., 2008; Covault et al., 2007). Shared genetic factors may contribute to alcohol drinking and emotional reactivity, but this relationship is not currently well understood. We used an incentive downshift paradigm to address whether emotional reactivity is elevated in mice predisposed to drink alcohol. We also investigated if ethanol drinking is influenced in High Alcohol Preferring mice that had been exposed to an incentive downshift. Incentive downshift procedures have been widely utilized to model emotional reactivity, and involve shifting a high reward group to a low reward and comparing the shifted group to a consistently rewarded control group. Here, we show that replicate lines of selectively bred High Alcohol Preferring mice exhibited larger successive negative contrast effects than their corresponding replicate Low Alcohol Preferring lines, providing strong evidence for a genetic association between alcohol drinking and susceptibility to the emotional effects of negative contrast. These mice can be used to study the shared neurological and genetic underpinnings of emotional reactivity and alcohol preference. Unexpectedly, an incentive downshift suppressed ethanol drinking immediately following an incentive downshift. This could be due to a specific effect of negative contrast on ethanol consumption or a suppressive effect on consummatory behavior in general. These data suggest that either alcohol intake does not provide the anticipated negative reinforcement, or that a single test was insufficient for animals to learn to drink following incentive downshift. However, the emotional intensity following incentive downshift provides initial evidence that this type of emotional reactivity may be a predisposing factor in alcoholism. (C) 2015 Elsevier Inc. All rights reserved. C1 [Matson, Liana M.; Grahame, Nicholas J.] Indiana Univ Purdue Univ, Dept Psychol, Indianapolis, IN 46202 USA. [Matson, Liana M.] US Army, Med Res Inst Chem Def, Physiol & Immunol Res Div, Aberdeen Proving Ground, MD 21010 USA. RP Grahame, NJ (reprint author), IUPUI, Dept Psychol, 402 N Blackford St,LD120F, Indianapolis, IN 46202 USA. EM ngrahame@iupui.edu FU NIAAA [P60AA07611, T32AA07462] FX The authors would like to thank Amy Buckingham, Elizabeth Tombers, Robin Zimmer, Chrissie Best, and Candace Roberson for their technical assistance. LM and NG were responsible for the study concept and design, data analysis, interpretation of the findings, and critical review of this manuscript. LM contributed to the acquisition of animal data. These experiments were conducted as part of LM's dissertation thesis. This study was supported by NIAAA P60AA07611 to PI: David Crabb, and NIAAA T32AA07462 to PI: William McBride and Cristine Czachowski. NR 35 TC 1 Z9 1 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0741-8329 EI 1873-6823 J9 ALCOHOL JI Alcohol PD NOV PY 2015 VL 49 IS 7 BP 657 EP 664 DI 10.1016/j.alcohol.2015.08.002 PG 8 WC Substance Abuse; Pharmacology & Pharmacy; Toxicology SC Substance Abuse; Pharmacology & Pharmacy; Toxicology GA CX0HK UT WOS:000365377300004 PM 26404495 ER PT J AU Michelson, DG Tong, W Shoop, BL AF Michelson, David G. Tong, Wen Shoop, Barry L. TI COMMUNICATIONS EDUCATION AND TRAINING: ETHICS AND PROFESSIONALISM SO IEEE COMMUNICATIONS MAGAZINE LA English DT Editorial Material C1 [Michelson, David G.] Univ British Columbia, Dept Elect & Comp Engn, Vancouver, BC V5Z 1M9, Canada. [Tong, Wen] Huawei Technol, Shenzhen, Peoples R China. [Shoop, Barry L.] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, PA USA. RP Michelson, DG (reprint author), Univ British Columbia, Dept Elect & Comp Engn, Vancouver, BC V5Z 1M9, Canada. EM davem@ece.ubc.ca; tongwen@huawei.com; Barry.Shoop@usma.edu NR 0 TC 1 Z9 1 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0163-6804 EI 1558-1896 J9 IEEE COMMUN MAG JI IEEE Commun. Mag. PD NOV PY 2015 VL 53 IS 11 BP 16 EP 17 PG 2 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA CW4OW UT WOS:000364972000002 ER PT J AU Stamford, JA Schmidt, PN Friedl, KE AF Stamford, Jonathan A. Schmidt, Peter N. Friedl, Karl E. TI What Engineering Technology Could Do for Quality of Life in Parkinson's Disease: A Review of Current Needs and Opportunities SO IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS LA English DT Article DE Activity; cognition; depression; exercise; nonmotor symptoms; patient perspective; review article; sleep quality ID RANDOMIZED CONTROLLED-TRIAL; VIRTUAL HOUSE CALLS; PHYSICAL-ACTIVITY; NONMOTOR SYMPTOMS; ENERGY-EXPENDITURE; WEARABLE SENSORS; RATING-SCALE; SLEEP; EXERCISE; DEPRESSION AB Parkinson's disease (PD) involves well-known motor symptoms such as tremor, rigidity, bradykinesia, and altered gait, but there are also nonlocomotory motor symptoms (e.g., changes in handwriting and speech) and even nonmotor symptoms (e.g., disrupted sleep, depression) that can be measured, monitored, and possibly better managed through activity-based monitoring technologies. This will enhance quality of life (QoL) in PD through improved self-monitoring and also provide information that could be shared with a healthcare provider to help better manage treatment. Until recently, nonmotor symptoms ("soft signs") had been generally overlooked in clinical management, yet these are of primary importance to patients and their QoL. Day-to-day variability of the condition, the high variability in symptoms between patients, and the isolated snapshots of a patient in periodic clinic visits make better monitoring essential to the proper management of PD. Continuously monitored patterns of activity, social interactions, and daily activities could provide a rich source of information on status changes, guiding self-correction and clinical management. The same tools can be useful in earlier detection of PD and will improve clinical studies. Remote medical communications in the form of telemedicine, sophisticated tracking of medication use, and assistive technologies that directly compensate for disease-related challenges are examples of other near-term technology solutions to PD problems. Ultimately, a sensor technology is not good if it is not used. The Parkinson's community is a sophisticated early adopter of useful technologies and a group for which engineers can provide near-term gratifying benefits. C1 [Stamford, Jonathan A.] Parkinsons Movement, London W1U 6TU, England. [Schmidt, Peter N.] Natl Parkinsons Fdn, Miami, FL 33131 USA. [Friedl, Karl E.] US Army Res Inst Environm Med, Natick, MA 01760 USA. [Friedl, Karl E.] Univ Calif San Francisco, San Francisco, CA 94143 USA. RP Stamford, JA (reprint author), Parkinsons Movement, London W1U 6TU, England. EM jon.stamford@parkisonsmovement.com; pschmidt@parkinson.org; karl.friedl@nih.gov OI Friedl, Karl/0000-0002-3134-8427 NR 109 TC 6 Z9 7 U1 7 U2 26 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 2168-2194 J9 IEEE J BIOMED HEALTH JI IEEE J. Biomed. Health Inform. PD NOV PY 2015 VL 19 IS 6 BP 1862 EP 1872 DI 10.1109/JBHI.2015.2464354 PG 11 WC Computer Science, Information Systems; Computer Science, Interdisciplinary Applications; Mathematical & Computational Biology; Medical Informatics SC Computer Science; Mathematical & Computational Biology; Medical Informatics GA CW2XS UT WOS:000364857000011 PM 26259205 ER PT J AU Ozdemir, O Wimalajeewa, T Dulek, B Varshney, PK Su, W AF Ozdemir, Onur Wimalajeewa, Thakshila Dulek, Berkan Varshney, Pramod K. Su, Wei TI Asynchronous Linear Modulation Classification With Multiple Sensors via Generalized EM Algorithm SO IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS LA English DT Article DE Modulation classification; hybrid maximum likelihood; generalized expectation maximization algorithm; data fusion; multiple sensors ID MAXIMUM-LIKELIHOOD; SIGNALS AB In this paper, we consider the problem of automatic modulation classification with multiple sensors in the presence of unknown time offset, phase offset and received signal amplitude. We develop a novel hybrid maximum likelihood (HML) classification scheme based on a generalized expectation maximization (GEM) algorithm. GEM is capable of finding ML estimates numerically that are extremely hard to obtain otherwise. Assuming a good initialization technique is available for GEM, we show that the classification performance (in terms of the probability of error) can be greatly improved with multiple sensors compared to that with a single sensor, especially when the signal-to-noise ratio (SNR) is low. We further demonstrate the superior performance of our approach when simulated annealing (SA) with uniform as well as nonuniform grids is employed for initialization of GEM in low SNR regions. The proposed GEM based approach employs only a small number of samples (in the order of hundreds) at a given sensor node to perform both time and phase synchronization, signal power estimation, followed by modulation classification. We provide simulation results to show the efficiency and effectiveness of the proposed algorithm. C1 [Ozdemir, Onur] ANDRO Computat Solut, Rome, NY 13440 USA. [Wimalajeewa, Thakshila; Varshney, Pramod K.] Syracuse Univ, Dept Elect Engn & Comp Sci EECS, Syracuse, NY 13210 USA. [Dulek, Berkan] Hacettepe Univ, Dept Elect & Elect Engn, TR-06532 Ankara, Turkey. [Su, Wei] US Army Commun Elect Res, Dev & Engn Ctr CERDEC, Aberdeen Proving Ground, MD 21005 USA. RP Ozdemir, O (reprint author), Boston Fus Corp, Burlington, MA 01803 USA. EM oozdemir@syr.edu; twwewelw@syr.edu; berkan@ee.hacettepe.edu.tr; varshney@syr.edu; wei.su.civ@mail.mil FU US Government FX This material is in part based upon work supported by the US Government. US Government Distribution Statement A: Public Release Unlimited. The associate editor coordinating the review of this paper and approving it for publication was Y. Xin. NR 21 TC 2 Z9 2 U1 1 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1536-1276 EI 1558-2248 J9 IEEE T WIREL COMMUN JI IEEE Trans. Wirel. Commun. PD NOV PY 2015 VL 14 IS 11 BP 6389 EP 6400 DI 10.1109/TWC.2015.2453269 PG 12 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA CW5OP UT WOS:000365046100038 ER PT J AU Phanuphak, N Lo, YR Shao, YM Solomon, SS O'Connell, RJ Tovanabutra, S Chang, D Kim, JH Excler, JL AF Phanuphak, Nittaya Lo, Ying-Ru Shao, Yiming Solomon, Sunil Suhas O'Connell, Robert J. Tovanabutra, Sodsai Chang, David Kim, Jerome H. Excler, Jean Louis TI HIV Epidemic in Asia: Implications for HIV Vaccine and Other Prevention Trials SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Review ID CIRCULATING RECOMBINANT FORM; IMMUNODEFICIENCY-VIRUS TYPE-1; MIDDLE-INCOME COUNTRIES; INJECTING DRUG-USERS; CHINA-MYANMAR BORDER; FEMALE SEX WORKERS; SOUTH-EAST ASIA; SUBTYPE-C; ANTIRETROVIRAL TREATMENT; PREEXPOSURE PROPHYLAXIS AB An overall decrease of HIV prevalence is now observed in several key Asian countries due to effective prevention programs. The decrease in HIV prevalence and incidence may further improve with the scale-up of combination prevention interventions. The implementation of future prevention trials then faces important challenges. The opportunity to identify heterosexual populations at high risk such as female sex workers may rapidly wane. With unabating HIV epidemics among men who have sex with men (MSM) and transgender (TG) populations, an effective vaccine would likely be the only option to turn the epidemic. It is more likely that efficacy trials will occur among MSM and TG because their higher HIV incidence permits smaller and less costly trials. The constantly evolving patterns of HIV-1 diversity in the region suggest close monitoring of the molecular HIV epidemic in potential target populations for HIV vaccine efficacy trials. CRF01_AE remains predominant in southeast Asian countries and MSM populations in China. This relatively steady pattern is conducive to regional efficacy trials, and as efficacy warrants, to regional licensure. While vaccines inducing nonneutralizing antibodies have promise against HIV acquisition, vaccines designed to induce broadly neutralizing antibodies and cell-mediated immune responses of greater breadth and depth in the mucosal compartments should be considered for testing in MSM and TG. The rationale and design of efficacy trials of combination prevention modalities such as HIV vaccine and preexposure prophylaxis (PrEP) remain hypothetical, require high adherence to PrEP, are more costly, and present new regulatory challenges. The prioritization of prevention interventions should be driven by the HIV epidemic and decided by the country-specific health and regulatory authorities. Modeling the impact and cost-benefit may help this decision process. C1 [Phanuphak, Nittaya] Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, Thailand. [Lo, Ying-Ru] WHO Reg Off Western Pacific, HIV Hepatitis & STI Unit, Manila, Philippines. [Shao, Yiming] Chinese Ctr Dis Control & Prevent, Natl Ctr AIDS STD Control & Prevent, Beijing, Peoples R China. [Solomon, Sunil Suhas] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Solomon, Sunil Suhas] YR Gaitonde Ctr AIDS Res & Educ YRG CARE, Madras, Tamil Nadu, India. [O'Connell, Robert J.] Armed Forces Inst Med Sci AFRIMS, US Army Med Component, Dept Retrovirol, Bangkok, Thailand. [Tovanabutra, Sodsai; Chang, David; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Excler, Jean Louis] US Mil HIV Res Program, Bethesda, MD 20817 USA. [Excler, Jean Louis] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. RP Excler, JL (reprint author), US Mil HIV Res Program, 6720-A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA. EM jexcler@hivresearch.org FU U.S. Army Medical Research and Materiel Command (USAMRMC) [Y1-AI-2642-12]; National Institutes of Allergy and Infectious Diseases [Y1-AI-2642-12]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DOD) [W81XWH-07-2-0067] FX The preparation of this article was supported in part by an Interagency Agreement Y1-AI-2642-12 between the U.S. Army Medical Research and Materiel Command (USAMRMC) and the National Institutes of Allergy and Infectious Diseases. In addition, this work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD). NR 195 TC 4 Z9 4 U1 5 U2 9 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV 1 PY 2015 VL 31 IS 11 BP 1060 EP 1076 DI 10.1089/aid.2015.0049 PG 17 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA CV5SJ UT WOS:000364331100003 PM 26107771 ER PT J AU Karasavvas, N Karnasuta, C Savadsuk, H Madnote, S Inthawong, D Chantakulkij, S Rittiroongrad, S Nitayaphan, S Pitisuttithum, P Thongcharoen, P Siriyanon, V Andrews, CA Barnett, SW Tartaglia, J Sinangil, F Francis, DP Robb, ML Michael, NL Ngauy, V de Souza, MS Paris, RM Excler, JL Kim, JH O'Connell, RJ AF Karasavvas, Nicos Karnasuta, Chitraporn Savadsuk, Hathairat Madnote, Sirinan Inthawong, Dutsadee Chantakulkij, Somsak Rittiroongrad, Surawach Nitayaphan, Sorachai Pitisuttithum, Punnee Thongcharoen, Prasert Siriyanon, Vinai Andrews, Charla A. Barnett, Susan W. Tartaglia, James Sinangil, Faruk Francis, Donald P. Robb, Merlin L. Michael, Nelson L. Ngauy, Viseth de Souza, Mark S. Paris, Robert M. Excler, Jean-Louis Kim, Jerome H. O'Connell, Robert J. CA MOPH-TAVEG Collaboration TI IgG Antibody Responses to Recombinant gp120 Proteins, gp70V1/V2 Scaffolds, and a CyclicV2 Peptide in Thai Phase I/II Vaccine Trials Using Different Vaccine Regimens SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID PANDEMIC INFLUENZA VACCINE; ALVAC-HIV VCP1521; EFFICACY TRIAL; CANARYPOX VACCINE; IMMUNE-RESPONSES; IMMUNOGENICITY; SAFETY; COMBINATION; ADJUVANT; AIDSVAX AB RV144 correlates of risk analysis showed that IgG antibodies to gp70V1V2 scaffolds inversely correlated with risk of HIV acquisition. We investigated IgG antibody responses in RV135 and RV132, two ALVAC-HIV prime-boost vaccine trials conducted in Thailand prior to RV144. Both trials used ALVAC-HIV (vCP1521) at 0, 1, 3, and 6 months and HIV-1gp120MNgD and gp120A244gD in alum (RV135) or gp120SF2 and gp120CM235 in MF59 (RV132) at 3 and 6 months. We assessed ELISA binding antibodies to the envelope proteins (Env) 92TH023, A244gD and MNgD, cyclicV2, and gp70V1V2 CaseA2 (subtype B) and 92TH023 (subtype CRF01_AE), and Env-specific IgG1 and IgG3. Antibody responses to gp120 A244gD, MNgD, and gp70V1V2 92TH023 scaffold were significantly higher in RV135 than in RV132. Antibodies to gp70V1V2 CaseA2 were detected only in RV135 vaccine recipients and IgG1 and IgG3 antibody responses to A244gD were significantly higher in RV135. IgG binding to gp70V1V2 CaseA2 and CRF01_AE scaffolds was higher with the AIDSVAX((R))B/E boost but both trials showed similar rates of antibody decline post-vaccination. MF59 did not result in higher IgG antibody responses compared to alum with the antigens tested. However, notable differences in the structure of the recombinant proteins and dosage used for immunizations may have contributed to the magnitude and specificity of IgG induced by the two trials. C1 [Karasavvas, Nicos; Karnasuta, Chitraporn; Savadsuk, Hathairat; Madnote, Sirinan; Inthawong, Dutsadee; Chantakulkij, Somsak; Rittiroongrad, Surawach; Nitayaphan, Sorachai; Ngauy, Viseth; de Souza, Mark S.; O'Connell, Robert J.] Armed Forces Res Inst Med Sci, Dept Retrovirol, Bangkok 10400, Thailand. [Pitisuttithum, Punnee] Mahidol Univ, Fac Trop Med, Bangkok, Thailand. [Thongcharoen, Prasert] Mahidol Univ, Siriraj Hosp, Fac Med, Bangkok 10700, Thailand. [Siriyanon, Vinai] Chiang Mai Univ, Res Inst Hlth Sci, Chiang Mai 50000, Thailand. [Andrews, Charla A.] Tech Resources Int, Bethesda, MD USA. [Barnett, Susan W.] Novartis Vaccines & Diagnost Inc, Cambridge, MA USA. [Tartaglia, James] Sanofi Pasteur, Swiftwater, PA USA. [Sinangil, Faruk; Francis, Donald P.] GSID, San Francisco, CA USA. [Robb, Merlin L.; Michael, Nelson L.; Excler, Jean-Louis] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Robb, Merlin L.; Excler, Jean-Louis] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Paris, Robert M.] Walter Reed Army Inst Res, Mil Malaria Res Program, Silver Spring, MD USA. [Kim, Jerome H.] Int Vaccine Inst, Seoul, South Korea. RP Karasavvas, N (reprint author), USAMC AFRIMS, Dept Retrovirol, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM karasavvan@afrims.org FU U.S. Army Medical Research and Materiel Command (USAMRMC) [Y1-AI-2642-12]; National Institute of Allergy and Infectious Diseases; Henry M. Jackson Foundation for the Advancement of Military Medicine [W81XWH-07-2-0067]; U.S. Department of Defense; U.S. National Institute of Allergy and Infectious Diseases FX These studies were supported in part by an Interagency Agreement Y1-AI-2642-12 between the U.S. Army Medical Research and Materiel Command (USAMRMC) and the National Institute of Allergy and Infectious Diseases. In addition, this work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the U.S. Department of Defense. This research was funded in part by the U.S. National Institute of Allergy and Infectious Diseases. NR 35 TC 2 Z9 2 U1 0 U2 3 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 EI 1931-8405 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV 1 PY 2015 VL 31 IS 11 BP 1178 EP 1186 DI 10.1089/aid.2015.0034 PG 9 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA CV5SJ UT WOS:000364331100015 PM 26234467 ER PT J AU Conlan, JV Vongxay, K Khamlome, B Jarman, RG Gibbons, RV Fenwick, SG Thompson, RCA Blacksell, SD AF Conlan, James V. Vongxay, Khamphouth Khamlome, Boualam Jarman, Richard G. Gibbons, Robert V. Fenwick, Stanley G. Thompson, R. C. A. Blacksell, Stuart D. TI Patterns of Flavivirus Seroprevalence in the Human Population of Northern Laos SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID JAPANESE ENCEPHALITIS-VIRUS; RISK-FACTORS; INFECTION; REGION; PIGS AB A total of 1,136 samples from 289 households in four provinces in northern Laos were subjected to Japanese encephalitis virus (JEV) and dengue virus hemagglutination inhibition (DENV HI). Overall, antibodies to JEV were detected by HI in 620 (54.6%) of 1,136 people; of which 217 (19.1%) had HI activity against JEV only. Antibodies to DENV4 were detected by HI in 526 (46.3%) of 1,136 people; of which 124 (10.9%) had HI activity against DENV4 only. Antibodies to DENV1-3 were detected by HI in 296 (26.1%), 274 (24.1%), and 283 (24.9) of 1,136 people, respectively; of which 7, 1, and 0, respectively, had HI activity against DENV1-3 only. JEV was the most prevalent Flavivirus in Oudomxay, Luangprabang, and Huaphan provinces and DENV4 was the most prevalent in Xiengkhouang province. Seroprevalence for JEV increased with increasing age and wealth and was higher in villages where rice was cultivated in paddy fields and highest for people of Lao-Tai ethnicity. C1 [Conlan, James V.; Thompson, R. C. A.] Murdoch Univ, Sch Vet & Life Sci, Murdoch, WA 6150, Australia. Minist Agr & Forestry, Div Vet Serv, Dept Livestock & Fisheries, Viangchan, Laos. [Khamlome, Boualam] Minist Hlth, Dept Communicable Dis Control, Viangchan, Laos. Armed Forces Res Inst Med Sci, US Army Med Component, Bangkok 10400, Thailand. Mahidol Univ, Mahidol Oxford Trop Med Res Unit, Fac Trop Med, Bangkok 10400, Thailand. Churchill Hosp, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford OX3 7LJ, England. [Conlan, James V.] Natl Anim Hlth Ctr, Dept Livestock & Fisheries, Vientiane Capital, Laos. [Vongxay, Khamphouth] Dept Livestock & Fisheries, Div Vet Serv, Viangchan, Laos. [Jarman, Richard G.; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Fenwick, Stanley G.] Murdoch Univ, Sch Vet & Biomed Sci, Murdoch, WA 6150, Australia. [Blacksell, Stuart D.] Mahidol Oxford Trop Med Res Unit, Wellcome Trust Mahosot Univ Oxford Trop Med Progr, Bangkok, Thailand. [Blacksell, Stuart D.] Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford, England. RP Blacksell, SD (reprint author), Mahidol Univ, Mahidol Oxford Trop Med Res Unit, Fac Trop Med, 420-6 Rajvithi Rd, Bangkok 10400, Thailand. EM j.conlan@murdoch.edu.au; khampouth.vongxay@fao.org; drboualamkham2013@yahoo.com; rick.jarman@us.army.mil; robert.v.gibbons2.mil@mail.mil; stanley.fenwick@tufts.edu; a.thompson@murdoch.edu.au; stuart@tropmedres.ac OI Blacksell, Stuart/0000-0001-6576-726X FU Australian Centre for International Agricultural Research (ACIAR); Wellcome Trust of the United Kingdom FX This study was funded by the Australian Centre for International Agricultural Research (ACIAR). Stuart D. Blacksell is funded by the Wellcome Trust of the United Kingdom. NR 19 TC 3 Z9 3 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2015 VL 93 IS 5 BP 1010 EP 1013 DI 10.4269/ajtmh.15-0072 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA CV7FJ UT WOS:000364437500021 PM 26304925 ER PT J AU Eick-Cost, AA Hu, Z Klein, TA Putnak, RJ Jarman, RG AF Eick-Cost, Angelia A. Hu, Zheng Klein, Terry A. Putnak, Robert J. Jarman, Richard G. TI Seroconversion to Japanese Encephalitis Virus among US Infantry Forces in Korea SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID REPUBLIC-OF-KOREA; IMMUNIZATION; VACCINES; FUTURE AB Japanese encephalitis virus (JEV) is endemic in the Republic of Korea (ROK), posing a medical threat to more than 29,000 U.S. Forces military personnel currently deployed in the ROK. The objective of this study was to provide data on the risk of JEV exposure among U.S. Forces in the ROK. One thousand U.S. Army Soldiers were randomly selected for the study from the cohort of infantry Soldiers deployed in the ROK for a period of at least 330 days from 2008 to 2011. Pre- and post-deployment serum specimens were tested for the presence of JEV antibodies by plaque reduction neutralization test. A total of 2/1,000 (0.2%) U.S. Army Soldiers post-deployment specimens tested positive for JEV antibody. Results from the pre-deployment specimens indicated one true seroconversion and one with titers suggestive of a JEV infection. These results indicate a low, but nonzero risk of JEV exposure among U.S. Army Soldiers in the ROK. C1 Armed Forces Hlth Surveillance Ctr, Epidemiol & Anal Div, Silver Spring, MD 20904 USA. [Klein, Terry A.] 65th Med Brigade, Force Hlth Protect & Prevent Med, Seoul, South Korea. Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA. [Eick-Cost, Angelia A.; Hu, Zheng] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD 20904 USA. [Putnak, Robert J.; Jarman, Richard G.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Eick-Cost, AA (reprint author), Armed Forces Hlth Surveillance Ctr, 11800 Tech Rd,Suite 220, Silver Spring, MD 20904 USA. EM angelia.a.cost.ctr@mail.mil; zheng.hu.ctr@mail.mil; terry.a.klein2.civ@mail.mil; j.r.putnak.ctr@mail.mil; richard.g.jarman.mil@mail.mil FU Armed Forces Health Surveillance Center, Division of Global Emerging Infections Surveillance and Response System FX This study was funded by the Armed Forces Health Surveillance Center, Division of Global Emerging Infections Surveillance and Response System. NR 16 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2015 VL 93 IS 5 BP 1052 EP 1054 DI 10.4269/ajtmh.15-0307 PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA CV7FJ UT WOS:000364437500028 PM 26240157 ER PT J AU Gray, DJ Anderson, J Nelson, J Edwards, J AF Gray, Deric J. Anderson, John Nelson, Jean Edwards, Jarrod TI Using a multiwavelength LiDAR for improved remote sensing of natural waters SO APPLIED OPTICS LA English DT Article ID VOLUME SCATTERING FUNCTION; THEORETICAL DERIVATION; OCEAN; REFLECTANCE; PROFILE; LIGHT; MODEL AB This paper describes research to characterize the benefits of a multiwavelength oceanographic LiDAR for various water types. Field measurements were conducted to establish endmembers representative of both typical and extremely challenging natural conditions. Laboratory tests were performed using a prototype multiwavelength LiDAR in water tanks with optical conditions simulating both sediment-laden and biologically rich water types. LiDAR models were used to simulate the LiDAR signal from both field and laboratory experiments. Our measurements and models show that using a laser wavelength of 470-490 nm in the open ocean leads to an improvement factor of 1.50-1.75 compared to a 532 nm system. In more turbid areas using a laser wavelength of 560 -580 nm leads to an improvement factor of 1.25. We conclude by demonstrating how using multiple LiDAR wavelengths can help detect and characterize constituents in the water column. (C) 2015 Optical Society of America C1 [Gray, Deric J.] US Naval Res Lab, Remote Sensing Div, Washington, DC 20375 USA. [Anderson, John; Nelson, Jean; Edwards, Jarrod] US Army Corps Engn, Engn Res & Dev Ctr, Geospatial Res Lab, Alexandria, VA 22315 USA. RP Gray, DJ (reprint author), US Naval Res Lab, Remote Sensing Div, Code 7231,4555 Overlook Ave S-W, Washington, DC 20375 USA. EM deric.gray@nrl.navy.mil FU National Geospatial-Intelligence Agency (NGA) [NIB8G41083GS37] FX National Geospatial-Intelligence Agency (NGA) (NIB8G41083GS37). NR 27 TC 0 Z9 0 U1 2 U2 11 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD NOV 1 PY 2015 VL 54 IS 31 BP F232 EP F242 DI 10.1364/AO.54.00F232 PG 11 WC Optics SC Optics GA CV7LY UT WOS:000364455800028 PM 26560612 ER PT J AU Crocker, F Indest, K Jung, C Hancock, D Fuller, M Hatzinger, P Vainberg, S Istok, J Wilson, E Michalsen, M AF Crocker, Fiona H. Indest, Karl J. Jung, Carina M. Hancock, Dawn E. Fuller, Mark E. Hatzinger, Paul B. Vainberg, Simon Istok, Jonathan D. Wilson, Edward Michalsen, Mandy M. TI Evaluation of microbial transport during aerobic bioaugmentation of an RDX-contaminated aquifer SO BIODEGRADATION LA English DT Article DE Microbial transport; Bioaugmentation; RDX; Hexahydro-1,3,5-trinitro-1,3,5-triazine; Groundwater ID HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE RDX; BIODEGRADATION; GROUNDWATER; DEGRADATION; BACTERIA; STRAINS; GENES; BIOREMEDIATION; RHODOCOCCUS AB In situ bioaugmentation with aerobic hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)-degrading bacteria is being considered for treatment of explosives-contaminated groundwater at Umatilla Chemical Depot, Oregon (UMCD). Two forced-gradient bacterial transport tests of site groundwater containing chloride or bromide tracer and either a mixed culture of Gordonia sp. KTR9 (xplA (+)Km(R)), Rhodococcus jostii RHA1 (pGKT2 transconjugant; xplA (+)Km(R)) and Pseudomonas fluorescens I-C (xenB (+)), or a single culture of Gordonia sp. KTR9 (xplA (+); i.e. wild-type) were conducted at UMCD. Groundwater monitoring evaluated cell viability and migration in the injection well and downgradient monitoring wells. Enhanced degradation of RDX was not evaluated in these demonstrations. Quantitative PCR analysis of xplA, the kanamycin resistance gene (aph), and xenB indicated that the mixed culture was transported at least 3 m within 2 h of injection. During a subsequent field injection of bioaugmented groundwater, strain KTR9 (wild-type) migrated up to 23-m downgradient of the injection well within 3 days. Thus, the three RDX-degrading strains were effectively introduced and transported within the UMCD aquifer. This demonstration represents an innovative application of bioaugmentation to potentially enhance RDX biodegradation in aerobic aquifers. C1 [Crocker, Fiona H.; Indest, Karl J.; Jung, Carina M.; Hancock, Dawn E.] US Army Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Fuller, Mark E.; Hatzinger, Paul B.; Vainberg, Simon] CB&I Fed Serv, Lawrenceville, NJ 08648 USA. [Istok, Jonathan D.] Oregon State Univ, Sch Civil & Construct Engn, Corvallis, OR 97331 USA. [Wilson, Edward; Michalsen, Mandy M.] US Army Corps Engineers, Environm Engn & Technol Sect, Seattle, WA 98134 USA. RP Crocker, F (reprint author), US Army Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Fiona.H.Crocker@usace.army.mil FU Environmental Security Technology Certification Program (ESTCP) [ER-201207] FX This project was supported by the Environmental Security Technology Certification Program (ESTCP) under project ER-201207 "Bioaugmentation for Bioremediation of Aerobic RDX-Contaminated Groundwater". Views, opinions, and/or findings contained in this report are those of the author(s) and should not be construed as an official Department of Defense position or decision unless so designated by other official documentation. NR 34 TC 2 Z9 2 U1 3 U2 11 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0923-9820 EI 1572-9729 J9 BIODEGRADATION JI Biodegradation PD NOV PY 2015 VL 26 IS 6 BP 443 EP 451 DI 10.1007/s10532-015-9746-1 PG 9 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA CV8EI UT WOS:000364512300003 PM 26438043 ER PT J AU Swab, JJ Vargas-Gonzalez, L Wilson, E Warner, E AF Swab, Jeffrey J. Vargas-Gonzalez, Lionel Wilson, Elizabeth Warner, Eric TI Properties and Performance of Polycrystalline Cubic Boron Nitride SO INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY LA English DT Article ID MECHANICAL-PROPERTIES AB Cubic boron nitride (CBN) is a lightweight (rho = 3.45 g/cm(3)) ceramic material that is harder than all materials except diamond. As harder ceramics tend to perform better as armor, this material is of interest to the military community. CBN is synthetically produced and is primarily used as an abrasive and in cutting tool applications. The properties (elastic modulus, strength, toughness, hardness, etc.) and ballistic performance of this material were determined and compared to a commercially available armor-grade boron carbide (B4C). C1 [Swab, Jeffrey J.; Vargas-Gonzalez, Lionel] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Wilson, Elizabeth] George Washington Univ, Sci & Engn Apprentice Program, Washington, DC 20052 USA. [Warner, Eric] Bowhead Sci & Technol LLC, Belcamp, MD 21017 USA. RP Swab, JJ (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM jeffrey.j.swab.civ@mail.mil OI Vargas-Gonzalez, Lionel/0000-0001-6500-1686 NR 12 TC 1 Z9 1 U1 5 U2 26 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1546-542X EI 1744-7402 J9 INT J APPL CERAM TEC JI Int. J. Appl. Ceram. Technol. PD NOV-DEC PY 2015 VL 12 SU 3 SI SI BP E74 EP E81 DI 10.1111/ijac.12380 PG 8 WC Materials Science, Ceramics SC Materials Science GA CW0WM UT WOS:000364710700011 ER PT J AU Adler, AB Bliese, PD Pickering, MA Hammermeister, J Williams, J Harada, C Csoka, L Holliday, B Ohlson, C AF Adler, Amy B. Bliese, Paul D. Pickering, Michael A. Hammermeister, Jon Williams, Jason Harada, Coreen Csoka, Louis Holliday, Bernie Ohlson, Carl TI Mental Skills Training With Basic Combat Training Soldiers: A Group-Randomized Trial SO JOURNAL OF APPLIED PSYCHOLOGY LA English DT Article DE cognitive training; sport psychology; performance; basic combat training; soldiers ID PSYCHOLOGICAL SKILLS; EMOTION REGULATION; SPORT PERFORMANCE; SELF-REGULATION; METAANALYSIS; STRATEGIES; ORGANIZATIONS; INTERVENTIONS; MOTIVATION; VARIANCE AB Cognitive skills training has been linked to greater skills, self-efficacy, and performance. Although research in a variety of organizational settings has demonstrated training efficacy, few studies have assessed cognitive skills training using rigorous, longitudinal, randomized trials with active controls. The present study examined cognitive skills training in a high-risk occupation by randomizing 48 platoons (N = 2,432 soldiers) in basic combat training to either (a) mental skills training or (b) an active comparison condition (military history). Surveys were conducted at baseline and 3 times across the 10-week course. Multilevel mixed-effects models revealed that soldiers in the mental skills training condition reported greater use of a range of cognitive skills and increased confidence relative to those in the control condition. Soldiers in the mental skills training condition also performed better on obstacle course events, rappelling, physical fitness, and initial weapons qualification scores, although effects were generally moderated by gender and previous experience. Overall, effects were small; however, given the rigor of the design, the findings clearly contribute to the broader literature by providing supporting evidence that cognitive training skills can enhance performance in occupational and sports settings. Future research should address gender and experience to determine the need for targeting such training appropriately. C1 [Adler, Amy B.; Bliese, Paul D.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Pickering, Michael A.; Hammermeister, Jon] Eastern Washington Univ, Coll Hlth Sci & Publ Hlth, Cheney, WA USA. [Williams, Jason] Res Triangle Inst, Res Triangle Pk, NC 27709 USA. [Harada, Coreen] Army Resiliency Directorate, Crystal City, VA USA. [Csoka, Louis] Apex Performance Inc, Charlotte, NC USA. [Holliday, Bernie] US Mil Acad, Army Ctr Enhanced Performance, West Point, NY USA. [Ohlson, Carl] US Mil Acad, Ctr Enhanced Performance, West Point, NY USA. RP Adler, AB (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM amy.b.adler.civ@mail.mil FU Army Center for Enhanced Performance part of the Army Resiliency Directorate FX The Army Center for Enhanced Performance, the original cosponsor of this research, has been restructured and is now part of the Army Resiliency Directorate. We thank study associates Antonio (Tony) Best, Ryan McCausland, William (Tony) Barnes II, Julie Merrill, Robert Klocko, Rachel Eckford, Victor Martinez, Angela Salvi, Steven Terry, and Joe Womble; Tom Powers of the University of South Carolina Sumter; Major General Bradley May, Sonya Cable, and Stephanie Muraca from the Training and Doctrine Command; Brigadier General (Retired) Rhonda Cornum; the military history instructors, performance enhancement specialists, and Basic Combat Training soldiers; Army Community Services; and Robert Bray, Marion (Becky) Lane, and the Research Triangle Institute. The views expressed in this article are those of the authors and do not necessarily represent the official policy or position of the U.S. Army Medical Command or the U.S. Army. NR 66 TC 2 Z9 2 U1 13 U2 38 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0021-9010 EI 1939-1854 J9 J APPL PSYCHOL JI J. Appl. Psychol. PD NOV PY 2015 VL 100 IS 6 BP 1752 EP 1764 DI 10.1037/apl0000021 PG 13 WC Psychology, Applied; Management SC Psychology; Business & Economics GA CV9DZ UT WOS:000364588900005 PM 26011718 ER PT J AU Mann-Salinas, EA Joyner, DD Guymon, CH Ward, CL Rathbone, CR Jones, JA Akers, KS AF Mann-Salinas, Elizabeth A. Joyner, Denar D. Guymon, Charles H. Ward, Catherine L. Rathbone, Christopher R. Jones, John A. Akers, Kevin S. TI Comparison of Decontamination Methods for Human Skin Grafts SO Journal of Burn Care & Research LA English DT Article ID POVIDONE-IODINE; CHLORHEXIDINE; METAANALYSIS; ANTISEPSIS; INFECTION; VIABILITY; SURGERY; TIME AB Skin grafts intended for autologous transplant may be dropped on the operating room floor during handling. The authors examined optimal procedures for decontaminating tissue intended for burn surgery. Porcine skin (5 x 5 cm sections) harvested from expired animals using standard procedures was inoculated with either 10(6) CFU/ml Staphylococcus aureus or Klebsiella pneumoniae. Decontaminating strategies were compared: 10% povidone iodine, 0.04% chlorhexidine, or 50 U/ml bacitracin for injection, and mechanical agitation using normal saline or sterile water; each agent was applied for 60 seconds. Each skin section was blended and plated on agar for bacterial enumeration using the spread plate method. Tissue viability was evaluated in parallel using a cell viability reagent, along with a control (heat at 200 degrees C for 5 min). Bacterial counts were log transformed; one-way ANOVA with Tukey-Kramer HSD analysis were performed. Concentration of organisms <10(5) CFU/g was considered clinically insignificant colonization. Eight donors provided 21 S. aureus and six K. pneumoniae samples. After exposure, mean organism concentration (CFU/g) was <10(5) for povidone iodine (S. aureus 2.83 x 10(4); K. pneumoniae 1.85 x 10(4)), chlorhexidine (S. aureus 4.52 x 10(4); K. pneumoniae 1.77 x 10(4)), and normal saline (K. pneumoniae 8.76 x 10(4)) treated groups. After log transform, only povidone iodine and chlorhexidine were found to be different from control in both groups. Viability was decreased in the positive control group, but not in treatment groups. Agents routinely used for surgical skin prep (povidone iodine and chlorhexidine), reduced both Gram-positive and Gram-negative contamination in tissue intended for skin grafting procedures. Antiseptic treatments did not impair the cellular viability of porcine skin. C1 [Mann-Salinas, Elizabeth A.; Joyner, Denar D.; Guymon, Charles H.; Ward, Catherine L.; Rathbone, Christopher R.; Jones, John A.; Akers, Kevin S.] US Army Inst Surg Res, San Antonio, TX 78234 USA. RP Mann-Salinas, EA (reprint author), US Army Inst Surg Res, San Antonio, TX 78234 USA. NR 15 TC 0 Z9 0 U1 2 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1559-047X EI 1559-0488 J9 J BURN CARE RES JI J. Burn Care Res. PD NOV-DEC PY 2015 VL 36 IS 6 BP 636 EP 640 DI 10.1097/BCR.0000000000000188 PG 5 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA CV5UZ UT WOS:000364338000009 PM 25383978 ER PT J AU Costanzo, MR Negoianu, D Jaski, BE Bart, BA Heywood, JT Anand, IS Smelser, J Kaneshige, AM Chomsky, DB Adler, ED Haas, GJ Watts, JA Nabut, JL Schollmeyer, MP Fonarow, GC AF Costanzo, M. R. Negoianu, D. Jaski, B. E. Bart, B. A. Heywood, J. T. Anand, I. S. Smelser, J. Kaneshige, A. M. Chomsky, D. B. Adler, E. D. Haas, G. J. Watts, J. A. Nabut, J. L. Schollmeyer, M. P. Fonarow, G. C. TI Aquapheresis Versus Intravenous Diuretics and Hospitalizations for Heart Failure (AVOID-HF) Trial SO JOURNAL OF CARDIAC FAILURE LA English DT Meeting Abstract CT 19th Annual Scientific Meeting of the Heart-Failure-Society-of-America CY SEP 26-29, 2015 CL Washington, DC SP Heart Failure Soc Amer C1 [Costanzo, M. R.] Advocate Heart Inst, Naperville, IL USA. [Negoianu, D.] Univ Penn, Med Ctr, Div Nephrol, Philadelphia, PA 19104 USA. [Jaski, B. E.] Sharp Mem Hosp & Rehabil Ctr, San Diego Cardiac Ctr, San Diego, CA USA. [Bart, B. A.] Hennepin Cty Med Ctr, Dept Med, Div Cardiol, Minneapolis, MN 55415 USA. [Heywood, J. T.] Scripps Clin, Heart Failure Recovery & Res Program, San Diego, CA USA. [Anand, I. S.] Univ Minnesota VA Med Ctr, Minneapolis, MN USA. [Smelser, J.] Huntsville Renal Clin, Huntsville, AL USA. [Kaneshige, A. M.] Oklahoma Heart Inst, Tulsa, OK USA. [Chomsky, D. B.] St Thomas Heart Hosp, Nashville, TN USA. [Adler, E. D.] Univ Calif San Diego, Div Cardiol, San Diego, CA 92103 USA. [Haas, G. J.] Ohio State Univ, Div Cardiol, Columbus, OH 43210 USA. [Watts, J. A.] Brooke Army Med Ctr, San Antonio, TX USA. [Nabut, J. L.; Schollmeyer, M. P.] Baxter Healthcare Corp, Deerfield, IL USA. [Fonarow, G. C.] Univ Calif Los Angeles, Div Cardiol, Los Angeles, CA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS PI PHILADELPHIA PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA SN 1071-9164 EI 1532-8414 J9 J CARD FAIL JI J. Card. Fail. PD NOV PY 2015 VL 21 IS 11 BP 937 EP 939 PG 3 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA CV9JK UT WOS:000364603300018 ER PT J AU Quartana, PJ Finan, PH Smith, MT AF Quartana, Phillip J. Finan, Patrick H. Smith, Michael T. TI Evidence for Sustained Mechanical Pain Sensitization in Women With Chronic Temporomandibular Disorder Versus Healthy Female Participants SO JOURNAL OF PAIN LA English DT Article DE Temporomandibular disorder; pain; chronic pain; sensitization; pain threshold; mechanical pain ID EXPERIMENTALLY EVOKED PAIN; TEMPORAL SUMMATION; CLINICAL-RELEVANCE; MYOFASCIAL PAIN; JOINT DISORDER; MUSCLE PAIN; SENSITIVITY; TMD; HYPERALGESIA; ASSOCIATION AB Generalized dysfunction of the nociceptive system has been hypothesized to be an important pathophysiologic process underlying temporomandibular disorder (TMD) pain. Studies have not identified sensitization to painful stimuli administered prospectively across consecutive days among participants with TMD with chronic pain. We attempted to isolate an empirically derived laboratory-based marker of sustained mechanical pain sensitization. We examined whether this index accounted for variance in prospective assessments of clinical TMD pain. Participants were women with a clinical diagnosis of chronic TMD (n = 30) and healthy female controls (n = 30). Pain thresholds were assessed using digital algometry 4 times at 12-hour intervals over 48 consecutive hours and clinical TMD pain via follow-up telephone assessments. Sustained mechanical pain sensitization, defined by statistically significant linear decrements in pressure pain thresholds across the consecutive testing sessions, discriminated chronic TMD and control participants. An index of sustained sensitization at the masseter accounted for unique variance in clinical TMD pain over the subsequent 3-month assessment period, even controlling for mean pain threshold and baseline pain severity. These preliminary findings highlight discriminant and predictive validity characteristics of a novel marker of protracted pain sensitization among women with chronic TMD pain. Perspective: A laboratory-based and empirically defined marker of sustained mechanical pain sensitization over the course of days with acceptable discriminant and predictive validity was identified. This marker may represent a clinically useful marker of chronic TMD pain in women. Published by Elsevier Inc. on behalf of the American Pain Society C1 [Quartana, Phillip J.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Finan, Patrick H.; Smith, Michael T.] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA. RP Quartana, PJ (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM phillip.j.quartana2.civ@mail.mil FU NIH [NS047168, AR054871, T32MH075884]; National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH) [UL1 RR 025005]; NIH Roadmap for Medical Research FX This work was supported by NIH grants NS047168, AR054871, and T32MH075884 and by grant number UL1 RR 025005 from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH), and NIH Roadmap for Medical Research. Its contents are solely the responsibility of the authors and do not necessarily represent the official view of NCRR or NIH. Information on NCRR is available at http://www.ncrr.nih.gov/. Information on re-engineering the clinical research enterprise can be obtained from http://nihroadmap.nih.gov/clinicalresearch/overview-translational.asp. M.T.S. holds an equity stake in BMED Technologies, which is managed by the Johns Hopkins Office on Conflict of Interest. There are no additional conflicts of interest to report. NR 42 TC 0 Z9 0 U1 3 U2 11 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1526-5900 J9 J PAIN JI J. Pain PD NOV PY 2015 VL 16 IS 11 BP 1127 EP 1135 DI 10.1016/j.jpain.2015.08.002 PG 9 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA CV9MX UT WOS:000364612400007 PM 26281948 ER PT J AU Bornemann, P Johnson, J Tiglao, S Moghul, A Swain, S Bornemann, G Lustik, M AF Bornemann, Paul Johnson, Jeremy Tiglao, Samuel Moghul, Amina Swain, Sheila Bornemann, Gina Lustik, Mike TI Assessment of Primary Care Physicians' Use of a Pocket Ultrasound Device (TM) to Measure Left Ventricular Mass in Patients with Hypertension SO JOURNAL OF THE AMERICAN BOARD OF FAMILY MEDICINE LA English DT Article DE Left Ventricular Hypertrophy; Ultrasonography ID HYPERTROPHY; ECHOCARDIOGRAPHY; COMMITTEE; RISK AB Purpose: Left ventricular hypertrophy (LVH) is common in primary care and is associated with increased morbidity and mortality. Treatment of underlying hypertension can reverse LVH and eliminate the associated risks. Electrocardiography is widely available and commonly used to screen hypertensive patients for LVH, but it is limited by low sensitivity. Limited echocardiographic measurement of the left ventricle is a method for screening with improved sensitivity; however, it is not currently widely used in the primary care setting. This study attempts to test the accuracy of primary care physicians' (PCPs) measurements of the left ventricle using a pocket-sized ultrasound (pUS) device after a brief training session. Methods: This study was performed in an outpatient cardiology clinic by 3 family medicine residents and 1 family medicine faculty member after a 4-hour training session. Measurements of the left ventricle were made by PCPs using a pUS device; these measurements were compared with cardiologists' measurements from images obtained by echocardiography technicians. Left ventricular mass index (LVMI) was calculated based on these measurements and then compared between groups. Results: There was no statistically significant difference between the mean LVMI calculations in the 2 groups. The agreement in measurements between the groups, however, showed high variability. This was manifested by the low sensitivity (70%) and specificity (76%) of PCPs in the detection of LVH. Conclusions: This study showed that limited echocardiography for the detection of LVH performed by PCPs at the point of care was feasible. Future studies are needed to determine the ideal training and experience necessary to yield competency. C1 [Bornemann, Paul] Univ S Carolina, Dept Family & Preventat Med, Columbia, SC 29203 USA. [Johnson, Jeremy; Tiglao, Samuel; Moghul, Amina; Swain, Sheila; Bornemann, Gina; Lustik, Mike] Tripler Army Med Ctr, Dept Family Med, Honolulu, HI 96859 USA. RP Bornemann, P (reprint author), Univ S Carolina, Dept Family & Preventat Med, 3209 Colonial Dr, Columbia, SC 29203 USA. EM paul.bornemann@uscmed.sc.edu NR 14 TC 1 Z9 1 U1 0 U2 1 PU AMER BOARD FAMILY MEDICINE PI LEXINGTON PA 2228 YOUNG DR, LEXINGTON, KY 40505 USA SN 1557-2625 EI 1558-7118 J9 J AM BOARD FAM MED JI J. Am. Board Fam. Med. PD NOV-DEC PY 2015 VL 28 IS 6 BP 706 EP 712 DI 10.3122/jabfm.2015.06.140314 PG 7 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA CW3CK UT WOS:000364869400005 PM 26546645 ER PT J AU Burgess, E AF Burgess, Edwin TI Operation Thunderbolt: Flight 139 and the Raid on Entebbe Airport, the Most Audacious Hostage Rescue SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin] US Army Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. RP Burgess, E (reprint author), US Army Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD NOV 1 PY 2015 VL 140 IS 18 BP 96 EP 97 PG 2 WC Information Science & Library Science SC Information Science & Library Science GA CV2UW UT WOS:000364113700167 ER PT J AU Mitchell, TA Wallum, TE White, CE Sanders, KE Aden, JK Bailey, JA Blackbourne, LH Murray, CK AF Mitchell, Thomas A. Wallum, Timothy E. White, Christopher E. Sanders, Kelly E. Aden, James K. Bailey, Jeffrey A. Blackbourne, Lorne H. Murray, Clinton K. TI Evaluation of the Effectiveness of the 2008 Postsplenectomy Vaccination Joint Theater Trauma System Clinical Practice Guideline SO MILITARY MEDICINE LA English DT Article ID PNEUMOCOCCAL POLYSACCHARIDE VACCINE; SPLENECTOMY; MANAGEMENT; RESPONSES AB Objectives: Postsplenectomy vaccination (PSV) in an austere environment to minimize overwhelming postsplenectomy infection is challenging. We evaluated the clinical impact of a March 2008 clinical practice guideline (CPG) dictating immediate PSV at North American Treaty Organization Role 3 medical treatment facilities and subsequent complications. Methods: Utilizing U.S. military medical databases, we characterized all U.S. patients with a splenic injury from November 2002 to January 2012 by their surgical management: laparotomy with splenectomy (LWS), laparotomy without splenectomy, or nonoperative management. Relevant data including demographics, vaccinations, and documented bacterial and fungal isolates were obtained. Results: LWS comprised 63.6% of the 409 patients with a splenic injury from 2002 to 2012. The implementation of the PSV CPG improved overall vaccination compliance from 48.9% pre-PSV CPG to 86.9% post-PSV CPG (p < 0.01). It was found that 1.3% (2/159) of completely vaccinated LWS patients compared with 0% (0/101) of the incompletely vaccinated LWS patients had Streptococcus pneumoniae isolates in 391.0 and 251.4 follow-up years, respectively (p = 0.52). No Neisseria meningitidis or Haemophilus influenzae isolates were identified. Conclusions: PSV CPG implementation improved theater vaccination without increasing the incidence of encapsulated organisms. C1 [Mitchell, Thomas A.; White, Christopher E.; Sanders, Kelly E.; Blackbourne, Lorne H.] San Antonio Mil Med Ctr, Dept Gen Surg, Jbsa Ft Sam Houston, TX 78234 USA. [Wallum, Timothy E.; Aden, James K.; Bailey, Jeffrey A.] US Army, Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA. [Murray, Clinton K.] San Antonio Mil Med Ctr, Dept Infect Dis, Jbsa Ft Sam Houston, TX 78234 USA. RP Mitchell, TA (reprint author), San Antonio Mil Med Ctr, Dept Gen Surg, 3551 Roger Brooke Dr, Jbsa Ft Sam Houston, TX 78234 USA. FU U.S. Military FX We acknowledge the Department of Defense Trauma Registry (DoDTR) and the Patient Administration Systems and Biostatistics Activity (PASBA) for providing data for this study. We would like to disclose that no external funds were used to finance this project, and the U.S. Military was solely responsible for funding this research. NR 13 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD NOV PY 2015 VL 180 IS 11 BP 1170 EP 1177 DI 10.7205/MILMED-D-14-00295 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA CV9UT UT WOS:000364633400015 PM 26540709 ER PT J AU DeGroot, DW Kenefick, RW Sawka, MN AF DeGroot, David W. Kenefick, Robert W. Sawka, Michael N. TI Impact of Arm Immersion Cooling During Ranger Training on Exertional Heat Illness and Treatment Costs SO MILITARY MEDICINE LA English DT Article ID PHYSIOLOGICAL STRAIN; STRESS; SOLDIERS; DEATHS; WATER; WORK AB Ranger training includes strenuous physical activities and despite heat mitigations strategies, numerous cases of serious exertional heat illness (EHI) occur. We developed an Arm Immersion Cooling (AIC) system that is not logistically burdensome and may be easily employed in training environments. Purpose: To examine the effect of AIC on EHI incidence, severity, and treatment costs during Ranger School. Methods: The training program was standardized for physical exertion and heat stress factors throughout the study period. AIC was employed summer months of 2010-2012 (n = 3,930 Soldiers) and Control (CON; n = 6,650 Soldiers) data were obtained for summer months of 2007-2009. Descriptive characteristics of all EHI casualties were obtained, including hospitalization status (treated and released [Treat], evacuated [Evac] or admitted [Admit] to the hospital), which served as proxy indicator of illness/injury severity. Medical cost savings were calculated from hospital records. Results: Incidence rates were not different (CON 4.06 vs. AIC 4.00/1,000 person-days). Treat increased during AIC (18.43 vs. 4.84/1,000 person-days) accompanied by marked but non-significant decreases in Evac and Admit rates. AIC use was associated with a medical cost savings of $1,719 per casualty. Conclusions: AIC implementation during strenuous physical training in summer months can reduce EHI severity and associated medical treatment costs. C1 [DeGroot, David W.] US Army, Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. [Kenefick, Robert W.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. [Sawka, Michael N.] Georgia Inst Technol, Atlanta, GA 30332 USA. RP DeGroot, DW (reprint author), US Army, Publ Hlth Command, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. FU Brigade S-3 Office FX The authors thank the Ranger Training Brigade Physician Assistants and Brigade S-3 Office for their support throughout the duration of this project. The statistical assistance of Ms. Karen Deaver and Mr. Shane Hall is greatly appreciated. NR 23 TC 1 Z9 1 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD NOV PY 2015 VL 180 IS 11 BP 1178 EP 1183 DI 10.7205/MILMED-D-14-00727 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA CV9UT UT WOS:000364633400016 PM 26540710 ER PT J AU Hawk, A AF Hawk, Alan TI Virtual Anatomy-1900 SO MILITARY MEDICINE LA English DT Editorial Material C1 US Army, Med Res & Mat Command, Natl Museum Hlth & Med, Silver Spring, MD 20910 USA. RP Hawk, A (reprint author), US Army, Med Res & Mat Command, Natl Museum Hlth & Med, 2500 Linden Lane, Silver Spring, MD 20910 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD NOV PY 2015 VL 180 IS 11 BP 1199 EP 1200 DI 10.7205/MILMED-D-15-00394 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA CV9UT UT WOS:000364633400020 PM 26540714 ER PT J AU Hsu, AL Herring, PK Gabor, NM Ha, S Shin, YC Song, Y Chin, M Dubey, M Chandrakasan, AP Kong, J Jarillo-Herrero, P Palacios, T AF Hsu, Allen L. Herring, Patrick K. Gabor, Nathaniel M. Ha, Sungjae Shin, Yong Cheol Song, Yi Chin, Matthew Dubey, Madan Chandrakasan, Anantha P. Kong, Jing Jarillo-Herrero, Pablo Palacios, Tomas TI Graphene-Based Thermopile for Thermal Imaging Applications SO NANO LETTERS LA English DT Article DE Graphene; thermal imaging; infrared; detectors; thermopile; microelectromechanical Systems ID PLASMONICS; TERAHERTZ; PHOTORESPONSE; PHOTODETECTOR; CONDUCTIVITY; ARRAY AB In this work, we leverage graphene's unique tunable Seebeck coefficient for the demonstration of a graphene-based thermal imaging system. By integrating graphene based photothermo-electric detectors with micromachined silicon nitride membranes, we are able to achieve room temperature responsivities on the order of similar to 7-9 V/W (at lambda = 10.6 mu m), with a time constant of similar to 23 ms. The large responsivities, due to the combination of thermal isolation and broadband infrared absorption from the underlying SiN membrane, have enabled detection as well as stand-off imaging of an incoherent blackbody target (300-500 K). By comparing the fundamental achievable performance of these graphene-based thermopiles with standard thermocouple materials, we extrapolate that graphene's high carrier mobility can enable improved performances with respect to two main figures of merit for infrared detectors: detectivity (>8 X 10(8) cm Hz(1/2)W(-1)) and noise equivalent temperature difference (<100 mK). Furthermore, even average graphene carrier mobility (<1000 cm(2) V-1 s(-1)) is still sufficient to detect the emitted thermal radiation from a human target. C1 [Hsu, Allen L.; Ha, Sungjae; Song, Yi; Chandrakasan, Anantha P.; Kong, Jing; Palacios, Tomas] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA. [Herring, Patrick K.; Jarillo-Herrero, Pablo] MIT, Dept Phys, Cambridge, MA 02139 USA. [Shin, Yong Cheol] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA. [Herring, Patrick K.] Harvard Univ, Dept Phys, Cambridge, MA 02138 USA. [Gabor, Nathaniel M.] Univ Calif Riverside, Dept Phys & Astron, Riverside, CA 92521 USA. [Chin, Matthew; Dubey, Madan] Army Res Lab, Adelphi, MD 20783 USA. RP Jarillo-Herrero, P (reprint author), MIT, Dept Phys, Cambridge, MA 02139 USA. EM pjarillo@mit.edu; tpalacios@mit.edu FU MIT/Army Institute for Soldier Nanotechnologies; Army Research Laboratories; Office of Naval Research GATE-MURI program; Solid State Solar Energy Conversion Center (S3TEC); MIT Center for Integrated Circuits and Systems; Air Force Office of Scientific Research; STC Center for Integrated Quantum Materials, NSF [DMR-1231319] FX This work has been supported in part by MIT/Army Institute for Soldier Nanotechnologies, Army Research Laboratories, Office of Naval Research GATE-MURI program, Solid State Solar Energy Conversion Center (S3TEC), MIT Center for Integrated Circuits and Systems, and Air Force Office of Scientific Research. Sample fabrication was performed at the MIT Microsystems Technology Laboratories and NanoStructure Laboratories in the Research Lab of Electronics (NSL-RLE). J.K. also acknowledges the STC Center for Integrated Quantum Materials, NSF Grant No. DMR-1231319. NR 31 TC 5 Z9 5 U1 8 U2 59 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1530-6984 EI 1530-6992 J9 NANO LETT JI Nano Lett. PD NOV PY 2015 VL 15 IS 11 BP 7211 EP 7216 DI 10.1021/acs.nanolett.5b01755 PG 6 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA CW1BU UT WOS:000364725400007 PM 26468687 ER PT J AU Fan, XL Luo, C Lamb, JL Zhu, YJ Xu, K Wang, CS AF Fan, Xiulin Luo, Chao Lamb, Julia Zhu, Yujie Xu, Kang Wang, Chunsheng TI PEDOT Encapsulated FeOF Nanorod Cathodes for High Energy Lithium-Ion Batteries SO NANO LETTERS LA English DT Article DE Cathode material; conversion reaction; FeOF; PEDOT ID RECHARGEABLE LI BATTERIES; IRON FLUORIDE; FEO0.7F1.3/C NANOCOMPOSITE; ELECTRODE MATERIALS; METAL FLUORIDES; STORAGE; SPECTROSCOPY; CHALLENGES; CHEMISTRY; MECHANISM AB Conversion-reaction cathodes can potentially double the energy density of current Li-ion batteries. However, the poor cycling stability, low energy efficiency, and low power density of conversion-reaction cathodes limit their applications for Li-ion batteries. Herein, we report a revolutionary advance in a conversion-reaction cathode by developing a core-shell FeOF@PEDOT nanorods, in which partial substitution of fluorine with oxygen in FeF3 substantially enhance the reaction kinetics and reduce the potential hysteresis, while conformal nanolayer PEDOT coating provides a roubst fast electronic connection and prevents the side reactions. The FeOF@PEDOT nanorods deliver a capacity of 560 mA h g(-1) at 10 mA g(-1) with an energy density of >1100 W h kg(-1) which is more than two times higher than the theoretical energy density of LiCoO2. The FeOF@PEDOT nanorods can maintain a capacity of similar to 430 mA h g(-1) at 50 mA g(-1) (840 W h kg(-1)) for over 150 cycles with capacity decay rate of only 0.04% per cycle, which is 2 orders of magnitude lower than the capacity decay rate ever reported among all conversion-reaction cathodes. Detailed characterizations were conducted to identify the structure and mechanism responsible for these significant improvements that could translate into a Li-ion cell with a 2x increase in energy density. C1 [Fan, Xiulin; Luo, Chao; Lamb, Julia; Zhu, Yujie; Wang, Chunsheng] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. [Xu, Kang] US Army, Res Lab, Electrochem Branch, Power & Energy Div,Sensor & Electron Devices Dire, Adelphi, MD 20783 USA. RP Wang, CS (reprint author), Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. EM cswang@umd.edu RI Wang, Chunsheng/H-5767-2011 OI Wang, Chunsheng/0000-0002-8626-6381 FU Army Research Lab [W911NF1420031]; Maryland NanoCenter; NispLab FX This work was supported by Army Research Lab under Award number W911NF1420031. The authors gratefully acknowledge the support of the Maryland NanoCenter and its NispLab. NR 50 TC 9 Z9 9 U1 31 U2 138 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1530-6984 EI 1530-6992 J9 NANO LETT JI Nano Lett. PD NOV PY 2015 VL 15 IS 11 BP 7650 EP 7656 DI 10.1021/acs.nanolett.5b03601 PG 7 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA CW1BU UT WOS:000364725400072 PM 26451460 ER PT J AU Klacka, J Kocifaj, M Kundracik, F Videen, G Kohut, I AF Klacka, Jozef Kocifaj, Miroslav Kundracik, Frantisek Videen, Gorden Kohut, Igor TI Generalization of electromagnetic scattering by charged grains through incorporation of interband and intraband effects SO OPTICS LETTERS LA English DT Article ID OPTICAL-PROPERTIES; PARTICLES; WAVES AB Scattering of electromagnetic radiation by electrically charged spherical particles is treated theoretically. A generalization of the approach is performed by incorporating both intraband and interband effects, while a new oscillatory term corresponding to the classical dispersion theory and the semi-quantum approach is considered. It is shown through a set of numerical experiments that interband effects may reduce the amplitude of resonant peaks for scattering, Q(sca), and absorption, Q(abs), and cause a shift of peak positions to longer wavelengths. In general, the resonant features due to interband and intraband effects can occur at different frequencies; thus, both together may result in qualitatively and quantitatively new optical signatures of electrically charged particles. This is a motivating factor for experimentalists who can use the particles as targeted probes, for example, in mapping the electric fields in different media based on scattering and/or absorption properties of electrified particulate systems. (C) 2015 Optical Society of America C1 [Klacka, Jozef; Kocifaj, Miroslav; Kundracik, Frantisek] Comenius Univ, Fac Math Phys & Informat, Bratislava 84248, Slovakia. [Kocifaj, Miroslav] Slovak Acad Sci, ICA, Bratislava 84503, Slovakia. [Videen, Gorden] INTA, Madrid 28850, Spain. [Videen, Gorden] US Army Res Lab, AMSRD ARL CI ES, Adelphi, MD 20783 USA. [Kohut, Igor] Slovak Acad Sci, Inst Earth Sci, Bratislava 84005, Slovakia. RP Kocifaj, M (reprint author), Comenius Univ, Fac Math Phys & Informat, Bratislava 84248, Slovakia. EM Miroslav.Kocifaj@savba.sk FU U.S. Army Research Laboratory (ARL) [W911NF-14-1-0601]; Ministerstvo skolstva, vedy, vyskumu a sportu Slovenskej republiky (Ministry of Education, Science, Research and Sport of the Slovak Republic) [1/067/13, 2/0002/12] FX U.S. Army Research Laboratory (ARL) (W911NF-14-1-0601); Ministerstvo skolstva, vedy, vyskumu a sportu Slovenskej republiky (Ministry of Education, Science, Research and Sport of the Slovak Republic) (1/067/13, 2/0002/12). NR 23 TC 5 Z9 5 U1 3 U2 6 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 EI 1539-4794 J9 OPT LETT JI Opt. Lett. PD NOV 1 PY 2015 VL 40 IS 21 BP 5070 EP 5073 DI 10.1364/OL.40.005070 PG 4 WC Optics SC Optics GA CV7QH UT WOS:000364468600063 PM 26512521 ER PT J AU Lombardini, ED Gettayacamin, M Turner, GDH Brown, AE AF Lombardini, E. D. Gettayacamin, M. Turner, G. D. H. Brown, A. E. TI A Review of Plasmodium coatneyi-Macaque Models of Severe Malaria SO VETERINARY PATHOLOGY LA English DT Review DE Plasmodium coatneyi; malaria; macaque; pathophysiology; pathology; cerebral; severe; model ID HUMAN CEREBRAL MALARIA; FALCIPARUM-INFECTED ERYTHROCYTES; DISSEMINATED INTRAVASCULAR COAGULATION; SYMMETRICAL PERIPHERAL GANGRENE; RHESUS-MONKEYS; PRIMATE MODEL; PARASITIZED ERYTHROCYTES; KNOWLESI MALARIA; NONHUMAN PRIMATE; MACACA-MULATTA AB Malaria remains one of the most significant public health concerns in the world today. Approximately half the human population is at risk for infection, with children and pregnant women being most vulnerable. More than 90% of the total human malaria burden, which numbers in excess of 200 million annually, is due to Plasmodium falciparum. Lack of an effective vaccine and a dwindling stockpile of antimalarial drugs due to increased plasmodial resistance underscore the critical need for valid animal models. Plasmodium coatneyi was described in Southeast Asia 50 years ago. This plasmodium of nonhuman primates has been used sporadically as a model for severe malaria, as it mimics many of the pathophysiologic features of human disease. This review covers the reported macroscopic, microscopic, ultrastructural, and molecular pathology of P. coatneyi infection in macaques, specifically focusing on the rhesus macaque, as well as describing the critical needs still outstanding in the validation of this crucial model of human disease. C1 [Lombardini, E. D.; Gettayacamin, M.] Armed Forces Res Inst Med Sci, Dept Vet Med, Bangkok 10400, Thailand. [Turner, G. D. H.] Mahidol Univ, Fac Trop Med, Mahidol Oxford Clin Res Unit, Bangkok, Thailand. [Turner, G. D. H.] Univ Oxford, Ctr Trop Med, Nuffield Dept Med, Oxford, England. [Brown, A. E.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Lombardini, ED (reprint author), Armed Forces Res Inst Med Sci, Dept Vet Med, Bangkok 10400, Thailand. EM Lombardinied@afrims.org FU Wellcome Trust of Great Britain [089275/Z/09/Z] FX We would like to state our sincere appreciation to the generation of researchers and scientists who have labored toward a greater understanding of Plasmodium coatneyi malaria, to the staff of the Department of Veterinary Medicine of AFRIMS, and to constructive discussions and advice of Professor Nick White, Mahidol Oxford Tropical Medicine Research Unit and University of Oxford, and grant support from the Wellcome Trust of Great Britain (grant 089275/Z/09/Z). NR 125 TC 1 Z9 1 U1 3 U2 7 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0300-9858 EI 1544-2217 J9 VET PATHOL JI Vet. Pathol. PD NOV PY 2015 VL 52 IS 6 BP 998 EP 1011 DI 10.1177/0300985815583098 PG 14 WC Pathology; Veterinary Sciences SC Pathology; Veterinary Sciences GA CW1FF UT WOS:000364734300002 PM 26077782 ER PT J AU van Helmond, N Johnson, BD Curry, TB Cap, AP Convertino, VA Joyner, MJ AF van Helmond, Noud Johnson, Blair D. Curry, Timothy B. Cap, Andrew P. Convertino, Victor A. Joyner, Michael J. TI Coagulation changes during lower body negative pressure and blood loss in humans SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY LA English DT Article DE blood coagulation; hemorrhage; lower body negative pressure; blood coagulation tests; humans; central hypovolemia ID CENTRAL VENOUS-PRESSURE; COMBAT CASUALTY CARE; PLASMA-VOLUME; HEMORRHAGIC-SHOCK; UPRIGHT POSTURE; RESPONSES; MODEL; MEN; THROMBELASTOGRAPHY; AGGREGATION AB We tested the hypothesis that markers of coagulation activation are greater during lower body negative pressure (LBNP) than those obtained during blood loss (BL). We assessed coagulation using both standard clinical tests and thrombelastography (TEG) in 12 men who performed a LBNP and BL protocol in a randomized order. LBNP consisted of 5-min stages at 0, -15, -30, and -45 mmHg of suction. BL included 5 min at baseline and following three stages of 333 ml of blood removal (up to 1,000 ml total). Arterial blood draws were performed at baseline and after the last stage of each protocol. We found that LBNP to -45 mmHg is a greater central hypovolemic stimulus versus BL; therefore, the coagulation markers were plotted against central venous pressure (CVP) to obtain stimulus-response relationships using the linear regression line slopes for both protocols. Paired t-tests were used to determine whether the slopes of these regression lines fell on similar trajectories for each protocol. Mean regression line slopes for coagulation markers versus CVP fell on similar trajectories during both protocols, except for TEG alpha degrees angle (-0.42 +/- 0.96 during LBNP vs. -2.41 +/- 1.13 degrees/mmHg during BL; P < 0.05). During both LBNP and BL, coagulation was accelerated as evidenced by shortened R-times (LBNP, 9.9 +/- 2.4 to 6.2 +/- 1.1; BL, 8.7 +/- 1.3 to 6.4 +/- 0.4 min; both P < 0.05). Our results indicate that LBNP models the general changes in coagulation markers observed during BL. C1 [van Helmond, Noud; Johnson, Blair D.; Curry, Timothy B.; Joyner, Michael J.] Mayo Clin, Dept Anesthesiol, Rochester, MN USA. [van Helmond, Noud] Radboud Univ Nijmegen, Dept Physiol, Med Ctr, NL-6525 ED Nijmegen, Netherlands. [Johnson, Blair D.] SUNY Buffalo, Dept Exercise & Nutr Sci, Buffalo, NY 14260 USA. [Cap, Andrew P.; Convertino, Victor A.] US Army, Inst Surg Res, Ft Sam Houston, TX USA. RP Johnson, BD (reprint author), 208A Kimball Tower, Buffalo, NY 14214 USA. EM blairjoh@buffalo.edu FU U.S. Army MRMC Combat Casualty Care Research Program Grant [W81XWH-11-1-0823]; American Heart Association Midwest Affiliate Grant [13POST-14380027]; Dutch Heart Foundation E. Dekker Stipend [2012SB013] FX Support for this study was provided by U.S. Army MRMC Combat Casualty Care Research Program Grant W81XWH-11-1-0823, American Heart Association Midwest Affiliate Grant 13POST-14380027 (to B. D. Johnson), and by Dutch Heart Foundation E. Dekker Stipend 2012SB013 (to N. V. Helmond). NR 39 TC 2 Z9 2 U1 1 U2 3 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0363-6135 EI 1522-1539 J9 AM J PHYSIOL-HEART C JI Am. J. Physiol.-Heart Circul. Physiol. PD NOV 1 PY 2015 VL 309 IS 9 BP H1591 EP H1597 DI 10.1152/ajpheart.00435.2015 PG 7 WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular Disease SC Cardiovascular System & Cardiology; Physiology GA CV2NH UT WOS:000364092900019 PM 26371166 ER PT J AU Hauret, KG Bedno, S Loringer, K Kao, TC Mallon, T Jones, BH AF Hauret, Keith G. Bedno, Sheryl Loringer, Kelly Kao, Tzu-Cheg Mallon, Timothy Jones, Bruce H. TI Epidemiology of Exercise- and Sports-Related Injuries in a Population of Young, Physically Active Adults: A Survey of Military Servicemembers SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE sports; running; exercise; injury; military training ID TRAINING-RELATED INJURIES; PUBLIC-HEALTH; MUSCULOSKELETAL INJURY; ICE HOCKEY; AIR-FORCE; PREVENTION; RISK; RECOMMENDATIONS; ASSOCIATION; RECREATION AB Background: Numerous studies document the health benefits of a physically active lifestyle, but relatively few document the hazards of physical activity. Because of the requirement for physical fitness to complete their mission, the United States military services have a vested interest in understanding the benefits and risks of physical activity including exercise and sports. One of these risks is injury. Rates and proportion of injuries caused by exercise- and sports-related (ESR) activities have not been reported previously across the services. Purpose: The purposes of this population survey were to (1) document the rates and proportion of all injuries caused by ESR activities among military personnel, (2) compare rates across the military services, and (3) describe the causes and types of ESR injuries as well as associated days of limited activity. Study Design: Descriptive epidemiology study. Methods: The Defense Manpower Data Center administered the web-based 2008 Status of Forces Survey of Active Duty Service Members to a random sample of active-duty personnel. In all, 10,692 servicemembers completed the survey, which included questions about injuries from any cause and from exercise and sports during the previous year. Responses were weighted to produce population estimates for injury rates (any injury and ESR injury). Percentage distributions were used to describe activities, injury types, days of limited activity, and contributing factors for ESR injuries. Results: There were 49% of servicemembers who sustained an injury from any cause in the previous year; 25% had an ESR injury. Thus, 52% of all injuries were ESR injuries. ESR injury rates ranged from 20% for the Navy to 33% for the Marine Corps. Running accounted for 45% of ESR injuries. Forty percent of ESR injuries were sprains and strains. As an indicator of injury severity, 35% of ESR injuries required more than 2 weeks of limited activity. Conclusion: This study quantified the overall incidence of injuries and the large proportion that are caused by exercise and sports among military personnel, a population of healthy, physically active adults. Prevention strategies should focus on running, weight training, basketball, and football. Recommendations include adherence to evidence-based practices to reduce the occurrence of ESR injuries. C1 [Hauret, Keith G.; Loringer, Kelly; Jones, Bruce H.] US Army, Army Inst Publ Hlth, Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. [Bedno, Sheryl] Womack Army Med Ctr, Dept Prevent Med, Ft Bragg, NC USA. [Kao, Tzu-Cheg; Mallon, Timothy] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. RP Hauret, KG (reprint author), US Army, Army Inst Publ Hlth, Publ Hlth Command, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM keith.g.hauret.civ@mail.mil FU Uniformed Services University of the Health Sciences [C0874F] FX One or more of the authors has declared the following potential conflict of interest or source of funding: S.B. (fellow), T.M. (faculty), and T.-C.K. (faculty) were affiliated with the Uniformed Services University of the Health Sciences, which provided an intramural starter grant (#C0874F) of $2000, used to purchase a laptop for data storage that was secure, CAC enabled, and encrypted. NR 51 TC 2 Z9 2 U1 3 U2 15 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 EI 1552-3365 J9 AM J SPORT MED JI Am. J. Sports Med. PD NOV PY 2015 VL 43 IS 11 BP 2645 EP 2653 DI 10.1177/0363546515601990 PG 9 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA CV3XF UT WOS:000364199100004 PM 26378031 ER PT J AU Batchinsky, AI Chung, KK Cancio, LC AF Batchinsky, Andriy I. Chung, Kevin K. Cancio, Leopoldo C. TI Response to the Letter to the Editor by Payman Salamati MD and Rasoul Aliannejad MD SO BURNS LA English DT Letter ID RESPIRATORY-DISTRESS-SYNDROME; SMOKE-INHALATION INJURY; FIBEROPTIC BRONCHOSCOPY; VIRTUAL BRONCHOSCOPY; VENTILATION; MANAGEMENT; GAS C1 [Batchinsky, Andriy I.; Chung, Kevin K.; Cancio, Leopoldo C.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA. [Batchinsky, Andriy I.] Geneva Fdn, Tacoma, WA USA. RP Batchinsky, AI (reprint author), US Army Inst Surg Res, Multiorgan Support & Preservat Task Area, Battlefield Hlth & Trauma Res Inst, DTRD,DECS,NAMRU SA, BHT2 Bldg 3610,3650 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA. EM andriy.i.batchinsky.vol@mail.mil NR 12 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 EI 1879-1409 J9 BURNS JI Burns PD NOV PY 2015 VL 41 IS 7 BP 1615 EP 1616 DI 10.1016/j.burns.2015.08.031 PG 2 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA CV4PH UT WOS:000364248500034 PM 26382828 ER PT J AU Hartman, LJ Heinrich, ML Zovanyi, AM Ingram, MF Hobson, JP Kulesh, DA Craw, PD Jaissle, JG Norwood, DA Minogue, TD AF Hartman, Laurie J. Heinrich, Megan L. Zovanyi, Ashley M. Ingram, Michael F. Hobson, J. Peyton Kulesh, David A. Craw, Philip D. Jaissle, James G. Norwood, David A. Minogue, Timothy D. TI Demonstration of the Pre-Emergency Use Authorization Path Using 3 Minor Groove Binder-Hydrolysis Probe Assays to Detect Escherichia coli O104:H4 SO CLINICAL CHEMISTRY LA English DT Article ID MOLECULAR-PATHOLOGY; TESTS AB BACKGROUND: The Department of Defense (DoD) and the Food and Drug Administration (FDA) have collaboratively worked on a pre-Emergency Use Authorization (pre-EUA) process for in vitro diagnostic (IVD) devices, using FDA's regulatory flexibilities under the EUA authorities. The pre-EUA process enables FDA review of data in anticipation of a request for an EUA, advancing US government public health emergency preparedness efforts. METHODS: The IVD device developed to detect Escherichia coli O104:H4, for which an EUA has not been issued, serves as an example to illustrate that process. Specifically, DoD designed real-time PCR assays to target the virulent E. coli strain O104:H4 (etiological agent of the 2011 German outbreak) including: fliC (flagellin), Agg3C (AAF), and rfb (wbwC) on the basis of the published sequences. RESULTS: After development and optimization of these 3 specific assays, a defined protocol was followed to determine and document the sensitivity and specificity of each assay analytically. CONCLUSIONS: FDA reviewed these data and returned commentary on additional required experiments to complete the pre-EUA process and expedite the use of the device should there be an emergency need for an IVD device to detect this virulent E. coli strain before such a test is cleared by FDA. (C) 2015 American Association for Clinical Chemistry C1 [Hartman, Laurie J.; Heinrich, Megan L.; Zovanyi, Ashley M.; Ingram, Michael F.; Kulesh, David A.; Craw, Philip D.; Jaissle, James G.; Norwood, David A.; Minogue, Timothy D.] US Army Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD USA. [Hartman, Laurie J.] Clin RM, Hinckley, OH USA. [Hobson, J. Peyton] Food & Drug Adm, Silver Spring, MD USA. RP Minogue, TD (reprint author), 1425 Porter St, Frederick, MD 21702 USA. EM timothy.d.minogue.civ@mail.mil NR 13 TC 0 Z9 0 U1 1 U2 2 PU AMER ASSOC CLINICAL CHEMISTRY PI WASHINGTON PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA SN 0009-9147 EI 1530-8561 J9 CLIN CHEM JI Clin. Chem. PD NOV PY 2015 VL 61 IS 11 BP 1391 EP 1398 DI 10.1373/clinchem.2015.242750 PG 8 WC Medical Laboratory Technology SC Medical Laboratory Technology GA CV2UH UT WOS:000364112200012 PM 26384353 ER PT J AU Adams, BL Hurley, MM Jahnke, JP Stratis-Cullum, DN AF Adams, Bryn L. Hurley, Margaret M. Jahnke, Justin P. Stratis-Cullum, Dimitra N. TI Functional and Selective Bacterial Interfaces Using Cross-Scaffold Gold Binding Peptides SO JOM LA English DT Article ID PHAGE DISPLAY; IMPEDANCE MEASUREMENT; ENGINEERED PEPTIDES; ESCHERICHIA-COLI; SURFACE DISPLAY; METAL; NANOPARTICLES; ADSORPTION; IDENTIFICATION; SPECIFICITY AB We investigated the functional and selective activity of three phage-derived gold-binding peptides on the Escherichia coli (E. coli) bacterial cell surface display scaffold (eCPX) for the first time. Gold-binding peptides, p3-Au12 (LKAHLPPSRLPS), p8#9 (VSGSSPDS), and Midas-2 (TGTSVLIATPYV), were compared side-by-side through experiment and simulation. All exhibited strong binding to an evaporated gold film, with approximately a 4-log difference in binding between each peptide and the control sample. The increased affinity for gold was also confirmed by direct visualization of samples using Scanning Electron Microscopy (SEM). Peptide dynamics in solution were performed to analyze innate structure, and all three were found to have a high degree of flexibility. Preferential binding to gold over silicon for all three peptides was demonstrated, with up to four orders of magnitude selectivity exhibited by p3-Au12. The selectivity was also clearly evident through SEM analysis of the boundary between the gold film and silicon substrate. Functional activity of bound E. coli cells was further demonstrated by stimulating filamentation and all three peptides were characterized as prolific relative to control samples. This work shows great promise towards functional and active bacterial-hybrid gold surfaces and the potential to enable the next generation living material interfaces. C1 [Adams, Bryn L.; Hurley, Margaret M.; Jahnke, Justin P.; Stratis-Cullum, Dimitra N.] US Army, Res Lab, Adelphi, MD 20783 USA. RP Adams, BL (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA. EM dimitra.n.stratis-cullum.civ@mail.mil NR 83 TC 2 Z9 2 U1 6 U2 18 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1047-4838 EI 1543-1851 J9 JOM-US JI JOM PD NOV PY 2015 VL 67 IS 11 BP 2483 EP 2493 DI 10.1007/s11837-015-1662-7 PG 11 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing SC Materials Science; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing GA CV0JG UT WOS:000363936400003 ER PT J AU Wamsley, TV Coffier, ZA Brodie, K Dunkin, LM Raff, D Rosati, JD AF Wamsley, Ty V. Coffier, Zachary A. Brodie, Katherine Dunkin, Lauren M. Raff, David Rosati, Julie D. TI Guidance for Developing Coastal Vulnerability Metrics SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE Exposure; sensitivity; adaptive capacity; risk; resilience; nature-based features; climate change; storms; sea-level rise ID CLIMATE-CHANGE; DECISION-ANALYSIS; RESILIENCE; FRAMEWORK; DESIGN; SYSTEM AB Appropriate coastal zone management and storm-damage risk reduction requires the assessment of vulnerability in natural and human environments. Confusion arises, however, as vulnerability is conceptualized in many different ways and is closely related to other concepts such as risk and resilience. This paper defines nomenclature, presents a conceptual definition of vulnerability, and lays out a proposed conceptual approach for identifying and defining meaningful metrics to ensure a complete assessment of coastal vulnerability. While the focus of this paper is developing metrics for assessing vulnerability to coastal storms, the approach is valid for a wide range of systems and hazards at multiple scales and can explicitly consider the impacts of climate change. The approach is demonstrated through application to a simply coupled human-environment system on the coast and explicitly considers natural and nature-based features. C1 [Wamsley, Ty V.; Coffier, Zachary A.; Brodie, Katherine; Dunkin, Lauren M.; Rosati, Julie D.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Raff, David] US Army Corps Engineers, Inst Water Resources, Alexandria, VA 22315 USA. RP Wamsley, TV (reprint author), US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM Ty.V.Wamsley@usace.army.mil FU USACE North Atlantic Coast Comprehensive Study FX Permission was granted by the USACE Chief of Engineers to publish this material. The views and opinions expressed in this paper are those of the individual authors and not those of the U.S. Army or other sponsor organizations. This work was funded through the USACE North Atlantic Coast Comprehensive Study. NR 51 TC 5 Z9 5 U1 0 U2 12 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 EI 1551-5036 J9 J COASTAL RES JI J. Coast. Res. PD NOV PY 2015 VL 31 IS 6 BP 1521 EP 1530 DI 10.2112/JCOASTRES-D-14-00015.1 PG 10 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA CV4TY UT WOS:000364260600021 ER PT J AU Kokx-Ryan, M Cohen, J Cord, MT Walden, TC Makashay, MJ Sheffield, BM Brungart, DS AF Kokx-Ryan, Melissa Cohen, Julie Cord, Mary T. Walden, Therese C. Makashay, Matthew J. Sheffield, Benjamin M. Brungart, Douglas S. TI Benefits of Nonlinear Frequency Compression in Adult Hearing Aid Users SO JOURNAL OF THE AMERICAN ACADEMY OF AUDIOLOGY LA English DT Article DE adult; benefit; frequency lowering; hearing aid; nonlinear frequency compression; older adult ID LOWERED SPEECH; PERCEPTION; LISTENERS; ACCLIMATIZATION; INTELLIGIBILITY; TRANSPOSITION; RECOGNITION; OUTCOMES; CHILDREN; DEVICE AB Background: Frequency-lowering (FL) algorithms are an alternative method of providing access to high-frequency speech cues. There is currently a lack of independent research addressing: (1) what functional, measureable benefits FL provides; (2) which, if any, FL algorithm provides the maximum benefit, (3) how to clinically program algorithms, and (4) how to verify algorithm settings. Purpose: Two experiments were included in this study. The purpose of Experiment 1 was to (1) determine if a commercially available nonlinear frequency compression (NLFC) algorithm provides benefit as measured by improved speech recognition in noise when fit and verified using standard clinical procedures; and (2) evaluate the impact of acclimatization. The purpose of Experiment 2 was to (1) evaluate the benefit of using enhanced verification procedures to systematically determine the optimal application of a prototype NLFC algorithm, and (2) determine if the optimized prototype NLFC settings provide benefit as measured by improved speech recognition in quiet and in noise. Research Design: A single-blind, within-participant repeated measures design in which participants served as their own controls. Study Sample: Experiment 1 included 26 participants with a mean age of 68.3 yr and Experiment 2 included 37 participants with a mean age of 68.8 yr. Participants were recruited from the Audiology and Speech Pathology Center at Walter Reed National Military Medical Center in Bethesda, MD. Intervention: Participants in Experiment 1 wore bilateral commercially available hearing aids fit using standard clinical procedures and clinician expertise. Participants in Experiment 2 wore a single prototype hearing aid for which FL settings were systematically examined to determine the optimum application. In each experiment, FL-On versus FL-Off settings were examined in a variety of listening situations to determine benefit and possible implications. Data Collection and Analysis: In Experiment 1, speech recognition measures using the QuickSIN and Modified Rhyme Test stimuli were obtained at initial bilateral fitting and 3-5 weeks later during a follow-up visit. In Experiment 2, Modified Rhyme Test, /s partial derivative/, /integral partial derivative/ consonant discrimination task, and dual-task cognitive load speech recognition performance measures were conducted. Participants in Experiment 2 received four different systematic hearing aid programs during an initial visit and speech recognition data were collected over 2-3 follow-up sessions. Results: Some adults with hearing loss obtained small-to-moderate benefits from implementation of FL, while others maintained performance without detriment in both experiments. There was no significant difference among FL-On settings systematically obtained in Experiment 2. There was a modest but significant age effect in listeners of both experiments that indicated older listeners (>65 yr). might benefit more on average from FL than younger listeners. In addition, there were reliable improvements in the intelligibility of the phonemes /eta/ and /b/ for both groups, and /partial derivative/ for older listeners from the FL in both experiments. Conclusions: Although the optimum settings, application, and benefits of FL remain unclear at this time, there does not seem to be degradation in listener performance when FL is activated. The benefits of FL should be explored in older adult (>65 yr) listeners, as they tended to benefit more from FL applications. C1 [Kokx-Ryan, Melissa; Cohen, Julie; Cord, Mary T.; Walden, Therese C.; Makashay, Matthew J.; Sheffield, Benjamin M.; Brungart, Douglas S.] Walter Reed Natl Mil Med Ctr, Natl Mil Audiol & Speech Pathol Ctr, Bethesda, MD USA. [Kokx-Ryan, Melissa] Gallaudet Univ, Washington, DC 20002 USA. [Makashay, Matthew J.; Sheffield, Benjamin M.] US Army, Publ Hlth Command, Aberdeen Proving Ground, MD USA. RP Brungart, DS (reprint author), Audiol & Speech Pathol Ctr, Walter Reed Natl Mil Med Ctr, Bethesda, MD 20889 USA. EM douglas.s.brungart.civ@mail.mil FU Cooperative Research and Development Agreement (CRADA) with GN ReSound Corporation, Copenhagen, Denmark FX This research was supported in part through a Cooperative Research and Development Agreement (CRADA) with GN ReSound Corporation, Copenhagen, Denmark. NR 32 TC 1 Z9 1 U1 3 U2 11 PU AMER ACAD AUDIOLOGY PI RESTON PA 11730 PLAZA DR, STE 300, RESTON, VA 20190 USA SN 1050-0545 EI 2157-3107 J9 J AM ACAD AUDIOL JI J. Am. Acad. Audiol. PD NOV-DEC PY 2015 VL 26 IS 10 BP 838 EP 855 DI 10.3766/jaaa.15022 PG 18 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA CV1ER UT WOS:000363996900005 PM 26554489 ER PT J AU Fu, R Forsythe, E Shi, J Srour, M Blomquist, S Morton, D AF Fu, Richard Forsythe, Eric Shi, Jianmin Srour, Merric Blomquist, Steven Morton, David TI Temperature dependence of cesium carbonate-doped electron transporting layers on organic light-emitting diodes SO SYNTHETIC METALS LA English DT Article DE Organic materials; OLED devices; Electroluminescence; Electron transport; Electron injection; Cesium carbonate doping ID ELECTROLUMINESCENT DEVICES; INJECTION; EFFICIENCY; POLYMERS; ALUMINUM AB The temperature dependence and electronic transport properties of 1, 3, 5-tri(1-phenyl-1H-benzo[d] imidazol-2-yl) phenyl (TPBI) and 8-hydroxyquinoline aluminum (Alq) electron transporting layers (ETL) have been investigated as a function of cesium carbonate (Cs2CO3) doping for organic light emitting devices. The current-voltage and light emission characteristics were measured as a function of the Cs2CO3 doped ETL thickness at both room temperature and cryogenic (10-300K). The current density (I) for the Alq:Cs2CO3 ETL device increased for an ETL thickness between 100 and 300 angstrom, with no further increase in the ETL beyond 300 angstrom, indicating an electron injection limited contact. Conversely, the J for the TPBI: Cs2CO3 ETL device did not saturate for increasing ETL thicknesses confirming the TPBI:Cs2CO3 devices have a near-ohmic cathode contact. The correlation of current density-voltage (J-V) and luminance-voltage (L-V) for both Alq:Cs2CO3 and TPBI:Cs2CO3 devices were studied over temperatures from 10 to 300 K. Both increased with increasing temperature; however, Cs2CO3-doped TPBI devices were more effective than Cs2CO3-doped Alq devices. The observed differences between Alq and TPBI may be attributed to the exposed nitrogen electron pair in the electronic structure. Published by Elsevier B.V. C1 [Fu, Richard; Forsythe, Eric; Shi, Jianmin; Srour, Merric; Blomquist, Steven; Morton, David] US Army Res Lab, Adelphi, MD 20783 USA. RP Fu, R (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM richard.x.fu.civ@mail.mil NR 30 TC 0 Z9 0 U1 12 U2 36 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0379-6779 J9 SYNTHETIC MET JI Synth. Met. PD NOV PY 2015 VL 209 BP 128 EP 134 DI 10.1016/j.synthmet.2015.07.025 PG 7 WC Materials Science, Multidisciplinary; Physics, Condensed Matter; Polymer Science SC Materials Science; Physics; Polymer Science GA CV4OH UT WOS:000364245900019 ER PT J AU Weile, DS Hopkins, DA Gazonas, GA Powers, BM AF Weile, Daniel S. Hopkins, David A. Gazonas, George A. Powers, Brian M. TI On the proper formulation of Maxwellian electrodynamics for continuum mechanics (vol 26, pg 387, 2014) SO CONTINUUM MECHANICS AND THERMODYNAMICS LA English DT Correction C1 [Weile, Daniel S.] Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA. [Hopkins, David A.; Gazonas, George A.; Powers, Brian M.] APG, RDRL WMM B Army Res Lab, Aberdeen, MD 21005 USA. RP Weile, DS (reprint author), Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA. EM weile@udel.edu; david.a.hopkins.civ@mail.mil; george.a.gazonas.civ@mail.mil; brian.m.powers.civ@mail.mil NR 5 TC 0 Z9 0 U1 2 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0935-1175 EI 1432-0959 J9 CONTINUUM MECH THERM JI Continuum Mech. Thermodyn. PD NOV PY 2015 VL 27 IS 6 BP 1073 EP 1076 DI 10.1007/s00161-015-0457-y PG 4 WC Thermodynamics; Mechanics SC Thermodynamics; Mechanics GA CU8LG UT WOS:000363793500010 ER PT J AU Gorzalski, AS Spiesman, AL AF Gorzalski, Alexander S. Spiesman, Anne L. TI Insights on Chlorate Occurrence, Intra-system Variability, and Source Water Concentrations SO JOURNAL AMERICAN WATER WORKS ASSOCIATION LA English DT Editorial Material C1 [Gorzalski, Alexander S.] US Army Corps Engineers, Washington, DC 20016 USA. RP Gorzalski, AS (reprint author), US Army Corps Engineers, 5900 MacArthur Blvd NW, Washington, DC 20016 USA. EM Alexander.S.Gorzalski@usace.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER WATER WORKS ASSOC PI DENVER PA 6666 W QUINCY AVE, DENVER, CO 80235 USA SN 2164-4535 J9 J AM WATER WORKS ASS JI J. Am. Water Work Assoc. PD NOV PY 2015 VL 107 IS 11 BP 97 EP 97 DI 10.5942/jawwa.2015.107.0152 PG 1 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA CV0AX UT WOS:000363910200019 ER PT J AU Wei, XL Giuntini, D Maximenko, AL Haines, CD Olevsky, EA AF Wei, Xialu Giuntini, Diletta Maximenko, Andrey L. Haines, Christopher D. Olevsky, Eugene A. TI Experimental Investigation of Electric Contact Resistance in Spark Plasma Sintering Tooling Setup SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Article; Proceedings Paper CT 7th International Conference on Sintering CY AUG 24-28, 2014 CL Dresden, GERMANY ID TEMPERATURE DISTRIBUTION; FIELD; PRESSURE; CERAMICS; POWDER; MICROSTRUCTURE; DENSIFICATION; ACTIVATION; MECHANISMS; SIMULATION AB An experimental investigation on electric contact resistance in the tooling utilized in spark plasma sintering (SPS) is conducted. Two different SPS regimes are operated without the presence of processed powder to obtain the punch-punch (horizontal) and punch-die (vertical) contact resistance assessments separately. The processing temperature and applied pressure are considered to be the main factors that affect the contact resistance. These effects are analyzed by performing experiments at a maximum temperature of 1600 degrees C with constant heating rate of 100 degrees C/min. The applied pressure is ranging from 20 to 60MPa and a 1min holding time-step is used to ensure stable measurements. It is shown that the contact resistance goes down as the temperature ramps up. An increase in the pressure leads to a decrease in the contact resistance. The mechanisms that cause these variations in the contact resistance are discussed. The dependence of assessed contact resistance of the utilized SPS system on the processing temperature and applied pressure is analytically described based on the regression analysis of the collected experimental data. A finite-element simulation based on the obtained experimental results evidences that the electric contact resistance dominates the temperature evolution. The obtained results are of significant importance for modeling and optimization of SPS processes. C1 [Wei, Xialu; Giuntini, Diletta; Maximenko, Andrey L.; Olevsky, Eugene A.] San Diego State Univ, San Diego, CA 92182 USA. [Haines, Christopher D.] US Army ARDEC, Picatinny Arsenal, NJ 07806 USA. RP Wei, XL (reprint author), San Diego State Univ, 5500 Campanile Dr, San Diego, CA 92182 USA. EM xwei@mail.sdsu.edu NR 37 TC 7 Z9 7 U1 1 U2 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-7820 EI 1551-2916 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD NOV PY 2015 VL 98 IS 11 SI SI BP 3553 EP 3560 DI 10.1111/jace.13621 PG 8 WC Materials Science, Ceramics SC Materials Science GA CU6ZI UT WOS:000363683600021 ER PT J AU Finan, PH Quartana, PJ Smith, MT AF Finan, Patrick H. Quartana, Phillip J. Smith, Michael T. TI The Effects of Sleep Continuity Disruption on Positive Mood and Sleep Architecture in Healthy Adults SO SLEEP LA English DT Article DE sleep continuity disruption; positive mood; slow wave sleep; insomnia; sleep deprivation ID SLOW-WAVE ACTIVITY; MAJOR DEPRESSIVE DISORDER; PSYCHOLOGICAL RESILIENCE; PRIMARY INSOMNIA; REM-SLEEP; PAIN; DEPRIVATION; EMOTIONS; STRESS; LIFE AB Objective: The purpose of this study was to test an experimental model of the effects of sleep continuity disturbance on sleep architecture and positive mood in order to better understand the mechanisms linking insomnia and depression. Design: Participants were randomized to receive 3 consecutive nights of sleep continuity disruption via forced nocturnal awakenings (FA, n = 21), or one of two control conditions: restricted sleep opportunity (RSO, n = 17) or uninterrupted sleep (US, n = 24). Setting: The study was set in an inpatient clinical research suite. Participants: Healthy, good-sleeping men and women were included. Measurement and Results: Polysomnography was used to measure sleep architecture, and mood was assessed via self-report each day. Compared to restricted sleep opportunity controls, forced awakenings subjects had significantly less slow wave sleep (P < 0.05) after the first night of sleep deprivation, and significantly lower positive mood (P < 0.05) after the second night of sleep deprivation. The differential change in slow wave sleep statistically mediated the observed group differences in positive mood (P = 0.002). Conclusions: To our knowledge, this is the first human experimental study to demonstrate that, despite comparable reductions in total sleep time, partial sleep loss from sleep continuity disruption is more detrimental to positive mood than partial sleep loss from delaying bedtime, even when controlling for concomitant increases in negative mood. With these findings, we provide temporal evidence in support of a putative biologic mechanism (slow wave sleep deficit) that could help explain the strong comorbidity between insomnia and depression. C1 [Finan, Patrick H.; Smith, Michael T.] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21209 USA. [Quartana, Phillip J.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Washington, DC USA. RP Finan, PH (reprint author), Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, 5510 Nathan Shock Dr,Suite 100, Baltimore, MD 21209 USA. EM pfinan1@jhu.edu FU NIH [K23 DA035915, P30 NR014131]; [R21 NS051771]; [K23 NS47168] FX This was not an industry supported study. Funding sources: NIH K23 DA035915 and NIH P30 NR014131 to Dr. Finan; R21 NS051771, and K23 NS47168 both to Dr. Smith. The authors have indicated no financial conflicts of interest. NR 39 TC 13 Z9 14 U1 7 U2 30 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 EI 1550-9109 J9 SLEEP JI Sleep PD NOV 1 PY 2015 VL 38 IS 11 BP 1735 EP 1742 DI 10.5665/sleep.5154 PG 8 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA CU7RW UT WOS:000363740100013 PM 26085289 ER PT J AU Wilk, JE Quartana, PJ Clarke-Walper, K Kok, BC Riviere, LA AF Wilk, Joshua E. Quartana, Phillip J. Clarke-Walper, Kristina Kok, Brian C. Riviere, Lyndon A. TI Aggression in US soldiers post-deployment: Associations with combat exposure and PTSD and the moderating role of trait anger SO AGGRESSIVE BEHAVIOR LA English DT Article DE PTSD; anxiety; stress; impulsivity; trauma ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS; CHRONIC PAIN; MANAGEMENT STYLE; RISK-TAKING; IRAQ WAR; VETERANS; AFGHANISTAN; HOSTILITY; EXPRESSION AB Anger and aggression are among the most common issues reported by returning service members from combat deployments. However, the pathways between combat exposure and anger and aggression have not been comprehensively characterized. The present study aimed to characterize the relationship between trait anger, combat exposure, post-deployment PTSD, and aggression. U.S. Army soldiers (N=2,420) were administered anonymous surveys assessing combat exposure, current PTSD symptoms and aggression, as well as trait anger items 3 months after returning from deployment to Afghanistan. PTSD symptom levels were related to aggression at higher levels of trait anger, but not evident among soldiers who had lower levels of trait anger. The pathway from combat exposure to PTSD, and then to aggression, was conditional upon levels of trait anger, such that the pathway was most evident at high levels of trait anger. This was the first study to our knowledge that concurrently modeled unconditional and conditional direct and indirect associations between combat exposure, PTSD, trait anger, and aggression. The findings can be helpful clinically and for developing screening protocols for combat exposed Soldiers. The results of this study suggest the importance of assessing and managing anger and aggression in soldiers returning from combat deployment. Anger is one of the most common complaints of returning soldiers and can have debilitating effects across all domains of functioning. It is imperative that future research efforts are directed toward understanding this phenomenon and developing and validating effective treatments for it. Aggr. Behav. 41:556-565, 2015. Published 2015. This article is a U.S. Government work and is in the public domain in the USA C1 [Wilk, Joshua E.; Quartana, Phillip J.; Clarke-Walper, Kristina; Kok, Brian C.; Riviere, Lyndon A.] Walter Reed Army Inst Res, Mil Psychiat, Silver Spring, MD USA. RP Wilk, JE (reprint author), Walter Reed Army Inst Res, Mil Psychiat Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM joshua.e.wilk.civ@mail.mil NR 46 TC 1 Z9 1 U1 7 U2 17 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0096-140X EI 1098-2337 J9 AGGRESSIVE BEHAV JI Aggressive Behav. PD NOV-DEC PY 2015 VL 41 IS 6 BP 556 EP 565 DI 10.1002/ab.21595 PG 10 WC Behavioral Sciences; Psychology, Multidisciplinary SC Behavioral Sciences; Psychology GA CU2AU UT WOS:000363324400005 PM 26205643 ER PT J AU Atkinson, C Banks, K AF Atkinson, Chris Banks, Kevin TI Imaging Idiopathic Chylopericardium With Tc-99m-SC Lymphoscintigraphy and SPECT/CT SO CLINICAL NUCLEAR MEDICINE LA English DT Article DE chylopericardium; idiopathic chylopericardium; Tc-99m-SC; SPECT; CT; lymphoscintigraphy AB A 27-year-old asymptomatic active duty military man underwent a screening chest x-ray secondary to a history of tuberculosis exposure. His chest x-ray showed no features of tuberculosis infection but unexpectedly revealed a markedly enlarged cardiac silhouette. Echocardiography demonstrated a large pericardial effusion without tamponade physiology. Pericardiocentesis revealed chylous fluid. The effusion was initially refractory to drainage requiring VATS for therapy. Lymphoscintigraphy was performed using Tc-99m-SC to evaluate lymphatic anatomy and confirm communication with the pericardial space. Novel use was made of SPECT/CT with the hope of better assessing the nature of the abnormal communication and potentially helping guide management. C1 [Atkinson, Chris; Banks, Kevin] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Atkinson, C (reprint author), Brooke Army Med Ctr, Dept Radiol, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM cjatkinson@gmail.com NR 8 TC 2 Z9 2 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0363-9762 EI 1536-0229 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD NOV PY 2015 VL 40 IS 11 BP e508 EP e510 DI 10.1097/RLU.0000000000000944 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA CT8CQ UT WOS:000363043000005 PM 26284770 ER PT J AU Breckenridge-Sproat, ST Throop, MD Raju, D Murphy, DA Loan, LA Patrician, PA AF Breckenridge-Sproat, Sara T. Throop, Meryia D. Raju, Dheeraj Murphy, Deborah A. Loan, Lori A. Patrician, Patricia A. TI Building a Unit-Level Mentored Program to Sustain a Culture of Inquiry for Evidence-Based Practice SO CLINICAL NURSE SPECIALIST LA English DT Article DE culture; evidence-based practice; mentor; military healthcare; organizational change ID ACADEMIC-MEDICAL-CENTER; NURSING PRACTICE; HEALTH-CARE; NURSES; IMPLEMENTATION; EBP; INFRASTRUCTURE; DETERMINANTS; KNOWLEDGE; ATTITUDES AB Purpose: This study tested the effectiveness of a dynamic educational and mentoring program, facilitated by unit-level mentors, to introduce, promote, and sustain an evidence-based practice (EBP) culture among nurses in a military healthcare setting. Background: The need to identify gaps in practice, apply principles of EBP, and advance scientific applications in the pursuit of quality nursing care is as important to military healthcare as it is in the civilian sector. Description: The Advancing Research through Close Collaboration Model guided the intervention and study. Three instruments were used: the Organizational Readiness for System-wide Integration of Evidence-Based Practice, EBP Beliefs, and EBP Implementation scales. The study took place in 3 military hospitals simultaneously undergoing facility and staff integration. Data were collected from staff nurses in the inpatient nursing units before and after a facilitated education and mentoring intervention. Outcome: Three hundred sixty nurses (38%) completed baseline, and 325 (31%) completed follow-up surveys. Scores improved on all 3 measures following implementation of the program; however, the differences were statistically significant only for the Organizational Readiness for System-wide Integration of Evidence-Based Practice scale (70.96 vs 77.63, t=-3.95, P<.01). In the paired individual pretest/posttest subsample (n=56), scores improved significantly on all 3 instruments. Conclusions: Despite typically high turnover rates of military personnel and restructuring of 3 facilities during the study period, the readiness for, beliefs about, and implementation of EBP improved. This study suggests that a commitment to an EBP culture may diffuse among individuals in an organization, even while experiencing significant change. It also demonstrates that a unit-level mentored EBP program is sustainable despite changes in organizational structure and workforce composition. C1 [Breckenridge-Sproat, Sara T.] US Army, Europe Reg Med Command, Sembach, Germany. [Throop, Meryia D.] Tripler Army Med Ctr, Ctr Nursing Sci & Clin Inquiry, Honolulu, HI 96859 USA. [Raju, Dheeraj; Patrician, Patricia A.] Univ Alabama Birmingham, Sch Nursing, Birmingham, W Midlands, England. [Murphy, Deborah A.] Network Res Program, Natl Intrepid Ctr Excellence, Washington, DC USA. [Loan, Lori A.] Univ Alabama Birmingham, Sch Nursing, Family Community & Hlth Syst, Birmingham, W Midlands, England. RP Breckenridge-Sproat, ST (reprint author), CMR 402,Box 946, D-09180 APO, AE, Germany. EM sara.t.breckenridgesproat.mil@mail.mil FU TriService Nursing Research Program, Uniformed Services University of the Health Sciences [N10-P02] FX This project was funded by the TriService Nursing Research Program, Uniformed Services University of the Health Sciences (grant N10-P02). NR 48 TC 0 Z9 0 U1 3 U2 12 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0887-6274 EI 1538-9782 J9 CLIN NURSE SPEC JI Clin. Nurse Spec. PD NOV-DEC PY 2015 VL 29 IS 6 BP 329 EP 337 DI 10.1097/NUR.0000000000000161 PG 9 WC Nursing SC Nursing GA CU1YT UT WOS:000363319000010 PM 26444511 ER PT J AU Bose, A Dowding, RJ Johnson, JL AF Bose, Animesh Dowding, Robert J. Johnson, John L. TI SPECIAL ISSUE: THE 2014 INTERNATIONAL CONFERENCE ON TUNGSTEN, REFRACTORY & HARDMATERIALS SO INTERNATIONAL JOURNAL OF REFRACTORY METALS & HARD MATERIALS LA English DT Editorial Material C1 [Bose, Animesh] Mat Proc Inc, Irving, TX 75038 USA. [Dowding, Robert J.] US Army Res Lab, RDRL WMM, Aberdeen Proving Ground, MD 21005 USA. [Johnson, John L.] Elmet Technol LLC, Lewiston, ME 04240 USA. RP Bose, A (reprint author), Mat Proc Inc, 3101 Skyway Circle North, Irving, TX 75038 USA. EM animeshbose53@gmail.com; robert.j.dowding.civ@mail.mil; jjohnson@elmettech.com NR 0 TC 0 Z9 0 U1 1 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0263-4368 J9 INT J REFRACT MET H JI Int. J. Refract. Met. Hard Mat. PD NOV PY 2015 VL 53 SI SI BP 67 EP 67 DI 10.1016/j.ijrmhm.2015.07.013 PN B PG 1 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA CT8QO UT WOS:000363081300001 ER PT J AU Barnett, B Trexler, M Champagne, V AF Barnett, Blake Trexler, Matthew Champagne, Victor TI Cold sprayed refractory metals for chrome reduction in gun barrel liners SO INTERNATIONAL JOURNAL OF REFRACTORY METALS & HARD MATERIALS LA English DT Article DE Tungsten; Alloys & composites; Spray coating; Thermal spray coating AB Modern gun barrel technology faces a number of challenges related to the use of chrome-plated steel at the interior bore surface. The amount of allowable chrome has been significantly reduced due to environmental, health, and safety concerns. Furthermore, current munitions and propellants lead to erosion and condemnation of gun barrels well before their 10,000 round expected lifetime. This has precipitated a search for longer-lasting bore liners, such as refractory metals deposited by explosive bonding. The cost and difficulty associated with shaping these materials have made them impractical choices to date. Gas Dynamic Cold Spray consolidation of refractory metals and alloys was selected as an alternative to extrusion for additive manufacture of donor tubes. Tantalum-10 tungsten alloy donor tubes have been produced by cold spray and tested for compatibility with the cladding process. A 1-meter (3-foot) long tube was produced to test scalability. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Barnett, Blake] US Army Res Lab, Oak Ridge Inst Sci & Educ, Aberdeen Proving Ground, MD 21005 USA. [Trexler, Matthew; Champagne, Victor] US Army Res Lab, Ctr Cold Spray, Aberdeen Proving Ground, MD 21005 USA. RP Barnett, B (reprint author), US Army Res Lab, Oak Ridge Inst Sci & Educ, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. EM blake.d.barnett.ctr@mail.mil NR 12 TC 0 Z9 0 U1 6 U2 15 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0263-4368 J9 INT J REFRACT MET H JI Int. J. Refract. Met. Hard Mat. PD NOV PY 2015 VL 53 SI SI BP 139 EP 143 DI 10.1016/j.ijrmhm.2015.07.007 PN B PG 5 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA CT8QO UT WOS:000363081300013 ER PT J AU Buhr, TL Young, AA Barnette, HK Minter, ZA Kennihan, NL Johnson, CA Bohmke, MD DePaola, M Cora-Laoo, M Page, MA AF Buhr, T. L. Young, A. A. Barnette, H. K. Minter, Z. A. Kennihan, N. L. Johnson, C. A. Bohmke, M. D. DePaola, M. Cora-Lao, M. Page, M. A. TI Test methods and response surface models for hot, humid air decontamination of materials contaminated with dirty spores of Bacillus anthracis Delta Sterne and Bacillus thuringiensis Al Hakam SO JOURNAL OF APPLIED MICROBIOLOGY LA English DT Article DE Bacillus; decontamination; hot humid air; spore; surrogate ID BACTERIAL-SPORES; HEAT RESISTANCE; CHEMICAL STATES; WET-HEAT; SUBTILIS; CEREUS; HYDROPHOBICITY; DESTRUCTION; MECHANISM; TEMPERATURE AB Aims: To develop test methods and evaluate survival of Bacillus anthracis Sterne or Bacillus thuringiensis Al Hakam on materials contaminated with dirty spore preparations after exposure to hot, humid air using response surface modelling. Methods and Results: Spores (>7log(10)) were mixed with humic acid + spent sporulation medium (organic debris) or kaolin (dirt debris). Spore samples were then dried on five different test materials (wiring insulation, aircraft performance coating, anti-skid, polypropylene, and nylon). Inoculated materials were tested with 19 test combinations of temperature (55, 65, 75 degrees C), relative humidity (70, 80, 90%) and time (1, 2, 3days). The slowest spore inactivation kinetics was on nylon webbing and/or after addition of organic debris. Conclusions: Hot, humid air effectively decontaminates materials contaminated with dirty Bacillus spore preparations; debris and material interactions create complex decontamination kinetic patterns; and B.thuringiensis Al Hakam is a realistic surrogate for B.anthracis. Significance and Impact of the Study: Response surface models of hot, humid air decontamination were developed which may be used to select decontamination parameters for contamination scenarios including aircraft. C1 [Buhr, T. L.; Young, A. A.; Barnette, H. K.; Minter, Z. A.; Kennihan, N. L.; Johnson, C. A.; Bohmke, M. D.; DePaola, M.] Naval Surface Warfare Ctr, CBR Concepts & Expt Branch Z21, Dahlgren, VA 22448 USA. [Cora-Lao, M.; Page, M. A.] United States Army Corps Engineers Res & Dev Ctr, Champaign, IL USA. RP Buhr, TL (reprint author), Naval Surface Warfare Ctr, Dahlgren Div, CBR Concepts & Expt Branch Z21, 4045 Higley Rd,Suite 345, Dahlgren, VA 22448 USA. EM tony.buhr@navy.milu FU Defense Threat Reduction Agency Joint Science and Technology Office, Protection and Hazard Mitigation Capability Area [BA08PHM113] FX This work was supported through funding provided by the Defense Threat Reduction Agency Joint Science and Technology Office, Protection and Hazard Mitigation Capability Area (Project Number BA08PHM113). Dr. Chuck Bass is credited with the recommendation to test kaolin. We thank our colleagues at the Naval Surface Warfare Center, Dahlgren Division, particularly Emily B. Osborn, Derrell McPherson and Stephen Avila for technical support. NR 67 TC 2 Z9 2 U1 1 U2 14 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1364-5072 EI 1365-2672 J9 J APPL MICROBIOL JI J. Appl. Microbiol. PD NOV PY 2015 VL 119 IS 5 BP 1263 EP 1277 DI 10.1111/jam.12928 PG 15 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA CU3SG UT WOS:000363444800006 PM 26258399 ER PT J AU Cox, TJ Turner, DF Pelletier, GJ Navato, A AF Cox, Timothy J. Turner, Daniel F. Pelletier, Greg J. Navato, Alfred TI Stochastic Water Quality Modeling of an Impaired River Impacted by Climate Change SO JOURNAL OF ENVIRONMENTAL ENGINEERING LA English DT Article DE Water quality; Modeling; Climate change; Temperature; Dissolved oxygen; Stochastic ID THERMAL TOLERANCE; NORTH-AMERICA; TEMPERATURE; SALMON; BASIN; UNCERTAINTY; RESOURCES; AUSTRALIA; REGIMES; STREAMS AB A new stochastic water quality modeling tool was applied to quantify potential climate change effects on a nutrient impaired reach in the Pacific Northwest. This tool allows for multiple stochastic inputs for steady state river water quality simulations. A previously published calibrated deterministic model of the targeted reach was adapted for this study. This model simulates steady-state nutrient, algae, and dissolved oxygen dynamics with both point and nonpoint pollutant loadings. It also includes simulation of diurnally varying water temperature, calculated as a function of air temperature, shading, and streamflow using heat budget equations. For this study, local summer air temperature and critical low flows were treated stochastically in the model. Parameterization of these inputs was based on analysis of multiple global climate model (GCM) projections for the study area corresponding to a 2060 planning horizon. Continuous probability distribution functions were fitted to ensemble GCM data sets grouped according to two different greenhouse gas emission scenarios (best case, worst case). Climate projections were translated into summer low flows using a simple empirical regression hydrologic model that was developed on the basis of observed historical data. Model outputs are provided probabilistically, helping to quantify levels of climate model consensus and capturing a portion of the large uncertainty associated with the forecasts. This type of framework is valuable in its support of planning decision making. Results specific to this study indicate that, whereas reach dissolved oxygen and algae biomass levels are relatively insensitive to projected climate change, simulated stream water temperature changes could have an adverse effect on native salmon populations in the region. The demonstrated methods are believed to be generally transferable to other river water quality studies and are recommended as an option for planning studies. (C) 2015 American Society of Civil Engineers. C1 [Cox, Timothy J.] CDM Smith, Denver, CO 80202 USA. [Turner, Daniel F.] US Army Corps Engineers, Portland, OR USA. [Pelletier, Greg J.] Dept Ecol, Olympia, WA 98503 USA. [Navato, Alfred] CDM Smith, Carlsbad, CA 92008 USA. RP Cox, TJ (reprint author), CDM Smith, Suite 1100, Denver, CO 80202 USA. EM coxtj@cdmsmith.com OI Pelletier, Gregory/0000-0003-3823-0090 NR 41 TC 0 Z9 0 U1 2 U2 17 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9372 EI 1943-7870 J9 J ENVIRON ENG JI J. Environ. Eng.-ASCE PD NOV PY 2015 VL 141 IS 11 AR 04015035 DI 10.1061/(ASCE)EE.1943-7870.0000971 PG 11 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA CT8TE UT WOS:000363088600010 ER PT J AU Owens, BD Williams, AE Wolf, JM AF Owens, Brett D. Williams, Allison E. Wolf, Jennifer M. TI Risk factors for surgical complications in rotator cuff repair in a veteran population SO JOURNAL OF SHOULDER AND ELBOW SURGERY LA English DT Article DE Rotator cuff; repair; veteran; arthroscopy ID SURGERY; ARTHROPLASTY; INFECTION; MORTALITY; AFFAIRS AB Background: Technical advances have allowed arthroscopic rotator cuff repair to supplant open repairs with similar outcomes. However, few data exist to support the theoretical decrease in complications with the arthroscopic technique. Methods: We used the Veterans Administration Surgical Quality Improvement Program database from the entire U.S. Veterans Administration system. We obtained perioperative data of all patients undergoing rotator cuff repair between 2003 and 2008. Single and multivariate analyses were performed to evaluate risk factors for perioperative complications associated with rotator cuff surgery. Results: There were 6975 open rotator cuff repairs and 2918 arthroscopic rotator cuff repairs performed with similar patient age, gender breakdown, body mass index, and comorbidities. Complications occurred in the early postoperative period in 2.1% of the open repair group and 0.9% of the arthroscopic repair group (P < .0001). The prevalence of both superficial and deep wound infection was higher in the open group compared with the arthroscopic group (1% vs. 0.1% superficial, P < .0001; 0.3% vs. 0.1% deep, P = .11). Return to the operating room within the 30-day surveillance period occurred in 1.1% of the open repair patients compared with 0.5% of patients undergoing arthroscopic repairs (P < . 0001). -Multivariate logistic regression analysis revealed that the arthroscopic group had a significantly lower risk of complications (P = .0001), a lower rate of superficial infection (P = .0002), a lower incidence of return to the operating room within 30 days (P = .007), and a lower risk of hospital readmission (P < .0001). Conclusion: Arthroscopic rotator cuff repair in the veteran population resulted in a lower incidence of perioperative complications compared with open repair. Published by Elsevier Inc. on behalf of Journal of Shoulder and Elbow Surgery Board of Trustees. C1 [Owens, Brett D.; Williams, Allison E.; Wolf, Jennifer M.] Bay Pines VA Healthcare Syst, Bay Pines, FL USA. [Owens, Brett D.] Keller Army Hosp, West Point, NY 10996 USA. [Owens, Brett D.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. [Wolf, Jennifer M.] Univ Connecticut, Ctr Hlth, Dept Orthoped Surg, New England Musculoskeletal Inst, Farmington, CT USA. RP Owens, BD (reprint author), Keller Army Hosp, West Point, NY 10996 USA. EM owensbrett@gmail.com FU Mitek Sports Medicine and Musculoskeletal Transplant Foundation FX Brett D. Owens is a paid consultant for Mitek Sports Medicine and Musculoskeletal Transplant Foundation. All the other authors, their immediate families, and any research foundation with which they are affiliated have not received any financial payments or other benefits from any commercial entity related to the subject of this article. NR 21 TC 0 Z9 0 U1 1 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 1058-2746 J9 J SHOULDER ELB SURG JI J. Shoulder Elbow Surg. PD NOV PY 2015 VL 24 IS 11 BP 1707 EP 1712 DI 10.1016/j.jse.2015.04.020 PG 6 WC Orthopedics; Sport Sciences; Surgery SC Orthopedics; Sport Sciences; Surgery GA CU1FE UT WOS:000363264600010 PM 26164483 ER PT J AU Taylor, ODS Lee, TA Lester, AP AF Taylor, Oliver-Denzil S. Lee, Theodore A., III Lester, Alanna P. TI Hazard and Risk Potential of Unconventional Hydrocarbon Development-Induced Seismicity within the Central United States SO NATURAL HAZARDS REVIEW LA English DT Article DE Induced seismicity; Unconventional hydrocarbon production; Hazard; Risk ID WASTE-WATER INJECTION; DEEP GOLD-MINES; EARTHQUAKE SEQUENCE; OKLAHOMA; FLUID; ARKANSAS; QUARTZ; LEVEL AB Unconventional hydrocarbon development-induced seismic hazard in historically aseismic regions is more frequent and concentrated than seismicity in established tectonic high-hazard zones, and the current standard of practice for risk assessment for infrastructure is not applicable for this highly variable, induced hazard. A substantial seismic increase has been observed in historically aseismic regions and in close proximity to federal infrastructure within Arkansas, Kentucky, Missouri, Oklahoma, Tennessee, Texas, and Virginia. Seismological events M2.0 and greater, spanning February 8, 1950 until October 20, 2013 were analyzed to identify and assess the hazard potential. Geospatial and temporal observations correlate the seismic increase to the rise of unconventional hydrocarbon development, wherein all production components contribute to weakening of the subsurface and induced seismicity. Unconventional hydrocarbon production hazard has become more analogous with deep ore mining in terms of energy release and is subjected to the same causality phenomena and associative hazards with significant implications towards quantifying the risk to infrastructure health and longevity. (C) 2015 American Society of Civil Engineers. C1 [Taylor, Oliver-Denzil S.] US Army, Corps Engineers, Engineer Res & Dev Ctr, Geotech & Struct Lab,CEERD GS S, Vicksburg, MS 39180 USA. [Lee, Theodore A., III] US Army, Corps Engineers, Engineer Res & Dev Ctr, USACE Reachback Operat Ctr, Mobile, AL 36602 USA. [Lester, Alanna P.] US Army, Corps Engineers, Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. RP Taylor, ODS (reprint author), US Army, Corps Engineers, Engineer Res & Dev Ctr, Geotech & Struct Lab,CEERD GS S, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM oliver.d.taylor@usace.army.mil NR 90 TC 0 Z9 0 U1 3 U2 11 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1527-6988 EI 1527-6996 J9 NAT HAZARDS REV JI Nat. Hazards Rev. PD NOV PY 2015 VL 16 IS 4 AR UNSP 04015008 DI 10.1061/(ASCE)NH.1527-6996.0000178 PG 16 WC Engineering, Civil; Environmental Studies; Geosciences, Multidisciplinary; Meteorology & Atmospheric Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Geology; Meteorology & Atmospheric Sciences; Water Resources GA CT8TR UT WOS:000363089900006 ER PT J AU Briggs, MJ Kopp, PJ Silver, AL Wiggins, W AF Briggs, M. J. Kopp, P. J. Silver, A. L. Wiggins, W. TI Probabilistic model for predicting deep-draught channel design: Savannah, GA entrance channel SO OCEAN ENGINEERING LA English DT Article DE Vertical ship motions; Underkeel clearance; Deep draught navigation; Entrance channel design; Numerical models; Risk-based design ID WATER AB A vertical ship motion study was conducted to evaluate three proposed channel alignments S-1, S-3, and S-8 in the Savannah, GA entrance channel. These alignment changes (doglegs) are proposed to allow ships to reach deeper water in less distance, with reduced dredging costs. The Channel Analysis and Design Evaluation Tool (CADET) was used to predict the underkeel clearance and annual days of accessibility. The clearance and accessibility results were calculated for each channel option and include vertical ship motion allowances based on the wave-induced coupled heave, roll, and pitch. This provides a risk-based method of determining channel project depth based on two ship loading conditions for the three channel alignment options. Published by Elsevier Ltd. C1 [Briggs, M. J.] Briggs Grp LLC, Vicksburg, MS 39180 USA. [Kopp, P. J.; Silver, A. L.] Naval Surface Warfare Ctr, Surface Ship Hydromech Div, Carderock Div, West Bethesda, MD 20817 USA. [Wiggins, W.] US Army Corps Engineers, Savannah, GA 31402 USA. [Briggs, M. J.] US Army Corps Engineers, Coastal & Hydraul Lab, Ctr Res & Dev, CEERD HN HH, Vicksburg, MS 39180 USA. RP Briggs, MJ (reprint author), Briggs Grp LLC, Vicksburg, MS 39180 USA. EM briggsm1@cablelynx.com FU Institute for Water Resources FX The authors wish to acknowledge Headquarters, US Army Corps of Engineers, Savannah District, and the Naval Surface Warfare Center, Carderock Division for authorizing publication of this paper. Particular thanks go to Capt Steven Carmel (Maersk Shipping) for supplying information on the Susan Maersk containership and to the Institute for Water Resources for CADET support. NR 26 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0029-8018 J9 OCEAN ENG JI Ocean Eng. PD NOV 1 PY 2015 VL 108 BP 276 EP 286 DI 10.1016/j.oceaneng.2015.07.047 PG 11 WC Engineering, Marine; Engineering, Civil; Engineering, Ocean; Oceanography SC Engineering; Oceanography GA CU2HY UT WOS:000363345800023 ER PT J AU Annang, L Spencer, SM Jackson, D Rosemond, TN Best, AL Williams, LR Carlos, B AF Annang, Lucy Spencer, S. Melinda Jackson, Dawnyea Rosemond, Tiara N. Best, Alicia L. Williams, Leah R. Carlos, Bethany TI Developing a cancer prevention programme for African-American daughters and mothers SO HEALTH EDUCATION JOURNAL LA English DT Article DE African-American women; cancer prevention; daughters; mothers; nominal group technique ID BREAST-CANCER; HEALTH-PROMOTION; PROSTATE-CANCER; WOMEN; PERCEPTIONS; TALK; FEAR AB Objective: To describe how nominal group technique was used to inform the development of a breast and cervical cancer awareness programme for African-American adult daughters and mothers. Design: A qualitative approach using nominal group technique. Setting: A mid-sized city in the Southern USA. Method: Nominal group technique was used with 30 African-American daughters (ages 18-35 years) and 19 mothers (mothers of women aged 18-35 years). Daughter groups and mother groups were conducted separately. Responses were tallied and audio recordings were reviewed to provide context and/or clarity to participant responses. Results: In many cases, daughters and mothers had similar thoughts about what African-American women should be aware of, challenges of sharing breast/cervical cancer information between daughter and mother, and thoughts on what would make it easier to share such information. Many responses centred on elements of the communication dynamic between daughters and mothers, rather than specific content messaging about cancer. Recommendations are offered to inform the development of future programmes. Conclusion: Findings illustrate the potential to use upstream intergenerational communication effectively to relay health information between African-American daughters and mothers. Given that breast and cervical cancers have better survival rates when detected and treated early, and that late detection is associated with higher mortality among African-American women, conveying important health-related information from a trusted source (such as an adult daughter) is an important consideration for addressing the cancer prevention and control needs of African-American women. C1 [Annang, Lucy; Spencer, S. Melinda; Rosemond, Tiara N.] Univ S Carolina, Dept Hlth Promot Educ & Behav, Arnold Sch Publ Hlth, Columbia, SC 29208 USA. [Jackson, Dawnyea] US Army, Publ Hlth Command, Army Inst Publ Hlth, Aberdeen Proving Ground, MD USA. [Best, Alicia L.] HEALing Community Ctr, Res & Community Hlth, Atlanta, GA USA. [Williams, Leah R.] Hager Sharp Inc, Strateg Planning Res & Evaluat, Washington, DC USA. [Carlos, Bethany] Med Univ S Carolina, Coll Med, Charleston, SC 29425 USA. RP Annang, L (reprint author), Univ S Carolina, Dept Hlth Promot Educ & Behav, Arnold Sch Publ Hlth, 915 Greene St,Room 553, Columbia, SC 29208 USA. EM Lannang@sc.edu FU Department of Health Promotion, Education, and Behavior; Women's and Gender Studies Program at the University of South Carolina FX This study was funded by the Department of Health Promotion, Education, and Behavior and the Women's and Gender Studies Program at the University of South Carolina. NR 25 TC 0 Z9 0 U1 0 U2 3 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0017-8969 EI 1748-8176 J9 HEALTH EDUC J JI Health Educ. J. PD NOV PY 2015 VL 74 IS 6 BP 668 EP 680 DI 10.1177/0017896914557706 PG 13 WC Education & Educational Research; Public, Environmental & Occupational Health SC Education & Educational Research; Public, Environmental & Occupational Health GA CT7LK UT WOS:000362996000003 ER PT J AU Levy, JW Bhoomiboonchoo, P Simasathien, S Salje, H Huang, A Rangsin, R Jarman, RG Fernandez, S Klungthong, C Hussem, K Gibbons, RV Yoon, IK AF Levy, Jens W. Bhoomiboonchoo, Piraya Simasathien, Sriluck Salje, Henrik Huang, Angkana Rangsin, Ram Jarman, Richard G. Fernandez, Stefan Klungthong, Chonticha Hussem, Kittinun Gibbons, Robert V. Yoon, In-Kyu TI Elevated transmission of upper respiratory illness among new recruits in military barracks in Thailand SO INFLUENZA AND OTHER RESPIRATORY VIRUSES LA English DT Article DE Human; military; respiratory tract infections; Thailand; transmission AB Background New recruits within military barracks present conditions favorable for the spread of respiratory pathogens. However, respiratory pathogen transmission in such confined settings in the tropics has not been well studied. Methods Recruits in four successive Royal Thai Army basic training classes living in military barracks were monitored for the symptoms of influenza-like illness (ILI) or upper respiratory illness (URI). Classes 1 and 2 were also monitored after basic training. Nasal/ throat swabs from acute illnesses were collected and tested by influenza RT-PCR (all four classes). In addition, class 1 had multiplex PCR performed along with the analysis of bed locations within the barracks. Results Influenza-like illness/ upper respiratory illness rates ranged from 4.7 to 6.9 per 100 recruit-weeks in the four classes and generally decreased during the course of basic training (P < 0.05 in three of four classes). Rates during basic training were 1.7 (95% CI: 1.29, 2.29) and 2.5 (95% CI: 1.5, 4.1) times higher than after basic training (classes 1 and 2, respectively). In class 1, coronavirus, parainfluenza virus, and rhinovirus were the most commonly identified respiratory pathogens; only one influenza PCR-positive infection was detected in all four classes. Bed locations of URI/ ILI cases in class 1 tended to be in closer proximity to each other. Conclusion Basic training recruits in military barracks in the tropics had high rates of acute respiratory illnesses with illness patterns consistent with external seeding followed by substantial internal transmission. Our findings may contribute to control measures in similar confined settings both within and outside the military. C1 [Levy, Jens W.; Bhoomiboonchoo, Piraya; Huang, Angkana; Jarman, Richard G.; Fernandez, Stefan; Klungthong, Chonticha; Hussem, Kittinun; Gibbons, Robert V.; Yoon, In-Kyu] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Simasathien, Sriluck; Rangsin, Ram] Phramongkutklao Hosp, Bangkok, Thailand. [Salje, Henrik] Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. RP Levy, JW (reprint author), Armed Forces Res Inst Med Sci, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM jenslevy@gmail.com OI Salje, Henrik/0000-0003-3626-4254 NR 6 TC 1 Z9 1 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1750-2640 EI 1750-2659 J9 INFLUENZA OTHER RESP JI Influenza Other Respir. Viruses PD NOV PY 2015 VL 9 IS 6 BP 308 EP 314 DI 10.1111/irv.12345 PG 7 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA CT6ID UT WOS:000362915800006 ER PT J AU Pichyangkul, S Yongvanitchit, K Limsalakpetch, A Kum-Arb, U Im-Erbsin, R Boonnak, K Thitithayanont, A Jongkaewwattana, A Wiboon-Ut, S Mongkolsirichaikul, D Mahanonda, R Spring, M Chuang, I Mason, CJ Saunders, DL AF Pichyangkul, Sathit Yongvanitchit, Kosol Limsalakpetch, Amporn Kum-Arb, Utaiwan Im-Erbsin, Rawiwan Boonnak, Kobporn Thitithayanont, Arunee Jongkaewwattana, Anan Wiboon-ut, Suwimon Mongkolsirichaikul, Duangrat Mahanonda, Rangsini Spring, Michele Chuang, Ilin Mason, Carl J. Saunders, David L. TI Tissue Distribution of Memory T and B Cells in Rhesus Monkeys following Influenza A Infection SO JOURNAL OF IMMUNOLOGY LA English DT Article ID VIRUS-INFECTION; IMMUNE-RESPONSES; MEDIATED PROTECTION; NONHUMAN-PRIMATES; DENDRITIC CELLS; E-CADHERIN; LUNG; VACCINE; EXPRESSION; CHALLENGE AB Studies of influenza-specific immune responses in humans have largely assessed systemic responses involving serum Ab and peripheral blood T cell responses. However, recent evidence indicates that tissue-resident memory T (T-RM) cells play an important role in local murine intrapulmonary immunity. Rhesus monkeys were pulmonary exposed to 2009 pandemic H1N1 virus at days 0 and 28 and immune responses in different tissue compartments were measured. All animals were asymptomatic postinfection. Although only minimal memory immune responses were detected in peripheral blood, a high frequency of influenza nucleoprotein-specific memory T cells was detected in the lung at the "contraction phase," 49-58 d after second virus inoculation. A substantial proportion of lung nucleoprotein-specific memory CD8(+) T cells expressed CD103 and CD69, phenotypic markers of T-RM cells. Lung CD103(+) and CD103(-) memory CD8(+) T cells expressed similar levels of IFN-gamma and IL-2. Unlike memory T cells, spontaneous Ab secreting cells and memory B cells specific to influenza hemagglutinin were primarily observed in the mediastinal lymph nodes. Little difference in systemic and local immune responses against influenza was observed between young adult (6-8 y) and old animals (18-28 y). Using a nonhuman primate model, we revealed substantial induction of local T and B cell responses following 2009 pandemic H1N1 infection. Our study identified a subset of influenza-specific lung memory T cells characterized as T-RM cells in rhesus monkeys. The rhesus monkey model may be useful to explore the role of TRM cells in local tissue protective immunity after rechallenge and vaccination. C1 [Pichyangkul, Sathit; Yongvanitchit, Kosol; Limsalakpetch, Amporn; Kum-Arb, Utaiwan; Im-Erbsin, Rawiwan; Mongkolsirichaikul, Duangrat; Spring, Michele; Chuang, Ilin; Mason, Carl J.; Saunders, David L.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Boonnak, Kobporn] Mahidol Univ, Fac Trop Med, Dept Clin Trop Med, Bangkok 10400, Thailand. [Thitithayanont, Arunee; Wiboon-ut, Suwimon] Mahidol Univ, Dept Microbiol, Fac Sci, Bangkok 10400, Thailand. [Jongkaewwattana, Anan] Natl Ctr Genet Engn & Biotechnol, Pathum Thani 12120, Thailand. [Mahanonda, Rangsini] Chulalongkorn Univ, Fac Dent, Bangkok 10330, Thailand. RP Pichyangkul, S (reprint author), Armed Forces Res Inst Med Sci, Dept Immunol & Med, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM sathitp@afrims.org FU National Institutes of Health; National Institute of Allergy and Infectious Diseases [Y1-AI-5026-01]; Thailand Research Fund [BRG5880003]; Ratchadapisek endowment FX This work was supported by National Institutes of Health, National Institute of Allergy and Infectious Diseases Grant Y1-AI-5026-01, Thailand Research Fund Grant BRG5880003, and a Ratchadapisek endowment. NR 65 TC 5 Z9 5 U1 2 U2 5 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 EI 1550-6606 J9 J IMMUNOL JI J. Immunol. PD NOV 1 PY 2015 VL 195 IS 9 BP 4378 EP 4386 DI 10.4049/jimmunol.1501702 PG 9 WC Immunology SC Immunology GA CT7BQ UT WOS:000362968500035 PM 26408671 ER PT J AU Straskova, A Spidlova, P Mou, S Worsham, P Putzova, D Pavkova, I Stulik, J AF Straskova, Adela Spidlova, Petra Mou, Sherry Worsham, Patricia Putzova, Daniela Pavkova, Ivona Stulik, Jiri TI Francisella tularensis type B Delta dsbA mutant protects against type A strain and induces strong inflammatory cytokine and Th1-like antibody response in vivo SO PATHOGENS AND DISEASE LA English DT Article DE tularemia; cytokines; antibody response; protection; immunoproteomics ID COMPARATIVE PROTEOME ANALYSIS; LIVE VACCINE STRAIN; SUBSPECIES TULARENSIS; TULAREMIA; HOLARCTICA; VIRULENCE; PROTEINS; IDENTIFICATION; CIPROFLOXACIN; LIPOPROTEIN AB Francisella tularensis subspecies tularensis is a highly virulent intracellular bacterial pathogen, causing the disease tularemia. However, a safe and effective vaccine for routine application against F. tularensis has not yet been developed. We have recently constructed the deletion mutants for the DsbA homolog protein (Delta dsbA/FSC200) and a hypothetical protein IglH (Delta iglH/FSC200) in the type B F. tularensis subsp. holarctica FSC200 strain, which exerted different protection capacity against parental virulent strain. In this study, we further investigated the immunological correlates for these different levels of protection provided by Delta dsbA/FSC200 and Delta iglH/FSC200 mutants. Our results show that Delta dsbA/FSC200 mutant, but not Delta iglH/FSC200 mutant, induces an early innate inflammatory response leading to strong Th1-like antibody response. Furthermore, vaccination with Delta dsbA/FSC200 mutant, but not with Delta iglH/FSC200, elicited protection against the subsequent challenge with type A SCHU S4 strain in mice. An immunoproteomic approach was used to map a spectrum of antigens targeted by Th1-like specific antibodies, and more than 80 bacterial antigens, including novel ones, were identified. Comparison of tularemic antigens recognized by the Delta dsbA/FSC200 post-vaccination and the SCHU S4 post-challenge sera then revealed the existence of 22 novel SCHU S4 specific antibody clones. C1 [Straskova, Adela; Spidlova, Petra; Putzova, Daniela; Pavkova, Ivona; Stulik, Jiri] Univ Def, Fac Mil Hlth Sci, Dept Mol Pathol, Hradec Kralove 50001, Czech Republic. [Mou, Sherry; Worsham, Patricia] US Army, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. RP Straskova, A (reprint author), Acad Sci Czech Republic, Inst Microbiol, ALGATECH Ctr, Dept Phototroph Microorganisms, Trebesska 1575, Hradec Kralove 50001, Czech Republic. EM straskova@alga.cz FU Ministry of Education, Youth and Sports of Czech Republic [SV/FVZ201202]; DTRA [CB3387 PA D-CZ-11-0001]; long-term organization development plan [1011] FX The work was supported by Specific Research grant of Ministry of Education, Youth and Sports of Czech Republic (SV/FVZ201202), DTRA project CB3387 PA D-CZ-11-0001 and by a long-term organization development plan 1011. NR 35 TC 2 Z9 2 U1 4 U2 12 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 2049-632X J9 PATHOG DIS JI Pathog. Dis. PD NOV PY 2015 VL 73 IS 8 AR ftv058 DI 10.1093/femspd/ftv058 PG 12 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CT7FA UT WOS:000362978200003 PM 26253078 ER PT J AU Kessler, RC Stein, MB Bliese, PD Bromet, EJ Chiu, WT Cox, KL Colpe, LJ Fullerton, CS Gilman, SE Gruber, MJ Heeringa, SG Lewandowski-Romps, L Millikan-Bell, A Naifeh, JA Nock, MK Petukhova, MV Rosellini, AJ Sampson, NA Schoenbaum, M Zaslavsky, AM Ursano, RJ AF Kessler, R. C. Stein, M. B. Bliese, P. D. Bromet, E. J. Chiu, W. T. Cox, K. L. Colpe, L. J. Fullerton, C. S. Gilman, S. E. Gruber, M. J. Heeringa, S. G. Lewandowski-Romps, L. Millikan-Bell, A. Naifeh, J. A. Nock, M. K. Petukhova, M. V. Rosellini, A. J. Sampson, N. A. Schoenbaum, M. Zaslavsky, A. M. Ursano, R. J. CA Army STARRS Collaborators TI Occupational differences in US Army suicide rates SO PSYCHOLOGICAL MEDICINE LA English DT Article DE Army; Army STARRS; deployment; resiliency factors; suicide ID HEALTH-CARE UTILIZATION; RISK-FACTORS; MENTAL-HEALTH; MILITARY OCCUPATION; U.S. ARMY; RESILIENCE; DEPLOYMENT; SOLDIERS; WAR; STARRS AB Background. Civilian suicide rates vary by occupation in ways related to occupational stress exposure. Comparable military research finds suicide rates elevated in combat arms occupations. However, no research has evaluated variation in this pattern by deployment history, the indicator of occupation stress widely considered responsible for the recent rise in the military suicide rate. Method. The joint associations of Army occupation and deployment history in predicting suicides were analysed in an administrative dataset for the 729 337 male enlisted Regular Army soldiers in the US Army between 2004 and 2009. Results. There were 496 suicides over the study period (22.4/100 000 person-years). Only two occupational categories, both in combat arms, had significantly elevated suicide rates: infantrymen (37.2/100 000 person-years) and combat engineers (38.2/100 000 person-years). However, the suicide rates in these two categories were significantly lower when currently deployed (30.6/100 000 person-years) than never deployed or previously deployed (41.2-39.1/100 000 person-years), whereas the suicide rate of other soldiers was significantly higher when currently deployed and previously deployed (20.2-22.4/100 000 person-years) than never deployed (14.5/100 000 person-years), resulting in the adjusted suicide rate of infantrymen and combat engineers being most elevated when never deployed [ odds ratio (OR) 2.9, 95% confidence interval (CI) 2.1-4.1], less so when previously deployed (OR 1.6, 95% CI 1.1-2.1), and not at all when currently deployed (OR 1.2, 95% CI 0.8-1.8). Adjustment for a differential 'healthy warrior effect' cannot explain this variation in the relative suicide rates of never-deployed infantrymen and combat engineers by deployment status. Conclusions. Efforts are needed to elucidate the causal mechanisms underlying this interaction to guide preventive interventions for soldiers at high suicide risk. C1 [Kessler, R. C.; Chiu, W. T.; Gruber, M. J.; Petukhova, M. V.; Rosellini, A. J.; Sampson, N. A.; Zaslavsky, A. M.] Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 USA. [Stein, M. B.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA. [Stein, M. B.] Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA. [Stein, M. B.] VA San Diego Healthcare Syst, San Diego, CA USA. [Bliese, P. D.] Univ S Carolina, Darla Moore Sch Business, Columbia, SC 29208 USA. [Bromet, E. J.] SUNY Stony Brook, Dept Psychiat, Sch Med, Stony Brook, NY 11794 USA. [Cox, K. L.; Millikan-Bell, A.] US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA. [Colpe, L. J.] NIMH, Div Serv & Intervent Res, Bethesda, MD 20892 USA. [Fullerton, C. S.; Naifeh, J. A.; Ursano, R. J.] Uniformed Serv Univ Hlth Sci, Sch Med, Dept Psychiat, Ctr Study Traumat Stress, Bethesda, MD 20814 USA. [Gilman, S. E.] Harvard Univ, Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA 02115 USA. [Gilman, S. E.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Heeringa, S. G.; Lewandowski-Romps, L.] Univ Michigan, Inst Social Res, Ann Arbor, MI USA. [Nock, M. K.] Harvard Univ, Dept Psychol, Cambridge, MA 02138 USA. [Schoenbaum, M.] NIMH, Off Sci Policy Planning & Commun, Bethesda, MD 20892 USA. RP Kessler, RC (reprint author), Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 USA. EM kessler@hcp.med.harvard.edu OI Gilman, Stephen/0000-0002-8331-6419 FU Department of the Army; US Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health (NIH/NIMH) [U01MH 087981]; EPI-Q; Sanofi-Aventis Group; Walgreens Co.; Janssen FX Army STARRS was sponsored by the Department of the Army and funded under cooperative agreement number U01MH 087981 with the US Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health (NIH/NIMH). The contents are solely the responsibility of the authors and do not necessarily represent the views of the Department of Health and Human Services, the NIMH, the Department of the Army or the DoD. As a cooperative agreement, scientists employed by the NIMH (L. J. Colpe and M. Schoenbaum) and Army liaisons/consultants [Col. Steven Cersovsky, M.D., M.P.H. (US Army Public Health Command; USAPHC) and K. L. Cox, M.D., M.P.H. (USAPHC)] collaborated to develop the study protocol and data collection instruments, supervise data collection, interpret results and prepare reports. Although a draft of this manuscript was submitted to the Army and NIMH for review and comment prior to submission, this was with the understanding that comments would be no more than advisory. R. C. Kessler has been a consultant over the past 3 years for J & J Wellness & Prevention, Inc., Lake Nona Institute, Ortho-McNeil Janssen Scientific Affairs, Sanofi-Aventis Group, Shire US Inc. and Transcept Pharmaceuticals Inc. and has had research support for his epidemiological studies over this time period from EPI-Q, Sanofi-Aventis Group, and Walgreens Co. R. C. Kessler owns stock in DataStat, Inc. M. B. Stein has been a consultant for Healthcare Management Technologies and had research support for pharmacological imaging studies from Janssen. The remaining authors report nothing to disclose. NR 48 TC 1 Z9 1 U1 3 U2 15 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0033-2917 EI 1469-8978 J9 PSYCHOL MED JI Psychol. Med. PD NOV PY 2015 VL 45 IS 15 BP 3293 EP 3304 DI 10.1017/S0033291715001294 PG 12 WC Psychology, Clinical; Psychiatry; Psychology SC Psychology; Psychiatry GA CT7HZ UT WOS:000362986900015 PM 26190760 ER PT J AU Pun, GPP Darling, KA Kecskes, LJ Mishin, Y AF Pun, G. P. Purja Darling, K. A. Kecskes, L. J. Mishin, Y. TI Angular-dependent interatomic potential for the Cu-Ta system and its application to structural stability of nano-crystalline alloys SO ACTA MATERIALIA LA English DT Article DE Interatomic potential; Atomistic simulation; Immiscible alloys; Cu-Ta system; Grain boundaries ID EQUATION-OF-STATE; MOLECULAR-DYNAMICS SIMULATIONS; ALUMINUM-COPPER ALLOYS; EMBEDDED-ATOM METHOD; NI-AL SYSTEM; NANOCRYSTALLINE COPPER; VACANCY-FORMATION; TRANSITION-METALS; GRAIN-BOUNDARIES; CORE STRUCTURES AB Atomistic computer simulations are capable of providing insights into physical mechanisms responsible for the extraordinary structural stability and strength of immiscible Cu-Ta alloys. To enable reliable simulations of these alloys, we have developed an angular-dependent potential (ADP) for the Cu-Ta system by fitting to a large database of first-principles and experimental data. This, in turn, required the development of a new ADP potential for elemental Ta, which accurately reproduces a wide range of properties of Ta and is transferable to severely deformed states and diverse atomic environments. The new Cu-Ta potential is applied for studying the kinetics of grain growth in nano-crystalline Cu-Ta alloys with different chemical compositions. Ta atoms form nanometer-scale clusters preferentially located at grain boundaries (GBs) and triple junctions. These clusters pin some of the GBs in place and cause a drastic decrease in grain growth by the Zener pinning mechanism. The results of the simulations are well consistent with experimental observations and suggest possible mechanisms of the stabilization effect of Ta. (C) 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Pun, G. P. Purja; Mishin, Y.] George Mason Univ, Dept Phys & Astron, Fairfax, VA 22030 USA. [Darling, K. A.; Kecskes, L. J.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Mishin, Y (reprint author), George Mason Univ, Dept Phys & Astron, MSN 3F3, Fairfax, VA 22030 USA. EM ymishin@gmu.edu RI Mishin, Yuri/P-2020-2015 FU U.S. Army Research Office [W911NF-15-1-0077] FX We are grateful to Dr. Ramon Ravelo for providing first-principles data for the gamma surfaces and tensile compression stresses from Ref. [29] in numerical format, which enabled direct comparison with the ADP predictions in Figs. 3 and 6. This work was supported by the U.S. Army Research Office under a contract number W911NF-15-1-0077. NR 89 TC 6 Z9 6 U1 7 U2 30 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6454 EI 1873-2453 J9 ACTA MATER JI Acta Mater. PD NOV PY 2015 VL 100 BP 377 EP 391 DI 10.1016/j.actamat.2015.08.052 PG 15 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA CT2FC UT WOS:000362616400039 ER PT J AU Miao, X Xie, HJ Ackley, SF Perovich, DK Ke, CQ AF Miao, Xin Xie, Hongjie Ackley, Stephen F. Perovich, Donald K. Ke, Changqing TI Object-based detection of Arctic sea ice and melt ponds using high spatial resolution aerial photographs SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article DE Sea ice; Melt pond; Object-based classification; High spatial resolution imagery ID SURFACE CONDITIONS; SUMMER; CLASSIFICATION; COMPACTNESS; ALBEDO; SHAPE; SAR AB High resolution aerial photographs used to detect and classify sea ice features can provide accurate physical parameters to refine, validate, and improve climate models. However, manually delineating sea ice and melt ponds is time-consuming and labor-intensive. In this study, an object-based classification algorithm is developed to automatically extract sea ice and melt ponds efficiently from 163 aerial photographs taken during the Chinese National Arctic Research Expedition in summer 2010 (CHINARE 2010) in the Arctic Pacific Sector. The photographs are selected from 599 cloud-free photographs based on their image quality and representativeness in the marginal ice zone (MIZ). The algorithm includes three major steps: (1) the image segmentation groups the neighboring pixels into objects according to the similarity of spectral and textural information; (2) the random forest ensemble classifier distinguishes four general classes: water, general submerged ice (GSI, including melt ponds and submerged ice along ice edges), shadow, and ice/snow; and (3) the polygon neighbor analysis further separates melt ponds and submerged ice from the GSI according to their spatial relationships. The overall classification accuracy for the four general classes is 95.5% based on 178 ground reference objects. Furthermore, the producer's accuracy of 90.8% and user's accuracy of 91.8% are achieved for melt pond detection through 98 independent reference objects. For the 163 photos examined, a total of 19,438 melt ponds larger than 1 m(2) are detected, with a pond density of 867.2 km(-2), mean pond size of 32.6 +/- 0.03 m(2), and mean pond fraction of 0.06 +/- 0.006; a total of 42,468 ice floes are detected, with the mean floe size of 173.3 +/- 0.1 m(2) (majority in 1-30 m(2)) and mean ice concentration of 46.1 +/- 0.5% (ranging from 18.6-98.6%). These results matched well with ship-based visual observations in the MIZ in the same area and time. The method presented in the paper can be applied to data sets of high spatial resolution Arctic sea ice photographs for deriving detailed sea ice concentration, floe size, and melt pond distributions over wider regions, and extracting sea ice physical parameters and their corresponding changes between years. (C) 2015 Elsevier B.V. All rights reserved. C1 [Miao, Xin] Missouri State Univ, Dept Geog Geol & Planning, Springfield, MO 65897 USA. [Miao, Xin; Xie, Hongjie; Ackley, Stephen F.] Univ Texas San Antonio, Dept Geol Sci, San Antonio, TX 78249 USA. [Perovich, Donald K.] Erdc, CRREL, Hanover, NH 03755 USA. [Perovich, Donald K.] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. [Ke, Changqing] Nanjing Univ, Sch Geog & Oceanog Sci, Nanjing 210093, Jiangsu, Peoples R China. RP Miao, X (reprint author), Missouri State Univ, Dept Geog Geol & Planning, Springfield, MO 65897 USA. EM xinmiao@missouristate.edu; Hongjie.Xie@utsa.edu; Stephen.Ackley@utsa.edu; Donald.K.Perovich@erdc.dren.mil; kecq@nju.edu.cn RI Xie, Hongjie/B-5845-2009; OI Xie, Hongjie/0000-0003-3516-1210; Miao, Xin/0000-0001-8732-9105 FU ONR Sea State and Boundary Layer Physics of the Emerging Arctic DRI project [N000141310435]; Office of Naval Research FX Authors H. Xie and C. Ke want to thank the Chinese Arctic and Antarctic Administration for the opportunity to participate in the 2010 Chinese Arctic Expedition and colleagues Ruibo Lei, Wenfeng Huang and many others for collecting those aerial photos. Support for S.F. Ackley was provided by the ONR Sea State and Boundary Layer Physics of the Emerging Arctic DRI project, Wave-Ice and Air-Ice-Ocean Interaction During the Chukchi Sea Ice Edge Advance (award no. N000141310435). Support for D.K. Perovich was provided by the Office of Naval Research. NR 44 TC 4 Z9 4 U1 4 U2 32 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X EI 1872-7441 J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD NOV PY 2015 VL 119 BP 211 EP 222 DI 10.1016/j.coldregions.2015.06.014 PG 12 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA CS9AQ UT WOS:000362381900019 ER PT J AU Dangora, LM Hansen, CJ Mitchell, CJ Sherwood, JA Parker, JC AF Dangora, Lisa M. Hansen, Christopher J. Mitchell, Cynthia J. Sherwood, James A. Parker, Jason C. TI Challenges associated with shear characterization of a cross-ply thermoplastic lamina using picture frame tests SO COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING LA English DT Article DE Polymer (textile) fiber; Thermoplastic resin; Mechanical properties; Shear characterization ID COMPOSITE; INPLANE; REINFORCEMENT; DEFORMATION; BEHAVIOR; MELTS AB The current research investigates characterization of soft composite materials used in the manufacture of combat helmets. The material system considered is a cross-ply unidirectional (UD) sheet comprised of ultrahigh molecular weight polyethylene (UHMWPE) fibers consolidated with a polyurethane (PUR) based matrix. This paper presents efforts toward characterization of the material's shear behavior using the picture frame (a.k.a. trellis frame, shear frame, rhombus) test method and systematically investigates parameters influencing measurement of shear stiffness including sample arm geometry, forming temperature, strain rate, and mechanical conditioning. A specific emphasis is placed on the importance of arm geometry in the shear characterization. Overestimation of the force curve is found to result from interference of supporting arm material outside the central region of the test specimen. Removal of the excess arm material results in more accurate measurements of shear stiffness, which are subsequently available for input into FE models that simulate forming processes. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Dangora, Lisa M.; Hansen, Christopher J.; Mitchell, Cynthia J.; Sherwood, James A.] Univ Massachusetts, Dept Mech Engn, Lowell, MA 01854 USA. [Parker, Jason C.] US Army Natick Soldier Res, Dev & Engn Ctr, Natick, MA 01760 USA. RP Sherwood, JA (reprint author), Univ Massachusetts, Dept Mech Engn, 1 Univ Ave, Lowell, MA 01854 USA. EM james_sherwood@uml.edu FU US Army Natick Soldier Research, Development and Engineering Center (NSRDEC) [W911QY-1A-2-0001] FX The authors thank the US Army Natick Soldier Research, Development and Engineering Center (NSRDEC) for funding this research under contract number W911QY-1A-2-0001. The authors also recognize Lynne Samuelson and Ramaswamy Nagarajan of the Harnessing Emerging Research Opportunities to Empower Soldiers (HEROES) initiative for establishing this collaboration, and Daniel Regan of the Structural Dynamics and Acoustic Systems Laboratory for his assistance with DIC measurements and analysis. NR 32 TC 7 Z9 7 U1 2 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-835X EI 1878-5840 J9 COMPOS PART A-APPL S JI Compos. Pt. A-Appl. Sci. Manuf. PD NOV PY 2015 VL 78 BP 181 EP 190 DI 10.1016/j.compositesa.2015.08.015 PG 10 WC Engineering, Manufacturing; Materials Science, Composites SC Engineering; Materials Science GA CT2AT UT WOS:000362605100021 ER PT J AU Simsiriwong, J Shrestha, R Shamsaei, N Lugo, M Moser, RD AF Simsiriwong, Jutima Shrestha, Rakish Shamsaei, Nima Lugo, Marcos Moser, Robert D. TI Effects of microstructural inclusions on fatigue life of polyether ether ketone (PEEK) SO JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS LA English DT Article DE Thermoplastics; Fatigue life estimation; Structure-property relations; Strain-life approach; Fatigue modeling; Polyether ether ketone (PEEK) ID ALLOY AB In this study, the effects of microstructural inclusions on fatigue life of polyether ether ketone (PEEK) was investigated. Due to the versatility of its material properties, the semi-crystralline PEEK polymer has been increasingly adopted in a wide range of applications particularly as a biomaterial for orthopedic, trauma, and spinal implants. To obtain the cyclic behavior of PEEK, uniaxial fully-reversed strain-controlled fatigue tests were conducted at ambient temperature and at 0.02 mm/mm to 0.04 mm/mm strain amplitudes. The microstructure of PEEK was obtained using the optical and the scanning electron microscope (SEM) to determine the microstructural inclusion properties in PEEK specimen such as inclusion size, type, and nearest neighbor distance. SEM analysis was also conducted on the fracture surface of fatigue specimens to observe microstructural inclusions that served as the crack incubation sites. Based on the experimental strain-life results and the observed microstructure of fatigue specimens, a microstructure-sensitive fatigue model was used to predict the fatigue life of PEEK that includes both crack incubation and small crack growth regimes. Results show that the employed model is applicable to capture microstructural effects on fatigue behavior of PEEK. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Simsiriwong, Jutima; Shamsaei, Nima; Lugo, Marcos] Mississippi State Univ, Ctr Adv Vehicular Syst, Mississippi State, MS 39762 USA. [Shrestha, Rakish; Shamsaei, Nima] Mississippi State Univ, Dept Mech Engn, Mississippi State, MS 39762 USA. [Moser, Robert D.] US Army Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Simsiriwong, J (reprint author), Mississippi State Univ, Ctr Adv Vehicular Syst, Box 5405, Mississippi State, MS 39762 USA. EM jutima@cavs.msstate.edu FU U.S. Government [W15QKN-13-9-0001] FX This effort was sponsored by the U.S. Government under Other Transaction number W15QKN-13-9-0001 between the Consortium for Energy, Environment and Demilitarization, and the Government. The U.S. Government is authorized to reproduce and distribute reprints for Governmental purposes notwithstanding any copyright notation thereon. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of the U.S. Government. NR 22 TC 5 Z9 5 U1 4 U2 20 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1751-6161 EI 1878-0180 J9 J MECH BEHAV BIOMED JI J. Mech. Behav. Biomed. Mater. PD NOV PY 2015 VL 51 BP 388 EP 397 DI 10.1016/j.jmbbm.2015.07.020 PG 10 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA CT2AH UT WOS:000362603900035 PM 26301567 ER PT J AU Magnacca, KN Price, DK AF Magnacca, Karl N. Price, Donald K. TI Rapid adaptive radiation and host plant conservation in the Hawaiian picture wing Drosophila (Diptera: Drosophilidae) SO MOLECULAR PHYLOGENETICS AND EVOLUTION LA English DT Article DE Drosophila; Hawaii; Evolution; Adaptive radiation; Biogeography ID SPECIES GROUP; PHYLOGENETIC-RELATIONSHIPS; MOLECULAR PHYLOGENY; GEOGRAPHIC RANGE; DIVERGENCE TIMES; MIXED MODELS; EVOLUTION; DIVERSIFICATION; SPECIATION; DISPERSAL AB The Hawaiian picture wing Drosophila are a striking example of adaptive radiation in specialist saprophages on an island system. We use DNA sequences from five nuclear genes with a total of 4260 nucleotides to provide a comprehensive phylogeny and biogeographic analysis of 90 species in the Hawaiian Drosophila picture wing clade. The current analysis indicates that the evolution of the picture wing clade took place more recently than previously suggested. The relationships of several morphologically anomalous taxa are resolved with strong support. Biogeography and host plant analyses show two periods of rapid divergence occurred when Kauai and Oahu were the main high islands, indicating that a combination of complex topographical features of islands and development of novel host plant associations was key to the rapid diversification of these lineages. For the past 2 million years, host associations within lineages have been largely stable, and speciation has occurred primarily due to the establishment of populations on newer islands as they arose followed by divergence by isolation. The existence of several apparently relictual taxa suggests that extinction has also played a major role in assembly of the present Hawaiian Drosophila fauna. (C) 2015 Elsevier Inc. All rights reserved. C1 [Magnacca, Karl N.; Price, Donald K.] Univ Hawaii, Dept Biol, Hilo, HI 96721 USA. RP Magnacca, KN (reprint author), Oahu Army Nat Resource Program, 947 Wright Ave, Schofield Barracks, HI 96857 USA. EM knm956@gmail.com FU Gordon and Betty Moore Foundation FX We thank the Hawaii Department of Land and Natural Resources, Division of Forestry and Wildlife (particularly Cynthia King and Betsy Gagne) and Division of State Parks; Kapua Kawelo, Joby Rohrer, and many others at the Oahu Army Natural Resource Program; Pat Bily, Ed Misaki, and Russell Kallstrom of the Nature Conservancy; Mark Vaught of the East Maui Irrigation Co.; Keahi Bustamente of the Maui Plant Extinction Prevention Program; Randy Bartlett and the field crew of the East Maui Watershed Partnership; and Puu Kukui Watershed Preserve for permission to collect on their lands and assistance in the field. Listed endangered species were collected under USFWS permit TE-02997A-2. Thanks also to Steffen Oeser (University of Hawaii, John A. Burns School of Medicine) and Anne Veillet (University of Hawaii, Hilo) for assistance with sequencing. We also thank Patrick O'Grady (University of California, Berkeley) and an anonymous reviewer for helping improve the manuscript. This work was supported by a grant from the Gordon and Betty Moore Foundation to D.K.P. NR 74 TC 7 Z9 7 U1 6 U2 34 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1055-7903 EI 1095-9513 J9 MOL PHYLOGENET EVOL JI Mol. Phylogenet. Evol. PD NOV PY 2015 VL 92 BP 226 EP 242 DI 10.1016/j.ympev.2015.06.014 PG 17 WC Biochemistry & Molecular Biology; Evolutionary Biology; Genetics & Heredity SC Biochemistry & Molecular Biology; Evolutionary Biology; Genetics & Heredity GA CS9AO UT WOS:000362381700020 PM 26151218 ER PT J AU Heider, SA Dunn, WL AF Heider, S. A. Dunn, W. L. TI A simulation study of fast neutron interrogation for standoff detection of improvised explosive devices SO RADIATION PHYSICS AND CHEMISTRY LA English DT Article; Proceedings Paper CT 9th International Topical Meeting on Industrial Radiation and Radioisotope Measurement Applications CY JUL 06-11, 2014 CL Valencia, SPAIN DE Explosives; Detection; Neutrons; Signature analysis; Template matching AB The signature-based radiation-scanning technique utilizes radiation detector responses, called "signatures," and compares these to "templates" in order to differentiate targets that contain certain materials, such as explosives or drugs, from those that do not. Our investigations are aimed at the detection of nitrogen-rich explosives contained in improvised explosive devices. We use the term "clutter" to refer to any non-explosive materials with which the interrogating radiation may interact between source and detector. To deal with the many target types and clutter configurations that may be encountered in the field, the use of "artificial templates" is proposed. The MCNP code was used to simulate 14.1 MeV neutron source beams incident on one type of target containing various clutter and sample materials. Signatures due to inelastic-scatter and prompt-capture gamma rays from hydrogen, carbon, nitrogen, and oxygen and two scattered neutron signatures were considered. Targets containing explosive materials in the presence of clutter were able to be identified from targets that contained only non-explosive ("inert") materials. This study demonstrates that a finite number of artificial templates is sufficient for IED detection with fairly good sensitivity and specificity. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Heider, S. A.; Dunn, W. L.] Kansas State Univ, Dept Mech & Nucl Engn, Manhattan, KS 66506 USA. [Heider, S. A.] US Mil Acad, West Point, NY 10996 USA. RP Dunn, WL (reprint author), Kansas State Univ, Dept Mech & Nucl Engn, 3002 Rathbone Hall, Manhattan, KS 66506 USA. EM dunn@ksu.edu FU United States Marine Corps Systems Command [M67854-02-D-1110] FX This work was partially funded through the award of contract M67854-02-D-1110 from the United States Marine Corps Systems Command to M2 Technologies, Inc. NR 8 TC 0 Z9 0 U1 2 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0969-806X J9 RADIAT PHYS CHEM JI Radiat. Phys. Chem. PD NOV PY 2015 VL 116 BP 341 EP 344 DI 10.1016/j.radphyschem.2015.04.013 PG 4 WC Chemistry, Physical; Nuclear Science & Technology; Physics, Atomic, Molecular & Chemical SC Chemistry; Nuclear Science & Technology; Physics GA CT2BE UT WOS:000362606200069 ER PT J AU Wang, D Abdelzaher, T Kaplan, L Ganti, R Hu, SH Liu, HC AF Wang, Dong Abdelzaher, Tarek Kaplan, Lance Ganti, Raghu Hu, Shaohan Liu, Hengchang TI Reliable social sensing with physical constraints: analytic bounds and performance evaluation SO REAL-TIME SYSTEMS LA English DT Article; Proceedings Paper CT IEEE 34th Real-Time Systems Symposium (RTSS) CY DEC 03-06, 2013 CL Vancouver, CANADA SP IEEE, IEEE Comp Soc, Tech Comm Real Time Syst DE Social sensing; Cyber-physical computing; Maximum likelihood estimation; Physical constraint; Analytic bounds ID MAXIMUM-LIKELIHOOD; EM ALGORITHM; SYSTEMS; ENVIRONMENT; TERMINATION; TASKS AB Correctness guarantees are at the core of cyber-physical computing research. While prior research addressed correctness of timing behavior and correctness of program logic, this paper tackles the emerging topic of assessing correctness of input data. This topic is motivated by the desire to crowd-source sensing tasks, an act we henceforth call social sensing, in applications with humans in the loop. A key challenge in social sensing is that the reliability of sources is generally unknown, which makes it difficult to assess the correctness of collected observations. To address this challenge, we adopt a cyber-physical approach, where assessment of correctness of individual observations is aided by knowledge of physical constraints on sources and observed variables to compensate for the lack of information on source reliability. We cast the problem as one of maximum likelihood estimation. The goal is to jointly estimate both (i) the latent physical state of the observed environment, and (ii) the inferred reliability of individual sources such that they are maximally consistent with both provenance information (who reported what) and physical constraints. We also derive new analytic bounds that allow the social sensing applications to accurately quantify the estimation error of source reliability for given confidence levels. We evaluate the framework through both a real-world social sensing application and extensive simulation studies. The results demonstrate significant performance gains in estimation accuracy of the new algorithms and verify the correctness of the analytic bounds we derived. C1 [Wang, Dong] Univ Notre Dame, Dept Comp Sci & Engn, Notre Dame, IN 46556 USA. [Abdelzaher, Tarek; Hu, Shaohan; Liu, Hengchang] Univ Illinois, Dept Comp Sci, Urbana, IL 61801 USA. [Kaplan, Lance] US Army Res Labs, Networked Sensing & Fus Branch, Adelphi, MD 20783 USA. [Ganti, Raghu] IBM Res, Yorktown Hts, NY 10598 USA. [Liu, Hengchang] Univ Sci & Technol China, Dept Comp Sci, Hefei 230027, Anhui, Peoples R China. RP Wang, D (reprint author), Univ Notre Dame, Dept Comp Sci & Engn, Notre Dame, IN 46556 USA. EM dwang5@nd.edu FU National Science Foundation [IIS-1447795]; Army Research Laboratory [W911NF-09-2-0053] FX Research reported in this paper was sponsored by National Science Foundation under Grant No. IIS-1447795 and Army Research Laboratory under Cooperative Agreement W911NF-09-2-0053. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation here on. NR 68 TC 1 Z9 1 U1 0 U2 4 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0922-6443 EI 1573-1383 J9 REAL-TIME SYST JI Real-Time Syst. PD NOV PY 2015 VL 51 IS 6 SI SI BP 724 EP 762 DI 10.1007/s11241-015-9238-8 PG 39 WC Computer Science, Theory & Methods SC Computer Science GA CT3YZ UT WOS:000362744100004 ER PT J AU Price, TF Harmon-Jones, E AF Price, Tom F. Harmon-Jones, Eddie TI Embodied emotion: the influence of manipulated facial and bodily states on emotive responses SO WILEY INTERDISCIPLINARY REVIEWS-COGNITIVE SCIENCE LA English DT Review ID FRONTAL CORTICAL ACTIVITY; ACTION-BASED MODEL; BRAIN ACTIVITY; APPETITIVE STIMULI; ASYMMETRY; EXPRESSIONS; EXPERIENCE; FEEDBACK; POSTURES; CATEGORIZATION AB A growing body of evidence suggests that certain facial expressions and postures are associated with emotional and motivational responses. This review discusses behavioral, neuroscientific, and cognitive research connecting these bodily movements with emotive responses. General bodily feedback theories of emotion have suggested that manipulated facial expressions and postures influence emotive reactions to stimuli as well as physiological responses such as heart rate, skin conductance, and the temperature of blood entering the brain. More recent evidence suggests that manipulated bodily states influence prefrontal cortical activation and amygdala activation. Even further evidence has suggested that manipulated bodily states influence cognitive processes, such as the speed at which individuals read emotional content, the speed at which they classify information as emotional, and the extent to which they determine emotional information as threatening. Bodily feedback theories may also suggest clinical applications. Bodily feedback theories of emotion therefore have generated research showing that bodily expressions play a pivotal role in our emotive experiences. (C) 2015 Wiley Periodicals, Inc. C1 [Price, Tom F.] Army Res Lab, Aberdeen, MD USA. [Harmon-Jones, Eddie] Univ New S Wales, Dept Psychol, Sydney, NSW, Australia. RP Harmon-Jones, E (reprint author), Univ New S Wales, Dept Psychol, Sydney, NSW, Australia. EM e.harmon-jones@unsw.edu.au NR 71 TC 3 Z9 3 U1 14 U2 50 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1939-5078 EI 1939-5086 J9 WIRES COGN SCI JI Wiley Interdiscip. Rev.-Cogn. Sci. PD NOV-DEC PY 2015 VL 6 IS 6 BP 461 EP 473 DI 10.1002/wcs.1370 PG 13 WC Psychology, Experimental SC Psychology GA CT3UH UT WOS:000362731900001 PM 26401657 ER PT J AU Wang, HS Bai, SQ Chen, LD Cuenat, A Joshi, G Kleinke, H Konig, J Lee, HW Martin, J Oh, MW Porter, WD Ren, ZF Salvador, J Sharp, J Taylor, P Thompson, AJ Tseng, YC AF Wang, Hsin Bai, Shengqiang Chen, Lidong Cuenat, Alexander Joshi, Giri Kleinke, Holger Koenig, Jan Lee, Hee Woong Martin, Joshua Oh, Min-Wook Porter, Wallace D. Ren, Zhifeng Salvador, James Sharp, Jeff Taylor, Patrick Thompson, Alan J. Tseng, Y. C. TI International Round-Robin Study of the Thermoelectric Transport Properties of an n-Type Half-Heusler Compound from 300 K to 773 K SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE Thermoelectric; figure of merit; ZT; round-robin ID BULK THERMOELECTRICS; LEAD-TELLURIDE; THERMAL-CONDUCTIVITY; FIGURE; MERIT; CRYSTAL; ZRNISN; SEMICONDUCTOR; SKUTTERUDITES; SUBSTITUTION AB International transport property-measurement round-robins have been conducted by the thermoelectric annex under the International Energy Agency (IEA) Implementing Agreement on Advanced Materials for Transportation (AMT). Two previous round-robins used commercially available bismuth telluride as the test material, with the objectives of understanding measurement issues and developing standard testing procedures. This round-robin extended the measurement temperature range to 773 K. It was designed to meet the increasing demands for reliable transport data for thermoelectric materials used for power-generation applications. Eleven laboratories from six IEA-AMT member countries participated in the study. A half-Heusler (n-type) material prepared by GMZ Energy was selected for the round-robin. The measured transport properties had a narrower distribution of uncertainty than previous round-robin results. The study intentionally included multiple testing methods and instrument types. Over the full temperature range, the measurement discrepancies for the figure of merit, ZT, in this round-robin were +/- 11.5 to +/- 16.4% from the averages. C1 [Wang, Hsin; Porter, Wallace D.] Oak Ridge Natl Lab, Oak Ridge, TN 37831 USA. [Bai, Shengqiang; Chen, Lidong] Chinese Acad Sci, Shanghai Inst Ceram, Shanghai 200050, Peoples R China. [Cuenat, Alexander] NPL, Teddington, Middx, England. [Joshi, Giri] GMZ Energy, Waltham, MA USA. [Kleinke, Holger] Univ Waterloo, Waterloo, ON N2L 3G1, Canada. [Koenig, Jan] Fraunhofer Inst Phys Measurement Tech, Freiburg, Germany. [Lee, Hee Woong; Oh, Min-Wook] Korea Electrotechnol Res Inst, Anshan, South Korea. [Martin, Joshua] NIST, Gaithersburg, MD 20899 USA. [Ren, Zhifeng] Univ Houston, Houston, TX USA. [Salvador, James] Gen Motors Global R&D, Warren, MI USA. [Sharp, Jeff; Thompson, Alan J.] Marlow Ind, Dallas, TX USA. [Taylor, Patrick] Army Res Lab, Adelphi, MD USA. [Tseng, Y. C.] CanmetMAT, Hamilton, ON, Canada. [Joshi, Giri] Evident Thermoelect, Troy, NY USA. RP Wang, HS (reprint author), Oak Ridge Natl Lab, Oak Ridge, TN 37831 USA. EM wangh2@ornl.gov RI Chen, Lidong/F-2705-2010; Wang, Hsin/A-1942-2013 OI Wang, Hsin/0000-0003-2426-9867 FU International Energy Agency; Natural Resources Canada; International S&T Cooperation Program of China [2015DFA51050]; Oak Ridge National Laboratory [DE-AC 05000OR22725] FX The paper describes work being conducted is part of the Implementing Agreement on Advanced Materials for Transportation under the auspices of the International Energy Agency. The authors would like to acknowledge financial support by Natural Resources Canada for the work conducted at CanmetMATERIALS, the International S&T Cooperation Program of China (2015DFA51050), and the home institution of each participating laboratory. HW would like to thank the assistant secretary for Energy Efficiency and Renewable Energy of the Department of Energy and the Propulsion Materials program under the Vehicle Technologies program, and Oak Ridge National Laboratory managed by UT-Battelle LLC under contract DE-AC 05000OR22725. NR 51 TC 4 Z9 4 U1 10 U2 48 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD NOV PY 2015 VL 44 IS 11 BP 4482 EP 4491 DI 10.1007/s11664-015-4006-z PG 10 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA CS2LS UT WOS:000361903000052 ER PT J AU Brame, J Long, MC Li, QL Alvarez, P AF Brame, Jonathon Long, Mingce Li, Qilin Alvarez, Pedro TI Inhibitory effect of natural organic matter or other background constituents on photocatalytic advanced oxidation processes: Mechanistic model development and validation SO WATER RESEARCH LA English DT Article DE Photocatalysis; TiO2; Inhibitory model; Natural organic matter; Reactive oxygen ID TITANIUM-DIOXIDE; WATER-TREATMENT; SINGLET OXYGEN; AQUEOUS SYSTEMS; DEGRADATION; TIO2; POLLUTANTS; REMOVAL; IRRADIATION; SUSPENSIONS AB The ability of reactive oxygen species (ROS) to interact with priority pollutants is crucial for efficient water treatment by photocatalytic advanced oxidation processes (AOPs). However, background compounds in water such as natural organic matter (NOM) can significantly hinder targeted reactions and removal efficiency. This inhibition can be complex, interfering with degradation in solution and at the photocatalyst surface as well as hindering illumination efficiency and ROS production. We developed an analytical model to account for various inhibition mechanisms in catalytic AOPs, including competitive adsorption of inhibitors, scavenging of produced ROS at the surface and in solution, and the inner filtering of the excitation illumination, which combine to decrease ROS-mediated degradation. This model was validated with batch experiments using a variety of ROS producing systems ((OH)-O-center dot-generating TiO2 photocatalyst and H2O2-UV; O-1(2)-generating photosensitive functionalized fullerenes and rose bengal) and inhibitory compounds (NOM, tert-butyl alcohol). Competitive adsorption by NOM and ROS scavenging were the most influential inhibitory mechanisms. Overall, this model enables accurate simulation of photocatalytic AOP performance when one or more inhibitory mechanisms are at work in a wide variety of application scenarios, and underscores the need to consider the effects of background constituents on degradation efficiency. Published by Elsevier Ltd. C1 [Brame, Jonathon; Li, Qilin; Alvarez, Pedro] Rice Univ, Dept Civil & Environm Engn, Houston, TX USA. [Long, Mingce] Shanghai Jiao Tong Univ, Sch Environm Sci & Engn, Shanghai 200030, Peoples R China. RP Alvarez, P (reprint author), US Army Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. EM alvarez@rice.edu NR 41 TC 6 Z9 6 U1 10 U2 66 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0043-1354 J9 WATER RES JI Water Res. PD NOV 1 PY 2015 VL 84 BP 362 EP 371 DI 10.1016/j.watres.2015.07.044 PG 10 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA CS5VW UT WOS:000362147400039 PM 26302091 ER PT J AU Ghoshal, A Ayers, J Gurvich, M Urban, M Bordick, N AF Ghoshal, Anindya Ayers, James Gurvich, Mark Urban, Michael Bordick, Nathaniel TI Experimental investigations in embedded sensing of composite components in aerospace vehicles (vol 71C, pg 52, 2015) SO COMPOSITES PART B-ENGINEERING LA English DT Correction C1 [Ghoshal, Anindya] US Army, Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA. [Ayers, James] Honeywell Aerosp, Mech Syst Struct & Dynam, Phoenix, AZ 85034 USA. [Gurvich, Mark] United Technol Res Ctr, E Hartford, CT 06105 USA. [Urban, Michael] Sikorsky Aircraft Corp, Stratford, CT 06615 USA. [Bordick, Nathaniel] Army Aviat Appl Technol Directorate, Ft Eustis, VA 23604 USA. RP Ghoshal, A (reprint author), US Army, Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA. EM anindya.ghoshal.civ@mail.mil NR 1 TC 0 Z9 0 U1 2 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-8368 EI 1879-1069 J9 COMPOS PART B-ENG JI Compos. Pt. B-Eng. PD NOV PY 2015 VL 81 BP 276 EP 276 DI 10.1016/j.compositesb.2015.01.001 PG 1 WC Engineering, Multidisciplinary; Materials Science, Composites SC Engineering; Materials Science GA CR5TF UT WOS:000361406300024 ER PT J AU Goldberg, B Cannon-Bowers, J AF Goldberg, Benjamin Cannon-Bowers, Janis TI Feedback source modality effects on training outcomes in a serious game: Pedagogical agents make a difference SO COMPUTERS IN HUMAN BEHAVIOR LA English DT Article DE Intelligent tutoring systems; Explicit feedback; Pedagogical agents; Generalized intelligent framework for tutoring; Game-based training; Cognitive load ID SUBJECTIVE MENTAL WORKLOAD; NASA-TLX; SYSTEMS; ENVIRONMENTS; PERFORMANCE; APPEARANCE; FEATURES; LEARN AB The aim of this research is to enhance game-based training applications to support educational events in the absence of live instruction. The overarching purpose of the presented study was to explore available tools for integrating intelligent tutoring communications in game-based learning platforms and to examine theory-based techniques for delivering explicit feedback in such environments. The primary tool influencing the design of this research was the open-source Generalized Intelligent Framework for Tutoring (GIFT), a modular domain-independent architecture that provides the tools and methods to author, deliver, and evaluate intelligent tutoring technologies within any instructional domain. Influenced by research surrounding social cognitive theory and cognitive load theory, the resulting experiment tested varying approaches for utilizing an Embodied Pedagogical Agent (EPA) to function as a tutor during interaction in a game-based training environment. Conditions were authored to assess the trade-offs between embedding an EPA directly in a game, embedding an EPA in GIFT's browser-based Tutor-User Interface (TUI), or using audio prompts alone with no social grounding. The resulting data supported the application of using an EPA embedded in GIFT's TUI to provide explicit feedback during a game-based learning event. Analyses revealed conditions with an EPA situated in the TUI to be as effective as embedding the agent directly in the game environment. Published by Elsevier Ltd. C1 [Goldberg, Benjamin] US Army Res Lab, Orlando, FL 32826 USA. [Cannon-Bowers, Janis] Univ Cent Florida, Inst Simulat & Training, Orlando, FL 32826 USA. RP Goldberg, B (reprint author), US Army Res Lab, 12423 Res Pkwy, Orlando, FL 32826 USA. EM benjamin.s.goldberg.civ@mail.mil; janis.canon-bowers@ucf.edu OI Cannon-Bowers, Janis/0000-0003-2154-4456 FU U.S. Army Research Laboratory - Human Research and Engineering Directorate's (ARL-HRED) Simulation and Training Technology Center (STTC) under the Adaptive Training research program; Engineering Psychology department at the United States Military Academy at West Point FX This research was funded by the U.S. Army Research Laboratory - Human Research and Engineering Directorate's (ARL-HRED) Simulation and Training Technology Center (STTC) under the Adaptive Training research program. We would like to thank the Engineering Psychology department at the United States Military Academy at West Point for supporting this work and assisting with data collection and analysis. NR 55 TC 3 Z9 3 U1 6 U2 44 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0747-5632 EI 1873-7692 J9 COMPUT HUM BEHAV JI Comput. Hum. Behav. PD NOV PY 2015 VL 52 BP 1 EP 11 DI 10.1016/j.chb.2015.05.008 PG 11 WC Psychology, Multidisciplinary; Psychology, Experimental SC Psychology GA CQ9QY UT WOS:000360951200001 ER PT J AU Clayton, JD AF Clayton, J. D. TI Penetration resistance of armor ceramics: Dimensional analysis and property correlations SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Ceramics; Terminal ballistics; Armor; Dimensional analysis ID TUNGSTEN LONG RODS; GRAIN-BOUNDARY PROPERTIES; HIGH-STRAIN RATE; BORON-CARBIDE; BALLISTIC PERFORMANCE; BRITTLE MATERIALS; ALUMINUM NITRIDE; NONLINEAR ELASTICITY; IMPACT VELOCITIES; SILICON-CARBIDE AB A new dimensionless relationship for analysis of ballistic penetration data is derived and applied to polycrystalline ceramic materials. Targets consist of ceramic tiles backed by thick metallic plates within which residual penetration depths have been reported in experimental studies. Particular ceramics analyzed here are low- and high-purity alumina, aluminum nitride, boron carbide, silicon carbide, and titanium diboride. Data for penetration depth versus ceramic tile thickness tend to fall on lines of constant slope regardless of impact velocity, suggesting effects of penetrator velocity and tile thickness may be represented by a separable function of rank two for normalized depth of penetration. The particular relationship developed here contains two material parameters: a length scale and an energy per unit mass. Simultaneous consideration of results of the dimensional analysis and material properties suggest that the length scale, which is related to decreasing penetration depth with increasing tile thickness, correlates with the ratio of surface energy to elastic modulus. The energy per unit mass, which is linked to the relationship between penetration depth and penetrator velocity, correlates with dynamic shear strength of failed ceramic reported from plate impact experiments, divided by mass density. The dimensional analysis provides a structured framework under which future multiscale simulations and validation experiments can be organized and compared. Published by Elsevier Ltd. C1 [Clayton, J. D.] US Army, Impact Phys RDRL WMP C, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Clayton, J. D.] Univ Maryland, Adjunct Fac, A James Clark Sch Engn, College Pk, MD 20742 USA. RP Clayton, JD (reprint author), US Army, Impact Phys RDRL WMP C, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM jdclayt1@umd.edu RI Clayton, John/C-7760-2009 NR 59 TC 3 Z9 4 U1 11 U2 55 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X EI 1879-3509 J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD NOV PY 2015 VL 85 BP 124 EP 131 DI 10.1016/j.ijimpeng.2015.06.025 PG 8 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA CQ3OS UT WOS:000360512600012 ER PT J AU Huskins, EL Cordero, ZC Schuh, CA Schuster, BE AF Huskins, Emily L. Cordero, Zachary C. Schuh, Christopher A. Schuster, Brian E. TI Micropillar compression testing of powders SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID METALLIC-GLASS; SPHERICAL INDENTATION; MECHANICAL-BEHAVIOR; DEFORMATION MODE; LENGTH SCALES; SIZE; STRENGTH; PLASTICITY; BULK; MICROCOMPRESSION AB An experimental design for microcompression on individual powder particles is proposed as a means of testing novel materials without the challenges associated with consolidation to produce bulk specimens. This framework is demonstrated on an amorphous tungsten alloy powder, and yields reproducible measurements of the yield strength (4.5 +/- A 0.3 GPa) and observations of the deformation mode (in this case, serrated flow by shear localization). C1 Army Res Lab, Oak Ridge Inst Sci & Educ, Postdoctoral Fellowship Program, Aberdeen Proving Ground, MD 21005 USA. [Cordero, Zachary C.; Schuh, Christopher A.] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA. [Schuster, Brian E.] Army Res Lab, RDRL WML H, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Schuster, BE (reprint author), Army Res Lab, RDRL WML H, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM brian.e.schuster.civ@mail.mil FU US Defense Threat Reduction Agency [HDTRA1-11-1-0062]; Oak Ridge Institute for Space and Education (ORISE) Program [1120-1120-99]; Department of Defense through the NDSEG fellowship program; [11-24] FX This study was supported by the US Defense Threat Reduction Agency under Grant No. HDTRA1-11-1-0062. ELH acknowledges support through the Oak Ridge Institute for Space and Education (ORISE) Program #1120-1120-99. ZCC gratefully acknowledges support from the Department of Defense through the NDSEG fellowship program. BES would like to acknowledge support work from the Cooperative Research and Development Agreement #11-24. NR 45 TC 1 Z9 1 U1 3 U2 20 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 EI 1573-4803 J9 J MATER SCI JI J. Mater. Sci. PD NOV PY 2015 VL 50 IS 21 BP 7058 EP 7063 DI 10.1007/s10853-015-9260-1 PG 6 WC Materials Science, Multidisciplinary SC Materials Science GA CP3VR UT WOS:000359811300021 ER PT J AU Warnell, G Bhattacharya, S Chellappa, R Basar, T AF Warnell, Garrett Bhattacharya, Sourabh Chellappa, Rama Basar, Tamer TI Adaptive-Rate Compressive Sensing Using Side Information SO IEEE TRANSACTIONS ON IMAGE PROCESSING LA English DT Article DE Compressive sensing; cross validation; opportunistic sensing; background subtraction ID PROJECTIONS; TRACKING; PURSUIT; SIGNALS; SPARSE AB We provide two novel adaptive-rate compressive sensing (CS) strategies for sparse, time-varying signals using side information. The first method uses extra cross-validation measurements, and the second one exploits extra low-resolution measurements. Unlike the majority of current CS techniques, we do not assume that we know an upper bound on the number of significant coefficients that comprises the images in the video sequence. Instead, we use the side information to predict the number of significant coefficients in the signal at the next time instant. We develop our techniques in the specific context of background subtraction using a spatially multiplexing CS camera such as the single-pixel camera. For each image in the video sequence, the proposed techniques specify a fixed number of CS measurements to acquire and adjust this quantity from image to image. We experimentally validate the proposed methods on real surveillance video sequences. C1 [Warnell, Garrett] US Army Res Lab, Adelphi, MD 20783 USA. [Bhattacharya, Sourabh] Iowa State Univ, Dept Mech Engn, Ames, IA 50011 USA. [Chellappa, Rama] Univ Maryland, Ctr Automat Res, Dept Elect & Comp Engn, Inst Adv Comp Studies, College Pk, MD 20742 USA. [Basar, Tamer] Univ Illinois, Dept Elect & Comp Engn, Urbana, IL 61801 USA. RP Warnell, G (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM garrett.a.warnell.civ@mail.mil; sbhattac@iastate.edu; rama@umiacs.umd.edu; basar1@illinois.edu FU U.S. Army Research Laboratory, Adelphi, MD, USA; U.S. Army Research Office, Durham, NC, USA, through the Multidisciplinary University Research Initiative [W911NF-09-1-0383] FX This work was supported in part by the U.S. Army Research Laboratory, Adelphi, MD, USA, and in part by the U.S. Army Research Office, Durham, NC, USA, through the Multidisciplinary University Research Initiative under Grant W911NF-09-1-0383. The associate editor coordinating the review of this manuscript and approving it for publication was Prof. R. Willett. NR 56 TC 4 Z9 4 U1 6 U2 32 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1057-7149 EI 1941-0042 J9 IEEE T IMAGE PROCESS JI IEEE Trans. Image Process. PD NOV PY 2015 VL 24 IS 11 BP 3846 EP 3857 DI 10.1109/TIP.2015.2456425 PG 12 WC Computer Science, Artificial Intelligence; Engineering, Electrical & Electronic SC Computer Science; Engineering GA CO1NV UT WOS:000358923100006 PM 26186780 ER PT J AU Saska, D Blum, RS Kaplan, L AF Saska, David Blum, Rick S. Kaplan, Lance TI Fusion of Quantized and Unquantized Sensor Data for Estimation SO IEEE SIGNAL PROCESSING LETTERS LA English DT Article DE Cramer-Rao bound; parameter estimation; quantization; wireless sensor networks ID DISTRIBUTED DETECTION; CENSORING SENSORS; NETWORKS; FUNDAMENTALS AB This letter investigates the usefulness of quantized data for estimation problems in which unquantized data is already available. A worst case scenario is considered in which a fusion center has access to continuous and binary-valued measurements of the same uniformly distributed parameter observed in Gaussian noise. The difference in mean squared error between a minimum mean squared error estimate using unquantized data and a minimum mean squared error estimate using both quantized and unquantized data is used to quantify the value of fusing the two kinds of data. Discussion of the Cramer-Rao Bound predicts how noise in the quantized data affects the reduction in estimate mean squared error from fusing the data types. It is then determined that the maximum reduction in estimate mean squared error from fusion can be approximated as a rational function of the ratio of the standard deviations of the measurement noise in the two data types. Finally, similarities between the approximation to the reduction in estimate mean squared error for the most favorable uniform prior width and a closed form expression based on the Cramer-Rao Bound are discussed. C1 [Saska, David; Blum, Rick S.] Lehigh Univ, Dept Elect & Comp Engn, Bethlehem, PA 18015 USA. [Kaplan, Lance] Army Res Lab, Adelphi, MD 20783 USA. RP Saska, D (reprint author), Lehigh Univ, Dept Elect & Comp Engn, Bethlehem, PA 18015 USA. EM dzachsaska@gmail.com; rblum@eecs.lehigh.edu; lkaplan@ieee.org FU U.S. Army Research Laboratory; U.S. Army Research Office [W911NF-14-1-0245, W911NF-14-1-0261] FX This work was supported by the U.S. Army Research Laboratory and the U.S. Army Research Office under Grants W911NF-14-1-0245 and W911NF-14-1-0261. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation here on. The associate editor coordinating the review of this manuscript and approving it for publication was Prof. Vincenzo Matta. NR 11 TC 0 Z9 0 U1 2 U2 21 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1070-9908 EI 1558-2361 J9 IEEE SIGNAL PROC LET JI IEEE Signal Process. Lett. PD NOV PY 2015 VL 22 IS 11 BP 1927 EP 1930 DI 10.1109/LSP.2015.2446975 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA CL7BR UT WOS:000357125500001 ER EF