FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Greene, JP Dawson, R AF Greene, Jeffery P. Dawson, Rachel TI School-Based Health Center Model Within the Military Health System: The Role of the Adolescent Medicine Physician SO MILITARY MEDICINE LA English DT Article ID CHILDREN; CARE; ABSENTEEISM; ASTHMA AB Adolescents are less motivated to seek medical care for various reasons. Within the military health care system, access barriers, although less encountered, can still be a burden not only to the adolescent, but also the school system. This article describes the development of a school-based health center within a school district on a military installation. The school clinic was created by adolescent medicine specialists to maximize access to care. Students of adolescent age utilized the clinic for evaluation of acute and chronic conditions, preventative services, preparticipation evaluation, and other general complaints. After receiving signed consent forms, 30% of students were eligible for health care. There was minimal cost to initiate the service. Development of school-based health center programs at other military installations could potentially improve the status of the military health system during a time of high stress among military dependents. C1 [Greene, Jeffery P.] Tripler Army Med Ctr, Dept Pediat, 1 Jarrett White Rd, Honolulu, HI 96859 USA. [Dawson, Rachel] Carl R Darnall Army Med Ctr, Dept Pediat, 36000 Darnall Loop, Ft Hood, TX 76544 USA. RP Greene, JP (reprint author), Tripler Army Med Ctr, Dept Pediat, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 14 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD SEP PY 2016 VL 181 IS 9 BP 1046 EP 1049 DI 10.7205/MILMED-D-15-00346 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA DW5MV UT WOS:000383690500024 PM 27612351 ER PT J AU Deering, SH Kavanagh, LB Chinn, MK Choi, Y Rush, RM Haque, I AF Deering, Shad H. Kavanagh, Laurie B. Chinn, Michael K. Choi, Yong Rush, Robert M., Jr. Haque, Imad TI Objective Evaluation of the Effects of Deployment on Laparoscopic Skills: The Simulation and Deployment Laparoscopic Skills Study SO MILITARY MEDICINE LA English DT Article AB Objective: To assess the effects of deployment on basic laparoscopic skills of general surgeons and obstetrics/gynecology (OB/GYN) physicians. Methods: This was a prospective 10-site study. Active duty Army OB/GYN and general surgery physicians scheduled to deploy were invited to participate. Before deployment, they performed fundamentals of laparoscopic surgery (FLS) tasks and specialty-specific procedures on a virtual reality laparoscopic simulator. Upon returning, physicians repeated the same evaluations. Questions about perceived comfort with laparoscopic procedures were asked before and after deployment. Statistical analysis included paired t tests for continuous variables and nonparametric for ordinal data with a p value of <0.05 considered significant. Results: 121 deploying providers were invited to participate; 35 agreed and 29 completed the predeployment skills assessment. After deployment, 15 providers had postassessment evaluation data collected, and their results were used for analysis. Though physicians reported a decrease in their perception of preparedness for advanced laparoscopic procedures and complications, there was no decrement in their performance of FLS tasks or the basic laparoscopic procedures. Conclusion: Time away from regular clinical practice during deployments did not significantly affect surgeons' performance as measured by a virtual reality laparoscopic simulator. Additional study on effects on advanced procedures should be considered. C1 [Deering, Shad H.] Uniformed Serv Univ Hlth Sci, 4301 Jones Bridge Rd, Bethesda, MD 20889 USA. [Kavanagh, Laurie B.; Haque, Imad] Madigan Army Med Ctr, Andersen Simulat Ctr, 9040 Jackson Ave, Tacoma, WA 98431 USA. [Chinn, Michael K.] Madigan Army Med Ctr, Dept OB GYN, Tacoma, WA 98431 USA. [Choi, Yong] Eisenhower Army Med Ctr, Dept Minimally Invas & Bariatr Surg, Ft Gordon, GA 30905 USA. [Rush, Robert M., Jr.] Madigan Army Med Ctr, Dept Gen Surg, Tacoma, WA 98431 USA. RP Deering, SH (reprint author), Uniformed Serv Univ Hlth Sci, 4301 Jones Bridge Rd, Bethesda, MD 20889 USA. FU Joint Program Committee for Medical Simulation (JPC-1), Fort Detrick, Maryland FX A project of this magnitude cannot be done by anything less than a motivated and dedicated team. We would like to acknowledge all of the site coordinators and site primary investigators, without whom none of this would have been possible. The team includes Ruth Andrews, MAJ Ernest Alexander, COL Paul Brisson, COL Tommy Brown, Dr. Samuel Cancel-Rivera, COL Michael Chinn, COL Yong Choi, Robert Coffman, LTC James Dickerson, MAJ Claire Gould, LTC(P) Bret Guidry, LTC Imad Haque, COL Edmund Higgins, Thomas Kai, LCDR John Lydon, LTC Rebecca McGuigan, MAJ Brandi McLeod, Michelle Martinez, LTC Jeff Mikita, MAJ Jacqueline Moore, Mike Morton, COL Peter Nielsen, Leonel Ortega, T. (Phil) Phillips, Roy Ridgeway, Tahir Ruffin, John Rogers, Danny Rodriguez, COL Robert Rush, Ray Sanders, Charles Steiner, MAJ Joseph Sterbis, Sunny Yauger, and Mark Wyn. Funding for this study was provided by the Joint Program Committee for Medical Simulation (JPC-1), Fort Detrick, Maryland. NR 5 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD SEP PY 2016 VL 181 IS 9 BP 1058 EP 1064 DI 10.7205/MILMED-D-15-00265 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA DW5MV UT WOS:000383690500026 PM 27612353 ER PT J AU Sauers, SE Smith, LB Scofield, DE Cooper, A Warr, BJ AF Sauers, Sarah E. Smith, Laurel B. Scofield, Dennis E. Cooper, Adam Warr, Bradley J. TI Self-Management of Unreported Musculoskeletal Injuries in a US Army Brigade SO MILITARY MEDICINE LA English DT Article ID NONSTEROIDAL ANTIINFLAMMATORY DRUGS; SKELETAL-MUSCLE; MILITARY PERSONNEL; IRAQI FREEDOM; SOLDIERS; PAIN; RECOMMENDATIONS; SURVEILLANCE; EXERCISE; COSTS AB Background: There is a paucity of literature describing the accuracy of musculoskeletal injury reporting in the U.S. Army. Purpose: To investigate symptom-management behaviors as well as factors associated with seeking medical treatment among active duty Soldiers who reported that they had concealed at least one musculoskeletal injury. Methods: Anonymous surveys were completed by Soldiers (N = 1,388; 1,269 males, 74 females, and 45 no response) assigned to an Infantry Brigade Combat Team. Soldiers were asked to self-report injuries sustained in the last 12 months and whether or not they reported those injuries to a medical provider. Descriptive statistics were used to analyze treatment alternatives. Chi-square test was used to assess any significant relationships between injury and various demographics. Results: There were 808 (58%) Soldiers who stated they had an injury that they did not report. Over-the-counter pain relief medication (81%) was the most commonly selected alternative treatment. Conclusion: Over-the-counter pain medication was frequently used for symptom management among Soldiers who did not report their injury to a medical provider. C1 [Sauers, Sarah E.; Smith, Laurel B.; Scofield, Dennis E.; Cooper, Adam; Warr, Bradley J.] US Army, Environm Med Res Inst, Mil Performance Div, 10 Gen Greene Ave,Bldg 42, Natick, MA 01760 USA. RP Sauers, SE (reprint author), US Army, Environm Med Res Inst, Mil Performance Div, 10 Gen Greene Ave,Bldg 42, Natick, MA 01760 USA. NR 30 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD SEP PY 2016 VL 181 IS 9 BP 1075 EP 1080 DI 10.7205/MILMED-D-15-00233 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA DW5MV UT WOS:000383690500029 PM 27612356 ER PT J AU Lannan, FM O'conor, DK Broderick, JC Tate, JF Scoggin, JT Moran, NA Husson, CM Hegeman, EM Ogrydziak, CE Singh, SA Vafides, AG Brinkley, CC Goodin, JL AF Lannan, Ford M. O'conor, Daniel K. Broderick, Joseph C. Tate, Jamison F. Scoggin, Jacob T. Moran, Nicholas A. Husson, Christopher M. Hegeman, Erik M. Ogrydziak, Cole E. Singh, Sneha A. Vafides, Andrew G. Brinkley, Carl C. Goodin, Jeremy L. TI Evaluation of Virulence Gene Expression Patterns in Acinetobacter baumannii Using Quantitative Real-Time Polymerase Chain Reaction Array SO MILITARY MEDICINE LA English DT Article ID BIOFILM FORMATION; OPPORTUNISTIC PATHOGEN; INFECTIONS; SURFACES; COLISTIN; SYSTEM; INVOLVEMENT; MILITARY; OUTBREAK; SURVIVAL AB According to the Centers for Disease Control's recently devised National Strategy for Combating Antibiotic-Resistant Bacteria, Acinetobacter baumannii is a "serious" threat level pathogen. A. baumannii's notoriety stems from the fact that a large number of modern strains are multidrug resistant and persist in the hospital setting, thus causing numerous deaths per year. It is imperative that research focus on a more fundamental understanding of the factors responsible for the success of A. baumannii. Toward this end, our group investigated virulence gene expression patterns in a recently characterized wound isolate, AB5075, using quantitative real-time polymerase chain reaction array. Notably, several genes showed statistically significant upregulation at 37 degrees C compared to 25 degrees C; MviM, Wbbj, CarO, and certain genes of the Bas, Bar, and Csu operons. Additionally, we found that in vitro biofilm formation by Csu transposon insertion mutant strains is attenuated. These findings validate previous reports that suggest a link between the Csu operon and biofilm formation. More importantly, our results demonstrate a successful method for evaluating the significance of previously identified virulence factors in a modern and clinically relevant strain of A. baumannii, thereby providing a path toward a more fundamental understanding of the pathogenicity of A. baumannii. C1 [Lannan, Ford M.; O'conor, Daniel K.; Broderick, Joseph C.; Tate, Jamison F.; Scoggin, Jacob T.; Moran, Nicholas A.; Husson, Christopher M.; Hegeman, Erik M.; Ogrydziak, Cole E.; Singh, Sneha A.; Vafides, Andrew G.; Brinkley, Carl C.; Goodin, Jeremy L.] US Mil Acad, Dept Chem & Life Sci, 646 Swift Rd, West Point, NY 10996 USA. RP Lannan, FM (reprint author), US Mil Acad, Dept Chem & Life Sci, 646 Swift Rd, West Point, NY 10996 USA. NR 33 TC 0 Z9 0 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD SEP PY 2016 VL 181 IS 9 BP 1108 EP 1113 DI 10.7205/MILMED-D-15-00437 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA DW5MV UT WOS:000383690500034 PM 27612361 ER PT J AU Barringer, ND Kotwal, RS Lewis, MD Funderburk, LK Elliott, TR Crouse, SF Smith, SB Greenwood, M Kreider, RB AF Barringer, Nicholas D. Kotwal, Russ S. Lewis, Michael D. Funderburk, Leslee K. Elliott, Timothy R. Crouse, Stephen F. Smith, Stephen B. Greenwood, Michael Kreider, Richard B. TI Fatty Acid Blood Levels, Vitamin D Status, Physical Performance, Activity, and Resiliency: A Novel Potential Screening Tool for Depressed Mood in Active Duty Soldiers SO MILITARY MEDICINE LA English DT Article ID OMEGA-3 INDEX; RISK-FACTOR; MILITARY; SYMPTOMS; US; HARDINESS; SUICIDE; COMBAT; DISEASE; PTSD AB This study examined whether blood fatty acid levels, vitamin D status, and/or physical activity are associated with physical fitness scores; a measure of mood, Patient Health Questionnaire-9; and a measure of resiliency, Dispositional Resiliency Scale-15 in active duty Soldiers. 100 active duty males at Fort Hood, Texas, underwent a battery of psychometric tests, anthropometric measurements, and fitness tests, and they also provided fasting blood samples for fatty acid and vitamin D analysis. Pearson bivariate correlation analysis revealed significant correlations among psychometric tests, anthropometric measurements, physical performance, reported physical inactivity (sitting time), and fatty acid and vitamin D blood levels. On the basis of these findings, a regression equation was developed to predict a depressed mood status as determined by the Patient Health Questionnaire-9. The equation accurately predicted depressed mood status in 80% of our participants with a sensitivity of 76.9% and a specificity of 80.5%. Results indicate that the use of a regression equation may be helpful in identifying Soldiers at higher risk for mental health issues. Future studies should evaluate the impact of exercise and diet as a means of improving resiliency and reducing depressed mood in Soldiers. C1 [Barringer, Nicholas D.; Funderburk, Leslee K.] US Military Baylor Univ, Grad Program Nutr, Army Med Dept Ctr & Sch, 3630 Stanley Rd,Bldg 2841 Suite 0303, Jbsa Ft Sam Houston, TX 78234 USA. [Kotwal, Russ S.] US Army Inst Surg Res, Joint Trauma Syst, 3698 Chambers Pass Suite B, Jbsa Ft Sam Houston, TX 78234 USA. [Lewis, Michael D.] Brain Hlth Educ & Res Inst, POB 61052, Potomac, MD 20854 USA. [Elliott, Timothy R.] Texas A&M Univ, Dept Educ Psychol, 4225 TAMU, College Stn, TX 77843 USA. [Crouse, Stephen F.] Texas A&M Univ, Dept Hlth & Kinesiol, Appl Exercise Sci Lab, 4243 TAMU, College Stn, TX 77843 USA. [Smith, Stephen B.] Texas A&M Univ, Dept Nutr & Food Sci, 2253 TAMU, College Stn, TX 77843 USA. [Greenwood, Michael; Kreider, Richard B.] Texas A&M Univ, Exercise & Sport Nutr Lab, Dept Hlth & Kinesiol, 1700 Res Pkwy,Bldg 2,Suite 2500, College Stn, TX 77843 USA. RP Barringer, ND (reprint author), US Military Baylor Univ, Grad Program Nutr, Army Med Dept Ctr & Sch, 3630 Stanley Rd,Bldg 2841 Suite 0303, Jbsa Ft Sam Houston, TX 78234 USA. RI Elliott, Timothy/I-5301-2012 OI Elliott, Timothy/0000-0002-6608-7714 NR 33 TC 0 Z9 0 U1 3 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD SEP PY 2016 VL 181 IS 9 BP 1114 EP 1120 DI 10.7205/MILMED-D-15-00456 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA DW5MV UT WOS:000383690500035 PM 27612362 ER PT J AU Lynch, JH Mulvaney, SW Kim, EH de Leeuw, JB Schroeder, MJ Kane, SF AF Lynch, James H. Mulvaney, Sean W. Kim, Eugene H. de Leeuw, Jason B. Schroeder, Matthew J. Kane, Shawn F. TI Effect of Stellate Ganglion Block on Specific Symptom Clusters for Treatment of Post-Traumatic Stress Disorder SO MILITARY MEDICINE LA English DT Article ID MENTAL-HEALTH PROBLEMS; CASE SERIES; FOLLOW-UP; COMBAT; PTSD; IRAQ; METAANALYSIS; AFGHANISTAN; CHECKLIST; CARE AB This study assessed which symptoms are most impacted following stellate ganglion block (SGB) used to treat post-traumatic stress disorder (PTSD) symptoms. 30 active military service members with combat-related PTSD self-referred to their physician and psychologist. Patients were offered a SGB as part of their treatment program. Primary outcome was the magnitude of change for the 17 items on the PTSD Checklist-Military (PCL-M), which was administered the week before SGB, 1 week after SGB, and 2 to 4 months later. Mean PCL-M score decreased from 49 at baseline to 32, 1 week after the procedure (p < 0.001). 2 to 4 months after SGB, patients maintained an average PCL-M of 32. Patients reported greatest improvement in the first week after SGB for the following symptoms: irritability or angry outbursts, difficulty concentrating, and sleep disturbance. 2 to 4 months later, patients reported greatest improvement in the following: feeling distant or cut off, feeling emotionally numb, irritability or angry outbursts, and difficulty concentrating. SGB is a safe procedure that may provide extended relief for all clusters of PTSD symptoms. As a result of the significant reduction in hyperarousal and avoidance symptoms observed, this study supports incorporation of SGB into PTSD treatment plans. C1 [Lynch, James H.] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. [Mulvaney, Sean W.] Ft Belvoir Community Hosp, Dept Phys Med & Rehabil, 9300 Dewitt Loop, Ft Belvoir, VA 22060 USA. [Kim, Eugene H.] Womack Army Med Ctr, Dept Behav Hlth, 4817 Reilly Rd, Ft Bragg, NC 28310 USA. [de Leeuw, Jason B.] 902d Mil Intelligence Grp, 2600 Ernie Pyle St, Ft George G Meade, MD 20755 USA. [Schroeder, Matthew J.] Uniformed Serv Univ Hlth Sci, Consortium Hlth & Mil Performance, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. [Kane, Shawn F.] US Army, Special Operat Command, 2929 Desert Storm Dr, Ft Bragg, NC 28310 USA. RP Lynch, JH (reprint author), Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. NR 34 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD SEP PY 2016 VL 181 IS 9 BP 1135 EP 1141 DI 10.7205/MILMED-D-15-00518 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA DW5MV UT WOS:000383690500038 PM 27612365 ER PT J AU Charkoudian, N Kenefick, RW Lapadula, AJ Swiston, AJ Patel, T Blanchard, LA Caruso, EM Luippold, AJ Cheuvront, SN AF Charkoudian, Nisha Kenefick, Robert W. Lapadula, Anthony J. Swiston, Albert J. Patel, Tajesh Blanchard, Laurie A. Caruso, Elizabeth M. Luippold, Anthony J. Cheuvront, Samuel N. TI Planning Military Drinking Water Needs: Development of a User-Friendly Smart Device Application SO MILITARY MEDICINE LA English DT Article ID SWEAT LOSS; PREDICTION EQUATIONS; AEROBIC PERFORMANCE; HEAT-STRESS; HOT WEATHER; EXERCISE; HYPOHYDRATION AB Potable water is essential to maintain health and sustain military operations, but carrying and transporting water is a major logistical burden. Planning for group drinking water needs is complex, requiring understanding of sweat losses on the basis of intensity of activity, clothing biophysical parameters, and environmental conditions. Use of existing prediction equations is limited to tabled doctrine (e.g., Technical Bulletin, Medical 507) or to individuals with extensive expertise in thermal biophysics. In the present project, we translated the latest updated equations into a user-friendly Android application (Soldier Water Estimation Tool, SWET) that provides estimated drinking water required from 5 simple inputs based upon a detailed multiparametric sensitivity analysis. Users select from multiple choice inputs for activity level, clothing, and cloud cover, and manually enter exact values for temperature and relative humidity. Total drinking water needs for a unit are estimated in the Mission Planner tool on the basis of mission duration and number of personnel. In preliminary user acceptability testing, responses were overall positive in terms of ease of use and military relevance. Use of SWET for water planning will minimize excessive load (water) carriage in training and mission settings, and will reduce the potential for dehydration and/or hyponatremia to impair Warfighter health and performance. C1 [Charkoudian, Nisha; Kenefick, Robert W.; Caruso, Elizabeth M.; Luippold, Anthony J.; Cheuvront, Samuel N.] US Army Res Inst Environm Med, Thermal & Mt Med Div, Gen Greene Ave, Natick, MA 01760 USA. [Lapadula, Anthony J.; Swiston, Albert J.; Patel, Tajesh] MIT, Lincoln Lab, 244 Wood St, Lexington, MA 02420 USA. [Blanchard, Laurie A.] US Army Res Inst Environm Med, Biophys & Biomed Modeling Div, Gen Greene Ave, Natick, MA 01760 USA. RP Charkoudian, N (reprint author), US Army Res Inst Environm Med, Thermal & Mt Med Div, Gen Greene Ave, Natick, MA 01760 USA. FU U.S. Army Medical Research and Materiel Command Military Operational Medicine Research Program FX We gratefully acknowledge Dr. Richard R. Gonzalez for his central work in developing the algorithm that was the basis for the development of SWET, and for his important input and suggestions in the development of the app. Development of the models to predict water loss and hydration requirements, as well as the transition of these models into specific smartphone app development, have been supported by U.S. Army Medical Research and Materiel Command Military Operational Medicine Research Program (Task Area 10, Hot Weather Operations and Hydration: Injury and Performance Optimization). NR 23 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD SEP PY 2016 VL 181 IS 9 BP 1142 EP 1150 DI 10.7205/MILMED-D-15-00291 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA DW5MV UT WOS:000383690500039 PM 27612366 ER PT J AU DiNicola, AF DiNicola, PJ Sanchez, L AF DiNicola, Albert F. DiNicola, Peter J. Sanchez, Lucia TI Need for Routine Vitamin D Screening in Military Personnel SO MILITARY MEDICINE LA English DT Letter C1 [DiNicola, Albert F.; DiNicola, Peter J.] US Army, Inst Surg Res, 3698 Chambers Rd, San Antonio, TX 78234 USA. [Sanchez, Lucia] Brooke Army Med Ctr, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA. RP DiNicola, AF (reprint author), US Army, Inst Surg Res, 3698 Chambers Rd, San Antonio, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD SEP PY 2016 VL 181 IS 9 BP 1163 EP 1164 DI 10.7205/MILMED-D-16-00115 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA DW5MV UT WOS:000383690500043 PM 27612370 ER PT J AU Stinner, DJ Wise, JS AF Stinner, Daniel J. Wise, Jessica S. TI Maintaining Military Readiness: Should the Way We Train Change? SO MILITARY MEDICINE LA English DT Letter C1 [Stinner, Daniel J.] US Army, Inst Surg Res, 3698 Chambers Rd, San Antonio, TX 78234 USA. [Wise, Jessica S.] Brooke Army Med Ctr, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA. RP Stinner, DJ (reprint author), US Army, Inst Surg Res, 3698 Chambers Rd, San Antonio, TX 78234 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD SEP PY 2016 VL 181 IS 9 BP 1163 EP 1163 DI 10.7205/MILMED-D-16-00057 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA DW5MV UT WOS:000383690500042 PM 27612369 ER PT J AU Magee, CD Witte, S Kwok, RM Deuster, PA AF Magee, Charles D. Witte, Stephen Kwok, Ryan M. Deuster, Patricia A. TI Mission Compromised? Drug-Induced Liver Injury From Prohormone Supplements Containing Anabolic-Androgenic Steroids in Two Deployed US Service Members SO MILITARY MEDICINE LA English DT Article ID CAUSALITY ASSESSMENT; DIETARY-SUPPLEMENTS; ADVERSE REACTIONS; PUBLIC-HEALTH; RISK AB Background: Supplement adulteration with anabolic-androgenic steroids (AAS) has been reported and AAS-associated drug-induced liver injury is clinically variable. Objectives: We present two cases of AAS-associated drug-induced liver injury in deployed service members, including the first report of clinical hepatotoxicity with desoxymethyltestosterone. We highlight variable hepatotoxicity patterns of AAS, raise concern with inaccurate supplement labeling and identify educational resources. Methods: The first case presents with cholestatic jaundice following 10 weeks of prohormone use. Hepatobiliary imaging was unrevealing. Viral, autoimmune, and metabolic etiologies were excluded. Bilirubin normalized by 8 weeks after stopping the supplement. The second case presents with asymptomatic hepatocellular toxicity and marked dyslipidemia identified on service-related physical following 21 days of prohormone use. Aspartate aminotransferase and alanine aminotransferase normalized 4 weeks after supplement cessation; high-density lipoprotein and low-density lipoprotein returned to baseline at 8 weeks. Each supplement was volunteered for analytic testing. Results: Supplement label contents did not match gas chromatography/mass spectrometry analysis; 3 of 4 supplements contained federally regulated AAS. Conclusions: AAS hepatotoxicity is clinically variable and dyslipidemia may be an important clinical indicator. False labeling introduces clinical risk and threatens mission readiness. Educational resources are available to facilitate information sharing. Supplement analysis informs of clinical risk of specific supplements and facilitates shared clinical decision-making. C1 [Magee, Charles D.] Uniformed Serv Univ Hlth Sci, Dept Med, Div Mil Internal Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. [Witte, Stephen] Robinson Hlth Clin, 1722 Tagayta Dr, Ft Bragg, NC 28310 USA. [Kwok, Ryan M.] Walter Reed Natl Mil Med Ctr, Dept Gastroenterol, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. [Deuster, Patricia A.] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. RP Magee, CD (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med, Div Mil Internal Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. NR 15 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD SEP PY 2016 VL 181 IS 9 BP E1169 EP E1171 DI 10.7205/MILMED-D-15-00502 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA DW5MV UT WOS:000383690500001 PM 27612377 ER PT J AU Singamaneni, SR Prater, JT Wu, F Narayan, J AF Singamaneni, Srinivasa Rao Prater, J. T. Wu, Fan Narayan, J. TI Ferromagnetic oxide heterostructures on silicon SO MRS Communications LA English DT Article ID SRRUO3 THIN-FILMS; EXCHANGE BIAS; INTERFACE; SUPERLATTICES; MAGNETISM; BILAYERS; EPITAXY; PHYSICS; SRTIO3 AB Heterostructures consisting of two ferromagnetic oxides La0.7Ca0.3MnO3 (LCMO) and SrRuO3 (SRO) were epitaxially grown by pulsed laser deposition onto a silicon (Si) substrate buffered by SrTiO3 (STO)/MgO/TiN. The x-ray scans and electron-diffraction patterns reveal the epitaxial nature of all five layers. From transmission electron microscopy, the thicknesses of the LCMO and SRO layers were estimated to be similar to 100 and similar to 200 nm, respectively. The magnetic properties of individual SRO and LCMO layers are in good agreement with the previous studies reported for those individual layers deposited on lattice-matched substrates, such as STO. The LCMO/SRO heterostructures showed enhanced switching field (from 6008 to 7600 Oe), which may originate from the bulk part of the heterostructure. The ability to grow these multifunctional structures on Si provides a route for wafer scale integration with Si, in contrast to oxide substrates that are not suitable for CMOS integration for microelectronics and spintronics applications. C1 [Singamaneni, Srinivasa Rao; Prater, J. T.] Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. [Singamaneni, Srinivasa Rao; Prater, J. T.; Wu, Fan; Narayan, J.] North Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Singamaneni, Srinivasa Rao] Univ Texas El Paso, Dept Phys, El Paso, TX 79968 USA. [Wu, Fan] Princeton Univ, Princeton Inst Sci & Technol Mat PRISM, 70 Prospect Ave, Princeton, NJ 08540 USA. RP Singamaneni, SR (reprint author), Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA.; Singamaneni, SR (reprint author), North Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA.; Singamaneni, SR (reprint author), Univ Texas El Paso, Dept Phys, El Paso, TX 79968 USA. EM ssingam@ncsu.edu FU National Academy of Science (NAS), USA; Army Research Office [W911NF-04-D-0003] FX S.S.R. acknowledges National Academy of Science (NAS), USA for awarding the NRC postdoctoral research associate fellowship. The authors are pleased to acknowledge the support of the Army Research Office under Grant W911NF-04-D-0003. Also, the authors acknowledge the use of the Analytical Instrumentation Facility (AIF) at North Carolina State University, which is supported by the State of North Carolina and the National Science Foundation. NR 33 TC 1 Z9 1 U1 8 U2 8 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 2159-6859 EI 2159-6867 J9 MRS COMMUN JI MRS Commun. PD SEP PY 2016 VL 6 IS 3 BP 234 EP 240 DI 10.1557/mrc.2016.22 PG 7 WC Materials Science, Multidisciplinary SC Materials Science GA ED8RA UT WOS:000389137400012 ER PT J AU Strazzo, SE Elsner, JB LaRow, TE Murakami, H Wehner, M Zhao, M AF Strazzo, S. E. Elsner, J. B. LaRow, T. E. Murakami, H. Wehner, M. Zhao, M. TI The influence of model resolution on the simulated sensitivity of North Atlantic tropical cyclone maximum intensity to sea surface temperature SO JOURNAL OF ADVANCES IN MODELING EARTH SYSTEMS LA English DT Article DE tropical cyclones; climate models ID CLIMATE SIMULATIONS; HURRICANE INTENSITY; CUMULUS CONVECTION; PARAMETERIZATION; SST; VARIABILITY; PREDICTION; DEPENDENCE; INCREASE; IMPACTS AB Global climate models (GCMs) are routinely relied upon to study the possible impacts of climate change on a wide range of meteorological phenomena, including tropical cyclones (TCs). Previous studies addressed whether GCMs are capable of reproducing observed TC frequency and intensity distributions. This research builds upon earlier studies by examining how well GCMs capture the physically relevant relationship between TC intensity and SST. Specifically, the influence of model resolution on the ability of a GCM to reproduce the sensitivity of simulated TC intensity to SST is examined for the MRI-AGCM (20 km), the GFDL-HiRAM (50 km), the FSU-COAPS (0.94 degrees) model, and two versions of the CAM5 (1 degrees and 0.25 degrees). Results indicate that while a 1 degrees C increase in SST corresponds to a 5.5-7.0 m s(-1) increase in observed maximum intensity, the same 1 degrees C increase in SST is not associated with a statistically significant increase in simulated TC maximum intensity for any of the models examined. However, it also is shown that the GCMs all capably reproduce the observed sensitivity of potential intensity to SST. The models generate the thermodynamic environment suitable for the development of strong TCs over the correct portions of the North Atlantic basin, but strong simulated TCs do not develop over these areas, even for models that permit Category 5 TCs. This result supports the notion that direct simulation of TC eyewall convection is necessary to accurately represent TC intensity and intensification processes in climate models, although additional explanations are also explored. C1 [Strazzo, S. E.; Elsner, J. B.] Florida State Univ, Dept Geog, Tallahassee, FL 32306 USA. [Strazzo, S. E.] US Mil Acad, Dept Geog & Environm Engn, West Point, NY 10996 USA. [LaRow, T. E.] Verato Inc, Mclean, VA USA. [Murakami, H.; Zhao, M.] NOAA Geophys Fluid Dynam Lab, Princeton, NJ USA. [Wehner, M.] Lawrence Berkeley Natl Lab, Berkeley, CA USA. [Murakami, H.] Meteorol Res Inst, Tsukuba, Ibaraki, Japan. RP Strazzo, SE (reprint author), Florida State Univ, Dept Geog, Tallahassee, FL 32306 USA.; Strazzo, SE (reprint author), US Mil Acad, Dept Geog & Environm Engn, West Point, NY 10996 USA. EM s.e.strazz@gmail.com FU Risk Prediction Initiative (RPI) of the Bermuda Institute of Ocean Sciences (BIOS); program "Projection of the Change in Future Weather Extremes Using Super-High-Resolution Atmospheric Models'' - KAKUSHIN program of Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan; program "Projection of the Change in Future Weather Extremes Using Super-High-Resolution Atmospheric Models'' - SOUSEI program of Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan; U.S. Department of Energy Office of Science; NOAA Climate Program Office; Regional and Global Climate Modeling Program of the Office of Biological and Environmental Research in the Department of Energy Office of Science [DE-AC02-05CH11231] FX We are grateful for the constructive feedback Jim Kossin and two anonymous reviewers provided during the review of this paper. We also thank Baoqiang Xiang for comments and suggestions provided during a NOAA internal review. JBE was supported by a grant from the Risk Prediction Initiative (RPI) of the Bermuda Institute of Ocean Sciences (BIOS). HM was supported by the program "Projection of the Change in Future Weather Extremes Using Super-High-Resolution Atmospheric Models'' funded by the KAKUSHIN and SOUSEI programs of the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan. Calculations by the MRI-AGCM3.2 were performed on the Earth Simulator. TEL received grant support from the U.S. Department of Energy Office of Science and the NOAA Climate Program Office. MW was supported by the Regional and Global Climate Modeling Program of the Office of Biological and Environmental Research in the Department of Energy Office of Science under contract DE-AC02-05CH11231. Observed tropical cyclone data used in this paper were obtained from http://www.nhc.noaa.gov/data/#hurdat, and the code used to interpolate the TC data can be found at http://www.hurricaneclimate.com/. SST data were downloaded from http://www.metoffice.gov.uk/hadobs/hadisst/data/download.html, and MERRA reanalysis data were downloaded from http://disc.sci.gsfc.nasa.gov/mdisc/data-holdings/merra/merra_products_n onjs.shtml. Simulated TC track data are available upon request. The code used to generate these results is available at http://rpubs.com/sestrazz/modelRes. NR 59 TC 0 Z9 0 U1 2 U2 2 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 1942-2466 J9 J ADV MODEL EARTH SY JI J. Adv. Model. Earth Syst. PD SEP PY 2016 VL 8 IS 3 BP 1037 EP 1054 DI 10.1002/2016MS000635 PG 18 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA EC0LV UT WOS:000387793500001 ER PT J AU Person, R AF Person, Robert TI The Deep Impact of Economic Collapse on Democratic Support SO PROBLEMS OF POST-COMMUNISM LA English DT Article ID POLITICAL CONTEXT; INFERENCE; JUDGMENTS; GERMANY; REFORM; TRANSITION; ELECTIONS; REVISION; OUTCOMES; BELIEFS AB What is democracy? To many citizens of post-Soviet countries it is synonymous with the disorder, instability, chaos, and hardship that was widespread throughout the 1990s. Importantly, these beliefs have been remarkably durable despite the subsequent economic recovery. While strong majorities remain supportive of democracy, the dynamics of transition have resulted in a subpopulation that is quite skeptical of democracy's ability to deliver on its promises, a fact that has important implications for future regime development in these countries. The present article combines qualitative interview data and nationally-representative surveys of Russia, Belarus, Ukraine, and Latvia to explore the long-term consequences of economic collapse on beliefs about democracy and dictatorship among citizens of the post-Soviet states. C1 [Person, Robert] US Mil Acad, Dept Social Sci, 607 Cullum Rd, West Point, NY 10996 USA. RP Person, R (reprint author), US Mil Acad, Dept Social Sci, 607 Cullum Rd, West Point, NY 10996 USA. EM robert.person@usma.edu FU National Science Foundation; Fulbright Hays Program; Yale MacMillan Center for International and Area Studies FX I am grateful to the National Science Foundation, the Fulbright Hays Program, and the Yale MacMillan Center for International and Area Studies for their support of this research. NR 120 TC 0 Z9 0 U1 6 U2 6 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1075-8216 EI 1557-783X J9 PROBL POST-COMMUNISM JI Probl. Post-Communism PD SEP-DEC PY 2016 VL 63 IS 5-6 SI SI BP 335 EP 353 DI 10.1080/10758216.2016.1148451 PG 19 WC Political Science SC Government & Law GA ED3GN UT WOS:000388737700007 ER PT J AU Schlussel, AT Delaney, CP Maykel, JA Lustik, MB Nishtala, M Steele, SR AF Schlussel, Andrew T. Delaney, Conor P. Maykel, Justin A. Lustik, Michael B. Nishtala, Madhuri Steele, Scott R. TI A National Database Analysis Comparing the Nationwide Inpatient Sample and American College of Surgeons National Surgical Quality Improvement Program in Laparoscopic vs Open Colectomies: Inherent Variance May Impact Outcomes SO DISEASES OF THE COLON & RECTUM LA English DT Article DE Nationwide Inpatient Sample; National Surgical Quality Improvement Program; Population data; Colectomy; Outcomes; Laparoscopy ID SUBTOTAL COLECTOMY; CLINICAL REGISTRY; CANCER RESECTION; CLAIMS DATA; COLON; COLITIS AB BACKGROUND: Clinical and administrative databases each have fundamental distinctions and inherent limitations that may impact results. OBJECTIVE: This study aimed to compare the American College of Surgeons National Surgical Quality Improvement Program and the Nationwide Inpatient Sample, focusing on the similarities, differences, and limitations of both data sets. DESIGN: All elective open and laparoscopic segmental colectomies from American College of Surgeons National Surgical Quality Improvement Program (2006-2013) and Nationwide Inpatient Sample (2006-2012) were reviewed. International Classification of Diseases, Ninth Revision, Clinical Modification coding identified Nationwide Inpatient Sample cases, and Current Procedural Terminology coding for American College of Surgeons National Surgical Quality Improvement Program. Common demographics and comorbidities were identified, and in-hospital outcomes were evaluated. SETTINGS: A national sample was extracted from population databases. PATIENTS: Data were derived from the Nationwide Inpatient Sample database: 188,326 cases (laparoscopic = 67,245; open = 121,081); and American College of Surgeons National Surgical Quality Improvement Program: 110,666 cases (laparoscopic = 54,191; open = 56,475). MAIN OUTCOME MEASURES: Colectomy data were used as an avenue to compare differences in patient characteristics and outcomes between these 2 data sets. RESULTS: Laparoscopic colectomy demonstrated superior outcomes compared with open; therefore, results focused on comparing a minimally invasive approach among the data sets. Because of sample size, many variables were statistically different without clinical relevance. Coding discrepancies were demonstrated in the rate of conversion from laparoscopic to open identified in the National Surgical Quality Improvement Program (3%) and Nationwide Inpatient Sample (15%) data sets. The prevalence of nonmorbid obesity and anemia from National Surgical Quality Improvement Program was more than twice that of Nationwide Inpatient Sample. Sepsis was statistically greater in National Surgical Quality Improvement Program, with urinary tract infections and acute kidney injury having a greater frequency in the Nationwide Inpatient Sample cohort. Surgical site infections were higher in National Surgical Quality Improvement Program (30-day) vs Nationwide Inpatient Sample (8.4% vs 2.6%; p < 0.01), albeit less when restricted to infections that occurred before discharge (3.3% vs 2.6%; p < 0.01). LIMITATIONS: This is a retrospective study using population-based data. CONCLUSION: This analysis of 2 large national databases regarding colectomy outcomes highlights the incidence of previously unrecognized data variability. These discrepancies can impact study results and subsequent conclusions/recommendations. These findings underscore the importance of carefully choosing and understanding the different population-based data sets before designing and when interpreting outcomes research. C1 [Schlussel, Andrew T.; Maykel, Justin A.] Univ Massachusetts, Div Colorectal Surg, Mem Med Ctr, Worcester, MA 01605 USA. [Delaney, Conor P.] Cleveland Clin, Inst Digest Dis, Cleveland, OH 44106 USA. [Lustik, Michael B.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI USA. [Nishtala, Madhuri; Steele, Scott R.] Univ Hosp Case Med Ctr, Div Colorectal Surg, Cleveland, OH USA. RP Steele, SR (reprint author), Case Western Reserve Univ, Div Colorectal Surg, Univ Hosp Case Med Ctr, 11100 Euclid Ave, Cleveland, OH 44106 USA. EM harkersteele@mac.com NR 27 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0012-3706 EI 1530-0358 J9 DIS COLON RECTUM JI Dis. Colon Rectum PD SEP PY 2016 VL 59 IS 9 BP 843 EP 854 DI 10.1097/DCR.0000000000000642 PG 12 WC Gastroenterology & Hepatology; Surgery SC Gastroenterology & Hepatology; Surgery GA EC8EP UT WOS:000388373600006 PM 27505113 ER PT J AU Caldwell, NW Guymon, CH Aden, JK Akers, KS Mann-Salinas, EA AF Caldwell, Nicole W. Guymon, Charles H. Aden, James K. Akers, Kevin S. Mann-Salinas, Elizabeth A. TI Bacterial Contamination of Burn Unit Employee Identity Cards SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID HOSPITAL-ACQUIRED INFECTION AB The purpose of this study was to identify the presence or absence of pathogenic bacteria on burn intensive care unit employees' common access cards (CACs) and identity badges (IDs) and to identify possible variables that may increase risk for the presence of those bacteria. A prospective, cross-sectional study was conducted in our regional Burn Center in which bacterial swab specimens were collected from both the CAC and ID of 10 burn intensive care unit employees in each of five cohorts (nurses, respiratory therapists, physical therapists, physicians, and ancillary staff). Ten additional paired samples, collected from direct care staff in the outpatient burn clinic, served as control. Additional information described how the cards were worn and if/ how they had been cleaned in the previous week. Fifty-eight CACs and 60 IDs were swabbed from participants. The overall contamination rate was 75%, with no trends identified based on how cards were worn. Bacteria were recovered from 86% (50/ 58) of CACs and 65% (39/ 60) of IDs, with CACs being significantly more contaminated overall than IDs (P <.01). In terms of potentially pathogenic bacteria, the overall rate was 3%, with 100% of those isolates coming from the outpatient clinic staff cohort (P <.001). When cleaned in the last week (n = 16), the contamination rate dropped to 50% overall (P =.003), indicating that even periodic cleaning appears to have a positive effect on bacterial contamination rates. The simple practice of routine identity card decontamination may reduce potential threats to patient safety as a result of nosocomial bacterial transmission. C1 [Caldwell, Nicole W.; Guymon, Charles H.; Aden, James K.; Akers, Kevin S.; Mann-Salinas, Elizabeth A.] US Army, Inst Surg Res, San Antonio, TX USA. RP Caldwell, NW (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA. EM Nicole.w.caldwell.civ@mail.mil NR 11 TC 0 Z9 0 U1 3 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1559-047X EI 1559-0488 J9 J BURN CARE RES JI J. Burn Care Res. PD SEP-OCT PY 2016 VL 37 IS 5 BP E470 EP E475 DI 10.1097/BCR.0000000000000254 PG 6 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA EC5ZD UT WOS:000388214900007 PM 26056757 ER PT J AU Kearns, RD Conlon, KM Matherly, AF Chung, KK Bebarta, VS Hansen, JJ Cancio, LC Peck, M Palmieri, TL AF Kearns, Randy D. Conlon, Kathe M. Matherly, Annette F. Chung, Kevin K. Bebarta, Vikhyat S. Hansen, Jacob J. Cancio, Leopoldo C. Peck, Michael Palmieri, Tina L. TI Guidelines for Burn Care Under Austere Conditions: Introduction to Burn Disaster, Airway and Ventilator Management, and Fluid Resuscitation SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID ORAL REHYDRATION SOLUTION; ACUTE CYANIDE TOXICITY; SUS-SCROFA MODEL; SODIUM THIOSULFATE; JAPAN EARTHQUAKE; INJURED PATIENTS; OXYGEN SUPPLIES; SOUTHERN REGION; HYDROXOCOBALAMIN; EXPERIENCE C1 [Kearns, Randy D.] Univ Mt Olive, Mt Olive, NC USA. [Conlon, Kathe M.] St Barnabas Hosp, Livingston, NJ USA. [Matherly, Annette F.] Univ Utah, Intermt Burn Ctr, Salt Lake City, UT USA. [Chung, Kevin K.; Bebarta, Vikhyat S.; Hansen, Jacob J.; Cancio, Leopoldo C.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Peck, Michael] Maricopa Integrated Hlth Syst, Phoenix, AZ USA. [Palmieri, Tina L.] Univ Calif Davis, Davis, CA 95616 USA. [Palmieri, Tina L.] Shriners Hosp Children, Sacramento, CA USA. RP Palmieri, TL (reprint author), Univ Calif Davis, Davis, CA 95616 USA.; Palmieri, TL (reprint author), Shriners Hosp Children, Sacramento, CA USA. EM tlpalmieri@ucdavis.edu RI bebarta, vikhyat/K-3476-2015 NR 73 TC 1 Z9 1 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1559-047X EI 1559-0488 J9 J BURN CARE RES JI J. Burn Care Res. PD SEP-OCT PY 2016 VL 37 IS 5 BP E427 EP E439 DI 10.1097/BCR.0000000000000304 PG 13 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA EC5ZD UT WOS:000388214900004 PM 27224004 ER PT J AU Sine, CR Belenkiy, SM Buel, AR Waters, JA Lundy, JB Henderson, JL Stewart, IJ Aden, JK Liu, NT Batchinsky, A Cannon, JW Cancio, LC Chung, KK AF Sine, Christy R. Belenkiy, Slava M. Buel, Allison R. Waters, J. Alan Lundy, Jonathan B. Henderson, Jonathan L. Stewart, Ian J. Aden, James K. Liu, Nehemiah T. Batchinsky, Andriy Cannon, Jeremy W. Cancio, Leopoldo C. Chung, Kevin K. TI Acute Respiratory Distress Syndrome in Burn Patients: A Comparison of the Berlin and American-European Definitions SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID INHALATION INJURY; CONSENSUS DEFINITION; MILITARY CASUALTIES; THERMAL-INJURY; LUNG INJURY; OUTCOMES; ARDS; OXYGENATION AB The purpose of this study was to compare the Berlin definition to the American-European Consensus Conference (AECC) definition in determining the prevalence of acute respiratory distress syndrome (ARDS) and associated mortality in the critically ill burn population. Consecutive patients admitted to our institution with burn injury that required mechanical ventilation for more than 24 hours were included for analysis. Included patients (N = 891) were classified by both definitions. The median age, % TBSA burn, and injury severity score (interquartile ranges) were 35 (24-51), 25 (11-45), and 18 (9-26), respectively. Inhalation injury was present in 35.5%. The prevalence of ARDS was 34% using the Berlin definition and 30.5% using the AECC definition (combined acute lung injury and ARDS), with associated mortality rates of 40.9 and 42.9%, respectively. Under the Berlin definition, mortality rose with increased ARDS severity (14.6% no ARDS; 16.7% mild; 44% moderate; and 59.7% severe, P < 0.001). By contrast, under the AECC definition increased mortality was seen only for ARDS category (14.7% no ARDS; 15.1% acute lung injury; and 46.0% ARDS, P < 0.001). The mortality of the 22 subjects meeting the AECC, but not the Berlin definition was not different from patients without ARDS (P =.91). The Berlin definition better stratifies ARDS in terms of severity and correctly excludes those with minimal disease previously captured by the AECC. C1 [Sine, Christy R.; Buel, Allison R.; Henderson, Jonathan L.; Cannon, Jeremy W.] San Antonio Mil Med Ctr, San Antonio, TX USA. [Belenkiy, Slava M.; Waters, J. Alan; Lundy, Jonathan B.; Aden, James K.; Liu, Nehemiah T.; Batchinsky, Andriy; Cancio, Leopoldo C.; Chung, Kevin K.] US Army, Inst Surg Res, San Antonio, TX USA. [Lundy, Jonathan B.; Stewart, Ian J.; Cannon, Jeremy W.; Chung, Kevin K.] Uniformed Hlth Serv Univ Hlth Sci, Bethesda, MD USA. [Stewart, Ian J.] David Grant Med Ctr, Travis Air Force Base, CA USA. [Cancio, Leopoldo C.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. RP Chung, KK (reprint author), 3698 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA. EM kevin.k.chung.mil@mail.mil FU Clinical Trials Task Area and Comprehensive Intensive Care Research Task Area, US Army Institute of Surgical Research, Ft Sam Houston, Texas FX This study has been supported by the Clinical Trials Task Area and Comprehensive Intensive Care Research Task Area, US Army Institute of Surgical Research, Ft Sam Houston, Texas. NR 24 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1559-047X EI 1559-0488 J9 J BURN CARE RES JI J. Burn Care Res. PD SEP-OCT PY 2016 VL 37 IS 5 BP E461 EP E469 DI 10.1097/BCR.0000000000000348 PG 9 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA EC5ZD UT WOS:000388214900006 PM 27070223 ER PT J AU Beely, BM Campbell, JE Meyer, A Langer, T Negaard, K Chung, KK Cap, AP Cancio, LC Batchinsky, AI AF Beely, Brendan M. Campbell, James E. Meyer, Andrew Langer, Thomas Negaard, Kathryn Chung, Kevin K. Cap, Andrew P. Cancio, Leopoldo C. Batchinsky, Andriy I. TI Electron Microscopy as a Tool for Assessment of Anticoagulation Strategies During Extracorporeal Life Support: The Proof Is on the Membrane SO ASAIO JOURNAL LA English DT Article DE extracorporeal membrane oxygenation; extracorporeal life support; anticoagulation; heparin; acute respiratory distress syndrome ID RESPIRATORY-DISTRESS-SYNDROME; MULTIDETECTOR COMPUTED-TOMOGRAPHY; GAS-EXCHANGE; THROMBOTIC DEPOSITS; OXYGENATION; HEPARIN; MICROPARTICLES; PLATELET; ASSIST AB Extracorporeal life support (ECLS) is fast becoming more common place for use in adult patients failing mechanical ventilation. Management of coagulation and thrombosis has long been a major complication in the use of ECLS therapies. Scanning electron microscopy (SEM) of membrane oxygenators (MOs) after use in ECLS circuits can offer novel insight into any thrombotic material deposition on the MO. In this pilot study, we analyzed five explanted MOs immediately after use in a sheep model of different acute respiratory distress syndrome (ARDS). We describe our methods of MO dissection, sample preparation, image capture, and results. Of the five MOs analyzed, those that received continuous heparin infusion showed very little thrombosis formation or other clot material, whereas those that were used with only initial heparin bolus showed readily apparent thrombotic material. C1 [Beely, Brendan M.; Batchinsky, Andriy I.] Geneva Fdn, Tacoma, WA USA. [Beely, Brendan M.; Meyer, Andrew; Negaard, Kathryn; Chung, Kevin K.; Cap, Andrew P.; Cancio, Leopoldo C.; Batchinsky, Andriy I.] USAISR, Ft Sam Houston, TX USA. [Campbell, James E.] Triserv Res Lab, San Antonio, TX USA. [Meyer, Andrew] Univ Texas San Antonio, Hlth Sci Ctr, San Antonio, TX USA. [Langer, Thomas] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dipartimento Anestesia Rianimaz & Emergenza Urgen, Milan, Italy. RP Beely, BM (reprint author), US Army Inst Surg Res, Multiorgan Support & Preservat Task Area, Battlefield Hlth & Trauma Res Inst, 3650 Chambers Pass,Bldg 3610 BHT2, Ft Sam Houston, TX 78234 USA. EM bbeely@gmail.com NR 23 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1058-2916 EI 1538-943X J9 ASAIO J JI Asaio J. PD SEP-OCT PY 2016 VL 62 IS 5 BP 525 EP 532 DI 10.1097/MAT.0000000000000394 PG 8 WC Engineering, Biomedical; Transplantation SC Engineering; Transplantation GA EC1OH UT WOS:000387874900007 PM 27258220 ER PT J AU Gowring, LE Johnson, R Hivnor, CM Henning, JS AF Gowring, Lena Elizabeth Johnson, Ryan Hivnor, Chad Mitchell Henning, Jeffrey Scott TI Cutaneous Artifactual Disease Represented as Recurrent Toxic Epidermal Necrolysis SO CUTIS LA English DT Letter C1 [Gowring, Lena Elizabeth; Hivnor, Chad Mitchell; Henning, Jeffrey Scott] San Antonio Mil Med Ctr, Dept Dermatol, San Antonio, TX USA. [Johnson, Ryan] Kellar Army Community Hosp, West Point, NY USA. RP Gowring, LE (reprint author), Dept Dermatol, 2200 Bergquist Dr,Ste 1, Lackland AFB, TX 78236 USA. EM Lena.gowring@us.af.mil NR 5 TC 0 Z9 0 U1 0 U2 0 PU QUADRANT HEALTHCOM INC PI PARSIPPANY PA 7 CENTURY DRIVE, STE 302, PARSIPPANY, NJ 07054-4603 USA SN 0011-4162 EI 2326-6929 J9 CUTIS JI Cutis PD SEP PY 2016 VL 98 IS 3 BP E6 EP E7 PG 2 WC Dermatology SC Dermatology GA EC3IV UT WOS:000388020700003 PM 27814420 ER PT J AU Finkel, A Klaric, JS Yerry, J Choi, YS AF Finkel, A. Klaric, J. S. Yerry, J. Choi, Y. S. TI Headaches in Soldiers with Mild Traumatic Brain Injury/Concussion: Relationships to Occupational Outcomes SO HEADACHE LA English DT Meeting Abstract CT 58th Annual Scientific Meeting of the American-Headache-Society CY JUN 09-12, 2016 CL San Diego, CA SP Amer Headache Soc C1 [Finkel, A.] Carolina Headche Inst, Durham, NC USA. [Klaric, J. S.] Womack Army Med Ctr, Ft Bragg, NC USA. [Yerry, J.; Choi, Y. S.] Womack Army Med Ctr, Fayetteville, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0017-8748 EI 1526-4610 J9 HEADACHE JI Headache PD SEP PY 2016 VL 56 IS 8 MA PS81LB BP 1400 EP 1400 PG 1 WC Clinical Neurology SC Neurosciences & Neurology GA EC1IA UT WOS:000387856900040 ER PT J AU Muldoon, SF Pasqualetti, F Gu, S Cieslak, M Grafton, ST Vettel, JM Bassett, DS AF Muldoon, Sarah Feldt Pasqualetti, Fabio Gu, Shi Cieslak, Matthew Grafton, Scott T. Vettel, Jean M. Bassett, Danielle S. TI Stimulation-Based Control of Dynamic Brain Networks SO PLOS COMPUTATIONAL BIOLOGY LA English DT Article ID TRANSCRANIAL MAGNETIC STIMULATION; THETA BURST STIMULATION; FUNCTIONAL CONNECTIVITY; RESTING-STATE; TMS; SCHIZOPHRENIA; PLASTICITY; MEMORY; NEUROSTIMULATION; NEUROMODULATION AB The ability to modulate brain states using targeted stimulation is increasingly being employed to treat neurological disorders and to enhance human performance. Despite the growing interest in brain stimulation as a form of neuromodulation, much remains unknown about the network-level impact of these focal perturbations. To study the system wide impact of regional stimulation, we employ a data-driven computational model of nonlinear brain dynamics to systematically explore the effects of targeted stimulation. Validating predictions from network control theory, we uncover the relationship between regional controllability and the focal versus global impact of stimulation, and we relate these findings to differences in the underlying network architecture. Finally, by mapping brain regions to cognitive systems, we observe that the default mode system imparts large global change despite being highly constrained by structural connectivity. This work forms an important step towards the development of personalized stimulation protocols for medical treatment or performance enhancement. C1 [Muldoon, Sarah Feldt; Gu, Shi; Vettel, Jean M.; Bassett, Danielle S.] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA. [Muldoon, Sarah Feldt; Vettel, Jean M.] US Army Res Lab, Aberdeen Proving Ground, MD USA. [Muldoon, Sarah Feldt] SUNY Buffalo, Dept Math, Buffalo, NY USA. [Muldoon, Sarah Feldt] SUNY Buffalo, Computat & Data Enabled Sci & Engn Program, Buffalo, NY USA. [Pasqualetti, Fabio] Univ Calif Riverside, Dept Mech Engn, Riverside, CA 92521 USA. [Gu, Shi] Univ Penn, Appl Math & Computat Sci Grad Program, Philadelphia, PA 19104 USA. [Cieslak, Matthew; Grafton, Scott T.; Vettel, Jean M.] Univ Calif Santa Barbara, Dept Psychol & Brain Sci, Santa Barbara, CA 93106 USA. [Bassett, Danielle S.] Univ Penn, Dept Elect & Syst Engn, Philadelphia, PA 19104 USA. RP Bassett, DS (reprint author), Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA.; Bassett, DS (reprint author), Univ Penn, Dept Elect & Syst Engn, Philadelphia, PA 19104 USA. EM dsb@seas.upenn.edu OI Muldoon, Sarah/0000-0002-2830-9291; Pasqualetti, Fabio/0000-0002-8457-8656; Grafton, Scott/0000-0003-4015-3151 FU Army Research Laboratory; John D. and Catherine T. MacArthur Foundation; Alfred P. Sloan Foundation; Army Research Office [W911NF-14-1-0679]; National Institute of Mental Health [2-R01-DC-009209-11]; National Institute of Child Health and Human Development [1R01HD086888-01]; Office of Naval Research; National Science Foundation [BCS-1441502, BCS-1430087, BCS-1430279]; Institute for Collaborative Biotechnologies through US Army Research Office [W911NF-09-0001]; [W911NF-10-2-0022] FX Research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-10-2-0022. DSB acknowledges support from the John D. and Catherine T. MacArthur Foundation, the Alfred P. Sloan Foundation, the Army Research Office (W911NF-14-1-0679), the National Institute of Mental Health (2-R01-DC-009209-11), the National Institute of Child Health and Human Development (1R01HD086888-01), the Office of Naval Research, and the National Science Foundation (BCS-1441502 and BCS-1430087). FP acknowledges support from the National Science Foundation (BCS-1430279) and STG acknowledges support from the Institute for Collaborative Biotechnologies through the US Army Research Office (W911NF-09-0001). The content is solely the responsibility of the authors and does not necessarily represent the official views of any of the funding agencies. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 61 TC 2 Z9 2 U1 7 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-734X EI 1553-7358 J9 PLOS COMPUT BIOL JI PLoS Comput. Biol. PD SEP PY 2016 VL 12 IS 9 AR e1005076 DI 10.1371/journal.pcbi.1005076 PG 23 WC Biochemical Research Methods; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Mathematical & Computational Biology GA EB8RN UT WOS:000387658600014 PM 27611328 ER PT J AU Costanza, DP Blacksmith, N Coats, MR Severt, JB DeCostanza, AH AF Costanza, David P. Blacksmith, Nikki Coats, Meredith R. Severt, Jamie B. DeCostanza, Arwen H. TI The Effect of Adaptive Organizational Culture on Long-Term Survival SO JOURNAL OF BUSINESS AND PSYCHOLOGY LA English DT Article DE Organizational culture; Organizational performance; Survival analysis; Adaptability ID SUSTAINED COMPETITIVE ADVANTAGE; VOLUNTARY TURNOVER; CORPORATE CULTURE; FIRM PERFORMANCE; JOB-SATISFACTION; INNOVATION; MODEL; WORK; ADAPTABILITY; DETERMINANTS AB Purpose Organizational culture is a critical resource for organizations to adapt to dynamic environments and to survive in the long term. Unfortunately, a lack of clarity exists in the conceptualization of adaptive cultures and little empirical research investigates its impact on survival. Therefore, the purpose of the present study was twofold: (1) to identify, define, and develop a measure of adaptive organizational culture and (2) to demonstrate the effect of adaptive culture on organizational survival. Design/Methodology/Approach An adaptive culture rating scale was developed based on a review of the existing literature. Ninety-five organizations founded prior to 1940 were rated on nine characteristics of adaptive culture. Ratings were used to predict likelihood to survive using a Cox regression with proportional hazards survival analysis. Findings Exploratory factor analysis revealed two broad factors of adaptive culture, values toward change and action-orientation. Findings indicate organizations with adaptive cultures were more likely to survive. Implications The present effort provided evidence that culture can serve as an adaptive mechanism with effects spanning decades. Leaders should focus on establishing adaptive cultural norms and values in order to increase chances of surviving. Originality/Value This is one of the first historiometric studies to develop and utilize a measure of adaptive culture. Further, this study looked at the impact of adaptive culture on long-term organizational outcomes using survival analysis, a statistical technique not often employed in the organizational literature. C1 [Costanza, David P.; Blacksmith, Nikki; Coats, Meredith R.; Severt, Jamie B.] George Washington Univ, Dept Org Sci & Commun, 600 21st St, Washington, DC 20052 USA. [DeCostanza, Arwen H.] US Army Res Lab, 459 Mulberry Point Rd, Aberdeen, MD 21005 USA. RP Costanza, DP (reprint author), George Washington Univ, Dept Org Sci & Commun, 600 21st St, Washington, DC 20052 USA. EM dcostanz@gwu.edu; nikkiblacksmith@gmail.com NR 87 TC 0 Z9 0 U1 10 U2 10 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0889-3268 EI 1573-353X J9 J BUS PSYCHOL JI J. Bus. Psychol. PD SEP PY 2016 VL 31 IS 3 BP 361 EP 381 DI 10.1007/s10869-015-9420-y PG 21 WC Business; Psychology, Applied SC Business & Economics; Psychology GA EB4PK UT WOS:000387354300003 ER PT J AU Tumlin, T Griep, M AF Tumlin, Travis Griep, Mark TI Single and Multi-Layer Graphene Stack Protective Coatings Against Directed Ozone Degradation SO JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY LA English DT Article DE Graphene; Multi-Layer; UV Ozone; Degradation ID LAYER GRAPHENE; ULTRAVIOLET-IRRADIATION; TRANSPARENT ELECTRODES; SOLAR-CELLS; FUNCTIONALIZATION; REDUCTION; EXPOSURE; SHEETS; FILMS AB Solar cell technology is a key research area with efforts focused on producing highly efficient, cost-effective, and scalable energy harvesting devices. Graphene is a promising candidate for replacing silicon based solar cells owing to its high electron mobility, chemical inertness, and transparency. Although progress has been made in evaluating graphene's response to UV/Ozone exposure, the complete destruction of graphene and the correlation of number of layers to degradation resistance is still lacking. In the present work, we report the full degradation of single and few layer graphene under UV/Ozone exposure. The sheet resistance was reduced from 434.6 +/- 107.1 for single layer graphene to 56.2 +/- 1.1 for four layers. After 5 minutes of exposure, change in sheet resistance rapidly increased for monolayer graphene while the increase for bilayer and few-layer graphene was relatively small. It was determined that additional layers of stacked graphene beyond bilayer increases the survival time by a factor of 2. These results show that the stacking of graphene leads to better electrical performance along with larger survival rates. C1 [Tumlin, Travis; Griep, Mark] US Army, Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. RP Griep, M (reprint author), US Army, Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. FU Internship/Research Participation Program at the U.S. Army Research Laboratory, U.S. Environmental Protection Agency FX This project was supported in part by an appointment to the Internship/Research Participation Program at the U.S. Army Research Laboratory, U.S. Environmental Protection Agency, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and EPA. NR 39 TC 0 Z9 0 U1 6 U2 6 PU AMER SCIENTIFIC PUBLISHERS PI VALENCIA PA 26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USA SN 1533-4880 EI 1533-4899 J9 J NANOSCI NANOTECHNO JI J. Nanosci. Nanotechnol. PD SEP PY 2016 VL 16 IS 9 BP 9907 EP 9913 DI 10.1166/jnn.2016.13053 PG 7 WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA EB1CW UT WOS:000387085000128 ER PT J AU Arguelles, AP Kube, CM Hu, P Turner, JA AF Arguelles, Andrea P. Kube, Christopher M. Hu, Ping Turner, Joseph A. TI Mode-converted ultrasonic scattering in polycrystals with elongated grains SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID DUPLEX MICROSTRUCTURES; BACKSCATTERING AB Elastic wave scattering is used to study polycrystalline media for a wide range of applications. Received signals, which include scattering from the randomly oriented grains comprising the polycrystal, contain information from which useful microstructural parameters may often be inferred. Recently, a mode-converted diffuse ultrasonic scattering model was developed for evaluating the scattered response of a transverse wave from an incident longitudinal wave in a polycrystalline medium containing equiaxed single-phase grains with cubic elastic symmetry. In this article, that theoretical mode-converted scattering model is modified to account for grain elongation within the sample. The model shows the dependence on scattering angle relative to the grain axis orientation. Experimental measurements were performed on a sample of 7475-T7351 aluminum using a pitch-catch transducer configuration. The results show that the mode-converted scattering can be used to determine the dimensions of the elongated grains. The average grain shape determined from the experimental measurements is compared with dimensions extracted from electron backscatter diffraction, an electron imaging technique. The results suggest that mode-converted diffuse ultrasonic scattering has the potential to quantify detailed information about grain microstructure. (C) 2016 Acoustical Society of America. C1 [Arguelles, Andrea P.; Kube, Christopher M.; Hu, Ping; Turner, Joseph A.] Univ Nebraska, Dept Mech & Mat Engn, W342 Nebraska Hall, Lincoln, NE 68588 USA. [Kube, Christopher M.] US Army Res Lab, Vehicle Technol Directorate, Mech Div, Aberdeen, MD 21005 USA. [Hu, Ping] Wuhan Univ, Sch Power & Mech Engn, Wuhan 430072, Hubei, Peoples R China. RP Turner, JA (reprint author), Univ Nebraska, Dept Mech & Mat Engn, W342 Nebraska Hall, Lincoln, NE 68588 USA. EM jaturner@unl.edu RI Turner, Joseph/F-5165-2010 NR 32 TC 0 Z9 0 U1 5 U2 5 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 EI 1520-8524 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD SEP PY 2016 VL 140 IS 3 BP 1570 EP 1580 DI 10.1121/1.4962161 PG 11 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA EA9AO UT WOS:000386932500021 PM 27914376 ER PT J AU Zhang, SZ Kube, CM Song, YF Li, XB AF Zhang, Shuzeng Kube, Christopher M. Song, Yongfeng Li, Xiongbing TI A self-reciprocity calibration method for broadband focused transducers SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID FIELD; SENSITIVITY; BEAMS AB A procedure is developed for self-calibration of broadband, spherically focused ultrasonic transducers based on reciprocity. The input and received signals are measured in a pulse-echo configuration. These signals are used in conjunction with a multi-Gaussian beam model to obtain the electromechanical transfer function of the transducer. This calibration procedure is advantageous because it reduces the experimental configuration to a single transducer and a reflector. Experimental results indicate that the transfer function is insensitive to on-axis reflector placement. This result supports the feasibility of integrating the calibration procedure into actual testing in some situations. (C) 2016 Acoustical Society of America C1 [Zhang, Shuzeng; Song, Yongfeng; Li, Xiongbing] Cent S Univ, Sch Traff & Transportat Engn, Changsha 410075, Hunan, Peoples R China. [Kube, Christopher M.] US Army, Res Lab, Vehicle Technol Directorate, 4603 Flare Loop, Aberdeen Proving Ground, MD 21005 USA. RP Li, XB (reprint author), Cent S Univ, Sch Traff & Transportat Engn, Changsha 410075, Hunan, Peoples R China. EM zhangshuzeng123@163.com; christopher.m.kube.ctr@mail.mil; songyf_ut@163.com; lixb_ex@163.com FU National Natural Science Foundation of China [61271356, 51575541] FX This work was supported by the National Natural Science Foundation of China (Grant Nos. 61271356 and 51575541). NR 20 TC 0 Z9 0 U1 4 U2 4 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 EI 1520-8524 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD SEP PY 2016 VL 140 IS 3 BP EL236 EP EL241 DI 10.1121/1.4962376 PG 6 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA EA9AO UT WOS:000386932500003 PM 27914415 ER PT J AU Kutateladze, T Zangaladze, E Dolidze, N Mamatsashvili, T Tskhvaradze, L Andrews, ES Haddow, AD AF Kutateladze, Tamar Zangaladze, Ekaterine Dolidze, Nato Mamatsashvili, Tamar Tskhvaradze, Lamzira Andrews, Elizabeth S. Haddow, Andrew D. TI FIRST RECORD OF AEDES ALBOPICTUS IN GEORGIA AND UPDATED CHECKLIST OF REPORTED SPECIES SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Black Sea; chikungunya virus; dengue virus; West Nile virus; Zika virus ID TRANSCRIPTASE-PCR ASSAY; MOSQUITOS AB Mosquito surveillance was carried out in Batumi, Georgia, in August 2014. Aedes albopictus was detected for the first time, Which brought the number of reported mosquito species in Georgia to 32. An updated checklist of the mosquitoes of Georgia is provided. C1 [Kutateladze, Tamar; Zangaladze, Ekaterine; Dolidze, Nato; Mamatsashvili, Tamar; Tskhvaradze, Lamzira] Natl Ctr Dis Control & Publ Hlth, 9 Mikheil Asatiani St, Tbilisi 380077, Rep of Georgia. [Andrews, Elizabeth S.; Haddow, Andrew D.] US Army, Div Virol, Med Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. RP Kutateladze, T (reprint author), Natl Ctr Dis Control & Publ Hlth, 9 Mikheil Asatiani St, Tbilisi 380077, Rep of Georgia. FU Defense Threat Reduction Agency (DTRA) Cooperative Biological Engagement Program (CBEP) FX This study was funded by the Defense Threat Reduction Agency (DTRA) Cooperative Biological Engagement Program (CBEP). The authors wish to thank Rik Obiso, Theresa Gallagher, and Magda Metreveli for their assistance in the coordination of logistical activities. The views expressed in this article are those of the authors and do not represent the official policy or position of the US Department of the Army, Department of Defense, or the US Government. NR 27 TC 0 Z9 0 U1 1 U2 1 PU AMER MOSQUITO CONTROL ASSOC PI MOUNT LAUREL PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA SN 8756-971X EI 1943-6270 J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD SEP PY 2016 VL 32 IS 3 BP 230 EP 233 PG 4 WC Entomology SC Entomology GA EB6YC UT WOS:000387530500008 PM 27802403 ER PT J AU Loeppky, JA Sheard, AC Salgado, RM Mermier, CM AF Loeppky, J. A. Sheard, A. C. Salgado, R. M. Mermier, C. M. TI VESTPD as a measure of ventilatory acclimatization to hypobaric hypoxia SO PHYSIOLOGY INTERNATIONAL LA English DT Article DE acclimatization; acid-base balance; breathing frequency; Haldane effect; hypobaric hypoxia; hypocapnia; hyperventilation; tidal volume ID MUSCULAR EXERCISE; SIMULATED ALTITUDE; MOUNT EVEREST; LACTATE; MEN; HUMANS; WORK AB This study compared the ventilation response to an incremental ergometer exercise at two altitudes: 633 mmHg (resident altitude = 1,600 m) and following acute decompression to 455 mmHg (approximate to 4,350 m altitude) in eight male cyclists and runners. At 455 mmHg, the VESTPD at RER < 1.0 was significantly lower and the VEBTPS was higher because of higher breathing frequency; at VO(2)max, both VESTPD and VEBTPS were not significantly different. As percent of VO(2)max, the VEBTPS was nearly identical and VESTPD was 30% lower throughout the exercise at 455 mmHg. The lower VESTPD at lower pressure differs from two classical studies of acclimatized subjects (Silver Hut and OEII), where VESTPD at submaximal workloads was maintained or increased above that at sea level. The lower VESTPD at 455 mmHg in unacclimatized subjects at submaximal workloads results from acute respiratory alkalosis due to the initial fall in HbO(2) (approximate to 0.17 pHa units), reduction in PACO2 (approximate to 5 mmHg) and higher PAO(2) throughout the exercise, which are partially pre-established during acclimatization. Regression equations from these studies predict VESTPD from VO2 and P-B in unacclimatized and acclimatized subjects. The attainment of ventilatory acclimatization to altitude can be estimated from the measured vs. predicted difference in VESTPD at low workloads after arrival at altitude. C1 [Loeppky, J. A.] VA Med Ctr, Res Sect, Albuquerque, NM USA. [Loeppky, J. A.; Mermier, C. M.] Univ New Mexico, Dept Hlth Exercise & Sports Sci, Albuquerque, NM 87131 USA. [Sheard, A. C.] Calif State Univ Los Angeles, Sch Kinesiol & Nutr Sci, Los Angeles, CA 90032 USA. [Salgado, R. M.] US Army Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA USA. [Loeppky, J. A.] 2725,7th St South, Cranbrook, BC V1C 4R8, Canada. RP Loeppky, JA (reprint author), Univ New Mexico, Dept Hlth Exercise & Sports Sci, Albuquerque, NM 87131 USA.; Loeppky, JA (reprint author), 2725,7th St South, Cranbrook, BC V1C 4R8, Canada. EM Loeppkyj@telus.net FU Research Allocations Committee at the University of New Mexico; Overhead Funds Allocation Committee at the University of New Mexico; Graduate and Professional Student Association at the University of New Mexico FX This work was funded in part by the Research Allocations Committee, Overhead Funds Allocation Committee and Graduate and Professional Student Association at the University of New Mexico. NR 38 TC 1 Z9 1 U1 0 U2 0 PU AKADEMIAI KIADO RT PI BUDAPEST PA PRIELLE K U 19, PO BOX 245,, H-1117 BUDAPEST, HUNGARY SN 2498-602X J9 PHYSIOL INT JI Physiol. Int. PD SEP PY 2016 VL 103 IS 3 BP 377 EP 391 DI 10.1556/2060.103.2016.3.1 PG 15 WC Physiology SC Physiology GA EB5SV UT WOS:000387441600011 PM 28229643 ER PT J AU Howard, JT Sparks, PJ AF Howard, Jeffrey T. Sparks, P. Johnelle TI Does allostatic load calculation method matter? Evaluation of different methods and individual biomarkers functioning by race/ethnicity and educational level SO AMERICAN JOURNAL OF HUMAN BIOLOGY LA English DT Article ID NUTRITION EXAMINATION SURVEY; CUMULATIVE BIOLOGICAL RISK; RACIAL RESIDENTIAL SEGREGATION; ALL-CAUSE MORTALITY; NATIONAL-HEALTH; CARDIOVASCULAR-DISEASE; SOCIOECONOMIC-STATUS; STRESS MEDIATORS; UNITED-STATES; COMMON COLD AB ObjectivesUsing nationally representative data for adults of age 25 years and older from four waves of the National Health and Nutrition Examination Survey (NHANES), collected from 2003 through 2010, this study examines differences in individual health markers used to calculate allostatic load, with particular attention given to stratification by race/ethnicity and educational level. MethodsFactor analysis with maximum likelihood estimation was used. Fisher's r to z transformation test was used to determine whether or not observed differences in factor loadings were statistically significant. ResultsThe findings reveal the unidimensionality of the concept of allostatic load and the underlying differences in associations between individual biomarkers and summary measures of allostatic load. Additionally, metabolic processes tend to be the most important predictor of allostatic load for all adults; however, inflammatory measures are more important in determining allostatic load scores for non-Hispanic blacks compared to non-Hispanic whites and for adults with less than a college education compared to adults with some college or a college degree. ConclusionsThese findings highlight the continued importance of studying the concept of weathering or allostatic load at the population level and need to better understand how population groups facing exclusion from economic, social, and political power may internalize this position which may cause early health deterioration and ultimate mortality chance through different expression of health insults and premature aging. Am. J. Hum. Biol. 28:627-635, 2016. (c) 2016 Wiley Periodicals, Inc. C1 [Howard, Jeffrey T.] US Army Inst Surg Res, San Antonio, TX USA. [Howard, Jeffrey T.] US Army Inst Surg Res, Epidemiol & Biostat Dept, Jbsa San Antonio, TX USA. [Sparks, P. Johnelle] Univ Texas San Antonio, Dept Demog, 501 W Cesar E Chavez Blvd,Monterey Bldg, San Antonio, TX 78249 USA. RP Sparks, PJ (reprint author), Univ Texas San Antonio, Dept Demog, 501 W Cesar E Chavez Blvd,Monterey Bldg, San Antonio, TX 78249 USA. EM johnelle.sparks@utsa.edu FU University of Texas at San Antonio, Office of the Vice President for Research FX Contract grant sponsor: University of Texas at San Antonio, Office of the Vice President for Research. NR 83 TC 3 Z9 3 U1 3 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1042-0533 EI 1520-6300 J9 AM J HUM BIOL JI Am. J. Hum. Biol. PD SEP-OCT PY 2016 VL 28 IS 5 BP 627 EP 635 DI 10.1002/ajhb.22843 PG 9 WC Anthropology; Biology SC Anthropology; Life Sciences & Biomedicine - Other Topics GA DW5LB UT WOS:000383685200004 PM 26877153 ER PT J AU Singamaneni, SR Prater, JT Narayan, J AF Singamaneni, Srinivasa Rao Prater, John Thomas Narayan, Jagdish TI Multifunctional epitaxial systems on silicon substrates SO APPLIED PHYSICS REVIEWS LA English DT Review ID CHEMICAL-VAPOR-DEPOSITION; BATIO3 THIN-FILMS; X-RAY-DIFFRACTION; ROOM-TEMPERATURE FERROMAGNETISM; PULSED-LASER DEPOSITION; POSITIVE EXCHANGE BIAS; MISFIT DISLOCATIONS; ZINC-OXIDE; ZNO FILMS; SEMICONDUCTOR HETEROSTRUCTURES AB Multifunctional heterostructures can exhibit a wide range of functional properties, including colossal magneto-resistance, magnetocaloric, and multiferroic behavior, and can display interesting physical phenomena including spin and charge ordering and strong spin-orbit coupling. However, putting this functionality to work remains a challenge. To date, most of the work reported in the literature has dealt with heterostructures deposited onto closely lattice matched insulating substrates such as DyScO3, SrTiO3 (STO), or STO buffered Si(100) using concepts of lattice matching epitaxy (LME). However, strain in heterostructures grown by LME is typically not fully relaxed and the layers contain detrimental defects such as threading dislocations that can significantly degrade the physical properties of the films and adversely affect the device characteristics. In addition, most of the substrates are incompatible with existing CMOS-based technology, where Si (100) substrates dominate. This review discusses recent advances in the integration of multifunctional oxide and non-oxide materials onto silicon substrates. An alternative thin film growth approach, called " domain matching epitaxy," is presented which identifies approaches for minimizing lattice strain and unwanted defects in large misfit systems (7%-25% and higher). This approach broadly allows for the integration of multifunctional materials onto silicon substrates, such that sensing, computation, and response functions can be combined to produce next generation "smart" devices. In general, pulsed laser deposition has been used to epitaxially grow these materials, although the concepts developed here can be extended to other deposition techniques, as well. It will be shown that TiN and yttria-stabilized zirconia template layers provide promising platforms for the integration of new functionality into silicon-based computer chips. This review paper reports on a number of thin-film heterostructure systems that span a variety of ferroelectric, multiferroic, magnetic, photocatalytic, and smart materials. Their properties have been extensively investigated and their functionality found to be comparable to films grown on single-crystal oxide substrates previously reported by researchers in this field. In addition, this review explores the utility of using laser processing to introduce stable defects in a controlled way and induce magnetism and engineer the optical and electrical properties of nonmagnetic oxides such as BaTiO3, VO2, NiO, and TiO2 as an alternative for incorporating additional magnetic and conducting layers into the structure. These significant materials advancements herald a flurry of exciting new advances in CMOS-compatible multifunctional devices. Published by AIP Publishing. C1 [Singamaneni, Srinivasa Rao; Prater, John Thomas; Narayan, Jagdish] North Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Singamaneni, Srinivasa Rao; Prater, John Thomas] US Army, Div Mat Sci, Res Off, Res Triangle Pk, NC 27709 USA. [Singamaneni, Srinivasa Rao] Univ Texas El Paso, Dept Phys, El Paso, TX 79968 USA. RP Singamaneni, SR (reprint author), North Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA.; Singamaneni, SR (reprint author), US Army, Div Mat Sci, Res Off, Res Triangle Pk, NC 27709 USA.; Singamaneni, SR (reprint author), Univ Texas El Paso, Dept Phys, El Paso, TX 79968 USA. EM ssingam@ncsu.edu FU National Academy of Science (NAS), USA for NRC; Army Research Office [W911NF-04-D-0003]; State of North Carolina; National Science Foundation FX S.R.S. acknowledges National Academy of Science (NAS), USA for awarding the NRC postdoctoral research associate fellowship. The authors are pleased to acknowledge the support of the Army Research Office under Grant No. W911NF-04-D-0003. Also, the authors acknowledge the use of the Analytical Instrumentation Facility (AIF) at North Carolina State University, which is supported by the State of North Carolina and the National Science Foundation. NR 221 TC 0 Z9 0 U1 64 U2 65 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 1931-9401 J9 APPL PHYS REV JI Appl. Phys. Rev. PD SEP PY 2016 VL 3 IS 3 AR 031301 DI 10.1063/1.4955413 PG 38 WC Physics, Applied SC Physics GA EA8RM UT WOS:000386906200007 ER PT J AU Warrender, JM AF Warrender, Jeffrey M. TI Laser hyperdoping silicon for enhanced infrared optoelectronic properties SO APPLIED PHYSICS REVIEWS LA English DT Review ID ION-IMPLANTED SILICON; DOPED CRYSTALLINE SILICON; RAPID SOLIDIFICATION; IMPURITY BAND; MICROSTRUCTURED SILICON; ALLOY SOLIDIFICATION; MACROSCOPIC THEORY; PLANAR INTERFACE; ANNEALED SILICON; OPTICAL-EMISSION AB Pulsed laser melting and rapid solidification have attracted interest for decades as a method to achieve impurity concentrations in silicon orders of magnitude above the equilibrium solubility limit. The incorporation of sulfur into silicon using this technique led to the observation of strong broadband infrared absorption in the resulting material. This observation, combined with interest in impurity band optoelectronic device concepts, has resulted in renewed interest in laser techniques for achieving high impurity concentrations. In this paper, I review the literature that led to the present understanding of laser hyperdoping and provide a summary of the optical and optoelectronic measurements made on sulfur hyperdoped silicon to date. I mention recent work exploring transition metal impurities and discuss how considerations discovered in early solidification and later rapid solidification work inform our approaches to kinetically trapping such impurities. I also provide a simplified picture of how a laser hyperdoping process is typically carried out, as an entry point for an experimentalist seeking to fabricate such layers. C1 [Warrender, Jeffrey M.] US Army, ARDEC, Benet Labs, Watervliet, NY 12189 USA. RP Warrender, JM (reprint author), US Army, ARDEC, Benet Labs, Watervliet, NY 12189 USA. EM jwarrend@post.harvard.edu OI Warrender, Jeffrey/0000-0001-6932-8344 NR 110 TC 4 Z9 4 U1 9 U2 9 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 1931-9401 J9 APPL PHYS REV JI Appl. Phys. Rev. PD SEP PY 2016 VL 3 IS 3 AR 031104 DI 10.1063/1.4960752 PG 12 WC Physics, Applied SC Physics GA EA8RM UT WOS:000386906200004 ER PT J AU Lee, DJ Schnitzlein, CW Wolf, JP Vythilingam, M Rasmusson, AM Hoge, CW AF Lee, Daniel J. Schnitzlein, Carla W. Wolf, Jonathan P. Vythilingam, Meena Rasmusson, Ann M. Hoge, Charles W. TI PSYCHOTHERAPY VERSUS PHARMACOTHERAPY FOR POSTTRAUMATIC STRESS DISORDER: SYSTEMIC REVIEW AND META-ANALYSES TO DETERMINE FIRST-LINE TREATMENTS SO DEPRESSION AND ANXIETY LA English DT Article DE PTSD; posttraumatic stress disorder; pharmacotherapy; psychotherapy; VA; DoD; ISTSS; NICE; WHO; Australian; Department of Defense; International Society for the Study of Traumatic Stress; National Institute for Clinical Excellence; World Health Organization ID RANDOMIZED CONTROLLED-TRIAL; PLACEBO-CONTROLLED TRIAL; EYE-MOVEMENT DESENSITIZATION; COGNITIVE-BEHAVIORAL THERAPY; VENLAFAXINE EXTENDED-RELEASE; DOUBLE-BLIND; CLINICAL-TRIAL; CHRONIC PTSD; PAROXETINE TREATMENT; MILITARY VETERANS AB BackgroundCurrent clinical practice guidelines (CPGs) for posttraumatic stress disorder (PTSD) offer contradictory recommendations regarding use of medications or psychotherapy as first-line treatment. Direct head-to-head comparisons are lacking. MethodsSystemic review of Medline, EMBASE, PILOTS, Cochrane Central Register of Controlled Trials, PsycINFO, and Global Health Library was conducted without language restrictions. Randomized clinical trials 8 weeks in duration using structured clinical interview-based outcome measures, active-control conditions (e.g. supportive psychotherapy), and intent-to-treat analysis were selected for analyses. Independent review, data abstraction, and bias assessment were performed using standardized processes. Study outcomes were grouped around conventional follow-up time periods (3, 6, and 9 months). Combined effect sizes were computed using meta-analyses for medication versus control, medication pre-/posttreatment, psychotherapy versus control, and psychotherapy pre-/posttreatment. ResultsEffect sizes for trauma-focused psychotherapies (TFPs) versus active control conditions were greater than medications versus placebo and other psychotherapies versus active controls. TFPs resulted in greater sustained benefit over time than medications. Sertraline, venlafaxine, and nefazodone outperformed other medications, although potential for methodological biases were high. Improvement following paroxetine and fluoxetine treatment was small. Venlafaxine and stress inoculation training (SIT) demonstrated large initial effects that decreased over time. Bupropion, citalopram, divalproex, mirtazapine, tiagabine, and topiramate failed to differentiate from placebo. Aripiprazole, divalproex, guanfacine, and olanzapine failed to differentiate from placebo when combined with an antidepressant. ConclusionsStudy findings support use of TFPs over nontrauma-focused psychotherapy or medication as first-line interventions. Second-line interventions include SIT, and potentially sertraline or venlafaxine, rather than entire classes of medication, such as SSRIs. Future revisions of CPGs should prioritize studies that utilize active controls over waitlist or treatment-as-usual conditions. Direct head-to-head trials of TFPs versus sertraline or venlafaxine are needed. C1 [Lee, Daniel J.] Off Evidence Based Practice, San Antonio, TX 78234 USA. [Lee, Daniel J.; Schnitzlein, Carla W.] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD 20814 USA. [Schnitzlein, Carla W.] Bayne Jones Army Community Hosp, Dept Behav Hlth, Ft Polk, LA USA. [Wolf, Jonathan P.] Walter Reed Natl Mil Med Ctr, Natl Intrepid Ctr Excellence, Bethesda, MD USA. [Vythilingam, Meena] Headquarters US Marine Corps, Hlth Serv, Arlington, VA USA. [Rasmusson, Ann M.] Boston Univ, Sch Med, VA Boston Healthcare Syst, Womens Hlth Sci Div,Natl Ctr PTSD, Boston, MA 02118 USA. [Rasmusson, Ann M.] Boston Univ, Sch Med, Dept Vet Affairs, Boston, MA 02118 USA. [Rasmusson, Ann M.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA. [Hoge, Charles W.] Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD USA. RP Lee, DJ (reprint author), Off Evidence Based Practice, San Antonio, TX 78234 USA. EM Daniel.J.Lee82.mil@mail.mil FU Resilience Therapeutics, Inc. FX Ann Rasmusson is a paid consultant for Resilience Therapeutics, Inc. All other authors have nothing to disclose. NR 78 TC 2 Z9 2 U1 10 U2 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1091-4269 EI 1520-6394 J9 DEPRESS ANXIETY JI Depress. Anxiety PD SEP PY 2016 VL 33 IS 9 BP 792 EP 806 DI 10.1002/da.22511 PG 15 WC Psychology, Clinical; Psychiatry; Psychology SC Psychology; Psychiatry GA DW5SR UT WOS:000383707700003 PM 27126398 ER PT J AU Ananworanich, J Chomont, N Eller, LA Kroon, E Tovanabutra, S Bose, M Nau, M Fletcher, JLK Tipsuk, S Vandergeeten, C O'Connell, RJ Pinyakorn, S Michael, N Phanuphak, N Robb, ML AF Ananworanich, Jintanat Chomont, Nicolas Eller, Leigh Ann Kroon, Eugene Tovanabutra, Sodsai Bose, Meera Nau, Martin Fletcher, James L. K. Tipsuk, Somporn Vandergeeten, Claire O'Connell, Robert J. Pinyakorn, Suteeraporn Michael, Nelson Phanuphak, Nittaya Robb, Merlin L. CA RV217 & RV254 SEARCH010 Study Grp TI HIV DNA Set Point is Rapidly Established in Acute HIV Infection and Dramatically Reduced by Early ART SO EBIOMEDICINE LA English DT Article DE Acute HIV infection; Art; HIV DNA; Reservoir; Persistence ID CD4 CELL COUNT; ANTIRETROVIRAL THERAPY; DISEASE PROGRESSION; LATENT RESERVOIR; SIZE; REMISSION; IMPACT; LEVEL; DECAY; CURE AB HIV DNA is a marker of HIV persistence that predicts HIV progression and remission, but its kinetics in early acute HIV infection (AHI) is poorly understood. We longitudinally measured the frequency of peripheral blood mononuclear cells harboring total and integrated HIV DNA in 19 untreated and 71 treated AHI participants, for whom 50 were in the earliest Fiebig I/II (HIV IgM -) stage, that is <= 2 weeks from infection. Without antiretroviral therapy (ART), HIV DNA peaked at 2 weeks after enrollment, reaching a set-point 2 weeks later with little change thereafter. There was a marked divergence of HIV DNA values between the untreated and treated groups that occurred within the first 2weeks of ART and increased with time. ART reduced total HIV DNA levels by 20-fold after 2 weeks and 316-fold after 3 years. Therefore, very early ART offers the opportunity to significantly reduce the frequency of cells harboring HIV DNA. (C) 2016 The Authors. Published by Elsevier B.V. C1 [Ananworanich, Jintanat; Eller, Leigh Ann; Tovanabutra, Sodsai; Bose, Meera; Nau, Martin; Pinyakorn, Suteeraporn; Michael, Nelson; Robb, Merlin L.] US Mil HIV Res Program, Walter Reed Army Inst Res, Silver Spring, MD USA. [Ananworanich, Jintanat; Eller, Leigh Ann; Tovanabutra, Sodsai; Bose, Meera; Nau, Martin; Pinyakorn, Suteeraporn; Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Ananworanich, Jintanat; Kroon, Eugene; Fletcher, James L. K.; Tipsuk, Somporn; Phanuphak, Nittaya] Armed Forces Res Inst Med Sci, Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, Thailand. [Ananworanich, Jintanat; Kroon, Eugene; Fletcher, James L. K.; Tipsuk, Somporn; Phanuphak, Nittaya] Univ Montreal, CRCHUM, Montreal, PQ, Canada. [Chomont, Nicolas; O'Connell, Robert J.] Univ Montreal, Dept Microbiol Infectiol & Immunol, Montreal, PQ, Canada. [Chomont, Nicolas; Vandergeeten, Claire] Vaccine & Gene Therapy Inst Florida, Port St Lucie, FL USA. Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Ananworanich, J (reprint author), US Mil HIV Res Program, 6720A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA. EM jananworanich@hivresearch.org NR 29 TC 4 Z9 4 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 2352-3964 J9 EBIOMEDICINE JI EBioMedicine PD SEP PY 2016 VL 11 BP 68 EP 72 DI 10.1016/j.ebiom.2016.07.024 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA EA8II UT WOS:000386878100019 PM 27460436 ER PT J AU Taylor, AM Phillips, K Patel, KV Turk, DC Dworkin, RH Beaton, D Clauw, DJ Gignac, MAM Markman, JD Williams, DA Bujanover, S Burke, LB Carr, DB Choy, EH Conaghan, PG Cowan, P Farrar, JT Freeman, R Gewandter, J Gilron, I Goli, V Gover, TD Haddox, JD Kerns, RD Kopecky, EA Lee, DA Malamut, R Mease, P Rappaport, BA Simon, LS Singh, JA Smith, SM Strand, V Tugwell, P Vanhove, GF Veasley, C Walco, GA Wasan, AD Witter, J AF Taylor, Ann M. Phillips, Kristine Patel, Kushang V. Turk, Dennis C. Dworkin, Robert H. Beaton, Dorcas Clauw, Daniel J. Gignac, Monique A. M. Markman, John D. Williams, David A. Bujanover, Shay Burke, Laurie B. Carr, Daniel B. Choy, Ernest H. Conaghan, Philip G. Cowan, Penney Farrar, John T. Freeman, Roy Gewandter, Jennifer Gilron, Ian Goli, Veeraindar Gover, Tony D. Haddox, J. David Kerns, Robert D. Kopecky, Ernest A. Lee, David A. Malamut, Richard Mease, Philip Rappaport, Bob A. Simon, Lee S. Singh, Jasvinder A. Smith, Shannon M. Strand, Vibeke Tugwell, Peter Vanhove, Gertrude F. Veasley, Christin Walco, Gary A. Wasan, Ajay D. Witter, James TI Assessment of physical function and participation in chronic pain clinical trials: IMMPACT/OMERACT recommendations SO PAIN LA English DT Review DE OMERACT; IMMPACT; Pain; Physical performance measures; Patient-reported outcomes; Physical functioning; Physical activity; Accelerometer; Work; Employment; HRQOL; Social participation; Caregiver burden; Clinical trials ID PATIENT-REPORTED OUTCOMES; LOW-BACK-PAIN; EARLY RHEUMATOID-ARTHRITIS; QUALITY-OF-LIFE; COMMUNITY INTEGRATION QUESTIONNAIRE; HEALTH-ASSESSMENT QUESTIONNAIRE; WORK LIMITATIONS QUESTIONNAIRE; SICKNESS IMPACT PROFILE; TASK-FORCE REPORT; PSYCHOMETRIC PROPERTIES AB Although pain reduction is commonly the primary outcome in chronic pain clinical trials, physical functioning is also important. A challenge in designing chronic pain trials to determine efficacy and effectiveness of therapies is obtaining appropriate information about the impact of an intervention on physical function. The Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) and Outcome Measures in Rheumatology (OMERACT) convened a meeting to consider assessment of physical functioning and participation in research on chronic pain. The primary purpose of this article is to synthesize evidence on the scope of physical functioning to inform work on refining physical function outcome measurement. We address issues in assessing this broad construct and provide examples of frequently used measures of relevant concepts. Investigators can assess physical functioning using patient-reported outcome (PRO), performance-based, and objective measures of activity. This article aims to provide support for the use of these measures, covering broad aspects of functioning, including work participation, social participation, and caregiver burden, which researchers should consider when designing chronic pain clinical trials. Investigators should consider the inclusion of both PROs and performance-based measures as they provide different but also important complementary information. The development and use of reliable and valid PROs and performance-based measures of physical functioning may expedite development of treatments, and standardization of these measures has the potential to facilitate comparison across studies. We provide recommendations regarding important domains to stimulate research to develop tools that are more robust, address consistency and standardization, and engage patients early in tool development. C1 [Taylor, Ann M.] Cardiff Univ, Sch Med, Ctr Med Educ, Cardiff, S Glam, Wales. [Phillips, Kristine] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA. [Patel, Kushang V.; Turk, Dennis C.; Walco, Gary A.] Univ Washington, Dept Anesthesiol & Pain Med, Box 356540, Seattle, WA 98195 USA. [Dworkin, Robert H.; Gewandter, Jennifer; Smith, Shannon M.] Univ Rochester, Sch Med & Dent, Dept Anesthesiol, Rochester, NY USA. [Beaton, Dorcas] Univ Toronto, Dept Occupat Sci & Occupat Therapy, Toronto, ON M5S 1A1, Canada. [Beaton, Dorcas; Gignac, Monique A. M.] Univ Toronto, Inst Work & Hlth, Toronto, ON M5S 1A1, Canada. [Clauw, Daniel J.; Williams, David A.] Univ Michigan, Dept Anesthesiol, Ann Arbor, MI 48109 USA. [Markman, John D.] Univ Rochester, Dept Neurol, Rochester, NY USA. [Bujanover, Shay] Depomed, Newark, CA USA. [Burke, Laurie B.] LORAGroup LLC, Royal Oak, MD USA. [Burke, Laurie B.] Univ Maryland, Dept Hlth Serv Res, Baltimore, MD 21201 USA. [Carr, Daniel B.] Tufts Univ, Sch Med, Publ Hlth & Community Med, Boston, MA 02111 USA. [Choy, Ernest H.] Cardiff Univ, Div Infect & Immun, Cardiff, S Glam, Wales. [Conaghan, Philip G.] Univ Leeds, NIHR Leeds Musculoskeletal Biomed Res Unit, Leeds, W Yorkshire, England. [Conaghan, Philip G.] Univ Leeds, Inst Rheumat & Musculoskeletal Med, Leeds, W Yorkshire, England. [Cowan, Penney] Amer Chron Pain Assoc, Rocklin, CA USA. [Farrar, John T.] Univ Penn, Dept Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA. [Freeman, Roy] Harvard Univ, Dept Neurol, Cambridge, MA 02138 USA. [Gilron, Ian] Queens Univ, Dept Anesthesiol, Ottawa, ON, Canada. [Goli, Veeraindar] Duke Univ, Med Ctr, Dept Psychiat, Durham, NC 27710 USA. [Goli, Veeraindar] Pfizer Inc, Durham, NC USA. [Gover, Tony D.] US Army Med Res & Mat Command, Clin & Rehabil Med Res Program, Ft Detrick, MD USA. [Haddox, J. David] Purdue Pharma LP, Stamford, CT USA. [Kerns, Robert D.] Vet Affairs Connecticut Healthcare Syst, Dept Vet Affairs, West Haven, CT USA. [Kerns, Robert D.] Yale Univ, Dept Psychiat & Psychol, New Haven, CT USA. [Kopecky, Ernest A.] Collegium Pharmaceut Inc, Canton, MA USA. [Lee, David A.] Chadds Ford, Pennsylvania, PA USA. [Malamut, Richard] Teva Pharmaceut, N Wales, PA USA. [Mease, Philip] Swedish Med Ctr, Rheumatol Clin Res Div, Seattle, WA USA. [Mease, Philip] Univ Washington, Sch Med, Seattle, WA USA. [Mease, Philip] Stanford Univ, Div Immunol Rheumatol, Palo Alto, CA 94304 USA. [Rappaport, Bob A.] Analges Concepts LLC, Arlington, VA USA. [Simon, Lee S.] SDG Consulting LLC, Cambridge, MA USA. [Singh, Jasvinder A.] Birmingham Vet Affairs Med Ctr, Med Serv, Birmingham, AL USA. [Singh, Jasvinder A.] Mayo Clin, Coll Med, Dept Orthoped Surg, Rochester, MN USA. [Strand, Vibeke] Stanford Univ, Sch Med, Div Immunol Rheumatol, Palo Alto, CA 94304 USA. [Tugwell, Peter] Univ Ottawa, Fac Med, Ctr Global Hlth, Ottawa, ON, Canada. [Vanhove, Gertrude F.] Jazz Pharmaceut, Palo Alto, CA USA. [Veasley, Christin] Chron Pain Res Alliance, Washington, DC USA. [Wasan, Ajay D.] Univ Pittsburgh, Sch Med, Dept Anesthesiol, Pittsburgh, PA USA. [Witter, James] NIH, Bldg 10, Bethesda, MD 20892 USA. RP Turk, DC (reprint author), Univ Washington, Dept Anesthesiol & Pain Med, Box 356540, Seattle, WA 98195 USA. EM turkdc@uw.edu OI Tugwell, Peter/0000-0001-5062-0556 FU Analgesic; Anesthetic; Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION); FDA FX The views expressed in this article are those of the authors. The reader should infer no official endorsement by the US Department of Veterans Affairs, US FDA, or the US National Institutes of Health. Support for the meeting was provided by the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership with the FDA, which has received grants, contracts, and other revenue for its activities from the FDA, multiple pharmaceutical and device companies, and other sources. NR 210 TC 0 Z9 0 U1 12 U2 12 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0304-3959 EI 1872-6623 J9 PAIN JI Pain PD SEP PY 2016 VL 157 IS 9 BP 1836 EP 1850 DI 10.1097/j.pain.0000000000000577 PG 15 WC Anesthesiology; Clinical Neurology; Neurosciences SC Anesthesiology; Neurosciences & Neurology GA DZ7AH UT WOS:000386014700002 PM 27058676 ER PT J AU Fries, CA Villamaria, CY Spencer, JR Rickard, RF Gorantla, VS Davis, MR AF Fries, C. Anton Villamaria, Carole Y. Spencer, Jerry R. Rickard, Rory F. Gorantla, Vijay S. Davis, Michael R. TI A Porcine Orthotopic Forelimb Vascularized Composite Allotransplantation Model: Technical Considerations and Translational Implications SO PLASTIC AND RECONSTRUCTIVE SURGERY LA English DT Article; Proceedings Paper CT Military Health System Research Symposium CY AUG 17-21, 2014 CL Fort Lauderdale, FL ID OPERATION ENDURING FREEDOM; OUTBRED PIG-POPULATIONS; TISSUE ALLOTRANSPLANTATION; MOLECULAR CHARACTERIZATION; TRANSPLANTATION RESEARCH; INTERNATIONAL REGISTRY; UPPER EXTREMITY; IRAQI FREEDOM; SWINE; HAND AB Background: The restoration of complex tissue deficits with vascularized composite allotransplantation is a paradigm shift in reconstructive surgery. Clinical adoption of vascularized composite allotransplantation is limited by the need for systemic immunosuppression, with associated morbidity and mortality. Small-animal models lack the biological fidelity and preclinical relevance to enable translation of immunologic insights to humans. Large-animal models have been described; however, limitations persist, including the inability of heterotopic models to evaluate functional nerve regeneration, and the sensitivity of primates to toxicity of immunosuppressive drugs. The authors' novel orthotopic porcine limb transplant model has broad applicability and translational relevance to both immunologic and functional outcomes after vascularized composite allotransplantation. Methods: Recipients underwent amputation at a level corresponding to the mid forearm. Replantation or transplantation of grafts was performed by plate fixation of the radio-ulna, microsurgical repair of brachial artery and median nerve, and extensor and flexor tendon repairs. Viability of replants was monitored clinically and radiologically. Transplants were monitored for clinicopathologic signs of rejection. Animals mobilized freely postoperatively. Results: Replantations remained viable until the endpoint of 14 days. Transplants developed Banff grade 4 acute rejection by postoperative day 7. Doppler sonography and angiography confirmed vascular patency. Serial biopsy specimens of skin and histopathology of replants at endpoint confirmed tissue viability and bone healing. Conclusions: An orthotopic load-bearing porcine forelimb vascularized composite allotransplantation model was successfully established. Technical, procedural, and logistic considerations were optimized to allow model use for immunologic, bone healing, functional nerve regeneration, and other translational studies. C1 US Army, Inst Surg Res, San Antonio, TX USA. Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. 59MDW Sci & Technol, Joint Base San Antonio, San Antonio, TX USA. Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA. RP Fries, CA (reprint author), 76 Praedium, Bristol BS6 6WB, Avon, England. EM antonfries@gmail.com NR 39 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0032-1052 EI 1529-4242 J9 PLAST RECONSTR SURG JI Plast. Reconstr. Surg. PD SEP PY 2016 VL 138 IS 3 BP 461E EP 471E DI 10.1097/PRS.0000000000002451 PG 11 WC Surgery SC Surgery GA DZ7BH UT WOS:000386017900009 PM 27556621 ER PT J AU Kube, CM AF Kube, Christopher M. TI Elastic anisotropy of crystals SO AIP ADVANCES LA English DT Article ID TENSORS; CLOSEST; MEDIA AB An anisotropy index seeks to quantify how directionally dependent the properties of a system are. In this article, the focus is on quantifying the elastic anisotropy of crystalline materials. Previous elastic anisotropy indices are reviewed and their shortcomings discussed. A new scalar log-Euclidean anisotropy measure AL is proposed, which overcomes these deficiencies. It is based on a distance measure in a log-Euclidean space applied to fourth-rank elastic tensors. AL is an absolute measure of anisotropy where the limiting case of perfect isotropy yields zero. It is a universal measure of anisotropy applicable to all crystalline materials. Specific examples of strong anisotropy are highlighted. A supplementary material provides an anisotropy table giving the values of AL for 2,176 crystallite compounds. (C) 2016 Author(s). C1 [Kube, Christopher M.] US Army Res Lab, Vehicle Technol Directorate, Bldg 4603, Aberdeen Proving Ground, MD 21005 USA. RP Kube, CM (reprint author), US Army Res Lab, Vehicle Technol Directorate, Bldg 4603, Aberdeen Proving Ground, MD 21005 USA. EM christopher.m.kube.ctr@mail.mil NR 27 TC 2 Z9 2 U1 2 U2 2 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 2158-3226 J9 AIP ADV JI AIP Adv. PD SEP PY 2016 VL 6 IS 9 AR 095209 DI 10.1063/1.4962996 PG 6 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Science & Technology - Other Topics; Materials Science; Physics GA DZ2LW UT WOS:000385674300062 ER PT J AU Jung, T Gordon, ND Bauer, P Bromwich, DH Chevallier, M Day, JJ Dawson, J Doblas-Reyes, F Fairall, C Goessling, HF Holland, M Inoue, J Iversen, T Klebe, S Lemke, P Losch, M Makshtas, A Mills, B Nurmi, P Perovich, D Reid, P Renfrew, IA Smith, G Svensson, G Tolstykh, M Yang, QH AF Jung, Thomas Gordon, Neil D. Bauer, Peter Bromwich, David H. Chevallier, Matthieu Day, Jonathan J. Dawson, Jackie Doblas-Reyes, Francisco Fairall, Christopher Goessling, Helge F. Holland, Marika Inoue, Jun Iversen, Trond Klebe, Stefanie Lemke, Peter Losch, Martin Makshtas, Alexander Mills, Brian Nurmi, Pertti Perovich, Donald Reid, Philip Renfrew, Ian A. Smith, Gregory Svensson, Gunilla Tolstykh, Mikhail Yang, Qinghua TI ADVANCING POLAR PREDICTION CAPABILITIES ON DAILY TO SEASONAL TIME SCALES SO BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY LA English DT Article ID SEA-ICE THICKNESS; CLIMATE MODELS; FORECASTING SYSTEM; ENSEMBLE; WEATHER; PREDICTABILITY; IMPACT; SKILL; OCEAN; PERTURBATIONS AB The polar regions have been attracting more and more attention in recent years, fueled by the perceptible impacts of anthropogenic climate change. Polar climate change provides new opportunities, such as shorter shipping routes between Europe and East Asia, but also new risks such as the potential for industrial accidents or emergencies in ice-covered seas. Here, it is argued that environmental prediction systems for the polar regions are less developed than elsewhere. There are many reasons for this situation, including the polar regions being (historically) lower priority, with fewer in situ observations, and with numerous local physical processes that are less well represented by models. By contrasting the relative importance of different physical processes in polar and lower latitudes, the need for a dedicated polar prediction effort is illustrated. Research priorities are identified that will help to advance environmental polar prediction capabilities. Examples include an improvement of the polar observing system; the use of coupled atmosphere-sea ice-ocean models, even for short-term prediction; and insight into polar-lower latitude linkages and their role for forecasting. Given the enormity of some of the challenges ahead, in a harsh and remote environment such as the polar regions, it is argued that rapid progress will only be possible with a coordinated international effort. More specifically, it is proposed to hold a Year of Polar Prediction (YOPP) from mid-2017 to mid-2019 in which the international research and operational forecasting communites will work together with stakeholders in a period of intensive observing: modeling, prediction, verification, user engagement, and educational activities. C1 [Jung, Thomas; Goessling, Helge F.; Klebe, Stefanie; Lemke, Peter; Losch, Martin] AWI, Bremerhaven, Germany. [Jung, Thomas] Univ Bremen, Bremen, Germany. [Gordon, Neil D.] Neil Gordon Consulting, Otaki, New Zealand. [Bauer, Peter] ECMWF, Reading, Berks, England. [Bromwich, David H.] Ohio State Univ, Columbus, OH 43210 USA. [Chevallier, Matthieu] CNRM, Toulouse, France. [Day, Jonathan J.] Univ Reading, Reading, Berks, England. [Dawson, Jackie] Univ Ottawa, Dept Geog, Ottawa, ON, Canada. [Doblas-Reyes, Francisco] IC3, ICREA, Barcelona, Spain. [Doblas-Reyes, Francisco] BSC, Barcelona, Spain. [Fairall, Christopher] NOAA, Boulder, CO USA. [Holland, Marika] NCAR, Boulder, CO USA. [Inoue, Jun] NIPR, Tachikawa, Tokyo, Japan. [Iversen, Trond] NMI, Oslo, Norway. [Makshtas, Alexander] AARI, St Petersburg, Russia. [Mills, Brian] Environm Canada, Waterloo, ON, Canada. [Nurmi, Pertti] FMI, Helsinki, Finland. [Perovich, Donald] CRREL, ERDC, Hanover, NH USA. [Reid, Philip] Bur Meteorol, Hobart, Tas, Australia. [Renfrew, Ian A.] Univ East Anglia, Norwich, Norfolk, England. [Smith, Gregory] Environm Canada, Montreal, PQ, Canada. [Svensson, Gunilla] Univ Stockholm, Stockholm, Sweden. [Tolstykh, Mikhail] INM RAS, Moscow, Russia. [Tolstykh, Mikhail] Hydrometctr Russia, Moscow, Russia. [Yang, Qinghua] NMEFC, Beijing, Peoples R China. RP Jung, T (reprint author), Alfred Wegener Inst, Helmholtz Ctr Polar & Marine Res, Bussestr 24, D-27570 Bremerhaven, Germany. EM thomas.jung@awi.de RI Jung, Thomas/J-5239-2012; OI Jung, Thomas/0000-0002-2651-1293; Chevallier, Matthieu/0000-0003-2033-166X FU AWI FX Mohamed Dahoui from ECMWF is acknowledged for providing Fig. 3. Soumia Serrar contributed to producing Figs. 4 and 5. Gunnar Spreen and Dimitris Menemenlis provided the original configuration for the 4-km simulations with the MITgcm that formed the basis for Fig. 6. Contributions to the PPP Trust Fund are acknowledged as well as AWI's financial contribution to hosting the ICO. NR 83 TC 5 Z9 5 U1 7 U2 7 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0003-0007 EI 1520-0477 J9 B AM METEOROL SOC JI Bull. Amer. Meteorol. Soc. PD SEP PY 2016 VL 97 IS 9 BP 1631 EP + DI 10.1175/BAMS-D-14-00246.1 PG 19 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA DZ5PG UT WOS:000385913400014 ER PT J AU Hart, JD Bansal, K Murphy, TE Roy, R AF Hart, Joseph D. Bansal, Kanika Murphy, Thomas E. Roy, Rajarshi TI Experimental observation of chimera and cluster states in a minimal globally coupled network SO CHAOS LA English DT Article ID OSCILLATORS; SYNCHRONIZATION; PARADIGM AB A "chimera state" is a dynamical pattern that occurs in a network of coupled identical oscillators when the symmetry of the oscillator population is broken into synchronous and asynchronous parts. We report the experimental observation of chimera and cluster states in a network of four globally coupled chaotic opto-electronic oscillators. This is the minimal network that can support chimera states, and our study provides new insight into the fundamental mechanisms underlying their formation. We use a unified approach to determine the stability of all the observed partially synchronous patterns, highlighting the close relationship between chimera and cluster states as belonging to the broader phenomenon of partial synchronization. Our approach is general in terms of network size and connectivity. We also find that chimera states often appear in regions of multistability between global, cluster, and desynchronized states. Published by AIP Publishing. C1 [Hart, Joseph D.; Murphy, Thomas E.; Roy, Rajarshi] Univ Maryland, Inst Res Elect & Appl Phys, College Pk, MD 20742 USA. [Hart, Joseph D.; Roy, Rajarshi] Univ Maryland, Dept Phys, College Pk, MD 20742 USA. [Bansal, Kanika] SUNY Buffalo, Dept Math, Buffalo, NY 14260 USA. [Bansal, Kanika] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Murphy, Thomas E.] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. [Roy, Rajarshi] Univ Maryland, Inst Phys Sci & Technol, College Pk, MD 20742 USA. RP Hart, JD (reprint author), Univ Maryland, Inst Res Elect & Appl Phys, College Pk, MD 20742 USA.; Hart, JD (reprint author), Univ Maryland, Dept Phys, College Pk, MD 20742 USA. OI Hart, Joseph/0000-0002-9396-0574; Murphy, Thomas/0000-0002-8286-3832 FU ONR [N000141410443] FX We thank F. Sorrentino, L. M. Pecora, and the authors of Ref. 22 9F. Bohm, A. Zakharova, E. Scholl, and K. Ludge) for helpful discussions. We gratefully acknowledge ONR for supporting this work through Grant No. N000141410443. NR 35 TC 4 Z9 4 U1 6 U2 6 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 1054-1500 EI 1089-7682 J9 CHAOS JI Chaos PD SEP PY 2016 VL 26 IS 9 AR 094801 DI 10.1063/1.4953662 PG 8 WC Mathematics, Applied; Physics, Mathematical SC Mathematics; Physics GA DZ0VH UT WOS:000385557300022 PM 27781456 ER PT J AU Lu, Z Wang, WY Wang, C AF Lu, Zhuo Wang, Wenye Wang, Cliff TI On the Evolution and Impact of Mobile Botnets in Wireless Networks SO IEEE TRANSACTIONS ON MOBILE COMPUTING LA English DT Article DE Mobile botnet; malware; proximity propagation; wireless networks; denial-of-service; modeling and evaluation AB A botnet in mobile networks is a collection of compromised nodes due to mobile malware, which are able to perform coordinated attacks. Different from Internet botnets, mobile botnets do not need to propagate using centralized infrastructures, but can keep compromising vulnerable nodes in close proximity and evolving organically via data forwarding. Such a distributed mechanism relies heavily on node mobility as well as wireless links, therefore it breaks down the underlying premise in existing epidemic modeling for Internet botnets. In this paper, we adopt a stochastic approach to study the evolution and impact of mobile botnets. We find that node mobility can be a trigger to botnet propagation storms: the average size (i.e., number of compromised nodes) of a botnet increases quadratically over time if the mobility range that each node can reach exceeds a threshold; otherwise, the botnet can only contaminate a limited number of nodes with average size always bounded above. This also reveals that mobile botnets can propagate at the fastest rate of quadratic growth in size, which is substantially slower than the exponential growth of Internet botnets. To measure the denial-of-service impact of a mobile botnet, we define a new metric, called last chipper time, which is the last time that service requests, even partially, can still be processed on time as the botnet keeps propagating and launching attacks. The last chipper time is identified to decrease at most on the order of 1 root B, where B is the network bandwidth. This result reveals that although increasing network bandwidth can help mobile services, it can, at the same time, indeed escalate the risk of services being disrupted by mobile botnets. C1 [Lu, Zhuo] Univ Memphis, Dept Comp Sci, Memphis, TN 38152 USA. [Wang, Wenye] North Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. [Wang, Cliff] Army Res Off, Res Triangle Pk, NC 27709 USA. RP Lu, Z (reprint author), Univ Memphis, Dept Comp Sci, Memphis, TN 38152 USA. EM zhuo.lu@memphis.edu; wwang@ncsu.edu; cliff.wang@us.army.mil FU US National Science Foundation (NSF) [CNS-142315, CNS-1018447] FX An earlier version of the work was published in IEEE INFO-COM 2014. The research in this paper was supported by US National Science Foundation (NSF) CNS-142315 and CNS-1018447. NR 29 TC 0 Z9 0 U1 3 U2 3 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1536-1233 EI 1558-0660 J9 IEEE T MOBILE COMPUT JI IEEE. Trans. Mob. Comput. PD SEP 1 PY 2016 VL 15 IS 9 BP 2304 EP 2316 DI 10.1109/TMC.2015.2492545 PG 13 WC Computer Science, Information Systems; Telecommunications SC Computer Science; Telecommunications GA DZ3AK UT WOS:000385715200013 ER PT J AU Regules, JA Cicatelli, SB Bennett, JW Paolino, KM Twomey, PS Moon, JE Kathcart, AK Hauns, KD Komisar, JL Qabar, AN Davidson, SA Dutta, S Griffith, ME Magee, CD Wojnarski, M Livezey, JR Kress, AT Waterman, PE Jongert, E Wille-Reece, U Volkmuth, W Emerling, D Robinson, WH Lievens, M Morelle, D Lee, CK Yassin-Rajkumar, B Weltzin, R Cohen, J Paris, RM Waters, NC Birkett, AJ Kaslow, DC Ballou, WR Ockenhouse, CF Vekemans, J AF Regules, Jason A. Cicatelli, Susan B. Bennett, Jason W. Paolino, Kristopher M. Twomey, Patrick S. Moon, James E. Kathcart, April K. Hauns, Kevin D. Komisar, Jack L. Qabar, Aziz N. Davidson, Silas A. Dutta, Sheetij Griffith, Matthew E. Magee, Charles D. Wojnarski, Mariusz Livezey, Jeffrey R. Kress, Adrian T. Waterman, Paige E. Jongert, Erik Wille-Reece, Ulrike Volkmuth, Wayne Emerling, Daniel Robinson, William H. Lievens, Marc Morelle, Danielle Lee, Cynthia K. Yassin-Rajkumar, Bebi Weltzin, Richard Cohen, Joe Paris, Robert M. Waters, Norman C. Birkett, Ashley J. Kaslow, David C. Ballou, W. Ripley Ockenhouse, Christian F. Vekemans, Johan TI Fractional Third and Fourth Dose of RTS,S/AS01 Malaria Candidate Vaccine: A Phase 2a Controlled Human Malaria Parasite Infection and Immunogenicity Study SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE RTS; S; AS01; delayed fractional dose; vaccine spacing; Plasmodium falciparum; malaria; immunogenicity; safety; efficacy; controlled human malaria parasite infection ID CIRCUMSPOROZOITE-PROTEIN; PLASMODIUM-FALCIPARUM; IMMUNIZATION; TRIAL; CHILDHOOD; SCHEDULES; EFFICACY; SAFETY; ASSAY AB Background. Three full doses of RTS,S/AS01 malaria vaccine provides partial protection against controlled human malaria parasite infection (CHMI) and natural exposure. Immunization regimens, including a delayed fractional third dose, were assessed for potential increased protection against malaria and immunologic responses. Methods.aEuro integral In a phase 2a, controlled, open-label, study of healthy malaria-naive adults, 16 subjects vaccinated with a 0-, 1-, and 2-month full-dose regimen (012M) and 30 subjects who received a 0-, 1-, and 7-month regimen, including a fractional third dose (Fx017M), underwent CHMI 3 weeks after the last dose. Plasmablast heavy and light chain immunoglobulin messenger RNA sequencing and antibody avidity were evaluated. Protection against repeat CHMI was evaluated after 8 months. Results.aEuro integral A total of 26 of 30 subjects in the Fx017M group (vaccine efficacy [VE], 86.7% [95% confidence interval [CI], 66.8%-94.6%]; P < .0001) and 10 of 16 in the 012M group (VE, 62.5% [95% CI, 29.4%-80.1%]; P = .0009) were protected against infection, and protection differed between schedules (P = .040, by the log rank test). The fractional dose boosting increased antibody somatic hypermutation and avidity and sustained high protection upon rechallenge. Discussions.aEuro integral A delayed third fractional vaccine dose improved immunogenicity and protection against infection. Optimization of the RTS,S/AS01 immunization regimen may lead to improved approaches against malaria. Clinical Trials Registration.aEuro integral NCT01857869. C1 [Regules, Jason A.; Bennett, Jason W.; Moon, James E.; Kathcart, April K.; Hauns, Kevin D.; Komisar, Jack L.; Qabar, Aziz N.; Dutta, Sheetij; Waters, Norman C.] Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD USA. [Twomey, Patrick S.; Wojnarski, Mariusz; Livezey, Jeffrey R.; Kress, Adrian T.] Walter Reed Army Inst Res, Expt Therapeut Branch, Silver Spring, MD USA. [Regules, Jason A.; Bennett, Jason W.; Twomey, Patrick S.; Moon, James E.; Kathcart, April K.; Hauns, Kevin D.; Komisar, Jack L.; Qabar, Aziz N.; Dutta, Sheetij; Wojnarski, Mariusz; Livezey, Jeffrey R.; Kress, Adrian T.; Paris, Robert M.; Waters, Norman C.] Walter Reed Army Inst Res, Mil Malaria Res Program, Silver Spring, MD USA. [Cicatelli, Susan B.; Paolino, Kristopher M.; Waterman, Paige E.] Walter Reed Army Inst Res, Translat Med Branch, Clin Trials Ctr, Silver Spring, MD USA. [Davidson, Silas A.] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD USA. [Regules, Jason A.; Bennett, Jason W.; Griffith, Matthew E.; Magee, Charles D.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Wille-Reece, Ulrike; Lee, Cynthia K.; Yassin-Rajkumar, Bebi; Weltzin, Richard; Ockenhouse, Christian F.] PATH Malaria Vaccine Initiat, Seattle, WA USA. [Volkmuth, Wayne; Emerling, Daniel; Robinson, William H.] Atreca, Redwood City, CA USA. [Jongert, Erik; Lievens, Marc; Morelle, Danielle; Cohen, Joe; Birkett, Ashley J.; Kaslow, David C.; Ballou, W. Ripley; Vekemans, Johan] GSK Vaccines, Rixensart, Belgium. RP Regules, JA (reprint author), USAMRIID, Dept Med, 1425 Porter St, Frederick, MD 21702 USA. EM jason.a.regules.mil@mail.mil FU GSK Biologicals; Department of Defense MMRP; PATH Malaria Vaccine Initiative; Bill and Melinda Gates Foundation FX This work was supported by GSK Biologicals, the Department of Defense MMRP, the PATH Malaria Vaccine Initiative (to GSK Vaccines and the MMRP), and the Bill and Melinda Gates Foundation (to the Malaria Vaccine Initiative and Atreca). NR 27 TC 3 Z9 3 U1 4 U2 4 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD SEP 1 PY 2016 VL 214 IS 5 BP 762 EP 771 DI 10.1093/infdis/jiw237 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA DY7YY UT WOS:000385346400015 PM 27296848 ER PT J AU Pajcin, M Banks, S White, JM Paech, GM Grant, C Tooley, K Johnson, K Kamimori, GH Della Vedova, CB AF Pajcin, M. Banks, S. White, J. M. Paech, G. M. Grant, C. Tooley, K. Johnson, K. Kamimori, G. H. Della Vedova, C. B. TI Decreased levels of salivary alpha-amylase are associated with greater driving performance deficits following one night of sleep deprivation SO JOURNAL OF SLEEP RESEARCH LA English DT Meeting Abstract CT 23rd Congress of the European-Sleep-Research-Society CY SEP 13-16, 2016 CL Bologna, ITALY SP European Sleep Res Soc C1 [Pajcin, M.; White, J. M.; Della Vedova, C. B.] Univ Sought Australia, Sch Pharm & Med Sci, Samson Inst, Adelaide, SA, Australia. [Banks, S.; Paech, G. M.; Grant, C.] Univ South Australia, Ctr Sleep Res, Adelaide, SA, Australia. [Tooley, K.; Johnson, K.] Def Sci & Technol Grp, Dept Def, Edinburg, SA, Australia. [Kamimori, G. H.] Walter Reed Army Inst Res, Behav Biol Branch, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0962-1105 EI 1365-2869 J9 J SLEEP RES JI J. Sleep Res. PD SEP PY 2016 VL 25 SU 1 SI SI MA P196 BP 153 EP 153 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA DW2AL UT WOS:000383445200385 ER PT J AU Doty, TJ So, CJ Quartana, PJ Ratcliffe, RH Bergman, EM Trach, SK Maguire, KM Cooper, DC Ephrem, D Yarnell, AM Capaldi, VF Moon, JE Balkin, TJ AF Doty, T. J. So, C. J. Quartana, P. J. Ratcliffe, R. H. Bergman, E. M. Trach, S. K. Maguire, K. M. Cooper, D. C. Ephrem, D. Yarnell, A. M. Capaldi, V. F. Moon, J. E. Balkin, T. J. TI Lack of recovery following sleep restriction: the role of caffeine SO JOURNAL OF SLEEP RESEARCH LA English DT Meeting Abstract CT 23rd Congress of the European-Sleep-Research-Society CY SEP 13-16, 2016 CL Bologna, ITALY SP European Sleep Res Soc C1 [Doty, T. J.; So, C. J.; Ratcliffe, R. H.; Bergman, E. M.; Trach, S. K.; Maguire, K. M.; Cooper, D. C.; Ephrem, D.; Yarnell, A. M.; Capaldi, V. F.; Moon, J. E.; Balkin, T. J.] Walter Reed Army Inst Res, Behav Biol, Silver Spring, MD USA. [Quartana, P. J.] Walter Reed Army Inst Res, Mil Psychiat, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0962-1105 EI 1365-2869 J9 J SLEEP RES JI J. Sleep Res. PD SEP PY 2016 VL 25 SU 1 SI SI MA P476 BP 241 EP 241 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA DW2AL UT WOS:000383445201097 ER PT J AU Margolis, LM Rivas, DA Ezzyat, Y Gaffney-Stomberg, E Young, AJ McClung, JP Fielding, RA Pasiakos, SM AF Margolis, Lee M. Rivas, Donato A. Ezzyat, Yassine Gaffney-Stomberg, Erin Young, Andrew J. McClung, James P. Fielding, Roger A. Pasiakos, Stefan M. TI Calorie Restricted High Protein Diets Downregulate Lipogenesis and Lower Intrahepatic Triglyceride Concentrations in Male Rats SO NUTRIENTS LA English DT Article DE low carbohydrate diet; fatty acid synthase; insulin resistance; fatty liver ID HEPATIC INSULIN-RESISTANCE; FATTY LIVER-DISEASE; DE-NOVO LIPOGENESIS; GLYCEMIC CONTROL; WEIGHT-LOSS; AMINO-ACID; BODY-COMPOSITION; ADIPOSE-TISSUE; ENERGY-INTAKE; CARBOHYDRATE AB The purpose of this investigation was to assess the influence of calorie restriction (CR) alone, higher-protein/lower-carbohydrate intake alone, and combined CR higher-protein/lower-carbohydrate intake on glucose homeostasis, hepatic de novo lipogenesis (DNL), and intrahepatic triglycerides. Twelve-week old male Sprague Dawley rats consumed ad libitum (AL) or CR (40% restriction), adequate (10%), or high (32%) protein (PRO) milk-based diets for 16 weeks. Metabolic profiles were assessed in serum, and intrahepatic triglyceride concentrations and molecular markers of de novo lipogenesis were determined in liver. Independent of calorie intake, 32% PRO tended to result in lower homeostatic model assessment of insulin resistance (HOMA-IR) values compared to 10% PRO, while insulin and homeostatic model assessment of -cell function (HOMA-) values were lower in CR than AL, regardless of protein intake. Intrahepatic triglyceride concentrations were 27.4 +/- 4.5 and 11.7 +/- 4.5 mu molg(-1) lower (p < 0.05) in CR and 32% PRO compared to AL and 10% PRO, respectively. Gene expression of fatty acid synthase (FASN), stearoyl-CoA destaurase-1 (SCD1) and pyruvate dehydrogenase kinase, isozyme 4 (PDK4) were 45% +/- 1%, 23% +/- 1%, and 57% +/- 1% lower (p < 0.05), respectively, in CR than AL, regardless of protein intake. Total protein of FASN and SCD were 50% +/- 1% and 26% +/- 1% lower (p < 0.05) in 32% PRO compared to 10% PRO, independent of calorie intake. Results from this investigation provide evidence that the metabolic health benefits associated with CRspecifically reduction in intrahepatic triglyceride contentmay be enhanced by consuming a higher-protein/lower-carbohydrate diet. C1 [Margolis, Lee M.; Rivas, Donato A.; Ezzyat, Yassine; Fielding, Roger A.] Tufts Univ, Nutr Exercise Physiol & Sarcopenia Lab, USDA, Jean Mayer Human Nutr Res Ctr Aging, Boston, MA 02111 USA. [Margolis, Lee M.; Young, Andrew J.; McClung, James P.; Pasiakos, Stefan M.] US Army, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. [Gaffney-Stomberg, Erin] US Army, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA. RP Pasiakos, SM (reprint author), US Army, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. EM Lee.Margolis@Tufts.edu; Donato.Rivas@Tufts.edu; Yassine.Ezzyat@Tufts.edu; Erin.G.Stomberg.civ@mail.mil; Andrew.J.Young.ctr@mail.mil; James.P.McClung8.civ@mail.mil; Roger.Fielding@Tufts.edu; Stefan.M.Pasiakos.civ@mail.mil RI Pasiakos, Stefan/E-6295-2014; OI Pasiakos, Stefan/0000-0002-5378-5820; Rivas, Donato/0000-0002-4500-6233; , Lee/0000-0002-0652-1304 FU US Army Medical Research and Material Command; Dairy Research Institute; USDA [58-1950-4-003]; T32 NIDDK training grant [5T32DK062032-23]; NIA [KAG047247A-A1] FX Any opinions, findings, conclusions, or recommendations expressed in this publication are the private views of the authors and are not to be construed as official or as reflecting the views of the Army or Department of Defense or U.S. Department of Agriculture (USDA). Any citations of commercial organizations and trade names in this report do not constitute an official Department of the Army or U.S. Department of Agriculture (USDA) endorsement of approval of the products or services of these organizations. This material is based on the work supported by the US Army Medical Research and Material Command, the Dairy Research Institute, and the USDA under agreement No. 58-1950-4-003. L.M.M. was supported by the T32 NIDDK training grant # 5T32DK062032-23 and D.A.R was supported by the NIA K01 award # KAG047247A-A1. NR 40 TC 0 Z9 0 U1 1 U2 1 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 2072-6643 J9 NUTRIENTS JI Nutrients PD SEP PY 2016 VL 8 IS 9 AR 571 DI 10.3390/nu8090571 PG 11 WC Nutrition & Dietetics SC Nutrition & Dietetics GA DZ0MM UT WOS:000385534000052 ER PT J AU Allen, CR Birge, HE Bartelt-Hunt, S Bevans, RA Burnett, JL Cosens, BA Cai, XM Garmestani, AS Linkov, I Scott, EA Solomon, MD Uden, DR AF Allen, Craig R. Birge, Hannah E. Bartelt-Hunt, Shannon Bevans, Rebecca A. Burnett, Jessica L. Cosens, Barbara A. Cai, Ximing Garmestani, Ahjond S. Linkov, Igor Scott, Elizabeth A. Solomon, Mark D. Uden, Daniel R. TI Avoiding Decline: Fostering Resilience and Sustainability in Midsize Cities SO SUSTAINABILITY LA English DT Article DE social-ecological systems; adaptive governance; transformative governance; cross-scale interactions; complexity; ecosystem services; resilience assessment; shrinking cities; urbanization; urban systems ID SOCIAL-ECOLOGICAL SYSTEMS; ECOSYSTEM SERVICES; GOVERNANCE; OPPORTUNITIES; CHALLENGES; MANAGEMENT AB Eighty-five percent of United States citizens live in urban areas. However, research surrounding the resilience and sustainability of complex urban systems focuses largely on coastal megacities (>1 million people). Midsize cities differ from their larger counterparts due to tight urban-rural feedbacks with their immediate natural environments that result from heavy reliance and close management of local ecosystem services. They also may be less path-dependent than larger cities due to shorter average connection length among system components, contributing to higher responsiveness among social, infrastructural, and ecological feedbacks. These distinct midsize city features call for a framework that organizes information and concepts concerning the sustainability of midsize cities specifically. We argue that an integrative approach is necessary to capture properties emergent from the complex interactions of the social, infrastructural, and ecological subsystems that comprise a city system. We suggest approaches to estimate the relative resilience of midsize cities, and include an example assessment to illustrate one such estimation approach. Resilience assessments of a midsize city can be used to examine why some cities end up on sustainable paths while others diverge to unsustainable paths, and which feedbacks may be partially responsible. They also provide insight into how city planners and decision makers can use information about the resilience of midsize cities undergoing growth or shrinkage relative to their larger and smaller counterparts, to transform them into long-term, sustainable social-ecological systems. C1 [Allen, Craig R.] Univ Nebraska, US Geol Survey, Nebraska Cooperat Fish & Wildlife Res Unit, Sch Nat Resources, Lincoln, NE 68583 USA. [Birge, Hannah E.; Bevans, Rebecca A.; Burnett, Jessica L.; Uden, Daniel R.] Univ Nebraska, Sch Nat Resources, Nebraska Cooperat Fish & Wildlife Res Unit, Lincoln, NE 68583 USA. [Bartelt-Hunt, Shannon] Univ Nebraska, Dept Civil Engn, Lincoln, NE 68583 USA. [Cosens, Barbara A.] Univ Idaho, Coll Law, Moscow, ID 83844 USA. [Cai, Ximing] Univ Illinois, Dept Civil & Environm Engn, Urbana, IL 61801 USA. [Garmestani, Ahjond S.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Linkov, Igor] US Army Corps Engineer, Engn Res & Dev Ctr, Concord, MA 01742 USA. [Scott, Elizabeth A.] Univ Idaho, Urban Design Ctr, Boise, ID 83702 USA. [Solomon, Mark D.] Univ Idaho, Idaho Water Resources Res Inst, Moscow, ID 83844 USA. RP Allen, CR (reprint author), Univ Nebraska, US Geol Survey, Nebraska Cooperat Fish & Wildlife Res Unit, Sch Nat Resources, Lincoln, NE 68583 USA. EM allencr@unl.edu; Hannah.birge@huskers.unl.edu; sbartelt2@unl.edu; bevansbecca@gmail.com; jburnett@huskers.unl.edu; bcosens@uidaho.edu; xmcai@illinois.edu; garmestani.ahjond@epa.gov; Igor.Linkov@usace.army.mil; bscott@uidaho.edu; msolomon@uidaho.edu; daniel.uden@huskers.unl.edu FU United States Geological Survey; Nebraska Game and Parks Commission; University of Nebraska-Lincoln; United States Fish and Wildlife Service; Wildlife Management Institute FX The Nebraska Cooperative Fish and Wildlife Research Unit is jointly supported by a cooperative agreement between the United States Geological Survey, the Nebraska Game and Parks Commission, the University of Nebraska-Lincoln, the United States Fish and Wildlife Service, and the Wildlife Management Institute. NR 53 TC 1 Z9 1 U1 27 U2 27 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 2071-1050 J9 SUSTAINABILITY-BASEL JI Sustainability PD SEP PY 2016 VL 8 IS 9 AR 844 DI 10.3390/su8090844 PG 24 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Environmental Sciences; Environmental Studies SC Science & Technology - Other Topics; Environmental Sciences & Ecology GA DZ0LC UT WOS:000385529400016 ER PT J AU Holtzclaw, A Mrsic, Z Managbanag, J Calvano, T Colombo, C AF Holtzclaw, Arthur Mrsic, Zorana Managbanag, Jim Calvano, Tatjana Colombo, Christopher TI Transfusion-transmitted malaria not preventable by current blood donor screening guidelines: a case report SO TRANSFUSION LA English DT Article ID UNITED-STATES AB BACKGROUND: Transfusion-transmitted malaria (TTM) is a well-known, though rare, entity in the United States with only 100 cases previously reported. With no Food and Drug Administration-approved screening tests of donated blood for malaria in the United States, prevention relies solely on deferral of the highest-risk donors. We present a case of TTM not preventable by these guidelines. CASE REPORT: A 76-year-old male presented with fever, hypotension, tachycardia, and a urinalysis consistent with a urinary tract infection. He was admitted to the intensive care unit and initiated on broad-spectrum antibiotics. On Hospital Day 2, he was incidentally found to have intraerythrocytic parasites on a peripheral smear, identified as Plasmodium malariae by polymerase chain reaction and was treated successfully with atovaquone-proguanil. The patient had no recent foreign travel or exposure to malaria but had received 15 units of blood products in the past 6 years. Index samples from the 10 most recent units were obtained, with one testing positive for P. malariae via serology. The donor was a 20-year-old male who immigrated to the United States from Liberia at the age of 5 with no subsequent travel or exposure to malaria. DISCUSSION: A review of current literature demonstrated that 71% of TTM cases occur from imperfect application of the current deferral guidelines. In this case, however, 15 years had elapsed between the donor's immigration and the transmission of the disease, placing him well outside any current deferral period. As such, the case demonstrates the need for continued development of highly sensitive and cost-effective laboratory screening for high-risk donors. C1 [Holtzclaw, Arthur; Mrsic, Zorana; Calvano, Tatjana; Colombo, Christopher] Dwight D Eisenhower Army Med Ctr, Dept Internal Med, Ft Gordon, GA USA. [Managbanag, Jim] Dwight D Eisenhower Army Med Ctr, Dept Pathol & Area Lab Serv, Ft Gordon, GA USA. RP Holtzclaw, A (reprint author), Dept Internal Med, 300 East Hosp Rd, Ft Gordon, GA 30905 USA. EM arthur.w.holtzclaw.mil@mail.mil NR 16 TC 0 Z9 0 U1 2 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD SEP PY 2016 VL 56 IS 9 BP 2221 EP 2224 DI 10.1111/trf.13680 PG 4 WC Hematology SC Hematology GA DZ4OL UT WOS:000385837900010 PM 27297115 ER PT J AU Cota, JM FakhriRavari, A Rowan, MP Chung, KK Murray, CK Akers, KS AF Cota, Jason M. FakhriRavari, Alireza Rowan, Matthew P. Chung, Kevin K. Murray, Clinton K. Akers, Kevin S. TI Intravenous Antibiotic and Antifungal Agent Pharmacokinetic-Pharmacodynamic Dosing in Adults with Severe Burn Injury SO CLINICAL THERAPEUTICS LA English DT Review DE antibiotics; antifungal agents; burns; pharmacokinetics; pharmacodynamics ID CRITICALLY-ILL PATIENTS; CONTINUOUS VENOVENOUS HEMOFILTRATION; STAPHYLOCOCCUS-AUREUS BACTEREMIA; MINIMUM INHIBITORY CONCENTRATION; RESPIRATORY-TRACT INFECTIONS; LIPOSOMAL AMPHOTERICIN-B; MAJOR THERMAL-INJURIES; HIGH-DOSE DAPTOMYCIN; POPULATION PHARMACOKINETICS; CLINICAL PHARMACODYNAMICS AB Purpose: Despite advances in the care of patients with severe burn injury, infection-related morbidity and mortality remain high and can potentially be reduced with antimicrobial dosing optimized for the infecting pathogen. However, anti-infective dose selection is difficult because of the highly abnormal physiologic features of burn patients, which can greatly affect the pharmacokinetic (PK) disposition of these agents. We review published PK data from burn patients and offer evidence-based dosing recommendations for antimicrobial agents in burn-injured patients. Methods: Because most infections occur at least 48 hours after initial burn injury and anti-infective therapy often lasts >= 10 days, we reviewed published data informing PK-pharmacodynamic (PD) dosing of anti-infectives administered during the second, hypermetabolic stage of burn injury, in those with >20% total body surface area burns, and in those with normal or augmented renal clearance (estimated creatinine clearance >= 130 mL/min). Analyses were performed using 10,000 patient Monte Carlo simulations, which uses PK variability observed in burn patients and MIC data to determine the probability of reaching predefined PK-PD targets. The probability of target attainment, defined as the likelihood that an antiinfective dosing regimen would achieve a specific PK-PD target at the single highest susceptible MIC, and the cumulative fraction of response, defined as the population probability of target attainment given a specific dose and a distribution of MICs, were calculated for each recommended anti-infective dosing regimen. Findings: Evidence-based doses were derived for burn-injured patients for 15 antibiotics and 2 antifungal agents. Published data were unavailable or insufficient for several agents important to the care of burn patients, including newer antifungal and antipseudomonal agents. Furthermore, available data suggest that antimicrobial PK properties in burned patients is highly variable. We recommend that, where possible, therapeutic drug monitoring be performed to optimize PK-PD parameter achievement in individual patients. Implications: Given the high variability in PK disposition observed in burn patients, doses recommended in the package insert may not achieve PK-PD parameters associated with optimal infectious outcomes. Our study is limited by the necessity for fixed assumptions in depicting this highly variable patient population. New rapid-turnaround analytical technology is needed to expand the menu of antimicrobial agents for which therapeutic drug monitoring is available to guide dose modification within a clinically actionable time frame. Published by Elsevier HS Journals, Inc. C1 [Cota, Jason M.; FakhriRavari, Alireza] Univ Incarnate Word, Feik Sch Pharm, San Antonio, TX USA. [Rowan, Matthew P.; Chung, Kevin K.; Akers, Kevin S.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Murray, Clinton K.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Akers, KS (reprint author), US Army, Inst Surg Res, JBSA, 3698 Chambers Pass,Ste B, Ft Sam Houston, TX 78234 USA. EM kevin.s.akers.mil@mail.mil FU Defense Medical, Research & Development Program (DMRDP) Military Infectious Disease Clinical Trial Award (MID-CTA) [D_MIDCTA_I_12_J2_299] FX Previous work has been supported by Defense Medical, Research & Development Program (DMRDP) Military Infectious Disease Clinical Trial Award (MID-CTA) D_MIDCTA_I_12_J2_299. NR 99 TC 2 Z9 2 U1 2 U2 2 PU ELSEVIER PI BRIDGEWATER PA 685 ROUTE 202-206, BRIDGEWATER, NJ 08807 USA SN 0149-2918 EI 1879-114X J9 CLIN THER JI Clin. Ther. PD SEP PY 2016 VL 38 IS 9 BP 2016 EP 2031 DI 10.1016/j.clinthera.2016.08.001 PG 16 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA DY3AN UT WOS:000384963300009 PM 27586127 ER PT J AU Jones, FL AF Jones, Frank L. TI ENGAGING THE WORLD: ANTHONY LAKE AND AMERICAN GRAND STRATEGY, 1993-1997 SO HISTORICAL JOURNAL LA English DT Article ID LIBERAL LEGACIES; FOREIGN-AFFAIRS; POLICY; KANT AB Using recently available archival material, this article examines Lake's key beliefs and the part they had in shaping US grand strategy in the first Clinton administration. Lake operated as one of the major architects of the administration's foreign policy. His intellectual influence commenced in the 1992. presidential campaign, when he served as candidate Bill Clinton's principal foreign policy adviser, and continued through the first presidential term, reaching its most concrete manifestation in the Clinton administration's 1994 National security strategy. The article analyses Lake's ideas and his overarching concerns about national purpose, his strategic vision, and his definition of national security policy objectives using the analytical framework known as a mental map. Likewise, it considers his role in articulating a new grand strategy during a period of strategic adjustment, one in which the cold war doctrine of containment no longer applied. C1 [Jones, Frank L.] US Army, Dept Natl Secur & Strategy, War Coll, Carlisle, PA 17015 USA. RP Jones, FL (reprint author), US Army, Dept Natl Secur & Strategy, War Coll, Carlisle, PA 17015 USA. EM frank.l.jones.civ@mail.mil NR 134 TC 0 Z9 0 U1 1 U2 1 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0018-246X EI 1469-5103 J9 HIST J JI Hist. J. PD SEP PY 2016 VL 59 IS 3 BP 869 EP 901 DI 10.1017/S0018246X15000436 PG 33 WC History SC History GA DY0RA UT WOS:000384802700010 ER PT J AU Sugiharto, VA Grieco, JP Murphy, JR Olsen, CH Colacicco-Mayhugh, MG Stewart, VA Achee, NL Turell, MJ AF Sugiharto, Victor A. Grieco, John P. Murphy, Jittawadee R. Olsen, Cara H. Colacicco-Mayhugh, Michelle G. Stewart, V. Ann Achee, Nicole L. Turell, Michael J. TI Effects of Preexposure to DEET on the Downstream Blood-Feeding Behaviors of Aedes aegypti (Diptera: Culicidae) Mosquitoes SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Aedes aegypti; DEET; behavior; blood feeding ID REPELLENTS; SYSTEM; ODOR; CHEMICALS; INSECTS AB Mosquito behavior is heavily influenced by the chemical molecules in the environment. This knowledge can be used to modify insect behaviors; particularly to reduce vector-host contact as a powerful method for disease prevention. N,N-Diethyl-meta-toluamide (DEET) is the most widely used insect repellent in the market and an excellent example of a chemical that has been used to modify insect behavior for disease prevention. However, genetic insensitivity and habituation in Aedes aegypti (L.) mosquitoes after preexposure to DEET have been reported. In this study, we investigated the effect of preexposure to DEET on the downstream blood-feeding behavior of Ae. aegypti mosquitoes and the duration of the effect. We exposed mosquitoes to four different DEET concentrations: 0.10, 0.12, 0.14, and 0.16% for 10 min then allowed the mosquitoes to blood-feed on an artificial blood-feeding system either immediately or after being held for 1, 3, 6, or 24 h following DEET exposure. We found that preexposing Ae. aegypti mosquitoes to 0.14 or 0.16% DEET lowered their blood engorgement level, but did not alter their landing and probing behavior when compared to the control test populations. The reduction in complete blood-feeding was observed at all time periods tested, but was only statistically significant at 3 and 6 h after the preexposure process. Because reduction in blood meal has been associated with increased refeeding, future studies analyzing the effect of this behavior using arbovirus-infected mosquitoes are needed to address the concern of potentially increased vectorial capacity. C1 [Sugiharto, Victor A.; Grieco, John P.; Murphy, Jittawadee R.; Olsen, Cara H.; Stewart, V. Ann; Achee, Nicole L.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biostat, Bethesda, MD 20814 USA. [Grieco, John P.; Achee, Nicole L.] Univ Notre Dame, Eck Inst Global Hlth, Dept Biol Sci, 239 Galvin Life Sci Ctr, Notre Dame, IN 46556 USA. [Colacicco-Mayhugh, Michelle G.] Joint Project Manager Med Countermeasure Syst, Ft Detrick, MD 21702 USA. [Turell, Michael J.] US Army, Dept Vector Assessment, Div Virol, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Sugiharto, VA (reprint author), Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biostat, Bethesda, MD 20814 USA. EM victor.sugiharto@usuhs.edu; jgrieco@nd.edu; jittawadee.murphy@usuhs.edu; cara.olsen@usuhs.edu; michelle.g.colaciccomayhugh.mil@mail.mil; ann.stewart@usuhs.edu; nachee@nd.edu; mturell@erols.com NR 30 TC 0 Z9 0 U1 3 U2 3 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-2585 EI 1938-2928 J9 J MED ENTOMOL JI J. Med. Entomol. PD SEP PY 2016 VL 53 IS 5 BP 1100 EP 1104 DI 10.1093/jme/tjw066 PG 5 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA DW5SV UT WOS:000383708100011 ER PT J AU Higgins, ET Cornwell, JFM AF Higgins, E. Tory Cornwell, James F. M. TI Securing foundations and advancing frontiers: Prevention and promotion effects on judgment & decision making SO ORGANIZATIONAL BEHAVIOR AND HUMAN DECISION PROCESSES LA English DT Article DE Regulatory focus promotion prevention decision making judgment ID THEORY RELATING SELF; REGULATORY FOCUS; GOAL ATTAINMENT; COUNTERFACTUAL THINKING; MORAL PSYCHOLOGY; FEELING RIGHT; FIT; MOTIVATION; AVOIDANCE; PERSUASION AB Over the past two decades, research testing regulatory focus theory has made multiple contributions to understanding better many different psychological issues. In this article, we detail the foundations of regulatory focus theory, its wide-ranging impact, and its implications in particular for understanding the motivational underpinnings of judgment and decision making. We then explore new developments regarding the interactions between regulatory focus and the psychological experience of being above or below the status quo, and note how this research helps to further distinguish regulatory focus from more general models of approach-avoidance. We then close with a discussion of new research on the relation among regulatory focus, politics, and culture, and between regulatory focus and ethics both of which may be of special interest to organizational psychologists and decision scientists. (C) 2016 Elsevier Inc. All rights reserved. C1 [Higgins, E. Tory; Cornwell, James F. M.] Columbia Univ, Dept Psychol, 406 Schermerhorn Hall,1190 Amsterdam Ave MC 5501, New York, NY 10027 USA. [Cornwell, James F. M.] US Mil Acad, Dept Behav Sci & Leadership, 276 Thayer Hall, West Point, NY 10996 USA. RP Higgins, ET (reprint author), Columbia Univ, Dept Psychol, 406 Schermerhorn Hall,1190 Amsterdam Ave MC 5501, New York, NY 10027 USA. EM tory@psych.columbia.edu; jamesfcornwell@gmail.com NR 89 TC 0 Z9 0 U1 17 U2 17 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0749-5978 EI 1095-9920 J9 ORGAN BEHAV HUM DEC JI Organ. Behav. Hum. Decis. Process. PD SEP PY 2016 VL 136 BP 56 EP 67 DI 10.1016/j.obhdp.2016.04.005 PG 12 WC Psychology, Applied; Management; Psychology, Social SC Psychology; Business & Economics GA DY1MI UT WOS:000384858700007 ER PT J AU Papa, A Vaheri, A LeDuc, JW Kruger, DH Avsic-Zupanc, T Arikawa, J Song, JW Markotic, A Clement, J Liang, MF Li, DX Yashina, LN Jonsson, CB Schmaljohn, CS AF Papa, Anna Vaheri, Antti LeDuc, James W. Krueger, Detlev H. Avsic-Zupanc, Tatjana Arikawa, Jiro Song, Jin-Won Markotic, Alemka Clement, Jan Liang, Mifang Li, Dexin Yashina, Liudmila N. Jonsson, Colleen B. Schmaljohn, Connie S. TI Meeting report: Tenth International Conference on Hantaviruses SO ANTIVIRAL RESEARCH LA English DT Article DE Hantavirus; Hemorrhagic fever with renal syndrome; Hantavirus pulmonary syndrome ID RECEPTOR ANTAGONIST ICATIBANT; HEMORRHAGIC-FEVER; DISEASE SEVERITY; RENAL SYNDROME; INFECTION; VIRUS; PATHOGENESIS; RESPONSES; RODENTS; AFRICA AB The 10th International Conference on Hantaviruses, organized by the International Society on Hantaviruses, was held from May 31-June 3, 2016 at Colorado State University, Fort Collins, CO, USA. These conferences have been held every three years since 1980. The current report summarizes research presented on all aspects of hantavirology: ecology and epidemiology, virus replication, phylogeny, pathogenesis, immune response, clinical studies, vaccines and therapeutics. (C) 2016 Elsevier B.V. All rights reserved. C1 [Papa, Anna] Aristotle Univ Thessaloniki, Sch Med, Dept Microbiol, Thessaloniki, Greece. [Vaheri, Antti] Univ Helsinki, Dept Virol, Fac Med, Helsinki, Finland. [LeDuc, James W.] Univ Texas Med Branch, Galveston Natl Lab, Galveston, TX 77555 USA. [Krueger, Detlev H.] Univ Hosp Charite, Inst Med Virol, Berlin, Germany. [Avsic-Zupanc, Tatjana] Univ Ljubljana, Fac Med, Inst Microbiol & Immunol, Ljubljana, Slovenia. [Arikawa, Jiro] Hokkaido Univ, Grad Sch Med, Dept Microbiol, Sapporo, Hokkaido, Japan. [Song, Jin-Won] Korea Univ, Coll Med, Dept Microbiol, Seoul, South Korea. [Markotic, Alemka] Univ Hosp Infect Dis Dr Fran Mihaljevic, Res Dept, Zagreb, Croatia. [Clement, Jan] Univ Leuven, Lab Clin & Epidemiol Virol, Leuven, Belgium. [Clement, Jan] Univ Leuven, Rega Inst Med Res, Leuven, Belgium. [Liang, Mifang; Li, Dexin] China CDC, Natl Inst Viral Dis Control & Prevent, Beijing, Peoples R China. [Yashina, Liudmila N.] State Res Ctr Virol & Biotechnol Vector, Koltsov, Russia. [Jonsson, Colleen B.] Univ Tennessee, Dept Microbiol, Knoxville, TN 37996 USA. [Schmaljohn, Connie S.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Papa, A (reprint author), Aristotle Univ Thessaloniki, Sch Med, Dept Microbiol, Thessaloniki, Greece. EM annap@med.auth.gr FU National Institutes of Health [1R13AI124621-01] FX We thank all participants who presented their data during the 10th International Conference on Hantaviruses. We are thankful to Richard Yanagihara for the constructive comments and Tony Schountz, the local organizer from Colorado State University, for the excellent organization of the conference. Support for the conference was provided in part by National Institutes of Health grant 1R13AI124621-01 to C.B.J. NR 29 TC 1 Z9 1 U1 3 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 EI 1872-9096 J9 ANTIVIR RES JI Antiviral Res. PD SEP PY 2016 VL 133 BP 234 EP 241 DI 10.1016/j.antiviral.2016.08.015 PG 8 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA DY1LJ UT WOS:000384856200027 PM 27544703 ER PT J AU Kallberg, J AF Kallberg, Jan TI Humanitarian Cyber Operations SO IEEE TECHNOLOGY AND SOCIETY MAGAZINE LA English DT Article; Proceedings Paper CT IEEE International Symposium on Technology and Society (ISTAS) CY NOV 11-12, 2015 CL Dublin, IRELAND SP IEEE C1 [Kallberg, Jan] US Mil Acad, Army Cyber Inst West Point, Spellman Hall 4-33,2101 New South Post Rd, West Point, NY 10996 USA. RP Kallberg, J (reprint author), US Mil Acad, Army Cyber Inst West Point, Spellman Hall 4-33,2101 New South Post Rd, West Point, NY 10996 USA. EM jan.kallberg@usma.edu NR 9 TC 0 Z9 0 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0278-0097 EI 1937-416X J9 IEEE TECHNOL SOC MAG JI IEEE Technol. Soc. Mag. PD SEP PY 2016 VL 35 IS 3 SI SI BP 81 EP 85 DI 10.1109/MTS.2016.2599209 PG 5 WC Engineering, Electrical & Electronic SC Engineering GA DX2WX UT WOS:000384234900017 ER PT J AU Hobson, DW Schuh, JCL Zurawski, DV Wang, JY Arbabi, S McVean, M Funk, KA AF Hobson, David W. Schuh, JoAnn C. L. Zurawski, Daniel V. Wang, Jianyong Arbabi, Sam McVean, Maralee Funk, Kathleen A. TI The First Cut Is the Deepest: The History and Development of Safe Treatments for Wound Healing and Tissue Repair SO INTERNATIONAL JOURNAL OF TOXICOLOGY LA English DT Article DE wound healing; tissue repair; skin injury ID EXTENSIVELY DRUG-RESISTANT; ACINETOBACTER-BAUMANNII; ANIMAL-MODELS; INFLAMMATION AB As the skin is the primary barrier to infection, the importance of wound healing has been understood since ancient times. This article provides a synopsis on the symposium presentations focusing on how wounds were traditionally treated, what models and pathology endpoints exist to study wound healing, special considerations for wound healing studies, an overview of regulatory aspects of new pharmaceutical and medical device development, and the clinical relevance of such models. The clinical treatment of small and large wounds is also considered. C1 [Hobson, David W.] LoneStar PharmTox LLC, Bergheim, TX USA. [Schuh, JoAnn C. L.] JCL Schuh PLLC, Bainbridge Isl, WA USA. [Zurawski, Daniel V.] Walter Reed Army Inst Res, Bacterial Dis Branch, Wound Infect Dept, Silver Spring, MD USA. [Wang, Jianyong] US FDA, DDDP, OND, CDER, Silver Spring, MD USA. [Arbabi, Sam] Univ Washington, Seattle, WA 98195 USA. [McVean, Maralee] PreClin Res Serv Inc, Ft Collins, CO USA. [Funk, Kathleen A.] Expt Pathol Labs Inc, Sterling, VA USA. RP Funk, KA (reprint author), Expt Pathol Labs, 45600 Terminal Dr, Sterling, VA 20166 USA. EM kfunk@epl-inc.com RI Zurawski, Daniel/B-6578-2009 OI Zurawski, Daniel/0000-0002-7920-5601 FU Military Infectious Diseases Research Program (MIDRP); Defense Medical Research and Development Program (DMRDP) FX Daniel V. Zurawski would like to acknowledge his support by the Military Infectious Diseases Research Program (MIDRP) and the Defense Medical Research and Development Program (DMRDP). NR 34 TC 0 Z9 0 U1 1 U2 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1091-5818 EI 1092-874X J9 INT J TOXICOL JI Int. J. Toxicol. PD SEP-OCT PY 2016 VL 35 IS 5 BP 491 EP 498 DI 10.1177/1091581816656804 PG 8 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA DX5TL UT WOS:000384444900001 PM 27402775 ER PT J AU Shaw, LJ Villines, T Leipsic, J AF Shaw, Leslee J. Villines, Todd Leipsic, Jonathon TI Stepping stones, milestones, and obstructing boulders SO JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY LA English DT Editorial Material C1 [Shaw, Leslee J.] Emory Univ, Sch Med, Atlanta, GA USA. Walter Reed Army Med Ctr, Bethesda, MD USA. Univ British Columbia, Providence Hlth Care, Vancouver, BC, Canada. RP Shaw, LJ (reprint author), Emory Univ, Sch Med, Emory Clin Cardiovasc Res Inst, Room 529,1462 Clifton Rd NE, Atlanta, GA 30322 USA. EM lshaw3@emory.edu NR 2 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1934-5925 J9 J CARDIOVASC COMPUT JI J. Cardiovasc. Comput. Tomogr. PD SEP-OCT PY 2016 VL 10 IS 5 BP 433 EP 434 DI 10.1016/j.jcct.2016.08.005 PG 2 WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical Imaging SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine & Medical Imaging GA DY0JR UT WOS:000384783600016 PM 27528430 ER PT J AU Dubick, MA Pusateri, AE AF Dubick, Michael A. Pusateri, Anthony E. TI WHAT'S NEW IN SHOCK, MILITARY SUPPLEMENT SEPTEMBER 2016 SO SHOCK LA English DT Editorial Material C1 [Dubick, Michael A.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA. [Pusateri, Anthony E.] US Army Med Res Mat Command, Combat Casualty Care Res Program, Ft Detrick, MD USA. RP Dubick, MA (reprint author), US Army Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA. EM Michael.a.dubick.civ@mail.mil NR 24 TC 0 Z9 0 U1 3 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD SEP PY 2016 VL 46 IS 3 SU 1 BP 1 EP 3 DI 10.1097/SHK.0000000000000705 PG 3 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DX3HG UT WOS:000384263600001 PM 27496598 ER PT J AU Kottke, MA Walters, TJ AF Kottke, Melissa A. Walters, Thomas J. TI WHERE'S THE LEAK IN VASCULAR BARRIERS? A REVIEW SO SHOCK LA English DT Review DE Barrier; basement membrane; edema; endothelial cell; glycocalyx; pericyte ID PLATELET-ACTIVATING-FACTOR; ENDOTHELIAL GROWTH-FACTOR; INDUCED LUNG INJURY; RESPIRATORY-DISTRESS-SYNDROME; DAMAGE-CONTROL RESUSCITATION; FOCAL ADHESION KINASE; FRESH-FROZEN PLASMA; MICROVASCULAR FLUID EXCHANGE; CAPILLARY BASEMENT-MEMBRANE; ISCHEMIA-REPERFUSION INJURY AB Edema is typically presented as a secondary effect from injury, illness, disease, or medication, and its impact on patient wellness is nested within the underlying etiology. Therefore, it is often thought of more as an amplifier to current preexisting conditions. Edema, however, can be an independent risk factor for patient deterioration. Improper management of edema is costly not only to the patient, but also to treatment and care facilities, as mismanagement of edema results in increased lengths of hospital stay. Direct tissue trauma, disease, or inappropriate resuscitation and/or ventilation strategies result in edema formation through physical disruption and chemical messenger-based structural modifications of the microvascular barrier. Derangements in microvascular barrier function limit tissue oxygenation, nutrient flow, and cellular waste removal. Recent studies have sought to elucidate cellular signaling and structural alterations that result in vascular hyperpermeability in a variety of critical care conditions to include hemorrhage, burn trauma, and sepsis. These studies and many others have highlighted how multiple mechanisms alter paracellular and/or transcellular pathways promoting hyperpermeability. Roles for endothelial glycocalyx, extracellular matrix and basement membrane, vesiculo-vacuolar organelles, cellular junction and cytoskeletal proteins, and vascular pericytes have been described, demonstrating the complexity of microvascular barrier regulation. Understanding these basic mechanisms inside and out of microvessels aid in developing better treatment strategies to mitigate the harmful effects of excessive edema formation. C1 [Kottke, Melissa A.; Walters, Thomas J.] US Army Inst Surg Res, Extrem Trauma & Regenerat Med Res Program, Ft Sam Houston, TX USA. RP Kottke, MA (reprint author), US Army Inst Surg Res, 3698 Chambers Pass,Bldg 3611, Jbsa Ft Sam Houston, TX 78234 USA. EM melissa.a.kottke.mil@mail.mil NR 212 TC 2 Z9 2 U1 5 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD SEP PY 2016 VL 46 IS 3 SU 1 BP 20 EP 36 DI 10.1097/SHK.0000000000000666 PG 17 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DX3HG UT WOS:000384263600004 PM 27405062 ER PT J AU Poh, PYS Gagnon, D Romero, SA Convertino, VA Adams-Huet, B Crandall, CG AF Poh, Paula Y. S. Gagnon, Daniel Romero, Steven A. Convertino, Victor A. Adams-Huet, Beverley Crandall, Craig G. TI HEMODYNAMIC STABILITY TO SURFACE WARMING AND COOLING DURING SUSTAINED AND CONTINUOUS SIMULATED HEMORRHAGE IN HUMANS SO SHOCK LA English DT Article DE Cerebral perfusion; compensatory reserve index; lower body negative pressure; mean arterial pressure; skin surface warming and cooling ID DYNAMIC CEREBRAL AUTOREGULATION; IMPROVES ORTHOSTATIC TOLERANCE; PASSIVE HEAT-STRESS; BLOOD-PRESSURE; TRAUMA PATIENTS; HYPOTHERMIA; FLOW; VELOCITY; MODEL; SHOCK AB One in 10 deaths worldwide is caused by traumatic injury, and 30% to 40% of those trauma-related deaths are due to hemorrhage. Currently, warming a bleeding victim is the standard of care due to the adverse effects of combined hemorrhage and hypothermia on survival. We tested the hypothesis that heating is detrimental to the maintenance of arterial pressure and cerebral perfusion during hemorrhage, while cooling is beneficial to victims who are otherwise normothermic. Twenty-one men (31 +/- 9 y) were examined under two separate protocols designed to produce central hypovolemia similar to hemorrhage. Following 15 min of supine rest, 10 min of 30 mm Hg of lower body negative pressure (LBNP) was applied. On separate randomized days, subjects were then exposed to skin surface cooling (COOL), warming (WARM), or remained thermoneutral (NEUT), while LBNP continued. Subjects remained in these thermal conditions for either 40 min of 30 mmHg LBNP (N = 9), or underwent a continuous LBNP ramp until hemodynamic decompensation (N = 12). Arterial blood pressure during LBNP was dependent on the thermal perturbation as blood pressure was greater during COOL (P>0.001) relative to NEUT and WARM for both protocols. Middle cerebral artery blood velocity decreased (P<0.001) from baseline throughout sustained and continuous LBNP, but the magnitude of reduction did not differ between thermal conditions. Contrary to our hypothesis, WARM did not reduce cerebral blood velocity or LBNP tolerance relative to COOL and NEUT in normothermic individuals. While COOL increased blood pressure, cerebral perfusion and time to presyncope were not different relative to NEUT or WARM during sustained or continuous LBNP. Warming an otherwise normothermic hemorrhaging victim is not detrimental to hemodynamic stability, nor is this stability improved with cooling. C1 [Poh, Paula Y. S.; Gagnon, Daniel; Romero, Steven A.; Crandall, Craig G.] Texas Hlth Presbyterian Hosp, Inst Exercise & Environm Med, Dallas, TX USA. [Poh, Paula Y. S.; Gagnon, Daniel; Romero, Steven A.; Crandall, Craig G.] UT Southwestern Med Ctr, Dallas, TX USA. [Convertino, Victor A.] US Army Inst Surg Res, Tact Combat Casualty Care, Ft Sam Houston, TX USA. [Adams-Huet, Beverley] UT Southwestern Med Ctr, Dept Clin Sci, Dallas, TX USA. [Adams-Huet, Beverley] UT Southwestern Med Ctr, Dept Internal Med, Dallas, TX USA. RP Crandall, CG (reprint author), Texas Hlth Presbyterian Hosp Dallas, Inst Exercise & Environm Med, 7232 Greenville Ave, Dallas, TX 75231 USA. EM craigcrandall@texashealth.org OI Gagnon, Daniel/0000-0001-5396-9489 FU NIGMS NIH HHS [R01 GM068865] NR 34 TC 1 Z9 1 U1 2 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD SEP PY 2016 VL 46 IS 3 SU 1 BP 42 EP 49 DI 10.1097/SHK.0000000000000661 PG 8 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DX3HG UT WOS:000384263600006 PM 27224744 ER PT J AU Howard, JT Janak, JC Hinojosa-Laborde, C Convertino, VA AF Howard, Jeffrey T. Janak, Jud C. Hinojosa-Laborde, Carmen Convertino, Victor A. TI SPECIFICITY OF COMPENSATORY RESERVE AND TISSUE OXYGENATION AS EARLY PREDICTORS OF TOLERANCE TO PROGRESSIVE REDUCTIONS IN CENTRAL BLOOD VOLUME SO SHOCK LA English DT Article DE Blood loss; compensatory reserve; hemorrhage; hypovolemia; near infrared spectroscopy; pH; prehospital; tissue oxygen saturation; triage; vasoconstriction ID BODY NEGATIVE-PRESSURE; NEAR-INFRARED SPECTROSCOPY; CENTRAL HYPOVOLEMIA; HEMORRHAGIC-SHOCK; EARLY INDICATOR; SATURATION; HUMANS; INDEX; VALIDATION; TRAUMA AB We previously reported that measurements of muscle oxygen saturation (SmO2) and the compensatory reserve index (CRI) provided earlier indication of reduced central blood volume than standard vital signs (e.g., blood pressure, heart rate, arterial oxygen saturation). In the present study, we hypothesized that the CRI would provide greater sensitivity and specificity to detect progressive decrease in central circulating blood volume compared with SmO2. Continuous noninvasive measures of CRI (calculated from feature changes in the photoplethysmographic arterial waveforms) were collected from 55 healthy volunteer subjects before and during stepwise lower body negative pressure (LBNP) to the onset of hemodynamic decompensation. Near infrared spectroscopy was used on the forearm to obtain deep SmO2, hydrogen ion concentration ([H+]), and hemoglobin volume (HbT; decreases reflect vasoconstriction). CRI decreased by 97% in a linear fashion across progressive blood volume loss, with no clinically significant alterations in vital signs. The receiver operating characteristic (ROC) area under the curve (AUC) for the CRI was 0.91, with a sensitivity of 0.87 and specificity of 0.80, when predicting decompensation at progressive levels of LBNP. In comparison, SmO2, [H+], and HbT had significantly lower ROC AUC, sensitivity and specificity values for detecting the same outcome. Consistent with our hypothesis, CRI detected central hypovolemia with significantly greater specificity than measures of tissue metabolism. Single measurement of CRI may enable more accurate triage, while CRI monitoring may allow for earlier detection of casualty deterioration. C1 [Howard, Jeffrey T.; Janak, Jud C.; Hinojosa-Laborde, Carmen; Convertino, Victor A.] US Army Inst Surg Res, San Antonio, TX USA. RP Howard, JT (reprint author), 3698 Chambers Pass,Bldg 3611, San Antonio, TX 78234 USA. EM jeffrey.t.howard13.vol@mail.mil NR 29 TC 1 Z9 1 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD SEP PY 2016 VL 46 IS 3 SU 1 BP 68 EP 73 DI 10.1097/SHK.0000000000000632 PG 6 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DX3HG UT WOS:000384263600010 PM 27058052 ER PT J AU Gagnon, D Schlader, ZJ Adams, A Rivas, E Mulligan, J Grudic, GZ Convertino, VA Howard, JT Crandall, CG AF Gagnon, Daniel Schlader, Zachary J. Adams, Amy Rivas, Eric Mulligan, Jane Grudic, Gregory Z. Convertino, Victor A. Howard, Jeffrey T. Crandall, Craig G. TI THE EFFECT OF PASSIVE HEAT STRESS AND EXERCISE-INDUCED DEHYDRATION ON THE COMPENSATORY RESERVE DURING SIMULATED HEMORRHAGE SO SHOCK LA English DT Article DE Compensatory reserve; dehydration; exercise; heat; hemorrhage ID PROGRESSIVE CENTRAL HYPOVOLEMIA; COMBAT CASUALTY CARE; GENERALIZED ESTIMATING EQUATIONS; LONGITUDINAL DATA-ANALYSIS; BODY NEGATIVE-PRESSURE; BLOOD-LOSS; INDUSTRIAL-WORKERS; THERMAL-STRESS; INDEX; EPIDEMIOLOGY AB Compensatory reserve represents the proportion of physiological responses engaged to compensate for reductions in central blood volume before the onset of decompensation. We hypothesized that compensatory reserve would be reduced by hyperthermia and exercise-induced dehydration, conditions often encountered on the battlefield. Twenty healthy males volunteered for two separate protocols during which they underwent lower-body negative pressure (LBNP) to hemodynamic decompensation (systolic blood pressure <80 mm Hg). During protocol #1, LBNP was performed following a passive increase in core temperature of similar to 1.2 degrees C (HT) or a normothermic time-control period (NT). During protocol #2, LBNP was performed following exercise during which: fluid losses were replaced (hydrated), fluid intake was restricted and exercise ended at the same increase in core temperature as hydrated (isothermic dehydrated), or fluid intake was restricted and exercise duration was the same as hydrated (time-match dehydrated). Compensatory reserve was estimated with the compensatory reserve index (CRI), a machine-learning algorithm that extracts features from continuous photoplethysmograph signals. Prior to LBNP, CRI was reduced by passive heating [NT: 0.87 (SD 0.09) vs. HT: 0.42 (SD 0.19) units, P<0.01] and exercise-induced dehydration [hydrated: 0.67 (SD 0.19) vs. isothermic dehydrated: 0.52 (SD 0.21) vs. time-match dehydrated: 0.47 (SD 0.25) units; P < 0.01 vs. hydrated]. During subsequent LBNP, CRI decreased further and its rate of change was similar between conditions. CRI values at decompensation did not differ between conditions. These results suggest that passive heating and exercise-induced dehydration limit the body's physiological reserve to compensate for further reductions in central blood volume. C1 [Gagnon, Daniel; Adams, Amy; Crandall, Craig G.] Texas Hlth Presbyterian Hosp Dallas, Inst Exercise & Environm Med, 7232 Greenville Ave, Dallas, TX 75231 USA. [Gagnon, Daniel; Adams, Amy; Crandall, Craig G.] Univ Texas Southwestern Med Ctr Dallas, Dallas, TX 75390 USA. [Schlader, Zachary J.] SUNY Buffalo, Dept Exercise & Nutr Sci, Buffalo, NY USA. [Rivas, Eric] Univ Calif Irvine, Inst Clin & Translat Sci, Irvine, CA USA. [Rivas, Eric] Univ Calif Irvine, Dept Pediat, Irvine, CA 92717 USA. [Mulligan, Jane; Grudic, Gregory Z.] Flashback Technol Inc, Boulder, CO USA. [Convertino, Victor A.; Howard, Jeffrey T.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX USA. RP Crandall, CG (reprint author), Texas Hlth Presbyterian Hosp Dallas, Inst Exercise & Environm Med, 7232 Greenville Ave, Dallas, TX 75231 USA. EM craigcrandall@texashealth.org OI Rivas, Eric/0000-0002-4657-8292; Gagnon, Daniel/0000-0001-5396-9489 NR 34 TC 1 Z9 1 U1 2 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD SEP PY 2016 VL 46 IS 3 SU 1 BP 74 EP 82 DI 10.1097/SHK.0000000000000653 PG 9 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DX3HG UT WOS:000384263600011 PM 27183303 ER PT J AU Wu, XW Schwacha, MG Dubick, MA Cap, AP Darlington, DN AF Wu, Xiaowu Schwacha, Martin G. Dubick, Michael A. Cap, Andrew P. Darlington, Daniel N. TI TRAUMA-RELATED ACUTE LUNG INJURY DEVELOPS RAPIDLY IRRESPECTIVE OF RESUSCITATION STRATEGY IN THE RAT SO SHOCK LA English DT Article DE Hemorrhage; monocytes; neutrophils; platelets; polytrauma; resuscitation ID COMBAT CASUALTY CARE; BLOOD-VOLUME; TRANSFUSION; HEMORRHAGE; COAGULOPATHY; MODELS; DYSFUNCTION; MORTALITY; PLATELETS; DEATHS AB Background: Acute lung injury (ALI) has been observed clinically after severe trauma. We have recently developed a rat model of polytrauma that shows evidence of multi-organ failure and coagulopathy. In this study, we investigate whether ALI occurs after severe trauma and resuscitation, and the cellular mechanisms involved. Methods: Polytrauma and hemorrhage was induced in anesthetized Sprague-Dawley rats. Five groups were prepared: control, no resuscitation, and resuscitation with Lactated Ringer (LR), fresh whole blood or whole blood stored 7days at 4 degrees C. Resuscitation was begun 1 hr after trauma. Lung injury was determined by lung wet/dry weight ratios. Results: Polytrauma and hemorrhage (no resuscitation) led to a significant increase in the number of neutrophils, monocytes, macrophages, platelets, and the levels of myeloperoxidase, pro-inflammatory cytokines (IL-6, IL-1 alpha, IL-1 beta), anti-inflammatory Th2 cytokines (IL-4, IL-10, IL-13), and chemokines (MIP-1a, GRO KC) in the lung tissue. Resuscitation with LR, fresh whole blood or stored blood led to a significant change in the lung wet/dry ratio signifying fluid movement into the lungs. However, fluid did not move into the lungs in non-resuscitated controls. Conclusion: This study shows that trauma related acute lung injury occurs early after polytrauma and hemorrhage in rat. This ALI is secondary to the trauma, and likely due to an elevation in leukocytes, platelets, inflammatory cytokines and myeloperoxidase in the lung tissue prior to any resuscitation. Resuscitation with either LR or whole blood demonstrated similar lung edema. Blood was neither more protective nor more damaging than LR during early resuscitation. C1 US Army Inst Surg Res, Coagulat & Blood Res Program, Ft Sam Houston, TX USA. Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA. RP Wu, XW (reprint author), US Army Inst Surg Res, 3650 Chambers Pass,Bldg 3610, Jbsa Ft Sam Houston, TX 78234 USA. EM xiaowu.wu.civ@mail.mil; schwacha@uthscsa.edu; Michael.a.dubick.civ@mail.mil; andrew.p.cap.mil@mail.mil; daniel.n.darlington.civ@mail.mil NR 32 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD SEP PY 2016 VL 46 IS 3 SU 1 BP 108 EP 114 DI 10.1097/SHK.0000000000000652 PG 7 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DX3HG UT WOS:000384263600016 PM 27172150 ER PT J AU Vernon, PJ Paredes, RM Sooter, AJ Schaub, LJ Grossman, HM Pusateri, AE Glaser, JJ Sheppard, FR AF Vernon, Philip J. Paredes, Ruth Madelaine Sooter, Amanda J. Schaub, Leasha J. Grossman, Heather M. Pusateri, Anthony E. Glaser, Jacob J. Sheppard, Forest R. TI SEVERE HEMORRHAGIC SHOCK INDUCES ACUTE ACTIVATION AND EXPANSION OF IL-8+/IL-10+NEUTROPHILS WITH ENHANCED OXIDATIVE REACTIVITY IN NON-HUMAN PRIMATES SO SHOCK LA English DT Article DE Cytokine; hemorrhage; neutrophil; non-human primate (NHP); oxidative burst capacity; ROS; shock ID MULTIPLE ORGAN FAILURE; ACUTE LUNG INJURY; STERILE INFLAMMATION; NEUTROPHILS; MECHANISMS; RESUSCITATION; INFECTION; IMMUNITY AB Background: Neutrophilic inflammation is a mediator of morbidity and mortality in response to hemorrhagic shock. Although injury-induced neutrophil margination has long been observed, the nature of neutrophils' role in the "second hit'' paradigm remains to be fully elucidated. We sought to extensively characterize neutrophil phenotype and functionality in response to severe hemorrhage in non-human primates (NHPs). Methods: NHPs (n = 8) were subjected to severe hemorrhagic shock and resuscitation. Blood was obtained at baseline (T = 0 min), end of shock (T = 60 min), end of resuscitation (T = 180 min), T = 360 min, and 24 h (T = 1440 min). Neutrophils were quantified by complete blood count and flow cytometry. IL-8 and IL-10 production was determined by intracellular flow cytometry. Oxidation of dihydrorhodamine-123 (DHR-123) was used to determine neutrophil oxidative bursts (untreated), priming (+fMLP), and burst capacity (+PMA/ionomycin) via microplate reader ex vivo. Data are reported as mean +/- SEM; statistical significance was measured using repeated measures ANOVA with Bonferroni adjustment. P<0.05 is considered significant. Results: CD45(+)CD11b(+)CD16(+) neutrophils doubled postinjury (P<0.0001); this was due to activated IL-8+/IL-10+ neutrophils that increased in frequency in relation to resting IL-8(lo) IL-10(neg) cells. At 24 h, the proportions of activated to resting neutrophils returned to baseline levels. Resuscitative measures initially decreased neutrophil oxidative output; however, oxidative bursts, priming, and burst capacity were significantly increased at 24 h (P<0.0025, 0.0124, and 0.0118, respectively). Conclusion: These results demonstrate an acute expansion and phenotypic activation of circulating neutrophils postinjury followed by a return to homeostatic proportions within 24 h; paradoxically, phenotypically "resting'' neutrophils at 24 h have significantly higher oxidative potential, predisposing for exaggerated inflammatory responses. These data are consistent with clinical literature and provide important functional insight into neutrophil-mediated shock pathology. C1 [Vernon, Philip J.; Paredes, Ruth Madelaine; Sooter, Amanda J.; Schaub, Leasha J.; Grossman, Heather M.; Glaser, Jacob J.; Sheppard, Forest R.] Naval Med Res Unit San Antonio, 4141 Petr Dr BLDG 3260, Jbsa Ft Sam Houston, TX 78234 USA. [Pusateri, Anthony E.] US Army Med Res & Mat Command, Ft Detrick, MD USA. RP Sheppard, FR (reprint author), Naval Med Res Unit San Antonio, 4141 Petr Dr BLDG 3260, Jbsa Ft Sam Houston, TX 78234 USA. EM Forest.r.sheppard.mil@mail.mil NR 35 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD SEP PY 2016 VL 46 IS 3 SU 1 BP 129 EP 136 DI 10.1097/SHK.0000000000000643 PG 8 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DX3HG UT WOS:000384263600019 PM 27206276 ER PT J AU Burmeister, DM McIntyre, MK Baker, BA Rizzo, JA Brown, A Natesan, S Chung, KK Christy, RJ AF Burmeister, David M. McIntyre, Matthew K. Baker, Bryan A. Rizzo, Julie A. Brown, Ammon Natesan, Shanmugasundaram Chung, Kevin K. Christy, Robert J. TI IMPACT OF ISOLATED BURNS ON MAJOR ORGANS: A LARGE ANIMAL MODEL CHARACTERIZED SO SHOCK LA English DT Article DE Burns; cytokines; swine; systemic inflammation ID RESPIRATORY-DISTRESS-SYNDROME; ASSOCIATION SEPSIS CRITERIA; INTENSIVE-CARE-UNIT; HEPATIC BLOOD-FLOW; ACUTE LUNG INJURY; OXYGEN-CONSUMPTION; INHALATION INJURY; SMOKE-INHALATION; PORCINE MODEL; SYSTEMIC INFLAMMATION AB Severe burn results in systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction (MOD). Currently, large-animal models of burn-induced SIRS/MOD mostly use secondary insults resulting in a paucity of knowledge on the effect of burn alone on different organ systems. The objective of the current study was to develop and characterize a large animal model of burn-induced SIRS over the course of 2 weeks. Yorkshire swine (n = 16) were randomized to sham controls (n = 4) or 40% total body surface area contact burns (n = 6 at 2 and 14 days post-burn). Blood chemistry and complete blood count analyses were performed at baseline and post-burn days 1, 2, 3, 7, 10, and 14. Upon euthanasia, tissue samples were taken for histopathology. Burns were found to be full thickness and did not re-epithelialize. SIRS was evidenced by increased body temperature, respiration rate, pulse, and white blood cell count for the duration of the experiment. Both acute liver injury and acute kidney injury were induced as determined biochemically and histologically. Histology also revealed atelectasis of the lungs which was associated with increased myeloperoxidase activity. Intestinal structure as well as enterocyte homeostasis was also disrupted. All of these organ abnormalities recovered to varying degrees by 14 days post-burn. We report a unique reproducible large animal model of burn-induced SIRS that can be tailored to specific organ systems for investigation into potential immunomodulatory interventions that prevent organ failure or promote organ recovery after burn injury. C1 [Burmeister, David M.; McIntyre, Matthew K.; Baker, Bryan A.; Rizzo, Julie A.; Brown, Ammon; Natesan, Shanmugasundaram; Chung, Kevin K.; Christy, Robert J.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Rizzo, Julie A.; Chung, Kevin K.] Univ Hlth Sci, Uniformed Hlth Serv, Bethesda, MD USA. RP Christy, RJ (reprint author), US Army Inst Surg Res, Combat Trauma & Burn Injury Res, 3698 Chambers Pass,BHT1 Bldg 3611, Ft Sam Houston, TX 78234 USA. EM robert.j.christy12.civ@mail.mil OI Natesan, Shanmugasundaram/0000-0003-4213-3111 NR 49 TC 1 Z9 1 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD SEP PY 2016 VL 46 IS 3 SU 1 BP 137 EP 147 DI 10.1097/SHK.0000000000000662 PG 11 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DX3HG UT WOS:000384263600020 PM 27380531 ER PT J AU Kheirabadi, BS Terrazas, IB Miranda, N Voelker, AN Grimm, R Kragh, JF Dubick, MA AF Kheirabadi, Bijan S. Terrazas, Irasema B. Miranda, Nahir Voelker, Amber N. Grimm, Rose Kragh, John F., Jr. Dubick, Michael A. TI PHYSIOLOGICAL CONSEQUENCES OF ABDOMINAL AORTIC AND JUNCTIONAL TOURNIQUET (AAJT) APPLICATION TO CONTROL HEMORRHAGE IN A SWINE MODEL SO SHOCK LA English DT Article DE Abdominal aortic and junctional tourniquet; hemorrhage control; junctional bleeding; junctional tourniquet; swine AB Introduction: Specialized tourniquets such as Abdominal Aortic and Junctional Tourniquet (AAJT) have been deployed for control of junctional hemorrhage with limited information concerning their efficacy and safety. We examined physiological effects of a 2-h abdominal application of AAJT to control groin hemorrhage in a swine model. Methods: Anesthetized pigs were subjected to 25% controlled hemorrhage and a groin arterial injury. Resulting hemorrhage from the groin wound was controlled for 2 h by applying AAJT on each pig's abdomen. After AAJT removal, the artery was repaired and blood flow was fully restored for 1 h. CTangiography and blood analyses were done and tissues collected for histology. Experiments were conducted in three groups of pigs (n = 6/group): mechanically ventilated (MV); spontaneously breathing (SB); and spontaneously breathing during AAJT application but transitioned to mechanical ventilation (SB-MV) before AAJT release. Results: AAJT application produced sharp increases in blood pressure and heart rate. SB animals experienced labored and rapid respiration, but their PaO2 and PaCO2 were unaffected. Their respiration suddenly stopped when the AAJT was released requiring manual respiratory assistance. However, three pigs in SB group eventually died from cardiac and respiratory arrests, which coincided with hyperkalemia and metabolic acidosis that occurred after reflow. These changes were less severe in other groups. Other measures including increased hematocrit, tissue injury biomarkers, and kidney function indicators were similar in all groups. Histological changes were mild and reversible. Conclusion: The ischemia-induced hyperkalemia and metabolic acidosis associated with AAJT application are life-threatening in spontaneously breathing subjects. Cardiopulmonary resuscitation appears necessary when AAJT is released to prevent life-threatening consequences. C1 [Kheirabadi, Bijan S.; Terrazas, Irasema B.; Miranda, Nahir; Voelker, Amber N.; Grimm, Rose; Kragh, John F., Jr.; Dubick, Michael A.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA. RP Kheirabadi, BS (reprint author), 3650 Chambers Pass,BHT2,Bldg 3610, Jbsa Ft Sam Houston, TX 78234 USA. EM bijan.s.kheirabadi.civ@mail.mil NR 15 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD SEP PY 2016 VL 46 IS 3 SU 1 BP 160 EP 166 DI 10.1097/SHK.0000000000000651 PG 7 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DX3HG UT WOS:000384263600023 PM 27172149 ER PT J AU Campbell, JC Li, YS van Amersfoort, E Relan, A Dubick, M Sheppard, F Pusateri, A Niemeyer, D Tsokos, GC Lucca, JJD AF Campbell, James C. Li, Yansong van Amersfoort, Edwin Relan, Anurag Dubick, Michael Sheppard, Forest Pusateri, Anthony Niemeyer, Debra Tsokos, George C. Lucca, Jurandir J. Dalle TI C1 INHIBITOR LIMITS ORGAN INJURY AND PROLONGS SURVIVAL IN SWINE SUBJECTED TO BATTLEFIELD SIMULATED INJURY SO SHOCK LA English DT Article DE Complement activation; cytokines; immune response; porcine; recombinant human C1 inhibitor; reperfusion injury; survival benefit; tissue damage ID DAMAGE CONTROL RESUSCITATION; PRIMARY GRAFT DYSFUNCTION; COMBAT CASUALTY CARE; TISSUE-INJURY; CONTROLLED HEMORRHAGE; LUNG TRANSPLANTATION; TRAUMA PATIENTS; PORCINE MODEL; COMPLEMENT; SHOCK AB Complement system activation is recognized as a deleterious component of the mammalian physiological response to traumatic injury with severe hemorrhage (TH). Female Yorkshire swine were subjected to a simulated austere prehospital battlefield scenario. Each animal underwent controlled hemorrhage of 22 mL/kg at 100 mL/min rate for approximately 10 min followed by soft tissue injury, femur fracture, and spleen injury. Subsequent blood loss was uncontrolled. Twenty-eight minutes postinjury the animals were randomized into treatment or no treatment with recombinant human C1 esterase inhibitor (C1INH) (500 IU/kg, n = 11) and into receiving or not permissive hypotensive resuscitation (n = 14) with infusion of 45 mL/kg lactated Ringer's solution (2 xblood lost). Observation and animal maintenance continued for 6 h at which time the animals had either expired or were euthanized. Heart, lung, and small intestine tissue samples were collected. Pharmacokinetic, hemodynamic, and metabolic parameters as well as survival time, plasma complement activity and tissue deposition, cytokine levels, and tissue injury were determined. We found that administration of C1INH protected tissues from damage, reduced the levels of inflammatory cytokines, and improved blood chemistry. Immunohistochemical analyses revealed that C1INH administration following TH markedly reduced complement activation and deposition in tissues. Importantly, C1INH administration prolonged survival of animals particularly in those which received resuscitation fluid infusion. Our data urge early administration of C1INH to limit organ damage and prolong survival of those injured in the battlefield. C1 [Campbell, James C.; Niemeyer, Debra] Wilford Hall Ambulatory Surg Ctr, Chief Scientist Off, 59MDW-ST, Joint Base San Antonio L, TX USA. [Li, Yansong; Dubick, Michael] US Army Inst Surg Res, Damage Control Resuscitat, Joint Base San Antonio F, TX USA. [van Amersfoort, Edwin; Relan, Anurag] Pharming Technol BV, Leiden, Netherlands. [Sheppard, Forest] Navel Med Res Unit, Joint Base San Antonio F, TX USA. [Pusateri, Anthony] US Army Med Res & Mat Command, Combat Casualty Care Res Program, Ft Detrick, MD USA. [Tsokos, George C.] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA USA. [Lucca, Jurandir J. Dalle] Def Threat Reduct Agcy, Chem & Biol Technol Dept, Ft Belvoir, VA USA. RP Lucca, JJD (reprint author), Def Threat Reduct Agcy, Chem & Biol Technol Dept, Translat Med Div, 8475 John J Kingman Rd, Ft Belvoir, VA 22060 USA. EM Jurandir.J.DalleLucca.mil@mail.mil NR 32 TC 1 Z9 1 U1 2 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD SEP PY 2016 VL 46 IS 3 SU 1 BP 177 EP 188 DI 10.1097/SHK.0000000000000677 PG 12 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DX3HG UT WOS:000384263600025 PM 27405065 ER PT J AU Taylor, AL Corley, JB Cap, AP Miles, EA Fisher, AD Rudesheim, SM Rachel, BM Cosgrove, TD Kellar, GG AF Taylor, A. L. Corley, J. B. Cap, A. P. Miles, E. A. Fisher, A. D. Rudesheim, S. M. Rachel, B. M. Cosgrove, T. D. Kellar, G. G. TI Advances in the Use of Whole Blood in Combat Trauma Resuscitation SO TRANSFUSION LA English DT Meeting Abstract CT AABB Annual Meeting CY OCT 22-25, 2016 CL Orlando, FL SP AABB C1 [Taylor, A. L.; Corley, J. B.] OTSG MEDCOM, Ft Sam Houston, TX USA. [Cap, A. P.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Miles, E. A.; Fisher, A. D.] 75th Ranger Regiment, Ft Benning, GA USA. [Rudesheim, S. M.] Sullivan Mem Blood Ctr, Ft Benning, GA USA. [Rachel, B. M.; Cosgrove, T. D.; Kellar, G. G.] Armed Serv Blood Bank PNW, Tacoma, WA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD SEP PY 2016 VL 56 SU 4 SI SI MA S27-020B BP 15A EP 16A PG 2 WC Hematology SC Hematology GA DX8NS UT WOS:000384646400034 ER PT J AU Corley, JB Messenger, JM Cheser, JL Griffin, EP Taylor, AL Shackelford, SA Cap, AP AF Corley, J. B. Messenger, J. M. Cheser, J. L. Griffin, E. P. Taylor, A. L. Shackelford, S. A. Cap, A. P. TI Implementation of Cold Stored Platelets for Combat Trauma Resuscitation SO TRANSFUSION LA English DT Meeting Abstract CT AABB Annual Meeting CY OCT 22-25, 2016 CL Orlando, FL SP AABB C1 [Cap, A. P.] US Army Inst Surg Res, Coagulat & Blood Res, Jbsa Ft Sam Houston, TX USA. [Cap, A. P.] Uniformed Serv Univ Hlth Sci, Med, Bethesda, MD USA. [Corley, J. B.; Taylor, A. L.] US Army Blood Program, Jbsa Ft Sam Houston, TX USA. [Messenger, J. M.] Armed Serv Blood Bank Ctr Pacific Northwest, Tacoma, WA USA. [Cheser, J. L.; Griffin, E. P.] Cent Command, Joint Theater Blood Program, MacDill Afb, FL USA. [Shackelford, S. A.] Joint Trauma Syst, Jbsa Ft Sam Houston, TX USA. [Cheser, J. L.] 932nd Med Detachment Blood Support, Bagram Ab, Afghanistan. NR 0 TC 0 Z9 0 U1 1 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD SEP PY 2016 VL 56 SU 4 SI SI MA S30-020B BP 16A EP 17A PG 2 WC Hematology SC Hematology GA DX8NS UT WOS:000384646400037 ER PT J AU Strandenes, G Kristoffersen, EK Bjerkvig, CK Fosse, TK Hervig, T Haaverstad, R Kvalheim, VL Cap, AP Lunde, TF Braathen, H Sivertsen, J Apelseth, T AF Strandenes, G. Kristoffersen, E. K. Bjerkvig, C. K. Fosse, T. K. Hervig, T. Haaverstad, R. Kvalheim, V. L. Cap, A. P. Lunde, T. F. Braathen, H. Sivertsen, J. Apelseth, T. TI Cold-stored Apheresis Platelets in Treatment of Postoperative Bleeding in Cardiothoracic Surgery SO TRANSFUSION LA English DT Meeting Abstract CT AABB Annual Meeting CY OCT 22-25, 2016 CL Orlando, FL SP AABB C1 [Strandenes, G.] Norwegian Naval Special Operat Command, Bergen, Norway. [Kristoffersen, E. K.; Hervig, T.; Lunde, T. F.; Braathen, H.; Sivertsen, J.; Apelseth, T.] Haukeland Hosp, Dept Immunol & Transfus Med, Bergen, Norway. [Kristoffersen, E. K.; Hervig, T.; Haaverstad, R.; Kvalheim, V. L.] Univ Bergen, Inst Clin Sci, Sch Med & Dent, Bergen, Norway. [Bjerkvig, C. K.; Fosse, T. K.] Haukeland Hosp, Dept Anaesthesia & Intens Care, Bergen, Norway. [Haaverstad, R.; Kvalheim, V. L.] Haukeland Hosp, Dept Hearth Dis, Sect Cardiothorac Surg, Bergen, Norway. [Cap, A. P.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Apelseth, T.] Haukeland Hosp, Lab Clin Biochem, Bergen, Norway. NR 0 TC 0 Z9 0 U1 1 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD SEP PY 2016 VL 56 SU 4 SI SI MA S29-020B BP 16A EP 16A PG 1 WC Hematology SC Hematology GA DX8NS UT WOS:000384646400036 ER PT J AU Reddoch, K Getz, T Montgomery, RK Pidcoke, HF Cap, AP AF Reddoch, K. Getz, T. Montgomery, R. K. Pidcoke, H. F. Cap, A. P. TI Strategies for Improving Stored Platelet Products SO TRANSFUSION LA English DT Meeting Abstract CT AABB Annual Meeting CY OCT 22-25, 2016 CL Orlando, FL SP AABB C1 [Reddoch, K.; Montgomery, R. K.; Cap, A. P.] US Army Inst Surg Res, San Antonio, TX USA. [Getz, T.] Cellphire, Rockville, MD USA. [Pidcoke, H. F.] Terumo BCT, Denver, CO USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD SEP PY 2016 VL 56 SU 4 SI SI MA SP67 BP 67A EP 67A PG 1 WC Hematology SC Hematology GA DX8NS UT WOS:000384646400170 ER PT J AU Meledeo, MA Liu, QP Peltier, G Carney, R Rodriguez, A Cap, AP AF Meledeo, M. A. Liu, Q. P. Peltier, G. Carney, R. Rodriguez, A. Cap, A. P. TI Hemostatic Functional Analysis of a Spray-dried Plasma SO TRANSFUSION LA English DT Meeting Abstract CT AABB Annual Meeting CY OCT 22-25, 2016 CL Orlando, FL SP AABB C1 [Meledeo, M. A.; Peltier, G.; Rodriguez, A.; Cap, A. P.] US Army Inst Surg Res, Coagulat & Blood Res, Jbsa Ft Sam Houston, TX USA. [Liu, Q. P.; Carney, R.] Velico Med Inc, Beverly, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD SEP PY 2016 VL 56 SU 4 SI SI MA SP84 BP 73A EP 74A PG 2 WC Hematology SC Hematology GA DX8NS UT WOS:000384646400187 ER PT J AU Meledeo, MA Peltier, G Fisher, AD Miles, EA Cap, AP AF Meledeo, M. A. Peltier, G. Fisher, A. D. Miles, E. A. Cap, A. P. TI Blood Bag Constriction for Volumetric Control in Austere Environments SO TRANSFUSION LA English DT Meeting Abstract CT AABB Annual Meeting CY OCT 22-25, 2016 CL Orlando, FL SP AABB C1 [Meledeo, M. A.; Peltier, G.; Cap, A. P.] US Army Inst Surg Res, Coagulat & Blood Res, Jbsa Ft Sam Houston, TX USA. [Fisher, A. D.; Miles, E. A.] 75th Ranger Regiment, Ft Benning, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD SEP PY 2016 VL 56 SU 4 SI SI MA SP96 BP 77A EP 78A PG 2 WC Hematology SC Hematology GA DX8NS UT WOS:000384646400199 ER PT J AU Bynum, JA Peltier, G Taylor, AS Meledeo, MA Cap, AP AF Bynum, J. A. Peltier, G. Taylor, A. S. Meledeo, M. A. Cap, A. P. TI Gene Expression Profiling Reveals Key Mitochondrial Gene Changes in Stored Platelets SO TRANSFUSION LA English DT Meeting Abstract CT AABB Annual Meeting CY OCT 22-25, 2016 CL Orlando, FL SP AABB C1 [Bynum, J. A.; Peltier, G.; Taylor, A. S.; Meledeo, M. A.; Cap, A. P.] US Army, Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD SEP PY 2016 VL 56 SU 4 SI SI MA SP203 BP 116A EP 117A PG 2 WC Hematology SC Hematology GA DX8NS UT WOS:000384646400307 ER PT J AU Bynum, JA Wu, X Darlington, DN Cap, AP AF Bynum, J. A. Wu, X. Darlington, D. N. Cap, A. P. TI Evaluation of Platelet Mitochondrial Function after Polytrauma and Hemorrhage in Rats SO TRANSFUSION LA English DT Meeting Abstract CT AABB Annual Meeting CY OCT 22-25, 2016 CL Orlando, FL SP AABB C1 [Bynum, J. A.; Wu, X.; Darlington, D. N.; Cap, A. P.] US Army, Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD SEP PY 2016 VL 56 SU 4 SI SI MA SP209 BP 118A EP 119A PG 2 WC Hematology SC Hematology GA DX8NS UT WOS:000384646400313 ER PT J AU Parida, BK Montgomery, RK Wendorff, DS Prat, NJ Batchinsky, AI Cap, AP AF Parida, B. K. Montgomery, R. K. Wendorff, D. S. Prat, N. J. Batchinsky, A. I. Cap, A. P. TI Propofol Interferes with Microparticle Enumeration in Blood Samples SO TRANSFUSION LA English DT Meeting Abstract CT AABB Annual Meeting CY OCT 22-25, 2016 CL Orlando, FL SP AABB C1 [Parida, B. K.; Montgomery, R. K.; Prat, N. J.; Cap, A. P.] US Army Inst Surg Res, Coagulat & Blood Res, Ft Sam Houston, TX USA. [Wendorff, D. S.; Batchinsky, A. I.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Prat, N. J.] IRBA, Paris, France. RI PRAT, Nicolas/R-4213-2016 NR 0 TC 0 Z9 0 U1 1 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD SEP PY 2016 VL 56 SU 4 SI SI MA SP216 BP 120A EP 121A PG 2 WC Hematology SC Hematology GA DX8NS UT WOS:000384646400320 ER PT J AU Harper, HL Montgomery, RK Darlington, DN Cap, AP Wu, X AF Harper, H. L., Jr. Montgomery, R. K. Darlington, D. N. Cap, A. P. Wu, X. TI Determine the Optimal Anti-Coagulant for Measurement of Platelet Counts SO TRANSFUSION LA English DT Meeting Abstract CT AABB Annual Meeting CY OCT 22-25, 2016 CL Orlando, FL SP AABB C1 [Harper, H. L., Jr.; Montgomery, R. K.; Darlington, D. N.; Cap, A. P.; Wu, X.] US Army, Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD SEP PY 2016 VL 56 SU 4 SI SI MA SP223 BP 122A EP 123A PG 2 WC Hematology SC Hematology GA DX8NS UT WOS:000384646400327 ER PT J AU Darlington, DN Chen, J Wu, X Cap, AP AF Darlington, D. N. Chen, J. Wu, X. Cap, A. P. TI Polytrauma and Hemorrhage in Rat Leads to MOF, Coagulopathy, Inflammation, and Metabolic Disorders SO TRANSFUSION LA English DT Meeting Abstract CT AABB Annual Meeting CY OCT 22-25, 2016 CL Orlando, FL SP AABB C1 [Darlington, D. N.; Wu, X.; Cap, A. P.] US Army Inst Surg Res, Blood, Jbsa Ft Sam Houston, TX USA. [Darlington, D. N.; Wu, X.; Cap, A. P.] Univ Texas Hlth Sci Ctr, Surg, San Antonio, TX USA. [Chen, J.] Israeli Def Force, Tel Aviv, Israel. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD SEP PY 2016 VL 56 SU 4 SI SI MA SP377 BP 175A EP 175A PG 1 WC Hematology SC Hematology GA DX8NS UT WOS:000384646400481 ER PT J AU Taylor, AL Melanie, SA Ellerbe, L Lumzy, F Burke, J Oliveri, J Corley, JB AF Taylor, A. L. Melanie, S. A. Ellerbe, L. Lumzy, F. Burke, J. Oliveri, J. Corley, J. B. TI Building a Major Military Blood Drive SO TRANSFUSION LA English DT Meeting Abstract CT AABB Annual Meeting CY OCT 22-25, 2016 CL Orlando, FL SP AABB C1 [Taylor, A. L.; Corley, J. B.] OTSG MEDCOM, San Antonio, TX USA. [Melanie, S. A.] Kendrick Mem Blood Ctr, Augusta, GA USA. [Ellerbe, L.] Ft Bragg Blood Donor Ctr, Ft Bragg, NC USA. [Lumzy, F.] Sullivan Mem Blood Ctr, Ft Benning, GA USA. [Burke, J.] Ft Leonard Wood Blood Donor Ctr, Ft Leonard Wood, MO USA. [Oliveri, J.] Armed Serv Blood Program, Falls Church, VA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD SEP PY 2016 VL 56 SU 4 SI SI MA AP26 BP 229A EP 229A PG 1 WC Hematology SC Hematology GA DX8NS UT WOS:000384646400627 ER PT J AU Saproo, S Faller, J Shih, V Sajda, P Waytowich, NR Bohannon, A Lawhern, VJ Lance, BJ Jangraw, D AF Saproo, Sameer Faller, Josef Shih, Victor Sajda, Paul Waytowich, Nicholas R. Bohannon, Addison Lawhern, Vernon J. Lance, Brent J. Jangraw, David TI Cortically Coupled Computing: A New Paradigm for Synergistic Human-Machine Interaction SO COMPUTER LA English DT Article ID VISION AB Unlike traditional brain-computer interfaces that use brain signals for direct control of computers and robotics, a cortically coupled computer system opportunistically senses the brain state, capturing a user's implicit or explicit computation, and then communicates this information to a traditional computer system via a neural interface. C1 [Saproo, Sameer; Shih, Victor; Sajda, Paul] Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA. [Faller, Josef; Sajda, Paul] Columbia Univ, Lab Intelligent Imaging & Neural Comp, New York, NY 10027 USA. [Sajda, Paul] Columbia Univ, Dept Elect Engn, New York, NY 10027 USA. [Sajda, Paul] Columbia Univ, Dept Radiol, New York, NY 10027 USA. [Waytowich, Nicholas R.; Lawhern, Vernon J.; Lance, Brent J.] US Army Res Lab, Human Res & Engn Directorate, Adelphi, MD USA. [Bohannon, Addison] US Army Res Lab, Adelphi, MD USA. [Jangraw, David] NIMH, Sect Funct Imaging Methods, Bethesda, MD 20892 USA. RP Saproo, S (reprint author), Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA. EM ssaproo.ucsd@gmail.com; josef.faller@columbia.edu; vs2481@columbia.edu; psajda@columbia.edu; nick.waytowich@gmail.com; addisonb@math.umd.edu; vernon.j.lawhern.civ@mail.mil; brent.j.lance.civ@mail.mil; david.jangraw@nih.gov FU Defense Advanced Research Projects Agency (DARPA); Army Research Office (ARO) [W911NF-11-1-0219]; Army Research Laboratory (ARL) [W911NF-10-2-0022]; Office of the Secretary of Defense Autonomy Research Pilot Initiative program [MIPR DWAM31168]; UK Economic and Social Research Council [ES/L012995/1] FX This work was funded by the Defense Advanced Research Projects Agency (DARPA), the Army Research Office (ARO) under grant number W911NF-11-1-0219, the Army Research Laboratory (ARL) under cooperative agreement number W911NF-10-2-0022, the Office of the Secretary of Defense Autonomy Research Pilot Initiative program MIPR DWAM31168, and the UK Economic and Social Research Council under grant number ES/L012995/1. NR 13 TC 0 Z9 0 U1 2 U2 2 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 0018-9162 EI 1558-0814 J9 COMPUTER JI Computer PD SEP PY 2016 VL 49 IS 9 BP 60 EP 68 PG 9 WC Computer Science, Hardware & Architecture; Computer Science, Software Engineering SC Computer Science GA DX1MX UT WOS:000384132600009 ER PT J AU Yee, MK Seichepine, DR Janulewicz, PA Sullivan, KA Proctor, SP Krengel, MH AF Yee, Megan K. Seichepine, Daniel R. Janulewicz, Patricia A. Sullivan, Kimberly A. Proctor, Susan P. Krengel, Maxine H. TI Self-Reported Traumatic Brain Injury, Health and Rate of Chronic Multisymptom Illness in Veterans From the 1990-1991 Gulf War SO JOURNAL OF HEAD TRAUMA REHABILITATION LA English DT Article DE chronic multisymptom illness; Gulf War; traumatic brain injury ID QUALITY-OF-LIFE; POSTTRAUMATIC-STRESS-DISORDER; NEURON-SPECIFIC ENOLASE; US ARMY VETERANS; PSYCHIATRIC-DISORDERS; FOLLOW-UP; SERUM CONCENTRATIONS; BIOCHEMICAL MARKERS; CARE UTILIZATION; DAMAGE S-100B AB Background: Traumatic brain injury (TBI) was not considered to be common in the 1990-1991 Gulf War (GW). Therefore, the relationship between TBI and chronic health symptoms experienced by GW veterans is unknown. Health symptoms reported by veterans deployed more recently to this region (Operations Enduring and Iraqi Freedom) are similar to those of GW veterans and have been primarily attributed to TBI. Objective: To examine the relationships among self-reported TBI, health symptoms, chronic multisymptom illness (CMI), and health-related quality of life among GW veterans. Participants: Participants included 1 274 GW veterans from the Devens Cohort Study, 156 of whom self-reported a history of TBI (12.2% of the sample). Design: Cross-sectional retrospective analysis of existing survey data. Main Measures: A 52-item health symptom checklist and the RAND 36-Item Health short Form Survey. Results: Self-reported TBI in GW Veterans is related to increased rates of health symptoms, CMI, and poorer health-related quality of life. Conclusions: Gulf War veterans' self-reported exposure to TBI is related to increased rates of chronic health symptoms and CMI, which interfere with everyday activities of daily living. C1 [Yee, Megan K.; Proctor, Susan P.] VA Boston Healthcare Syst, Res Serv, 150 S Huntington Ave,D12-87, Boston, MA 02130 USA. [Krengel, Maxine H.] VA Boston Healthcare Syst, Psychol Res, Boston, MA 02130 USA. [Yee, Megan K.] Boston Univ, Sch Publ Hlth, Boston, MA USA. [Seichepine, Daniel R.] Univ New Hampshire, Div Social Sci, Manchester, NH USA. [Janulewicz, Patricia A.; Sullivan, Kimberly A.; Proctor, Susan P.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA. [Proctor, Susan P.] US Army, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Krengel, Maxine H.] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA. RP Yee, MK (reprint author), VA Boston Healthcare Syst, Res Serv, 150 S Huntington Ave,D12-87, Boston, MA 02130 USA. EM meganyee@bu.edu OI Sullivan, Kimberly/0000-0001-7940-6123 NR 67 TC 2 Z9 2 U1 3 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0885-9701 EI 1550-509X J9 J HEAD TRAUMA REHAB JI J. Head Trauma Rehabil. PD SEP-OCT PY 2016 VL 31 IS 5 BP 320 EP 328 DI 10.1097/HTR.0000000000000173 PG 9 WC Clinical Neurology; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA DX2ZY UT WOS:000384243600010 PM 26291628 ER PT J AU Alosco, ML Aslan, M Du, MT Ko, J Grande, L Proctor, SP Concato, J Vasterling, JJ AF Alosco, Michael L. Aslan, Mihaela Du, Mengtian Ko, John Grande, Laura Proctor, Susan P. Concato, John Vasterling, Jennifer J. TI Consistency of Recall for Deployment-Related Traumatic Brain Injury SO JOURNAL OF HEAD TRAUMA REHABILITATION LA English DT Article DE OIF; PTSD; recall consistency; TBI screening; traumatic brain injury ID POSTTRAUMATIC-STRESS-DISORDER; NATIONAL-GUARD; MEMORY; VETERANS; IRAQ; STABILITY; VALIDITY; EVENTS; EXPOSURE; OUTCOMES AB Objective: To examine the temporal consistency of self-reported deployment-related traumatic brain injury (TBI) and its association with posttraumatic stress disorder (PTSD) symptom severity. Setting: In-person interviews at US Army installations (postdeployment); phone interviews (long-term follow-up). Participants: A total of 378 US Army soldiers and veterans deployed to Iraq; 14.3% (n = 54) reported TBI with loss of consciousness during an index deployment. Design: Participants were evaluated after returning from deployment and again 5 to 9 years later. Main Measures: Temporal consistency of TBI endorsement based on TBI screening interviews; PTSD Checklist, Civilian Version. Results: The concordance of deployment-related TBI endorsement from the postdeployment to long-term follow-up assessment was moderate (kappa = 0.53). Of the 54 participants reporting (predominantly mild) TBI occurring during an index deployment, 32 endorsed TBI inconsistently over time. More severe PTSD symptoms at postdeployment assessment were independently associated with discordant reporting (P =.0004); each 10-point increase in PCL scores increasing odds of discordance by 69% (odds ratio = 1.69; 95% confidence interval, 1.26-2.26). Conclusions: Deployment-related TBI may not be reported reliably over time, particularly among war-zone veterans with greater PTSD symptoms. Results of screening evaluations for TBI history should be viewed with caution in the context of PTSD symptom history. C1 [Alosco, Michael L.; Grande, Laura; Vasterling, Jennifer J.] VA Boston Healthcare Syst, Psychol Serv, 150 S Huntington Ave, Boston, MA 02130 USA. [Aslan, Mihaela; Ko, John; Concato, John] VA Connecticut Healthcare Syst, Clin Epidemiol Res Ctr, West Haven, CT USA. [Aslan, Mihaela; Ko, John; Concato, John] Yale Univ, Sch Med, Dept Med, New Haven, CT 06510 USA. [Du, Mengtian] Yale Grad Sch Arts & Sci, Dept Publ Hlth, New Haven, CT USA. [Grande, Laura; Vasterling, Jennifer J.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA. [Proctor, Susan P.] US Army Res Inst Environm Med, Natick, MA USA. [Proctor, Susan P.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA. [Vasterling, Jennifer J.] VA Boston Healthcare Syst, Natl Ctr PTSD, 150 S Huntington Ave, Boston, MA 02130 USA. [Alosco, Michael L.] Boston Univ, Sch Med, Alzheimers Dis & CTE Ctr, Boston, MA 02118 USA. RP Vasterling, JJ (reprint author), VA Boston Healthcare Syst, Psychol Serv 116B, 150 S Huntington Ave, Boston, MA 02130 USA. EM jennifer.vasterling@va.gov FU US Army Medical Research and Materiel Command [DAMD 17-03-0020]; Department of Veterans Affairs (VA) Clinical Sciences Research and Development; VA Cooperative Studies Program (VA CSP) [566] FX Funding for the collection of postdeployment data was provided by the US Army Medical Research and Materiel Command (DAMD 17-03-0020) and the Department of Veterans Affairs (VA) Clinical Sciences Research and Development. Funding for all other aspects of the work was provided by VA Cooperative Studies Program (VA CSP# 566). The authors are grateful to the soldiers and military veterans who comprise the Neurocognition Deployment Health Study cohort for their long-standing participation in the research and for their military service more generally. NR 33 TC 2 Z9 2 U1 5 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0885-9701 EI 1550-509X J9 J HEAD TRAUMA REHAB JI J. Head Trauma Rehabil. PD SEP-OCT PY 2016 VL 31 IS 5 BP 360 EP 368 DI 10.1097/HTR.0000000000000201 PG 9 WC Clinical Neurology; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA DX2ZY UT WOS:000384243600014 PM 26580696 ER PT J AU DuBose, JJ Scalea, TM Brenner, M Skiada, D Inaba, K Cannon, J Moore, L Holcomb, J Turay, D Arbabi, CN Kirkpatrick, A Xiao, J Skarupa, D Poulin, N AF DuBose, Joseph J. Scalea, Thomas M. Brenner, Megan Skiada, Dimitra Inaba, Kenji Cannon, Jeremy Moore, Laura Holcomb, John Turay, David Arbabi, Cassra N. Kirkpatrick, Andrew Xiao, James Skarupa, David Poulin, Nathaniel CA AAST AORTA Study Grp TI The AAST prospective Aortic Occlusion for Resuscitation in Trauma and Acute Care Surgery (AORTA) registry: Data on contemporary utilization and outcomes of aortic occlusion and resuscitative balloon occlusion of the aorta (REBOA) SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article; Proceedings Paper CT 74th Annual Meeting of the American-Association-for-the-Surgery-of-Trauma CY SEP 09-12, 2015 CL Las Vegas, NV SP Amer Assoc Surg Trauma DE Aortic occlusion; trauma; REBOA; mortality; resuscitation ID EMERGENCY-DEPARTMENT THORACOTOMY; COURSE CURRICULUM-DEVELOPMENT; ENDOVASCULAR SKILLS; CONTENT VALIDATION; PROGRAM ASSESSMENT; HEMORRHAGIC-SHOCK; APPROPRIATE USE; REPAIR AB INTRODUCTION Aortic occlusion (AO) for resuscitation in traumatic shock remains controversial. Resuscitative endovascular balloon occlusion of the aorta (REBOA) offers an emerging alternative. METHODS The American Association for the Surgery of Trauma Aortic Occlusion for Resuscitation in Trauma and Acute Care Surgery registry prospectively identified trauma patients requiring AO from eight ACS Level 1 centers. Presentation, intervention, and outcome variables were collected and analyzed to compare REBOA and open AO. RESULTS From November 2013 to February 2015, 114 AO patients were captured (REBOA, 46; open AO, 68); 80.7% were male, and 62.3% were blunt injured. Aortic occlusion occurred in the emergency department (73.7%) or the operating room (26.3%). Hemodynamic improvement after AO was observed in 62.3% [REBOA, 67.4%; open OA, 61.8%); 36.0% achieving stability (systolic blood pressure consistently >90 mm Hg, >5 minutes); REBOA, 22 of 46 (47.8%); open OA, 19 of 68 (27.9%); p =0.014]. Resuscitative endovascular balloon occlusion of the aorta (REBOA) access was femoral cut-down (50%); US guided (10.9%) and percutaneous without imaging (28.3%). Deployment was achieved in Zones I (78.6%), II (2.4%), and III (19.0%). A second AO attempt was required in 9.6% [REBOA, 2 of 46 (4.3%); open OA, 9 of 68 (13.2%)]. Complications of REBOA were uncommon (pseudoaneurysm, 2.1%; embolism, 4.3%; limb ischemia, 0%). There was no difference in time to successful AO between REBOA and open procedures (REBOA, 6.6 5.6 minutes; open OA, 7.2 15.1; p = 0.842). Overall survival was 21.1% (24 of 114), with no significant difference between REBOA and open AO with regard to mortality [REBOA, 28.2% (13 of 46); open OA, 16.1% (11 of 68); p = 0.120]. CONCLUSION Resuscitative endovascular balloon occlusion of the aorta has emerged as a viable alternative to open AO in centers that have developed this capability. Further maturation of the American Association for the Surgery of Trauma Aortic Occlusion for Resuscitation in Trauma and Acute Care Surgery database is required to better elucidate optimal indications and outcomes. LEVEL OF EVIDENCE Therapeutic/care management study, level IV. C1 [DuBose, Joseph J.] Univ Calif Davis, David Grant Med Ctr, Davis, CA 95616 USA. [Scalea, Thomas M.; Brenner, Megan] Univ Maryland, Med Ctr, R Adams Cowley Shock Trauma Ctr, Dept Surg, Baltimore, MD 21201 USA. [Skiada, Dimitra; Inaba, Kenji] Los Angeles Cty Univ Southern Calif Hosp, Los Angeles, CA USA. [Cannon, Jeremy] US Army Inst Surg Res, San Antonio Mil Med Ctr, San Antonio, TX USA. [Moore, Laura; Holcomb, John] Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA. [Turay, David; Arbabi, Cassra N.] Loma Linda Univ, Med Ctr, Loma Linda, CA USA. [Kirkpatrick, Andrew; Xiao, James] Univ Calgary, Calgary, AB, Canada. [Skiada, Dimitra] Univ Florida Jacksonville, Jacksonville, FL USA. [Poulin, Nathaniel] East Carolina Med Ctr, New Bern, NC USA. RP DuBose, JJ (reprint author), 101 Boden Circle, Travis AFB, CA 94535 USA. EM jjd3c@yahoo.com NR 21 TC 2 Z9 2 U1 2 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD SEP PY 2016 VL 81 IS 3 BP 409 EP 419 DI 10.1097/TA.0000000000001079 PG 11 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA DW8MX UT WOS:000383911200001 PM 27050883 ER PT J AU Linnebur, M Inaba, K Haltmeier, T Rasmussen, TE Smith, J Mendelsberg, R Grabo, D Demetriades, D AF Linnebur, Megan Inaba, Kenji Haltmeier, Tobias Rasmussen, Todd E. Smith, Jennifer Mendelsberg, Ranan Grabo, Daniel Demetriades, Demetrios TI Emergent non-image-guided resuscitative endovascular balloon occlusion of the aorta (REBOA) catheter placement: A cadaver-based study SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Balloon occlusion; catheter; cadaver; resuscitation ID HEMORRHAGIC-SHOCK; ABDOMINAL-TRAUMA; FLUOROSCOPY-FREE; MODEL; DEATH; EPIDEMIOLOGY; ANATOMY; SYSTEM AB BACKGROUND Emergent resuscitative endovascular balloon occlusion of the aorta (REBOA) insertion for critically injured patients in hemorrhagic shock is performed blindly with fluoroscopic imaging confirmation. The aim of this study was to determine a reliable method for initial REBOA catheter insertion with balloon deployment between the left subclavian artery takeoff and the celiac trunk (CT). METHODS Human cadaver study. External surface (sternal notch, mid-sternum, xiphoid) and intravascular (left subclavian artery [LSA], and CT) landmarks were measured from standardized left and right common femoral artery puncture sites. The landing zone (LZ, distance between LSA and CT) and margins of safety (distance from distal balloon edge to LSA and proximal balloon edge to CT) were calculated using intravascular landmarks. The probability of balloon deployment in the LZ using external landmarks was compared in univariate analysis using the Fisher exact test. RESULTS Ten cadavers were analyzed (seven males; mean body mass index, 19.4 kg/m(2)). Mean (SD) intravascular distances from femoral puncture sites to the LSA and CT were 54.8 (1.9) cm and 32.9 (1.9) cm. The mean (SD) LZ was 21.8 (3.8) cm. Mean (SD) surface distances from femoral puncture sites to the xiphoid, mid-sternum, and sternal notch were 31.8 (3.9) cm, 41.8 (3.3) cm, and 51.8 (3.2) cm. Inserting the catheter to a distance approximated by surface distance from the femoral puncture site to mid-sternum resulted in a 100% likelihood balloon deployment in the LZ for both sides. This was superior to the xiphoid and sternal notch (left site, p = 0.005; right site, p = 0.036; mean of both sites, p = 0.083). Using the mid-sternum landmark, the mean (SD) margins of safety to the LSA and CT were 10.7 (4.3) cm and 3.1 (3.4) cm. CONCLUSION When using the use of the mid-sternum landmark for REBOA balloon placement, the likelihood of balloon deployment in the LZ was 100% with an acceptable margin of safety. C1 [Linnebur, Megan; Inaba, Kenji; Haltmeier, Tobias; Mendelsberg, Ranan; Grabo, Daniel; Demetriades, Demetrios] Los Angeles Cty & Univ Southern Calif Med Ctr, Dept Surg, Div Acute Care Surg & Surg Crit Care, Los Angeles, CA USA. [Rasmussen, Todd E.] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Smith, Jennifer] Harbor UCLA Med Ctr, Torrance, CA 90509 USA. RP Inaba, K (reprint author), Univ Southern Calif, Dept Surg, LAC USC Med Ctr, Room C5L100,Inpatient Tower C,2051 Marengo St, Los Angeles, CA 90033 USA. EM kenji.inaba@usc.edu NR 23 TC 1 Z9 1 U1 2 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD SEP PY 2016 VL 81 IS 3 BP 453 EP 457 DI 10.1097/TA.0000000000001106 PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA DW8MX UT WOS:000383911200007 PM 27192466 ER PT J AU Thurman, D Poinsatte, P Ameri, A Culley, D Raghu, S Shyam, V AF Thurman, Douglas Poinsatte, Philip Ameri, Ali Culley, Dennis Raghu, Surya Shyam, Vikram TI Investigation of Spiral and Sweeping Holes SO JOURNAL OF TURBOMACHINERY-TRANSACTIONS OF THE ASME LA English DT Article AB Surface infrared thermography, hotwire anemometry, and thermocouple surveys were performed on two new film cooling hole geometries: spiral/rifled holes and fluidic sweeping holes. The spiral holes attempt to induce large-scale vorticity to the film cooling jet as it exits the hole to prevent the formation of the kidney-shaped vortices commonly associated with film cooling jets. The fluidic sweeping hole uses a passive in-hole geometry to induce jet sweeping at frequencies that scale with blowing ratios. The spiral hole performance is compared to that of round holes with and without compound angles. The fluidic hole is of the diffusion class of holes and is therefore compared to a 777 hole and square holes. A patent-pending spiral hole design showed the highest potential of the nondiffusion-type hole configurations. Velocity contours and flow temperature were acquired at discreet cross sections of the downstream flow field. The passive fluidic sweeping hole shows the most uniform cooling distribution but suffers from low span-averaged effectiveness levels due to enhanced mixing. The data were taken at a Reynolds number of 11,000 based on hole diameter and freestream velocity. Infrared thermography was taken for blowing ratios of 1.0, 1.5, 2.0, and 2.5 at a density ratio of 1.05. The flow inside the fluidic sweeping hole was studied using 3D unsteady Reynolds-average Navier-Stokes (RANS). C1 [Thurman, Douglas] US Army Res Lab, Cleveland, OH 44135 USA. [Poinsatte, Philip; Culley, Dennis; Shyam, Vikram] NASA Glenn Res Ctr, Cleveland, OH 44135 USA. [Ameri, Ali] Ohio State Univ, Dept Mech & Aerosp Engn, Columbus, OH 43210 USA. [Raghu, Surya] Adv Fluid LLC, Columbia, MD 21045 USA. RP Thurman, D (reprint author), US Army Res Lab, Cleveland, OH 44135 USA. EM drthurman@nasa.gov; poinsatte@nasa.gov; ali.a.ameri@nasa.gov; dennis.e.culley@nasa.gov; sraghu@advancedfluidics.com; vikram.shyam-1@nasa.gov FU NASA's Fundamental Aeronautics Program's Fixed Wing Project; NASA's Center Innovation Fund FX This work was funded by NASA's Fundamental Aeronautics Program's Fixed Wing Project and NASA's Center Innovation Fund. The authors would also like to thank Dr. Mark Wernet and Dr. Adam Wroblewski for the particle image velocimetry results. NR 15 TC 0 Z9 0 U1 0 U2 0 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0889-504X EI 1528-8900 J9 J TURBOMACH JI J. Turbomach.-Trans. ASME PD SEP PY 2016 VL 139 IS 9 AR 091007 DI 10.1115/1.4032839 PG 11 WC Engineering, Mechanical SC Engineering GA DX3BE UT WOS:000384246800007 ER PT J AU Osgood, RM Giardini, S Carlson, J Periasamy, P Guthrey, H O'Hayre, R Chin, M Nichols, B Dubey, M Fernandes, G Kim, JH Xu, J Parilla, P Berry, J Ginley, D AF Osgood, Richard M., III Giardini, Stephen Carlson, Joel Periasamy, Prakash Guthrey, Harvey O'Hayre, Ryan Chin, Matthew Nichols, Barbara Dubey, Madan Fernandes, Gustavo Kim, Jin Ho Xu, Jimmy Parilla, Philip Berry, Joseph Ginley, David TI Conduction and rectification in NbOx- and NiO-based metal-insulator-metal diodes SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A LA English DT Article ID TUNNEL-JUNCTION; WAVELENGTHS; MICROWAVE; RADIATION; BARRIERS; FILM AB Conduction and rectification in nanoantenna-coupled NbOx- and NiO-based metal-insulator-metal (MIM) diodes ("nanorectennas") are studied by comparing new theoretical predictions with the measured response of nanorectenna arrays. A new quantum mechanical model is reported and agrees with measurements of current-voltage (I-V) curves, over 10 orders of magnitude in current density, from [NbOx(native)-Nb2O5]- and NiO-based samples with oxide thicknesses in the range of 5-36 nm. The model, which introduces new physics and features, including temperature, electron effective mass, and image potential effects using the pseudobarrier technique, improves upon widely used earlier models, calculates the MIM diode's I-V curve, and predicts quantitatively the rectification responsivity of high frequency voltages generated in a coupled nanoantenna array by visible/near-infrared light. The model applies both at the higher frequencies, when high-energy photons are incident, and at lower frequencies, when the formula for classical rectification, involving derivatives of the I-V curve, may be used. The rectified low-frequency direct current is well-predicted in this work's model, but not by fitting the experimentally measured I-V curve with a polynomial or by using the older Simmons model (as shown herein). By fitting the measured I-V curves with our model, the barrier heights in Nb-(NbOx(native)-Nb2O5)-Pt and Ni-NiO-Ti/Ag diodes are found to be 0.41/0.77 and 0.38/0.39 eV, respectively, similar to literature reports, but with effective mass much lower than the free space value. The NbOx (native)-Nb2O5 dielectric properties improve, and the effective Pt-Nb2O5 barrier height increases as the oxide thickness increases. An observation of direct current of similar to 4 nA for normally incident, focused 514 nm continuous wave laser beams are reported, similar in magnitude to recent reports. This measured direct current is compared to the prediction for rectified direct current, given by the rectification responsivity, calculated from the I-V curve times input power. (C) 2016 American Vacuum Society. C1 [Osgood, Richard M., III; Giardini, Stephen; Carlson, Joel] US Army Natick Soldier Res Dev & Engn Ctr NSRDEC, 15 Gen Greene Ave, Natick, MA 01760 USA. [Periasamy, Prakash; Guthrey, Harvey; O'Hayre, Ryan] Colorado Sch Mines, Dept Met & Mat Engn, Golden, CO 80401 USA. [Chin, Matthew; Nichols, Barbara; Dubey, Madan] US Army Res Lab, RF & Elect Div, Adelphi, MD 20783 USA. [Fernandes, Gustavo; Kim, Jin Ho; Xu, Jimmy] Brown Univ, Div Engn, Box D, Providence, RI 02912 USA. [Parilla, Philip; Berry, Joseph; Ginley, David] Natl Renewable Energy Lab, Golden, CO 80401 USA. [Periasamy, Prakash] GlobalFoundries, Essex Jct, VT 05451 USA. RP Osgood, RM (reprint author), US Army Natick Soldier Res Dev & Engn Ctr NSRDEC, 15 Gen Greene Ave, Natick, MA 01760 USA. EM richard.m.osgood.civ@mail.mil NR 25 TC 0 Z9 0 U1 6 U2 6 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0734-2101 EI 1520-8559 J9 J VAC SCI TECHNOL A JI J. Vac. Sci. Technol. A PD SEP PY 2016 VL 34 IS 5 AR 051514 DI 10.1116/1.4960962 PG 13 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA DX3HH UT WOS:000384263700030 ER PT J AU Stapanian, MA Rodriguez, K Lewis, TE Blume, L Palmer, CJ Walters, L Schofield, J Amos, MM Bucher, A AF Stapanian, Martin A. Rodriguez, Karen Lewis, Timothy E. Blume, Louis Palmer, Craig J. Walters, Lynn Schofield, Judith Amos, Molly M. Bucher, Adam TI Announcementguidance document for acquiring reliable data in ecological restoration projects SO RESTORATION ECOLOGY LA English DT Article DE Great Lakes Restoration Initiative; guidance document; QA; QC AB The Laurentian Great Lakes are undergoing intensive ecological restoration in Canada and the United States. In the United States, an interagency committee was formed to facilitate implementation of quality practices for federally funded restoration projects in the Great Lakes basin. The Committee's responsibilities include developing a guidance document that will provide a common approach to the application of quality assurance and quality control (QA/QC) practices for restoration projects. The document will serve as a how-to guide for ensuring data quality during each aspect of ecological restoration projects. In addition, the document will provide suggestions on linking QA/QC data with the routine project data and hints on creating detailed supporting documentation. Finally, the document will advocate integrating all components of the project, including QA/QC applications, into an overarching decision-support framework. The guidance document is expected to be released by the U.S. EPA Great Lakes National Program Office in 2017. C1 [Stapanian, Martin A.] US Geol Survey, 6100 Columbus Ave, Sandusky, OH 44870 USA. [Rodriguez, Karen; Blume, Louis] US EPA, Great Lakes Natl Program Off, 77 West Jackson,G-17J, Chicago, IL 60604 USA. [Lewis, Timothy E.] US Army Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. [Palmer, Craig J.; Walters, Lynn; Schofield, Judith; Amos, Molly M.; Bucher, Adam] CSC Govt Solut LLC, 6361 Walker Lane, Alexandria, VA 22310 USA. RP Rodriguez, K (reprint author), US EPA, Great Lakes Natl Program Off, 77 West Jackson,G-17J, Chicago, IL 60604 USA. EM rodriguez.karen@epa.gov FU U.S. Environmental Protection Agency [EP-C-12-008] FX Use of trade, product, or firm names does not imply endorsement by the U.S. EPA, U.S. Geological Survey, U.S. Army, or any other agency of the United States government. This article is Contribution 2028 of the U.S. Geological Survey Great Lakes Science Center. Some of the information in this document has been funded by the U.S. Environmental Protection Agency under contract number EP-C-12-008 to CSC. Although some of the research described in this article has been funded by the U.S. Environmental Protection Agency, it has not been subjected to Agency review. Any opinions expressed in this publication are those of the author(s) and do not, necessarily, reflect the official positions and policies of the U.S. EPA. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. NR 10 TC 0 Z9 0 U1 11 U2 11 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1061-2971 EI 1526-100X J9 RESTOR ECOL JI Restor. Ecol. PD SEP PY 2016 VL 24 IS 5 BP 570 EP 572 DI 10.1111/rec.12367 PG 3 WC Ecology SC Environmental Sciences & Ecology GA DW9UW UT WOS:000384009200001 ER PT J AU Peterson, MS Slack, WT Lang, ET AF Peterson, Mark S. Slack, William T. Lang, Erik T. TI Distribution, Abundance, and Habitat Characteristics of Fundulus jenkinsi (Evermann) (Saltmarsh Topminnow) in Coastal Mississippi Watersheds, with Comments on Range-wide Occurrences Based on Non-vouchered and Museum Records SO SOUTHEASTERN NATURALIST LA English DT Article ID ECOLOGICAL MODEL; LIFE-HISTORY; LUCIAE BAIRD; FISH; NEKTON; REPRODUCTION; CRUSTACEANS; ESTUARY; USA AB Fundulus jenkinsi (Saltmarsh Topminnow) is listed as "at risk" by the USFWS and as a Tier 2 conservation priority in Mississippi, in part, because of marsh-habitat loss due to storms, urbanization, and its specialized habitat requirements and limited geographic distribution. To provide additional quantitative data for conservation planning, our objectives were to (1) determine the distribution and abundance of Saltmarsh Topminnow within coastal Mississippi, (2) characterize its habitat requirements, and (3) organize and present all Saltmarsh Topminnow data records (non-vouchered and museum records and those from this study) for use in the development of management/conservation plans. We collected 497 fish and associated habitat data from 27 February to 1 August 2009. PCA produced 3 meaningful components: (1) a landscape-position axis (32.40% of the total variance), (2) a seasonal/spatial axis of species occurrence (18.99%), and (3) a geomorphic bank-slope axis (18.78%). Ninety-six percent of all fish (representing 78.8% of collection effort) were captured in water with salinity <13 psu. We compiled 831 geo-referenced occurrences with collection dates ranging from 1891 to 2015. To better quantify and conserve the closely-linked habitat requirements of this species within a reduced salinity range, additional sampling should be focused in undersampled areas between Lake Borgne, LA, to west of Galveston Bay, TX. C1 [Peterson, Mark S.] Univ Southern Mississippi, Dept Coastal Sci, 703 East Beach Dr, Ocean Springs, MS 39564 USA. [Slack, William T.] Mississippi Museum Nat Sci, Mississippi Dept Wildlife Fisheries & Pk, 2148 Riverside Dr, Jackson, MS 39202 USA. [Slack, William T.] US Army Engineer Res & Dev Ctr, Waterways Expt Stn EE A, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. [Lang, Erik T.] Louisiana Dept Wildlife & Fisheries, Fisheries Management, 2000 Quail Dr, Baton Rouge, LA 70817 USA. RP Peterson, MS (reprint author), Univ Southern Mississippi, Dept Coastal Sci, 703 East Beach Dr, Ocean Springs, MS 39564 USA. EM ecofishconsulting@gmail.com FU US Fish and Wildlife Service through State Wildlife Grant [T-7-1] FX We thank J. D. Lopez, P. Grammer, M. Lowe, J.-M. Havrylkoff, M. Andres, and S. Manning for all their help on this project. Sara LeCroy provided records from the GCRL Museum, and S. T. Ross provided access to the compiled database from the Inland Fishes of Mississippi. George Guillen and John Knight provided non-vouchered collection records from their regions. This Project was funded by the US Fish and Wildlife Service through State Wildlife Grant T-7-1 funds administered through the Mississippi Department of Wildlife, Fisheries, and Parks. This research was approved and performed under the University of Southern Mississippi IACUC protocol # 10040802. NR 56 TC 0 Z9 0 U1 4 U2 4 PU HUMBOLDT FIELD RESEARCH INST PI STEUBEN PA PO BOX 9, STEUBEN, ME 04680-0009 USA SN 1528-7092 EI 1938-5412 J9 SOUTHEAST NAT JI Southeast. Nat. PD SEP PY 2016 VL 15 IS 3 BP 415 EP 430 PG 16 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA DX5UP UT WOS:000384448300008 ER PT J AU McIntyre, MK Clifford, JL Maani, CV Burmeister, DM AF McIntyre, Matthew K. Clifford, John L. Maani, Christopher V. Burmeister, David M. TI Progress of clinical practice on the management of burn-associated pain: Lessons from animal models SO BURNS LA English DT Review DE Burn pain; Animal models; Hyperalgesia; Allodynia; Analgesia ID SPINAL NERVE LIGATION; ACUTE INFLAMMATORY PAIN; RANDOMIZED DOUBLE-BLIND; ACUTE LUNG INJURY; NEUROPATHIC PAIN; MECHANICAL ALLODYNIA; THERMAL-INJURY; PORCINE MODEL; RAT MODEL; PERIPHERAL INFLAMMATION AB Opioid-based analgesics provide the mainstay for attenuating burn pain, but they have a myriad of side effects including respiratory depression, nausea, impaired gastrointestinal motility, sedation, dependence, physiologic tolerance, and opioid-induced hyperalgesia. To test and develop novel analgesics, validated burn-relevant animal models of pain are indispensable. Herein we review such animal models, which are mostly limited to rodent models of burn-induced, inflammatory, and neuropathic pain. The latter two are pain syndromes that provide insight into the pain caused by systemic pro-inflammatory cytokines and direct injury to nerves (e.g., after severe bum), respectively. To date, no single animal model optimally mimics the complex pathophysiology and pain that a human bum patient experiences. No currently available burn-pain model examines effects of pharmacological intervention on wound healing. As cornerstones of pain and wound healing, pro inflammatory mediators maybe utilized for insight into both processes. Moreover, common clinical concerns such as systemic inflammatory response syndrome and multiple organ dysfunction remain unaddressed. For development of analgesics, these aberrations can significantly alter the potential efficacy and/or adverse effects of a prescribed analgesic following burn trauma. We therefore suggest that a multi-model strategy would be the most clinically relevant when evaluating novel analgesics for use in burn patients. Published by Elsevier Ltd. C1 [McIntyre, Matthew K.; Clifford, John L.; Burmeister, David M.] US Army, Inst Surg Res, 3650 Chambers Pass,BHT1 Bldg 3610, Jbsa Ft Sam Houston, TX 78234 USA. [Maani, Christopher V.] Brooke Army Med Ctr, Dept Anesthesia & Operat Serv, SAUSHEC, Anesthesia Residency Program, 3551 Roger Brooke Dr, Jbsa Ft Sam Houston, TX 78234 USA. RP Burmeister, DM (reprint author), US Army, Inst Surg Res, 3650 Chambers Pass,BHT1 Bldg 3610, Jbsa Ft Sam Houston, TX 78234 USA. EM Matthew.k.mcintyre3.vol@mail.mil; John.l.clifford11.civ@mail.mil; Christopher.v.maani.civ@mail.mil; David.m.burmeister3.civ@mail.mil NR 169 TC 0 Z9 0 U1 6 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 EI 1879-1409 J9 BURNS JI Burns PD SEP PY 2016 VL 42 IS 6 BP 1161 EP 1172 DI 10.1016/j.burns.2016.01.023 PG 12 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA DW3EI UT WOS:000383524500001 PM 26906668 ER PT J AU Yun, HC Tully, CC Mende, K Castillo, M Murray, CK AF Yun, Heather C. Tully, Charla C. Mende, Katrin Castillo, Mayra Murray, Clinton K. TI A single-center, six-year evaluation of the role of pulsed-field gel electrophoresis in suspected, burn center outbreaks SO BURNS LA English DT Article DE Pulsed-field gel electrophoresis; PFGE; Burn; Epidemiology; Gram-negative bacteria; Outbreak ID ACINETOBACTER-BAUMANNII; MOLECULAR EPIDEMIOLOGY; CALCOACETICUS COMPLEX; RESISTANT; INFECTION; CULTURES; UNIT AB Introduction: Pulsed-field gel electrophoresis (PFGE) has been used as an adjunct to traditional hospital epidemiology in numerous outbreak investigations, including in burn centers. However, its most effective real-world application remains unclear, with few longitudinal descriptions of use. Setting and methods: A 425 bed military tertiary hospital with a 40 bed burn center, from July 2007 to July 2013; retrospective evaluation of hospital infection prevention records was performed and results of PFGE where used in outbreak investigation. Results: Twenty-two inquiries for suspected outbreaks were performed. 418 isolates were collected from 168 subjects during this time. 325 (78%) of the isolates originated from the burn intensive care unit. 17 inquiries were for gram-negative bacteria, comprised of 5 for Acinetobacter baumannii-calcoaceticus complex, 4 Klebsiella pneumoniae, 3 Stenotrophomonas maltophilia, 2 Pseudomonas aeruginosa, and 1 of each of the following: Enterobacter cloacae, Raoultella planticola, and Aeromonas hydrophila. The other 5 inquiries were specifically for Staphylococcus aureus. The majority of investigations revealed a combination of clonal and non-clonal isolates, and in no instance did PFGE contribute to targeting of interventions. Conclusion: PFGE contributed little to infection prevention interventions, and outbreaks resolved with increased focus on basic practices. Longitudinal studies including greater numbers of outbreaks in different settings are needed to clarify the utility of molecular typing in routine investigations. Published by Elsevier Ltd. C1 [Yun, Heather C.; Tully, Charla C.; Mende, Katrin; Murray, Clinton K.] JBSA Ft Sam Houston, San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. [Yun, Heather C.; Tully, Charla C.; Murray, Clinton K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Mende, Katrin] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biostat, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Mende, Katrin] Henry M Jackson Fdn Adv Mil Med, Rockville, MD USA. [Castillo, Mayra] JBSA Ft Sam Houston, US Army Inst Surg Res, Ft Sam Houston, TX USA. RP Yun, HC (reprint author), JBSA Ft Sam Houston, USAF MC, Infect Dis Serv, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM heather.c.yun.mil@mail.mil NR 18 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 EI 1879-1409 J9 BURNS JI Burns PD SEP PY 2016 VL 42 IS 6 BP 1323 EP 1330 DI 10.1016/j.burns.2016.03.021 PG 8 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA DW3EI UT WOS:000383524500017 PM 27180602 ER PT J AU Spencer, E Page, K Clark, MG AF Spencer, Emily Page, Kimberly Clark, Matthew G. TI Managing Frequent Relocation in Families? Considering Prospect Theory, Emotional Framing, and Priming SO FAMILY & CONSUMER SCIENCES RESEARCH JOURNAL LA English DT Article DE frequent relocation; military; prospect theory; emotional framing; anchoring; priming ID MILITARY FAMILIES; DECISION-MAKING; EXPECTED VALUE; RISK; MOBILITY; CHILDREN; BEHAVIOR; CHOICE; ADOLESCENTS; RESILIENCE AB We review the evidence and impact of relocation on outcomes in child development in civilian and military families, both those who relocate regularly and those who do not. Research with broad samples of families and conventional wisdom suggests that frequent relocation leads to negative outcomes in children. However, this observation is not consistently observed for military families or for some civilian families who regularly relocate. The reasons for these differences are not clear, but maternal attitude and parent-child interactions have been suggested as a possible moderator of relocation resilience. Nevertheless, the exact mechanisms or approach for promoting relocation resilience is not clear in the evidence base. Through an analysis of the limited available data, we propose that effectively promoting relocation resilience may involve three primary approaches and related psychological processes: (i) managing the perception of risk (based on prospect theory), (ii) emotional framing, and (iii) priming. These processes are reviewed and presented for further consideration in future research on promoting relocation resilience. C1 [Spencer, Emily; Page, Kimberly] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. [Clark, Matthew G.] Eisenhower Leader Dev Program, West Point, NY USA. [Clark, Matthew G.] US Mil Acad, West Point, NY 10996 USA. RP Clark, MG (reprint author), Dept Behav Sci & Leadership, Bldg 601,Cullum Rd, West Point, NY 10996 USA. EM matthew.clark@us.army.mil NR 49 TC 0 Z9 0 U1 5 U2 5 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1077-727X EI 1552-3934 J9 FAM CONSUM SCI RES J JI Fam. Consum. Sci. Res. J. PD SEP PY 2016 VL 45 IS 1 BP 77 EP 90 DI 10.1111/fcsr.12181 PG 14 WC Family Studies SC Family Studies GA DW7TP UT WOS:000383855200009 ER PT J AU Patel, VM Mait, JN Prather, DW Hedden, AS AF Patel, Vishal M. Mait, Joseph N. Prather, Dennis W. Hedden, Abigail S. TI Computational Millimeter Wave Imaging Problems, progress, and prospects SO IEEE SIGNAL PROCESSING MAGAZINE LA English DT Article ID OPTICAL UP-CONVERSION; EXTENDED DEPTH; SYSTEMS; ARCHITECTURE; IMAGERY; RADAR; FIELD C1 [Patel, Vishal M.] Univ Maryland, Inst Adv Comp Studies, College Pk, MD 20742 USA. [Patel, Vishal M.] Eta Kappa Nu, Piscataway, NJ USA. [Patel, Vishal M.] Pi Mu Epsilon, Piscataway, NJ USA. [Patel, Vishal M.] Phi Beta Kappa, Washington, DC USA. [Mait, Joseph N.] US Army Res Lab, Adelphi, MD USA. [Mait, Joseph N.; Prather, Dennis W.] Soc Photo Instrumentat Engineers, Bellingham, WA USA. [Mait, Joseph N.; Prather, Dennis W.] OSA, Washington, DC USA. [Mait, Joseph N.; Prather, Dennis W.] IEEE, Washington, DC USA. [Prather, Dennis W.] Univ Delaware, Elect Engn, Newark, DE 19716 USA. [Hedden, Abigail S.] US Army Res Lab, RF Technol & Integrat Branch, Sensors & Electron Devices Directorate, Adelphi, MD USA. RP Patel, VM (reprint author), Rutgers State Univ, Dept Elect & Comp Engn, New Brunswick, NJ 08901 USA. EM vishal.m.patel@rutgers.edu; joseph.n.mait2.civ@mail.mil; dprather@udel.edu; abigail.s.hedden.civ@mail.mil NR 44 TC 0 Z9 0 U1 6 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1053-5888 EI 1558-0792 J9 IEEE SIGNAL PROC MAG JI IEEE Signal Process. Mag. PD SEP PY 2016 VL 33 IS 5 BP 109 EP 118 DI 10.1109/MSP.2016.2581206 PG 10 WC Engineering, Electrical & Electronic SC Engineering GA DW9XP UT WOS:000384016400011 ER PT J AU Kalkstein, AJ MacPherson, DA AF Kalkstein, Adam J. MacPherson, Douglass A. TI Changing pressure-wind relationships for tropical cyclones in the North Atlantic and northeastern Pacific SO INTERNATIONAL JOURNAL OF CLIMATOLOGY LA English DT Article DE tropical cyclones; tropical dynamics; climatology; pressure-wind relationship; hurricanes ID DVORAK TECHNIQUE; OSCILLATION; INTENSITY; CLIMATE AB Using the National Hurricane Center's best track data, pressure-wind relationships within tropical cyclones are examined for 35 years in the North Atlantic Ocean and 26 years in the northeastern Pacific Ocean. In both ocean basins, statistically significant temporal trends exist, suggesting that storms of equal pressure have lower wind speeds today than in the past. Likewise, storms of equal wind speed have lower pressures today. Strong temporal changes in pressure-wind relationships exist among a wide range of storm strengths in the Atlantic but only for weaker storms in the Pacific. An examination of surface pressure anomalies across the two ocean basins reveals that a shifting pressure gradient is likely responsible for these observations, possibly due to macroscale pattern changes such as the North Atlantic Oscillation. C1 [Kalkstein, Adam J.; MacPherson, Douglass A.] US Mil Acad, Dept Geog & Environm Engn, 745 Brewerton Rd,6th Floor, West Point, NY 10996 USA. RP Kalkstein, AJ (reprint author), US Mil Acad, Dept Geog & Environm Engn, 745 Brewerton Rd,6th Floor, West Point, NY 10996 USA. EM Adam.Kalkstein@usma.edu NR 20 TC 0 Z9 0 U1 6 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0899-8418 EI 1097-0088 J9 INT J CLIMATOL JI Int. J. Climatol. PD SEP PY 2016 VL 36 IS 11 BP 3892 EP 3896 DI 10.1002/joc.4590 PG 5 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA DW4MB UT WOS:000383616100019 ER PT J AU Schultz, MT Smith, ER AF Schultz, Martin T. Smith, Ernest R. TI Assessing the Resilience of Coastal Systems: A Probabilistic Approach SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE Bayesian network; infrastructure networks; risk assessment; engineering resilience; community resilience; natural hazards; extreme events; lifelines; Jamaica Bay ID BAYESIAN NETWORKS; SEISMIC RESILIENCE; RELIABILITY; COMMUNITIES AB Resilience is the ability to anticipate, prepare for, and adapt to changing conditions and withstand, respond to, and recover rapidly from disruptions. Methods and tools to quantify resilience are needed to provide actionable intelligence to plan, design, construct, and manage coastal systems. This paper describes how a probabilistic measure of resilience can be assessed for a coastal community using a Bayesian network. The measure of resilience is the joint probability of meeting two management objectives, one with respect to the level of system performance and the other with respect to the length of time required to restore system performance. This paper describes a pilot study to demonstrate the approach in Jamaica Bay, New York, a dense, urban, residential community located on the southern coast of Long Island. Results of the pilot study illustrate how practical information can be developed to support decisions about managing coastal systems. The pilot study provides insights into data and information requirements; the advantages, challenges, and limitations of the approach; and the feasibility of implementing this approach for operations. This approach to resilience assessment is well suited for coastal planning contexts because it explicitly incorporates information about uncertainty in the severity of coastal storm events, as well as uncertainty in how the system will perform when exposed to storm loads. The method challenges the community to establish explicit objectives for coastal resilience, identifies what data are needed to monitor progress toward objectives, and provides a platform from which to explore how those objectives might be achieved in practice. C1 [Schultz, Martin T.] US Army, Corps Engineers, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Smith, Ernest R.] US Army, Corps Engineers, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Schultz, MT (reprint author), US Army, Corps Engineers, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM Martin.T.Schultz@usace.army.mil FU USACE FX Scott Bourne and Elizabeth Lord processed geographic information system data and created maps. Mary Anderson and Jane Smith modeled the potential effects of wetland restoration scenarios on wave heights. Jose Rullan-Rodriquez and Paul Mlakar developed fragility curves for utility infrastructure. Lisa Baron, Lynn Bocamazo, Steve Couch, Don Cresitello, Naomi Fraenkel, Caroline McCabe, Diane Rahoy, Jamal Sulayman, and Peter Weppler of USACE New York District participated in discussions to help frame the pilot demonstration. Alan Cohn of the New York City Department of Environmental Protection provided information on the water and wastewater systems. Julie Rosati provided comments on a draft version of the manuscript. Funding for this project was provided by the USACE. This study was part of an initiative by the Coastal Engineering Research Board at the request of the chief of engineers. The chief of engineers has granted permission to publish this information. NR 51 TC 0 Z9 0 U1 13 U2 13 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 EI 1551-5036 J9 J COASTAL RES JI J. Coast. Res. PD SEP PY 2016 VL 32 IS 5 BP 1032 EP 1050 DI 10.2112/JCOASTRES-D-15-00170.1 PG 19 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA DW0AQ UT WOS:000383303700004 ER PT J AU Pope, JP Miller, DL Riley, MC Anis, E Wilkes, RP AF Pope, Jenny P. Miller, Debra L. Riley, Matthew C. Anis, Eman Wilkes, Rebecca P. TI Characterization of a novel Canine distemper virus causing disease in wildlife SO JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION LA English DT Article DE Canine distemper virus; dogs; foxes; genotype; raccoons; wildlife ID RACCOON PROCYON-LOTOR; TERRESTRIAL CARNIVORES; INFECTION; ENCEPHALOMYELITIS; STRAIN; DOGS AB Canine distemper virus (CDV) is a common cause of a multisystemic disease in both domestic dogs and wildlife species, including raccoons and foxes. Outbreaks of CDV in domestic dogs in eastern Tennessee have occurred since 2012, and it was determined that these outbreaks resulted from a novel genotype of CDV. We hypothesized that this virus is also infecting area wildlife and may be a source of the virus for these outbreaks in dogs. From 2013 to 2014, autopsies were performed and tissues collected from raccoons (Procyon lotor; n = 50) and gray foxes (Urocyon cinereoargenteus; n = 8) for CDV testing. A real-time reverse transcription PCR was used to document the presence of CDV in tissue samples, and a portion of the virus was subsequently sequenced for phylogenetic analysis. A high percentage of wildlife, both with (86%) and without (55%) clinical signs, tested positive for CDV, with the majority (77%) testing positive for the novel genotype. Microscopic findings, including syncytia in the lungs and viral inclusion bodies in urothelium, astrocytes, neurons, and bronchiolar epithelium, were also consistent with canine distemper. Minimal inflammation in the central nervous system of affected animals was indicative of the acute neurologic form of the disease. Pneumonia and parasitism were also commonly found in CDV-infected animals. Based on these results, CDV appears to be prevalent in eastern Tennessee wildlife. Subclinical or clinically recovered shedders are a potential source of this novel genotype for domestic dogs, and this genotype is genetically distinct from vaccine strains. C1 [Pope, Jenny P.; Miller, Debra L.; Riley, Matthew C.; Anis, Eman; Wilkes, Rebecca P.] Univ Tennessee, Coll Vet Med, Dept Biomed & Diagnost Sci, Knoxville, TN USA. [Riley, Matthew C.] United States Army, Med Serv Corps, Knoxville, TN USA. [Anis, Eman] Univ Sadat City, Fac Vet Med, Dept Virol, Sadat City, Beheira, Egypt. [Miller, Debra L.; Wilkes, Rebecca P.] Univ Tennessee, Ctr Wildlife Hlth, Knoxville, TN USA. RP Wilkes, RP (reprint author), Univ Georgia, Coll Vet Med, Vet Diagnost & Invest Lab, POB 1389,43 Brighton Rd, Tifton, GA 31793 USA. EM beckpen@uga.edu FU Department of Biomedical and Diagnostic Sciences Education Advancement and Research Fund, College of Veterinary Medicine, The University of Tennessee FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Department of Biomedical and Diagnostic Sciences Education Advancement and Research Fund, College of Veterinary Medicine, The University of Tennessee. NR 30 TC 0 Z9 0 U1 8 U2 8 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1040-6387 EI 1943-4936 J9 J VET DIAGN INVEST JI J. Vet. Diagn. Invest. PD SEP PY 2016 VL 28 IS 5 BP 506 EP 513 DI 10.1177/1040638716656025 PG 8 WC Veterinary Sciences SC Veterinary Sciences GA DW1KA UT WOS:000383400900003 PM 27400957 ER PT J AU Carroll, MH Rosenstein, JE Foubert, JD Clark, MD Korenman, LM AF Carroll, Marjorie H. Rosenstein, Judith E. Foubert, John D. Clark, M. Diane Korenman, Lisa M. TI Rape Myth Acceptance: A Comparison of Military Service Academy and Civilian Fraternity and Sorority Students SO MILITARY PSYCHOLOGY LA English DT Article DE rape myth acceptance; military; fraternities and sororities; gender difference ID ASSAULT EDUCATION/PREVENTION PROGRAM; US NAVY PERSONNEL; SEXUAL ASSAULT; COLLEGE-STUDENTS; NATIONAL SAMPLE; WOMEN; ATTITUDES; PREVALENCE; GENDER; AGGRESSION AB Although both the military and fraternities have been theorized to be characterized by norms and attitudes that serve to legitimize violence against women, no previous work has examined the potential similarity and differences in rape-supportive beliefs of these 2 environments or the people drawn to them. Further, the belief systems of women within these organizations have received little attention. As such, the current study sought to serve as an initial exploration of the rape-supportive belief systems of people drawn to these groups. Participants were recruited from students entering 2 military service academies (U.S. Military Academy, n = 1,169, 1,003 men, 166 women; U.S. Naval Academy, n = 1,916, 1,551 men, 365 women) and fraternities and sororities at a Midwestern university (n = 393, 188 men, 205 women). All participants completed the Illinois Rape Myth Acceptance Scale-Short Form. Consistent with previous findings related to gender, men were more accepting of rape myths than women. Further, there was more variability in the levels of rape myth acceptance among military service academy and fraternity men than among military service academy and sorority women. Although across all groups the women expressed significantly lower levels of rape myth acceptance than the men, women and men from the United States Military Academy were more closely aligned in their beliefs than women and men from the other samples. Implications for sexual assault prevention education are discussed. C1 [Carroll, Marjorie H.; Korenman, Lisa M.] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. [Rosenstein, Judith E.] US Mil Acad, Dept Leadership Eth & Law, West Point, NY 10996 USA. [Foubert, John D.] Oklahoma State Univ, Sch Educ Sci, Stillwater, OK 74078 USA. [Clark, M. Diane] Gallaudet Univ, Dept Educ Fdn & Res, Washington, DC 20002 USA. RP Carroll, MH (reprint author), US Mil Acad, Dept Behav Sci & Leadership, Official Mail & Distribut Ctr, 646 Swift Rd, West Point, NY 10996 USA. EM marjorie.carroll@usma.edu NR 50 TC 0 Z9 0 U1 12 U2 12 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0899-5605 EI 1532-7876 J9 MIL PSYCHOL JI Milit. Psychol. PD SEP PY 2016 VL 28 IS 5 BP 306 EP 317 DI 10.1037/mil0000113 PG 12 WC Psychology, Multidisciplinary SC Psychology GA DW8GJ UT WOS:000383892600003 ER PT J AU Bennett, KL Shija, F Linton, YM Misinzo, G Kaddumukasa, M Djouaka, R Anyaele, O Harris, A Irish, S Hlaing, T Prakash, A Lutwama, J Walton, C AF Bennett, Kelly Louise Shija, Fortunate Linton, Yvonne-Marie Misinzo, Gerald Kaddumukasa, Martha Djouaka, Rousseau Anyaele, Okorie Harris, Angela Irish, Seth Hlaing, Thaung Prakash, Anil Lutwama, Julius Walton, Catherine TI Historical environmental change in Africa drives divergence and admixture of Aedes aegypti mosquitoes: a precursor to successful worldwide colonization? SO MOLECULAR ECOLOGY LA English DT Article DE approximate Bayesian computation; arbovirus; domestication; forest fragmentation; invasive species; Pleistocene climatic change ID YELLOW-FEVER MOSQUITO; VECTOR-BORNE DISEASES; RIFT-VALLEY COMPLEX; GENETIC-STRUCTURE; BIOLOGICAL INVASION; MITOCHONDRIAL-DNA; COMPARATIVE PHYLOGEOGRAPHY; EVOLUTIONARY HISTORY; POPULATION-GENETICS; DIPTERA-CULICIDAE AB Increasing globalization has promoted the spread of exotic species, including disease vectors. Understanding the evolutionary processes involved in such colonizations is both of intrinsic biological interest and important to predict and mitigate future disease risks. The Aedes aegypti mosquito is a major vector of dengue, chikungunya and Zika, the worldwide spread of which has been facilitated by Ae. aegypti's adaption to human-modified environments. Understanding the evolutionary processes involved in this invasion requires characterization of the genetic make-up of the source population (s). The application of approximate Bayesian computation (ABC) to sequence data from four nuclear and one mitochondrial marker revealed that African populations of Ae. aegypti best fit a demographic model of lineage diversification, historical admixture and recent population structuring. As ancestral Ae. aegypti were dependent on forests, this population history is consistent with the effects of forest fragmentation and expansion driven by Pleistocene climatic change. Alternatively, or additionally, historical human movement across the continent may have facilitated their recent spread and mixing. ABC analysis and haplotype networks support earlier inferences of a single out-of-Africa colonization event, while a cline of decreasing genetic diversity indicates that Ae. aegypti moved first from Africa to the Americas and then to Asia. ABC analysis was unable to verify this colonization route, possibly because the genetic signal of admixture obscures the true colonization pathway. By increasing genetic diversity and forming novel allelic combinations, divergence and historical admixture within Africa could have provided the adaptive potential needed for the successful worldwide spread of Ae. aegypti. C1 [Bennett, Kelly Louise; Shija, Fortunate; Walton, Catherine] Univ Manchester, Computat Evolutionary Biol Grp, Fac Life Sci, Manchester, Lancs, England. [Shija, Fortunate; Misinzo, Gerald] Sokoine Univ Agr, Dept Vet Microbiol & Parasitol, Morogoro, Tanzania. [Linton, Yvonne-Marie] Smithsonian Inst, Walter Reed Biosystemat Unit, Museum Support Ctr, Suitland, MD USA. [Linton, Yvonne-Marie] Walter Reed Army Inst Res, Silver Spring, MD USA. [Linton, Yvonne-Marie] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Linton, Yvonne-Marie] Smithsonian Inst, Dept Entomol, Natl Museum Nat Hist, NHB 169, Washington, DC 20560 USA. [Kaddumukasa, Martha; Lutwama, Julius] Uganda Virus Res Inst, Dept Arbovirol Emerging & Reemerging Infect, Entebbe, Uganda. [Djouaka, Rousseau] Int Inst Trop Agr, Agroecohlth Platform West & Cent Africa, Cotonou, Benin. [Anyaele, Okorie] Univ Ibadan, Dept Zool, Entomol Unit, Ibadan, Nigeria. [Harris, Angela] Cayman Islands Govt, Mosquito Res & Control Unit, Grand Cayman, Cayman Islands. [Irish, Seth] London Sch Hyg & Trop Med, London, England. [Hlaing, Thaung] Minist Hlth, Med Entomol Res Div, Dept Med Res Lower Myanmar, Yangon, Myanmar. [Prakash, Anil] Minist H & FW Govt India, Natl Inst Res Environm Hlth, Bhopal, India. RP Walton, C (reprint author), Univ Manchester, Computat Evolutionary Biol Grp, Fac Life Sci, Manchester, Lancs, England. EM Catherine.walton@manchester.ac.uk FU Natural Environment Research Council [NE/H525170/1, NE/1528134/1, NE/J500057/1]; Royal Society; Leverhulme Trust Africa [AA110092] FX The authors are grateful to field teams at the Uganda Virus Research Institute, International Institute for Tropical Agriculture, Vector Control Program for the Ministry of Health in Jamaica, Manatee County Mosquito District, Public Works Division in Miami-Dade County, The Florida Keys Mosquito District, Key West, and Dengue Branch of CDC in Puerto Rico and to Miriam Richards, Luke B. Mitchell and John Morgan for assistance with collection of mosquito samples. This work was supported by the Natural Environment Research Council (NE/H525170/1, NE/1528134/1, NE/J500057/1) and a Royal Society and Leverhulme Trust Africa Award (AA110092). This manuscript was prepared while YML held a National Research Council (NRC) Research Associateship Award at the Walter Reed Army Institute of Research. The material to be published reflects the views of the authors and should not be construed to represent those of the Department of the Army or the Department of Defense. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. NR 147 TC 1 Z9 1 U1 18 U2 18 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0962-1083 EI 1365-294X J9 MOL ECOL JI Mol. Ecol. PD SEP PY 2016 VL 25 IS 17 BP 4337 EP 4354 DI 10.1111/mec.13762 PG 18 WC Biochemistry & Molecular Biology; Ecology; Evolutionary Biology SC Biochemistry & Molecular Biology; Environmental Sciences & Ecology; Evolutionary Biology GA DW0PS UT WOS:000383343800016 PM 27439067 ER PT J AU Rovira, E Mackie, RS Clark, N Squire, PN Hendricks, MD Pulido, AM Greenwood, PM AF Rovira, Ericka Mackie, Ryan S. Clark, Nicholas Squire, Peter N. Hendricks, Michael D. Pulido, Alysse M. Greenwood, Pamela M. TI A Role for Attention During Wilderness Navigation: Comparing Effects of BDNF, KIBRA, and CHRNA4 SO NEUROPSYCHOLOGY LA English DT Article DE BDNF; KIBRA; CHRNA4; spatial navigation; interindividual differences ID SPATIAL KNOWLEDGE ACQUISITION; KINASE M-ZETA; VISUOSPATIAL ATTENTION; WORKING-MEMORY; INDIVIDUAL-DIFFERENCES; VAL66MET POLYMORPHISM; NEUROTROPHIC FACTOR; LARGE-SCALE; VAL(66)MET POLYMORPHISM; UNFAMILIAR NEIGHBORHOOD AB Objective: To better understand what influences interindividual differences in ability to navigate in the wilderness, we hypothesized that better performance would be seen in (a) BDNF (rs6265) Val/Val homozygotes increased use of a spatial strategy, (b) KIBRA rs17070145 T/T homozygotes superior episodic memory, (c) CHRNA4 (rs1044396) T allele carriers better ability to focus visuospatial attention. Method: Military cadets (n = 382) genotyped for BDNF, KIBRA, and CHRNA4 SNPs used a map and compass to navigate in unmarked woods. Participants completed a morning course within 3.0 km and an afternoon course within 7.0 km. Results: Success or failure in finding each point was analyzed in a logistic regression model with KIBRA, BDNF, and CHRNA4 genotypes as fixed effects. For the morning course, the adjusted odds ratio for the effect of KIBRA T/T over KIBRA C/C was 2.58 (95% CI of 1.31, 5.06) demonstrating a statistical benefit of the KIBRA T/T genotype over individuals with KIBRA C/C genotype. BDNF did not have an independent association with navigational success. For the afternoon course, the adjusted odds ratio for the effect of CHRNA4 C/T over C/C was 1.67 (95% CI of 1.24, 2.25) demonstrating a statistical benefit of CHRNA4 T allele carriers over the C/C genotype. Conclusions: Ability to navigate in the wilderness benefits less from sense of direction (BDNF and Santa Barbara Sense of Direction) and more from episodic memory (KIBRA) in the first course and heightened ability to focus attention (CHRNA4) after experience in the 2nd course. C1 [Rovira, Ericka; Pulido, Alysse M.] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. [Mackie, Ryan S.; Squire, Peter N.] Naval Surface Warfare Ctr, Dahlgren Div, Dahlgren, VA USA. [Clark, Nicholas] US Mil Acad, Dept Math, West Point, NY 10996 USA. [Hendricks, Michael D.] US Mil Acad, Dept Geog & Environm Engn, West Point, NY 10996 USA. [Greenwood, Pamela M.] George Mason Univ, Dept Psychol, Fairfax, VA 22030 USA. RP Rovira, E (reprint author), US Mil Acad, 267B Thayer Hall, West Point, NY 10996 USA. EM Ericka.Rovira@usma.edu FU Naval Surface Warfare Center, Dahlgren Division [N000141010198]; Office of Naval Research In-house Laboratory Independent Research (ILIR) FX This research was supported by the Office of Naval Research In-house Laboratory Independent Research (ILIR), Naval Surface Warfare Center, Dahlgren Division (N000141010198). NR 71 TC 0 Z9 0 U1 3 U2 3 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0894-4105 EI 1931-1559 J9 NEUROPSYCHOLOGY JI Neuropsychology PD SEP PY 2016 VL 30 IS 6 BP 709 EP 719 DI 10.1037/neu0000277 PG 11 WC Psychology, Clinical; Neurosciences; Psychology SC Psychology; Neurosciences & Neurology GA DW8BW UT WOS:000383879300006 PM 27123786 ER PT J AU Wingard, LA Guzman, PE Sabatini, JJ AF Wingard, Leah A. Guzman, Pablo E. Sabatini, Jesse J. TI A Chlorine Gas-Free Synthesis of Dichloroglyoxime SO ORGANIC PROCESS RESEARCH & DEVELOPMENT LA English DT Article AB A new procedure for the synthesis and isolation of dichloroglyoxime is discussed. This material has historically been synthesized from glyoxime and elemental chlorine gas. Chlorine gas is difficult to handle and control in the laboratory and has a high toxicity profile. Our method for making dichloroglyoxime in high purity uses glyoxime and N-chlorosuccinimide in DMF, with a lithium chloride-based workup. Overall yields are comparable with those obtained using the procedure involving the use of chlorine gas. C1 [Guzman, Pablo E.; Sabatini, Jesse J.] US Army Res Lab, Energet Technol Branch, Aberdeen Proving Ground, MD 21005 USA. [Wingard, Leah A.] Oak Ridge Associated Univ, Belcamp, MD 21017 USA. RP Sabatini, JJ (reprint author), US Army Res Lab, Energet Technol Branch, Aberdeen Proving Ground, MD 21005 USA. EM jesse.j.sabatini.civ@mail.mil FU Army Research Laboratory [W911NF-12-2-0019] FX Research sponsored by the Army Research Laboratory was accomplished in part under Cooperative Agreement Number W911NF-12-2-0019. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 11 TC 1 Z9 1 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1083-6160 EI 1520-586X J9 ORG PROCESS RES DEV JI Org. Process Res. Dev. PD SEP PY 2016 VL 20 IS 9 BP 1686 EP 1688 DI 10.1021/acs.oprd.6b00252 PG 3 WC Chemistry, Applied; Chemistry, Organic SC Chemistry GA DW4VC UT WOS:000383640100017 ER PT J AU Holley, AB Sobieszczyk, M Perkins, M Cohee, BM Costantoth, CB Mabe, DL Liotta, R Abraham, JH Holley, PR Sherner, J AF Holley, Aaron B. Sobieszczyk, Michal Perkins, Michael Cohee, Brian M. Costantoth, Camille B. Mabe, Donovan L. Liotta, Robert Abraham, Joseph H. Holley, Paul R. Sherner, John TI Lung function abnormalities among service members returning from Iraq or Afghanistan with respiratory complaints SO RESPIRATORY MEDICINE LA English DT Article DE Lung function testing; Service members; Dyspnea; Airway disease ID MONOXIDE DIFFUSING-CAPACITY; NORMAL VALUES; MILITARY; DISEASE; SPIROMETRY; POPULATION; DEPLOYMENT; EXPOSURES; SYMPTOMS; SOLDIERS AB Background: Service members deploying to Afghanistan (OEF) and Iraq (OIF) often return with respiratory symptoms. We sought to determine prevalence of lung function abnormalities following OEF/OIF. Methods: We identified OEF/OIF patients who had unexplained respiratory symptoms evaluated using lung function testing. Lung function data were summarized and analyzed for associations with demographic and deployment characteristics. Results: We found 267 patients with unexplained cough or dyspnea, lung function testing and a history of OEF/OIF deployment. All patients had basic spirometry performed and 82 had diffusion capacity for carbon dioxide (DLCO) measured. The median (IQR) number of deployments and total days deployed were 1 (1-2) and 352.0 (209-583), respectively. There were 83 (36.6%) patients with abnormal spirometry, 53 (63.9%) of whom had an abnormal FEV1/FVC. Only one (1.2%) patient had an abnormal DLCO adjusted for alveolar volume. Of 104 patients who had post bronchodilator (BD) testing performed, six (5.8%) had a positive response by ATS criteria. We found no relationships between lung function and time in theater, deployment location, deployment frequency, or land based-deployment. Dyspnea and enlisted rank were associated with tobacco use and lower FEV1, and cough was associated with total number of deployments. Conclusions: Service members with respiratory complaints following OEF/OIF have a high prevalence of abnormalities on spirometry. Tobacco use, enlisted rank and total number of deployments were associated with symptoms or spirometric abnormalities. Published by Elsevier Ltd. C1 [Holley, Aaron B.; Sobieszczyk, Michal; Perkins, Michael; Cohee, Brian M.; Mabe, Donovan L.; Sherner, John] WRNMMC, Dept Pulm Crit Care & Sleep Med, 8901 Rockville Pike, Bethesda, MD 20889 USA. [Costantoth, Camille B.] WRNMMC, Dept Internal Med, 8901 Rockville Pike, Bethesda, MD 20889 USA. [Liotta, Robert] WRNMMC, Dept Radiol, Bethesda, MD USA. [Abraham, Joseph H.] USAPHC, Occupat & Environm Med, Edgewood, MD USA. [Holley, Paul R.] US Army Med Res Inst Infect Dis, Dept Informat, Ft Detrick, MD USA. RP Holley, AB (reprint author), WRNMMC, Dept Pulm Crit Care & Sleep Med, 8901 Rockville Pike, Bethesda, MD 20889 USA. EM aholley9@gmail.com; sobiemj@gmail.com; Michael.perkins321@gmail.com; Brian.m.cohee.mil@mail.mil; Camille.b.costantoth.mil@mail.mil; Donovan.l.mabe.mil@mail.mil; Robert.A.Liotta.mil@mail.mil; joseph.h.abraham.civ@mail.mil; HolleyPR@msn.com; John.H.Sherner.mil@health.mil FU U.S. Army Medical Research and Material Command (MRMC) FX LTC Aaron B Holley has received funding from the U.S. Army Medical Research and Material Command (MRMC) to study post deployment respiratory complaints. NR 30 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO LTD PI LONDON PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND SN 0954-6111 EI 1532-3064 J9 RESP MED JI Respir. Med. PD SEP PY 2016 VL 118 BP 84 EP 87 DI 10.1016/j.rmed.2016.07.014 PG 4 WC Cardiac & Cardiovascular Systems; Respiratory System SC Cardiovascular System & Cardiology; Respiratory System GA DV9ZX UT WOS:000383301800013 PM 27578475 ER PT J AU Waterman, BR Chandler, PJ Teague, E Provencher, MT Tokish, JM Pallis, MP AF Waterman, Brian R. Chandler, Philip J. Teague, Edward Provencher, Matthew T. Tokish, John M. Pallis, Mark P. TI Short-Term Outcomes of Glenoid Bone Block Augmentation for Complex Anterior Shoulder Instability in a High-Risk Population SO ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY LA English DT Article ID LATARJET PROCEDURE; NEUROLOGIC COMPLICATIONS; SUPRASCAPULAR NERVE; HOSPITAL VOLUME; BANKART REPAIR; UNITED-STATES; BRISTOW; DISLOCATION; STABILIZATION; SURGERY AB Purpose: To describe the short-term clinical outcomes of glenoid bone block augmentation in a high-demand population, as well as to describe its clinical success and complications at greater than 2 years' follow-up in an at-risk military population. Methods: All patients undergoing anterior capsulorrhaphy with coracoid process transfer or anterior bone block augmentation (Current Procedural Terminology code 23662 or 23460) for shoulder instability between 2006 and 2012 were isolated from the Military Health System Management Analysis and Reporting Tool. Demographic and occupational parameters were identified, and multiple surgical factors and clinical outcomes were extracted from the medical record and US Defense Manpower Data Center. Results: A total of 64 service members (65 shoulders) underwent anterior bone block procedures, including coracoid transfer (n = 59, 90.8%), distal tibial allograft (n = 3, 4.6%), and autologous or allograft iliac crest bone graft (n = 3, 4.6%). This group was predominately comprised of men (n = 59), and the mean age was 25.9 years (range, 19 to 45 years). A total of 19 perioperative complications, including 8 neurologic injuries, 6 infections, and 4 hardware failures, occurred in 16 patients (25%). At a mean 2.4-year follow-up, 21 patients (32.8%) reported persistent shoulder pain and 15 patients (23.4%) disclosed subjective apprehension or recurrent instability. Secondary surgical procedures were performed in 12 patients (18.8%), including 4 revisions (6.3%). Ultimately, 20 patients (31.3%) underwent a medical discharge for persistent shoulder disability. Univariate analysis showed that the presence of a perioperative complication (P = .049) and tobacco use (P = .038) were associated with increased risk of subsequent surgical failure. Conclusions: Anterior glenoid bone block procedures for shoulder instability with concomitant bone loss enable a return to high-demand physical function. The short-term complication profile (25%), recurrence rate (23%), and persistence of shoulder pain (33%) should be emphasized during preoperative counseling, particularly in an active military population and revision setting. Although moderately successful in the military, anterior bone block procedures for complex shoulder instability can be associated with significant short-term complications and morbidity. Level of Evidence: Level IV, therapeutic case series. C1 [Waterman, Brian R.; Chandler, Philip J.; Pallis, Mark P.] William Beaumont Army Med Ctr, Dept Orthopaed Surg & Rehabil, El Paso, TX 79920 USA. [Teague, Edward] US Mil Acad, Dept Math, West Point, NY 10996 USA. [Provencher, Matthew T.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Tokish, John M.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Waterman, BR (reprint author), William Beaumont Army Med Ctr, Orthopaed Surg Serv, 5005 N Piedras St, El Paso, TX 79920 USA. EM brian.r.waterman@gmail.com FU Joint Restoration Foundation; AAOS; AOSSM; ASES; Arthroscopy; AANA; ISAKOS; Knee; Orthopedics; San Diego Shoulder Institute; SLACK; SOMOS; Arthrex; DePuy; Mitek; JSES; Orthopedics Today; Johnson Johnson FX The authors report the following potential conflict of interest or source of funding: M.T.P. receives support from Joint Restoration Foundation (Allo-source), AAOS, AOSSM, ASES, Arthroscopy, AANA, ISAKOS, Knee, Orthopedics, San Diego Shoulder Institute, SLACK, SOMOS, and Arthrex. J.M.T. receives support from DePuy, Mitek, AANA, JSES, Orthopedics Today, and Johnson & Johnson. M.P. receives support from AAOS, AANA, SOMOS, and Johnson & Johnson. NR 37 TC 4 Z9 4 U1 2 U2 2 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0749-8063 EI 1526-3231 J9 ARTHROSCOPY JI Arthroscopy PD SEP PY 2016 VL 32 IS 9 BP 1784 EP 1790 DI 10.1016/j.arthro.2016.01.051 PG 7 WC Orthopedics; Surgery SC Orthopedics; Surgery GA DV9PB UT WOS:000383272200011 PM 27132776 ER PT J AU Plahovinsak, JL Buccellato, MA Reid, FM Graham, JS AF Plahovinsak, Jennifer L. Buccellato, Matthew A. Reid, Frances M. Graham, John S. TI Selection of non-steroidal anti-inflammatory drug and treatment regimen for sulfur mustard-induced cutaneous lesions SO CUTANEOUS AND OCULAR TOXICOLOGY LA English DT Article DE Capsaicin; chemical agent; clobetasol; dermal; diclofenac; sulfur mustard; swine; therapy ID EAR VESICANT MODEL; WEANLING SWINE; SKIN; PIG; EXPOSURE; INJURY; BURNS; INFLAMMATION; DEBRIDEMENT AB The inflammatory process plays an important role in sulfur mustard (HD) injury and HD pathogenesis, suggesting that anti-inflammatory treatments applied as soon as possible following HD injury may reduce tissue damage and accelerate healing. This study used the HD dermal weanling swine model to investigate the efficacy of two non-steroidal anti-inflammatory drugs, capsaicin and diclofenac, when applied in combination with the steroid, clobetasol. The therapeutic regimen was also investigated with respect to initiation of treatment post-exposure, frequency and duration. Yorkshire-cross pigs were randomly assigned to experimental groups, corresponding to all combinations of treatment (capsaicin with clobetasol or diclofenac with clobetasol), onset time (1, 2 or 4h post-exposure), treatment duration (1, 3 or 5 days) and frequency of applications (2, 3 or 4 per day). For each animal, two sites on the ventral abdomen were exposed to 400L of neat HD for 8min to achieve superficial dermal (SD) lesions and two sites were exposed to 400L neat HD for 30min to achieve deep dermal (DD) lesions. Each treatment regimen was tested against a SD and a DD injury. Untreated SD and DD lesion sites served as within-animal controls. Assessments, up to one week post-challenge, included digital photographs, clinical assessments (lesion size measurements and modified Draize scoring), transepidermal water loss (TEWL), reflectance colorimetry and histopathologic evaluations that included an estimate for depth of injury and wound healing parameters. Diclofenac plus clobetasol treatment resulted in significant reductions in lesion contracture and modified Draize scores, increased barrier function (decreased TEWL), and increased healing as determined by histopathology for both SD and DD injury when compared with untreated sites and sites treated with capsaicin plus clobetasol. An increased duration of treatment from 1 to 5 days was most commonly associated with decreased clinical assessment and histopathological severity scores. Therefore, a combination of diclofenac and clobetasol application, when administered for at least five days, shows promise in ameliorating HD-induced lesions. C1 [Plahovinsak, Jennifer L.; Buccellato, Matthew A.; Reid, Frances M.] Battelle Mem Inst, Columbus, OH 43201 USA. [Graham, John S.] US Army, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Plahovinsak, JL (reprint author), Battelle Mem Inst, Columbus, OH 43201 USA. EM plahovinsakj@battelle.org FU DTRA/CBMS/MRMC [W81XWH-05-D-0001]; U.S. Army Medical Research Institute of Chemical Defense (USAMRICD); National Institutes of Health, National Institute of Allergies and Infectious Disease (NIAID), IAA [Y1-AI-6177-02] FX This work was conducted under DTRA/CBMS/MRMC Contract W81XWH-05-D-0001, Task Order 0010 with funding support through an Interagency Agreement (IAA) between the U.S. Army Medical Research Institute of Chemical Defense (USAMRICD) and National Institutes of Health, National Institute of Allergies and Infectious Disease (NIAID), IAA Number Y1-AI-6177-02. The views, opinions, and/or findings contained in this report are those of the authors and should not be construed as an official Department of the Army position, policy, or decision unless so designated by other documentation. The experimental protocol was approved by the Animal Care and Use Committee at Battelle Memorial Institute and the US Army Medical Research and Materiel Command's Animal Care and Use Review Office. All procedures were conducted in accordance with the principles stated in the Guide for the Care and Use of Laboratory Animals (National Research Council, 1996), and the Animal Welfare Act of 1966 (P.L. 89-544), as amended. The authors have no conflicts of interest that would affect the interpretation or conclusions of this study. NR 49 TC 0 Z9 0 U1 2 U2 2 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 1556-9527 EI 1556-9535 J9 CUTAN OCUL TOXICOL JI Cutan. Ocul. Toxicol. PD SEP PY 2016 VL 35 IS 3 BP 208 EP 217 DI 10.3109/15569527.2015.1076436 PG 10 WC Ophthalmology; Toxicology SC Ophthalmology; Toxicology GA DT2CW UT WOS:000381289400007 PM 26362124 ER PT J AU Millar, EV Schlett, CD Law, NN Chen, WJ D'Onofrio, MJ Bennett, JW Tribble, DR Ellis, MW AF Millar, Eugene V. Schlett, Carey D. Law, Natasha N. Chen, Wei-Ju D'Onofrio, Michael J. Bennett, Jason W. Tribble, David R. Ellis, Michael W. TI Reduction in Acute Respiratory Infection Among Military Trainees: Secondary Effects of a Hygiene-Based Cluster-Randomized Trial for Skin and Soft-Tissue Infection Prevention SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Article ID YOUNG-ADULTS; ILLNESS C1 [Millar, Eugene V.; Schlett, Carey D.; Law, Natasha N.; Chen, Wei-Ju; Tribble, David R.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biostat, Infect Dis Clin Res Program, Bethesda, MD USA. [Millar, Eugene V.; Schlett, Carey D.; Law, Natasha N.; Chen, Wei-Ju] Henry M Jackson Fdn Adv Mil Med, Rockville, MD USA. [Law, Natasha N.] Martin Army Community Hosp, Ft Benning, GA USA. [D'Onofrio, Michael J.] US Army, Med Res Inst Infect Dis, Div Med, Frederick, MD USA. [Bennett, Jason W.; Tribble, David R.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD USA. [Ellis, Michael W.] Univ Toledo, Coll Med & Life Sci, 2801 W Bancroft St, Toledo, OH 43606 USA. RP Millar, EV; Schlett, CD (reprint author), Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Dept Prevent Med & Biostat, 11300 Rockville Pike,Suite 1211, Rockville, MD 20852 USA. EM emillar@idcrp.org; cschlett@idcrp.org FU Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) program through Uniformed Services University of the Health Sciences; federal funds from National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) [Y1-AI-5072]; Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Division of Healthcare Quality Promotion (NCEZID-DHQP) [09FED914272] FX The work was supported by the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) program executed through the Uniformed Services University of the Health Sciences. This project was funded in part with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement (grant no. Y1-AI-5072). Additional funding was provided by Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Division of Healthcare Quality Promotion (NCEZID-DHQP); Interagency Agreement (grant no. 09FED914272 to MINE). NR 7 TC 0 Z9 0 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0899-823X EI 1559-6834 J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD SEP PY 2016 VL 37 IS 9 BP 1118 EP 1120 DI 10.1017/ice.2016.154 PG 3 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA DV4LJ UT WOS:000382896800020 PM 27387422 ER PT J AU Dobmeyer, AC Hunter, CL Corso, ML Nielsen, MK Corso, KA Polizzi, NC Earles, JE AF Dobmeyer, Anne C. Hunter, Christopher L. Corso, Meghan L. Nielsen, Matthew K. Corso, Kent A. Polizzi, Nicholas C. Earles, Jay E. TI Primary Care Behavioral Health Provider Training: Systematic Development and Implementation in a Large Medical System SO JOURNAL OF CLINICAL PSYCHOLOGY IN MEDICAL SETTINGS LA English DT Article DE Training; Integrated primary care; Collaborative primary care; Primary care behavioral health; Mental health ID PSYCHOLOGY; ADHERENCE; SERVICES AB The expansion of integrated, collaborative, behavioral health services in primary care requires a trained behavioral health workforce with specific competencies to deliver effective, evidence-informed, team-based care. Most behavioral health providers do not have training or experience working as primary care behavioral health consultants (BHCs), and require structured training to function effectively in this role. This article discusses one such training program developed to meet the needs of a large healthcare system initiating widespread implementation of the primary care behavioral health model of service delivery. It details the Department of Defense's experience in developing its extensive BHC training program, including challenges of addressing personnel selection and hiring issues, selecting a model for training, developing and implementing a phased training curriculum, and improving the training over time to address identified gaps. Future directions for training improvements and lessons learned in a large healthcare system are discussed. C1 [Dobmeyer, Anne C.; Corso, Kent A.] Def Ctr Excellence Psychol Hlth & Traumat Brain I, Deployment Hlth Clin Ctr, 1335 East West Highway,3rd Floor, Silver Spring, MD 20910 USA. [Hunter, Christopher L.] Def Hlth Agcy, Patient Ctr Med Home Branch, Falls Church, VA USA. [Corso, Meghan L.] Navy Bur Med & Surg, Behav Hlth Integrat Program, Falls Church, VA USA. [Nielsen, Matthew K.] Air Force Med Operat Agcy, Behav Hlth Optimizat Program, San Antonio, TX USA. [Polizzi, Nicholas C.] Natl Capital Reg Med Directorate, Behav Hlth Patient Ctr Med Home, Bethesda, MD USA. [Corso, Kent A.] Uniformed Serv Univ Hlth Sci, Dept Family Med, Bethesda, MD 20814 USA. [Earles, Jay E.] Dwight D Eisenhower Army Med Ctr, Dept Behav Hlth, Ft Gordon, GA USA. RP Dobmeyer, AC (reprint author), Def Ctr Excellence Psychol Hlth & Traumat Brain I, Deployment Hlth Clin Ctr, 1335 East West Highway,3rd Floor, Silver Spring, MD 20910 USA. EM anne.c.dobmeyer.mil@mail.mil NR 26 TC 0 Z9 0 U1 3 U2 3 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9583 EI 1573-3572 J9 J CLIN PSYCHOL MED S JI J. Clin. Psychol. Med. Settings PD SEP PY 2016 VL 23 IS 3 BP 207 EP 224 DI 10.1007/s10880-016-9464-9 PG 18 WC Psychology, Clinical SC Psychology GA DU3SL UT WOS:000382132400001 PM 27484777 ER PT J AU Guthrie, WS Shoop, SA Ulring, JD AF Guthrie, W. Spencer Shoop, Sally A. Ulring, Joel D. TI Frost Damage in Pavement: Causes and Cures SO JOURNAL OF COLD REGIONS ENGINEERING LA English DT Editorial Material DE Frost action; Frost damage; Frost heave; Pavement damage; Seasonal frost; Thaw weakening AB Forum papers are thought-provoking opinion pieces or essays founded in fact, sometimes containing speculation, on a civil engineering topic of general interest and relevance to the readership of the journal. The views expressed in this Forum article do not necessarily reflect the views of ASCE or the Editorial Board of the journal. C1 [Guthrie, W. Spencer] Brigham Young Univ, Dept Civil & Environm Engn, 368 Clyde Bldg, Provo, UT 84602 USA. [Shoop, Sally A.] ERDC CRREL, 72 Lyme Rd, Hanover, NH 03755 USA. [Ulring, Joel D.] Minnesota Dept Transportat, 395 John Ireland Blvd,MS 500, St Paul, MN 55155 USA. RP Ulring, JD (reprint author), Minnesota Dept Transportat, 395 John Ireland Blvd,MS 500, St Paul, MN 55155 USA. EM guthrie@byu.edu; Sally.a.shoop@usace.army.mil; joel.ulring@state.mn.us NR 3 TC 0 Z9 0 U1 6 U2 6 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0887-381X EI 1943-5495 J9 J COLD REG ENG JI J. Cold Reg. Eng. PD SEP PY 2016 VL 30 IS 3 AR 02516001 DI 10.1061/(ASCE)CR.1943-5495.0000110 PG 2 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA DV7TS UT WOS:000383141000003 ER PT J AU Winn, AE Spillane, EL Peterson, DJ Sperling, LC Meyerle, JH AF Winn, Aubrey E. Spillane, Erin L. Peterson, Dave J. Sperling, Leonard C. Meyerle, Jon H. TI False-negative direct immunofluorescence testing in vancomycin-induced linear IgA bullous dermatosis: a diagnostic pitfall SO JOURNAL OF CUTANEOUS PATHOLOGY LA English DT Letter DE false-negative; direct immunofluorescence testing; linear IgA bullous dermatosis; vancomycin; repeat biopsy C1 [Winn, Aubrey E.; Sperling, Leonard C.; Meyerle, Jon H.] Uniformed Serv Univ Hlth Sci, Dept Dermatol, Bethesda, MD 20814 USA. [Spillane, Erin L.] Womack Army Med Ctr, Dept Dermatol, Ft Bragg, NC USA. [Peterson, Dave J.] Womack Army Med Ctr, Dept Pathol, Ft Bragg, NC USA. RP Meyerle, JH (reprint author), Uniformed Serv Univ Hlth Sci, Dept Dermatol, Bethesda, MD 20814 USA. EM jon.meyerle@usuhs.edu NR 2 TC 0 Z9 0 U1 1 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0303-6987 EI 1600-0560 J9 J CUTAN PATHOL JI J. Cutan. Pathol. PD SEP PY 2016 VL 43 IS 9 BP 802 EP 804 DI 10.1111/cup.12742 PG 3 WC Dermatology; Pathology SC Dermatology; Pathology GA DV5RC UT WOS:000382984400013 PM 27354289 ER PT J AU Barocas, V Tenorio, LM Devine, K Lee, J Sweet, R Norfleet, J Mazzeo, M AF Barocas, Victor Tenorio, Luis Morales Devine, Kelsey Lee, Jayme Sweet, Robert Norfleet, Jack Mazzeo, Mark TI A Paradigm for Materials Design for Surgical Simulators, With Specific Application to the Pleura and Needle Decompression SO JOURNAL OF MEDICAL DEVICES-TRANSACTIONS OF THE ASME LA English DT Article; Proceedings Paper CT University-of-Minnesota's Design of Medical Devices (DMD) Conference CY APR 11-14, 2016 CL Minneapolis, MN SP Univ Minnesota C1 [Barocas, Victor; Tenorio, Luis Morales; Devine, Kelsey; Lee, Jayme] Univ Minnesota, Dept Biomed Engn, Minneapolis, MN 55455 USA. [Sweet, Robert] Univ Washington, Dept Urol Surg, Seattle, WA 98915 USA. [Norfleet, Jack; Mazzeo, Mark] Army Res Lab, Orlando, FL 32826 USA. RP Barocas, V (reprint author), Univ Minnesota, Dept Biomed Engn, Minneapolis, MN 55455 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 1932-6181 EI 1932-619X J9 J MED DEVICES JI J. Med. Devices PD SEP PY 2016 VL 10 IS 3 AR 030934 DI 10.1115/1.4033854 PG 2 WC Engineering, Biomedical SC Engineering GA DV8KC UT WOS:000383184900035 ER PT J AU Shen, YH Norfleet, J Zhao, ZC Hananel, D Burke, D Reihsen, T Sweet, R AF Shen, Yunhe Norfleet, Jack Zhao, Zichen Hananel, David Burke, Daniel Reihsen, Troy Sweet, Robert TI High-Fidelity Medical Training Model Augmented With Virtual Reality and Conformable Sensors SO JOURNAL OF MEDICAL DEVICES-TRANSACTIONS OF THE ASME LA English DT Article; Proceedings Paper CT University-of-Minnesota's Design of Medical Devices (DMD) Conference CY APR 11-14, 2016 CL Minneapolis, MN SP Univ Minnesota ID ENDOTRACHEAL INTUBATION C1 [Shen, Yunhe; Zhao, Zichen; Hananel, David; Burke, Daniel; Reihsen, Troy; Sweet, Robert] Univ Minnesota, CREST, Minneapolis, MN 55455 USA. [Norfleet, Jack] Army Res Lab, RDECOM, Adelphi, MD 20783 USA. RP Shen, YH (reprint author), Univ Minnesota, CREST, Minneapolis, MN 55455 USA. NR 10 TC 0 Z9 0 U1 4 U2 4 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 1932-6181 EI 1932-619X J9 J MED DEVICES JI J. Med. Devices PD SEP PY 2016 VL 10 IS 3 AR 030915 DI 10.1115/1.4033847 PG 3 WC Engineering, Biomedical SC Engineering GA DV8KC UT WOS:000383184900016 ER PT J AU Zander, NE Piehler, T Banton, R Benjamin, R AF Zander, Nicole E. Piehler, Thuvan Banton, Rohan Benjamin, Richard TI Effects of Repetitive Low-Pressure Explosive Blast on Primary Neurons and Mixed Cultures SO JOURNAL OF NEUROSCIENCE RESEARCH LA English DT Article DE primary blast; mild traumatic brain injury; in vitro model; primary cultures; repetitive blast ID TRAUMATIC BRAIN-INJURY; IN-VITRO MODEL; MECHANICAL STRETCH; NEUROTRAUMA; DAMAGE; TBI; EXPRESSION; DEATH AB Repetitive mild traumatic brain injury represents a considerable health concern, particularly for athletes and military personnel. For blast-induced brain injury, threshold shock-impulse levels required to induce such injuries and cumulative effects with single and/or multiple exposures are not well characterized. Currently, there is no established in vitro experimental model with blast pressure waves generated by live explosives. This study presents results of primary neurons and mixed cultures subjected to our unique in vitro indoor experimental platform that uses real military explosive charges to probe the effects of primary explosive blast at the cellular level. The effects of the blast on membrane permeability, generation of reactive oxygen species (ROS), uptake of sodium ions, intracellular calcium, and release of glutamate were probed 2 and 24 hr postblast. Significant changes in membrane permeability and sodium uptake among the sham, singleblast-injured, and triple-blast-injured samples were observed. A significant increase in ROS and glutamate release was observed for the triple-blast-injured samples compared with the sham. Changes in intracellular calcium were not significant. These results suggest that blast exposure disrupts the integrity of the plasma membrane, leading to the upset of ion homeostasis, formation of ROS, and glutamate release. Published 2016. dagger This article is a U.S. Government work and is in the public domain in the USA C1 [Zander, Nicole E.; Piehler, Thuvan; Banton, Rohan; Benjamin, Richard] US Army Res Lab, Weap & Mat Res Directorate, Bldg 4600, Aberdeen, MD 21005 USA. RP Zander, NE (reprint author), US Army Res Lab, Dept Army, RDRL WMM G, Bldg 4600, Aberdeen, MD 21005 USA. EM nicole.e.zander.civ@mail.mil FU U.S. Army Research Laboratory's Director's Strategic Initiative [DSI-13-WMR-2D-005] FX Contract grant sponsor: U.S. Army Research Laboratory's Director's Strategic Initiative; Contract grant number: DSI-13-WMR-2D-005. NR 40 TC 1 Z9 1 U1 7 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0360-4012 EI 1097-4547 J9 J NEUROSCI RES JI J. Neurosci. Res. PD SEP PY 2016 VL 94 IS 9 BP 827 EP 836 DI 10.1002/jnr.23786 PG 10 WC Neurosciences SC Neurosciences & Neurology GA DV9SU UT WOS:000383282900007 PM 27317559 ER PT J AU Ernat, JJ Knox, JB Wimberly, RL Riccio, AI AF Ernat, Justin J. Knox, Jeffrey B. Wimberly, Robert L. Riccio, Anthony I. TI The Effects of Restraint Type on Pattern of Spine Injury in Children SO JOURNAL OF PEDIATRIC ORTHOPAEDICS LA English DT Article DE pediatric; spine trauma; fracture; motor vehicle collision; restraint; seatbelt; car seat ID MOTOR-VEHICLE COLLISIONS; SEAT-BELT INJURIES; PASSENGER SAFETY; CHANCE FRACTURES; YOUNG-CHILDREN; CRASHES; REDUCTION; AGE AB Introduction: While the use of vehicular restraints has reduced the morbidity and mortality of children involved in motor vehicle collisions (MVC), to our knowledge, no study has examined the relationship between restraint type and patterns of pediatric spinal injuries. The purpose of this study is to evaluate this association and review the spinal injuries sustained in children involved in MVC. Methods: We completed an IRB-approved, retrospective chart review of all patients below 10 years of age presenting to a level 1 pediatric trauma hospital with spine injuries sustained in MVC from 2003 to 2011. We reviewed prehospital data, medical records, and radiographs to establish the restraint type and characterize the spinal injuries sustained. Results: A total of 97 patients were identified with spinal trauma secondary to MVC with appropriate and documentation of restraint type. Results are reported regardless of whether the restraint employed was properly used per established guidelines. Car seat/booster seat (C/B) patients sustained significantly higher rates of cervical spine (62%) and ligamentous (62%) injuries than the 2-point (2P) (10%) and 3-point (3P) restraint (24%) groups (P < 0.001). Two-point and 3P restraint use was associated with significantly higher rates of thoracolumbar injuries (67% and 62%, respectively) than the C/B (14%) and unrestrained (0%) groups (P < 0.001). Two-point and 3P passengers also had a higher rate of flexion-distraction injuries (P < 0.001). Patients in the unrestrained group sustained a significantly higher rate of cervical spine (80%) and ligamentous (40%) injuries than the 2P and 3P groups (P < 0.001). No differences were found in the type or location of injury between the 2P and 3P groups. Significant differences in proper restraint use were identified between age groups with younger children demonstrating higher rates of proper restraint use (P < 0.01). Conclusions: Two-point or 3P seatbelt use is associated with lower rates of cervical spine trauma but higher rates of thoracic and lumbar trauma, particularly flexion-distraction injuries, when compared with car or booster seats. Children in C/B and those who are unrestrained sustain high rates of cervical spine injury. C1 [Ernat, Justin J.; Knox, Jeffrey B.] Tripler Army Med Ctr, Orthoped Surg Serv, Honolulu, HI 96859 USA. [Wimberly, Robert L.; Riccio, Anthony I.] Texas Scottish Rite Hosp Children, Dept Orthoped, 2222 Welborn St, Dallas, TX 75219 USA. [Wimberly, Robert L.; Riccio, Anthony I.] Childrens Med Ctr, Dallas, TX 75235 USA. RP Riccio, AI (reprint author), Texas Scottish Rite Hosp Children, 2222 Welborn St, Dallas, TX 75219 USA. EM anthony.riccio@tsrh.org NR 24 TC 1 Z9 1 U1 2 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0271-6798 EI 1539-2570 J9 J PEDIATR ORTHOPED JI J. Pediatr. Orthop. PD SEP PY 2016 VL 36 IS 6 BP 594 EP 601 DI 10.1097/BPO.0000000000000502 PG 8 WC Orthopedics; Pediatrics SC Orthopedics; Pediatrics GA DT2OK UT WOS:000381319800010 PM 25887833 ER PT J AU Camacho, M Li, DC Kawai, M Zaghi, S Teixeira, J Senchak, AJ Brietzke, SE Frasier, S Certal, V AF Camacho, Macario Li, Dongcai Kawai, Makoto Zaghi, Soroush Teixeira, Jeffrey Senchak, Andrew J. Brietzke, Scott E. Frasier, Samuel Certal, Victor TI Tonsillectomy for adult obstructive sleep apnea: A systematic review and meta-analysis SO LARYNGOSCOPE LA English DT Review DE Tonsillectomy; obstructive sleep apnea; sleep apnea syndromes; meta-analysis; systematic review ID TONSILLAR HYPERTROPHY; NASAL SURGERY; UPPER AIRWAY; TRACHEOSTOMY; PARAMETERS; MANAGEMENT; SCALE; NOSE AB Objectives/HypothesisTo determine if sleepiness and sleep study variables (e.g., Apnea-Hypopnea Index [AHI] and lowest oxygen saturation) improve following isolated tonsillectomy for adult obstructive sleep apnea (OSA). Study DesignSystematic review and meta-analysis. MethodsNine databases (PubMed/MEDLINE included) were searched through November 24, 2015. ResultsSeventeen studies (n = 216 patients, 34.4 10.0 years and body mass index: 29.0 +/- 6.1 kg/m(2)) met criteria. Tonsils sizes were hypertrophied, large, enlarged, extremely enlarged, or grades 2 to 4. Apnea-Hypopnea Index decreased by 65.2% (from 40.5 +/- 28.9/hour to 14.1 +/- 17.1/hour) (n = 203). The AHI mean difference (MD) was -30.2 per hour (95% confidence interval [CI] -39.3, -21.1) (P value < 0.00001). The AHI SMD was -1.37 (-1.65, -1.09) (large effect). Lowest oxygen saturation improved from 77.7 +/- 11.9% to 85.5 +/- 8.2% (n = 186). Lowest oxygen saturation MD was 8.5% (95% CI 5.2, 11.8) (P value < 0.00001). The Epworth Sleepiness Scale decreased from 11.6 +/- 3.7 to 6.1 +/- 3.9 (P value < 0.00001) (n = 125). Individual patient outcomes (n = 54) demonstrated an 85.2% success rate (AHI < 20/hour and 50% reduction) and a 57.4% cure rate. Individual patient data meta-analysis showed preoperative AHI < 30 per hour to be a significant predictor of surgical success (P value < 0.001) and cure (P value = 0.043); among patients with preoperative AHI < 30 per hour, tonsillectomy success rate was 100% (25 of 25) and cure rate was 84% (21 of 25) with a mean postoperative AHI of 2.4 +/- 2.1 per hour; this compares to tonsillectomy success rate of 72.4% (21 of 29), cure rate of 10 of 29 (34.4%), and mean postoperative AHI of 14.3 +/- 13.9 per hour for patients with preoperative AHI 30 per hour. ConclusionIsolated tonsillectomy can be successful as treatment for adult OSA, especially among patients with large tonsils and mild to moderate OSA (AHI < 30/hour). Laryngoscope, 2016 Laryngoscope, 126:2176-2186, 2016 C1 [Camacho, Macario] Tripler Army Med Ctr, Div Sleep Surg & Med, Dept Otolaryngol Head & Neck Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. [Camacho, Macario] Stanford Hosp & Clin, Sleep Med Div, Dept Psychiat & Behav Sci, Stanford, CA USA. [Li, Dongcai] Inst ENT, Shenzhen Key Lab ENT, Shenzhen, Peoples R China. [Li, Dongcai] Longgang ENT Hosp, Shenzhen, Peoples R China. [Kawai, Makoto] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA. [Kawai, Makoto] VA Palo Alto Hlth Care Syst, Sierra Pacific Mental Illness Res Educ Ctr, Palo Alto, CA USA. [Kawai, Makoto] VA Palo Alto Hlth Care Syst, Sierra Pacific Mental Illness Clin Ctr, Palo Alto, CA USA. [Zaghi, Soroush] Univ Calif Los Angeles, David Geffen Sch Med, Dept Head & Neck Surg, Los Angeles, CA 90095 USA. [Teixeira, Jeffrey; Senchak, Andrew J.; Brietzke, Scott E.] Walter Reed Natl Mil Med Ctr, Dept Otolaryngol Head & Neck Surg, Bethesda, MD USA. [Frasier, Samuel] Naval Med Ctr Portsmouth, Dept Otolaryngol Head & Neck Surg, Portsmouth, VA USA. [Certal, Victor] Hosp CUF & CHEDV Porto, Dept Otorhinolaryngol, Sleep Med Ctr, Oporto, Portugal. [Certal, Victor] Univ Porto, CINTESIS Ctr Res Hlth Technol & Informat Syst, Oporto, Portugal. RP Camacho, M (reprint author), Tripler Army Med Ctr, Div Sleep Surg & Med, Dept Otolaryngol Head & Neck Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM drcamachoent@yahoo.com RI FMUP, CINTESIS/C-6631-2014 OI FMUP, CINTESIS/0000-0001-7248-2086 NR 73 TC 1 Z9 1 U1 1 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0023-852X EI 1531-4995 J9 LARYNGOSCOPE JI Laryngoscope PD SEP PY 2016 VL 126 IS 9 BP 2176 EP 2186 DI 10.1002/lary.25931 PG 11 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA DV9VD UT WOS:000383289400051 PM 27005314 ER PT J AU Albers, M Zhu, S Ayangeakaa, AD Janssens, RVF Gellanki, J Ragnarsson, I Alcorta, M Baugher, T Bertone, PF Carpenter, MP Chiara, CJ Chowdhury, P David, HM Deacon, AN DiGiovine, B Gade, A Hoffman, CR Kondev, FG Lauritsen, T Lister, CJ McCutchan, EA Nair, C Rogers, AM Seweryniak, D AF Albers, M. Zhu, S. Ayangeakaa, A. D. Janssens, R. V. F. Gellanki, J. Ragnarsson, I. Alcorta, M. Baugher, T. Bertone, P. F. Carpenter, M. P. Chiara, C. J. Chowdhury, P. David, H. M. Deacon, A. N. DiGiovine, B. Gade, A. Hoffman, C. R. Kondev, F. G. Lauritsen, T. Lister, C. J. McCutchan, E. A. Nair, C. Rogers, A. M. Seweryniak, D. TI Single-particle and collective excitations in Ni-62 SO PHYSICAL REVIEW C LA English DT Article ID ROTATIONAL BANDS; TERMINATION; ISOTOPES; NUCLEUS; DECAY AB Background: Level sequences of rotational character have been observed in several nuclei in the A = 60 mass region. The importance of the deformation-driving pi f(7/2) and nu g(9/2) orbitals on the onset of nuclear deformation is stressed. Purpose: A measurement was performed in order to identify collective rotational structures in the relatively neutron-rich Ni-62 isotope. Method: The Mg-26(Ca-48,2 alpha 4n gamma)Ni-62 complex reaction at beam energies between 275 and 320 MeV was utilized. Reaction products were identified in mass (A) and charge (Z) with the fragment mass analyzer (FMA) and gamma rays were detected with the Gammasphere array. Results: Two collective bands, built upon states of single-particle character, were identified and sizable deformation was assigned to both sequences based on the measured transitional quadrupole moments, herewith quantifying the deformation at high spin. Conclusions: Based on cranked Nilsson-Strutinsky calculations and comparisons with deformed bands in the A = 60 mass region, the two rotational bands are understood as being associated with configurations involving multiple f(7/2) protons and g(9/2) neutrons, driving the nucleus to sizable prolate deformation. C1 [Albers, M.; Zhu, S.; Ayangeakaa, A. D.; Janssens, R. V. F.; Alcorta, M.; Bertone, P. F.; Carpenter, M. P.; Chiara, C. J.; David, H. M.; DiGiovine, B.; Hoffman, C. R.; Lauritsen, T.; Lister, C. J.; McCutchan, E. A.; Nair, C.; Rogers, A. M.; Seweryniak, D.] Argonne Natl Lab, Div Phys, Argonne, IL 60439 USA. [Gellanki, J.] Univ Groningen, KVI CART, NL-9747 AA Groningen, Netherlands. [Ragnarsson, I.] Lund Univ, LTH, Div Math Phys, S-22100 Lund, Sweden. [Baugher, T.; Gade, A.] Michigan State Univ, Natl Superconducting Cyclotron Lab, E Lansing, MI 48824 USA. [Baugher, T.; Gade, A.] Michigan State Univ, Dept Phys & Astron, E Lansing, MI 48824 USA. [Chiara, C. J.] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA. [Chowdhury, P.; Lister, C. J.; Rogers, A. M.] Univ Massachusetts Lowell, Dept Phys, Lowell, MA 01854 USA. [Deacon, A. N.] Univ Manchester, Sch Phys & Astron, Manchester M13 9PL, Lancs, England. [Kondev, F. G.] Argonne Natl Lab, Nucl Engn Div, 9700 S Cass Ave, Argonne, IL 60439 USA. [Alcorta, M.] TRIUMF, 4004 Wesbrook Mall, Vancouver, BC V6T 2A3, Canada. [Bertone, P. F.] Marshall Space Flight Ctr, Bldg 4600 Rideout Rd, Huntsville, AL 35812 USA. [Chiara, C. J.] US Army Res Lab, Adelphi, MD 20783 USA. [David, H. M.] GSI Helmholtzzentrum Schwerionenforsch GmbH, D-64291 Darmstadt, Germany. [McCutchan, E. A.] Brookhaven Natl Lab, Natl Nucl Data Ctr, Upton, NY 11973 USA. RP Albers, M (reprint author), Argonne Natl Lab, Div Phys, Argonne, IL 60439 USA. RI Gade, Alexandra/A-6850-2008 OI Gade, Alexandra/0000-0001-8825-0976 FU US Department of Energy, Office of Science, Office of Nuclear Physics [DE-AC02-06CH11357, DE-FG02-94ER40834, DE-FG02-94ER40848, DE-FG02-08ER41556]; National Science Foundation [PHY-1102511]; Swedish Research Council; United Kingdom Science and Technology Facilities Council (STFC) FX The authors thank J. P. Greene (ANL) for target preparation and the ATLAS operations staff for the efficient running of the accelerator during the experiment. This work was supported in part by the US Department of Energy, Office of Science, Office of Nuclear Physics, under Contract No. DE-AC02-06CH11357 and Grant Nos. DE-FG02-94ER40834, DE-FG02-94ER40848, and DE-FG02-08ER41556, by the National Science Foundation under Contract No. PHY-1102511, by the Swedish Research Council, and by the United Kingdom Science and Technology Facilities Council (STFC). This research used resources of ANL's ATLAS facility, which is a DOE Office of Science User Facility. NR 53 TC 0 Z9 0 U1 2 U2 2 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9985 EI 2469-9993 J9 PHYS REV C JI Phys. Rev. C PD SEP 1 PY 2016 VL 94 IS 3 AR 034301 DI 10.1103/PhysRevC.94.034301 PG 10 WC Physics, Nuclear SC Physics GA DV6KZ UT WOS:000383045700001 ER PT J AU Wax, SG Stankorb, SM AF Wax, Sarah Grenier Stankorb, Susan M. TI Prevalence of food insecurity among military households with children 5 years of age and younger SO PUBLIC HEALTH NUTRITION LA English DT Article DE Food security; Military; Active duty; Children ID UNITED-STATES; US ADULTS; HEALTH; FAMILIES; MOTHERS; QUALITY; HUNGER AB Objective Food insecurity increases risk of health conditions that may decrease military readiness. The aim of the present study was to define the prevalence of food insecurity among households with young children utilizing military installation childcare facilities and to describe household characteristics associated with food insecurity among this population. Design Cross-sectional survey including demographic questions and the US Department of Agriculture Food Security Survey Module six-item short form given to households (n 248) enrolled in Joint Base San Antonio Child Development Centers (JBSA-CDC) during the spring of 2015. Subjects Department of Defense families with at least one child less than 6 years old enrolled in a JBSA-CDC. Settings Joint Base San Antonio, TX, USA. Results Nearly one in seven families reported food insecurity. Households were more likely to be food-insecure if the head of household's highest level of education was high school or equivalent (P=0003) and if the head of household was unmarried/unpartnered (P=0001). Among food-insecure households headed by military service members, all were junior enlisted or non-commissioned officers (E1-E9). Food-insecure households were less likely to live off-post in owned or rented homes compared with those who were food-secure (P=0016). Other characteristics associated with food insecurity included at least one family member enrolled in the Exceptional Family Member Program (P=0020) and more children in the household (P=0029). Few families reported enrolment in government supplemental food programmes. Conclusions Food insecurity is prevalent in military families. Targeted interventions and policies can be developed using the demographic risk factors identified in the present study. C1 [Wax, Sarah Grenier] AMEDD Ctr & Sch, Mil Baylor Grad Program Nutr, 3599 Winfield Scott Rd,Suite 308, San Antonio, TX 78234 USA. [Stankorb, Susan M.] Brooke Army Med Ctr, Dept Med Nutr, San Antonio, TX 78219 USA. RP Wax, SG (reprint author), AMEDD Ctr & Sch, Mil Baylor Grad Program Nutr, 3599 Winfield Scott Rd,Suite 308, San Antonio, TX 78234 USA. EM sarah.g.wax.mil@mail.mil FU Retired Army Medical Specialist Corps Association FX This work was supported by the Retired Army Medical Specialist Corps Association. Funding was provided for participation incentives. The funder had no role in the design, analysis or writing of this article. NR 53 TC 0 Z9 0 U1 3 U2 3 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 1368-9800 EI 1475-2727 J9 PUBLIC HEALTH NUTR JI Public Health Nutr. PD SEP PY 2016 VL 19 IS 13 BP 2458 EP 2466 DI 10.1017/S1368980016000422 PG 9 WC Public, Environmental & Occupational Health; Nutrition & Dietetics SC Public, Environmental & Occupational Health; Nutrition & Dietetics GA DV4IK UT WOS:000382889000020 PM 26976798 ER PT J AU Gultepe, I Fernando, HJS Pardyjak, ER Hoch, SW Silver, Z Creegan, E Leo, LS Pu, ZX De Wekker, SFJ Hang, CX AF Gultepe, I. Fernando, H. J. S. Pardyjak, E. R. Hoch, S. W. Silver, Z. Creegan, E. Leo, L. S. Pu, Zhaoxia De Wekker, S. F. J. Hang, Chaoxun TI An Overview of the MATERHORN Fog Project: Observations and Predictability SO PURE AND APPLIED GEOPHYSICS LA English DT Article DE Ice fog; aviation; fog forecasting; microphysics; fog measurements; visibility; mountain weather; remote sensing; lidar; sodar ID ICE FOG; CLOUD; MODEL; PARAMETERIZATIONS; VISIBILITY; AIRCRAFT; MICROPHYSICS; FIRE AB A field campaign design to study fog processes in complex terrain was a component of the Mountain Terrain Atmospheric Modeling and Observations (MATERHORN) Program. The experiment was conducted in the Wasatch Mountains during January 5-February 15, 2015. Fog and in particular, Ice fog (IF), defined as fog composed of only ice crystals, was studied during a part of the campaign, and this component of the program was dubbed MATERHORN-Fog. Ice fog often occurs in mountainous regions due do rapid cooling, such as radiative cooling, advective cooling, and cooling associated with mountain circulations (e.g., slope and valley winds). A variety of major instrument platforms were deployed, which included meteorological towers, a SODAR, a LiDAR, ceilometers, and a tethersonde profiler. In addition, in situ measurements took place at several locations surrounding Salt Lake City and Heber City. During the campaign, ice fog occurred at temperatures below -5 A degrees C down to -13 A degrees C and lasted for several hours until radiative heating became significant. The visibility (Vis) during ice fog events ranged from 100 m up to 10 km. At the Heber City site an array of sensors for measuring microphysical, radiative, and dynamical characteristics of IF events were deployed. Some local effects such as upslope advection were observed to affect the IF conditions. As expected during these events, ice water content (IWC) varied from 0.01 up to 0.2 g m(-3), with radiative cooling fluxes as strong as 200 W m(-2); turbulent heat and moisture fluxes were significantly lower during fog events than those of fog dissipation. At times, the measured ice crystal number concentration was as high as 100 cm(-3) during periods of saturation with respect to ice. N (i) was not a constant as usually assumed in forecasting simulations, but rather changed with increasing IWC. Measurement based statistics suggested that the occurrence of IF events in the region was up to 30 % during the study period in the winter of 2015. Temperature profiles suggested that an inversion layer contributed significantly to IF formation at Heber. Ice fog forecasts via Weather Research and Forecasting (WRF) model indicated the limitations of IF predictability. Results suggest that IF predictions need to be improved based on ice microphysical parameterizations and ice nucleation processes. C1 [Gultepe, I.] Environm Canada, Meteorol Res Div, Cloud Phys & Severe Weather Res Sect, Toronto, ON M3H 5T4, Canada. [Fernando, H. J. S.; Silver, Z.; Leo, L. S.] Univ Notre Dame, Civil & Environm Engn & Earth Sci, Environm Fluid Dynam Labs, Notre Dame, IN 46556 USA. [Pardyjak, E. R.; Hang, Chaoxun] Univ Utah, Environm Fluid Dynam Lab, Mech Eng Dept, Salt Lake City, UT USA. [Hoch, S. W.; Pu, Zhaoxia] Univ Utah, Dept Atmospher Sci, Salt Lake City, UT USA. [Creegan, E.] US Army Res Lab, White Sands Missile Range, White Sands Missile Range, NM USA. [De Wekker, S. F. J.] Univ Virginia, Dept Environm Sci, Clark Hall, Charlottesville, VA 22903 USA. [Fernando, H. J. S.] Univ Notre Dame, Dept Aerosp & Mech Engn, Notre Dame, IN 46556 USA. RP Gultepe, I (reprint author), Environm Canada, Meteorol Res Div, Cloud Phys & Severe Weather Res Sect, Toronto, ON M3H 5T4, Canada. EM ismail.gultepe@canada.ca RI Leo, Laura/J-9529-2013 OI Leo, Laura/0000-0003-4103-6862 FU Office of Naval Research (MURI) [N00014-11-1-0709]; Cloud Physics and Severe Weather Section of the Environment Canada, Toronto, Ontario, Canada; Wayne and Diana Murdy Family Endowment at Notre Dame FX The MATERHORN Program was funded by the Office of Naval Research (MURI) Award N00014-11-1-0709 (Program Officers: Drs. Ronald Ferek and Daniel Eleuterio). The first author's involvement in this work and technical assistance provided by Mr. Michael Harwood were partially funded by the Cloud Physics and Severe Weather Section of the Environment Canada, Toronto, Ontario, Canada. The decision of Environment Canada to participate in the campaign is gratefully acknowledged. Additional funding was provided by Wayne and Diana Murdy Family Endowment at Notre Dame. The National Center for Atmospheric Research loaned nephelometers for this study, and the assistance of Mike Reeves and Steve Oncley at NCAR are thankfully acknowledged. NR 40 TC 2 Z9 2 U1 8 U2 8 PU SPRINGER BASEL AG PI BASEL PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND SN 0033-4553 EI 1420-9136 J9 PURE APPL GEOPHYS JI Pure Appl. Geophys. PD SEP PY 2016 VL 173 IS 9 BP 2983 EP 3010 DI 10.1007/s00024-016-1374-0 PG 28 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA DV5BU UT WOS:000382941400002 ER PT J AU Hang, C Nadeau, DF Gultepe, I Hoch, SW Roman-Cascon, C Pryor, K Fernando, HJS Creegan, ED Leo, LS Silver, Z Pardyjak, ER AF Hang, C. Nadeau, D. F. Gultepe, I. Hoch, S. W. Roman-Cascon, C. Pryor, K. Fernando, H. J. S. Creegan, E. D. Leo, L. S. Silver, Z. Pardyjak, E. R. TI A Case Study of the Mechanisms Modulating the Evolution of Valley Fog SO PURE AND APPLIED GEOPHYSICS LA English DT Article DE Ice fog; internal gravity wave; mountain complex terrain; radiation fog; turbulence-wave interaction ID QUASI-PERIODIC OSCILLATIONS; NOCTURNAL BOUNDARY-LAYER; RADIATION-FOG; GRAVITY-WAVES; ARCTIC CLOUDS; TURBULENCE; FIELD; CALIFORNIA; PREDICTION; EPISODES AB We present a valley fog case study in which radiation fog is modulated by topographic effects using data obtained from a field campaign conducted in Heber Valley, Utah from January 7-February 1, 2015, as part of the Mountain Terrain Atmospheric Modeling and Observations (MATERHORN) program. We use data collected on January 9, 2015 to gain insight into relationships between typical shallow radiation fog, turbulence, and gravity waves associated with the surrounding topography. A ae 10-30 m fog layer formed by radiative cooling was observed from 0720 to 0900 MST under cold air temperatures (aea'9 A degrees C), near-saturated (relative humidity with respect to water ae95 %), and calm wind (mostly < 0.5 m s(-1)) conditions. Drainage flows were observed occasionally prior to fog formation, which modulated heat exchanges between air masses through the action of internal gravity waves and cold-air pool sloshing. The fog appeared to be triggered by cold-air advection from the south (ae200A degrees) at 0700 MST. Quasi-periodic oscillations were observed before and during the fog event with a time period of about 15 min. These oscillations were detected in surface pressure, temperature, sensible heat flux, incoming longwave radiation, and turbulent kinetic energy measurements. We hypothesize that the quasi-periodic oscillations were caused by atmospheric gravity waves with a time period of about 10-20 min based on wavelet analysis. During the fog event, internal gravity waves led to about 1 A degrees C fluctuations in air temperatures. After 0835 MST when net radiation became positive, fog started to dissipate due to the surface heating and heat absorption by the fog particles. Overall, this case study provides a concrete example of how fog evolution is modulated by very weak thermal circulations in mountainous terrain and illustrates the need for high density vertical and horizontal measurements to ensure that the highly spatially varying physics in complex terrain are sufficient for hypothesis testing. C1 [Hang, C.; Pardyjak, E. R.] Univ Utah, Dept Mech Engn, Salt Lake City, UT 84112 USA. [Nadeau, D. F.] Univ Laval, Dept Civil & Water Engn, Quebec City, PQ, Canada. [Gultepe, I.] Environm Canada, Cloud Phys & Severe Weather Res Sect, Toronto, ON, Canada. [Hoch, S. W.] Univ Utah, Dept Atmospher Sci, Salt Lake City, UT USA. [Roman-Cascon, C.] Univ Complutense Madrid, Dept Geofis & Meteorol, Madrid, Spain. [Pryor, K.] NOAA, Natl Environm Satellite Data & Informat Serv, Ctr Satellite Applicat & Res, Camp Springs, MD USA. [Fernando, H. J. S.; Leo, L. S.; Silver, Z.] Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, Notre Dame, IN 46556 USA. [Fernando, H. J. S.] Univ Notre Dame, Dept Aerosp & Mech Engn, Notre Dame, IN 46556 USA. [Creegan, E. D.] Army Res Lab, Battlefield Environm Div, White Sands Missile Range, NM USA. RP Pardyjak, ER (reprint author), Univ Utah, Dept Mech Engn, Salt Lake City, UT 84112 USA. EM pardyjak@eng.utah.edu RI Pryor, Ken/F-5620-2010; Leo, Laura/J-9529-2013 OI Pryor, Ken/0000-0002-9766-2080; Leo, Laura/0000-0003-4103-6862 FU Office of Naval Research [N00014-11-1-0709] FX This research was funded by the Office of Naval Research Award #N00014-11-1-0709, Mountain Terrain Atmospheric Modeling and Observations (MATERHORN) Program. We are grateful the John Pace and Dragan Zajic from the U.S. Army Dugway Proving grounds for their gracious help and instrument contributions to the project. The authors want to thank Stephan de Wekker for providing data from the automatic weather station. We would also like to thank Alexei Perelet, Derek Jensen, and Matt Jeglum for their help in the field. We are also extremely grateful to Grant Kohler and the Kohler family for the use of their farm during the experiment as well as all of the additional help that they regularly provided during the experiment. The authors are extremely grateful for all of the help during the field campaign, and the scientific insight provided by the MATERHORN team. NR 66 TC 1 Z9 1 U1 9 U2 9 PU SPRINGER BASEL AG PI BASEL PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND SN 0033-4553 EI 1420-9136 J9 PURE APPL GEOPHYS JI Pure Appl. Geophys. PD SEP PY 2016 VL 173 IS 9 BP 3011 EP 3030 DI 10.1007/s00024-016-1370-4 PG 20 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA DV5BU UT WOS:000382941400003 ER PT J AU Camacho, M Song, SA Tolisano, AM AF Camacho, Macario Song, Sungjin A. Tolisano, Anthony M. TI Oral pressure therapy (winx) for obstructive sleep apnea: a meta-analysis updating the systematic review SO SLEEP AND BREATHING LA English DT Letter C1 [Camacho, Macario; Song, Sungjin A.; Tolisano, Anthony M.] Tripler Army Med Ctr, Div Otolaryngol Sleep Surg & Sleep Med, 1 Jarrett White Rd, Honolulu, HI 96859 USA. RP Camacho, M (reprint author), Tripler Army Med Ctr, Div Otolaryngol Sleep Surg & Sleep Med, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM drcamachoent@yahoo.com NR 5 TC 0 Z9 0 U1 2 U2 2 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1520-9512 EI 1522-1709 J9 SLEEP BREATH JI Sleep Breath. PD SEP PY 2016 VL 20 IS 3 BP 1011 EP 1012 DI 10.1007/s11325-016-1350-z PG 2 WC Clinical Neurology; Respiratory System SC Neurosciences & Neurology; Respiratory System GA DV7XY UT WOS:000383153000015 PM 27122362 ER PT J AU Weinberg, R Freysinger, V Mellano, K Brookhouse, E AF Weinberg, Robert Freysinger, Valeria Mellano, Kathleen Brookhouse, Elizabeth TI Building Mental Toughness: Perceptions of Sport Psychologists SO SPORT PSYCHOLOGIST LA English DT Article ID AUSTRALIAN FOOTBALL; TRAINING-PROGRAM; PERFORMERS; COACHES; SOCCER AB Most of the data obtained in studying mental toughness has come from athletes, coaches, and sometimes parents. The purpose of the present investigation was to explore sport psychologists' experiences of building mental toughness and their perceptions of how coaches can build mental toughness in their athletes. A phenomenological approach to qualitative research guided the study. Semistructured qualitative interviews with 15 sport psychologists were conducted. A concept map was developed that illustrates the theme and subthemes that emerged from analysis of the interviews. As indicated, sport psychologists felt that coaches could build mental toughness in their athletes by behaving mindfully, which included putting athletes under adverse situations and providing (teaching) them with the mental skills to effectively cope with these adversities. These results both confirm and extend existing research on how to build mental toughness. C1 [Weinberg, Robert; Freysinger, Valeria; Mellano, Kathleen; Brookhouse, Elizabeth] Miami Univ, Dept Kinesiol & Hlth, Oxford, OH 45056 USA. [Mellano, Kathleen] Michigan State Univ, Dept Kinesiol, E Lansing, MI 48824 USA. [Brookhouse, Elizabeth] US Army, CSF Program 2, Ft Polk, LA USA. RP Weinberg, R (reprint author), Miami Univ, Dept Kinesiol & Hlth, Oxford, OH 45056 USA. EM weinber@miamioh.edu NR 37 TC 0 Z9 0 U1 25 U2 25 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 0888-4781 EI 1543-2793 J9 SPORT PSYCHOL JI Sport Psychol. PD SEP PY 2016 VL 30 IS 3 BP 231 EP 241 DI 10.1123/tsp.2015-0090 PG 11 WC Hospitality, Leisure, Sport & Tourism; Psychology, Applied; Psychology; Sport Sciences SC Social Sciences - Other Topics; Psychology; Sport Sciences GA DU3YE UT WOS:000382147700003 ER PT J AU Cheuvront, SN Munoz, CX Kenefick, RW AF Cheuvront, Samuel N. Munoz, Colleen X. Kenefick, Robert W. TI The void in using urine concentration to assess population fluid intake adequacy or hydration status SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article DE dehydration; fluid needs; hydration assessment; hypo-hydration; hypovolemia ID ARGININE-VASOPRESSIN; BIOLOGICAL VARIATION; PLASMA VASOPRESSIN; DEHYDRATION; WATER; OSMOLALITY; HUMANS; EXCRETION; ACCURACY; INDEXES AB Urine concentration can be used to assess fluid intake adequacy or to diagnose dehydration. However, too often urine concentration is used inappropriately to draw dubious conclusions that could have harmful health and economic consequences. Inappropriate uses of urine concentration relate primarily to convenience sampling (timing) and problems related to convenience sampling (misapplication of thresholds), but a conceptual problem also exists with using urine concentration in isolation. The purpose of this Perspective article is to briefly explain the problematic nature of current practices and to offer a possible solution to improve practice with minimal added complication. When urine is used exclusively to assess fluid intake adequacy and hydration status in adults, we propose that only when urine concentration is high (>850 mmol/kg) and urine excretion rate is low (<850 mL/24 h) should suspicion of inadequate drinking or impending dehydration be considered. Prospective tests of the 850 X 850 thresholds will provide supporting evidence and/or help refine the best thresholds for men and women, young and old. C1 [Cheuvront, Samuel N.; Kenefick, Robert W.] US Army Res Inst Environm Med, Natick, MA 01760 USA. [Munoz, Colleen X.] Univ Hartford, Hartford, CT USA. RP Cheuvront, SN (reprint author), US Army Res Inst Environm Med, Natick, MA 01760 USA. EM samuel.n.cheuvront.civ@mail.mil FU US Army Medical Research and Materiel Command FX Supported by US Army Medical Research and Materiel Command. NR 42 TC 0 Z9 0 U1 5 U2 5 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0002-9165 EI 1938-3207 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD SEP PY 2016 VL 104 IS 3 BP 553 EP 556 DI 10.3945/ajcn.115.129858 PG 4 WC Nutrition & Dietetics SC Nutrition & Dietetics GA DU7UU UT WOS:000382420900005 PM 27465376 ER PT J AU Berryman, CE Agarwal, S Lieberman, HR Fulgoni, VL Pasiakos, SM AF Berryman, Claire E. Agarwal, Sanjiv Lieberman, Harris R. Fulgoni, Victor L., III Pasiakos, Stefan M. TI Diets higher in animal and plant protein are associated with lower adiposity and do not impair kidney function in US adults SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article DE higher-protein diet; kidney function; cardiometabolic risk; NHANES; protein source; central adiposity ID PROCESSED MEAT CONSUMPTION; DOSE-RESPONSE METAANALYSIS; RED MEAT; PROSPECTIVE COHORT; FISH CONSUMPTION; HEART-DISEASE; ALL-CAUSE; RISK; MORTALITY; STROKE AB Background: Higher-protein diets are associated with decreased adiposity and greater HDL cholesterol than lower protein diets. Whether these benefits can be attributed to a specific protein source (i.e., non-dairy animal, dairy, or plant) is unknown, and concerns remain regarding the impact of higher-protein diets on kidney function. Objective: The objective of this study was to evaluate trends of protein source on markers of cardiometabolic disease risk and kidney function in US adults. Design: Total, nondairy animal, dairy, and plant protein intake were estimated with the use of 24-h recall data from NHANES 2007-2010 (n = 11,111; >= 19 y). Associations between source-specific protein intake and health outcomes were determined with the use of models that adjusted for sex, race and ethnicity, age, physical activity, poverty to-income ratio, individual intake (grams per kilogram) for each of the other 2 protein sources, body mass index (BMI) (except for weight related variables), and macronutrient (carbohydrate, fiber, and total and saturated fat) intake. Results: Mean +/- SE total protein intake was 82.3 +/- 0.8 g/d (animal. 37.4 +/- 0.5 g/d; plant: 24.7 +/- 0.3 g/d; and dairy: 13.4 +/- 0.3 g/d). Both BMI and waist circumference were inversely associated [regression coefficient (95% CI)] with animal [-0.199 (-0.265, -0.134), P < 0.0001; -0.505 (-0.641, -0.370), P < 0.0001] and plant [-0.346 (-0.455, -0.237), P < 0.0001; -0.826 (-1.114, -0.538), P < 0.0001] protein intake. Blood urea nitrogen concentrations increased across deciles for animal [0.313 (0.248, 0.379), P < 0.0001; decile 1-10: 11.6 +/- 0.2 to 14.9 +/- 0.3 mg/dL] and dairy [0.195 (0.139, 0.251), P < 0.0001; decile 1-10: 12.7 +/- 0.2 to 13.9 +/- 0.2 mg/dL] but not plant protein intake. Glomerular filtration rate and blood creatinine were not associated with intake of any protein source. Conclusions: Diets higher in plant and animal protein, independent of other dietary factors, are associated with cardiometabolic benefits, particularly improved central adiposity, with no apparent impairment of kidney function. C1 [Berryman, Claire E.; Lieberman, Harris R.; Pasiakos, Stefan M.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. [Berryman, Claire E.; Agarwal, Sanjiv] Oak Ridge Inst Sci & Educ, Belcamp, MD USA. [Fulgoni, Victor L., III] Henry M Jackson Fdn, Bethesda, MD USA. RP Pasiakos, SM (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. EM stefan.m.pasiakos.civ@mail.mil RI Pasiakos, Stefan/E-6295-2014; Berryman, Claire/B-5553-2017 OI Pasiakos, Stefan/0000-0002-5378-5820; FU US Army Military Research and Material Command; Department of Defense Center Alliance for Nutrition and Dietary Supplements Research FX Supported by the US Army Military Research and Material Command and the Department of Defense Center Alliance for Nutrition and Dietary Supplements Research. NR 43 TC 1 Z9 1 U1 11 U2 12 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0002-9165 EI 1938-3207 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD SEP PY 2016 VL 104 IS 3 BP 743 EP 749 DI 10.3945/ajcn.116.133819 PG 7 WC Nutrition & Dietetics SC Nutrition & Dietetics GA DU7UU UT WOS:000382420900027 PM 27465374 ER PT J AU Paul, SS Lester, ME Foreman, KB Dibble, LE AF Paul, S. S. Lester, M. E. Foreman, K. B. Dibble, L. E. TI Validity and Reliability of Two-Dimensional Motion Analysis for Quantifying Postural Deficits in Adults With and Without Neurological Impairment SO ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY LA English DT Article DE video analysis; validity; reliability; balance; motion analysis ID SIT-TO-STAND; PARKINSONS-DISEASE; BALANCE; PEOPLE; REHABILITATION; VARIABILITY; STABILITY; SYSTEMS; FALLS AB Frequently, clinical balance outcome measures are limited by floor or ceiling effects and provide insufficient resolution to determine subtle deficits. Detailed assessment of postural control obtained through posturography may be cost-prohibitive or logistically infeasible in some clinical settings. Two-dimensional (2D) motion analysis may provide a clinically feasible means of obtaining detailed quantification of balance deficits. Forty-five participants aged 18-80 years, with and without Parkinson disease, performed the Push and Release (PR) test, sit-to-stand (STS), and timed single leg stance (SLS). Performance was captured simultaneously using a three-dimensional (3D) (10-camera laboratory-based 3D motion capture system and 3D motion analysis software) and 2D (two commercially available video cameras and 2D motion analysis software) system. Agreement was excellent between 2D and 3D systems for all outcomes of the PR and SLS (intraclass correlation coefficients [ICC2,1] 0.96-0.99, 95% CIs 0.92-0.98 to 0.99-1.0), and ranged from fair to excellent for STS outcomes (ICC2,1 0.59-0.93, 95% CIs 0.36-0.75 to 0.87-0.96). Test-retest reliability (ICC3,1 0.89-1.0, 95% CIs 0.76-0.96 to 1.0-1.0) and inter-rater reliability (ICC2,1 0.77-1.0, 95% CIs 0.61-0.87 to 1.0-1.0) of the 2D obtained outcomes were excellent. A technology package of commonly available video cameras and 2D motion analysis software was a valid and reliable method for quantifying outcomes of postural control tasks in people with a range of balance abilities. Two-dimensional analysis can be used in clinical practice to provide balance assessments as a cost-effective alternative to 3D motion capture. Anat Rec, 299:1165-1173, 2016. (c) 2016 Wiley Periodicals, Inc. C1 [Paul, S. S.; Foreman, K. B.; Dibble, L. E.] Univ Utah, Dept Phys Therapy, 520 Wakara Way, Salt Lake City, UT 84108 USA. [Paul, S. S.] Univ Sydney, George Inst Global Hlth, Sydney Med Sch, Camperdown, NSW 2050, Australia. [Lester, M. E.] US Army Baylor Univ, Doctoral Program Phys Therapy, Joint Base San Antonio F, TX 78234 USA. RP Dibble, LE (reprint author), Univ Utah, Dept Phys Therapy, 520 Wakara Way, Salt Lake City, UT 84108 USA. EM lee.dibble@hsc.utah.edu FU USA Army Advanced Medical Technology Initiative FX Grant sponsor: USA Army Advanced Medical Technology Initiative; Grant number: N/A. NR 28 TC 0 Z9 0 U1 2 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1932-8486 EI 1932-8494 J9 ANAT REC JI Anat. Rec. PD SEP PY 2016 VL 299 IS 9 BP 1165 EP 1173 DI 10.1002/ar.23385 PG 9 WC Anatomy & Morphology SC Anatomy & Morphology GA DV1TI UT WOS:000382703600002 PM 27314922 ER PT J AU Chang, TW Janardhanan, P Mello, CM Singh, BR Cai, SW AF Chang, Tzuu-Wang Janardhanan, Pavithra Mello, Charlene M. Singh, Bal Ram Cai, Shuowei TI Selection of RNA Aptamers Against Botulinum Neurotoxin Type A Light Chain Through a Non-Radioactive Approach SO APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY LA English DT Article DE RNA; Aptamer; 2 '-fluorine-pyrimidine; Surface plasmon resonance; Botulinum neurotoxin; Antidote; Endopeptidase ID SURFACE-PLASMON RESONANCE; CLOSTRIDIUM-BOTULINUM; RECOGNITION; STRATEGIES; TOXIN; CELLS AB Botulinum neurotoxin (BoNT), a category A agent, is the most toxic molecule known to mankind. The endopeptidase activity of light chain domain of BoNT is the cause for the inhibition of the neurotransmitter release and the flaccid paralysis that leads to lethality in botulism. Currently, antidotes are not available to reverse the flaccid paralysis caused by BoNT. In the present study, a non-radioactive-based systematic evolution of ligands by exponential enrichment (SELEX) process is developed by utilizing surface plasmon resonance to monitor the binding enrichment. Two RNA aptamers have been identified as strong binders against light chain of botulinum neurotoxin type A. These two aptamers showed strong inhibition activity on LCA, with IC50 in nanomolar range. Inhibition kinetic studies reveal mid nanomolar K-I and non-competitive nature of their inhibition, suggesting that they have strong potential as antidotes that can reverse the symptom caused by BoNT/A. More importantly, we observed that the 2'-fluorine-pyrimidine-modified RNA aptamers identified here do not change their binding and biological activities. This observation could lead to a cost-effective way for SELEX, by using regular nucleotide during SELEX, and 2'-fluorine-pyrimidine-modified nucleotide for final application to enhance their RNase-resistance. C1 [Chang, Tzuu-Wang; Janardhanan, Pavithra; Cai, Shuowei] Univ Massachusetts Dartmouth, Dept Chem & Biochem, 285 Old Westport Rd, N Dartmouth, MA 02747 USA. [Mello, Charlene M.] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. [Singh, Bal Ram] Botulinum Res Ctr, Inst Adv Sci, Dartmouth, MA 02747 USA. RP Cai, SW (reprint author), Univ Massachusetts Dartmouth, Dept Chem & Biochem, 285 Old Westport Rd, N Dartmouth, MA 02747 USA. EM scai@umassd.edu FU NIH [1R21AI070787-01A2]; US Army Natick Soldier Center grant [W911QY-09-C-0207] FX This project is partially funded by an NIH grant (1R21AI070787-01A2) and US Army Natick Soldier Center grant (W911QY-09-C-0207). Authors would like to sincerely thank Drs. Ravi Singh and Natalia Singh from Iowa State University for their help on the design of the library and the SELEX process. NR 33 TC 0 Z9 0 U1 12 U2 12 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA SN 0273-2289 EI 1559-0291 J9 APPL BIOCHEM BIOTECH JI Appl. Biochem. Biotechnol. PD SEP PY 2016 VL 180 IS 1 BP 10 EP 25 DI 10.1007/s12010-016-2081-0 PG 16 WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology GA DV1IU UT WOS:000382675300003 PM 27085355 ER PT J AU Dobson, NR Liu, XX Rhein, LM Darnall, RA Corwin, MJ McEntire, BL Ward, RM James, LP Sherwin, CMT Heeren, TC Hunt, CE AF Dobson, Nicole R. Liu, Xiaoxi Rhein, Lawrence M. Darnall, Robert A. Corwin, Michael J. McEntire, Betty L. Ward, Robert M. James, Laura P. Sherwin, Catherine M. T. Heeren, Timothy C. Hunt, Carl E. TI Salivary caffeine concentrations are comparable to plasma concentrations in preterm infants receiving extended caffeine therapy SO BRITISH JOURNAL OF CLINICAL PHARMACOLOGY LA English DT Article DE caffeine; pharmacokinetic model; preterm infant; saliva ID PREMATURE-INFANTS; POPULATION PHARMACOKINETICS; INTRAVENOUS CAFFEINE; DRUG CONCENTRATION; SERUM CAFFEINE; APNEA; MILK; METHYLXANTHINES; THEOPHYLLINE; TRIAL AB AimsCaffeine concentrations in preterm infants are usually measured in the blood. However, salivary assays may provide a valid and practical alternative. The present study explored the validity and clinical utility of salivary caffeine concentrations as an alternative to blood concentrations and developed a novel plasma/salivary caffeine distribution model. MethodsPaired salivary and plasma samples were obtained in 29 infants. Salivary samples were obtained using a commercially available salivary collection system. Caffeine concentrations in the saliva and plasma were determined using high-performance liquid chromatography. A population pharmacokinetic (PK) model was developed using NONMEM 7.3. ResultsThe mean ( standard deviation) gestational age (GA) at birth and birth weight were 27.9 +/- 2.1weeks and 1171.6 +/- 384.9g, respectively. Paired samples were obtained at a mean postmenstrual age (PMA) of 35.5 +/- 1.1weeks. The range of plasma caffeine concentrations was 9.5-54.1gml(-1), with a mean difference (95% confidence interval) between plasma and salivary concentrations of -0.18gml(-1) (-1.90, 1.54). Salivary and plasma caffeine concentrations were strongly correlated (Pearson's correlation coefficient=0.87, P<0.001). Caffeine PK in plasma and saliva was simultaneously described by a three-compartment recirculation model. Current body weight, birth weight, GA, PMA and postnatal age were not significantly correlated with any PK parameter. ConclusionsSalivary sampling provides an easy, non-invasive method for measuring caffeine concentrations. Salivary concentrations correlate highly with plasma concentrations. Caffeine PK in saliva and plasma are well described by a three-compartment recirculation model. C1 [Dobson, Nicole R.] Tripler Army Med Ctr, Pediat, Honolulu, HI 96859 USA. [Liu, Xiaoxi; Ward, Robert M.; Sherwin, Catherine M. T.] Univ Utah, Sch Med, Clin Pharmacol, Pediat, Salt Lake City, UT USA. [Rhein, Lawrence M.] Boston Childrens Hosp, Newborn Med & Resp Dis, Boston, MA USA. [Darnall, Robert A.] Geisel Sch Med Dartmouth, Lebanon, NH USA. [Corwin, Michael J.] Boston Univ, Slone Epidemiol Ctr, Boston, MA 02215 USA. [McEntire, Betty L.] Amer SIDS Inst, Naples, FL USA. [James, Laura P.] Univ Arkansas, Pediat, Little Rock, AR 72204 USA. [Heeren, Timothy C.] Boston Univ, Sch Publ Hlth, Biostat, Boston, MA USA. [Hunt, Carl E.] Uniformed Serv Univ Hlth Sci, Pediat, Bethesda, MD USA. [Hunt, Carl E.] George Washington Univ, Pediat, Washington, DC USA. RP Dobson, NR (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM nicole.r.dobson.mil@mail.mil FU American SIDS Institute FX The authors would like to thank Lynda Letzig for her work in optimizing the high-performance liquid chromatography caffeine analysis and Denis Rybin, PhD, MS, for his contributions to study conduct and data analysis. This study was funded by the American SIDS Institute. Oximeter equipment was provided by Masimo, Irvine, CA, USA. Recording equipment was provided by Acumen Instruments Corporation, Ames, IA, USA. NR 31 TC 0 Z9 0 U1 4 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0306-5251 EI 1365-2125 J9 BRIT J CLIN PHARMACO JI Br. J. Clin. Pharmacol. PD SEP PY 2016 VL 82 IS 3 BP 754 EP 761 DI 10.1111/bcp.13001 PG 8 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA DU9AZ UT WOS:000382509900014 PM 27145974 ER PT J AU Martins, KA Jahrling, PB Bavari, S Kuhn, JH AF Martins, Karen A. Jahrling, Peter B. Bavari, Sina Kuhn, Jens H. TI Ebola virus disease candidate vaccines under evaluation in clinical trials SO EXPERT REVIEW OF VACCINES LA English DT Review DE Candidate vaccine; clinical trial; Ebola virus; Ebola virus disease; ebolavirus; EBOV; EVD; Filoviridae; filovirus; MCM; medical countermeasure; vaccine ID VESICULAR-STOMATITIS-VIRUS; ADENOVIRUS-BASED VACCINE; T-CELL RESPONSES; PROTECTS NONHUMAN-PRIMATES; FILOVIRUS-LIKE PARTICLES; IMMUNE-RESPONSES; PREEXISTING IMMUNITY; MARBURG VIRUSES; DOUBLE-BLIND; NEUTRALIZING ANTIBODIES AB Filoviruses are the etiological agents of two human illnesses: Ebola virus disease and Marburg virus disease. Until 2013, medical countermeasure development against these afflictions was limited to only a few research institutes worldwide as both infections were considered exotic due to very low case numbers. Together with the high case-fatality rate of both diseases, evaluation of any candidate countermeasure in properly controlled clinical trials seemed impossible. However, in 2013, Ebola virus was identified as the etiological agent of a large disease outbreak in Western Africa including almost 30,000 infections and more than 11,000 deaths, including case exportations to Europe and North America. These large case numbers resulted in medical countermeasure development against Ebola virus disease becoming a global public-health priority. This review summarizes the status quo of candidate vaccines against Ebola virus disease, with a focus on those that are currently under evaluation in clinical trials. C1 [Martins, Karen A.; Bavari, Sina] US Army Med Res Inst Infect Dis, Frederick, MD USA. [Jahrling, Peter B.; Kuhn, Jens H.] NIAID, Integrated Res Facil Ft Detrick, Div Clin Res, NIH, Frederick, MD 21702 USA. RP Kuhn, JH (reprint author), NIAID, Integrated Res Facil Ft Detrick IRF Frederick, Div Clin Res, NIH, B-8200 Res Plaza, Frederick, MD 21702 USA. EM kuhnjens@mail.nih.gov FU NIAID [HHSN272200700016I] FX We thank Laura Bollinger (Integrated Research Facility at Fort Detrick) for providing Technical Writing Services in critically editing this manuscript on behalf of Battelle Memorial Institute through Battelle Memorial Institute's prime contract with NIAID under Contract No. HHSN272200700016I. NR 105 TC 5 Z9 5 U1 24 U2 24 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 1476-0584 EI 1744-8395 J9 EXPERT REV VACCINES JI Expert Rev. Vaccines PD SEP PY 2016 VL 15 IS 9 SI SI BP 1101 EP 1112 DI 10.1080/14760584.2016.1187566 PG 12 WC Immunology SC Immunology GA DV2TX UT WOS:000382775700006 PM 27160784 ER PT J AU Head, JR Tenan, MS Tweedell, AJ Price, TF LaFiandra, ME Helton, WS AF Head, James R. Tenan, Matthew S. Tweedell, Andrew J. Price, Thomas F. LaFiandra, Michael E. Helton, William S. TI Cognitive Fatigue Influences Time-On-Task during Bodyweight Resistance Training Exercise SO FRONTIERS IN PHYSIOLOGY LA English DT Article DE cognitive fatigue; bodyweight resistance training exercise; mental workload ID MENTAL FATIGUE; PERFORMANCE; IMPACT; INTENSITY; VIGILANCE; STIMULI; WORK AB Prior investigations have shown measurable performance impairments on continuous physical performance tasks when preceded by a cognitively fatiguing task. However, the effect of cognitive fatigue on bodyweight resistance training exercise task performance is unknown. In the current investigation 18 amateur athletes completed a full body exercise task preceded by either a cognitive fatiguing or control intervention. In a randomized repeated measure design, each participant completed the same exercise task preceded by a 52 min cognitively fatiguing intervention (vigilance) or control intervention (video). Data collection sessions were separated by 1 week. Participants rated the fatigue intervention with a significantly higher workload compared to the control intervention (p < 0.001). Additionally, participants self-reported significantly greater energetic arousal for cognitively fatiguing task (p = 0.02). Cognitive fatigue did not significantly impact number of repetitions completed during the exercise task (p = 0.77); however, when cognitively fatigued, participants had decreased percent time-on-task (57%) relative to the no fatigue condition (60%; p = 0.04). RPE significantly changed over time (p < 0.001), but failed to show significant differences between the cognitive fatigue intervention and control intervention (p > 0.05). There was no statistical difference for heart rate or metabolic expenditure as a function of fatigue intervention during exercise. Cognitively fatigued athletes have decreased time-on-task in bodyweight resistance training exercise tasks. C1 [Head, James R.; Tenan, Matthew S.; Tweedell, Andrew J.; Price, Thomas F.; LaFiandra, Michael E.] US Army, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. [Helton, William S.] George Mason Univ, Dept Psychol, Fairfax, VA 22030 USA. RP Head, JR (reprint author), US Army, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. EM james.r.head27.ctr@mail.mil NR 46 TC 0 Z9 0 U1 10 U2 10 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1664-042X J9 FRONT PHYSIOL JI Front. Physiol. PD SEP 1 PY 2016 VL 7 AR 373 DI 10.3389/fphys.2016.00373 PG 10 WC Physiology SC Physiology GA DU6DY UT WOS:000382305300001 PM 27635122 ER PT J AU Niu, N Jin, XY Niu, ZD Cheng, JRC Li, L Kataev, MY AF Niu, Nan Jin, Xiaoyu Niu, Zhendong Cheng, Jing-Ru C. Li, Ling Kataev, Mikhail Yu TI A Clustering-Based Approach to Enriching Code Foraging Environment SO IEEE TRANSACTIONS ON CYBERNETICS LA English DT Article DE Code navigation; cybernetic enrichment; foraging theory; information seeking; program investigation; software clustering ID SOFTWARE; INFORMATION; SUPPORT; MODEL; OPTIMIZATION; ALGORITHM; FRAMEWORK; SYSTEMS AB Developers often spend valuable time navigating and seeking relevant code in software maintenance. Currently, there is a lack of theoretical foundations to guide tool design and evaluation to best shape the code base to developers. This paper contributes a unified code navigation theory in light of the optimal food-foraging principles. We further develop a novel framework for automatically assessing the foraging mechanisms in the context of program investigation. We use the framework to examine to what extent the clustering of software entities affects code foraging. Our quantitative analysis of long-lived open-source projects suggests that clustering enriches the software environment and improves foraging efficiency. Our qualitative inquiry reveals concrete insights into real developer's behavior. Our research opens the avenue toward building a new set of ecologically valid code navigation tools. C1 [Niu, Nan; Jin, Xiaoyu] Univ Cincinnati, Dept Elect Engn & Comp Syst, Cincinnati, OH 45221 USA. [Niu, Zhendong] Beijing Inst Technol, Sch Comp Sci & Technol, Beijing 100081, Peoples R China. [Cheng, Jing-Ru C.] US Army, Informat Technol Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Li, Ling] Old Dominion Univ, Dept Informat Technol & Decis Sci, Norfolk, VA 23529 USA. [Kataev, Mikhail Yu] Tomsk State Univ Control Syst & Radioelect, Dept Control Syst, Tomsk 634050, Russia. RP Niu, N (reprint author), Univ Cincinnati, Dept Elect Engn & Comp Syst, Cincinnati, OH 45221 USA. EM nan.niu@uc.edu FU U.S. National Science Foundation [CCF-1238336, CCF-1350487]; National Natural Science Foundation of China [61375053] FX This work was supported in part by the U.S. National Science Foundation under Grant CCF-1238336 and Grant CCF-1350487, and in part by the National Natural Science Foundation of China under Grant 61375053. NR 62 TC 0 Z9 0 U1 4 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 2168-2267 EI 2168-2275 J9 IEEE T CYBERNETICS JI IEEE T. Cybern. PD SEP PY 2016 VL 46 IS 9 BP 1962 EP 1973 DI 10.1109/TCYB.2015.2419811 PG 12 WC Computer Science, Artificial Intelligence; Computer Science, Cybernetics SC Computer Science GA DU4IH UT WOS:000382175800001 ER PT J AU Haile, MA Riddick, JC Assefa, AH AF Haile, Mulugeta A. Riddick, Jaret C. Assefa, Abey H. TI Robust Particle Filters for Fatigue Crack Growth Estimation in Rotorcraft Structures SO IEEE TRANSACTIONS ON RELIABILITY LA English DT Article DE Fatigue crack; NASGRO; Paris-Erdogan model; particle filters (PF); probability of detection (PoD); rotorcraft flight load; state-space model; structural health monitoring (SHM); ultrasonic ID PIEZOELECTRIC SENSOR/ACTUATOR NETWORK; WAFER ACTIVE SENSORS; DIAGNOSTICS; FRAMEWORK AB Fatigue crack growth propagation in critical rotorcraft structures is much more complex than fixed-wing aircrafts in part due to the random and vibratory nature of the rotorcraft flight load spectrum. Existing physical damage models, which are originally developed for the uniform cyclic loads of fixed-wing platforms, are not accurate enough for rotorcraft structures. Such inaccuracy often results in increased risk of operation and higher cost of maintenance. The goal of this paper is to present an integrated diagnostic framework for accurate fatigue life estimation of critical rotorcraft structures by combining the predictions of a physical damage model and evidence from real-time diagnostic sensor data. The diagnostic framework obtains the most probable crack size at each inspection interval using a sequential Monte Carlo method known as particle filters. To validate the framework, three representative rotorcraft principal structural elements were tested using an actual rotorcraft flight load spectrum. Results show that the crack size estimation error of the method presented here is much lower than any of the currently available physical damage models. C1 [Haile, Mulugeta A.] US Army, Vehicle Technol Directorate, Res Lab, Aberdeen, MD 21005 USA. [Riddick, Jaret C.] US Army, Air Portfolio Off, Res & Technol, ASSALT, Crystal City, VA 22202 USA. [Assefa, Abey H.] Univ Surrey, Dept Math, Guildford GU2 7XH, Surrey, England. RP Haile, MA (reprint author), US Army, Vehicle Technol Directorate, Res Lab, Aberdeen, MD 21005 USA. EM mulugeta.a.haile.civ@mail.mil; jaret.riddick.civ@mail.mil; abbeyatta@gmail.com NR 26 TC 0 Z9 0 U1 6 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9529 EI 1558-1721 J9 IEEE T RELIAB JI IEEE Trans. Reliab. PD SEP PY 2016 VL 65 IS 3 BP 1438 EP 1448 DI 10.1109/TR.2016.2590258 PG 11 WC Computer Science, Hardware & Architecture; Computer Science, Software Engineering; Engineering, Electrical & Electronic SC Computer Science; Engineering GA DV1XC UT WOS:000382714400026 ER PT J AU Zecevic, M Beyerlein, IJ McCabe, RJ McWilliams, BA Knezevic, M AF Zecevic, Miroslav Beyerlein, Irene J. McCabe, Rodney J. McWilliams, Brandon A. Knezevic, Marko TI Transitioning rate sensitivities across multiple length scales: Microstructure-property relationships in the Taylor cylinder impact test on zirconium SO INTERNATIONAL JOURNAL OF PLASTICITY LA English DT Article DE Microstructures; Elastic-viscoplastic material; Rate-dependent material; Impact testing; Finite elements ID X-RAY-DIFFRACTION; IMPLICIT FINITE-ELEMENTS; DUCTILE SINGLE-CRYSTALS; CRYSTALLOGRAPHIC TEXTURE EVOLUTION; POLYCRYSTALLINE HCP/BCC COMPOSITES; PRESSURE-DOUBLE-TORSION; FLAT-ENDED PROJECTILES; LINE-PROFILE ANALYSIS; STRAIN-PATH CHANGES; SELF-CONSISTENT AB A finite-element based plasticity model is developed for polycrystals deformed to high strain-rates. The model is multiscale, covering from thermally activated dislocation motion on a specific crystallographic slip system (nm), to single crystal plasticity (mu m), to polycrystalline aggregate plasticity (mm), and ultimately heterogeneous deformation of the macroscale test sample (m). Within the model, the rate dependence in macroscale response arises solely from the microscopic characteristic stress to activate dislocation motion. This is accomplished by introduction of a novel methodology, used at the intermediate length scales, to relax the extraneous rate dependencies occurring as a result of the visco-plastic rate sensitive flow rule commonly associated with single crystal plasticity formulations. The multi-scale model developed here also permits simulations to be carried out in stress imposed, strain-rate imposed, and mixed stress/strain-rate-imposed boundary conditions, another advancement over previous techniques. Simulation results are presented for the deformation of high-purity Zr in a Taylor impact cylinder test. The variation in sample shape changes, texture evolution, and deformation twin fraction after the test are experimentally examined. These same quantities are calculated with the model and good agreement is achieved in all aspects. We show that without adjustment of material parameters that the thermally activated hardening model applies to much higher strain-rates (104/s-105/s) than the strain-rates used previously to characterize it. This model can be broadly applied to understanding microstructure-property relationships in high-strain-rate deformation processes that generate spatially and temporarily heterogeneous mechanical fields. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Zecevic, Miroslav; Knezevic, Marko] Univ New Hampshire, Dept Mech Engn, 33 Acad Way,Kingsbury Hall,W119, Durham, NH 03824 USA. [Beyerlein, Irene J.] Los Alamos Natl Lab, Div Theoret, Los Alamos, NM 87545 USA. [McCabe, Rodney J.] Los Alamos Natl Lab, Mat Sci & Technol Div, Los Alamos, NM 87545 USA. [McWilliams, Brandon A.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Knezevic, M (reprint author), Univ New Hampshire, Dept Mech Engn, 33 Acad Way,Kingsbury Hall,W119, Durham, NH 03824 USA. EM marko.knezevic@unh.edu FU Army Research Laboratory; Los Alamos National Laboratory Directed Research and Development (LDRD) project [ER20140348]; [W911NF-15-2-0084] FX This research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-15-2-0084. IJB would like to acknowledge support through a Los Alamos National Laboratory Directed Research and Development (LDRD) project ER20140348. The authors would like to thank Dr. John F. Bingert for supplying the Taylor impact testing and characterization data sets. NR 96 TC 1 Z9 1 U1 2 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0749-6419 EI 1879-2154 J9 INT J PLASTICITY JI Int. J. Plast. PD SEP PY 2016 VL 84 BP 138 EP 159 DI 10.1016/j.ijplas.2016.05.005 PG 22 WC Engineering, Mechanical; Materials Science, Multidisciplinary; Mechanics SC Engineering; Materials Science; Mechanics GA DT5PG UT WOS:000381534500006 ER PT J AU Piccirillo, AL Packnett, ER Cowan, DN Boivin, MR AF Piccirillo, Amanda L. Packnett, Elizabeth R. Cowan, David N. Boivin, Michael R. TI Epidemiology of asthma-related disability in the US Armed Forces: 2007-2012 SO JOURNAL OF ASTHMA LA English DT Article DE Asthma; adult-onset; asthma; occupational; deployment; military; comorbidity; disability evaluation ID DEPLOYED MILITARY PERSONNEL; NEW-ONSET ASTHMA; MARINE CORPS; RISK-FACTORS; RESPIRATORY SYMPTOMS; WORK DISABILITY; LUNG-DISEASE; HEALTH; AFGHANISTAN; PREVALENCE AB Objective: To characterize the demographic, disability and deployment characteristics of U.S. Armed Forces personnel with an asthma-related disability discharge, which includes separation (without benefits) and retirement (with disability benefits). Methods: Incidence rates for personnel evaluated for disability discharge and/or disability retired due to asthma and due to all other causes of disability discharge were calculated per 100,000 active duty enlisted service members by year. Multivariate logistical regression was used to examine the associations between disability retirement and several demographic and disability characteristics of service members evaluated for asthma-related disability discharge versus those evaluated for any other non-respiratory condition for each branch of military service. Results: Service members evaluated for disability discharge related to asthma most often do not have comorbidity and are disability retired rather than separated, with rates of disability retirement increasing over time. Groups with a significantly higher incidence of evaluation for asthma-related disability include females, individuals who entered the military prior to the age of 20, non-Whites, and those with a history of deployment to Iraq or Afghanistan. The characteristic most associated with the odds of disability retirement was a history of deployment. Conclusions: New-onset asthma occurring after military entry often causes occupational impairment in service members, especially in those that have been deployed to Iraq or Afghanistan. C1 [Piccirillo, Amanda L.; Packnett, Elizabeth R.; Cowan, David N.; Boivin, Michael R.] Walter Reed Army Inst Res, Dept Epidemiol, Prevent Med Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. [Piccirillo, Amanda L.; Packnett, Elizabeth R.; Cowan, David N.] ManTech Int Corp, ManTech Hlth, Herndon, VA USA. RP Piccirillo, AL (reprint author), Walter Reed Army Inst Res, Dept Epidemiol, Prevent Med Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM amanda.l.piccirillo.ctr@mail.mil NR 39 TC 0 Z9 0 U1 2 U2 3 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 0277-0903 EI 1532-4303 J9 J ASTHMA JI J. Asthma PD SEP PY 2016 VL 53 IS 7 BP 668 EP 678 DI 10.3109/02770903.2016.1154070 PG 11 WC Allergy; Respiratory System SC Allergy; Respiratory System GA DT2GJ UT WOS:000381298500002 PM 27050635 ER PT J AU Lundy, JB Chung, KK Pamplin, JC Ainsworth, CR Jeng, JC Friedman, BC AF Lundy, Jonathan B. Chung, Kevin K. Pamplin, Jeremy C. Ainsworth, Craig R. Jeng, James C. Friedman, Bruce C. TI Update on Severe Burn Management for the Intensivist SO JOURNAL OF INTENSIVE CARE MEDICINE LA English DT Review DE critical care; shock; resuscitation; mechanical ventilation; sedation ID RESPIRATORY-DISTRESS-SYNDROME; ACUTE KIDNEY INJURY; FREQUENCY PERCUSSIVE VENTILATION; RESTING ENERGY-EXPENDITURE; BLOOD-STREAM INFECTIONS; INHALATION INJURY; SMOKE-INHALATION; CARBON-MONOXIDE; METHYLENE-BLUE; SEPTIC SHOCK AB Thermal injury of humans causes arguably the most severe perturbations in physiology that can be experienced. These physiologic derangements start immediately and can persist in some form until months or even years after the burn wounds are healed. Burn shock, marked activation of the systemic inflammatory response, multiple-organ failure, infection, and wound failure are just a few of the insults that may require management by the intensivist. The purpose of this article is to review recent advances in the critical care management of thermally injured patients. C1 [Lundy, Jonathan B.; Chung, Kevin K.; Pamplin, Jeremy C.] US Army Inst Surg Res, Burn Ctr, 3698 Chambers Pass,STE B, Ft Sam Houston, TX 78234 USA. [Lundy, Jonathan B.; Chung, Kevin K.; Pamplin, Jeremy C.] Uniformed Serv Univ Hlth Sci, Dept Med, Room A3060, Bethesda, MD 20814 USA. [Ainsworth, Craig R.] William Beaumont Army Med Ctr, Dept Med, Ft Bliss, TX USA. [Jeng, James C.] Mt Sinai Beth Israel Med Ctr, Dept Surg, New York, NY USA. [Friedman, Bruce C.] Joseph M Still Burn Ctr, Augusta, GA USA. RP Chung, KK (reprint author), US Army Inst Surg Res, Burn Ctr, 3698 Chambers Pass,STE B, Ft Sam Houston, TX 78234 USA. EM kevin.k.chung.mil@mail.mil NR 103 TC 0 Z9 0 U1 9 U2 9 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0885-0666 EI 1525-1489 J9 J INTENSIVE CARE MED JI J. Intensive Care Med. PD SEP PY 2016 VL 31 IS 8 BP 499 EP 510 DI 10.1177/0885066615592346 PG 12 WC Critical Care Medicine SC General & Internal Medicine GA DV0DT UT WOS:000382588900002 PM 26112758 ER PT J AU Knapik, JJ Trone, DW Austin, KG Steelman, RA Farina, EK Lieberman, HR AF Knapik, Joseph J. Trone, Daniel W. Austin, Krista G. Steelman, Ryan A. Farina, Emily K. Lieberman, Harris R. TI Prevalence, Adverse Events, and Factors Associated with Dietary Supplement and Nutritional Supplement Use by US Navy and Marine Corps Personnel SO JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS LA English DT Article DE Vitamin; Mineral; Prohormone; Sport drinks; Sport bars/gels ID ACUTE LIVER-INJURY; WEIGHT-LOSS; UNITED-STATES; GENDER-DIFFERENCES; NATIONAL-HEALTH; NO-XPLODE; CARE UTILIZATION; ACUTE HEPATITIS; OXYELITE PRO; HYDROXYCUT AB Background About 50% of Americans and 60% to 70% of US military personnel use dietary supplements, some of which have been associated with adverse events (AEs). Nutritional supplements like sport drinks and sport bars/gels are also commonly used by athletes and service members. Previous dietary supplement and nutritional supplement surveys were conducted on Army, Air Force, and Coast Guard personnel. Objective The aim of this cross-sectional study was to investigate dietary and nutritional supplement use in Navy and Marine Corps personnel, including the prevalence, types, factors associated with use, and AEs. Design A random sample of 10,000 Navy and Marine Corps personnel were contacted. Service members were asked to complete a detailed questionnaire describing their personal characteristics, supplement use, and AEs experienced. Results In total, 1,708 service members completed the questionnaire during August through December 2014, with 1,683 used for analysis. Overall, 73% reported using dietary supplements one or more times per week. The most commonly used dietary supplements (used one or more times per week) were multivitamins/multiminerals (48%), protein/amino acids (34%), combination products (33%), and individual vitamins and minerals (29%). About 31% of service members reported using five or more dietary supplements. Sport drinks and sport bars/gels were used by 45% and 23% of service members, respectively. Monthly expenditures on dietary supplements averaged $39; 31% of service members spent >=$50/mo. Multivariate logistic regression modeling indicated that female sex (women/men; odds ratio [OR]=1.76, 95% CI 1.32 to 2.36), higher educational level (college degree/no college degree; OR=2.23, 95% CI 1.62 to 3.30), higher body mass index (calculated as kg/m(2)) (>= 30/<25; OR=1.67, 95% CI 1.06 to 2.63), and a greater amount of resistance training (>= 271/0 to 45 min/week; OR=2.85, 95% CI 1.94 to 4.17) were associated with dietary supplement use. Twenty-two percent of dietary supplement users and 6% of nutritional supplement users reported one or more AEs. For combination products alone, 29% of users reported one or more AEs. Conclusions The prevalence of dietary supplement use in Navy and Marine Corps personnel was considerably higher than reported in civilian investigations for almost all types of dietary supplements, although similar to most other military services. Factors associated with dietary supplement use were similar to those reported in previous military and civilian investigations. Prevalence of self-reported AEs was very high, especially for combination products. C1 [Knapik, Joseph J.; Austin, Krista G.; Farina, Emily K.; Lieberman, Harris R.] US Army Res Inst Environm Med, Mil Nutr Div, 10 Gen Greene Ave, Natick, MA 01760 USA. [Knapik, Joseph J.; Steelman, Ryan A.] US Army Publ Hlth Ctr, Aberdeen Proving Ground, MD USA. [Knapik, Joseph J.; Austin, Krista G.; Farina, Emily K.] Oak Ridge Inst Sci & Educ, Belcamp, MD USA. [Trone, Daniel W.] Naval Hlth Res Ctr, San Diego, CA USA. RP Knapik, JJ (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, 10 Gen Greene Ave, Natick, MA 01760 USA. EM joseph.j.knapik.ctr@mail.mil FU Knowledge Preservation Program at the US Army Research Institute of Environmental Medicine (USARIEM); Army Institute of Public Health (AIPH); Center Alliance for Nutrition and Dietary Supplement Research FX This research was supported in part by an appointment to the Knowledge Preservation Program at the US Army Research Institute of Environmental Medicine (USARIEM) and the Army Institute of Public Health (AIPH) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and USARIEM. Funding was also provided by the Center Alliance for Nutrition and Dietary Supplement Research. NR 81 TC 2 Z9 2 U1 9 U2 9 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 2212-2672 EI 2212-2680 J9 J ACAD NUTR DIET JI J. Acad. Nutr. Diet. PD SEP PY 2016 VL 116 IS 9 BP 1423 EP 1442 DI 10.1016/j.jand.2016.02.015 PG 20 WC Nutrition & Dietetics SC Nutrition & Dietetics GA DU8QH UT WOS:000382478300009 PM 27083989 ER PT J AU Silin, V Kasianowicz, JJ Michelman-Ribeiro, A Panchal, RG Bavari, S Robertson, JWF AF Silin, Vitalii Kasianowicz, John J. Michelman-Ribeiro, Ariel Panchal, Rekha G. Bavari, Sina Robertson, Joseph W. F. TI Biochip for the Detection of Bacillus anthracis Lethal Factor and Therapeutic Agents against Anthrax Toxins SO MEMBRANES LA English DT Article DE anthrax; protective antigen; lethal factor; edema factor; therapeutic agents; screening; tethered bilayer membrane; biochip ID BILAYER-LIPID-MEMBRANES; ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY; PROTECTIVE ANTIGEN COMPONENT; SURFACE-PLASMON RESONANCE; AUREUS ALPHA-HEMOLYSIN; TETHERED-BILAYER; MONOCLONAL-ANTIBODIES; RECEPTOR-BINDING; ION-CHANNELS; IN-VITRO AB Tethered lipid bilayer membranes (tBLMs) have been used in many applications, including biosensing and membrane protein structure studies. This report describes a biosensor for anthrax toxins that was fabricated through the self-assembly of a tBLM with B. anthracis protective antigen ion channels that are both the recognition element and electrochemical transducer. We characterize the sensor and its properties with electrochemical impedance spectroscopy and surface plasmon resonance. The sensor shows a sensitivity similar to ELISA and can also be used to rapidly screen for molecules that bind to the toxins and potentially inhibit their lethal effects. C1 [Silin, Vitalii; Kasianowicz, John J.; Michelman-Ribeiro, Ariel; Robertson, Joseph W. F.] NIST, Phys Measurement Lab, Gaithersburg, MD 20899 USA. [Silin, Vitalii] NIST, NIST Ctr Neutron Res, Gaithersburg, MD 20899 USA. [Silin, Vitalii] Univ Maryland, Inst Biosci & Biotechnol Res, Rockville, MD 20899 USA. [Panchal, Rekha G.; Bavari, Sina] US Army Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Robertson, JWF (reprint author), NIST, Phys Measurement Lab, Gaithersburg, MD 20899 USA. EM vitalii.silin@nist.gov; john.kasianowicz@nist.gov; lasirenita54@yahoo.com; rekha.g.panchal.civ@mail.mil; sina.bavari.civ@mail.mil; joseph.robertson@nist.gov NR 83 TC 0 Z9 0 U1 6 U2 6 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 2077-0375 J9 MEMBRANES JI Membranes PD SEP PY 2016 VL 6 IS 3 AR 36 DI 10.3390/membranes6030036 PG 16 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA DU9BL UT WOS:000382511100001 ER PT J AU Losurdo, M Suvorova, A Rubanov, S Hingerl, K Brown, AS AF Losurdo, Maria Suvorova, Alexandra Rubanov, Sergey Hingerl, Kurt Brown, April S. TI Thermally stable coexistence of liquid and solid phases in gallium nanoparticles SO NATURE MATERIALS LA English DT Article ID INTERBAND-TRANSITIONS; OPTICAL-PROPERTIES; ALKALI-METALS; CLUSTERS; GA; TEMPERATURE; PLASMONS; FILMS AB Gallium (Ga), a group Ill metal, is of fundamental interest due to its polymorphism and unusual phase transition behaviours. New solid phases have been observed when Ga is confined at the nanoscale. Herein, we demonstrate the stable coexistence, from 180 K to 800 K, of the unexpected solid gamma-phase core and a liquid shell in substrate-supported Ga nanoparticles. We show that the support plays a fundamental role in determining Ga nanoparticle phases, with the driving forces for the nucleation of the gamma-phase being the Laplace pressure in the nanoparticles and the epitaxial relationship of this phase to the substrate. We exploit the change in the amplitude of the evolving surface plasmon resonance of Ga nanoparticle ensembles during synthesis to reveal in real time the solid core formation in the liquid Ga nanoparticle. Finally, we provide a general framework for understanding how nanoscale confinement, interfacial and surface energies, and crystalline relationships to the substrate enable and stabilize the coexistence of unexpected phases. C1 [Losurdo, Maria] CNR NANOTEC, Inst Nanotechnol, Via Orabona 4, I-70126 Bari, Italy. [Suvorova, Alexandra] Univ Western Australia, Ctr Microscopy Characterisat & Anal, Crawley, WA 6009, Australia. [Rubanov, Sergey] Univ Melbourne, Inst Bio21, 161 Barry St, Parkville, Vic 3010, Australia. [Hingerl, Kurt] Johannes Kepler Univ Linz, Ctr Surface & Nanoanalyt, Altenbergerstr 69, A-4040 Linz, Austria. [Brown, April S.] Army Res Off, Engn Sci Directorate, Durham, NC 27708 USA. [Brown, April S.] Duke Univ, Dept Elect & Comp Engn, Durham, NC 27708 USA. RP Losurdo, M (reprint author), CNR NANOTEC, Inst Nanotechnol, Via Orabona 4, I-70126 Bari, Italy.; Brown, AS (reprint author), Army Res Off, Engn Sci Directorate, Durham, NC 27708 USA.; Brown, AS (reprint author), Duke Univ, Dept Elect & Comp Engn, Durham, NC 27708 USA. EM maria.losurdo@cnr.it; april.brown@duke.edu RI Rubanov, Sergey/O-9798-2016 FU CNR STM programme; European Commission [112020, GA692034] FX We thank all of the students and colleagues in our groups who are actively involved with nanoparticle research. M.L. acknowledges the support of the CNR STM 2014 programme. M.L. and K.H. acknowledge the support of the European Commission under the 112020 grant TWINFUSYON (GA692034). NR 49 TC 4 Z9 4 U1 25 U2 26 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1476-1122 EI 1476-4660 J9 NAT MATER JI Nat. Mater. PD SEP PY 2016 VL 15 IS 9 BP 995 EP 1002 DI 10.1038/NMAT4705 PG 8 WC Chemistry, Physical; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Materials Science; Physics GA DU7YG UT WOS:000382429900018 PM 27454047 ER PT J AU Voiry, D Fullon, R Yang, JE Silva, CDCE Kappera, R Bozkurt, I Kaplan, D Lagos, MJ Batson, PE Gupta, G Mohite, AD Dong, L Er, DQ Shenoy, VB Asefa, T Chhowalla, M AF Voiry, Damien Fullon, Raymond Yang, Jieun Castro e Silva, Cecilia de Carvalho Kappera, Rajesh Bozkurt, Ibrahim Kaplan, Daniel Lagos, Maureen J. Batson, Philip E. Gupta, Gautam Mohite, Aditya D. Dong, Liang Er, Dequan Shenoy, Vivek B. Asefa, Tewodros Chhowalla, Manish TI The role of electronic coupling between substrate and 2D MoS2 nanosheets in electrocatalytic production of hydrogen SO NATURE MATERIALS LA English DT Article ID AMORPHOUS MOLYBDENUM SULFIDE; ACTIVE EDGE SITES; EVOLUTION REACTION; 2-DIMENSIONAL SEMICONDUCTORS; CATALYTIC-ACTIVITY; DISULFIDE; TRANSISTORS; GRAPHENE; CONTACTS; DEFECTS AB The excellent catalytic activity of metallic MoS2 edges for the hydrogen evolution reaction (HER) has led to substantial efforts towards increasing the edge concentration. The 2H basal plane is less active for the HER because it is less conducting and therefore possesses less efficient charge transfer kinetics. Here we show that the activity of the 2H basal planes of monolayer MoS2 nanosheets can be made comparable to state-of-the-art catalytic properties of metallic edges and the 1T phase by improving the electrical coupling between the substrate and the catalyst so that electron injection from the electrode and transport to the catalyst active site is facilitated. Phase-engineered low-resistance contacts on monolayer 2H-phase MoS2 basal plane lead to higher efficiency of charge injection in the nanosheets so that its intrinsic activity towards the HER can be measured. We demonstrate that onset potentials and Tafel slopes of similar to-0.1 V and similar to 50 mV per decade can be achieved from 2H-phase catalysts where only the basal plane is exposed. We show that efficient charge injection and the presence of naturally occurring sulfur vacancies are responsible for the observed increase in catalytic activity of the 2H basal plane. Our results provide new insights into the role of contact resistance and charge transport on the performance of two-dimensional MoS2 nanosheet catalysts for the HER. C1 [Voiry, Damien; Fullon, Raymond; Yang, Jieun; Castro e Silva, Cecilia de Carvalho; Kappera, Rajesh; Bozkurt, Ibrahim; Lagos, Maureen J.; Batson, Philip E.; Chhowalla, Manish] Rutgers State Univ, Mat Sci & Engn, 607 Taylor Rd, Piscataway, NJ 08854 USA. [Kaplan, Daniel] US Army RDECOM ARDEC, Acoust & Networked Sensors Div, Picatinny Arsenal, NJ 07806 USA. [Lagos, Maureen J.; Batson, Philip E.] Rutgers State Univ, Dept Phys, 136 Frelinghuysen Rd, Piscataway, NJ 08854 USA. [Lagos, Maureen J.; Batson, Philip E.] Rutgers State Univ, Inst Adv Mat Devices & Nanotechnol, 607 Taylor Rd, Piscataway, NJ 08854 USA. [Gupta, Gautam; Mohite, Aditya D.] Los Alamos Natl Lab, MPA Mat Synth & Integrated Devices 11, Los Alamos, NM 87545 USA. [Dong, Liang; Er, Dequan; Shenoy, Vivek B.] Univ Penn, Dept Mat Sci & Engn, 3231 Walnut St, Philadelphia, PA 19104 USA. [Asefa, Tewodros] Rutgers State Univ, Dept Chem & Chem Biol, 610 Taylor Rd, Piscataway, NJ 08854 USA. [Asefa, Tewodros] Rutgers State Univ, Dept Chem & Biochem Engn, 98 Brett Rd, Piscataway, NJ 08854 USA. RP Chhowalla, M (reprint author), Rutgers State Univ, Mat Sci & Engn, 607 Taylor Rd, Piscataway, NJ 08854 USA. EM manish1@rci.rutgers.edu RI Voiry, Damien/G-3541-2016; OI Voiry, Damien/0000-0002-1664-2839; Kappera, Rajesh/0000-0003-1792-4405 FU NSF [DGE 0903661, ECCS 1128335, CAREER CHE-1004218, DMR-0968937, NanoEHS-1134289, 0959905]; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-Brazil; Rutgers Energy Institute; LDRD program at LANL; US DOE, Office of Science, BES Award [DE-SC0005132]; US National Science Foundation [EFMA-542879, CMMI-1363203, CBET-1235870] FX M.C. and D.V. acknowledge financial support from NSF DGE 0903661 and ECCS 1128335. T.A. acknowledges financial assistance from NSF (CAREER CHE-1004218, DMR-0968937, NanoEHS-1134289, NSF-ACIF, and Special Creativity Grant).; C.d.C.C.e.S. acknowledges the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-Brazil, for a fellowship. J.Y. and M.C. acknowledge financial support from Rutgers Energy Institute. A.M. acknowledges LDRD program at LANL for funding this work. M.J.L. and P.E.B. acknowledge support from the US DOE, Office of Science, BES Award No. DE-SC0005132 and NSF No. 0959905. L.B., D.E., and V.B.S. acknowledge EFMA-542879, CMMI-1363203 and CBET-1235870 from the US National Science Foundation. NR 48 TC 15 Z9 15 U1 156 U2 158 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1476-1122 EI 1476-4660 J9 NAT MATER JI Nat. Mater. PD SEP PY 2016 VL 15 IS 9 BP 1003 EP 1009 DI 10.1038/NMAT4660 PG 7 WC Chemistry, Physical; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Materials Science; Physics GA DU7YG UT WOS:000382429900019 PM 27295098 ER PT J AU Kobes, JE Daryaei, I Howison, CM Bontrager, JG Sirianni, RW Meuillet, EJ Pagel, MD AF Kobes, Joseph E. Daryaei, Iman Howison, Christine M. Bontrager, Jordan G. Sirianni, Rachael W. Meuillet, Emmanuelle J. Pagel, Mark D. TI Improved Treatment of Pancreatic Cancer With Drug Delivery Nanoparticles Loaded With a Novel AKT/PDK1 Inhibitor SO PANCREAS LA English DT Article DE pancreatic cancer; AKT/PDK1 inhibitor; poly(lactic-co-glycolic) acid nanoparticles (PLGA); magnetic resonance imaging (MRI); apparent diffusion coefficient (ADC) ID PLECKSTRIN HOMOLOGY DOMAIN; PLGA NANOPARTICLES; ANTITUMOR-ACTIVITY; ANTICANCER DRUG; CELL LINE; IN-VITRO; MRI; THERAPY; VIVO; CARCINOMA AB Objectives: This research study sought to improve the treatment of pancreatic cancer by improving the drug delivery of a promising AKT/PDK1 inhibitor, PHT-427, in poly(lactic-co-glycolic) acid (PLGA) nanoparticles. Methods: PHT-427 was encapsulated in single-emulsion and double-emulsion PLGA nanoparticles (SE-PLGA-427 and DE-PLGA-427). The drug release rate was evaluated to assess the effect of the second PLGA layer of DE-PLGA-427. Ex vivo cryo-imaging and drug extraction from ex vivo organs was used to assess the whole-body biodistribution in an orthotopic model of MIA PaCa-2 pancreatic cancer. Anatomical magnetic resonance imaging (MRI) was used to noninvasively assess the effects of 4 weeks of nanoparticle drug treatment on tumor size, and diffusion-weighted MRI longitudinally assessed changes in tumor cellularity. Results: DE-PLGA-427 showed delayed drug release and longer drug retention in the pancreas relative to SE-PLGA-427. Diffusion-weighted MRI indicated a consistent decrease in cellularity during drug treatment with both types of drug-loaded nanoparticles. Both SE-and DE-PLGA-427 showed a 6-fold and 4-fold reduction in tumor volume relative to untreated tumors and an elimination of primary pancreatic tumor in 68% of the mice. Conclusions: These results indicated that the PLGA nanoparticles improved drug delivery of PHT-427 to pancreatic tumors, which improved the treatment of MIA PaCa-2 pancreatic cancer. C1 [Kobes, Joseph E.; Bontrager, Jordan G.] Univ Arizona, Biomed Engn Grad Interdisciplinary Program, Tucson, AZ USA. [Kobes, Joseph E.] US Mil Acad, Chem Life Sci Dept, West Point, NY 10996 USA. [Daryaei, Iman] Univ Arizona, Dept Chem & Biochem, Tucson, AZ USA. [Howison, Christine M.] Univ Arizona, Dept Biomed Engn, Tucson, AZ USA. [Sirianni, Rachael W.] Barrow Neurol Inst, Barrow Brain Tumor Res Ctr, Phoenix, AZ 85013 USA. [Meuillet, Emmanuelle J.; Pagel, Mark D.] Univ Arizona, Ctr Canc, Tucson, AZ USA. [Pagel, Mark D.] Univ Arizona, Dept Med Imaging, Tucson, AZ USA. RP Pagel, MD (reprint author), 1501 N Campbell Ave, Tucson, AZ 85724 USA. EM mpagel@u.arizona.edu FU National Institutes of Health [R01CA167183-01, P50 CA95060]; United States Army Advanced Civil Schooling Program FX This study was supported by National Institutes of Health grants R01CA167183-01 and P50 CA95060. J.E.K. acknowledges support from the United States Army Advanced Civil Schooling Program. E.J.M. has financial interests in PHusis Therapeutics, Inc (San Diego, CA), and the other authors have no conflicts of interest to declare. NR 54 TC 1 Z9 1 U1 10 U2 10 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0885-3177 EI 1536-4828 J9 PANCREAS JI Pancreas PD SEP PY 2016 VL 45 IS 8 BP 1158 EP 1166 DI 10.1097/MPA.0000000000000607 PG 9 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA DU6JZ UT WOS:000382322200016 PM 26918875 ER PT J AU Wilson, RM Mahmud, KW Hu, AZ Gorshkov, AV Hafezi, M Foss-Feig, M AF Wilson, Ryan M. Mahmud, Khan W. Hu, Anzi Gorshkov, Alexey V. Hafezi, Mohammad Foss-Feig, Michael TI Collective phases of strongly interacting cavity photons SO PHYSICAL REVIEW A LA English DT Article ID BOSE-EINSTEIN CONDENSATION; QUANTUM NONLINEAR OPTICS; RENORMALIZATION-GROUP; SINGLE-ATOM; BISTABILITY; DYNAMICS; SIMULATION; TRANSITIONS; POLARITONS; SYSTEMS AB We study a coupled array of coherently driven photonic cavities, which maps onto a driven-dissipative XY spin-1/2 model with ferromagnetic couplings in the limit of strong optical nonlinearities. Using a site-decoupled mean-field approximation, we identify steady-state phases with canted antiferromagnetic order, in addition to limit cycle phases, where oscillatory dynamics persist indefinitely. We also identify collective bistable phases, where the system supports two steady states among spatially uniform, antiferromagnetic, and limit cycle phases. We compare these mean-field results to exact quantum trajectory simulations for finite one-dimensional arrays. The exact results exhibit short-range antiferromagnetic order for parameters that have significant overlap with the mean-field phase diagram. In the mean-field bistable regime, the exact quantum dynamics exhibits real-time collective switching between macroscopically distinguishable states. We present a clear physical picture for this dynamics and establish a simple relationship between the switching times and properties of the quantum Liouvillian. C1 [Wilson, Ryan M.] US Naval Acad, Dept Phys, Annapolis, MD 21402 USA. [Wilson, Ryan M.; Gorshkov, Alexey V.; Hafezi, Mohammad] Kavli Inst Theoret Phys, Santa Barbara, CA 93106 USA. [Mahmud, Khan W.; Gorshkov, Alexey V.; Hafezi, Mohammad; Foss-Feig, Michael] Univ Maryland, NIST, Joint Quantum Inst, College Pk, MD 20742 USA. [Hu, Anzi] Amer Univ, Dept Phys, Washington, DC 20016 USA. [Gorshkov, Alexey V.] Univ Maryland, NIST, Joint Ctr Quantum Informat & Comp Sci, College Pk, MD 20742 USA. [Hafezi, Mohammad] Univ Maryland, Dept Elect Engn, College Pk, MD 20742 USA. [Hafezi, Mohammad] Univ Maryland, Inst Res Elect & Appl Phys, College Pk, MD 20742 USA. [Foss-Feig, Michael] US Army Res Lab, Adelphi, MD 20783 USA. RP Wilson, RM (reprint author), US Naval Acad, Dept Phys, Annapolis, MD 21402 USA.; Wilson, RM (reprint author), Kavli Inst Theoret Phys, Santa Barbara, CA 93106 USA. RI Gorshkov, Alexey/A-9848-2008 OI Gorshkov, Alexey/0000-0003-0509-3421 FU NSF [NSF PHY11-25915]; ONR; ARO; ARO MURI; ARL; AFOSR; Sloan Foundation; NSF PIF, at the JQI; NSF PFC at the JQI FX We thank Mohammad Maghrebi, Sarang Gopalakrishnan, and Jeremy Young for insightful discussions. R.W., K.M., A.G., and M.H. thank the KITP for hospitality. We acknowledge partial support from the NSF, ONR, ARO, ARO MURI, ARL, AFOSR, NSF PIF, and NSF PFC at the JQI, as well as the Sloan Foundation. This research was supported in part by the NSF under Grant No. NSF PHY11-25915. NR 85 TC 5 Z9 5 U1 8 U2 8 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9926 EI 2469-9934 J9 PHYS REV A JI Phys. Rev. A PD SEP 1 PY 2016 VL 94 IS 3 AR 033801 DI 10.1103/PhysRevA.94.033801 PG 9 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA DV3AY UT WOS:000382794600007 ER PT J AU Wald, I Fruchter, E Ginat, K Stolin, E Dagan, D Bliese, PD Quartana, PJ Sipos, ML Pine, DS Bar-Haim, Y AF Wald, I. Fruchter, E. Ginat, K. Stolin, E. Dagan, D. Bliese, P. D. Quartana, P. J. Sipos, M. L. Pine, D. S. Bar-Haim, Y. TI Selective prevention of combat-related post-traumatic stress disorder using attention bias modification training: a randomized controlled trial SO PSYCHOLOGICAL MEDICINE LA English DT Article DE Attention bias modification training; combat; post-traumatic stress disorder; prevention; stress ID MENTAL-HEALTH PROBLEMS; PSYCHOMETRIC PROPERTIES; PTSD; ANXIETY; SYMPTOMS; SOLDIERS; IRAQ; INTERVENTIONS; VARIABILITY; PSYCHOTHERAPY AB Background Efficacy of pre-trauma prevention for post-traumatic stress disorder (PTSD) has not yet been established in a randomized controlled trial. Attention bias modification training (ABMT), a computerized intervention, is thought to mitigate stress-related symptoms by targeting disruptions in threat monitoring. We examined the efficacy of ABMT delivered before combat in mitigating risk for PTSD following combat. Method We conducted a double-blind, four-arm randomized controlled trial of 719 infantry soldiers to compare the efficacy of eight sessions of ABMT (n = 179), four sessions of ABMT (n = 184), four sessions of attention control training (ACT; n = 180), or no-training control (n = 176). Outcome symptoms were measured at baseline, 6-month follow-up, 10 days following combat exposure, and 4 months following combat. Primary outcome was PTSD prevalence 4 months post-combat determined in a clinical interview using the Clinician-Administered PTSD Scale. Secondary outcomes were self-reported PTSD and depression symptoms, collected at all four assessments. Results PTSD prevalence 4 months post-combat was 7.8% in the no-training control group, 6.7% with eight-session ABMT, 2.6% with four-session ABMT, and 5% with ACT. Four sessions of ABMT reduced risk for PTSD relative to the no-training condition (odds ratio 3.13, 95% confidence interval 1.01-9.22, p < 0.05, number needed to treat = 19.2). No other between-group differences were found. The results were consistent across a variety of analytic techniques and data imputation approaches. Conclusions Four sessions of ABMT, delivered prior to combat deployment, mitigated PTSD risk following combat exposure. Given its low cost and high scalability potential, and observed number needed to treat, research into larger-scale applications is warranted. The ClinicalTrials.gov identifier is NCT01723215. C1 [Wald, I.; Bar-Haim, Y.] Tel Aviv Univ, Sch Psychol Sci, IL-69978 Tel Aviv, Israel. [Fruchter, E.; Ginat, K.; Stolin, E.; Dagan, D.] Israel Def Forces, Div Mental Hlth, Med Corps, Tel Aviv, Israel. [Bliese, P. D.] Univ South Carolina, Darla Moore Sch Business, Columbia, SC 29208 USA. [Quartana, P. J.; Sipos, M. L.] US Army Med Res & Mat Command, Ctr Mil Psychiat & Neurosci, Walter Reed Army Inst Res, Ft Detrick, MD USA. [Pine, D. S.] NIMH, Bethesda, MD USA. [Bar-Haim, Y.] Tel Aviv Univ, Sagol Sch Neurosci, Tel Aviv, Israel. RP Wald, I (reprint author), Tel Aviv Univ, Sch Psychol Sci, IL-69978 Tel Aviv, Israel. EM ilanwald@013net.net FU US Army Medical Research and Materiel Command (USAMRMC) [W81XWH-13-1-0003]; Iranian American Jewish Federation of New York FX The study was supported by US Army Medical Research and Materiel Command (USAMRMC), Award W81XWH-13-1-0003, and by the Iranian American Jewish Federation of New York. NR 35 TC 3 Z9 3 U1 8 U2 8 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0033-2917 EI 1469-8978 J9 PSYCHOL MED JI Psychol. Med. PD SEP PY 2016 VL 46 IS 12 BP 2627 EP 2636 DI 10.1017/S0033291716000945 PG 10 WC Psychology, Clinical; Psychiatry; Psychology SC Psychology; Psychiatry GA DU9WA UT WOS:000382567600015 PM 27377418 ER PT J AU Brovedani, V Sosa, S Poli, M Forino, M Varello, K Tubaro, A Pelin, M AF Brovedani, Valentina Sosa, Silvio Poli, Mark Forino, Martino Varello, Katia Tubaro, Aurelia Pelin, Marco TI A revisited hemolytic assay for palytoxin detection: Limitations for its quantitation in mussels SO TOXICON LA English DT Article DE Palytoxin; Hemolytic assay; Matrix effect; Mytilus galloprovincialis ID FRENCH MEDITERRANEAN COAST; OVATOXIN-A; PUTATIVE PALYTOXIN; STRUCTURAL INSIGHTS; OSTREOPSIS-OVATA; 1ST EVIDENCE; CORAL-REEF; TOXIN; SEAFOOD; ANALOGS AB Palytoxin (PLTX) and its analogues have been detected as seafood contaminants associated with a series of human foodborne poisonings. Due to a number of fatalities ascribed to the ingestion of PLTX-contaminated marine organisms, the development of methods for its detection in seafood has been recommended by the European Food Safety Authority (EFSA). Due to its feasibility, the spectrophotometric hemolytic assay is widely used to detect PLTX in different matrices, even though a standardized protocol is still lacking. Thus, on the basis of available assay procedures, a new standardized protocol was set up using purified human erythrocytes exposed to PLTX (working range: 3.9 x 10(-10)-2.5 x 10(-8) M) in a K-free phosphate buffered saline solution, employing a 5 h incubation at 41 degrees C. An intra-laboratory characterization demonstrated its sensitivity (limit of detection, LOD = 1.4 x 10(-1) M and quantitation, LOQ = 3.4 x 10(-10) M), accuracy (bias = -0.8%), repeatability (RSDr = 15% and 6% for intra- and inter-day repeatability, respectively) and specificity. However, the standardized method seems not to be suitable for PLTX quantitation in complex matrices, such as mussel (Mytilus galloprovincialis) extracts, at least below the limit suggested by EFSA (30 mu g PLTXs/Kg shellfish meat). Thus, the hemolytic assay for PLTX quantitation in seafood should be used only after a careful evaluation of the specific matrix effects. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Brovedani, Valentina; Sosa, Silvio; Tubaro, Aurelia; Pelin, Marco] Univ Trieste, Dept Life Sci, Via A Valerio 6, I-34127 Trieste, Italy. [Poli, Mark] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. [Forino, Martino] Univ Naples Federico II, Dept Pharm, I-80131 Naples, Italy. [Varello, Katia] Ist Zooprofilatt Sperimentale Piemonte Liguria &, Via Bologna 148, I-10154 Turin, Italy. RP Tubaro, A (reprint author), Univ Trieste, Dept Life Sci, Via A Valerio 6, I-34127 Trieste, Italy. EM valentina.brovedani@phd.units.it; ssosa@units.it; mark.a.poli.civ@mail.mil; forino@unina.it; varello@izsto.it; tubaro@units.it; mpelin@units.it FU Italian Ministry of Health (Progetto Ricerca Corrente, "Prevenzione delle patologie da biotossine algali: sviluppo di metodi di screening rapido") [IZSPLV 23/12 RC] FX This work was supported by a grant of the Italian Ministry of Health (Progetto Ricerca Corrente 2012, "Prevenzione delle patologie da biotossine algali: sviluppo di metodi di screening rapido", IZSPLV 23/12 RC). NR 60 TC 0 Z9 0 U1 4 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD SEP 1 PY 2016 VL 119 BP 225 EP 233 DI 10.1016/j.toxicon.2016.06.013 PG 9 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA DT5OK UT WOS:000381532300028 PM 27343702 ER PT J AU Fang, X Jeong, JH Long, X Park, SJ Wang, D Shuai, M Wei, R Li, C Li, S Zhang, S Duran, MB Lo, KW Tsao, SW Glaser, R Luo, Z Feng, X Tian, Y Luo, JL AF Fang, X. Jeong, J-H Long, X. Park, S-J Wang, D. Shuai, M. Wei, R. Li, C. Li, S. Zhang, S. Duran, M. B. Lo, K-W Tsao, S. W. Glaser, R. Luo, Z. Feng, X. Tian, Y. Luo, J-L TI IKK alpha-mediated biogenesis of miR-196a through interaction with Drosha regulates the sensitivity of cancer cells to radiotherapy SO CELL DEATH AND DIFFERENTIATION LA English DT Article ID NF-KAPPA-B; EPSTEIN-BARR-VIRUS; NASOPHARYNGEAL CARCINOMA; GENE-EXPRESSION; MICROPROCESSOR COMPLEX; MICRORNA MATURATION; PROSTATE-CANCER; METASTASIS; ACTIVATION; PHOSPHORYLATION AB Radioresistance is a major obstacle in successful clinical cancer radiotherapy, and the underlying mechanisms are not clear. Here we show that IKK alpha-mediated miR-196a biogenesis via interaction with Drosha regulates the sensitivity of nasopharyngeal carcinoma (NPC) cells to radiotherapy. Phosphorylation of IKK alpha at T23 site (p-IKK alpha T23) promotes the binding of IKK alpha to Drosha that accelerates the processing of miR-196a primary transcripts, leading to increased expressions of both precursor and mature miR-196a. Dephosphorylation of p-IKK alpha T23 downregulates miR-196a expression and promotes the resistance of NPC cells to radiation treatment. The miR-196a mimic suppresses while its inhibitor promotes the resistance of NPC to radiation treatment. Importantly, the expression of p-IKK alpha T23 is positively related to the expression of miR-196a in human NPC tissues, and expression of p-IKK alpha T23 and miR-196a is inversely correlated with NPC clinical radioresistance. Thus, our studies establish a novel mechanistic link between the inactivation of IKK alpha T23-Drosha-miR-196a pathway and NPC radioresistance, and de-inactivation of IKK alpha T23-Drosha-miR-196a pathway would be an efficient way to restore the sensitivity of radioresistant NPC to radiotherapy. C1 [Fang, X.; Long, X.; Shuai, M.; Wei, R.; Li, C.; Li, S.; Zhang, S.; Feng, X.; Tian, Y.; Luo, J-L] Cent S Univ, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China. [Fang, X.; Jeong, J-H; Long, X.; Park, S-J; Wang, D.; Shuai, M.; Wei, R.; Duran, M. B.; Feng, X.; Luo, J-L] Scripps Res Inst, Dept Canc Biol, Florida Campus,USA,130 Scripps Way, Jupiter, FL 33458 USA. [Lo, K-W] Chinese Univ Hong Kong, Fac Med, Dept Anat & Cellular Pathol, Hong Kong, Hong Kong, Peoples R China. [Tsao, S. W.] Univ Hong Kong, Li Ka Shing Fac Med, Dept Anat, Hong Kong, Hong Kong, Peoples R China. [Glaser, R.] Ohio State Univ, Inst Behav Med Res, Dept Mol Virol Immunol & Med Genet, Columbus, OH USA. [Luo, Z.] Cent S Univ, Sch Life Sci, Changsha 410008, Hunan, Peoples R China. RP Feng, X; Luo, JL (reprint author), Scripps Res Inst, Dept Canc Biol, Florida Campus,USA,130 Scripps Way, Jupiter, FL 33458 USA.; Feng, X; Tian, Y; Luo, JL (reprint author), Cent S Univ, Xiangya Hosp, Florida Campus,USA,130 Scripps Way, Jupiter, FL 33458 USA. EM fxp1029@aliyun.cn; yongquantian2013@163.com; jlluo@scripps.edu FU United States Department of Defense [W81XWH-09-1-0533]; National Institute of Health [1R01CA140956, 1R21NS073098]; China Nature Science Foundation [81472847, 81372905]; China Scholarship Council (CSC); UICC YY fellowship [Feng2014/YY1/315514] FX We thank Dr. Xiaoli Tang and Dr. Bharat Ramratnam at Warren Alpert Medical School of Brown University for kindly providing us with GFP-Drosha plasmid. This work was supported by grants from the United States Department of Defense (W81XWH-09-1-0533) and National Institute of Health (1R01CA140956, 1R21NS073098) to J-LL, and China Nature Science Foundation (81472847, 81372905) to J-LL and XPF, by Scholarships from China Scholarship Council (CSC) to XPF and XL, and an UICC YY fellowship (Feng2014/YY1/315514) to XPF. NR 47 TC 0 Z9 0 U1 1 U2 1 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1350-9047 EI 1476-5403 J9 CELL DEATH DIFFER JI Cell Death Differ. PD SEP PY 2016 VL 23 IS 9 BP 1471 EP 1482 DI 10.1038/cdd.2016.32 PG 12 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA DS8ZY UT WOS:000381072800005 PM 27058318 ER PT J AU Camacho, M Zaghi, S Piccin, O Certal, V AF Camacho, Macario Zaghi, Soroush Piccin, Ottavio Certal, Victor TI Expansion sphincter pharyngoplasty for obstructive sleep apnea: an update to the recent meta-analysis SO EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY LA English DT Letter DE Expansion sphincter pharyngoplasty; Sleep apnea syndromes; Meta-analysis C1 [Camacho, Macario] Tripler Army Med Ctr, Div Sleep Surg & Med, Otolaryngol Head & Neck Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. [Zaghi, Soroush] Stanford Hosp & Clin, Div Sleep Surg, Dept Otolaryngol Head & Neck Surg, Stanford, CA 95304 USA. [Piccin, Ottavio] S Orsola Malpighi Univ Hosp, Dept Otolaryngol, Via Massarenti 9, I-40138 Bologna, Italy. [Certal, Victor] Hosp CUF, Dept Otorhinolaryngol, Sleep Med Ctr, P-4100180 Oporto, Portugal. [Certal, Victor] CHEDV, P-4100180 Oporto, Portugal. [Certal, Victor] Univ Porto, Ctr Res Hlth Technol & Informat Syst, CINTESIS, P-4200450 Oporto, Portugal. RP Camacho, M (reprint author), Tripler Army Med Ctr, Div Sleep Surg & Med, Otolaryngol Head & Neck Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM drcamachoent@yahoo.com RI FMUP, CINTESIS/C-6631-2014; OI FMUP, CINTESIS/0000-0001-7248-2086; piccin, ottavio/0000-0002-0184-7460 NR 7 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0937-4477 EI 1434-4726 J9 EUR ARCH OTO-RHINO-L JI Eur. Arch. Oto-Rhino-Laryn. PD SEP PY 2016 VL 273 IS 9 BP 2857 EP 2858 DI 10.1007/s00405-016-3929-1 PG 2 WC Otorhinolaryngology SC Otorhinolaryngology GA DT1TD UT WOS:000381264100077 PM 26993655 ER PT J AU McClung, JP AF McClung, James P. TI Iron Supplementation in Children with Malaria: Timing the Treatment SO JOURNAL OF NUTRITION LA English DT Editorial Material ID DEFICIENCY; HEPCIDIN; DISEASE; BURDEN C1 [McClung, James P.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. RP McClung, JP (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. EM james.p.mcclung8.civ@mail.mil NR 14 TC 0 Z9 0 U1 3 U2 3 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-3166 EI 1541-6100 J9 J NUTR JI J. Nutr. PD SEP PY 2016 VL 146 IS 9 BP 1623 EP 1624 DI 10.3945/jn.116.236463 PG 2 WC Nutrition & Dietetics SC Nutrition & Dietetics GA DU7VN UT WOS:000382422800001 PM 27440262 ER PT J AU Andrade, R AF Andrade, Robert TI Glenohumeral Synovial Chondromatosis SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Editorial Material ID SHOULDER C1 [Andrade, Robert] US Army, Cavalry Regiment 2, Vilseck, Germany. RP Andrade, R (reprint author), US Army, Cavalry Regiment 2, Vilseck, Germany. NR 2 TC 0 Z9 0 U1 1 U2 1 PU J O S P T PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 EI 1938-1344 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD SEP PY 2016 VL 46 IS 9 BP 809 EP 809 PG 1 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA DU9DA UT WOS:000382515200012 PM 27581180 ER PT J AU Mitrophanov, AY Szlam, F Sniecinski, RM Levy, JH Reifman, J AF Mitrophanov, Alexander Y. Szlam, Fania Sniecinski, Roman M. Levy, Jerrold H. Reifman, Jaques TI A Step Toward Balance: Thrombin Generation Improvement via Procoagulant Factor and Antithrombin Supplementt.ition SO ANESTHESIA AND ANALGESIA LA English DT Article ID PROTHROMBIN COMPLEX CONCENTRATE; TRAUMA-INDUCED COAGULOPATHY; RECOMBINANT FACTOR VIIA; FRESH-FROZEN PLASMA; DILUTIONAL COAGULOPATHY; CARDIOPULMONARY BYPASS; COMPUTATIONAL ANALYSIS; BLOOD-COAGULATION; MODEL; HEMODILUTION AB BACKGROUND: The use of prothrombin complex concentrates in trauma- and surgery-induced coagulopathy is complicated by the possibility of thromboembolic events. To explore the effects of these agents on thrombin generation (TG), we investigated combinations of coagulation factors equivalent to 3- and 4-factor prothrombin complex concentrates with and without added antithrombin (AT), as well as recombinant factor Vila (rFVlla), in a dilutional model. These data were then used to develop a computational model to test whether such a model could predict the TG profiles of these agents used to treat dilutional coagulopathy. METHODS: We measured TG in plasma collected from 10 healthy volunteers using Calibrated Automated Thrombogram. TG measurements were performed in undiluted plasma, 3-fold saline- diluted plasma, and diluted plasma supplemented with the following factors: rFVIIa (group rFVIIa); factors (F)II, FIX, FX, and AT (group "combination of coagulation factors" [CCF]-AT); or FII, FVII, FIX, and FX (group CCF-FVII). We extended an existing computational model of TG to include additional reactions that impact the Calibrated Automated Thrombogram readout. We developed and applied a computational strategy to train the model using only a subset of the obtained TG data and used the remaining data for model validation. RESULTS: rFVIIa decreased lag time and the time to thrombin peak generation beyond their predilution levels (P < 0.001) but did not restore normal thrombin peak height (P < 0.001). CCFFVII supplementation decreased lag time (P = 0.034) and thrombin peak time (P < 0.001) and increased both peak height (P < 0.001) and endogenous thrombin potential (P = 0.055) beyond their predilution levels. CCF-AT supplementation in diluted plasma resulted in an improvement in TG without causing the exaggerated effects of rFVlla and CCF-FV1I supplementation. The differences between the effects of CCF-AT and supplementation with rFVlla and CCF-FVII were significant for lag time (P < 0.001 and P = 0.005, respectively), time to thrombin peak (P < 0.001 and P = 0.004, respectively), velocity index (P < 0.001 and P = 0.019, respectively), thrombin peak height (P < 0.001 for both comparisons), and endogenous thrombin potential (P = 0.034 and P = 0.019, respectively). The computational model generated subject-specific predictions and identified typical patterns of TG improvement. CONCLUSIONS: In this study of the effects of hemodilution, CCF-AT supplementation improved the dilution-impaired plasma TG potential in a more balanced way than either rFVlla alone or PCF-FVII supplementation. Predictive computational modeling can guide plasma dilution/supplementation experiments. C1 [Mitrophanov, Alexander Y.; Reifman, Jaques] US Army Med Res & Mat Command, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, 504 Scott St, Ft Detrick, MD 21702 USA. [Szlam, Fania; Sniecinski, Roman M.] Emory Univ, Sch Med, Dept Anesthesiol, Atlanta, GA 30322 USA. [Levy, Jerrold H.] Duke Univ, Sch Med, Dept Anesthesiol, Durham, NC USA. [Levy, Jerrold H.] Duke Univ, Sch Med, Dept Surg, Durham, NC USA. RP Mitrophanov, AY; Reifman, J (reprint author), US Army Med Res & Mat Command, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, 504 Scott St, Ft Detrick, MD 21702 USA. EM alex@bhsai.org; jaques.reifman.civ@mail.mil FU US Army Network Science Initiative, US Army Medical Research and Materiel Command, Fort Detrick, MD FX This study was supported by the US Army Network Science Initiative, US Army Medical Research and Materiel Command, Fort Detrick, MD. NR 55 TC 4 Z9 4 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD SEP PY 2016 VL 123 IS 3 BP 535 EP 546 DI 10.1213/ANE.0000000000001361 PG 12 WC Anesthesiology SC Anesthesiology GA DT9RA UT WOS:000381838800003 PM 27541717 ER PT J AU Doona, CJ Feeherry, FE Setlow, B Wang, SW Li, W Nichols, FC Talukdar, PK Sarker, MR Li, YQ Shen, A Setlow, P AF Doona, Christopher J. Feeherry, Florence E. Setlow, Barbara Wang, Shiwei Li, William Nichols, Frank C. Talukdar, Prabhat K. Sarker, Mahfuzur R. Li, Yong-Qing Shen, Aimee Setlow, Peter TI Effects of High-Pressure Treatment on Spores of Clostridium Species SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID BACILLUS-SUBTILIS SPORES; DIPICOLINIC ACID; RAMAN-SPECTROSCOPY; DIFFICILE SPORES; GERMINATION PROTEINS; CONTRAST MICROSCOPY; PERFRINGENS SPORES; BACTERIAL-SPORES; LIGHT-SCATTERING; SPOVA PROTEINS AB This work analyzes the high-pressure (HP) germination of spores of the food-borne pathogen Clostridium perfringens (with inner membrane [IM] germinant receptors [GRs]) and the opportunistic pathogen Clostridium difficile (with no IM GRs), which has growing implications as an emerging food safety threat. In contrast to those of spores of Bacillus species, mechanisms of HP germination of clostridial spores have not been well studied. HP treatments trigger Bacillus spore germination through spores' IM GRs at similar to 150 MPa or through SpoVA channels for release of spores' dipicolinic acid (DPA) at >= 400 MPa, and DPA-less spores have lower wet heat resistance than dormant spores. We found that C. difficile spores exhibited no germination events upon 150-MPa treatment and were not heat sensitized. In contrast, 150-MPa-treated unactivated C. perfringens spores released DPA and became heat sensitive, although most spores did not complete germination by fully rehydrating the spore core, but this treatment of heat-activated spores led to almost complete germination and greater heat sensitization. Spores of both clostridial organisms released DPA during 550-MPa treatment, but C. difficile spores did not complete germination and remained heat resistant. Heat-activated 550-MPa-HP-treated C. perfringens spores germinated almost completely and became heat sensitive. However, unactivated 550-MPa-treated C. perfringens spores did not germinate completely and were less heat sensitive than spores that completed germination. Since C. difficile and C. perfringens spores use different mechanisms for sensing germinants, our results may allow refinement of HP methods for their inactivation in foods and other applications and may guide the development of commercially sterile low-acid foods. IMPORTANCE Spores of various clostridial organisms cause human disease, sometimes due to food contamination by spores. Because of these spores' resistance to normal decontamination regimens, there is continued interest in ways to kill spores without compromising food quality. High hydrostatic pressure (HP) under appropriate conditions can inactivate bacterial spores. With growing use of HP for food pasteurization, advancement of HP for commercial production of sterile low-acid foods requires understanding of mechanisms of spores' interactions with HP. While much is known about HP germination and inactivation of spores of Bacillus species, how HP germinates and inactivates clostridial spores is less well understood. In this work we have tried to remedy this information deficit by examining germination of spores of Clostridium difficile and Clostridium perfringens by several HP and temperature levels. The results may give insight that could facilitate more efficient methods for spore eradication in food sterilization or pasteurization, biodecontamination, and health care. C1 [Doona, Christopher J.; Feeherry, Florence E.] US Army, Natick Soldier RD&E Ctr, Warfighter Directorate, Natick, MA 01760 USA. [Setlow, Barbara; Setlow, Peter] UConn Hlth, Dept Mol Biol & Biophys, Farmington, CT 06030 USA. [Setlow, Barbara; Wang, Shiwei; Li, Yong-Qing] East Carolina Univ, Dept Phys, Greenville, NC 27858 USA. [Nichols, Frank C.] UConn Hlth, Dept Oral Hlth & Diagnost Sci, Farmington, CT 06030 USA. [Talukdar, Prabhat K.; Sarker, Mahfuzur R.] Oregon State Univ, Dept Biomed Sci, Corvallis, OR 97331 USA. [Shen, Aimee] Univ Vermont, Dept Microbiol & Mol Genet, Burlington, VT 05405 USA. [Wang, Shiwei] Chinese Acad Sci, Inst Microbiol, State Key Lab Microbial Resources, Beijing, Peoples R China. RP Setlow, P (reprint author), UConn Hlth, Dept Mol Biol & Biophys, Farmington, CT 06030 USA. EM setlow@nso2.uchc.edu FU HHS \ NIH \ National Institute of General Medical Sciences (NIGMS) [R01GM108684]; HHS \ NIH \ National Institute of Dental and Craniofacial Research (NIDCR) [DE 021055]; DOD \ United States Army \ Army Research Office (ARO) [W911NF-12-2-0024] FX This work, including the efforts of Aimee Shen, was funded by HHS vertical bar NIH vertical bar National Institute of General Medical Sciences (NIGMS) (R01GM108684). This work, including the efforts of Frank Nichols, was funded by HHS vertical bar NIH vertical bar National Institute of Dental and Craniofacial Research (NIDCR) (DE 021055). This work, including the efforts of Shiwei Wang and Yong-Qing Li, was funded by DOD vertical bar United States Army vertical bar Army Research Office (ARO) (W911NF-12-2-0024). This work, including the efforts of Shiwei Wang and Yong-Qing Li, was funded by DOD vertical bar United States Army vertical bar Army Research Office (ARO) (W911NF-12-2-0024). NR 49 TC 0 Z9 0 U1 19 U2 23 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 EI 1098-5336 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD SEP PY 2016 VL 82 IS 17 BP 5287 EP 5297 DI 10.1128/AEM.01363-16 PG 11 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA DT5DI UT WOS:000381500700023 PM 27316969 ER PT J AU Poramathikul, K Bodhidatta, L Chiek, S Oransathid, W Ruekit, S Nobthai, P Lurchachaiwong, W Serichantalergs, O Lon, C Swierczewski, B AF Poramathikul, Kamonporn Bodhidatta, Ladaporn Chiek, Sivhour Oransathid, Wilawan Ruekit, Sirigade Nobthai, Panida Lurchachaiwong, Woradee Serichantalergs, Oralak Lon, Chanthap Swierczewski, Brett TI Multidrug-Resistant Shigella Infections in Patients with Diarrhea, Cambodia, 2014-2015 SO EMERGING INFECTIOUS DISEASES LA English DT Article ID SPECTRUM-BETA-LACTAMASE; SONNEI; STRAINS AB We observed multidrug resistance in 10 (91%) of 11 Shigella isolates from a diarrhea! surveillance study in Cambodia. One isolate was resistant to fluoroquinolones and cephalo-sporins and showed decreased susceptibility to azithromycin. We found mutations in gyrA, parC, beta-lactamase, and mphA genes. Multidrug resistance increases concern about shigellosis treatment options. C1 [Poramathikul, Kamonporn; Bodhidatta, Ladaporn; Oransathid, Wilawan; Ruekit, Sirigade; Nobthai, Panida; Lurchachaiwong, Woradee; Serichantalergs, Oralak; Swierczewski, Brett] Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Chiek, Sivhour] Battambang Prov Referral Hosp, Battambang, Cambodia. [Lon, Chanthap] Armed Forces Res Inst Med Sci, Phnom Penh, Cambodia. RP Bodhidatta, L (reprint author), Armed Forces Res Inst Med Sci, Dept Enter Dis, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM LadapomB.fsn@afrims.org FU Global Emerging Infectious Disease Surveillance, a division of the Armed Forces Health Surveillance Center FX This work is supported by the Global Emerging Infectious Disease Surveillance, a division of the Armed Forces Health Surveillance Center. NR 15 TC 0 Z9 0 U1 1 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD SEP PY 2016 VL 22 IS 9 BP 1640 EP 1643 DI 10.3201/eid2209.152058 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA DU1GJ UT WOS:000381955900018 PM 27532684 ER PT J AU Knox, RL Latrubesse, EM AF Knox, Richard L. Latrubesse, Edgardo M. TI A geomorphic approach to the analysis of bedload and bed morphology of the Lower Mississippi River near the Old River Control Structure SO GEOMORPHOLOGY LA English DT Article DE Lower Mississippi River; Old River Control Structure; Bed forms; Bedload; Geomorphic change; Channel geometry ID LOUISIANA; TRENDS; ADJUSTMENT; BEDFORMS; DYNAMICS; REGIME; WATER AB The Mississippi River is the ultimate single-thread meandering river. Five hundred kilometers upstream from its mouth, about 25% of the river's discharge and sediment load is diverted into the Atchafalaya River. This diversion is controlled by the Old River Control Structure (ORCS), built by the U.S. Army Corps of Engineers (USACE) in stages since 1961, to stop the avulsion of the Mississippi River into the Atchafalaya. The effects of ORCS on sediment and water discharge and geomorphic change to the Lower Mississippi River (LMR) channel are not yet completely understood and require placing the river into a geomorphic context, first classifying the channel into similar categories before evaluating change. The objectives of this study are to estimate the LMR bedload, develop and apply a geomorphic classification of the LMR near the ORCS, and explore geomorphic change within the classified areas. We studied a 115-km-long stretch between ORCS and Baton Rouge that is highly impacted by engineering. We used six sets of bathymetric multibeam echosounder surveys conducted by the USACE, multitemporal cartographies, and a field survey supported by multibeam echosounder bathymetry, acoustic Doppler current profiler (ADCP) measurements, sediment samples collection, and geomorphic observations. A three-dimensional method for estimating bedload from time-elapsed bathymetric surveys was developed and applied on seven sets of time-elapsed surveys downstream from ORCS from 2010, 2011, and 2012. We estimate that the fraction of bedload as a percentage of total sand load between 2003 and 2011 was 13.2%. A bedform classification scheme, based on bedform height was developed. The bed was almost completely mantled by sandy bedforms above the -24-m isoline. The studied reach was divided into ten zones according to four geomorphic types based on channel planform, geologic controls, presence of islands, and other morphometric parameters. These zones were shown to be physically distinct in terms of bedform location, depth to bedform size, channel sinuosity, channel width-to-depth ratios, and adjustments in the thalweg and channel width from 1948 to 2012. The 1948 to 1975 period displayed a relatively large amount of thalweg aggradation, with a spatial average of 1.8 m and an average channel narrowing of 80 m. The 1975 to 2012 period had much lower spatial aggradation of 0.5 m and a lower average channel narrowing of 35 m. Thalweg sinuosity did not adjust very much, with an average reduction of 0.02 from 1948 to 2012 and an average of zero adjustment between 1975 and 2012. The shape and spatial extent of a very large, anomalous bar near ORCS varied at seasonal and decadal timescales and may be influenced by the ORCS. Bed morphology was specific to geomorphic zones, which were shown to be physically significant, and should be employed in future studies of large rivers. (C) 2016 Elsevier B.V. All rights reserved. C1 [Knox, Richard L.] US Mil Acad, Dept Geog & Environm Engn, West Point, NY 10996 USA. [Latrubesse, Edgardo M.] Univ Texas Austin, Dept Geog & Environm, A3100, Austin, TX 78712 USA. RP Latrubesse, EM (reprint author), Univ Texas Austin, Dept Geog & Environm, A3100, Austin, TX 78712 USA. EM latrubesse@austin.utexas.edu NR 42 TC 0 Z9 0 U1 5 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-555X EI 1872-695X J9 GEOMORPHOLOGY JI Geomorphology PD SEP 1 PY 2016 VL 268 BP 35 EP 47 DI 10.1016/j.geomorph.2016.05.034 PG 13 WC Geography, Physical; Geosciences, Multidisciplinary SC Physical Geography; Geology GA DT0JA UT WOS:000381168600004 ER PT J AU O'Brien, HK Ogunniyi, AA Shaheen, W Ryu, SH AF O'Brien, Heather K. Ogunniyi, Aderinto A. Shaheen, William Ryu, Sei-Hyung TI Turn-ON of High-Voltage SiC Thyristors for Fast-Switching Applications SO IEEE JOURNAL OF EMERGING AND SELECTED TOPICS IN POWER ELECTRONICS LA English DT Article; Proceedings Paper CT 1st Annual IEEE Workshop on Wide Bandgap Power Devices and Applications (WiPDA) CY OCT 27-29, 2013 CL Ohio State Univ, Columbus, OH SP IEEE, Power Sources Manufacturers Assoc, IEEE Power Elect Soc, Electron Devices Soc HO Ohio State Univ DE Burst switching; power semiconductor switches; semiconductor device testing; silicon carbide; thyristors ID P-TYPE; CM(2) AB This paper is focused on the characterization of the turn-ON transition of high-voltage SiC thyristors of different epi-layer thicknesses and active-area sizes to determine their suitability and limitations in high-d I/dt, fast-switching applications. The unique aspects of this paper include the very high current density being switched through the thyristors over a short period of time at initial turn-ON, resulting in very high instantaneous dissipated power over the small device volume. The devices that were characterized were 6-kV, 0.5-cm(2) thyristors; 10-kV, 1.05-cm(2) thyristors; and 15-kV, 1.05-cm(2) thyristors, all fabricated by Cree, Inc. (now Wolfspeed) for the U.S. Army Research Laboratory. The highest dI/dt and the current density were 13 kA/ms and 3.2 kA/cm(2) for a parallel pair of 0.5-cm(2) thyristors, with pulsed current peaking 250 ns from initial gate trigger. All devices evaluated were capable of switching a current pulse >2 kA/cm(2) within a period of less than 2 mu s. These evaluations have broad application in helping to inform SiC device design tradeoffs for increasing epi thickness, increasing device area, and the effects of lifetime enhancement processes. Results are also presented for initial exploration of fast-switching applications for these devices. C1 [O'Brien, Heather K.; Ogunniyi, Aderinto A.] US Army Res Lab, Adelphi, MD 20783 USA. [Shaheen, William] Berkeley Res Associates Inc, Beltsville, MD 20705 USA. [Ryu, Sei-Hyung] Wolfspeed, Durham, NC 27709 USA. RP O'Brien, HK (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM heather.k.obrien.civ@mail.mil; aderinto.a.ogunniyi.civ@mail.mil; william.d.shaheen.ctr@mail.mil; sei-hyung.ryu@wolfspeed.com NR 18 TC 0 Z9 0 U1 2 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 2168-6777 J9 IEEE J EM SEL TOP P JI IEEE J. Emerg. Sel. Top. Power Electron. PD SEP PY 2016 VL 4 IS 3 SI SI BP 772 EP 779 DI 10.1109/JESTPE.2016.2587245 PG 8 WC Engineering, Electrical & Electronic SC Engineering GA DT4HU UT WOS:000381441600009 ER PT J AU Veliadis, V Steiner, B Lawson, K Bayne, SB Urciuoli, D Ha, HC AF Veliadis, Victor Steiner, B. Lawson, K. Bayne, S. B. Urciuoli, D. Ha, H. C. TI Suitability of N-ON Recessed Implanted Gate Vertical-Channel SiC JFETs for Optically Triggered 1200 V Solid-State Circuit Breakers SO IEEE JOURNAL OF EMERGING AND SELECTED TOPICS IN POWER ELECTRONICS LA English DT Article; Proceedings Paper CT 1st Annual IEEE Workshop on Wide Bandgap Power Devices and Applications (WiPDA) CY OCT 27-29, 2013 CL Ohio State Univ, Columbus, OH SP IEEE, Power Sources Manufacturers Assoc, IEEE Power Elect Soc, Electron Devices Soc HO Ohio State Univ DE 1200 V; bidirectional; fault isolation; four quadrant; hard switching; high temperature; high voltage; JFET; normally ON (N-ON); pulsing; reliability; SiC; solid-state circuit breaker (SSCB) AB A requirement for the commercialization of power SiC transistors is their long term reliable operation under the hard-switching conditions and high temperatures encountered in the field. Normally ON 1200 V vertical-channel implanted-gate SiC junction field effect transistors (JFETs), designed for high-power bidirectional (four quadrant) solid-state-circuit-breaker (SSCB) applications, were repetitively pulse hard switched at 150 degrees C from a 1200 V blocking state to an ON-state current of 115 A, which is in excess of 13 times the JFET's 250-W/cm(2) rated current at 150 degrees C. The JFETs were fabricated in seven photolithographic levels with a single masked ion-implantation forming the p+ gates and guard rings, and with no epitaxial regrowth. The pulsed testing was performed using a low inductance RLC circuit. In this circuit, energy initially stored in a capacitor is discharged in a load resistor through the JFET under test. The JFET hard-switch stressing included over 2.4 million 1200 V/115-A hard-switch events at 150 degrees C and at a repetition rate of 10 Hz. The peak energies and powers dissipated by the JFET at each hard-switch event were 73.2 mJ and 68.2 kW, respectively. The current rise rate was 166 A/mu s and the pulse full width at half maximum (FWHM) was 1.8 mu s. After over 2.4 million hard-switch events at 150 degrees C, the JFET blocking voltage characteristics remained unchanged while the ON-state conduction slightly improved, which indicate reliable operation. An optically triggered SSCB, based on these rugged JFET, is proposed. C1 [Veliadis, Victor; Ha, H. C.] PowerAmerica, Raleigh, NC 27695 USA. [Steiner, B.; Lawson, K.; Bayne, S. B.] Texas Tech Univ, Lubbock, TX 79409 USA. [Urciuoli, D.] US Army, Res Lab, Adelphi, MD 20783 USA. RP Veliadis, V (reprint author), PowerAmerica, Raleigh, NC 27695 USA. EM jvveliad@ncsu.edu NR 13 TC 0 Z9 0 U1 3 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 2168-6777 J9 IEEE J EM SEL TOP P JI IEEE J. Emerg. Sel. Top. Power Electron. PD SEP PY 2016 VL 4 IS 3 SI SI BP 874 EP 879 DI 10.1109/JESTPE.2016.2583430 PG 6 WC Engineering, Electrical & Electronic SC Engineering GA DT4HU UT WOS:000381441600019 ER PT J AU Benson, JD Bubulac, LO Jaime-Vasquez, M Lennon, CM Arias, JM Smith, PJ Jacobs, RN Markunas, JK Almeida, LA Stoltz, A Wijewarnasuriya, PS Peterson, J Reddy, M Jones, K Johnson, SM Lofgreen, DD AF Benson, J. D. Bubulac, L. O. Jaime-Vasquez, M. Lennon, C. M. Arias, J. M. Smith, P. J. Jacobs, R. N. Markunas, J. K. Almeida, L. A. Stoltz, A. Wijewarnasuriya, P. S. Peterson, J. Reddy, M. Jones, K. Johnson, S. M. Lofgreen, D. D. TI Analysis of Etched CdZnTe Substrates SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE CdZnTe substrate; molecular beam epitaxy; polishing damage; impurity contamination ID MOLECULAR-BEAM EPITAXY; DUAL-BAND HGCDTE; DEFECTS AB State-of-the-art as-received (112)B CdZnTe substrates have been examined for surface impurity contamination and polishing residue. Two 4 cm x 4 cm and one 6 cm x 6 cm (112)B state-of-the-art as-received CdZnTe wafers were analyzed. A maximum surface impurity concentration of Al = 1.7 x 10(15) atoms cm(-2), Si = 3.7 x 10(13) atoms cm(-2), Cl = 3.12 x 10(15) atoms cm(-2), S = 1.7 x 10(14) atoms cm(-2), P = 1.1 x 10(14) atoms cm(-2), Fe = 1.0 x 10(13) atoms cm(-2), Br = 1.2 x 10(14) atoms cm(-2), and Cu = 4 x 10(12) atoms cm(-2) was observed on the as-received CdZnTe wafers. CdZnTe particulates and residual SiO2 polishing grit were observed on the surface of the as-received (112)B CdZnTe substrates. The polishing grit/CdZnTe particulate density on CdZnTe wafers was observed to vary across a 6 cm x 6 cm wafer from similar to 4 x 10(7) cm(-2) to 2.5 x 10(8) cm(-2). The surface impurity and damage layer of the (112)B CdZnTe wafers dictate that a molecular beam epitaxy (MBE) preparation etch is required. The contamination for one 4 cm x 4 cm and one 6 cm x 6 cm CdZnTe wafer after a standard MBE Br: methanol preparation etch procedure was also analyzed. A maximum surface impurity concentration of Al = 2.4 x 10(15) atoms cm(-2), Si = 4.0 x 10(13) atoms cm(-2), Cl = 7.5 x 10(13) atoms cm(-2), S = 4.4 x 10(13) atoms cm(-2), P = 9.8 x 10(13) atoms cm(-2), Fe = 1.0 x 10(13) atoms cm(-2), Br = 2.9 x 10(14) atoms cm(-2), and Cu = 5.2 x 10(12) atoms cm(-2) was observed on the MBE preparation-etched CdZnTe wafers. The MBE preparation-etched surface contamination consists of Cd(Zn)Te particles/flakes. No residual SiO2 polishing grit was observed on the (112)B surface. C1 [Benson, J. D.; Bubulac, L. O.; Jaime-Vasquez, M.; Lennon, C. M.; Arias, J. M.; Smith, P. J.; Jacobs, R. N.; Markunas, J. K.; Almeida, L. A.; Stoltz, A.] US Army RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. [Wijewarnasuriya, P. S.] US Army Res Lab, Adelphi, MD USA. [Peterson, J.; Reddy, M.; Jones, K.; Johnson, S. M.; Lofgreen, D. D.] Raytheon Vis Syst, Goleta, CA USA. RP Benson, JD (reprint author), US Army RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. EM david.j.benson@us.army.mil NR 13 TC 0 Z9 0 U1 6 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD SEP PY 2016 VL 45 IS 9 BP 4502 EP 4510 DI 10.1007/s11664-016-4642-y PG 9 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA DS9CM UT WOS:000381080000002 ER PT J AU Perera, AGU Lao, YF Wijewarnasuriya, PS Krishna, SS AF Perera, A. G. U. Lao, Y. F. Wijewarnasuriya, P. S. Krishna, S. S. TI Band Offsets of III-V and II-VI Materials Studied by Temperature-Dependent Internal Photoemission Spectroscopy SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE Heterojunction; internal photoemission; III-V; II-VI ID SEMICONDUCTOR AB The band offset at the interface of a heterojunction is one of the most important parameters determining the characteristics of devices constructed from heterojunction. Accurate knowledge of band offsets and their temperature dependence will allow one to simulate and predict the device performances. We present a temperature-dependent internal-photoemission spectroscopy (TDIPS) for studying the band offsets. Applications of the TDIPS into III-V and II-VI materials are discussed. C1 [Perera, A. G. U.; Lao, Y. F.] Georgia State Univ, Dept Phys & Astron, Atlanta, GA 30303 USA. [Wijewarnasuriya, P. S.] US Army Res Lab, Adelphi, MD 20783 USA. [Krishna, S. S.] Univ New Mexico, Dept Elect & Comp Engn, Ctr High Technol Mat, Albuquerque, NM 87106 USA. RP Perera, AGU (reprint author), Georgia State Univ, Dept Phys & Astron, Atlanta, GA 30303 USA. EM uperera@gsu.edu NR 20 TC 0 Z9 0 U1 3 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD SEP PY 2016 VL 45 IS 9 BP 4626 EP 4630 DI 10.1007/s11664-016-4729-5 PG 5 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA DS9CM UT WOS:000381080000019 ER PT J AU Schuster, J Dewames, RE Decuir, EA Bellotti, E Dhar, N Wijewarnasuriya, PS AF Schuster, J. Dewames, R. E. Decuir, E. A., Jr. Bellotti, E. Dhar, N. Wijewarnasuriya, P. S. TI Numerical Device Modeling, Analysis, and Optimization of Extended-SWIR HgCdTe Infrared Detectors SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE HgCdTe; eSWIR; infrared detectors; heterojunction; numerical simulations; Shockley-Read-Hall ID HETEROJUNCTIONS; LIFETIME; JUNCTION AB Imaging in the extended short-wavelength infrared (eSWIR) spectral band (1.7-3.0 mu m) for astronomy applications is an area of significant interest. However, these applications require infrared detectors with extremely low dark current (less than 0.01 electrons per pixel per second for certain applications). In these detectors, sources of dark current that may limit the overall system performance are fundamental and/or defect-related mechanisms. Non-optimized growth/device processing may present material point defects within the HgCdTe bandgap leading to Shockley-Read-Hall dominated dark current. While realizing contributions to the dark current from only fundamental mechanisms should be the goal for attaining optimal device performance, it may not be readily feasible with current technology and/or resources. In this regard, the U.S. Army Research Laboratory performed physics-based, two- and three-dimensional numerical modeling of HgCdTe photovoltaic infrared detectors designed for operation in the eSWIR spectral band. The underlying impetus for this capability and study originates with a desire to reach fundamental performance limits via intelligent device design. C1 [Schuster, J.; Decuir, E. A., Jr.; Wijewarnasuriya, P. S.] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Schuster, J.; Bellotti, E.] Boston Univ, Dept Elect & Comp Engn, 8 St Marys St, Boston, MA 02215 USA. [Dewames, R. E.] Fulcrum Co, 5870 Trinity Pkwy,Suite 400, Centreville, VA 20120 USA. [Dhar, N.] US Night Vis Elect Sensing Directorate, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. RP Schuster, J (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.; Schuster, J (reprint author), Boston Univ, Dept Elect & Comp Engn, 8 St Marys St, Boston, MA 02215 USA. EM js382@bu.edu OI Schuster, Jonathan/0000-0002-0835-5733 NR 25 TC 0 Z9 0 U1 2 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD SEP PY 2016 VL 45 IS 9 BP 4654 EP 4662 DI 10.1007/s11664-016-4602-6 PG 9 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA DS9CM UT WOS:000381080000023 ER PT J AU Simingalam, S Pattison, J Chen, YP Wijewarnasuriya, P Rao, MV AF Simingalam, Sina Pattison, James Chen, Yuanping Wijewarnasuriya, Priyalal Rao, Mulpuri V. TI Dislocation Reduction in HgCdTe Mesa Structures Formed on CdTe/Si SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE HgCdTe; annealing; mesa; dislocation; silicon ID DENSITY; LAYERS AB Mercury cadmium telluride (MCT) epilayers have been grown on CdTe/Si using molecular beam epitaxy and 8-mu m-deep mesa structures formed using plasma etching. Following previous work done on etching mesas and subjecting material to thermal cycle annealing, we set out to determine the limits and underlying physics of dislocation reduction in mesa-etched and annealed MCT. This paper describes the dependence of dislocation reduction on anneal time, cycle annealing, temperature, and etch depth. We show dislocation density reduction below 3 9 10 5 cm(-2) in 10-mu m-wide, long-bar mesas along the [0 (1) over bar1] orientation with only a 5-min anneal at 400 degrees C. C1 [Simingalam, Sina] George Mason Univ, Sch Phys Astron & Computat Sci, Fairfax, VA 22030 USA. [Simingalam, Sina; Pattison, James; Chen, Yuanping; Wijewarnasuriya, Priyalal] US Army Res Lab, Adelphi, MD 20783 USA. [Pattison, James] Univ Maryland, College Pk, MD 20742 USA. [Rao, Mulpuri V.] George Mason Univ, Elect & Computat Engn Dept, Fairfax, VA 22030 USA. RP Simingalam, S (reprint author), George Mason Univ, Sch Phys Astron & Computat Sci, Fairfax, VA 22030 USA.; Simingalam, S (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM ssiminga@gmu.edu NR 12 TC 0 Z9 0 U1 3 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD SEP PY 2016 VL 45 IS 9 BP 4668 EP 4673 DI 10.1007/s11664-016-4544-z PG 6 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA DS9CM UT WOS:000381080000025 ER PT J AU Murray, KS Ehdaie, B Musser, J Mashni, J Srimathveeravalli, G Durack, JC Solomon, SB Coleman, JA AF Murray, Katie S. Ehdaie, Behfar Musser, John Mashni, Joseph Srimathveeravalli, Govindarajan Durack, Jeremy C. Solomon, Stephen B. Coleman, Jonathan A. TI Pilot Study to Assess Safety and Clinical Outcomes of Irreversible Electroporation for Partial Gland Ablation in Men with Prostate Cancer SO JOURNAL OF UROLOGY LA English DT Article DE ablation techniques; electroporation; organ sparing treatments; quality of life ID FOCAL THERAPY; RADICAL PROSTATECTOMY; FUNCTIONAL RECOVERY; FEASIBILITY; TRIAL; CONSENSUS; EFFICACY; TISSUE; MODEL; WILL AB Purpose: Partial prostate gland ablation is a strategy to manage localized prostate cancer. Irreversible electroporation can ablate localized soft tissues. We describe 30 and 90-day complications and intermediate term functional outcomes in men undergoing prostate gland ablation using irreversible electroporation. Materials and Methods: We reviewed the charts of 25 patients with prostate cancer who underwent prostate gland ablation using irreversible electroporation as a primary procedure and who were followed for at least 6 months. Results: Median followup was 10.9 months. Grade 3 complications occurred in 2 patients including epididymitis (1) and urinary tract infection (1). Fourteen patients experienced grade 2 or lower complications, mainly transient urinary symptoms, hematuria and urinary tract infections. Of 25 patients 4 (16%) had cancer in the zone of ablation on routine followup biopsy at 6 months. Of those with normal urinary function at baseline 88% and 94% reported normal urinary function at 6 and 12 months after prostate gland ablation, respectively. By 12 months only 1 patient with normal erectile function at baseline reported new difficulty with potency and only 2 patients (8%) required a pad for urinary incontinence. Conclusions: Prostate gland ablation with irreversible electroporation is feasible and safe in selected men with localized prostate cancer. Intermediate term urinary and erectile function outcomes appear reasonable. Irreversible electroporation is effective in the ablation of tumor bearing prostate tissue as a majority of men had no evidence of residual cancer on biopsy 6 months after prostate gland ablation. C1 [Murray, Katie S.; Ehdaie, Behfar; Coleman, Jonathan A.] Mem Sloan Kettering Canc Ctr, Dept Surg, Urol Serv, 1275 York Ave, New York, NY 10065 USA. [Srimathveeravalli, Govindarajan] Mem Sloan Kettering Canc Ctr, Radiochem & Imaging Sci Serv, Dept Radiol, 1275 York Ave, New York, NY 10021 USA. [Srimathveeravalli, Govindarajan] Mem Sloan Kettering Canc Ctr, Dept Med Phys, New York, NY 10021 USA. [Durack, Jeremy C.; Solomon, Stephen B.] Mem Sloan Kettering Canc Ctr, Intervent Radiol Serv, Dept Radiol, New York, NY 10021 USA. [Ehdaie, Behfar; Srimathveeravalli, Govindarajan; Solomon, Stephen B.; Coleman, Jonathan A.] Weill Cornell Med Coll, New York, NY USA. [Musser, John] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. [Mashni, Joseph] Banner MD Anderson Canc Ctr, Dept Surg Oncol, Gilbert, AZ USA. RP Coleman, JA (reprint author), Mem Sloan Kettering Canc Ctr, Dept Surg, Urol Serv, 1275 York Ave, New York, NY 10065 USA. EM colemanj@mskcc.org FU Sidney Kimmel Center for Prostate and Urologic Cancers; NIH/NCI Cancer Center Support Grant [P30 CA008748] FX Supported by the Sidney Kimmel Center for Prostate and Urologic Cancers, NIH/NCI Cancer Center Support Grant P30 CA008748, and by David H. Koch through the Prostate Cancer Foundation. NR 28 TC 2 Z9 2 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-5347 EI 1527-3792 J9 J UROLOGY JI J. Urol. PD SEP PY 2016 VL 196 IS 3 BP 883 EP 889 DI 10.1016/j.juro.2016.02.2986 PG 7 WC Urology & Nephrology SC Urology & Nephrology GA DT1WF UT WOS:000381272100098 PM 27113966 ER PT J AU Souhan, B Chen, CP Lu, M Stein, A Bakhru, H Grote, RR Bergman, K Green, WMJ Osgood, RM AF Souhan, Brian Chen, Christine P. Lu, Ming Stein, Aaron Bakhru, Hassaram Grote, Richard R. Bergman, Keren Green, William M. J. Osgood, Richard M., Jr. TI Ar+-Implanted Si-Waveguide Photodiodes for Mid-Infrared Detection SO PHOTONICS LA English DT Article DE silicon; photodetectors; integrated optics devices ID ERROR-FREE OPERATION; MU-M; INFRARED PHOTODIODES; AVALANCHE PHOTODIODE; SILICON; PHOTODETECTORS; MODULATION; BANDWIDTH; MODE; BAND AB Complementary metal-oxide-semiconductor (CMOS)-compatible Ar+-implanted Si-waveguide p-i-n photodetectors operating in the mid-infrared (2.2 to 2.3 mu m wavelengths) are demonstrated at room temperature. Responsivities exceeding 21 mA/ W are measured at a 5 V reverse bias with an estimated internal quantum efficiency of 3.1%-3.7%. The dark current is found to vary from a few nanoamps down to less than 11 pA after post-implantation annealing at 350 degrees C. Linearity is demonstrated over four orders of magnitude, confirming a single-photon absorption process. The devices demonstrate a higher thermal processing budget than similar Si+-implanted devices and achieve higher responsivity after annealing up to 350 degrees C. C1 [Souhan, Brian] US Mil Acad, Photon Res Ctr, West Point, NY 10996 USA. [Chen, Christine P.; Bergman, Keren] Columbia Univ, Dept Elect Engn, 500 W 120th St, New York, NY 10027 USA. [Lu, Ming; Stein, Aaron] Brookhaven Natl Lab, Ctr Funct Nanomat, POB 5000, Upton, NY 11973 USA. [Bakhru, Hassaram] SUNYPOLY, Coll Nanoscale Sci & Engn, Albany, NY 12203 USA. [Grote, Richard R.] Univ Penn, Dept Elect & Syst Engn, 200 S 33rd St, Philadelphia, PA 19104 USA. [Green, William M. J.] IBM TJ Watson Res Ctr, 1101 Kitchawan Rd, Yorktown Hts, NY 10598 USA. [Osgood, Richard M., Jr.] Columbia Univ, Microelect Sci Labs, 500 W 120th St, New York, NY 10027 USA. RP Souhan, B (reprint author), US Mil Acad, Photon Res Ctr, West Point, NY 10996 USA. EM brian.souhan@gmail.com; cpc2143@columbia.edu; mlu@bnl.gov; stein@bnl.gov; hbakhru@sunypoly.edu; rgrote@seas.upenn.edu; bergman@ee.columbia.edu; wgreen@us.ibm.com; osgood@columbia.edu NR 27 TC 0 Z9 0 U1 7 U2 7 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 2304-6732 J9 PHOTONICS JI Photonics PD SEP PY 2016 VL 3 IS 3 AR 46 DI 10.3390/photonics3030046 PG 8 WC Optics SC Optics GA DT9ZG UT WOS:000381860400006 ER PT J AU Walsh, DV Jurek, GM McLean, WE Statz, JK Allen, RL Riggs, DW AF Walsh, David V. Jurek, Gina M. McLean, William E. Statz, Jonathan K. Allen, Roddricus L. Riggs, Daniel W. TI Assessment of a Prototype Apache Flight Eyewear SO AEROSPACE MEDICINE AND HUMAN PERFORMANCE LA English DT Article DE modified HGU-4/P Apache spectacles; field of view; helmet display unit; military; vision correction ID AIRCREW EYEWEAR; ARMY AIRCREW AB BACKGROUND: Apache pilots needing refractive correction are issued modified HGU-4/P aviator spectacles. However, a recently published survey found field of view (FOV) dissatisfaction with the current spectacles when sighting in with a Helmet Display Unit (HDU). A current Air Force flight frame was modified in-lab and the purpose of this study was to evaluate the FOV with the current Apache flight frame vs. the modified flight frame. METHODS: Recruited were 21 Apache pilots to assess FOV under three conditions: 1) wearing the current Apache frame; 2) wearing the modified Apache frame; and 3) wearing no frame. The main outcome measure was total FOV of four quadrants tested: superior left (45); superior right (135); inferior right (225); and inferior left (3150). RESULTS: No significant differences in FOV were seen between the two frames tested while wearing the current Apache helmet (P = 0.33) and the new Apache helmet (P = 0.64). However, there were significant differences in FOV between the no frame condition and the two frame conditions tested with both helmets (P < 0.001). DISCUSSION: No significant differences in FOV were seen between the two frames tested while wearing either Apache helmet. However, with both helmets there were significant differences in FOV between the no frame condition and the two frame conditions tested. This suggests that wearing no eyewear is still optimal in integrating the HDU device. With advances in contact lens technology, future research can study the viability of the latest generation of multifocal contact lenses with Apache aviators. C1 [Walsh, David V.; Jurek, Gina M.; McLean, William E.; Statz, Jonathan K.; Allen, Roddricus L.; Riggs, Daniel W.] US Army, Aeromed Res Lab, Ft Rucker, AL USA. RP Walsh, DV (reprint author), US Army, Aeromed Res Lab, Vis Protect & Performance Div, 6901 Farrel Rd, Ft Rucker, AL 36362 USA. EM david.v.walsh.mil@mail.mil FU Postgraduate Research Participation Program at the U.S. Army Aeromedical Research Laboratory; U.S. Army Medical Research and Material Command FX This research was sponsored in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Aeromedical Research Laboratory administered by the Oak Ridge Institute of Science and Education through an interagency agreement the U.S. Department of Energy and U.S. Army Medical Research and Material Command. NR 12 TC 0 Z9 0 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 2375-6314 EI 2375-6322 J9 AEROSP MED HUM PERF JI Aerosp. Med.Hum. Perform. PD SEP PY 2016 VL 87 IS 9 BP 800 EP 805 DI 10.3357/AMHP.4581.2016 PG 6 WC Biophysics; Public, Environmental & Occupational Health; Medicine, Research & Experimental SC Biophysics; Public, Environmental & Occupational Health; Research & Experimental Medicine GA DT8XA UT WOS:000381777800006 PM 27634700 ER PT J AU Te, JA AbdulHameed, MDM Wallqvist, A AF Te, Jerez A. AbdulHameed, Mohamed Diwan M. Wallqvist, Anders TI Systems toxicology of chemically induced liver and kidney injuries: histopathology-associated gene co-expression modules SO JOURNAL OF APPLIED TOXICOLOGY LA English DT Article DE co-expression modules; toxicogenomics; systems toxicology; nephrotoxicity; hepatotoxicity; histopathology; adverse outcome pathways ID DRUG DISCOVERY; FIBROSIS; TOXICOGENOMICS; RATS; ORGANIZATION; PHARMACOLOGY; MECHANISMS; EXPRESSION; BIOMARKERS; DATABASE AB Organ injuries caused by environmental chemical exposures or use of pharmaceutical drugs pose a serious health risk that may be difficult to assess because of a lack of non-invasive diagnostic tests. Mapping chemical injuries to organ-specific histopathology outcomes via biomarkers will provide a foundation for designing precise and robust diagnostic tests. We identified co-expressed genes (modules) specific to injury endpoints using the Open Toxicogenomics Project-Genomics Assisted Toxicity Evaluation System (TG-GATEs) - a toxicogenomics database containing organ-specific gene expression data matched to dose- and time-dependent chemical exposures and adverse histopathology assessments in Sprague-Dawley rats. We proposed a protocol for selecting gene modules associated with chemical-induced injuries that classify 11 liver and eight kidney histopathology endpoints based on dose-dependent activation of the identified modules. We showed that the activation of the modules for a particular chemical exposure condition, i.e., chemical-time-dose combination, correlated with the severity of histopathological damage in a dose-dependent manner. Furthermore, the modules could distinguish different types of injuries caused by chemical exposures as well as determine whether the injury module activation was specific to the tissue of origin (liver and kidney). The generated modules provide a link between toxic chemical exposures, different molecular initiating events among underlying molecular pathways and resultant organ damage. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. Journal of Applied Toxicology published by John Wiley & Sons, Ltd. We proposed a protocol for selecting gene co-expression modules associated with chemical-induced injuries that classify 11 liver and eight kidney histopathology endpoints based on dose-dependent activation of the identified modules. We showed that the activation of the modules for a particular chemical exposure correlated with the severity of histopathological damage and could distinguish different types of organ-specific injuries. The generated modules provide a link between toxic chemical exposures, different molecular initiating events among underlying molecular pathways, and resultant organ damage. C1 [Te, Jerez A.; AbdulHameed, Mohamed Diwan M.; Wallqvist, Anders] US Army, Med Res & Mat Command, High Performance Comp Software Applicat Inst, Dept Def Biotechnol,Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. RP Wallqvist, A (reprint author), ATTN MCMR TT, 504 Scott St, Ft Detrick, MD 21702 USA. EM sven.a.wallqvist.civ@mail.mil FU U.S. Army Medical Research and Materiel Command (Fort Detrick, MD) as part of the U.S. Army's Network Science Initiative; Defense Threat Reduction Agency [CBCall14-CBS-05-2-0007] FX The authors were supported by the U.S. Army Medical Research and Materiel Command (Fort Detrick, MD) as part of the U.S. Army's Network Science Initiative, and by the Defense Threat Reduction Agency grant CBCall14-CBS-05-2-0007. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or of the U.S. Department of Defense. This paper has been approved for public release with unlimited distribution. NR 37 TC 1 Z9 1 U1 7 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0260-437X EI 1099-1263 J9 J APPL TOXICOL JI J. Appl. Toxicol. PD SEP PY 2016 VL 36 IS 9 BP 1137 EP 1149 DI 10.1002/jat.3278 PG 13 WC Toxicology SC Toxicology GA DR5PD UT WOS:000379954000007 PM 26725466 ER PT J AU Li, XM Huang, J Zhang, M Funakoshi, R Sheetij, D Spaccapelo, R Crisanti, A Nussenzweig, V Nussenzweig, RS Tsuji, M AF Li, Xiangming Huang, Jing Zhang, Min Funakoshi, Ryota Sheetij, Dutta Spaccapelo, Roberta Crisanti, Andrea Nussenzweig, Victor Nussenzweig, Ruth S. Tsuji, Moriya TI Human CD8+T cells mediate protective immunity induced by a human malaria vaccine in human immune system mice SO VACCINE LA English DT Article DE Human CD8+T cell; Human immune system mice; Protection; Malaria; Recombinant adenovirus ID FALCIPARUM CIRCUMSPOROZOITE PROTEIN; CYTOTOXIC T-LYMPHOCYTES; PLASMODIUM-FALCIPARUM; SPOROZOITES; IMMUNIZATION; ADENOVIRUS; EPITOPE; BERGHEI; YOELII; CLONES AB A number of studies have shown that CD8+ T cells mediate protective anti-malaria immunity in a mouse model. However, whether human CD8+ T cells play a role in protection against malaria remains unknown. We recently established human immune system (HIS) mice harboring functional human CD8+ T cells (HIS-CD8 mice) by transduction with HLA-A*0201 and certain human cytokines using recombinant adeno-associated virus-based gene transfer technologies. These HIS-CD8 mice mount a potent, antigen-specific HLA-A*0201-restricted human CD8+ T-cell response upon immunization with a recombinant adenovirus expressing a human malaria antigen, the Plasmodium falciparum circumsporozoite protein (PfCSP), termed AdPfCSP. In the present study, we challenged AdPfCSP-immunized HIS-CD8 mice with transgenic Plasmodium berghei sporozoites expressing full-length PfCSP and found that AdPfCSP-immunized (but not naive) mice were protected against subsequent malaria challenge. The level of the HLA-A*0201-restricted, PfCSP-specific human CD8+ T-cell response was closely correlated with the level of malaria protection. Furthermore, depletion of human CD8+ T cells from AdPfCSP-immunized HIS-CD8 mice almost completely abolished the anti -malaria immune response. Taken together, our data show that human CD8+ T cells mediate protective anti-malaria immunity in vivo. (C) 2016 The Author(s). Published by Elsevier Ltd. C1 [Li, Xiangming; Huang, Jing; Zhang, Min; Funakoshi, Ryota; Tsuji, Moriya] Rockefeller Univ, Aaron Diamond AIDS Res Ctr, HIV & Malaria Vaccine Program, 455 First Ave, New York, NY 10016 USA. [Zhang, Min; Nussenzweig, Victor; Nussenzweig, Ruth S.] NYU, Sch Med, Dept Pathol, 550 First Ave, New York, NY 10016 USA. [Sheetij, Dutta] Walter Reed Army Inst Res, Malaria Vaccine Dev Branch, Silver Spring, MD USA. [Spaccapelo, Roberta] Univ Perugia, Perugia, Italy. [Crisanti, Andrea] Imperial Coll London, London, England. [Nussenzweig, Ruth S.] NYU, Sch Med, Dept Microbiol, Div Parasitol, New York, NY 10016 USA. RP Tsuji, M (reprint author), Rockefeller Univ, Aaron Diamond AIDS Res Ctr, HIV & Malaria Vaccine Program, 455 First Ave, New York, NY 10016 USA. EM mtsuji@adarc.org RI Zhang, Min/G-4480-2011; OI Zhang, Min/0000-0001-9794-4523; Tsuji, Moriya/0000-0001-8587-277X FU Grand Challenges Exploration grant from the Gates Foundation [OPP1007283 GCE]; Mark S. Bertuch AIDS Research Fund FX This work was supported by a Grand Challenges Exploration grant (OPP1007283 GCE) from the Gates Foundation and by grants from the Mark S. Bertuch AIDS Research Fund. NR 33 TC 1 Z9 1 U1 4 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD AUG 31 PY 2016 VL 34 IS 38 BP 4501 EP 4506 DI 10.1016/j.vaccine.2016.08.006 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA DV5XU UT WOS:000383004800010 PM 27502569 ER PT J AU Woo, HJ Yu, CG Kumar, K Gold, B Reifman, J AF Woo, Hyung Jun Yu, Chenggang Kumar, Kamal Gold, Bert Reifman, Jaques TI Genotype distribution-based inference of collective effects in genome-wide association studies: insights to age-related macular degeneration disease mechanism SO BMC GENOMICS LA English DT Article DE Genome-wide association; Machine learning; Epistasis; Single-nucleotide polymorphism; Age-related macular degeneration ID COMPLEMENT FACTOR-H; PENALIZED LOGISTIC-REGRESSION; DISCRIMINANT-ANALYSIS; VARIABLE SELECTION; GENE INTERACTIONS; CANDIDATE GENE; BREAST-CANCER; SUSCEPTIBILITY; EPISTASIS; APOPTOSIS AB Background: Genome-wide association studies provide important insights to the genetic component of disease risks. However, an existing challenge is how to incorporate collective effects of interactions beyond the level of independent single nucleotide polymorphism (SNP) tests. While methods considering each SNP pair separately have provided insights, a large portion of expected heritability may reside in higher-order interaction effects. Results: We describe an inference approach (discrete discriminant analysis; DDA) designed to probe collective interactions while treating both genotypes and phenotypes as random variables. The genotype distributions in case and control groups are modeled separately based on empirical allele frequency and covariance data, whose differences yield disease risk parameters. We compared pairwise tests and collective inference methods, the latter based both on DDA and logistic regression. Analyses using simulated data demonstrated that significantly higher sensitivity and specificity can be achieved with collective inference in comparison to pairwise tests, and with DDA in comparison to logistic regression. Using age-related macular degeneration (AMD) data, we demonstrated two possible applications of DDA. In the first application, a genome-wide SNP set is reduced into a small number (similar to 100) of variants via filtering and SNP pairs with significant interactions are identified. We found that interactions between SNPs with highest AMD association were epigenetically active in the liver, adipocytes, and mesenchymal stem cells. In the other application, multiple groups of SNPs were formed from the genome-wide data and their relative strengths of association were compared using cross-validation. This analysis allowed us to discover novel collections of loci for which interactions between SNPs play significant roles in their disease association. In particular, we considered pathway-based groups of SNPs containing up to similar to 10,000 variants in each group. In addition to pathways related to complement activation, our collective inference pointed to pathway groups involved in phospholipid synthesis, oxidative stress, and apoptosis, consistent with the AMD pathogenesis mechanism where the dysfunction of retinal pigment epithelium cells plays central roles. Conclusions: The simultaneous inference of collective interaction effects within a set of SNPs has the potential to reveal novel aspects of disease association. C1 [Woo, Hyung Jun; Yu, Chenggang; Kumar, Kamal; Reifman, Jaques] US Army Med Res & Mat Command, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. [Gold, Bert] NCI, Lab Genom Div, Frederick, MD 21701 USA. RP Reifman, J (reprint author), US Army Med Res & Mat Command, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. EM jaques.reifman.civ@mail.mil OI Kumar, Kamal/0000-0002-9470-6682 FU U.S. Army Medical Research and Materiel Command (Ft. Detrick, Maryland) FX This work was supported by the U.S. Army Medical Research and Materiel Command (Ft. Detrick, Maryland). The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or of the U.S. Department of Defense. This paper has been approved for public release with unlimited distribution. NR 71 TC 1 Z9 1 U1 3 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2164 J9 BMC GENOMICS JI BMC Genomics PD AUG 30 PY 2016 VL 17 AR 695 DI 10.1186/s12864-016-2871-3 PG 20 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA DY3HG UT WOS:000384980800009 PM 27576376 ER PT J AU Childs, JD Fritz, JM Wu, SS Flynn, TW Wainner, RS Robertson, EK Kim, FS George, SZ AF Childs, John D. Fritz, Julie M. Wu, Samuel S. Flynn, Timothy W. Wainner, Robert S. Robertson, Eric K. Kim, Forest S. George, Steven Z. TI Implications of early and guideline adherent physical therapy for low back pain on utilization and costs (vol 15, 150, 2015) SO BMC HEALTH SERVICES RESEARCH LA English DT Correction C1 [Childs, John D.] Baylor Univ, US Army, Army Med Dept Ctr & Sch, Doctoral Program Phys Therapy,JBSA Ft Sam Houston, 3151 Scott Rd,Rm 2307, San Antonio, TX 78234 USA. [Fritz, Julie M.] Univ Utah, Dept Phys Therapy, 520 Wakara Way, Salt Lake City, UT 84108 USA. [Wu, Samuel S.] Univ Florida, Coll Publ Hlth & Hlth Profess, Dept Hlth Serv Res Management & Policy, 1329 SW 16th St,Rm 5231, Gainesville, FL 32610 USA. [Flynn, Timothy W.; Wainner, Robert S.] South Coll, EIM Sch Phys Therapy, 3904 Lonas Dr, Knoxville, TN 37909 USA. [Robertson, Eric K.] Univ Texas El Paso, Doctor Phys Therapy Program, 500 W Univ Ave, El Paso, TX 79968 USA. [Kim, Forest S.] US Army, Med Dept Ctr & Sch, Baylor MHA MBA Program, JBSA Ft Sam Houston, 3599 Winfield Scott Rd,Bldg 2841, San Antonio, TX 78234 USA. [George, Steven Z.] Univ Florida, Brooks PHHP Res Collaborat, Dept Phys Therapy, POB 100154, Gainesville, FL 32610 USA. RP Childs, JD (reprint author), Baylor Univ, US Army, Army Med Dept Ctr & Sch, Doctoral Program Phys Therapy,JBSA Ft Sam Houston, 3151 Scott Rd,Rm 2307, San Antonio, TX 78234 USA. EM childsjd@gmail.com NR 2 TC 0 Z9 0 U1 6 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1472-6963 J9 BMC HEALTH SERV RES JI BMC Health Serv. Res. PD AUG 26 PY 2016 VL 16 AR 444 DI 10.1186/s12913-016-1681-2 PG 1 WC Health Care Sciences & Services SC Health Care Sciences & Services GA DU8ES UT WOS:000382446700001 ER PT J AU Manandhar, E Maslamani, N Petrikovics, I Rockwood, GA Logue, BA AF Manandhar, Erica Maslamani, Nujud Petrikovics, Ilona Rockwood, Gary A. Logue, Brian A. TI Determination of dimethyl trisulfide in rabbit blood using stir bar sorptive extraction gas chromatography-mass spectrometry SO JOURNAL OF CHROMATOGRAPHY A LA English DT Article DE Cyanide; Dimethyl trisulfide; Antidote; Stir bar sorptive extraction; Gas chromatography mass spectrometry ID SOLID-PHASE MICROEXTRACTION; VOLATILE SULFUR-COMPOUNDS; FLAME PHOTOMETRIC DETECTION; ANTIDOTE TREATMENT; CYANIDE; PLASMA; HYDROXOCOBALAMIN; MODEL; THIOCYANATE; THIOSULFATE AB Cyanide poisoning by accidental or intentional exposure poses a severe health risk. The current Food and Drug Administration approved antidotes for cyanide poisoning can be effective, but each suffers from specific major limitations concerning large effective dosage, delayed onset of action, or dependence on enzymes generally confined to specific organs. Dimethyl trisulfide (DMTS), a sulfur donor that detoxifies cyanide by converting it into thiocyanate (a relatively nontoxic cyanide metabolite), is a promising next generation cyanide antidote. Although a validated analytical method to analyze DMTS from any matrix is not currently available, one will be vital for the approval of DMTS as a therapeutic agent against cyanide poisoning. Hence, a stir bar sorptive extraction (SBSE) gas chromatography mass spectrometry (GC MS) method was developed and validated for the analysis of DMTS from rabbit whole blood. Following acid denaturation of blood, DMTS was extracted into a polydimethylsiloxane-coated stir bar. The DMTS was then thermally desorbed from the stir bar and analyzed by GC MS. The limit of detection of DMTS using this method was 0.06 mu M with dynamic range from 0.5-100 mu M. For quality control standards, the precision, as measured by percent relative standard deviation, was below 10%, and the accuracy was within 15% of the nominal concentration. The method described here will allow further investigations of DMTS as a promising antidote for cyanide poisoning. (c) 2016 Elsevier B.V. All rights reserved. C1 [Manandhar, Erica; Maslamani, Nujud; Logue, Brian A.] South Dakota State Univ, Dept Chem & Biochem, Avera Hlth & Sci, Box 2202, Brookings, SD 57007 USA. [Petrikovics, Ilona] Sam Houston State Univ, Dept Chem, POB 2117, Huntsville, TX 77341 USA. [Rockwood, Gary A.] US Army, Analyt Toxicol Div, Med Res Inst Chem Def, 2900 Rickets Point Rd, Aberdeen Proving Ground, MD 21010 USA. RP Logue, BA (reprint author), South Dakota State Univ, Dept Chem & Biochem, Avera Hlth & Sci, Box 2202, Brookings, SD 57007 USA. EM brian.logue@sdstate.edu OI Logue, Brian/0000-0002-2400-9339 FU Counter ACT Program; National Institutes Of Health Office of the Director; National Institute of Allergy and Infectious Diseases [Y1-OD-0690-01/AOD14020-001-00000/A120- B.P2014-01]; U.S. Joint Executive Office for Chem Bio Defense, Joint Program Management Protection [W911SR-09-0059] FX We gratefully acknowledge the support from the Counter ACT Program, National Institutes Of Health Office of the Director, and the National Institute of Allergy and Infectious Diseases, Interagency Agreement Numbers Y1-OD-0690-01/AOD14020-001-00000/A120- B.P2014-01. We would also like to acknowledge U.S. Joint Executive Office for Chem Bio Defense, Joint Program Management Protection Contract W911SR-09-0059 for funding the GC-MS instrument. Furthermore, the authors are thankful to Wenhui Zhou, a former graduate student at South Dakota State University for her assistance in preliminary phases of GC-MS method development. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the US Army, the National Institutes of Health or the CounterACT Program. NR 50 TC 1 Z9 1 U1 14 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0021-9673 EI 1873-3778 J9 J CHROMATOGR A JI J. Chromatogr. A PD AUG 26 PY 2016 VL 1461 BP 10 EP 17 DI 10.1016/j.chroma.2016.07.046 PG 8 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA DT9RO UT WOS:000381840200002 PM 27477518 ER PT J AU Larocca, RA Abbink, P Peron, JPS Zanotto, PMD Iampietro, MJ Badamchi-Zadeh, A Boyd, M Ng'ang'a, D Kirilova, M Nityanandam, R Mercado, NB Li, ZF Moseley, ET Bricault, CA Borducchi, EN Giglio, PB Jetton, D Neubauer, G Nkolola, JP Maxfield, LF De La Barrera, RA Jarman, RG Eckels, KH Michael, NL Thomas, SJ Barouch, DH AF Larocca, Rafael A. Abbink, Peter Peron, Jean Pierre S. Zanotto, Paolo M. de A. Iampietro, M. Justin Badamchi-Zadeh, Alexander Boyd, Michael Ng'ang'a, David Kirilova, Marinela Nityanandam, Ramya Mercado, Noe B. Li, Zhenfeng Moseley, Edward T. Bricault, Christine A. Borducchi, Erica N. Giglio, Patricia B. Jetton, David Neubauer, George Nkolola, Joseph P. Maxfield, Lori F. De La Barrera, Rafael A. Jarman, Richard G. Eckels, Kenneth H. Michael, Nelson L. Thomas, Stephen J. Barouch, Dan H. TI Vaccine protection against Zika virus from Brazil SO NATURE LA English DT Article ID PHASE-1 CLINICAL-TRIAL; HEALTHY-ADULTS; NEUTRALIZING ANTIBODY; JAPANESE ENCEPHALITIS; CHALLENGE; MICE; IMMUNOGENICITY; ORGANOIDS; INFECTION; AMERICA AB Zika virus (ZIKV) is a flavivirus that is responsible for the current epidemic in Brazil and the Americas(1,2). ZIKV has been causally associated with fetal microcephaly, intrauterine growth restriction, and other birth defects in both humans(3-8) and mice(9-11). The rapid development of a safe and effective ZIKV vaccine is a global health priority(1,2), but very little is currently known about ZIKV immunology and mechanisms of immune protection. Here we show that a single immunization with a plasmid DNA vaccine or a purified inactivated virus vaccine provides complete protection in susceptible mice against challenge with a strain of ZIKV involved in the outbreak in northeast Brazil. This ZIKV strain has recently been shown to cross the placenta and to induce fetal microcephaly and other congenital malformations in mice(11). We produced DNA vaccines expressing ZIKV pre-membrane and envelope (prM-Env), as well as a series of deletion mutants. The prM-Env DNA vaccine, but not the deletion mutants, afforded complete protection against ZIKV, as measured by absence of detectable viraemia following challenge, and protective efficacy correlated with Env-specific antibody titers. Adoptive transfer of purified IgG from vaccinated mice conferred passive protection, and depletion of CD4 and CD8 T lymphocytes in vaccinated mice did not abrogate this protection. These data demonstrate that protection against ZIKV challenge can be achieved by single-shot subunit and inactivated virus vaccines in mice and that Env-specific antibody titers represent key immunologic correlates of protection. Our findings suggest that the development of a ZIKV vaccine for humans is likely to be achievable. C1 [Larocca, Rafael A.; Abbink, Peter; Iampietro, M. Justin; Badamchi-Zadeh, Alexander; Boyd, Michael; Ng'ang'a, David; Kirilova, Marinela; Nityanandam, Ramya; Mercado, Noe B.; Li, Zhenfeng; Moseley, Edward T.; Bricault, Christine A.; Borducchi, Erica N.; Giglio, Patricia B.; Jetton, David; Neubauer, George; Nkolola, Joseph P.; Maxfield, Lori F.; Barouch, Dan H.] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02215 USA. [Peron, Jean Pierre S.; Zanotto, Paolo M. de A.] Univ Sao Paulo, BR-05508000 Sao Paulo, Brazil. [De La Barrera, Rafael A.; Jarman, Richard G.; Eckels, Kenneth H.; Michael, Nelson L.; Thomas, Stephen J.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Barouch, Dan H.] Ragon Inst MGH MIT & Harvard, Cambridge, MA 02139 USA. RP Barouch, DH (reprint author), Harvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02215 USA.; Barouch, DH (reprint author), Ragon Inst MGH MIT & Harvard, Cambridge, MA 02139 USA. EM dbarouch@bidmc.harvard.edu FU Ragon Institute of MGH, MIT, and Harvard; National Institutes of Health [AI095985, AI096040, AI100663, AI124377]; Sao Paulo Research Foundation [FAPESP 2011/18703-2, 2014/17766-9] FX We thank P. Vasconcelos, K. Modjarrad, R. Olson, K. Kabra, C. Kannadka, C. Springer, G. Ballarini, G. Alter, K. Stephenson, F. Stephens, B. Lee, J. Jimenez, A. Chandrashekar, P. Penaloza and C. Cabral for generous advice, assistance and reagents. We acknowledge support from the Ragon Institute of MGH, MIT, and Harvard, the National Institutes of Health (AI095985, AI096040, AI100663, AI124377), and the Sao Paulo Research Foundation (FAPESP 2011/18703-2, 2014/17766-9). The views expressed in this manuscript are those of the authors and do not represent the official views of the Department of the Army or the Department of Defense. NR 30 TC 27 Z9 31 U1 50 U2 52 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0028-0836 EI 1476-4687 J9 NATURE JI Nature PD AUG 25 PY 2016 VL 536 IS 7617 BP 474 EP + DI 10.1038/nature18952 PG 15 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DV0YL UT WOS:000382646600045 PM 27355570 ER PT J AU West, AL Schaeublin, NM Griep, MH Maurer-Gardner, EI Cole, DP Fakner, AM Hussain, SM Karna, SP AF West, Abby L. Schaeublin, Nicole M. Griep, Mark H. Maurer-Gardner, Elizabeth I. Cole, Daniel P. Fakner, Alexis M. Hussain, Saber M. Karna, Shashi P. TI In situ Synthesis of Fluorescent Gold Nanoclusters by Nontumorigenic Microglial Cells SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE in situ; gold nanocluster; neuronal-microglial; cell culture bioimaging ID HYDROGEN-PEROXIDE; METAL NANOCLUSTERS; TUMOR-CELLS; REDUCTION; CANCER; NANOPARTICLES; GLUTAMATE; BRAIN; NANOCRYSTALS; MONODISPERSE AB To date, the directed in situ synthesis of fluorescent gold nanoclusters (AuNCs) has only been demonstrated in cancerous cells, with the theorized synthesis mechanism prohibiting AuNC formation in nontumorigenic cell lines. This limitation hinders potential biostabilized AuNC-based technology in healthy cells involving both chemical and mechanical analysis, such as the direct sensing of protein function and the elucidation of local mechanical environments. Thus, new synthesis strategies are required to expand the application space of AuNCs beyond cancer-focused cellular studies. In this contribution, we have developed the methodology and demonstrated the direct in situ synthesis of AuNCs in the nontumorigenic neuronal microglial line, C8B4. The as-synthesized AuNCs form in situ and are stabilized by cellular proteins. The clusters exhibit bright green fluorescence and demonstrate low (<10%) toxicity. Interestingly, elevated ROS levels were not required for the in situ formation of AuNCs, although intracellular reductants such as glutamate were required for the synthesis of AuNCs in C8B4 cells. To our knowledge, this is the first-ever demonstration of AuNC synthesis in nontumorigenic cells and, as such, it considerably expands the application space of biostabilized fluorescent AuNCs. C1 [West, Abby L.; Griep, Mark H.; Fakner, Alexis M.; Karna, Shashi P.] US Army Res Lab, Composite & Hybrid Mat Branch, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Cole, Daniel P.] US Army Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA. [Schaeublin, Nicole M.; Maurer-Gardner, Elizabeth I.; Hussain, Saber M.] Air Force Res Lab, Mol Bioeffects Branch, Bioeffects Div, Human Effectiveness Directorate,Human Performance, Wright Patterson AFB, OH 45433 USA. RP West, AL; Karna, SP (reprint author), US Army Res Lab, Composite & Hybrid Mat Branch, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM abby.l.west.civ@mail.mil; shashi.p.karna.civ@mail.mil FU DoD Blast Injury Research Program Coordinating Office of the U.S. Army Medical Research and Materiel Command FX Part of the research performed at the Army Research Laboratory was supported by the DoD Blast Injury Research Program Coordinating Office of the U.S. Army Medical Research and Materiel Command. NR 36 TC 0 Z9 0 U1 21 U2 22 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD AUG 24 PY 2016 VL 8 IS 33 BP 21221 EP 21227 DI 10.1021/acsami.6b06624 PG 7 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA DU4JR UT WOS:000382179400012 PM 27328035 ER PT J AU Paronyan, L Zardaryan, E Bakunts, V Gevorgyan, Z Asoyan, V Apresyan, H Hovhannisyan, A Palayan, K Bautista, CT Kuchuloria, T Rivard, RG AF Paronyan, Lusine Zardaryan, Eduard Bakunts, Vahe Gevorgyan, Zaruhi Asoyan, Vigen Apresyan, Hripsime Hovhannisyan, Alvard Palayan, Karo Bautista, Christian T. Kuchuloria, Tinatin Rivard, Robert G. TI A retrospective chart review study to describe selected zoonotic and arboviral etiologies in hospitalized febrile patients in the Republic of Armenia SO BMC INFECTIOUS DISEASES LA English DT Review DE Armenia; Febrile; Zoonotic; Hospital; Epidemiology ID HUMAN BRUCELLOSIS; RISK-FACTORS; GEORGIA; EPIDEMIOLOGY; SURVEILLANCE; ILLNESS; COUNTRY AB Background: Scant information is available on the infectious causes of febrile illnesses in Armenia. The goal of this study was to describe the most common causes, with a focus on zoonotic and arboviral infections and related epidemiological and clinical patterns for hospitalized patients with febrile illnesses of infectious origin admitted to Nork Infectious Diseases Clinical Hospital, the referral center for infectious diseases in the capital city, Yerevan. Method: A chart review study was conducted in 2014. Data were abstracted from medical charts of adults (>= 18 years) with a fever (>= 38 degrees C), who were hospitalized (for >= 24 h) in 2010-2012. Results: Of the 600 patients whose charts were analyzed, 76 % were from Yerevan and 51 % were male; the mean age (+/- standard deviation) was 35.5 (+/- 16) years. Livestock exposure was recorded in 5 % of charts. Consumption of undercooked meat and unpasteurized dairy products were reported in 11 and 8 % of charts, respectively. Intestinal infections (51 %) were the most frequently reported final medical diagnoses, followed by diseases of the respiratory system (11 %), infectious mononucleosis (9.5 %), chickenpox (8.3 %), brucellosis (8.3 %), viral hepatitis (3.2 %), and erysipelas (1.5 %). Reviewed medical charts included two cases of fever of unknown origin (FUO), two cutaneous anthrax cases, two leptospirosis cases, three imported malaria cases, one case of rickettsiosis, and one case of rabies. Engagement in agricultural activities, exposure to animals, consumption of raw or unpasteurized milk, and male gender were significantly associated with brucellosis. Conclusion: Our analysis indicated that brucellosis was the most frequently reported zoonotic disease among hospitalized febrile patients. Overall, these study results suggest that zoonotic and arboviral infections were not common etiologies among febrile adult patients admitted to the Nork Infectious Diseases Clinical Hospital in Armenia. C1 [Paronyan, Lusine; Bakunts, Vahe; Palayan, Karo] Minist Hlth Armenia, Natl Ctr Dis Control & Prevent, Yerevan, Armenia. [Zardaryan, Eduard; Gevorgyan, Zaruhi; Asoyan, Vigen; Apresyan, Hripsime; Hovhannisyan, Alvard] Nork Infect Dis Clin Hosp, Minist Hlth Armenia, Yerevan, Armenia. [Bautista, Christian T.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Kuchuloria, Tinatin; Rivard, Robert G.] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. RP Paronyan, L (reprint author), Minist Hlth Armenia, Natl Ctr Dis Control & Prevent, Yerevan, Armenia. EM lusineparonyan@yahoo.com FU Defense Threat Reduction Agency, within U.S. Department of Defense [TAP-H1] FX This study was funded by the Defense Threat Reduction Agency, within the U.S. Department of Defense under project TAP-H1. The views expressed herein are those of the authors and do not necessarily reflect the official policy or position of the Department of the Army, Department of the Defense, the U.S. Government, or any organization listed. Some authors are employees of the U.S. Government. This work was prepared as part of their official duties and, as such, there is no copyright to be transferred. NR 29 TC 0 Z9 0 U1 5 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD AUG 24 PY 2016 VL 16 AR 445 DI 10.1186/s12879-016-1764-z PG 8 WC Infectious Diseases SC Infectious Diseases GA DT9KE UT WOS:000381817300002 PM 27553785 ER PT J AU Simone-Finstrom, M Li-Byarlay, H Huang, MH Strand, MK Rueppell, O Tarpy, DR AF Simone-Finstrom, Michael Li-Byarlay, Hongmei Huang, Ming H. Strand, Micheline K. Rueppell, Olav Tarpy, David R. TI Migratory management and environmental conditions affect lifespan and oxidative stress in honey bees SO SCIENTIFIC REPORTS LA English DT Article ID NATIONAL-SURVEY; COLONY LOSSES; USA; PEROXIDATION; AGGRESSION; DROSOPHILA; LONGEVITY; DISEASE; WORKERS; STATES AB Most pollination in large-scale agriculture is dependent on managed colonies of a single species, the honey bee Apis mellifera. More than 1 million hives are transported to California each year just to pollinate the almonds, and bees are trucked across the country for various cropping systems. Concerns have been raised about whether such "migratory management" causes bees undue stress; however to date there have been no longer-term studies rigorously addressing whether migratory management is detrimental to bee health. To address this issue, we conducted field experiments comparing bees from commercial and experimental migratory beekeeping operations to those from stationary colonies to quantify effects on lifespan, colony health and productivity, and levels of oxidative damage for individual bees. We detected a significant decrease in lifespan of migratory adult bees relative to stationary bees. We also found that migration affected oxidative stress levels in honey bees, but that food scarcity had an even larger impact; some detrimental effects of migration may be alleviated by a greater abundance of forage. In addition, rearing conditions affect levels of oxidative damage incurred as adults. This is the first comprehensive study on impacts of migratory management on the health and oxidative stress of honey bees. C1 [Simone-Finstrom, Michael; Li-Byarlay, Hongmei; Huang, Ming H.; Tarpy, David R.] North Carolina State Univ, Dept Entomol, Raleigh, NC 27695 USA. [Li-Byarlay, Hongmei; Tarpy, David R.] North Carolina State Univ, WM Keck Ctr Behav Biol, Raleigh, NC 27695 USA. [Li-Byarlay, Hongmei; Rueppell, Olav] Univ N Carolina, Dept Biol, Greensboro, NC 27412 USA. [Strand, Micheline K.] US Army, Res Off, Div Life Sci, Res Triangle Pk, NC 27709 USA. RP Simone-Finstrom, M (reprint author), North Carolina State Univ, Dept Entomol, Raleigh, NC 27695 USA. EM Michael.SimoneFinstrom@ars.usda.gov OI Rueppell, Olav/0000-0001-5370-4229 FU National Research Council; Army Research Laboratory; [W911NF-04-D-0003]; [W911NF-15-2-0045] FX We would like to thank Jennifer Keller for assistance in conducting the field experiments and sample collection, Jeff Lee for allowing us to use his colonies for this experiment, Ravi Dixit, Cheyenne Lashmit, and Jason Brannock for assistance with the oxidative stress assay data collection, and Kate Aronstein and Mike Goblirsch for helpful comments. This research was supported by grants W911NF-04-D-0003 and W911NF-15-2-0045 to DRT, OR and MKS from the Army Research Laboratory and by funding from the National Research Council to HL-B. NR 48 TC 1 Z9 1 U1 28 U2 32 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD AUG 24 PY 2016 VL 6 AR 32023 DI 10.1038/srep32023 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DT9WM UT WOS:000381853000001 PM 27554200 ER PT J AU Hota, SS Tandel, SK Chowdhury, P Ahmad, I Carpenter, MP Chiara, CJ Greene, JP Hoffman, CR Jackson, EG Janssens, RVF Kay, BP Khoo, TL Kondev, FG Lakshmi, S Lalkovski, S Lauritsen, T Lister, CJ McCutchan, EA Moran, K Peterson, D Shirwadkar, U Seweryniak, D Stefanescu, I Toh, Y Zhu, S AF Hota, S. S. Tandel, S. K. Chowdhury, P. Ahmad, I. Carpenter, M. P. Chiara, C. J. Greene, J. P. Hoffman, C. R. Jackson, E. G. Janssens, R. V. F. Kay, B. P. Khoo, T. L. Kondev, F. G. Lakshmi, S. Lalkovski, S. Lauritsen, T. Lister, C. J. McCutchan, E. A. Moran, K. Peterson, D. Shirwadkar, U. Seweryniak, D. Stefanescu, I. Toh, Y. Zhu, S. TI Population and decay of a K-pi=8(-) two-quasineutron isomer in Pu-244 SO PHYSICAL REVIEW C LA English DT Article ID SUPERHEAVY ELEMENTS; HEAVY-ELEMENTS; IN-BEAM; NUCLEI; SPECTROSCOPY; PU; STABILITY; STATES AB The decay of a K-pi = 8(-) isomer in Pu-244 and the collective band structures populating the isomer were studied using deep inelastic excitations with Ti-47 and Pb-208 beams, respectively. Precise measurements of M1/E2 branching ratios in the band confirm a 9/2(-)[734](nu)circle times 7/2(+)[624](nu) configuration assignment for the isomer, validating the systematics of K-pi = 8(-), two-quasineutron isomers observed in even-Z, N = 150 isotones. These isomers around the deformed shell gap at N = 152 provide critical benchmarks for theoretical predictions of single-particle energies in this gateway region to superheavy nuclei. C1 [Hota, S. S.; Tandel, S. K.; Chowdhury, P.; Jackson, E. G.; Lakshmi, S.; Lister, C. J.; Moran, K.; Shirwadkar, U.] Univ Massachusetts, Dept Phys, Lowell, MA 01854 USA. [Ahmad, I.; Carpenter, M. P.; Chiara, C. J.; Greene, J. P.; Hoffman, C. R.; Lauritsen, T.; Lister, C. J.; McCutchan, E. A.; Peterson, D.; Seweryniak, D.; Stefanescu, I.; Zhu, S.] Argonne Natl Lab, Div Phys, Argonne, IL 60439 USA. [Chiara, C. J.; Janssens, R. V. F.; Kay, B. P.; Khoo, T. L.; Kondev, F. G.] Argonne Natl Lab, Nucl Engn Div, 9700 S Cass Ave, Argonne, IL 60439 USA. [Chiara, C. J.; Seweryniak, D.; Stefanescu, I.] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA. [Lalkovski, S.] Univ Sofia, Sofia 1164, Bulgaria. [Toh, Y.] Japan Atom Energy Agcy, Naka, Ibaraki 3191195, Japan. [Hota, S. S.] Australian Natl Univ, Dept Nucl Phys, RSPE, Canberra, ACT 2601, Australia. [Tandel, S. K.] UM DAE Ctr Excellence Basic Sci, Bombay 400098, Maharashtra, India. [Chiara, C. J.] Army Res Lab, Adelphi, MD 20783 USA. [Lakshmi, S.; Shirwadkar, U.] Radiat Monitoring Devices Inc, Watertown, MA 02472 USA. [McCutchan, E. A.] Brookhaven Natl Lab, Natl Nucl Data Ctr, Upton, NY 11973 USA. RP Chowdhury, P (reprint author), Univ Massachusetts, Dept Phys, Lowell, MA 01854 USA. EM partha_chowdhury@uml.edu RI Kay, Benjamin/F-3291-2011 OI Kay, Benjamin/0000-0002-7438-0208 FU Office of Basic Energy Science, U.S. Department of Energy; U.S. Department of Energy, Office of Science, Office of Nuclear Physics [DE-FG02-94ER40848, DE-FG02-94ER40834, DE-AC02-06CH11357]; National Science Foundation [PHY-1203100] FX The trans-plutonium element production facilities at Oak Ridge National Laboratory, supported by the Office of Basic Energy Science, U.S. Department of Energy, is acknowledged for providing enriched isotopic material for the targets. This work is supported by the U.S. Department of Energy, Office of Science, Office of Nuclear Physics, under Grants No. DE-FG02-94ER40848 and No. DE-FG02-94ER40834, and Contract No. DE-AC02-06CH11357, and the National Science Foundation under Grant No. PHY-1203100. This research used resources of the ATLAS facility at ANL, which is a DOE Office of Science user facility. NR 36 TC 0 Z9 0 U1 3 U2 3 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9985 EI 2469-9993 J9 PHYS REV C JI Phys. Rev. C PD AUG 22 PY 2016 VL 94 IS 2 AR 021303 DI 10.1103/PhysRevC.94.021303 PG 5 WC Physics, Nuclear SC Physics GA DU0KL UT WOS:000381892200001 ER PT J AU Weingarten, NS Rice, BM AF Weingarten, N. Scott Rice, Betsy M. TI Evaluation of ReaxFF-lg force fields for use in molecular dynamics simulations of sucrose SO THEORETICAL CHEMISTRY ACCOUNTS LA English DT Article DE Sucrose; Molecular dynamics; Reactive potential; Polymorphism ID ENERGETIC MATERIALS; SUGAR; MECHANOCHEMISTRY; MODELS; WATER AB We have performed equilibrium molecular dynamics (MD) simulations using four different ReaxFF-lg parameterizations to determine the best set for use in modeling crystalline sucrose (C12H22O11). The first set of parameters (referred to as Goddard) is from the original ReaxFF-lg paper (Liu et al. in J Phys Chem A 115:11016-11022, 2011). The other three (Models A, B, and C) were developed at ARL using the multiple objective evolutionary strategies (MOES) software (Larentzos et al. in J Chem Theory Comput 11:381-391, 2015). Numerous structural parameters are obtained from the simulations and compared to experimental values, including density, lattice constants and angles, atomic positions, and molecular center of mass positions. The two potentials that best predict sucrose at the ambient state are also used in simulations of sucrose in the phase II polymorphic state, a high-pressure phase which recent experiments have uncovered. We have found that the Goddard model is the best overall potential for MD simulations of sucrose over a wide pressure range. C1 [Weingarten, N. Scott; Rice, Betsy M.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Weingarten, NS (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM neil.s.weingarten.civ@mail.mil NR 31 TC 0 Z9 0 U1 11 U2 13 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1432-881X EI 1432-2234 J9 THEOR CHEM ACC JI Theor. Chem. Acc. PD AUG 20 PY 2016 VL 135 IS 9 AR 227 DI 10.1007/s00214-016-1973-y PG 9 WC Chemistry, Physical SC Chemistry GA DU3SI UT WOS:000382132100001 ER PT J AU Williams, KS Rodriguez-Santiago, V Andzelm, JW AF Williams, Kristen S. Rodriguez-Santiago, Victor Andzelm, Jan W. TI Modeling reaction pathways for hydrogen evolution and water dissociation on magnesium SO ELECTROCHIMICA ACTA LA English DT Article DE Magnesium; Hydrogen Evolution Reaction; Kinetics; Thermodynamics; Modeling ID DOPED MG(0001) SURFACE; DENSITY-FUNCTIONAL THEORY; ELECTRONIC-STRUCTURE; AB-INITIO; MECHANISM; CORROSION; MG; DIFFUSION; DISSOLUTION; MOLECULES AB There are several chemical and electrochemical reactions that occur on a solvated magnesium surface, many of which contribute to the localized corrosion of magnesium and its alloys. The hydrogen evolution reaction (HER) is of particular interest because corrosion rates for different Mg alloys can be estimated by in situ monitoring of HER from a corroding sample surface. Therefore, a detailed mechanism for the HER on magnesium is proposed that connects the initial water dissociation reaction with the Tafel reaction through a self-consistent pathway involving adsorbed species. First principles modeling using Density Functional Theory (DFT) is used to map this reaction pathway on Mg(0001) and to determine the thermodynamic variables and kinetic barriers for each reaction in the scheme. An alternative mechanism for HER is also modeled that involves subsurface hydrogen, but this mechanism is found to have a negligible Gibbs free energy. It is also found that water dissociation occurs over the Mg Mg bridging site and has a large thermodynamic driving force. Reactions involving multiple water molecules and adsorbed species are modeled, as well, and it is found that the presence of Hads and OHads provides a thermodynamic driving force for water dissociation while also increasing the activation barrier for the Tafel reaction. Hence, DFT calculations show that the presence of adsorbed species can have a large impact on the kinetics of chemical and electrochemical reactions that occur on the Mg surface. (C) 2016 Published by Elsevier Ltd. C1 [Williams, Kristen S.; Rodriguez-Santiago, Victor; Andzelm, Jan W.] US Army, Res Lab, Mat & Mfg Sci Div, Aberdeen Proving Ground, MD 21005 USA. [Rodriguez-Santiago, Victor] Naval Air Syst Command NAVAIR, Corros & Wear Branch, Patuxent River, MD 20670 USA. [Williams, Kristen S.] Boeing Res & Technol, 499 Boeing Blvd SW,M-C JN-08, Huntsville, AL 35824 USA. RP Williams, KS; Andzelm, JW (reprint author), US Army, Res Lab, RDRL WMM G, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA.; Williams, KS; Andzelm, JW (reprint author), Boeing Res & Technol, 499 Boeing Blvd SW,M-C JN-08, Huntsville, AL 35824 USA. EM kristen.s.williams@boeing.com; victor.rodriguezsant@navy.mil; jan.w.andzelm.civ@mail.mil FU DoD High Performance Computing Modernization Program at the U.S. Air Force Research Laboratory DoD Supercomputing Resource Center FX K.W. and V.R.S. were supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARL. This work was also supported in part by a grant of computer time from the DoD High Performance Computing Modernization Program at the U.S. Air Force Research Laboratory DoD Supercomputing Resource Center. K. W. would like to acknowledge Dr. John R. Scully (University of Virginia) for helpful discussions about the hydrogen evolution reaction. Drs. Santanu Chaudhuri and Aslihan Sumer (Illinois Applied Research Institute) are also thanked for suggesting improvements to the proposed models. NR 57 TC 3 Z9 3 U1 50 U2 50 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0013-4686 EI 1873-3859 J9 ELECTROCHIM ACTA JI Electrochim. Acta PD AUG 20 PY 2016 VL 210 BP 261 EP 270 DI 10.1016/j.electacta.2016.04.128 PG 10 WC Electrochemistry SC Electrochemistry GA DS4IZ UT WOS:000380746100033 ER PT J AU Sun, CF Glaz, BJ Okada, M Baker, E Cheng, XY Karna, SP Wang, YH AF Sun, Chuan-Fu Glaz, Bryan J. Okada, Morihiro Baker, Edward, III Cheng, Xi-Yuan Karna, Shashi P. Wang, YuHuang TI Blocking Oxidation Failures of Carbon Nanotubes through Selective Protection of Defects SO ADVANCED MATERIALS LA English DT Article ID ATOMIC LAYER DEPOSITION; GRAPHENE; TRANSPARENT; SILICON AB The selective growth of Al2O3 islands over defect sites on the surface of carbon nanotubes significantly increases the oxidation breakdown threshold to 6.8 W cm(-2), more than double than that of unprotected films. The elevated input power enables thermoacoustic emissions at loud audible sound pressure levels of 90.1 dB, which are inaccessible with the unprotected films. C1 [Sun, Chuan-Fu; Okada, Morihiro; Baker, Edward, III; Cheng, Xi-Yuan; Wang, YuHuang] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA. [Glaz, Bryan J.; Karna, Shashi P.] US Army Res Lab, Aberdeen, MD 21005 USA. RP Glaz, BJ (reprint author), US Army Res Lab, Aberdeen, MD 21005 USA. EM bryan.j.glaz.civ@mail.mil; yhw@umd.edu RI Wang, YuHuang/B-4738-2009; SUN, CHUAN-FU/E-8083-2010 OI Wang, YuHuang/0000-0002-5664-1849; SUN, CHUAN-FU/0000-0003-3311-5982 FU Army Research Office [W911NF1420024]; Nanostructures for Electrical Energy Storage (NEES), an Energy Frontier Research Center - U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DESC0001160]; DOE Advanced Research Projects Agency - Energy [DEAR0000550] FX The authors are grateful to T. Kreutzfeldt, J. Hryunuk, and C. Kroninger from the U.S. Army Research Laboratory for assistance with the acoustic measurements, K. Gaskell of the Surface Analysis Center for assistance with XPS, S. C. Liou from Maryland NanoCenter for assistance with TEM, J. Ramsey of FLIR Systems, Inc. for assistance with infrared imaging, and P. Wang for assistance with schematic figures. This work was supported in part by the Army Research Office under Cooperative Agreement No. W911NF1420024. C.-F.S. was partially supported by the Nanostructures for Electrical Energy Storage (NEES), an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences under Award No. DESC0001160. TGA characterization is facilitated by using an instrument supported by the DOE Advanced Research Projects Agency - Energy under Grant No. DEAR0000550. NR 32 TC 1 Z9 1 U1 16 U2 16 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 0935-9648 EI 1521-4095 J9 ADV MATER JI Adv. Mater. PD AUG 17 PY 2016 VL 28 IS 31 BP 6672 EP + DI 10.1002/adma.201601027 PG 9 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA DU8RJ UT WOS:000382481200019 PM 27214267 ER PT J AU Pathak, A Chauhan, A Blom, J Indest, KJ Jung, CM Stothard, P Bera, G Green, SJ Ogram, A AF Pathak, Ashish Chauhan, Ashvini Blom, Jochen Indest, Karl J. Jung, Carina M. Stothard, Paul Bera, Gopal Green, Stefan J. Ogram, Andrew TI Comparative Genomics and Metabolic Analysis Reveals Peculiar Characteristics of Rhodococcus opacus Strain M213 Particularly for Naphthalene Degradation SO PLOS ONE LA English DT Article ID POLYCYCLIC AROMATIC-HYDROCARBONS; HORIZONTAL GENE-TRANSFER; DEGRADING BACTERIUM; PSEUDOMONAS; SEQUENCE; ISLAND; SOIL; EVOLUTION; BIODEGRADATION; CATABOLISM AB The genome of Rhodococcus opacus strain M213, isolated from a fuel-oil contaminated soil, was sequenced and annotated which revealed a genome size of 9,194,165 bp encoding 8680 putative genes and a G+ C content of 66.72%. Among the protein coding genes, 71.77% were annotated as clusters of orthologous groups of proteins (COGs); 55% of the COGs were present as paralog clusters. Pulsed field gel electrophoresis (PFGE) analysis of M213 revealed the presence of three different sized replicons-a circular chromosome and two megaplasmids (pNUO1 and pNUO2) estimated to be of 750Kb 350Kb in size, respectively. Conversely, using an alternative approach of optical mapping, the plasmid replicons appeared as a circular similar to 1.2 Mb megaplasmid and a linear, similar to 0.7 Mb megaplasmid. Genome-wide comparative analysis of M213 with a cohort of sequenced Rhodococcus species revealed low syntenic affiliation with other R. opacus species including strains B4 and PD630. Conversely, a closer affiliation of M213, at the functional (COG) level, was observed with the catabolically versatile R. jostii strain RHA1 and other Rhodococcii such as R. wratislaviensis strain IFP 2016, R. imtechensis strain RKJ300, Rhodococcus sp. strain JVH1, and Rhodococcus sp. strain DK17, respectively. An in-depth, genome-wide comparison between these functional relatives revealed 971 unique genes in M213 representing 11% of its total genome; many associating with catabolic functions. Of major interest was the identification of as many as 154 genomic islands (GEIs), many with duplicated catabolic genes, in particular for PAHs; a trait that was confirmed by PCR-based identification of naphthalene dioxygenase (NDO) as a representative gene, across PFGE-resolved replicons of strain M213. Interestingly, several plasmid/ GEI-encoded genes, that likely participate in degrading naphthalene (NAP) via a peculiar pathway, were also identified in strain M213 using a combination of bioinformatics, metabolic analysis and gene expression measurements of selected catabolic genes by RT-PCR. Taken together, this study provides a comprehensive understanding of the genome plasticity and ecological competitiveness of strain M213 likely facilitated by horizontal gene transfer (HGT), bacteriophage attacks and genomic reshuffling-aspects that continue to be understudied and thus poorly understood, in particular for the soil-borne Rhodococcii. C1 [Pathak, Ashish; Chauhan, Ashvini] Florida A&M Univ, Sch Environm, Tallahassee, FL 32307 USA. [Blom, Jochen] Univ Giessen, Bioinformat & Syst Biol, Giessen, Germany. [Indest, Karl J.; Jung, Carina M.] US Army Engn Res & Dev Ctr, Environm Proc Branch, Vicksburg, MS USA. [Stothard, Paul] Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB, Canada. [Bera, Gopal] Texas A&M Univ, Geochem & Environm Res Grp, College Stn, TX USA. [Green, Stefan J.] Univ Illinois, DNA Serv Facil, Chicago, IL USA. [Ogram, Andrew] Univ Florida, Soil & Water Sci Dept, Gainesville, FL USA. RP Chauhan, A (reprint author), Florida A&M Univ, Sch Environm, Tallahassee, FL 32307 USA. EM ashvini.chauhan@famu.edu FU School of Graduate Studies, Florida AM University; Department of Defense (DoD) [W911NF-10-1-0146, W911NF-10-R-0006]; Savannah River Nuclear Solutions [0000217620] FX The authors acknowledge the support provide by the School of Graduate Studies, Florida A&M University and funding obtained from two grants funded by the Department of Defense (DoD)-W911NF-10-1-0146 and W911NF-10-R-0006. This study was also funded partly by the Savannah River Nuclear Solutions under subcontract #0000217620. NR 76 TC 0 Z9 0 U1 23 U2 23 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD AUG 17 PY 2016 VL 11 IS 8 AR e0161032 DI 10.1371/journal.pone.0161032 PG 32 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DT4YN UT WOS:000381487600056 ER PT J AU Gilchuk, P Hill, TM Guy, C McMaster, SR Boyd, KL Rabacal, WA Lu, PC Shyr, Y Kohlmeier, JE Sebzda, E Green, DR Joyce, S AF Gilchuk, Pavlo Hill, Timothy M. Guy, Clifford McMaster, Sean R. Boyd, Kelli L. Rabacal, Whitney A. Lu, Pengcheng Shyr, Yu Kohlmeier, Jacob E. Sebzda, Eric Green, Douglas R. Joyce, Sebastian TI A Distinct Lung-Interstitium-Resident Memory CD8(+) T Cell Subset Confers Enhanced Protection to Lower Respiratory Tract Infection SO CELL REPORTS LA English DT Article ID INFLUENZA-VIRUS INFECTION; IN-VIVO; IMMUNITY; ANTIGEN; RESPONSES; SKIN; IMMUNIZATION; MICE AB The nature and anatomic location of the protective memory CD8(+) T cell subset induced by intranasal vaccination remain poorly understood. We developed a vaccination model to assess the anatomic location of protective memory CD8(+) T cells and their role in lower airway infections. Memory CD8(+) T cells elicited by local intranasal, but not systemic, vaccination with an engineered non-replicative CD8(+) T cell-targeted antigen confer enhanced protection to a lethal respiratory viral challenge. This protection depends on a distinct CXCR3 LO resident memory CD8(+) T (TRM) cell population that preferentially localizes to the pulmonary interstitium. Because they are positioned close to the mucosa, where infection occurs, interstitial TRM cells act before inflammation can recruit circulating memory CD8(+) T cells into the lung tissue. This results in a local protective immune response as early as 1 day post-infection. Hence, vaccine strategies that induce lung interstitial TRM cells may confer better protection against respiratory pathogens. C1 [Gilchuk, Pavlo; Joyce, Sebastian] Tennessee Valley Healthcare Syst, Dept Vet Affairs, Nashville, TN 37232 USA. [Gilchuk, Pavlo; Hill, Timothy M.; Boyd, Kelli L.; Rabacal, Whitney A.; Sebzda, Eric; Joyce, Sebastian] Vanderbilt Univ, Sch Med, Dept Pathol Microbiol & Immunol, Nashville, TN 37232 USA. [Lu, Pengcheng; Shyr, Yu] Vanderbilt Univ, Sch Med, Vanderbilt Technol Adv Genom Anal & Res Design, Nashville, TN 37232 USA. [Lu, Pengcheng] Vanderbilt Univ, Sch Med, Dept Biostat, Nashville, TN 37232 USA. [Guy, Clifford; Green, Douglas R.] St Jude Childrens Res Hosp, Dept Immunol, 332 N Lauderdale St, Memphis, TN 38105 USA. [McMaster, Sean R.; Kohlmeier, Jacob E.] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA. [Hill, Timothy M.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. RP Joyce, S (reprint author), Tennessee Valley Healthcare Syst, Dept Vet Affairs, Nashville, TN 37232 USA.; Joyce, S (reprint author), Vanderbilt Univ, Sch Med, Dept Pathol Microbiol & Immunol, Nashville, TN 37232 USA. EM sebastian.joyce@vanderbilt.edu FU VA Merit Award [BX001444]; NIH [AI040079, HL054977, AI042284, HL121139, AI085062, GM007347, CA068485, DK058404, CA68485]; Vanderbilt Immunology Center; St. Jude Children's Research Hospital; [P30 CA021765] FX We thank L. Van Kaer for critical evaluation of the data and review of the manuscript. This work was supported by a VA Merit Award (BX001444) to S.J., NIH contracts (AI040079), research (HL054977, AI042284, HL121139, and AI085062), training (GM007347), core (CA068485 and DK058404), and center (CA68485) grants, and a Mini-Sabbatical Award to P.G. from the Vanderbilt Immunology Center. SPIM microscopy images were acquired at the Cell & Tissue Imaging Center, which is supported by St. Jude Children's Research Hospital and P30 CA021765. NR 37 TC 1 Z9 1 U1 2 U2 2 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 2211-1247 J9 CELL REP JI Cell Reports PD AUG 16 PY 2016 VL 16 IS 7 BP 1800 EP 1809 DI 10.1016/j.celrep.2016.07.037 PG 10 WC Cell Biology SC Cell Biology GA DT3JH UT WOS:000381376500003 PM 27498869 ER PT J AU Smith, DD Luckay, HA Chang, H Myneni, K AF Smith, David D. Luckay, H. A. Chang, Hongrok Myneni, Krishna TI Quantum-noise-limited sensitivity enhancement of a passive optical cavity by a fast-light medium SO PHYSICAL REVIEW A LA English DT Article ID GRAVITATIONAL-WAVE DETECTORS; RING-RESONATOR; INTERFEROMETERS AB We demonstrate that for a passive optical cavity containing a dispersive atomic medium, the increase in scale factor near the critical anomalous dispersion is not canceled by mode broadening or attenuation, resulting in an overall increase in the predicted quantum-noise-limited sensitivity. Enhancements of over two orders of magnitude are measured in the scale factor, which translates to greater than an order-of-magnitude enhancement in the predicted quantum-noise-limited measurement precision, by temperature-tuning a low-pressure vapor of noninteracting atoms in a low-finesse cavity close to the critical anomalous dispersion condition. The predicted enhancement in sensitivity is confirmed through Monte Carlo numerical simulations. C1 [Smith, David D.] NASA, Marshall Space Flight Ctr, Space Syst Dept, ES34, Huntsville, AL 35812 USA. [Luckay, H. A.] Torch Technol, 4035 Chris Dr,Suite C, Huntsville, AL 35802 USA. [Chang, Hongrok] Gen Atom Electromagnet Syst, 678 Discovery Dr, Huntsville, AL 35806 USA. [Myneni, Krishna] US Army, Aviat & Missile Res Dev & Engn Ctr, RDMR WDS MRI, Redstone Arsenal, AL 35898 USA. RP Smith, DD (reprint author), NASA, Marshall Space Flight Ctr, Space Syst Dept, ES34, Huntsville, AL 35812 USA. EM david.d.smith@nasa.gov FU NASA Space Technology Mission Directorate Game Changing Development Office; U.S. Army Aviation and Missile Research Development and Engineering Center (AMRDEC) Missile ST Program FX This work was sponsored by the NASA Space Technology Mission Directorate Game Changing Development Office as well as the U.S. Army Aviation and Missile Research Development and Engineering Center (AMRDEC) Missile S&T Program. H. A. Luckay was affiliated with Jacobs ESSSA Group, Jacobs Technology Inc., while performing the majority of this work. NR 25 TC 0 Z9 0 U1 4 U2 4 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9926 EI 2469-9934 J9 PHYS REV A JI Phys. Rev. A PD AUG 16 PY 2016 VL 94 IS 2 AR 023828 DI 10.1103/PhysRevA.94.023828 PG 13 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA DT4TE UT WOS:000381473100002 ER PT J AU de Souza, MS Pinyakorn, S Akapirat, S Pattanachaiwit, S Fletcher, JLK Chomchey, N Kroon, ED Ubolyam, S Michael, NL Robb, ML Phanuphak, P Kim, JH Phanuphak, N Ananworanich, J AF de Souza, Mark S. Pinyakorn, Suteeraporn Akapirat, Siriwat Pattanachaiwit, Supanit Fletcher, James L. K. Chomchey, Nitiya Kroon, Eugene D. Ubolyam, Sasiwimol Michael, Nelson L. Robb, Merlin L. Phanuphak, Praphan Kim, Jerome H. Phanuphak, Nittaya Ananworanich, Jintanat CA RV254 SEARCH010 Study Grp TI Initiation of Antiretroviral Therapy During Acute HIV-1 Infection Leads to a High Rate of Nonreactive HIV Serology SO CLINICAL INFECTIOUS DISEASES LA English DT Article DE HIV-1; acute HIV infection; Bangkok; immunoassay; seroreversion ID IMMUNODEFICIENCY-VIRUS TYPE-1; COMBINED P24 ANTIGEN; HIV-1-INFECTED CHILDREN; IMMUNE-RESPONSES; ANTIBODY-ASSAYS; SEROREVERSION; DIAGNOSIS; SPECIMENS; VIREMIA; SEROCONVERSION AB Background. Third-and fourth-generation immunoassays (IAs) are widely used in the diagnosis of human immunodeficiency virus (HIV) infection. Antiretroviral therapy (ART) during acute HIV infection (AHI) may impact HIV-specific antibodies, with failure to develop antibody or seroreversion. We report on the ability of diagnostic tests to detect HIV-specific antibodies in Thai participants initiating ART during AHI. Methods. Participants with detectable plasma HIV RNA but nonreactive HIV-specific immunoglobulin G, enrolled in an AHI study, were offered immediate initiation of ART. Participants were tested at initiation and at 12 and 24 weeks following treatment using standard second-, third-, and fourth-generation IAs and Western blot (WB). Results. Participants (N = 234) initiating ART at a median of 19 days (range, 1-62 days) from HIV exposure demonstrated different frequencies of reactivity prior to and following 24 weeks of ART depending on the IA. Third-generation IA nonreactivity prior to ART was 48%, which decreased to 4% following ART (P < .001). Fourth-generation IA nonreactivity was 18% prior to ART and 17% following ART (P = .720). Negative WB results were observed in 89% and 12% of participants prior to and following 24 weeks of ART, respectively (P < .001). Seroreversion to nonreactivity during ART was observed to at least one of the tests in 20% of participants, with fourth-generation IA demonstrating the highest frequency (11%) of seroreversion. Conclusions. HIV-specific antibodies may fail to develop and, when detected, may decline when ART is initiated during AHI. Although fourth-generation IA was the most sensitive at detecting AHI prior to ART, third-generation IA was the most sensitive during treatment. C1 [de Souza, Mark S.; Fletcher, James L. K.; Chomchey, Nitiya; Kroon, Eugene D.; Phanuphak, Praphan; Phanuphak, Nittaya; Ananworanich, Jintanat] SEARCH, Bangkok, Thailand. [de Souza, Mark S.; Pattanachaiwit, Supanit; Kroon, Eugene D.; Phanuphak, Praphan; Phanuphak, Nittaya] Thai Red Cross AIDS Res Ctr, Bangkok, Thailand. [de Souza, Mark S.] Cooper Human Syst, Cambridge, MA USA. [Pinyakorn, Suteeraporn; Robb, Merlin L.; Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Pinyakorn, Suteeraporn; Michael, Nelson L.; Robb, Merlin L.; Ananworanich, Jintanat] US Mil HIV Res Program, Bethesda, MD USA. [Akapirat, Siriwat] US Component, Armed Forces Res Inst Med Sci, Dept Retrovirol, Bangkok, Thailand. [Ubolyam, Sasiwimol] HIV Netherlands Australia Thailand Res Collaborat, Bangkok, Thailand. [Michael, Nelson L.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Kim, Jerome H.] Int Vaccine Inst, Seoul, South Korea. RP de Souza, MS (reprint author), Thai Red Cross AIDS Res Ctr, SEARCH, Tower 2,2nd Floor,104 Rajdumri Rd, Bangkok 10330, Thailand. EM markdes@searchthailand.org FU US Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, Maryland [W81XWH-07-2-0067] FX This work was supported by the US Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, Maryland, under a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the US Department of Defense. NR 40 TC 4 Z9 4 U1 5 U2 5 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD AUG 15 PY 2016 VL 63 IS 4 BP 555 EP 561 DI 10.1093/cid/ciw365 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA DV8QU UT WOS:000383202400019 PM 27317797 ER PT J AU Lesho, EP Clifford, RJ AF Lesho, Emil P. Clifford, Robert J. TI For Rapid Molecular Detection, Why Not a Whole Genome Approach? SO CLINICAL INFECTIOUS DISEASES LA English DT Letter ID ESCHERICHIA-COLI; DIAGNOSTICS C1 [Lesho, Emil P.; Clifford, Robert J.] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD USA. RP Lesho, EP (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM carolinelesho@yahoo.com NR 7 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD AUG 15 PY 2016 VL 63 IS 4 BP 570 EP + DI 10.1093/cid/ciw332 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA DV8QU UT WOS:000383202400023 PM 27225237 ER PT J AU Bland, CM Quidley, AM Love, BL Yeager, C McMichael, B Bookstaver, PB AF Bland, Christopher M. Quidley, April Miller Love, Bryan L. Yeager, Catherine McMichael, Bliss Bookstaver, P. Brandon TI Long-term pharmacotherapy considerations in the bariatric surgery patient SO AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY LA English DT Review ID GASTRIC BYPASS-SURGERY; INTENSIVE MEDICAL THERAPY; SLEEVE GASTRECTOMY; ALCOHOL-USE; PSYCHIATRIC MEDICATIONS; AMERICAN SOCIETY; OBESE-PATIENTS; WEIGHT-LOSS; FOLLOW-UP; MANAGEMENT AB Purpose. Pharmacists' role in optimizing long-term pharmacotherapy for bariatric surgery patients is detailed. Summary. Bariatric surgery patients provide a difficult challenge in terms of many pharmacotherapy issues, especially in the chronic care setting, where data on long-term effects of bariatric surgery are limited. The most common procedures are Roux-en-Y gastric bypass (RYGB), adjustable gastric banding, and sleeve gastrectomy. Sleeve gastrectomy has become the most common procedure in the United States, primarily because it has less overall chronic malabsorption effects than RYGB. Pharmacotherapy management is complicated by rapid weight loss combined with a number of pharmacokinetic changes, such as decreased absorption of some medications due to altered gastrointestinal tract anatomy and potentially increased concentrations of some medications due to a decreased volume of distribution resulting from weight loss. Nutritional and metabolic supplementation are of the utmost importance in order to limit deficiencies that can lead to a number of conditions. Many chronic diseases, including hypertension, diabetes, gastroesophageal reflux disease, and urinary incontinence, are improved by bariatric surgery but require close monitoring to ensure the effectiveness of maintenance pharmacotherapy and avoidance of adverse effects. Psychotropic medication management is also an important pharmacotherapy concern, as evidenced by antidepressants being the most commonly used medication class among preoperative bariatric surgery patients. Conclusion. Pharmacists have an increasing role in the chronic management of the bariatric surgery patient due to their knowledge of medication dosage forms and expertise in disease states affected by bariatric surgery. C1 [Bland, Christopher M.] Univ Georgia, Coll Pharm, Dept Clin & Adm Pharm, Southeastern Campus, Savannah, GA 31404 USA. [Quidley, April Miller] Vidant Med Ctr, Greenville, NC USA. [Love, Bryan L.; Bookstaver, P. Brandon] Univ South Carolina, South Carolina Coll Pharm, Dept Clin Pharm & Outcomes Sci, Columbia, SC 29208 USA. [Yeager, Catherine] Eisenhower Army Med Ctr, Family Med & Outpatient Behav Hlth Serv, Ft Gordon, GA USA. [McMichael, Bliss] Univ Georgia, Coll Pharm, Athens, GA 30602 USA. RP Bland, CM (reprint author), Univ Georgia, Coll Pharm, Dept Clin & Adm Pharm, Southeastern Campus, Savannah, GA 31404 USA. EM cmbland@uga.edu RI Love, Bryan/F-3158-2010 OI Love, Bryan/0000-0002-9221-9143 NR 81 TC 1 Z9 1 U1 5 U2 5 PU AMER SOC HEALTH-SYSTEM PHARMACISTS PI BETHESDA PA 7272 WISCONSIN AVE, BETHESDA, MD 20814 USA SN 1079-2082 EI 1535-2900 J9 AM J HEALTH-SYST PH JI Am. J. Health-Syst. Pharm. PD AUG 15 PY 2016 VL 73 IS 16 BP 1230 EP 1242 DI 10.2146/ajhp151062 PG 13 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA DT6IL UT WOS:000381587800011 PM 27354038 ER PT J AU Landolt, NK Bunupuradah, T Kosalaraksa, P Ubolyam, S Thammajaruk, N Cremers, S Zott, R Kerr, S Ananworanich, J AF Landolt, Nadia Kancheva Bunupuradah, Torsak Kosalaraksa, Pope Ubolyam, Sasiwimol Thammajaruk, Narukjaporn Cremers, Serge Zott, Roseann Kerr, Stephen Ananworanich, Jintanat CA HIV-NAT 176 Study TI High Variability of Hormonal Levels and No Clinically Relevant Interaction Between Ethinyl Estradiol, Desogestrel and Lopinavir/Ritonavir in a Small Sample of HIV-positive Adolescents SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE pharmacokinetic interactions; desogestrel; ethinyl estradiol; lopinavir; ritonavir; HIV-positive adolescents ID COMBINED ORAL-CONTRACEPTIVES; UDP-GLUCURONOSYLTRANSFERASE; SERUM PROGESTERONE; PHARMACOKINETICS; ETHINYLESTRADIOL; WOMEN; ETONOGESTREL; NEVIRAPINE; EFAVIRENZ; PLASMA AB Background:We report the pharmacokinetic interactions of combined oral contraceptive (COC) containing ethinyl estradiol (EE2)/desogestrel (DSG) with lopinavir/ritonavir (LPV/r) in 16 HIV-positive adolescents.Methods:We measured C-trough of EE2 and etonogestrel (ENG), the active metabolite of DSG, in HIV-positives on LPV/r-based ART; C-trough of LPV/r with and without COC; endogenous progesterone. EE2/ENG levels were compared with our own historical data of HIV-negative controls.Results:C-trough of EE2 and ENG varied from 3 to 57 pg/mL and from 1051 to 5000 pg/mL, respectively. The geometric mean ratios (GMR) of C-trough in HIV-positives on LPV/r with COC versus HIV-negative controls with COC only were 0.68 (95% CI: 0.42 to 1.08) or 32% decreased (P = 0.10) for EE2; and 1.08 (95% CI: 0.73 to 1.60) or 8% increased (P = 0.68) for ENG. Endogenous progesterone was <1.0 ng/mL in all participants, consistent with anovulation. C-trough of LPV decreased statistically insignificantly with COC and remained above the desired therapeutic minimum of 1.0 mg/L in all.Conclusions:The study found no clinically relevant interaction between EE2/DSG and LPV/r. This was supported by suppressed ovulation, assessed by low endogenous progesterone levels in all participants; and preserved antiretroviral activity, assessed by LPV/r levels above the desired therapeutic minimum in all participants. However, the high variability of hormonal levels warrants individual monitoring and further investigation. Condom use should always be encouraged for infection prevention. C1 [Landolt, Nadia Kancheva; Bunupuradah, Torsak; Ubolyam, Sasiwimol; Thammajaruk, Narukjaporn; Kerr, Stephen; Ananworanich, Jintanat] HIV Netherlands Australia Thailand Res Collaborat, Dept Med, Bangkok, Thailand. [Kosalaraksa, Pope] Khon Kaen Univ, Med Pediat Dept, Fac Med, Khon Kaen, Thailand. [Cremers, Serge; Zott, Roseann] Columbia Univ, Irving Inst Clin & Translat, Res Biomarkers Core Lab, Med Ctr, New York, NY USA. [Kerr, Stephen] Univ Amsterdam, Acad Med Ctr, Amsterdam Inst Global Hlth & Dev, Dept Global Hlth,Biostat, Amsterdam, Netherlands. [Ananworanich, Jintanat] Thai Red Cross AIDS Res Ctr, Bangkok, Thailand. [Ananworanich, Jintanat] SEARCH, Bangkok, Thailand. [Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. RP Landolt, NK (reprint author), HIV Netherlands Australia Thailand Res Collaborat, Bangkok, Thailand. EM nadia.kl@hivnat.org FU TREAT Asia/amfAR; Foundation for AIDS Research, through a ViiV Healthcare; AIDS LIFE Association FX This study was funded by TREAT Asia/amfAR, The Foundation for AIDS Research, through a grant from ViiV Healthcare, and additional support from the AIDS LIFE Association. The content of this publication is solely the responsibility of the authors and does not necessarily represent the official views of any of the institutions mentioned above. NR 36 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD AUG 15 PY 2016 VL 72 IS 5 BP 507 EP 512 DI 10.1097/QAI.0000000000000997 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA DT3KC UT WOS:000381378700007 ER PT J AU Mountney, A Boutte, AM Gilsdorf, J Lu, XC Tortella, FC Shear, DA AF Mountney, Andrea Boutte, Angela M. Gilsdorf, Janice Lu, Xi-Chun Tortella, Frank C. Shear, Deborah A. TI Intravenous Administration of Simvastatin Improves Cognitive Outcome following Severe Traumatic Brain Injury in Rats SO JOURNAL OF NEUROTRAUMA LA English DT Article DE antioxidants; behavioral assessments; biomarkers; penetrating ballistic-like brain injury; traumatic brain injury ID FIBRILLARY ACIDIC PROTEIN; COA REDUCTASE INHIBITORS; NITRIC-OXIDE SYNTHASE; COMBINATION THERAPY; UP-REGULATION; ATORVASTATIN; INCREASE; STATINS; MODEL; NEUROINFLAMMATION AB Simvastatin is a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor commonly used to reduce serum cholesterol. The beneficial effects of oral simvastatin have been reported in pre-clinical models of traumatic brain injury (TBI). The current study was designed to evaluate the potential beneficial effects of simvastatin in a model of severe penetrating TBI using an intravenous (IV) route of administration. Rats were subjected to unilateral frontal penetrating ballistic-like brain injury (PBBI), and simvastatin was delivered intravenously at 30 min and 6 h post-injury and continued once daily for either 4 or 10 days post-PBBI. Motor function was assessed on the rotarod and cognitive performance was evaluated using the Morris water maze (MWM) task. Serum levels of inflammatory cytokines and the astrocytic biomarker, glial fibrillary acidic protein (GFAP), were quantified at 1 h, 4 h, and 24 h post-injury. Histopathological damage was assessed at the terminal end-point. Rotarod testing revealed significant motor deficits in all injury groups but no significant simvastatin-induced therapeutic benefits. All PBBI-injured animals showed cognitive impairment on the MWM test; however, 10-day simvastatin treatment mitigated these effects. Animals showed significantly improved latency to platform and retention scores, whereas the 4-day treatment regimen failed to produce any significant improvements. Biomarker and cytokine analysis showed that IV simvastatin significantly reduced GFAP, interleukin (IL)-1 alpha, and IL-17 serum levels by 4.0-, 2.6-, and 7.0-fold, respectively, at 4 h post-injury. Collectively, our results demonstrate that IV simvastatin provides significant protection against injury-induced cognitive dysfunction and reduces TBI-specific biomarker levels. Further research is warranted to identify the optimal dose and therapeutic window for IV delivery of simvastatin in models of severe TBI. C1 [Mountney, Andrea; Boutte, Angela M.; Gilsdorf, Janice; Lu, Xi-Chun; Tortella, Frank C.; Shear, Deborah A.] Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Mountney, A (reprint author), Walter Reed Army Inst Res, Brain Trauma Neuroprotect Neurorestorat, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave,Room 2A40, Silver Spring, MD 20910 USA. EM andrea.mountney.mil@mail.mil NR 39 TC 0 Z9 0 U1 1 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD AUG 15 PY 2016 VL 33 IS 16 BP 1492 EP + DI 10.1089/neu.2015.4139 PG 10 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DU6ED UT WOS:000382305900003 PM 26542887 ER PT J AU Mancuso, JD Diffenderfer, JM Ghassemieh, BJ Horne, DJ Kao, TC AF Mancuso, James D. Diffenderfer, Jeffrey M. Ghassemieh, Bijan J. Horne, David J. Kao, Tzu-Cheg TI The Prevalence of Latent Tuberculosis Infection in the United States SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Article DE latent tuberculosis; tuberculosis epidemiology; nutrition survey; tuberculin test; IFN-gamma release tests ID GAMMA RELEASE ASSAYS; SKIN-TEST; HEALTH; TRENDS; RISK; GOLD; POPULATION; GUIDELINES; DIAGNOSIS; EXPOSURE AB Rationale: Individuals with latent tuberculosis infection (LTBI) represent a reservoir of infection, many of whom will progress to tuberculosis (TB) disease. A central pillar of TB control in the United States is reducing this reservoir through targeted testing and treatment. Objectives: To estimate the prevalence of LTBI in the United States using the tuberculin skin test (TST) and an IFN-y release assay. Methods: We used nationally representative data from the 2011-2012 National Health and Nutrition Examination Survey (n = 6,083 aged yr). LTBI was measured by both the TST and QuantiFERON-TB Gold In-Tube test (QFT-GIT). Weighted population, prevalence, and multiple'logistic regression were used. Measurements and Main Results: The estimated prevalence of LTBI in 2011-2012 was 4.4% as measured by the TST and 4.8% by QFT-GIT, corresponding to 12,398,000 and 13,628,000 individuals, respectively. Prevalence declined slightly since 2000 among the U.S. born but remained constant among the foreign born. Earlier birth cohorts consistently had higher prevalence than more recent ones. Higher risk groups included the foreign born, close contact with a case of TB disease, and certain racial/ethnic groups. Conclusions: After years of decline, the prevalence of LTBI remained relatively constant between 2000 and 2011. A large reservoir of 12.4 million still exists, with foreign-born persons representing an increasingly larger proportion of this reservoir (73%). Estimates and risk factors for LTBI were generally similar between the TST and QFT-GIT. The updated estimates of LTBI and associated risk groups can help improve targeted testing and treatment in the United States. C1 [Mancuso, James D.; Diffenderfer, Jeffrey M.; Kao, Tzu-Cheg] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biostat, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. [Diffenderfer, Jeffrey M.] Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD USA. [Ghassemieh, Bijan J.; Horne, David J.] Univ Washington, Dept Med, Div Pulm & Crit Care Med, Seattle, WA USA. [Horne, David J.] Univ Washington, Dept Global Hlth, Seattle, WA USA. [Horne, David J.] Univ Washington, Firland Northwest TB Ctr, Seattle, WA USA. RP Mancuso, JD (reprint author), Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biostat, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM james.mancuso@usuhs.edu FU Uniformed Services University of the Health Sciences [R087U7] FX Partially supported by the Uniformed Services University of the Health Sciences intramural grant R087U7. NR 40 TC 3 Z9 3 U1 3 U2 3 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PD AUG 15 PY 2016 VL 194 IS 4 BP 501 EP 509 DI 10.1164/rccm.201508-1683OC PG 9 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA DT4JQ UT WOS:000381446400015 PM 26866439 ER PT J AU Lotufo, GR Farrar, JD Biedenbach, JM Laird, JG Krasnec, MO Lay, C Morris, JM Gielazyn, ML AF Lotufo, Guilherme R. Farrar, J. Daniel Biedenbach, James M. Laird, Jennifer G. Krasnec, Michelle O. Lay, Claire Morris, Jeffrey M. Gielazyn, Michel L. TI Effects of sediment amended with Deepwater Horizon incident slick oil on the infaunal amphipod Leptocheirus plumulosus SO MARINE POLLUTION BULLETIN LA English DT Article DE Oil spill; Chronic toxicity; Sediment; Gulf of Mexico; Deepwater Horizon; Amphipod ID AROMATIC-HYDROCARBON MIXTURES; FIELD-COLLECTED SEDIMENTS; ESTUARINE AMPHIPOD; COASTAL WETLANDS; SPIKED SEDIMENT; ACUTE TOXICITY; SPILL; REPRODUCTION; SURVIVAL; BIOASSAY AB Crude oil released from the Deepwater Horizon disaster into the Gulf of Mexico posed potential impacts to infaunal invertebrates inhabiting near shore habitats. The effects of sediment-associated weathered slick oil on the amphipod Leptocheirus plumulosus was assessed using 28-d exposures to total PAH sediment concentrations ranging from 0.3 to 24 mg/kg (sum of 50 PAHs or tPAH50). Survival and growth rate were significantly decreased in the 2.6,11.4 and 24.2 mg/kg treatments, but only growth in 5.5 mg/kg. Offspring production was dramatically decreased but was variable and significantly different only for 24.2 mg/kg. The concentrations associated with 20% decreases relative to reference were 1.05 (95% CI = 0-2.89) mg/kg tPAH50 for growth rate and 0.632 (95% CI = 0.11-2.15) mg/kg tPAH50 for offspring production. The concentrations of PAHs affecting amphipods are within the range of concentrations measured in marsh areas reportedly impacted by DWH oil after its release. Published by Elsevier Ltd. C1 [Lotufo, Guilherme R.; Farrar, J. Daniel; Biedenbach, James M.; Laird, Jennifer G.] US Army Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. [Krasnec, Michelle O.; Lay, Claire; Morris, Jeffrey M.] Abt Associates Inc, Boulder, CO 80302 USA. [Gielazyn, Michel L.] NOAA, Assessment & Restorat Div, St Petersburg, FL 33701 USA. RP Lotufo, GR (reprint author), US Army Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM guilherme.lotufo@usace.army.mil FU Natural Resource Damage Assessment (NRDA) FX The authors thank Ron Hall, Ian Lipton, Andrew McFadden and Mary Huisenga for technical assistance with data collection and sampling during experimentation. National Oceanic and Atmospheric Administration National Ocean Service staff and contractors reviewed the experimental design and a draft of the manuscript. This work was supported by funds provided as part of the Natural Resource Damage Assessment (NRDA) for the DWH oil spill. Data presented here are a subset of a larger toxicological database that is being generated as part of the Deepwater Horizon Natural Resource Damage Assessment. Therefore, these data will be subject to additional analysis and interpretation which may include interpretation in the context of additional data not presented here. Funding played no role in the design or interpretation of these data. Permission was granted by the Chief of Engineers to publish this material. NR 54 TC 0 Z9 0 U1 7 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0025-326X EI 1879-3363 J9 MAR POLLUT BULL JI Mar. Pollut. Bull. PD AUG 15 PY 2016 VL 109 IS 1 BP 253 EP 258 DI 10.1016/j.marpolbul.2016.05.073 PG 6 WC Environmental Sciences; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA DT7EP UT WOS:000381650200040 PM 27267114 ER PT J AU Reese, TR Thiel, DJ Cocker, KE AF Reese, Tyler R. Thiel, Derrick J. Cocker, Katherine E. TI Behavioral Disorders in Dementia: Appropriate Nondrug Interventions and Antipsychotic Use SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID ALZHEIMERS-DISEASE; DRUG TREATMENT; UNITED-STATES; RISK; MEDICATIONS; METAANALYSIS; RISPERIDONE; EFFICACY; DEATH AB Behavioral and psychological symptoms of dementia pose management challenges for caregivers and clinicians. First line nonpharmacologic treatments include eliminating physical and emotional stressors, modifying the patient's environment, and establishing daily routines. Family members and caregivers benefit from education about dementia symptoms and reminders that the behaviors are normal and unintentional. Cognitive and emotion-oriented interventions, sensory stimulation interventions, behavior management techniques, and other psychosocial interventions are modestly effective. In refractory cases, physicians may choose to prescribe off-label antipsychotics. Aripiprazole has the most consistent evidence of symptom improvement; however, this improvement is small. Olanzapine, quetiapine, and risperidone have inconsistent evidence of benefit. Physicians should use the smallest effective dose for the shortest possible duration to minimize adverse effects, most notably an increased mortality risk. Other adverse effects include anticholinergic and antidopaminergic effects, extrapyramidal symptoms, neuroleptic malignant syndrome, postural hypotension, metabolic syndrome, cardiac arrhythmia, and sedation. Patients should be monitored for these effects while receiving treatment; however, laboratory monitoring may be limited to patients receiving long-term therapy. Copyright (C) 2016 American Academy of Family Physicians. C1 [Reese, Tyler R.; Thiel, Derrick J.; Cocker, Katherine E.] Tripler Army Med Ctr, Family Med Residency Program, Honolulu, HI 96859 USA. RP Reese, TR (reprint author), MCHK FM, Tripler Army Med Ctr, 1 Jarret White Rd, Honolulu, HI 96859 USA. EM tyler.r.reese83@gmail.com NR 31 TC 0 Z9 0 U1 9 U2 10 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X EI 1532-0650 J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD AUG 15 PY 2016 VL 94 IS 4 BP 276 EP 282 PG 7 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA DT8XZ UT WOS:000381780300002 PM 27548592 ER PT J AU Nezafati, M Giri, A Hofmeister, C Cho, K Schneider, MM Zhou, L Sohn, YH Kim, CS AF Nezafati, Marjan Giri, Anit Hofmeister, Clara Cho, Kyu Schneider, Matthew M. Zhou, Le Sohn, Yongho Kim, Chang-Soo TI Atomistic study on the interaction of nitrogen and Mg lattice and the nitride formation in nanocrystalline Mg alloys synthesized using cryomilling process SO ACTA MATERIALIA LA English DT Article DE Magnesium alloys; Nanocrystalline alloys; Powder processing; Density functional theory (DFT); Transmission electron microscopy (TEM); Electron energy-loss spectroscopy (EELS) ID METAL-MATRIX-COMPOSITES; SYNCHRONOUS-TRANSIT; MECHANICAL-BEHAVIOR; NANOCOMPOSITES; MAGNESIUM; ALUMINUM; STRENGTH; ENERGY; MICROSTRUCTURE; ABSORPTION AB Cryomilling is a broadly applied technique to synthesize nanostructured alloys and composites through powder metallurgy (PM) processing. Understanding the interactions between liquid nitrogen and the nanostructured metal powder is important as it can potentially impact the mechanical performance of these materials. In this study, we performed a series of ab initio density functional theory (DFT) computations to examine the interactions of liquid nitrogen and Mg-based matrices and the formation of Mg nitrides. The diffusion energy barriers of nitrogen in the Mg and/or Mg-Al alloys were systematically quantified by calculating the transition state (TS) for the displacement of nitrogen between two neighboring equivalent positions. The TS calculation results indicate that diffusion of N atoms is much easier than that of N-2 molecule in the Mg matrix. It is predicted that at least similar to 0.4 eV is required to overcome the diffusion energy barrier in the Mg matrix. We also quantified the formation energy of Mg nitride in the matrix. The presence of Mg nitride was demonstrated experimentally using transmission electron microscopy (TEM) and electron energy-loss spectroscopy (EELS). In conjunction with the DFT computations and TEM/EELS analysis, we performed analytical calculations for the strain energy introduced during cryomilling to examine the impacts of processing parameters. (C) 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Nezafati, Marjan; Kim, Chang-Soo] Univ Wisconsin, Mat Sci & Engn Dept, 3200 N Cramer St, Milwaukee, WI 53211 USA. [Giri, Anit] TKC Global, Herndon, VA 20171 USA. [Giri, Anit; Cho, Kyu] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD USA. [Hofmeister, Clara; Schneider, Matthew M.; Zhou, Le; Sohn, Yongho] Univ Cent Florida, Dept Mat Sci & Engn, Orlando, FL 32816 USA. [Schneider, Matthew M.; Sohn, Yongho] Univ Cent Florida, Mat Characterizat Facil, Orlando, FL 32816 USA. RP Kim, CS (reprint author), Univ Wisconsin, Mat Sci & Engn Dept, 3200 N Cramer St, Milwaukee, WI 53211 USA.; Sohn, YH (reprint author), Univ Cent Florida, Dept Mat Sci & Engn, Orlando, FL 32816 USA. EM yongho.sohn@ucf.edu; kimcs@uwm.edu RI Sohn, Yongho/A-8517-2010; OI Sohn, Yongho/0000-0003-3723-4743; Nezafati, Marjan/0000-0002-6939-0460 FU U.S. Army Research Laboratory [W911NF-15-2-0005, W911NF-11-2-0020] FX The work at UWM was supported by the U.S. Army Research Laboratory under Cooperative Agreement No. W911NF-15-2-0005. UCF authors appreciate the financial support provided by the U.S. Army Research Laboratory through Cooperative Agreement No. W911NF-11-2-0020. The views, opinions, and conclusions made in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 52 TC 1 Z9 1 U1 18 U2 24 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6454 EI 1873-2453 J9 ACTA MATER JI Acta Mater. PD AUG 15 PY 2016 VL 115 BP 295 EP 307 DI 10.1016/j.actamat.2016.06.012 PG 13 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA DR7MI UT WOS:000380083400030 ER PT J AU Klimenko, K Kuz'min, V Ognichenko, L Gorb, L Shukla, M Vinas, N Perkins, E Polishchuk, P Artemenko, A Leszczynski, J AF Klimenko, Kyrylo Kuz'min, Victor Ognichenko, Liudmila Gorb, Leonid Shukla, Manoj Vinas, Natalia Perkins, Edward Polishchuk, Pavel Artemenko, Anatoly Leszczynski, Jerzy TI Novel enhanced applications of QSPR models: Temperature dependence of aqueous solubility SO JOURNAL OF COMPUTATIONAL CHEMISTRY LA English DT Article DE QSPR; feature net; temperature-dependent; aqueous solubility ID RANDOM FOREST; SIMPLEX REPRESENTATION; PARTITION-COEFFICIENTS; MOLECULAR-STRUCTURE; DIFFERENT SOLVENTS; PREDICTION; WATER; QSAR; ETHANOL; SYSTEM AB A model developed to predict aqueous solubility at different temperatures has been proposed based on quantitative structure-property relationships (QSPR) methodology. The prediction consists of two steps. The first one predicts the value of k parameter in the linear equation lgSw=kT+c, where S-w is the value of solubility and T is the value of temperature. The second step uses Random Forest technique to create high-efficiency QSPR model. The performance of the model is assessed using cross-validation and external test set prediction. Predictive capacity of developed model is compared with COSMO-RS approximation, which has quantum chemical and thermodynamic foundations. The comparison shows slightly better prediction ability for the QSPR model presented in this publication. (c) 2016 Wiley Periodicals, Inc. C1 [Klimenko, Kyrylo; Kuz'min, Victor; Ognichenko, Liudmila; Artemenko, Anatoly] Natl Acad Sci Ukraine, Dept Mol Struct & Chemoinformat, AV Bogatsky Phys Chem Inst, Lustdorfskaya Doroga 86, UA-65080 Odessa, Ukraine. [Klimenko, Kyrylo] Univ Strasbourg, CNRS, UniStra, Lab Chemoinformat,UMR 7140, 1 Rue B Pascal, F-67000 Strasbourg, France. [Gorb, Leonid] HX5 LLC, Vichsburg, MS 39180 USA. [Shukla, Manoj; Vinas, Natalia; Perkins, Edward] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Polishchuk, Pavel] Palacky Univ, Inst Mol & Translat Med, Hnevotinska 1333-5, Olomouc 77900, Czech Republic. [Leszczynski, Jerzy] Jackson State Univ, Dept Chem, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA. RP Leszczynski, J (reprint author), Jackson State Univ, Dept Chem, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA. EM jerzy@icnanotox.org FU Environmental Quality Technology Program of the United States Army Corps of Engineers by the USAERDC; National Science Foundation from the NSF CREST Interdisciplinary Nanotoxicity Center [HRD-0833178]; National Science Foundation from the NSF CREST Interdisciplinary Nanotoxicity Center (NSF-EPSCoR) [362492-190200-01\NSFEPS-0903787]; National Science Foundation [OCI-1053575]; XSEDE [DMR110088] FX The results in this study were funded and obtained from research conducted under the Environmental Quality Technology Program of the United States Army Corps of Engineers by the USAERDC. The findings of this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents. Jerzy Leszczynski thanks the National Science Foundation for support from the NSF CREST Interdisciplinary Nanotoxicity Center (grant no. HRD-0833178; NSF-EPSCoR grant: 362492-190200-01\NSFEPS-0903787). The computation time was provided by the Extreme Science and Engineering Discovery Environment (XSEDE) by the National Science Foundation (grant no.: OCI-1053575) and XSEDE award allocation number DMR110088 and by the Mississippi Center for Supercomputer Research. Authors are thankful to Natalia Sizochenko for her contribution in model development. NR 41 TC 0 Z9 0 U1 4 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0192-8651 EI 1096-987X J9 J COMPUT CHEM JI J. Comput. Chem. PD AUG 15 PY 2016 VL 37 IS 22 BP 2045 EP 2051 DI 10.1002/jcc.24424 PG 7 WC Chemistry, Multidisciplinary SC Chemistry GA DR5KG UT WOS:000379941300001 PM 27338156 ER PT J AU Lozovskiy, A Farthing, M Kees, C Gildin, E AF Lozovskiy, Alexander Farthing, Matthew Kees, Chris Gildin, Eduardo TI POD-based model reduction for stabilized finite element approximations of shallow water flows SO JOURNAL OF COMPUTATIONAL AND APPLIED MATHEMATICS LA English DT Article DE Shallow water equations; Model reduction; Global basis; POD ID PROPER ORTHOGONAL DECOMPOSITION; COMPUTATIONAL FLUID-DYNAMICS; NONLINEAR MODEL; EMPIRICAL INTERPOLATION; EQUATIONS; SYSTEMS; FORMULATION; PROJECTION; TRANSPORT; MEDIA AB The shallow water equations (SWE) are used to model a wide range of free-surface flows from dam breaks and riverine hydrodynamics to hurricane storm surge and atmospheric processes. Despite their frequent use and improvements in algorithm and processor performance, accurate resolution of these flows is a computationally intensive task for many regimes. The resulting computational burden persists as a barrier to the inclusion of fully resolved two-dimensional shallow water models in many applications, particularly when the analysis involves optimal design, parameter inversion, risk assessment, and/or uncertainty quantification. Here, we consider model reduction for a stabilized finite element approximation of the SWE that can resolve advection-dominated problems with shocks but is also suitable for more smoothly varying riverine and estuarine flows. The model reduction is performed using Galerkin projection on a global basis provided by Proper Orthogonal Decomposition (POD). To achieve realistic speedup, we evaluate alternative techniques for the reduction of the non-polynomial nonlinearities that arise in the stabilized formulation. We evaluate the schemes' performance by considering their accuracy, robustness, and speed for idealized test problems representative of dam-break and riverine flows. (C) 2016 Elsevier B.V. All rights reserved. C1 [Lozovskiy, Alexander] Texas A&M Univ, Inst Sci Computat, College Stn, TX 77843 USA. [Farthing, Matthew; Kees, Chris] US Army Engineer Res & Dev Ctr, Coastal & Hydraul Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. [Gildin, Eduardo] Texas A&M Univ, Dept Petr Engn, College Stn, TX 77843 USA. RP Lozovskiy, A (reprint author), Texas A&M Univ, Inst Sci Computat, College Stn, TX 77843 USA. EM lozovskiy@math.tamu.edu; matthew.w.farthing@usace.army.mil; christopher.e.kees@usace.army.mil; eduardo.gildin@pe.tamu.edu OI Lozovskiy, Alexander/0000-0003-0339-2428 FU Army Research Office [W911NF-12-1-0206] FX This work has been supported by the Army Research Office through the grant No. W911NF-12-1-0206. NR 39 TC 0 Z9 0 U1 3 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0377-0427 EI 1879-1778 J9 J COMPUT APPL MATH JI J. Comput. Appl. Math. PD AUG 15 PY 2016 VL 302 BP 50 EP 70 DI 10.1016/j.cam.2016.01.029 PG 21 WC Mathematics, Applied SC Mathematics GA DK0KG UT WOS:000374601100004 ER PT J AU Watson, NE Parsons, BA Synovec, RE AF Watson, Nathanial E. Parsons, Brendon A. Synovec, Robert E. TI Performance evaluation of tile-based Fisher Ratio analysis using a benchmark yeast metabolome dataset SO JOURNAL OF CHROMATOGRAPHY A LA English DT Article DE Comprehensive; Two-dimensional; Gas chromatography; Time-of-flight mass spectrometry; Discovery-based; Metabolomics ID 2-DIMENSIONAL GAS-CHROMATOGRAPHY; FLIGHT MASS-SPECTROMETRY; GC X GC; PRINCIPAL COMPONENT ANALYSIS; RETENTION TIME ALIGNMENT; TOFMS DATA; CHEMOMETRIC ANALYSIS; FEATURE-SELECTION; TISSUE-EXTRACTS; SEPARATION DATA AB Performance of tile-based Fisher Ratio (F-ratio) data analysis, recently developed for discovery-based studies using comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry (GC x GC-TOFMS), is evaluated with a metabolomics dataset that had been previously analyzed in great detail, but while taking a brute force approach. The previously analyzed data (referred to herein as the benchmark dataset) were intracellular extracts from Saccharomyces cerevisiae (yeast), either metabolizing glucose (repressed) or ethanol (derepressed), which define the two classes in the discovery-based analysis to find metabolites that are statistically different in concentration between the two classes. Beneficially, this previously analyzed dataset provides a concrete means to validate the tile-based F-ratio software. Herein, we demonstrate and validate the significant benefits of applying tile-based F-ratio analysis. The yeast metabolomics data are analyzed more rapidly in about one week versus one year for the prior studies with this dataset. Furthermore, a null distribution analysis is implemented to statistically determine an adequate F-ratio threshold, whereby the variables with F-ratio values below the threshold can be ignored as not class distinguishing, which provides the analyst with confidence when analyzing the hit table. Forty-six of the fifty-four benchmarked changing metabolites were discovered by the new methodology while consistently excluding all but one of the benchmarked nineteen false positive metabolites previously identified. (C) 2016 Elsevier B.V. All rights reserved. C1 [Watson, Nathanial E.; Parsons, Brendon A.; Synovec, Robert E.] Univ Washington, Dept Chem, Box 351700, Seattle, WA 98195 USA. [Watson, Nathanial E.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. RP Synovec, RE (reprint author), Univ Washington, Dept Chem, Box 351700, Seattle, WA 98195 USA. EM synovec@chem.washington.edu OI Parsons, Brendon/0000-0002-4411-0063 NR 40 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0021-9673 EI 1873-3778 J9 J CHROMATOGR A JI J. Chromatogr. A PD AUG 12 PY 2016 VL 1459 BP 101 EP 111 DI 10.1016/j.chroma.2016.06.067 PG 11 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA DT0IH UT WOS:000381166700011 PM 27393630 ER PT J AU Hu, Y Shaw, AP Estes, DP Norton, JR AF Hu, Yue Shaw, Anthony P. Estes, Deven P. Norton, Jack R. TI Transition-Metal Hydride Radical Cations SO CHEMICAL REVIEWS LA English DT Review ID CATALYZED IONIC HYDROGENATION; BOND-DISSOCIATION ENERGIES; ONE-ELECTRON OXIDATION; H-CENTER-DOT; ELECTROCHEMICAL OXIDATION; CRYSTAL-STRUCTURE; POLYHYDRIDE COMPLEXES; DIHYDROGEN COMPLEX; RHODIUM CLUSTERS; CHAIN TRANSFER AB Transition-metal hydride radical cations (TMHRCs) are involved in a variety of chemical and biochemical reactions, making a more thorough understanding of their properties essential for explaining observed reactivity and for the eventual development of new applications. Generally, these species may be treated as the ones formed by one-electron oxidation of diamagnetic analogues that are neutral or cationic. Despite the importance of TMHRCs, the generally sensitive nature of these complexes has hindered their development. However, over the last four decades, many more TMHRCs have been synthesized, characterized, isolated, or hypothesized as reaction intermediates. This comprehensive review focuses on experimental studies of TMHRCs reported through the year 2014, with an emphasis on isolated and observed species. The methods used for the generation or synthesis of TMHRCs are surveyed, followed by a discussion about the stability of these complexes. The fundamental properties of TMHRCs, especially those pertaining to the M-H bond, are described, followed by a detailed treatment of decomposition pathways. Finally, reactions involving TMHRCs as intermediates are described. C1 [Hu, Yue; Estes, Deven P.; Norton, Jack R.] Columbia Univ, Dept Chem, New York, NY 10027 USA. [Shaw, Anthony P.] US Army, Pyrotech Technol & Prototyping Div, RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA. [Hu, Yue] Eastman Chem Co, Kingsport, TN 37660 USA. [Estes, Deven P.] ETH, Inorgan Chem Lab, CH-8093 Zurich, Switzerland. RP Hu, Y; Norton, JR (reprint author), Columbia Univ, Dept Chem, New York, NY 10027 USA.; Hu, Y (reprint author), Eastman Chem Co, Kingsport, TN 37660 USA. EM hyue2468@gmail.com; jrn11@columbia.edu FU NSF [CHE-0749537]; Boulder Scientific; OFS Fitel; Department of Energy Office of Science Graduate Fellowship Program (DOE SCGF); American Recovery and Reinvestment Act; ORISE-ORAU [DE-AC05-06OR23100] FX The completion of this article was supported by NSF Grant CHE-0749537, Boulder Scientific, and OFS Fitel. D.P.E. was supported by the Department of Energy Office of Science Graduate Fellowship Program (DOE SCGF), made possible in part by the American Recovery and Reinvestment Act of 2009 and administered by ORISE-ORAU under Contract DE-AC05-06OR23100. NR 139 TC 5 Z9 5 U1 25 U2 31 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0009-2665 EI 1520-6890 J9 CHEM REV JI Chem. Rev. PD AUG 10 PY 2016 VL 116 IS 15 BP 8427 EP 8462 DI 10.1021/acs.chemrev.5b00532 PG 36 WC Chemistry, Multidisciplinary SC Chemistry GA DT2SZ UT WOS:000381332000004 PM 26828562 ER PT J AU Delp, SA Borodin, O Olguin, M Eisner, CG Allen, JL Jow, TR AF Delp, Samuel A. Borodin, Oleg Olguin, Marco Eisner, Claire G. Allen, Joshua L. Jow, T. Richard TI Importance of Reduction and Oxidation Stability of High Voltage Electrolytes and Additives SO ELECTROCHIMICA ACTA LA English DT Article DE lithium battery; electrolyte; quantum chemistry; density functional theory; reduction; oxidation ID LITHIUM-ION BATTERIES; FLUORINATED ELECTROLYTES; CATHODE MATERIALS; QUANTUM-CHEMISTRY; GRAPHITE/ELECTROLYTE INTERFACE; ELECTROCHEMICAL OXIDATION; NONAQUEOUS ELECTROLYTES; INDUCED DECOMPOSITION; PROPYLENE CARBONATE; ETHYLENE CARBONATE AB The electrolyte is a critical component for rechargeable Li-ion batteries, especially batteries containing high voltage cathodes. A series of electrolyte salts, solvents and additives was investigated via cyclic voltammetry (CV) on glassy carbon (GC) electrodes. Quantum chemistry (QC) calculations were used for prediction of oxidation and reduction stability of electrolyte components such as ethylene carbonate (EC), dimethyl carbonate (DMC), fluoroethylene carbonate (FEC), vinylene carbonate (VC), tris (trimethylsilyl) phosphate (TMSP), 1,3-propane sultone (PS), tris(hexafluoroisopropyl) phosphate (HFiPP) and lithium salts such as LiPF6, LiBF4, lithium difluoro(oxalato) borate (LiDFOB), lithium 4,5-dicyano-2-trifluoromethyl-imidazolide (LiTDI), and lithium bis(trifluoromethanesulfonimide) (LiTFSI). QC calculations predicted that defluorination of LiPF6 and LiTFSI aggregates coupled with electron transfer significantly increased their reduction potential, while H-transfer upon oxidation lowered oxidation potential for many solvents. The composition of the Li+ cation solvation shell was estimated from the binding energies for the Li+-solvent complexes using cluster-continuum calculations and was used to provide insight into the experimental data on electrolyte reduction. Full coin cell data was acquired using LiNi0.5Mn1.5O4 (LNMO) cathodes with graphite anodes at 25 degrees C and 55 degrees C. Differential capacity plots (dQ/dE vs. E) and electrochemical impedance spectroscopy (EIS) results. The electrolyte with the most desirable performance was 1 M LiPF6 in 3:7 EC:EMC (wt%) with 1 wt% TMSP. Oxidative CV experiments show that the TMSP containing electrolyte has a slightly lower oxidation stability compared to the baseline, which is consistent with the order of oxidation stability of electrolyte components from QC calculations. The EIS measurements showed that the TMSP containing electrolyte had the lowest impedance after cycling and the dQ/dE plots show that the redox reactions retained their peak shape and area more so than an electrolyte without TMSP, indicating a greater capacity retention. Density functional theory calculations of TMSP oxidation on the LNMO surface were performed in order to provide insight into the additive role in improving cell performance. Published by Elsevier Ltd. C1 [Delp, Samuel A.; Borodin, Oleg; Olguin, Marco; Allen, Joshua L.; Jow, T. Richard] US Army, Electrochem Branch, Res Lab, Adelphi, MD 20783 USA. [Eisner, Claire G.] US Army, Res Lab, Simulat Sci Branch, Aberdeen Proving Ground, MD 21005 USA. RP Delp, SA (reprint author), US Army, Electrochem Branch, Res Lab, Adelphi, MD 20783 USA. EM samuel.delp.ctr@mail.mil; oleg.a.borodin.civ@mail.mil FU Army Research Laboratory postdoctoral program administered through Oak Ridge Associated Universities; ARL Enterprise for Multiscale Research FX SAD and MO were funded by the Army Research Laboratory postdoctoral program administered through Oak Ridge Associated Universities. Modeling work was supported by ARL Enterprise for Multiscale Research. NR 55 TC 6 Z9 6 U1 65 U2 113 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0013-4686 EI 1873-3859 J9 ELECTROCHIM ACTA JI Electrochim. Acta PD AUG 10 PY 2016 VL 209 BP 498 EP 510 DI 10.1016/j.electacta.2016.05.100 PG 13 WC Electrochemistry SC Electrochemistry GA DQ9BE UT WOS:000379504600056 ER PT J AU Cole, DP Riddick, JC Jaim, HMI Strawhecker, KE Zander, NE AF Cole, Daniel P. Riddick, Jaret C. Jaim, H. M. Iftekhar Strawhecker, Kenneth E. Zander, Nicole E. TI Interfacial mechanical behavior of 3D printed ABS SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article DE mechanical properties; properties and characterization; structure-property relations; viscosity and viscoelasticity ID DEPTH-SENSING INDENTATION; FUSED DEPOSITION; INSTRUMENTED INDENTATION; NANOMECHANICAL CHARACTERIZATION; VISCOELASTIC CHARACTERIZATION; ELASTIC-MODULUS; POLYMERS; NANOINDENTATION; RHEOLOGY; PARTS AB We describe an experimental approach for characterizing the local mechanical behavior of acrylonitrile butadiene styrene (ABS) structures processed through fused deposition modeling. ABS test specimens processed in various build orientations were subject to multiscale mechanical tests as well as local morphology and chemical analyses. Instrumented indentation, local dynamic mechanical analysis, and atomic force microscopy tests were used to explore the mechanical behavior and morphology of build surfaces and weld interfaces. An interfacial stiffening effect was found for the majority of the specimens tested, with up to a 40% increase in the indentation elastic modulus measured with respect to the build surfaces. Raman spectroscopy mapping of the interfacial areas revealed approximate to 30% less butadiene/styrene and butadiene/acrylonitrile ratios with respect to analysis of the build surfaces. The results provide insight into the multiscale behavior of additive manufactured structures and offer the potential to guide processing-structure-property understanding of these materials. (c) 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43671. C1 [Cole, Daniel P.; Riddick, Jaret C.] US Army, Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA. [Jaim, H. M. Iftekhar] Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA. [Strawhecker, Kenneth E.; Zander, Nicole E.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Cole, DP (reprint author), US Army, Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA. EM daniel.p.cole.ctr@mail.mil NR 41 TC 0 Z9 0 U1 30 U2 143 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0021-8995 EI 1097-4628 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD AUG 10 PY 2016 VL 133 IS 30 AR 43671 DI 10.1002/app.43671 PG 12 WC Polymer Science SC Polymer Science GA DM3QU UT WOS:000376262100012 ER PT J AU Pirarat, N Sahatrakul, K Lacharoje, S Lombardini, E Chansue, N Techangamsuwan, S AF Pirarat, Nopadon Sahatrakul, Komsil Lacharoje, Sitthichok Lombardini, Eric Chansue, Nantarika Techangamsuwan, Somporn TI Molecular and pathological characterization of Fusarium solani species complex infection in the head and lateral line system of Sphyrna lewini SO DISEASES OF AQUATIC ORGANISMS LA English DT Article DE Fusarium solani species complex 2; Invasive fusariosis; Lateral line system; Sphyrna lewini ID HAMMERHEAD SHARKS; FUNGAL-INFECTION; SPECTRUM AB A severe fungal infection affecting the head and lateral line system was diagnosed in 7 captive scalloped hammerhead sharks Sphyrna lewini in an aquarium in Thailand. Extensive and severe necrotizing cellulitis was consistently observed microscopically along the cephalic and lateral line canals in conjunction with positive fungal cultures for Fusarium sp. Molecular phylogenetic analysis was performed from 3 isolates based on the nucleotide sequences containing internally transcribed spacer (ITS) and a portion of 5.8S and 28S rDNA. The fungus was highly homologous (100%) and closely related to F. solani species complex 2 (FSSC 2), which belongs to Clade 3 of the FSSC. Our results illustrate the histopathological findings and expand upon our knowledge of the prevalence of invasive fusariosis in the head and lateral line system of hammerhead sharks. C1 [Pirarat, Nopadon; Lacharoje, Sitthichok; Techangamsuwan, Somporn] Chulalongkorn Univ, Fac Vet Sci, Dept Pathol, STAR Wildlife Exot & Aquat Pathol, Bangkok 10330, Thailand. [Sahatrakul, Komsil; Chansue, Nantarika] Chulalongkorn Univ, Fac Vet Sci, Dept Vet Med, Bangkok 10330, Thailand. [Lombardini, Eric] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Techangamsuwan, Somporn] Chulalongkorn Univ, Fac Vet Sci, Ctr Emerging & Reemerging Infect Dis Anim CUEIDAs, Bangkok 10330, Thailand. RP Techangamsuwan, S (reprint author), Chulalongkorn Univ, Fac Vet Sci, Dept Pathol, STAR Wildlife Exot & Aquat Pathol, Bangkok 10330, Thailand.; Techangamsuwan, S (reprint author), Chulalongkorn Univ, Fac Vet Sci, Ctr Emerging & Reemerging Infect Dis Anim CUEIDAs, Bangkok 10330, Thailand. EM somporn62@hotmail.com FU Faculty of Veterinary Science, Chulalongkorn University [RG20/2556]; Chulalongkorn University FX We thank Norasate Jeakpapornhirun, Torrung Vetchapitak, Phimnipha Siriwattanakul, and Apichaya Ratatanamongkolmas for laboratory assistance. We declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. E.D.L. is a Lieutenant Colonel in the US Army. The opinions or assertions herein are those of the authors and do not necessarily reflect the view of the Department of the Army or the Department of Defense. We received financial support for the research from the Faculty of Veterinary Science, Chulalongkorn University (RG20/2556), and for publication from Chulalongkorn University. NR 26 TC 0 Z9 0 U1 2 U2 2 PU INTER-RESEARCH PI OLDENDORF LUHE PA NORDBUNTE 23, D-21385 OLDENDORF LUHE, GERMANY SN 0177-5103 EI 1616-1580 J9 DIS AQUAT ORGAN JI Dis. Aquat. Org. PD AUG 9 PY 2016 VL 120 IS 3 BP 195 EP 204 DI 10.3354/dao03028 PG 10 WC Fisheries; Veterinary Sciences SC Fisheries; Veterinary Sciences GA DV9JL UT WOS:000383256600003 PM 27503915 ER PT J AU Wallqvist, A Fang, X Tewari, SG Ye, P Reifman, J AF Wallqvist, Anders Fang, Xin Tewari, Shivendra G. Ye, Ping Reifman, Jaques TI Metabolic host responses to malarial infection during the intraerythrocytic developmental cycle SO BMC SYSTEMS BIOLOGY LA English DT Article DE Host-pathogen interactions; Plasmodium falciparum; Metabolism; Intraerythrocytic developmental cycle; Gene expression data; Oxidative stress response ID PARASITE PLASMODIUM-FALCIPARUM; DRUG TARGETS; GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCY; ERYTHROCYTE METABOLISM; NETWORK; GROWTH; GLYCOLYSIS; TRANSPORT; CELL; RECONSTRUCTION AB Background: The malarial parasite Plasmodium falciparum undergoes a complex life cycle, including an intraerythrocytic developmental cycle, during which it is metabolically dependent on the infected human red blood cell (RBC). To describe whole cell metabolic activity within both P. falciparum and RBCs during the asexual reproduction phase of the intraerythrocytic developmental cycle, we developed an integrated host-parasite metabolic modeling framework driven by time-dependent gene expression data. Results: We validated the model by reproducing the experimentally determined 1) stage-specific production of biomass components and their precursors in the parasite and 2) metabolite concentration changes in the medium of P. falciparum-infected RBC cultures. The model allowed us to explore time-and strain-dependent P. falciparum metabolism and hypothesize how host cell metabolism alters in response to malarial infection. Specifically, the metabolic analysis showed that uninfected RBCs that coexist with infected cells in the same culture decrease their production of 2,3-bisphosphoglycerate, an oxygen-carrying regulator, reducing the ability of hemoglobin in these cells to release oxygen. Furthermore, in response to parasite-induced oxidative stress, infected RBCs downgraded their glycolytic flux by using the pentose phosphate pathway and secreting ribulose-5-phosphate. This mechanism links individually observed experimental phenomena, such as glycolytic inhibition and ribulose-5-phosphate secretion, to the oxidative stress response. Conclusions: Although the metabolic model does not incorporate regulatory mechanisms per se, alterations in gene expression levels caused by regulatory mechanisms are manifested in the model as altered metabolic states. This provides the model the capability to capture complex multicellular host-pathogen metabolic interactions of the infected RBC culture. The system-level analysis revealed complex relationships such as how the parasite can reduce oxygen release in uninfected cells in the presence of infected RBCs as well as the role of different metabolic pathways involved in the oxidative stress response of infected RBCs. C1 [Wallqvist, Anders; Fang, Xin; Tewari, Shivendra G.; Ye, Ping; Reifman, Jaques] US Army Med Res & Mat Command, Dept Def Biotechnol, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. RP Reifman, J (reprint author), US Army Med Res & Mat Command, Dept Def Biotechnol, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. EM jaques.reifman.civ@mail.mil FU U.S. Army Medical Research and Materiel Command (Ft. Detrick, MD) as part of the U.S. Army's Network Science Initiative FX This work was supported by the U.S. Army Medical Research and Materiel Command (Ft. Detrick, MD) as part of the U.S. Army's Network Science Initiative. NR 45 TC 1 Z9 1 U1 1 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1752-0509 J9 BMC SYST BIOL JI BMC Syst. Biol. PD AUG 8 PY 2016 VL 10 AR 58 DI 10.1186/s12918-016-0291-2 PG 18 WC Mathematical & Computational Biology SC Mathematical & Computational Biology GA DS6FW UT WOS:000380878400002 PM 27502771 ER PT J AU Nelson, DA Deuster, PA Carter, R Hill, OT Wolcott, VL Kurina, LM AF Nelson, D. Alan Deuster, Patricia A. Carter, Robert, III Hill, Owen T. Wolcott, Vickee L. Kurina, Lianne M. TI Sickle Cell Trait, Rhabdomyolysis, and Mortality among US Army Soldiers SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID ACUTE-RENAL-FAILURE; SUDDEN-DEATH; FATAL RHABDOMYOLYSIS; RISK-FACTOR; EXERTION; RECRUITS; FORCES AB BACKGROUND Studies have suggested that sickle cell trait elevates the risks of exertional rhabdomyolysis and death. We conducted a study of sickle cell trait in relation to these outcomes, controlling for known risk factors for exertional rhabdomyolysis, in a large population of active persons who had undergone laboratory tests for hemoglobin AS (HbAS) and who were subject to exertional-injury precautions. METHODS We used Cox proportional-hazards models to test whether the risks of exertional rhabdomyolysis and death varied according to sickle cell trait status among 47,944 black soldiers who had undergone testing for HbAS and who were on active duty in the U.S. Army between January 2011 and December 2014. We used the Stanford Military Data Repository, which contains comprehensive medical and administrative data on all active-duty soldiers. RESULTS There was no significant difference in the risk of death among soldiers with sickle cell trait, as compared with those without the trait (hazard ratio, 0.99; 95% confidence interval [CI], 0.46 to 2.13; P = 0.97), but the trait was associated with a significantly higher adjusted risk of exertional rhabdomyolysis (hazard ratio, 1.54; 95% CI, 1.12 to 2.12; P = 0.008). This effect was similar in magnitude to that associated with tobacco use, as compared with no use (hazard ratio, 1.54; 95% CI, 1.23 to 1.94; P<0.001), and to that associated with having a body-mass index (BMI; the weight in kilograms divided by the square of the height in meters) of 30.0 or more, as compared with a BMI of less than 25.0 (hazard ratio, 1.39; 95% CI, 1.04 to 1.86; P = 0.03). The effect was less than that associated with recent use of a statin, as compared with no use (hazard ratio, 2.89; 95% CI, 1.51 to 5.55; P = 0.001), or an antipsychotic agent (hazard ratio, 3.02; 95% CI, 1.34 to 6.82; P = 0.008). CONCLUSIONS Sickle cell trait was not associated with a higher risk of death than absence of the trait, but it was associated with a significantly higher risk of exertional rhabdomyolysis. C1 [Nelson, D. Alan; Kurina, Lianne M.] Stanford Univ, Sch Med, Dept Med, 450 Serra Mall,Bldg 20, Stanford, CA 94305 USA. [Deuster, Patricia A.] Uniformed Serv Univ Hlth Sci, Consortium Hlth & Mil Performance, Dept Def Ctr Excellence, Bethesda, MD 20814 USA. [Deuster, Patricia A.] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD 20814 USA. [Carter, Robert, III] US Army Inst Surg Res, Ft Sam Houston, TX USA. [Hill, Owen T.] Brooke Army Med Ctr, Extrem Trauma & Amputat Ctr Excellence, Ctr Intrepid, Ft Sam Houston, TX 78234 USA. [Wolcott, Vickee L.] Army Baylor Univ, Grad Program Hlth & Business Adm, Ft Sam Houston, TX USA. [Carter, Robert, III] Univ Texas Hlth Sci Ctr San Antonio, Dept Emergency Med, San Antonio, TX 78229 USA. RP Kurina, LM (reprint author), Stanford Univ, Sch Med, Dept Med, 450 Serra Mall,Bldg 20, Stanford, CA 94305 USA. EM lkurina@stanford.edu FU National Heart, Lung, and Blood Institute; Uniformed Services University of the Health Sciences FX Funded by the National Heart, Lung, and Blood Institute and the Uniformed Services University of the Health Sciences. NR 37 TC 5 Z9 5 U1 3 U2 4 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD AUG 4 PY 2016 VL 375 IS 5 BP 435 EP 442 DI 10.1056/NEJMoa1516257 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA DS7AN UT WOS:000380934900007 PM 27518662 ER PT J AU Hirschtritt, ME Darrow, SM Illmann, C Osiecki, L Grados, M Sandor, P Dion, Y King, RA Pauls, DL Budman, CL Cath, DC Greenberg, E Lyon, GJ Yu, DM McGrath, LM McMahon, WM Lee, PC Delucchi, KL Scharf, JM Mathews, CA AF Hirschtritt, Matthew E. Darrow, Sabrina M. Illmann, Cornelia Osiecki, Lisa Grados, Marco Sandor, Paul Dion, Yves King, Robert A. Pauls, David L. Budman, Cathy L. Cath, Danielle C. Greenberg, Erica Lyon, Gholson J. Yu, Dongmei McGrath, Lauren M. McMahon, William M. Lee, Paul C. Delucchi, Kevin L. Scharf, Jeremiah M. Mathews, Carol A. CA TSAICG TI Social disinhibition is a heritable subphenotype of tics in Tourette syndrome SO NEUROLOGY LA English DT Article ID OBSESSIVE-COMPULSIVE DISORDER; SYMPTOM DIMENSIONS; COMPONENTS; NUMBER; MODEL; PAIR AB Objective: To identify heritable symptom-based subtypes of Tourette syndrome (TS). Methods: Forty-nine motor and phonic tics were examined in 3,494 individuals (1,191 TS probands and 2,303 first-degree relatives). Item-level exploratory factor and latent class analyses (LCA) were used to identify tic-based subtypes. Heritabilities of the subtypes were estimated, and associations with clinical characteristics were examined. Results: A 6-factor exploratory factor analysis model provided the best fit, which paralleled the somatotopic representation of the basal ganglia, distinguished simple from complex tics, and separated out socially disinhibited and compulsive tics. The 5-class LCA model best distinguished among the following groups: unaffected, simple tics, intermediate tics without social disinhibition, intermediate with social disinhibition, and high rates of all tic types. Across models, a phenotype characterized by high rates of social disinhibition emerged. This phenotype was associated with increased odds of comorbid psychiatric disorders, in particular, obsessive-compulsive disorder and attention-deficit/hyperactivity disorder, earlier age at TS onset, and increased tic severity. The heritability estimate for this phenotype based on the LCA was 0.53 (SE 0.08, p 1.7 X 10(-18)). Conclusions: Expanding on previous modeling approaches, a series of TS-related phenotypes, including one characterized by high rates of social disinhibition, were identified. These phenotypes were highly heritable and may reflect underlying biological networks more accurately than traditional diagnoses, thus potentially aiding future genetic, imaging, and treatment studies. C1 [Hirschtritt, Matthew E.; Darrow, Sabrina M.; Delucchi, Kevin L.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA. [Illmann, Cornelia; Osiecki, Lisa; Pauls, David L.; Greenberg, Erica; Yu, Dongmei; Scharf, Jeremiah M.] Harvard Med Sch, Massachusetts Gen Hosp, Psychiat & Neurodevel Genet Unit, Ctr Human Genet Res,Dept Psychiat, Boston, MA USA. [Grados, Marco] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA. [Sandor, Paul] Univ Toronto, Dept Psychiat, Toronto, ON M5S 1A1, Canada. Univ Hlth Network, Youthdale Treatment Ctr, Toronto, ON, Canada. [Dion, Yves] Univ Montreal, Dept Psychiat, Montreal, PQ H3C 3J7, Canada. [King, Robert A.] Yale Univ, Sch Med, Yale Child Study Ctr, New Haven, CT USA. [Budman, Cathy L.] North Shore Long Isl Jewish Hlth Syst, Feinstein Inst Med Res, Manhasset, NY USA. [Cath, Danielle C.] Univ Utrecht, Fac Social & Behav Sci, Utrecht, Netherlands. Altrecht Acad Anxiety Ctr, Utrecht, Netherlands. [Lyon, Gholson J.] Cold Spring Harbor Lab, Stanley Inst Cognit Genom, POB 100, Cold Spring Harbor, NY 11724 USA. [McGrath, Lauren M.] Amer Univ, Sch Educ, Washington, DC 20016 USA. [McMahon, William M.] Univ Utah, Dept Psychiat, Salt Lake City, UT USA. [Lee, Paul C.] Tripler Army Med Ctr, Dept Behav Hlth, Honolulu, HI 96859 USA. [Scharf, Jeremiah M.] Harvard Med Sch, Brigham & Womens Hosp, Div Cognit & Behav Neurol, Boston, MA USA. [Scharf, Jeremiah M.] Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Boston, MA USA. [Mathews, Carol A.] Univ Florida, Dept Psychiat, Gainesville, FL 32611 USA. RP Mathews, CA (reprint author), Univ Florida, Dept Psychiat, Gainesville, FL 32611 USA. EM carolmathews@ufl.edu FU NIH [R01MH096767, U01NS040024, K23MH085057, K02MH00508, R01NS016648]; Tourette Syndrome Association FX This work was supported by the NIH, grants R01MH096767 ("Refining the Tourette syndrome phenotype across diagnoses to aid gene discovery," principal investigator [PI]: Carol Mathews), U01NS040024 ("A genetic linkage study of GTS," PI: David Pauls/Jeremiah Scharf), K23MH085057 ("Translational phenomics and genomics of Gilles de la Tourette syndrome," PI: Jeremiah Scharf), K02MH00508 ("Genetics of a behavioral disorder: Tourette syndrome," PI: David Pauls), and R01NS016648 ("A genetic study of GTS, OCD, and ADHD," PI: David Pauls), and from the Tourette Syndrome Association. These funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. None of the funding agencies for this project (NINDS, NIMH, the Tourette Syndrome Association) had any influence or played any role in (1) the design or conduct of the study; (2) management, analysis, or interpretation of the data; (3) preparation, review, or approval of the manuscript. The views expressed in this publication are those of the authors and do not reflect the official policy or position of the Department of the Army, Department of Defense, or the US Government. NR 28 TC 2 Z9 2 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0028-3878 EI 1526-632X J9 NEUROLOGY JI Neurology PD AUG 2 PY 2016 VL 87 IS 5 BP 497 EP 504 PG 8 WC Clinical Neurology SC Neurosciences & Neurology GA DU6LO UT WOS:000382326500014 PM 27371487 ER PT J AU Anderson, KB Thomas, SJ Endy, TP AF Anderson, Kathryn B. Thomas, Stephen J. Endy, Timothy P. TI The Emergence of Zika Virus A Narrative Review SO ANNALS OF INTERNAL MEDICINE LA English DT Review ID GUILLAIN-BARRE-SYNDROME; ENROLLING PREGNANT-WOMEN; SEXUAL TRANSMISSION; CLINICAL-RESEARCH; POTENTIAL VECTOR; UNITED-STATES; DENGUE-FEVER; INFECTION; BRAZIL; MOSQUITOS AB Zika virus (ZIKV) is yet another arbovirus that is rapidly emerging on a global scale, on the heels of a chikungunya epidemic in the Americas that began in 2013. A ZIKV epidemic that began in Brazil in 2015 has now spread rapidly to more than 30 countries in the Americas and the Caribbean, infecting more than 2 million inhabitants. This epidemic currently continues unabated. The explosive nature of recent outbreaks and concerning links to Guillain-Barre syndrome and microcephaly are incompletely understood. Also unknown is the relative importance of sexual transmission of ZIKV and asymptomatic ZIKV infections to the overall burden of transmission. The limited understanding of ZIKV presents an enormous challenge for responses to this rapidly emerging threat to human health. This article reviews the existing literature on ZIKV and proposes critical questions for vaccine development and other areas of needed research. C1 Univ Minnesota, Minneapolis, MN USA. Walter Reed Army Inst Res, US Army Med Directorate, Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Thomas, Stephen J.] Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. SUNY Upstate Med Univ, Syracuse, NY 13210 USA. [Anderson, Kathryn B.] Univ Minnesota, Dept Med, MMC 741,Mayo Bldg, Minneapolis, MN 55455 USA. [Endy, Timothy P.] SUNY Upstate Med Univ, Div Infect Dis, 750 East Adams St,CPOB Suite 304, Syracuse, NY 13210 USA. RP Anderson, KB (reprint author), Univ Minnesota, Dept Med, MMC 741,Mayo Bldg, Minneapolis, MN 55455 USA. EM ande7622@umn.edu NR 76 TC 10 Z9 10 U1 20 U2 73 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 USA SN 0003-4819 EI 1539-3704 J9 ANN INTERN MED JI Ann. Intern. Med. PD AUG 2 PY 2016 VL 165 IS 3 BP 175 EP + DI 10.7326/M16-0617 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA DS2HA UT WOS:000380583300006 PM 27135717 ER PT J AU Alving, CR Matyas, G Beck, Z Rao, M AF Alving, Carl R. Matyas, Gary Beck, Zoltan Rao, Mangala TI LIPOSOMAL VACCINE ADJUVANT FORMULATIONS SO REVUE ROUMAINE DE CHIMIE LA English DT Article ID MONOPHOSPHORYL-LIPID-A; INOSITOL HEXAPHOSPHATE; O2 RELEASE; EFFICACY; SYSTEM; SAFE; MICE AB Liposomes known as Army Liposome Formulation (ALF), which are used as a potent vaccine adjuvant formulation, have a lipid bilayer bulk composed of phospholipids, usually dimyristoyl phosphatidylcholine and dimyristoyl phosphatidylglycerol, in which the hydrocarbon chains have a melting temperature in water of >= 23 degrees C. Cholesterol is present in the bilayer as a stabilizer, and monophosphoryl lipid A (MPLA) as an immunostimulator. Using synthetic congeners of MPLA we demonstrate that with ALF liposomes containing a cholesterol-binding saponin as an additional adjuvant, differences in the number and placement of 14-carbon hydrocarbon chains attached to the diglucosamine phosphate headgroup of the MPLA do not significantly impact the magnitude of the immune response to an HIV-1 envelope protein. C1 [Alving, Carl R.; Matyas, Gary; Beck, Zoltan; Rao, Mangala] US Mil HIV Res Program, Walter Reed Army Inst Res, Lab Adjuvant & Antigen Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. [Beck, Zoltan] US Mil HIV Res Program, Henry M Jackson Fdn Adv Mil Med, 6720A Rockledge Dr, Bethesda, MD 20817 USA. RP Alving, CR (reprint author), US Mil HIV Res Program, Walter Reed Army Inst Res, Lab Adjuvant & Antigen Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM calving@hivresearch.org FU Henry M. Jackson Foundation for the Advancement of Military Medicine [W81XWH-07-2-067]; U.S. Army Medical Research and Materiel Command (MRMC) [W81XWH-07-2-067] FX This paper is dedicated to Professor Claude Nicolau on the occasion of his 80th birthday. This work was supported through a Cooperative Agreement Award (no.W81XWH-07-2-067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the U.S. Army Medical Research and Materiel Command (MRMC). The views expressed in this article are those of the authors and do not necessarily reflect the official policy of the Department of the Army, Department of Defense, or the U.S. Government. NR 14 TC 0 Z9 0 U1 0 U2 0 PU EDITURA ACAD ROMANE PI BUCURESTI PA CALEA 13 SEPTEMBRIE NR 13, SECTOR 5, BUCURESTI 050711, ROMANIA SN 0035-3930 J9 REV ROUM CHIM JI Rev. Roum. Chim. PD AUG-SEP PY 2016 VL 61 IS 8-9 BP 631 EP 635 PG 5 WC Chemistry, Multidisciplinary SC Chemistry GA EF8YQ UT WOS:000390618300003 ER PT J AU Sloan, SD Schwenk, JT Stevens, RH AF Sloan, Steven D. Schwenk, J. Tyler Stevens, Robert H. TI An example of extreme near-surface variability in shallow seismic reflection data SO INTERPRETATION-A JOURNAL OF SUBSURFACE CHARACTERIZATION LA English DT Article ID DEPTH CHARACTERIZATION; BEDROCK SURFACE; AQUIFERS; ALLUVIUM AB Variability of material properties in the shallow subsurface presents challenges for near-surface geophysical methods and exploration-scale applications. As the depth of investigation decreases, denser sampling is required, especially of the near offsets, to accurately characterize the shallow subsurface. We have developed a field data example using high-resolution shallow seismic reflection data to demonstrate how quickly near-surface properties can change over short distances and the effects on field data and processed sections. The addition of a relatively thin, 20 cm thick, low-velocity layer can lead to masked reflections and an inability to map shallow reflectors. Short receiver intervals, on the order of 10 cm, were necessary to identify the cause of the diminished data quality and would have gone unknown using larger, more conventional station spacing. Combined analysis of first arrivals, surface waves, and reflections aided in determining the effects and extent of a low-velocity layer that inhibited the identification and constructive stacking of the reflection from a shallow water table using normal-moveout-based processing methods. Our results also highlight the benefits of using unprocessed gathers to pragmatically guide processing and interpretation of seismic data. C1 [Sloan, Steven D.] US Army Engineer Res & Dev Ctr, Vicksburg, MS USA. [Schwenk, J. Tyler; Stevens, Robert H.] XRI Geophys, Vicksburg, MS USA. RP Sloan, SD (reprint author), US Army Engineer Res & Dev Ctr, Vicksburg, MS USA. EM steven.d.sloan@usace.army.mil; tyler.schwenk@xrigeo.com; robert.stevens@xrigeo.com FU Office of Science (BER), U.S. Department of Energy (DOE) [DE-FG02-03ER63656] FX The authors wish to thank P. Vincent, R. Eslick, G. Czarnecki, and G. Tsoflias for their time in the field. This research was supported by the Office of Science (BER), U.S. Department of Energy (DOE), grant no. DE-FG02-03ER63656. However, any opinions, conclusions, or recommendations expressed herein are those of the authors and do not necessarily reflect the views of the DOE. Permission to publish this paper was granted by the director of the Geotechnical and Structures Laboratory, U.S. Army Engineer Research and Development Center. NR 24 TC 1 Z9 1 U1 0 U2 0 PU SOC EXPLORATION GEOPHYSICISTS PI TULSA PA 8801 S YALE ST, TULSA, OK 74137 USA SN 2324-8858 EI 2324-8866 J9 INTERPRETATION-J SUB JI Interpretation PD AUG PY 2016 VL 4 IS 3 BP SH1 EP SH9 DI 10.1190/INT-2015-0215.1 PG 9 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA ED4OC UT WOS:000388828000028 ER PT J AU Taylor, S Lever, JH Alexander, CMO Brownlee, DE Messenger, S Nittler, LR Stroud, RM Wozniakiewicz, P Clemett, S AF Taylor, S. Lever, J. H. Alexander, C. M. O'D Brownlee, D. E. Messenger, S. Nittler, L. R. Stroud, R. M. Wozniakiewicz, P. Clemett, S. TI SAMPLING INTERPLANETARY DUST PARTICLES FROM ANTARCTIC AIR. SO METEORITICS & PLANETARY SCIENCE LA English DT Meeting Abstract CT 79th Annual Meeting of the Meteoritical-Society CY AUG 07-12, 2016 CL Berlin, GERMANY SP Meteorit Soc ID MICROMETEORITES; GRAINS; SNOW C1 [Taylor, S.; Lever, J. H.] CRREL, 72 Lyme Rd, Hanover, NH 03755 USA. [Alexander, C. M. O'D; Nittler, L. R.] Carnegie Inst Sci, 5241 Broad Branch Rd NW, Washington, DC 20015 USA. [Brownlee, D. E.] Univ Washington, Dept Astron, Seattle, WA 91195 USA. [Messenger, S.; Clemett, S.] NASA, Johnson Space Ctr, ARES, Code SR, Houston, TX 77058 USA. [Stroud, R. M.] Naval Res Lab, Mat Sci & Technol Div, Washington, DC 20375 USA. [Wozniakiewicz, P.] Univ Kent, Sch Phys Sci, Ingram Bldg, Canterbury CT2 7NH, Kent, England. EM Susan.Taylor@erdc.dren.mil; James.Lever@erdc.dren.mil; alexande@dtm.ciw.edu; browlee@astro.washington.edu; scott.messenger@nasa.gov; lnit-tler@ciw.edu; stroud@nrl.navy.mil; pjw@kent.ac.uk; simon.j.clemett@nasa.gov NR 10 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1086-9379 EI 1945-5100 J9 METEORIT PLANET SCI JI Meteorit. Planet. Sci. PD AUG PY 2016 VL 51 SU 1 SI SI BP A618 EP A618 PG 1 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA ED2GQ UT WOS:000388662400476 ER PT J AU Moser, RP Pace, ME AF Moser, Richard P., III Pace, Maria Elena TI 10-Pound Weight Loss and Lower Abdominal Pain SO MILITARY MEDICINE LA English DT Editorial Material C1 [Moser, Richard P., III] Walter Reed Army Med Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA. [Moser, Richard P., III; Pace, Maria Elena] Uniformed Serv Univ Hlth Sci, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. [Pace, Maria Elena] Natl Naval Med Ctr, 8901 Rockville Pike, Bethesda, MD 20889 USA. RP Moser, RP (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA.; Moser, RP (reprint author), Uniformed Serv Univ Hlth Sci, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD AUG PY 2016 VL 181 IS 8 BP 724 EP 725 DI 10.7205/MILMED-D-16-00070 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA DW5MI UT WOS:000383688900010 PM 27483503 ER PT J AU Pal, S Jasper, LE Lawrence, KL Walter, M Gilliland, T Dauner, AL Palys, TJ Wu, SJL AF Pal, Subhamoy Jasper, Louis E. Lawrence, Kendra L. Walter, Maureen Gilliland, Theron, Jr. Dauner, Allison L. Palys, Thomas J. Wu, Shuenn-Jue L. TI Assessing the Dengue Diagnosis Capability Gap in the Military Health System SO MILITARY MEDICINE LA English DT Article ID US MILITARY; FEVER AB Dengue, one of the most widespread infectious diseases, has affected U.S. military readiness throughout history. We explored the dengue diagnosis capability gap by circulating a questionnaire among military end users to determine in what capacity diagnostic test results are needed and how these results would be used at various roles of care in the Military Health System. Results were used to generate target product profiles for potential diagnostic tests. We determined that at far-forward locations, diagnostic tests need to be rugged and easy to use and are primarily needed to inform medical evacuation decisions. In mobile or fixed hospitals, diagnostics can be less portable but must be accurate enough to inform patient care decisions reliably. We then evaluated the suitability of using rapid diagnostic tests and enzyme-linked immunosorbent assays based on published performance characteristics, and we used a model to determine positive and negative predictive values in certain simulated deployments. In far-forward settings, a rapid diagnostic test comprising both antigen- and antibody-based detection can fulfill the capability gap with reasonable accuracy, whereas at higher roles of care immunoglobulin M-enzyme-linked immunosorbent assay was determined to be the most suitable option. C1 [Pal, Subhamoy; Gilliland, Theron, Jr.; Dauner, Allison L.; Wu, Shuenn-Jue L.] Naval Med Res Ctr, Viral & Rickettsial Dis Dept, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. [Jasper, Louis E.; Lawrence, Kendra L.; Walter, Maureen] US Army Med Mat Dev Act, 1430 Vet Dr, Ft Detrick, MD 21702 USA. [Palys, Thomas J.] Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. RP Pal, S (reprint author), Naval Med Res Ctr, Viral & Rickettsial Dis Dept, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. FU Military Infectious Diseases Research Program, U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland [6000.RAD1.L.A1221] FX We thank all participants who responded to the questionnaire, and the Dengue Rapid Diagnostics Device Integrated Product Team, U.S. Army Medical Research and Materiel Command, for making this work possible. This work was funded in part by the Military Infectious Diseases Research Program work unit number 6000.RAD1.L.A1221, U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland. NR 16 TC 0 Z9 0 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD AUG PY 2016 VL 181 IS 8 BP 756 EP 766 DI 10.7205/MILMED-D-15-00231 PG 11 WC Medicine, General & Internal SC General & Internal Medicine GA DW5MI UT WOS:000383688900018 PM 27483511 ER PT J AU Shanks, GD Burroughs, S Sohn, JD Waters, NC Smith, VF Waller, M Brundage, JF AF Shanks, G. Dennis Burroughs, Steven Sohn, Joshua D. Waters, Norman C. Smith, Virginia F. Waller, Michael Brundage, John F. TI Variable Mortality From the 1918-1919 Influenza Pandemic During Military Training SO MILITARY MEDICINE LA English DT Article ID ARMY AB During the 1918-1919 pandemic, influenza mortality widely varied across populations and locations. Records of U.S. military members in mobilization camps (n = 40), military academies, and officer training schools were examined to document differences in influenza experiences during the fall 1918. During the fall-winter 19181919, mortality percentages were higher among soldiers in U.S. Army mobilization camps (0.34-4.3%) than among officer trainees (0-1.0%). Susceptibility to infection and clinical expressions of 1918 pandemic influenza varied largely based on host epidemiological characteristics rather than the inherent virulence of the virus. C1 [Shanks, G. Dennis] Australian Army Malaria Inst, Gallipoli Barracks, Weary Dunlop Dr, Enoggera, Qld 4051, Australia. [Shanks, G. Dennis; Waller, Michael] Univ Queensland, Ctr Australian Mil & Vet Hlth, Sch Populat Hlth, 288 Herston Rd, Brisbane, Qld 2006, Australia. [Burroughs, Steven; Waters, Norman C.] US Mil Acad, Dept Chem, 646 Swift Rd, West Point, NY 10996 USA. [Sohn, Joshua D.; Smith, Virginia F.] US Naval Acad, Dept Chem, 572M Holloway Rd,MS-9B, Annapolis, MD 21402 USA. [Brundage, John F.] AFHSC, 11800 Tech Rd,Suite 220, Silver Spring, MD 20904 USA. RP Shanks, GD (reprint author), Australian Army Malaria Inst, Gallipoli Barracks, Weary Dunlop Dr, Enoggera, Qld 4051, Australia.; Shanks, GD (reprint author), Univ Queensland, Ctr Australian Mil & Vet Hlth, Sch Populat Hlth, 288 Herston Rd, Brisbane, Qld 2006, Australia. RI Waller, Michael/R-6231-2016 OI Waller, Michael/0000-0002-1050-4574 FU Global Emerging Infections Surveillance and Response System (GEIS) at the Armed Forces Health Surveillance Center of the U.S. Department of Defense FX We thank midshipmen (now Ensigns) Mary M. Coughlin and Corinne A. Landis for collecting data at the U.S. Naval Academy as well as Mrs. Alicia Mauldin at the U.S. Military Academy, Dr. Jennifer Bryan at the U.S. Naval Academy and Ms. Odette Hopwood at the Australian Defence Force Library, Gallipoli Barracks for help in locating data. The Global Emerging Infections Surveillance and Response System (GEIS) at the Armed Forces Health Surveillance Center of the U.S. Department of Defense provided funding for this project. NR 23 TC 0 Z9 0 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD AUG PY 2016 VL 181 IS 8 BP 878 EP 882 DI 10.7205/MILMED-D-15-00124 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA DW5MI UT WOS:000383688900034 PM 27483527 ER PT J AU Lawson, BD Kass, SJ Dhillon, MKK Milam, LS Cho, TH Rupert, AH AF Lawson, Ben D. Kass, Steven J. Dhillon, Maj Kieran K. Milam, Lana S. Cho, Timothy H. Rupert, Angus H. TI Military Occupations Most Affected by Head/Sensory Injuries and the Potential Job Impact of Those Injuries SO MILITARY MEDICINE LA English DT Article ID TRAUMATIC BRAIN-INJURY; EPIDEMIOLOGY; SOLDIERS; RETURN AB Objective: Identifying Department of Defense (DoD) occupations affected by injuries to the head and sensory systems. Methods: We explored the Defense Medical Epidemiology Database to identify occupations with the highest incidence of injured personnel, then ranked how frequently they occurred in a top 10 list for each of four injury categories (head/brain, visual, auditory, vestibular) encompassing 25 injury codes. Across all four categories, the most affected occupations were identified, among which we chose three Army combat-related military occupational specialties (MOSs) for detailed study. We identified skills needed to perform these MOSs and explored whether MOS-critical deficits could be expected following the injuries. Results: Some DoD occupations are more likely to suffer from these injuries, including Infantry, Combat Operations Control, Artillery/Gunnery, Motor Vehicle Operator, Combat Engineering, and Armor/Amphibious. Within these DoD occupations, we explored three Army combatant MOSs: Infantry (11B), Cavalry Scout (19D), and Artillery (13B), confirming that these jobs are likely to be disrupted by injuries within the four categories. Conclusions: Head and sensory injuries disproportionately affect certain military occupations. Relatively few injuries disrupt combat-related abilities that are job critical (e.g., firearms operation) and job specific (e.g., Artillery gunnery problems); these should be the focus of efforts to improve rehabilitation and RTD outcomes. C1 [Lawson, Ben D.; Milam, Lana S.; Cho, Timothy H.; Rupert, Angus H.] US Army, Aeromed Res Lab, Bldg 6901, Ft Rucker, AL 36362 USA. [Kass, Steven J.; Dhillon, Maj Kieran K.] Univ West Florida, Dept Psychol, Bldg 41, Pensacola, FL 32514 USA. RP Lawson, BD (reprint author), US Army, Aeromed Res Lab, Bldg 6901, Ft Rucker, AL 36362 USA. FU United States Army Medical Research and Materiel Command (USAMRMC), Fort Detrick, MD [12820] FX The funding sponsor was the United States Army Medical Research and Materiel Command (USAMRMC), Fort Detrick, MD, under Project 12820, Injury Prevention and Reduction Program Area (Return-to-Duty Task P). NR 24 TC 0 Z9 0 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD AUG PY 2016 VL 181 IS 8 BP 887 EP 894 DI 10.7205/MILMED-D-15-00184 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA DW5MI UT WOS:000383688900036 PM 27483529 ER PT J AU Lovalekar, MT Abt, JP Sell, TC Nagai, T Keenan, K Beals, K Lephart, SM Wirt, MD AF Lovalekar, Mita T. Abt, John P. Sell, Timothy C. Nagai, Takashi Keenan, Karen Beals, Kim Lephart, Scott M. Wirt, Michael D. TI Descriptive Epidemiology of Musculoskeletal Injuries in the Army 101st Airborne (Air Assault) Division SO MILITARY MEDICINE LA English DT Article ID PARACHUTE ANKLE BRACE; US ARMY; RISK-FACTORS; INFANTRY SOLDIERS; YOUNG MEN; MILITARY; RECOMMENDATIONS; SURVEILLANCE; AFGHANISTAN; PREVENTION AB The purpose of this study was to describe the epidemiology of musculoskeletal injuries among Soldiers of the 101st Airborne (Air Assault) Division. A total of 451 subjects (age: 27.6 +/- 6.2 years, gender: males 395/451 = 87.6%) volunteered. Musculoskeletal injury data were extracted from subjects' medical charts and injuries that occurred during 1 year were described. Injury frequency, injury anatomic location and sublocation, injury cause, activity when injury occurred, and injury type were described. Injury frequency was 29.5 injuries per 100 subjects per year. Most injures affected the lower extremity (60.2% of injuries) and common anatomic sublocations for injuries were the ankle (17.3%) and knee (15.0%). Frequent causes of injuries were running (13.5%) and direct trauma (9.0%). Physical training was associated with 29.3% of the injuries. A majority of injuries were classified as pain/spasm/ache (29.3%), without further elucidation of pathology. Other frequent injury types were sprain (21.8%) and strain (14.3%). The descriptive epidemiology of musculoskeletal injuries in this population underscores the need to explore the modifiable risk factors of potentially preventable lower extremity injuries associated with physical training and running. There is scope for the development of an optimized and targeted physical training program for injury prevention in this population. C1 [Lovalekar, Mita T.; Sell, Timothy C.; Nagai, Takashi; Keenan, Karen; Beals, Kim] Univ Pittsburgh, Sch Hlth & Rehabil Sci, Dept Sports Med & Nutr, Neuromuscular Res Lab, 3230 South Water St, Pittsburgh, PA 15203 USA. [Abt, John P.; Lephart, Scott M.] Univ Kentucky, Charles T Wethington Jr Bldg, Lexington, KY 40536 USA. [Wirt, Michael D.] US Army, Inst Surg Res, 3698 Chambers Pass,Bldg 3611, Jbsa Ft Sam Houston, TX 78234 USA. RP Lovalekar, MT (reprint author), Univ Pittsburgh, Sch Hlth & Rehabil Sci, Dept Sports Med & Nutr, Neuromuscular Res Lab, 3230 South Water St, Pittsburgh, PA 15203 USA. FU U.S. Army Medical Research and Materiel Command [W81XWH-06-2-0070/W81XWH-09-2-0095/W81XWH-11-2-0097] FX We would like to thank those Soldiers who participated in this study. This work was supported by the U.S. Army Medical Research and Materiel Command under award number W81XWH-06-2-0070/W81XWH-09-2-0095/W81XWH-11-2-0097. NR 43 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD AUG PY 2016 VL 181 IS 8 BP 900 EP 906 DI 10.7205/MILMED-D-15-00262 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA DW5MI UT WOS:000383688900038 PM 27483531 ER PT J AU Alvarado, GR Basel, AP Hatzigeorgiou, C Fincher, RK AF Alvarado, Gadiel R. Basel, Anthony P. Hatzigeorgiou, Christos Fincher, R. Keith TI Effect of a Polyp Tracking and Notification Program on Colon Adenoma Surveillance and Compliance to Guideline Recommendations SO MILITARY MEDICINE LA English DT Article ID SOCIETY-TASK-FORCE; COLORECTAL-CANCER; COLONOSCOPY SURVEILLANCE; CONSENSUS UPDATE; POLYPECTOMY; CARE AB Background: Colorectal cancer is the third leading cause of cancer in the United States. Surveillance colonoscopy has been shown to reduce colorectal cancer risk. Medical institutions have implemented polyp tracking and notification programs (registries) to ensure adequate surveillance. Aim: To assess the effectiveness of a registry notification program initiated in January 2006 on the surveillance colonoscopy completion rate and adherence to surveillance guidelines. Methods: Retrospective record review of beneficiaries with an adenomatous polyp between 2004 and 2007, with expected repeat surveillance colonoscopy between 2007 and 2012. Records were divided in 2 groups: Pre-Registry (4/04-12/05) and Registry (1/06-6/07). Successful surveillance was defined as beneficiaries who completed or were offered a colonoscopy within 12 months after the recommended interval. Results: A total of 853 beneficiary records were reviewed, with 88 records excluded. Pre-Registry mean age was 60.1 years and % male gender was 63.5%, compared to Registry mean age of 60.9 years and % male gender of 58.4%. Significantly more beneficiaries completed or were offered colonoscopy surveillance in the Registry group, compared to the Pre-Registry group, (85.1% vs. 43.7%, p < 0.001). Conclusion: The use of a polyp tracking registry and notification program improves adherence to current polyp surveillance guidelines. C1 [Alvarado, Gadiel R.; Basel, Anthony P.] Eisenhower Army Med Ctr, Dept Med, 300 East Hosp Dr, Ft Gordon, GA 30905 USA. [Hatzigeorgiou, Christos] Augusta Univ, 1120 15th St,BI5070, Augusta, GA 30912 USA. [Hatzigeorgiou, Christos] Eisenhower Army Med Ctr, Internal Med Clin, 300 East Hosp Dr, Ft Gordon, GA 30905 USA. [Fincher, R. Keith] Eisenhower Army Med Ctr, Dept Gastroenterol, Transit Year Program, 300 East Hosp Dr, Ft Gordon, GA 30905 USA. RP Alvarado, GR (reprint author), Eisenhower Army Med Ctr, Dept Med, 300 East Hosp Dr, Ft Gordon, GA 30905 USA. NR 19 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD AUG PY 2016 VL 181 IS 8 BP 920 EP 925 DI 10.7205/MILMED-D-15-00320 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA DW5MI UT WOS:000383688900041 PM 27483534 ER PT J AU Madigan, CG Wang, JY AF Madigan, Cory G. Wang, James Y. TI Cirrhosis in an Active Duty Soldier With Concomitant Isolated Polycystic Disease and H63D Homozygosity SO MILITARY MEDICINE LA English DT Article ID LIVER-DISEASE; HEMOCHROMATOSIS AB We report the case of a 45-year-old male soldier who was evaluated for a rapidly expanding hepatic mass following cholecystectomy and was eventually found to have isolated polycystic liver disease and express HFE H63D homozygosity. Both H63D homozygosity and isolated polycystic liver disease are only rarely associated with clinical cirrhosis. This is the first reported case of their concomitant presentation. C1 [Madigan, Cory G.] Tripler Army Med Ctr, Dept Med, 1 Jarrett White Rd, Honolulu, HI 96859 USA. [Wang, James Y.] Tripler Army Med Ctr, Dept Med, Div Gastroenterol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. RP Madigan, CG (reprint author), Tripler Army Med Ctr, Dept Med, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD AUG PY 2016 VL 181 IS 8 BP E965 EP E967 DI 10.7205/MILMED-D-15-00455 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA DW5MI UT WOS:000383688900007 PM 27483545 ER PT J AU Reha, J Davis, P AF Reha, Jeffrey Davis, Patrick TI Occult Pneumomediastinum in the Deployed Setting: Evaluation and Management SO MILITARY MEDICINE LA English DT Article ID BLUNT CHEST TRAUMA; CT AB Pneumomediastinum can occur after both blunt and penetrating trauma. The greatest concern involving this finding in a trauma patient is an aerodigestive tract injury. Prompt evaluation, identification, and management of these injuries are extremely important. This case describes a soldier who was involved in an improvised explosive device blast with no evidence of cavity penetration. During the routine evaluation of his head and neck an occult pneumomediastinum was identified. The patient was asymptomatic and was further evaluated with computed tomography because of the absence of endoscopy and bronchoscopy in theatre. The imaging showed no evidence of esophageal or tracheobronchial injury. The patient was observed and when noted to be stable was transferred to the local Role 3 hospital for management of his other injuries. C1 [Reha, Jeffrey] Blanchfield Army Community Hosp, 650 Joel Dr, Ft Campbell, KY 42223 USA. [Davis, Patrick] Reynolds Army Community Hosp, 4301 Wilson St, Ft Sill, OK 73503 USA. RP Reha, J (reprint author), Blanchfield Army Community Hosp, 650 Joel Dr, Ft Campbell, KY 42223 USA. NR 12 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD AUG PY 2016 VL 181 IS 8 BP E959 EP E961 DI 10.7205/MILMED-D-15-00334 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA DW5MI UT WOS:000383688900005 PM 27483543 ER PT J AU Vahedifard, F Howard, IL Badran, WH Carruth, WD Hamlehdari, M Jordan, BD AF Vahedifard, Farshid Howard, Isaac L. Badran, Walaa H. Carruth, William D. Hamlehdari, Maysam Jordan, Brian D. TI Strength indices of high-moisture soils using handheld gauges SO PROCEEDINGS OF THE INSTITUTION OF CIVIL ENGINEERS-GROUND IMPROVEMENT LA English DT Article DE dredging; geotechnical engineering; strength and testing of materials ID SHEAR-STRENGTH; PENETROMETER; SLUDGE; FIELD AB Large volumes of very high moisture content fine-grained soils (very high-moisture soils (VHMS)) are encountered annually. Stabilisation of these soils has been documented as a promising approach for disposal or reuse. Construction using stabilised fine-grained soils with high moisture contents is highly dependent on strength gain with time. This study evaluated the ability of handheld gauges to provide a rapid strength index in VHMS. The results obtained from pocket penetrometer, pocket geotester and pocket vane shear set were evaluated. Testing matrices included using three fine-grained soils and five types of Portland cement. Handheld gauges were used to measure a strength index for numerous cases, resulting in more than 2000 readings with each of the gauges. Approximately 300 unconfined compression tests were also conducted and the results were used to develop strength correlations to handheld gauge indices. The results showed that, in general, there was no considerable proximity difference between the pocket geotester and the pocket penetrometer, but there was a considerable difference relative to the pocket vane shear set. A comparison between the coefficients of variation showed the pocket geotester to be the most repeatable. It is noted that these devices only provide index values and additional tests are always recommended on field samples. C1 [Vahedifard, Farshid; Howard, Isaac L.; Badran, Walaa H.; Hamlehdari, Maysam; Jordan, Brian D.] Mississippi State Univ, Dept Civil & Environm Engn, Starkville, MS 39759 USA. [Carruth, William D.] US Army Engineer Res & Dev Ctr, Vicksburg, MS USA. RP Vahedifard, F (reprint author), Mississippi State Univ, Dept Civil & Environm Engn, Starkville, MS 39759 USA. NR 47 TC 1 Z9 1 U1 0 U2 0 PU ICE PUBLISHING PI WESTMINISTER PA INST CIVIL ENGINEERS, 1 GREAT GEORGE ST, WESTMINISTER SW 1P 3AA, ENGLAND SN 1755-0750 EI 1755-0769 J9 PROC INST CIV ENG-GR JI Proc. Inst. Civ. Eng.-Ground Improv. PD AUG PY 2016 VL 169 IS 3 BP 167 EP 181 AR 1400033 DI 10.1680/jgrim.14.00033 PG 15 WC Engineering, Geological SC Engineering GA EC8LJ UT WOS:000388392700003 ER PT J AU van Ramshorst, MCJ Di Benedetto, GL Duvalois, W Hooijmeijer, PA van der Heijden, AEDM AF van Ramshorst, Marthinus C. J. Di Benedetto, Giuseppe L. Duvalois, Willem Hooijmeijer, Peter A. van der Heijden, Antoine E. D. M. TI Investigation of the Failure Mechanism of HTPB/AP/Al Propellant by In-situ Uniaxial Tensile Experimentation in SEM SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE Propellant; Micromechanical deformation; In-situ tensile testing; In-situ SEM; Mechanical properties ID MICROMECHANICAL DEFORMATION PROCESSES; FILLED SEMICRYSTALLINE POLYMERS; ROCKET PROPELLANTS; DEPENDENCE AB The failure mechanism of a propellant consisting of hydroxyl terminated poly-butadiene filled with ammonium perchlorate and aluminum (HTPB/AP/Al) was determined by performing in-situ uniaxial tensile tests in a scanning electron microscope (SEM). The experimental test plan contained uniaxial tensile test experiments performed at room temperature (25 degrees C) at three different strain rates (30, 150 and 750mmin(-1)). The in-situ images and in-situ videos collected by the SEM were correlated with the stress-strain diagrams created with the tensile experiments, in order to relate the failure mechanism to the features found in the stress-strain diagram. No significant strain rate dependency of the failure mechanism was observed when working with strain rates up to 750mmin(-1) and working at room temperature. The stress-strain diagram showed indications of existing cracks and voids opening up prior to the creation of new cracks and/or voids in the sample, debonding of binder with AP particles as well as nucleation and coalescence of voids. On the fracture surfaces of the samples, it was apparent that the binder cleanly separated from the large AP particles but had a better bond with the aluminum particles. However, a difference in the appearance of a short drawing phase in the stress-strain diagram of the propellant is observed at different strain rates. The presented results clearly demonstrate the major advantage of the combination of microscopic tensile tests with microscopic observations, linking the stress-strain behavior to the mechanical deformation processes taking place in these propellant samples at the microscopic level. C1 [van Ramshorst, Marthinus C. J.; Di Benedetto, Giuseppe L.; Duvalois, Willem; Hooijmeijer, Peter A.; van der Heijden, Antoine E. D. M.] TNO Def Secur & Safety, Dept Energet Mat, POB 45, NL-2280 AA Rijswijk, Netherlands. [van Ramshorst, Marthinus C. J.] Delft Univ Technol, Dept Mat Sci & Engn, Mekelweg 2, NL-2628 CD Delft, Netherlands. [Di Benedetto, Giuseppe L.] US Army RDECOM ARDEC, Adv Mat Technol Branch, Picatinny Arsenal, NJ 07806 USA. [van der Heijden, Antoine E. D. M.] Delft Univ Technol, Sect Intensified React & Separat Syst, Leeghwaterstr 39, NL-2526 CB Delft, Netherlands. RP van der Heijden, AEDM (reprint author), TNO Def Secur & Safety, Dept Energet Mat, POB 45, NL-2280 AA Rijswijk, Netherlands.; van der Heijden, AEDM (reprint author), Delft Univ Technol, Sect Intensified React & Separat Syst, Leeghwaterstr 39, NL-2526 CB Delft, Netherlands. EM antoine.vanderheijden@tno.nl NR 16 TC 0 Z9 0 U1 4 U2 4 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 0721-3115 EI 1521-4087 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD AUG PY 2016 VL 41 IS 4 BP 700 EP 708 DI 10.1002/prep.201500264 PG 9 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA DW3XO UT WOS:000383576600015 ER PT J AU Snow, AD Christensen, SD Swain, NR Nelson, EJ Ames, DP Jones, NL Ding, D Noman, NS David, CH Pappenberger, F Zsoter, E AF Snow, Alan D. Christensen, Scott D. Swain, Nathan R. Nelson, E. James Ames, Daniel P. Jones, Norman L. Ding, Deng Noman, Nawajish S. David, Cedric H. Pappenberger, Florian Zsoter, Ervin TI A HIGH-RESOLUTION NATIONAL-SCALE HYDROLOGIC FORECAST SYSTEM FROM A GLOBAL ENSEMBLE LAND SURFACE MODEL SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article DE ECMWF; RAPID; Tethys Platform; CondorPy; HTCondor; CI-WATER; GloFAS; NFIE; flood prediction; streamflow prediction; forecast ID PREDICTION; UNCERTAINTY; IGNORANCE; ECMWF AB Warning systems with the ability to predict floods several days in advance have the potential to benefit tens of millions of people. Accordingly, large-scale streamflow prediction systems such as the Advanced Hydrologic Prediction Service or the Global Flood Awareness System are limited to coarse resolutions. This article presents a method for routing global runoff ensemble forecasts and global historical runoff generated by the European Centre for Medium-Range Weather Forecasts model using the Routing Application for Parallel computation of Discharge to produce high spatial resolution 15-day stream forecasts, approximate recurrence intervals, and warning points at locations where streamflow is predicted to exceed the recurrence interval thresholds. The processing method involves distributing the computations using computer clusters to facilitate processing of large watersheds with high-density stream networks. In addition, the Streamflow Prediction Tool web application was developed for visualizing analyzed results at both the regional level and at the reach level of high-density stream networks. The application formed part of the base hydrologic forecasting service available to the National Flood Interoperability Experiment and can potentially transform the nation's forecast ability by incorporating ensemble predictions at the nearly 2.7 million reaches of the National Hydrography Plus Version 2 Dataset into the national forecasting system. C1 [Snow, Alan D.] US Army Engineer Res & Dev Ctr, Coastal & Hydraul Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. [Christensen, Scott D.; Swain, Nathan R.; Nelson, E. James; Ames, Daniel P.; Jones, Norman L.] Brigham Young Univ, Dept Civil & Environm Engn, Provo, UT 84602 USA. [Ding, Deng; Noman, Nawajish S.] Esri, Redlands, CA 92373 USA. [David, Cedric H.] CALTECH, Jet Prop Lab, 4800 Oak Grove Dr, Pasadena, CA 91109 USA. [Pappenberger, Florian; Zsoter, Ervin] European Ctr Medium Range Weather Forecasts, Shinfield Pk, Reading, Berks, England. RP Snow, AD (reprint author), US Army Engineer Res & Dev Ctr, Coastal & Hydraul Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM alan.d.snow@usace.army.mil RI Pappenberger, Florian/A-2839-2009; OI Pappenberger, Florian/0000-0003-1766-2898; Snow, Alan/0000-0002-7333-3100 FU National Science Foundation [1135483]; Jet Propulsion Laboratory; California Institute of Technology; National Aeronautics and Space Administration FX This research is based upon work supported by the National Science Foundation under Grant No. 1135483. Cedric H. David was supported by the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration. We would also like to express appreciation to Curtis Rae for his assistance in the GIS preprocessing of the NFIE regions. NR 29 TC 2 Z9 2 U1 4 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1093-474X EI 1752-1688 J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD AUG PY 2016 VL 52 IS 4 BP 950 EP 964 DI 10.1111/1752-1688.12434 PG 15 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA EB2DW UT WOS:000387168800013 ER PT J AU Pellerin, BA Stauffer, BA Young, DA Sullivan, DJ Bricker, SB Walbridge, MR Clyde, GA Shaw, DM AF Pellerin, Brian A. Stauffer, Beth A. Young, Dwane A. Sullivan, Daniel J. Bricker, Suzanne B. Walbridge, Mark R. Clyde, Gerard A., Jr. Shaw, Denice M. TI EMERGING TOOLS FOR CONTINUOUS NUTRIENT MONITORING NETWORKS: SENSORS ADVANCING SCIENCE AND WATER RESOURCES PROTECTION SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article DE sensors; nutrients; water quality; information management ID HARMFUL ALGAL BLOOMS; SPRING-FED RIVER; IN-SITU SENSORS; MISSISSIPPI RIVER; HIGH-RESOLUTION; DRINKING-WATER; WASTE-WATER; DATA DELUGE; NITRATE; FREQUENCY AB Sensors and enabling technologies are becoming increasingly important tools for water quality monitoring and associated water resource management decisions. In particular, nutrient sensors are of interest because of the well-known adverse effects of nutrient enrichment on coastal hypoxia, harmful algal blooms, and impacts to human health. Accurate and timely information on nutrient concentrations and loads is integral to strategies designed to minimize risk to humans and manage the underlying drivers of water quality impairment. Using nitrate sensors as the primary example, we highlight the types of applications in freshwater and coastal environments that are likely to benefit from continuous, real-time nutrient data. The concurrent emergence of new tools to integrate, manage, and share large datasets is critical to the successful use of nutrient sensors and has made it possible for the field of continuous monitoring to rapidly move forward. We highlight several near-term opportunities for federal agencies, as well as the broader scientific and management community, that will help accelerate sensor development, build and leverage sites within a national network, and develop open data standards and data management protocols that are key to realizing the benefits of a large-scale, integrated monitoring network. Investing in these opportunities will provide new information to guide management and policies designed to protect and restore our nation's water resources. C1 [Pellerin, Brian A.] US Geol Survey, Calif Water Sci Ctr, 6000 J St,Placer Hall, Sacramento, CA 95819 USA. [Stauffer, Beth A.] Univ Louisiana Lafayette, Dept Biol, Lafayette, LA 70504 USA. [Young, Dwane A.] US EPA, Off Water, Washington, DC 20460 USA. [Sullivan, Daniel J.] US Geol Survey, Wisconsin Water Sci Ctr, Middleton, WI 53562 USA. [Bricker, Suzanne B.] NOAA, Natl Ctr Coastal Ocean Sci, Silver Spring, MD 20910 USA. [Walbridge, Mark R.] ARS, USDA, Beltsville, MD 20705 USA. [Clyde, Gerard A., Jr.] US Army Corp Engineers, Tulsa Dist, Tulsa, OK 74128 USA. [Shaw, Denice M.] US EPA, Off Res & Dev, Washington, DC 20460 USA. RP Pellerin, BA (reprint author), US Geol Survey, Calif Water Sci Ctr, 6000 J St,Placer Hall, Sacramento, CA 95819 USA. EM bpeller@usgs.gov FU USGS Office of Water Quality; USGS National Water Quality Assessment Program; National Water Quality Monitoring Council FX The authors benefited from insights and comments from Robert Gilliom, Charles Crawford, Donna Myers, Bill Wilber, Gary Rowe, Pixie Hamilton, Mark Nilles, Andy Ziegler, Jeff Lape, and Richard Mitchell. We thank Pete Penoyer (National Park Service) and two anonymous reviewers for helpful comments on the manuscript. This article was supported by the USGS Office of Water Quality, the USGS National Water Quality Assessment Program, and the National Water Quality Monitoring Council. NR 81 TC 1 Z9 1 U1 11 U2 11 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1093-474X EI 1752-1688 J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD AUG PY 2016 VL 52 IS 4 BP 993 EP 1008 DI 10.1111/1752-1688.12386 PG 16 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA EB2DW UT WOS:000387168800016 ER PT J AU Harshman, SG Fu, XY Karl, JP Barger, K Lamon-Fava, S Kuliopulos, A Greenberg, AS Smith, D Shen, XH Booth, SL AF Harshman, Stephanie G. Fu, Xueyan Karl, J. Philip Barger, Kathryn Lamon-Fava, Stefania Kuliopulos, Athan Greenberg, Andrew S. Smith, Donald Shen, Xiaohua Booth, Sarah L. TI Tissue Concentrations of Vitamin K and Expression of Key Enzymes of Vitamin K Metabolism Are Influenced by Sex and Diet but Not Housing in C57Bl6 Mice SO JOURNAL OF NUTRITION LA English DT Article DE coprophagy; Ggcx; long-chain menaquinones; menaquinone-4; phylloquinone; suspended wire cages; Ubiad1; vitamin K; Vkorc1; Vkorc1l1 ID GAMMA-GLUTAMYL CARBOXYLASE; MENAQUINONE-4 VITAMIN-K-2; PHYLLOQUINONE VITAMIN-K-1; GLUCOSE-METABOLISM; RATS; DEFICIENT; CONVERSION; BACTERIA; AGE; REQUIREMENTS AB Background: There has been limited characterization of biological variables that impact vitamin K metabolism. This gap in knowledge can limit the translation of data obtained from preclinical animal studies to future human studies. Objective: The purpose of this study was to determine the effects of diet, sex, and housing on serum, tissue, and fecal vitamin K concentrations and gene expression in C57BL6 mice during dietary vitamin K manipulation. Methods: C57BL6 4-mo-old male and female mice were randomly assigned to conventional or suspended-wire cages and fed control [1400 +/- 80 mu g phylloquinone (PK)/kg] or deficient (31 +/- 0.45 mu g PK/kg) diets for 28 d in a factorial design. PK and menaquinone (MK) 4 plasma and tissue concentrations were measured by HPLC. Long-chain MKs were measured in all matrices by LC-atmospheric pressure chemical ionization-mass spectrometry. Gene expression was quantified by reverse transcriptase-polymerase chain reaction in the liver, brain, kidney, pancreas, and adipose tissue. Results: Male and female mice responded differently to dietary manipulation in a tissue-dependent manner. In mice fed the control diet, females had similar to 3-fold more MK4 in the brain and mesenteric adipose tissue than did males and 100% greater PK concentrations in the liver, kidney, and mesenteric adipose tissue than did males. In mice fed the deficient diet, kidney MK4 concentrations were similar to 4-fold greater in females than in males, and there were no differences in other tissues. Males and females differed in the expression of vitamin K expoxide reductase complex 1 (Vkorc1) in mesenteric adipose tissue and the pancreas and ubiA domain-containing protein 1 (Ubiad1) in the kidney and brain. There was no effect of housing on serum, tissue, or fecal concentrations of any vitamin K form. Conclusions: Vitamin K concentrations and expression of key metabolic enzymes differ between male and female mice and in response to the dietary PK concentration. Identifying factors that may impact study design and outcomes of interest is critical to optimize study parameters examining vitamin K metabolism in animal models. C1 [Harshman, Stephanie G.; Fu, Xueyan; Barger, Kathryn; Lamon-Fava, Stefania; Greenberg, Andrew S.; Smith, Donald; Shen, Xiaohua; Booth, Sarah L.] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA. [Karl, J. Philip] US Army Res Inst Environm Med, Natick, MA USA. [Kuliopulos, Athan] Tufts Univ, Sackler Sch Biomed Sci, Boston, MA 02111 USA. RP Booth, SL (reprint author), Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA. EM sarah.booth@tufts.edu FU USDA Agricultural Research Service [58-1950-7-707]; NIH/NIDDK [T32 DK062032] FX Supported by the USDA Agricultural Research Service under Cooperative Agreement 58-1950-7-707 and NIH/NIDDK grant T32 DK062032 (to SGH). NR 51 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-3166 EI 1541-6100 J9 J NUTR JI J. Nutr. PD AUG PY 2016 VL 146 IS 8 BP 1521 EP 1527 DI 10.3945/jn.116.233130 PG 7 WC Nutrition & Dietetics SC Nutrition & Dietetics GA DZ8OT UT WOS:000386130900008 PM 27385762 ER PT J AU Lushniak, B Mallon, TM Gaydos, JC Smith, DJ AF Lushniak, Boris Mallon, Timothy M. Gaydos, Joel C. Smith, David J. TI Utility of the Department of Defense Serum Repository in Assessing Deployment Exposure SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Editorial Material ID ENVIRONMENTAL EXPOSURES; HEALTH; 21ST-CENTURY AB Objective: This paper describes why the research project was conducted in terms of demonstrating the utility of the Department of Defense Serum Repository in addressing deployment environmental exposures. Methods: The history deployment exposure surveillance was reviewed and the rationale for developing validated biomarkers that were detected in sera in postdeployment samples and compared with nondeployed controls was described. The goal was to find validated biomarkers that are associated with both exposures and health outcomes. Results: The articles in this supplement described novel serum biomarkers that were found to be associated with deployment exposures and weakly associated with some health outcomes. Conclusions: Future research must continue to validate the use of serum biomarkers when operational contingencies prevent the gold standard collection of real-time breathing zone samples in deployed service members. C1 [Lushniak, Boris; Mallon, Timothy M.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biostat, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. [Gaydos, Joel C.] US Army, Publ Hlth Ctr Provis, Aberdeen Proving Ground, MD USA. RP Mallon, TM (reprint author), Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biostat, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.; Mallon, TM (reprint author), Uniformed Serv Univ Hlth Sci, Natl Capital Consortium, Occupat & Environm Med Residency Program, Sch Med,Dept Prevent Med & Biostat, Bldg A Room A1040A,4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM timothy.mallon@usuhs.edu NR 21 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1076-2752 EI 1536-5948 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD AUG PY 2016 VL 58 IS 8 SU S BP S1 EP S2 DI 10.1097/JOM.0000000000000796 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA EA1IG UT WOS:000386345100001 PM 27501096 ER PT J AU Mallon, TM Rohrbeck, P Haines, KM Jones, DP Utell, M Hopke, PK Phipps, RP Walker, DI Thatcher, T Woeller, CF Baird, CP Pollard, HB Dalgard, CL Gaydos, JC AF Mallon, Timothy M. Rohrbeck, Patricia Haines, Kevin M. Jones, Dean P. Utell, Mark Hopke, Philip K. Phipps, Richard P. Walker, Douglas I. Thatcher, Thomas Woeller, Collynn F. Baird, Coleen P. Pollard, Harvey B. Dalgard, Clifton L. Gaydos, Joel C. TI Introduction to Department of Defense Research on Burn Pits, Biomarkers, and Health Outcomes Related to Deployment in Iraq and Afghanistan SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Editorial Material ID DOD SERUM REPOSITORY; RETROSPECTIVE COHORT; RESPIRATORY HEALTH; EXPOSURE; SURVEILLANCE; ENCOUNTERS; FUTURE AB Objective: This paper provides an overview of our study that was designed to assess the health impact of environmental exposures to open pit burning in deployed troops. Methods: The rationale for the study and the structure of the research plan was laid out. An overview of each article in the supplement was provided. The cohort of deployed Service members was assessed for airborne exposure, relevant biomarkers, and health outcomes following deployment to Balad, Iraq, and/or Bagram, Afghanistan. Results: Polycyclic aromatic hydrocarbon (PAH) exposures were elevated, and serum biomarkers were statistically different postdeployment. Associations were noted between PAHs and dioxins and microRNAs. Some health outcomes were evident in deployers compared with nondeployers. Conclusions: Future research will examine the associations between demographic variables, smoking status, biomarker levels, and related health outcomes. C1 [Mallon, Timothy M.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biostat, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. [Rohrbeck, Patricia] 779th Aerosp Med Squadron, 79th Med Wing, Joint Base Andrews, MD USA. [Haines, Kevin M.] 30th Med Grp, 338 South Dakota Ave, Vandenberg AFB, CA 93437 USA. [Jones, Dean P.; Walker, Douglas I.] Div Pulm Allergy & Crit Care Med, Clin Biomarkers Lab, Atlanta, GA USA. [Utell, Mark; Phipps, Richard P.; Thatcher, Thomas; Woeller, Collynn F.] Univ Rochester, Med Ctr, Dept Med, Rochester, NY 14627 USA. [Utell, Mark; Phipps, Richard P.; Thatcher, Thomas; Woeller, Collynn F.] Univ Rochester, Med Ctr, Dept Environm Med, Rochester, NY 14627 USA. [Hopke, Philip K.] Clarkson Univ, Inst Sustainable Environm, Ctr Air Resources Engn & Sci, Potsdam, NY USA. [Baird, Coleen P.; Gaydos, Joel C.] US Army, Ctr Publ Hlth Provis, Aberdeen Proving Ground, MD USA. [Pollard, Harvey B.; Dalgard, Clifton L.] Uniformed Serv Univ Hlth Sci, Anat & Cell Biol, Bethesda, MD USA. RP Mallon, TM (reprint author), Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biostat, Occupat & Environm Med Residency Program, Natl Capital Consortium,Sch Med, Bldg A Room A1040A,4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM mallon@usuhs.edu NR 36 TC 3 Z9 3 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1076-2752 EI 1536-5948 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD AUG PY 2016 VL 58 IS 8 SU S BP S3 EP S11 DI 10.1097/JOM.0000000000000775 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA EA1IG UT WOS:000386345100002 ER PT J AU Xie, KY Kuwelkar, K Haber, RA LaSalvia, JC Hemker, KJ AF Xie, Kelvin Y. Kuwelkar, Kanak Haber, Richard A. LaSalvia, Jerry C. Hemker, Kevin J. TI Microstructural Characterization of a Commercial Hot-Pressed Boron Carbide Armor Plate SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Article DE boron carbide; transmission electron microscopy ID MECHANICAL-PROPERTIES; SILICON-NITRIDE; CARBON SYSTEM; COMPOSITES; PHASE; B4C; CERAMICS; DENSIFICATION; ADDITIONS; ALUMINUM AB Detailed microstructural characterization was carried out on a commercial-grade hot-pressed boron carbide armor plate. The boron carbide grains have close to B4C stoichiometry, and most of them have no planar defects. The most prominent second phase is intergranular graphite inclusions that are surrounded by multiple boron carbide grains. Submicrometer intragranular and intergranular BN and AlN precipitates were also observed. In addition, fine dispersions of AlN nanoprecipitates were observed in some but not all grains. No intergranular films were found. These microstructural characteristics are compared with the lab-consolidated boron carbide and their effects on the mechanical properties of boron carbide are addressed. C1 [Xie, Kelvin Y.; Hemker, Kevin J.] Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. [Kuwelkar, Kanak; Haber, Richard A.] Rutgers State Univ, Ceram & Composite Mat Ctr, New Brunswick, NJ 08854 USA. [LaSalvia, Jerry C.] US Army Res Lab, Aberdeen, MD 21005 USA. RP Hemker, KJ (reprint author), Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. EM hemker@jhu.edu FU Army Research Laboratory [W911NF-12-2-0022] FX Research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-12-2-0022. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 47 TC 2 Z9 2 U1 6 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-7820 EI 1551-2916 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD AUG PY 2016 VL 99 IS 8 BP 2834 EP 2841 DI 10.1111/jace.14295 PG 8 WC Materials Science, Ceramics SC Materials Science GA EA4HW UT WOS:000386573200039 ER PT J AU Powell-Dunford, N Quesada, JF Gross, KR Shackelford, SA AF Powell-Dunford, Nicole Quesada, Jose F. Gross, Kirby R. Shackelford, Stacy A. TI Army Air Ambulance Blood Product Program in the Combat Zone and Challenges to Best Practices SO AEROSPACE MEDICINE AND HUMAN PERFORMANCE LA English DT Article DE blood; transfusion; medevac; pre-hospital; resuscitation ID OPERATIONS; CARE AB BACKGROUND: Identify challenges and best practices in the development of an austere air ambulance transfusion program. METHODS: A search of PubMed using combinations of the key terms 'prehospital,' 'blood product,' 'red blood cells,' 'damage control resuscitation,' 'transfusion,' 'air ambulance,' 'medical evacuation,' and 'medevac' yielded 196 articles for further analysis, with 14 articles suitable for addressing the background of prehospital transfusion within a helicopter. Retrospective analysis of unclassified briefs, after action reports, and procedures was also undertaken along with interview of subject matter experts. The initial series of 15 transfusions were discussed telephonically among flight crew, trauma surgeons, and lab specialists. Review of Joint Theater System data was readily available for 84 U.S. Army air ambulance transfusions between May-December 2012, with December marking the redeployment of the 25th Combat Aviation Brigade. RESULTS: Standardized implementation enabled safe blood product administration for 84 causalities from May-December 2012 without blood product shortage, expiration, or transfusion reaction. Challenges included developing transfusion competency, achieving high quality blood support, countering the potential for anti-U.S. sentiment, and diversity in coalition transfusion practices. DISCUSSION: Blood product administration aboard the air ambulance is logistically complex, requiring blood bank integration. Repetitive training enabled emergency medical technicians (EMTs) with basic medical training to safely perform transfusion in accordance with clinical operating guidelines. In the austere environment, logistic factors are significant challenges and political sensitivities are important considerations. Best practices may facilitate new en route transfusion programs. C1 [Powell-Dunford, Nicole] US Army Aeromed Res Lab, Ft Rucker, AL USA. US Army Inst Surg Res, Brooke Army Med Ctr, Dept Emergency Med, San Antonio Mil Med Ctr, San Antonio, TX USA. [Shackelford, Stacy A.] US Army Inst Surg Res, Joint Trauma Syst, Ft Sam Houston, TX USA. [Quesada, Jose F.; Gross, Kirby R.] US Army Inst Surg Res, San Antonio Mil Med Ctr, Dept Emergency Med, San Antonio, TX USA. RP Powell-Dunford, N (reprint author), USAARL, PSC 50,Box 827, APO, AE 09494 USA. EM nicole.c.powell-dunford.mil@mail.mil NR 12 TC 0 Z9 0 U1 1 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 2375-6314 EI 2375-6322 J9 AEROSP MED HUM PERF JI Aerosp. Med.Hum. Perform. PD AUG PY 2016 VL 87 IS 8 BP 728 EP 734 DI 10.3357/AMHP.4492.2016 PG 7 WC Biophysics; Public, Environmental & Occupational Health; Medicine, Research & Experimental SC Biophysics; Public, Environmental & Occupational Health; Research & Experimental Medicine GA DY2KD UT WOS:000384920600007 PM 27634608 ER PT J AU Kilianski, A Roth, PA Liem, AT Hill, JM Willis, KL Rossmaier, RD Marinich, AV Maughan, MN Karavis, MA Kuhn, JH Honko, AN Rosenzweig, CN AF Kilianski, Andy Roth, Pierce A. Liem, Alvin T. Hill, Jessica M. Willis, Kristen L. Rossmaier, Rebecca D. Marinich, Andrew V. Maughan, Michele N. Karavis, Mark A. Kuhn, Jens H. Honko, Anna N. Rosenzweig, C. Nicole TI Use of Unamplified RNA/cDNA-Hybrid Nanopore Sequencing for Rapid Detection and Characterization of RNA Viruses SO EMERGING INFECTIOUS DISEASES LA English DT Article ID EBOLA-VIRUS; REAL-TIME; TRANSMISSION; OUTBREAK; IDENTIFICATION; SURVEILLANCE AB Nanopore sequencing, a novel genomics technology, has potential applications for routine biosurveillance, clinical diagnosis, and outbreak investigation of virus infections. Using rapid sequencing of unamplified RNA/cDNA hybrids, we identified Venezuelan equine encephalitis virus and Ebola virus in 3 hours from sample receipt to data acquisition, demonstrating a fieldable technique for RNA virus characterization. C1 [Kilianski, Andy; Roth, Pierce A.; Liem, Alvin T.; Hill, Jessica M.; Willis, Kristen L.; Rossmaier, Rebecca D.; Marinich, Andrew V.; Maughan, Michele N.; Karavis, Mark A.; Rosenzweig, C. Nicole] US Army, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. [Willis, Kristen L.] Def Threat Reduct Agcy, Ft Belvoir, VA USA. [Kuhn, Jens H.; Honko, Anna N.] NIH, Frederick, MD USA. RP Rosenzweig, CN (reprint author), Edgewood Chem Biol Ctr, BioSci Div, BioDef Branch, Aberdeen Proving Ground, MD 21010 USA. EM carolyn.n.rosenzweig.civ@mail.mil OI Kilianski, Andy/0000-0002-2350-0142; Honko, Anna/0000-0001-9165-148X FU United States Army; Edgewood Chemical Biological Center Innovative Project [219]; US National Academy of Science; US Defense Threat Reduction Agency as a National Research Council fellow; prime contract of Battelle Memorial Institute, Columbus, Ohio; US National Institute of Allergy and Infectious Diseases [HHSN272200700016I] FX This project was funded through the United States Army and Edgewood Chemical Biological Center 219 Innovative Project initiative to A.K. A.K. is also supported by the US National Academy of Science and the US Defense Threat Reduction Agency as a National Research Council fellow. A.K. is part of the Oxford Nanopore MinION Access Program, and has received free materials for this research. This work was funded in part through the prime contract of Battelle Memorial Institute, Columbus, Ohio, with the US National Institute of Allergy and Infectious Diseases under Contract no. HHSN272200700016I. A subcontractor to Battelle Memorial Institute who performed this work is: J.H.K., an employee of Tunnell Government Services, Inc, Bethesda, MD. Information in this report is cleared for public release and distribution is unlimited. NR 15 TC 3 Z9 3 U1 3 U2 3 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD AUG PY 2016 VL 22 IS 8 BP 1448 EP 1451 DI 10.3201/eid2208.160270 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA DY2PM UT WOS:000384934500017 PM 27191483 ER PT J AU Nafari, RH Ngo, T Lehman, W AF Nafari, R. Hasanzadeh Ngo, T. Lehman, W. TI Development and evaluation of FLFA(cs) - A new Flood Loss Function for Australian commercial structures SO INTERNATIONAL JOURNAL OF DISASTER RISK REDUCTION LA English DT Article DE Flood damage assessment; Commercial structures; Risk reduction; Flood Loss Function; Flood risk assessment ID DAMAGE ESTIMATION; RESIDENTIAL AREAS; MODEL; BUILDINGS; UNCERTAINTY; VALIDATION; MANAGEMENT; DISASTERS; FLEMOCS; CURVES AB Commercial building flood losses significantly affect the Australian economy; however, there are not many models for commercial flood damage estimation and their results are not reliable. This study has attempted to derive and develop a new model (FLFA(CS)) for estimating the magnitude of direct damage on commercial structures. The FLFA(CS) - Flood Loss Function for Australian commercial structures, was calibrated using empirical data collected from the 2013 flood in Bundaberg, Australia, and considering the inherent uncertainty in the data sample. In addition, the newly derived model has been validated using a K-fold cross-validation procedure. The model performance has also been compared with the Flood Loss Estimation MOdel for the commercial sector (FLEMOCS) and the Federal Emergency Management Agency (FEMA) damage functions from overseas, as well as the ANUFLOOD damage model from Australia. The validation procedure shows very good results for FLFA(CS), performance (no bias and only five per cent mean absolute error). It also shows that ANUFLOOD, as Australia's most prevalently used commercial loss estimation model, is still subject to very high uncertainty. Hence, there is an immediate need for a project to build new depth damage functions for commercial and industrial properties. Awareness of these issues is important for strategic decision-making in flood risk reduction and it could amplify the cognition of decision-makers and insurance companies about flood risk assessment in Australia. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Nafari, R. Hasanzadeh] Univ Melbourne, Dept Infrastruct Engn, CDMPS, Melbourne, Vic, Australia. [Ngo, T.] Univ Melbourne, Dept Infrastruct Engn, Adv Protect Technol Engn Struct APTES Grp, Melbourne, Vic, Australia. [Lehman, W.] USACE, Inst Water Resources, Hydrol Engn Ctr, Davis, CA USA. RP Nafari, RH (reprint author), Univ Melbourne, Dept Infrastruct Engn, CDMPS, Melbourne, Vic, Australia. EM rhasanzadeh@student.unimelb.edu.au OI Hasanzadeh Nafari, Roozbeh/0000-0002-3987-4974 FU Bushfire and Natural Hazards CRC FX We would like to thank the Queensland Reconstruction Authority for their kind support and for providing us with invaluable resources and data sets. Also, the authors would like to acknowledge the ongoing financial contribution and support from the Bushfire and Natural Hazards CRC. NR 64 TC 1 Z9 1 U1 1 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 2212-4209 J9 INT J DISAST RISK RE JI Int. J. Disaster Risk Reduct. PD AUG PY 2016 VL 17 BP 13 EP 23 DI 10.1016/j.ijdrr.2016.03.007 PG 11 WC Geosciences, Multidisciplinary; Meteorology & Atmospheric Sciences; Water Resources SC Geology; Meteorology & Atmospheric Sciences; Water Resources GA DY1EG UT WOS:000384837100002 ER PT J AU Demers, KR Makedonas, G Buggert, M Eller, MA Ratcliffe, SJ Goonetilleke, N Li, CK Eller, LA Rono, K Maganga, L Nitayaphan, S Kibuuka, H Routy, JP Slifka, MK Haynes, BF McMichael, AJ Bernard, NF Robb, ML Betts, MR AF Demers, Korey R. Makedonas, George Buggert, Marcus Eller, Michael A. Ratcliffe, Sarah J. Goonetilleke, Nilu Li, Chris K. Eller, Leigh Anne Rono, Kathleen Maganga, Lucas Nitayaphan, Sorachai Kibuuka, Hannah Routy, Jean-Pierre Slifka, Mark K. Haynes, Barton F. McMichael, Andrew J. Bernard, Nicole F. Robb, Merlin L. Betts, Michael R. TI Temporal Dynamics of CD8(+) T Cell Effector Responses during Primary HIV Infection SO PLOS PATHOGENS LA English DT Article ID TRANSCRIPTION FACTOR EOMESODERMIN; VIRUS TYPE-1 INFECTION; ACUTE HEPATITIS-B; FUNCTIONAL-HETEROGENEITY; IMMUNE-RESPONSES; VIRAL-INFECTION; C VIRUS; MEMORY; LYMPHOCYTES; BET AB The loss of HIV-specific CD8(+) T cell cytolytic function is a primary factor underlying progressive HIV infection, but whether HIV-specific CD8(+) T cells initially possess cytolytic effector capacity, and when and why this may be lost during infection, is unclear. Here, we assessed CD8(+) T cell functional evolution from primary to chronic HIV infection. We observed a profound expansion of perforin(+) CD8(+) T cells immediately following HIV infection that quickly waned after acute viremia resolution. Selective expression of the effector-associated transcription factors T-bet and eomesodermin in cytokine-producing HIV-specific CD8(+) T cells differentiated HIV-specific from bulk memory CD8(+) T cell effector expansion. As infection progressed expression of perforin was maintained in HIV-specific CD8(+) T cells with high levels of T-bet, but not necessarily in the population of T-betLo HIV-specific CD8(+) T cells that expand as infection progresses. Together, these data demonstrate that while HIV-specific CD8(+) T cells in acute HIV infection initially possess cytolytic potential, progressive transcriptional dysregulation leads to the reduced CD8(+) T cell perforin expression characteristic of chronic HIV infection. C1 [Demers, Korey R.; Makedonas, George; Buggert, Marcus; Betts, Michael R.] Univ Penn, Dept Microbiol, Perelman Sch Med, Philadelphia, PA 19104 USA. [Buggert, Marcus] Karolinksa Univ Hosp Huddinge, Karolinska Inst, Dept Med, Ctr Infect Med, Stockholm, Sweden. [Eller, Michael A.; Eller, Leigh Anne; Robb, Merlin L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Eller, Michael A.; Eller, Leigh Anne; Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Ratcliffe, Sarah J.] Univ Penn, Perelman Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA. [Goonetilleke, Nilu; Li, Chris K.] Univ Oxford, Weatherall Inst Mol Med, Med Res Council Human Immunol Unit, Oxford, England. [Rono, Kathleen] Kenya Govt Med Res Ctr, Walter Reed Project Kenya, Kericho, Kenya. [Maganga, Lucas] Mbeya Med Res Ctr, Mbeya, Tanzania. [Nitayaphan, Sorachai] USAMC AFRIMS, Dept Retrovirol, Bangkok, Thailand. [Kibuuka, Hannah] Makerere Univ, Sch Med, Makerere Univ Walter Reed Project, Kampala, Uganda. [Routy, Jean-Pierre] McGill Univ, Ctr Hlth, Div Hematol, Montreal, PQ, Canada. [Routy, Jean-Pierre] McGill Univ, Ctr Hlth, Chron Viral Illness Serv, Montreal, PQ, Canada. [Slifka, Mark K.] Oregon Hlth & Sci Univ, Div Neurosci, Oregon Natl Primate Res Ctr, Beaverton, OR USA. [Haynes, Barton F.] Duke Univ, Duke Human Vaccine Inst, Durham, NC USA. [McMichael, Andrew J.] Univ Oxford, NDM Res Bldg,Old Rd Campus, Oxford, England. [Bernard, Nicole F.] McGill Univ, Ctr Hlth, Res Inst, Montreal, PQ, Canada. [Makedonas, George] Texas Childrens Hosp, Dept Pediat, Feigin Ctr, Houston, TX 77030 USA. [Goonetilleke, Nilu] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC USA. RP Betts, MR (reprint author), Univ Penn, Dept Microbiol, Perelman Sch Med, Philadelphia, PA 19104 USA. EM betts@mail.med.upenn.edu FU National Institutes of Health [AI076066, P30 AI045008]; National Institute of Allergy and Infectious Diseases Center for HIV/AIDS Vaccine Immunology [AI067854]; Fonds de la Recherche Quebec-Sante (FRQ-S): Reseau SIDA/Maladies infectieuses; Canadian Institutes of Health Research [MOP 103230, CTN 257]; Canadian HIV Cure Enterprise Team Grant from the CIHR [HIG-133050]; CANFAR FX This work was supported by grants from the National Institutes of Health (AI076066 to MRB and P30 AI045008 to the Center for AIDS Research at the University of Pennsylvania), the National Institute of Allergy and Infectious Diseases Center for HIV/AIDS Vaccine Immunology (AI067854 to AJM), the Fonds de la Recherche Quebec-Sante (FRQ-S): Reseau SIDA/Maladies infectieuses, the Canadian Institutes of Health Research (MOP 103230 and CTN 257), and the Canadian HIV Cure Enterprise Team Grant HIG-133050 from the CIHR in partnership with CANFAR. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 75 TC 1 Z9 1 U1 1 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-7366 EI 1553-7374 J9 PLOS PATHOG JI PLoS Pathog. PD AUG PY 2016 VL 12 IS 8 AR e1005805 DI 10.1371/journal.ppat.1005805 PG 24 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA DW1AV UT WOS:000383376000036 PM 27486665 ER PT J AU Pecht, M Shibutani, T Kang, M Hodkiewicz, M Cripps, E AF Pecht, Michael Shibutani, Tadahiro Kang, Myeongsu Hodkiewicz, Melinda Cripps, Edward TI A fusion prognostics-based qualification test methodology for microelectronic products SO MICROELECTRONICS RELIABILITY LA English DT Review DE Microelectronics; Physics-of-failure; Prognostics; Qualification testing; Reliability ID FAILURE-MECHANISM MODELS; IDENTIFICATION; ELECTRONICS AB The global market for microelectronic products is projected to reach US$2.4 trillion per year by 2020. This growth has led to intense competition between manufacturers to minimize the time-to-market for their products. Unfortunately, however, qualification testing, which is time-consuming and resource-intensive, is a major bottleneck for the quick release of microelectronic products to the market. Hence, for both researchers and engineers considering the time with reliability issues during qualification testing, this paper provides a review of conventional methodologies in qualification testing and presents a fusion prognostics-based qualification test methodology that combines the advantages of physics-of-failure and data-driven methods. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Pecht, Michael] IEEE, USA, Washington, DC USA. [Pecht, Michael] Univ Maryland, Ctr Adv Life Cycle Engn, College Pk, MD 20742 USA. [Pecht, Michael; Shibutani, Tadahiro; Kang, Myeongsu] Yokohama Natl Univ, Yokohama, Kanagawa 2408501, Japan. [Hodkiewicz, Melinda] Univ Western Australia, Sch Mech & Chem Engn, Crawley, WA, Australia. [Cripps, Edward] Univ Western Australia, Sch Math & Stat, Crawley, WA, Australia. RP Pecht, M (reprint author), Univ Maryland, Ctr Adv Life Cycle Engn, College Pk, MD 20742 USA. EM pecht@calce.umd.edu; shibu@ynu.jp; mskang@calce.umd.edu; Melinda.hodkiewicz@uwa.edu.au; Edward.cripps@uwa.edu.au FU NSFC [71420107023] FX The research was supported by the over 100 CALCE members of the CALCE Consortium and by the NSFC under grant number 71420107023. NR 51 TC 0 Z9 0 U1 8 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0026-2714 J9 MICROELECTRON RELIAB JI Microelectron. Reliab. PD AUG PY 2016 VL 63 BP 320 EP 324 DI 10.1016/j.microrel.2016.04.002 PG 5 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA DY0GV UT WOS:000384776200041 ER PT J AU Gong, P Perkins, EJ AF Gong, Ping Perkins, Edward J. TI Earthworm toxicogenomics: A renewed genome-wide quest for novel biomarkers and mechanistic insights SO APPLIED SOIL ECOLOGY LA English DT Article; Proceedings Paper CT 10th International Symposium on Earthworm Ecology (ISEE) CY JUN, 2014 CL Athens, GA DE Earthworm; Biomarker; Toxicological mechanism; Toxicogenomics; Toxicotranscriptomics; Toxicoproteomics; Toxicometabolomics ID NMR-BASED METABOLOMICS; EXPRESSED SEQUENCE TAGS; SUBLETHAL PHENANTHRENE EXPOSURE; ADVERSE OUTCOME PATHWAYS; EISENIA-FOETIDA; LUMBRICUS-RUBELLUS; GENE-EXPRESSION; H-1-NMR METABOLOMICS; ENDOSULFAN EXPOSURE; RISK-ASSESSMENT AB As sentinel species, earthworms such as Eisenia spp. and Lumbricus spp. have been considered among the best bioindicators or biomonitors for soil ecosystems owing to their close contact with the environment and essential roles in soil pedogenesis, structure, fertility and the terrestrial food chain. Earthworms have also been used extensively for assessing environmental risk and chemical toxicity in laboratory and field settings. In the past two decades, a comprehensive set of transcriptomic, proteomic, metabolomic and bioinformatic tools have been developed and applied to assess ecological impacts of contaminated soils on earthworms. In this review, we summarize recent progress made in earthworm toxicogenomics, with an emphasis on earthworm toxicotranscriptomics, examine novel biomarkers discovered and mechanistic insights gained through toxicogenomics studies, discuss currently existing technical hurdles to be resolved in order to move ahead, and finally provide some remarks on the future perspectives of this interdisciplinary and promising field. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license. C1 [Gong, Ping; Perkins, Edward J.] US Army, Environm Lab, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. RP Gong, P (reprint author), US Army, Environm Lab, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM ping.gong@usace.army.mil NR 129 TC 0 Z9 0 U1 13 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0929-1393 EI 1873-0272 J9 APPL SOIL ECOL JI Appl. Soil Ecol. PD AUG PY 2016 VL 104 BP 12 EP 24 DI 10.1016/j.apsoil.2015.11.005 PG 13 WC Soil Science SC Agriculture GA DX2XT UT WOS:000384237600003 ER PT J AU Kuperman, RG Simini, M Checkai, RT Dodard, SG Sarrazin, M Hawari, J Paquet, L Sunahara, GI Di Toro, DM Allen, HE Kuo, DTF Torralba-Sanchez, TL AF Kuperman, Roman G. Simini, Mike Checkai, Ronald T. Dodard, Sabine G. Sarrazin, Manon Hawari, Jalal Paquet, Louise Sunahara, Geoffrey I. Di Toro, Dominic M. Allen, Herbert E. Kuo, Dave Ta Fu Torralba-Sanchez, Tifany L. TI Developing earthworm bioconcentration factors of nitrogen-based compounds for predicting environmentally significant parameters for new munition compounds in soil SO APPLIED SOIL ECOLOGY LA English DT Article; Proceedings Paper CT 10th International Symposium on Earthworm Ecology (ISEE) CY JUN, 2014 CL Athens, GA DE Munition compounds; Bioconcentration; Toxicity; Earthworms ID EISENIA-ANDREI; 2,4,6-TRINITROTOLUENE TNT; BIOACCUMULATION; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE; TOXICITY; BIOAVAILABILITY; ACCUMULATION; OLIGOCHAETA; CHEMICALS; BEHAVIOR AB We investigated the bioconcentration potential of nitrogen-based compounds 4-nitroanisole (4-NAN), 3,5-dinitro-o-toluamide (3,5-DNoTAME), and 2-methoxy-5 nitropyridine (2-M-5-NPYNE) using earthworm Eisenia andrei exposures in aqueous exposure media in sand. Separate toxicity studies were conducted prior to bioconcentration studies using a range of chemical concentrations to establish the sublethal exposure conditions for the earthworms. The objectives of the present studies were to: (1) develop an experimental test system for estimating bioconcentration potentials of new and emerging munition compounds that partition into earthworms, using aqueous exposure media; and (2) apply this experimental model to establish original bioconcentration data for 4-NAN, 3,5-DNoTAME, and 2-M-5-NPYNE. Experimental design includes earthworm exposures to chemicals for up to 14 days in aqueous media (Rombke medium; 0.08 mM KCl, 2 mM CaCl2, 0.5 mM MgSO4, and 0.8 mM NaHCO3) in the presence of water-washed coarse sand (0.5-1.0 mm) substrate. Concentrations of test chemicals in respective exposure media remained relatively stable during these independent studies. Tissue analyses revealed a rapid uptake of each chemical by the earthworms; a steady state was attained within 24 h from commencement of these exposures. Estimated steady-state bioconcentration factors (BCFss; mL/g dry tissue) were 47, 6, and 11 for 4-NAN, 3,5-DNoTAME, and 2-M-5-NPYNE, respectively. These results will contribute to the BCF database being developed for use in models aimed at predicting environmentally significant parameters for new munition compounds in soil. Published by Elsevier B.V. C1 [Kuperman, Roman G.; Simini, Mike; Checkai, Ronald T.] US Army, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Dodard, Sabine G.; Sarrazin, Manon; Hawari, Jalal; Paquet, Louise; Sunahara, Geoffrey I.] Natl Res Council Canada, Montreal, PQ H4P 2R2, Canada. [Hawari, Jalal] Polytech Montreal, Dept Civil Geol & Min Engn, Montreal, PQ H3C 3A7, Canada. [Sunahara, Geoffrey I.] McGill Univ, Dept Nat Resource Sci, Ste Anne De Bellevue, PQ H9X 3V9, Canada. [Di Toro, Dominic M.; Allen, Herbert E.; Torralba-Sanchez, Tifany L.] Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. [Kuo, Dave Ta Fu] City Univ Hong Kong, Dept Architecture & Civil Engn, Hong Kong, Hong Kong, Peoples R China. RP Kuperman, RG (reprint author), US Army, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM roman.g.kuperman.civ@mail.mil OI Kuo, Dave Ta Fu/0000-0002-7162-174X NR 29 TC 0 Z9 0 U1 4 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0929-1393 EI 1873-0272 J9 APPL SOIL ECOL JI Appl. Soil Ecol. PD AUG PY 2016 VL 104 BP 25 EP 30 DI 10.1016/j.apsoil.2015.11.008 PG 6 WC Soil Science SC Agriculture GA DX2XT UT WOS:000384237600004 ER PT J AU Elder, T Woodley, CM Weiland, MA Strecker, AL AF Elder, Timothy Woodley, Christa M. Weiland, Mark A. Strecker, Angela L. TI Factors influencing the survival of outmigrating juvenile salmonids through multiple dam passages: an individual-based approach SO ECOLOGY AND EVOLUTION LA English DT Article DE Acoustic transmitters; Chinook salmon; dissolved gas; involuntary spill; random forest; steelhead trout ID DISSOLVED-GAS SUPERSATURATION; SUMMER CHINOOK SALMON; SNAKE RIVER; FRESH-WATER; ONCORHYNCHUS-TSHAWYTSCHA; DELAYED MORTALITY; PACIFIC-NORTHWEST; COLUMBIA RIVERS; STEELHEAD; SYSTEMS AB Substantial declines of Pacific salmon populations have occurred over the past several decades related to large-scale anthropogenic and climatic changes in freshwater and marine environments. In the Columbia River Basin, migrating juvenile salmonids may pass as many as eight large-scale hydropower projects before reaching the ocean; however, the cumulative effects of multiple dam passages are largely unknown. Using acoustic transmitters and an extensive system of hydrophone arrays in the Lower Columbia River, we calculated the survival of yearling Chinook salmon (Oncorhynchus tshawytscha) and steelhead (O. mykiss) passing one, two, or three dams. We applied a unique index of biological characteristics and environmental exposures, experienced by each fish individually as it migrated downstream, in order to examine which factors most influence salmonid survival. High outflow volumes led to involuntary spill in 2011 and created an environment of supersaturated dissolved gas concentrations. In this environment, migrating smolt survival was strongly influenced by barometric pressure, fish velocity, and water temperature. The effect of these variables on survival was compounded by multiple dam passages compared to fish passing a single dam. Despite spatial isolation between dams in the Lower Columbia River hydrosystem, migrating smolt appear to experience cumulative effects akin to a press disturbance. In general, Chinook salmon and steelhead respond similarly in terms of survival rates and responses to altered environmental conditions. Management actions that limit dissolved gas concentrations in years of high flow will benefit migrating salmonids at this life stage. C1 [Elder, Timothy; Strecker, Angela L.] Portland State Univ, Dept Environm Sci & Management, POB 751, Portland, OR 97207 USA. [Woodley, Christa M.] US Army, Environm Lab, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. [Weiland, Mark A.] Pacific Northwest Natl Lab, 390 Evergreen Dr,POB 241, North Bonneville, WA 98639 USA. RP Elder, T (reprint author), Portland State Univ, Dept Environm Sci & Management, POB 751, Portland, OR 97207 USA. EM telder@pdx.edu FU National Science Foundation Cascades to Coast GK-12 program [0948041] FX National Science Foundation Cascades to Coast GK-12 program, (Grant/Award Number: "0948041"). NR 43 TC 0 Z9 0 U1 18 U2 18 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2045-7758 J9 ECOL EVOL JI Ecol. Evol. PD AUG PY 2016 VL 6 IS 16 BP 5881 EP 5892 DI 10.1002/ece3.2326 PG 12 WC Ecology; Evolutionary Biology SC Environmental Sciences & Ecology; Evolutionary Biology GA DT6FF UT WOS:000381578400026 PM 27547362 ER PT J AU Park, J Pagan-Vazquez, A Alvarado, JL Chamorro, LP Lux, S Marsh, C AF Park, Jeongmoon Pagan-Vazquez, Axy Alvarado, Jorge L. Chamorro, Leonardo P. Lux, Scott Marsh, Charles TI Experimental and Numerical Visualization of Counter Rotating Vortices SO JOURNAL OF HEAT TRANSFER-TRANSACTIONS OF THE ASME LA English DT News Item C1 [Park, Jeongmoon; Alvarado, Jorge L.] Texas A&M Univ, College Stn, TX 77843 USA. [Pagan-Vazquez, Axy; Chamorro, Leonardo P.; Marsh, Charles] Univ Illinois, Urbana, IL USA. [Pagan-Vazquez, Axy; Lux, Scott; Marsh, Charles] US Army, Construct Engn Res Lab, Champaign, IL 61824 USA. RP Alvarado, JL (reprint author), Texas A&M Univ, College Stn, TX 77843 USA. EM jorge.alvarado@tamu.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0022-1481 EI 1528-8943 J9 J HEAT TRANS-T ASME JI J. Heat Transf.-Trans. ASME PD AUG PY 2016 VL 138 IS 8 AR 080908 PG 2 WC Thermodynamics; Engineering, Mechanical SC Thermodynamics; Engineering GA DW9HC UT WOS:000383966300010 ER PT J AU Golding, WM AF Golding, William M. TI Quantum modes of atomic waveguides by series techniques SO JOURNAL OF MATHEMATICAL PHYSICS LA English DT Article AB Atom waveguides are used to manipulate cold atoms in atom interferometers. The creation of atom interferometers using cold atoms in miniature magnetic waveguides is one of many goals of current atom chip research. To achieve a complete understanding of atom propagation in a complicated device such as a guided atom interferometer, a detailed understanding of the ground state and other nearby states is needed. The Frobenius series solutions for the bounded transverse modes of an atomic waveguide are presented here and arbitrary precision arithmetic is used to evaluate the series solutions without roundoff errors. The waveguide potential considered is an infinitely long quadrupole magnetic potential as used in various atom chip waveguides. The simplest case of a guided spin-1/2 particle is presented here. However, the basic series techniques can be extended to both higher order multi-pole potentials and higher spin particles, including atoms with hyperfine splitting. The low-field and the high-field seeking states together form the spectrum of the waveguide Hamiltonian. In the limit where the transverse dimension of the guide tends to infinity, the spectrum of the guide changes from a discrete set of low-and high-field seeking states to a continuum of high-field seeking states embedded with a discrete set of low-field seeking states. Although the low-field seeking states are not truly bound, the system is an approximate example of bound states in a continuum first discussed by von Neumann and Wigner. Depending on boundary conditions, the solutions form either a discrete set or a continuum of orthogonal waveguide modes. These are useful for further analysis of ideal waveguide behavior as well as the detailed perturbation studies necessary for analysis of atomic waveguide interferometers. Published by AIP Publishing. C1 [Golding, William M.] US Army Res Lab, Adelphi, MD 20783 USA. RP Golding, WM (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM william.m.golding2.civ@mail.mil NR 17 TC 0 Z9 0 U1 4 U2 4 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0022-2488 EI 1089-7658 J9 J MATH PHYS JI J. Math. Phys. PD AUG PY 2016 VL 57 IS 8 AR 082107 DI 10.1063/1.4960458 PG 15 WC Physics, Mathematical SC Physics GA DW8PF UT WOS:000383917300029 ER PT J AU Robertson, JM Rodriguez, RX Holmes, LR Mather, PT Wetzel, ED AF Robertson, J. M. Rodriguez, R. X. Holmes, L. R., Jr. Mather, P. T. Wetzel, E. D. TI Thermally driven microfluidic pumping via reversible shape memory polymers SO SMART MATERIALS AND STRUCTURES LA English DT Article DE shape memory polymer; microfluidic pump; reversible flow; thermally driven flow ID CROSS-LINKED EPOXY; THERMOMECHANICAL PROPERTIES; MAGNETIC NANOPARTICLES; THIN-FILMS; BULGE TEST; FABRICATION; ACTUATION; BEHAVIOR; DEVICES AB The need exists for autonomous microfluidic pumping systems that utilize environmental cues to transport fluid within a network of channels for such purposes as heat distribution, self-healing, or optical reconfiguration. Here, we report on reversible thermally driven microfluidic pumping enabled by two-way shape memory polymers. After developing a suitable shape memory polymer (SMP) through variation in the crosslink density, thin and flexible microfluidic devices were constructed by lamination of plastic films with channels defined by laser-cutting of double-sided adhesive film. SMP blisters integrated into the devices provide thermally driven pumping, while opposing elastic blisters are used to generate backpressure for reversible operation. Thermal cycling of the device was found to drive reversible fluid flow: upon heating to 60 degrees C, the SMP rapidly contracted to fill the surface channels with a transparent fluid, and upon cooling to 8 degrees C the flow reversed and the channel re-filled with black ink. Combined with a metallized backing layer, this device results in refection of incident light at high temperatures and absorption of light (at the portions covered with channels) at low temperatures. We discuss power-free, autonomous applications ranging from thermal regulation of structures to thermal indication via color change. C1 [Robertson, J. M.; Rodriguez, R. X.; Holmes, L. R., Jr.; Wetzel, E. D.] US Army Res Lab, Mat & Mfg Sci Div, Aberdeen Proving Ground, MD 21005 USA. [Mather, P. T.] Syracuse Univ, Syracuse Biomat Inst, Syracuse, NY 13244 USA. [Mather, P. T.] Dept Biomed & Chem Engn, Syracuse, NY 13244 USA. RP Mather, PT (reprint author), Syracuse Univ, Syracuse Biomat Inst, Syracuse, NY 13244 USA.; Mather, PT (reprint author), Dept Biomed & Chem Engn, Syracuse, NY 13244 USA. EM patrick.mather@bucknell.edu; eric.d.wetzel2.civ@mail.mil NR 37 TC 1 Z9 1 U1 22 U2 22 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0964-1726 EI 1361-665X J9 SMART MATER STRUCT JI Smart Mater. Struct. PD AUG PY 2016 VL 25 IS 8 AR 085043 DI 10.1088/0964-1726/25/8/085043 PG 13 WC Instruments & Instrumentation; Materials Science, Multidisciplinary SC Instruments & Instrumentation; Materials Science GA DV9QD UT WOS:000383275000063 ER PT J AU Arballo, OM Beachkofsky, TM Kobayashi, TT AF Arballo, Olivia M. Beachkofsky, Thomas M. Kobayashi, Todd T. TI Enlarging Breast Lesion The Diagnosis: Radiation-Associated Angiosarcoma SO CUTIS LA English DT Editorial Material ID ANTI-MYC IMMUNOHISTOCHEMISTRY; ATYPICAL VASCULAR-LESIONS; AMPLIFICATION; RADIOTHERAPY; CANCER C1 [Arballo, Olivia M.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Beachkofsky, Thomas M.; Kobayashi, Todd T.] Wilford Hall Ambulatory Surg Ctr, Lackland Air Force Base, TX USA. RP Arballo, OM (reprint author), Lake Erie Coll Osteopath Med, 1858 W Grandview Blvd, Erie, PA 16509 USA. EM olivia.thimmig@med.lecom.edu NR 7 TC 0 Z9 0 U1 0 U2 0 PU QUADRANT HEALTHCOM INC PI PARSIPPANY PA 7 CENTURY DRIVE, STE 302, PARSIPPANY, NJ 07054-4603 USA SN 0011-4162 EI 2326-6929 J9 CUTIS JI Cutis PD AUG PY 2016 VL 98 IS 2 BP E12 EP E14 PG 3 WC Dermatology SC Dermatology GA DV8TX UT WOS:000383210700005 PM 27622261 ER PT J AU Greene, WA Burke, TA Por, ED Kaini, RR Wang, HC AF Greene, Whitney A. Burke, Teresa A. Por, Elaine D. Kaini, Ramesh R. Wang, Heuy-Ching TI Secretion Profile of Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium During Wound Healing SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Article DE EMT; epithelium-mesenchymal transition; induced pluripotent stem cell-derived retinal pigment epithelium; iPS-RPE; proliferative vitreoretinopathy; PVR; wound healing ID MESENCHYMAL TRANSITION; GROWTH-FACTOR; PROLIFERATIVE VITREORETINOPATHY; BETA-CATENIN; PDGF-C; EXPRESSION; ACTIVATION; MECHANISMS; TGF-BETA-1; CYTOKINES AB PURPOSE. The purpose of this study was to characterize the secretion profile of induced pluripotent stem cell-derived retinal pigment epithelium (iPS-RPE) during wound healing. iPS-RPE was used to develop an in vitro wound healing model. We hypothesized that iPS-RPE secretes cytokines and growth factors which act in an autocrine manner to promote migration and proliferation of cells during wound healing. METHODS. iPS-RPE was grown in transwells until fully confluent and pigmented. The monolayers were scratched to induce a wound. Levels of Ki-67, beta-catenin, e-cadherin, n-cadherin, and S100A4 expression were analyzed by immunofluorescent labeling. Cell culture medium samples were collected from both the apical and basolateral sides of the transwells every 72 hours for 21 days. The medium samples were analyzed using multiplex ELISA to detect secreted growth factors and cytokines. The effects of conditioned medium on collagen gel contraction, cell proliferation, and migration were measured. RESULTS. iPS-RPE underwent epithelial-mesenchymal transition (EMT) during wound healing as indicated by the translocation of beta-catenin to the nucleus, cadherin switch, and expression of S100A4. GRO, GM-CSF, MCP-1, IL-6, and IL-8 were secreted by both the control and the wounded cell cultures. VEGF, FGF-2, and TGF beta expression were detected at higher levels after wounding than those in control. The proteins were found to be secreted in a polarized manner. The conditioned medium from wounded monolayers promoted collagen gel contraction, as well as proliferation and migration of ARPE 19 cells. CONCLUSIONS. These results indicate that after the monolayer is wounded, iPS-RPE secretes proteins into the culture medium that promote increased proliferation, contraction, and migration. C1 [Greene, Whitney A.; Burke, Teresa A.; Por, Elaine D.; Kaini, Ramesh R.; Wang, Heuy-Ching] US Army Inst Surg Res, Ocular Trauma Task Area, Joint Base San Antonio F, TX USA. RP Greene, WA; Wang, HC (reprint author), US Army Inst Surg Res, Ocular Trauma, 3698 Chambers Pass,Bldg 3611, Jbsa Ft Sam Houston, TX 78234 USA. EM whitney.a.greene2.vol@mail.mil; heuy-ching.h.wang.civ@mail.mil FU US Army Clinical Rehabilitative Medicine Research Program; Military Operational Medicine Research Program; National Research Council FX Supported by US Army Clinical Rehabilitative Medicine Research Program, Military Operational Medicine Research Program, National Research Council (WAG, RRK). NR 48 TC 0 Z9 0 U1 4 U2 4 PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC PI ROCKVILLE PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA SN 0146-0404 EI 1552-5783 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD AUG PY 2016 VL 57 IS 10 BP 4428 EP 4441 DI 10.1167/iovs.16-19192 PG 14 WC Ophthalmology SC Ophthalmology GA DW9LR UT WOS:000383981600062 PM 27750286 ER PT J AU Edwards, AE Johnson, E Coor, JL Jagoe, CH Sachi-Kocher, A Kenney, WF AF Edwards, Amy E. Johnson, Elijah Coor, Jennifer L. Jagoe, Charles H. Sachi-Kocher, Afi Kenney, William F. TI HISTORICAL RECORD OF ATMOSPHERIC DEPOSITION OF METALS AND delta N-15 IN AN OMBROTROPHIC KARST SINKHOLE FEN, SOUTH CAROLINA, USA SO JOURNAL OF CAVE AND KARST STUDIES LA English DT Article ID ISOTOPE COMPOSITION; MERCURY DEPOSITION; ORGANIC-MATTER; POLLUTION HISTORY; LAKE-SEDIMENTS; WATER; LEAD; CONTAMINATION; CHRONOLOGY; ONTARIO AB Radiometric Pb-210 dating, metal concentrations [As, Cd, Cr, Cu, Hg, Pb and Zn] and nitrogen-isotope (delta N-15) analyses were conducted on a sediment core from an ombrotrophic karst sinkhole fen in South Carolina, USA, to obtain a historical record of nitrogen signatures and atmospherically deposited metals from increased anthropogenic emissions during the last several decades. Sinkhole fens in carbonate karst terrains are excellent environs for sediment core dating and metal analysis due to the low background metal concentrations in carbonates, as well as the alkaline nature of carbonates and the high organic-matter content in fens, both of which reduce mobility of metals in soils. Metal concentrations were found for the top twenty 1 cm intervals of the core and the bottom at 56 cm. Intervals 21-55 cm were analyzed only for Hg and organic-matter content due to financial constraints. The sinkhole fen in the study is ombrotrophic and receives metal inputs primarily through wet and dry atmospheric deposition, and the 20 cm deep sample had a Pb-210 CRS age of 1954. Metals with significant (p < 0.05) negative correlations with core depth were (negative correlation, sample size): Hg (-0.8948, n = 56), Pb (-0.9308, n = 21), Zn (-0.6299, n = 21), Cd (-0.5023, n = 21), and Cu (-0.5156, n = 21). In view of the low background concentrations of these five metals from limestone found in the sinkhole, atmospheric deposition from anthropogenic emissions is likely the predominant source for these increasing concentrations. As (+0.4431, n = 21) had a significant (p < 0.05) positive correlation with core depth, while Cr (+0.2761, n = 21) was the only metal with no significant correlation with core depth. Although delta N-15 is shown in other studies to deplete upward in sediment cores due to increasing reactive nitrogen emissions, the sinkhole core in this study had no significant correlation (+0.2580, n = 21) between delta N-15 and depth. Total carbon, total nitrogen, total phosphorus, and organic-matter content were also measured in intervals 1-20 and 56 cm and found to have several significant (p < 0.05) correlations with depth, metals, and delta N-15. C1 [Edwards, Amy E.] Hanover Cty Govt, Hanover, VA 23116 USA. [Johnson, Elijah; Jagoe, Charles H.] Florida A&M Univ, Sch Environm, Tallahassee, FL 32307 USA. [Coor, Jennifer L.] US Army, Corps Engineers, Jacksonville, FL 32207 USA. [Sachi-Kocher, Afi] Florida State Univ, Natl High Magnet Field Lab, Tallahassee, FL 32306 USA. [Kenney, William F.] Univ Florida, Land Use & Environm Change Inst, Gainesville, FL 32611 USA. RP Edwards, AE (reprint author), Hanover Cty Govt, Hanover, VA 23116 USA. EM aeedwards@hanovercounty.gov FU National Oceanic and Atmospheric Administration's Education Partnership Program [NA60AAR4810164]; Environmental Cooperative Science Center housed at Florida AM University FX Funding for the project was provided by the National Oceanic and Atmospheric Administration's Education Partnership Program through a cooperative agreement (NA60AAR4810164) with the Environmental Cooperative Science Center housed at Florida A&M University. The authors would like to thank Valerie-Carter Stone with the South Carolina Department of Parks, Recreation and Tourism for permit N-16-12 to sample the sinkhole in Santee State Park. We also thank Dan Phelps and Harvey Guy Means at the Florida Geological Survey; Steven Petrushak and Dr. Charlotte Sjunneskog at the Florida State University Antarctic Research Facility; Angela Dial at National High Magnetic Field Laboratory; William Burnett at Florida State University Department of Oceanography; Mark Malsick of South Carolina Department of Natural Resources; Henry Porter and Elzbieta Covington at South Carolina Department of Health and Environmental Control; and Christy Crandall at Florida A&M University. The authors would also like to thank Benjamin Schwartz and anonymous reviewers for improving the manuscript. NR 40 TC 0 Z9 0 U1 1 U2 1 PU NATL SPELEOLOGICAL SOC PI HUNTSVILLE PA 2813 CAVE AVE, HUNTSVILLE, AL 35810-4431 USA SN 1090-6924 EI 2331-3714 J9 J CAVE KARST STUD JI J. Cave Karst Stud. PD AUG PY 2016 VL 78 IS 2 BP 85 EP 93 DI 10.4311/2014ES0109 PG 9 WC Geosciences, Multidisciplinary SC Geology GA DW7GX UT WOS:000383820300004 ER PT J AU Hardick, J Woelfel, R Gardner, W Ibrahim, S AF Hardick, Justin Woelfel, Roman Gardner, Warren Ibrahim, Sofi TI Sequencing Ebola and Marburg Viruses Genomes Using Microarrays SO JOURNAL OF MEDICAL VIROLOGY LA English DT Article DE Ebola virus; Marburg virus; microarrays ID HEMORRHAGIC-FEVER; IDENTIFICATION; AMPLIFICATION; DIAGNOSTICS; OUTBREAK AB Periodic outbreaks of Ebola and Marburg hemorrhagic fevers have occurred in Africa over the past four decades with case fatality rates reaching as high as 90%. The latest Ebola outbreak in West Africa in 2014 raised concerns that these infections can spread across continents and pose serious health risks. Early and accurate identification of the causative agents is necessary to contain outbreaks. In this report, we describe sequencing-by-hybridization (SBH) technique using high density microarrays to identify Ebola and Marburg viruses. The microarrays were designed to interrogate the sequences of entire viral genomes, and were evaluated with three species of Ebolavirus (Reston, Sudan, and Zaire), and three strains of Marburgvirus (Angola, Musoke, and Ravn). The results showed that the consensus sequences generated with four or more hybridizations had 92.1-98.9% accuracy over 95-99% of the genomes. Additionally, with SBH microarrays it was possible to distinguish between different strains of the Lake Victoria Marburgvirus. (C) 2016 Wiley Periodicals, Inc. C1 [Hardick, Justin] Johns Hopkins Univ, Dept Med, Baltimore, MD USA. [Woelfel, Roman] Bundeswehr Inst Microbiol, Munich, Germany. [Gardner, Warren; Ibrahim, Sofi] US Army, Res Dev & Engn Command, Edgewood Chem Biol Ctr, 5183 Blackhawk Rd,Bldg E3549, Aberdeen Proving Ground, MD 21010 USA. RP Ibrahim, S (reprint author), US Army, Res Dev & Engn Command, Edgewood Chem Biol Ctr, 5183 Blackhawk Rd,Bldg E3549, Aberdeen Proving Ground, MD 21010 USA. EM sofi.ibrahim@us.army.mil FU Defense Threat Reduction Agency FX Grant sponsor: Defense Threat Reduction Agency NR 23 TC 0 Z9 0 U1 3 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0146-6615 EI 1096-9071 J9 J MED VIROL JI J. Med. Virol. PD AUG PY 2016 VL 88 IS 8 BP 1303 EP 1308 DI 10.1002/jmv.24487 PG 6 WC Virology SC Virology GA DW5FU UT WOS:000383669500004 PM 26822839 ER PT J AU The, HC Rabaa, MA Thanh, DP De Lappe, N Cormican, M Valcanis, M Howden, BP Wangchuk, S Bodhidatta, L Mason, CJ Nguyen, TNT Thuy, DV Thompson, CN Lan, NPH Vinh, PV Thanh, TH Turner, P Sar, P Thwaites, G Thomson, NR Holt, KE Baker, S AF Hao Chung The Rabaa, Maia A. Duy Pham Thanh De Lappe, Niall Cormican, Martin Valcanis, Mary Howden, Benjamin P. Wangchuk, Sonam Bodhidatta, Ladaporn Mason, Carl J. To Nguyen Thi Nguyen Duong Vu Thuy Thompson, Corinne N. Nguyen Phu Huong Lan Phat Voong Vinh Tuyen Ha Thanh Turner, Paul Sar, Poda Thwaites, Guy Thomson, Nicholas R. Holt, Kathryn E. Baker, Stephen TI South Asia as a Reservoir for the Global Spread of Ciprofloxacin-Resistant Shigella sonnei: A Cross-Sectional Study SO PLOS MEDICINE LA English DT Article ID ANTIMICROBIAL RESISTANCE; DYSENTERY; EPIDEMIC; CHILDREN; INDIA AB Background Antimicrobial resistance is a major issue in the Shigellae, particularly as a specific multidrug-resistant (MDR) lineage of Shigella sonnei (lineage III) is becoming globally dominant. Ciprofloxacin is a recommended treatment for Shigella infections. However, ciprofloxacin-resistant S. sonnei are being increasingly isolated in Asia and sporadically reported on other continents. We hypothesized that Asia is a primary hub for the recent international spread of ciprofloxacin-resistant S. sonnei. Methods and Findings We performed whole-genome sequencing on a collection of 60 contemporaneous ciprofloxacin-resistant S. sonnei isolated in four countries within Asia (Vietnam, n = 11; Bhutan, n = 12; Thailand, n = 1; Cambodia, n = 1) and two outside of Asia (Australia, n = 19; Ireland, n = 16). We reconstructed the recent evolutionary history of these organisms and combined these data with their geographical location of isolation. Placing these sequences into a global phylogeny, we found that all ciprofloxacin-resistant S. sonnei formed a single clade within a Central Asian expansion of lineage III. Furthermore, our data show that resistance to ciprofloxacin within S. sonnei may be globally attributed to a single clonal emergence event, encompassing sequential gyrA-S83L, parC-S80I, and gyrA-D87G mutations. Geographical data predict that South Asia is the likely primary source of these organisms, which are being regularly exported across Asia and intercontinentally into Australia, the United States and Europe. Our analysis was limited by the number of S. sonnei sequences available from diverse geographical areas and time periods, and we cannot discount the potential existence of other unsampled reservoir populations of antimicrobial-resistant S. sonnei. Conclusions This study suggests that a single clone, which is widespread in South Asia, is likely driving the current intercontinental surge of ciprofloxacin-resistant S. sonnei and is capable of establishing endemic transmission in new locations. Despite being limited in geographical scope, our work has major implications for understanding the international transfer of antimicrobial-resistant pathogens, with S. sonnei acting as a tractable model for studying how antimicrobial-resistant Gram-negative bacteria spread globally. C1 [Hao Chung The; Rabaa, Maia A.; Duy Pham Thanh; To Nguyen Thi Nguyen; Duong Vu Thuy; Thompson, Corinne N.; Nguyen Phu Huong Lan; Phat Voong Vinh; Tuyen Ha Thanh; Thwaites, Guy; Baker, Stephen] Univ Oxford, Clin Res Unit, Hosp Trop Dis, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam. [Rabaa, Maia A.; Thompson, Corinne N.; Turner, Paul; Thwaites, Guy; Baker, Stephen] Univ Oxford, Ctr Trop Med & Global Hlth, Oxford, England. [De Lappe, Niall] Univ Hosp Galway, Natl Salmonella Shigella & Listeria Monocytogenes, Galway, Ireland. [Cormican, Martin] Natl Univ Ireland Galway, Sch Med, Galway, Ireland. [Valcanis, Mary; Howden, Benjamin P.] Univ Melbourne, Dept Microbiol & Immunol, Peter Doherty Inst Infect & Immun, Publ Hlth Lab,Microbiol Diagnost Unit, Melbourne, Vic, Australia. [Wangchuk, Sonam] Royal Govt Bhutan, Dept Publ Hlth, Publ Hlth Lab, Minist Hlth, Thimphu, Bhutan. [Bodhidatta, Ladaporn; Mason, Carl J.] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok, Thailand. [Nguyen Phu Huong Lan] Hosp Trop Dis, Ho Chi Minh City, Vietnam. [Turner, Paul; Sar, Poda] Angkor Hosp Children, Cambodia Oxford Med Res Unit, Siem Reap, Cambodia. [Thomson, Nicholas R.] London Sch Hyg & Trop Med, London, England. [Thomson, Nicholas R.; Baker, Stephen] Wellcome Trust Sanger Inst, Hinxton, Cambs, England. [Holt, Kathryn E.] Univ Melbourne, Ctr Syst Genom, Melbourne, Vic, Australia. [Holt, Kathryn E.] Univ Melbourne, Dept Biochem & Mol Biol, Mol Sci & Biotechnol Inst Bio21, Melbourne, Vic, Australia. RP Baker, S (reprint author), Univ Oxford, Clin Res Unit, Hosp Trop Dis, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam.; Baker, S (reprint author), Univ Oxford, Ctr Trop Med & Global Hlth, Oxford, England.; Baker, S (reprint author), Wellcome Trust Sanger Inst, Hinxton, Cambs, England. EM sbaker@oucru.org OI MASON, CARL/0000-0002-3676-2811; Chung, Hao/0000-0002-4028-4074; Rabaa, Maia/0000-0003-0529-2228 FU Wellcome Trust [098051]; Royal Society [100087/Z/12/Z]; NHMRC of Australia [1061409, 1023526] FX SB is a Sir Henry Dale Fellow, jointly funded by the Wellcome Trust and the Royal Society (100087/Z/12/Z). NRT is supported by the Wellcome Trust grant #098051 to Wellcome Trust Sanger Institute. KEH is supported by fellowship #1061409 from the NHMRC of Australia. BPH is supported by fellowship #1023526 from the NHMRC of Australia. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 32 TC 2 Z9 2 U1 3 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1549-1676 J9 PLOS MED JI PLos Med. PD AUG PY 2016 VL 13 IS 8 AR e1002055 DI 10.1371/journal.pmed.1002055 PG 12 WC Medicine, General & Internal SC General & Internal Medicine GA DW0UD UT WOS:000383357400001 ER PT J AU Shatkin, JA Ong, KJ Beaudrie, C Clippinger, AJ Hendren, CO Haber, LT Hill, M Holden, P Kennedy, AJ Kim, B MacDonell, M Powers, CM Sharma, M Sheremeta, L Stone, V Sultan, Y Turley, A White, RH AF Shatkin, J. A. Ong, Kimberly J. Beaudrie, Christian Clippinger, Amy J. Hendren, Christine Ogilvie Haber, Lynne T. Hill, Myriam Holden, Patricia Kennedy, Alan J. Kim, Baram MacDonell, Margaret Powers, Christina M. Sharma, Monita Sheremeta, Lorraine Stone, Vicki Sultan, Yasir Turley, Audrey White, Ronald H. TI Advancing Risk Analysis for Nanoscale Materials: Report from an International Workshop on the Role of Alternative Testing Strategies for Advancement SO RISK ANALYSIS LA English DT Article DE Alternative testing strategies; expert workshop; nanomaterials; nanotoxicology; risk analysis ID ENGINEERED NANOMATERIALS; IN-VITRO; NANOPARTICLES; NANOTOXICOLOGY; TOXICITY; IDENTIFICATION; CYTOTOXICITY; ENVIRONMENT; PARTICLES; DOSIMETRY AB The Society for Risk Analysis (SRA) has a history of bringing thought leadership to topics of emerging risk. In September 2014, the SRA Emerging Nanoscale Materials Specialty Group convened an international workshop to examine the use of alternative testing strategies (ATS) for manufactured nanomaterials (NM) from a risk analysis perspective. Experts in NM environmental health and safety, human health, ecotoxicology, regulatory compliance, risk analysis, and ATS evaluated and discussed the state of the science for in vitro and other alternatives to traditional toxicology testing for NM. Based on this review, experts recommended immediate and near-term actions that would advance ATS use in NM risk assessment. Three focal areashuman health, ecological health, and exposure considerationsshaped deliberations about information needs, priorities, and the next steps required to increase confidence in and use of ATS in NM risk assessment. The deliberations revealed that ATS are now being used for screening, and that, in the near term, ATS could be developed for use in read-across or categorization decision making within certain regulatory frameworks. Participants recognized that leadership is required from within the scientific community to address basic challenges, including standardizing materials, protocols, techniques and reporting, and designing experiments relevant to real-world conditions, as well as coordination and sharing of large-scale collaborations and data. Experts agreed that it will be critical to include experimental parameters that can support the development of adverse outcome pathways. Numerous other insightful ideas for investment in ATS emerged throughout the discussions and are further highlighted in this article. C1 [Shatkin, J. A.; Ong, Kimberly J.] Vireo Advisors LLC, POB 51368, Boston, MA 02130 USA. [Beaudrie, Christian] Compass RM, Vancouver, CA USA. [Clippinger, Amy J.; Sharma, Monita] PETA Int Sci Consortium Ltd, London, England. [Hendren, Christine Ogilvie] Duke Univ, Ctr Environm Implicat NanoTechnol, Durham, NC USA. [Haber, Lynne T.] TERA, Cincinnati, OH USA. [Hill, Myriam] Hlth Canada, Ottawa, ON, Canada. [Holden, Patricia] Univ Calif Santa Barbara, Bren Sch Environm Sci & Management, ERI, Santa Barbara, CA 93106 USA. [Holden, Patricia] Univ Calif Santa Barbara, UC CEIN, Santa Barbara, CA 93106 USA. [Kennedy, Alan J.] US Army Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. [MacDonell, Margaret] Argonne Natl Lab, Div Environm Sci, 9700 S Cass Ave, Argonne, IL 60439 USA. [Powers, Christina M.] US EPA, Off Air & Radiat, Off Transportat & Air Qual, Ann Arbor, MI USA. [Sheremeta, Lorraine] Alberta Ingenu Labs, Edmonton, AB, Canada. [Stone, Vicki] Heriot Watt Univ, John Muir Bldg Gait 1, Edinburgh, Midlothian, Scotland. [Sultan, Yasir] Environm Canada, Gatineau, PQ, Canada. [Turley, Audrey] ICF Int, Durham, NC USA. [White, Ronald H.] RH White Consultants, Silver Spring, MD USA. RP Shatkin, JA (reprint author), Vireo Advisors LLC, POB 51368, Boston, MA 02130 USA. EM jashatkin@gmail.com FU National Science Foundation; Society for Risk Analysis Emerging Nanoscale Materials Specialty Group; Alberta Ingenuity Labs; PETA International Science Consortium Ltd.; Bergeson Campbell PC; American Chemistry Council; Keller and Heckman LLP; Toxicology Excellence in Risk Assessment FX The views expressed in this article are those of the authors and do not necessarily represent the views or policies or positions of their respective organizations. The authors wish to acknowledge the generous support of the following workshop co-sponsors: the National Science Foundation; the Society for Risk Analysis Emerging Nanoscale Materials Specialty Group; Alberta Ingenuity Labs; PETA International Science Consortium Ltd.; Bergeson & Campbell PC; American Chemistry Council; Keller and Heckman LLP; Toxicology Excellence in Risk Assessment; and in-kind contributions from: American Chemical Society, Center for the Environmental Implications of Nanotechnology; George Washington University Milken Institute for Public Health, Society for Toxicology Nanotoxicology Specialty Section; Society for Toxicology and Chemistry Nanotechnology Advisory Group; Sustainable Nanotechnology Organization; UC Center for the Environmental Implications of Nanotechnology; and U.S. Army Engineer Research and Development Center. The authors further wish to acknowledge the cooperation of the Organisation for Economic Cooperation and Development Working Party on Manufactured Nanomaterials. NR 60 TC 2 Z9 2 U1 7 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0272-4332 EI 1539-6924 J9 RISK ANAL JI Risk Anal. PD AUG PY 2016 VL 36 IS 8 SI SI BP 1520 EP 1537 DI 10.1111/risa.12683 PG 18 WC Public, Environmental & Occupational Health; Mathematics, Interdisciplinary Applications; Social Sciences, Mathematical Methods SC Public, Environmental & Occupational Health; Mathematics; Mathematical Methods In Social Sciences GA DW6OU UT WOS:000383771600004 PM 27510619 ER PT J AU Lanzi, JT Felix, J Tucker, CJ Cameron, KL Rogers, J Owens, BD Svoboda, SJ AF Lanzi, Joseph T., Jr. Felix, Justin Tucker, Christopher J. Cameron, Kenneth L. Rogers, John Owens, Brett D. Svoboda, Steven J. TI Comparison of the Suture Anchor and Transosseous Techniques for Patellar Tendon Repair: A Biomechanical Study SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE knee; patellar tendon; suture anchor; transosseous; gap; ultimate load; load to failure; rehabilitation; tensile test ID TOTAL KNEE ARTHROPLASTY; QUADRICEPS TENDON; CADAVER MODEL; GAP FORMATION; RUPTURES AB Background: Minimizing gap formation and maximizing the strength of patellar tendon repairs are 2 critical factors for successful healing of these injuries. Purpose/Hypothesis: The purpose of this study was to compare transosseous and screw-in anchor repair techniques to determine if there is a difference in gap formation and load to failure of the 2 constructs. The research hypotheses were that the anchor construct would have significantly less gap formation and would also have significantly greater load-to-failure strength. Study Design: Controlled laboratory study. Methods: A total of 24 porcine specimens were randomly assigned into transosseous and 4.75-mm polyetheretherketone (PEEK) screw-in anchor repair groups. The repairs were then completed using 2 No. 2 FiberWire sutures, and each specimen was cyclically loaded on a tensile test machine to 250 N for a total of 1000 cycles. Gap formation was measured at 1, 10, 250, 500, and 1000 cycles. Each specimen was loaded to failure after 1000 cycles. Independent t tests were conducted. Results: Statistically significant gap formation and load-to-failure differences were found between the 2 repair techniques. The mean gap in the anchor group (2.16 1.81 mm) was significantly less than that seen in the transosseous group (5.71 1.58 mm) (P < .001). The mean load to failure of the anchor group (669.9 +/- 91.8 N) was significantly higher than that of the transosseous group (582.8 +/- 92.6 N) (P = .03). Conclusion: The results support the 2 study hypotheses. These findings suggest that the 4.75-mm PEEK screw-in anchor construct may be superior to the transosseous technique for minimizing gap formation and improving load-to-failure strength after surgical repair of the patellar tendon. Clinical Relevance: The use of the suture anchor technique in patellar tendon repair may support early load-bearing rehabilitation. C1 [Lanzi, Joseph T., Jr.; Felix, Justin; Tucker, Christopher J.; Cameron, Kenneth L.; Rogers, John; Owens, Brett D.; Svoboda, Steven J.] US Mil Acad, West Point, NY 10996 USA. [Lanzi, Joseph T., Jr.; Tucker, Christopher J.; Cameron, Kenneth L.; Owens, Brett D.; Svoboda, Steven J.] US Mil Acad, Keller Army Hosp, West Point, NY 10996 USA. [Felix, Justin; Rogers, John] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. RP Lanzi, JT (reprint author), William Beaumont Army Med Ctr, Dept Orthopaed Surg & Rehabil, 5005 North Piedras St, El Paso, TX 79920 USA. EM joseph.t.lanzi.mil@mail.mil FU Cayenne; Mitek; MTF FX Arthrex donated equipment and implants for use in this study. J.T.L. receives royalties/consulting fees from Cayenne and owns stock in Stryker. B.D.O. receives royalties/consulting fees from Mitek and MTF. NR 25 TC 0 Z9 0 U1 1 U2 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 EI 1552-3365 J9 AM J SPORT MED JI Am. J. Sports Med. PD AUG PY 2016 VL 44 IS 8 BP 2076 EP 2080 DI 10.1177/0363546516643811 PG 5 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA DU4UM UT WOS:000382208100023 PM 27179054 ER PT J AU Oh, JS Lawson, A Walsh, N Strode, M Burgess, P Ramirez, M AF Oh, Jin Sol Lawson, Andrew Walsh, Nathaniel Strode, Matthew Burgess, Pamela Ramirez, Manuel TI Symptomatic Late Saphenous Vein Graft Aneurysm in an Upper Extremity Bypass SO AMERICAN SURGEON LA English DT Article; Proceedings Paper CT Annual Scientific Meeting of the Southeastern-Surgical-Congress (SESC) CY FEB 05-26, 2016 CL Atlanta, GA SP SE Surg Congress C1 [Oh, Jin Sol; Lawson, Andrew; Walsh, Nathaniel] Augusta Univ, Med Coll Georgia, Dept Surg, 1120 15th St BI 4070, Augusta, GA 30912 USA. [Strode, Matthew; Burgess, Pamela] Eisenhower Med Ctr, Dept Surg, Ft Gordon, GA USA. [Ramirez, Manuel] Charlie Norwood VA Hosp, Dept Surg, Augusta, GA USA. RP Oh, JS (reprint author), Augusta Univ, Med Coll Georgia, Dept Surg, 1120 15th St BI 4070, Augusta, GA 30912 USA. EM joh@gru.edu NR 4 TC 0 Z9 0 U1 0 U2 0 PU SOUTHEASTERN SURGICAL CONGRESS PI CUMMING PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA SN 0003-1348 EI 1555-9823 J9 AM SURGEON JI Am. Surg. PD AUG PY 2016 VL 82 IS 8 BP E214 EP E216 PG 3 WC Surgery SC Surgery GA DV9NZ UT WOS:000383269200016 ER PT J AU DeGregorio, BA Chiavacci, SJ Benson, TJ Sperry, JH Weatherhead, PJ AF DeGregorio, Brett A. Chiavacci, Scott J. Benson, Thomas J. Sperry, Jinelle H. Weatherhead, Patrick J. TI Nest Predators of North American Birds: Continental Patterns and Implications SO BIOSCIENCE LA English DT Article DE avian ecology; breeding behavior; nest cameras; predator-prey interactions; predator identity ID ELAPHE-OBSOLETA; SITE SELECTION; SONGBIRD NESTS; HABITAT USE; REPRODUCTIVE SUCCESS; VIDEO CAMERAS; POINT COUNTS; FOREST-EDGE; RISK; SNAKES AB Identifying nest predators is of fundamental importance to understanding avian breeding ecology and can contribute to identifying broadscale nest-predation patterns. We reviewed 53 North American nest-predator studies, comprising more than 4000 camera-monitored nests, to explore geographic patterns in predator identity and how predation varied with predator richness, habitat, nest height, and bird size. Overall, mesopredators (at high latitudes) and snakes (at low latitudes) were the most frequent nest-predator guilds. Predation by rodents was greatest in the Great Plains and boreal forest and by corvids in the Southwest. Predation by different guilds was often correlated. Predator richness was greatest at midlatitudes but was a poor predictor of predation probability. Nest height and habitat influenced predator-specific predation. The richness of predator species was not influenced by bird body size, nesting height, or habitat type. Our results enable the prediction of regionally influential predators, highlight knowledge gaps, and provide a foundation for further exploration. C1 [DeGregorio, Brett A.; Chiavacci, Scott J.; Benson, Thomas J.; Sperry, Jinelle H.; Weatherhead, Patrick J.] Univ Illinois, Dept Nat Resources & Environm Sci, Champaign, IL 61820 USA. [Sperry, Jinelle H.] Engineer Res & Dev Ctr, Champaign, IL USA. [Chiavacci, Scott J.; Benson, Thomas J.] Univ Illinois, Illinois Nat Hist Survey, Prairie Res Inst, Champaign, IL 61820 USA. RP DeGregorio, BA (reprint author), Univ Illinois, Dept Nat Resources & Environm Sci, Champaign, IL 61820 USA. EM badegregorio@gmail.com FU Construction Engineering Research Laboratory of the Engineer Research Development Center; Illinois Department of Natural Resources; US Fish and Wildlife Service via the Federal Aid in Wildlife Restoration Program [W-161-R]; Kane County Forest Preserve District; Lake Cook Audubon; ERDC FX Funding for the preparation of this manuscript was provided by the Construction Engineering Research Laboratory of the Engineer Research Development Center. Funding for work in Illinois was provided by the Illinois Department of Natural Resources and the US Fish and Wildlife Service via the Federal Aid in Wildlife Restoration Program (project no. W-161-R), Kane County Forest Preserve District, and Lake Cook Audubon. We thank Tim Hayden for arranging funding through the ERDC. We wish to thank the three reviewers who provided insightful feedback and improved this manuscript. We also wish to thank all the authors who generously shared unreported data with us to facilitate this review. Animal procedures conformed to permits approved by the University of Illinois (IACUC no. 11054 and no. 10127). NR 59 TC 0 Z9 0 U1 19 U2 19 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0006-3568 EI 1525-3244 J9 BIOSCIENCE JI Bioscience PD AUG PY 2016 VL 66 IS 8 BP 655 EP 665 DI 10.1093/biosci/biw071 PG 11 WC Biology SC Life Sciences & Biomedicine - Other Topics GA DV8LG UT WOS:000383187900005 ER PT J AU Fries, CA Lawson, SD Gorantla, VS Rickard, RF Davis, MR AF Fries, C. A. Lawson, S. D. Gorantla, V. S. Rickard, R. F. Davis, M. R. TI Enzyme Triggered Drug Delivery for Graft Targeted Immunosuppression and Neuroregeneration after VCA SO BRITISH JOURNAL OF SURGERY LA English DT Meeting Abstract CT International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland CY 2016 CL Belfast, IRELAND SP Assoc Surg Great Britain & Ireland C1 [Fries, C. A.; Lawson, S. D.; Davis, M. R.] US Army Inst Surg Res, San Antonio, TX USA. [Rickard, R. F.] Royal Ctr Def Med, Birmingham, W Midlands, England. [Gorantla, V. S.] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0007-1323 EI 1365-2168 J9 BRIT J SURG JI Br. J. Surg. PD AUG PY 2016 VL 103 SU 6 SI SI MA 0475 BP 90 EP 90 PG 1 WC Surgery SC Surgery GA DV9VF UT WOS:000383289600283 ER PT J AU Cindass, R Wu, KY Lawson, SD Gorantla, VS Davis, MR AF Cindass, Renford, Jr. Wu, Kevin Y. Lawson, Sharon D. Gorantla, Vijay S. Davis, Michael R. TI A Novel Bioresorbable/Biointegratable/Biocompatible Dressing for Negative Pressure Wound Therapy SO BRITISH JOURNAL OF SURGERY LA English DT Meeting Abstract CT International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland CY 2016 CL Belfast, IRELAND SP Assoc Surg Great Britain & Ireland C1 [Cindass, Renford, Jr.; Wu, Kevin Y.; Lawson, Sharon D.; Davis, Michael R.] RESTORTM Program, Afb, TX USA. [Cindass, Renford, Jr.] San Antonio Mil Med Ctr, Jbsa Ft Sam Houston, TX USA. [Lawson, Sharon D.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Gorantla, Vijay S.] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA. [Davis, Michael R.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0007-1323 EI 1365-2168 J9 BRIT J SURG JI Br. J. Surg. PD AUG PY 2016 VL 103 SU 6 SI SI MA E033 BP 91 EP 91 PG 1 WC Surgery SC Surgery GA DV9VF UT WOS:000383289600288 ER PT J AU Lawson, SD Wang, LC Cindass, R Wu, K Davis, MR AF Lawson, S. D. Wang, L. C. Cindass, R. Wu, K. Davis, M. R. TI Hyperbaric normothermic perfusion mitigates reperfusion injury in porcine VCA SO BRITISH JOURNAL OF SURGERY LA English DT Meeting Abstract CT International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland CY 2016 CL Belfast, IRELAND SP Assoc Surg Great Britain & Ireland C1 [Lawson, S. D.; Wu, K.; Davis, M. R.] San Antonio Mil Med Ctr, US Army Inst Surg Res, San Antonio, TX USA. [Wang, L. C.; Cindass, R.] San Antonio Mil Med Ctr, Dept Gen Surg, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0007-1323 EI 1365-2168 J9 BRIT J SURG JI Br. J. Surg. PD AUG PY 2016 VL 103 SU 6 SI SI MA E011 BP 91 EP 92 PG 2 WC Surgery SC Surgery GA DV9VF UT WOS:000383289600289 ER PT J AU Wong, KK Davey, RT Hewlett, AL Kraft, CS Mehta, AK Mulligan, MJ Beck, A Dorman, W Kratochvil, CJ Lai, LL Palmore, TN Rogers, S Smith, P Suffredini, AF Wolcott, M Stroher, U Uyeki, TM AF Wong, Karen K. Davey, Richard T., Jr. Hewlett, Angela L. Kraft, Colleen S. Mehta, Aneesh K. Mulligan, Mark J. Beck, Allison Dorman, William Kratochvil, Christopher J. Lai, Lilin Palmore, Tara N. Rogers, Susan Smith, PhilipW. Suffredini, Anthony F. Wolcott, Mark Stroher, Ute Uyeki, Timothy M. TI Use of Postexposure Prophylaxis After Occupational Exposure to Zaire ebolavirus SO CLINICAL INFECTIOUS DISEASES LA English DT Article DE Ebola virus; postexposure prophylaxis; vesicular stomatitis virus; TKM-Ebola ID VIRUS DISEASE; UNITED-STATES; VACCINATION; MANAGEMENT AB From September 2014 to April 2015, 6 persons who had occupational exposures to Zaire ebolavirus in West Africa received investigational agent rVSV-ZEBOV or TKM-100802 for postexposure prophylaxis and were monitored in the United States. All patients experienced self-limited symptoms after postexposure prophylaxis; none developed Ebola virus disease. C1 [Wong, Karen K.; Stroher, Ute; Uyeki, Timothy M.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Kraft, Colleen S.; Mehta, Aneesh K.; Mulligan, Mark J.; Beck, Allison; Lai, Lilin; Rogers, Susan] Emory Univ, Atlanta, GA 30322 USA. [Davey, Richard T., Jr.; Palmore, Tara N.] NIAID, 9000 Rockville Pike, Bethesda, MD 20892 USA. [Suffredini, Anthony F.] NIH, Crit Care Med Dept, Ctr Clin, Bldg 10, Bethesda, MD 20892 USA. [Dorman, William; Wolcott, Mark] US Army, Med Res Inst Infect Dis, Frederick, MD USA. [Hewlett, Angela L.; Kratochvil, Christopher J.; Smith, PhilipW.] Univ Nebraska Med Ctr, Omaha, NE USA. RP Wong, KK (reprint author), 1600 Clifton Rd NE,MS C-09, Atlanta, GA 30329 USA. EM kwong@cdc.gov FU CDC; National Center for Advancing Translational Sciences of the NIH [UL1TR000454]; NIAID FX This work was supported by the CDC. The care of patients at the Emory Serious Communicable Diseases Unit was supported in part by the National Center for Advancing Translational Sciences of the NIH (award UL1TR000454). The care of patients at the NIH Clinical Center was funded by the NIAID. NR 15 TC 2 Z9 2 U1 1 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD AUG 1 PY 2016 VL 63 IS 3 BP 376 EP 379 DI 10.1093/cid/ciw256 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA DV8QP UT WOS:000383201900013 PM 27118786 ER PT J AU Clayton, JD AF Clayton, J. D. TI Dimensional analysis and extended hydrodynamic theory applied to long-rod penetration of ceramics SO DEFENCE TECHNOLOGY LA English DT Article DE Ceramics; Terminal ballistics; Armor; Dimensional analysis; Hydrodynamics ID HIGH-STRAIN RATE; ALUMINUM NITRIDE; BORON-CARBIDE; NONLINEAR ELASTICITY; BRITTLE MATERIALS; SILICON-CARBIDE; HIGH-VELOCITY; TARGETS; MODEL; IMPACT AB Principles of dimensional analysis are applied in a new interpretation of penetration of ceramic targets subjected to hypervelocity impact. The analysis results in a power series representation - in terms of inverse velocity - of normalized depth of penetration that reduces to the hydrodynamic solution at high impact velocities. Specifically considered are test data from four literature sources involving penetration of confined thick ceramic targets by tungsten long rod projectiles. The ceramics are AD-995 alumina, aluminum nitride, silicon carbide, and boron carbide. Test data can be accurately represented by the linear form of the power series, whereby the same value of a single fitting parameter applies remarkably well for all four ceramics. Comparison of the present model with others in the literature (e.g., Tate's theory) demonstrates a target resistance stress that depends on impact velocity, linearly in the limiting case. Comparison of the present analysis with recent research involving penetration of thin ceramic tiles at lower typical impact velocities confirms the importance of target properties related to fracture and shear strength at the Hugoniot Elastic Limit (HEL) only in the latter. In contrast, in the former (i.e., hypervelocity and thick target) experiments, the current analysis demonstrates dominant dependence of penetration depth only by target mass density. Such comparisons suggest transitions from microstructure-controlled to density-controlled penetration resistance with increasing impact velocity and ceramic target thickness. Production and hosting by Elsevier B.V. on behalf of China Ordnance Society. C1 [Clayton, J. D.] US Army Res Lab, Impact Phys RDRL WMP C, Aberdeen Proving Ground, MD 21005 USA. [Clayton, J. D.] Univ Maryland, A James Clark Sch Engn, College Pk, MD 20742 USA. RP Clayton, JD (reprint author), US Army Res Lab, Impact Phys RDRL WMP C, Aberdeen Proving Ground, MD 21005 USA.; Clayton, JD (reprint author), Univ Maryland, A James Clark Sch Engn, College Pk, MD 20742 USA. EM john.d.clayton1.civ@mail.mil NR 71 TC 0 Z9 0 U1 2 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 2214-9147 J9 DEF TECHNOL JI Def. Technol. PD AUG PY 2016 VL 12 IS 4 BP 334 EP 342 DI 10.1016/j.dt.2016.02.004 PG 9 WC Engineering, Multidisciplinary SC Engineering GA DV8NX UT WOS:000383194800007 ER PT J AU Deeks, SG Lewin, SR Ross, AL Ananworanich, J Benkirane, M Cannon, P Chomont, N Douek, D Lifson, JD Lo, YR Kuritzkes, D Margolis, D Mellors, J Persaud, D Tucker, JD Barre-Sinoussi, F Alter, G Auerbach, J Autran, B Barouch, DH Behrens, G Cavazzana, M Chen, ZW Cohen, EA Corbelli, GM Eholie, S Eyal, N Fidler, S Garcia, L Grossman, C Henderson, G Henrich, TJ Jefferys, R Kiem, HP McCune, J Moodley, K Newman, PA Nijhuis, M Nsubuga, MS Ott, M Palmer, S Richman, D Saez-Cirion, A Sharp, M Siliciano, J Silvestri, G Singh, J Spire, B Taylor, J Tolstrup, M Valente, S van Lunzen, J Walensky, R Wilson, I Zack, J AF Deeks, Steven G. Lewin, Sharon R. Ross, Anna Laura Ananworanich, Jintanat Benkirane, Monsef Cannon, Paula Chomont, Nicolas Douek, Daniel Lifson, Jeffrey D. Lo, Ying-Ru Kuritzkes, Daniel Margolis, David Mellors, John Persaud, Deborah Tucker, Joseph D. Barre-Sinoussi, Francoise Alter, Galit Auerbach, Judith Autran, Brigitte Barouch, Dan H. Behrens, Georg Cavazzana, Marina Chen, Zhiwei Cohen, Eric A. Corbelli, Giulio Maria Eholie, Serge Eyal, Nir Fidler, Sarah Garcia, Laurindo Grossman, Cynthia Henderson, Gail Henrich, Timothy J. Jefferys, Richard Kiem, Hans-Peter McCune, Joseph Moodley, Keymanthri Newman, Peter A. Nijhuis, Monique Nsubuga, Moses Supercharger Ott, Melanie Palmer, Sarah Richman, Douglas Saez-Cirion, Asier Sharp, Matthew Siliciano, Janet Silvestri, Guido Singh, Jerome Spire, Bruno Taylor, Jeffrey Tolstrup, Martin Valente, Susana van Lunzen, Jan Walensky, Rochelle Wilson, Ira Zack, Jerome CA Int AIDS Soc Cure Working Grp TI International AIDS Society global scientific strategy: towards an HIV cure 2016 SO NATURE MEDICINE LA English DT Article ID CD4(+) T-CELLS; SUPPRESSIVE ANTIRETROVIRAL THERAPY; BROADLY NEUTRALIZING ANTIBODIES; HISTONE DEACETYLASE INHIBITOR; HIGHLY PATHOGENIC SIV; LATENT HIV-1; VIRAL RESERVOIR; IN-VIVO; TREATMENT INTERRUPTION; RALTEGRAVIR INTENSIFICATION AB Antiretroviral therapy is not curative. Given the challenges in providing lifelong therapy to a global population of more than 35 million people living with HIV, there is intense interest in developing a cure for HIV infection. The International AIDS Society convened a group of international experts to develop a scientific strategy for research towards an HIV cure. This Perspective summarizes the group's strategy. C1 [Deeks, Steven G.; Auerbach, Judith; Henrich, Timothy J.; McCune, Joseph] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA. [Lewin, Sharon R.] Univ Melbourne, Peter Doherty Inst Infect & Immun, Melbourne, Vic, Australia. [Lewin, Sharon R.] Royal Melbourne Hosp, Melbourne, Vic, Australia. [Lewin, Sharon R.] Alfred Hosp, Dept Infect Dis, Melbourne, Vic, Australia. [Lewin, Sharon R.] Monash Univ, Melbourne, Vic, Australia. [Ross, Anna Laura] ANRS, Int & Sci Relat Off, Paris, France. [Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD 20817 USA. [Benkirane, Monsef] Univ Montpellier, CNRS UPR 1142, Inst Human Genet, Mol Virol Lab, Montpellier, France. [Cannon, Paula] Univ Southern Calif, Keck Sch Med, Los Angeles, CA 90033 USA. [Chomont, Nicolas] Univ Montreal, Fac Med, CRCHUM, Montreal, PQ, Canada. [Chomont, Nicolas] Univ Montreal, Fac Med, Dept Microbiol Infectiol & Immunol, Montreal, PQ, Canada. [Douek, Daniel] NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. [Lifson, Jeffrey D.] Leidos Biomed Res Inc, AIDS & Canc Virus Program, Frederick Natl Lab, Frederick, MD 21702 USA. [Lo, Ying-Ru] World Hlth Org Reg Off Western Pacific, Manila, Philippines. [Kuritzkes, Daniel; Henrich, Timothy J.] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA. [Margolis, David; Henderson, Gail] Univ N Carolina, Sch Med, Chapel Hill, NC 27599 USA. [Mellors, John] Univ Pittsburgh, Dept Med, Div Infect Dis, 930 Scaife Hall, Pittsburgh, PA 15260 USA. [Persaud, Deborah] Johns Hopkins Univ, Sch Med, Baltimore, MD 21205 USA. [Persaud, Deborah] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA. [Tucker, Joseph D.] Univ North Carolina Project China, Guangzhou, Guangdong, Peoples R China. [Barre-Sinoussi, Francoise] Inst Pasteur, Paris, France. [Alter, Galit; Barouch, Dan H.] MIT & Harvard, Ragon Inst MGH, Boston, MA USA. [Autran, Brigitte] Univ Paris 06, Sorbonne Univ, CIMI, Paris, France. [Autran, Brigitte] CIMI Paris, INSERM, U1135, Paris, France. [Autran, Brigitte] Hop La Pitie Salpetriere, AP HP, Dept Immunol, Paris, France. [Barouch, Dan H.] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA. [Behrens, Georg] Hannover Med Sch, Clin Immunol & Rhematol, Hannover, Germany. [Cavazzana, Marina] Hop Necker Enfants Malad, Ctr Invest Clin Biotherapie, Paris, France. [Chen, Zhiwei] Univ Hong Kong, AIDS Inst, Pok Fu Lam, Hong Kong, Peoples R China. [Cohen, Eric A.] Univ Montreal, Inst Rech Clin Montreal, Montreal, PQ, Canada. [Corbelli, Giulio Maria] European AIDS Treatment Grp, Rome, Italy. [Eholie, Serge] Ctr Hosp Univ Treichville, Programme PAC CI, Abidjan, Cote Ivoire. [Eyal, Nir] Harvard TH Chan Sch Publ Hlth, Dept Global Hlth & Populat, Boston, MA USA. [Fidler, Sarah] Imperial Coll London, Dept Med, London, England. [Garcia, Laurindo] B Change Grp, Manila, Philippines. [Grossman, Cynthia] NIMH, NIH, Bethesda, MD 20892 USA. [Jefferys, Richard] Treatment Act Grp, New York, NY 10016 USA. [Kiem, Hans-Peter] Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA. [Moodley, Keymanthri] Univ Stellenbosch, Dept Med, Ctr Med Eth & Law, Western Cape, South Africa. [Newman, Peter A.] Univ Toronto, Factor Inwentash Fac Social Work, Toronto, ON, Canada. [Nijhuis, Monique] Univ Med Ctr Utrecht, Dept Med Microbiol, Virol, Utrecht, Netherlands. [Nsubuga, Moses Supercharger] Joint Clin Res Ctr, Kampala, Uganda. [Ott, Melanie] Univ Calif San Francisco, Gladstone Inst, San Francisco, CA 94143 USA. [Palmer, Sarah] Univ Sydney, Westmead Millennium Inst Med Res, Sydney, NSW, Australia. [Richman, Douglas] Virginia San Diego Healthcare Syst, San Diego, CA 92161 USA. [Richman, Douglas] Univ Calif San Diego, San Diego, CA 92103 USA. [Saez-Cirion, Asier] Inst Pasteur, Paris, France. [Sharp, Matthew] Independent HIV Educ & Advocacy Consultant, San Francisco, CA USA. [Siliciano, Janet] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA. [Silvestri, Guido] Emory Univ, Yerkes Natl Primate Res Ctr, Atlanta, GA 30322 USA. [Singh, Jerome] Univ KwaZulu Natal, Nelson R Mandela Sch Med, Durban, South Africa. [Spire, Bruno] INSERM, UMR S912, Marseille, France. [Taylor, Jeffrey] CARE Collaboratory Community Advisory Board, Palm Springs, CA USA. [Tolstrup, Martin] Aarhus Univ, Inst Clin Med, Aarhus, Denmark. [Valente, Susana] Scripps Res Inst, Dept Immunol & Microbial Sci, Jupiter, FL 33458 USA. [van Lunzen, Jan] ViiV Healthcare, London, England. [Walensky, Rochelle] Harvard Med Sch, Massachusetts Gen Hosp, Boston, MA 02115 USA. [Wilson, Ira] Brown Univ, Sch Publ Hlth, Dept Hlth Serv Policy & Practice, Providence, RI 02912 USA. [Zack, Jerome] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA. RP Deeks, SG (reprint author), Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA. EM steven.deeks@ucsf.edu RI Behrens, Georg/Q-4486-2016; Spire, Bruno/F-5546-2013; OI Spire, Bruno/0000-0002-3546-8020; Deeks, Steven/0000-0001-6371-747X; Saez-Cirion, Asier/0000-0003-2406-7536; Lewin, Sharon Ruth/0000-0002-0330-8241 FU federal funds from the NCI/NIH [HHSN261200800001E] FX J.L. is supported in part by federal funds from the NCI/NIH under contract no. HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the DHHS, nor does mention of trade names, commercial products or organizations imply endorsement by the U.S. government. The views expressed are those of the authors and should not be construed to represent the positions of the U.S. Army, the Department of Defense or the US National Institutes of Health. Y.-R.L. is a World Health Organization (WHO) staff member. The opinions herein are those of the authors and should not be construed as official or representing the views of the WHO. The authors acknowledge T. Rasmussen, T. Mota and M. Crane for assistance with preparation of figures. NR 125 TC 10 Z9 10 U1 18 U2 18 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1078-8956 EI 1546-170X J9 NAT MED JI Nat. Med. PD AUG PY 2016 VL 22 IS 8 BP 839 EP 850 DI 10.1038/nm.4108 PG 12 WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental Medicine GA DS7YV UT WOS:000381000200009 PM 27400264 ER PT J AU DaCosta, RS Ottolino-Perry, K Banerjee, J AF DaCosta, Ralph S. Ottolino-Perry, Kathryn Banerjee, Jaideep TI Can Imaging Put the "Advanced" Back in Advanced Wound Care? SO ADVANCES IN WOUND CARE LA English DT Editorial Material AB An effective, scientifically validated, diagnostic tool helps clinicians make better, timely, and more objective medical decisions in the care of their patients. Today, the need for such tools is especially urgent in the field of wound care where patient-centric care is the goal, under ever tightening clinical budget constraints. In an era of countless "innovative" treatment options, that is, advanced dressings, negative pressure devices, and various debridement instruments available to the wound care clinical team, one area that has arguably languished in the past decade has been innovation in wound diagnostics. Whereas medical imaging is a mainstay in the diagnostic toolkit across many other medical fields (oncology, neurology, gastroenterology, orthopedics, etc.), the field of wound care has yet to realize the full potential that advances in imaging technologies have to offer the clinician. In this issue, the first of a series in wound imaging and diagnostics, four articles have been assembled, highlighting some of the recent advances in wound imaging technologies. C1 [DaCosta, Ralph S.; Ottolino-Perry, Kathryn] Univ Hlth Network, Princess Margaret Canc Ctr, 101 Coll St,Princess Margaret Canc Res Tower, Toronto, ON M5G 1L7, Canada. [DaCosta, Ralph S.] Univ Hlth Network, Techna Inst, Toronto, ON, Canada. [DaCosta, Ralph S.] Univ Toronto, Fac Med, Dept Med Biophys, Toronto, ON, Canada. [DaCosta, Ralph S.] MolecuLight Inc, Toronto, ON, Canada. [Banerjee, Jaideep] US Army Inst Surg Res, Ft Sam Houston, TX USA. RP DaCosta, RS (reprint author), Univ Hlth Network, Princess Margaret Canc Ctr, 101 Coll St,Princess Margaret Canc Res Tower, Toronto, ON M5G 1L7, Canada. EM rdacosta@uhnres.utoronto.ca NR 3 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 2162-1918 EI 2162-1934 J9 ADV WOUND CARE JI Adv. Wound Care PD AUG PY 2016 VL 5 IS 8 BP 329 EP 331 DI 10.1089/wound.2016.0702 PG 3 WC Dermatology SC Dermatology GA DV0SC UT WOS:000382628300001 ER PT J AU Patel, RB Stepanov, V Qiu, HW AF Patel, Rajen B. Stepanov, Victor Qiu, Hongwei TI Dependence of Raman Spectral Intensity on Crystal Size in Organic Nano Energetics SO APPLIED SPECTROSCOPY LA English DT Article DE Raman spectroscopy; crystal size; nanoenergetics; nanomaterial; RDX; HMX; TATB; CL-20; explosive; surface disorder ID PARTICLE-SIZE; IN-LINE; ICE; SPECTROSCOPY; SILICON; SURFACE; IMPACT; NANOPARTICLES; EXPLOSIVES; SCATTERING AB Raman spectra for various nitramine energetic compounds were investigated as a function of crystal size at the nanoscale regime. In the case of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20), there was a linear relationship between intensity of Raman spectra and crystal size. Notably, the Raman modes between 120cm(-1) and 220cm(-1) were especially affected, and at the smallest crystal size, were completely eliminated. The Raman spectral intensity of octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX), like that of CL-20's, depended linearly on crystal size. The Raman spectral intensity of 1,3,5-trinitroperhydro-1,3,5-triazine (RDX), however, was not observably changed by crystal size. A non-nitramine explosive compound, 2,4,6-triamino-1,3,5- trinitrobenzene (TATB), was also investigated. Its spectral intensity was also found to correlate linearly with crystal size, although substantially less so than that of HMX and CL-20. To explain the observed trends, it is hypothesized that disordered molecular arrangement, originating from the crystal surface, may be responsible. In particular, it appears that the thickness of the disordered surface layer is dependent on molecular characteristics, including size and conformational flexibility. Furthermore, as the mean crystal size decreases, the volume fraction of disordered molecules within a specimen increases, consequently, weakening the Raman intensity. These results could have practical benefit for allowing the facile monitoring of crystal size during manufacturing. Finally, these findings could lead to deep insights into the general structure of the surface of crystals. C1 [Patel, Rajen B.; Stepanov, Victor] US Army, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ USA. [Qiu, Hongwei] Leidos Inc, Engn & Technol Solut Div, Picatinny Arsenal, NJ USA. RP Patel, RB (reprint author), US Army, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ USA. EM rajen.b.patel.civ@mail.mil FU U.S. Army at Picatinny Arsenal FX This work was performed under the auspices of the U.S. Army at Picatinny Arsenal. The authors would like to thank the following individuals for providing constructive comments on the paper: Zafar Iqbal, Frank Owens, Brian Disalle, and Alex Paraskos. The authors would like to also thank Ashok Surapaneni for programmatic support and Mouhcine Doukkali for assistance in making and analyzing the TATB. NR 38 TC 0 Z9 0 U1 5 U2 5 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0003-7028 EI 1943-3530 J9 APPL SPECTROSC JI Appl. Spectrosc. PD AUG PY 2016 VL 70 IS 8 BP 1339 EP 1345 DI 10.1177/0003702816654077 PG 7 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA DU9MC UT WOS:000382540500008 PM 27449371 ER PT J AU Ranz, EC Esposito, ER Wilken, JM Neptune, RR AF Ranz, Ellyn C. Esposito, Elizabeth Russell Wilken, Jason M. Neptune, Richard R. TI The influence of passive-dynamic ankle-foot orthosis bending axis location on gait performance in individuals with lower-limb impairments SO CLINICAL BIOMECHANICS LA English DT Article DE PD-AFOs; Limb salvage; Selective laser sintering; Gait; Biomechanics ID JOINT COORDINATE SYSTEM; WALKING; STIFFNESS; PROGRESSION; HEMIPLEGIA; FRAMEWORK; ALIGNMENT; ROTATION; CHILDREN; AMPUTEES AB Background: Passive-dynamic ankle-foot orthoses are commonly prescribed to augment impaired ankle muscle function, however their design and prescription are largely qualitative. One design includes a footplate and cuff, and flexible strut connecting the two. During gait, deflection occurs along the strut, with the greatest deflection at a central bending axis. The vertical location of the axis can affect lower extremity biomechanics. The goal of this study was to investigate the influence of bending axis location on gait performance. Methods: For thirteen participants with unilateral ankle muscle weakness, an additive manufacturing framework was used to fabricate passive-dynamic ankle-foot orthosis struts with central and off-center bending axes. Participants walked overground while electromyographic, kinetic and kinematic data were collected for three different bending axes: proximal (high), central (middle) and distal (low), and the participants indicated their order of bending axis preference after testing. Gait measures and preference effect sizes were examined during six regions of the gait cycle. Findings: A few differences between bending axes were observed: in the first double-leg support peak plantarflexion angle, peak dorsiflexion moment and positive hip work, in the early single-leg support peak knee extension moment and positive ankle and knee work, and in the late single-leg support gastrocnemius activity and vertical ground reaction force impulse. In addition, preference was strongly related to various gait measures. Interpretation: Despite the observed statistical differences, altering bending axis location did not produce large and consistent changes in gait performance. Thus, individual preference and comfort may be more important factors guiding prescription. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Ranz, Ellyn C.; Neptune, Richard R.] Univ Texas Austin, Dept Mech Engn, 204 E Dean Keeton St,Stop C2200, Austin, TX 78712 USA. [Esposito, Elizabeth Russell; Wilken, Jason M.] Brooke Army Med Ctr, Ctr Intrepid, JBSA, Ft Sam Houston, TX 78234 USA. [Esposito, Elizabeth Russell; Wilken, Jason M.] Extrem Trauma & Amputat Ctr Excellence, Ft Sam Houston, TX USA. RP Neptune, RR (reprint author), Univ Texas Austin, Dept Mech Engn, 204 E Dean Keeton St,Stop C2200, Austin, TX 78712 USA. EM rneptune@mail.utexas.edu FU Center for Rehabilitation Sciences Research (CRSR); Department of Physical Medicine and Rehabilitation, Uniformed Services University of Health Sciences, Bethesda, MD FX The authors would like to thank the members of the Military Performance Laboratory at the Center for the Intrepid for their contributions to this study in participant recruitment, experimental data collection and data processing. This study was supported in part by a research grant from the Center for Rehabilitation Sciences Research (CRSR), Department of Physical Medicine and Rehabilitation, Uniformed Services University of Health Sciences, Bethesda, MD. The views expressed herein are those of the authors and do not reflect the official policy or position of Brooke Army Medical Center, the U.S. Army Medical Department, the U.S. Army Office of the Surgeon General, the Department of the Army, Department of Defense or the U.S. Government. NR 38 TC 1 Z9 1 U1 11 U2 11 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0268-0033 EI 1879-1271 J9 CLIN BIOMECH JI Clin. Biomech. PD AUG PY 2016 VL 37 BP 13 EP 21 DI 10.1016/j.clinbiomech.2016.05.001 PG 9 WC Engineering, Biomedical; Orthopedics; Sport Sciences SC Engineering; Orthopedics; Sport Sciences GA DV3CL UT WOS:000382798500003 PM 27280325 ER PT J AU Li, N Georas, S Alexis, N Fritz, P Xia, T Williams, MA Horner, E Nel, A AF Li, Ning Georas, Steve Alexis, Neil Fritz, Patricia Xia, Tian Williams, Marc A. Horner, Elliott Nel, Andre TI A work group report on ultrafine particles (American Academy of Allergy, Asthma & Immunology): Why ambient ultrafine and engineered nanoparticles should receive special attention for possible adverse health outcomes in human subjects SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Article DE Ambient ultrafine particles; engineered nanoparticles; particle deposition and distribution; allergic inflammation; asthma; lung inflammation; oxidative stress; effect on human health ID PREDICTIVE TOXICOLOGICAL APPROACH; WALLED CARBON NANOTUBES; PARTICULATE MATTER; OXIDATIVE STRESS; AIR-POLLUTION; ZINC-OXIDE; LUNG INFLAMMATION; PULMONARY INFLAMMATION; EXPOSURE IMPLICATIONS; SILVER NANOPARTICLES AB Ultrafine particles (UFPs) are airborne particulates of less than 100 nm in aerodynamic diameter. Examples of UFPs are diesel exhaust particles, products of cooking, heating, and wood burning in indoor environments, and, more recently, products generated through the use of nanotechnology. Studies have shown that ambient UFPs have detrimental effects on both the cardiovascular and respiratory systems, including a higher incidence of atherosclerosis and exacerbation rate of asthma. UFPs have been found to alter in vitro and in vivo responses of the immune system to allergens and can also play a role in allergen sensitization. The inflammatory properties of UFPs can be mediated by a number of different mechanisms, including the ability to produce reactive oxygen species, leading to the generation of proinflammatory cytokines and airway inflammation. In addition, because of their small size, UFPs also have unique distribution characteristics in the respiratory tree and circulation and might be able to alter cellular function in ways that circumvent normal signaling pathways. Additionally, UFPs can penetrate intracellularly and potentially cause DNA damage. The recent advances in nanotechnology, although opening up new opportunities for the advancement of technology and medicine, could also lead to unforeseen adverse health effects in exposed human subjects. Further research is needed to clarify the safety of nanoscale particles, as well as the elucidation of the possible beneficial use of these particulates to treat disease. C1 [Li, Ning] Michigan State Univ, CVM, Dept Pathol & Diagnost Invest, E Lansing, MI 48824 USA. [Georas, Steve] Univ Rochester, Sch Med, Dept Med, Rochester, NY 14627 USA. [Alexis, Neil] Univ N Carolina, Ctr Environm Med & Lung Biol, Chapel Hill, NC USA. [Fritz, Patricia] New York State Dept Hlth, Albany, NY 12237 USA. [Xia, Tian; Nel, Andre] Univ Calif Los Angeles, Dept Med, Div NanoMed, Los Angeles, CA 90024 USA. [Williams, Marc A.] US Army Publ Hlth Command, Hlth Effects Res Program, Toxicol Portfolio, Aberdeen Proving Ground, MD USA. [Horner, Elliott] UL Environm, Marietta, GA USA. RP Nel, A (reprint author), 10833 Le Conte Ave,52-175 CHS, Los Angeles, CA 90095 USA.; Li, N (reprint author), 1129 Farm Lane B43, E Lansing, MI 48840 USA. EM lining3@msu.edu; ANel@mednet.ucla.edu RI xia, tian/C-3158-2013 OI xia, tian/0000-0003-0123-1305 FU NSF [DBI-1266377]; NIEHS [U19ES019528, P30 ES01247] FX Supported by grants NSF DBI-1266377 (to A.N.), NIEHS U19ES019528 (to A.N.), and NIEHS P30 ES01247 (to S.G.). NR 135 TC 2 Z9 2 U1 16 U2 17 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0091-6749 EI 1097-6825 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD AUG PY 2016 VL 138 IS 2 BP 386 EP 396 DI 10.1016/j.jaci.2016.02.023 PG 11 WC Allergy; Immunology SC Allergy; Immunology GA DS5PY UT WOS:000380835800007 PM 27130856 ER PT J AU Aboul-Enein, BH Puddy, W AF Aboul-Enein, Basil H. Puddy, William TI Contributions of Antoine Barthelemy Clot (1793-1868): A historiographical reflection of public health in Ottoman Egypt SO JOURNAL OF MEDICAL BIOGRAPHY LA English DT Article DE Clot Bey; Egypt; public health; Muhammad Ali Pasha ID POLIO VACCINE AB This paper reviews the selected historiographic and contemporary literature that discussed the medical and public health contribution of Antoine Barthelemy Clot (Clot Bey) and how these contributions shaped modern public health in Ottoman Egypt, and the major features that led to the development of the public health infrastructure of early modern Egypt based on the contributions of Clot Bey. The literature discussed the establishment of Egypt's first modern public health and medical schools under the direct administration and guidance of Clot Bey, and his major contribution in the fields of vaccination, quarantine, the development of a culturally congruent curriculum for medical students, and the public health policies and practices enacted during the reign of Muhammad Ali Pasha that addressed major communicable diseases affecting Egypt. With considerable support from the viceroy of Egypt despite popular resistance, Clot Bey significantly modernized Egyptian medicine, medical education and reformed the public health infrastructure. He became one of the preeminent medical figures of nineteenth century Ottoman Egypt. C1 [Aboul-Enein, Basil H.] Univ South Dakota, Sch Hlth Sci, 414 E Clark St, Vermillion, SD 57069 USA. [Puddy, William] US Army, Frostburg, MD USA. RP Aboul-Enein, BH (reprint author), Univ South Dakota, Sch Hlth Sci, 414 E Clark St, Vermillion, SD 57069 USA. EM Basil.AboulEnein@usd.edu NR 39 TC 0 Z9 0 U1 1 U2 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0967-7720 EI 1758-1087 J9 J MED BIOGR JI J. Med. Biogr. PD AUG PY 2016 VL 24 IS 3 BP 427 EP 432 DI 10.1177/0967772015584708 PG 6 WC History & Philosophy Of Science SC History & Philosophy of Science GA DU8FT UT WOS:000382449400023 PM 26025850 ER PT J AU Rodriguez, V Kairalla, J Salzer, WL Raetz, EA Loh, MLC Carroll, AJ Heerema, NA Wood, BL Borowitz, MJ Burke, MJ Asselin, BL Devidas, M Winick, NJ Carroll, WL Hunger, SP Dreyer, ZE AF Rodriguez, Vilmarie Kairalla, John Salzer, Wanda L. Raetz, Elizabeth A. Loh, Mignon L. C. Carroll, Andrew J. Heerema, Nyla A. Wood, Brent L. Borowitz, Michael J. Burke, Michael J. Asselin, Barbara L. Devidas, Meenakshi Winick, Naomi J. Carroll, William L. Hunger, Stephen P. Dreyer, ZoAnn E. TI A Pilot Study of Intensified PEG-Asparaginase in High-risk Acute Lymphoblastic Leukemia: Children's Oncology Group Study AALL08P1 SO JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY LA English DT Article DE intensified asparaginase; acute lymphoblastic leukemia; high risk; toxicities ID DOSE L-ASPARAGINASE; IMPROVES SURVIVAL; THERAPY; ADOLESCENTS; THROMBOSIS; LYMPHOMA AB AALL08P1 was designed to determine whether biweekly intensified pegaspargase (I-PEG) was feasible and safe in pediatric patients with newly diagnosed high-risk B-precursor lymphoblastic leukemia when given with Children's Oncology Group hemiaugmented BFM therapy. High-risk average (HR-Avg) patients received standard pegaspargase dosing (6 doses), whereas high-risk high (HR-High) patients received I-PEG biweekly from the start of Consolidation until day 1 of Maintenance. Feasibility and safety were defined in advance as 65% of patients tolerating at least 8 doses of I-PEG and 90% requiring 49 weeks from day 1 of Consolidation to the initiation of Maintenance. Targeted toxicities included allergic reactions, anaphylaxis, pancreatitis, thrombosis, bleeding, central nervous system events, and sepsis. AALL08P1 enrolled 104 patients; 54 were classified as HR-Avg and 30 as HR-High after completion of induction therapy. Only 53% (16/30) of the HR-High patients received 8 total doses of I-PEG and 50% (15/30) took 49 weeks from start of Consolidation to the initiation of Maintenance. I-PEG did not significantly increase grade 2 to 5 targeted toxicities. I-PEG was not feasible or safe as defined in AALL08P1. Complete assessment of this regimen was limited due to removal of patients from I-PEG regimen and early closure of the study. C1 [Rodriguez, Vilmarie] Mayo Clin, Childrens Ctr, Div Pediat Hematol Oncol, Rochester, MN USA. [Kairalla, John; Devidas, Meenakshi] Univ Florida, Childrens Oncol Grp, Data Ctr Biostat, Gainesville, FL USA. [Salzer, Wanda L.] US Army Med Res & Mat Command, Congressionally Directed Med Res Program, Walter Reed Natl Mil Med Ctr, Ft Detrick, MD USA. [Borowitz, Michael J.] Johns Hopkins Univ, Dept Pathol, Sidney Kimmel Canc Ctr, Baltimore, MD USA. [Raetz, Elizabeth A.] Univ Utah, Div Pediat Hematol Oncol, Primary Childrens Hosp, Salt Lake City, UT USA. [Loh, Mignon L. C.] UCSF Med Ctr Mss Bay, Div Pediat Hematol Oncol, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA USA. [Carroll, Andrew J.] Univ Alabama Birmingham, Childrens Hosp Alabama, Dept Genet, Birmingham, AL USA. [Heerema, Nyla A.] Ohio State Univ, Nationwide Childrens Hosp, Cytogenet, Columbus, OH 43210 USA. [Wood, Brent L.] Seattle Childrens Hosp, Lab Med, Seattle, WA USA. [Burke, Michael J.] MACC Fund Res Ctr, Midwest Childrens Canc Ctr, Milwaukee, WI USA. [Asselin, Barbara L.] Univ Rochester, Med Ctr, Div Pediat Hematol Oncol, Rochester, NY 14642 USA. [Carroll, William L.] NYU Langone, Laura & Isaac Perlmutter Canc Ctr, Hassendfeld Childrens Ctr, New York, NY USA. [Winick, Naomi J.] UT Southwestern Simmons Canc Ctr, Div Pediat Hematol Oncol, Dallas, TX USA. [Dreyer, ZoAnn E.] Baylor Coll Med, Ctr Comprehens Canc, Pediat Oncol, Houston, TX 77030 USA. [Hunger, Stephen P.] Childrens Hosp Philadelphia, Div Oncol, Philadelphia, PA 19104 USA. [Hunger, Stephen P.] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA. RP Rodriguez, V (reprint author), Mayo Clin, 200 First St SW, Rochester, MN 55905 USA. EM Rodriguez.Vilmarie@mayo.edu FU National Cancer Institute to the Children's Oncology Group [CA98543, CA180886]; National Cancer Institute to the Children's Oncology Group (Statistics and Data Center) [CA180886, CA98413]; Sigma Tau Pharmaceuticals; Jazz Pharmaceuticals FX Supported by grants from National Cancer Institute to the Children's Oncology Group (Chair's Grant CA98543 and CA180886 and Statistics and Data Center Grant CA98413 and CA180886).r S.P.H. has received consulting fees from Sigma Tau Pharmaceuticals and Jazz Pharmaceuticals. The remaining authors declare no conflict of interest. NR 27 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1077-4114 EI 1536-3678 J9 J PEDIAT HEMATOL ONC JI J. Pediatr. Hematol. Oncol. PD AUG PY 2016 VL 38 IS 6 BP 409 EP 417 DI 10.1097/MPH.0000000000000589 PG 9 WC Oncology; Hematology; Pediatrics SC Oncology; Hematology; Pediatrics GA DU9SP UT WOS:000382558300008 PM 27299599 ER PT J AU Sauer, EL Sperry, JH Rohr, JR AF Sauer, Erin L. Sperry, Jinelle H. Rohr, Jason R. TI An efficient and inexpensive method for measuring long-term thermoregulatory behavior SO JOURNAL OF THERMAL BIOLOGY LA English DT Article DE Thermoregulation; Thermal preference; Thermoregulatory behavior; Experimental design ID CLIMATE-CHANGE; TEMPERATURE REGULATION; THERMAL SENSITIVITY; BODY TEMPERATURES; ECTOTHERMS; FEVER; ECOLOGY; LIZARD; SNAKES; RISK AB Thermoregulatory ability and behavior influence organismal responses to their environment. By measuring thermal preferences, researchers can better understand the effects that temperature tolerances have on ecological and physiological responses to both biotic and abiotic stressors. However, because of funding limitations and confounders, measuring thermoregulation can often be difficult. Here, we provide an effective, affordable (similar to$50 USD per unit), easy to construct, and validated apparatus for measuring the long-term thermal preferences of animals. In tests, the apparatus spanned temperatures from 9.29 to 33.94 degrees C, and we provide methods to further increase this range. Additionally, we provide simple methods to non-invasively measure animal and substrate temperatures and to prevent temperature preferences of the focal organisms from being confounded with temperature preferences of its prey and its humidity preferences. To validate the apparatus, we show that it was capable of detecting individual level consistency and among individual-level variation in the preferred body temperatures of Southern toads (Anaxyrus terrestris) and Cuban tree frogs (Osteopilus septentrionalis) over three-weeks. Nearly every aspect of our design is adaptable to meet the needs of a multitude of study systems, including various terrestrial amphibious, and aquatic organisms. The apparatus and methods described here can be used to quantify behavioral thermal preferences, which can be critical for determining temperature tolerances across species and thus the resiliency of species to current and impending climate change. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Sauer, Erin L.; Rohr, Jason R.] Univ S Florida, Dept Integrat Biol, 4202 E Fowler Ave,SCA 110, Tampa, FL 33620 USA. [Sperry, Jinelle H.] Engineer Res & Dev Ctr, POB 9005, Champaign, IL 61826 USA. RP Sauer, EL (reprint author), Univ S Florida, Dept Integrat Biol, 4202 E Fowler Ave,SCA 110, Tampa, FL 33620 USA. EM erinsauer@mail.usf.edu FU National Science Foundation [EF-1241889]; National Institutes of Health [R01GM109499, R01TW010286]; US Department of Agriculture [NRI 2006-01370, 2009-35102-0543]; US Environmental Protection Agency [83518801] FX This research was supported by grants from the National Science Foundation (EF-1241889), National Institutes of Health (R01GM109499 and R01TW010286), US Department of Agriculture (NRI 2006-01370 and 2009-35102-0543), and US Environmental Protection Agency (CAREER 83518801) to J.R.R. NR 52 TC 1 Z9 1 U1 19 U2 19 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0306-4565 J9 J THERM BIOL JI J. Therm. Biol. PD AUG PY 2016 VL 60 BP 231 EP 236 DI 10.1016/j.jtherbio.2016.07.016 PG 6 WC Biology; Zoology SC Life Sciences & Biomedicine - Other Topics; Zoology GA DU6UI UT WOS:000382349700028 PM 27503737 ER PT J AU Williams, TK Neff, LP Johnson, MA Ferencz, SA Davidson, AJ Russo, RM Rasmussen, TE AF Williams, Timothy Keith Neff, Lucas P. Johnson, Michael Austin Ferencz, Sarah-Ashley Davidson, Anders J. Russo, Rachel M. Rasmussen, Todd E. TI Extending resuscitative endovascular balloon occlusion of the aorta: Endovascular variable aortic control in a lethal model of hemorrhagic shock SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE REBOA; endovascular variable aortic control; hemorrhage control; aortic occlusion; swine ID FLUID RESUSCITATION; DESCENDING AORTA; PORCINE MODEL; REBOA AB BACKGROUND: The duration of use and efficacy of resuscitative endovascular balloon occlusion of the aorta (REBOA) is limited by distal ischemia. We developed a hybrid endovascular-extracorporeal circuit variable aortic control (VAC) device to extend REBOA duration in a lethal model of hemorrhagic shock to serve as an experimental surrogate to further the development of endovascular VAC (EVAC) technologies. METHODS: Nine Yorkshire-cross swine were anesthetized, instrumented, splenectomized, and subjected to 30% liver amputation. Following a short period of uncontrolled hemorrhage, REBOA was instituted for 20 minutes. Automated variable occlusion in response to changes in proximal mean arterial pressure was applied for the remaining 70 minutes of the intervention phase using the automated extracorporeal circuit. Damage-control surgery and whole blood resuscitation then occurred, and the animals were monitored for a total of 6 hours. RESULTS: Seven animals survived the initial surgical preparation. After 20 minutes of complete REBOA, regulated flow was initiated through the extracorporeal circuit to simulate VAC and provide perfusion to distal tissue beds during the 90-minute intervention phase. Two animals required circuit occlusion for salvage, while five animals tolerated sustained, escalating restoration of distal blood flow before surgical hemorrhage control. Animals tolerating distal flow had preserved renal function, maintained proximal blood pressure, and rapidly weaned from complete REBOA. CONCLUSION: We combined a novel automated, extracorporeal circuit with complete REBOA to achieve EVAC in a swine model of uncontrolled hemorrhage. Our approach regulated proximal aortic pressure, alleviated supranormal values above the balloon, and provided controlled distal aortic perfusion that reduced ischemia without inducing intolerable bleeding. This experimental model serves as a temporary surrogate to guide future EVAC catheter designs that may provide transformational approaches to hemorrhagic shock. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved. C1 [Williams, Timothy Keith] David Grant USAF Med Ctr, Dept Vasc & Endovasc Surg, Travis Afb, CA 94535 USA. [Williams, Timothy Keith; Neff, Lucas P.] David Grant USAF Med Ctr, Clin Invest Facil, Travis Afb, CA USA. [Neff, Lucas P.] David Grant USAF Med Ctr, Dept Gen Surg, Travis Afb, CA USA. [Johnson, Michael Austin] Univ Calif Davis, Med Ctr, Dept Emergency Med, Sacramento, CA 95817 USA. [Ferencz, Sarah-Ashley; Davidson, Anders J.; Russo, Rachel M.] Univ Calif Davis, Med Ctr, Dept Surg, Sacramento, CA 95817 USA. [Rasmussen, Todd E.] US Army, US Combat Casualty Care Res Program, Med Res & Mat Command, Ft Detrick, MD USA. RP Williams, TK (reprint author), David Grant USAF Med Ctr, Dept Vasc & Endovasc Surg, Travis Afb, CA 94535 USA. EM timothy.williams.72@us.af.mil FU Clinical Investigation Facility, David Grant USAF Medical Center, Travis Air Force Base, California FX There was no funding from the National Institutes of Health (NIH), Wellcome Trust, or the Howard Hughes Medical Institute (HHMI) for this work. No conflicts of interest were declared by any of the authors. The Clinical Investigation Facility, David Grant USAF Medical Center, Travis Air Force Base, California, provided funding for this study. NR 17 TC 2 Z9 2 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD AUG PY 2016 VL 81 IS 2 BP 294 EP 301 DI 10.1097/TA.0000000000001075 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA DS5CE UT WOS:000380797300012 PM 27070441 ER PT J AU Jahnke, JP Terrell, JL Smith, AM Cheng, XH Stratis-Cullum, DN AF Jahnke, Justin P. Terrell, Jessica L. Smith, Austin M. Cheng, Xuanhong Stratis-Cullum, Dimitra N. TI Influences of Adhesion Variability on the "Living" Dynamics of Filamentous Bacteria in Microfluidic Channels SO MOLECULES LA English DT Article DE filamentous bacteria; fimbriae; mannosylated substrate; adhesion; orientation; microfluidic; buckle; shear flow ID UROPATHOGENIC ESCHERICHIA-COLI; URINARY-TRACT-INFECTIONS; BIOFILM FORMATION; TYPE-1 FIMBRIAE; CELL-DIVISION; BINDING PEPTIDES; SHAPE; SURFACE; SHEAR; MOTILITY AB Microfabricated devices have increasingly incorporated bacterial cells for microscale studies and exploiting cell-based functions in situ. However, the role of surface interactions in controlling the bacterial cell behavior is not well understood. In this study, microfluidic substrates of varied bacterial-binding affinity were used to probe the interaction-driven behavior of filamentous Escherichia coli. In particular, cell alignment under controlled shear flow as well as subsequent orientation and filamentation were compared between cells presenting distinct outer membrane phenotypes. We demonstrated that filaments retained position under flow, which allowed for dynamic single-cell monitoring with in situ elongation of over 100 mu m for adherent cells. This maximum was not reached by planktonic cells and was, therefore, adhesion-dependent. The bound filaments initially aligned with flow under a range of flow rates and their continual elongation was traced in terms of length and growth path; analysis demonstrated that fimbriae-mediated adhesion increased growth rate, increased terminal length, as well as dramatically changed the adherent geometry, particularly buckling behavior. The effects to filament length and buckling were further exaggerated by the strongest, specificity-driven adhesion tested. Such surface-guided control of the elongation process may be valuable to yield interesting "living" filamentous structures in microdevices. In addition, this work may offer a biomedically relevant platform for further elucidation of filamentation as an immune-resistant morphology. Overall, this work should inspire broader exploration of microfabricated devices for the study and application of single bacterial cells. C1 [Jahnke, Justin P.; Terrell, Jessica L.; Smith, Austin M.; Stratis-Cullum, Dimitra N.] US Army Res Lab, Adelphi, MD 20783 USA. [Cheng, Xuanhong] Lehigh Univ, Dept Mat Sci & Engn, Bioengn Program, Bethlehem, PA 18015 USA. RP Stratis-Cullum, DN (reprint author), US Army Res Lab, Adelphi, MD 20783 USA.; Cheng, XH (reprint author), Lehigh Univ, Dept Mat Sci & Engn, Bioengn Program, Bethlehem, PA 18015 USA. EM justin.jahnke2.ctr@mail.mil; jessica.l.terrell7.ctr@mail.mil; austin.smith2@utsa.edu; xuc207@lehigh.edu; dimitra.n.stratis-cullum.civ@mail.mil FU U.S. Army Research Laboratory (ARL) Postdoctoral Fellowship Program; Oak Ridge Associated Universities; University of Texas at San Antonio Top Scholar Program; U.S. Department of the Defense, Defense Threat Reduction Agency [HDTRA1-12-1-0007]; Army Research Office [W911NF-14-1-0665]; Faculty Enhancement Grant from Lehigh University FX This project was supported in part by appointments to the U.S. Army Research Laboratory (ARL) Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through a contract with ARL. It was also sponsored in part by the University of Texas at San Antonio Top Scholar Program. Further financial support was received from the U.S. Department of the Defense, Defense Threat Reduction Agency under Contract No. HDTRA1-12-1-0007 and Army Research Office under Contract No. W911NF-14-1-0665. Xuanhong Cheng is grateful for the Faculty Enhancement Grant from Lehigh University for partially supporting her sabbatical effort at ARL. Hang Li at Lehigh University generously helped prepare the microfluidic devices. E. coli strains and plasmids were generously donated from E. V. Sokurenko and I. C. Blomfield. NR 75 TC 1 Z9 1 U1 13 U2 13 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 1420-3049 J9 MOLECULES JI Molecules PD AUG PY 2016 VL 21 IS 8 AR 985 DI 10.3390/molecules21080985 PG 15 WC Chemistry, Organic SC Chemistry GA DU6ON UT WOS:000382334600024 ER PT J AU Kragh, JF Lunati, MP Kharod, CU Cunningham, CW Bailey, JA Stockinger, ZT Cap, AP Chen, J Aden, JK Cancio, LC AF Kragh, John F., Jr. Lunati, Matthew P. Kharod, Chetan U. Cunningham, Cord W. Bailey, Jeffrey A. Stockinger, Zsolt T. Cap, Andrew P. Chen, Jacob Aden, James K. Cancio, Leopoldo C. TI Assessment of Groin Application of Junctional Tourniquets in a Manikin Model SO PREHOSPITAL AND DISASTER MEDICINE LA English DT Article DE Emergency Medical Services; hemorrhage; tourniquet ID HEMORRHAGE AB Introduction To aid in preparation of military medic trainers for a possible new curriculum in teaching junctional tourniquet use, the investigators studied the time to control hemorrhage and blood volume lost in order to provide evidence for ease of use. Hypothesis Models of junctional tourniquet could perform differentially by blood loss, time to hemostasis, and user preference. Methods In a laboratory experiment, 30 users controlled simulated hemorrhage from a manikin (Combat Ready Clamp [CRoC] Trainer) with three iterations each of three junctional tourniquets. There were 270 tests which included hemorrhage control (yes/no), time to hemostasis, and blood volume lost. Users also subjectively ranked tourniquet performance. Models included CRoC, Junctional Emergency Treatment Tool (JETT), and SAM Junctional Tourniquet (SJT). Time to hemostasis and total blood loss were log-transformed and analyzed using a mixed model analysis of variance (ANOVA) with the users represented as random effects and the tourniquet model used as the treatment effect. Preference scores were analyzed with ANOVA, and Tukey's honest significant difference test was used for all post-hoc pairwise comparisons. Results All tourniquet uses were 100% effective for hemorrhage control. For blood loss, CRoC and SJT performed best with least blood loss and were significantly better than JETT; in pairwise comparison, CRoC-JETT (P < .0001) and SJT-JETT (P = .0085) were statistically significant in their mean difference, while CRoC-SJT (P = .35) was not. For time to hemostasis in pairwise comparison, the CRoC had a significantly shorter time compared to JETT and SJT (P < .0001, both comparisons); SJT-JETT was also significant (P = .0087). In responding to the directive, Rank the performance of the models from best to worst, users did not prefer junctional tourniquet models differently (P > .5, all models). Conclusion The CRoC and SJT performed best in having least blood loss, CRoC performed best in having least time to hemostasis, and users did not differ in preference of model. Models of junctional tourniquet performed differentially by blood loss and time to hemostasis. C1 [Kragh, John F., Jr.; Bailey, Jeffrey A.; Stockinger, Zsolt T.; Cap, Andrew P.; Chen, Jacob; Aden, James K.; Cancio, Leopoldo C.] US Army Inst Surg Res, Damage Control Resuscitat, Jbsa Ft Sam Houston, TX USA. [Lunati, Matthew P.] Univ Texas Hlth Sci Ctr San Antonio, Sch Med, San Antonio, TX 78229 USA. [Kharod, Chetan U.; Cunningham, Cord W.] San Antonio Mil Med Ctr, Emergency Med Serv, Jbsa Ft Sam Houston, TX USA. RP Kragh, JF (reprint author), US Army Inst Surg Res, 3698 Chambers Pass,Bldg 3611,Rm 222-4, Jbsa Ft Sam Houston, TX 78234 USA. EM John.f.kragh.civ@mail.mil OI Kharod, Chetan/0000-0003-4352-8887 NR 16 TC 0 Z9 0 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1049-023X EI 1945-1938 J9 PREHOSPITAL DISASTER JI Prehospital Disaster Med. PD AUG PY 2016 VL 31 IS 4 BP 358 EP 363 DI 10.1017/S1049023X16000443 PG 6 WC Emergency Medicine SC Emergency Medicine GA DU7FG UT WOS:000382378100004 PM 27230520 ER PT J AU Muir, SL Sheppard, LB Maika-Wilson, A Burgert, JM Garcia-Blanco, J Johnson, AD Coyner, JL AF Muir, Stacy L. Sheppard, Lance B. Maika-Wilson, Anne Burgert, James M. Garcia-Blanco, Jose Johnson, Arthur D. Coyner, Jennifer L. TI A Comparison of the Effects of Intraosseous and Intravenous 5% Albumin on Infusion Time and Hemodynamic Measures in a Swine Model of Hemorrhagic Shock SO PREHOSPITAL AND DISASTER MEDICINE LA English DT Article DE albumin; hemorrhagic shock; infusion time; intraosseous; resuscitation ID NATURAL COLLOID RESUSCITATION; FREEZE-DRIED PLASMA; LIFE-SUPPORT; CARDIOPULMONARY-RESUSCITATION; DILUTIONAL COAGULOPATHY; INCREASING HEMORRHAGE; HEXTEND RESUSCITATION; LACTATED RINGERS; VASCULAR ACCESS; FEMUR INJURY AB Introduction Obtaining intravenous (IV) access in patients in hemorrhagic shock is often difficult and prolonged. Failed IV attempts delay life-saving treatment. Intraosseous (IO) access may often be obtained faster than IV access. Albumin (5%) is an option for prehospital volume expansion because of the absence of interference with coagulation and platelet function. Hypothesis/Problem There are limited data comparing the performance of IO and IV administered 5% albumin. The aims of this study were to compare the effects of tibial IO (TIO) and IV administration of 500 mL of 5% albumin on infusion time and hemodynamic measurements of heart rate (HR), mean arterial pressure (MAP), cardiac output (CO), and stroke volume (SV) in a swine model of hemorrhagic shock. Methods Sixteen male swine were divided into two groups: TIO and IV. All subjects were anesthetized and a Class III hemorrhage was achieved by exsanguination of 31% of estimated blood volume (EBV) from a femoral artery catheter. Following exsanguination, 500 mL of 5% albumin was administered under pressurized infusion (300 mmHg) by the TIO or IV route and infusion time was recorded. Hemodynamic measurements of HR, MAP, CO, and SV were collected before and after exsanguination and every 20 seconds for 180 seconds during 5% albumin infusion. Results An independent t-test determined that IV 5% albumin infusion was significantly faster compared to IO (P=.01). Mean infusion time for TIO was seven minutes 35 seconds (SD=two minutes 44 seconds) compared to four minutes 32 seconds (SD=one minute 08 seconds) in the IV group. Multivariate Analysis of Variance was performed on hemodynamic data collected during the 5% albumin infusion. Analyses indicated there were no significant differences between the TIO and IV groups relative to MAP, CO, HR, or SV (P>.05). Conclusion While significantly longer to infuse 5% albumin by the TIO route, the longer TIO infusion time may be negated as IO devices can be placed more quickly compared to repeated IV attempts. The lack of significant difference between the TIO and IV routes relative to hemodynamic measures indicate the TIO route is a viable route for the infusion of 5% albumin in a swine model of Class III hemorrhage. C1 [Muir, Stacy L.; Sheppard, Lance B.; Maika-Wilson, Anne; Burgert, James M.; Johnson, Arthur D.; Coyner, Jennifer L.] Northeastern Univ, US Army Med Dept Ctr & Sch, US Army Grad Program Anesthesia Nursing, Ft Sam Houston, TX USA. [Burgert, James M.; Garcia-Blanco, Jose; Johnson, Arthur D.] Geneva Fdn, Tacoma, WA USA. RP Burgert, JM (reprint author), Northeastern Univ, US Army Med Dept & Sch, US Army Grad Program Anesthesia Nursing, 3490 Forage Rd Suite 112, Ft Sam Houston, TX 78234 USA. EM james.burgert@alumni.bcm.edu OI Burgert, James/0000-0001-8346-6196 NR 29 TC 1 Z9 1 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1049-023X EI 1945-1938 J9 PREHOSPITAL DISASTER JI Prehospital Disaster Med. PD AUG PY 2016 VL 31 IS 4 BP 436 EP 442 DI 10.1017/S1049023X16000509 PG 7 WC Emergency Medicine SC Emergency Medicine GA DU7FG UT WOS:000382378100014 PM 27210025 ER PT J AU Bonnell, FB AF Bonnell, Francoise B. TI SS John W. Brown Museum SO PUBLIC HISTORIAN LA English DT Art Exhibit Review C1 [Bonnell, Francoise B.] US Army Womens Museum, Ft Lee, VA 23801 USA. RP Bonnell, FB (reprint author), US Army Womens Museum, Ft Lee, VA 23801 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU UNIV CALIFORNIA PRESS PI OAKLAND PA 155 GRAND AVE, SUITE 400, OAKLAND, CA 94612-3758 USA SN 0272-3433 J9 PUBL HISTORIAN JI Public Hist. PD AUG PY 2016 VL 38 IS 3 BP 139 EP 144 PG 6 WC History SC History GA DT9QC UT WOS:000381836400013 ER PT J AU April, MD April, CW Schauer, SG Maddry, JK Sessions, DJ Davis, WT Ng, PC Oliver, J Delorenzo, RA AF April, Michael D. April, Carolyn W. Schauer, Steven G. Maddry, Joseph K. Sessions, Daniel J. Davis, W. Tyler Ng, Patrick C. Oliver, Joshua Delorenzo, Robert A. TI Optimizing Military Human Subjects Protection and Research Productivity: The Role of Institutional Memory SO AMERICAN JOURNAL OF BIOETHICS LA English DT Editorial Material C1 [April, Michael D.; Schauer, Steven G.; Maddry, Joseph K.; Sessions, Daniel J.; Davis, W. Tyler; Ng, Patrick C.; Oliver, Joshua] San Antonio Uniformed Serv Hlth Educ Consortium, Joint Base San Antonio, TX 78234 USA. [April, Carolyn W.; Delorenzo, Robert A.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Schauer, Steven G.; Maddry, Joseph K.] US Army Inst Surg Res, San Antonio, TX USA. RP April, MD (reprint author), San Antonio Uniformed Serv Hlth Educ Consortium, Dept Emergency Med, Joint Base San Antonio, TX 78234 USA. EM Michael.D.April@post.harvard.edu FU Oak Ridge Institute for Science and Engineeering FX Michael D. April, Steven G. Schauer, Joseph K. Maddry, Daniel J. Sessions, W. Tyler Davis, Patrick C. Ng, and Joshua Oliver are active duty service members. Robert A. Delorenzo is a consultant to the United States Army Institute for Surgical Research with a stipend paid by Oak Ridge Institute for Science and Engineeering. NR 10 TC 0 Z9 0 U1 1 U2 1 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1526-5161 EI 1536-0075 J9 AM J BIOETHICS JI Am. J. Bioeth. PD AUG PY 2016 VL 16 IS 8 BP 43 EP 45 DI 10.1080/15265161.2016.1187222 PG 3 WC Ethics; Medical Ethics; Social Issues; Social Sciences, Biomedical SC Social Sciences - Other Topics; Medical Ethics; Social Issues; Biomedical Social Sciences GA DS6OI UT WOS:000380901100018 PM 27366849 ER PT J AU Smith-Forbes, EV Howell, DM Willoughby, J Armstrong, H Pitts, DG Uhl, TL AF Smith-Forbes, Enrique V. Howell, Dana M. Willoughby, Jason Armstrong, Hilary Pitts, Donald G. Uhl, Tim L. TI Adherence of Individuals in Upper Extremity Rehabilitation: A Qualitative Study SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Article; Proceedings Paper CT Meeting of Association-of-Military-Surgeons-of-the-United-States CY DEC 05, 2014 CL Washington, DC SP Assoc Mil Surg US DE Compliance; Patient satisfaction; Qualitative research; Rehabilitation; Upper extremity ID HAND THERAPY; HEALTH; COMMUNICATION; QUICKDASH; CARE AB Objective: To describe the rehabilitation experiences, expectations, and treatment adherence of patients receiving upper extremity (UE) rehabilitation who demonstrated discrepancy between functional gains and overall improvement. Design: Qualitative (phenomenologic) interviews and analysis. Setting: Outpatient UE rehabilitation. Participants: Patients with acute UE injuries (N=10). Interventions: Not applicable. Main Outcome Measure: Concerns related to UE rehabilitation patients demonstrating discrepancy between outcome measures. Results: Five key themes emerged from the interviews of patients demonstrating discrepancy in their self-reported patient outcomes: (1) desire to return to normal, (2) initial anticipation of brief recovery, (3) trust of therapist, (4) cannot stop living, and (5) feelings of ambivalence. Challenges included living with the desire to move back into life. Multiple factors affected patient adherence: cost of treatment, patient-provider relation (difference between therapist and patient understanding on what is important for treatment), and patients expecting the treating therapists to be an expert and fix their problem. Conclusions: Patient adherence to UE rehabilitation presents many challenges. Patients view themselves as laypersons and seek the knowledge of a dedicated therapist who they trust to spend time with them to understand what they value as important and clarify their injury, collaboratively make goals, and explain the intervention to get them in essence, back into life, in the minimal required time. When categorized according to the World Health Organization's multidimensional adherence model, domains identified in this model include social and economic, health care team and system, condition-related, therapy-related, and patient-related dimensions. Assessing factors identified to improve efficiency and effectiveness of clinical management can enhance patient adherence. (C) 2016 by the American Congress of Rehabilitation Medicine C1 [Smith-Forbes, Enrique V.; Howell, Dana M.; Uhl, Tim L.] Univ Kentucky, Dept Rehabil Sci, Coll Hlth Sci, Lexington, KY 40506 USA. [Smith-Forbes, Enrique V.] US Army, Grad Med Educ, Ft Sam Houston, TX USA. [Howell, Dana M.] Eastern Kentucky Univ, Dept Occupat Therapy, Richmond, KY 40475 USA. [Willoughby, Jason; Armstrong, Hilary; Pitts, Donald G.] Drayer Phys Therapy Inst, Kentucky Hand & Phys Therapy, Lexington, KY USA. RP Smith-Forbes, EV (reprint author), Ft Sam Houston Clin, Grad Med Educ, Bldg 1179,Rm 1A38,3100 Schofield Rd, Ft Sam Houston, TX 78234 USA. EM enrique.smith-forbes@uky.edu NR 18 TC 0 Z9 0 U1 3 U2 3 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0003-9993 EI 1532-821X J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD AUG PY 2016 VL 97 IS 8 BP 1262 EP 1268 DI 10.1016/j.apmr.2015.11.008 PG 7 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA DT1LM UT WOS:000381244200007 PM 26702766 ER PT J AU Kuehn, JT AF Kuehn, John T. TI Torch: North Africa and the Allied path to victory SO MARINERS MIRROR LA English DT Book Review C1 [Kuehn, John T.] US Army, Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. RP Kuehn, JT (reprint author), US Army, Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0025-3359 EI 2049-680X J9 MARINERS MIRROR JI Mar. Mirror PD AUG PY 2016 VL 102 IS 3 BP 374 EP 377 DI 10.1080/00253359.2016.1196004 PG 4 WC History SC History GA DT2ZY UT WOS:000381351500029 ER PT J AU Hakre, S Blaylock, JM Dawson, P Beckett, C Garges, EC Michael, NL Danaher, PJ Scott, PT Okulicz, JF AF Hakre, Shilpa Blaylock, Jason M. Dawson, Peter Beckett, Charmagne Garges, Eric C. Michael, Nelson L. Danaher, Patrick J. Scott, Paul T. Okulicz, Jason F. TI Knowledge, attitudes, and beliefs about HIV pre-exposure prophylaxis among US Air Force Health Care Providers SO MEDICINE LA English DT Article DE HIV pre-exposure prophylaxis; US Air Force; providers ID UNITED-STATES; PREVENTION; PREP; PRESCRIPTION; INFECTION; MEN AB Providers are central to effective implementation of HIV pre-exposure prophylaxis (PrEP). Primary care providers (PCP) and infectious disease physicians (ID) in the US Air Force (USAF) participated in a cross-sectional survey regarding knowledge, attitudes, and beliefs toward HIV PrEP. Characteristics associated with PrEP knowledge were assessed in univariate and multivariate analyses. Among 403 (40% of 1015 providers) participants, 9% (PCP 383, ID 20) ever prescribed PrEP. In univariate analysis, years in practice, number of HIV-infected patients treated in the past 12 months, past prescription of antiretrovirals for HIV prevention, frequency of prescribing PrEP in the past 12 months, and ever being questioned by a patient about PrEP were associated with PrEP knowledge (P < 0.05). In multivariate analysis, providers who had ever prescribed antiretrovirals to prevent HIV (AOR: 2.37, 95% CI: 1.27-4.42) had greater odds of high PrEP knowledge. Despite concerns about medication side effects (overall 67%: PCP 68%, ID 85%) and prescribing PrEP without clear evidence (overall 60%: PCP 65%, ID 62%), 64% (PCP 65%, ID 85%) of participants indicated PrEP should be offered in the Military Health System and 68% (PCP 70%, ID 100%) disagreed with the statement that their patient population was not at risk for HIV infection. Successful PrEP implementation in the USAF will require continued education and training of primary care providers to improve knowledge and mitigate concerns about PrEP. C1 [Hakre, Shilpa; Michael, Nelson L.; Scott, Paul T.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Hakre, Shilpa] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Blaylock, Jason M.; Beckett, Charmagne] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. [Dawson, Peter] EMMES Corp, Rockville, MD USA. [Beckett, Charmagne] Navy Bloodborne Infect Management Ctr, Bethesda, MD USA. [Garges, Eric C.] Army Publ Hlth Ctr Provis, Aberdeen Proving Ground, MD USA. [Danaher, Patrick J.; Okulicz, Jason F.] San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX USA. RP Hakre, S (reprint author), US Mil HIV Res Program, Epidemiol & Threat Assessment, 6720A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA. EM shakre@hivresearch.org FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-11-2-0174]; US Department of Defense (DoD) [W81XWH-11-2-0174] FX This work was supported by a cooperative agreement (W81XWH-11-2-0174) between The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (HJF), and the US Department of Defense (DoD). NR 32 TC 0 Z9 0 U1 3 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0025-7974 EI 1536-5964 J9 MEDICINE JI Medicine (Baltimore) PD AUG PY 2016 VL 95 IS 32 AR e4511 DI 10.1097/MD.0000000000004511 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA DU5IX UT WOS:000382246500035 PM 27512869 ER PT J AU Heipertz, RA Ayemoba, O Sanders-Buell, E Poltavee, K Pham, P Kijak, GH Lei, E Bose, M Howell, S O'Sullivan, AM Bates, A Cervenka, T Kuroiwa, J Akintunde, A Ibezim, O Alabi, A Okoye, O Manak, M Malia, J Peel, S Maisaka, M Singer, D O'Connell, RJ Robb, ML Kim, JH Michael, NL Njoku, O Tovanabutra, S AF Heipertz, Richard A., Jr. Ayemoba, Ojor Sanders-Buell, Eric Poltavee, Kultida Pham, Phuc Kijak, Gustavo H. Lei, Esther Bose, Meera Howell, Shana O'Sullivan, Anne Marie Bates, Adam Cervenka, Taylor Kuroiwa, Janelle Akintunde, Akindiran Ibezim, Onyekachukwu Alabi, Abraham Okoye, Obumneke Manak, Mark Malia, Jennifer Peel, Sheila Maisaka, Mohammed Singer, Darrell O'Connell, Robert J. Robb, Merlin L. Kim, Jerome H. Michael, Nelson L. Njoku, Ogbonnaya Tovanabutra, Sodsai TI Significant contribution of subtype G to HIV-1 genetic complexity in Nigeria identified by a newly developed subtyping assay specific for subtype G and CRF02_AG SO MEDICINE LA English DT Article ID MULTIREGION HYBRIDIZATION ASSAY; IMMUNODEFICIENCY-VIRUS TYPE-1; DRUG-RESISTANCE; DOUBLE-BLIND; MOLECULAR EPIDEMIOLOGY; ANTIRETROVIRAL THERAPY; REVERSE-TRANSCRIPTASE; GENOTYPING ASSAY; HIGH-THROUGHPUT; CENTRAL-AFRICA AB While abundant sequence information is available from human immunodeficiency virus type 1 (HIV-1) subtypes A, B, C and CRF01_AE for HIV-1 vaccine design, sequences from West Africa are less represented. We sought to augment our understanding of HIV-1 variants circulating in 6 Nigerian cities as a step to subsequent HIV-1 vaccine development. The G/CRF02_AG multi-region hybridization assay (MHA) was developed to differentiate subtype G, CRF02_AG and their recombinants from other subtypes based on 7 HIV-1 segments. Plasma from 224 HIV-1 infected volunteers enrolled in a cohort examining HIV-1 prevalence, risk factor, and subtype from Makurdi (30), Abuja (18), Enugu (11), Kaduna (12), Tafa (95), and Ojo/Lagos (58) was analyzed using MHA. HIV-1 genomes from 42 samples were sequenced to validate the MHA and fully explore the recombinant structure of G and CRF02_AG variants. The sensitivity and specificity of MHA varied between 73-100% and 90-100%, respectively. The subtype distribution as identified by MHA among 224 samples revealed 38% CRF02_AG, 28% G, and 26% G/CRF02_AG recombinants while 8% remained nontypeable strains. In envelope (env) gp120, 38.84% of the samples reacted to a G probe while 31.25% reacted to a CRF02 (subtype A) probe. Full genome characterization of 42 sequences revealed the complexity of Nigerian HIV-1 variants. CRF02_AG, subtype G, and their recombinants were the major circulating HIV-1 variants in 6 Nigerian cities. High proportions of samples reacted to a G probe in env gp120 confirms that subtype G infections are abundant and should be considered in strategies for global HIV-1 vaccine development. C1 [Heipertz, Richard A., Jr.; Sanders-Buell, Eric; Poltavee, Kultida; Pham, Phuc; Kijak, Gustavo H.; Lei, Esther; Bose, Meera; Howell, Shana; O'Sullivan, Anne Marie; Bates, Adam; Cervenka, Taylor; Kuroiwa, Janelle; Manak, Mark; Malia, Jennifer; Peel, Sheila; O'Connell, Robert J.; Robb, Merlin L.; Kim, Jerome H.; Michael, Nelson L.; Tovanabutra, Sodsai] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Ayemoba, Ojor; Ibezim, Onyekachukwu; Okoye, Obumneke] Nigerian Minist Def, Emergency Plan Implementat Comm, Abuja, Nigeria. [Sanders-Buell, Eric; Poltavee, Kultida; Pham, Phuc; Kijak, Gustavo H.; Lei, Esther; Bose, Meera; Howell, Shana; O'Sullivan, Anne Marie; Bates, Adam; Cervenka, Taylor; Kuroiwa, Janelle; Manak, Mark; Robb, Merlin L.; Tovanabutra, Sodsai] Henry M Jackson Fdn Adv Mil Med Inc, Bethesda, MD USA. [Akintunde, Akindiran; Alabi, Abraham; Njoku, Ogbonnaya] HJF MRI, US Mil HIV Res Program, Abuja, Nigeria. [Alabi, Abraham] Hop Albert Schweitzer Lambarene, Fdn Int, Ctr Rech Med Lambarene CERMEL, Lambarene, Gabon. [Malia, Jennifer; Singer, Darrell] US PHS, Rockville, MD USA. [Maisaka, Mohammed] 45 Nigerian Air Force Hosp, Makurdi, Nigeria. [Singer, Darrell] Dept Def HIV Program, Abuja, Nigeria. RP Tovanabutra, S (reprint author), Walter Reed Army Inst Res, Attn MHRP Retro, 503 Robert Grant Ave,Room 2N25, Silver Spring, MD 20910 USA. EM stovanabutra@hivresearch.org FU Henry M. Jackson Foundation for the Advancement of Military Medicine [W81XWH-07-2-0067, W81XWH-11-2-0174]; Department of Defense [W81XWH-07-2-0067, W81XWH-11-2-0174] FX These studies were supported by the cooperative agreements (W81XWH-07-2-0067 and W81XWH-11-2-0174) between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the Department of Defense. NR 38 TC 1 Z9 1 U1 2 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0025-7974 EI 1536-5964 J9 MEDICINE JI Medicine (Baltimore) PD AUG PY 2016 VL 95 IS 32 AR e4346 DI 10.1097/MD.0000000000004346 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA DU5IX UT WOS:000382246500011 PM 27512845 ER PT J AU Schauer, SG Varney, SM Aden, JK Bebarta, VS AF Schauer, Steven G. Varney, Shawn M. Aden, James K. Bebarta, Vikhyat S. TI Patient Perceptions of Oseltamivir for the Treatment of Influenza SO SOUTHERN MEDICAL JOURNAL LA English DT Article DE adverse effects; influenza; oseltamivir; perceptions ID UNITED-STATES; SEASONAL INFLUENZA; SATISFACTION; CARE; MORTALITY; THERAPY; ONTARIO; DISEASE; CANADA; IMPACT AB Objectives Oseltamivir (Tamiflu) is approved by the Food and Drug Administration and is advertised for the treatment of influenza types A and B. Patient perceptions of its efficacy have not been adequately studied. Recent systematic reviews have called the benefits of this drug into question relative to the cost and adverse effect profile. We hypothesized that most people would be unaware of the efficacy, cost, or adverse effect profile of the drug. Our objective was to determine patient perceptions of efficacy, cost, and adverse effect profile of oseltamivir for the treatment of influenza. Methods This was a cross-sectional, multiple-choice, open-response survey of adult patients and adult caregivers of pediatric patients who presented to the emergency department (ED) with flu-like symptoms. Flu-like symptoms were defined as any respiratory symptom plus fever or body aches. The study took place during the 2014-2015 flu season at a rural ED. We analyzed the data, with descriptive statistics reported as frequencies/percentages for categorical data. Survey data collected as Likert scale data were summarized using mean, median, and mode. Results During the 4-month period, 70 surveys were completed. A total of 67% of the participants were women, with 84% younger than 40 years. Subjects younger than 40 years were more likely to have seen advertising for oseltamivir (31% vs 0%, P = 0.04). Less than half reported having received the flu vaccine that year. Most reported that oseltamivir was an effective treatment for the flu. Most overstated the perceived efficacy of oseltamivir. Most were not willing to take the medication if it had adverse effects, with the most deterring adverse effects being potential kidney and liver injury. Conclusions In our study most patients reported overly positive expectations for the efficacy of oseltamivir for treating influenza. Most reported that commonly listed adverse effects would deter their use of the medication. C1 US Army Inst Surg Res, San Antonio, TX USA. San Antonio Mil Med Ctr, Joint Base San Antonio Ft Sam Houston, San Antonio, TX USA. Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. Univ Colorado, Aurora, CO USA. RP Schauer, SG (reprint author), JBSA Ft Sam Houston, 3698 Chambers Pass, San Antonio, TX 78234 USA. EM Steven.g.schauer.mil@mail.mil RI bebarta, vikhyat/K-3476-2015 NR 20 TC 0 Z9 0 U1 5 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0038-4348 EI 1541-8243 J9 SOUTH MED J JI South.Med.J. PD AUG PY 2016 VL 109 IS 8 BP 477 EP 480 DI 10.14423/SMJ.0000000000000499 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA DU8RD UT WOS:000382480500011 PM 27490658 ER PT J AU Hernandez, ED Bassett, AW Sadler, JM La Scala, JJ Stanzione, JF AF Hernandez, Eric D. Bassett, Alexander W. Sadler, Joshua M. La Scala, John J. Stanzione, Joseph F., III TI Synthesis and Characterization of Bio-based Epoxy Resins Derived from Vanillyl Alcohol SO ACS SUSTAINABLE CHEMISTRY & ENGINEERING LA English DT Article DE Resins; BPA alternatives; Structure-property relations; Thermosets; Lignin ID BISPHENOL-A; RENEWABLE RESOURCES; DIGLYCIDYL ETHER; ITACONIC ACID; LIGNIN; THERMOSETS; FUNCTIONALIZATION; PYROLYSIS; ANHYDRIDE; OXIDATION AB Vanillyl alcohol, a lignin derived aromatic diol, is a potential platform chemical for the production of renewable epoxy thermosets. A bio-based bisphenolic analogue, bisguaiacol (BG), was synthesized via electrophilic aromatic condensation of vanillyl alcohol and guaiacol, from which diglycidyl ether of BG (DGEBG) was prepared. In addition, three single aromatic diglycidyl ethers were synthesized from vanillyl alcohol (DGEVA), gastrodigenin (DGEGD), and hydroquinone (DGEHQ). All epoxies were characterized via H-1 NMR, C-13 NMR, FTIR, MS, and GPC. Dynamic mechanical analyses of the epoxies by themselves or blended with a commercial epoxy resin and cured with a diamine were conducted to determine the effect of the methoxy and methylene moieties on polymer properties. The thermomechanical results indicate that the methoxy lowers the glass transition temperature (T-g) yet increases the glassy storage modulus at 25 degrees C, while the methylene spacer between the aromatic ring and the epoxide further lowers the T-g in cured epoxy-amine systems. C1 [Hernandez, Eric D.; Bassett, Alexander W.; Stanzione, Joseph F., III] Rowan Univ, Dept Chem Engn, 201 Mullica Hill Rd, Glassboro, NJ 08028 USA. [Sadler, Joshua M.; La Scala, John J.] US Army Res Lab, RDRL WM, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. RP Stanzione, JF (reprint author), Rowan Univ, Dept Chem Engn, 201 Mullica Hill Rd, Glassboro, NJ 08028 USA. EM stanzione@rowan.edu FU Army Research Laboratory through the Cooperative Agreement [W911NF-14-2-0086]; SEED Funding Program at Rowan University FX We would like to acknowledge financial support of the Army Research Laboratory through the Cooperative Agreement W911NF-14-2-0086 as well as the SEED Funding Program at Rowan University. We would also like to thank Professor Jonathan Foglein of the Chemistry Department at Rowan University for his aid in the use of the NMR spectrometer. In addition, we would like thank the University of Delaware for use of their mass spectrometry facilities. NR 65 TC 5 Z9 5 U1 33 U2 37 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2168-0485 J9 ACS SUSTAIN CHEM ENG JI ACS Sustain. Chem. Eng. PD AUG PY 2016 VL 4 IS 8 BP 4328 EP 4339 DI 10.1021/acssuschemeng.6b00835 PG 12 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Chemical SC Chemistry; Science & Technology - Other Topics; Engineering GA DS6CR UT WOS:000380869800031 ER PT J AU Gremillion, GM Humbert, JS AF Gremillion, Gregory M. Humbert, J. Sean TI Disturbance Rejection with Distributed Acceleration Sensing for Small Unmanned Aircraft Systems SO AIAA JOURNAL LA English DT Article ID CAMPANIFORM SENSILLA; HALTERES; SENSORS; DESIGN; STRAIN AB Rapid sensing of body motions is critical to stabilizing a flight vehicle in the presence of exogenous disturbances as well as providing high-performance tracking of desired control commands. This bandwidth requirement becomes more stringent as vehicle scale decreases. Many flying insects employ distributed networks of acceleration-sensitive sensors to provide information about body egomotion to rapidly detect forces and torques. In this work, a method for rapid sensing of force and torque using a distributed array of accelerometers, arbitrarily placed and rigidly affixed to a vehicle airframe, was developed. Simulations of the sensor array were performed to quantify the effects of sensor noise, sensor position error, and sensor number on acceleration state estimates. A hardware implementation of this distributed sensor array was designed and integrated into the avionics of a small quadrotor vehicle. The response of the array to induced acceleration stimuli was characterized. A linear state estimation matrix was derived from the calibration to directly estimate the total forces and torques exerted on the airframe. A force-adaptive control law utilizing the force and torque estimates provided by the sensor network was implemented to improve tracking of reference states while rejecting exogenous force and torque disturbances. Successful rejection of disturbances in the form of internal actuator variation and external wind gusts was demonstrated on the quadrotor vehicle in flight. C1 [Gremillion, Gregory M.] US Army, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA. [Gremillion, Gregory M.] US Army, Dept Aerosp Engn, Res Lab, Adelphi, MD 20783 USA. [Gremillion, Gregory M.] Univ Maryland, College Pk, MD 20742 USA. [Humbert, J. Sean] Univ Maryland, Dept Aerosp Engn, College Pk, MD 20742 USA. RP Gremillion, GM (reprint author), US Army, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA.; Gremillion, GM (reprint author), US Army, Dept Aerosp Engn, Res Lab, Adelphi, MD 20783 USA.; Gremillion, GM (reprint author), Univ Maryland, College Pk, MD 20742 USA. EM gmgrem@umd.edu; humbert@umd.edu FU U.S. Army Research Laboratory Micro-Autonomous Systems and Technology-Collaborative Technology Alliance; U.S. Air Force Office of Scientific Research [CoE FA9550-14-1-0398] FX This work was supported by the U.S. Army Research Laboratory Micro-Autonomous Systems and Technology-Collaborative Technology Alliance and U.S. Air Force Office of Scientific Research CoE FA9550-14-1-0398. NR 30 TC 0 Z9 0 U1 7 U2 7 PU AMER INST AERONAUTICS ASTRONAUTICS PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0001-1452 EI 1533-385X J9 AIAA J JI AIAA J. PD AUG PY 2016 VL 54 IS 8 BP 2233 EP 2246 DI 10.2514/1.J054408 PG 14 WC Engineering, Aerospace SC Engineering GA DT2EI UT WOS:000381293200004 ER PT J AU Jenkins, EK Lee-Fowler, TM Angle, TC Behrend, EN Moore, GE AF Jenkins, Eileen K. Lee-Fowler, Tekla M. Angle, T. Craig Behrend, Ellen N. Moore, George E. TI Effects of oral administration of metronidazole and doxycycline on olfactory capabilities of explosives detection dogs SO AMERICAN JOURNAL OF VETERINARY RESEARCH LA English DT Article ID DRUG-INDUCED TASTE; SMELL; DYSFUNCTION; DISORDERS; ANOSMIA AB OBJECTIVE To determine effects of oral administration of metronidazole or doxycycline on olfactory function in explosives detection (ED) dogs. ANIMALS 18 ED dogs. PROCEDURES Metronidazole was administered (25 mg/kg, PO, q 12 h for 10 days); the day prior to drug administration was designated day 0. Odor detection threshold was measured with a standard scent wheel and 3 explosives (ammonium nitrate, trinitrotoluene, and smokeless powder; weight, 1 to 500 mg) on days 0, 5, and 10. Lowest repeatable weight detected was recorded as the detection threshold. There was a 10-day washout period, and doxycycline was administered (5 mg/kg, PO, q 12 h for 10 days) and the testing protocol repeated. Degradation changes in the detection threshold for dogs were assessed. RESULTS Metronidazole administration resulted in degradation of the detection threshold for 2 of 3 explosives (ammonium nitrate and trinitrotoluene). Nine of 18 dogs had a degradation of performance in response to 1 or more explosives (5 dogs had degradation on day 5 or 10 and 4 dogs had degradation on both days 5 and 10). There was no significant degradation during doxycycline administration. CONCLUSIONS AND CLINICAL RELEVANCE Degradation in the ability to detect odors of explosives during metronidazole administration at 25 mg/kg, PO, every 12 hours, indicated a potential risk for use of this drug in ED dogs. Additional studies will be needed to determine whether lower doses would have the same effect. Doxycycline administered at the tested dose appeared to be safe for use in ED dogs. (Am J Vet Res 2016;77:906-912) C1 [Jenkins, Eileen K.; Lee-Fowler, Tekla M.; Behrend, Ellen N.] Auburn Univ, Coll Vet Med, Dept Clin Sci, Auburn, AL 36489 USA. [Angle, T. Craig] Auburn Univ, Coll Vet Med, Canine Performance Sci Program, Auburn, AL 36489 USA. [Moore, George E.] Purdue Univ, Coll Vet Med, Dept Comparat Pathobiol, W Lafayette, IN 47907 USA. [Jenkins, Eileen K.] 248th Med Detachment Vet Serv Support, Ft Bragg, NC 28310 USA. RP Lee-Fowler, TM (reprint author), Auburn Univ, Coll Vet Med, Dept Clin Sci, Auburn, AL 36489 USA. EM tml0005@auburn.edu FU Interdepartmental Research Grants Program; Scott-Richey Research Center, College of Veterinary Medicine; Animal Health Disease Research Intramural Grants Program, Auburn University FX Supported in part by the Interdepartmental Research Grants Program; the Scott-Richey Research Center, College of Veterinary Medicine; and the Animal Health Disease Research Intramural Grants Program, Auburn University. NR 27 TC 0 Z9 0 U1 11 U2 12 PU AMER VETERINARY MEDICAL ASSOC PI SCHAUMBURG PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 USA SN 0002-9645 EI 1943-5681 J9 AM J VET RES JI Am. J. Vet. Res. PD AUG PY 2016 VL 77 IS 8 BP 906 EP 912 PG 7 WC Veterinary Sciences SC Veterinary Sciences GA DS6WV UT WOS:000380924800025 PM 27463556 ER PT J AU McGann, P Snesrud, E Maybank, R Corey, B Ong, AC Clifford, R Hinkle, M Whitman, T Lesho, E Schaecher, KE AF McGann, Patrick Snesrud, Erik Maybank, Rosslyn Corey, Brendan Ong, Ana C. Clifford, Robert Hinkle, Mary Whitman, Timothy Lesho, Emil Schaecher, Kurt E. TI Escherichia coli Harboring mcr-1 and bla(CTX-M) on a Novel IncF Plasmid: First Report of mcr-1 in the United States (vol 60, pg 4420, 2016) SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Correction C1 [McGann, Patrick; Snesrud, Erik; Maybank, Rosslyn; Corey, Brendan; Ong, Ana C.; Clifford, Robert; Hinkle, Mary; Lesho, Emil] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA. [Whitman, Timothy] Walter Reed Natl Mil Med Ctr, Dept Infect Dis, Bethesda, MD USA. [Schaecher, Kurt E.] Walter Reed Natl Mil Med Ctr, Dept Pathol, Bethesda, MD USA. RP McGann, P (reprint author), Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA. NR 1 TC 0 Z9 0 U1 8 U2 8 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD AUG PY 2016 VL 60 IS 8 BP 5107 EP 5107 DI 10.1128/AAC.01353-16 PG 1 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA DS5AJ UT WOS:000380792600095 PM 27451440 ER PT J AU Shiels, SM Cobb, RR Bedigrew, KM Ritter, G Kirk, JF Kimbler, A Baker, IF Wenke, JC AF Shiels, S. M. Cobb, R. R. Bedigrew, K. M. Ritter, G. Kirk, J. F. Kimbler, A. Baker, I. Finger Wenke, J. C. TI Antibiotic-loaded bone void filler accelerates healing in a femoral condylar rat model SO BONE & JOINT JOURNAL LA English DT Article ID SURGICAL-SITE INFECTIONS; ORTHOPEDIC-SURGERY; VANCOMYCIN POWDER; MATRIX; COMPLICATIONS; DELIVERY; DEFECTS; GRAFT; COST; RECONSTRUCTION AB Aims Demineralised bone matrix ( DBM) is rarely used for the local delivery of prophylactic antibiotics. Our aim, in this study, was to show that a graft with a bioactive glass and DBM combination, which is currently available for clinical use, can be loaded with tobramycin and release levels of antibiotic greater than the minimum inhibitory concentration for Staphylococcus aureus without interfering with the bone healing properties of the graft, thus protecting the graft and surrounding tissues from infection. Materials and Methods Antibiotic was loaded into a graft and subsequently evaluated for drug elution kinetics and the inhibition of bacterial growth. A rat femoral condylar plug model was used to determine the effect of the graft, loaded with antibiotic, on bone healing. Results We found that tobramycin loaded into a graft composed of bioglass and DBM eluted antibiotic above the minimum inhibitory concentration for three days in vitro. It was also found that the antibiotic loaded into the graft produced no adverse effects on the bone healing properties of the DBM at a lower level of antibiotic. Conclusion This antibiotic-loaded bone void filler may represent a promising option for the delivery of local antibiotics in orthopaedic surgery. C1 [Shiels, S. M.; Cobb, R. R.; Bedigrew, K. M.; Ritter, G.; Kirk, J. F.; Kimbler, A.; Baker, I. Finger; Wenke, J. C.] US Army, Inst Surg Res, Jbsa Ft Sam Houston, TX USA. [Shiels, S. M.; Bedigrew, K. M.; Wenke, J. C.] US Army, Inst Surg Res, Extrem Trauma & Regenerat Med, 3698 Chambers Pass,Bldg 3611, Jbsa Ft Sam Houston, TX USA. [Cobb, R. R.; Ritter, G.; Kirk, J. F.; Kimbler, A.; Baker, I. Finger] Nanotherapeut Inc, 13859 Progress Blvd, Alachua, FL 32615 USA. RP Shiels, SM (reprint author), US Army, Inst Surg Res, Jbsa Ft Sam Houston, TX USA.; Shiels, SM (reprint author), US Army, Inst Surg Res, Extrem Trauma & Regenerat Med, 3698 Chambers Pass,Bldg 3611, Jbsa Ft Sam Houston, TX USA. EM stefanie.m.shiels.vol@mail.mil FU DOD [W81XWH-11-1-0661] FX Authors RRC, GR, JFK, AK and IF are employees of Nanotherapeutics Inc. This work was supported by DOD contract W81XWH-11-1-0661. SMS is a program participant of the Oak Ridge Institute for Science and Education. NR 30 TC 0 Z9 0 U1 4 U2 4 PU BRITISH EDITORIAL SOC BONE JOINT SURGERY PI LONDON PA 22 BUCKINGHAM STREET, LONDON WC2N 6ET, ENGLAND SN 2049-4394 J9 BONE JOINT J JI Bone Joint J. PD AUG PY 2016 VL 98B IS 8 BP 1126 EP 1131 DI 10.1302/0301-620X.98B837634 PG 6 WC Orthopedics; Surgery SC Orthopedics; Surgery GA DS7HD UT WOS:000380953100020 PM 27482028 ER PT J AU Cole, DM Hopkins, MA AF Cole, David M. Hopkins, Mark A. TI The contact properties of naturally occurring geologic materials: experimental observations SO GRANULAR MATTER LA English DT Article DE Granular media; Geologic materials; Contact mechanics; Contact experiments ID GRAIN-SCALE EXPERIMENTS; SURFACE-ROUGHNESS; ELASTIC CONTACT; FINITE FRICTION; HERTZ CONTACT; MECHANICS; INTERFACE AB The discrete element method (DEM) is seeing widespread use in geotechnical applications and it is generally acknowledged that the validity of DEM simulations involving this class of materials depends critically on employing realistic contact laws. To support the development of such contact laws for common naturally occurring materials, we have conducted grain-to-grain contact experiments on several quartz sands, magnesite (limestone), crushed and ball-milled gneiss and ooids (precipitated calcium carbonate spheroids) and two reference materials (glass beads and the synthetic Delrin). Here we present the results of normal and shear contact experiments on these materials, with emphasis on the range of behavior encountered and aspects of behavior that deviate from current thinking on the topic. The development of contact laws based on the results presented herein, macroscopic frictional sliding and the implementation of the contact laws in DEM simulations are addressed in separate publications. The present experiments primarily examined the cyclic loading response, which allowed for a precise determination of normal and shear contact stiffness and loss compliances. Deformation generally consisted of elastic, anelastic and permanent components and the latter could be observed in shear prior to macroscopic sliding. Normal and shear stiffness ranged from 0.2-2.0 to 0.1-1.0 MN m(-1), respectively although the ratio of shear to normal stiffness for specific materials varied from 0.3 to approximate to 1. Frictional loss was observed to varying degrees in all of the contacts examined and internal friction in shear was found to be constant prior to the onset of permanent deformation. Internal friction ranged from barely perceptible to 0.1 for normal contacts and from 0.02 to 0.3 in shear. The modeling implications of the findings are examined as well. C1 [Cole, David M.; Hopkins, Mark A.] ERDC CRREL RET, 72 Lyme Rd, Hanover, NH 03755 USA. RP Cole, DM (reprint author), ERDC CRREL RET, 72 Lyme Rd, Hanover, NH 03755 USA. EM David.mcg.Cole@gmail.com; markahopkins@icloud.com FU ERDC Military Engineering Basic Research program FX The authors gratefully acknowledge the ERDC Military Engineering Basic Research program for supporting this work. We thank Dr. John Peters for many helpful discussions on granular media behavior. We especially recognize the following engineering support personnel at ERDC-CRREL who made many important contributions to the hardware and software designs that assured the success of this work: Douglas Punt, William Burch, Christopher Williams and John Gagnon. NR 37 TC 1 Z9 1 U1 10 U2 11 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1434-5021 EI 1434-7636 J9 GRANUL MATTER JI Granul. Matter PD AUG PY 2016 VL 18 IS 3 AR 62 DI 10.1007/s10035-016-0658-5 PG 16 WC Materials Science, Multidisciplinary; Mechanics; Physics, Applied SC Materials Science; Mechanics; Physics GA DT0CC UT WOS:000381149100029 ER PT J AU Hajifathalian, K Howell, G Wambeke, BW Hsiang, SM Liu, M AF Hajifathalian, Kiarash Howell, Gregory Wambeke, Brad W. Hsiang, Simon M. Liu, Min TI "Oops" Simulation: Cost-Benefits Trade-Off Analysis of Reliable Planning for Construction Activities SO JOURNAL OF CONSTRUCTION ENGINEERING AND MANAGEMENT LA English DT Article DE Planning; Cost of project; Productivity; Performance reliability; Computer aided simulation; Labor and personnel issues AB The Oops Game explores the question, how much should be invested in planning? The simulation offers the opportunity to reduce the risk of an Oops by collecting more information or to go ahead and make the choice with the information at hand. There are two extreme strategies. Nothing is invested in planning in the so-called Guts-ball approach, but this increases the likelihood that an Oops will occur and thus increases the cost to complete the project. The second strategy is to invest in planning before attempting to build. This will increase the cost of planning upfront, but may reduce the risk and cost of an Oops in building. In reality, the cost and value of planning depends on the complexity level of the project, the amount of uncertainty that we need to deal with it, and the cost of an Oops. We used computer simulation to show how the value of planning is sensitive to those factors. The results showed that the project with the reliable planning strategy had a 35% higher productivity and a cost-benefit ratio of 13:1. The contribution to the body of knowledge of The Oops Game lies in providing a simple and effective means to show the value of planning to construction practitioners and students. The findings from this research fill in the gap of knowledge in quantifying the value of plan under different circumstance for construction projects. C1 [Hajifathalian, Kiarash; Liu, Min] North Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA. [Howell, Gregory] Lean Construct Inst, 101 Alpine Dr,Box 1003, Ketchum, ID 83340 USA. [Wambeke, Brad W.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. [Hsiang, Simon M.] Univ N Carolina, Dept Syst Engn & Engn Management, Charlotte, NC 28223 USA. RP Liu, M (reprint author), North Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA. EM khajifa@ncsu.edu; ghowell@leanconstruction.org; bwwambek@ncsu.edu; shsiang1@uncc.edu; min_liu@ncsu.edu NR 21 TC 0 Z9 0 U1 11 U2 11 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9364 EI 1943-7862 J9 J CONSTR ENG M JI J. Constr. Eng. Manage. PD AUG PY 2016 VL 142 IS 8 AR 04016030 DI 10.1061/(ASCE)CO.1943-7862.0001135 PG 8 WC Construction & Building Technology; Engineering, Industrial; Engineering, Civil SC Construction & Building Technology; Engineering GA DS8NL UT WOS:000381040000007 ER PT J AU Ashtiani, RS Pullen, AB Hammons, MI AF Ashtiani, Reza S. Pullen, Aaron B. Hammons, Michael I. TI Comparative Study of Water-Blasting Equipment for Airfield Surface Decontamination SO JOURNAL OF MATERIALS IN CIVIL ENGINEERING LA English DT Article DE Runway friction; Runway rubber removal; Runway maintenance; Runway skid resistance; Airfield surface decontamination AB Runway rubber removal is a maintenance function employed to ensure safe landing areas for aviation operations. Rubber deposits accumulate on runway areas where aircraft tires touchdown and braking occurs. This tire-rubber build-up occludes pavement microtexture and macrotexture, causing a significant loss in available skid resistance during wet conditions. Reduction of available pavement microtexture in a wet environment prevents the development of adhesional friction, which can result in viscous hydroplaning. Reduction of pavement macrotexture prevents the removal of bulk water from the tire-pavement contact area and also prevents the development of the hysteresis frictional component. To restore friction to safe levels for aircraft operations, rubber must be periodically removed. Several techniques for rubber removal are available. Water-blasting is a proven surface decontamination technique which employs the use of high-pressure or ultra-high-pressure water (UHPW) to blast rubber deposits from the runway surface. This effort provides a performance-based comparison between three commercially available UHPW water-blasting systems. The evaluation was conducted on an ungrooved portland cement concrete (PCC) runway with heavy rubber contamination along the touchdown and breaking zones. Several types of testing equipment such as a circular track meter (CTM) and dynamic friction tester (DFT) were used to characterize the surface properties of the runway before and after rubber removal. The measurements were used for statistical pairwise comparative analysis of International Friction Index (IFI), speed constant and mean profile depth (MPD). Treatment effect analysis of premeasured and postmeasured data revealed that UHPW systems improved the surface texture properties by at least 40% regardless of the decontamination equipment. C1 [Ashtiani, Reza S.] Univ Texas El Paso, Dept Civil Engn, 500 W Univ Ave, El Paso, TX 79902 USA. [Pullen, Aaron B.] Appl Res Associates Inc, 104 Res Rd,Bldg 9742, Tyndall AFB, FL 32403 USA. [Hammons, Michael I.] US Army Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. RP Ashtiani, RS (reprint author), Univ Texas El Paso, Dept Civil Engn, 500 W Univ Ave, El Paso, TX 79902 USA. EM reza@utep.edu; apullen@ara.com; michael.i.hammons@usace.army.mil NR 11 TC 0 Z9 0 U1 8 U2 8 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0899-1561 EI 1943-5533 J9 J MATER CIVIL ENG JI J. Mater. Civ. Eng. PD AUG PY 2016 VL 28 IS 8 AR 04016053 DI 10.1061/(ASCE)MT.1943-5533.0001530 PG 10 WC Construction & Building Technology; Engineering, Civil; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA DS8SB UT WOS:000381052200003 ER PT J AU Vincenti, MA de Ceglia, D Scalora, M AF Vincenti, M. A. de Ceglia, D. Scalora, Michael TI Anomalous nonlinear absorption in epsilon-near-zero materials: optical limiting and all-optical control SO OPTICS LETTERS LA English DT Article ID 2ND-HARMONIC GENERATION; PERMITTIVITY; PULSES; MEDIA AB We investigate nonlinear absorption in films of epsilon-near-zero materials. The combination of large local electric fields at the fundamental frequency and material losses at the harmonic frequencies induce unusual intensity-dependent phenomena. We predict that the second-order nonlinearity of a low-damping, epsilon-near-zero slab produces an optical limiting effect that mimics a two-photon absorption process. Anomalous absorption profiles that depend on low permittivity values at the pump frequency are also predicted for third-order nonlinearities. These findings suggest new opportunities for all-optical light control and novel ways to design reconfigurable and tunable nonlinear devices. (C) 2016 Optical Society of America C1 [Vincenti, M. A.; de Ceglia, D.] CNR, AMRDEC, Charles M Bowden Res Lab, Redstone Arsenal, AL 35898 USA. [Scalora, Michael] US Army RDECOM, Charles M Bowden Res Lab, AMRDEC, Redstone Arsenal, AL 35898 USA. RP Vincenti, MA (reprint author), CNR, AMRDEC, Charles M Bowden Res Lab, Redstone Arsenal, AL 35898 USA. EM vincentiantonella@gmail.com NR 33 TC 0 Z9 0 U1 12 U2 12 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 EI 1539-4794 J9 OPT LETT JI Opt. Lett. PD AUG 1 PY 2016 VL 41 IS 15 BP 3611 EP 3614 DI 10.1364/OL.41.003611 PG 4 WC Optics SC Optics GA DS8DV UT WOS:000381014400056 PM 27472631 ER PT J AU Scherpbier, HJ Terpstra, V Pajkrt, D Puthakanit, T Ananworanich, J Foster, C Weerman, MV Deurloo, EE van der Valk, M Kuijpers, TW Koot, BG AF Scherpbier, Henriette J. Terpstra, Valeska Pajkrt, Dasja Puthakanit, Thanyawee Ananworanich, Jintanat Foster, Caroline Weerman, Marius van den Bergh Deurloo, Eline E. van der Valk, Marc Kuijpers, Taco W. Koot, Bart G. TI Noncirrhotic Portal Hypertension in Perinatally HIV-infected Adolescents Treated With Didanosine-containing Antiretroviral Regimens in Childhood SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE portal hypertension; HIV; didanosine; children ID LIVER-DISEASE; HEPATITIS-C; CHILDREN; HEPATOTOXICITY; EXPOSURE; THERAPY AB Background : Noncirrhotic portal hypertension (NCPH) has been reported in HIV-infected adults. Antiretroviral drugs, as well as genetic and thrombophilic predisposition, have been suggested as possible etiologic factors. Methods: Clinical data were collected from 6 HIV-infected patients attending the Infectious Diseases Departments at respectively Emma Children's Hospital Academic Medical Centre in Amsterdam, The Thai Red Cross AIDS Research Centre, Bangkok, Imperial College Healthcare NHS Trust, London who were diagnosed with NCPH. All underwent extensive blood analysis, liver ultrasound, liver elastography, esophagogastroduodenoscopy and percutaneous needle liver biopsy for histological evaluation. Results: We describe 6 perinatally HIV-infected adolescents, all female, who developed NCPH after prolonged exposure during childhood to a didanosine-containing antiretroviral regimen. Histology and electron microscopy showed periportal fibrosis and mitochondrial damage as key findings in their liver biopsies. One of these 6 patients required surgical intervention, the remainder have been managed conservatively to date. Conclusions: Thus, symptomatic NCPH may present in adolescence after perinatally acquired HIV-1 infection. In this case series, risk factors included female sex and prolonged exposure to antiretroviral regimens that included the nucleoside-analogue didanosine in childhood. C1 [Scherpbier, Henriette J.; Pajkrt, Dasja; Kuijpers, Taco W.] AMC, Emma Childrens Hosp, Dept Pediat Hematol Immunol & Infect Dis, Amsterdam, Netherlands. [Terpstra, Valeska; Weerman, Marius van den Bergh] AMC, Emma Childrens Hosp, Dept Pathol, Amsterdam, Netherlands. [Terpstra, Valeska] MCH Bronovo Hosp, Dept Pathol, The Hague, Netherlands. [Puthakanit, Thanyawee] Chulalongkorn Univ, Fac Med, Bangkok, Thailand. [Puthakanit, Thanyawee] Thai Red Cross AIDS Res Ctr, HIVNAT, Bangkok, Thailand. [Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Foster, Caroline] Imperial Coll Healthcare NHS Trust, Dept Infect Dis, London, England. [Deurloo, Eline E.] AMC, Dept Radiodiagnost, Amsterdam, Netherlands. [van der Valk, Marc] AMC, Infect Dis, Amsterdam, Netherlands. [Koot, Bart G.] AMC, Emma Childrens Hosp, Dept Pediat Gastroenterol, Amsterdam, Netherlands. RP Scherpbier, HJ (reprint author), Univ Amsterdam, Acad Med Ctr, Emma Childrens Hosp, Dept Pediat Hematol Immunol & Infect Dis, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands. EM h.j.scherpbier@amc.uva.nl FU ViiV Healthcare; Gilead; Pfizer; Johnson Johnson; ViiV; MSD; AbbVie; BMS FX T.P. got research funding from ViiV Healthcare; J.A. has received honorarium for advisory participation from ViiV Healthcare, Merck, Roche and Tetralogic; C.F. has received research support from Gilead, Pfizer and consultancy fees by Johnson & Johnson and ViiV; M.v.d.V. has received research support from Johnson & Johnson, MSD and consultancy fees from AbbVie, BMS, Gilead, Johnson & Johnson and MSD. The other authors have no conflicts of interest or funding to disclose. NR 31 TC 0 Z9 0 U1 2 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0891-3668 EI 1532-0987 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD AUG PY 2016 VL 35 IS 8 BP E248 EP E252 DI 10.1097/INF.0000000000001202 PG 5 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA DS4MK UT WOS:000380755000002 PM 27167116 ER PT J AU Salhanick, MA Sams, VG Pidcoke, HF Fedyk, CG Scherer, MR Dubick, MA Dent, DL Cap, AP Schwacha, MG AF Salhanick, Marc A. Sams, Valere G. Pidcoke, Heather F. Fedyk, Chriselda G. Scherer, Michael R. Dubick, Michael A. Dent, Daniel L. Cap, Andrew P. Schwacha, Martin G. TI Shed Pleural Blood from Traumatic Hemothorax Contains Elevated Levels of Pro-Inflammatory Cytokines SO SHOCK LA English DT Article DE Autotransfusion; hemothorax; immune; inflammation; pleural blood; trauma ID TOTAL KNEE ARTHROPLASTY; FRESH WHOLE-BLOOD; MASSIVE TRANSFUSION; AUTOLOGOUS BLOOD; SALVAGED BLOOD; DRAIN BLOOD; AUTOTRANSFUSION; PLASMA; COAGULATION; PLATELETS AB Purpose:The autotransfusion of unwashed (or unprocessed) shed hemothorax blood (USHB) in trauma patients is widely assumed to be beneficial; however, the inflammatory potential of shed pleural blood has not been thoroughly studied. Since previous studies have documented marked changes in coagulation function of shed pleural blood, we hypothesized that its level of inflammatory cytokines would be elevated.Methods:A prospective observational study of trauma patients in whom cytokine levels from USHB were compared to venous samples from healthy volunteers was conducted. Differences between the cytokine content of patient-derived samples were compared to those from healthy subjects.Results:There was a statistically significant increase in pro-inflammatory cytokines (IL-6, IL-8, TNF, GM-CSF), a pro-inflammatory Th-1 cytokine (IFN), and anti-inflammatory Th-2 cytokines (IL-4 and IL-10) in shed pleural blood over four hours when compared with samples from healthy controls (P<0.05). Cytokine levels in USHB are approximately 10- to 100-fold higher compared with healthy control venous samples.Conclusions:USHB, even collected within the accepted four-hour window, contains significantly elevated cytokine levels, suggesting the potential for deleterious effects from autotransfusion. Randomized trials are needed to determine the safety and efficacy of autotransfusion in trauma patients. C1 [Salhanick, Marc A.; Pidcoke, Heather F.; Dubick, Michael A.; Dent, Daniel L.; Cap, Andrew P.; Schwacha, Martin G.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, Div Trauma & Emergency Surg, San Antonio, TX 78229 USA. [Sams, Valere G.; Pidcoke, Heather F.; Fedyk, Chriselda G.; Scherer, Michael R.; Dubick, Michael A.; Cap, Andrew P.; Schwacha, Martin G.] US Army Inst Surg Res, Ft Sam Houston, TX USA. RP Schwacha, MG (reprint author), UT Hlth Sci Ctr San Antonio, Dept Surg, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA. EM Schwacha@uthscsa.edu FU US Army Medical Research and Materiel Command FX Source of support: US Army Medical Research and Materiel Command. NR 36 TC 1 Z9 1 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD AUG PY 2016 VL 46 IS 2 BP 144 EP 148 DI 10.1097/SHK.0000000000000609 PG 5 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA DS8NZ UT WOS:000381041400006 PM 26974427 ER PT J AU Lin, JS Smith, MA Benjamin, WH Kaminski, RW Wenzel, H Nahm, MH AF Lin, Jisheng Smith, Mark A. Benjamin, William H., Jr. Kaminski, Robert W. Wenzel, Heather Nahm, Moon H. TI Monoclonal Antibodies to Shigella Lipopolysaccharide Are Useful for Vaccine Production SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID FLEXNERI 2A; CONJUGATE VACCINES; CLONES BINDING; O-ANTIGENS; SONNEI; INFECTION; POLYSACCHARIDES; EPITOPES; DIARRHEA; TYPE-1 AB There is a significant need for an effective multivalent Shigella vaccine that targets the most prevalent serotypes. Most Shigella vaccines under development utilize serotype-specific lipopolysaccharides (LPSs) as a major component based on protection and epidemiological data. As vaccine formulations advance from monovalent to multivalent, assays and reagents need to be developed to accurately and reproducibly quantitate the amount of LPSs from multiple serotypes in the final product. To facilitate this effort, we produced 36 hybridomas that secrete monoclonal antibodies (MAbs) against the O antigen on the LPS from Shigella flexneri 2a, Shigella flexneri 3a, and Shigella sonnei. We used six of these monoclonal antibodies for an inhibition enzyme-linked immunosorbent assay (iELISA), measuring LPSs with high sensitivity and specificity. It was also demonstrated that the Shigella serotype-specific MAbs were useful for bacterial surface staining detected by flow cytometry. These MAbs are also useful for standardizing the serum bactericidal assay (SBA) for Shigella. Functional assays, such as the in vitro bactericidal assay, are necessary for vaccine evaluation and may serve as immunological correlates of immunity. An S. flexneri 2a-specific monoclonal antibody killed S. flexneri 2b isolates, suggesting that S. flexneri 2a LPS may induce cross-protection against S. flexneri 2b. Overall, the Shigella LPS-specific MAbs described have potential utility to the vaccine development community for assessing multivalent vaccine composition and as a reliable control for multiple immunoassays used to assess vaccine potency. C1 [Lin, Jisheng; Benjamin, William H., Jr.; Nahm, Moon H.] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA. [Smith, Mark A.; Kaminski, Robert W.] Walter Reed Army Inst Res, Subunit Enter Vaccines & Immunol, Washington, DC USA. [Wenzel, Heather] PATH, Washington, DC USA. RP Nahm, MH (reprint author), Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA. EM nahm@uab.edu RI Natarajan, Meena/J-9167-2012 OI Natarajan, Meena/0000-0001-5652-9681 FU PATH [GAT.I371-00374173-COL (05669-COL)] FX This work, including the efforts of Moon H. Nahm, was funded by PATH (GAT.I371-00374173-COL (05669-COL)). NR 27 TC 2 Z9 2 U1 4 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 EI 1556-679X J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD AUG PY 2016 VL 23 IS 8 BP 681 EP 688 DI 10.1128/CVI.00148-16 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA DS5NJ UT WOS:000380828700004 PM 27280622 ER PT J AU Natesan, M Jensen, SM Keasey, SL Kamata, T Kuehne, AI Stonier, SW Lutwama, JJ Lobel, L Dye, JM Ulrich, RG AF Natesan, Mohan Jensen, Stig M. Keasey, Sarah L. Kamata, Teddy Kuehne, Ana I. Stonier, Spencer W. Lutwama, Julius Julian Lobel, Leslie Dye, John M. Ulrich, Robert G. TI Human Survivors of Disease Outbreaks Caused by Ebola or Marburg Virus Exhibit Cross-Reactive and Long-Lived Antibody Responses SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID VIRION GLYCOPROTEINS; HEMORRHAGIC-FEVER; IMMUNE-RESPONSES; ZAIRE-EBOLAVIRUS; RISK-FACTORS; INFECTION; PROTEIN; GLYCOSYLATION; TRANSMISSION; MICROARRAYS AB A detailed understanding of serological immune responses to Ebola and Marburg virus infections will facilitate the development of effective diagnostic methods, therapeutics, and vaccines. We examined antibodies from Ebola or Marburg survivors 1 to 14 years after recovery from disease, by using a microarray that displayed recombinant nucleoprotein (NP), viral protein 40 (VP40), envelope glycoprotein (GP), and inactivated whole virions from six species of filoviruses. All three outbreak cohorts exhibited significant antibody responses to antigens from the original infecting species and a pattern of additional filoviruses that varied by outbreak. NP was the most cross-reactive antigen, while GP was the most specific. Antibodies from survivors of infections by Marburg marburgvirus (MARV) species were least cross-reactive, while those from survivors of infections by Sudan virus (SUDV) species exhibited the highest cross-reactivity. Based on results revealed by the protein microarray, persistent levels of antibodies to GP, NP, and VP40 were maintained for up to 14 years after infection, and survival of infection caused by one species imparted cross-reactive antibody responses to other filoviruses. C1 [Natesan, Mohan; Jensen, Stig M.; Keasey, Sarah L.; Kamata, Teddy; Ulrich, Robert G.] US Army, Med Res Inst Infect Dis, Mol & Translat Sci, Frederick, MD USA. [Kuehne, Ana I.; Stonier, Spencer W.; Dye, John M.; Ulrich, Robert G.] US Army, Med Res Inst Infect Dis, Div Virol, Frederick, MD USA. [Lutwama, Julius Julian] Uganda Virus Res Inst, Dept Arbovirol Emerging & Reemerging Infect, Entebbe, Uganda. [Lobel, Leslie] Ben Gurion Univ Negev, Fac Hlth Sci, Dept Microbiol Immunol & Genet, Beer Sheva, Israel. RP Natesan, M; Ulrich, RG (reprint author), US Army, Med Res Inst Infect Dis, Mol & Translat Sci, Frederick, MD USA.; Ulrich, RG (reprint author), US Army, Med Res Inst Infect Dis, Div Virol, Frederick, MD USA. EM mohan.natesan.ctr@mail.mil; robert.g.ulrich.civ@mail.mil FU NIAID [R01AI096215]; DTRA [CB3948] FX This work, including the efforts of Mohan Natesan and Robert G. Ulrich, was funded by NIAID (R01AI096215). This work, including the efforts of Robert G. Ulrich, was funded by DTRA (CB3948). NR 54 TC 1 Z9 1 U1 5 U2 9 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 EI 1556-679X J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD AUG PY 2016 VL 23 IS 8 BP 717 EP 724 DI 10.1128/CVI.00107-16 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA DS5NJ UT WOS:000380828700008 PM 27335383 ER PT J AU Wilk, JE Herrell, RK Carr, AL West, JC Wise, J Hoge, CW AF Wilk, Joshua E. Herrell, Richard K. Carr, Abby L. West, Joyce C. Wise, Joseph Hoge, Charles W. TI Diagnosis of PTSD by Army Behavioral Health Clinicians: Are Diagnoses Recorded in Electronic Health Records? SO PSYCHIATRIC SERVICES LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; IRAQ; AFGHANISTAN; COMBAT; CARE; PREVALENCE; DEPLOYMENT; ATTRITION; SOLDIERS; INTERNET AB Objective: The study sought to identify the extent to which posttraumatic stress disorder (PTSD) diagnoses are recorded in the electronic health record (EHR) in Army behavioral health clinics and to assess clinicians' reasons for not recording them and treatment factors associated with recording or not recording the diagnosis. Methods: A total of 543 Army mental health providers completed the anonymous, Web-based survey. Clinicians reported clinical data for 399 service member patients, of whom 110 (28%) had a reported PTSD diagnosis. Data were weighted to account for sampling design and nonresponses. Results: Of those given a diagnosis of PTSD by their clinician, 59% were reported to have the diagnosis recorded in the EHR, and 41% did not. The most common reason for not recording was reducing stigma or protecting the service member's career prospects. Psychiatrists were more likely than psychologists or social workers to record the diagnosis. Conclusions: Findings indicate that for many patients presenting with PTSD in Army behavioral health clinics at the time of the survey (2010), clinicians did not record a PTSD diagnosis in the EHR, often in an effort to reduce stigma. This pattern may exist for other diagnoses. Recent Army policy has provided guidance to clinicians on diagnostic recording practice. An important implication concerns the reliance on coded diagnoses in PTSD surveillance efforts by the U.S. Department of Defense (DoD). The problem of underestimated prevalence rates may be further compounded by overly narrow DoD surveillance definitions of PTSD. C1 [Wilk, Joshua E.; Herrell, Richard K.; Carr, Abby L.; Wise, Joseph; Hoge, Charles W.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. [West, Joyce C.] Amer Psychiat Assoc, Psychiat Res Network, Amer Psychiat Inst Res & Educ, Arlington, VA USA. RP Wilk, JE (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. EM joshua.e.wilk.civ@mail.mil FU Military Operational Medicine Research Area Directorate, U.S. Army Medical Research and Materiel Command, Ft. Detrick, Maryland; Takeda Pharmaceuticals; Forest Laboratories FX Funding for this project came from the Military Operational Medicine Research Area Directorate, U.S. Army Medical Research and Materiel Command, Ft. Detrick, Maryland. Material has been reviewed by the Walter Reed Army Institute of Research, with no objection to its presentation or publication. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Department of the Army or the U.S. Department of Defense.; Dr. West reports receipt of research support from Takeda Pharmaceuticals and Forest Laboratories. The other authors report no financial relationships with commercial interests. NR 14 TC 0 Z9 0 U1 4 U2 4 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 1075-2730 EI 1557-9700 J9 PSYCHIAT SERV JI Psychiatr. Serv. PD AUG 1 PY 2016 VL 67 IS 8 BP 878 EP 882 DI 10.1176/appi.ps.201500292 PG 5 WC Health Policy & Services; Public, Environmental & Occupational Health; Psychiatry SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Psychiatry GA DT7OC UT WOS:000381675100017 PM 26975516 ER PT J AU Orr, RM Pope, RP Knapik, JJ AF Orr, Robin M. Pope, Rodney P. Knapik, Joseph J. TI A Physical Training Framework for Reserve Personnel: A Rationalization and Recommendations SO STRENGTH AND CONDITIONING JOURNAL LA English DT Article DE military; part time; conditioning; fitness; injury prevention ID RISK-FACTORS; FITNESS TEST; NATIONAL-GUARD; IRAQI FREEDOM; DISEASE RISK; US-ARMY; PERFORMANCE; SOLDIERS; INJURY; RESISTANCE AB Reserve (part-time) army personnel typically perform occupational and operational tasks akin to those of their active-duty counterparts but may have lower fitness because of less physical training. As such, reserve military personnel may be at a greater risk of injury and have physical performance deficits. To improve fitness and performance, training guidelines suggest 3 d/wk aerobic training and 2 d/wk of strength training, although some days may include both. Among reserve military personnel away from their units, both general and occupationally oriented training could be tracked using computer applications and/or by evening training in groups, which may improve compliance and motivation. C1 [Orr, Robin M.; Pope, Rodney P.; Knapik, Joseph J.] Bond Univ, Tact Res Unit, Gold Coast, Australia. [Knapik, Joseph J.] Oak Ridge Inst Sci & Educ, US Army Res Inst Environm Med, Belcamp, MD USA. RP Orr, RM (reprint author), Bond Univ, Tact Res Unit, Gold Coast, Australia. EM rorr@bond.edu.au FU Defence Health Foundation FX Supported by a Defence Health Foundation grant. NR 53 TC 0 Z9 0 U1 2 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1524-1602 EI 1533-4295 J9 STRENGTH COND J JI Strength Cond. J. PD AUG PY 2016 VL 38 IS 4 BP 36 EP 41 DI 10.1519/SSC.0000000000000238 PG 6 WC Sport Sciences SC Sport Sciences GA DS4OZ UT WOS:000380761700004 ER PT J AU Prasitsuebsai, W Teeraananchai, S Singtoroj, T Truong, KH Ananworanich, J Do, VC Nguyen, LV Kosalaraksa, P Kurniati, N Sudjaritruk, T Chokephaibulkit, K Kerr, SJ Sohn, AH AF Prasitsuebsai, Wasana Teeraananchai, Sirinya Singtoroj, Thida Khanh Huu Truong Ananworanich, Jintanat Viet Chau Do Lam Van Nguyen Kosalaraksa, Pope Kurniati, Nia Sudjaritruk, Tavitiya Chokephaibulkit, Kulkanya Kerr, Stephen J. Sohn, Annette H. CA TASER-Pediat Study Grp TI Treatment Outcomes and Resistance Patterns of Children and Adolescents on Second-Line Antiretroviral Therapy in Asia SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE second-line antiretroviral therapy; children; adolescents; Asia; outcomes; resistance ID HIV-INFECTED CHILDREN; VISUAL ANALOG SCALE; VIROLOGICAL FAILURE; UGANDAN CHILDREN; ADHERENCE; REGIMENS; DATABASE; PREDICTORS; EFFICACY; PROGRAM AB Background:Data on pediatric treatment outcomes and drug resistance while on second-line antiretroviral therapy (ART) are needed to guide HIV care in resource-limited countries.Methods:HIV-infected children <18 years who were switched or switching to second-line ART after first-line failure were enrolled from 8 sites in Indonesia, Thailand, and Vietnam. Genotyping was performed at virologic failure (VF; HIV-RNA >1000 copies/mL). Cox proportional hazards regression was used to evaluate factors predicting VF.Results:Of 277 children, 41% were female. At second-line switch, age was 7.5 (5.3-10.3) years, CD4 count was 300 (146-562) cells per cubic millimeter, and percentage was 13 (7-20%); HIV-RNA was 5.0 (4.4-5.5) log(10) copies per milliliter. Second-line regimens contained lamivudine (90%), tenofovir (43%), zidovudine or abacavir (30%), lopinavir (LPV/r; 91%), and atazanavir (ATV; 7%). After 3.3 (1.8-5.3) years on second-line ART, CD4 was 763 (556-1060) cells per cubic millimeter and 26% (20-31%). VF occurred in 73 (27%), with an incidence of 7.25 per 100 person-years (95% confidence interval [CI]: 5.77 to 9.12). Resistance mutations in 50 of 73 children with available genotyping at first VF included M184V (56%), 1 thymidine analogue mutation (TAM; 40%), 4 TAMs (10%), Q151M (4%), any major LPV mutation (8%), 6 LPV mutations (2%), and any major ATV mutation (4%). Associations with VF included age >11 years (hazard ratio [HR] 4.06; 95% CI: 2.15 to 7.66) and HIV-RNA >5.0 log(10) copies per milliliter (HR 2.42; 95% CI: 1.27 to 4.59) at switch and were seen more commonly in children from Vietnam (HR 2.79; 95% CI: 1.55 to 5.02).Conclusions:One-fourth of children developed VF while on second-line ART. However, few developed major mutations to protease inhibitors. C1 [Prasitsuebsai, Wasana; Teeraananchai, Sirinya; Ananworanich, Jintanat; Kerr, Stephen J.] Thai Red Cross AIDS Res Ctr, HIV NAT, 104 Ratchadamri Rd, Bangkok 10330, Thailand. [Singtoroj, Thida; Sohn, Annette H.] TREAT Asia AmfAR, Bangkok, Thailand. [Khanh Huu Truong] Childrens Hosp 1, Dept Infect Dis, Ho Chi Minh City, Vietnam. [Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Walter Reed Army Inst Res, Bethesda, MD USA. [Viet Chau Do] Childrens Hosp 2, Dept Infect Dis, Ho Chi Minh City, Vietnam. [Lam Van Nguyen] Natl Hosp Pediat, Dept Infect Dis, Hanoi, Vietnam. [Kosalaraksa, Pope] Khon Kaen Univ, Div Infect Dis, Dept Pediat, Khon Kaen, Thailand. [Kurniati, Nia] Cipto Mangunkusumo Gen Hosp, Jakarta, Indonesia. [Sudjaritruk, Tavitiya] Chiang Mai Univ, Fac Med, Chiang Mai, Thailand. [Sudjaritruk, Tavitiya] Chiang Mai Univ, Res Inst Hlth Sci, Chiang Mai, Thailand. [Chokephaibulkit, Kulkanya] Mahidol Univ, Fac Med, Dept Pediat, Siriraj Hosp, Bangkok, Thailand. [Kerr, Stephen J.] Univ New South Wales, Kirby Inst, Sydney, NSW, Australia. [Kerr, Stephen J.] Univ Amsterdam, Amsterdam Inst Global Hlth & Dev, Dept Global Hlth, Acad Med Ctr, Amsterdam, Netherlands. RP Prasitsuebsai, W (reprint author), Thai Red Cross AIDS Res Ctr, HIV NAT, 104 Ratchadamri Rd, Bangkok 10330, Thailand. EM wasana.p@hivnat.org FU ViiV Healthcare; AIDS LIFE Association; US National Institutes of Health's National Institute of Allergy and Infectious Diseases; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Cancer Institute as part of the International Epidemiologic Databases to Evaluate AIDS (IeDEA) [U01AI069907] FX Supported by ViiV Healthcare, the AIDS LIFE Association, and the US National Institutes of Health's National Institute of Allergy and Infectious Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development, and National Cancer Institute as part of the International Epidemiologic Databases to Evaluate AIDS (IeDEA; U01AI069907). NR 31 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD AUG 1 PY 2016 VL 72 IS 4 BP 380 EP 386 DI 10.1097/QAI.0000000000000971 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA DS1PH UT WOS:000380367900006 PM 27355415 ER PT J AU Harbertson, J Hale, BR Watkins, EY Michael, NL Scott, PT AF Harbertson, Judith Hale, Braden R. Watkins, Eren Y. Michael, Nelson L. Scott, Paul T. TI Pre-deployment Alcohol Misuse Among Shipboard Active-Duty US Military Personnel SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID BINGE-DRINKING; AUDIT-C; COLLEGE-STUDENTS; PRIMARY-CARE; HEALTH; RISK; POPULATION; CONSUMPTION; PREVALENCE; DISORDERS AB Introduction: The burden of alcohol misuse is unknown among shipboard U.S. Navy and Marine Corps military personnel immediately prior to deployment and may be elevated. Methods: Anonymous survey data on hazardous, dependent, and binge alcohol misuse and involuntary drug consumption were collected during 2012-2014 among shipboard personnel within approximately 2 weeks of deployment. Using the Alcohol Use Disorders Identification Test Consumption (AUDIT-C), hazardous alcohol misuse was defined using two cut-point scoring criteria: (1) >= 3 for women and >= 4 for men; and (2) >= 4 for women and >= 5 for men; binge drinking as >= 4 drinks for women and >= 5 drinks for men on a typical day in past 30 days; and dependent alcohol misuse as an AUDIT-C score of >= 8. Demographic-and sex-stratified self-reported alcohol misuse prevalence was reported for analysis conducted during 2014-2015. Results: Among 2,351 male and female shipboard personnel, 39%-54% screened positive for hazardous, 27% for binge, and 15% for dependent alcohol use. Seven percent reported involuntary drug consumption history. A larger proportion of those aged 17-20 years screened positive for dependent alcohol use compared with the overall study population prevalence. Conclusions: A large proportion of shipboard personnel screened positive for hazardous and dependent alcohol use (18% among those aged <21 years) at deployment onset. These data can inform interventions targeting shipboard personnel engaging in hazardous use before progression to dependent use and enable early identification and care for dependent users. Future studies should include more comprehensive assessment of factors associated with involuntary drug consumption. (C) 2016 American Journal of Preventive Medicine. Published by Elsevier Inc. C1 [Harbertson, Judith; Michael, Nelson L.; Scott, Paul T.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Harbertson, Judith] Adv Mil Med Inc, Henry M Jackson Fdn, Bethesda, MD USA. [Harbertson, Judith; Hale, Braden R.] Naval Hlth Res Ctr, Dept Def HIV, AIDS Prevent Program, 140 Sylvester Rd, San Diego, CA 92106 USA. [Hale, Braden R.] Univ Calif San Diego, Dept Infect Dis, La Jolla, CA 92093 USA. [Watkins, Eren Y.] Army Publ Hlth Ctr Provis, Behav & Social Hlth Outcomes Program, Aberdeen Proving Ground, MD USA. RP Harbertson, J (reprint author), Naval Hlth Res Ctr, Dept Def HIV, AIDS Prevent Program, 140 Sylvester Rd, San Diego, CA 92106 USA. EM judith.harbertson.ctr@mail.mil FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense [60546] FX The authors would like to thank Jerrica Nichols for conducting alcohol use analyses among U.S. Army service members and assistance with the interpretation. This work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense, under Work Unit No. 60546. The views expressed herein are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, or the U.S. Government. Approved for public release; distribution is unlimited. U.S. Government Work (17 USC 105). Not copyrighted in the U.S. This research was conducted in compliance with all applicable federal regulations governing the protection of human subjects in research (Protocol NHRC.2010.0033). NR 38 TC 0 Z9 0 U1 2 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 EI 1873-2607 J9 AM J PREV MED JI Am. J. Prev. Med. PD AUG PY 2016 VL 51 IS 2 BP 185 EP 194 DI 10.1016/j.amepre.2016.02.029 PG 10 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA DS0AB UT WOS:000380256400008 PM 27067304 ER PT J AU Fitzgerald, GK Fritz, JM Childs, JD Brennan, GP Talisa, V Gil, AB Neilson, BD Abbott, JH AF Fitzgerald, G. K. Fritz, J. M. Childs, J. D. Brennan, G. P. Talisa, V. Gil, A. B. Neilson, B. D. Abbott, J. H. TI Exercise, manual therapy, and use of booster sessions in physical therapy for knee osteoarthritis: a multi-center, factorial randomized clinical trial SO OSTEOARTHRITIS AND CARTILAGE LA English DT Article DE Physical therapy; Knee; Osteoarthritis; Manual therapy; Exercise; Booster sessions ID HOME EXERCISE; HIP; PHYSIOTHERAPY; RECOMMENDATIONS; MANAGEMENT; CRITERIA; OUTCOMES; PEOPLE AB Objective: (1) Do treatment effects differ between participants receiving manual therapy (MT) with exercise compared to subjects who don't, (2) are treatment effects sustained better when participants receive booster sessions compared to those who don't over a one year period in subjects with knee osteoarthritis (KOA)? Design: Multi-center, 2 x 2 factorial randomized clinical trial. 300 participants with knee OA were randomized to four groups: exercise-no boosters (Ex), exercise-with boosters (Ex+B), manual therapy+exercise-no boosters (MT+Ex), manual therapy+exercise-with boosters (MT+Ex+B). The primary outcome was the Western Ontario and McMaster osteoarthritis index (WOMAC) at 1 year. Secondary outcomes included knee pain, physical performance tests, and proportions of participants meeting treatment responder criteria. Results: There were no differences between groups on the WOMAC at 1 year or on any performance-based measures. Secondary analyses indicated a) better scores on the WOMAC and greater odds of being a treatment responder at 9 weeks for participants receiving MT, b) greater odds of being a treatment responder at 1 year for participants receiving boosters. Exploratory interaction analysis suggested knee pain decreases for participants receiving boosters and increases for participants not receiving boosters from 9 weeks to 1 year. Conclusions: MT or use of boosters with exercise did not result in additive improvement in the primary outcome at 1 year. Secondary outcomes suggest MT may have some short term benefit, and booster sessions may improve responder status and knee pain at 1 year. However, the role of booster sessions remains unclear in sustaining treatment effects and warrants further study. (C) 2016 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved. C1 [Fitzgerald, G. K.; Gil, A. B.] Univ Pittsburgh, Sch Hlth & Rehabil Sci, Dept Phys Therapy, Pittsburgh, PA USA. [Fritz, J. M.] Univ Utah, Coll Hlth, Dept Phys Therapy, Associate Dean Res, Salt Lake City, UT USA. [Childs, J. D.] US Army, Baylor Univ, San Antonio, TX USA. [Brennan, G. P.] Rehabil Serv, Intermt Healthcare, Salt Lake City, UT USA. [Talisa, V.] Univ Pittsburgh, Grad Sch Publ Hlth, Res Ctr, Hlth Care Data Ctr,Dept Biostat, Pittsburgh, PA USA. [Neilson, B. D.] Henry M Jackson Fdn Adv Mil Med, Schertz, TX USA. [Abbott, J. H.] Univ Otago, Ctr Musculoskeletal Outcomes Res, Dunedin Sch Med, Dept Surg Sci, Dunedin, New Zealand. RP Fitzgerald, GK (reprint author), Univ Pittsburgh, Dept Phys Therapy, Bridgeside Point 1,100 Technol Dr,Suite 210, Pittsburgh, PA 15219 USA. EM kfitzger@pitt.edu OI Abbott, J. Haxby/0000-0001-6468-7284 FU Agency for Healthcare Research and Quality (AHRQ) [R01HS019624-01] FX This study was funded by a grant from the Agency for Healthcare Research and Quality (AHRQ), grant# R01HS019624-01. The study sponsors did not play a role in the study design, collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication. NR 24 TC 0 Z9 0 U1 19 U2 24 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1063-4584 EI 1522-9653 J9 OSTEOARTHR CARTILAGE JI Osteoarthritis Cartilage PD AUG PY 2016 VL 24 IS 8 BP 1340 EP 1349 DI 10.1016/j.joca.2016.03.001 PG 10 WC Orthopedics; Rheumatology SC Orthopedics; Rheumatology GA DR9VV UT WOS:000380245100004 PM 26973326 ER PT J AU Howard, JT Sparks, PJ AF Howard, Jeffrey T. Sparks, P. Johnelle TI The Effects of Allostatic Load on Racial/Ethnic Mortality Differences in the United States SO POPULATION RESEARCH AND POLICY REVIEW LA English DT Article DE Allostatic load; Mortality disadvantage; Health disparities ID CUMULATIVE BIOLOGICAL RISK; ALL-CAUSE MORTALITY; RACIAL RESIDENTIAL SEGREGATION; U.S. ADULT MORTALITY; SOCIOECONOMIC-STATUS; US ADULTS; HISPANIC PARADOX; EDUCATIONAL-DIFFERENCES; SOCIAL CONDITIONS; HEALTH-INSURANCE AB This study expands on previous findings of racial/ethnic and allostatic load (AL) associations with mortality by addressing whether differential AL levels by race/ethnicity may explain all-cause mortality differences. This study used data from the third National Health and Nutrition Survey public-use file, gathered between 1988 and 1994, with up to 18 years of mortality follow-up (n = 11,733). AL scores were calculated using a 10-biomarker algorithm based on clinically determined thresholds. Results of discrete-time hazard models suggest that AL is associated with increased mortality risks, independent of other factors, including race/ethnicity and SES. The results also suggest that the AL-mortality association is stronger for non-Hispanic blacks than for non-Hispanic whites, and that at low levels of AL observed mortality differences between non-Hispanic blacks and non-Hispanic whites are non-significant. These findings suggest that mortality differences between non-Hispanic blacks and non-Hispanic whites may be the result of how early life exposure causes premature aging and increased mortality risks. More attention to resource allocation and local environments is needed to understand why non-Hispanic blacks experience premature aging that leads to differential mortality risks compared to non-Hispanic whites. C1 [Howard, Jeffrey T.] US Army Inst Surg Res, Dept Epidemiol & Biostat, Ft Sam Houston, TX USA. [Sparks, P. Johnelle] Univ Texas San Antonio, Dept Demog, San Antonio, TX USA. RP Howard, JT (reprint author), US Army Inst Surg Res, Dept Epidemiol & Biostat, Ft Sam Houston, TX USA. EM jeffhoward01@gmail.com FU University of Texas Board of Regents Jess Hay Chancellor's Fellowship; Postdoctoral Fellowship - Oak Ridge Institute of Science and Education FX This study was partially funded by the University of Texas Board of Regents Jess Hay Chancellor's Fellowship and by a Postdoctoral Fellowship granted by the Oak Ridge Institute of Science and Education. NR 126 TC 0 Z9 0 U1 14 U2 18 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0167-5923 EI 1573-7829 J9 POPUL RES POLICY REV JI Popul. Res. Policy Rev. PD AUG PY 2016 VL 35 IS 4 BP 421 EP 443 DI 10.1007/s11113-016-9382-4 PG 23 WC Demography SC Demography GA DR8FM UT WOS:000380133800001 ER PT J AU Yu, KM Sarney, WL Novikov, SV Segercrantz, N Ting, M Shaw, M Svensson, SP Martin, RW Walukiewicz, W Foxon, CT AF Yu, K. M. Sarney, W. L. Novikov, S. V. Segercrantz, N. Ting, M. Shaw, M. Svensson, S. P. Martin, R. W. Walukiewicz, W. Foxon, C. T. TI Highly mismatched GaN1-xSbx alloys: synthesis, structure and electronic properties SO SEMICONDUCTOR SCIENCE AND TECHNOLOGY LA English DT Review DE highly mismatched alloys; nitride; band anticrossing; electronic band structure; photoelectrochemical water splitting ID MOLECULAR-BEAM EPITAXY; LOW-TEMPERATURE GROWTH; VAPOR-PHASE EPITAXY; BAND-GAP ENERGY; COMPOSITION DEPENDENCE; OPTICAL-PROPERTIES; GALLIUM-NITRIDE; LASER-DIODES; SOLAR-CELLS; THIN-FILMS AB Highly mismatched alloys (HMAs) is a class of semiconductor alloys whose constituents are distinctly different in terms of size, ionicity and/or electronegativity. Electronic properties of the alloys deviate significantly from an interpolation scheme based on small deviations from the virtual crystal approximation. Most of the HMAs were only studied in a dilute composition limit. Recent advances in understanding of the semiconductor synthesis processes allowed growth of thin films of HMAs under non-equilibrium conditions. Thus reducing the growth temperature allowed synthesis of group III-N-V HMAs over almost the entire composition range. This paper focuses on the GaNxSb1-x HMA which has been suggested as a potential material for solar water dissociation devices. Here we review our recent work on the synthesis, structural and optical characterization of GaN1-xSbx HMA. Theoretical modeling studies on its electronic structure based on the band anticrossing (BAC) model are also reviewed. In particular we discuss the effects of growth temperature, Ga flux and Sb flux on the incorporation of Sb, film microstructure and optical properties of the alloys. Results obtained from two separate MBE growths are directly compared. Our work demonstrates that a large range of direct bandgap energies from 3.4 eV to below 1.0 eV can be achieved for this alloy grown at low temperature. We show that the electronic band structure of GaN1-xSbx HMA over the entire composition range is well described by a modified BAC model which includes the dependence of the host matrix band edges as well as the BAC model coupling parameters on composition. We emphasize that the modified BAC model of the electronic band structure developed for the full composition of GaN(x)Sb(1-)x is general and is applicable to any HMA. C1 [Yu, K. M.] City Univ Hong Kong, Dept Phys & Mat Sci, Kowloon, Hong Kong, Peoples R China. [Yu, K. M.; Segercrantz, N.; Ting, M.; Walukiewicz, W.] Lawrence Berkeley Natl Lab, Div Mat Sci, 1 Cyclotron Rd, Berkeley, CA 94720 USA. [Sarney, W. L.; Svensson, S. P.] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Novikov, S. V.; Foxon, C. T.] Univ Nottingham, Sch Phys & Astron, Nottingham NG7 2RD, England. [Segercrantz, N.] Aalto Univ, Dept Appl Phys, FI-00076 Aalto, Finland. [Ting, M.] Univ Calif Berkeley, Dept Mech Engn, Berkeley, CA 94720 USA. [Shaw, M.; Martin, R. W.] Univ Strathclyde, SUPA, Dept Phys, Glasgow G4 0NG, Lanark, Scotland. RP Yu, KM (reprint author), City Univ Hong Kong, Dept Phys & Mat Sci, Kowloon, Hong Kong, Peoples R China.; Yu, KM (reprint author), Lawrence Berkeley Natl Lab, Div Mat Sci, 1 Cyclotron Rd, Berkeley, CA 94720 USA. EM kinmanyu@cityu.edu.hk OI Yu, Kin Man/0000-0003-1350-9642 FU EPSRC [EP/I004203/1]; US Army [W911NF-12-2-0003]; US Department of Energy, Office of Science, Basic Energy Sciences, Materials Sciences and Engineering Division [DE-AC02-05CH11231]; General Research Fund of the Research Grants Council of Hong Kong SAR, China [CityU 11303715] FX The MBE growth at the University of Nottingham was undertaken with support from the EPSRC (EP/I004203/1) and by the US Army under cooperative agreement No. W911NF-12-2-0003. RBS and optical measurements and theoretical modeling were performed in the EMAT program at LBNL and were supported by the US Department of Energy, Office of Science, Basic Energy Sciences, Materials Sciences and Engineering Division under Contract No. DE-AC02-05CH11231. KMY acknowledges the support of the General Research Fund of the Research Grants Council of Hong Kong SAR, China, under project number CityU 11303715. The characterization work at Strathclyde University was funded by EPSRC grant number EP/I004203/1. There are no EPSRC-related datasets associated with this publication. NR 107 TC 0 Z9 0 U1 17 U2 28 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0268-1242 EI 1361-6641 J9 SEMICOND SCI TECH JI Semicond. Sci. Technol. PD AUG PY 2016 VL 31 IS 8 AR 083001 DI 10.1088/0268-1242/31/8/083001 PG 22 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Condensed Matter SC Engineering; Materials Science; Physics GA DR9NK UT WOS:000380223200002 ER PT J AU Todd, CS Mansoor, GF Buhler, C Rahimi, H Zekria, R Fernandez, S Mikhail, AFW Scott, PT Yingst, SL AF Todd, Catherine S. Mansoor, Ghulam Farooq Buhler, Cyril Rahimi, Habiburrahman Zekria, Rohullah Fernandez, Stefan Mikhail, Amy F. W. Scott, Paul T. Yingst, Samuel L. TI Prevalence of Zoonotic and Vector-Borne Infections Among Afghan National Army Recruits in Afghanistan SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Afghanistan; Brucellosis; Crimean-Congo hemorrhagic fever; Malaria; Vector-borne infections ID CONGO HEMORRHAGIC-FEVER; MALARIA; BRUCELLOSIS; FORCES AB Objective: To measure prevalence of prior/current Plasmodium vivax and Plasmodium falciparum (PV and PF), Brucella spp. (BR), dengue virus (DENV), Leishmania donovani (visceral leishmaniasis; VL), and Crimean-Congo hemorrhagic fever (CCHF) virus exposure among Afghan National Army (ANA) recruits. Methods: Randomly chosen, nationally representative serum samples from consenting men aged 18-40 years and who were screened between February 2010 and January 2011 were tested, with similar to 25 samples/province. Samples were screened for PV and PF antigens and VL antibody with rapid diagnostic tests. Reactive malaria screening results were confirmed with polymerase chain reaction assay. Enzyme-linked immunosorbent assays were used to screen for CCHF and DENV antibodies; reactive DENV samples were confirmed with the plaque-reduction neutralization test. BR screening and confirmatory testing was performed with slide and tube agglutination, respectively. Correlates of BR titres >1:80 were analyzed using logistic regression. Results: Of 809 participants contributing specimens, 62% had previously lived outside Afghanistan, predominantly in Pakistan and Iran. CCHF (4.1%, n = 33), DENV (2.1%, n = 17), and VL (1.0%, n = 8) antibody prevalence was low. For PV and PF, only 7 out of 56 reactive samples had detectable nucleic acid. For BR, 8.0% (n = 65) of samples had screening titers >1:40, of which 83.1% had confirmatory titers >1:80. Participants from Kabul and surrounding provinces had lower odds (OR = 0.19, 95% CI: 0.04-1.00) of BR antibody compared with other regions. Conclusions: BR exposure was relatively common with a nearly national distribution, whereas geographic distribution for other pathogens aligned roughly with the expected vector distribution. Public health protection measures should include vector control, food safety, and enhanced diagnostics for acute febrile illness. C1 [Todd, Catherine S.] FHI 360, Asia Pacific Reg Off, Bangkok, Thailand. [Todd, Catherine S.] FHI 360, Div Clin Sci, Bangkok, Thailand. [Mansoor, Ghulam Farooq; Rahimi, Habiburrahman; Zekria, Rohullah; Mikhail, Amy F. W.] Hlth Protect & Res Org, Kabul, Afghanistan. [Buhler, Cyril] ORDiagnostics SA, Paris, France. [Fernandez, Stefan] US Army Med Component, Armed Forces Res Inst Med Sci, Dept Virol, Bangkok, Thailand. [Scott, Paul T.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Yingst, Samuel L.] US Army Med Component, Armed Forces Res Inst Med Sci, Dept Epidemiol & Dis Surveillance, Bangkok, Thailand. [Yingst, Samuel L.] Purdue Univ, Coll Vet Med, 625 Harrison St, W Lafayette, IN 47907 USA. RP Yingst, SL (reprint author), Purdue Univ, Coll Vet Med, 625 Harrison St, W Lafayette, IN 47907 USA. EM yingst@purdue.edu FU Global Emerging Infections Surveillance (GEIS) division of the U.S. Armed Forces Health Surveillance Center FX This study was funded by the Global Emerging Infections Surveillance (GEIS) division of the U.S. Armed Forces Health Surveillance Center. The opinions or assertions contained here are the private views of the authors, and they are not to be construed as official, or as reflecting the true views of the United States Department of the Army or the Department of Defense. NR 22 TC 0 Z9 0 U1 3 U2 3 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 EI 1557-7759 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD AUG PY 2016 VL 16 IS 8 BP 501 EP 506 DI 10.1089/vbz.2015.1921 PG 6 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA DR7VR UT WOS:000380108300002 PM 27304051 ER PT J AU Bhowmik, T Niu, N Wang, WT Cheng, JRC Li, L Cao, XF AF Bhowmik, Tanmay Niu, Nan Wang, Wentao Cheng, Jing-Ru C. Li, Ling Cao, Xiongfei TI Optimal Group Size for Software Change Tasks: A Social Information Foraging Perspective SO IEEE TRANSACTIONS ON CYBERNETICS LA English DT Article DE Cybernetic application; group size; productivity; social information foraging theory; task assignment ID NETWORKED MULTIAGENT SYSTEMS; CONFIGURATION MANAGEMENT; TEAM SIZE; COLLABORATION; PRODUCTIVITY; DEVELOPERS; SIMULATION; PROJECT; MODEL AB Group size is a key factor in collaborative software development and many other cybernetic applications where task assignments are important. While methods exist to estimate its value for proprietary projects, little is known about how group size affects distributed and decentralized cybernetic applications and in particular open source software (OSS) development. This paper presents a novel approach in which we frame developers' collective resolution of OSS change tasks as a social information foraging problem. This new perspective enables us to predict the optimal group size and quantify group size's effect on individual performance. We test the theory with data mined from two projects: 1) Firefox and 2) Mylyn. This paper not only uncovers the mismatch of optimal and actual group sizes, but also reveals the association of optimality with improved productivity. In addition, the social-level productivity gain is observed as project evolves. We show this paper's impact by extending the frontiers of knowledge in two areas: 1) social coding and 2) recommendation systems. C1 [Bhowmik, Tanmay] Mississippi State Univ, Dept Comp Sci & Engn, Mississippi State, MS 39759 USA. [Niu, Nan; Wang, Wentao] Univ Cincinnati, Dept Elect Engn & Comp Syst, Cincinnati, OH 45221 USA. [Cheng, Jing-Ru C.] US Army, Engn Res & Dev Ctr, Informat Technol Lab, Vicksburg, MS 39180 USA. [Li, Ling] Old Dominion Univ, Dept Informat Technol & Decis Sci, Norfolk, VA 23529 USA. [Cao, Xiongfei] Univ Sci & Technol China, Sch Management, Hefei 230026, Peoples R China. RP Cao, XF (reprint author), Univ Sci & Technol China, Sch Management, Hefei 230026, Peoples R China. EM caoxf312@126.com OI Niu, Nan/0000-0001-5566-2368 FU U.S. National Science Foundation [CCF-1350487] FX This work was supported by the U.S. National Science Foundation under Grant CCF-1350487. This paper was recommended by Associate Editor L. D. Xu. NR 77 TC 1 Z9 1 U1 1 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 2168-2267 EI 2168-2275 J9 IEEE T CYBERNETICS JI IEEE T. Cybern. PD AUG PY 2016 VL 46 IS 8 BP 1784 EP 1795 DI 10.1109/TCYB.2015.2420316 PG 12 WC Computer Science, Artificial Intelligence; Computer Science, Cybernetics SC Computer Science GA DR6AW UT WOS:000379984500007 PM 25910274 ER PT J AU Shukla, MK AF Shukla, Manoj K. TI Computational prediction of electronic excited-state structures and properties of 2,4-dinitroanisole (DNAN) SO STRUCTURAL CHEMISTRY LA English DT Article DE DNAN; TD-DFT; Electronic singlet excitation; CPCM model; Excited-state geometry ID INSENSITIVE MUNITIONS COMPOUND; NITROBENZENE; RELAXATION; MOLECULES AB This manuscript reports results of density functional theory (DFT) investigation on ground-state and electronic excited-state structures of 2,4-dinitroanisole (DNAN) in the bulk water solution. The cam-B3LYP functional along with 6-311G(d,p) basis set was used, and time-dependent DFT (TD-DFT) method was used for excited-state calculations. The effect of bulk water was modeled using the CPCM approach. Nature of potential energy surfaces (PESs) was ascertained through the harmonic vibrational frequency analysis; all optimized geometries were found to be minima at the respective PESs. It was predicted that singlet excited-state geometries are significantly changed compared to the ground state. Further, it was also revealed that irrespective of nature of the electronic singlet excited states, the length of C7O1 bond is increased compared to the ground state. Further, electronic structures and properties consequent to electronic excitations are also discussed. C1 [Shukla, Manoj K.] US Army, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Shukla, MK (reprint author), US Army, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM Manoj.K.Shukla@usace.army.mil NR 13 TC 0 Z9 0 U1 3 U2 5 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1040-0400 EI 1572-9001 J9 STRUCT CHEM JI Struct. Chem. PD AUG PY 2016 VL 27 IS 4 BP 1143 EP 1148 DI 10.1007/s11224-015-0736-z PG 6 WC Chemistry, Multidisciplinary; Chemistry, Physical; Crystallography SC Chemistry; Crystallography GA DR6AI UT WOS:000379983100011 ER PT J AU D'Angelo, PA Bromberg, L Hatton, TA Wilusz, E AF D'Angelo, Paola A. Bromberg, Lev Hatton, T. Alan Wilusz, Eugene TI Sensing and inactivation of Bacillus anthracis Sterne by polymer-bromine complexes SO APPLIED MICROBIOLOGY AND BIOTECHNOLOGY LA English DT Article DE Spores; Anthrax decontamination; DPA release from inactivated anthrax; Brominated polymer decontaminants; Sensing anthrax by DPA release ID SPORE GERMINATION; SUBTILIS; COAT; SURFACES; CHLORINE; BACTERIA; AGENTS; HYDROTRIBROMIDE; ARCHITECTURE; ENDOSPORES AB We report on the performance of brominated poly(N-vinylpyrrolidone) (PVP-Br), brominated poly(ethylene glycol) (PEG-Br), and brominated poly(allylamine-co-4-aminopyridine) (PAAm-APy-Br) for their ability to decontaminate Bacillus anthracis Sterne spores in solution while also allowing for the sensing of the spores. The polymers were brominated by bromine using carbon tetrachloride or potassium tribromide as solvents, with bromine loadings ranging from 1.6 to 4.2 mEq/g of polymer. B. anthracis Sterne spores were exposed to increasing concentrations of brominated polymers for 5 min, while the kinetics of the sporicidal activity was assessed. All brominated polymers demonstrated spore log-kills of 8 within 5 min of exposure at 12 mg/mL aqueous polymer concentration. Sensing of spores was accomplished by measuring the release of dipicolinic acid (DPA) from the spore using time-resolved fluorescence. Parent, non-brominated polymers did not cause any release of DPA and the spores remained viable. In contrast, spores exposed to the brominated polymers were inactivated and the release of DPA was observed within minutes of exposure. Also, this release of DPA continued for a long time after spore inactivation as in a controlled release process. The DPA release was more pronounced for spores exposed to brominated PVP and brominated PEG-8000 compared to brominated PAAm-APy and brominated PEG-400. Using time-resolved fluorescence, we detected as low as 2500 B. anthracis spores, with PEG-8000 being more sensitive to low spore numbers. Our results suggest that the brominated polymers may be used effectively as decontamination agents against bacterial spores while also providing the sensing capability. C1 [D'Angelo, Paola A.; Wilusz, Eugene] US Army, Natick Soldier Res Dev & Engn Ctr, Warfighter Directorate, 15 Gen Greene Ave, Natick, MA 01760 USA. [Bromberg, Lev; Hatton, T. Alan] MIT, Dept Chem Engn, Cambridge, MA 02139 USA. RP D'Angelo, PA (reprint author), US Army, Natick Soldier Res Dev & Engn Ctr, Warfighter Directorate, 15 Gen Greene Ave, Natick, MA 01760 USA. EM paola.a.dangelo.civ@mail.mil FU Defense Threat Reduction Agency (DTRA) FX This work was financially supported by the Defense Threat Reduction Agency (DTRA). NR 43 TC 0 Z9 0 U1 7 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0175-7598 EI 1432-0614 J9 APPL MICROBIOL BIOT JI Appl. Microbiol. Biotechnol. PD AUG PY 2016 VL 100 IS 15 BP 6847 EP 6857 DI 10.1007/s00253-016-7507-7 PG 11 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA DQ6LU UT WOS:000379317300028 PM 27087522 ER PT J AU Druwe, IL Burgoon, L AF Druwe, Ingrid L. Burgoon, Lyle TI Revisiting Cohen et al. 2015, Cohen et al. 2014 and Waalkes et al. 2014: a bayesian re-analysis of tumor incidences SO ARCHIVES OF TOXICOLOGY LA English DT Letter ID EXPOSURE; MICE C1 [Druwe, Ingrid L.] US EPA, Oak Ridge Inst Sci & Educ, Natl Ctr Environm Assessment, Vicksburg, MS USA. [Burgoon, Lyle] US Army, Engineer Res & Dev Ctr, Environm Lab, Res Triangle Pk, NC 27709 USA. RP Burgoon, L (reprint author), US Army, Engineer Res & Dev Ctr, Environm Lab, Res Triangle Pk, NC 27709 USA. EM lyle.d.burgoon@usace.army.mil OI Burgoon, Lyle/0000-0003-4977-5352 NR 3 TC 3 Z9 3 U1 0 U2 1 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0340-5761 EI 1432-0738 J9 ARCH TOXICOL JI Arch. Toxicol. PD AUG PY 2016 VL 90 IS 8 BP 2047 EP 2048 DI 10.1007/s00204-016-1749-0 PG 2 WC Toxicology SC Toxicology GA DQ5OK UT WOS:000379254500021 PM 27325233 ER PT J AU Kim, H Shen, ZH Kim, I Kim, K Stumpf, A Yu, J AF Kim, Hyunjoo Shen, Zhenhua Kim, Inhan Kim, Karam Stumpf, Annette Yu, Jungho TI BIM IFC information mapping to building energy analysis (BEA) model with manually extended material information SO AUTOMATION IN CONSTRUCTION LA English DT Article DE IFC; Building Information Modeling (BIM); Energy modeling; Energy simulation Design improvement ID SIMULATION; SCHEDULES; SYSTEM AB To reduce fossil fuel based energy consumption in buildings, different methods have been proposed. Interestingly, one of the most significant factors in building energy consumption has been reported in the area of improving building designs. However, building energy analysis (BEA) is typically conducted late in design, by energy analyst specialists. The ability to try out new ideas early in the design process in order to choose the best alternative is not ordinarily taken advantage of, due to the difficulty and expense of modeling the building and energy systems. Building information modeling (BIM) provides the user with an opportunity to explore different energy saving alternatives in the design process while avoiding the time-consuming process of re-entering all the building geometry, enclosure, and HVAC information necessary for a complete energy analysis. While significant time savings are being made by not having to create the building geometry within the simulation interface in BIM energy modeling simulation, there is a good possibility of missing, misplaced, or deformed building elements during a BIM data exchange process. This research focuses on one of the major limitations - inaccuracies through simplifications in construction/material data - and aims to improve the accuracy of energy modeling process by developing an object based approach in materials in which the energy modeler may change and expand various properties in building materials. In testing the performance of the proposed approach, the results from the proposed energy modeling process in the case study are compared to those of existing energy modeling software which showed significant gains in accuracy. (C) 2016 Elsevier B.V. All rights reserved. C1 [Kim, Hyunjoo] Univ Seoul, Dept Global Construct Management, Seoul, South Korea. [Shen, Zhenhua] Univ N Carolina, Dept Engn Technol & Construct Management, Charlotte, NC USA. [Kim, Inhan] Kyung Hee Univ, Coll Engn, Dept Architecture, 1732 Deogyeong Daero, Yongin 446701, Gyeonggi Do, South Korea. [Kim, Karam; Yu, Jungho] Kwangwoon Univ, Dept Architectural Engn, 447-1 Wolgye Dong, Seoul 139070, South Korea. [Stumpf, Annette] US Army Engineer Res & Dev Ctr, Construct Engn Res Lab, 2902 Newmark Dr, Champaign, IL 61824 USA. RP Yu, J (reprint author), Kwangwoon Univ, Dept Architectural Engn, 447-1 Wolgye Dong, Seoul 139070, South Korea. EM hkim01@uos.ac.kr; zshen1@uncc.edu; ihkim@khu.ac.kr; karamiz@kw.ac.kr; Annette.L.Stumpf@usace.army.mil; myazure@kw.ac.kr FU Architecture & Urban Development Research Program - Ministry of Land, Infrastructure and Transport of the Korean government [15-AUDP-0067817-03]; Kwangwoon University FX This research was supported by a grant (15-AUDP-0067817-03) from the Architecture & Urban Development Research Program funded by the Ministry of Land, Infrastructure and Transport of the Korean government.; The present research has been conducted by the Research Grant of Kwangwoon University in 2015. NR 32 TC 1 Z9 1 U1 29 U2 44 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0926-5805 EI 1872-7891 J9 AUTOMAT CONSTR JI Autom. Constr. PD AUG PY 2016 VL 68 BP 183 EP 193 DI 10.1016/j.autcon.2016.04.002 PG 11 WC Construction & Building Technology; Engineering, Civil SC Construction & Building Technology; Engineering GA DQ7FA UT WOS:000379371100016 ER PT J AU Zhang, XH Palazzolo, A Tucker, R Kascak, A Kweon, CB AF Zhang, Xiaohua Palazzolo, Alan Tucker, Randall Kascak, Albert Kweon, Chol-Bum TI Flash vapor fuel injector development SO INTERNATIONAL JOURNAL OF ENGINE RESEARCH LA English DT Article DE Flash heating; direct fuel injection; JP-8; spark ignition engines; JP-8 coking; ignition delay AB Following the single-fuel initiative, the US Army is transitioning its power plants from running on various fuels to a single fuel-JP-8. Due to its low vapor pressure, JP-8 could not be used to cold start or run gasoline engines without extensive retrofit. The feasibility of running a low compression ratio, spark ignition engine with direct injection of heated JP-8 was investigated. A preliminary study found that a small piston-type spark ignition engine would not start or run on JP-8 unless JP-8 was heated to certain temperature. JP-8' s thermal decomposition, or coking, was found to be a serious issue that must be addressed if fuel heating method would be used. A flash heater concept was proposed to solve problems of JP-8' s low vapor pressure on running low compression ratio spark ignition engines, as well as JP-8' s coking issue at high temperature. A flash vapor fuel injector was designed and tested to be capable of heating up JP-8 from 26.7 degrees C to its vaporization temperature of > 154.4 degrees C under one-tenth of a second at the required flow rate. The longest duration heating test (> 1 million injections) did not show any coking sign with flash heating. Ignition test results show equivalent or superior ignition characteristics of pre-heated JP-8 (with heater temperature at 260.0 degrees C or above) provided by the developed flash vapor fuel injector, compared with non-heated aviation gasoline. C1 [Zhang, Xiaohua; Palazzolo, Alan] Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA. [Kascak, Albert] US Army Res Lab, Cleveland, OH USA. [Kweon, Chol-Bum] US Army Res Lab, Aberdeen Proving Ground, MD USA. RP Palazzolo, A (reprint author), Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA. EM a-palazzolo@tamu.edu FU FundRef Funding Sources US Army Research Laboratory [C1000570] FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The authors acknowledge FundRef Funding Sources US Army Research Laboratory for providing the funding for this project (Grant/Award Number: "contract C1000570"). NR 18 TC 0 Z9 0 U1 6 U2 6 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1468-0874 EI 2041-3149 J9 INT J ENGINE RES JI Int. J. Engine Res. PD AUG PY 2016 VL 17 IS 6 BP 646 EP 665 DI 10.1177/1468087415597811 PG 20 WC Thermodynamics; Engineering, Mechanical; Transportation Science & Technology SC Thermodynamics; Engineering; Transportation GA DR1DQ UT WOS:000379646600004 ER PT J AU Abu Nahid, M Benso, LM Shin, JD Mehmet, H Hicks, A Ramadas, RA AF Abu Nahid, M. Benso, Lia M. Shin, John D. Mehmet, Huseyin Hicks, Alexandra Ramadas, Ravisankar A. TI TLR4, TLR7/8 agonist-induced miR-146a promotes macrophage tolerance to MyD88-dependent TLR agonists SO JOURNAL OF LEUKOCYTE BIOLOGY LA English DT Article DE microRNA; tolerance ID TOLL-LIKE RECEPTORS; KAPPA-B ACTIVATION; CROSS-TOLERANCE; ENDOTOXIN TOLERANCE; IMMUNE-RESPONSES; LIPOTEICHOIC ACID; GENE-EXPRESSION; INNATE IMMUNITY; CELL-DEATH; CPG-DNA AB TLRs facilitate the recognition of pathogens by immune cells and the initiation of the immune response, leading to the production of proinflammatory cytokines and chemokines. Production of proinflammatory mediators by innate immune cells, such as macrophages, is tightly regulated to facilitate pathogen clearance while limiting an adverse impact on host tissue. Exposure of innate immune cells to TLR ligands induces a state of temporary refractoriness to a subsequent exposure of a TLR ligand, a phenomenon referred to as "tolerance." This study sought to evaluate the mechanistic regulation of TLR4 and TLR7/8 ligand-induced tolerance to other TLRs by microRNA-146a. With the use of THP-1 macrophages, as well as human classic and alternative macrophages, we demonstrate that priming with a TLR4 agonist (LPS) or a TLR7/8 agonist (R848) induces homologous and heterologous tolerance to various TLR ligands in macrophages, leading to the impaired production of cytokines and chemokines. We also demonstrate that overexpression of microRNA-146a is sufficient to mimic LPS or R848-induced hyporesponsiveness. Conversely, inhibition of microRNA-146a activity leads to LPS-or R848-induced TLR hyper-responsiveness in TLR signaling tolerance. Furthermore, we demonstrate that microRNA-146a dampens cytokine production following a primary stimulus with MyD88-dependent but not MyD88-independent TLR pathways. Collectively, these data provide comprehensive evidence of the central role of microRNA-146a in TLR signaling tolerance to plasma membrane, as well as endosomal TLR ligands in human macrophages. C1 [Abu Nahid, M.; Benso, Lia M.; Shin, John D.; Mehmet, Huseyin; Hicks, Alexandra; Ramadas, Ravisankar A.] Merck Res Labs, Immunol Oncol & Immunomodulatory Receptors Discov, Boston, MA USA. [Abu Nahid, M.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Shin, John D.] Biogen, Cambridge, MA USA. [Mehmet, Huseyin] Proteostasis Therapeut, Cambridge, MA USA. [Hicks, Alexandra] Onkaido, Cambridge, MA USA. RP Ramadas, RA (reprint author), Merck Res Labs, Immunol Oncol & IMR Discovery Res, 33 Ave Louis Pasteur, Boston, MA 02115 USA. EM ravisankar.ramadas@merck.com FU Merck Co. FX This research was fully supported by Merck & Co. The authors thank Philip Garrett-Engele for his technical expertise and assistance. NR 50 TC 0 Z9 0 U1 3 U2 9 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0741-5400 EI 1938-3673 J9 J LEUKOCYTE BIOL JI J. Leukoc. Biol. PD AUG PY 2016 VL 100 IS 2 BP 339 EP 349 DI 10.1189/jlb.2A0515-197R PG 11 WC Cell Biology; Hematology; Immunology SC Cell Biology; Hematology; Immunology GA DR2MM UT WOS:000379738600009 ER PT J AU Hackett, M Proctor, M AF Hackett, Matthew Proctor, Michael TI Three-Dimensional Display Technologies for Anatomical Education: A Literature Review SO JOURNAL OF SCIENCE EDUCATION AND TECHNOLOGY LA English DT Review DE Anatomy; Education; Three-dimensional; Visualization; Display ID CHINESE VISIBLE HUMAN; QUICKTIME VIRTUAL-REALITY; SURGICAL LIVER ANATOMY; COMPUTER-MODELS; TRADITIONAL METHODS; FUTURE-DIRECTIONS; USER ACCEPTANCE; GROSS-ANATOMY; IMPROVE; VISUALIZATION AB Anatomy is a foundational component of biological sciences and medical education and is important for a variety of clinical tasks. To augment current curriculum and improve students' spatial knowledge of anatomy, many educators, anatomists, and researchers use three-dimensional (3D) visualization technologies. This article reviews 3D display technologies and their associated assessments for anatomical education. In the first segment, the review covers the general function of displays employing 3D techniques. The second segment of the review highlights the use and assessment of 3D technology in anatomical education, focusing on factors such as knowledge gains, student perceptions, and cognitive load. The review found 32 articles on the use of 3D displays in anatomical education and another 38 articles on the assessment of 3D displays. The review shows that the majority (74 %) of studies indicate that the use of 3D is beneficial for many tasks in anatomical education, and that student perceptions are positive toward the technology. C1 [Hackett, Matthew] Army Res Lab, 12423 Res Pkwy, Orlando, FL 32826 USA. [Hackett, Matthew; Proctor, Michael] Univ Cent Florida, Orlando, FL 32816 USA. RP Hackett, M (reprint author), Army Res Lab, 12423 Res Pkwy, Orlando, FL 32826 USA.; Hackett, M (reprint author), Univ Cent Florida, Orlando, FL 32816 USA. EM Matthew.G.Hackett.Civ@mail.mil; Michael.Proctor@ucf.edu NR 120 TC 0 Z9 0 U1 35 U2 49 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-0145 EI 1573-1839 J9 J SCI EDUC TECHNOL JI J. Sci. Educ. Technol. PD AUG PY 2016 VL 25 IS 4 BP 641 EP 654 DI 10.1007/s10956-016-9619-3 PG 14 WC Education & Educational Research; Education, Scientific Disciplines SC Education & Educational Research GA DR1XK UT WOS:000379698000010 ER PT J AU Li, ZY Ghosh, S Getinet, N O'Brien, DJ AF Li, Zhiye Ghosh, Somnath Getinet, Nebiyou O'Brien, Daniel J. TI Micromechanical modeling and characterization of damage evolution in glass fiber epoxy matrix composites SO MECHANICS OF MATERIALS LA English DT Article DE Glass fiber; Epoxy matrix; Non-local continuum damage mechanics; Strain-rate dependent; Cohesive zone models; RVE ID REPRESENTATIVE VOLUME ELEMENTS; INTERFACIAL NORMAL STRENGTH; STRAIN-RATE; GLASS/EPOXY COMPOSITES; REINFORCED COMPOSITES; DEFORMATION; MICROSTRUCTURES; HOMOGENIZATION; LOCALIZATION; BEHAVIOR AB This paper develops an experimentally calibrated and validated 3D finite element model for simulating strain-rate dependent deformation and damage behavior in representative volume elements of S-glass fiber reinforced epoxy-matrix composites. The fiber and matrix phases in the model are assumed to be elastic with their interfaces represented by potential-based and non-potential, rate-dependent cohesive zone models. Damage, leading to failure, in the fiber and matrix phases is modeled by a rate-dependent non-local scalar CDM model. The interface and damage models are calibrated using experimental results available in the literature, as well as from those conducted in this work. A limited number of tests are conducted with a cruciform specimen that is fabricated to characterize interfacial damage behavior. Validation studies are subsequently conducted by comparing results of FEM simulations with cruciform and from micro-droplet experiments. Sensitivity analyses are conducted to investigate the effect of mesh, material parameters and strain rate on the evolution of damage. Furthermore, their effect on partitions of the overall energy are also explored. Finally the paper examines the effect of microstructural morphology on the evolution of damage and its path. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Li, Zhiye] Johns Hopkins Univ, Dept Civil Engn, Baltimore, MD 21218 USA. [Ghosh, Somnath] Johns Hopkins Univ, Dept Civil Mech & Mat Sci & Engn, 3400 N Charles St, Baltimore, MD 21218 USA. [Getinet, Nebiyou; O'Brien, Daniel J.] US Army, Res Lab, Composite & Hybrid Mat Branch, Aberdeen, MD 21001 USA. RP Ghosh, S (reprint author), Johns Hopkins Univ, Dept Civil Mech & Mat Sci & Engn, 3400 N Charles St, Baltimore, MD 21218 USA. EM sghosh20@jhu.edu RI Ghosh, Somnath/A-2867-2012 FU Center for Materials in Extreme Dynamic Environments (CMEDE) of the Army Research Laboratory FX This work is sponsored by the Center for Materials in Extreme Dynamic Environments (CMEDE) of the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-12-2-0022. The sponsorship is gratefully acknowledged. Computational support of this work has been provided by the Homewood High Performance Compute Cluster (HHPC) at Johns Hopkins University. NR 55 TC 0 Z9 0 U1 16 U2 21 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-6636 EI 1872-7743 J9 MECH MATER JI Mech. Mater. PD AUG PY 2016 VL 99 BP 37 EP 52 DI 10.1016/j.mechmat.2016.05.006 PG 16 WC Materials Science, Multidisciplinary; Mechanics SC Materials Science; Mechanics GA DQ9YI UT WOS:000379564800005 ER PT J AU Margolis, LM Murphy, NE Martini, S Gundersen, Y Castellani, JW Karl, JP Carrigan, CT Teien, HK Madslien, EH Montain, SJ Pasiakos, SM AF Margolis, Lee M. Murphy, Nancy E. Martini, Svein Gundersen, Yngvar Castellani, John W. Karl, J. Philip Carrigan, Christopher T. Teien, Hilde-Kristin Madslien, Elisabeth-Henie Montain, Scott J. Pasiakos, Stefan M. TI Effects of Supplemental Energy on Protein Balance during 4-d Arctic Military Training SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE ENERGY EXPENDITURE; MACRONUTRIENTS; ENERGY BALANCE; MILITARY; WHOLE-BODY PROTEIN TURNOVER ID PREDICTING BODY DENSITY; DIETARY-PROTEIN; NITROGEN-BALANCE; GENERALIZED EQUATIONS; WEIGHT-LOSS; EXERCISE; MEN; TURNOVER; LEUCINE; EXPENDITURE AB Soldiers often experience negative energy balance during military operations that diminish whole-body protein retention, even when dietary protein is consumed within recommended levels (1.5-2.0 g.kg(-1).d(-1)). Purpose: The objective of this study is to determine whether providing supplemental nutrition spares whole-body protein by attenuating the level of negative energy balance induced by military training and to assess whether protein balance is differentially influenced by the macronutrient source. Methods: Soldiers participating in 4-d arctic military training (AMT) (51-km ski march) were randomized to receive three combat rations (CON) (n = 18), three combat rations plus four 250-kcal protein-based bars (PRO, 20 g protein) (n = 28), or three combat rations plus four 250-kcal carbohydrate-based bars daily (CHO, 48 g carbohydrate) (n = 27). Energy expenditure ((D2O)-O-18) and energy intake were measured daily. Nitrogen balance (NBAL) and protein turnover were determined at baseline (BL) and day 3 of AMT using 24-h urine and [N-15]-glycine. Results: Protein and carbohydrate intakes were highest (P < 0.05) for PRO (mean +/- SD, 2.0 +/- 0.3 g.kg(-1).d(-1)) and CHO (5.8 +/- 1.3 g.kg(-1).d(-1)), but only CHO increased (P < 0.05) energy intake above CON. Energy expenditure (6155 +/- 515 kcal.d(-1)), energy balance (-3313 +/- 776 kcal.d(-1)), net protein balance (NET) (-0.24 +/- 0.60 g.d(-1)), and NBAL (-68.5 +/- 94.6 mg.kg(-1).d(-1)) during AMT were similar between groups. In the combined cohort, energy intake was associated (P < 0.05) with NET (r = 0.56) and NBAL (r = 0.69), and soldiers with the highest energy intake (3723 +/- 359 kcal.d(-1), 2.11 +/- 0.45 g protein.kg(-1).d(-1), 6.654 +/- 1.16 g carbohydrate.kg(-1).d(-1)) achieved net protein balance and NBAL during AMT. Conclusion: These data reinforce the importance of consuming sufficient energy during periods of high energy expenditure to mitigate the consequences of negative energy balance and attenuate whole-body protein loss. C1 [Margolis, Lee M.; Murphy, Nancy E.; Karl, J. Philip; Carrigan, Christopher T.; Montain, Scott J.; Pasiakos, Stefan M.] US Army Res Inst Environm Med, Mil Nutr Div, 10 Gen Greene Ave,Bldg 42, Natick, MA 01760 USA. [Martini, Svein; Gundersen, Yngvar; Teien, Hilde-Kristin; Madslien, Elisabeth-Henie] Norwegian Def Res Estab, Kjeller, Norway. [Castellani, John W.] US Army Res Inst Environm Med, Thermal Mt & Med Div, Natick, MA USA. RP Pasiakos, SM (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, 10 Gen Greene Ave,Bldg 42, Natick, MA 01760 USA. EM stefan.m.pasiakos.civ@mail.mil RI Pasiakos, Stefan/E-6295-2014; OI Pasiakos, Stefan/0000-0002-5378-5820; , Lee/0000-0002-0652-1304 FU US Army Medical Research and Material Command; Norwegian Defense Research Establishment [W81XWH-12-0279] FX This work was supported by the US Army Medical Research and Material Command and the Norwegian Defense Research Establishment, under agreement no. W81XWH-12-0279. NR 41 TC 0 Z9 0 U1 2 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0195-9131 EI 1530-0315 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD AUG PY 2016 VL 48 IS 8 BP 1604 EP 1612 DI 10.1249/MSS.0000000000000944 PG 9 WC Sport Sciences SC Sport Sciences GA DR2TP UT WOS:000379757100021 PM 27054679 ER PT J AU Sobolev, K Lin, ZB Cao, YZ Sun, HF Flores-Vivian, I Rushing, T Cummins, T Weiss, WJ AF Sobolev, Konstantin Lin, Zhibin Cao, Yizheng Sun, Hongfang Flores-Vivian, Ismael Rushing, Todd Cummins, Toney Weiss, William Jason TI The influence of mechanical activation by vibro-milling on the early-age hydration and strength development of cement SO CEMENT & CONCRETE COMPOSITES LA English DT Article DE Mechanically activated cement; Vibro-mill; Calorimetry; Compressive strength; Degree of hydration ID IMPEDANCE SPECTROSCOPY; ECO-CEMENT; PASTE; ADMIXTURES; EVOLUTION; CONCRETE; SLAG AB This paper presents results from an experimental investigation that evaluated the mechanical activation of portland cement using vibro-milling. In this investigation, the duration of the vibro-milling was systematically varied and its influence was evaluated using mortar samples. In addition, the amount of activated cement used in the mortar samples was varied and evaluated. X-ray diffraction (XRD) and scanning electron microscopy (SEM) were used to evaluate differences in hydration products and the structure of activated cement and mortars. The activated cements were tested to determine the influence of activation on the rate of hydration and compressive strength development. The test results suggested that the use of mechanical activation can improve early-age structure formations and compressive strength. A 32% and 25% increase in 1-day strength were observed for the systems with Type I and Class H cements, respectively. This increase in 28-day strength was 16% and 58% for Type I and Class H cement, respectively. It was observed that longer milling times did not necessarily improve performance, and 15 min appeared to be sufficient vibro-milling time to provide valuable benefits. (C) 2016 Published by Elsevier Ltd. C1 [Sobolev, Konstantin] Univ Wisconsin, Civil & Environm Engn, Milwaukee, WI 53211 USA. [Lin, Zhibin] N Dakota State Univ, Civil & Environm Engn, Fargo, ND 58102 USA. [Cao, Yizheng; Sun, Hongfang] Purdue Univ Lafayette, Sch Civil Engn, W Lafayette, IN 47907 USA. [Flores-Vivian, Ismael] Univ Autonoma Nuevo Leon, Ave Univ S-N,Cd Univ, San Nicolas De Los Garza 66455, Nuevo Leon, Mexico. [Rushing, Todd; Cummins, Toney] US Army, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Weiss, William Jason] Oregon State Univ, Civil & Construct Engn, 1491 SW Campus Way, Corvallis, OR 97331 USA. RP Sobolev, K (reprint author), Univ Wisconsin, Civil & Environm Engn, Milwaukee, WI 53211 USA. EM sobolev@uwm.edu RI Sobolev, Konstantin/C-9280-2011; UANL, FIC-UANL/O-5444-2015; OI Sobolev, Konstantin/0000-0001-8343-5453; Weiss, William/0000-0003-2859-7980 FU U.S. Army Engineer Research and Development Center [W81EWF93519497-144PRJ35BM] FX The authors acknowledge the financial support of the U.S. Army Engineer Research and Development Center under Cooperative Research Agreement number W81EWF93519497-144PRJ35BM. Permission to publish was granted by Director, Geotechnical and Structures Laboratory. The activation grinding, X-ray Diffraction, and SEM were carried out in the facility of Advanced and Nano-Cement Laboratory (ANCL) at University of Wisconsin-Milwaukee. The remainder of the testing was conducted in Pankow Concrete Laboratory at Purdue University. NR 36 TC 0 Z9 0 U1 3 U2 9 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0958-9465 EI 1873-393X J9 CEMENT CONCRETE COMP JI Cem. Concr. Compos. PD AUG PY 2016 VL 71 BP 53 EP 62 DI 10.1016/j.cemconcomp.2016.04.010 PG 10 WC Construction & Building Technology; Materials Science, Composites SC Construction & Building Technology; Materials Science GA DQ1IP UT WOS:000378955000006 ER PT J AU Dean, RG Houston, JR AF Dean, R. G. Houston, J. R. TI Determining shoreline response to sea level rise SO COASTAL ENGINEERING LA English DT Article DE Sea level rise; Shoreline response; Beach nourishment; Onshore transport; Bruun rule ID ORDER COASTAL CHANGE; BRUUN RULE; SEDIMENT TRANSPORT; EROSION; BUDGET; MODEL; NOURISHMENT; EVOLUTION; BEACHES; RATES AB The Bruun rule is the most widely used method for determining shoreline response to sea level rise. It assumes that the active portion of an offshore profile rises with rising sea level, and the sand required to raise the profile is transported from the shoreline. It is difficult to evaluate the efficacy of the Bruun rule because sea level rise often has a lesser effect on shoreline change than that produced by sand sources, sinks, and longshore transport gradients. In addition, some shorelines have advanced seaward with rising sea level. Dean (1987) showed that equilibrium profile theory predicts that rising sea levels produce landward sand movement forced by nonlinear waves. This paper presents an equation with terms representing all phenomena affecting shoreline change including Bruun-rule recession, onshore sand transport, sand sources and sinks, and longshore transport gradients. As an example of its use, rates of onshore transport are determined along the 275-km Florida southwest coast, USA, and a 19-km portion of this coast using known values for sand sources, sinks, and longshore transport gradients. Then future shoreline changes are projected for both coasts from 2015 to 2065 and for the southwest coast from 2015 to 2100, using sea level rise projections from the Intergovernmental Panel on Climate Change. Beach nourishment is shown to be a very effective adaptation strategy for sea level rise with shoreline change projections useful to estimate required rates of beach nourishment to counter sea level rise. Published by Elsevier B.V. C1 [Dean, R. G.] Univ Florida, Gainesville, FL USA. [Houston, J. R.] Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Houston, JR (reprint author), Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM james.r.houston@usace.army.mil RI wang, baylor09/C-5190-2009 NR 52 TC 1 Z9 1 U1 16 U2 34 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3839 EI 1872-7379 J9 COAST ENG JI Coast. Eng. PD AUG PY 2016 VL 114 BP 1 EP 8 DI 10.1016/j.coastaleng.2016.03.009 PG 8 WC Engineering, Civil; Engineering, Ocean SC Engineering GA DQ1OK UT WOS:000378970100001 ER PT J AU Hutchison, NL Lance, RF Pekins, CE Noble, ME Leberg, PL AF Hutchison, Nicole L. Lance, Richard F. Pekins, Charles E. Noble, Marion E. Leberg, Paul. L. TI Influence of geomorphology and surface features on the genetic structure of an important trogloxene, the secret cave cricket (Ceuthophilus secretus) SO CONSERVATION GENETICS LA English DT Article DE Connectivity; Population genetics; Orthoptera; Resistance; Rhaphidophoridae ID PARTIAL MANTEL TESTS; POPULATION-STRUCTURE; DIFFERENTIATION; ASSIGNMENT; REGRESSION; SOFTWARE; FLOW AB Cave ecosystems supporting a variety of endemics depend on the carbon, nitrogen, and nutrients brought into caves by trogloxenic species, such as the secret cave cricket (Ceuthophilus secretus). Surface movements of trogloxenes may comprise the strongest ecological connections among caves. Our objective was to better understand dispersal patterns in C. secretus in order to inform management of this species and the cave endemics that depend upon them. We used microsatellite loci to estimate gene flow and genetic diversity among 42 karst features supporting C. secretus on the Fort Hood Military Reserve, Texas, USA. This sampling was used to assess the influences of karst topography and other landscape features on genetic diversity and population structure. Cave populations did not exhibit evidence of recent bottlenecks and genetic diversity was similar among sites, with the exception of one sample from an isolated cave. Samples exhibited a strong pattern of isolation by distance, but karst topology was also influential, with genetic differentiation being much higher between samples from separate ridges than among those on the same ridge. It appears that co-location on a ridge was an important factor facilitating dispersal among karst features. There was little evidence that other surface features such as forest cover, roads or streams influenced gene flow and genetic differentiation. The low genetic connectivity among ridges suggests that isolated caves on ridges where cricket habitat is uncommon or degraded might not be easily recolonized after extinction events, with potentially negative consequences for associated cave communities. C1 [Hutchison, Nicole L.; Leberg, Paul. L.] Univ Louisiana Lafayette, Dept Biol, 410 East St Mary Blvd, Lafayette, LA 70504 USA. [Lance, Richard F.] US Army Engn Res & Dev, Environm Lab, Environm Processes Branch, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. [Pekins, Charles E.; Noble, Marion E.] US Army Garrison Ft Hood, Environm Div, Nat Resources Management Branch, 4622 Engn Dr, Ft Hood, TX 76544 USA. RP Leberg, PL (reprint author), Univ Louisiana Lafayette, Dept Biol, 410 East St Mary Blvd, Lafayette, LA 70504 USA. EM Leberg@louisiana.edu FU US Army 6.1 Basic Research Program through ERDC FX We thank many people who assisted with field sampling and logistics, including Zara Environmental LLC (J. Krejca, W. Larsen, J. Larsen), the Fort Hood Natural Resources Branch, and the Leberg Lab at the University of Louisiana at Lafayette (R. Davis, E. Tobin, B. Regime, S. Walter, P. Vasseur). We thank D. Lindsay and S. Bourne, US Army Engineer and Research Development Center (ERDC) Environmental Laboratory, for assistance with manuscript editing and figure production. The manuscript was benefited from the comments of two anonymous reviewers. This research was conducted in conjunction with and funded by US Army 6.1 Basic Research Program through ERDC. Permission was granted by the Chief of Engineers to publish this information. The views expressed in this manuscript are those of the authors and do not reflect the official policy or position of the Department of the Army, Department of Defense, or the U.S. Government. The use of trade, product, or firm names in this paper is for descriptive purposes only and does not imply endorsement by the U.S. Government. NR 44 TC 0 Z9 0 U1 9 U2 9 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1566-0621 EI 1572-9737 J9 CONSERV GENET JI Conserv. Genet. PD AUG PY 2016 VL 17 IS 4 BP 969 EP 983 DI 10.1007/s10592-016-0836-3 PG 15 WC Biodiversity Conservation; Genetics & Heredity SC Biodiversity & Conservation; Genetics & Heredity GA DQ5BX UT WOS:000379220500017 ER PT J AU Gust, KA Kennedy, AJ Melby, NL Wilbanks, MS Laird, J Meeks, B Muller, EB Nisbet, RM Perkins, EJ AF Gust, Kurt A. Kennedy, Alan J. Melby, Nicolas L. Wilbanks, Mitchell S. Laird, Jennifer Meeks, Barbara Muller, Erik B. Nisbet, Roger M. Perkins, Edward J. TI Daphnia magna's sense of competition: intra-specific interactions (ISI) alter life history strategies and increase metals toxicity SO ECOTOXICOLOGY LA English DT Article DE Daphnia; Intra-specific interactions; Ecotoxicology; Metals toxicity; Standard toxicity assays ID ENERGY BUDGET THEORY; INTRASPECIFIC COMPETITION; POPULATIONS; CONSPECIFICS; INDIVIDUALS; SENSITIVITY; INVESTMENT; CHEMICALS; BIOMARKER; RESPONSES AB This work investigates whether the scale-up to multi-animal exposures that is commonly applied in genomics studies provides equivalent toxicity outcomes to single-animal experiments of standard Daphnia magna toxicity assays. Specifically, we tested the null hypothesis that intraspecific interactions (ISI) among D. magna have neither effect on the life history strategies of this species, nor impact toxicological outcomes in exposure experiments with Cu and Pb. The results show that ISI significantly increased mortality of D. magna in both Cu and Pb exposure experiments, decreasing 14 day LC50 s and 95 % confidence intervals from 14.5 (10.9-148.3) to 8.4 (8.2-8.7) A mu g Cu/L and from 232 (156-4810) to 68 (63-73) A mu g Pb/L. Additionally, ISI potentiated Pb impacts on reproduction eliciting a nearly 10-fold decrease in the no-observed effect concentration (from 236 to 25 A mu g/L). As an indication of environmental relevance, the effects of ISI on both mortality and reproduction in Pb exposures were sustained at both high and low food rations. Furthermore, even with a single pair of Daphnia, ISI significantly increased (p < 0.05) neonate production in control conditions, demonstrating that ISI can affect life history strategy. Given these results we reject the null hypothesis and conclude that results from scale-up assays cannot be directly applied to observations from single-animal assessments in D. magna. We postulate that D. magna senses chemical signatures of conspecifics which elicits changes in life history strategies that ultimately increase susceptibility to metal toxicity. C1 [Gust, Kurt A.; Kennedy, Alan J.; Melby, Nicolas L.; Wilbanks, Mitchell S.; Laird, Jennifer; Perkins, Edward J.] US Army, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Meeks, Barbara] SpecPro Tech Serv, San Antonio, TX USA. [Muller, Erik B.] Univ Calif Santa Barbara, Inst Marine Sci, Santa Barbara, CA 93106 USA. [Nisbet, Roger M.] Univ Calif Santa Barbara, Dept Ecol Evolut & Marine Biol, Santa Barbara, CA 93106 USA. RP Gust, KA (reprint author), US Army, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM kurt.a.gust@usace.army.mil RI Nisbet, Roger/B-6951-2014 FU US Army's Environmental Quality and Installations Research Program from the US National Science Foundation; US Environmental Protection Agency [DBI-1266377] FX We thank the anonymous peer reviewers for their assistance in refining the content and presentation of this paper. Opinions, interpretations, conclusions, and recommendations are those of the author(s) and are not necessarily endorsed by the U.S. Army, the National Science Foundation or the U.S. Environmental Protection Agency. This work was supported by the US Army's Environmental Quality and Installations Research Program in addition to partial support to RMN and EBM from the US National Science Foundation and the US Environmental Protection Agency under Cooperative Agreement Number DBI-1266377. NR 33 TC 0 Z9 0 U1 13 U2 18 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0963-9292 EI 1573-3017 J9 ECOTOXICOLOGY JI Ecotoxicology PD AUG PY 2016 VL 25 IS 6 BP 1126 EP 1135 DI 10.1007/s10646-016-1667-1 PG 10 WC Ecology; Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA DQ2KQ UT WOS:000379031600007 PM 27151402 ER PT J AU Ardeljan, M Beyerlein, IJ McWilliams, BA Knezevic, M AF Ardeljan, Milan Beyerlein, Irene J. McWilliams, Brandon A. Knezevic, Marko TI Strain rate and temperature sensitive multi-level crystal plasticity model for large plastic deformation behavior: Application to AZ31 magnesium alloy SO INTERNATIONAL JOURNAL OF PLASTICITY LA English DT Article DE Twinning; Crystal plasticity; Anisotropic material; Finite elements; T-CPFE UMAT ID CRYSTALLOGRAPHIC TEXTURE EVOLUTION; IMPLICIT FINITE-ELEMENTS; X-RAY-DIFFRACTION; POLYCRYSTALLINE HCP/BCC COMPOSITES; ZIRCONIUM SINGLE-CRYSTALS; SITU NEUTRON-DIFFRACTION; PRESSURE-DOUBLE-TORSION; FAST FOURIER-TRANSFORMS; IN-SITU; MECHANICAL RESPONSE AB In this work, we develop a multi-level constitutive model for polycrystalline metals that deform by a combination of elasticity, slip and deformation twinning. It involves a two level homogenization scheme, where the first level uses an upper bound Taylor-type crystal plasticity (T-CP) theory to relate the single-crystal scale to the polycrystal meso-scale and the second level employs an implicit finite elements (FE) approach to relate the meso-scale to the macro-scale. The latter relaxes the iso-strain constraints imposed by the Taylor model. As such, we name the model T-CPFE. At the single crystal level, the model features a dislocation-based hardening law providing the activation stresses that governs slip activity within the single crystals. For deformation twinning, it contains an advancement of a composite grain model that retains the total Lagrangian formulation. Here we use the T-CPFE model to analyze the mechanical response and microstructure evolution of extruded AZ31 Mg alloy samples in simple compression, tension, and torsion under strain rates ranging from 10(-4) s(-1) to 3000 s(-1) and temperatures ranging from 77 K to 423 K reported in Kabirian et al. (2015). Taking the experimentally measured initial texture and average grain size as inputs, the model successfully captures stress-strain responses, deformation texture evolution and twin volume fraction using a single set of material parameters associated with the thermally activated rate laws for dislocation density. The distinctions in flow stress evolution among the loading conditions result from differing relative amounts of slip and twinning activity, which the model internally adjusts based on evolution of slip and twin resistances in the response to the imposed loading conditions. Finally, we show that the T-CPFE model predictions of geometrical changes during compression compare favorably with corresponding geometry of samples deformed experimentally. For this application, it predicts the anisotropy and asymmetry of the material flow resulting from crystallographically soft-to-deform extension twinning and basal slip and hard-to-deform contraction twinning and pyramidal slip. The formulation developed is sufficiently general that the T-CPFE model can be applied to other materials that slip and twin. (C) 2016 Published by Elsevier Ltd. C1 [Ardeljan, Milan; Knezevic, Marko] Univ New Hampshire, Dept Mech Engn, 33 Acad Way,Kingsbury Hall,W119, Durham, NH 03824 USA. [Beyerlein, Irene J.] Los Alamos Natl Lab, Div Theoret, Los Alamos, NM 87545 USA. [McWilliams, Brandon A.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Knezevic, M (reprint author), Univ New Hampshire, Dept Mech Engn, 33 Acad Way,Kingsbury Hall,W119, Durham, NH 03824 USA. EM marko.knezevic@unh.edu FU Army Research Laboratory; Los Alamos National Laboratory Directed Research and Development (LDRD) project [ER20140348] FX This research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-15-2-0084. IJB would like to acknowledge support through a Los Alamos National Laboratory Directed Research and Development (LDRD) project ER20140348. The authors would like to thank Dr. Farhoud Kabirian and Prof. Akhtar S. Khan for supplying the raw data sets from their article. NR 124 TC 3 Z9 3 U1 12 U2 31 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0749-6419 EI 1879-2154 J9 INT J PLASTICITY JI Int. J. Plast. PD AUG PY 2016 VL 83 BP 90 EP 109 DI 10.1016/j.ijplas.2016.04.005 PG 20 WC Engineering, Mechanical; Materials Science, Multidisciplinary; Mechanics SC Engineering; Materials Science; Mechanics GA DQ5YO UT WOS:000379281400006 ER PT J AU Pham, KN Cullen, J Hurwitz, LM Wolff, EM Levie, KE Odem-Davis, K Banerji, JS Rosner, IL Brand, TC L'Esperance, JO Sterbis, JR Porter, CR AF Pham, Khanh N. Cullen, Jennifer Hurwitz, Lauren M. Wolff, Erika M. Levie, Katherine E. Odem-Davis, Katherine Banerji, John S. Rosner, Inger L. Brand, Timothy C. L'Esperance, James O. Sterbis, Joseph R. Porter, Christopher R. TI Prospective Quality of Life in Men Choosing Active Surveillance Compared to Those Biopsied but not Diagnosed with Prostate Cancer SO JOURNAL OF UROLOGY LA English DT Article DE watchful waiting; prostatic neoplasms; quality of life; survival rate; image-guided biopsy ID SF-36 HEALTH SURVEY; RADICAL PROSTATECTOMY; ANXIETY; PREDICTORS; RADIATION; SURVIVORS; DISTRESS; OUTCOMES; BOTHER AB Purpose: Active surveillance is an important alternative to definitive therapy for men with low risk prostate cancer. However, the impact of active surveillance on health related quality of life compared to that in men without cancer remains unknown. In this study we evaluated health related quality of life outcomes in men on active surveillance compared to men followed after negative prostate needle biopsy. Materials and Methods: A prospective study was conducted on men who were enrolled into the Center for Prostate Disease Research Multicenter National Database and underwent prostate needle biopsy for suspicion of prostate cancer between 2007 and 2014. Health related quality of life was assessed at biopsy (baseline) and annually for up to 3 years using SF-36 and EPIC questionnaires. Health related quality of life scores were modeled using generalized estimating equations, adjusting for baseline health related quality of life, and demographic and clinical characteristics. Results: Of the 1,204 men who met the initial eligibility criteria 420 had a negative prostate needle biopsy (noncancer comparison group). Among the 411 men diagnosed with low risk prostate cancer 89 were on active surveillance. Longitudinal analysis revealed that for most health related quality of life subscales there were no significant differences between the groups in adjusted health related quality of life score trends over time. Conclusions: In this study most health related quality of life outcomes in patients with low risk prostate cancer on active surveillance did not differ significantly from those of men without prostate cancer. A comparison group of men with a similar risk of prostate cancer detection is critical to clarify the psychological and physical impact of active surveillance. C1 [Pham, Khanh N.; Wolff, Erika M.; Banerji, John S.; Porter, Christopher R.] Virginia Mason, Seattle, WA USA. [Odem-Davis, Katherine] Ctr Biomed Stat, Seattle, WA USA. [Odem-Davis, Katherine] Inst Translat Hlth Sci, Seattle, WA USA. [Brand, Timothy C.] Madigan Army Med Ctr, Tacoma, WA 98431 USA. [Cullen, Jennifer; Hurwitz, Lauren M.; Levie, Katherine E.; Rosner, Inger L.; Brand, Timothy C.; L'Esperance, James O.; Sterbis, Joseph R.; Porter, Christopher R.] Ctr Prostate Dis Res, Dept Def, Rockville, MD USA. [Cullen, Jennifer; Hurwitz, Lauren M.; Levie, Katherine E.] Uniformed Serv Univ Hlth Sci, Henry M Jackson Fdn Adv Mil Med, Bethesda, MD 20814 USA. [Cullen, Jennifer] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. [Rosner, Inger L.] Walter Reed Natl Mil Med Ctr, Urol Serv, Bethesda, MD USA. [L'Esperance, James O.] Naval Med Ctr San Diego, San Diego, CA USA. [Sterbis, Joseph R.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Cullen, J (reprint author), Uniformed Serv Univ Hlth Sci, 1530 E Jefferson St, Rockville, MD 20852 USA. EM jcullen@cpdr.org FU Uniformed Services University of the Health Sciences [HU0001-10-2-0002]; National Institutes of Health [UL1RR025014]; Center for Prostate Disease Research FX Supported by the Center for Prostate Disease Research and the Uniformed Services University of the Health Sciences (HU0001-10-2-0002), and by the National Institutes of Health (UL1RR025014, to KO-D). NR 30 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-5347 EI 1527-3792 J9 J UROLOGY JI J. Urol. PD AUG PY 2016 VL 196 IS 2 BP 392 EP 398 DI 10.1016/j.juro.2016.02.2972 PG 7 WC Urology & Nephrology SC Urology & Nephrology GA DQ5SX UT WOS:000379266400038 PM 26976206 ER PT J AU Recabal, P Assel, M Musser, JE Caras, RJ Sjoberg, DD Coleman, JA Mulhall, JP Parra, RO Scardino, PT Touijer, K Eastham, JA Laudone, VP AF Recabal, Pedro Assel, Melissa Musser, John E. Caras, Ronald J. Sjoberg, Daniel D. Coleman, Jonathan A. Mulhall, John P. Parra, Raul O. Scardino, Peter T. Touijer, Karim Eastham, James A. Laudone, Vincent P. TI Erectile Function Recovery after Radical Prostatectomy in Men with High Risk Features SO JOURNAL OF UROLOGY LA English DT Article DE prostatic neoplasms; prostatectomy; erectile dysfunction ID POSITIVE SURGICAL MARGINS; EXTRACAPSULAR EXTENSION; INTERNATIONAL INDEX; MORTALITY OUTCOMES; CANCER; RADIOTHERAPY; THERAPY; SELECT; TOOL; MRI AB Purpose: We describe the efficacy of radical prostatectomy to achieve complete primary tumor excision while preserving erectile function in a cohort of patients with high risk features in whom surgical resection was tailored according to clinical staging, biopsy data, preoperative imaging and intraoperative findings. Materials and Methods: In a retrospective review we identified 584 patients with high risk features (prostate specific antigen 20 ng/ml or greater, clinical stage T3 or greater, preoperative Gleason grade 8-10) who underwent radical prostatectomy between 2006 and 2012. The probability of neurovascular bundle preservation was estimated based on preoperative characteristics. Positive surgical margin rates and erectile function recovery were determined in patients who had some degree of neurovascular bundle preservation. Results: The neurovascular bundles were resected bilaterally in 69 (12%) and unilaterally in 91 (16%) patients. The remaining patients had some degree of bilateral neurovascular bundle preservation. Preoperative features associated with a lower probability of neurovascular bundle preservation were primary biopsy Gleason grade 5 and clinical stage T3 disease. Among the patients with some degree of neurovascular bundle preservation 125 of 515 (24%) had a positive surgical margin, and 75 of 160 (47%) men with preoperatively functional erections and available erectile function followup had recovered erectile function within 2 years. Conclusions: High risk features should not be considered an indication for complete bilateral neurovascular bundle resection. Some degree of neurovascular bundle preservation can be done safely by high volume surgeons in the majority of these patients with an acceptable rate of positive surgical margins. Nearly half of high risk patients with functional erections preoperatively recover erectile function after radical prostatectomy. C1 [Recabal, Pedro; Coleman, Jonathan A.; Mulhall, John P.; Parra, Raul O.; Scardino, Peter T.; Touijer, Karim; Eastham, James A.; Laudone, Vincent P.] Mem Sloan Kettering Canc Ctr, Urol Serv, Dept Surg, 1275 York Ave, New York, NY 10065 USA. [Assel, Melissa; Sjoberg, Daniel D.] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA. [Musser, John E.; Caras, Ronald J.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Recabal, Pedro] Fdn Arturo Lopez Perez, Urol Serv, Santiago, Chile. RP Recabal, P (reprint author), Mem Sloan Kettering Canc Ctr, Urol Serv, Dept Surg, 1275 York Ave, New York, NY 10065 USA. EM pedrorecabal@gmail.com OI Recabal, Pedro/0000-0003-4904-0962 FU Sidney Kimmel Center for Prostate and Urologic Cancers; Prostate Cancer Foundation; NIH/NCI Cancer Center [P30 CA008748] FX Supported by the Sidney Kimmel Center for Prostate and Urologic Cancers, David H. Koch through the Prostate Cancer Foundation, and NIH/NCI Cancer Center Support Grant P30 CA008748. NR 22 TC 3 Z9 3 U1 1 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-5347 EI 1527-3792 J9 J UROLOGY JI J. Urol. PD AUG PY 2016 VL 196 IS 2 BP 507 EP 512 DI 10.1016/j.juro.2016.02.080 PG 6 WC Urology & Nephrology SC Urology & Nephrology GA DQ5SX UT WOS:000379266400095 PM 26905018 ER PT J AU Vasil'chuk, YK Lawson, DE Yoshikawa, K Budantseva, NA Chizhova, JN Podborny, YY Vasil'chuk, AC AF Vasil'chuk, Yurij K. Lawson, Daniel E. Yoshikawa, Kenji Budantseva, Nadine A. Chizhova, Julia N. Podborny, Yevgeni Ye. Vasil'chuk, Alla C. TI Stable isotopes in the closed-system Weather Pingo, Alaska and Pestsovoye Pingo, northwestern Siberia SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article DE Pingo; Ice core; Stable isotopes; Alaska; Northwestern Siberia ID WESTERN-ARCTIC-COAST; TUKTOYAKTUK PENINSULA; GROWTH; CANADA; ICE AB High-resolution records of the stable isotopic (delta O-18 and delta D) composition of ice within two closed system (hydrostatic) pingos indicate a complex history of ice formation by segregation and injection and pingo growth. Physical properties and internal structure of continuous ice cores in the center of the Weather Pingo near Prudhoe Bay, Alaska, and the Pestsovoye Pingo, in northwestern Siberia, were described and then sub-sampled for analysis of the isotopic composition. Changes in the isotopic signature and physical properties of ice with depth reveal distinct patterns in both pingos indicative of ice growth as permafrost aggraded into the drained lake basin. In the initial stages following active layer deepening and initial freeze back, in-situ water migrating toward-the freezing front froze at a relatively rapid rate as revealed by a complex isotopic record and small ice crystal size in the cores of Weather Pingo. Once the water supply became limited, freezing under equilibrium-conditions resulted in an isotopic composition consistent with Rayleigh-type fractionation and delta O-18 and delta D values that become more negative with depth. The data for the Pestsovoye Pingo reveal similar trends related to the initial stages of water migration and freezing, followed by isotopic fractionation under equilibrium conditions as unfrozen water available in the talik beneath the pingo became limited. Most of the ice in both pingos (similar to 50%) formed during this final stage of permafrost aggradation. Thus temporal variability in water migration and freezing rate at the base of each pingo created a complex isotopic stratigraphy and ice growth history. (C) 2016 Elsevier B.V. All rights reserved. C1 [Vasil'chuk, Yurij K.; Budantseva, Nadine A.; Chizhova, Julia N.; Vasil'chuk, Alla C.] Lomonosov Moscow State Univ, Leninskie Gory 1, Moscow 119991, Russia. [Lawson, Daniel E.] Dartmouth Coll, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Yoshikawa, Kenji] Univ Alaska, Water & Environm Res Ctr, Inst Northern Engn, Fairbanks, AK 99701 USA. [Podborny, Yevgeni Ye.] Ctr Hydroecol Res, Nalichnaya St,19-A, St Petersburg 199406, Russia. RP Vasil'chuk, YK (reprint author), Lomonosov Moscow State Univ, Leninskie Gory 1, Moscow 119991, Russia. EM vasilch_geo@mail.ru; daniel.e.lawson@dartmouth.edu; kyoshikawa@alaska.edu; nadin.budanceva@mail.ru; eacentr@yandex.ru; epodbornyy@yandex.ru; alla-vasilch@yandex.ru OI Vasil'chuk, Yurij/0000-0001-5847-5568 FU NSF [ARC-0949775]; Russian Science Foundation [14-27-00083]; RFBR [14-05-00930] FX We thank Bruce Brockett for first obtaining the undisturbed ice core, Jerry Brown for logistical support of the drilling operation in 1982, and CRREL, Hanover, NH, for support in storing and maintaining the ice in cold rooms at the temperature required to preserve it. The Institute of Northern Engineering, University of Alaska, Fairbanks, provided grants for travel by Yoshikawa to CRREL. We also thank Tim Howe, Isao Yuguchi and Joel Homan for help with the laboratory analyses. Research funding for Lawson was provided by NSF Grant ARC-0949775. Research funding for Yu.Vasil'chuk, Budantseva and Chizhova was provided by Russian Science Foundation Grant #14-27-00083 and for A.Vasil'chuk, the RFBR Grant #14-05-00930. We thank Drs. Hanno Meyer and Denis Lacelle for their suggestions and insights, which significantly improved this paper. We thank two anonymous reviewers for their comments and criticism that led to improvements in our manuscript. NR 27 TC 0 Z9 0 U1 2 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X EI 1872-7441 J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD AUG PY 2016 VL 128 BP 13 EP 21 DI 10.1016/j.coldregions.2016.05.001 PG 9 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA DQ1JE UT WOS:000378956500002 ER PT J AU Swab, JJ Wright, JC AF Swab, Jeffrey J. Wright, Jared C. TI Application of ASTM C1421 to WC-Co fracture toughness measurement SO INTERNATIONAL JOURNAL OF REFRACTORY METALS & HARD MATERIALS LA English DT Article DE Tungsten carbide; Cemented carbide; Fracture toughness; ASTM 1421; Single-edge precracked beam; Surface crack in flexure ID CEMENTED CARBIDES; INDENTATION FRACTURE; RESIDUAL-STRESSES; HARDNESS; COMPOSITES; HARDMETALS; MECHANICS; EQUATIONS; CERAMICS; CERMETS AB The accurate measurement of fracture toughness of cemented carbides is essential for material development, characterization, and application; however, varying methodologies are used to characterize this critical material property. In this study, the surface crack in flexure and single-edge precracked beam methods in ASTM C1421, along with the Palmqvist indentation/crack length method outlined in ISO 28079, were used to determine the fracture toughness of tungsten carbide (WC) materials containing between 10 and 25 wt.% cobalt (Co). The surface crack in flexure method was not successful because an appropriate precrack did not form underneath the Knoop indentation in any of these compositions. Cracks also did not form at the tips of the Vickers indentations in WC with 15% and higher Co content, rendering the Palmqvist method useless for these materials. The single edge precracked beam method was the only method that yielded consistent and repeatable toughness values for all compositions. Published by Elsevier Ltd. C1 [Swab, Jeffrey J.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Wright, Jared C.] TKC Global, Herndon, VA 20170 USA. [Wright, Jared C.] US Navy NAVAIR NAWCAD, 48,110 Shaw Rd,B2187, Patuxent River, MD 20670 USA. RP Swab, JJ (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM Jeffrey.j.swab.civ@mail.mil FU U.S. Army Research Laboratory [W911QX-14-C-0016] FX The research reported in this manuscript was performed in connection with contract/instrument W911QX-14-C-0016 with the U.S. Army Research Laboratory. The views and conclusions contained in this document are those of TKC Global and the U.S. Army Research Laboratory. Citation of manufacturer's or trade names does not constitute as official endorsement or approval of the use thereof. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon. NR 49 TC 1 Z9 1 U1 3 U2 10 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0263-4368 J9 INT J REFRACT MET H JI Int. J. Refract. Met. Hard Mat. PD AUG PY 2016 VL 58 BP 8 EP 13 DI 10.1016/j.ijrmhm.2016.03.007 PG 6 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA DP3AC UT WOS:000378363800002 ER PT J AU Zhang, SS AF Zhang, Sheng S. TI A new finding on the role of LiNO3 in lithium-sulfur battery SO JOURNAL OF POWER SOURCES LA English DT Article DE Li-S battery; LiNO3; Nitrate; Polysulfide; Redox shuttle ID SOLID-ELECTROLYTE INTERPHASE; LI-S BATTERY; ELECTROCHEMICAL OXIDATION; IONIC LIQUID; NITRATE; DISCHARGE; SHUTTLE; REDUCTION; CHEMISTRY; CAPACITY AB Lithium nitrate (LiNO3) is the most studied additive and co-salt for the electrolyte of lithium-sulfur (Li-S) batteries, its known function is to suppress the redox shuttle of soluble lithium polysulfide (PS, Li2Sn), which reflects as an increase in the battery's coulombic efficiency and cycling stability, as well as a reduced self-discharge rate. The current understanding on this function is that LiNO3 reacts with Li to form a robust surface layer that consequently protects the Li anode from reacting with the dissolved PS. However, little is known on the sulfur cathode except that LiNO3 reduces and adversely affects the battery's performance when the battery is discharged to lower than 1.7 V. In this paper we report a new finding on the role of LiNO3 in enabling the stable cycling of the sulfur cathode. We show that LiNO3 is capable of catalyzing the conversion of high soluble PS to slightly soluble elemental sulfur near the end of charging process, and that the combination of a soluble nitrate in the electrolyte and an insoluble nitrate in the sulfur cathode leads to synergetic improvement. In addition, a possible mechanism is proposed for the catalysis of LiNO3 on the conversion of PS to elemental sulfur. Published by Elsevier B.V. C1 [Zhang, Sheng S.] US Army Res Lab, Electrochem Branch, RDRL SED C, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), US Army Res Lab, Electrochem Branch, RDRL SED C, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. EM shengshui.zhang.civ@mail.mil NR 26 TC 10 Z9 10 U1 66 U2 188 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 EI 1873-2755 J9 J POWER SOURCES JI J. Power Sources PD AUG 1 PY 2016 VL 322 BP 99 EP 105 DI 10.1016/j.jpowsour.2016.05.009 PG 7 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA DO4FO UT WOS:000377737400012 ER PT J AU Ryan, S Li, H Edgerton, M Gallardy, D Cimpoeru, SJ AF Ryan, S. Li, H. Edgerton, M. Gallardy, D. Cimpoeru, S. J. TI The ballistic performance of an ultra-high hardness armour steel: An experimental investigation SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Terminal ballistics; Ultra-high hardness steel; Steel armour; Ballistic armour ID PENETRATION; TARGETS; BEHAVIOR; SHEAR AB The ballistic performance of an ultra-high hardness armour steel (UHA) has been evaluated for a range of thicknesses and obliquities against armour piercing (AP) and fragment simulating projectiles (FSPs). Together with published literature, these results enable the effect of plate hardness on performance against both AP and FSP threats to be characterized over a range of plate hardnesses from similar to 300 to 600 HB. For AP projectiles, a complex relationship was observed that corresponded well with historical phenomenological curves describing the effect of varying projectile and armour failure mechanisms. In the ultra-high hardness regime (> 570 HB), against AP projectiles with core hardnesses of 610-745 HB (i.e. 7.62 mm APM2 and 12.7 mm APM2 projectiles), projectile shatter was demonstrated to be the controlling mechanism of armour performance. Against much softer FSPs (281 HB), where projectile shatter is not a relevant mechanism, the armour performance was found to initially decrease with increasing plate hardness up to similar to 450 HB due to increased susceptibility to adiabatic shear plugging. Above similar to 450 HB the performance was observed to plateau. The observed performance plateau appears to relate to a critical threshold for adiabatic shear failure beyond which further increases in plate hardness will not result in a decrease in performance. A number of common empirical and analytical models were applied to reproduce the experimentally-determined relationship between hardness and penetration resistance, none of which were able to qualitatively or quantitatively reproduce the observed relationships for either projectile class. Crown Copyright (C) 2016 Published by Elsevier Ltd. All rights reserved. C1 [Ryan, S.; Cimpoeru, S. J.] Def Sci & Technol Grp, 506 Lorimer St, Melbourne, Vic 3207, Australia. [Li, H.] Univ Wollongong, Fac Engn & Informat Sci, Wollongong, NSW 2522, Australia. [Li, H.] Def Mat Technol Ctr, 24 Wakefield St, Hawthorn, Vic 3122, Australia. [Edgerton, M.] Univ Queensland, Fac Engn Architecture & Informat Technol, St Lucia, Qld 4072, Australia. [Gallardy, D.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Ryan, S (reprint author), Def Sci & Technol Grp, 506 Lorimer St, Melbourne, Vic 3207, Australia. EM shannon.ryan@dsto.defence.gov.au FU Australian Government's Defence Future Capability Technology Centre (DFCTC) initiative FX The contributions of the Huijin Li of the University of Wollongong and Dake Yu of Bisalloy Steels Pty Ltd. were provided as part of the Defence Materials Technology Centre (DMTC), which was established and is supported by the Australian Government's Defence Future Capability Technology Centre (DFCTC) initiative. NR 27 TC 1 Z9 1 U1 7 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X EI 1879-3509 J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD AUG PY 2016 VL 94 BP 60 EP 73 DI 10.1016/j.ijimpeng.2016.03.011 PG 14 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA DN8JW UT WOS:000377326000006 ER PT J AU Kube, CM AF Kube, Christopher M. TI Attenuation of laser generated ultrasound in steel at high temperatures; comparison of theory and experimental measurements SO ULTRASONICS LA English DT Article DE Ultrasonic attenuation; Laser ultrasound; Process monitoring; Grain size; Additive manufacturing ID ELASTIC-WAVE-PROPAGATION; FREQUENCY SOUND WAVES; POLYCRYSTALLINE MATERIALS; RANDOM-MEDIA; SCATTERING AB This article reexamines some recently published laser ultrasound measurements of the longitudinal attenuation coefficient obtained during annealing of two steel samples (DP600 and S550). Theoretical attenuation models based on perturbation theory are compared to these experimental measurements. It is observed that the Rayleigh attenuation formulas provide the correct qualitative agreement, but overestimate the experimental values. The more general theoretical attenuation model considered here demonstrates strong quantitative agreement, which highlights the applicability of the model during real-time metal processing. (C) 2016 Elsevier B.V. All rights reserved. C1 [Kube, Christopher M.] Army Res Lab, Vehicle Technol Directorate, Mech Div, 4603 Flare Loop, Aberdeen Proving Ground, MD 21005 USA. RP Kube, CM (reprint author), Army Res Lab, Vehicle Technol Directorate, Mech Div, 4603 Flare Loop, Aberdeen Proving Ground, MD 21005 USA. EM christopher.m.kube.ctr@mail.mil NR 18 TC 0 Z9 0 U1 10 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0041-624X EI 1874-9968 J9 ULTRASONICS JI Ultrasonics PD AUG PY 2016 VL 70 BP 238 EP 240 DI 10.1016/j.ultras.2016.05.009 PG 3 WC Acoustics; Radiology, Nuclear Medicine & Medical Imaging SC Acoustics; Radiology, Nuclear Medicine & Medical Imaging GA DN7YG UT WOS:000377295500027 PM 27235777 ER PT J AU Goodin, C Priddy, JD AF Goodin, Christopher Priddy, Jody D. TI Comparison of SPH simulations and cone index tests for cohesive soils SO JOURNAL OF TERRAMECHANICS LA English DT Article DE Cone index; SPH; Mohr-Coulomb ID SMOOTHED PARTICLE HYDRODYNAMICS AB The cone penetrometer test has been used for decades to quantify the soft soil mobility performance of ground vehicles. As physics based methods for modeling soil are developed, it is necessary to validate these simulations against databases relating Cone Index (CI) to vehicle mobility. However, in order to make this comparison, the relationship between the engineering properties of the soil (density, bulk modulus) and the cone index must be determined. To that end, in this work, simulations of cone penetrometer tests in cohesive soil using the smoothed particle hydrodynamics (SPH) method are presented. Three dimensional simulations were conducted and compared to laboratory measurements of cone index in soft soil. The SPH model is parametrized using the elastic moduli of the soil (bulk and shear modulus), the soil density, and the soil cohesion. A novel method which includes skin friction is employed to calculate the forces exerted on the cone tip by the soil. The simulations give good agreement with the measurements, with a coefficient of determination R-2 = 0.76. These results indicate that SPH may be viable for simulating soft soil in conditions relevant for vehicle mobility considerations. Published by Elsevier Ltd. on behalf of ISTVS. C1 [Goodin, Christopher; Priddy, Jody D.] US Army, Geotech & Struct Lab, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. RP Goodin, C (reprint author), US Army, Geotech & Struct Lab, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM christopher.t.goodin@usace.army.mil NR 21 TC 1 Z9 1 U1 5 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4898 EI 1879-1204 J9 J TERRAMECHANICS JI J. Terramech. PD AUG PY 2016 VL 66 BP 49 EP 57 DI 10.1016/j.jterra.2015.09.002 PG 9 WC Engineering, Environmental SC Engineering GA DN7BT UT WOS:000377231000005 ER PT J AU Nie, TT Fang, SC Deng, ZB Lavery, JE AF Nie, Tiantian Fang, Shu-Cherng Deng, Zhibin Lavery, John E. TI On linear conic relaxation of discrete quadratic programs SO OPTIMIZATION METHODS & SOFTWARE LA English DT Article DE discrete quadratic program; linear conic relaxation; RLT method ID SEMIDEFINITE RELAXATION; OPTIMIZATION PROBLEMS; KNAPSACK-PROBLEM; REFORMULATION; GAP AB A special reformulation-linearization technique based linear conic relaxation is proposed for discrete quadratic programming (DQP). We show that the proposed relaxation is tighter than the traditional positive semidefinite programming relaxation. More importantly, when the proposed relaxation problem has an optimal solution with rank one or two, optimal solutions to the original DQP problem can be explicitly generated. This rank-two property is further extended to binary quadratic optimization problems and linearly constrained DQP problems. Numerical results indicate that the proposed relaxation is capable of providing high quality and robust lower bounds for DQP. C1 [Nie, Tiantian; Fang, Shu-Cherng; Lavery, John E.] N Carolina State Univ, Edward P Fitts Dept Ind & Syst Engn, Raleigh, NC 27695 USA. [Deng, Zhibin] Univ Chinese Acad Sci, Sch Management, Beijing 100190, Peoples R China. [Deng, Zhibin] Chinese Acad Sci, Key Lab Big Data Min & Knowledge Management, Beijing 100190, Peoples R China. [Lavery, John E.] Army Res Lab, Div Mat Sci, Army Res Off, Durham, NC 27709 USA. [Lavery, John E.] Army Res Lab, Div Comp Sci, Army Res Off, Durham, NC 27709 USA. RP Deng, ZB (reprint author), Univ Chinese Acad Sci, Sch Management, Beijing 100190, Peoples R China.; Deng, ZB (reprint author), Chinese Acad Sci, Key Lab Big Data Min & Knowledge Management, Beijing 100190, Peoples R China. EM zhibindeng@ucas.ac.cn FU US Army Research Office [W911NF-15-1-0223]; Edward P. Fitts Fellowship of the North Carolina State University; Scientific Research Foundation of the University of Chinese Academy of Sciences [Y551037Y00]; National Natural Science Foundation of China [11501543] FX This work was supported by US Army Research Office [W911NF-15-1-0223], Edward P. Fitts Fellowship of the North Carolina State University, Scientific Research Foundation of the University of Chinese Academy of Sciences [Y551037Y00] and the National Natural Science Foundation of China [11501543]. NR 28 TC 0 Z9 0 U1 2 U2 2 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 1055-6788 EI 1029-4937 J9 OPTIM METHOD SOFTW JI Optim. Method Softw. PD AUG PY 2016 VL 31 IS 4 BP 737 EP 754 DI 10.1080/10556788.2015.1134528 PG 18 WC Computer Science, Software Engineering; Operations Research & Management Science; Mathematics, Applied SC Computer Science; Operations Research & Management Science; Mathematics GA DN5XQ UT WOS:000377145400005 ER PT J AU Stockdale, TA Strawhecker, KE Sandoz-Rosado, EJ Wetzel, ED AF Stockdale, Taylor A. Strawhecker, Kenneth E. Sandoz-Rosado, Emil J. Wetzel, Eric D. TI A rapid FIB-notch technique for characterizing the internal morphology of high-performance fibers SO MATERIALS LETTERS LA English DT Article DE Focused ion beam; Atomic force microscopy; Morphology; High-performance fiber; Kevlar; Ultra-high-molecular-weight polyethylene ID ATOMIC-FORCE MICROSCOPY; POLY(PARA-PHENYLENE TEREPHTHALAMIDE) FIBERS; MOLECULAR-WEIGHT; MODULUS; KEVLAR AB This work introduces an innovative technique to characterize the internal morphology of high-performance fibers by using a focused ion beam (FIB) sample preparation method and subsequent atomic force microscopy (AFM). A FIB is used to mill opposing notches that facilitate direct failure along a longitudinal shear plane, and expose the internal surface of the fiber. By exposing this surface via longitudinal shear, distortion of the cleaved surface is minimal, which is an advantage over surface preparation methods such as microtoming. After cleaving the notched fibers, an AFM technique is used to generate modulus maps of the fiber fracture surfaces. These modulus maps provide qualitative and quantitative micro structural information. Initial results obtained from Kevlar KM2 and Dyneema SK76 fibers are presented and a brief analysis of the observed internal features is provided. Extending the technique to image internal features in other materials is also discussed. Published by Elsevier B.V. C1 [Stockdale, Taylor A.; Strawhecker, Kenneth E.; Sandoz-Rosado, Emil J.; Wetzel, Eric D.] US Army, Mat & Mfg Sci Div, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Stockdale, Taylor A.] Univ Nebraska, Mech & Mat Engn Dept, Lincoln, NE 68588 USA. RP Strawhecker, KE (reprint author), US Army, Mat & Mfg Sci Div, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM kenneth.e.strawhecker.civ@mail.mil FU College Qualified Leaders program through the American Society for Engineering Education [W911SR-15-2-0001] FX The authors would like to gratefully acknowledge Dr. Yuris Dzenis for helpful suggestions, revisions, and insight during the writing of this paper. Funding for this work was provided by the College Qualified Leaders program through the American Society for Engineering Education (Contract W911SR-15-2-0001). Also, the authors acknowledge Dr. Jon Ligda for providing training on the SEM/FIB system at ARL. NR 21 TC 3 Z9 3 U1 1 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-577X EI 1873-4979 J9 MATER LETT JI Mater. Lett. PD AUG 1 PY 2016 VL 176 BP 173 EP 176 DI 10.1016/j.matlet.2016.04.082 PG 4 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA DL7XD UT WOS:000375852800044 ER PT J AU Crowell, TA Phanuphak, N Pinyakorn, S Kroon, E Fletcher, JLK Colby, D Tipsuk, S Karnsomlap, P Laopraynak, N O'Connell, RJ Robb, ML Ananworanich, J AF Crowell, Trevor A. Phanuphak, Nittaya Pinyakorn, Suteeraporn Kroon, Eugene Fletcher, James L. K. Colby, Donn Tipsuk, Somporn Karnsomlap, Putthachard Laopraynak, Naphassanant O'Connell, Robert J. Robb, Merlin L. Ananworanich, Jintanat CA RV254 SEARCH010 Study Grp TI Virologic failure is uncommon after treatment initiation during acute HIV infection SO AIDS LA English DT Article DE acute HIV; highly active antiretroviral therapy; HIV; viral load; virologic failure ID COMBINATION ANTIRETROVIRAL THERAPY; OPEN-LABEL; EFFICACY; REGIMEN; RESERVOIR; SIZE AB Objective: In chronic HIV infection, initiation of antiretroviral therapy (ART) typically induces swift HIV RNA declines and virologic suppression within 24 weeks. The objective of this study was to investigate viral dynamics and common criteria for treatment success after ART initiation during acute HIV infection (AHI). Methods: Participants were prospectively enrolled and offered ART during AHI from May 2009-June 2015 in Bangkok, Thailand. Regimens included tenofovir, lamivudine or emtricitabine, and efavirenz with or without raltegravir and maraviroc. Participants were monitored for several HIV RNA end points: one-log reduction at week 2; two-log reduction at week 4; less than 1000 copies/ml at week 24; and less than 200 copies/ml at week 24. Factors associated with each end point, time to suppression, and virologic blips were explored. Results: Two hundred and sixty-four Thai participants initiated ART during AHI. Their median age was 27 years and 96% were men. At 2 weeks, 6.5% had not achieved a one-log reduction in HIV RNA. At 4 weeks, 11.0% had not achieved a two-log reduction. At 24 weeks, 1.1% had not achieved HIV RNA less than 1000 copies/ml and 1.5% had not achieved HIV RNA less than 200 copies/ml. Participants who initiated ART during Fiebig I demonstrated a shorter median time to virologic suppression than did all other stages combined, [4 (interquartile range 2-8) vs. 8 (interquartile range 4-12) weeks, P < 0.001] and 7.3% had subsequent blips (16.1% in other stages, P = 0.23). Conclusion: Virologic failure is uncommon in individuals who initiate ART during AHI. ART initiation during AHI is efficacious and clinicians can monitor for virologic failure after 24 weeks of therapy. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved. C1 [Crowell, Trevor A.; Pinyakorn, Suteeraporn; Robb, Merlin L.; Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Crowell, Trevor A.; Pinyakorn, Suteeraporn; Robb, Merlin L.; Ananworanich, Jintanat] Henry M Jackson Fdn Advancement Mil Med, Bethesda, MD USA. [Phanuphak, Nittaya; Kroon, Eugene; Fletcher, James L. K.; Colby, Donn; Tipsuk, Somporn; Karnsomlap, Putthachard; Ananworanich, Jintanat] SEARCH, Bangkok, Thailand. [Laopraynak, Naphassanant] Thai Red Cross AIDS Res Ctr, HIV NAT, Bangkok, Thailand. [O'Connell, Robert J.] Armed Forces Res Inst Med Sci, Bangkok, Thailand. RP Crowell, TA (reprint author), US Mil HIV Res Program, 6720A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA. EM tcrowell@hivresearch.org FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067, W81XWH-11-2-0174]; US Department of the Army [W81XWH-07-2-0067, W81XWH-11-2-0174]; Thai Government Pharmaceutical Organization (GPO); Gilead; Merck; Pfizer FX This work was supported by cooperative agreements (W81XWH-07-2-0067, W81XWH-11-2-0174) between The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the US Department of the Army. ART was supported by the Thai Government Pharmaceutical Organization (GPO), Gilead, Merck and Pfizer. NR 25 TC 0 Z9 0 U1 3 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0269-9370 EI 1473-5571 J9 AIDS JI Aids PD JUL 31 PY 2016 VL 30 IS 12 BP 1943 EP 1950 DI 10.1097/QAD.0000000000001148 PG 8 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA DR6MK UT WOS:000380015800011 PM 27163706 ER PT J AU Bui, N Meshot, ER Kim, S Pena, J Gibson, PW Wu, KJ Fornasiero, F AF Ngoc Bui Meshot, Eric R. Kim, Sangil Pena, Jose Gibson, Phillip W. Wu, Kuang Jen Fornasiero, Francesco TI Ultrabreathable and Protective Membranes with Sub-5 nm Carbon Nanotube Pores SO ADVANCED MATERIALS LA English DT Article ID FAST WATER TRANSPORT; FAST MASS-TRANSPORT; BIOLOGICAL PROTECTION; BREATHABLE MEMBRANES; DIFFUSION; FLOW; FABRICS; FLUX; PERFORMANCE; SELECTIVITY AB Small-diameter carbon nanotubes (CNTs) are shown to enable exceptionally fast transport of water vapor under a concentration gradient driving force. Thanks to this property, membranes having sub-5 nm CNTs as conductive pores feature outstanding breathability while maintaining a high degree of protection from biothreats by size exclusion. C1 [Ngoc Bui; Meshot, Eric R.; Kim, Sangil; Pena, Jose; Wu, Kuang Jen; Fornasiero, Francesco] Lawrence Livermore Natl Lab, Phys & Life Sci, Livermore, CA 94550 USA. [Gibson, Phillip W.] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. RP Fornasiero, F (reprint author), Lawrence Livermore Natl Lab, Phys & Life Sci, Livermore, CA 94550 USA. EM fornasiero1@llnl.gov RI Gibson, Phillip/D-2398-2010 OI Gibson, Phillip/0000-0002-6172-4438 FU Chemical and Biological Technologies Department of the Defense Threat Reduction Agency (DTRA-CB) [BA12PHM123]; Laboratory Directed Research and Development Program at LLNL [13-ERD-030]; US Department of Energy [DE-AC52-07NA27344]; Office of Science, Office of Basic Energy Sciences, of the US Department of Energy [DE-AC02-05CH11231]; Office of Science, Office of Basic Energy Sciences, of the U.S. Department of Energy [DE-AC02-05CH11231] FX This work was enabled by financial support from the Chemical and Biological Technologies Department of the Defense Threat Reduction Agency (DTRA-CB) via grant BA12PHM123 in the "Dynamic Multifunctional Materials for a Second Skin D[MS]2" program. F.F. acknowledges partial support from the Laboratory Directed Research and Development Program at LLNL under project tracking code 13-ERD-030. Work at LLNL was performed under the auspices of the US Department of Energy under contract DE-AC52-07NA27344. A portion of this work was performed at the Molecular Foundry, which was supported by the Office of Science, Office of Basic Energy Sciences, of the US Department of Energy under contract DE-AC02-05CH11231. X-ray characterization was performed at Beamline 7.3.3 of the Advanced Light Source, which was supported by the Director of the Office of Science, Office of Basic Energy Sciences, of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. NR 75 TC 0 Z9 0 U1 25 U2 25 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 0935-9648 EI 1521-4095 J9 ADV MATER JI Adv. Mater. PD JUL 27 PY 2016 VL 28 IS 28 BP 5871 EP + DI 10.1002/adma.201600740 PG 8 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA DU7NJ UT WOS:000382400900010 PM 27159328 ER PT J AU Akogwu, I Wang, N Zhang, CY Gong, P AF Akogwu, Isaac Wang, Nan Zhang, Chaoyang Gong, Ping TI A comparative study of k-spectrum-based error correction methods for next-generation sequencing data analysis SO HUMAN GENOMICS LA English DT Article DE Next-generation sequencing (NGS); k-mer; k-spectrum; Error correction; Sequence analysis; Bloom filter ID BURROWS-WHEELER TRANSFORM; PAIRED READS; ALGORITHMS AB Background: Innumerable opportunities for new genomic research have been stimulated by advancement in high-throughput next-generation sequencing (NGS). However, the pitfall of NGS data abundance is the complication of distinction between true biological variants and sequence error alterations during downstream analysis. Many error correction methods have been developed to correct erroneous NGS reads before further analysis, but independent evaluation of the impact of such dataset features as read length, genome size, and coverage depth on their performance is lacking. This comparative study aims to investigate the strength and weakness as well as limitations of some newest k-spectrum-based methods and to provide recommendations for users in selecting suitable methods with respect to specific NGS datasets. Methods: Six k-spectrum-based methods, i.e., Reptile, Musket, Bless, Bloocoo, Lighter, and Trowel, were compared using six simulated sets of paired-end Illumina sequencing data. These NGS datasets varied in coverage depth (10x to 120x), read length (36 to 100 bp), and genome size (4.6 to 143 MB). Error Correction Evaluation Toolkit (ECET) was employed to derive a suite of metrics (i.e., true positives, false positive, false negative, recall, precision, gain, and F-score) for assessing the correction quality of each method. Results: Results from computational experiments indicate that Musket had the best overall performance across the spectra of examined variants reflected in the six datasets. The lowest accuracy of Musket (F-score = 0.81) occurred to a dataset with a medium read length (56 bp), a medium coverage (50x), and a small-sized genome (5.4 MB). The other five methods underperformed (F-score < 0.80) and/or failed to process one or more datasets. Conclusions: This study demonstrates that various factors such as coverage depth, read length, and genome size may influence performance of individual k-spectrum-based error correction methods. Thus, efforts have to be paid in choosing appropriate methods for error correction of specific NGS datasets. Based on our comparative study, we recommend Musket as the top choice because of its consistently superior performance across all six testing datasets. Further extensive studies are warranted to assess these methods using experimental datasets generated by NGS platforms (e.g., 454, SOLiD, and Ion Torrent) under more diversified parameter settings (k-mer values and edit distances) and to compare them against other non-k-spectrum-based classes of error correction methods. C1 [Akogwu, Isaac; Wang, Nan; Zhang, Chaoyang] Univ Southern Mississippi, Sch Comp, Hattiesburg, MS 39406 USA. [Gong, Ping] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Gong, P (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. EM Ping.Gong@usace.army.mil FU National Science Foundation award [EPS 0903787]; US Army Environmental Quality/Installation (EQI) Basic Research Program FX This work was supported by a National Science Foundation award (EPS 0903787) to CZ and NW and an intramural grant from the US Army Environmental Quality/Installation (EQI) Basic Research Program to PG. Permission was granted by the Chief of Engineer to publish this paper. NR 41 TC 1 Z9 1 U1 3 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1473-9542 EI 1479-7364 J9 HUM GENOMICS JI Hum. Genomics PD JUL 25 PY 2016 VL 10 SU 2 AR 20 DI 10.1186/s40246-016-0068-0 PG 11 WC Genetics & Heredity SC Genetics & Heredity GA DW5LN UT WOS:000383686800004 PM 27461106 ER PT J AU Goldberg, L Cole, B McIntosh, C King, V Hays, AD Chinn, SR AF Goldberg, Lew Cole, Brian McIntosh, Chris King, Vernon Hays, A. D. Chinn, Stephen R. TI Narrow-band 1 W source at 257 nm using frequency quadrupled passively Q-switched Yb:YAG laser SO OPTICS EXPRESS LA English DT Article ID SOLID-STATE LASER; 4TH-HARMONIC GENERATION; HIGH-POWER; UV; EXPLOSIVES AB We describe generation of 1.1 W of 257 nm emission by frequency quadrupling the 1030 nm emission from a compact passively Q-switched Yb:YAG laser. The laser utilized a volume Bragg grating to achieve a 0.1 nm linewidth required for UV-Raman spectroscopic applications, generated 100 kW peak power, 250 mu J pulses and 3.6 W of average power at 1030 nm. Fourth harmonic generation (FHG) was carried out using a 10 mm lithium triborate (LBO) crystal to generate 515 nm second harmonic with 70% conversion efficiency, followed by a 7 mm beta-barium borate (BBO) crystal to generate 257 nm fourth harmonic with 45% efficiency, resulting in an overall nonlinear conversion e ffi ciency of 31%. Far-field and near-field of the FHG emission were characterized. (C) 2016 Optical Society of America C1 [Goldberg, Lew; Cole, Brian; McIntosh, Chris; King, Vernon; Hays, A. D.] US Army, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA 22060 USA. [Chinn, Stephen R.] Fulcrum Inc, 5870 Trinity Pkwy, Centerville, VA 20120 USA. RP King, V (reprint author), US Army, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA 22060 USA. EM info@nvl.army.mil NR 25 TC 0 Z9 0 U1 5 U2 5 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD JUL 25 PY 2016 VL 24 IS 15 BP 17397 EP 17405 DI 10.1364/OE.24.017397 PG 9 WC Optics SC Optics GA DX9LB UT WOS:000384715800113 PM 27464186 ER PT J AU Chabot, DJ Ribot, WJ Joyce, J Cook, J Hepler, R Nahas, D Chua, J Friedlander, AM AF Chabot, Donald J. Ribot, Wilson J. Joyce, Joseph Cook, James Hepler, Robert Nahas, Debbie Chua, Jennifer Friedlander, Arthur M. TI Protection of rhesus macaques against inhalational anthrax with a Bacillus anthracis capsule conjugate vaccine SO VACCINE LA English DT Article DE Anthrax; Vaccine; Capsule; Conjugate; Polyglutamate; Rhesus macaque ID GUINEA-PIGS; IMMUNOGENICITY; INFECTION; EFFICACY; RESPONSES; ANTIGEN; RABBITS; ACID; MICE AB The efficacy of currently licensed anthrax vaccines is largely attributable to a single Bacillus anthracis immunogen, protective antigen. To broaden protection against possible strains resistant to protective antigen-based vaccines, we previously developed a vaccine in which the anthrax polyglutamic acid capsule was covalently conjugated to the outer membrane protein complex of Neisseria meningitidis serotype B and demonstrated that two doses of 2.5 mu g of this vaccine conferred partial protection of rhesus macaques against inhalational anthrax. Here, we demonstrate complete protection of rhesus macaques against inhalational anthrax with a higher 50 mu g dose of the same capsule conjugate vaccine. These results indicate that B. anthracis capsule is a highly effective vaccine component that should be considered for incorporation in future generation anthrax vaccines. Published by Elsevier Ltd. C1 [Chabot, Donald J.; Ribot, Wilson J.; Chua, Jennifer; Friedlander, Arthur M.] US Army, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. [Joyce, Joseph; Cook, James; Hepler, Robert; Nahas, Debbie] Merck & Co Inc, Kenilworth, NJ USA. [Friedlander, Arthur M.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. RP Friedlander, AM (reprint author), US Army, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM donald.j.chabot.ctr@mail.mil; wilson.j.ribot.civ@mail.mil; Joseph_Joyce@Merck.com; James_Cook@merck.com; rhepler2@its.jnj.com; debbie_nahas@merck.com; Jennifer.chua.ctr@mail.mil; arthur.m.friedlander.civ@mail.mil FU Medical Biological Defense Research Program, U.S. Army Medical Research and Materiel Command [921175] FX This work was supported by the Medical Biological Defense Research Program, U.S. Army Medical Research and Materiel Command. Project No. 921175. NR 25 TC 0 Z9 0 U1 5 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD JUL 25 PY 2016 VL 34 IS 34 BP 4012 EP 4016 DI 10.1016/j.vaccine.2016.06.031 PG 5 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA DS2MQ UT WOS:000380604000015 PM 27329184 ER PT J AU Sharar, DJ Bergles, AE Jankowski, NR Bar-Cohen, A AF Sharar, Darin J. Bergles, Arthur E. Jankowski, Nicholas R. Bar-Cohen, Avram TI Nonintrusive Optical Validation of Two-Phase Flow Regimes in a Small-Diameter Tube SO HEAT TRANSFER ENGINEERING LA English DT Article; Proceedings Paper CT 12th International Conference on Nanochannels, Microchannels and Minichannels (ICNMM) CY AUG 03-07, 2014 CL Chicago, IL SP Amer Soc Mech Engineers, Fluids Engn Div ID LIQUID-FILM THICKNESS; HORIZONTAL TUBES; PATTERN MAP; PART I; HEAT-TRANSFER; MICROCHANNELS; VISUALIZATION; EVAPORATION; SMOOTH AB While the majority of studies examining the relationship between flow regime and thermofluid performance rely on subjective flow regime determination, objective techniques are needed to more firmly establish the nature and repeatability of these phenomena. This study describes a nonintrusive optical flow regime characterization methodology used to study horizontal, adiabatic, two-phase flow of water-water vapor and water-nitrogen gas in small (8.84mm) diameter tubes. The method relies on shining a fiber-optic light source through the top of a borosilicate glass tube at the outlet of a smooth copper tube, using a CMOS camera to capture light rings resulting from total internal reflection at the liquid-vapor interface, and extracting a film thickness profile from successive images. Using these unique temporally varying film profiles, quantitative identification measures were developed for the primary flow regimes, including the ability to explain and quantify the more subtle transitions that exist between dominant regimes as the two-phase flows progress from saturated liquid to qualities of 0.32. Application of this methodology has shown the Taitel-Dukler, Ullmann-Brauner, and Wojtan etal. phenomenological flow regime maps to capture the salient features and transition boundaries, with varying accuracy, for small-diameter two-phase flow in a mass flux range of 15 to 230kg/m(2)-s. C1 [Sharar, Darin J.; Jankowski, Nicholas R.] Gen Tech Serv LLC, Wall, NJ USA. [Bergles, Arthur E.; Bar-Cohen, Avram] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. RP Sharar, DJ (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM darin.j.sharar.ctr@mail.mil NR 35 TC 0 Z9 0 U1 5 U2 35 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0145-7632 EI 1521-0537 J9 HEAT TRANSFER ENG JI Heat Transf. Eng. PD JUL 23 PY 2016 VL 37 IS 11 SI SI BP 972 EP 984 DI 10.1080/01457632.2015.1098267 PG 13 WC Thermodynamics; Engineering, Mechanical; Mechanics SC Thermodynamics; Engineering; Mechanics GA DE9OL UT WOS:000370967300008 ER PT J AU Vetor, R Murray, CK Mende, K Melton-Kreft, R Akers, KS Wenke, J Spirk, T Guymon, C Zera, W Beckius, ML Schnaubelt, ER Ehrlich, G Vento, TJ AF Vetor, Ryan Murray, Clinton K. Mende, Katrin Melton-Kreft, Rachel Akers, Kevin S. Wenke, Joseph Spirk, Tracy Guymon, Charles Zera, Wendy Beckius, Miriam L. Schnaubelt, Elizabeth R. Ehrlich, Garth Vento, Todd J. TI The use of PCR/Electrospray Ionization-Time-of-Flight-Mass Spectrometry (PCR/ESI-TOF-MS) to detect bacterial and fungal colonization in healthy military service members SO BMC INFECTIOUS DISEASES LA English DT Article DE Colonization; Bacterial; Fungal; Molecular diagnostics; Military; PCR; Electrospray ionization time-of-flight mass spectrometry ID GROUP-B STREPTOCOCCI; SUSCEPTIBLE STAPHYLOCOCCUS-AUREUS; HOST-PATHOGEN INTERACTIONS; HUMAN ORAL MICROBIOME; NASAL CARRIAGE; NASOPHARYNGEAL CARRIAGE; METHICILLIN-RESISTANT; RAPID IDENTIFICATION; JOINT INFECTION; LATE PREGNANCY AB Background: The role of microbial colonization in disease is complex. Novel molecular tools to detect colonization offer theoretical improvements over traditional methods. We evaluated PCR/Electrospray Ionization-Time-of-Flight-Mass Spectrometry (PCR/ESI-TOF-MS) as a screening tool to study colonization of healthy military service members. Methods: We assessed 101 healthy Soldiers using PCR/ESI-TOF-MS on nares, oropharynx, and groin specimens for the presence of gram-positive and gram-negative bacteria (GNB), fungi, and antibiotic resistance genes. A second set of swabs was processed by traditional culture, followed by identification using the BD Phoenix automated system; comparison between PCR/ESI-TOF-MS and culture was carried out only for GNB. Results: Using PCR/ESI-TOF-MS, at least one colonizing organism was found on each individual: mean (SD) number of organisms per subject of 11.8(2.8). The mean number of organisms in the nares, groin and oropharynx was 3.8(1.3), 3.8(1.4) and 4.2(2), respectively. The most commonly detected organisms were aerobic gram-positive bacteria: primarily coagulase-negative Staphylococcus (101 subjects: 341 organisms), Streptococcus pneumoniae (54 subjects: 57 organisms), Staphylococcus aureus (58 subjects: 80 organisms) and Nocardia asteroides (45 subjects: 50 organisms). The mecA gene was found in 96 subjects. The most commonly found GNB was Haemophilus influenzae (20 subjects: 21 organisms) and the most common anaerobe was Propionibacterium acnes (59 subjects). Saccharomyces species (30 subjects) were the most common fungi detected. Only one GNB (nares E. coli) was identified in the same subject by both diagnostic systems. Conclusion: PCR/ESI-TOF-MS detected common colonizing organisms and identified more typically-virulent bacteria in asymptomatic, healthy adults. PCR/ESI-TOF-MS appears to be a useful method for detecting bacterial and fungal organisms, but further clinical correlation and validation studies are needed. C1 [Vetor, Ryan; Murray, Clinton K.; Mende, Katrin; Zera, Wendy; Beckius, Miriam L.; Vento, Todd J.] San Antonio Mil Med Ctr, San Antonio, TX 78219 USA. [Murray, Clinton K.; Akers, Kevin S.; Vento, Todd J.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Mende, Katrin; Zera, Wendy] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Melton-Kreft, Rachel; Spirk, Tracy; Ehrlich, Garth] Allegheny Singer Res Inst, Ctr Genom Sci, 320 E N Ave, Pittsburgh, PA 15212 USA. [Akers, Kevin S.; Wenke, Joseph; Guymon, Charles] US Army, Inst Surg Res, San Antonio, TX USA. [Schnaubelt, Elizabeth R.] Landstuhl Reg Med Ctr, Landstuhl, Germany. [Vento, Todd J.] Brooke Army Med Ctr, Infect Dis Serv, MCHE MDI, 3551 Roger Brooke Dr, JBSA Ft Sam Houston, TX 78234 USA. RP Vento, TJ (reprint author), San Antonio Mil Med Ctr, San Antonio, TX 78219 USA.; Vento, TJ (reprint author), Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. EM todd.j.vento.mil@mail.mil FU Armed Forces Health Surveillance Center; Global Emerging Infections Surveillance and Response System; Allegheny Singer Research Institute of the Allegheny Health Network FX This work was supported by the Armed Forces Health Surveillance Center including the Global Emerging Infections Surveillance and Response System, and Allegheny Singer Research Institute of the Allegheny Health Network. NR 41 TC 0 Z9 0 U1 4 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD JUL 22 PY 2016 VL 16 AR 338 DI 10.1186/s12879-016-1651-7 PG 12 WC Infectious Diseases SC Infectious Diseases GA DS6KZ UT WOS:000380892000001 PM 27448413 ER PT J AU Liu, PW Jin, Z Katsukis, G Drahushuk, LW Shimizu, S Shih, CJ Wetzel, ED Taggart-Scarff, JK Qing, B Van Vliet, KJ Li, R Wardle, BL Strano, MS AF Liu, Pingwei Jin, Zhong Katsukis, Georgios Drahushuk, Lee William Shimizu, Steven Shih, Chih-Jen Wetzel, Eric D. Taggart-Scarff, Joshua K. Qing, Bo Van Vliet, Krystyn J. Li, Richard Wardle, Brian L. Strano, Michael S. TI Layered and scrolled nanocomposites with aligned semi-infinite graphene inclusions at the platelet limit SO SCIENCE LA English DT Article ID CHEMICAL-VAPOR-DEPOSITION; LARGE-AREA; POLYMER NANOCOMPOSITES; COMPOSITES; POLYCARBONATE; STIFFNESS; DESIGN; FILMS AB Two-dimensional (2D) materials can uniquely span the physical dimensions of a surrounding composite matrix in the limit of maximum reinforcement. However, the alignment and assembly of continuous 2D components at high volume fraction remain challenging. We use a stacking and folding method to generate aligned graphene/polycarbonate composites with as many as 320 parallel layers spanning 0.032 to 0.11 millimeters in thickness that significantly increases the effective elastic modulus and strength at exceptionally low volume fractions of only 0.082%. An analogous transverse shear scrolling method generates Archimedean spiral fibers that demonstrate exotic, telescoping elongation at break of 110%, or 30 times greater than Kevlar. Both composites retain anisotropic electrical conduction along the graphene planar axis and transparency. These composites promise substantial mechanical reinforcement, electrical, and optical properties at highly reduced volume fraction. C1 [Liu, Pingwei; Jin, Zhong; Katsukis, Georgios; Drahushuk, Lee William; Shimizu, Steven; Shih, Chih-Jen; Strano, Michael S.] MIT, Dept Chem Engn, Cambridge, MA 02139 USA. [Jin, Zhong] Nanjing Univ, Key Lab Mesoscop Chem MOE, Nanjing 210093, Jiangsu, Peoples R China. [Jin, Zhong] Nanjing Univ, Sch Chem & Chem Engn, Collaborat Innovat Ctr Chem Life Sci, Nanjing 210093, Jiangsu, Peoples R China. [Wetzel, Eric D.; Taggart-Scarff, Joshua K.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Qing, Bo; Van Vliet, Krystyn J.] MIT, Dept Biol Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA. [Van Vliet, Krystyn J.] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA. [Li, Richard; Wardle, Brian L.] MIT, Dept Aeronaut & Astronaut, Cambridge, MA 02139 USA. RP Strano, MS (reprint author), MIT, Dept Chem Engn, Cambridge, MA 02139 USA. EM strano@mit.edu RI Jin, Zhong/D-1742-2012; Shih, Chih-Jen/O-6783-2016 OI Jin, Zhong/0000-0001-8860-8579; Shih, Chih-Jen/0000-0002-5258-3485 FU U.S. Office of Naval Research Multidisciplinary University Research Initiatives (MURI) grant on Graphene Approaches to Terahertz Electronics (GATE) at Massachusetts Institute of Technology (MIT), Harvard University; Boston University; U.S. Army Research Laboratory (ARL); U.S. Army Research Office (ARO) through the Institute for Soldier Nanotechnologies (ISN) [W911NF-13-D-0001]; NASA Space Technology Research Fellowship (NSTRF); National Defense Science and Engineering Graduate (NDSEG) Fellowship; ISN at MIT - U.S. ARO; MIT Department of Materials Science and Engineering NanoLab FX This work was primarily funded by 2009 U.S. Office of Naval Research Multidisciplinary University Research Initiatives (MURI) grant on Graphene Approaches to Terahertz Electronics (GATE) at Massachusetts Institute of Technology (MIT), Harvard University, and Boston University. This work was also supported in part by the U.S. Army Research Laboratory (ARL) and the U.S. Army Research Office (ARO) through the Institute for Soldier Nanotechnologies (ISN), under contract number W911NF-13-D-0001. R.L. is supported by a NASA Space Technology Research Fellowship (NSTRF), and B.Q. is supported by a National Defense Science and Engineering Graduate (NDSEG) Fellowship. We appreciate characterization support from the ISN at MIT funded by U.S. ARO and MIT Department of Materials Science and Engineering NanoLab. We also thank A. Schwartzman (MIT NanoLab) for the microindentation and uniaxial tensile test of 4j samples; P. Moy and V. Wu of ARL for the imaging of the scrolled fibers in the tensile test; and E. Cohen for careful review of the manuscript and differential scanning calorimetry/dynamic mechanical analysis data. NR 29 TC 4 Z9 4 U1 84 U2 110 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 0036-8075 EI 1095-9203 J9 SCIENCE JI Science PD JUL 22 PY 2016 VL 353 IS 6297 BP 364 EP 367 DI 10.1126/science.aaf4362 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DS2HB UT WOS:000380583400035 PM 27463667 ER PT J AU Li, Z Zhao, P Tofighi, S Sharma, R Ensley, TR Jang, SH Hagan, DJ Van Stryland, EW Jen, AKY AF Li, Zhong'an Zhao, Peng Tofighi, Salimeh Sharma, Rajesh Ensley, Trenton R. Jang, Sei-Hum Hagan, David J. Van Stryland, Eric W. Jen, Alex K. -Y. TI Zwitterionic Cyanine-Cyanine Salt: Structure and Optical Properties SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID POLYMETHINE DYES; TELECOMMUNICATION WAVELENGTHS; SWITCHING APPLICATIONS; SQUARAINE DYES; NONLINEARITIES; CHROMOPHORES; AGGREGATION; MEROCYANINE; CHEMISTRY; SYSTEMS AB Cyanines with long conjugation length such as heptamethines are well known to have strong intramolecular and/or intermolecular interactions (i.e., ion paring and aggregation), which can affect their structures (i.e., symmetry breaking) and optical properties remarkably. In this paper, we report a covalently linked complementary cyanine complex of cationic and anionic heptamethines forming a highly polarizable zwitterionic cyanine-cyanine salt. The effect of the modification was studied in detail on both its electronic structure and its optical properties. This novel zwitterionic salt was found to exhibit a decreased ion-pairing-induced charge localization but with an increased electronic coupling between the excited states of the cyanine cation and the anion, resulting in unusual optical properties compared to closely related noncovalent complementary cyanine salts. The dual-arm Z-scan technique was used to study their third-order NLO properties, suggesting the electronic coupling in such preorganized zwitterionic system has a weak impact on NLO properties, and both cyanines contribute to the large third-order molecular polarizabilities exceeding 4 X 10(-32) esu for potential all-optical photonic applications. C1 [Li, Zhong'an; Jang, Sei-Hum; Jen, Alex K. -Y.] Univ Washington, Dept Mat Sci & Engn, Seattle, WA 98195 USA. [Zhao, Peng; Tofighi, Salimeh; Sharma, Rajesh; Ensley, Trenton R.; Hagan, David J.; Van Stryland, Eric W.] Univ Cent Florida, CREOL, Coll Opt & Photon, Orlando, FL 32816 USA. [Ensley, Trenton R.] US Army Res Lab, Adelphi, MD 20783 USA. RP Jen, AKY (reprint author), Univ Washington, Dept Mat Sci & Engn, Seattle, WA 98195 USA.; Hagan, DJ; Van Stryland, EW (reprint author), Univ Cent Florida, CREOL, Coll Opt & Photon, Orlando, FL 32816 USA. EM hagan@creol.ucf.edu; ewvs@creol.ucf.edu; ajen@u.washington.edu FU AFOSR MURI [FA9550-10-1-0558]; Boeing-Johnson Foundation; National Science Foundation [1202471, MRI 1229563] FX This work was supported by grants from the AFOSR MURI (FA9550-10-1-0558). Alex K.-Y. Jen thanks the Boeing-Johnson Foundation for its support. E.V.S. and D.J.H. also thank the National Science Foundation under Grants ECS#1202471 and MRI 1229563. NR 34 TC 0 Z9 0 U1 4 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD JUL 21 PY 2016 VL 120 IS 28 BP 15378 EP 15384 DI 10.1021/acs.jpcc.6b03037 PG 7 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA DS2HV UT WOS:000380590600045 ER PT J AU Kirby, BT Santra, S Malinovsky, VS Brodsky, M AF Kirby, Brian T. Santra, Siddhartha Malinovsky, Vladimir S. Brodsky, Michael TI Entanglement swapping of two arbitrarily degraded entangled states SO PHYSICAL REVIEW A LA English DT Article ID POLARIZATION MODE DISPERSION; QUANTUM COMMUNICATION; BELL; TELEPORTATION; PHOTONS AB We consider entanglement swapping, a key component of quantum network operations and entanglement distribution. Pure entangled states, which are the desired input to the swapping protocol, are typically mixed by environmental interactions, causing a reduction in their degree of entanglement. Thus an understanding of entanglement swapping with partially mixed states is of importance. Here we present a general analytical solution for entanglement swapping of arbitrary two-qubit states. Our result provides a comprehensive method for analyzing entanglement swapping in quantum networks. First, we show that the concurrence of a partially mixed state is conserved when this state is swapped with a Bell state. Then, we find upper and lower bounds on the concurrence of the state resulting from entanglement swapping for various classes of input states. Finally, we determine a general relationship between the ranks of the initial states and the rank of the final state after swapping. C1 [Kirby, Brian T.; Santra, Siddhartha; Malinovsky, Vladimir S.; Brodsky, Michael] US Army, Res Lab, Adelphi, MD 20783 USA. [Santra, Siddhartha] Stanford Univ, Dept Aeronaut & Astronaut, Stanford, CA 94305 USA. RP Kirby, BT (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA. EM brian.t.kirby4.ctr@mail.mil FU Oak Ridge Associated Universities (ORAU) postdoctoral fellowship; Army Research Laboratory [W911NF-12-2-0019]; Office of the Secretary of Defense, Quantum Science and Engineering Program FX We would like to acknowledge valuable discussions with R. Brewster, J. D. Franson, G. T. Hickman, D. E. Jones, T. B. Pittman, and L. Roa. B.K. acknowledges support through an Oak Ridge Associated Universities (ORAU) postdoctoral fellowship; this research was sponsored by the Army Research Laboratory under Cooperative Agreement Number W911NF-12-2-0019. This work was supported in part by the Office of the Secretary of Defense, Quantum Science and Engineering Program. NR 34 TC 1 Z9 1 U1 4 U2 4 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9926 EI 2469-9934 J9 PHYS REV A JI Phys. Rev. A PD JUL 20 PY 2016 VL 94 IS 1 AR 012336 DI 10.1103/PhysRevA.94.012336 PG 9 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA DR7QT UT WOS:000380095500005 ER PT J AU Anglin, BS Gockel, BT Rollett, AD AF Anglin, B. S. Gockel, B. T. Rollett, A. D. TI Developing constitutive model parameters via a multi-scale approach SO INTEGRATING MATERIALS AND MANUFACTURING INNOVATION LA English DT Article DE Optimization; Constitutive law; Pearlite; Viscoplastic; Multi-scale ID MAGNESIUM ALLOY AZ31B; X-RAY-DIFFRACTION; PLASTIC-DEFORMATION; ELLIPSOIDAL INCLUSION; TEXTURE DEVELOPMENT; ELASTIC FIELD; PEARLITE; BEHAVIOR; POLYCRYSTALS; FRACTURE AB Computing the mechanical response of materials requires accurate constitutive descriptions, especially their plastic behavior. Furthermore, the ability of a model to be used as a predictive, rather than a descriptive, tool motivates the development of physically based constitutive models. This work investigates combining a homogenized viscoplastic self-consistent (VPSC) approach to reduce the development time for a high-resolution viscoplastic model based on the fast Fourier transform (FFT). An optimization scheme based on a least-squares algorithm is presented. The constitutive responses of copper, interstitial-free steel, and pearlite are investigated, and the model parameters are presented. Optimized parameters from the low-fidelity model provide close agreement (<2 MPa, similar to 1 % error) with stress-strain data at low strains (<10 %) in the high-fidelity FFT model. Simple adjustments to constitutive law parameters bring the FFT stress-strain curve in alignment with experimental data at strains greater than 10 %. A two-phase constitutive law is developed for a pearlitic steel using a single stress-strain curve, supplemented by data for the constituent phases. Sources of error and methods of using material information are discussed that lead to optimal estimates of initial parameter values. C1 [Anglin, B. S.] US Army Res Lab, Mat Response & Design Branch, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. [Gockel, B. T.] US Air Force Res Lab, Wright Patterson AFB, OH 45433 USA. [Gockel, B. T.; Rollett, A. D.] Carnegie Mellon Univ, Dept Mat Sci & Engn, 5000 Forbes Ave, Pittsburgh, PA 15213 USA. RP Anglin, BS (reprint author), US Army Res Lab, Mat Response & Design Branch, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. EM banglin@alumni.cmu.edu RI Rollett, Anthony/A-4096-2012 OI Rollett, Anthony/0000-0003-4445-2191 NR 56 TC 0 Z9 0 U1 2 U2 2 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 2193-9764 EI 2193-9772 J9 INTEGR MATER MANUF I JI Integr. Mater. Manuf. Innov. PD JUL 19 PY 2016 VL 5 AR UNSP 11 DI 10.1186/s40192-016-0053-4 PG 20 WC Materials Science, Multidisciplinary SC Materials Science GA EC3LK UT WOS:000388027400001 ER PT J AU Speake, C Pichugin, A Sahu, T Malkov, V Morrison, R Pei, Y Juompan, L Milman, N Zarling, S Anderson, C Wong-Madden, S Wendler, J Ishizuka, A MacMillen, ZW Garcia, V Kappe, SHI Krzych, U Duffy, PE AF Speake, Cate Pichugin, Alexander Sahu, Tejram Malkov, Vlad Morrison, Robert Pei, Ying Juompan, Laure Milman, Neta Zarling, Stasya Anderson, Charles Wong-Madden, Sharon Wendler, Jason Ishizuka, Andrew MacMillen, Zachary W. Garcia, Valentino Kappe, Stefan H. I. Krzych, Urszula Duffy, Patrick E. TI Identification of Novel Pre-Erythrocytic Malaria Antigen Candidates for Combination Vaccines with Circumsporozoite Protein SO PLOS ONE LA English DT Article ID PLASMODIUM-BERGHEI MALARIA; PROBE LEVEL DATA; CD8(+) T-CELLS; NAIVE ADULTS; IMMUNE-RESPONSES; IRRADIATED SPOROZOITES; PROTECTIVE IMMUNITY; FALCIPARUM-MALARIA; STERILE IMMUNITY; LIVER STAGES AB Malaria vaccine development has been hampered by the limited availability of antigens identified through conventional discovery approaches, and improvements are needed to enhance the efficacy of the leading vaccine candidate RTS, S that targets the circumsporozoite protein (CSP) of the infective sporozoite. Here we report a transcriptome-based approach to identify novel pre-erythrocytic vaccine antigens that could potentially be used in combination with CSP. We hypothesized that stage-specific upregulated genes would enrich for protective vaccine targets, and used tiling microarray to identify P. falciparum genes transcribed at higher levels during liver stage versus sporozoite or blood stages of development. We prepared DNA vaccines for 21 genes using the predicted orthologues in P. yoelii and P. berghei and tested their efficacy using different delivery methods against pre-erythrocytic malaria in rodent models. In our primary screen using P. yoelii in BALB/c mice, we found that 16 antigens significantly reduced liver stage parasite burden. In our confirmatory screen using P. berghei in C57Bl/6 mice, we confirmed 6 antigens that were protective in both models. Two antigens, when combined with CSP, provided significantly greater protection than CSP alone in both models. Based on the observations reported here, transcriptional patterns of Plasmodium genes can be useful in identifying novel pre-erythrocytic antigens that induce protective immunity alone or in combination with CSP. C1 [Speake, Cate; Malkov, Vlad; Pei, Ying; Milman, Neta; Wendler, Jason; Ishizuka, Andrew; MacMillen, Zachary W.; Garcia, Valentino; Kappe, Stefan H. I.] Seattle Biomed Res Inst, 4 Nickerson St, Seattle, WA 98109 USA. [Pichugin, Alexander; Juompan, Laure; Zarling, Stasya; Krzych, Urszula] Walter Reed Army Inst Res, Dept Cellular Immunol, Silver Spring, MD USA. [Sahu, Tejram; Morrison, Robert; Anderson, Charles; Wong-Madden, Sharon; Duffy, Patrick E.] NIAID, Lab Malaria Immunol & Vaccinol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. RP Duffy, PE (reprint author), NIAID, Lab Malaria Immunol & Vaccinol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. EM duffype@niaid.nih.gov FU PATH Malaria Vaccine Initiative; Intramural Research Program of NIAID, NIH; Military Infectious Diseases Research Program of Walter Reed Army Institute of Research FX The work was funded in part by the PATH Malaria Vaccine Initiative, by the Intramural Research Program of NIAID, NIH and the Military Infectious Diseases Research Program of Walter Reed Army Institute of Research. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 60 TC 1 Z9 1 U1 5 U2 5 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUL 19 PY 2016 VL 11 IS 7 AR e0159449 DI 10.1371/journal.pone.0159449 PG 21 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DR8TG UT WOS:000380169600053 PM 27434123 ER PT J AU Michalsen, MM King, AS Rule, RA Fuller, ME Hatzinger, PB Condee, CW Crocker, FH Indest, KJ Jung, CM Istok, JD AF Michalsen, Mandy M. King, Aaron S. Rule, Rebecca A. Fuller, Mark E. Hatzinger, Paul B. Condee, Charles W. Crocker, Fiona H. Indest, Karl J. Jung, Carina M. Istok, Jack D. TI Evaluation of Biostimulation and Bioaugmentation To Stimulate Hexahydro-1,3,5-trinitro-1,3,5,-triazine Degradation in an Aerobic Groundwater Aquifer SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID NITRAMINE EXPLOSIVE HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE; BIODEGRADATION COLUMN; MICROBIAL COMMUNITIES; RDX DEGRADATION; STRAIN DN22; RHODOCOCCUS; MINERALIZATION; MICROORGANISMS; METABOLISM; SOIL AB Hexahydro-1,3,5-trinitro-1,3,5,-triazine (RDX) is a toxic and mobile groundwater contaminant common to military sites. This study compared in situ RDX degradation rates following bioaugmentation with Gordonia sp. strain KTR9 (henceforth KTR9) to rates under biostimulation conditions in an RDX-contaminated aquifer in Umatilla, OR. Bioaugmentation was achieved by injecting site groundwater (6000 L) amended with KTR9 cells (10(8) cells mL(-1)) and low carbon substrate concentrations (<1 mM fructose) into site wells. Biostimulation (no added cells) was performed by injecting groundwater amended with low (<1 mM fructose) or high (>15 mM fructose) carbon substrate concentrations in an effort to stimulate aerobic or anaerobic microbial activity, respectively. Single-well push-pull tests were conducted to measure RDX degradation rates for each treatment. Average rate coefficients were 1.2 day(-1) for bioaugmentation and 0.7 day(-1) for high carbon biostimulation; rate coefficients for low carbon biostimulation were not significantly different from zero (p values >= 0.060). Our results suggest that bioaugmentation with KTR9 is a feasible strategy for in situ biodegradation of RDX and, at this site, is capable of achieving RDX concentration reductions comparable to those obtained by high carbon biostimulation while requiring similar to 97% less fructose. Bioaugmentation has potential to minimize substrate quantities and associated costs, as well as secondary groundwater quality impacts associated with anaerobic biostimulation processes (e.g., hydrogen sulfide, methane production) during full-scale RDX remediation. C1 [Michalsen, Mandy M.; Crocker, Fiona H.; Indest, Karl J.; Jung, Carina M.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [King, Aaron S.; Rule, Rebecca A.] US Army Corps Engineers, Seattle Dist, Seattle, WA 98134 USA. [Fuller, Mark E.; Hatzinger, Paul B.; Condee, Charles W.] CB&I Fed Serv, 17 Princess Rd, Lawrenceville, NJ 08648 USA. [Istok, Jack D.] Oregon State Univ, Sch Civil & Construct Engn, Corvallis, OR 97331 USA. RP Michalsen, MM (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. EM mandy.m.michalsen@usace.army.mil FU Environmental Security & Technology Certification Program (ESTCP) FX This research was funded by the Environmental Security & Technology Certification Program (ESTCP). The authors would like to acknowledge Christina Andaya and Randi K. Rothmel from CB&I Federal Services for providing significant laboratory and analytical support for the project, and Simon Vainberg for growing the KTR9 strain for field injection. NR 49 TC 1 Z9 1 U1 10 U2 11 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JUL 19 PY 2016 VL 50 IS 14 BP 7625 EP 7632 DI 10.1021/acs.est.6b00630 PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA DS0OD UT WOS:000380295700040 PM 27301804 ER PT J AU Yost, EE Stanek, J DeWoskin, RS Burgoon, LD AF Yost, Erin E. Stanek, John DeWoskin, Robert S. Burgoon, Lyle D. TI Estimating the Potential Toxicity of Chemicals Associated with Hydraulic Fracturing Operations Using Quantitative Structure-Activity Relationship Modeling SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID SHALE GAS DEVELOPMENT; COST-EFFECTIVE USE; MONITORING RESOURCES; WATER; GROUNDWATER; PHARMACEUTICALS; BIODEGRADATION; PROMOTE; QSARS AB The United States Environmental Protection Agency (EPA) identified 1173 chemicals associated with hydraulic fracturing fluids, flowback, or produced water, of which 1026 (87%) lack chronic oral toxicity values for human health assessments. To facilitate the ranking and prioritization of chemicals that lack toxicity values, it may be useful to employ toxicity estimates from quantitative structure activity relationship (QSAR) models. Here we describe an approach for applying the results of a QSAR model from the TOPKAT program suite, which provides estimates of the rat chronic oral lowest-observed-adverse-effect level (LOAEL). Of the 1173 chemicals, TOPKAT was able to generate LOAEL estimates for 515 (44%). To address the uncertainty associated with these estimates, we assigned qualitative confidence scores (high, medium, or low) to each TOPKAT LOAEL estimate, and found 481 to be high-confidence. For 48 both a high-confidence TOPKAT LOAEL estimate and a chronic oral reference dose from EPA's Integrated Risk Information System (IRIS) database, Spearman rank correlation identified 68% agreement between the two values (permutation p-value =1 X 10(-11)). These results provide support for the use of TOPKAT LOAEL estimates in identifying and prioritizing potentially hazardous chemicals. High-confidence TOPKAT LOAEL estimates were available for 389 of 1026 hydraulic fracturing-related chemicals that lack chronic oral RfVs and OSFs from EPA-identified sources, including a subset of chemicals that are frequently used in hydraulic fracturing fluids. C1 [Yost, Erin E.; Stanek, John; DeWoskin, Robert S.; Burgoon, Lyle D.] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA. [DeWoskin, Robert S.] EtioLogic LLC, Durham, NC 27717 USA. [Burgoon, Lyle D.] US Army Engineer Res & Dev Ctr, Environm Lab, Res Triangle Pk, NC 27709 USA. RP Burgoon, LD (reprint author), US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA.; Burgoon, LD (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, Res Triangle Pk, NC 27709 USA. EM Lyle.D.Burgoon@usace.army.mil OI Burgoon, Lyle/0000-0003-4977-5352 FU U.S. Department of Energy; EPA FX We thank Allen Davis, John Whalen, John Vandenberg, and Steve Dutton for their comments on previous drafts of this manuscript. This work was supported in part by an appointment to the Research Participation Program at the EPA National Center for Environmental Assessment, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and EPA. The views expressed in this manuscript are those of the authors and do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 35 TC 0 Z9 0 U1 20 U2 26 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JUL 19 PY 2016 VL 50 IS 14 BP 7732 EP 7742 DI 10.1021/acs.est.5b05327 PG 11 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA DS0OD UT WOS:000380295700052 PM 27172125 ER PT J AU Chahal, JS Khan, OF Cooper, CL McPartlan, JS Tsosie, JK Tilley, LD Sidik, SM Lourido, S Langer, R Bavari, S Ploegh, HL Anderson, DG AF Chahal, Jasdave S. Khan, Omar F. Cooper, Christopher L. McPartlan, Justine S. Tsosie, Jonathan K. Tilley, Lucas D. Sidik, Saima M. Lourido, Sebastian Langer, Robert Bavari, Sina Ploegh, Hidde L. Anderson, Daniel G. TI Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE nanoparticle; vaccine platform; replicon; viruses; parasites ID VENEZUELAN EQUINE ENCEPHALITIS; MESSENGER-RNA; IN-VIVO; STRANDED RNA; DNA VACCINES; CATIONIC NANOEMULSION; ANTITUMOR IMMUNITY; NONVIRAL DELIVERY; VACCINATION TRIAL; DIRECT-INJECTION AB Vaccines have had broad medical impact, but existing vaccine technologies and production methods are limited in their ability to respond rapidly to evolving and emerging pathogens, or sudden outbreaks. Here, we develop a rapid-response, fully synthetic, single-dose, adjuvant-free dendrimer nanoparticle vaccine platform wherein antigens are encoded by encapsulated mRNA replicons. To our knowledge, this system is the first capable of generating protective immunity against a broad spectrum of lethal pathogen challenges, including H1N1 influenza, Toxoplasma gondii, and Ebola virus. The vaccine can be formed with multiple antigen-expressing replicons, and is capable of eliciting both CD8(+) T-cell and antibody responses. The ability to generate viable, contaminant-free vaccines within days, to single or multiple antigens, may have broad utility for a range of diseases. C1 [Chahal, Jasdave S.; McPartlan, Justine S.; Tilley, Lucas D.; Sidik, Saima M.; Lourido, Sebastian; Ploegh, Hidde L.] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA. [Khan, Omar F.; Tsosie, Jonathan K.; Langer, Robert; Anderson, Daniel G.] MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA. [Cooper, Christopher L.; Ploegh, Hidde L.; Anderson, Daniel G.] US Army, Mol & Translat Sci, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Langer, Robert; Anderson, Daniel G.] MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02139 USA. [Langer, Robert] MIT, Dept Chem Engn, Cambridge, MA 02139 USA. [Langer, Robert; Anderson, Daniel G.] MIT, Inst Med Engn & Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA. [Langer, Robert; Anderson, Daniel G.] MIT, Harvard MIT Div Hlth Sci & Technol, Cambridge, MA 02139 USA. RP Anderson, DG (reprint author), MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.; Anderson, DG (reprint author), US Army, Mol & Translat Sci, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.; Anderson, DG (reprint author), MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02139 USA.; Anderson, DG (reprint author), MIT, Inst Med Engn & Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA.; Anderson, DG (reprint author), MIT, Harvard MIT Div Hlth Sci & Technol, Cambridge, MA 02139 USA. EM dgander@mit.edu OI Lourido, Sebastian/0000-0002-5237-1095 FU Department of Defense Office of Congressionally Directed Medical Research's Joint Warfighter Medical Research Program; MediVector, Inc. [OSP 30-1765-9901]; Ragon Institute Innovation Grant [OSP 39-1788-0101]; Defense Threat Reduction Agency/Joint Science and Technology Office programs in vaccines and pretreatments FX We thank David Langan and Jesse Steffens (US Army Medical Research Institute of Infectious Diseases) for assistance in Ebola virus vaccination/challenge studies, and Nicki Watson (W. M. Keck Microscopy Facility) for electron microcopy imagery. Electrospray ionization analysis was provided by the Koch Institute's Swanson Biotechnology Center at MIT. Funding support was provided by the Department of Defense Office of Congressionally Directed Medical Research's Joint Warfighter Medical Research Program. Partial support was provided by MediVector, Inc. Grant OSP 30-1765-9901, Ragon Institute Innovation Grant OSP 39-1788-0101, and the Defense Threat Reduction Agency/Joint Science and Technology Office programs in vaccines and pretreatments. NR 105 TC 4 Z9 4 U1 24 U2 27 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD JUL 19 PY 2016 VL 113 IS 29 BP E4133 EP E4142 DI 10.1073/pnas.1600299113 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DR9NX UT WOS:000380224500006 PM 27382155 ER PT J AU Martins, KAO Dye, JM Bavari, S AF Martins, K. A. O. Dye, J. M. Bavari, S. TI Considerations for the development of Zika virus vaccines SO VACCINE LA English DT Editorial Material ID ORIGINAL ANTIGENIC SIN; INFECTION; DENGUE C1 [Martins, K. A. O.; Dye, J. M.; Bavari, S.] US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Martins, K. A. O.] Ke Aki Technol, 5301 Buckeystown Pike,Suite 460, Frederick, MD 21704 USA. RP Martins, KAO (reprint author), Ke Aki Technol, USAMRIID, 1425 Porter St, Frederick, MD 21704 USA. EM karen.a.martins2.ctr@mail.mil NR 13 TC 6 Z9 7 U1 42 U2 50 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD JUL 19 PY 2016 VL 34 IS 33 BP 3711 EP 3712 DI 10.1016/j.vaccine.2016.06.012 PG 2 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA DS1XN UT WOS:000380418600001 PM 27318417 ER PT J AU Cartagena, CM Mountney, A Hwang, H Swiercz, A Rammelkamp, Z Boutte, AM Shear, DA Tortella, FC Schmid, KE AF Cartagena, Casandra M. Mountney, Andrea Hwang, Hye Swiercz, Adam Rammelkamp, Zoe Boutte, Angela M. Shear, Deborah A. Tortella, Frank C. Schmid, Kara E. TI Subacute Changes in Cleavage Processing of Amyloid Precursor Protein and Tau following Penetrating Traumatic Brain Injury SO PLOS ONE LA English DT Article ID ALZHEIMERS-DISEASE; CEREBROSPINAL-FLUID; BETA ACCUMULATION; CASPASE CLEAVAGE; PROGENITOR CELLS; HEAD-INJURY; PROLIFERATION; MITOCHONDRIA; AGGREGATION; FRAGMENT AB Traumatic brain injury (TBI) is an established risk factor for the development of Alzheimer's disease (AD). Here the effects of severe penetrating TBI on APP and tau cleavage processing were investigated in a rodent model of penetrating ballistic-like brain injury (PBBI). PBBI was induced by stereotactically inserting a perforated steel probe through the right frontal cortex of the anesthetized rat and rapidly inflating/deflating the probe's elastic tubing into an elliptical shaped balloon to 10% of total rat brain volume causing temporary cavitation injury. Separate animals underwent probe injury (PrI) alone without balloon inflation. Shams underwent craniectomy. Brain tissue was collected acutely (4h, 24h, 3d) and subacutely (7d) post-injury and analyzed by immunoblot for full length APP (APP-FL) and APP beta c-terminal fragments (beta CTFs), full length tau (tau-FL) and tau truncation fragments and at 7d for cytotoxic Beta amyloid (A beta) peptides A beta 40 and A beta 42 analysis. APP-FL was significantly decreased at 3d and 7d following PBBI whereas APP beta CTFs were significantly elevated by 4h post-injury and remained elevated through 7d post-injury. Effects on beta CTFs were mirrored with PrI, albeit to a lesser extent. A beta 40 and A beta 42 were significantly elevated at 7d following PBBI and PrI. Tau-FL decreased substantially 3d and 7d post-PBBI and PrI. Importantly, a 22 kDa tau fragment (tau22), similar to that found in AD, was significantly elevated by 4h and remained elevated through 7d post-injury. Thus both APP and tau cleavage was dramatically altered in the acute and subacute periods post-injury. As cleavage of these proteins has also been implicated in AD, TBI pathology shown here may set the stage for the later development of AD or other tauopathies. C1 [Cartagena, Casandra M.; Mountney, Andrea; Hwang, Hye; Swiercz, Adam; Rammelkamp, Zoe; Boutte, Angela M.; Shear, Deborah A.; Tortella, Frank C.; Schmid, Kara E.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat Branch, Silver Spring, MD 20910 USA. RP Cartagena, CM (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat Branch, Silver Spring, MD 20910 USA. EM casandra.m.cartagena@gmail.com FU U.S. Army Medical Research and Material Command, Combat Casualty Care Research Program FX This research was funded by the U.S. Army Medical Research and Material Command, Combat Casualty Care Research Program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.; We would like to thank Rebecca Pedersen and Weihong Yang for their excellent technical assistance. This research was funded by the U.S. Army Medical Research and Material Command, Combat Casualty Care Research Program. This material has been reviewed by the Walter Reed Army Institute of Research. There is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private views of the authors, and are not to be construed as official, or reflecting true views of the Department of the Army or the Department of Defense. NR 44 TC 0 Z9 1 U1 4 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUL 18 PY 2016 VL 11 IS 7 AR e0158576 DI 10.1371/journal.pone.0158576 PG 19 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DR8TD UT WOS:000380169300013 PM 27428544 ER PT J AU Vo, KT Edwards, JV Epling, CL Sinclair, E Hawkins, DS Grier, HE Janeway, KA Barnette, P Mcllvaine, E Krailo, MD Barkauskas, DA Matthay, KK Womer, RB Gorlick, RG Lessnick, SL Mackall, CL DuBois, SG AF Vo, Kieuhoa T. Edwards, Jeremy V. Epling, C. Lorrie Sinclair, Elizabeth Hawkins, Douglas S. Grier, Holcombe E. Janeway, Katherine A. Barnette, Phillip Mcllvaine, Elizabeth Krailo, Mark D. Barkauskas, Donald A. Matthay, Katherine K. Womer, Richard B. Gorlick, Richard G. Lessnick, Stephen L. Mackall, Crystal L. DuBois, Steven G. TI Impact of Two Measures of Micrometastatic Disease on Clinical Outcomes in Patients with Newly Diagnosed Ewing Sarcoma: A Report from the Children's Oncology Group SO CLINICAL CANCER RESEARCH LA English DT Article ID HEMATOPOIETIC PROGENITOR CELLS; CIRCULATING TUMOR-CELLS; BONE-MARROW; GROWTH-FACTOR; RT-PCR; RECEPTOR ANTIBODY; PERIPHERAL-BLOOD; FLOW-CYTOMETRY; PHASE-II; EXPRESSION AB Purpose: Flow cytometry and RT-PCR can detect occult Ewing sarcoma cells in the blood and bone marrow. These techniques were used to evaluate the prognostic significance of micrometastatic disease in Ewing sarcoma. Experimental Design: Newly diagnosed patients with Ewing sarcoma were enrolled on two prospective multicenter studies. In the flow cytometry cohort, patients were defined as "positive" for bone marrow micrometastatic disease if their CD99(+)/CD45(-) values were above the upper limit in 22 control patients. In the PCR cohort, RT-PCR on blood or bone marrow samples classified the patients as "positive" or "negative" for EWSR1/FLI1 translocations. The association between micrometastatic disease burden with clinical features and outcome was assessed. Coexpression of insulin-like growth factor-1 receptor (IGF-1R) on detected tumor cells was performed in a subset of flow cytometry samples. Results: The median total bone marrow CD99(+)CD45(-) percent was 0.0012%(range0%-1.10%) in the flow cytometry cohort, with 14 of 109 (12.8%) of Ewing sarcoma patients defined as "positive." In the PCR cohort, 19.6%(44/225) patients were "positive" for any EWSR1/FLI1 translocation in blood or bone marrow. There were no differences in baseline clinical features or event-free or overall survival between patients classified as "positive" versus "negative" by either method. CD99(+)CD45(-) cells had significantly higher IGF-1R expression compared with CD45(+) hematopoietic cells (mean geometric mean fluorescence intensity 982.7 vs. 190.9; P < 0.001). Conclusions: The detection of micrometastatic disease at initial diagnosis by flow cytometry or RT-PCR is not associated with outcome in newly diagnosed patients with Ewing sarcoma. Flow cytometry provides a tool to characterize occult micrometastatic tumor cells for proteins of interest. (C) 2016 AACR. C1 [Vo, Kieuhoa T.; Matthay, Katherine K.; DuBois, Steven G.] Univ Calif San Francisco, Sch Med, Dept Pediat, UCSF Benioff Childrens Hosp, San Francisco, CA 94143 USA. [Edwards, Jeremy V.] Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. [Epling, C. Lorrie; Sinclair, Elizabeth] Univ Calif San Francisco, Sch Med, UCSF Benioff Childrens Hosp, Div Expt Med,Core Immunol Lab, San Francisco, CA USA. [Hawkins, Douglas S.] Univ Washington, Fred Hutchinson Canc Res Ctr, Seattle Childrens Hosp, Div Hematol Oncol, Seattle, WA 98195 USA. [Grier, Holcombe E.; Janeway, Katherine A.] Harvard Med Sch, Dana Farber Boston Childrens Canc & Blood Disords, Boston, MA USA. [Barnette, Phillip] Univ Utah, Huntsman Canc Inst, Ctr Childrens Canc Res, Dept Pediat Hematol Oncol, Salt Lake City, UT USA. [Mcllvaine, Elizabeth; Krailo, Mark D.; Barkauskas, Donald A.] Univ Southern Calif, Keck Sch Med, Dept Preventat Med, Los Angeles, CA 90033 USA. [Womer, Richard B.] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Dept Pediat, Philadelphia, PA 19104 USA. [Gorlick, Richard G.] Albert Einstein Coll Med, Childrens Hosp Montefiore, Div Pediat Hematol Oncol, Bronx, NY 10467 USA. [Lessnick, Stephen L.] Ohio State Univ, Ctr Childhood Canc & Blood Disorders, Nationwide Childrens Hosp, Columbus, OH 43210 USA. [Lessnick, Stephen L.] Ohio State Univ, Div Hematol Oncol & BMT, Columbus, OH 43210 USA. [Mackall, Crystal L.] NCI, Pediat Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. RP DuBois, SG (reprint author), Dana Farber Canc Inst, 450 Brookline Ave,Dana 3, Boston, MA 02215 USA. EM steven_dubois@dfci.harvard.edu FU NIH [K23 CA154530, P30AI027763]; NIH Intramural Research Program; Alex's Lemonade Stand Foundation; Frank A. Campini Foundation; Hope Street Kids; Sarcoma Foundation of America; CureSearch for Children's Cancer; John M. Gilbertson Foundation; Daniel P. Sullivan Fund; WWWW (QuadW) Foundation; Children's Oncology Group grants [U10CA180886, U10CA180899, U10CA098543, U10CA098413] FX This work was supported in part by the NIH grant K23 CA154530 (to S.G. DuBois); NIH Intramural Research Program (to C.L. Mackall); NIH grant P30AI027763 to the UCSF-GIVI Center for AIDS Research (UCSF Flow Cytometry Core Laboratory); Alex's Lemonade Stand Foundation (to K.T. Vo, K.K. Matthay, and S.G. DuBois); Frank A. Campini Foundation (to K.K. Matthay and S.G. DuBois); Hope Street Kids (to S.G. DuBois); Sarcoma Foundation of America (to S.G. DuBois); CureSearch for Children's Cancer (to S.G. DuBois); John M. Gilbertson Foundation (to D.S. Hawkins); Daniel P. Sullivan Fund (to R.B. Womer); WWWW (QuadW) Foundation (to M.D. Krailo and D.A. Barkauskas); Children's Oncology Group grants (U10CA180886, U10CA180899, U10CA098543, and U10CA098413). NR 27 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1078-0432 EI 1557-3265 J9 CLIN CANCER RES JI Clin. Cancer Res. PD JUL 15 PY 2016 VL 22 IS 14 BP 3643 EP 3650 DI 10.1158/1078-0432.CCR-15-2516 PG 8 WC Oncology SC Oncology GA DS9ON UT WOS:000381113000023 PM 26861456 ER PT J AU Emmerich, T Abdullah, L Crynen, G Dretsch, M Evans, J Ait-Ghezala, G Reed, J Montague, H Chaytow, H Mathura, V Martin, J Pelot, R Ferguson, S Bishop, A Phillips, J Mullan, M Crawford, F AF Emmerich, Tanja Abdullah, Laila Crynen, Gogce Dretsch, Michael Evans, James Ait-Ghezala, Ghania Reed, Jon Montague, Hannah Chaytow, Helena Mathura, Venkatarajan Martin, Justin Pelot, Robert Ferguson, Scott Bishop, Alex Phillips, John Mullan, Michael Crawford, Fiona TI Plasma Lipidomic Profiling in a Military Population of Mild Traumatic Brain Injury and Post-Traumatic Stress Disorder with Apolipoprotein E epsilon 4-Dependent Effect SO JOURNAL OF NEUROTRAUMA LA English DT Article DE apolipoprotein E; human studies; lipidomics; phospholipids; post-traumatic stress disorder; traumatic brain injury ID NEURON-SPECIFIC ENOLASE; SEVERE HEAD-INJURY; N-3 FATTY-ACIDS; ALZHEIMERS-DISEASE; COGNITIVE DECLINE; ANIMAL-MODELS; APOE GENOTYPE; E ISOFORMS; FOLLOW-UP; SERUM AB In the military population, there is high comorbidity between mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) due to the inherent risk of psychological trauma associated with combat. These disorders present with long-term neurological dysfunction and remain difficult to diagnose due to their comorbidity and overlapping clinical presentation. Therefore, we performed cross-sectional analysis of blood samples from demographically matched soldiers (total, n = 120) with mTBI, PTSD, and mTBI+PTSD and those who were considered cognitively and psychologically normal. Soldiers were genotyped for apolipoprotein E (APOE) epsilon 4, and phospholipids (PL) were examined using liquid chromatography/mass spectrometry analysis. We observed significantly lower levels of several major PL classes in TBI, PTSD, and TBI+PTSD, compared with controls. PTSD severity analysis revealed that significant PL decreases were primarily restricted to the moderate-to-severe PTSD group. An examination of the degree of unsaturation showed that monounsaturated fatty acid-containing phosphatidylcholine (PC) and phosphatidylinositol (PI) species were lower in the TBI and TBI+PTSD groups. However, these PLs were unaltered among PTSD subjects, compared with controls. Similarly, ether PC (ePC) levels were lower in PTSD and TBI+PTSD subjects, relative to controls. Ratios of arachidonic acid (AA) to docosahexaenoic acid (DHA)-containing species were significantly decreased within PC and phosphatidylethanolamine (PE) classes. APOE epsilon 4 (+) subjects exhibited higher PL levels than their APOE epsilon 4 (-) counterparts within the same diagnostic groups. These findings suggest that PL profiles, together with APOE genotyping, could potentially aid to differentiate diagnosis of mTBI and PTSD and warrant further validation. In conclusion, PL profiling may facilitate clinical diagnosis of mTBI and PTSD currently hindered by comorbid pathology and overlapping symptomology of these two conditions. C1 [Emmerich, Tanja; Abdullah, Laila; Crynen, Gogce; Evans, James; Ait-Ghezala, Ghania; Reed, Jon; Montague, Hannah; Chaytow, Helena; Mathura, Venkatarajan; Martin, Justin; Pelot, Robert; Ferguson, Scott; Bishop, Alex; Phillips, John; Mullan, Michael; Crawford, Fiona] Roskamp Inst, 2040 Whitfield Ave, Sarasota, FL 34243 USA. [Emmerich, Tanja; Abdullah, Laila; Crynen, Gogce; Ait-Ghezala, Ghania; Mathura, Venkatarajan; Pelot, Robert; Ferguson, Scott; Mullan, Michael; Crawford, Fiona] Open Univ, Milton Keynes, Bucks, England. [Emmerich, Tanja; Abdullah, Laila; Ait-Ghezala, Ghania; Reed, Jon; Mathura, Venkatarajan; Pelot, Robert; Ferguson, Scott; Crawford, Fiona] James A Haley Vet Hosp, Tampa, FL 33612 USA. [Dretsch, Michael] Walter Reed Natl Mil Med Ctr, Natl Intrepid Ctr Excellence, Bethesda, MD USA. [Dretsch, Michael] US Army, Aeromed Res Lab, Rucker, AL USA. RP Emmerich, T (reprint author), Roskamp Inst, 2040 Whitfield Ave, Sarasota, FL 34243 USA. EM temmerich@roskampinstitute.net NR 73 TC 2 Z9 2 U1 6 U2 8 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL 15 PY 2016 VL 33 IS 14 BP 1331 EP 1348 DI 10.1089/neu.2015.4061 PG 18 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DQ5CX UT WOS:000379223100005 PM 26714394 ER PT J AU Wang, WY Darling, KA Wang, Y Shang, SL Kecskes, LJ Hui, XD Liu, ZK AF Wang, William Yi Darling, Kristopher A. Wang, Yi Shang, Shun-Li Kecskes, Laszlo J. Hui, Xi Dong Liu, Zi-Kui TI Power law scaled hardness of Mn strengthened nanocrystalline Al-Mn non-equilibrium solid solutions SO SCRIPTA MATERIALIA LA English DT Article DE Bonding charge density; Electron work function; Solid-solution hardening; Grain refinement strengthening ID HALL-PETCH RELATION; ALTERNATIVE PHYSICAL EXPLANATION; ELECTRON WORK FUNCTION; METALLIC GLASSES; ALUMINUM-ALLOY; ZR ALLOYS; TM TM; FATIGUE; DENSITY; CRYSTAL AB In this work, the effects of Mn on lattice parameter, electron work function (EWF), bonding charge density, and hardness of nanocrystalline Al-Mn non-equilibrium solid solutions are investigated. We show how the enhancement of the EWF contributes to the observed improvement of the hardness of Al-Mn solid solutions. It is understood that the physical mechanisms responsible in our model, using the EWF coupled with a power law scaled hardness, are attributed to the redistribution of electrons caused by the presence of Mn solute atoms, supporting an atomic and electronic basis for the coupling of solid solution and grain refinement strengthening mechanisms. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Wang, William Yi; Wang, Yi; Shang, Shun-Li; Liu, Zi-Kui] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. [Wang, William Yi] Northwestern Polytech Univ, Sch Mat Sci & Engn, Xian 710072, Shanxi Province, Peoples R China. [Darling, Kristopher A.; Kecskes, Laszlo J.] US Army Res Lab, Weap & Mat Res Directorate, RDRL WMM F, Aberdeen Proving Ground, MD 21005 USA. [Hui, Xi Dong] Univ Sci & Technol Beijing, State Key Lab Adv Met & Mat, Beijing 100083, Peoples R China. RP Liu, ZK (reprint author), Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA.; Kecskes, LJ (reprint author), US Army Res Lab, Weap & Mat Res Directorate, RDRL WMM F, Aberdeen Proving Ground, MD 21005 USA. EM laszloj.kecskes.civ@mail.mil; dr.Liu@psu.edu RI Wang, William Yi/F-8212-2011; Shang, Shun-Li/A-6564-2009; Wang, Yi/D-1032-2013; Liu, Zi-Kui/A-8196-2009 OI Wang, William Yi/0000-0002-8814-525X; Shang, Shun-Li/0000-0002-6524-8897; Liu, Zi-Kui/0000-0003-3346-3696 FU United States National Science Foundation (NSF) [DMR-1006557]; U.S. Army Research Laboratory [W911NF-08-2-0084]; National Natural Science Foundation of China [50871013, 51271018]; Project Based Personnel Exchange Program; American Academic Exchange Service; China Scholarship Council [[2008]3072]; Materials Simulation Center; Institute for CyberScience; NSF [OCI-0821527]; XSEDE clusters - NSF [ACI-1053575] FX We greatly acknowledge the financial support from the United States National Science Foundation (NSF) (grant DMR-1006557), the U.S. Army Research Laboratory (project no. W911NF-08-2-0084), and the National Natural Science Foundation of China (grants 50871013 and 51271018). W.Y. Wang acknowledges the support from the Project Based Personnel Exchange Program with the American Academic Exchange Service and the China Scholarship Council ([2008]3072). First-principles calculations were carried out on the LION clusters at the Pennsylvania State University supported by the Materials Simulation Center and the Institute for CyberScience. Calculations were also carried out on the CyberStar cluster funded by NSF through grant OCI-0821527 and the XSEDE clusters supported by NSF through grant ACI-1053575. NR 59 TC 0 Z9 0 U1 12 U2 35 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6462 J9 SCRIPTA MATER JI Scr. Mater. PD JUL 15 PY 2016 VL 120 BP 31 EP 36 DI 10.1016/j.scriptamat.2016.04.003 PG 6 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA DN1DT UT WOS:000376807200008 ER PT J AU Brewer, SJ Deng, CZ Callaway, CP Paul, MK Fisher, KJ Guerrier, JE Rudy, RQ Polcawich, RG Jones, JL Glaser, ER Cress, CD Bassiri-Gharb, N AF Brewer, Steven J. Deng, Carmen Z. Callaway, Connor P. Paul, McKinley K. Fisher, Kenzie J. Guerrier, Jonathon E. Rudy, Ryan Q. Polcawich, Ronald G. Jones, Jacob L. Glaser, Evan R. Cress, Cory D. Bassiri-Gharb, Nazanin TI Effect of top electrode material on radiation-induced degradation of ferroelectric thin film structures SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID GAMMA-RAY IRRADIATION; AU/PBZR0.52TI0.48O3/YBA2CU3O7-DELTA CAPACITORS; RETENTION CHARACTERISTICS; POLARIZATION RETENTION; ELECTRICAL-PROPERTIES; TI)O-3 CAPACITORS; FATIGUE; CERAMICS; OXIDE; MECHANISMS AB The effects of gamma irradiation on the dielectric and piezoelectric responses of Pb[Zr(0.5)2Ti(0.48)]O-3 (PZT) thin film stacks were investigated for structures with conductive oxide (IrO2) and metallic (Pt) top electrodes. The samples showed, generally, degradation of various key dielectric, ferroelectric, and electromechanical responses when exposed to 2.5 Mrad (Si) Co-60 gamma radiation. However, the low-field, relative dielectric permittivity, epsilon(r), remained largely unaffected by irradiation in samples with both types of electrodes. Samples with Pt top electrodes showed substantial degradation of the remanent polarization and overall piezoelectric response, as well as pinching of the polarization hysteresis curves and creation of multiple peaks in the permittivity-electric field curves post irradiation. The samples with oxide electrodes, however, were largely impervious to the same radiation dose, with less than 5% change in any of the functional characteristics. The results suggest a radiation-induced change in the defect population or defect energy in PZT with metallic top electrodes, which substantially affects motion of internal interfaces such as domain walls. Additionally, the differences observed for stacks with different electrode materials implicate the ferroelectric-electrode interface as either the predominant source of radiation-induced effects (Pt electrodes) or the site of healing for radiation-induced defects (IrO2 electrodes). Published by AIP Publishing. C1 [Brewer, Steven J.; Paul, McKinley K.; Fisher, Kenzie J.; Bassiri-Gharb, Nazanin] Georgia Inst Technol, GW Woodruff Sch Mech Engn, Atlanta, GA 30332 USA. [Brewer, Steven J.; Deng, Carmen Z.; Callaway, Connor P.; Bassiri-Gharb, Nazanin] Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA. [Paul, McKinley K.] Woodward Acad, College Pk, MD 30337 USA. [Fisher, Kenzie J.] Riverwood Int Charter Sch, Atlanta, GA 30328 USA. [Guerrier, Jonathon E.; Jones, Jacob L.] North Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Rudy, Ryan Q.; Polcawich, Ronald G.] Army Res Lab, Adelphi, MD 20783 USA. [Glaser, Evan R.; Cress, Cory D.] Naval Res Lab, Washington, DC 20375 USA. RP Brewer, SJ (reprint author), Georgia Inst Technol, GW Woodruff Sch Mech Engn, Atlanta, GA 30332 USA.; Brewer, SJ (reprint author), Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA. OI Callaway, Connor/0000-0002-0848-1000; Cress, Cory/0000-0001-7563-6693 FU Defense Threat Reduction Agency [HDTRA1-15-1-0035] FX This work was supported by the Defense Threat Reduction Agency, Basic Research Award No. #HDTRA1-15-1-0035, to Georgia Institute of Technology. The contents do not necessarily reflect the position or the policy of the federal government, and no official endorsement should be inferred. The authors acknowledge the contributions of Joel Martin and Brian Power of the Army Research Laboratory and Steven Isaacson of General Technical Services for their roles in the fabrication of the PZT thin films and MEMS devices. They also acknowledge the use of the Analytical Instrumentation Facility (AIF) at North Carolina State University, which is supported by the State of North Carolina and the National Science Foundation. NR 59 TC 1 Z9 1 U1 10 U2 10 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD JUL 14 PY 2016 VL 120 IS 2 AR 024101 DI 10.1063/1.4955424 PG 9 WC Physics, Applied SC Physics GA DT0CW UT WOS:000381151200005 ER PT J AU Golt, MC Strawhecker, KE Bratcher, MS Shanholtz, ER AF Golt, M. C. Strawhecker, K. E. Bratcher, M. S. Shanholtz, E. R. TI Polycrystalline silicon carbide dopant profiles obtained through a scanning nano-Schottky contact SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID ATOMIC-FORCE MICROSCOPY; THERMIONIC-FIELD EMISSION; BARRIER HEIGHT; GRAIN-BOUNDARIES; CERAMICS; DEPENDENCE; INTERFACES; TRANSPORT; SIC/SIO2; DIODES AB The unique thermo-electro-mechanical properties of polycrystalline silicon carbide (poly-SiC) make it a desirable candidate for structural and electronic materials for operation in extreme environments. Necessitated by the need to understand how processing additives influence poly-SiC structure and electrical properties, the distribution of lattice defects and impurities across a specimen of hot-pressed 6H poly-SiC processed with p-type additives was visualized with high spatial resolution using a conductive atomic force microscopy approach in which a contact forming a nano-Schottky interface is scanned across the sample. The results reveal very intricate structures within poly-SiC, with each grain having a complex core-rim structure. This complexity results from the influence the additives have on the evolution of the microstructure during processing. It was found that the highest conductivities localized at rims as well as at the interface between the rim and the core. The conductivity of the cores is less than the conductivity of the rims due to a lower concentration of dopant. Analysis of the observed conductivities and current-voltage curves is presented in the context of nano-Schottky contact regimes where the conventional understanding of charge transport to diode operation is no longer valid. C1 [Golt, M. C.; Strawhecker, K. E.; Bratcher, M. S.] US Army Res Lab, WMRD, Aberdeen Proving Ground, MD 21005 USA. [Shanholtz, E. R.] ORISE, Belcamp, MD 21017 USA. RP Golt, MC (reprint author), US Army Res Lab, WMRD, Aberdeen Proving Ground, MD 21005 USA. FU U.S. Department of Energy; U.S. Army Research Laboratory FX The authors would like to thank Dr. Thomas Parker for performing XPS analysis of the native oxide thickness and Dr. Kristopher Behler for performing the Raman analysis of the polytype composition. This project was supported in part by an appointment to the Internship/Research Participation Program for the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education (ORISE) through an agreement between the U.S. Department of Energy and the U.S. Army Research Laboratory. NR 41 TC 0 Z9 0 U1 3 U2 3 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD JUL 14 PY 2016 VL 120 IS 2 AR 024302 DI 10.1063/1.4957177 PG 10 WC Physics, Applied SC Physics GA DT0CW UT WOS:000381151200007 ER PT J AU NaraseGowda, S Brown, CM Tyagi, M Jenkins, T Dobbins, TA AF NaraseGowda, Shathabish Brown, Craig M. Tyagi, Madhusudan Jenkins, Timothy Dobbins, Tabbetha A. TI Quasi-Elastic Neutron Scattering Studies of Hydrogen Dynamics for Nanoconfined NaAIH(4) SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID ROTATIONAL-DYNAMICS; MOLECULAR-HYDROGEN; AMMONIA BORANE; DIFFUSION; SODIUM; CARBON; H-2; THERMODYNAMICS; REORIENTATIONS; SPECTROMETER AB The hydrogen dynamics of nanoconfined sodium Alanate (NaAlH4) has been studied using quasi-elastic neutron scattering (QENS). Results indicate thermodynamic destabilization is responsible for reduced desorption temperatures of NaAlH4 upon confinement within the nanopores of a metal organic framework (MOP). The quasi-elastic broadening in the nano-NaAlH4 indicates that there are two dynamic states of hydrogen, which can be tracked by fitting the QENS signal to Lorentzian functions. The fastest hydrogen dynamics show some limited amount and range of long-range diffusion (i.e., not spatially confined motion) as indicated by a weakly varying Q-dependent fwhm on the broad Lorentzian quasi-elastic broadening data. These data trend toward zero at Q = 0 A(-1). Slower hydrogen dynamics, described by a narrow Lorentzian function, are present in the nanoconfined sample and can be attributed to reorientation and localized motion of H around AlHx tetrahedra. Both the as-purchased NaAlH4 (hereafter called "bulk" or "micro" NaAlH4) and the nanoconfined NaAlH4 data were fitted to reorientation models which yielded corresponding percent mobile hydrogen and jump lengths. The jump lengths calculated from the nano-NaAlH4 were approximate to 2.5 angstrom and in conformity with those jump lengths determined for bulk NaAlH4 of approximate to 2.3 angstrom. As much as 18% of the hydrogen atoms were estimated to be mobile in the nano-NaAlH4 sample even at relatively low temperatures of 350 K. In contrast, bulk NaAlH4 shows less than 7% mobile H atoms even at higher temperatures of approximate to 450 K. The hydrogen motion in the nanoconfined samples are fitted to a "high temperature (HT)" reorientation model in which a motion occurs by "tumbling" reorientation of AlHx tetrahedra. The model assumes 3 of the 4 H atoms in the AlH4 tetrahedra to be continuously exchanging their coplanar positions plus taking turns to exchange position with the fourth axial H atom. The microscale sample was fitted to a convoluted 2-site/3-site model, which can be viewed as three-dimensional jumps requiring the reorientation of the AlH4 tetrahedra. The activation energy is 3.1 meV (at 125-320 K) and the attempt frequency (or energy) is 4.7 meV for this motion. C1 [NaraseGowda, Shathabish] Louisiana Tech Univ, Inst Micromfg, Ruston, LA 71272 USA. [Brown, Craig M.] Univ Delaware, Dept Chem & Biomol Engn, Newark, DE 19716 USA. [Brown, Craig M.; Tyagi, Madhusudan] NIST, Ctr Neutron Res, Gaithersburg, MD 20899 USA. [Tyagi, Madhusudan] Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA. [Jenkins, Timothy] Army Res Lab, Aberdeen, MD 21005 USA. [Dobbins, Tabbetha A.] Rowan Univ, Dept Phys & Astron, Glassboro, NJ 08096 USA. [NaraseGowda, Shathabish] Intel Corp, 2501 NW 229th Ave, Hillsboro, OR 97124 USA. RP Dobbins, TA (reprint author), Rowan Univ, Dept Phys & Astron, Glassboro, NJ 08096 USA. EM dobbins@rowan.edu RI Brown, Craig/B-5430-2009 OI Brown, Craig/0000-0002-9637-9355 FU NSF [DMR1231153]; U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-98CH10886]; National Science Foundation [DMR-1508249]; LA-SiGMA [EPS-1003897] FX General support came from the NSF (Grant No. DMR1231153). Our use of the National Synchrotron Light Source (NSLS), Brookhaven National Laboratory, was supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No. DE-AC02-98CH10886. Diffraction data were collected at beamline X14A of the NSLS. This work utilized the Center For High Resolution Neutron Scattering (CHRNS) facilities, which are supported in part by the National Science Foundation under Agreement No. DMR-1508249. S.N.A. acknowledges LA-SiGMA (Grant No. EPS-1003897) for graduate assistantship in the last one year of study to completion of his dissertation. Identification of a commercial product does not imply recommendation or endorsement by the NIST, nor does it imply that the product is necessarily the best for the stated purpose. NR 50 TC 0 Z9 0 U1 2 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD JUL 14 PY 2016 VL 120 IS 27 BP 14863 EP 14873 DI 10.1021/acs.jpcc.6b02431 PG 11 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA DR6CT UT WOS:000379990400045 ER PT J AU McPhillie, M Zhou, Y El Bissati, K Dubey, J Lorenzi, H Capper, M Lukens, AK Hickman, M Muench, S Verma, SK Weber, CR Wheeler, K Gordon, J Sanders, J Moulton, H Wang, K Kim, TK He, YQ Santos, T Woods, S Lee, P Donkin, D Kim, E Fraczek, L Lykins, J Esaa, F Alibana-Clouser, F Dovgin, S Weiss, L Brasseur, G Wirth, D Kent, M Hood, L Meunieur, B Roberts, CW Hasnain, SS Antonyuk, SV Fishwick, C McLeod, R AF McPhillie, Martin Zhou, Ying El Bissati, Kamal Dubey, Jitender Lorenzi, Hernan Capper, Michael Lukens, Amanda K. Hickman, Mark Muench, Stephen Verma, Shiv Kumar Weber, Christopher R. Wheeler, Kelsey Gordon, James Sanders, Justin Moulton, Hong Wang, Kai Kim, Taek-Kyun He, Yuqing Santos, Tatiana Woods, Stuart Lee, Patty Donkin, David Kim, Eric Fraczek, Laura Lykins, Joseph Esaa, Farida Alibana-Clouser, Fatima Dovgin, Sarah Weiss, Louis Brasseur, Gael Wirth, Dyann Kent, Michael Hood, Leroy Meunieur, Brigitte Roberts, Craig W. Hasnain, S. Samar Antonyuk, Svetlana V. Fishwick, Colin McLeod, Rima TI New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections SO SCIENTIFIC REPORTS LA English DT Article ID ACQUIRED-IMMUNODEFICIENCY-SYNDROME; CYTOCHROME BC(1) COMPLEX; TOXOPLASMA-GONDII; PLASMODIUM-FALCIPARUM; IN-VITRO; CONGENITAL TOXOPLASMOSIS; ELECTRON-TRANSPORT; NERVOUS-SYSTEM; REDUCTION SITE; ATOVAQUONE AB Toxoplasma gondii, the most common parasitic infection of human brain and eye, persists across lifetimes, can progressively damage sight, and is currently incurable. New, curative medicines are needed urgently. Herein, we develop novel models to facilitate drug development: EGS strain T. gondii forms cysts in vitro that induce oocysts in cats, the gold standard criterion for cysts. These cysts highly express cytochrome b. Using these models, we envisioned, and then created, novel 4-(1H)-quinolone scaffolds that target the cytochrome bc(1) complex Q(i) site, of which, a substituted 5,6,7,8-tetrahydroquinolin-4-one inhibits active infection (IC50, 30 nM) and cysts (IC50, 4 mu M) in vitro, and in vivo (25 mg/kg), and drug resistant Plasmodium falciparum (IC50, < 30 nM), with clinically relevant synergy. Mutant yeast and co-crystallographic studies demonstrate binding to the bc(1) complex Q(i) site. Our results have direct impact on improving outcomes for those with toxoplasmosis, malaria, and similar to 2 billion persons chronically infected with encysted bradyzoites. C1 [McPhillie, Martin; Muench, Stephen; Gordon, James; Fishwick, Colin] Univ Leeds, Leeds, W Yorkshire, England. [Zhou, Ying; El Bissati, Kamal; Weber, Christopher R.; Wheeler, Kelsey; Fraczek, Laura; Lykins, Joseph; Esaa, Farida; Alibana-Clouser, Fatima; Dovgin, Sarah; McLeod, Rima] Univ Chicago, Chicago, IL 60637 USA. [Dubey, Jitender; Verma, Shiv Kumar] USDA, Beltsville, MD 20705 USA. [Lorenzi, Hernan] J Craig Venter Inst, Rockville, MD USA. [Capper, Michael; Hasnain, S. Samar; Antonyuk, Svetlana V.] Univ Liverpool, Liverpool, Merseyside, England. [Lukens, Amanda K.; Wirth, Dyann] Harvard Univ, Sch Publ Hlth, 665 Huntington Ave, Boston, MA 02115 USA. [Lukens, Amanda K.; Wirth, Dyann] Broad Inst, Boston, MA USA. [Hickman, Mark; Lee, Patty; Donkin, David; Kim, Eric] Walter Reed Army Inst Res, Silver Spring, MD USA. [Sanders, Justin; Moulton, Hong; Kent, Michael] Oregon State Univ, Corvallis, OR 97331 USA. [Wang, Kai; Kim, Taek-Kyun; He, Yuqing; Hood, Leroy] Inst Syst Biol, Seattle, WA USA. [Santos, Tatiana; Weiss, Louis] Albert Einstein Coll Med, Bronx, NY 10467 USA. [Woods, Stuart; Roberts, Craig W.] Strathclyde Univ, Glasgow, Lanark, Scotland. [Brasseur, Gael] CNRS, Marseilles, France. [Meunieur, Brigitte] Inst Integrat Biol Cell 12BC, Gif Sur Yvette, France. RP Fishwick, C (reprint author), Univ Leeds, Leeds, W Yorkshire, England.; McLeod, R (reprint author), Univ Chicago, Chicago, IL 60637 USA.; Antonyuk, SV (reprint author), Univ Liverpool, Liverpool, Merseyside, England. EM antonyuk@liverpool.ac.uk; c.w.g.fishwick@leeds.ac.uk; rmcleod@uchicago.edu OI Roberts, Craig/0000-0002-0653-835X FU NIH NIAID DMID [AI U01AI082180]; Mann Cornwell Family; Engel family and "Taking out Toxo"; Rooney family; Morel family; Wellcome Trust; BBSRC; National Institute of Allergy and Infectious Diseases of the National Institutes of Health [HHSN272200900007C, U19AI110819]; DTRA; DOD [HDTRA1-13-C-0055, W911NF-09-D0001, W911SR-07-C0101] FX This work was supported by Grant number AI U01AI082180 from NIH NIAID DMID and by the Mann Cornwell Family, the Engel family and "Taking out Toxo", the Rooney and the Morel families. University of Liverpool team was supported via Wellcome Trust and BBSRC and would like to acknowledge on-going collaboration with Professor Paul O'Neil (Chemistry, U of Liverpool) and Prof Giancarlo Biangini (LSTM) on a related project on Plasmodium falciparum. We acknowledge the support of crystallographic facilities at DIAMOND (UK). Research reported in this publication also was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under Contract Number HHSN272200900007C and Award Number U19AI110819. The team at the Institute for Systems Biology is partially supported by research contracts from DTRA and DOD (HDTRA1-13-C-0055, W911NF-09-D0001 and W911SR-07-C0101). We acknowledge Openeye Inc for the generous provision of an Academic software license. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. We thank Ian Begeman for his assistance in the preparation of this manuscript. We thank Eleonor Lago MD PhD for providing the cost analysis data for Brazil. NR 65 TC 0 Z9 0 U1 4 U2 4 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD JUL 14 PY 2016 VL 6 AR 29179 DI 10.1038/srep29179 PG 23 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DQ9YS UT WOS:000379565800001 PM 27412848 ER PT J AU Zhang, W Liu, Y Jackson, AC Savage, AM Ertem, SP Tsai, TH Seifert, S Beyer, FL Liberatore, MW Herring, AM Coughlin, EB AF Zhang, Wenxu Liu, Ye Jackson, Aaron C. Savage, Alice M. Ertem, S. Piril Tsai, Tsung-Han Seifert, Soenke Beyer, Frederick L. Liberatore, Matthew W. Herring, Andrew M. Coughlin, E. Bryan TI Achieving Continuous Anion Transport Domains Using Block Copolymers Containing Phosphonium Cations SO MACROMOLECULES LA English DT Article ID FUEL-CELL APPLICATIONS; POLYMER ELECTROLYTE MEMBRANES; CHAIN TRANSFER POLYMERIZATION; HYDROXIDE EXCHANGE MEMBRANES; ABA TRIBLOCK COPOLYMERS; PHASE-BEHAVIOR; BUTYL ACRYLATE; IONIC LIQUIDS; FUNCTIONALIZED POLYETHYLENE; RADICAL POLYMERIZATION AB Triblock and diblock copolymers based on isoprene (Ip) and chloromethylstyrene (CMS) were synthesized by sequential polymerization using reversible addition-fragmentation chain transfer radical polymerization (RAFT). The block copolymers were quaternized with tris(2,4,6-trimethoxyphenyl)phosphine (Ar3P) to prepare soluble ionomers. The ionomers were cast from chloroform to form anion exchange membranes (AEMs) with highly ordered morphologies. At low volume fractions of ionic blocks, the ionomers formed lamellar morphologies, while at moderate volume fractions (>= 30% for triblock and >= 22% for diblock copolymers) hexagonal phases with an ionic matrix were observed. Ion conductivities were higher through the hexagonal phase matrix than in the lamellar phases. Promising chloride conductivities (20 mS/cm) were achieved at elevated temperatures and humidified conditions. C1 [Zhang, Wenxu; Ertem, S. Piril; Tsai, Tsung-Han; Coughlin, E. Bryan] Univ Massachusetts, Dept Polymer Sci & Engn, 120 Governors Dr, Amherst, MA 01003 USA. [Liu, Ye; Herring, Andrew M.] Colorado Sch Mines, Dept Chem & Biol Engn, Golden, CO 80401 USA. [Jackson, Aaron C.; Savage, Alice M.; Beyer, Frederick L.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Seifert, Soenke] Argonne Natl Lab, Xray Sci Div, 9700 S Cass Ave, Argonne, IL 60439 USA. [Liberatore, Matthew W.] Univ Toledo, Dept Chem & Environm Engn, 2801 W Bancroft St, Toledo, OH 43606 USA. RP Coughlin, EB (reprint author), Univ Massachusetts, Dept Polymer Sci & Engn, 120 Governors Dr, Amherst, MA 01003 USA. EM Coughlin@mail.pse.umass.edu RI Liberatore, Matthew/B-6828-2008; OI Herring, Andrew/0000-0001-7318-5999 FU Army Research Office through MURI award [W911NF-10-1-0520]; NSF; DOE Office of Science by Argonne National Laboratory [DE-AC02-06CH11357]; Postgraduate Research Participation Program at the US Army Research Laboratory [ORISE 1120-1120-99] FX The authors gratefully acknowledge financial support from the Army Research Office through a MURI award, W911NF-10-1-0520, and the central analytical facilities used in these investigations are supported by the NSF-Sponsored MRSEC at UMass Amherst. This research used resources of the Advanced Photon Source, a U.S. Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under Contract DE-AC02-06CH11357. A.C.J. and A.M.S. were supported by the Postgraduate Research Participation Program at the US Army Research Laboratory, administered by the Oak Ridge Institute of Science and Education through an interagency agreement between the US Department of Energy and Army Research Laboratory (Contract ORISE 1120-1120-99). NR 101 TC 1 Z9 1 U1 4 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0024-9297 EI 1520-5835 J9 MACROMOLECULES JI Macromolecules PD JUL 12 PY 2016 VL 49 IS 13 BP 4714 EP 4722 DI 10.1021/acs.macromol.6b00653 PG 9 WC Polymer Science SC Polymer Science GA DR1ZI UT WOS:000379704000004 ER PT J AU Hellmuth, J Fletcher, JLK Valcour, V Kroon, E Ananworanich, J Intasan, J Lerdlum, S Narvid, J Pothisri, M Allen, I Krebs, SJ Slike, B Prueksakaew, P Jagodzinski, LL Puttamaswin, S Phanuphak, N Spudich, S AF Hellmuth, Joanna Fletcher, James L. K. Valcour, Victor Kroon, Eugene Ananworanich, Jintanat Intasan, Jintana Lerdlum, Sukalaya Narvid, Jared Pothisri, Mantana Allen, Isabel Krebs, Shelly J. Slike, Bonnie Prueksakaew, Peeriya Jagodzinski, Linda L. Puttamaswin, Suwanna Phanuphak, Nittaya Spudich, Serena CA SEARCH 010 RV254 Study Grp TI Neurologic signs and symptoms frequently manifest in acute HIV infection SO NEUROLOGY LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; CENTRAL-NERVOUS-SYSTEM; BILATERAL BELL PALSY; ANTIRETROVIRAL THERAPY; SEROCONVERSION; ENCEPHALOMYELITIS; PARKINSONISM; PERFORMANCE; IMPAIRMENT AB Objective: To determine the incidence, timing, and severity of neurologic findings in acute HIV infection (pre-antibody seroconversion), as well as persistence with combination antiretroviral therapy (cART). Methods: Participants identified with acute HIV were enrolled, underwent structured neurologic evaluations, immediately initiated cART, and were followed with neurologic evaluations at 4 and 12 weeks. Concurrent brain MRIs and both viral and inflammatory markers in plasma and CSF were obtained. Results: Median estimated HIV infection duration was 19 days (range 3-56) at study entry for the 139 participants evaluated. Seventy-three participants (53%) experienced one or more neurologic findings in the 12 weeks after diagnosis, with one developing a fulminant neurologic manifestation (Guillain-Barre syndrome). A total of 245 neurologic findings were noted, reflecting cognitive symptoms (33%), motor findings (34%), and neuropathy (11%). Nearly half of the neurologic findings (n = 121, 49%) occurred at diagnosis, prior to cART initiation, and most of these (n = 110, 90%) remitted concurrent with 1 month on treatment. Only 9% of neurologic findings (n = 22) persisted at 24 weeks on cART. Nearly all neurologic findings (n = 236, 96%) were categorized as mild in severity. No structural neuroimaging abnormalities were observed. Participants with neurologic findings had a higher mean plasma log(10) HIV RNA at diagnosis compared to those without neurologic findings (5.9 vs 5.4; p = 0.006). Conclusions: Acute HIV infection is commonly associated with mild neurologic findings that largely remit while on treatment, and may be mediated by direct viral factors. Severe neurologic manifestations are infrequent in treated acute HIV. C1 [Hellmuth, Joanna; Valcour, Victor] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA. [Narvid, Jared] Univ Calif San Francisco, Dept Radiol, San Francisco, CA USA. [Allen, Isabel] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA. [Fletcher, James L. K.; Kroon, Eugene; Intasan, Jintana; Prueksakaew, Peeriya; Puttamaswin, Suwanna; Phanuphak, Nittaya] Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, Thailand. [Ananworanich, Jintanat; Krebs, Shelly J.; Slike, Bonnie; Jagodzinski, Linda L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Ananworanich, Jintanat; Krebs, Shelly J.; Slike, Bonnie] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Lerdlum, Sukalaya; Pothisri, Mantana] Chulalongkorn Univ, Dept Radiol, Bangkok, Thailand. [Spudich, Serena] Yale Univ, Dept Neurol, New Haven, CT USA. RP Hellmuth, J (reprint author), Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA. EM joanna.hellmuth@ucsf.edu FU NIH/NIMH [R01MH095613, R01NS061696, R21MH086341]; US Military HIV Research Program; National Institutes of Mental Health FX Supported by NIH/NIMH grants R01MH095613, R01NS061696, and R21MH086341, as well as the US Military HIV Research Program, with added support from the National Institutes of Mental Health. The following organizations provided antiretroviral therapy: tenofovir, lamivudine, efavirenz from the Thai Government Pharmaceutical Organization; emtricitabine/tenofovir (Truvada) and emtricitabine/tenofovir/efavirenz (Sustiva) from Gilead (Foster City, CA); efavirenz (Sustiva) and raltegravir (Isentress) from Merck (San Francisco, CA); and maraviroc (Selzentry) from ViiV Healthcare (Middlesex, UK). The funders had no role in the design of this study, data collection or analysis, the preparation of the manuscript, or decision to publish. NR 30 TC 3 Z9 3 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0028-3878 EI 1526-632X J9 NEUROLOGY JI Neurology PD JUL 12 PY 2016 VL 87 IS 2 BP 148 EP 154 DI 10.1212/WNL.0000000000002837 PG 7 WC Clinical Neurology SC Neurosciences & Neurology GA DT4SI UT WOS:000381470700033 PM 27287217 ER PT J AU Schwacha, MG Rani, M Nicholson, SE Lewis, AM Holloway, TL Sordo, S Cap, AP AF Schwacha, Martin G. Rani, Meenakshi Nicholson, Susannah E. Lewis, Aaron M. Holloway, Travis L. Sordo, Salvador Cap, Andrew P. TI Dermal gamma delta T-Cells Can Be Activated by Mitochondrial Damage-Associated Molecular Patterns SO PLOS ONE LA English DT Article ID INFLAMMATORY RESPONSE; ANTIGEN RECEPTORS; THERMAL-INJURY; IMMUNE-SYSTEM; UP-REGULATION; BURN INJURY; WOUND SITE; LYMPHOCYTES; MECHANISMS; NECROSIS AB Background Gamma delta T-cells have been shown to be important to the early immunoinflammatory response to injury, independent of infection. This unique T-cell population acts to regulate cell trafficking and the release of cytokines and growth factors. We propose this sterile inflammatory response is in part associated with damage associated molecular patterns (DAMPs) generated by major injury, such as burn, and mediated via toll-like receptors (TLRs). It is unknown whether DAMPs can activate resident gamma delta T-cells that reside in skin. Methods Gamma delta T-cells were isolated from the skin of male C57BL/6 mice by enzymatic digestion. Mitochondrial DAMPs (MTDs) were generated from mitochondria isolated from mouse livers by sonication and centrifugation. Dermal gamma delta T-cells were incubated with MTDs (0500 mu g/ml) for 24 hr and cells and supernatants were collected for analysis. Results MTDs activated dermal gamma delta T-cells, as evidenced by increased TLR2 and TLR4 expression following in vitro exposure. MTDs also induced the production of inflammatory cytokines (IL-1 beta, IL-6), and growth factors (PDGF and VEGF) by gamma delta T-cells. Conclusions These findings herein support the concept that MTDs released after tissue/cellular injury are capable of activating dermal gamma delta T-cells. We propose that the activation of this unique T-cell population is central in the initiation of sterile inflammation and also contributes to the subsequent healing processes. C1 [Schwacha, Martin G.; Rani, Meenakshi; Nicholson, Susannah E.; Lewis, Aaron M.; Holloway, Travis L.; Sordo, Salvador; Cap, Andrew P.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA. [Schwacha, Martin G.; Cap, Andrew P.] US Army, Inst Surg Res, Blood Res, Ft Sam Houston, TX USA. RP Schwacha, MG (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA.; Schwacha, MG (reprint author), US Army, Inst Surg Res, Blood Res, Ft Sam Houston, TX USA. EM Schwacha@uthscsa.edu FU National Institutes of Health [GM079122, 5T32GM079085]; UTHSCSA NIH [KL2 TR001118]; UTHSCSA Department of Surgery NIH T32 Training Grant [5T32GM079085] FX This work was supported by the National Institutes of Health: GM079122, 5T32GM079085. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.; These finding were presented in part at the 38th Annual Conference on Shock in Denver CO. This study was supported by NIH grant GM079122, SEN was supported in part by the UTHSCSA NIH grant KL2 TR001118, and TLH was supported under the UTHSCSA Department of Surgery NIH T32 Training Grant (5T32GM079085). The opinions or assertions contained herein are the private views of the author and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. The authors declare that they have no competing interests. We thank Qiong Zhang for her excellent technical assistance in the laboratory and LuAnn Kirk for editorial assistance. NR 45 TC 0 Z9 0 U1 3 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUL 12 PY 2016 VL 11 IS 7 AR e0158993 DI 10.1371/journal.pone.0158993 PG 15 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DQ9CO UT WOS:000379508200026 PM 27403524 ER PT J AU Kolar, E Catthoor, RPR Kriel, FH Sedev, R Middlemas, S Klier, E Hatch, G Priest, C AF Kolar, Elisabeth Catthoor, Rik P. R. Kriel, Frederik H. Sedev, Rossen Middlemas, Scott Klier, Eric Hatch, Gareth Priest, Craig TI Microfluidic solvent extraction of rare earth elements from a mixed oxide concentrate leach solution using Cyanex (R) 572 SO CHEMICAL ENGINEERING SCIENCE LA English DT Article DE Rare earth elements; Solvent extraction; Microfluidics; Leachate; Extraction rate; Cyanex (R) 572 ID DROP SIZE DISTRIBUTIONS; GLASS CHIP; METAL-IONS; DEVICES; SYSTEM; MICROREACTOR; MICROCHANNEL; INTEGRATION; PLATINUM AB Solvent extraction of rare earth elements (REEs) involves hundreds of individual extraction and phase separation cycles, fine adjustment of solution conditions, and individual stage and overall process times that are long. Therefore, we investigated microfluidic solvent extraction (microSX) of REEs from a leached mixed rare earth oxide (REO) mineral concentrate using a phosphorus-based cationic exchange extractant (Cyanex (R) 572). A Y-Y microchip was used, in which the aqueous and organic phases were contacted for up to 15 s with sub-second resolution. The extraction rate and selectivity for heavy REEs was determined for the prepared leach solution. Good selectivity for heavy REEs was observed using the microchip for leach solutions adjusted to pH 0.7. Extraction rates on the microchip were typically double that observed in conventional (bulk) solvent extractions, except for Lu and Yb, which were three-times faster. The faster extraction can be largely attributed to the higher surface-to-volume ratio achieved in our microfluidic experiments; double that observed for bulk extractions under the conditions employed. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Kolar, Elisabeth; Catthoor, Rik P. R.; Kriel, Frederik H.; Sedev, Rossen; Priest, Craig] Univ S Australia, Future Ind Inst, Mawson Lakes, SA 5095, Australia. [Middlemas, Scott; Klier, Eric] Army Res Lab, Aberdeen, MD 21005 USA. [Hatch, Gareth] Technol Met Res LLC, 180 S Western Ave 150, Carpentersville, IL 60110 USA. RP Priest, C (reprint author), Univ S Australia, Future Ind Inst, Mawson Lakes, SA 5095, Australia. EM craig.priest@unisa.edu.au RI Priest, Craig/F-4212-2013 OI Priest, Craig/0000-0002-8861-2161 FU US Army Research Laboratory [W911NF-10-2-0098]; Government of South Australia [PRIF IRGP18]; University of South Australia FX Financial support from the US Army Research Laboratory via Prime Award W911NF-10-2-0098, the Government of South Australia (PRIF IRGP18), and the University of South Australia, is gratefully acknowledged. Part of this work was performed at the SA node of the Australian National Fabrication Facility, supported by the National Collaborative Research Infrastructure Strategy. Technical assistance from Dipankar Chugh and Donghoon Chang is warmly acknowledged. NR 32 TC 1 Z9 1 U1 6 U2 25 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0009-2509 EI 1873-4405 J9 CHEM ENG SCI JI Chem. Eng. Sci. PD JUL 12 PY 2016 VL 148 BP 212 EP 218 DI 10.1016/j.ces.2016.04.009 PG 7 WC Engineering, Chemical SC Engineering GA DK5TM UT WOS:000374983400017 ER PT J AU Hsieh, AJ Chantawansri, TL Hu, WG Cain, J Yu, JH AF Hsieh, Alex J. Chantawansri, Tanya L. Hu, Weiguo Cain, Jason Yu, Jian H. TI New insight into the influence of molecular dynamics of matrix elastomers on ballistic impact deformation in UHMWPE composites SO POLYMER LA English DT Article DE Molecular dynamics; Solid-state NMR; Matrix elastomers; Polyurethane; poly(urethane urea); UHMWPE prepregs; Ballistic impact ID POLY(URETHANE UREA) ELASTOMERS; SOLID-STATE NMR; POLYETHYLENE FIBERS; DOMAIN SIZES; MICROSTRUCTURE; INTERFACE; COPOLYMER; POLYUREA; PHASE AB The use of solid-state nuclear magnetic resonance (ssNMR) spectroscopy as a technique for probing and interpretation of the molecular dynamics in select ultrahigh molecular weight poly(ethylene) (UHMWPE) fibers based prepreg materials is investigated. In particular, ssNMR is used to differentiate the influence of molecular dynamics associated with matrix elastomers. Polyurethane and Kraton (R) based elastomers are used in commercial UHMWPE prepregs. The H-1 wideline spectra clearly revealed greater mobility associated with the molecular dynamics of Kraton (R) elastomers than that of polyurethane; this is consistent when comparing prepregs from different manufacturers. These observations corroborate well with the extent of back face deformation in UHMWPE composites when engaged by projectiles, where polyurethane matrix elastomers exhibit greater resistance. Select bulk elastomers were also considered to highlight the dynamic stiffening characteristics associated with matrix elastomers, where results further substantiate the importance of the molecular attributes on the overall dynamic deformation response in these composites. Published by Elsevier Ltd. C1 [Hsieh, Alex J.; Chantawansri, Tanya L.] US Army, Res Lab, RDRL WMM G, Aberdeen Proving Ground, MD 21005 USA. [Hu, Weiguo] Univ Massachusetts, Dept Polymer Sci & Engn, Amherst, MA 01003 USA. [Cain, Jason] US Army, Res Lab, RDRL WMM A, Aberdeen Proving Ground, MD 21005 USA. [Yu, Jian H.] US Army, Res Lab, RDRL WMM C, Aberdeen Proving Ground, MD 21005 USA. [Cain, Jason] TKC Global Inc, Suite 400 North,13873 Pk Ctr Rd, Herndon, VA 20171 USA. RP Hsieh, AJ (reprint author), US Army, Res Lab, RDRL WMM G, Aberdeen Proving Ground, MD 21005 USA. EM alex.j.hsieh.civ@mail.mil FU Army Research Laboratory (ARL) Director's Research Initiative program [FY11-WMR-029]; ARO [W911NF-14-1-0204, W911NF-15-1-0534]; Army [W911NF-07-D-0004] FX AJH and TLC acknowledge funding support from the Army Research Laboratory (ARL) Director's Research Initiative program (FY11-WMR-029), where an innovative idea on microstructure-mediated tunable molecular dynamics derived from basic research findings is transitioned to support the design of hierarchical elastomers as matrix/interlayer for a broad range of composite applications. AJH acknowledges Dr. James Zheng, Chief Scientist of U.S. Army PEO Soldier Systems, for his endorsement of this research initiative on UHMWPE composites, also would like to thank Honeywell Specialty Materials for providing the Spectra Shield II (R) SR-3124 and SR-3136 prepreg materials, as well as Mr. Jason Parker of U.S. Natick Soldier Systems Center for the Dyneema HB-50 and HB-80 prepregs. WH and AJH would acknowledge the ARO funding for WH(W911NF-14-1-0204 and W911NF-15-1-0534) to facilitate collaboration on ssNMR. AJH also thank Dr. Norm Rice of Triton Systems, Inc. (Chelmsford, MA) for providing PUU materials, under a funded project through Institute for Soldier Nanotechnologies which was established and funded by the Army, under contract W911NF-07-D-0004. NR 29 TC 1 Z9 1 U1 10 U2 28 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 EI 1873-2291 J9 POLYMER JI Polymer PD JUL 11 PY 2016 VL 95 BP 52 EP 61 DI 10.1016/j.polymer.2016.04.048 PG 10 WC Polymer Science SC Polymer Science GA DM2BY UT WOS:000376152400007 ER PT J AU Larsen, EC Devidas, M Chen, S Salzer, WL Raetz, EA Loh, ML Mattano, LA Cole, C Eicher, A Haugan, M Sorenson, M Heerema, NA Carroll, AA Gastier-Foster, JM Borowitz, MJ Wood, BL Willman, CL Winick, NJ Hunger, SP Carroll, WL AF Larsen, Eric C. Devidas, Meenakshi Chen, Si Salzer, Wanda L. Raetz, Elizabeth A. Loh, Mignon L. Mattano, Leonard A., Jr. Cole, Catherine Eicher, Alisa Haugan, Maureen Sorenson, Mark Heerema, Nyla A. Carroll, Andrew A. Gastier-Foster, Julie M. Borowitz, Michael J. Wood, Brent L. Willman, Cheryl L. Winick, Naomi J. Hunger, Stephen P. Carroll, William L. TI Dexamethasone and High-Dose Methotrexate Improve Outcome for Children and Young Adults With High-Risk B-Acute Lymphoblastic Leukemia: A Report From Children's Oncology Group Study AALL0232 SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID MINIMAL RESIDUAL DISEASE; BFM STUDY-GROUP; CONSECUTIVE TRIALS; CANCER GROUP; CHILDHOOD; PREDNISOLONE; ASPARAGINASE; ADOLESCENTS; PHARMACOKINETICS; CORTICOSTEROIDS AB Purpose Survival for children and young adults with high-risk B-acute lymphoblastic leukemia has improved significantly, but 20% to 25% of patients are not cured. Children's Oncology Group study AALL0232 tested two interventions to improve survival. Patients and Methods Between January 2004 and January 2011, AALL0232 enrolled 3,154 participants 1 to 30 years old with newly diagnosed high-risk B-acute lymphoblastic leukemia. By using a 2 3 2 factorial design, 2,914 participants were randomly assigned to receive dexamethasone (14 days) versus prednisone (28 days) during induction and high-dose methotrexate versus Capizzi escalating-dose methotrexate plus pegaspargase during interim maintenance 1. Results Planned interim monitoring showed the superiority of the high-dose methotrexate regimens, which exceeded the predefined boundary and led to cessation of enrollment in January 2011. At that time, participants randomly assigned to high-dose methotrexate during interim maintenance 1 versus those randomly assigned to Capizzi methotrexate had a 5-year event-free survival (EFS) of 82% versus 75.4% (P=.006). Mature final data showed 5-year EFS rates of 79.6% for high-dose methotrexate and 75.2% for Capizzi methotrexate (P=.008). High-dose methotrexate decreased both marrow and CNS recurrences. Patients 1 to 9 years old who received dexamethasone and high-dose methotrexate had a superior outcome compared with those who received the other three regimens (5-year EFS, 91.2% v 83.2%, 80.8%, and 82.1%; P=.015). Older participants derived no benefit from dexamethasone during induction and experienced excess rates of osteonecrosis. Conclusion High-dose methotrexate is superior to Capizzi methotrexate for the treatment of high-risk B-acute lymphoblastic leukemia, with no increase in acute toxicity. Dexamethasone given during induction benefited younger children but provided no benefit and was associated with a higher risk of osteonecrosis among participants 10 years and older. (C) 2016 by American Society of Clinical Oncology C1 [Larsen, Eric C.] Maine Childrens Canc Program, 100 Campus Dr, Scarborough, ME 04074 USA. [Devidas, Meenakshi; Chen, Si] Univ Florida, Gainesville, FL USA. [Salzer, Wanda L.] US Army Med Res & Mat Command, Frederick, MD USA. [Borowitz, Michael J.] Johns Hopkins Med Inst, Baltimore, MD 21205 USA. [Raetz, Elizabeth A.] Univ Utah, Salt Lake City, UT USA. [Loh, Mignon L.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Mattano, Leonard A., Jr.] HARP Pharma Consulting, Mystic, CT USA. [Cole, Catherine] Univ Western Australia, Princess Margaret Hosp Children, Perth, WA 6009, Australia. [Eicher, Alisa] Doernbecher Childrens Hosp, Portland, OR USA. [Haugan, Maureen] Ann & Robert H Lurie Childrens Hosp Chicago, Chicago, IL 60611 USA. [Sorenson, Mark] Univ Iowa Hosp & Clin, Iowa City, IA 52242 USA. [Heerema, Nyla A.; Gastier-Foster, Julie M.] Ohio State Univ, Sch Med, Columbus, OH 43210 USA. [Carroll, Andrew A.] Univ Alabama Birmingham, Birmingham, AL USA. [Wood, Brent L.] Univ Washington, Seattle, WA 98195 USA. [Willman, Cheryl L.] Univ New Mexico, Albuquerque, NM 87131 USA. [Winick, Naomi J.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA. [Hunger, Stephen P.] Univ Penn, Childrens Hosp Philadelphia, Philadelphia, PA USA. [Carroll, William L.] NYU, Med Ctr, New York, NY 10016 USA. RP Larsen, EC (reprint author), Maine Childrens Canc Program, 100 Campus Dr, Scarborough, ME 04074 USA. EM larsee1@mmc.org FU Children's Oncology Group Chairs Operations [U10 CA98543, U10 CA180886]; Children's Oncology Group Statistics and Data Center [U10 CA098413, U10 CA180899] FX Supported by Children's Oncology Group Chairs Operations grants U10 CA98543 and U10 CA180886 and Children's Oncology Group Statistics and Data Center grants U10 CA098413 and U10 CA180899. NR 33 TC 4 Z9 4 U1 1 U2 1 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD JUL 10 PY 2016 VL 34 IS 20 BP 2380 EP U129 DI 10.1200/JCO.2015.62.4544 PG 15 WC Oncology SC Oncology GA DQ3TW UT WOS:000379127400009 PM 27114587 ER PT J AU Deleage, C Schuetz, A Alvord, WG Johnston, L Hao, XP Morcock, DR Rerknimitr, R Fletcher, JLK Puttamaswin, S Phanuphak, N Dewar, R McCune, JM Sereti, I Robb, M Kim, JH Schacker, TW Hunt, P Lifson, JD Ananworanich, J Estes, JD AF Deleage, Claire Schuetz, Alexandra Alvord, W. Gregory Johnston, Leslie Hao, Xing-Pei Morcock, David R. Rerknimitr, Rungsun Fletcher, James L. K. Puttamaswin, Suwanna Phanuphak, Nittaya Dewar, Robin McCune, Joseph M. Sereti, Irini Robb, Merlin Kim, Jerome H. Schacker, Timothy W. Hunt, Peter Lifson, Jeffrey D. Ananworanich, Jintanat Estes, Jacob D. CA RV254 SEARCH Study Grp RV304 SEARCH Study Grp TI Impact of early cART in the gut during acute HIV infection SO JCI INSIGHT LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; T-CELL-ACTIVATION; MUCOSAL IMMUNE RECONSTITUTION; ACTIVE ANTIRETROVIRAL THERAPY; LYMPHOID-TISSUE; MICROBIAL TRANSLOCATION; LENTIVIRAL INFECTIONS; SYSTEMIC INFLAMMATION; EPITHELIAL BARRIER; VIRAL RESERVOIRS AB Early after HIV infection there is substantial depletion of CD4(+) T cells in the gastrointestinal (GI) tract lamina propria (LP), with associated epithelial barrier damage, leading to microbial translocation and systemic inflammation and immune activation. In this study, we analyzed these early events in the GI tract in a cohort of Thai acute HIV-infected patients and determined the effect of early combination antiretroviral treatment (cART). HIV-uninfected and chronically and acutely HIV-infected patients at different Fiebig stages (I-V) underwent colonic biopsies and then received cART. Immunohistochemistry and quantitative image analysis were performed on cross-sectional and longitudinal colon biopsy specimens (day 0 to week 96) to measure GI tract damage (infiltration of polymorphonuclear cells), inflammation (Mx1, TNF-alpha), immune activation (Ki-67), and the CD4(+) T cell population in the LP. The magnitude of GI tract damage, immune activation, and inflammation was significantly increased, with significantly depleted CD4(+) T cells in the LP in all acutely infected groups prior to cART compared with HIV-uninfected control participants. While most patients treated during acute infection resolved GI tract inflammation and immune activation back to baseline levels after 24 weeks of cART, most acutely infected participants did not restore their CD4(+) T cells after 96 weeks of cART. C1 [Deleage, Claire; Johnston, Leslie; Morcock, David R.; Lifson, Jeffrey D.; Estes, Jacob D.] Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, AIDS & Canc Virus Program, Frederick, MD USA. [Schuetz, Alexandra] Armed Forces Res Inst Med Sci, Dept Retrovirol, Bangkok, Thailand. [Schuetz, Alexandra; Robb, Merlin; Kim, Jerome H.; Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Bethesda, MD USA. [Alvord, W. Gregory] Data Management Serv Inc, Stat Consulting, Frederick, MD USA. [Hao, Xing-Pei] Leidos Biomedical Res Inc, Frederick Natl Lab Canc Res, Pathol & Histotechnol Lab, Frederick, MD USA. [Rerknimitr, Rungsun] Chulalongkorn Univ, Bangkok, Thailand. [Fletcher, James L. K.; Puttamaswin, Suwanna; Phanuphak, Nittaya; Kim, Jerome H.; Ananworanich, Jintanat] SEARCH, Bangkok, Thailand. [Fletcher, James L. K.; Puttamaswin, Suwanna; Phanuphak, Nittaya] Thai Red Cross AIDS Res Ctr, Bangkok, Thailand. [Dewar, Robin] NCI, Virus Isolat & Serol Lab, Appl & Dev Res Directorate, Sci Applicat Int Corp,Frederick Inc,Frederick Can, Frederick, MD 21701 USA. [McCune, Joseph M.] UCSF, Dept Med, Div Expt Med, San Francisco, CA USA. [Sereti, Irini] NIAID, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. [Kim, Jerome H.] Int Vaccine Inst, Seoul, South Korea. [Schacker, Timothy W.] Univ Minnesota, Dept Med, Box 736 UMHC, Minneapolis, MN 55455 USA. [Hunt, Peter] UCSF, Dept Med, Posit Hlth Program, San Francisco, CA USA. RP Estes, JD (reprint author), Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, 1050 Boyles St,Bldg 535,Rm 411, Frederick, MD 21702 USA. EM estesj@mail.nih.gov NR 71 TC 2 Z9 2 U1 1 U2 1 PU AMER SOC CLINICAL INVESTIGATION INC PI ANN ARBOR PA 35 RESEARCH DR, STE 300, ANN ARBOR, MI 48103 USA SN 2379-3708 J9 JCI INSIGHT JI JCI Insight PD JUL 7 PY 2016 VL 1 IS 10 AR e87065 DI 10.1172/jci.insight.87065 PG 18 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA EB1LL UT WOS:000387113300015 ER PT J AU DiMarco, BN Motley, TC Balok, RS Li, GC Siegler, MA O'Donnell, RM Hu, K Meyer, GJ AF DiMarco, Brian N. Motley, Tyler C. Balok, Ryan S. Li, Guocan Siegler, Maxime A. O'Donnell, Ryan M. Hu, Ke Meyer, Gerald J. TI A Distance Dependence to Lateral Self-Exchange across Nanocrystalline TiO2. A Comparative Study of Three Homologous Ru-III/II Polypyridyl Compounds SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID SENSITIZED SOLAR-CELLS; MESOSCOPIC OXIDE-FILMS; ELECTRON-TRANSFER; HOLE TRANSFER; THIN-FILMS; TRANSPORT; DYES; INTERFACES; MONOLAYER; COMPLEXES AB Self-exchange intermolecular Ru-III/II electron transfer, a process commonly referred to as "hole-hopping", is of great interest as it provides a means of charge transport across the surface of nanocrystalline (anatase) TiO2 mesoporous thin films without the loss of free energy. This process was characterized by cyclic voltammetry and chronoabsorptometry for three homologous Ru diimine compounds of the general form [Ru(LL)(2)(dcbH(2))](PF6)(2), where LL is 2,2'-bipyridine (bpy), 4,4'-dimethyl-2,2'-bipyridine (dmb), or 4,4'-di-tert-butyl-2,2'-bipyridine (dtb) and dcbH(2) is 2,2'-bipyridyl-4,4'-dicarboxylic acid. Apparent electron diffusion coefficients, D, abstracted from this data increased with dtb < bpy < dmb. Both techniques were consistent with this trend, despite differences in the magnitude of D between the two methods. Temperature dependent measurements revealed an activation barrier for electron self-exchange of 250 +/- 50 meV that was within this error the same for all three diimine compounds, suggesting the total reorganization energy, lambda, was also the same. Application of Marcus theory, with the assumption that the 900 +/- 100 meV total reorganization energy for self-exchange electron transfer was independent of the Ru compound, revealed that the electronic coupling matrix element, H-AB, followed the trend dtb (0.02 meV) < bpy (0.07 meV) < dmb (0.10 meV). The results indicate that insulating side groups placed on redox active molecules can be utilized to tune the electronic coupling and hence self-exchange rate constants without significantly altering the reorganization energy for electron transfer on TiO2 surfaces. C1 [DiMarco, Brian N.; Motley, Tyler C.; Balok, Ryan S.; Li, Guocan; O'Donnell, Ryan M.; Hu, Ke; Meyer, Gerald J.] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA. [Siegler, Maxime A.] Johns Hopkins Univ, Dept Chem, 3400 North Charles St, Baltimore, MD 21218 USA. [O'Donnell, Ryan M.] Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Meyer, GJ (reprint author), Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA. EM gjmeyer@email.unc.edu RI O'Donnell, Ryan/G-5948-2010 OI O'Donnell, Ryan/0000-0002-3565-9783 FU National Science Foundation (NSF) [CHE-1213357]; NSF Graduate Research Fellowship Program [DGE-1144081] FX The research is supported by the National Science Foundation (NSF) under Award CHE-1213357 and the NSF Graduate Research Fellowship Program under Grant No. DGE-1144081 (T.C.M.). The authors would like to thank Evan E. Beauvilliers for assistance in preparing the TOC and Scheme 3. NR 29 TC 1 Z9 1 U1 3 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD JUL 7 PY 2016 VL 120 IS 26 BP 14226 EP 14235 DI 10.1021/acs.jpcc.6b04438 PG 10 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA DQ8JL UT WOS:000379457000040 ER PT J AU Li, P Moon, SY Guelta, MA Harvey, SP Hupp, JT Farha, OK AF Li, Peng Moon, Su-Young Guelta, Mark A. Harvey, Steven P. Hupp, Joseph T. Farha, Omar K. TI Encapsulation of a Nerve Agent Detoxifying Enzyme by a Mesoporous Zirconium Metal-Organic Framework Engenders Thermal and Long-Term Stability SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY LA English DT Article ID ORGANOPHOSPHORUS ACID ANHYDROLASE; HYDROLYSIS; ADSORPTION; IMMOBILIZATION; DETOXIFICATION; BIOCATALYSIS; DESIGN; SILICA; VX AB Immobilized enzymes typically have greater thermal and operational stability than their soluble form. Here we report that for the first time, a nerve agent detoxifying enzyme, organophosphorus acid anhydrolase (OPAA), has been successfully encapsulated into a water stable zirconium metal-organic framework (MOF). This MOF features a hierarchical mesoporous channel structure and exhibits a 12 wt % loading capacity of OPAA. The thermal and long-term stabilities of OPAA are both significantly enhanced after immobilization. C1 [Li, Peng; Moon, Su-Young; Hupp, Joseph T.; Farha, Omar K.] Northwestern Univ, Dept Chem & Chem & Biol Engn, 2145 Sheridan Rd, Evanston, IL 60208 USA. [Guelta, Mark A.; Harvey, Steven P.] US Army Edgewood Chem Biol Ctr, RDCB DRC C, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. [Farha, Omar K.] King Abdulaziz Univ, Dept Chem, Fac Sci, Jeddah 21589, Saudi Arabia. RP Farha, OK (reprint author), Northwestern Univ, Dept Chem & Chem & Biol Engn, 2145 Sheridan Rd, Evanston, IL 60208 USA.; Farha, OK (reprint author), King Abdulaziz Univ, Dept Chem, Fac Sci, Jeddah 21589, Saudi Arabia. EM o-farha@northwestern.edu RI Li, Peng/I-3316-2014 OI Li, Peng/0000-0002-4273-4577 FU DTRA [HDTRA1-14-1-0014] FX O.K.F. and J.T.H. gratefully acknowledge DTRA for financial support (HDTRA1-14-1-0014). The authors thank Dr. Brian Pate (Joint Science & Technology Office for Chemical & Biological Defense, Defense Threat Reduction Agency) for helpful discussions. S.P.H. and M.A.G. gratefully acknowledge DTRA for financial support. NR 36 TC 7 Z9 8 U1 57 U2 116 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0002-7863 J9 J AM CHEM SOC JI J. Am. Chem. Soc. PD JUL 6 PY 2016 VL 138 IS 26 BP 8052 EP 8055 DI 10.1021/jacs.6b03673 PG 4 WC Chemistry, Multidisciplinary SC Chemistry GA DQ8JA UT WOS:000379455600003 PM 27341436 ER PT J AU Malloy, T Trump, BD Linkov, I AF Malloy, Timothy Trump, Benjamin D. Linkov, Igor TI Risk-Based and Prevention-Based Governance for Emerging Materials SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Editorial Material C1 [Malloy, Timothy] UCLA Sch Law, Los Angeles, CA 90095 USA. [Trump, Benjamin D.] Univ Michigan, Sch Publ Hlth, Ann Arbor, MI 48109 USA. [Trump, Benjamin D.; Linkov, Igor] US Army Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Linkov, I (reprint author), US Army Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM Igor.Linkov@usace.army.mil NR 5 TC 1 Z9 1 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JUL 5 PY 2016 VL 50 IS 13 SI SI BP 6822 EP 6824 DI 10.1021/acs.est.6b02550 PG 3 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA DQ7DE UT WOS:000379366300028 PM 27305964 ER PT J AU Wang, CJ Gong, ZY Pan, YL Videen, G AF Wang, Chuji Gong, Zhiyong Pan, Yong-Le Videen, Gorden TI Laser pushing or pulling of absorbing airborne particles SO APPLIED PHYSICS LETTERS LA English DT Article ID TRACTOR BEAM; OPTICAL FORCES; RAMAN-SPECTRA; AIR; MANIPULATION; TRAP AB A single absorbing particle formed by carbon nanotubes in the size range of 10-50 mu m is trapped in air by a laser trapping beam and concurrently illuminated by another laser manipulating beam. When the trapping beam is terminated, the movement of the particle controlled by the manipulating beam is investigated. We report our observations of light-controlled pushing and pulling motions. We show that the movement direction has little relationship with the particle size and manipulating beam's parameters but is dominated by the particle's orientation and morphology. With this observation, the controllable optical manipulation is now able to be generalized to arbitrary particles, including irregularly shaped absorbing particles that are shown in this work. Published by AIP Publishing. C1 [Wang, Chuji; Gong, Zhiyong] Mississippi State Univ, Starkville, MS 39759 USA. [Pan, Yong-Le; Videen, Gorden] US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Wang, CJ (reprint author), Mississippi State Univ, Starkville, MS 39759 USA. EM cw175@msstate.edu FU U.S. Army Research Office [W911NF-13-1-0429, W911NF-12-2-0019]; U.S. Army Research Laboratory mission funds; Defense Threat Reduction Agency (DTRA) [HDTRS1518237] FX This research was supported by the U.S. Army Research Office Grant Nos. W911NF-13-1-0429 and W911NF-12-2-0019, the U.S. Army Research Laboratory mission funds, and the Defense Threat Reduction Agency (DTRA) under HDTRS1518237. NR 30 TC 0 Z9 0 U1 5 U2 10 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUL 4 PY 2016 VL 109 IS 1 AR 011905 DI 10.1063/1.4955476 PG 5 WC Physics, Applied SC Physics GA DR0GW UT WOS:000379587000014 ER PT J AU Shen, JH Gartnerova, V Kecskes, LJ Kondoh, K Jager, A Wei, QM AF Shen, Jianghua Gartnerova, Viera Kecskes, Laszlo J. Kondoh, Katsuyoshi Jager, Aleg Wei, Qiuming TI Residual stress and its effect on the mechanical properties of Y-doped Mg alloy fabricated via back-pressure assisted equal channel angular pressing (ECAP-BP) SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Magnesium; Equal channel angular pressing (ECAP); Rare earth; Relaxation tests; Activation volume ID SOLIDIFICATION POWDER-METALLURGY; MAGNESIUM ALLOY; ROOM-TEMPERATURE; DEFORMATION-BEHAVIOR; STRAIN-RATE; PURE MAGNESIUM; NONBASAL SLIP; GRAIN-SIZE; TEXTURE; EXTRUSION AB In this study, pure magnesium (Mg) and Mg-0.6 wt% yttrium (Y) binary alloy were fabricated via casting followed by room temperature equal channel angular pressing (ECAP) using an applied back pressure (BP). Microstructural examination after ECAP-BP revealed a fine-grained Mg-Y alloy with a high residual stress level, whereas, the pure Mg exhibited a well-recrystallized microstructure with uniform and equiaxed grains, but retaining very little residual stress. The Y atoms were present in the Mg matrix as solid solutes and acted as dislocation and grain boundary blockers, thus suppressing dynamic recovery and/or recrystallization during the ECAP process. The Mg-Y alloy had an average grain size of similar to 400 nm, approximately one order smaller than that of pure Mg. The combination of high residual stress and ultrafine grains of the Mg-Y alloy gave rise to a significant difference in its mechanical behavior from that of the pure Mg, under both quasi-static and dynamic compressive loading. (C) 2016 Elsevier B.V. All rights reserved. C1 [Shen, Jianghua; Wei, Qiuming] Univ N Carolina, Dept Mech Engn, Charlotte, NC 28223 USA. [Shen, Jianghua] Northwestern Polytech Univ, Sch Aeronaut, Xian 710072, Peoples R China. [Gartnerova, Viera; Jager, Aleg] ASCR, Inst Phys, Lab Nanostruct & Nanomat, Na Slovance 2, CZ-18221 Prague 8, Czech Republic. [Kecskes, Laszlo J.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Shen, Jianghua; Kondoh, Katsuyoshi] Osaka Univ, Joining & Welding Res Inst, 11-1 Mihogaoka, Osaka 5670047, Japan. RP Shen, JH (reprint author), Univ N Carolina, Dept Mech Engn, Charlotte, NC 28223 USA.; Shen, JH (reprint author), Northwestern Polytech Univ, Sch Aeronaut, Xian 710072, Peoples R China.; Jager, A (reprint author), ASCR, Inst Phys, Lab Nanostruct & Nanomat, Na Slovance 2, CZ-18221 Prague 8, Czech Republic.; Shen, JH (reprint author), Osaka Univ, Joining & Welding Res Inst, 11-1 Mihogaoka, Osaka 5670047, Japan. EM j_shen@live.cn; jager@fzu.cz RI Shen, Jianghua/C-2586-2013; Wei, Qiuming/B-7579-2008; Gartnerova, Viera/G-5937-2014 OI Shen, Jianghua/0000-0003-1017-0698; Gartnerova, Viera/0000-0003-4356-8408 FU US Army Research Laboratory [W911QX-08-0073, W911NF-14-2-0061]; China Scholarship Council; 111 project [B07050]; GACR [GBP108/12/G043] FX This work is supported by the US Army Research Laboratory under Contract Nos. W911QX-08-0073 and W911NF-14-2-0061. J.H. Shen sincerely appreciates the financial support from China Scholarship Council and the 111 project (No. B07050). A. Jager and V. Gartnerova appreciate financial support offered by GACR GBP108/12/G043. NR 54 TC 1 Z9 1 U1 10 U2 15 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 EI 1873-4936 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD JUL 4 PY 2016 VL 669 BP 110 EP 117 DI 10.1016/j.msea.2016.05.067 PG 8 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA DQ1HD UT WOS:000378951200014 ER PT J AU Antony, SJ Parikh, MS Soto-Ruiz, E Cameron, C Mody, R AF Antony, Suresh J. Parikh, Monisha S. Soto-Ruiz, Enrique Cameron, Craig Mody, Rupapal TI Extended-Spectrum Beta-Lactamase Infections in Orthopedic-Related Devices and Prosthetic Joints SO ORTHOPEDICS LA English DT Article ID RISK-FACTORS; ANTIBIOTIC-RESISTANCE; TOTAL HIP; ARTHROPLASTY; ENTEROBACTERIACEAE; FLUOROQUINOLONE; EPIDEMIOLOGY; COMBINATION; CHALLENGE; BIOFILM AB Extended-spectrum beta-lactamase-producing Enterobacteriaceae have increasingly become a public health issue in a variety of infections, including urinary tract infections and postoperative infections. The complications that occur due to these organisms in bone, joint, and prosthetic joints have not been well defined. This study reviewed the clinical characteristics, risk factors, and outcomes of patients with extended-spectrum beta-lactamase-producing Enterobacteriaceae infections of prosthetic joints or orthopedic-related hardware. Six infections met the inclusion criteria that resulted in a 100% failure rate when the hardware or prosthetic joint was not replaced initially. However, when the hardware or prosthetic joint was replaced, all of the patients did well. The use of carbapenems remains effective in these cases. C1 [Antony, Suresh J.; Parikh, Monisha S.] Texas Tech Univ, Hlth Sci Ctr, Paul L Foster Sch Med, Div Infect Dis,Dept Med, 1205 N Oregon, El Paso, TX 79902 USA. [Soto-Ruiz, Enrique] Univ Texas El Paso, Med Ctr, El Paso, TX 79968 USA. [Cameron, Craig] DD Eisenhower Med Ctr, Dept Orthoped, Ft Gordon, GA USA. [Mody, Rupapal] William Beaumont Med Ctr, Dept Med, El Paso, TX USA. RP Antony, SJ (reprint author), Texas Tech Univ, Hlth Sci Ctr, Paul L Foster Sch Med, Div Infect Dis,Dept Med, 1205 N Oregon, El Paso, TX 79902 USA. EM suresh.antony@att.net NR 30 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0147-7447 EI 1938-2367 J9 ORTHOPEDICS JI Orthopedics PD JUL-AUG PY 2016 VL 39 IS 4 BP E668 EP E673 DI 10.3928/01477447-20160606-07 PG 6 WC Orthopedics SC Orthopedics GA EJ3IJ UT WOS:000393105500012 PM 27286048 ER PT J AU Owens, BD Cameron, KL Clifton, KB Svoboda, SJ Wolf, JM AF Owens, Brett D. Cameron, Kenneth L. Clifton, Kari B. Svoboda, Steven J. Wolf, Jennifer Moriatis TI Association Between Serum Relaxin and Subsequent Shoulder Instability SO ORTHOPEDICS LA English DT Article ID ANTERIOR CRUCIATE LIGAMENT; INFERIOR CAPSULAR-SHIFT; UNITED-STATES; JOINT LAXITY; MULTIDIRECTIONAL INSTABILITY; EPIDEMIOLOGY; YOUNG; HISTORY; INJURY; HYPERMOBILITY AB Ligamentous laxity correlates with shoulder instability. Relaxin is a hormone that has been linked to laxity in the knee and has been shown to be a risk factor for anterior cruciate ligament (ACL) injury. This study prospectively evaluated the association between relaxin and acute shoulder instability. A prospective cohort study of 1050 young athletes was performed between 2006 and 2010. The authors conducted a nested case-control analysis within this cohort to evaluate the association between preinjury serum relaxin concentration and the likelihood of subsequent shoulder instability. The study compared 53 patients who had shoulder instability and 53 control subjects who were matched for sex, age, height, and weight. The serum relaxin concentration in preinjury baseline samples was tested with enzyme-linked immunosorbent assay analysis in duplicate. Independent t tests were performed to identify differences in mean serum relaxin concentration between patients with shoulder instability and uninjured control subjects. Logistic regression was used to evaluate whether preinjury baseline serum relaxin concentration was associated with the subsequent likelihood of shoulder instability. Of the 53 patients with instability, 13 (25%) had a detectable serum relaxin concentration compared with 9 (17%) of uninjured control subjects (P=.34). Mean serum relaxin concentration in the injury group was 3.69 +/- 1.78 pg/mL and 2.20 +/- 0.97 pg/mL in uninjured control subjects (P=.02). Increased serum relaxin concentration was associated with the subsequent likelihood of acute shoulder instability. Subjects were 2.18 times (odds ratio, 2.18; 95% confidence interval, 1.01-4.76) more likely to have acute shoulder instability during the follow-up period for every 1-pg/mL increase in serum relaxin concentration at baseline. The findings suggest that serum relaxin concentration is associated with a risk of subsequent shoulder instability in young athletes. Further research on the role of relaxin in shoulder instability is warranted. C1 [Owens, Brett D.; Cameron, Kenneth L.; Svoboda, Steven J.] Keller Army Hosp, West Point, NY USA. [Owens, Brett D.] Brown Alpert Med Sch, Dept Orthopaed, 100 Butler Dr, Providence, RI 02906 USA. [Clifton, Kari B.; Wolf, Jennifer Moriatis] Univ Connecticut, Farmington, CT USA. RP Owens, BD (reprint author), Brown Alpert Med Sch, Dept Orthopaed, 100 Butler Dr, Providence, RI 02906 USA. EM owensbrett@gmail.com OI Cameron, Kenneth/0000-0002-6276-4482 NR 34 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0147-7447 EI 1938-2367 J9 ORTHOPEDICS JI Orthopedics PD JUL-AUG PY 2016 VL 39 IS 4 BP E724 EP E728 DI 10.3928/01477447-20160421-01 PG 5 WC Orthopedics SC Orthopedics GA EJ3IJ UT WOS:000393105500020 PM 27111077 ER PT J AU Williams, SL Sakib, N Kirisits, MJ Ferron, RD AF Williams, Sarah L. Sakib, Nazmus Kirisits, Mary Jo Ferron, Raissa D. TI Flexural Strength Recovery Induced by Vegetative Bacteria Added to Mortar SO ACI MATERIALS JOURNAL LA English DT Article DE bioinspired; biomineralization; calcium carbonate; flexural strength; self-healing; strength recovery ID SELF-HEALING CONCRETE; CEMENTITIOUS MATERIALS; PERMEABILITY; DURABILITY; PASTEURII; HYDRATION; IMPROVES; CRACKS AB Recent interest has focused on developing a bioinspired, selfhealing concrete in which microorganisms induce calcium carbonate precipitation to repair cracks. Although initial studies in this area have produced promising results, the ability of such microorganisms to restore structural integrity to the material through the recovery of mechanical properties (for example, strength and stiffness) has not been fully addressed. Previous studies have focused primarily on the self-sealing (that is, crack closure) of cracks as indicated by visual observation, ultrasonic test methods, or water permeability. While crack-sealing in concrete is certainly beneficial for durability, a true self-healing concrete should restore structural integrity by providing strength recovery. In the current study, the efficacy of various bacteria-based repair agents for cracked mortar beams was evaluated. Precracked mortar beams subjected to various bacterial treatments exhibited greater flexural strength recovery (8 to 30% recovery) as compared to that of precracked mortar beams without bacteria (3 to 5% recovery). C1 [Williams, Sarah L.] US Army, ERDC, Vicksburg, MS 39180 USA. [Sakib, Nazmus; Kirisits, Mary Jo; Ferron, Raissa D.] Univ Texas Austin, Austin, TX 78712 USA. RP Williams, SL (reprint author), US Army, ERDC, Vicksburg, MS 39180 USA. FU Science, Mathermatics & Research for Transformation (SMART) FX The authors gratefully acknowledge the U.S. Department of Defense. This material is based upon work supported by the Science, Mathermatics & Research for Transformation (SMART) Scholarship for Service Program. NR 32 TC 0 Z9 0 U1 5 U2 5 PU AMER CONCRETE INST PI FARMINGTON HILLS PA 38800 COUNTRY CLUB DR, FARMINGTON HILLS, MI 48331 USA SN 0889-325X EI 1944-737X J9 ACI MATER J JI ACI Mater. J. PD JUL-AUG PY 2016 VL 113 IS 4 BP 523 EP 531 DI 10.14359/51688831 PG 9 WC Construction & Building Technology; Materials Science, Multidisciplinary SC Construction & Building Technology; Materials Science GA EE6CC UT WOS:000389695200014 ER PT J AU Roy, DC Tomblyn, S Isaac, KM Kowalczewski, CJ Burmeister, DM Burnett, LR Christy, RJ AF Roy, Daniel C. Tomblyn, Seth Isaac, Kameel M. Kowalczewski, Christine J. Burmeister, David M. Burnett, Luke R. Christy, Robert J. TI Ciprofloxacin-loaded keratin hydrogels reduce infection and support healing in a porcine partial-thickness thermal burn SO WOUND REPAIR AND REGENERATION LA English DT Article ID WOUND INFECTIONS; SILVER SULFADIAZINE; ANIMAL-MODELS; DRESSINGS; SWINE; OCTYLCYANOACRYLATE; BIOMATERIALS; ABSORPTION; MANAGEMENT; TRIAL AB Infection is a leading cause of morbidity and mortality in burn patients. Current therapies include silver-based creams and dressings, which display limited antimicrobial effectiveness and impair healing. The need exists for a topical, point-of-injury antibiotic treatment that provides sustained antimicrobial activity without impeding wound repair. Fitting this description are keratin-based hydrogels, which are fully biocompatible and support the slow-release of antibiotics. Here we develop a porcine model of an infected partial-thickness burn to test the effects of ciprofloxacin-loaded keratin hydrogels on infection and wound healing. Partial-thickness burns were inoculated with either Pseudomonas aeruginosa or Methicillin-resistant Staphylococcus aureus, resulting in infections that persisted for >2 weeks that exceeded 10(5) and 10(6) cfu per gram of tissue, respectively. Compared to silver sulfadiazine, ciprofloxacin-loaded keratin hydrogel treatment significantly reduced the amount of P. aeruginosa and S. aureus in the burn by >99% on days 4, 7, 11, and 15 postinjury. Further, burns treated with ciprofloxacin-loaded keratin hydrogels exhibited similar healing patterns as uninfected burns with regards to reepithelialization, macrophage recruitment, and collagen deposition and remodeling. The ability of keratin hydrogels to deliver antibiotics to fight infection and support healing of partial-thickness burns make them a strong candidate as a first-line burn therapy. C1 [Roy, Daniel C.; Isaac, Kameel M.; Kowalczewski, Christine J.; Burmeister, David M.; Christy, Robert J.] US Army, Inst Surg Res, Ft Sam Houston, TX USA. [Roy, Daniel C.; Tomblyn, Seth; Kowalczewski, Christine J.; Burnett, Luke R.] KeraNetics LLC, Winston Salem, NC USA. RP Christy, RJ (reprint author), US Army, Inst Surg Res, Extrem Trauma Res & Regenerat Med, 3698 Chambers Pass,BHT1 Bldg 3611,JBSA, Ft Sam Houston, TX 78234 USA. EM robert.j.christy12.civ@mail.mil FU USAMRMC [W81XWH-12-C-0004] FX This material is based upon work supported by the USAMRMC under Contract No. W81XWH-12-C-0004. NR 46 TC 1 Z9 1 U1 4 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1067-1927 EI 1524-475X J9 WOUND REPAIR REGEN JI Wound Repair Regen. PD JUL-AUG PY 2016 VL 24 IS 4 BP 657 EP 668 DI 10.1111/wrr.12449 PG 12 WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery GA EE1SX UT WOS:000389364500004 PM 27238250 ER PT J AU Siegmund, T Barthelat, F Cipra, R Habtour, E Riddick, J AF Siegmund, Thomas Barthelat, Francois Cipra, Raymond Habtour, Ed Riddick, Jaret TI Manufacture and Mechanics of Topologically Interlocked Material Assemblies SO APPLIED MECHANICS REVIEWS LA English DT Review ID MATERIAL-PROPERTY SPACE; ARCHITECTURED MATERIALS; STRUCTURAL-MATERIALS; SOUND-ABSORPTION; HYBRID MATERIALS; SHAPED ELEMENTS; DESIGN; MICROSTRUCTURE; CONSTRUCTION; INDENTATION AB Topologically interlocked material (TIM) systems are load-carrying assemblies of unit elements interacting by contact and friction. TIM assemblies have emerged as a class of architectured materials with mechanical properties not ordinarily found in monolithic solids. These properties include, but are not limited to, high damage tolerance, damage confinement, adaptability, and multifunctionality. The review paper provides an overview of recent research findings on TIM manufacturing and TIM mechanics. We review several manufacturing approaches. Assembly manufacturing processes employ the concept of scaffold as a unifying theme. Scaffolds are understood as auxiliary support structures employed in the manufacturing of TIM systems. It is demonstrated that the scaffold can take multiple forms. Alternatively, processes of segmentation are discussed and demonstrated. The review on mechanical property characteristics links the manufacturing approaches to several relevant material configurations and details recent findings on quasi-static and impact loading, and on multifunctional response. C1 [Siegmund, Thomas; Cipra, Raymond] Purdue Univ, Sch Mech Engn, W Lafayette, IN 47907 USA. [Barthelat, Francois] McGill Univ, Dept Mech Engn, Montreal, PQ H3A 2K6, Canada. [Habtour, Ed; Riddick, Jaret] US Army Res Lab, Vehicle Technol Directorate, RDRL VTM, Aberdeen Proving Ground, MD 21005 USA. RP Siegmund, T (reprint author), Purdue Univ, Sch Mech Engn, W Lafayette, IN 47907 USA. EM siegmund@purdue.edu; francois.barthelat@mcgill.ca; cipra@purdue.edu FU Army Research Office (Grant Mechanics of Multiscale Energy Dissipation in Topologically Interlocked Materials) [11.1 STIR]; AFOSR [FQ8671-090162, FA2386-12-1-3020]; Indiana 21st Century Research and Technology Fund; Natural Sciences and Engineering Research Council of Canada; Fonds de Recherche du Quebec-Nature et Technologies FX T.S. acknowledges the funding by the Army Research Office (Grant Mechanics of Multiscale Energy Dissipation in Topologically Interlocked Materials-11.1 STIR), T.S. and R.J.C. acknowledge the funding via AFOSR (Grants FQ8671-090162 and FA2386-12-1-3020), as well as the Indiana 21st Century Research and Technology Fund. The work of F.B. was supported by an I2I grant from the Natural Sciences and Engineering Research Council of Canada and by the Fonds de Recherche du Quebec-Nature et Technologies. The contributions by A. Anderson (on self assembly) and Z. Wu (on active systems) are gratefully acknowledged. NR 64 TC 0 Z9 0 U1 5 U2 5 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0003-6900 J9 APPL MECH REV JI Appl. Mech. Rev. PD JUL PY 2016 VL 68 IS 4 AR 040803 DI 10.1115/1.4033967 PG 15 WC Mechanics SC Mechanics GA ED3HX UT WOS:000388741300003 ER PT J AU Lesho, E Lin, XX Clifford, R Snesrud, E Onmus-Leone, F Appalla, L Ong, A Maybank, R Nielsen, L Kwak, Y Hinkle, M Turco, J Marin, JA Hooks, S Matthews, S Hyland, S Little, J Waterman, P McGann, P AF Lesho, Emil Lin, Xiaoxu Clifford, Robert Snesrud, Erik Onmus-Leone, Fatma Appalla, Lakshmi Ong, Ana Maybank, Rosslyn Nielsen, Lindsey Kwak, Yoon Hinkle, Mary Turco, John Marin, Juan A. Hooks, Sally Matthews, Stacy Hyland, Stephen Little, Jered Waterman, Paige McGann, Patrick TI From the Battlefield to the Bedside: Supporting Warfighter and Civilian Health With the "ART" of Whole Genome Sequencing for Antibiotic Resistance and Outbreak Investigations SO MILITARY MEDICINE LA English DT Editorial Material ID INTENSIVE-CARE-UNIT; STAPHYLOCOCCUS-AUREUS; PROVIDENCIA-STUARTII; AFGHANISTAN; ACQUISITION; BLA(NDM-1); FACILITY; FUTURE; TRAUMA; IRAQ AB Awareness, responsiveness, and throughput characterize an approach for enhancing the clinical impact of whole genome sequencing for austere environments and for large geographically dispersed health systems. This Department of Defense approach is informing interagency efforts linking antibiograms of multidrug-resistant organisms to their genome sequences in a public database. C1 [Lesho, Emil; Lin, Xiaoxu; Clifford, Robert; Snesrud, Erik; Onmus-Leone, Fatma; Appalla, Lakshmi; Ong, Ana; Maybank, Rosslyn; Nielsen, Lindsey; Kwak, Yoon; Hinkle, Mary; McGann, Patrick] Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. [Turco, John; Marin, Juan A.; Hooks, Sally; Matthews, Stacy; Hyland, Stephen; Little, Jered] Camp Arifjan Kuwait, Apo, AE 09366 USA. [Waterman, Paige] Armed Forces Hlth Surveillance Ctr, Global Emerging Infect Surveillance, 1990 Tech Rd, Silver Spring, MD 20901 USA. RP Lesho, E (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. NR 15 TC 0 Z9 0 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JUL PY 2016 VL 181 IS 7 BP 621 EP 624 DI 10.7205/MILMED-D-15-00197 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA DW5LT UT WOS:000383687400005 PM 27391613 ER PT J AU Wang, Q Ayalew, B Singh, A AF Wang, Qian Ayalew, Beshah Singh, Amandeep TI Control Allocation for Multi-Axle Hub Motor Driven Land Vehicles SO SAE INTERNATIONAL JOURNAL OF ALTERNATIVE POWERTRAINS LA English DT Article ID IN-WHEEL MOTORS; MOTION CONTROL AB This paper outlines a real-time hierarchical control allocation algorithm for multi-axle land vehicles with independent hub motor wheel drives. At the top level, the driver's input such as pedal position or steering wheel position are interpreted into desired global state responses based on a reference model. Then, a locally linearized rigid body model is used to design a linear quadratic regulator that generates the desired global control efforts, i.e., the total tire forces and moments required track the desired state responses. At the lower level, an optimal control allocation algorithm coordinates the motor torques in such a manner that the forces generated at tire-road contacts produce the desired global control efforts under some physical constraints of the actuation and the tire/wheel dynamics. The performance of the proposed control system design is verified via simulation analysis of a 3-axle heavy vehicle with independent hub-motor drives. C1 [Wang, Qian; Ayalew, Beshah] Clemson Univ, Clemson, SC 29631 USA. [Singh, Amandeep] US Army, TARDEC, Warren, MI USA. RP Wang, Q (reprint author), Clemson Univ, Clemson, SC 29631 USA. NR 18 TC 0 Z9 0 U1 3 U2 3 PU SAE INT PI WARRENDALE PA 400 COMMONWEALTH DR, WARRENDALE, PA 15096 USA SN 2167-4191 EI 2167-4205 J9 SAE INT J ALTERN POW JI SAE Int. J. Altern. Powertrains PD JUL PY 2016 VL 5 IS 2 BP 338 EP 347 DI 10.4271/2016-01-1670 PG 10 WC Transportation Science & Technology SC Transportation GA EA3MU UT WOS:000386507800013 ER PT J AU Schwenk, JT Sloan, SD Ivanov, J Miller, RD AF Schwenk, J. Tyler Sloan, Steven D. Ivanov, Julian Miller, Richard D. TI Surface-wave methods for anomaly detection SO GEOPHYSICS LA English DT Article ID CROSS-CORRELATION ANALYSIS; SCATTERED GUIDED-WAVES; SHALLOW OBJECTS; RAYLEIGH-WAVES; SEISMIC DATA; GROUND-ROLL; ATTENUATION; INVERSION; VELOCITY; DESIGN AB Perimeter-defense operations, geohazard assessment, and engineering characterization require the detection and localization of subsurface anomalies. Seismic waves incident upon these discontinuities generate a scattered wavefield. We have developed various surface-wave techniques, currently being fielded, that have consistently delivered accurate and precise results across a wide range of survey parameters and geographical locations. We use the multichannel analysis of surface waves approach to study the multimode Rayleigh wave, the backscatter analysis of surface waves (BASW) method to detect anomalies, 3D visualization for efficient seismic interpretation, BASW correlation for attribute analysis, and instantaneous-amplitude integration in the complex BASW method. Discrete linear moveout functions and f-k filter designs are optimized for BASW considering the fundamental and higher mode dispersion trends of the Rayleigh wave. Synthetic and field data were used to demonstrate multimode BASW and mode separation, which accentuated individual scatter events, and ultimately increased confidence in points of interest. Simple correlation algorithms between fundamental and higher-mode BASW data offer attribute analysis that limits the subjective interpretation of BASW images. Domain sorting and Hilbert transforms allow for 3D visualization and rapid interpretation of an anomaly's wavefield phenomena within an amplitude cube. Furthermore, instantaneous-amplitude analysis can be incorporated into a more robust complex BASW method that forgives velocity-estimation inaccuracies, while requiring less rigorous preprocessing. Our investigations have suggested that a multifaceted surface-wave analysis provides a valuable tool for today's geophysicists to fulfill anomaly-detection survey requirements. C1 [Schwenk, J. Tyler; Sloan, Steven D.] XRI Geophys, Vicksburg, MS USA. [Sloan, Steven D.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Ivanov, Julian; Miller, Richard D.] Kansas Geol Survey, Lawrence, KS 66044 USA. RP Schwenk, JT (reprint author), Primal Innovat, Lake Mary, FL 32746 USA. EM tyler.schwenk@primalinnovation.com; steven.d.sloan@usace.army.mil; jivanov@kgs.ku.edu; rmiller@kgs.ku.edu OI Ivanov, Julian/0000-0002-7099-8051 NR 41 TC 0 Z9 0 U1 1 U2 1 PU SOC EXPLORATION GEOPHYSICISTS PI TULSA PA 8801 S YALE ST, TULSA, OK 74137 USA SN 0016-8033 EI 1942-2156 J9 GEOPHYSICS JI Geophysics PD JUL-AUG PY 2016 VL 81 IS 4 BP EN29 EP EN42 DI 10.1190/GEO2015-0356.1 PG 14 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA EA1GY UT WOS:000386341700024 ER PT J AU Zhou, JY Camacho, M Tang, XD Kushida, CA AF Zhou, Junying Camacho, Macario Tang, Xiangdong Kushida, Clete A. TI A review of neurocognitive function and obstructive sleep apnea with or without daytime sleepiness SO SLEEP MEDICINE LA English DT Review DE Cognitive function; Sleepiness; Obstructive sleep apnea; Therapeutics; Continuous positive airway pressure ID POSITIVE AIRWAY PRESSURE; QUALITY-OF-LIFE; RANDOMIZED CONTROLLED-TRIAL; BRAIN STRUCTURAL-CHANGES; LONG-TERM EFFICACY; COGNITIVE FUNCTION; CPAP TREATMENT; APNOEA/HYPOPNOEA SYNDROME; APNEA/HYPOPNEA SYNDROME; SUBJECTIVE SLEEPINESS AB Excessive daytime sleepiness (EDS) and neurocognitive dysfunction are commonly observed in patients with obstructive sleep apnea (OSA), and these daytime functional deficits can be reversed partly or completely with treatment such as continuous positive airway pressure (CPAP). Although daytime sleepiness is a possible etiology for neurocognitive dysfunction in OSA patients, EDS is not universally present in all patients with OSA. The objective of this review is to summarize the relationship between neurocognitive function and EDS in OSA, as well as the difference in cognitive domains, improvement, and application of CPAP therapy between patients with and without EDS. Two authors independently searched PubMED/Medline, The Cochrane Library and Scopus through May 27, 2015. Sixty-five articles were included in this review. The literature demonstrated a wide range of neurocognitive deficits in OSA patients with EDS, but no more extensive and complex cognitive domains (eg, executive function) in patients without EDS. However, the current literature had very few studies with large sample sizes and extended follow-up that evaluated the effect of CPAP for OSA in patients with and without sleepiness. CPAP failed to improve cognitive dysfunction in OSA patients without EDS after short-term therapy. The evidence suggests that daytime sleepiness possibly relates to the domain and extent of cognitive impairments in OSA, and CPAP therapy has little effect on the improvement of cognitive deficits in OSA patients without EDS. We recommend that additional prospective studies be performed to further quantify the relationship between neurocognitive function in OSA patients with and without EDS. (C) 2016 Elsevier B.V. All rights reserved. C1 [Zhou, Junying; Tang, Xiangdong] Sichuan Univ, West China Hosp, Sleep Med Ctr, Mental Hlth Ctr, Chengdu, Peoples R China. [Zhou, Junying; Camacho, Macario; Kushida, Clete A.] Stanford Hosp & Clin, Div Sleep Med, Dept Psychiat & Behav Sci, 450 Broadway, Redwood City, CA 94063 USA. [Camacho, Macario] Tripler Army Med Ctr, Div Sleep Surg & Med, Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA. RP Kushida, CA (reprint author), Stanford Hosp & Clin, Div Sleep Med, Dept Psychiat & Behav Sci, 450 Broadway, Redwood City, CA 94063 USA.; Tang, XD (reprint author), Sichuan Univ, West China Hosp, Sleep Med Ctr, 28 Dian Xin Nan Jie, Chengdu 610041, Sichuan, Peoples R China. EM xiangdong.tang@gmail.com; clete@stanford.edu FU National Natural Science Foundation of China [81501144, 81530002, 81328010]; National Basic Research Program of China [2015CB856406] FX This work was supported by the National Natural Science Foundation of China (No: 81501144, 81530002 and 81328010) and the National Basic Research Program of China (No: 2015CB856406). NR 118 TC 1 Z9 1 U1 2 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1389-9457 EI 1878-5506 J9 SLEEP MED JI Sleep Med. PD JUL PY 2016 VL 23 BP 99 EP 108 DI 10.1016/j.sleep.2016.02.008 PG 10 WC Clinical Neurology SC Neurosciences & Neurology GA EA2FU UT WOS:000386409000014 PM 27288049 ER PT J AU Schild, KM Hawley, RL Morriss, BF AF Schild, Kristin M. Hawley, Robert L. Morriss, Blaine F. TI Subglacial hydrology at Rink Isbrae, West Greenland inferred from sediment plume appearance SO ANNALS OF GLACIOLOGY LA English DT Article; Proceedings Paper CT International Symposium on Hydrology of Glaciers and Ice Sheets CY JUN, 2015 CL Hofn, ICELAND SP Univ Iceland, Univ Iceland, Inst Earth Sci, Iceland Meteorol Off, Natl Power Co Iceland, Iceland Road & Coastal Adm, Iceland Glaciol Soc, Geoscience Soc Iceland DE plume; melt; subglacial hydrology; tidewater glacier; MODIS; Rink Isbrae; Greenland ID SUPRAGLACIAL LAKE DRAINAGE; SUBMARINE MELT RATES; ICE-SHEET; EAST GREENLAND; SEASONAL VARIABILITY; TIDEWATER GLACIERS; OCEAN INTERACTION; OUTLET GLACIERS; MASS-BALANCE; FJORD AB Marine-terminating outlet glaciers discharge most of the Greenland ice sheet's mass through frontal ablation and meltwater runoff. While calving can be estimated by in situ and remote sensing observations, submarine melting and subglacial meltwater transport are more challenging to quantify. Here we investigate the subglacial hydrology of Rink Isbrae, a fast-flowing West Greenland tidewater glacier, using time-lapse photography, modeled runoff estimates and daily satellite imagery from 2007 to 2011. We find that sediment plumes appear episodically at four distinct locations across the terminus, and last between 2 h and 17 d. This suggests short-term variability in discharge and the existence of persistent pathways. The seasonal onset of sediment plumes occurs before supraglacial lake drainages, shortly after the onset of runoff, and only after the wintertime ice melange has begun disintegrating. Plumes were also visible after the cessation of runoff (23 +/- 5 d), which is indicative of subglacial storage. The lack of either a seasonal velocity change or a correspondence between meltwater availability and plume occurrence suggests that the subglacial system persists in a state of inefficient drainage. Subglacial hydrology at tidewater glaciers is of critical importance in understanding dynamics at the ice front. C1 [Schild, Kristin M.; Hawley, Robert L.; Morriss, Blaine F.] Dartmouth Coll, Hanover, NH 03755 USA. [Morriss, Blaine F.] US Army Corps Engineers, Engn Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Schild, KM (reprint author), Dartmouth Coll, Hanover, NH 03755 USA. EM Kristin.M.Schild.GR@dartmouth.edu NR 74 TC 0 Z9 0 U1 3 U2 3 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 0260-3055 EI 1727-5644 J9 ANN GLACIOL JI Ann. Glaciol. PD JUL PY 2016 VL 57 IS 72 BP 118 EP 127 DI 10.1017/aog.2016.1 PG 10 WC Geography, Physical; Geosciences, Multidisciplinary SC Physical Geography; Geology GA DZ1IT UT WOS:000385592800013 ER PT J AU Barbato, RA Garcia-Reyero, N Foley, K Jones, R Courville, Z Douglas, T Perkins, E Reynolds, CM AF Barbato, Robyn A. Garcia-Reyero, Natalia Foley, Karen Jones, Robert Courville, Zoe Douglas, Thomas Perkins, Edward Reynolds, Charles M. TI Removal of Exogenous Materials from the Outer Portion of Frozen Cores to Investigate the Ancient Biological Communities Harbored Inside SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS LA English DT Article DE Molecular Biology; Issue 113; Permafrost; ice cores; microbial communities; decontamination; qPCR; soil; bacteria; archaea ID PERMAFROST ICE WEDGE; PHYLOGENETIC ANALYSIS; DNA; DIVERSITY; SAMPLES; ALASKA; MODEL; THAW AB The cryosphere offers access to preserved organisms that persisted under past environmental conditions. In fact, these frozen materials could reflect conditions over vast time periods and investigation of biological materials harbored inside could provide insight of ancient environments. To appropriately analyze these ecosystems and extract meaningful biological information from frozen soils and ice, proper collection and processing of the frozen samples is necessary. This is especially critical for microbial and DNA analyses since the communities present may be so uniquely different from modern ones. Here, a protocol is presented to successfully collect and decontaminate frozen cores. Both the absence of the colonies used to dope the outer surface and exogenous DNA suggest that we successfully decontaminated the frozen cores and that the microorganisms detected were from the material, rather than contamination from drilling or processing the cores. C1 [Barbato, Robyn A.; Foley, Karen; Jones, Robert] US Army, Biogeochem Sci Branch, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. [Garcia-Reyero, Natalia; Perkins, Edward] US Army, Environm Proc Branch, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS USA. [Courville, Zoe] US Army, Terr & Cryospher Scienes Branch, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Hanover, NH USA. [Douglas, Thomas; Reynolds, Charles M.] US Army, Biogeochem Sci Branch, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Fairbanks, AK USA. RP Barbato, RA (reprint author), US Army, Biogeochem Sci Branch, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. EM Robyn.A.Barbato@erdc.dren.mil FU U.S. Army Engineer Research and Development Center, Basic Research Program Office FX This work was funded through the U.S. Army Engineer Research and Development Center, Basic Research Program Office. Permission for publishing this information has been granted by the Chief of Engineers. NR 39 TC 1 Z9 1 U1 1 U2 1 PU JOURNAL OF VISUALIZED EXPERIMENTS PI CAMBRIDGE PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA SN 1940-087X J9 JOVE-J VIS EXP JI J. Vis. Exp. PD JUL PY 2016 IS 113 AR e54091 DI 10.3791/54091 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DZ1TG UT WOS:000385622600035 ER PT J AU Wentz, LM Berry-Caban, CS Wu, Q Eldred, JD AF Wentz, L. M. Berry-Caban, C. S. Wu, Q. Eldred, J. D. TI Vitamin D Correlation with Testosterone Concentration in Male US Soldiers and Veterans SO JOURNAL OF MILITARY AND VETERANS HEALTH LA English DT Article DE 25-hydroxyvitamin D; androgen; endocrine hormones; human performance; militarymay ID CLINICAL-PRACTICE GUIDELINE; D DEFICIENCY; ASSOCIATION; MEN; HYPOGONADISM; POPULATION; FEMALE AB Background: Vitamin D has been positively correlated with testosterone in older men, but these hormonal relationships have not been examined in military personnel. Purpose: The purpose of this study was to identify significant correlations between vitamin D and testosterone concentrations in male soldiers and veterans. Material and Methods: This study examined unique cases of serum vitamin D assessments ordered at Womack Army Medical Center, Fort Bragg, NC, from January 2012 - September 2013. Inclusion criteria were male soldiers or veterans who had a testosterone assessment within 21 days of vitamin D assessment, yielding 796 subjects. General linear models were used to test the effect of vitamin D on total testosterone. Results: Mean serum vitamin D concentrations were 29.2 +/- 11.1 ng/ml, with 55.7% of subjects in the deficient or insufficient range of <30 ng/ml according to the US Army Medical Department guidelines. Mean total testosterone concentrations were 426.9 +/- 178.6 ng/dl. Subjects in the lowest vitamin D quintile had significantly lower testosterone concentrations, younger age, and higher BMI than subjects in the highest quintile. When BMI, age, and time of testosterone measurement were included in the model to predict testosterone concentrations, the significance of vitamin D was eliminated. Conclusion: These data show a high prevalence of vitamin D deficiency in male soldiers and veterans assessed in the southeast region of the United States. Since vitamin D deficiency may be related to hypothalamopituitary dysfunction in service members, future research should prospectively assess vitamin D status in comprehensive treatment plans for endocrine disorders C1 [Wentz, L. M.] East Carolina Univ, Dept Nutr Sci, Greenville, NC 27858 USA. [Berry-Caban, C. S.] Womack Army Med Ctr, Dept Clin Invest, Ft Bragg, NC USA. [Wu, Q.] East Carolina Univ, Dept Biostat, Greenville, NC 27858 USA. [Eldred, J. D.] Univ New Mexico, Sch Med, Albuquerque, NM 87131 USA. RP Wentz, LM (reprint author), East Carolina Univ, Dept Nutr Sci, Greenville, NC 27858 USA. EM wentzl@ecu.edu NR 27 TC 0 Z9 0 U1 1 U2 1 PU AUSTRALASIAN MILITARY MEDICINE ASSOC PI HOBART PA AMMA SECRETARIAT, 113 HARRINGTON ST, HOBART, TAS 7000, AUSTRALIA SN 1835-1271 EI 1839-2733 J9 J MIL VETERANS HEALT JI J. Mil. Veterans Health PD JUL PY 2016 VL 24 IS 3 BP 17 EP 23 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA DY1YO UT WOS:000384890500003 ER PT J AU Marble, S AF Marble, Sanders TI Joint Expeditionary Medical Support in 1914: The US Occupation of Veracruz, Mexico SO JOURNAL OF MILITARY AND VETERANS HEALTH LA English DT Article DE Military Medicine/history; Military Medicine/organisation & administration; Preventive Medicine/history C1 [Marble, Sanders] US Army, Off Med Hist, New York, NY 96208 USA. RP Marble, S (reprint author), US Army, Off Med Hist, New York, NY 96208 USA. EM william.s.marble.civ@mail.mil NR 22 TC 0 Z9 0 U1 1 U2 1 PU AUSTRALASIAN MILITARY MEDICINE ASSOC PI HOBART PA AMMA SECRETARIAT, 113 HARRINGTON ST, HOBART, TAS 7000, AUSTRALIA SN 1835-1271 EI 1839-2733 J9 J MIL VETERANS HEALT JI J. Mil. Veterans Health PD JUL PY 2016 VL 24 IS 3 BP 28 EP 33 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA DY1YO UT WOS:000384890500005 ER PT J AU Choi, YT Robinson, R Hu, W Wereley, NM Birchette, TS Bolukbasi, AO Woodhouse, J AF Choi, Young-Tai Robinson, Ryan Hu, Wei Wereley, Norman M. Birchette, Terrence S. Bolukbasi, Akif O. Woodhouse, Jin TI Analysis and Control of a Magnetorheological Landing Gear System for a Helicopter SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article ID VIBRATION; VALIDATION; DAMPER AB This study develops the design analysis and control of adaptive magnetorheological landing gear dampers (MRLGDs) to enable adaptive shock mitigation in a lightweight helicopter. MRLGDs were designed to achieve a desired stroking load of 4000 lb (17.8 kN) over a desired equivalent sink rate range of 6-12 ft/s (1.83-3.65 m/s). The design analysis at low equivalent sink rates, v(s) < 10 ft/s (3.05 m/s), was experimentally validated using ramp displacement inputs on a servo-hydraulic testing machine at low speed. To validate the analysis at high equivalent sink rates, v(s) > 10 ft/s (3.05 m/s), single damper drop tests were performed. Two force feedback control algorithms were developed to achieve the desired constant stroking load over the desired sink rate range, that is, (1) bang-bang current control and (2) continuous current control. The effectiveness of control algorithms was evaluated using both single damper drop tests and an iron-bird test setup with a landing gear system having a pair of forward and aft MRLGDs. C1 [Choi, Young-Tai; Robinson, Ryan; Hu, Wei; Wereley, Norman M.] Univ Maryland, Dept Aerosp Engn, College Pk, MD 20742 USA. [Birchette, Terrence S.; Bolukbasi, Akif O.] Boeing Co, Mesa, AZ USA. [Woodhouse, Jin] US Army, Aviat Dev Directorate, Aviat Appl Technol Directorate, Ft Eustis, VA USA. RP Wereley, NM (reprint author), Univ Maryland, Dept Aerosp Engn, College Pk, MD 20742 USA. EM Wereley@umd.edu NR 14 TC 1 Z9 1 U1 1 U2 1 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 EI 2161-6027 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD JUL PY 2016 VL 61 IS 3 AR 032006 DI 10.4050/JAHS.61.032006 PG 8 WC Engineering, Aerospace SC Engineering GA DY3NG UT WOS:000384999900006 ER PT J AU Yeo, H Jain, R Jayaraman, B AF Yeo, Hyeonsoo Jain, Rohit Jayaraman, Buvana TI Investigation of Rotor Vibratory Loads of a UH-60A Individual Blade Control System SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article ID HELICOPTER; PREDICTION; AIRLOADS; DYNAMICS AB Wind tunnel measurements of a full-scale UH-60A Black Hawk main rotor with an individual blade control (IBC) system are compared with calculations obtained using a Rotorcraft Comprehensive Analysis System (RCAS) and a coupled computational fluid dynamics/computational structural dynamics (CFD/CSD) analysis using Helios. The effects of open-loop 3, 4, and 5/rev IBC on vibratory hub loads, rotor performance, and IBC actuator loads (pitch link loads) are investigated at high-speed, moderate-thrust and high-thrust, moderate-speed conditions. RCAS captures maximum vibratory hub load reduction values well for some cases, but phase is generally not well captured at all. The coupled analysis shows reasonably good correlation with the measured vibratory hub load variations with 3/rev IBC actuation at the high-speed condition. However, the vibratory hub load correlation is worse for 4 and 5/rev IBC actuations. IBC actuations also have a significant influence on rotor performance. Measured data show a maximum 2.2% rotor power reduction (3.9% increase in rotor lift to effective-drag ratio) using 3/rev IBC actuation with 0.9 degrees. amplitude at mu = 0.35. In general, the coupled analysis shows good correlation with the measured rotor power variations at both high-speed and high-thrust conditions. Half peak-to-peak IBC actuator load variations are well predicted by the coupled analysis only for the 3/rev IBC actuation at high speed. In general, correlation at the high-speed condition is better than for the high-thrust condition. C1 [Yeo, Hyeonsoo; Jain, Rohit] US Army, Aviat Dev Directorate AFDD, Aviat & Missile Res Dev & Engn Ctr, Res Dev & Engn Command,Ames Res Ctr, Moffett Field, CA 94035 USA. [Jayaraman, Buvana] Sci & Technol Corp, Ames Res Ctr, Moffett Field, CA USA. RP Yeo, H (reprint author), US Army, Aviat Dev Directorate AFDD, Aviat & Missile Res Dev & Engn Ctr, Res Dev & Engn Command,Ames Res Ctr, Moffett Field, CA 94035 USA. EM hyeonsoo.yeo.civ@mail.mil NR 41 TC 0 Z9 0 U1 0 U2 0 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 EI 2161-6027 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD JUL PY 2016 VL 61 IS 3 AR 032009 DI 10.4050/JAHS.61.032009 PG 16 WC Engineering, Aerospace SC Engineering GA DY3NG UT WOS:000384999900009 ER PT J AU Ghoreyshi, M Bergeron, K Seidel, J Lofthouse, AJ Cummings, RM AF Ghoreyshi, Mehdi Bergeron, Keith Seidel, Juergen Lofthouse, Andrew J. Cummings, Russell M. TI Grid Quality and Resolution Effects for Aerodynamic Modeling of Ram-Air Parachutes SO JOURNAL OF AIRCRAFT LA English DT Article; Proceedings Paper CT 53rd AIAA Aerospace Sciences Meeting / AIAA Atmospheric Flight Mechanics Conference / 17th AIAA Non-Deterministic Approaches Conference / AIAA Science and Technology Forum and Exposition (SciTech) / AIAA Infotech at Aerospace Conference CY JAN 05-09, 2015 CL Kissimmee, FL SP AIAA AB This work provides an overview of the grid quality and resolution effects on the aerodynamic modeling of ram-air parachute canopies. The computational-fluid-dynamics simulations of this work were performed using the Cobalt flow solver, which is a three-dimensional code, but it was run in a two-dimensional mode for canopy sections with open and closed inlets. Previous simulation results of these geometries showed that grid independence is achieved for the closed and open airfoils with grids containing around half a million and 2 million cells, respectively. Previous grids were either hybrid with prismatic layers near the walls or multiblock structured using algebraic grid generators. The results presented in this work show that grid independence of both geometries can be achieved with much coarser grids. These grids, however, were generated with good smoothness, wall orthogonality, and skewness qualities. The results show that the grid quality value is mainly related to the grid smoothness and does not depend on the grid skewness or the wall orthogonality. Although a smooth grid improves the quality value, and therefore the solution convergence, it does not always lead to an accurate solution. For example, the unstructured grids with anisotropic cells near the wall have very good grid quality; however, they have the worst accuracy among all grids considered because of the poor skewness at the walls. The results also showed that, in comparison to the closed inlets, the open geometry solutions are less sensitive to the initial grid spacing and number of constant spacing layers at the outside airfoil walls. Finally, the open inlet solutions do not change with the inside airfoil grid resolution and type. C1 [Ghoreyshi, Mehdi; Seidel, Juergen; Lofthouse, Andrew J.; Cummings, Russell M.] US Air Force Acad, High Performance Comp Res Ctr, Colorado Springs, CO 80840 USA. [Bergeron, Keith] US Army, Natick Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Ghoreyshi, M (reprint author), US Air Force Acad, High Performance Comp Res Ctr, Colorado Springs, CO 80840 USA. NR 42 TC 0 Z9 0 U1 0 U2 0 PU AMER INST AERONAUTICS ASTRONAUTICS PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0021-8669 EI 1533-3868 J9 J AIRCRAFT JI J. Aircr. PD JUL-AUG PY 2016 VL 53 IS 4 BP 1087 EP 1105 DI 10.2514/1.C033391 PG 19 WC Engineering, Aerospace SC Engineering GA DX3TN UT WOS:000384297100020 ER PT J AU Smith, R AF Smith, Roger TI The Modern Art of Innovation SO RESEARCH-TECHNOLOGY MANAGEMENT LA English DT Editorial Material C1 [Smith, Roger] Florida Hosp, Nicholson Ctr Surg Adv, Orlando, FL 32803 USA. [Smith, Roger] US Army Simulat, CTO, Orlando, FL USA. [Smith, Roger] Titan Corp, San Diego, CA USA. [Smith, Roger] BTG Inc, Jacksonville, FL USA. RP Smith, R (reprint author), Florida Hosp, Nicholson Ctr Surg Adv, Orlando, FL 32803 USA. EM roger.smith@flhosp.org NR 0 TC 0 Z9 0 U1 0 U2 0 PU INDUSTRIAL RESEARCH INST, INC PI ARLINGTON PA 2300 CLARENDON BLVD, STE 400, ARLINGTON, VA 22201 USA SN 0895-6308 EI 1930-0166 J9 RES TECHNOL MANAGE JI Res.-Technol. Manage. PD JUL-AUG PY 2016 VL 59 IS 4 BP 59 EP 60 DI 10.1080/08956308.2016.1185345 PG 2 WC Business; Engineering, Industrial; Management SC Business & Economics; Engineering GA DX6ZL UT WOS:000384535000011 ER PT J AU Christesen, SD Guicheteau, JA Curtiss, JM Fountain, AW AF Christesen, Steven D. Guicheteau, Jason A. Curtiss, Justin M. Fountain, Augustus W., III TI Handheld dual-wavelength Raman instrument for the detection of chemical agents and explosives SO OPTICAL ENGINEERING LA English DT Article DE dual-wavelength Raman; Raman; chemical agents; explosives ID SPECTROSCOPY AB Handheld Raman systems have become powerful analytical tools for the detection and identification of hazardous chemical materials that are now commonly used by both the civilian and military communities. Due to the availability of compact lasers and sensitive detectors, systems typically operate at 785 nm. However, the Raman return at this wavelength can still be obscured by fluorescent impurities in the targeted materials or their matrices. To potentially mitigate this shortcoming, a prototype dual-wavelength Raman incorporating both 785- and 1064-nm excitations was developed and assessed at the Edgewood Chemical Biological Center. The results of that evaluation are discussed here. (C) 2016 Society of Photo-Optical Instrumentation Engineers (SPIE) C1 [Christesen, Steven D.; Guicheteau, Jason A.; Fountain, Augustus W., III] US Army, Edgewood Chem Biol Ctr, APG EA, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. [Curtiss, Justin M.] Excet Inc, 6225 Brandon Ave,Suite 360, Springfield, VA 22151 USA. RP Christesen, SD (reprint author), US Army, Edgewood Chem Biol Ctr, APG EA, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM steven.d.christesen.civ@mail.mil FU U.S. Army under the Army Technology Objective "Detection of Unknown Bulk Explosives" [R.FP.2010.01]; Army Small Business Innovation Research [W911SR-10-C-0053]; Aerius Photonics, Ventura, California FX This research was funded by the U.S. Army under the Army Technology Objective R.FP.2010.01 "Detection of Unknown Bulk Explosives" and through an Army Small Business Innovation Research Contract No. W911SR-10-C-0053 with Aerius Photonics, Ventura, California. The opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the United States Government. This document is approved for public release. NR 22 TC 0 Z9 0 U1 8 U2 8 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 EI 1560-2303 J9 OPT ENG JI Opt. Eng. PD JUL PY 2016 VL 55 IS 7 AR 074103 DI 10.1117/1.OE.55.7.074103 PG 6 WC Optics SC Optics GA DV9IN UT WOS:000383254200015 ER PT J AU Muir, R Metcalf, T Tardif, V Takata, H Phanuphak, N Kroon, E Colby, DJ Trichavaroj, R Valcour, V Robb, ML Michael, NL Ananworanich, J Trautmann, L Haddad, EK AF Muir, Roshell Metcalf, Talibah Tardif, Virginie Takata, Hiroshi Phanuphak, Nittaya Kroon, Eugene Colby, Donn J. Trichavaroj, Rapee Valcour, Victor Robb, Merlin L. Michael, Nelson L. Ananworanich, Jintanat Trautmann, Lydie Haddad, Elias K. CA RV254 Study Grp SEARCH010 RV304 Grp SEARCH 013 Study Grp TI Altered Memory Circulating T Follicular Helper-B Cell Interaction in Early Acute HIV Infection SO PLOS PATHOGENS LA English DT Article ID IMMUNODEFICIENCY-VIRUS-INFECTION; ANTIRETROVIRAL THERAPY; ANTIBODY-RESPONSES; HUMORAL IMMUNITY; TFH CELLS; DISEASE; IL-10; INDIVIDUALS; GENERATION; INITIATION AB The RV254 cohort of HIV-infected very early acute (4thG stage 1 and 2) (stage 1/2) and late acute (4thG stage 3) (stage 3) individuals was used to study T helper-B cell responses in acute HIV infection and the impact of early antiretroviral treatment (ART) on T and B cell function. To investigate this, the function of circulating T follicular helper cells (cTfh) from this cohort was examined, and cTfh and memory B cell populations were phenotyped. Impaired cTfh cell function was observed in individuals treated in stage 3 when compared to stage 1/2. The cTfh/B cell cocultures showed lower B cell survival and IgG secretion at stage 3 compared to stage 1/2. This coincided with lower IL-10 and increased RANTES and TNF-alpha suggesting a role for inflammation in altering cTfh and B cell responses. Elevated plasma viral load in stage 3 was found to correlate with decreased cTfh-mediated B cell IgG production indicating a role for increased viremia in cTfh impairment and dysfunctional humoral response. Phenotypic perturbations were also evident in the mature B cell compartment, most notably a decrease in resting memory B cells in stage 3 compared to stage 1/2, coinciding with higher viremia. Our coculture assay also suggested that intrinsic memory B cell defects could contribute to the impaired response despite at a lower level. Overall, cTfh-mediated B cell responses are significantly altered in stage 3 compared to stage 1/2, coinciding with increased inflammation and a reduction in memory B cells. These data suggest that early ART for acutely HIV infected individuals could prevent immune dysregulation while preserving cTfh function and B cell memory. C1 [Muir, Roshell; Metcalf, Talibah; Tardif, Virginie; Haddad, Elias K.] Drexel Univ, Dept Med, Div Infect Dis & HIV Med, Philadelphia, PA 19104 USA. [Takata, Hiroshi; Robb, Merlin L.; Ananworanich, Jintanat; Trautmann, Lydie] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Takata, Hiroshi; Robb, Merlin L.; Michael, Nelson L.; Ananworanich, Jintanat; Trautmann, Lydie] US Mil HIV Res Program, Bethesda, MD USA. [Phanuphak, Nittaya; Kroon, Eugene; Colby, Donn J.; Ananworanich, Jintanat] Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, Thailand. [Trichavaroj, Rapee] US Component, Dept Retrovirol, Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Valcour, Victor] Univ Calif San Francisco, Memory & Aging Ctr, San Francisco, CA 94143 USA. RP Haddad, EK (reprint author), Drexel Univ, Dept Med, Div Infect Dis & HIV Med, Philadelphia, PA 19104 USA. EM elias.elhaddad@drexelmed.edu FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc [W81XWH-07-2-0067]; U.S. Department of Defense (DoD) [W81XWH-07-2-0067]; Government Pharmaceutical Organization, Thailand; ViiV Healthcare; Gilead; Merck; National Institutes of Health [1R01AI106482-01A1, 1R01AI108433-01A1] FX This work is supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, and the U.S. Department of Defense (DoD). Antiretroviral therapy was supported by Government Pharmaceutical Organization, Thailand, ViiV Healthcare, Gilead and Merck. All assay experiments were funded by a National Institutes of Health grant to EKH 1R01AI106482-01A1 and by a National Institutes of Health grant to LT 1R01AI108433-01A1. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 49 TC 4 Z9 4 U1 0 U2 0 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-7366 EI 1553-7374 J9 PLOS PATHOG JI PLoS Pathog. PD JUL PY 2016 VL 12 IS 7 AR e1005777 DI 10.1371/journal.ppat.1005777 PG 17 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA DW0XN UT WOS:000383366400049 PM 27463374 ER PT J AU Rademeyer, C Korber, B Seaman, MS Giorgi, EE Thebus, R Robles, A Sheward, DJ Wagh, K Garrity, J Carey, BR Gao, HM Greene, KM Tang, HL Bandawe, GP Marais, JC Diphoko, TE Hraber, P Tumba, N Moore, PL Gray, GE Kublin, J McElrath, MJ Vermeulen, M Middelkoop, K Bekker, LG Hoelscher, M Maboko, L Makhema, J Robb, ML Karim, SA Karim, QA Kim, JH Hahn, BH Gao, F Swanstrom, R Morris, L Montefiori, DC Williamson, C AF Rademeyer, Cecilia Korber, Bette Seaman, Michael S. Giorgi, Elena E. Thebus, Ruwayhida Robles, Alexander Sheward, Daniel J. Wagh, Kshitij Garrity, Jetta Carey, Brittany R. Gao, Hongmei Greene, Kelli M. Tang, Haili Bandawe, Gama P. Marais, Jinny C. Diphoko, Thabo E. Hraber, Peter Tumba, Nancy Moore, Penny L. Gray, Glenda E. Kublin, James McElrath, M. Juliana Vermeulen, Marion Middelkoop, Keren Bekker, Linda-Gail Hoelscher, Michael Maboko, Leonard Makhema, Joseph Robb, Merlin L. Karim, Salim Abdool Karim, Quarraisha Abdool Kim, Jerome H. Hahn, Beatrice H. Gao, Feng Swanstrom, Ronald Morris, Lynn Montefiori, David C. Williamson, Carolyn TI Features of Recently Transmitted HIV-1 Clade C Viruses that Impact Antibody Recognition: Implications for Active and Passive Immunization SO PLOS PATHOGENS LA English DT Article ID NEUTRALIZING MONOCLONAL-ANTIBODIES; ENVELOPE GLYCOPROTEIN; GLYCOSYLATION SITES; CORECEPTOR TROPISM; VACCINE EFFICACY; LOOP SEQUENCES; ENV CLONES; SUBTYPE-B; TYPE-1; INFECTION AB The development of biomedical interventions to reduce acquisition of HIV-1 infection remains a global priority, however their potential effectiveness is challenged by very high HIV-1 envelope diversity. Two large prophylactic trials in high incidence, clade C epidemic regions in southern Africa are imminent; passive administration of the monoclonal antibody VRC01, and active immunization with a clade C modified RV144-like vaccines. We have created a large representative panel of C clade viruses to enable assessment of antibody responses to vaccines and natural infection in Southern Africa, and we investigated the genotypic and neutralization properties of recently transmitted clade C viruses to determine how viral diversity impacted antibody recognition. We further explore the implications of these findings for the potential effectiveness of these trials. A panel of 200 HIV-1 Envelope pseudoviruses was constructed from clade C viruses collected within the first 100 days following infection. Viruses collected pre-seroconversion were significantly more resistant to serum neutralization compared to post-seroconversion viruses (p = 0.001). Over 13 years of the study as the epidemic matured, HIV-1 diversified (p = 0.0009) and became more neutralization resistant to monoclonal antibodies VRC01, PG9 and 4E10. When tested at therapeutic levels (10ug/ml), VRC01 only neutralized 80% of viruses in the panel, although it did exhibit potent neutralization activity against sensitive viruses (IC50 titres of 0.42 mu g/ml). The Gp120 amino acid similarity between the clade C panel and candidate C-clade vaccine protein boosts (Ce1086 and TV1) was 77%, which is 8% more distant than between CRF01_ AE viruses and the RV144 CRF01_ AE immunogen. Furthermore, two vaccine signature sites, K169 in V2 and I307 in V3, associated with reduced infection risk in RV144, occurred less frequently in clade C panel viruses than in CRF01_ AE viruses from Thailand. Increased resistance of pre-seroconversion viruses and evidence of antigenic drift highlights the value of using panels of very recently transmitted viruses and suggests that interventions may need to be modified over time to track the changing epidemic. Furthermore, high divergence such as that observed in the older clade C epidemic in southern Africa may impact vaccine efficacy, although the correlates of infection risk are yet to be defined in the clade C setting. Findings from this study of acute/early clade C viruses will aid vaccine development, and enable identification of new broad and potent antibodies to combat the HIV-1 C-clade epidemic in southern Africa. C1 [Rademeyer, Cecilia; Thebus, Ruwayhida; Sheward, Daniel J.; Bandawe, Gama P.; Marais, Jinny C.; Williamson, Carolyn] Univ Cape Town, Div Med Virol, Cape Town, South Africa. [Rademeyer, Cecilia; Thebus, Ruwayhida; Sheward, Daniel J.; Bandawe, Gama P.; Marais, Jinny C.; Williamson, Carolyn] Univ Cape Town, Inst Infect Dis & Mol Med, Cape Town, South Africa. [Rademeyer, Cecilia; Thebus, Ruwayhida; Sheward, Daniel J.; Bandawe, Gama P.; Marais, Jinny C.; Williamson, Carolyn] NHLS, Cape Town, South Africa. [Korber, Bette; Giorgi, Elena E.; Wagh, Kshitij; Hraber, Peter] Los Alamos Natl Lab, Los Alamos, NM USA. [Korber, Bette; Giorgi, Elena E.; Wagh, Kshitij; Hraber, Peter] New Mexico Consortium, Los Alamos, NM USA. [Seaman, Michael S.; Robles, Alexander; Garrity, Jetta; Carey, Brittany R.] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. [Gao, Hongmei; Greene, Kelli M.; Tang, Haili; Gao, Feng; Montefiori, David C.] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA. [Diphoko, Thabo E.; Makhema, Joseph] Botswana Harvard AIDS Inst Partnership, Gaborone, Botswana. [Tumba, Nancy; Moore, Penny L.; Morris, Lynn] NHLS, NICD, Johannesburg, South Africa. [Tumba, Nancy; Moore, Penny L.; Morris, Lynn] Univ Witwatersrand, Johannesburg, South Africa. [Moore, Penny L.; Karim, Salim Abdool; Karim, Quarraisha Abdool; Morris, Lynn; Williamson, Carolyn] Univ KwaZulu Natal, Ctr AIDS Programme Res South Africa CAPRISA, Durban, South Africa. [Gray, Glenda E.] Univ Witwatersrand, Fac Hlth Sci, Perinatal HIV Res Unit, Johannesburg, South Africa. [Gray, Glenda E.] South African Med Res Council, Cape Town, South Africa. [Kublin, James; McElrath, M. Juliana] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, 1124 Columbia St, Seattle, WA 98104 USA. [Vermeulen, Marion] South African Natl Blood Serv, Weltevreden Pk, South Africa. [Middelkoop, Keren; Bekker, Linda-Gail] Univ Cape Town, Desmond Tutu HIV Ctr, Dept Med, Cape Town, South Africa. [Middelkoop, Keren; Bekker, Linda-Gail] Univ Cape Town, Inst Infect Dis & Mol Med, Cape Town, South Africa. [Hoelscher, Michael] LMU, Klinikum Univ Munich, Dept Infect Dis & Trop Med, Munich, Germany. [Hoelscher, Michael] German Ctr Infect Res DZIF Partner Site Munich, Munich, Germany. [Maboko, Leonard] NIMR Mbeya Med Res Ctr, Mbeya, Tanzania. [Robb, Merlin L.; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Kim, Jerome H.] Int Vaccine Inst, Seoul, South Korea. [Hahn, Beatrice H.] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA. [Swanstrom, Ronald] Univ North Carolina Chapel Hill, Dept Biochem & Biophys, Chapel Hill, NC USA. RP Williamson, C (reprint author), Univ Cape Town, Div Med Virol, Cape Town, South Africa.; Williamson, C (reprint author), Univ Cape Town, Inst Infect Dis & Mol Med, Cape Town, South Africa.; Williamson, C (reprint author), NHLS, Cape Town, South Africa.; Williamson, C (reprint author), Univ KwaZulu Natal, Ctr AIDS Programme Res South Africa CAPRISA, Durban, South Africa. EM carolyn.williamson@uct.ac.za RI Hoelscher, Michael/D-3436-2012; OI Abdool Karim, Salim/0000-0002-4986-2133; Hraber, Peter/0000-0002-2920-4897 FU Bill & Melinda Gates Foundation [38619, 1032144]; National Institute of Allergy and infectious Disease (NIAID), National Institutes of Health (NIH) [AI51794]; National Research Foundation [67385]; Columbia University-Southern African Fogarty AIDS International Training and Research Programme (AITRP) - Fogarty International Center, NIH [D43TW00231]; South African Government Department of Science and Technology; Medical Research Council, South Africa FX This study is part of the Comprehensive Antibody Vaccine Immune Monitoring Consortium supported by the Bill & Melinda Gates Foundation which established the Collaboration for AIDS Vaccine Discovery (CAVD) (Grant ID: 38619 and 1032144). CAPRISA samples has been supported by the National Institute of Allergy and infectious Disease (NIAID), National Institutes of Health (NIH) (grant # AI51794), the National Research Foundation (grant # 67385), the Columbia University-Southern African Fogarty AIDS International Training and Research Programme (AITRP) funded by the Fogarty International Center, NIH (grant # D43TW00231) the South African Government Department of Science and Technology and the Medical Research Council, South Africa. The opinions expressed herein are those of the authors and do not purport to reflect the official views of the networks that contributed samples. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 72 TC 2 Z9 2 U1 2 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-7366 EI 1553-7374 J9 PLOS PATHOG JI PLoS Pathog. PD JUL PY 2016 VL 12 IS 7 AR e1005742 DI 10.1371/journal.ppat.1005742 PG 29 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA DW0XN UT WOS:000383366400027 PM 27434311 ER PT J AU Fleischmann, J Serban, R Negrut, D Jayakumar, P AF Fleischmann, Jonathan Serban, Radu Negrut, Dan Jayakumar, Paramsothy TI On the Importance of Displacement History in Soft-Body Contact Models SO JOURNAL OF COMPUTATIONAL AND NONLINEAR DYNAMICS LA English DT Article ID DIRECT MICROMECHANICS DERIVATION; DISCRETE-ELEMENT SIMULATIONS; ELASTIC-MODULI; GRANULAR ASSEMBLIES; PARTICLE ROTATION; DEM CONFIRMATION; FORCE MODELS; DYNAMICS; FRICTION AB Two approaches are commonly used for handling frictional contact within the framework of the discrete element method (DEM). One relies on the complementarity method (CM) to enforce a non-penetration condition and the Coulomb dry-friction model at the interface between two bodies in mutual contact. The second approach, called the penalty method (PM), invokes an elasticity argument to produce a frictional contact force that factors in the local deformation and relative motion of the bodies in contact. We give a brief presentation of a DEM-PM contact model that includes multi-time-step tangential contact displacement history. We show that its implementation in an open-source simulation capability called Chrono is capable of accurately reproducing results from physical tests typical of the field of geomechanics, i.e., direct shear tests on a monodisperse material. Keeping track of the tangential contact displacement history emerges as a key element of the model. We show that identical simulations using contact models that include either no tangential contact displacement history or only single-time-step tangential contact displacement history are unable to accurately model the direct shear test. C1 [Fleischmann, Jonathan; Serban, Radu; Negrut, Dan] Univ Wisconsin, Dept Mech Engn, SBEL, Madison, WI 53706 USA. [Jayakumar, Paramsothy] US Army, TARDEC, Warren, MI 48397 USA. RP Fleischmann, J (reprint author), Univ Wisconsin, Dept Mech Engn, SBEL, Madison, WI 53706 USA. EM jafleisc@wisc.edu; serban@wisc.edu; negrut@wisc.edu; paramsothy.jayakumar.civ@mail.mil FU U.S. Army Rapid Innovation Fund [W911NF-13-R-0011]; National Science Foundation [GOALI-CMMI 1362583] FX This research was supported in part by U.S. Army Rapid Innovation Fund No. W911NF-13-R-0011, Topic No. 6a Maneuverability Prediction, and National Science Foundation Grant No. GOALI-CMMI 1362583. NR 28 TC 0 Z9 0 U1 0 U2 0 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 1555-1423 EI 1555-1415 J9 J COMPUT NONLIN DYN JI J. Comput. Nonlinear Dyn. PD JUL PY 2016 VL 11 IS 4 AR 044502 DI 10.1115/1.4031197 PG 5 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA DV7GF UT WOS:000383103700032 ER PT J AU Olsen, ME Filone, CM Rozelle, D Mire, CE Agans, KN Hensley, L Connor, JH AF Olsen, Michelle E. Filone, Claire Marie Rozelle, Dan Mire, Chad E. Agans, Krystle N. Hensley, Lisa Connor, John H. TI Polyamines and Hypusination Are Required for Ebolavirus Gene Expression and Replication SO MBIO LA English DT Article ID INITIATION-FACTOR 5A; CHLORELLA-VIRUS PBCV-1; NIEMANN-PICK C1; PROMOTES TRANSLATION; RNA SYNTHESIS; AMINO-ACID; INFECTION; DECARBOXYLASE; INHIBITION; CELLS AB Ebolavirus (EBOV) is an RNA virus that is known to cause severe hemorrhagic fever in humans and other primates. EBOV successfully enters and replicates in many cell types. This replication is dependent on the virus successfully coopting a number of cellular factors. Many of these factors are currently unidentified but represent potential targets for antiviral therapeutics. Here we show that cellular polyamines are critical for EBOV replication. We found that small-molecule inhibitors of polyamine synthesis block gene expression driven by the viral RNA-dependent RNA polymerase. Short hairpin RNA (shRNA) knockdown of the polyamine pathway enzyme spermidine synthase also resulted in reduced EBOV replication. These findings led us to further investigate spermidine, a polyamine that is essential for the hypusination of eukaryotic initiation factor 5A (eIF5A). Blocking the hypusination of eIF5A (and thereby inhibiting its function) inhibited both EBOV gene expression and viral replication. The mechanism appears to be due to the importance of hypusinated eIF5A for the accumulation of VP30, an essential component of the viral polymerase. The same reduction in hypusinated eIF5A did not alter the accumulation of other viral polymerase components. This action makes eIF5A function an important gate for proper EBOV polymerase assembly and function through the control of a single virus protein. IMPORTANCE Ebolavirus (EBOV) is one of the most lethal human pathogens known. EBOV requires host factors for replication due to its small RNA genome. Here we show that the host protein eIF5A in its activated form is necessary for EBOV replication. We further show that the mechanism is through the accumulation of a single EBOV protein, VP30. To date, no other host proteins have been shown to interfere with the translation or stability of an EBOV protein. Activated eIF5A is the only protein in the cell known to contain the specific modification of hypusine; therefore, this pathway is a target for drug development. Further investigation into the mechanism of eIF5A interaction with VP30 could provide insight into therapeutics to combat EBOV. C1 [Olsen, Michelle E.; Filone, Claire Marie; Rozelle, Dan; Connor, John H.] Boston Univ, Dept Microbiol, Boston, MA 02215 USA. [Mire, Chad E.; Agans, Krystle N.] Univ Texas Med Branch, Galveston Natl Lab, Galveston, TX 77555 USA. [Hensley, Lisa] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. [Hensley, Lisa] NIAID, Integrated Res Facil, NIH, Ft Detrick, MD USA. [Filone, Claire Marie] Natl Biodef Anal & Countermeasures Ctr, Ft Detrick, MD USA. [Rozelle, Dan] Pfizer Inc, Andover, MA USA. RP Connor, JH (reprint author), Boston Univ, Dept Microbiol, Boston, MA 02215 USA. EM jhconnor@bu.edu OI Connor, John/0000-0002-8867-7256 FU HHS \ National Institutes of Health (NIH) [AI121933, AI1096159-04, UC7-AI094660]; HHS \ NIH \ National Institute of Allergy and Infectious Diseases (NIAID) [UC6AI058618] FX This work, including the efforts of John Connor, Michelle E. Olsen, Claire Marie Filone, and Dan Rozelle, was funded by HHS vertical bar National Institutes of Health (NIH) (AI121933 and AI1096159-04). This work, including the efforts of Chad Mire and Krystle Agans, was funded by HHS vertical bar National Institutes of Health (NIH) (UC7-AI094660). This work, including the efforts of John Connor, Michelle E. Olsen, Claire Marie Filone, and Dan Rozelle, was funded by HHS vertical bar NIH vertical bar National Institute of Allergy and Infectious Diseases (NIAID) (UC6AI058618). NR 36 TC 1 Z9 1 U1 1 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 2150-7511 J9 MBIO JI mBio PD JUL-AUG PY 2016 VL 7 IS 4 AR e00882-16 DI 10.1128/mBio.00882-16 PG 10 WC Microbiology SC Microbiology GA DW1YQ UT WOS:000383440500033 ER PT J AU Biryukov, S Angov, E Landmesser, ME Spring, MD Ockenhouse, CF Stoute, JA AF Biryukov, Sergei Angov, Evelina Landmesser, Mary E. Spring, Michele D. Ockenhouse, Christian F. Stoute, Jose A. TI Complement and Antibody-mediated Enhancement of Red Blood Cell Invasion and Growth of Malaria Parasites SO EBIOMEDICINE LA English DT Article DE Malaria; Complement; Red blood cells; Merozoites; CR1 ID MEROZOITE SURFACE PROTEIN-1; PLASMODIUM-CHABAUDI-CHABAUDI; PROTECTIVE IMMUNITY; MYCOBACTERIUM-TUBERCULOSIS; FALCIPARUM INVASION; PASSIVE TRANSFER; AOTUS-NANCYMAI; C3B RECEPTOR; IN-VITRO; FACTOR-H AB Plasmodium falciparum malaria is a deadly pathogen. The invasion of red blood cells (RBCs) by merozoites is a target for vaccine development. Although anti-merozoite antibodies can block invasion in vitro, there is no efficacy in vivo. To explain this discrepancywe hypothesized that complement activation could enhance RBC invasion by binding to the complement receptor 1 (CR1). Here we show that a monoclonal antibody directed against the merozoite and human polyclonal IgG from merozoite vaccine recipients enhanced RBC invasion in a complement-dependent manner and that soluble CR1 inhibited this enhancement. Sialic acid-independent strains, that presumably are able to bind to CR1 via a native ligand, showed less complement-dependent enhancement of RBC invasion than sialic acid-dependent strains that do not utilize native CR1 ligands. Confocal fluorescent microscopy revealed that complement-dependent invasion resulted in aggregation of CR1 at the RBC surface in contact with the merozoite. Finally, total anti-P. berghei IgG enhanced parasite growth and C3 deficiency decreased parasite growth in mice. These results demonstrate, contrary to current views, that complement activation in conjunction with antibodies can paradoxically aid parasites invade RBCs and should be considered in future design and testing of merozoite vaccines. (C) 2016 The Authors. Published by Elsevier B.V. C1 [Biryukov, Sergei; Landmesser, Mary E.; Stoute, Jose A.] Penn State Univ, Coll Med, Dept Microbiol & Immunol, 500 Univ Dr, Hershey, PA 17033 USA. [Landmesser, Mary E.; Stoute, Jose A.] Penn State Univ, Coll Med, Div Infect Dis & Epidemiol, Dept Med, 500 Univ Dr, Hershey, PA 17033 USA. [Angov, Evelina; Spring, Michele D.] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA. [Ockenhouse, Christian F.] PATH Malaria Vaccine Initiat, Washington, DC 20001 USA. RP Stoute, JA (reprint author), 500 Univ Dr,Rm C6860,MC H036, Hershey, PA 17033 USA. EM jstoute@psu.edu NR 59 TC 3 Z9 3 U1 3 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 2352-3964 J9 EBIOMEDICINE JI EBioMedicine PD JUL PY 2016 VL 9 BP 207 EP 216 DI 10.1016/j.ebiom.2016.05.015 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA DT6VL UT WOS:000381622500032 PM 27333049 ER PT J AU Maliel, KT Furgerson, JL Thomas, DM AF Maliel, Kurian T. Furgerson, James L. Thomas, Dustin M. TI Training in Cardiac CT: a Continuously Evolving Modality SO CURRENT CARDIOVASCULAR IMAGING REPORTS LA English DT Article DE Coronary computed tomography angiography; Graduate medical education; Fellowship training; Maintenance of certification ID CARDIOVASCULAR COMPUTED-TOMOGRAPHY; TASK-FORCE; CERTIFICATION; COMPETENCE; STATEMENT AB Purpose of Review Over the past decade, the field of cardiac computed tomography (CCT) has experienced rapid evolution from an obscure curiosity to a powerful prognostic imaging modality for the evaluation of cardiovascular disease in a wide variety of clinical settings. Coronary CT angiography (CCTA) and coronary artery calcium (CAC) scoring for the diagnosis of coronary artery disease (CAD) in symptomatic and asymptomatic patients, respectively, remains the cornerstone of CCT imaging. Recent Findings In recent years, significant advances have been made in the evaluation of valvular heart disease, ischemic testing, and structural heart disease that require continual updating of any comprehensive CCT training curriculum. This rapid increase in data and potential applications of CCT provides a unique challenge in developing a training curriculum for CCT. Additionally, CCT imagers originate from a myriad of training backgrounds and, thus, may need very different didactic and hands-on training in order to build toward a common goal of CCT competence. Summary In this review, current training statements and guidelines from a variety of sources are reviewed in the context of highlighting the keys to developing and maintaining a comprehensive CCT curriculum in the current era. C1 [Maliel, Kurian T.; Furgerson, James L.; Thomas, Dustin M.] Brooke Army Med Ctr, Div Cardiol, San Antonio, TX 78234 USA. RP Thomas, DM (reprint author), Brooke Army Med Ctr, Div Cardiol, San Antonio, TX 78234 USA. EM dustin.m.thomas4.mil@mail.mil NR 7 TC 2 Z9 2 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1941-9066 EI 1941-9074 J9 CURR CARDIOVASC IMAG JI CURR. CARDIOVASC. IMAGING REP. PD JUL PY 2016 VL 9 IS 7 AR 20 DI 10.1007/s12410-016-9382-0 PG 7 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA DU5LJ UT WOS:000382252900002 ER PT J AU Bhagwandin, VA AF Bhagwandin, Vishal A. TI High-Alpha Prediction of Roll Damping and Magnus Stability Coefficients for Finned Projectiles SO JOURNAL OF SPACECRAFT AND ROCKETS LA English DT Article; Proceedings Paper CT 30th AIAA Applied Aerodynamics Conference CY JUN 20-28, 2012 CL New Orleans, LA SP AIAA ID GENERALIZED FORMULATION; BODIES; MOTION; MODEL AB The roll damping and Magnus dynamic stability coefficients, as well as total force and moment coefficients, were numerically computed at high angles of attack up to 90deg for two generic fin-stabilized flight munitions at a supersonic Mach number of 2.49. The aerodynamic coefficients were computed via time-accurate Reynolds-averaged Navier-Stokes numerical methods, and they were compared with archival wind-tunnel data. Fair to excellent comparisons with the experiment were obtained for the coefficients for the full angle-of-attack range, except for the axial force, which was overpredicted at higher angles of attack. Numerical modeling parameter studies were conducted to include dependence on spin rate, grid resolution, temporal resolution, and other numerical convergence parameters. C1 [Bhagwandin, Vishal A.] US Army, Res Lab, Flight Sci Branch, WMRD, Aberdeen Proving Ground, MD 21005 USA. [Bhagwandin, Vishal A.] AIAA, Reston, VA 20191 USA. RP Bhagwandin, VA (reprint author), US Army, Res Lab, Flight Sci Branch, WMRD, Aberdeen Proving Ground, MD 21005 USA.; Bhagwandin, VA (reprint author), AIAA, Reston, VA 20191 USA. NR 20 TC 0 Z9 0 U1 0 U2 0 PU AMER INST AERONAUTICS ASTRONAUTICS PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0022-4650 EI 1533-6794 J9 J SPACECRAFT ROCKETS JI J. Spacecr. Rockets PD JUL PY 2016 VL 53 IS 4 BP 720 EP 729 DI 10.2514/1.A33419 PG 10 WC Engineering, Aerospace SC Engineering GA DV1HA UT WOS:000382670500012 ER PT J AU Flick, D AF Flick, David TI Bedside Ultrasound Education in Primary Care SO JOURNAL OF ULTRASOUND IN MEDICINE LA English DT Editorial Material ID RESIDENTS C1 [Flick, David] Tripler Army Med Ctr, Dept Family Med, 1 Jarrett White Rd, Honolulu, HI 96859 USA. RP Flick, D (reprint author), Tripler Army Med Ctr, Dept Family Med, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM dflickmd@gmail.com NR 12 TC 0 Z9 0 U1 0 U2 0 PU AMER INST ULTRASOUND MEDICINE PI LAUREL PA SUBSCRIPTION DEPT, 14750 SWEITZER LANE, STE 100, LAUREL, MD 20707-5906 USA SN 0278-4297 EI 1550-9613 J9 J ULTRAS MED JI J. Ultrasound Med. PD JUL 1 PY 2016 VL 35 IS 7 BP 1369 EP 1371 DI 10.7863/ultra.15.08073 PG 3 WC Acoustics; Radiology, Nuclear Medicine & Medical Imaging SC Acoustics; Radiology, Nuclear Medicine & Medical Imaging GA DU8ZK UT WOS:000382505500001 PM 27208203 ER PT J AU Person, R Landry, PF AF Person, Robert Landry, Pierre F. TI The Political Consequences of Economic Shocks: Implications for Political Behavior in Russia SO PROBLEMS OF POST-COMMUNISM LA English DT Article ID PARTICIPATION; SOCIALIZATION; GENERATIONS; MOVEMENT; ELECTION; PROTESTS; TRENDS AB This paper evaluates long-term political consequences of severe economic shocks by combining a nationally-representative survey of Russians' political behaviors with long-term subnational economic data tracing Russia's post-Soviet economic transition. We show that the shock of transition has durably activated a limited but important sub-population of Russians while deactivating others. Surprisingly, much of the variation in contemporary political participation across Russia's population can be explained by local economic conditions experienced by Russians in the early 1990s: Durable patterns of participation seem to have been "locked in" by economic trauma early in the transition period and are not influenced by the subsequent post-Soviet economic recovery or contemporary economic conditions. C1 [Person, Robert] US Mil Acad, Dept Social Sci, 607 Cullum Rd, West Point, NY 10996 USA. [Landry, Pierre F.] NYU, Dept Polit Sci, Shanghai, Peoples R China. RP Person, R (reprint author), US Mil Acad, Dept Social Sci, 607 Cullum Rd, West Point, NY 10996 USA. EM robert.person@usma.edu FU Yale MacMillan Center for International and Area Studies FX We are grateful to the Yale MacMillan Center for International and Area Studies for their support of this research. NR 66 TC 0 Z9 0 U1 1 U2 1 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1075-8216 EI 1557-783X J9 PROBL POST-COMMUNISM JI Probl. Post-Communism PD JUL-AUG PY 2016 VL 63 IS 4 SI SI BP 221 EP 240 DI 10.1080/10758216.2016.1138846 PG 20 WC Political Science SC Government & Law GA DT6EI UT WOS:000381575900003 ER PT J AU Dunkin, L Reif, M Altman, S Swannack, T AF Dunkin, Lauren Reif, Molly Altman, Safra Swannack, Todd TI A Spatially Explicit, Multi-Criteria Decision Support Model for Loggerhead Sea Turtle Nesting Habitat Suitability: A Remote Sensing-Based Approach SO REMOTE SENSING LA English DT Article DE LIDAR; sea turtle; morphology; nesting habitat; remote sensing ID INDEX MODELS; SITE SELECTION; RESTORATION; LIDAR; LANDSCAPE; FLORIDA AB Nesting habitat for the federally endangered loggerhead sea turtle (Caretta caretta) were designated as critical in 2014 for beaches along the Atlantic Coast and Gulf of Mexico. Nesting suitability is routinely determined based on site specific information. Given the expansive geographic location of the designated critical C. caretta nesting habitat and the highly dynamic coastal environment, understanding nesting suitability on a regional scale is essential for monitoring the changing status of the coast as a result of hydrodynamic forces and maintenance efforts. The increasing spatial resolution and temporal frequency of remote sensing data offers the opportunity to study this dynamic environment on a regional scale. Remote sensing data were used as input into the spatially-explicit, multi-criteria decision support model to determine nesting habitat suitability. Results from the study indicate that the morphological parameters used as input into the model are well suited to provide a regional level approach with the results from the optimized model having sensitivity and detection prevalence values greater than 80% and the detection rate being greater than 70%. The approach can be implemented in various geographic locations to better communicate priorities and evaluate management strategies as a result of changes to the dynamic coastal environment. C1 [Dunkin, Lauren; Altman, Safra; Swannack, Todd] US Army Engn Res & Dev Ctr, 3903 Halls Ferry Rd, Vicksburg, MS 39180 USA. [Reif, Molly] US Army Res & Dev Ctr, Joint Airborne Lidar Bathymetry Tech Ctr Expertis, 7225 Stennis Airport Rd,Suite 100, Kiln, MS 39556 USA. RP Dunkin, L (reprint author), US Army Engn Res & Dev Ctr, 3903 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM lauren.m.dunkin@usace.army.mil; molly.k.reif@usace.army.mil; safra.altman@usace.army.mil; todd.m.swannack@usace.army.mil OI Reif, Molly/0000-0003-4207-1459 NR 44 TC 1 Z9 1 U1 19 U2 19 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 2072-4292 J9 REMOTE SENS-BASEL JI Remote Sens. PD JUL PY 2016 VL 8 IS 7 AR 573 DI 10.3390/rs8070573 PG 22 WC Remote Sensing SC Remote Sensing GA DU5AR UT WOS:000382224800043 ER PT J AU Hauck, BC Siems, WF Harden, CS McHugh, VM Hill, HH AF Hauck, Brian C. Siems, William F. Harden, Charles S. McHugh, Vincent M. Hill, Herbert H., Jr. TI E/N effects on K-0 values revealed by high precision measurements under low field conditions SO REVIEW OF SCIENTIFIC INSTRUMENTS LA English DT Article ID ION MOBILITY SPECTROMETRY; CHEMICAL WARFARE AGENTS; EXPLOSIVES AB Ion mobility spectrometry (IMS) is used to detect chemical warfare agents, explosives, and narcotics. While IMS has a low rate of false positives, their occurrence causes the loss of time and money as the alarm is verified. Because numerous variables affect the reduced mobility (K-0) of an ion, wide detection windows are required in order to ensure a low false negative response rate. Wide detection windows, however, reduce response selectivity, and interferents with similar K-0 values may be mistaken for targeted compounds and trigger a false positive alarm. Detection windows could be narrowed if reference K-0 values were accurately known for specific instrumental conditions. Unfortunately, there is a lack of confidence in the literature values due to discrepancies in the reported K-0 values and their lack of reported error. This creates the need for the accurate control and measurement of each variable affecting ion mobility, as well as for a central accurate IMS database for reference and calibration. A new ion mobility spectrometer has been built that reduces the error of measurements affecting K-0 by an order of magnitude less than +/- 0.2%. Precise measurements of +/- 0.002 cm(2) V-1 s(-1) or better have been produced and, as a result, an unexpected relationship between K-0 and the electric field to number density ratio (E/N) has been discovered in which the K-0 values of ions decreased as a function of E/N along a second degree polynomial trend line towards an apparent asymptote at approximately 4 Td. Published by AIP Publishing. C1 [Hauck, Brian C.; Siems, William F.; Hill, Herbert H., Jr.] Washington State Univ, Dept Chem, 305 Fulmer Hall, Pullman, WA 99164 USA. [Harden, Charles S.] US Army ECBC Operat, LEIDOS, POB 68, Gunpowder, MD 21010 USA. [McHugh, Vincent M.] US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Hill, HH (reprint author), Washington State Univ, Dept Chem, 305 Fulmer Hall, Pullman, WA 99164 USA. EM hhhill@wsu.edu FU LEIDOS; U.S. Army Edgewood Chemical Biological Center; U.S. Army Research Office FX This work was supported in part by LEIDOS as a subcontract under a Task Order contract with the U.S. Army Edgewood Chemical Biological Center and by the U.S. Army Research Office. The expertise, hard work, and advice of Dave Savage, Lauren Frei, Steve Watson, and Fred Schutze of Washington State University's Technical Services Instrument and Electronics shops were invaluable in completing the construction of the IMS instrument and its components. NR 18 TC 1 Z9 1 U1 2 U2 2 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0034-6748 EI 1089-7623 J9 REV SCI INSTRUM JI Rev. Sci. Instrum. PD JUL PY 2016 VL 87 IS 7 AR 075104 DI 10.1063/1.4955208 PG 9 WC Instruments & Instrumentation; Physics, Applied SC Instruments & Instrumentation; Physics GA DU8FL UT WOS:000382448600054 PM 27475592 ER PT J AU Ostashev, VE Wilson, DK Collier, SL Cain, JE Cheinet, S AF Ostashev, Vladimir E. Wilson, D. Keith Collier, Sandra L. Cain, Jericho E. Cheinet, Sylvain TI Cross-frequency coherence and pulse propagation in a turbulent atmosphere SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID RANDOM-MEDIA; LAYER AB Cross-frequency coherence of acoustic signals in a turbulent atmosphere is an important consideration for source localization with acoustic sensor arrays and for remote sensing of the atmosphere with sodars and tomography techniques. This paper takes as a starting point recently derived, closed-form equations for the spatial-temporal correlation function of a broadband acoustic signal propagating in a turbulent atmosphere with coupled spatial-temporal fluctuations in temperature and wind velocity. This theory is employed to calculate, based on the Rytov approximation, the two-point, two-time, two-frequency mutual coherence function of plane and spherical waves in the weak scattering regime. The cross-frequency coherence for these waveforms is then obtained and compared with that in the geometrical acoustics approximation. The coherence bandwidth is calculated and analyzed for typical meteorological regimes of the atmospheric surface layer and parameters of sound propagation. The results obtained are compared with available experimental data. The cross-frequency coherence is also used to study the effect of atmospheric turbulence on the mean intensity of an acoustic pulse propagating in a turbulent atmosphere. C1 [Ostashev, Vladimir E.; Wilson, D. Keith] US Army Engn Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03755 USA. [Collier, Sandra L.; Cain, Jericho E.] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Cheinet, Sylvain] French German Res Inst St Louis ISL, 5 Rue Gen Cassagnou, F-68300 St Louis, France. RP Ostashev, VE (reprint author), US Army Engn Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03755 USA. EM vladimir.ostashev@noaa.gov RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 FU U.S. Army Engineer Research and Development Center, Geospatial Research and Engineering business area; U.S. Army Research Laboratory FX This research was sponsored by the U.S. Army Engineer Research and Development Center, Geospatial Research and Engineering business area. Permission to publish was granted by Director, Cold Regions Research and Engineering Laboratory. The research was also supported in part by an appointment to the Postdoctoral Fellowship Program at the U.S. Army Research Laboratory administered by ORAU and facilitated by the NATO SET-189 Task Group on Battlefield Acoustics, Multi-Modal Sensing, and Networked Sensing for ISR Applications. NR 16 TC 0 Z9 0 U1 2 U2 2 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 EI 1520-8524 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD JUL PY 2016 VL 140 IS 1 BP 678 EP 691 DI 10.1121/1.4959003 PG 14 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA DU7PG UT WOS:000382406500085 PM 27475189 ER PT J AU Uwaydah, NI Hoskins, SL Bruttig, SP Farrar, H Copper, NC Deyo, DJ Dubick, MA Kramer, GC AF Uwaydah, Nabeel I. Hoskins, Stephen L. Bruttig, Stephen P. Farrar, Henry Copper, Nick C. Deyo, Donald J. Dubick, Michael A. Kramer, George C. TI Intramuscular versus Intraosseous Delivery of Nerve Agent Antidote Pralidoxime Chloride in Swine SO PREHOSPITAL EMERGENCY CARE LA English DT Article DE pharmacokinetics; pralidoxime chloride; intraosseous; hemorrhage shock; swine ID HOSPITAL CARDIAC-ARREST; VASCULAR ACCESS; RESUSCITATION; INFUSION; EFFICACY; CHILDREN AB Objective. Exposure to nerve agents requires prompt treatment. We hypothesized that intraosseous (IO) injections of drug antidotes into the vascularized bone marrow will provide a more rapid and effective means to treat exposure to nerve agents than standard intramuscular (IM) injections. We compared the pharmacokinetics of IM and IO administration of pralidoxime chloride (2-PAM Cl) during normovolemia and hypovolemia, as well as their combined administration during normovolemia in swine. Methods. Ten normovolemic swine were randomly administered 2mL, 660mg 2-PAM Cl via the IM or IO route and monitored for 180 minutes. IM versus IO also was compared in 8 hypovolemic swine bled to a mean arterial pressure of 50 mmHg. In a combined group, an IO injection was administered followed by an IM injection 60 minutes later. Blood samples were collected at times over a 180-minute period to calculate standard pharmacokinetic variables to compare the 2 routes of administration. Results. In the normovolemic swine, IM injection achieved therapeutic levels (4g/mL) in 2 minutes, whereas IO infusion achieved these levels in less than 15 seconds. 2-PAM-Cl concentrations fell below these levels at 60 minutes post-injection in both groups. In the hypovolemic swine, IM injection achieved therapeutic levels in 4 minutes compared to less than 15 seconds in the IO group. 2-PAM-Cl concentrations fell below therapeutic levels at 12 and 90 minutes post-injection in the IM and IO groups, respectively. In the combined IO-IM treatment, plasma levels remained above therapeutic levels for the entire experiment and had two concentration peaks that corresponded to IO and IM injections. Conclusions. The IO route for the delivery of 2-PAM Cl provides a significant time and high initial blood concentrations advantage compared to the IM route for the prehospital treatment of nerve agent exposure even under hypovolemic conditions. The initial concentration peak associated with IO, but not IM, may provide greater initial therapy at the most critical time. C1 [Uwaydah, Nabeel I.; Hoskins, Stephen L.; Copper, Nick C.; Deyo, Donald J.; Kramer, George C.] Univ Texas Med Branch, Dept Anesthesiol, Resuscitat Res Lab, Galveston, TX 77555 USA. [Bruttig, Stephen P.] Resuscitat Solut Inc, Galveston, TX USA. [Bruttig, Stephen P.; Farrar, Henry] Univ Arkansas, Sch Med, Pediat Clin Pharmacol, Little Rock, AR 72204 USA. [Farrar, Henry; Dubick, Michael A.] US Army Inst Surg Res, San Antonio, TX USA. RP Kramer, GC (reprint author), Univ Texas Med Branch, Dept Anesthesiol, 301 Univ Blvd, Galveston, TX 77555 USA. EM gkramer@utmb.edu FU SBIR FX SBIR 1R43A148393-01A1/CFDA: 93.855; NIAID; CRADA UTMB & US Army Medical Research and Materiel Command, "Resuscitation Solutions to Circulatory Shock." This study was partially funded by an SBIR grant and was performed under a Cooperative Research and Development Agreement between UTMB and the US Army Institute of Surgical Research. NR 24 TC 0 Z9 0 U1 1 U2 1 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1090-3127 EI 1545-0066 J9 PREHOSP EMERG CARE JI Prehosp. Emerg. Care PD JUL-AUG PY 2016 VL 20 IS 4 BP 485 EP 492 DI 10.3109/10903127.2014.942479 PG 8 WC Emergency Medicine; Public, Environmental & Occupational Health SC Emergency Medicine; Public, Environmental & Occupational Health GA DS9LG UT WOS:000381103900007 PM 27158860 ER PT J AU Hong, HX Harvey, BG Palmese, GR Stanzione, JF Ng, HW Sakkiah, S Tong, WD Sadler, JM AF Hong, Huixiao Harvey, Benjamin G. Palmese, Giuseppe R. Stanzione, Joseph F., III Ng, Hui Wen Sakkiah, Sugunadevi Tong, Weida Sadler, Joshua M. TI Experimental Data Extraction and in Silico Prediction of the Estrogenic Activity of Renewable Replacements for Bisphenol A SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH LA English DT Article DE bio-based; BPA replacement; endocrine disruption ER ID ACTIVITY-RELATIONSHIP MODELS; STRUCTURE ELUCIDATION; EXPERT-SYSTEM; RECEPTOR BINDING; DECISION FOREST; THERMOSETTING RESINS; SUBSTRUCTURE CONSTRAINTS; CYTOCHROME-P450 CYP3A4; KNOWLEDGE-BASE; CHEMICALS AB Bisphenol A (BPA) is a ubiquitous compound used in polymer manufacturing for a wide array of applications; however, increasing evidence has shown that BPA causes significant endocrine disruption and this has raised public concerns over safety and exposure limits. The use of renewable materials as polymer feedstocks provides an opportunity to develop replacement compounds for BPA that are sustainable and exhibit unique properties due to their diverse structures. As new bio-based materials are developed and tested, it is important to consider the impacts of both monomers and polymers on human health. Molecular docking simulations using the Estrogenic Activity Database in conjunction with the decision forest were performed as part of a two-tier in silico model to predict the activity of 29 bio-based platform chemicals in the estrogen receptor-alpha (ER alpha). Fifteen of the candidates were predicted as ER binders and fifteen as non-binders. Gaining insight into the estrogenic activity of the bio-based BPA replacements aids in the sustainable development of new polymeric materials. C1 [Hong, Huixiao; Ng, Hui Wen; Sakkiah, Sugunadevi; Tong, Weida] US FDA, Div Bioinformat & Biostat, Natl Ctr Toxicol Res, 3900 NCTR Rd, Jefferson, AR 72079 USA. [Harvey, Benjamin G.] Naval Air Warfare Ctr Weap Div, Res Dept, Div Chem, Ridgecrest, CA 93555 USA. [Palmese, Giuseppe R.] Drexel Univ, Dept Chem & Biol Engn, 3141 Chestnut St, Philadelphia, PA 19104 USA. [Stanzione, Joseph F., III] Rowan Univ, Dept Chem Engn, Glassboro, NJ 08028 USA. [Sadler, Joshua M.] RDRL WMM C, Army Res Lab, 4600 Deer Creek Loop, Aberdeen, MD 21005 USA. RP Hong, HX (reprint author), US FDA, Div Bioinformat & Biostat, Natl Ctr Toxicol Res, 3900 NCTR Rd, Jefferson, AR 72079 USA.; Sadler, JM (reprint author), RDRL WMM C, Army Res Lab, 4600 Deer Creek Loop, Aberdeen, MD 21005 USA. EM huixiao.hong@fda.hhs.gov; benjamin.g.harvey@navy.mil; grp27@drexel.edu; stanzione@rowan.edu; ng.huiwen@yahoo.com; Suguna.Sakkiah@fda.hhs.gov; Weida.Tong@fda.hhs.gov; joshua.m.sadler4@mail.mil FU U.S. Department of Energy; U.S. Food and Drug Administration; U.S. Department of Defense [SERDP WP-2402, SERDP WP-2214]; Office of Naval Research; Army Research Laboratory [W911NF-14-2-0086]; Rowan University FX This research was supported in part by an appointment to the Research Participation Program at the National Center for Toxicological Research (Hui Wen Ng, Sugunadevi Sakkiah) administered by the Oak Ridge Institute for Science and Education through an inter-agency agreement between the U.S. Department of Energy and the U.S. Food and Drug Administration. This research was supported by the U.S. Department of Defense, through the Strategic Environmental Research and Development Program (SERDP WP-2402, SERDP WP-2214), and the Office of Naval Research. Additionally, this research was support by the Army Research Laboratory through the Cooperative Agreement W911NF-14-2-0086 with Rowan University. NR 65 TC 3 Z9 3 U1 4 U2 6 PU MDPI AG PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 1660-4601 J9 INT J ENV RES PUB HE JI Int. J. Environ. Res. Public Health PD JUL PY 2016 VL 13 IS 7 AR 705 DI 10.3390/ijerph13070705 PG 16 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA DS4OG UT WOS:000380759800081 ER PT J AU Kheirabadi, BS Miranda, N Terrazas, IB Voelker, AN Grimm, RC Dubick, MA AF Kheirabadi, Bijan Shams Miranda, Nahir Terrazas, Irasema B. Voelker, Amber N. Grimm, Rose C. Dubick, Michael A. TI Influences of limited resuscitation with plasma or plasma protein solutions on hemostasis and survival of rabbits with noncompressible hemorrhage SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article; Proceedings Paper CT 29th Annual Meeting of the Eastern-Association-for-the-Surgery-of-Trauma CY JAN 09-16, 2016 CL San Antonio, TX SP Eastern Assoc Surg Trauma DE 25% Albumin; fibrinogen; New Zealand white rabbit uncontrolled hemorrhage; plasma; prehospital resuscitation ID TRAUMATIC BRAIN-INJURY; FRESH-FROZEN PLASMA; RECEIVING MASSIVE TRANSFUSIONS; NATURAL COLLOID RESUSCITATION; DILUTIONAL COAGULOPATHY; FLUID RESUSCITATION; FIBRINOGEN CONCENTRATE; INCREASING HEMORRHAGE; MORTALITY; SALINE AB BACKGROUND: Plasma infusion with or without red blood cells is the current military standard of care for prehospital resuscitation of combat casualties. We examined possible advantages of early and limited resuscitation with fresh plasma compared with a single plasma protein or crystalloid solutions in an uncontrolled hemorrhage model in rabbits. METHODS: Anesthetized spontaneously breathing rabbits (3.3 +/- 0.1 kg) were instrumented and subjected to a splenic uncontrolled hemorrhage. Rabbits in shock were resuscitated at 15 minutes with Plasma-Lyte (PAL; 30 mL/kg), PAL + fibrinogen (PAL + F; 30 mL + 100 mg/kg), fresh rabbit plasma (15 mL/kg), or 25% albumin (ALB; 5 mL/kg) solution, all given in two bolus intravenous injections (15 minutes apart) to achieve a mean arterial pressure of 65 mm Hg, n = 8 to 9/group. Animals were monitored for 2 hours or until death, and blood loss was measured. Blood samples and tissues were collected and analyzed. RESULTS: There were no differences among groups in baseline measures and their initial bleeding volume at 15 minutes. At 60 minutes after injury, mean arterial pressure was higher with ALB than with crystalloids (PAL or PAL + F), but shock indices were not different despite the large differences in resuscitation volumes. Fibrinogen addition to PAL only increased clot strength. Plasma resuscitation increased survival rate (75%) without significant improvement in coagulation measures. Albumin administration replenished total plasma protein and increased survival rate to 100% (p < .05 vs. crystalloids). No histological adverse events were identified in the vital organs. CONCLUSIONS: Fibrinogen administration added to a compatible crystalloid did not improve hemostatic outcomes. Plasma resuscitation increased survival rate; however, its effects did not differ from those obtained with 25% ALB at one-third of the volume. The ALB advantage was consistent with our previous findings in which 5% ALB was used at a volume equal to plasma. The benefit of plasma for resuscitation may be mostly due to its ALB content rather than its coagulation proteins. (J Trauma Acute Care Surg. 2016; 81: 42-49. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.) C1 [Kheirabadi, Bijan Shams; Miranda, Nahir; Terrazas, Irasema B.; Voelker, Amber N.; Grimm, Rose C.; Dubick, Michael A.] US Army Inst Surg Res, JBSA, Ft Sam Houston, TX USA. RP Kheirabadi, BS (reprint author), 3650 Chambers Pass,BHT2,Bldg 3610, Ft Sam Houston, TX 78234 USA. EM Bijan.s.kheirabadi.civ@mail.mil NR 37 TC 1 Z9 1 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD JUL PY 2016 VL 81 IS 1 BP 42 EP 49 DI 10.1097/TA.0000000000001091 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA DS5BV UT WOS:000380796400008 PM 27120325 ER PT J AU Le, TD Orman, JA Stockinger, ZT Spott, MA West, SA Mann-Salinas, EA Chung, KK Gross, KR AF Le, Tuan D. Orman, Jean A. Stockinger, Zsolt T. Spott, Mary Ann West, Susan A. Mann-Salinas, Elizabeth A. Chung, Kevin K. Gross, Kirby R. TI The Military Injury Severity Score (mISS): A better predictor of combat mortality than Injury Severity Score (ISS) SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article; Proceedings Paper CT 29th Annual Meeting of the Eastern-Association-for-the-Surgery-of-Trauma CY JAN 09-16, 2016 CL San Antonio, TX SP Eastern Assoc Surg Trauma DE Combat mortality; mAIS; Military Abbreviated Injury Scale; Military Injury Severity Score; mISS ID OPERATING CHARACTERISTIC CURVES; ICD-9 DIAGNOSIS CODES; LENGTH-OF-STAY; IMPROVES ACCURACY; TRAUMA SYSTEM; CARE; WAR; AFGHANISTAN; AREAS; SCALE AB BACKGROUND: The Military Injury Severity Score (mISS) was developed to better predict mortality in complex combat injuries but has yet to be validated. METHODS: US combat trauma data from Afghanistan and Iraq from January 1, 2003, to December 31, 2014, from the US Department of Defense Trauma Registry (DoDTR) were analyzed. Military ISS, a variation of the ISS, was calculated and compared with standard ISS scores. Receiver operating characteristic curve, area under the curve, and Hosmer-Lemeshow statistics were used to discriminate and calibrate between mISS and ISS. Wilcoxon-Mann-Whitney, t test and chi(2) tests were used, and sensitivity and specificity calculated. Logistic regression was used to calculate the likelihood of mortality associated with levels of mISS and ISS overall. RESULTS: Thirty thousand three hundred sixty-four patients were analyzed. Most were male (96.8%). Median age was 24 years (interquartile range [IQR], 21-29 years). Battle injuries comprised 65.3%. Penetrating (39.5%) and blunt (54.2%) injury types and explosion (51%) and gunshot wound (15%) mechanisms predominated. Overall mortality was 6.0%. Median mISS and ISS were similar in survivors (5 [IQR, 2-10] vs. 5 [IQR, 2-10]) but different in nonsurvivors, 30 (IQR, 16-75) versus 24 (IQR, 9-23), respectively (p < 0.0001). Military ISS and ISS were discordant in 17.6% (n = 5,352), accounting for 56.2% (n = 1,016) of deaths. Among cases with discordant severity scores, the median difference between mISS and ISS was 9 (IQR, 7-16); range, 1 to 59. Military ISS and ISS shared 78% variability (R-2 = 0.78). Area under the curve was higher in mISS than in ISS overall (0.82 vs. 0.79), for battle injury (0.79 vs. 0.76), non-battle injury (0.87 vs. 0.86), penetrating (0.81 vs. 0.77), blunt (0.77 vs. 0.75), explosion (0.81 vs. 0.78), and gunshot (0.79 vs. 0.73), all p < 0.0001. Higher mISS and ISS were associated with higher mortality. Compared with ISS, mISS had higher sensitivity (81.2 vs. 63.9) and slightly lower specificity (80.2 vs. 85.7). CONCLUSION: Military ISS predicts combat mortality better than does ISS. (J Trauma Acute Care Surg. 2016; 81: 114-121. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.) C1 [Le, Tuan D.; Stockinger, Zsolt T.; Spott, Mary Ann; West, Susan A.; Gross, Kirby R.] Joint Trauma Syst, Ft Sam Houston, TX USA. [Le, Tuan D.; Orman, Jean A.; Mann-Salinas, Elizabeth A.; Chung, Kevin K.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Le, TD (reprint author), US Army Inst Surg Res, San Antonio Mil Med Ctr, JBSA, 3698 Chambers Pass,Ste B,Bldg 3611, Ft Sam Houston, TX 78234 USA. EM tuan.d.le5.civ@mail.mil NR 35 TC 1 Z9 1 U1 2 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD JUL PY 2016 VL 81 IS 1 BP 114 EP 121 DI 10.1097/TA.0000000000001032 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA DS5BV UT WOS:000380796400018 PM 26958797 ER PT J AU Kulkarni, SG Gao, XL Horner, SE Mortlock, RF Zheng, JQ AF Kulkarni, S. G. Gao, X-L Horner, S. E. Mortlock, R. F. Zheng, J. Q. TI A transversely isotropic visco-hyperelastic constitutive model for soft tissues SO MATHEMATICS AND MECHANICS OF SOLIDS LA English DT Article DE Soft tissue; constitutive model; hyperelastic material; transversely isotropic material; strain energy; viscous potential; strain rate; elasticity tensor; viscosity tensor ID NONLINEARLY ELASTIC SOLIDS; HUMAN ANNULUS FIBROSUS; TRAUMATIC BRAIN-INJURY; DYNAMIC STRAIN RATES; MECHANICAL-BEHAVIOR; BIOLOGICAL TISSUES; INVARIANT FORMULATION; LARGE-DEFORMATION; SHEAR PROPERTIES; ENERGY FUNCTIONS AB A transversely isotropic visco-hyperelastic constitutive model is provided for soft tissues, which accounts for large deformations, high strain rates, and short-term memory effects. In the first part, a constitutive model for quasi-static deformations of soft tissues is presented, in which a soft tissue is simulated as a transversely isotropic hyperelastic material composed of a matrix and reinforcing fibers. The strain energy density function for the soft tissue is additively decomposed into two terms: a neo-Hookean function for the base matrix, and a polyconvex polynomial function of four invariants for the fibers. A comparison with existing experimental data for porcine brain tissues and bovine pericardium shows that this new model can well represent the quasi-static mechanical behavior of soft tissues. In the second part, a viscous potential is proposed to describe the rate-dependent short-term memory effects, resulting in a visco-hyperelastic constitutive model. This model is tested for a range of strain rates from 0.1 /s to 90 /s and for multiple loading scenarios based on available experimental data for porcine and human brain tissues. The model can be applied to other soft tissues by using different values of material and fitting parameters. C1 [Kulkarni, S. G.] Dassault Systemes Simulia Corp, Providence, RI USA. [Gao, X-L] Southern Methodist Univ, Dept Mech Engn, Dallas, TX 75275 USA. [Horner, S. E.; Mortlock, R. F.; Zheng, J. Q.] US Army, Program Execut Off SOLDIER, Hampton, VA USA. RP Gao, XL (reprint author), Southern Methodist Univ, Dept Mech Engn, Dallas, TX 75275 USA. EM xlgao@smu.edu FU US Army FX The work reported here is partially funded by a contract from the US Army. This support is gratefully acknowledged. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of the US Army. NR 66 TC 1 Z9 1 U1 9 U2 9 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1081-2865 EI 1741-3028 J9 MATH MECH SOLIDS JI Math. Mech. Solids PD JUL PY 2016 VL 21 IS 6 BP 747 EP 770 DI 10.1177/1081286514536921 PG 24 WC Materials Science, Multidisciplinary; Mathematics, Interdisciplinary Applications; Mechanics SC Materials Science; Mathematics; Mechanics GA DS7WX UT WOS:000380994800008 ER PT J AU Soule, CW Lazarus, N AF Soule, Cody W. Lazarus, Nathan TI Reconfigurable Braille display with phase change locking SO SMART MATERIALS AND STRUCTURES LA English DT Article DE phase change; Braille; reconfigurable; field's metal; 3D printing; actuation ID TACTILE DISPLAY; ACTUATOR; CELL AB Automatically updated signs and displays for sighted people are common in today's world. However, there is no cheap, low power equivalent available for the blind. This work demonstrates a reconfigurable Braille cell using the solid-to-liquid phase change of a low melting point alloy as a zero holding power locking mechanism. The device is actuated with the alloy in the liquid state, and is then allowed to solidify to lock the Braille dot in the actuated position. A low-cost manufacturing process is developed that includes molding of a rigid silicone to create pneumatic channels, and bonding of a thin membrane of a softer silicone on the surface for actuation. A plug of Field's metal (melting point 62 degrees C) is placed in the pneumatic channels below each Braille dot to create the final device. The device is well suited for low duty cycle operation in applications such as signs, and is able to maintain its state indefinitely without additional power input. The display requires a pneumatic pressure of only 24 kPa for actuation, and reconfiguration has been demonstrated in less than a minute and a half. C1 [Soule, Cody W.] Rochester Inst Technol, Microelect Engn Dept, 1 Lomb Mem Dr, Rochester, NY 14623 USA. [Lazarus, Nathan] US Army, Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Lazarus, N (reprint author), US Army, Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM cws7035@rit.edu; Nathan.lazarus2.civ@mail.mil NR 30 TC 0 Z9 0 U1 5 U2 5 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0964-1726 EI 1361-665X J9 SMART MATER STRUCT JI Smart Mater. Struct. PD JUL PY 2016 VL 25 IS 7 AR 075040 DI 10.1088/0964-1726/25/7/075040 PG 7 WC Instruments & Instrumentation; Materials Science, Multidisciplinary SC Instruments & Instrumentation; Materials Science GA DT5IY UT WOS:000381517900043 ER PT J AU Wright, RW Huston, LJ Nwosu, SK Haas, AK Allen, CR Anderson, AF Cooper, DE DeBerardino, TM Dunn, WR Lantz, BA Mann, B Spindler, KP Stuart, MJ Albright, JP Amendola, A Andrish, JT Annunziata, CC Arciero, RA Bach, BR Baker, CL Bartolozzi, AR Baumgarten, KM Bechler, JR Berg, JH Bernas, GA Brockmeier, SF Brophy, RH Bush-Joseph, CA Butler, JB Campbell, JD Carey, JL Carpenter, JE Cole, BJ Cooper, JM Cox, CL Creighton, RA Dahm, DL David, TS Flanigan, DC Frederick, RW Ganley, TJ Garofoli, EA Gatt, CJ Gecha, SR Giffin, JR Hame, SL Hannafin, JA Harner, CD Harris, NL Hechtman, KS Hershman, EB Hoellrich, RG Hosea, TM Johnson, DC Johnson, TS Jones, MH Kaeding, CC Kamath, GV Klootwyk, TE Levy, BA Ma, CB Maiers, GP Marx, RG Matava, MJ Mathien, GM McAllister, DR McCarty, EC McCormack, RG Miller, BS Nissen, CW O'Neill, DF Owens, BD Parker, RD Purnell, ML Ramappa, AJ Rauh, MA Rettig, AC Sekiya, JK Shea, KG Sherman, OH Slauterbeck, JR Smith, MV Spang, JT Svoboda, SJ Taft, TN Tenuta, JJ Tingstad, EM Vidal, AF Viskontas, DG White, RA Williams, JS Wolcott, ML Wolf, BR York, JJ AF Wright, Rick W. Huston, Laura J. Nwosu, Sam K. Haas, Amanda K. Allen, Christina R. Anderson, Allen F. Cooper, Daniel E. DeBerardino, Thomas M. Dunn, Warren R. Lantz, Brett A. Mann, Barton Spindler, Kurt P. Stuart, Michael J. Albright, John P. Amendola, Annunziato Andrish, Jack T. Annunziata, Christopher C. Arciero, Robert A. Bach, Bernard R., Jr. Baker, Champ L., III Bartolozzi, Arthur R. Baumgarten, Keith M. Bechler, Jeffery R. Berg, Jeffrey H. Bernas, Geoffrey A. Brockmeier, Stephen F. Brophy, Robert H. Bush-Joseph, Charles A. Butler, J. Brad Campbell, John D. Carey, James L. Carpenter, James E. Cole, Brian J. Cooper, Jonathan M. Cox, Charles L. Creighton, R. Alexander Dahm, Diane L. David, Tal S. Flanigan, David C. Frederick, Robert W. Ganley, Theodore J. Garofoli, Elizabeth A. Gatt, Charles J., Jr. Gecha, Steven R. Giffin, James Robert Hame, Sharon L. Hannafin, Jo A. Harner, Christopher D. Harris, Norman Lindsay, Jr. Hechtman, Keith S. Hershman, Elliott B. Hoellrich, Rudolf G. Hosea, Timothy M. Johnson, David C. Johnson, Timothy S. Jones, Morgan H. Kaeding, Christopher C. Kamath, Ganesh V. Klootwyk, Thomas E. Levy, Bruce A. Ma, C. Benjamin Maiers, G. Peter, II Marx, Robert G. Matava, Matthew J. Mathien, Gregory M. McAllister, David R. McCarty, Eric C. McCormack, Robert G. Miller, Bruce S. Nissen, Carl W. O'Neill, Daniel F. Owens, Brett D. Parker, Richard D. Purnell, Mark L. Ramappa, Arun J. Rauh, Michael A. Rettig, Arthur C. Sekiya, Jon K. Shea, Kevin G. Sherman, Orrin H. Slauterbeck, James R. Smith, Matthew V. Spang, Jeffrey T. Svoboda, Steven J. Taft, Timothy N. Tenuta, Joachim J. Tingstad, Edwin M. Vidal, Armando F. Viskontas, Darius G. White, Richard A. Williams, James S., Jr. Wolcott, Michelle L. Wolf, Brian R. York, James J. CA MARS Group TI Meniscal and Articular Cartilage Predictors of Clinical Outcome After Revision Anterior Cruciate Ligament Reconstruction SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE anterior cruciate ligament; revision ACL reconstruction; meniscus; articular cartilage; chondrosis; predictors; outcomes ID PATELLAR BONE AUTOGRAFT; FOLLOW-UP; PARTIAL MENISCECTOMY; TENDON AUTOGRAFT; REPEAT REVISION; SURGERY; OSTEOARTHRITIS; LESIONS; TEARS; ASSOCIATION AB Background: Revision anterior cruciate ligament (ACL) reconstruction has been documented to have worse outcomes compared with primary ACL reconstructions. Purpose/Hypothesis: The purpose of this study was to determine if the prevalence, location, and/or degree of meniscal and chondral damage noted at the time of revision ACL reconstruction predicts activity level, sports function, and osteoarthritis symptoms at 2-year follow-up. The hypothesis was that meniscal loss and high-grade chondral damage noted at the time of revision ACL reconstruction will result in lower activity levels, decreased sports participation, more pain, more stiffness, and more functional limitation at 2 years after revision surgery. Study Design: Cohort study; Level of evidence, 2. Methods: Between 2006 and 2011, a total of 1205 patients who underwent revision ACL reconstruction by 83 surgeons at 52 hospitals were accumulated for study of the relationship of meniscal and articular cartilage damage to outcome. Baseline demographic and intraoperative data, including the International Knee Documentation Committee (IKDC) subjective knee evaluation, Knee injury and Osteoarthritis Outcome Score (KOOS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Marx activity score, were collected initially and at 2-year follow-up to test the hypothesis. Regression analysis was used to control for age, sex, body mass index, smoking status, activity level, baseline outcome scores, revision number, time since last ACL reconstruction, incidence of having a previous ACL reconstruction on the contralateral knee, previous and current meniscal and articular cartilage injury, graft choice, and surgeon years of experience to assess the meniscal and articular cartilage risk factors for clinical outcomes 2 years after revision ACL reconstruction. Results: At 2-year follow-up, 82% (989/1205) of the patients returned their questionnaires. It was found that previous meniscal injury and current articular cartilage damage were associated with the poorest outcomes, with prior lateral meniscectomy and current grade 3 to 4 trochlear articular cartilage changes having the worst outcome scores. Activity levels at 2 years were not affected by meniscal or articular cartilage pathologic changes. Conclusion: Prior lateral meniscectomy and current grade 3 to 4 changes of the trochlea were associated with worse outcomes in terms of decreased sports participation, more pain, more stiffness, and more functional limitation at 2 years after revision surgery, but they had no effect on activity levels. Registration: NCT00625885 C1 [Wright, Rick W.; Haas, Amanda K.; Brophy, Robert H.; Garofoli, Elizabeth A.; Matava, Matthew J.; Smith, Matthew V.] Washington Univ, St Louis, MO USA. [Huston, Laura J.; Nwosu, Sam K.; Cox, Charles L.] Vanderbilt Univ, Nashville, TN USA. [Allen, Christina R.; Ma, C. Benjamin] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Anderson, Allen F.] Tennessee Orthopaed Alliance, Nashville, TN USA. [Cooper, Daniel E.] WB Carrell Mem Clin, Dallas, TX USA. [DeBerardino, Thomas M.] Univ Connecticut, Ctr Hlth, Storrs, CT USA. [Dunn, Warren R.] Univ Wisconsin, Madison, WI 53706 USA. [Lantz, Brett A.; Hoellrich, Rudolf G.] Slocum Res & Educ Fdn, Eugene, OR USA. [Mann, Barton; Spindler, Kurt P.; Andrish, Jack T.; Jones, Morgan H.; Parker, Richard D.; Williams, James S., Jr.] Cleveland Clin, Cleveland, OH USA. [Stuart, Michael J.; Dahm, Diane L.; Levy, Bruce A.] Mayo Clin Rochester, Rochester, MN USA. [Albright, John P.; Amendola, Annunziato; Wolf, Brian R.] Univ Iowa Hosp & Clin, Iowa City, IA USA. [Annunziata, Christopher C.] Commonwealth Orthopaed & Rehab, Arlington, VA USA. [Arciero, Robert A.] Univ Connecticut, Ctr Hlth, Storrs, CT USA. [Bach, Bernard R., Jr.; Bush-Joseph, Charles A.; Cole, Brian J.] Rush Univ, Med Ctr, Chicago, IL USA. [Baker, Champ L., III] Hughston Clin, Dothan, AL USA. [Bartolozzi, Arthur R.] Univ Penn Hlth Syst, Orthopaed 03B, Philadelphia, PA USA. [Baumgarten, Keith M.] Inst Orthoped, Sioux Falls, SD USA. [Bechler, Jeffery R.; Gatt, Charles J., Jr.; Hosea, Timothy M.] Univ Orthoped Associates LLC, Somerset, NJ USA. [Berg, Jeffrey H.] Town Ctr Orthopaed Associates, Reston, VA USA. [Bernas, Geoffrey A.; Rauh, Michael A.] SUNY Buffalo, Buffalo, NY USA. [Brockmeier, Stephen F.] Univ Virginia, Charlottesville, VA 22903 USA. [Butler, J. Brad] Orthoped & Fracture Clin, Portland, OR USA. [Campbell, John D.] Bridger Orthopaed & Sports Med, Bozeman, MT USA. [Carey, James L.] Univ Penn, Philadelphia, PA 19104 USA. [Carpenter, James E.; Miller, Bruce S.; Sekiya, Jon K.] Univ Michigan, Ann Arbor, MI 48109 USA. [Cooper, Jonathan M.] HealthPartners Specialty Clin, St Paul, MN USA. [Creighton, R. Alexander; Kamath, Ganesh V.; Spang, Jeffrey T.; Taft, Timothy N.] Univ N Carolina, Med Ctr, Chapel Hill, NC USA. [David, Tal S.] Arthroscop & Orthoped Sports Med Associates, San Diego, CA USA. [Flanigan, David C.; Kaeding, Christopher C.] Ohio State Univ, Columbus, OH 43210 USA. [Frederick, Robert W.] Thomas Jefferson Univ, Rothman Inst, Philadelphia, PA USA. [Ganley, Theodore J.] Childrens Hosp Philadelphia, Philadelphia, PA USA. [Gecha, Steven R.] Princeton Orthopaed Associates, Princeton, NJ USA. [Giffin, James Robert] Univ Western Ontario, Fowler Kennedy Sports Med Clin, London, ON N6A 3K7, Canada. [Hame, Sharon L.; McAllister, David R.] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90024 USA. [Hannafin, Jo A.; Marx, Robert G.] Hosp Special Surg, New York, NY USA. [Harner, Christopher D.] Univ Pittsburgh, Med Ctr, Pittsburgh, PA 15260 USA. [Harris, Norman Lindsay, Jr.; Purnell, Mark L.] Orthopaed Associates Aspen & Glenwood, Glenwood Springs, CO USA. [Hechtman, Keith S.] UHZ Sports Med Inst, Miami, FL USA. [Hershman, Elliott B.] Lenox Hill Hosp, New York, NY 10021 USA. [Johnson, David C.; Johnson, Timothy S.] Natl Sports Med Inst, Leesburg, VA USA. [Klootwyk, Thomas E.; Maiers, G. Peter, II; Rettig, Arthur C.] Methodist Sports Med Ctr, Indianapolis, IN USA. [Mathien, Gregory M.] Knoxville Orthoped Clin, Knoxville, TN USA. [McCarty, Eric C.; Vidal, Armando F.; Wolcott, Michelle L.] Univ Colorado Denver, Sch Med, Denver, CO USA. [McCormack, Robert G.] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada. [Nissen, Carl W.] Connecticut Childrens Med Ctr, Hartford, CT USA. [O'Neill, Daniel F.] Littleton Reg Hosp, Littleton, NH USA. [Owens, Brett D.] Brown Alpert Med Sch, Providence, RI USA. [Ramappa, Arun J.] Beth Israel Deaconess Med Ctr, Boston, MA USA. [Shea, Kevin G.] Intermt Orthoped, Boise, ID USA. [Sherman, Orrin H.] NYU Hosp Joint Dis, New York, NY USA. [Slauterbeck, James R.] Univ Vermont, Coll Med, Burlington, VT 05405 USA. [Svoboda, Steven J.] US Mil Acad, Keller Army Community Hosp, West Point, NY 10996 USA. [Tenuta, Joachim J.] Albany Med Ctr, Albany, NY USA. [Tingstad, Edwin M.] Inland Orthopaed, Waterville, ME USA. [Tingstad, Edwin M.] Washington State Univ, Pullman, WA 99164 USA. [Viskontas, Darius G.] Royal Columbian Hosp, New Westminster, BC, Canada. [White, Richard A.] Univ Missouri, Columbia, MO USA. [York, James J.] Chesapeake Orthopaed & Sports Med Ctr, Glen Burnie, MD USA. RP Wright, RW (reprint author), Washington Univ, Dept Orthopaed Surg, 660 South Euclid Ave,Campus Box 8233, St Louis, MO 63110 USA. EM wright@wudosis.wustl.edu OI DeBerardino, Thomas/0000-0002-7110-8743 FU AOSSM; Smith Nephew; National Football League Charities; Musculoskeletal Tissue Foundation (MTF); National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIH/NIAMS) [5R01-AR060846] FX One or more of the authors has declared the following potential conflict of interest or source of funding: This study received funding from the AOSSM, Smith & Nephew, National Football League Charities, and Musculoskeletal Tissue Foundation (MTF). This project was partially funded by grant 5R01-AR060846 from the National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIH/NIAMS). NR 38 TC 0 Z9 0 U1 9 U2 10 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 EI 1552-3365 J9 AM J SPORT MED JI Am. J. Sports Med. PD JUL PY 2016 VL 44 IS 7 BP 1671 EP 1679 DI 10.1177/0363546516644218 PG 9 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA DR6MY UT WOS:000380017200008 ER PT J AU Svoboda, SJ Owens, BD Harvey, TM Tarwater, PM Brechue, WF Cameron, KL AF Svoboda, Steven J. Owens, Brett D. Harvey, Travis M. Tarwater, Patrick M. Brechue, William F. Cameron, Kenneth L. TI The Association Between Serum Biomarkers of Collagen Turnover and Subsequent Anterior Cruciate Ligament Rupture SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE anterior cruciate ligament; biology of cartilage; injury prevention; biomarkers; cartilage metabolism; cartilage turnover ID RANDOMIZED CONTROLLED-TRIAL; INJURY PREVENTION PROGRAM; MILITARY SERVICE MEMBERS; KNEE OSTEOARTHRITIS; RISK-FACTORS; II COLLAGEN; ARTICULAR-CARTILAGE; SOCCER PLAYERS; AGE; PROGRESSION AB Background: No study has attempted to associate the levels of preinjury serum biomarkers of collagen turnover with the subsequent risk of anterior cruciate ligament (ACL) injury. Hypothesis: Preinjury serum biomarkers of collagen turnover would be associated with the subsequent risk of ACL injury. Study Design: Case-control study; Level of evidence, 3. Methods: We conducted a case-control study with 45 ACL-injured cases and 45 controls matched for sex, age, height, and weight. In addition to the matching criteria, controls had no history of major joint injury. Baseline preinjury serum samples were obtained from the Department of Defense Serum Repository for all subjects. Samples were assessed for 2 serum biomarkers of collagen synthesis (CPII and CS846) and 2 markers of collagen degradation (C1,2C and C2C) through commercially available enzyme-linked immunosorbent assay (ELISA) kits. All ELISAs were performed in triplicate. Conditional logistic regression models were used to analyze the data. Results: Univariate results suggested that both biomarkers for collagen degradation (C1,2C and C2C) were significantly associated with the subsequent likelihood of ACL injury. Serum C2C and C1,2C concentration at baseline were associated with odds ratios (ORs) of 2.05 (95% CI, 1.30-3.23; P = .001) and 3.02 (95% CI, 1.60-5.71; P = .002), respectively. Baseline serum CPII concentrations were also associated with subsequent ACL injury. Serum CPII concentration at baseline was associated with an OR of 4.41 (95% CI, 1.87-10.38; P = .001). Baseline serum CS846 levels approached significance (OR = 0.77; 95% CI, 0.57-1.03; P = .080). Multivariable models suggested that preinjury CPII and C2C concentrations at baseline are important indicators of subsequent ACL injury risk. Conclusion: Preinjury differences in serum biomarker levels of collagen turnover suggest that collagen metabolism in individuals who go on to tear an ACL may be different when compared with a matched control group with no history of major joint injury. These differences may be reflective of different preinjury biochemical and/or biomechanical risk profiles or genetic factors that subsequently affect both collagen metabolism and ACL injury risk. C1 Keller Army Hosp, West Point, NY USA. US Mil Acad, West Point, NY 10996 USA. [Svoboda, Steven J.; Owens, Brett D.; Cameron, Kenneth L.] Keller Army Hosp, Dept Orthopaed Surg, 900 Washington Rd, West Point, NY 10996 USA. [Brechue, William F.] US Mil Acad, Dept Phys Educ, West Point, NY 10996 USA. [Harvey, Travis M.] 75th Ranger Regiment, Ft Benning, GA USA. [Tarwater, Patrick M.] Texas Tech Univ, Hlth Sci Ctr, Div Biostat & Epidemiol, El Paso, TX USA. RP Svoboda, SJ (reprint author), Keller Army Hosp, Dept Orthopaed Surg, 900 Washington Rd, West Point, NY 10996 USA. EM steven.j.svoboda.mil@mail.mil FU Orthopaedic Research and Education Foundation FX One or more of the authors has declared the following potential conflict of interest or source of funding: This study was aided by a grant from the Orthopaedic Research and Education Foundation. NR 48 TC 3 Z9 3 U1 7 U2 8 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 EI 1552-3365 J9 AM J SPORT MED JI Am. J. Sports Med. PD JUL PY 2016 VL 44 IS 7 BP 1687 EP 1693 DI 10.1177/0363546516640515 PG 7 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA DR6MY UT WOS:000380017200010 PM 27159304 ER PT J AU Hoffman, RR Cullen, TM Hawley, JK AF Hoffman, Robert R. Cullen, Timothy M. Hawley, John K. TI The myths and costs of autonomous weapon systems SO BULLETIN OF THE ATOMIC SCIENTISTS LA English DT Article DE Patriot air defense system; Predator aircraft; autonomous weapon; fratricide; automated weapon systems AB A primary motivation for developing autonomous weapons is the assumption that such systems require fewer combatants with lower levels of expertise, thus cutting costs. For more than two decades, the Defense Department has employed highly automated weapons, including the Patriot air defense system and the Predator aircraft system. For the myths of automation to hold, the human costs of the systems should have fallen as the Army and Air Force became more accustomed to them. But automated weapon systems have actually required more highly trained and experienced experts, and the failure to train personnel to operate the systems adequately has led to fratricide and the loss of innocent life. The Defense Department needs to improve its policies on the procurement and development of automated systems if the weapons are to be responsive and effective in future conflicts. C1 [Hoffman, Robert R.] Inst Human & Machine Cognit, Pensacola, FL 32502 USA. [Hoffman, Robert R.] Human Factors & Ergon Soc, Santa Monica, CA 90406 USA. [Cullen, Timothy M.] Air Univ, Sch Adv Air & Space Studies, Strategy & Secur Studies, Montgomery, AL USA. [Hawley, John K.] US Army Res Lab, Human Res & Engn Directorate, Ft Bliss, TX USA. RP Hoffman, RR (reprint author), Inst Human & Machine Cognit, Pensacola, FL 32502 USA.; Hoffman, RR (reprint author), Human Factors & Ergon Soc, Santa Monica, CA 90406 USA. EM rhoffman@ihmc.us NR 25 TC 0 Z9 0 U1 6 U2 6 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0096-3402 EI 1938-3282 J9 B ATOM SCI JI Bull. Atom. Scient. PD JUL PY 2016 VL 72 IS 4 BP 247 EP 255 DI 10.1080/00963402.2016.1194619 PG 9 WC International Relations; Social Issues SC International Relations; Social Issues GA DS6MZ UT WOS:000380897400009 ER PT J AU Palinkas, CM Barth, N Koch, EW Shafer, DJ AF Palinkas, Cindy M. Barth, Nicole Koch, Evamaria W. Shafer, Deborah J. TI The Influence of Breakwaters on Nearshore Sedimentation Patterns in Chesapeake Bay, USA SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE Grain size; accumulation rates; shoreline structures; Pb-210 ID COASTAL DEFENSE STRUCTURES; SEA-LEVEL RISE; AQUATIC VEGETATION; HABITAT REQUIREMENTS; ADRIATIC SEA; RIVER; ACCUMULATION; BE-7; ESTUARY; PB-210 AB This study describes nearshore Chesapeake Bay sedimentation at sites adjacent to and landward of 24 segmented breakwaters, varying in age (1-19 years) and physical setting. Grain-size and organic-content profiles are examined at the breakwater-protected sites to assess potential changes induced by breakwater installation as well as at the adjacent-exposed sites to establish historical trends. Sedimentation rates at all sites are calculated with Pb-210 (half-life 22.3 years). At the breakwater-protected sites, these rates largely reflect preconstruction sedimentation because of the long half-life of Pb-210 relative to breakwater ages. Determining the postconstruction sedimentation rate can be more difficult because the signature of breakwater influence in the sedimentological record can be obscured. For example, if the source of sediment is not affected dramatically by construction, down-core profiles may not have obvious changes. The depth of breakwater influence, however, can be interpreted by considering all the sedimentological evidence at a given location, and the postconstruction rates are calculated from this depth. In general, the sedimentological response to breakwater construction is fairly unique for each location but depends on such factors as breakwater age and geometry, shoreline sediment composition, and construction technique. C1 [Palinkas, Cindy M.] Univ Maryland, Ctr Environm Sci, Horn Point Lab, Cambridge, MD 21613 USA. [Shafer, Deborah J.] Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Barth, Nicole] Chesapeake Coll, Wye Mills, MD 21679 USA. RP Palinkas, CM (reprint author), Univ Maryland, Ctr Environm Sci, Horn Point Lab, Cambridge, MD 21613 USA. EM cpalinkas@umces.edu FU Army Corps of Engineers [W912HZ-08-2-0017] FX The authors would like to thank the Army Corps of Engineers (award W912HZ-08-2-0017) for funding this study. We also thank Dale Booth, who provided invaluable field and lab assistance. Numerous other students and interns also assisted in the field and lab, and we are grateful for their contributions. This is UMCES Contribution #4981. NR 61 TC 0 Z9 0 U1 4 U2 4 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 EI 1551-5036 J9 J COASTAL RES JI J. Coast. Res. PD JUL PY 2016 VL 32 IS 4 BP 788 EP 799 DI 10.2112/JCOASTRES-D-14-00138.1 PG 12 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA DS5OU UT WOS:000380832400006 ER PT J AU Houston, JR AF Houston, J. R. TI Discussion of: Boon, JD and Mitchell, M., 2015. Nonlinear Change in Sea Level Observed at North American Tide Stations. Journal of Coastal Research, 31(6), 1295-1305. SO JOURNAL OF COASTAL RESEARCH LA English DT Editorial Material ID ACCELERATION; RISE AB Boon and Mitchell determined sea-level acceleration using monthly averaged relative mean sea-level data from 45 U.S. tide stations and 1 Canadian station for 1969-2014. Their methods of analyzing tide gauge data are interesting and useful. However, they then projected sea-level change for 58 years from 1992-2050 based on constant accelerations calculated from these 46-year records. Calculations of acceleration based on records as short as 40-50 years are well known to be heavily corrupted by decadal variations in sea level. For example, Boon and Mitchell showed that 3-6 year variations in record length or time period resulted in what they said were "dramatic change" in calculated acceleration. Therefore, the accelerations they calculated did not even remain constant for a few years, making long-term projections based on them untenable. Boon and Mitchell projected significant sea-level falls from 1992 to 2050 on the coasts of California, Oregon, and Washington, in stark contrast with projections of significant rises by the National Research Council. Similarly, their projections on the U.S. Atlantic and Pacific coasts differ remarkably from projections of the Intergovernmental Panel on Climate Change. Acceleration calculated from 46-year records varies significantly through time, and it is not valid to fix an acceleration value and project it into the future as if it were a constant. C1 [Houston, J. R.] US Army Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Houston, JR (reprint author), US Army Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM james.r.houston@usace.army.mil NR 14 TC 1 Z9 1 U1 3 U2 5 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 EI 1551-5036 J9 J COASTAL RES JI J. Coast. Res. PD JUL PY 2016 VL 32 IS 4 BP 983 EP 987 DI 10.2112/JCOASTRES-D-15-00251.1 PG 5 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA DS5OU UT WOS:000380832400023 ER PT J AU Aroniadou-Anderjaska, V Apland, JP Braga, MF AF Aroniadou-Anderjaska, Vassiliki Apland, James P. Braga, Maria F. TI The Anticonvulsant and Neuroprotective Efficacy of GluK1 Receptor Antagonists: A Novel Therapeutic Against Nerve Agent-induced Seizures and Brain Damage SO NEUROTHERAPEUTICS LA English DT Meeting Abstract C1 [Aroniadou-Anderjaska, Vassiliki; Braga, Maria F.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA. [Aroniadou-Anderjaska, Vassiliki; Braga, Maria F.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Psychiat, Bethesda, MD 20814 USA. [Apland, James P.] US Army Med Res Inst Chem Def, Neurotoxicol Branch, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1933-7213 EI 1878-7479 J9 NEUROTHERAPEUTICS JI Neurotherapeutics PD JUL PY 2016 VL 13 IS 3 BP 652 EP 652 PG 1 WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy SC Neurosciences & Neurology; Pharmacology & Pharmacy GA DS3JP UT WOS:000380679400033 ER PT J AU Amani, M Burke, RA Ji, X Zhao, P Lien, DH Taheri, P Ahn, GH Kirya, D Ager, JW Yablonovitch, E Kong, J Dubey, M Jayey, A AF Amani, Matin Burke, Robert A. Ji, Xiang Zhao, Peida Lien, Der-Hsien Taheri, Peyman Ahn, Geun Ho Kirya, Daisuke Ager, Joel W., III Yablonovitch, Eli Kong, Jing Dubey, Madan Jayey, Ali TI High Luminescence Efficiency in MoS2 Grown by Chemical Vapor Deposition SO ACS NANO LA English DT Article DE transition metal dichalcogenide; MoS2; chemical vapor deposition; quantum yield; radiative lifetime; biexcitonic recombination ID TRANSITION-METAL DICHALCOGENIDES; MONOLAYER MOLYBDENUM-DISULFIDE; ATOMIC LAYERS; DOUBLE HETEROSTRUCTURES; SPONTANEOUS EMISSION; BAND-GAP; PHOTOLUMINESCENCE; TRANSPORT; GRAPHENE; WS2 AB One of the major challenges facing the rapidly growing field of two-dimensional (2D) transition metal dichalcogenides (TMDCs) is the development of growth techniques to enable large area synthesis of high-quality materials. Chemical vapor deposition (CVD) is one of the leading techniques for the synthesis of TMDCs; however, the quality of the material produced is limited by defects formed during the growth process. A very useful nondestructive technique that can be utilized to probe defects in semiconductors is the room-temperature photoluminescence (PL) quantum yield (QY). It was recently demonstrated that a PL QY near 100% can be obtained in MoS2 and WS2 monolayers prepared by micromechanical exfoliation by treating samples with an organic superacid: bis(trifluoromethane)sulfonimide (TFSI). Here we have performed a thorough exploration of this chemical treatment on CVD-grown MoS2 samples. We find that the as-grown monolayers must be transferred to a secondary substrate, which releases strain, to obtain high QY by TFSI treatment. Furthermore, we find that the sulfur precursor temperature during synthesis of the MoS2 plays a critical role in the effectiveness of the treatment. By satisfying the aforementioned conditions we show that the PL QY of CVD-grown monolayers can be improved from similar to 0.1% in the as-grown case to similar to 30% after treatment, with enhancement factors ranging from 100 to 1500x depending on the initial monolayer quality. We also found that after TFSI treatment the PL emission from MoS2 films was visible by eye despite the low absorption (5-10%). The discovery of an effective passivation strategy will speed the development of scalable high-performance optoelectronic and electronic devices based on MoS2. C1 [Amani, Matin; Zhao, Peida; Lien, Der-Hsien; Taheri, Peyman; Ahn, Geun Ho; Kirya, Daisuke; Yablonovitch, Eli; Jayey, Ali] Univ Calif Berkeley, Elect Engn & Comp Sci, Berkeley, CA 94720 USA. [Amani, Matin; Zhao, Peida; Lien, Der-Hsien; Ahn, Geun Ho; Kirya, Daisuke; Ager, Joel W., III; Yablonovitch, Eli; Jayey, Ali] Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA. [Burke, Robert A.; Dubey, Madan] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Ji, Xiang; Kong, Jing] MIT, Elect Engn & Comp Sci, 77 Mass Ave, Cambridge, MA 02139 USA. RP Jayey, A (reprint author), Univ Calif Berkeley, Elect Engn & Comp Sci, Berkeley, CA 94720 USA.; Jayey, A (reprint author), Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA. EM ajavey@berkeley.edu FU Electronic Materials Program - Office of Science, Office of Basic Energy Sciences, Materials Sciences and Engineering Division of the U.S. Department of Energy [DE-AC02-05CH11231]; NSF Center for Energy Efficient Electronics Science (E3S); U.S. Army Research Lab; Center for Excitonics, an Energy Frontier Research Center - U.S. Department of Energy, Office of Science, Basic Energy Sciences (BES) [DE-SC0001088]; NWO-Rubicon; Office of Science of the U.S. Department of Energy [DE-SC0004993] FX M.A., J.W.A., and A.J. were supported by the Electronic Materials Program, funded by Director, Office of Science, Office of Basic Energy Sciences, Materials Sciences and Engineering Division of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. P.Z., E.Y., J.K., and A.J. acknowledge support from the NSF Center for Energy Efficient Electronics Science (E3S). R.A.B. and M.D. acknowledge support from the U.S. Army Research Lab Director's Strategic Initiative program on interfaces in stacked 2D atomic layers and materials. X.J. acknowledges support from the Center for Excitonics, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Basic Energy Sciences (BES), under award number DE-SC0001088. P.T. was supported by a fellowship awarded by NWO-Rubicon. Raman spectroscopy was performed in collaboration with the Joint Center for Artificial Photosynthesis, a DOE Energy Innovation Hub, supported through the Office of Science of the U.S. Department of Energy under Award Number DE-SC0004993. NR 41 TC 9 Z9 9 U1 80 U2 115 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1936-0851 EI 1936-086X J9 ACS NANO JI ACS Nano PD JUL PY 2016 VL 10 IS 7 BP 6535 EP 6541 DI 10.1021/acsnano.6603443 PG 7 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA DS2FD UT WOS:000380576600016 PM 27291297 ER PT J AU Hennigar, SR Kelley, AM McClung, JP AF Hennigar, Stephen R. Kelley, Alyssa M. McClung, James P. TI Metallothionein and Zinc Transporter Expression in Circulating Human Blood Cells as Biomarkers of Zinc Status: a Systematic Review SO ADVANCES IN NUTRITION LA English DT Review DE metallothionein; zinc transporter; leukocytes; biomarker; zinc status ID TRANSCRIPTION FACTOR MTF-1; GENE-EXPRESSION; DIETARY ZINC; MESSENGER-RNA; MONONUCLEAR-CELLS; YOUNG MEN; ERYTHROCYTE METALLOTHIONEIN; UP-REGULATION; PLASMA ZINC; SUPPLEMENTATION AB Zinc is an essential nutrient for humans; however, a sensitive biomarker to assess zinc status has not been identified. The objective of this systematic review was to compile and assess studies that determined zinc transporter and/or metallothionein expression in various blood cell types and to determine their reliability and sensitivity to changes in dietary zinc. Sixteen studies were identified that determined the expression of zrt-, irt-like protein (ZIP) 1 [solute carrier family (SLC) 39A1], ZIP3 (SLC39A3), ZIP5 (SLC39A5), ZIP6 (SLC39A6), ZIP7 (SLC39A7), ZIP8 (SLC39A8), ZIP10 (SLC39A10), ZIP14 (SLC39A14), zinc transporter (ZnT) 1 (SLC30A1), ZnT2 (SLC30A2), ZnT4 (SLC30A4), ZnT5 (SLC30A5), ZnT6 (SLC30A6), ZnT7 (SLC30A7), ZnT9 (SLC30A9), and/or metallothionein in various blood cells isolated from healthy adult men and women in response to zinc supplementation or depletion. Cell types included leukocytes, peripheral blood mononuclear cells, T lymphocytes, monocytes, and erythrocytes. ZIP1, ZnT1, and metallothionein were the most commonly measured proteins. Changes in ZIP1 and ZnT1 in response to zinc supplementation or depletion were not consistent across studies. Leukocyte metallothionein decreased with zinc depletion (239% change from baseline, <5 mg Zn/d, n = 2 studies) and increased with zinc supplementation in a dose-dependent manner (35%, 15-22 mg Zn/d, n = 7 studies; 267%, 50 mg Zn/d, n = 2 studies) and at the earliest time points measured; however, no change or delayed response was observed in metallothionein in erythrocytes. A greater percentage of studies demonstrated that metallothionein in leukocyte subtypes was a more reliable (100%, n = 12; 69%, n = 16) and responsive (92%, n = 12; 82%, n = 11) indicator of zinc exposure than was plasma zinc, respectively. In conclusion, current evidence indicates that metallothionein in leukocyte subtypes may be a component in determining zinc status. C1 [Hennigar, Stephen R.; Kelley, Alyssa M.; McClung, James P.] US Army, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. RP McClung, JP (reprint author), US Army, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. EM james.p.mcclung8.civ@mail.mil FU US Army Military Research and Material Command FX Supported in part by the US Army Military Research and Material Command and appointment to the US Army Research Institute of Environmental Medicine administered by the Oak Ridge Institute for Science and Education (to SRH and AMK) through an interagency agreement between the US Department of Energy and the US Army Medical Research and Material Command. NR 43 TC 1 Z9 1 U1 8 U2 11 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 2161-8313 EI 2156-5376 J9 ADV NUTR JI Adv. Nutr. PD JUL PY 2016 VL 7 IS 4 BP 735 EP 746 DI 10.3945/an.116.012518 PG 12 WC Nutrition & Dietetics SC Nutrition & Dietetics GA DS1FU UT WOS:000380342000010 PM 27422508 ER PT J AU Dwyer, JT Rubin, KH Fritsche, KL Psota, TL Liska, DJ Harris, WS Montain, SJ Lyle, BJ AF Dwyer, Johanna T. Rubin, Kristin H. Fritsche, Kevin L. Psota, Tricia L. Liska, Deann J. Harris, William S. Montain, Scott J. Lyle, Barbara J. TI Creating the Future of Evidence-Based Nutrition Recommendations: Case Studies from Lipid Research SO ADVANCES IN NUTRITION LA English DT Article DE dietary guidelines; fatty acids; lipid metabolism; public policy; systematic review ID CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; TRANS-FATTY-ACIDS; PLACEBO-CONTROLLED TRIAL; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; SATURATED FAT; RISK-FACTORS; INFLAMMATION; BIOMARKERS AB Strategic translational research is designed to address research gaps that answer specific guidance questions. It provides translational value with respect to nutrition guidance and regulatory and public policy. The relevance and the quality of evidence both matter in translational research. For example, design decisions regarding population, intervention, comparator, and outcome criteria affect whether or not high-quality studies are considered relevant to specific guidance questions and are therefore included as evidence within the context of systematic review frameworks used by authoritative food and health organizations. The process used in systematic reviews, developed by the USDA for its Nutrition Evidence Library, is described. An eating pattern and cardiovascular disease (CVD) evidence review is provided as an example, and factors that differentiated the studies considered relevant and included in that evidence base from those that were excluded are noted. Case studies on omega-3 (n-3) fatty acids (FAs) and industrial trans-FAs illustrate key factors vital to relevance and translational impact, including choice of a relevant population (e.g., healthy, at risk, or diseased subjects; general population or high-performance soldiers); dose and form of the intervention (e.g., food or supplement); use of relevant comparators (e.g., technically feasible and realistic); and measures for both exposure and outcomes (e.g., inflammatory markers or CVD endpoints). Specific recommendations are provided to help increase the impact of nutrition research on future dietary guidance, policy, and regulatory issues, particularly in the area of lipids. C1 [Dwyer, Johanna T.] Tufts Univ, Sch Med, Tufts Med Ctr, Boston, MA 02111 USA. [Dwyer, Johanna T.] Tufts Univ, Sch Nutr Sci & Policy, Tufts Med Ctr, Boston, MA 02111 USA. [Dwyer, Johanna T.] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA. [Rubin, Kristin H.] Kraft Heinz Co, Glenview, IL USA. [Fritsche, Kevin L.] Univ Missouri, Columbia, MO USA. [Psota, Tricia L.] USDA, Ctr Nutr & Policy Promot, Alexandria, VA USA. [Liska, Deann J.] Biofortis Res, Addison, IL USA. [Harris, William S.] OmegaQuant Analyt LLC, Sioux Falls, SD USA. [Harris, William S.] Univ South Dakota, Sch Med, Sioux Falls, SD USA. [Montain, Scott J.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. [Lyle, Barbara J.] Northwestern Univ, Sch Profess Studies, Evanston, IL 60208 USA. [Lyle, Barbara J.] Int Life Sci Inst, North Amer Branch, Washington, DC 20005 USA. RP Lyle, BJ (reprint author), Northwestern Univ, Sch Profess Studies, Evanston, IL 60208 USA.; Lyle, BJ (reprint author), Int Life Sci Inst, North Amer Branch, Washington, DC 20005 USA. EM lyleinc@att.net OI Lyle, Barbara/0000-0002-0362-7736; Fritsche, Kevin/0000-0002-0740-3801; Harris, William/0000-0003-3042-9353 FU American Society for Nutrition (ASN); International Life Sciences Institute (ILSI) North America; Technical Committee on Dietary Lipids of the North American Branch of the ILSI FX This article is a review from the symposium "Creating the Future of Evidence-Based Nutrition Recommendations, Using Lipid Research Case Studies" held 28 March 2015 at the ASN Scientific Sessions and Annual Meeting at Experimental Biology 2015 in Boston, MA. The symposium was sponsored by the American Society for Nutrition (ASN) and supported and sponsored by the International Life Sciences Institute (ILSI) North America. This is a free access article, distributed under terms (http://www.nutrition.org/publications/guidelinesand-policies/license/) that permit unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.; Supported by the Technical Committee on Dietary Lipids of the North American Branch of the ILSI. Detailed information about the group can be found at http://www.ilsi.org/NorthAmerica/Pages/DietaryLipids.aspx. ILSI North America is a public, nonprofit foundation that provides a forum to advance understanding of scientific issues related to the nutritional quality and safety of the food supply by sponsoring research programs, educational seminars and workshops, and publications. ILSI North America receives financial support primarily from its industry membership. NR 57 TC 1 Z9 1 U1 6 U2 7 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 2161-8313 EI 2156-5376 J9 ADV NUTR JI Adv. Nutr. PD JUL PY 2016 VL 7 IS 4 BP 747 EP 755 DI 10.3945/an.115.010926 PG 9 WC Nutrition & Dietetics SC Nutrition & Dietetics GA DS1FU UT WOS:000380342000011 PM 27422509 ER PT J AU Tran, DD Reckley, LK Roofe, SB AF Tran, Daniel D. Reckley, Lauren K. Roofe, Scott B. TI Asymptomatic Dorsal Tongue Mass SO JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Editorial Material C1 [Tran, Daniel D.; Reckley, Lauren K.; Roofe, Scott B.] Tripler Army Med Ctr, Dept Otolaryngol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. RP Tran, DD (reprint author), Tripler Army Med Ctr, Dept Otolaryngol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM daniel.d.tran.mil@mail.mil NR 7 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6181 EI 2168-619X J9 JAMA OTOLARYNGOL JI JAMA Otolaryngol-Head Neck Surg. PD JUL PY 2016 VL 142 IS 7 BP 705 EP 706 DI 10.1001/jamaoto.2015.3966 PG 2 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA DS0DC UT WOS:000380264600017 PM 27078041 ER PT J AU Pierce, LM Kurata, WE Matsumoto, KW Clark, ME Farmer, DM AF Pierce, Lisa M. Kurata, Wendy E. Matsumoto, Karen W. Clark, Margaret E. Farmer, Douglas M. TI Long-term epigenetic alterations in a rat model of Gulf War Illness SO NEUROTOXICOLOGY LA English DT Article DE Gulf War Illness; Epigenetics; microRNA; DNA methylation; Pyridostigmine bromide; Pesticides ID CENTRAL-NERVOUS-SYSTEM; LARGE GENE LISTS; SYNAPTIC PLASTICITY; DNA METHYLATION; HIPPOCAMPAL DYSFUNCTION; THERAPEUTIC POTENTIALS; NEURONAL EXCITABILITY; PERIPHERAL-BLOOD; DENDRITIC SPINES; NONCODING RNAS AB Gulf War Illness (GWI) is a chronic, multisymptom illness that affects 25% of the 700,000 US veterans deployed to the Persian Gulf during the 1990-1991 Gulf War. Central nervous system impairments are among the most common symptoms reported, including memory dysfunction and depression. After 25 years, the diagnosis remains elusive, useful treatments are lacking, and the cause is poorly understood, although exposures to pyridostigmine bromide (PB) and pesticides are consistently identified to be among the strongest risk factors. Epigenetic changes including altered microRNA (miRNA) expression and DNA methylation play an important role in learning, memory, and emotion regulation and have been implicated in various neurological disorders. In this study, we used an established rat model of GWI to determine whether 1) chronic alterations in miRNA expression and global DNA methylation and DNA hydroxymethylation are mechanisms involved in the pathobiology of GWI, and 2) plasma exosome small RNAs may serve as potential noninvasive biomarkers of this debilitating disease. One year after a 28-day exposure regimen of PB,' DEET (N,N-diethyl-3-methylbenzamide), permethrin, and mild stress, expression of 84 mature miRNAs and global 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) content were analyzed in the brains of GWI rats and vehicle controls by PCR array and enzyme linked immunosorbent assay, respectively. Plasma exosome RNA next-generation sequencing analysis was performed in pooled samples to discover potential noninvasive biomarkers. We found that combined exposure to low doses of GW-related chemicals and mild stress caused epigenetic modifications in the brain that persisted one year after exposure, including increased expression of miR-124-3p and miR-29b-3p in the hippocampus and regional alterations in global 5mC and 5hmC content. GW-relevant exposures also induced the differential expression of two piwi-interacting RNAs (piRNAs) in circulation (piR-007899 and piR-019162). Results from this study implicate a role for epigenetic alterations in GWI. Evaluation of the diagnostic potential of plasma exosome RNAs in veterans with GWI is warranted. Published by Elsevier B.V. C1 [Pierce, Lisa M.; Kurata, Wendy E.; Matsumoto, Karen W.] Tripler Army Med Ctr, Dept Clin Invest, 1 Jarrett White Rd, Honolulu, HI 96859 USA. [Clark, Margaret E.; Farmer, Douglas M.] Tripler Army Med Ctr, Dept Gen Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. RP Pierce, LM (reprint author), Tripler Army Med Ctr, Dept Clin Invest, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM lisa.m.pierce.civ@mail.mil FU Department of Defense Congressionally Directed Medical Research Programs (CDMRP) Gulf War Illness Research Program (GWIRP) [FMBB100528621 (GW120033)] FX This work was funded by Department of Defense Congressionally Directed Medical Research Programs (CDMRP) Gulf War Illness Research Program (GWIRP) grant award FMBB100528621 (GW120033) to LMP. CDMRP had no involvement in the study design, collection, analysis and interpretation of data, or writing of the manuscript. NR 92 TC 0 Z9 0 U1 3 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0161-813X EI 1872-9711 J9 NEUROTOXICOLOGY JI Neurotoxicology PD JUL PY 2016 VL 55 BP 20 EP 32 DI 10.1016/j.neuro.2016.05.007 PG 13 WC Neurosciences; Pharmacology & Pharmacy; Toxicology SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology GA DS1UI UT WOS:000380385800004 PM 27179617 ER PT J AU Ouyang, RW Kaplan, LM Toniolo, A Srivastava, M Norman, TJ AF Ouyang, Robin Wentao Kaplan, Lance M. Toniolo, Alice Srivastava, Mani Norman, Timothy J. TI Aggregating Crowdsourced Quantitative Claims: Additive and Multiplicative Models SO IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING LA English DT Article DE Crowdsourcing; truth discovery; quantitative task; probabilistic graphical model AB Truth discovery is an important technique for enabling reliable crowdsourcing applications. It aims to automatically discover the truths from possibly conflicting crowdsourced claims. Most existing truth discovery approaches focus on categorical applications, such as image classification. They use the accuracy, i.e., rate of exactly correct claims, to capture the reliability of participants. As a consequence, they are not effective for truth discovery in quantitative applications, such as percentage annotation and object counting, where similarity rather than exact matching between crowdsourced claims and latent truths should be considered. In this paper, we propose two unsupervised Quantitative Truth Finders (QTFs) for truth discovery in quantitative crowdsourcing applications. One QTF explores an additive model and the other explores a multiplicative model to capture different relationships between crowdsourced claims and latent truths in different classes of quantitative tasks. These QTFs naturally incorporate the similarity between variables. Moreover, they use the bias and the confidence instead of the accuracy to capture participants' abilities in quantity estimation. These QTFs are thus capable of accurately discovering quantitative truths in particular domains. Through extensive experiments, we demonstrate that these QTFs outperform other state-of-the-art approaches for truth discovery in quantitative crowdsourcing applications and they are also quite efficient. C1 [Ouyang, Robin Wentao] Chinese Acad Sci, Inst Comp Technol, CAS Key Lab Network Data Sci & Technol, Beijing, Peoples R China. [Kaplan, Lance M.] US Army Res Lab, Networked Sensing & Fus Branch, Adelphi, MD 20783 USA. [Toniolo, Alice; Norman, Timothy J.] Univ Aberdeen, Dept Comp Sci, Aberdeen, Scotland. [Srivastava, Mani] Univ Calif Los Angeles, Dept Elect Engn, Los Angeles, CA 90095 USA. [Srivastava, Mani] Univ Calif Los Angeles, Dept Comp Sci, Los Angeles, CA 90095 USA. RP Ouyang, RW (reprint author), Chinese Acad Sci, Inst Comp Technol, CAS Key Lab Network Data Sci & Technol, Beijing, Peoples R China. EM ouyangwt@ict.ac.cn; lance.m.kaplan@us.army.mil; a.toniolo@abdn.ac.uk; mbs@ucla.edu; t.j.norman@abdn.ac.uk FU U.S. ARL; U.K. Ministry of Defense [W911NF-06-3-0001]; U.S. NSF [CNS-1213140] FX This work was supported in part by the U.S. ARL and U.K. Ministry of Defense under Agreement Number W911NF-06-3-0001, and by the U.S. NSF under award CNS-1213140. Any opinions, findings and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views or represent the official policies of the NSF, the U.S. ARL, the U.S. Government, the U.K. Ministry of Defense or the U.K. Government. The U.S. and U.K. Governments are authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon. This work was done when R. W. Ouyang was a postdoc at the University of California, Los Angeles, CA. NR 38 TC 0 Z9 0 U1 4 U2 4 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1041-4347 EI 1558-2191 J9 IEEE T KNOWL DATA EN JI IEEE Trans. Knowl. Data Eng. PD JUL 1 PY 2016 VL 28 IS 7 BP 1621 EP 1634 DI 10.1109/TKDE.2016.2535383 PG 14 WC Computer Science, Artificial Intelligence; Computer Science, Information Systems; Engineering, Electrical & Electronic SC Computer Science; Engineering GA DR7ZF UT WOS:000380117500002 ER PT J AU Mittendorf, EA Ardavanis, A Symanowski, J Murray, JL Shumway, NM Litton, JK Hale, DF Perez, SA Anastasopoulou, EA Pistamaltzian, NF Ponniah, S Baxevanis, CN von Hofe, E Papamichail, M Peoples, GE AF Mittendorf, E. A. Ardavanis, A. Symanowski, J. Murray, J. L. Shumway, N. M. Litton, J. K. Hale, D. F. Perez, S. A. Anastasopoulou, E. A. Pistamaltzian, N. F. Ponniah, S. Baxevanis, C. N. von Hofe, E. Papamichail, M. Peoples, G. E. TI Primary analysis of a prospective, randomized, single-blinded phase II trial evaluating the HER2 peptide AE37 vaccine in breast cancer patients to prevent recurrence SO ANNALS OF ONCOLOGY LA English DT Article DE immunotherapy; vaccine; breast cancer; triple-negative breast cancer; HER2 ID CLINICAL-TRIAL; RESPONSES; ADJUVANT; IMMUNITY; EPITOPE AB This phase II trial of the AE37 vaccine shows no benefit in the intention-to-treat population. However, the trial confirms the vaccine to be safe and capable of stimulating an immune response. Prespecified subgroup analyses show the vaccine may reduce the recurrence rate in triple-negative breast cancer patients, suggesting an appropriate patient population for further clinical investigation.AE37 is the Ii-Key hybrid of the MHC class II peptide, AE36 (HER2 aa:776-790). Phase I studies showed AE37 administered with granulocyte macrophage colony-stimulating factor (GM-CSF) to be safe and highly immunogenic. A prospective, randomized, multicenter phase II adjuvant trial was conducted to evaluate the vaccine's efficacy. Clinically disease-free node-positive and high-risk node-negative breast cancer patients with tumors expressing any degree of HER2 [immunohistochemistry (IHC) 1-3+] were enrolled. Patients were randomized to AE37 + GM-CSF versus GM-CSF alone. Toxicity was monitored. Clinical recurrences were documented and disease-free survival (DFS) analyzed. The trial enrolled 298 patients; 153 received AE37 + GM-CSF and 145 received GM-CSF alone. The groups were well matched for clinicopathologic characteristics. Toxicities have been minimal. At the time of the primary analysis, the recurrence rate in the vaccinated group was 12.4% versus 13.8% in the control group [relative risk reduction 12%, HR 0.885, 95% confidence interval (CI) 0.472-1.659, P = 0.70]. The Kaplan-Meier estimated 5-year DFS rate was 80.8% in vaccinated versus 79.5% in control patients. In planned subset analyses of patients with IHC 1+/2+ HER2-expressing tumors, 5-year DFS was 77.2% in vaccinated patients (n = 76) versus 65.7% in control patients (n = 78) (P = 0.21). In patients with triple-negative breast cancer (HER2 IHC 1+/2+ and hormone receptor negative) DFS was 77.7% in vaccinated patients (n = 25) versus 49.0% in control patients (n = 25) (P = 0.12). The overall intention-to-treat analysis demonstrates no benefit to vaccination. However, the results confirm that the vaccine is safe and suggest that vaccination may have clinical benefit in patients with low HER2-expressing tumors, specifically TNBC. Further evaluation in a randomized trial enrolling TNBC patients is warranted. C1 [Mittendorf, E. A.] Univ Texas MD Anderson Canc Ctr, Dept Breast Surg Oncol, 1400 Pressler St,Unit 1434, Houston, TX 77030 USA. [Ardavanis, A.; Perez, S. A.; Anastasopoulou, E. A.; Pistamaltzian, N. F.; Baxevanis, C. N.; Papamichail, M.] St Savas Canc Hosp, Canc Immunol & Immunotherapy Ctr, Athens, Greece. [Symanowski, J.] Levine Canc Inst, Dept Canc Biostat, Charlotte, NC USA. [Murray, J. L.; Litton, J. K.] Univ Texas MD Anderson Canc Ctr, Dept Breast Med Oncol, Houston, TX 77030 USA. [Shumway, N. M.] Brooke Army Med Ctr, Dept Hematol Oncol, Ft Sam Houston, TX 78234 USA. [Shumway, N. M.; Ponniah, S.] Uniformed Serv Univ Hlth Sci, Dept Surg, Canc Vaccine Dev Lab, Bethesda, MD 20814 USA. [Hale, D. F.] Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. [von Hofe, E.] Antigen Express, Worcester, MA USA. [Peoples, G. E.] Canc Vaccine Dev Program, San Antonio, TX USA. [Peoples, G. E.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. RP Mittendorf, EA (reprint author), Univ Texas MD Anderson Canc Ctr, Dept Breast Surg Oncol, 1400 Pressler St,Unit 1434, Houston, TX 77030 USA. EM eamitten@mdanderson.org FU Antigen Express through Henry M. Jackson Foundation; United States Military Cancer Institute, Department of Surgery, Uniformed Services University of the Health Sciences; Department of Clinical Investigation, Walter Reed Army Medical Center; Jeanne F. Shelby Scholarship Fund; National Institutes of Health [CA016672] FX This work was primarily funded by Antigen Express through a grant to GEP via the Henry M. Jackson Foundation. Additional funding was provided by the United States Military Cancer Institute, Department of Surgery, Uniformed Services University of the Health Sciences; and the Department of Clinical Investigation, Walter Reed Army Medical Center. EAM is a R. Lee Clark Fellow of The University of Texas MD Anderson Cancer Center supported by the Jeanne F. Shelby Scholarship Fund. This study was conducted in part at the University of Texas MD Anderson Cancer Center which is supported by the National Institutes of Health Grant CA016672. Funding sources were not involved with the design or conduct of the study; in the collection, management, analysis, or interpretation of data; in the writing of the report; or in the approval or decision to submit the paper for publication. NR 20 TC 1 Z9 1 U1 6 U2 6 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0923-7534 EI 1569-8041 J9 ANN ONCOL JI Ann. Oncol. PD JUL PY 2016 VL 27 IS 7 BP 1241 EP 1248 DI 10.1093/annonc/mdw150 PG 8 WC Oncology SC Oncology GA DR2UZ UT WOS:000379760700008 PM 27029708 ER PT J AU Madsen, JD Turnage, G Getsinger, KD AF Madsen, John D. Turnage, Gray Getsinger, Kurt D. TI Efficacy of combinations of diquat or triclopyr with fluridone for control of flowering rush SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE aquatic weed; Butomus umbellatus L.; herbicide; invasive plant; management ID AQUATIC HERBICIDES; POPULATIONS; CONTACT AB Flowering rush (Butomus umbellatus L.) is an emerging invasive aquatic weed in the northern tier of the United States and southern Canada. Although several management approaches have been tested, submersed treatment with diquat is the only use pattern substantiated with field efficacy data. We tested treatments of fluridone (30 mu g L-1) with and without prior treatment with either diquat (0.19 mg L-1) or triclopyr (2 mg L-1), as well as diquat (0.19 mg L-1) or triclopyr (2 mg L-1) alone. Each treatment, and an untreated reference, was replicated in four 380-L tanks at an experimental mesocosm facility. After 8 wk, all treatments were harvested, and pots separated into above- and belowground biomass. The number of ramets and rhizome buds in each pot was also counted. Triclopyr was not effective in reducing above- or belowground biomass, or rhizome bud density. Both diquat and fluridone alone were effective in reducing above- and belowground biomass and rhizome bud density, with no statistical difference between treatments. Pretreatment with diquat did not improve the efficacy of fluridone treatments. Results suggest fluridone may be an option for flowering rush control in sites where an adequate exposure time can be maintained. C1 [Madsen, John D.] Univ Calif Davis, USDA ARS EIWRU, Dept Plant Sci, Mail Stop 4,1 Shields Ave, Davis, CA 95616 USA. [Turnage, Gray] Geosyst Res Inst, 2 Res Blvd, Mississippi State, MS 39762 USA. [Getsinger, Kurt D.] US Army, Engineer Res & Dev Ctr, CEERD E PP, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. RP Madsen, JD (reprint author), Univ Calif Davis, USDA ARS EIWRU, Dept Plant Sci, Mail Stop 4,1 Shields Ave, Davis, CA 95616 USA. EM jmadsen@ucdavis.edu OI Turnage, Gray/0000-0001-6337-6329 FU Aquatic Ecosystem Restoration Foundation; U.S. Army Corps of Engineers Aquatic Plant Control Research Program FX Research was supported by the Aquatic Ecosystem Restoration Foundation and the U.S. Army Corps of Engineers Aquatic Plant Control Research Program. Reviews before submission were provided by Michael Netherland, Christopher Mudge, Guy Kyser, and Paul Pratt. Assistance was provided by Olivia Osaji, Lee Bryant, Cody Blackwell, and Logan White. Permission was granted by the Chief of Engineers to publish this information. Citation of trade names does not constitute endorsement or approval of the use of such commercial products. Mention of a manufacturer does not constitute a warranty or guarantee of the product by the U.S. Department of Agriculture or an endorsement over other products not mentioned. NR 10 TC 0 Z9 0 U1 3 U2 6 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2016 VL 54 BP 68 EP 71 PG 4 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA DR7JR UT WOS:000380076400003 ER PT J AU Hoyer, MV Netherland, MD Jones, D AF Hoyer, Mark V. Netherland, Michael D. Jones, Dean TI Littoral sediment accumulation ten years after muck removal in Lake Tohopekaliga, Florida SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE aquatic plant sedimentation; eutrophication; lake management; lake sediment ID DECOMPOSITION; DETRITUS; SHALLOW; LITTER; WATER AB In 2004 a multimillion dollar muck removal program was completed that targeted an estimated average 46 cm of muck in 1,420 ha of littoral area in Lake Tohopekaliga, FL. In 2005 sediment cores were taken from 145 sites located throughout the scraped littoral area, showing an estimated 1.6 cm of organic sediment after the removal program. To address concerns about the longevity of this management activity, sediment cores were taken again at 130 of the original sites in August 2008 and January 2015 to estimate sediment accumulation rates. From 2005 to 2015 there was a whole-lake average of 2.2 cm of organic sediment accumulated, yielding a rate of 0.22 (0.18 to 0.24, 95% confidence interval) cm yr(-1) for the decade. At that accumulation rate it would take approximately 210 yr (191 to 238, 95% confidence interval) to reach the original 46 cm of littoral muck, and these data suggest that the muck removal program will not have to be repeated for many years. Additionally, aquatic plants were identified at coring sites sampled in 2015 to determine if sediment accumulation rates were different in areas dominated by specific plant types and/or species, and no significant differences were found. C1 [Hoyer, Mark V.] Univ Florida, Sch Forest Resources & Conservat, Florida LAKEWATCH, 7922 NW 71st St, Gainesville, FL 32653 USA. [Netherland, Michael D.] US Army, Engineer Res & Dev Ctr, 7922 NW 71st St, Gainesville, FL 32653 USA. [Jones, Dean] Univ Florida, Ctr Aquat & Invas Plants, 700 Expt Stn Rd, Lake Alfred, FL 33850 USA. RP Netherland, MD (reprint author), US Army, Engineer Res & Dev Ctr, 7922 NW 71st St, Gainesville, FL 32653 USA. EM Michael.D.Netherland@usace.army.mil FU U.S. Army Engineer Aquatic Plant Control Research Program; Florida FWC; Invasive Plant Management Section FX Partial support and funding for this project was provided by the U.S. Army Engineer Aquatic Plant Control Research Program and the Florida FWC, Invasive Plant Management Section. Permission was granted by the Chief of Engineers to publish this research. NR 24 TC 0 Z9 0 U1 6 U2 6 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2016 VL 54 BP 87 EP 94 PG 8 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA DR7JR UT WOS:000380076400006 ER PT J AU Grodowitz, MJ Harms, NE Freedman, JE AF Grodowitz, Michael J. Harms, Nathan E. Freedman, Jan E. TI Use of an inexpensive chlorophyll meter to predict nitrogen levels in leaf tissues of water hyacinth (Eichhornia crassipes) SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article ID BIOLOGICAL-CONTROL; SALVINIA-MOLESTA; PLANT; HERBIVORY; GROWTH C1 [Grodowitz, Michael J.] ARS, USDA, Stoneville, MS USA. [Harms, Nathan E.; Freedman, Jan E.] US Army, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Grodowitz, MJ (reprint author), ARS, USDA, Stoneville, MS USA. EM michael.grodowitz@ars.usda.gov FU U.S. Army Aquatic Plant Control Research Program FX This research was supported by the U.S. Army Aquatic Plant Control Research Program under the direction of Linda Nelson. Permission was granted by the Chief of Engineers to publish this information. We also thank Aaron Schad, Nathan Beane, and Timothy Lewis for their critical review of the manuscript and Ms. Dian Smith for help in determining leaf nitrogen levels. NR 19 TC 0 Z9 0 U1 2 U2 2 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2016 VL 54 BP 106 EP 108 PG 3 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA DR7JR UT WOS:000380076400009 ER PT J AU Eckford, RD Barnett, DL AF Eckford, Rachel D. Barnett, Donell L. TI Comparing Paper-and-Pencil and Internet Survey Methods Conducted in a Combat-Deployed Environment SO MILITARY PSYCHOLOGY LA English DT Article DE Unit Behavioral Health Needs Assessment Survey; Internet-based research; paper-and-pencil survey; equivalence testing; deployment ID MENTAL-HEALTH PROBLEMS; PSYCHOMETRIC PROPERTIES; PSYCHOLOGICAL-RESEARCH; PRIMARY-CARE; WEB; EQUIVALENCE; PERSONALITY; SOLDIERS; TESTS; QUESTIONNAIRES AB The Unit Behavioral Health Needs Assessment Survey (UBHNAS) is a tool used to aid behavioral health providers in assessing the needs of service members of a military unit. Traditionally, the survey has been administered by paper-and-pencil; however, implementing the survey via the Internet may be a faster and easier way to administer the survey. There are, however, potential drawbacks to Internet survey administration, and previous studies comparing the 2 methods have yielded inconsistent findings. Using a between-subjects design with a combat-deployed military sample, the present study compared the 2 survey administration methods. Specifically, we assessed comparability for (a) psychological constructs, (b) auxiliary measures (such as completion time, frequency of missing data, and length of written comments), and (c) ratings and perceptions of the UBHNAS, and preference in methodology. The method of survey administration did not predict differences in the psychological outcome variables. However, participants in the paper-and-pencil condition reported higher rates of comfort answering questions, belief that responses would remain anonymous, and frankness and honesty in answering questions. Nevertheless, participants in both conditions preferred to take the survey via the Internet as opposed to paper-and-pencil in the future. Finally, participants in the Internet condition completed the survey faster and tended to write longer comments, although in terms of the comments being informative, there was no difference between the groups. Based on our findings, we recommend the use of the Internet for administering the UBHNAS; however, we caution that there may be tradeoffs regarding concerns about comfort, honesty, and anonymity. C1 [Eckford, Rachel D.] Walter Reed Army Inst Res, US Army Med Res Unit Europe, Sembach, Germany. [Barnett, Donell L.] US Army 44th Med Brigade, Med Detachment 528, Ft Bragg, NC USA. [Barnett, Donell L.] Army Publ Hlth Ctr PROV, Aberdeen, MD USA. RP Eckford, RD (reprint author), 48 Hebelstr, D-68789 St Leon Rot, Germany. EM Rachel.Eckford@gmail.com NR 57 TC 0 Z9 0 U1 2 U2 2 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0899-5605 EI 1532-7876 J9 MIL PSYCHOL JI Milit. Psychol. PD JUL PY 2016 VL 28 IS 4 BP 209 EP 225 DI 10.1037/mil0000118 PG 17 WC Psychology, Multidisciplinary SC Psychology GA DR7HG UT WOS:000380070000002 ER PT J AU Williams, J Brown, JM Bray, RM Goodell, EMA Olmsted, KR Adler, AB AF Williams, Jason Brown, Janice M. Bray, Robert M. Goodell, Erin M. Anderson Olmsted, Kristine Rae Adler, Amy B. TI Unit Cohesion, Resilience, and Mental Health of Soldiers in Basic Combat Training SO MILITARY PSYCHOLOGY LA English DT Article DE cohesion; resilience; Basic Combat Training ID SCALE CD-RISC; PSYCHOMETRIC PROPERTIES; STATES; RANDOMIZATION; PREDICTORS; PLATOON; STRESS AB Military unit cohesion has been shown to correlate with physical and psychological outcomes. However, little is known about the development of cohesion in the early days of military service during Basic Combat Training (BCT) and how it relates to positive support and the negative stressors of training. The current study assessed the development of unit cohesion across the 10-week BCT period (N = 1,939), and the relation of cohesion to stress, resilience, mental health measures, and BCT outcomes (graduation, passing the Army Physical Fitness Test, and final Basic Rifle Marksmanship scores). The sample was primarily male (62%), under age 25 (88%), and unmarried (88%). All putative mediators showed significant change over time. Unit cohesion increased over time (slope 0.22; p < .001), and these increases were associated with decreases in psychological distress (p < .001), sleep problems (p < .001), and tolerance of BCT stressors (p < .001), as well as increases in resilience (p < .001), confidence managing stress reactions (p < .001), and positive states of mind (p < .001). Unit cohesion was indirectly associated with successful graduation and passing the Army Physical Fitness Test through cohesion-related improvement in psychological distress, resilience, and confidence managing reactions to stress. Sleep problems also mediated BCT graduation. Cohesion effects on the Basic Rifle Marksmanship scores were mediated by psychological distress and tolerance of BCT stressors only. These results suggest that unit cohesion may play a key role in the development of psychological health among new soldiers. C1 [Williams, Jason; Brown, Janice M.; Bray, Robert M.; Olmsted, Kristine Rae] RTI Int, 3040 Cornwallis Rd, Res Triangle Pk, NC 27709 USA. [Goodell, Erin M. Anderson] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mental Hlth, Baltimore, MD USA. [Adler, Amy B.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Williams, J (reprint author), RTI Int, 3040 Cornwallis Rd, Res Triangle Pk, NC 27709 USA. EM jawilliams@rti.org FU Walter Reed Army Institute of Research (WRAIR) [W81XWH-09-P-0548]; RTI International; National Institute on Drug Abuse (NIDA) [T32-DA007293] FX This research was supported by Contract Number W81XWH-09-P-0548 to RTI International from the Walter Reed Army Institute of Research (WRAIR), internal funds from RTI International, and National Institute on Drug Abuse (NIDA) training grant T32-DA007293. The views, opinions, and findings contained in this report are those of the authors and should not be construed as an official Army position, policy, or decision, unless so designated by other official documentation. NR 32 TC 1 Z9 1 U1 6 U2 6 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0899-5605 EI 1532-7876 J9 MIL PSYCHOL JI Milit. Psychol. PD JUL PY 2016 VL 28 IS 4 BP 241 EP 250 DI 10.1037/mil0000120 PG 10 WC Psychology, Multidisciplinary SC Psychology GA DR7HG UT WOS:000380070000004 ER PT J AU Liao, DH Dogaru, T AF Liao, DaHan Dogaru, Traian TI Full-Wave Scattering and Imaging Characterization of Realistic Trees for FOPEN Sensing SO IEEE GEOSCIENCE AND REMOTE SENSING LETTERS LA English DT Article DE Airborne radar; electromagnetic scattering; foliage penetration (FOPEN) radar imaging; full-wave solver; tree scattering ID IMAGES; MODELS; RADAR AB The electromagnetic characterization of realistic tree structures is performed to facilitate the development of low-frequency (P-band) foliage penetration radars. The full-wave approach employs a parallelized 3-D finite-difference time-domain algorithm deployed on high-performance computing systems to simulate the far-field scattering responses from scenes. The backscattering behaviors of a single tree are first considered as a function of frequency, polarization, signal incidence angle, and structural fidelity, and then, large-scale simulations are carried out to examine the responses of a forest stand in both the frequency and imaging domains. The results featured are from the first phase of an ongoing study to investigate the feasibility of applying large-scale electromagnetic simulations to support airborne-based sensing of obscured ground targets. C1 [Liao, DaHan; Dogaru, Traian] US Army Res Lab, Adelphi, MD 20783 USA. RP Liao, DH (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM dahan.liao.civ@mail.mil NR 19 TC 0 Z9 0 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1545-598X EI 1558-0571 J9 IEEE GEOSCI REMOTE S JI IEEE Geosci. Remote Sens. Lett. PD JUL PY 2016 VL 13 IS 7 BP 957 EP 961 DI 10.1109/LGRS.2016.2555478 PG 5 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA DR2EU UT WOS:000379718600016 ER PT J AU Hoch, MC Hoch, JM Houston, MN AF Hoch, Matthew C. Hoch, Johanna M. Houston, Megan N. TI Development of the Quick-FAAM: A Preliminary Shortened Version of the Foot and Ankle Ability Measure for Chronic Ankle Instability SO INTERNATIONAL JOURNAL OF ATHLETIC THERAPY & TRAINING LA English DT Article ID PARADIGM; VALIDITY; TESTS AB The study objective was to develop a shortened version of the Foot and Ankle Ability Measure (FAAM) for individuals with chronic ankle instability (CAI). Forty individuals with CAI completed the FAAM Activities of Daily Living and Sport subscales and the Short Form-12. Analyses were completed for item reduction followed by dimensionality, coverage redundancy, and internal consistency of a reduced-item instrument. Validity was examined through correlations with the original FAAM and Short Form-12. A 12-item FAAM was created which demonstrated strong internal consistency and convergent/divergent validity. The Quick-FAAM may provide an alternative patient-reported outcome for CAI which requires less administration time. C1 [Hoch, Matthew C.; Hoch, Johanna M.] Old Dominion Univ, Sch Phys Therapy & Athlet Training, Norfolk, VA USA. [Houston, Megan N.] Keller Army Community Hosp, West Point, NY USA. RP Hoch, MC (reprint author), Old Dominion Univ, Sch Phys Therapy & Athlet Training, Norfolk, VA USA. NR 21 TC 0 Z9 0 U1 1 U2 1 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 2157-7277 EI 2157-7285 J9 INT J ATHL THER TRAI JI Int. J. Athl. Ther. Train. PD JUL PY 2016 VL 21 IS 4 BP 45 EP 49 DI 10.1123/ijatt.2016-0002 PG 5 WC Sport Sciences SC Sport Sciences GA DR5VX UT WOS:000379971600008 ER PT J AU Buehner, M Pamplin, J Studer, L Hughes, RL King, BT Graybill, JC Chung, KK AF Buehner, Michelle Pamplin, Jeremy Studer, Lynette Hughes, Rhome L. King, Booker T. Graybill, John C. Chung, Kevin K. TI Oxalate Nephropathy After Continuous Infusion of High-Dose Vitamin C as an Adjunct to Burn Resuscitation SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID ACUTE-RENAL-FAILURE; ASCORBIC-ACID; FLUID VOLUME; ANTIOXIDANT THERAPY; DELAYED INITIATION; XANTHINE-OXIDASE; THERMAL-INJURY; REQUIREMENTS; REDUCTION; OXALOSIS AB Fluid resuscitation is the foundation of management in burn patients and is the topic of considerable research. One adjunct in burn resuscitation is continuous, high-dose vitamin C (ascorbic acid) infusion, which may reduce fluid requirements and thus decrease the risk for over resuscitation. Research in preclinical studies and clinical trials has shown continuous infusions of high-dose vitamin C to be beneficial with decrease in resuscitative volumes and limited adverse effects. However, high-dose and low-dose vitamin C supplementation has been shown to cause secondary calcium oxalate nephropathy, worsen acute kidney injury, and delay renal recovery in non-burn patients. To the best of our knowledge, the authors present the first case series in burn patients in whom calcium oxalate nephropathy has been identified after high-dose vitamin C therapy. C1 [Buehner, Michelle] San Antonio Mil Med Ctr, Dept Surg, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. [Pamplin, Jeremy; King, Booker T.; Graybill, John C.; Chung, Kevin K.] US Army, Inst Surg Res, JBSA, Ft Sam Houston, TX USA. [Studer, Lynette; Hughes, Rhome L.] San Antonio Mil Med Ctr, Dept Pathol, Ft Sam Houston, TX USA. [Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Dept Med, Room A3060, Bethesda, MD 20814 USA. RP Buehner, M (reprint author), San Antonio Mil Med Ctr, Dept Surg, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM michelle.f.buehner.mil@mail.mil NR 39 TC 2 Z9 2 U1 5 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1559-047X EI 1559-0488 J9 J BURN CARE RES JI J. Burn Care Res. PD JUL-AUG PY 2016 VL 37 IS 4 BP E374 EP E379 DI 10.1097/BCR.0000000000000233 PG 6 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA DR1MM UT WOS:000379669600010 PM 25812044 ER PT J AU Haile, MA Hall, AJ Yoo, JH Coatney, MD Myers, OJ AF Haile, Mulugeta A. Hall, Asha J. Yoo, Jin Hyeong Coatney, Michael D. Myers, Oliver J. TI Detection of damage precursors with embedded magnetostrictive particles SO JOURNAL OF INTELLIGENT MATERIAL SYSTEMS AND STRUCTURES LA English DT Article DE Terfenol-D; composite fatigue; crazes; microcracks ID ACOUSTIC-EMISSION; CRACK-GROWTH; COMPOSITES; TRANSDUCERS; SENSOR; MODEL AB Polymer composites subjected to cyclic loading would exhibit damage precursors, such as crazes and microcracks, during the first few load cycles. However, damage precursors are not readily detectable with existing sensing techniques, and as such current service life prediction methods depend on macroscopic damage measures. For critical airframe structures, information on macroscopic damage does not provide adequate warning time for corrective actions. This article explores the feasibility of embedding particulate magnetostrictive particles for sensing damage precursors during the early stage of fatigue damage. The sensing is based on the notion that magnetostrictive particles undergo irreversible changes in magnetization intensity when subjected to cyclic loading, and that this change can be captured with an induction coil sensor. In the sequel, Terfenol-D particles are embedded between layers of pre-preg AS4/3501-6 material system. The specimen is then subjected to fatigue loading while monitoring the change in the strength of the magnetic flux density using pickup coil. Results show that the embedded system exhibits a change in magnetic state, in tens to hundreds of millivolts of pickup coil, starting from the first few load cycles. Scanning electron microscopy and acoustic emission data were used to validate the observed results. C1 [Haile, Mulugeta A.; Hall, Asha J.; Yoo, Jin Hyeong; Coatney, Michael D.] US Army Res Lab, Mech Div, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA. [Myers, Oliver J.] Clemson Univ, Dept Mech Engn, Clemson, SC USA. RP Haile, MA (reprint author), US Army Res Lab, Mech Div, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA. EM mulugeta.a.haile.civ@mail.mil NR 34 TC 1 Z9 1 U1 6 U2 7 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1045-389X EI 1530-8138 J9 J INTEL MAT SYST STR JI J. Intell. Mater. Syst. Struct. PD JUL PY 2016 VL 27 IS 12 BP 1567 EP 1576 DI 10.1177/1045389X15596628 PG 10 WC Materials Science, Multidisciplinary SC Materials Science GA DR5SL UT WOS:000379962600001 ER PT J AU Song, SJA Wei, JM Buttram, J Tolisano, AM Chang, ET Yung-Chuan, S Certal, V Camacho, M AF Song, Sungjin A. Wei, Justin M. Buttram, Jonathan Tolisano, Anthony M. Chang, Edward T. Yung-Chuan, Stanley Certal, Victor Camacho, Macario TI Hyoid Surgery Alone for Obstructive Sleep Apnea: A Systematic Review and Meta-analysis SO LARYNGOSCOPE LA English DT Review DE Obstructive sleep apnea; hyoid surgery; systematic review; meta-analysis ID HYPOPHARYNGEAL SURGERY; MANDIBULAR OSTEOTOMY; MYOTOMY-SUSPENSION; ADVANCEMENT; AIRWAY; BONE AB Objectives/Hypothesis: The primary objective was to determine if sleep study variables (e.g., apnea-hypopnea index [AHI] and lowest oxygen saturation) and quantitative sleepiness data improve following isolated hyoid surgery for obstructive sleep apnea (OSA). Study Design: Systematic review and meta-analysis. Methods: Nine databases, including PubMed, were searched through September 5, 2015. Results: Four hundred ninety-eight studies were screened, 64 were reviewed, and nine studies met inclusion criteria. A total of 101 patients were identified who underwent hyoid surgery alone for treatment of OSA. Subanalyses were performed for: 1) type of surgery, 2) primary versus secondary hyoid surgery, 3) positional versus nonpositional OSA, 4) age, and 5) body mass index. In patients undergoing isolated hyoid surgery, the AHI decreased from a mean 6 standard deviation of 37.3 +/- 21.1 (95% confidence interval [CI]: 33.1, 41.5) to 23.0 +/- 18.6 (95% CI: 19.3, 26.7) events/hour, which correspond to a 38.3% reduction (P < .0001). AHI reduced by 38.3% for hyoid myotomy with suspension, by 50.7% for hyothyroidopexy, and by 7.1% for hyoid expansion. The Epworth Sleepiness Scale decreased by 3.2 points from 10.3 +/- 4.9 (95% CI: 8.8, 11.8) to 7.1 +/- 4.2 (95% CI: 5.8, 8.4; P = .0027). Conclusions: Isolated hyoid surgery has reduced OSA severity and improved sleepiness in adults. Hyothyroidopexy provided a 50.7% reduction in AHI, followed by hyoid myotomy with suspension (38.3% reduction in AHI) and hyoid expansion (7.1% reduction in AHI). The current literature lacks high-quality evidence with regard to hyoid surgery, and additional studies are needed to further elucidate the effect of hyoid surgery in OSA. C1 [Song, Sungjin A.; Wei, Justin M.; Tolisano, Anthony M.; Chang, Edward T.; Camacho, Macario] Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Div Sleep Surg & Med, Honolulu, HI 96859 USA. [Buttram, Jonathan] Med Univ South Carolina, Coll Med, Charleston, SC USA. [Yung-Chuan, Stanley] Stanford Hosp & Clin, Div Sleep Surg & Med, Dept Otolaryngol Head & Neck Surg, Stanford, CA USA. [Certal, Victor] Hosp CUF, Sleep Med Ctr, Dept Otorhinolaryngol, Oporto, Portugal. [Certal, Victor] Univ Porto, Ctr Res Hlth Technol & Informat Syst, Oporto, Portugal. [Camacho, Macario] Stanford Hosp & Clin, Sleep Med Div, Dept Psychiat & Behav Sci, Stanford, CA USA. RP Song, SJA (reprint author), Tripler Army Med Ctr, Div Sleep Surg & Med, Otolaryngol Head & Neck Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM drcamachoent@yahoo.com NR 30 TC 2 Z9 2 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0023-852X EI 1531-4995 J9 LARYNGOSCOPE JI Laryngoscope PD JUL PY 2016 VL 126 IS 7 BP 1702 EP 1708 DI 10.1002/lary.25847 PG 7 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA DR6AP UT WOS:000379983800045 PM 26801005 ER PT J AU Camacho, M Song, SJA Cable, BB AF Camacho, Macario Song, Sungjin A. Cable, Benjamin B. TI In Response to Supraglottoplasty for Laryngomalacia With Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis SO LARYNGOSCOPE LA English DT Letter C1 [Camacho, Macario; Song, Sungjin A.; Cable, Benjamin B.] Tripler Army Med Ctr, Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA. RP Camacho, M (reprint author), Tripler Army Med Ctr, Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0023-852X EI 1531-4995 J9 LARYNGOSCOPE JI Laryngoscope PD JUL PY 2016 VL 126 IS 7 BP E264 EP E264 DI 10.1002/lary.25949 PG 1 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA DR6AP UT WOS:000379983800008 PM 26925548 ER PT J AU Lall, P Zhang, D Yadav, V Locker, D AF Lall, Pradeep Zhang, Di Yadav, Vikas Locker, David TI High strain rate constitutive behavior of SAC105 and SAC305 leadfree solder during operation at high temperature SO MICROELECTRONICS RELIABILITY LA English DT Article; Proceedings Paper CT 16th International Conference on Thermal, Mechanical and Multi-Physics Simulation and Experiments in Micro-Electronics and Micro-Systems (EuroSimE) CY APR 19-22, 2015 CL Budapest, HUNGARY DE Solder joints; High strain rate; Constitutive behavior; Leadfree; Life prediction ID JOINTS; MODEL AB Industry migration to leadfree solders has resulted in a proliferation of a wide variety of solder alloy compositions. The most popular amongst these are the Sn-Ag-Cu family of alloys like SAC105 and SAC305. Electronics subjected to shock and vibration may experience strain rates of 1-100/s. Electronic product may often be exposed to high temperature during storage, operation and handling in addition to high strain rate transient dynamic loads during drop-impact, shock and vibration. Properties of leadfree solder alloys at high strain rates at low and high temperatures experienced by the solder joint during typical mechanical shock events are scarce. Previous studies have showed the effect of high strain rates and thermal aging on the mechanical properties of leadfree alloys including elastic modulus and the ultimate tensile strength. The ANAND viscoplastic constitutive model has been widely used to describe the inelastic deformation behavior of solders in electronic components. In this study, SAC105 and SAC305 leadfree alloys have been tested at strain rates of 10, 35, 50 and 75/s at various operating temperatures of 50 degrees C, 75 degrees C,100 degrees C and 125 degrees C. Full-field strain in the specimen have been measured using high speed imaging at frame rates up to 75,000 fps in combination with digital image correlation. The cross-head velocity has been measured prior-to, during, and after deformation to ensure the constancy of cross-head velocity. Stress-strain curves have been plotted over a wide range of strain rates and temperatures. Experimental data for the pristine specimen has been fit to the ANAND's viscoplastic model. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Lall, Pradeep; Zhang, Di; Yadav, Vikas] Auburn Univ, Dept Mech Engn, Elect Res Ctr NSF CAVE3, Auburn, AL 36849 USA. [Lall, Pradeep] USA, AMRDEC, Huntsville, AL USA. RP Lall, P (reprint author), Auburn Univ, Dept Mech Engn, Elect Res Ctr NSF CAVE3, Auburn, AL 36849 USA. EM lall@auburn.edu NR 23 TC 1 Z9 1 U1 11 U2 15 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0026-2714 J9 MICROELECTRON RELIAB JI Microelectron. Reliab. PD JUL PY 2016 VL 62 BP 4 EP 17 DI 10.1016/j.microrel.2016.03.014 PG 14 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA DR1ZY UT WOS:000379705600002 ER PT J AU Ndahimana, JD Riedel, DJ Mwumvaneza, M Sebuhoro, D Uwimbabazi, JC Kubwimana, M Mugabo, J Mulindabigwi, A Kirk, C Kanters, S Forrest, JI Jagodzinski, LL Peel, SA Ribakare, M Redfield, RR Nsanzimana, S AF Ndahimana, Jean d'Amour Riedel, David J. Mwumvaneza, Mutagoma Sebuhoro, Dieudone Uwimbabazi, Jean Claude Kubwimana, Marthe Mugabo, Jules Mulindabigwi, Augustin Kirk, Catherine Kanters, Steve Forrest, Jamie I. Jagodzinski, Linda L. Peel, Sheila A. Ribakare, Muhayimpundu Redfield, Robert R. Nsanzimana, Sabin TI Drug resistance mutations after the first 12 months on antiretroviral therapy and determinants of virological failure in Rwanda SO TROPICAL MEDICINE & INTERNATIONAL HEALTH LA English DT Article DE HIV; drug resistance; tenofovir; Rwanda; viral failure ID SOUTH-AFRICA; LIFE EXPECTANCY; HIV; PREVALENCE; UGANDA; INITIATION; COUNTRIES; REGIMEN; CLINICS; VIREMIA AB ObjectiveTo evaluate HIV drug resistance (HIVDR) and determinants of virological failure in a large cohort of patients receiving first-line tenofovir-based antiretroviral therapy (ART) regimens. MethodsA nationwide retrospective cohort from 42 health facilities was assessed for virological failure and development of HIVDR mutations. Data were collected at ART initiation and at 12 months of ART on patients with available HIV-1 viral load (VL) and ART adherence measurements. HIV resistance genotyping was performed on patients with VL 1000 copies/ml. Multiple logistic regression was used to determine factors associated with treatment failure. ResultsOf 828 patients, 66% were women, and the median age was 37 years. Of the 597 patients from whom blood samples were collected, 86.9% were virologically suppressed, while 11.9% were not. Virological failure was strongly associated with age <25 years (adjusted odds ratio [aOR]: 6.4; 95% confidence interval [CI]: 3.2-12.9), low adherence (aOR: 2.87; 95% CI: 1.5-5.0) and baseline CD4 counts <200 cells/l (aOR 3.4; 95% CI: 1.9-6.2). Overall, 9.1% of all patients on ART had drug resistance mutations after 1 year of ART; 27% of the patients who failed treatment had no evidence of HIVDR mutations. HIVDR mutations were not observed in patients on the recommended second-line ART regimen in Rwanda. ConclusionsThe last step of the UNAIDS 90-90-90 target appears within grasp, with some viral failures still due to non-adherence. Nonetheless, youth and late initiators are at higher risk of virological failure. Youth-focused programmes could help prevent further drug HIVDR development. C1 [Ndahimana, Jean d'Amour; Mwumvaneza, Mutagoma; Sebuhoro, Dieudone; Kubwimana, Marthe; Mulindabigwi, Augustin; Ribakare, Muhayimpundu; Nsanzimana, Sabin] Rwanda Biomed Ctr, Div HIV AIDS, Kigali, Rwanda. [Riedel, David J.; Redfield, Robert R.] Univ Maryland, Inst Human Virol, Baltimore, MD 21201 USA. [Riedel, David J.; Redfield, Robert R.] Univ Maryland, Div Infect Dis, Baltimore, MD 21201 USA. [Uwimbabazi, Jean Claude] Rwanda Biomed Ctr Reference Lab, Kigali, Rwanda. [Mugabo, Jules] World Hlth Org, Kigali, Rwanda. [Kirk, Catherine] Partners Hlth Inshuti Mu Buzima, Kigali, Rwanda. [Kanters, Steve; Forrest, Jamie I.] Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC, Canada. [Kanters, Steve; Forrest, Jamie I.] Global Evaluat Sci, Vancouver, BC, Canada. [Jagodzinski, Linda L.; Peel, Sheila A.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Nsanzimana, Sabin] Univ Basel, Swiss Trop & Publ Hlth Inst, Basel, Switzerland. [Nsanzimana, Sabin] Basel Inst Clin Epidemiol & Biostat, Basel, Switzerland. RP Nsanzimana, S (reprint author), Rwanda Biomed Ctr, Inst HIV Dis Prevent & Control, Kigali, Rwanda. EM nsabinco@gmail.com FU WHO; Walter Reed Army Institute of Research; Rwanda Biomedical Center FX This study was financially supported by WHO and by the Walter Reed Army Institute of Research, where the HIV-1 resistance genotype tests were conducted. The authors are grateful to the participants in this study, the healthcare providers who invited patients and arranged the place for interview and the Rwanda Biomedical Center for facilitating all financial and administrative procedures. The views and opinions expressed are those of the authors and should not be construed as official or representing the positions of the Department of Army or Defense. The HIV resistance genotype testing was supported by a cooperative agreement between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense. NR 27 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1360-2276 EI 1365-3156 J9 TROP MED INT HEALTH JI Trop. Med. Int. Health PD JUL PY 2016 VL 21 IS 7 BP 928 EP 935 DI 10.1111/tmi.12717 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA DR3VQ UT WOS:000379831100011 PM 27125473 ER PT J AU Peterson, JA AF Peterson, James A. TI SHAREABLE RESOURCE Ten Engaging Facts About Heart Attacks SO ACSMS HEALTH & FITNESS JOURNAL LA English DT Editorial Material C1 [Peterson, James A.] StairMaster, Sports Med, West Point, NY USA. [Peterson, James A.] US Mil Acad, Phys Educ, West Point, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1091-5397 EI 1536-593X J9 ACSMS HEALTH FIT J JI ACSMS Health Fit. J. PD JUL-AUG PY 2016 VL 20 IS 4 BP 44 EP 44 PG 1 WC Sport Sciences SC Sport Sciences GA DR0RR UT WOS:000379615100012 ER PT J AU Wu, AW Wansom, T Huang, IC CoFrancesco, J Conant, MA Sarwer, DB AF Wu, Albert W. Wansom, Tanyaporn Huang, I-Chan CoFrancesco, Joseph, Jr. Conant, Marcus A. Sarwer, David B. TI The Facial Appearance Inventory: Development and Preliminary Evidence for Reliability and Validity in People with HIV and Lipoatrophy SO AESTHETIC SURGERY JOURNAL LA English DT Article ID QUALITY-OF-LIFE; HUMAN-IMMUNODEFICIENCY-VIRUS; ACTIVE ANTIRETROVIRAL THERAPY; INJECTION-DRUG USE; L-LACTIC ACID; MEDICAL OUTCOMES; INFECTED MEN; PROTEASE INHIBITORS; FAT REDISTRIBUTION; HEALTH SURVEY AB Facial lipoatrophy is common in people on antiretroviral (ARV) regimens for HIV/AIDS and can impair health-related quality of life. We developed the Facial Appearance Inventory (FAI) to measure the impact of ARV-associated facial lipoatrophy. Qualitative methods were used to identify key concerns of people with facial lipoatrophy. The major concerns were used to identify 24 items for the FAI. The FAI was administered to a cross-sectional sample of 96 people with HIV and facial lipoatrophy and compared to the established Assessment of Body Change Distress (ABCD) and MOS-HIV questionnaires. Mean age was 48.8 years, 87.5% were men, 69.8% were Caucasian, and 60% had some college education. Mean CD4 count was 435 cells/mm(3). There were few missing data, and the summary score showed no floor or ceiling effects, with a mean (SD) of 25.6 (17.9). Cronbach's alpha for the scale was 0.98. FAI items satisfied criteria for convergent and discriminant construct validity. FAI items were more strongly correlated with mental health domains (R = 0.33) than with physical health domains (R = 0.26) on the MOS-HIV. Patients with greater severity of lipoatrophy had significantly worse scores than those with less severity (James 3-4, vs. James 0-2). There were no significant differences for FAI scores by age group, income group, CD4 cell count, or HIV viral load group. Those with less education and those with darker skin types reported less impairment (P < .05). The 24-item FAI shows evidence for reliability, validity, and usefulness as a measure of the impact of facial lipoatrophy. C1 [Wu, Albert W.] Johns Hopkins Univ, Johns Hopkins Bloomberg Sch Publ Hlth, Hlth Policy & Management, Baltimore, MD USA. [Wansom, Tanyaporn] Armed Forces Res Inst Med Sci, Dept Retrovirol, Henry M Jackson Fdn, Bangkok, Thailand. [Huang, I-Chan] St Jude Childrens Res Hosp, Dept Epidemiol & Canc Control Outcomes & Policy, 332 N Lauderdale St, Memphis, TN 38105 USA. [CoFrancesco, Joseph, Jr.] Johns Hopkins Sch Med, Med, Baltimore, MD USA. [Conant, Marcus A.] Univ Calif San Francisco, San Francisco Sch Med, Dermatol, San Francisco, CA 94143 USA. [Conant, Marcus A.] Univ Calif San Francisco, San Francisco Sch Med, San Francisco, CA 94143 USA. [Sarwer, David B.] Temple Univ, Res, Philadelphia, PA 19122 USA. [Sarwer, David B.] Temple Univ, Coll Publ Hlth, Ctr Obes Res & Educ, Philadelphia, PA 19122 USA. RP Wu, AW (reprint author), Johns Hopkins Univ, Ctr Hlth Serv & Outcomes Res, 624 N Broadway,Room 653, Baltimore, MD 21205 USA. EM awu@jhu.edu FU Valeant Pharmaceutical International (West Laval, Quebec, Canada) FX This study was funded in part by an unrestricted research grant from Dermik Laboratories, now a part of Valeant Pharmaceutical International (West Laval, Quebec, Canada). Funding was used for research assistant salary, patient incentives, printing, and data entry costs. NR 43 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1090-820X EI 1527-330X J9 AESTHET SURG J JI Aesthet. Surg. J. PD JUL-AUG PY 2016 VL 36 IS 7 BP 842 EP 851 DI 10.1093/asj/sjw010 PG 10 WC Surgery SC Surgery GA DR1YK UT WOS:000379700600024 PM 26931304 ER PT J AU Shah, AR Wenke, JC Agrawal, CM AF Shah, Amita R. Wenke, Joseph C. Agrawal, Chandra Mauli TI Manipulation of Human Primary Endothelial Cell and Osteoblast Coculture Ratios to Augment Vasculogenesis and Mineralization SO ANNALS OF PLASTIC SURGERY LA English DT Article DE coculture; endothelial cells; osteoblast; human primary cells; bone regeneration; vasculogenesis ID IN-VITRO ANGIOGENESIS; GENE-EXPRESSION; VEGF; VASCULARIZATION; DIFFERENTIATION; CROSSTALK; BLOOD; MODEL AB Tissue-engineering scaffolds are often seeded with a single type of cell, but there has been more focus on cocultures to improve angiogenesis and bone formation for craniofacial applications. Investigation of bone-derived osteoblasts (OBs) is important because of the use of bone grafts and migration of OBs from native bone into constructs in vivo and therefore, their contribution to bone formation in vivo. The limitation of primary OBs has been their inability to mineralize without osteogenic factors in vitro. Through coculture of OBs and endothelial cells (ECs) and manipulation of the coculture ratio, mineralization can be achieved without osteogenic media or additional growth factors, thus enhancing their utility for tissue-engineering applications. An optimal ratio of EC/OB for vasculogenesis and mineralization has not been determined for human primary cells. Human umbilical vein ECs were cultured with normal human primary OBs in different EC/OB ratios, namely, 10:1, 5:1, 1:1, 1:5, and 1:10 with EC and OB monocultures as controls. The number of vasculogenic networks in a collagen matrix was highest in ratios of 5:1 and 1:1. ECs lined up and formed capillary-like networks by day 10, which was not seen in the other groups. On polystyrene, cells were cocultured with ECs and OBs in direct contact (direct coculture) or separated by a transwell membrane (indirect coculture). At day 21, Alizarin Red staining showed mineralization on the 1:5 and 1:10 direct coculture ratios, with 1:5 having more mineralization nodules present than 1:10. No mineralization was seen in other direct coculture ratios or in any of the indirect coculture ratios. Alkaline phosphatase secretion was highest in the 1:5 direct coculture group. Vascular endothelial growth factor secretion from OBs was present in the 1:5 and 1:10 direct coculture ratios at all time points and inhibited after day 1 in other coculture groups. To improve vasculogenesis, cocultures of primary human ECs and OBs in ratios of 5:1 should be used, but to improve bone formation, the 1:5 direct coculture ratio results in most mineralization. C1 [Shah, Amita R.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA. [Shah, Amita R.] Univ North Carolina Chapel Hill, Div Plast & Reconstruct Surg, Chapel Hill, NC USA. [Wenke, Joseph C.] US Army Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, San Antonio, TX USA. [Agrawal, Chandra Mauli] Univ Texas San Antonio, Dept Biomed Engn, One UTSA Blvd, San Antonio, TX 78249 USA. RP Agrawal, CM (reprint author), Univ Texas San Antonio, Dept Biomed Engn, One UTSA Blvd, San Antonio, TX 78249 USA. EM Mauli.Agrawal@utsa.edu FU Department of Army [W81XWH-07-1-0717] FX Supported by Department of Army Grant W81XWH-07-1-0717. The US Army Medical Research Acquisition Activity, 820 Chandler Street, Fort Detrick, MD 21702-5014, is the awarding and administering acquisition office. NR 31 TC 0 Z9 0 U1 2 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0148-7043 EI 1536-3708 J9 ANN PLAS SURG JI Ann. Plast. Surg. PD JUL PY 2016 VL 77 IS 1 BP 122 EP 128 DI 10.1097/SAP.0000000000000318 PG 7 WC Surgery SC Surgery GA DR0SD UT WOS:000379616300024 PM 25144419 ER PT J AU Short, NJ Yuffa, AJ Videen, G Hu, SW AF Short, Nathaniel J. Yuffa, Alex J. Videen, Gorden Hu, Shuowen TI Effects of surface materials on polarimetric-thermal measurements: applications to face recognition SO APPLIED OPTICS LA English DT Article ID FACIAL RECOGNITION; EMISSIVITY; SKIN AB Materials, such as cosmetics, applied to the face can severely inhibit biometric face-recognition systems operating in the visible spectrum. These products are typically made up of materials having different spectral properties and color pigmentation that distorts the perceived shape of the face. The surface of the face emits thermal radiation, due to the living tissue beneath the surface of the skin. The emissivity of skin is approximately 0.99; in comparison, oil-and plastic-based materials, commonly found in cosmetics and face paints, have an emissivity range of 0.9-0.95 in the long-wavelength infrared part of the spectrum. Due to these properties, all three are good thermal emitters and have little impact on the heat transferred from the face. Polarimetric-thermal imaging provides additional details of the face and is also dependent upon the thermal radiation from the face. In this paper, we provide a theoretical analysis on the thermal conductivity of various materials commonly applied to the face using a metallic sphere. Additionally, we observe the impact of environmental conditions on the strength of the polarimetric signature and the ability to recover geometric details. Finally, we show how these materials degrade the performance of traditional face-recognition methods and provide an approach to mitigating this effect using polarimetric-thermal imaging. (C) 2016 Optical Society of America C1 [Short, Nathaniel J.; Yuffa, Alex J.; Videen, Gorden; Hu, Shuowen] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Short, NJ (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM nathaniel.j.short2.ctr@mail.mil RI Yuffa, Alex/B-5498-2014 OI Yuffa, Alex/0000-0002-3600-1131 NR 26 TC 0 Z9 0 U1 2 U2 7 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JUL 1 PY 2016 VL 55 IS 19 BP 5226 EP 5233 DI 10.1364/AO.55.005226 PG 8 WC Optics SC Optics GA DR1TH UT WOS:000379687300037 PM 27409214 ER PT J AU Nesslage, GM Wainger, LA Harms, NE Cofrancesco, AF AF Nesslage, Genevieve M. Wainger, Lisa A. Harms, Nathan E. Cofrancesco, Alfred F. TI Quantifying the population response of invasive water hyacinth, Eichhornia crassipes, to biological control and winter weather in Louisiana, USA SO BIOLOGICAL INVASIONS LA English DT Article DE Biological control; Eichhornia crassipes; Louisiana; Logistic growth; Water hyacinth ID SURPLUS PRODUCTION MODELS; NATURAL MORTALITY; PERFORMANCE; AGE; PARAMETERS; GROWTH AB Water hyacinth, Eichhornia crassipes, is an invasive, tropical, aquatic plant that has caused significant environmental and economic damage since its establishment in Louisiana, USA, in 1884. Both invasion control programs and freezing temperatures are known to negatively affect water hyacinth populations; however, the combined impact of these factors on water hyacinth population dynamics has not yet been quantified, thereby limiting the ability to isolate the effectiveness of biocontrol and other types of control under variable weather conditions. We built a seasonal logistic population model that included time-varying intrinsic growth and overwinter mortality parameters which were estimated by fitting the model to vegetation survey data. We estimated that annual overwinter mortality rates declined from a peak of 71 % in 1977 to the time series low of 11 % in the winter of 1992, followed by an average of 28 % per year from 1993 to 2013. After accounting for the magnitude and trend of overwinter dieback events, our model predicted that the intrinsic growth rate of the Louisiana water hyacinth population declined by 84 % between 1976 and 2013. Despite higher average winter temperatures in recent decades, the population has not rebounded. Our study reveals the dramatic effectiveness of Louisiana's biological control program to successfully suppress water hyacinth invasion. C1 [Nesslage, Genevieve M.; Wainger, Lisa A.] UMCES Chesapeake Biol Lab, 146 Williams St,POB 38, Solomons, MD 20688 USA. [Harms, Nathan E.; Cofrancesco, Alfred F.] US Army, Environm Lab, Engineer Res & Dev Ctr, Waterways Expt Stn, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. RP Nesslage, GM (reprint author), UMCES Chesapeake Biol Lab, 146 Williams St,POB 38, Solomons, MD 20688 USA. EM nesslage@umces.edu RI Nesslage, Genevieve/E-4137-2015; OI Wainger, Lisa/0000-0002-3983-8850 FU US Army Corps of Engineers Aquatic Plant Control Research Program FX We thank Alexander Perret, Michael Harden, and Richard Brassette (ret.) of LDWF for providing vegetation survey data and information about Louisiana's water hyacinth control program. We also thank Anna McMurray for assistance in compiling the data, and Michael Wilberg and Dong Liang for constructive modeling discussions. Funding was provided by the US Army Corps of Engineers Aquatic Plant Control Research Program, under management of Dr. Linda Nelson. This is contribution number 5184 of the University of Maryland Center for Environmental Science. NR 25 TC 0 Z9 0 U1 9 U2 14 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1387-3547 EI 1573-1464 J9 BIOL INVASIONS JI Biol. Invasions PD JUL PY 2016 VL 18 IS 7 BP 2107 EP 2115 DI 10.1007/s10530-016-1155-9 PG 9 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA DP9LA UT WOS:000378816500022 ER PT J AU Pitisuttithum, P Islam, D Chamnanchanunt, S Ruamsap, N Khantapura, P Kaewkungwal, J Kittitrakul, C Luvira, V Dhitavat, J Venkatesan, MM Mason, CJ Bodhidatta, L AF Pitisuttithum, Punnee Islam, Dilara Chamnanchanunt, Supat Ruamsap, Nattaya Khantapura, Patchariya Kaewkungwal, Jaranit Kittitrakul, Chatporn Luvira, Viravarn Dhitavat, Jittima Venkatesan, Malabi M. Mason, Carl J. Bodhidatta, Ladaporn TI Clinical Trial of an Oral Live Shigella sonnei Vaccine Candidate, WRSS1, in Thai Adults SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID FLEXNERI LIPOPOLYSACCHARIDE; ANTIBODY-RESPONSE; ESCHERICHIA-COLI; IMMUNE-RESPONSES; IMMUNOGLOBULIN-A; IMMUNOGENICITY; INFECTIONS; EFFICACY; SURVEILLANCE; MULTICENTER AB Live attenuated Shigella sonnei vaccine candidate WRSS1, previously tested in U.S. and Israeli volunteers, was evaluated in a population of adult Thai volunteers in which the organism is endemic. In a randomized placebo-controlled, double-blind design, inpatient participants received a single oral dose of 1.6 x 10(4) CFU of WRSS1. The vaccine was generally well tolerated, with equal numbers of vaccinees and placebo controls showing mild symptoms. Only 3 of 13 vaccinees (23%) had culture-positive stools, while a total of 9 vaccinees were positive by PCR. Lack of vaccine shedding in volunteers correlated with lack of clinical symptoms and immune responses, just as the duration of fecal shedding correlated directly with stronger immune responses. Two months following immunization, 10 vaccinees and 10 newly recruited naive controls received a challenge dose of 1,670 CFU of virulent S. sonnei strain 53G. This dose had previously demonstrated a 75% attack rate for dysentery in Thai volunteers. However, in this study the attack rate for dysentery in naive controls after challenge was 20%. Based on clinical record summaries, 3 vaccinees and 5 naive controls experienced clinically relevant illness (diarrhea/ dysentery/fever/shigellosis), and a 40% vaccine efficacy was calculated. When these data are compared to those for the performance of this vaccine candidate in more naive populations, it is clear that a single oral dose of WRSS1 at 10(4) CFU failed to achieve its full potential in a population in which the organism is endemic. Higher doses and/or repeated immunizations may contribute to improved vaccine shedding and consequent elevation of protective immune responses in a population in which the organism is endemic. C1 [Pitisuttithum, Punnee; Chamnanchanunt, Supat; Kittitrakul, Chatporn; Luvira, Viravarn; Dhitavat, Jittima] Mahidol Univ, Fac Trop Med, Dept Clin Trop Med, Bangkok, Thailand. [Pitisuttithum, Punnee; Chamnanchanunt, Supat; Kittitrakul, Chatporn; Luvira, Viravarn; Dhitavat, Jittima] Mahidol Univ, Fac Trop Med, Vaccine Trial Ctr, Bangkok, Thailand. [Islam, Dilara; Ruamsap, Nattaya; Khantapura, Patchariya; Mason, Carl J.; Bodhidatta, Ladaporn] Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Kaewkungwal, Jaranit] Mahidol Univ, Fac Trop Med, Bangkok, Thailand. [Venkatesan, Malabi M.] Walter Reed Army Inst Res, Dept Enter Infect, Bacterial Dis Branch, Silver Spring, MD USA. RP Pitisuttithum, P (reprint author), Mahidol Univ, Fac Trop Med, Dept Clin Trop Med, Bangkok, Thailand. EM punnee.pit@mahidol.ac.th OI MASON, CARL/0000-0002-3676-2811 FU HHS \ NIH \ National Institute of Allergy and Infectious Diseases (NIAID) [Y1-AI-4906-03] FX This work, including the efforts of Punnee Pitisuttithum, was funded by HHS vertical bar NIH vertical bar National Institute of Allergy and Infectious Diseases (NIAID) (Y1-AI-4906-03). NR 40 TC 1 Z9 1 U1 4 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 EI 1556-679X J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD JUL PY 2016 VL 23 IS 7 BP 564 EP 575 DI 10.1128/CVI.00665-15 PG 12 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA DQ9GB UT WOS:000379517300006 PM 27146000 ER PT J AU Bauer, PJ Blue, SN Xu, AX Esposito, AG AF Bauer, Patricia J. Blue, Shala N. Xu, Aoxiang Esposito, Alena G. TI Productive Extension of Semantic Memory in School-Aged Children: Relations With Reading Comprehension and Deployment of Cognitive Resources SO DEVELOPMENTAL PSYCHOLOGY LA English DT Article DE knowledge extension; reading comprehension; self-generation; semantic integration; semantic memory ID EYE-MOVEMENTS; INDIVIDUAL-DIFFERENCES; TEXT COMPREHENSION; YOUNG-CHILDREN; GENERATION; KNOWLEDGE; INTEGRATION; INFERENCE; FIXATION; EPISODES AB We investigated 7- to 10-year-old children's productive extension of semantic memory through self-generation of new factual knowledge derived through integration of separate yet related facts learned through instruction or through reading. In Experiment 1, an experimenter read the to-be-integrated facts. Children successfully learned and integrated the information and used it to further extend their semantic knowledge, as evidenced by high levels of correct responses in open-ended and forced-choice testing. In Experiment 2, on half of the trials, the to-be-integrated facts were read by an experimenter (as in Experiment 1) and on half of the trials, children read the facts themselves. Self-generation performance was high in both conditions (experimenter-and self-read); in both conditions, self-generation of new semantic knowledge was related to an independent measure of children's reading comprehension. In Experiment 3, the way children deployed cognitive resources during reading was predictive of their subsequent recall of newly learned information derived through integration. These findings indicate self-generation of new semantic knowledge through integration in school-age children as well as relations between this productive means of extension of semantic memory and cognitive processes engaged during reading. C1 [Bauer, Patricia J.; Blue, Shala N.; Xu, Aoxiang; Esposito, Alena G.] Emory Univ, Dept Psychol, 36 Eagle Row, Atlanta, GA 30322 USA. [Blue, Shala N.] Army Res Inst, Ft Benning, GA USA. RP Bauer, PJ (reprint author), Emory Univ, Dept Psychol, 36 Eagle Row, Atlanta, GA 30322 USA. EM patricia.bauer@emory.edu FU National Institute of Child Health and Human Development [HD067359]; Emory College of Arts and Sciences FX The work was supported by National Institute of Child Health and Human Development Grant HD067359 to Patricia J. Bauer, and by Emory College of Arts and Sciences. We also thank Elizabeth White, Ayla Nolen, Nicole Hattenschwiler, Kristen Tuggle, and Catherine Womick for assistance with participant testing, and other members of the Memory at Emory laboratory group for help at various stages of the research. We also thank the Color Wheel after-school program, Decatur, GA, and the children and parents who took part in the research. NR 42 TC 1 Z9 1 U1 6 U2 7 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0012-1649 EI 1939-0599 J9 DEV PSYCHOL JI Dev. Psychol. PD JUL PY 2016 VL 52 IS 7 BP 1024 EP 1037 DI 10.1037/dev0000130 PG 14 WC Psychology, Developmental SC Psychology GA DQ9AA UT WOS:000379501600002 PM 27253263 ER PT J AU Lotufo, GR Coleman, JG Harmon, AR Chappell, MA Bednar, AJ Russell, AL Smith, JC Brasfield, SM AF Lotufo, Guilherme R. Coleman, Jessica G. Harmon, Ashley R. Chappell, Mark A. Bednar, Anthony J. Russell, Amber L. Smith, Jared C. Brasfield, Sandra M. TI Accumulation of 2,4-dinitroanisole in the earthworm Eisenia fetida from chemically spiked and aged natural soils SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE 2,4-Dinitroanisole; Bioaccumulation; Bioavailability; Earthworm; Aged soil ID INSENSITIVE MUNITIONS COMPOUND; CONVENTIONAL ENERGETICS TNT; RANA-PIPIENS TADPOLES; CONSTITUENTS DNAN; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE; ANDREI; RDX; BIOACCUMULATION; ADSORPTION; TOXICITY AB An initiative within the US military is targeting the replacement of traditional munitions constituents with insensitive munitions to reduce the risk of accidental detonation. The bioavailability and bioaccumulative potential of the insensitive munitions compound 2,4-dinitroanisole (DNAN) to Eisenia fetida was assessed in soils with different geochemical characteristics. Prior to exposure, soils were chemically spiked with DNAN and aged for 1 wk or 29 wk. Transformation products 2- and 4-amino-nitroanisole (2A-4NAN and 4A-2NAN) occurred in aged soils and their porewater but never at concentrations higher than the residual DNAN. The sum of DNAN, 2A-4NAN, and 4A-2NAN (sumDNAN) in soil decreased with aging, likely by irreversible binding. Both clay and organic matter contents of the soil appeared to affect the bioavailability of DNAN. The sumDNAN body residues of earthworms approached apparent steady state after 1 d and remained relatively constant through to day 7. Higher concentrations of 2A-4NAN and 4A-2NAN measured in worm tissues relative to those in soil suggest reductive transformation of DNAN in the tissues. Mean bioaccumulation factors (ratio of tissue to soil concentrations) varied from 1.2 to 4.3, whereas mean bioconcentration factors (ratio of tissue to porewater concentrations) ranged from 1.4 to 3.2. Porewater seems to play a significant role in the accumulation of DNAN in earthworms, consistent with equilibrium partitioning theory. The concentration of DNAN in soil porewater could serve as an indicator of bioavailability as well as a predictor of the concentration of that compound in earthworms. Environ Toxicol Chem 2016;35:1835-1842. Publlished 2015 SETAC. This article is a US Government work, and as such, is in the public domain in the United States of America. C1 [Lotufo, Guilherme R.; Coleman, Jessica G.; Harmon, Ashley R.; Chappell, Mark A.; Bednar, Anthony J.; Russell, Amber L.; Smith, Jared C.; Brasfield, Sandra M.] US Army Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Lotufo, GR (reprint author), US Army Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. EM guilherme.lotufo@usace.army.mil FU US Army's Environmental Quality Technology Basic Research Program FX Permission was granted by the chief of engineers to publish this material. The present work was supported by the US Army's Environmental Quality Technology Basic Research Program (E. Ferguson, technical director). The authors thank G. Sunahara and P. Gong for comments and suggestions that have substantially improved the manuscript and R. Winstead of BAE Systems for help with obtaining insensitive munitions compounds. NR 38 TC 0 Z9 0 U1 6 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD JUL PY 2016 VL 35 IS 7 BP 1835 EP 1842 DI 10.1002/etc.3338 PG 8 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA DQ9RV UT WOS:000379547900027 PM 26666709 ER PT J AU Shanks, GD Burroughs, SA Sohn, JD Waters, NC Smith, VF Waller, M Brundage, JF AF Shanks, G. D. Burroughs, S. A. Sohn, J. D. Waters, N. C. Smith, V. F. Waller, M. Brundage, J. F. TI Enhanced risk of illness during the 1918 influenza pandemic after previous influenza-like illnesses in three military populations SO EPIDEMIOLOGY AND INFECTION LA English DT Article DE influenza; military; mortality; 1918 pandemic ID MORTALITY AB The reasons for the unprecedented mortality during the 1918 influenza pandemic remain poorly understood. We examined morbidity records from three military cohorts from years prior to and during the 1918 pandemic period to assess the effects of previous respiratory illnesses on experiences during the pandemic. Clinical registers and morbidity lists were examined to identify all medical encounters for acute respiratory illnesses in students at two U.S. military officer training academies and Australian soldiers deployed in Europe. Influenza-like illness prior to the major pandemic wave of 1918 predisposed Australian soldiers [relative risk (RR) 1.37, 95% confidence interval (CI) 1.18-1.60, P < 0.0001] and US officer trainees at West Point (RR 3.10, 95% CI 2.13-4.52, P < 0.0001) and Annapolis (RR 2.03, 95% CI 1.65-2.50, P < 0.0001) to increased risks of medically treated illnesses in late 1918. The findings suggest that susceptibility to and/or clinical expressions of the 1918 pandemic influenza virus depended on previous experiences with respiratory infectious agents. The findings are consistent with observations during the 2009 pandemic in Canada and may reflect antibody-dependent enhancement of influenza infection. C1 [Shanks, G. D.] Australian Army Malaria Inst, Enoggera, Australia. [Shanks, G. D.; Waller, M.] Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia. [Burroughs, S. A.; Waters, N. C.] US Mil Acad, Dept Chem, West Point, NY USA. [Sohn, J. D.; Smith, V. F.] US Naval Acad, Dept Chem, Annapolis, MD USA. [Brundage, J. F.] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD USA. RP Shanks, GD (reprint author), Australian Army Malaria Inst, Enoggera, Qld 4051, Australia. EM dennis.shanks@defence.gov.au RI Waller, Michael/R-6231-2016 OI Waller, Michael/0000-0002-1050-4574 FU Global Emerging Infections Surveillance and Response System (GEIS) at the Armed Forces Health Surveillance Center of the U.S. Department of Defense FX The Global Emerging Infections Surveillance and Response System (GEIS) at the Armed Forces Health Surveillance Center of the U.S. Department of Defense provided funding for this project. NR 10 TC 0 Z9 0 U1 3 U2 3 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0950-2688 EI 1469-4409 J9 EPIDEMIOL INFECT JI Epidemiol. Infect. PD JUL PY 2016 VL 144 IS 10 BP 2043 EP 2048 DI 10.1017/S0950268816000479 PG 6 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA DR3EO UT WOS:000379785600003 PM 26957052 ER PT J AU Burk, R Bollinger, L Johnson, JC Wada, J Radoshitzky, SR Palacios, G Bavari, S Jahrling, PB Kuhn, JH AF Burk, Robin Bollinger, Laura Johnson, Joshua C. Wada, Jiro Radoshitzky, Sheli R. Palacios, Gustavo Bavari, Sina Jahrling, Peter B. Kuhn, Jens H. TI Neglected filoviruses SO FEMS MICROBIOLOGY REVIEWS LA English DT Review DE cuevavirus; Ebola; ebolavirus; Filoviridae; filovirus; marburgvirus ID EBOLA-VIRUS-INFECTION; MARBURG HEMORRHAGIC-FEVER; LINKED-IMMUNOSORBENT-ASSAY; ENDOSOMAL CYSTEINE PROTEASES; PROTECTS NONHUMAN-PRIMATES; BATS ROUSETTUS-AEGYPTIACUS; RECEPTOR-DEFICIENT MICE; I INTERFERON RESPONSE; VERVET MONKEY DISEASE; SUBTYPE RESTON VIRUS AB Eight viruses are currently assigned to the family Filoviridae. Marburg virus, Sudan virus and, in particular, Ebola virus have received the most attention both by researchers and the public from 1967 to 2013. During this period, natural human filovirus disease outbreaks occurred sporadically in Equatorial Africa and, despite high case-fatality rates, never included more than several dozen to a few hundred infections per outbreak. Research emphasis shifted almost exclusively to Ebola virus in 2014, when this virus was identified as the cause of an outbreak that has thus far involved more than 28 646 people and caused more than 11 323 deaths in Western Africa. Consequently, major efforts are currently underway to develop licensed medical countermeasures against Ebola virus infection. However, the ecology of and mechanisms behind Ebola virus emergence are as little understood as they are for all other filoviruses. Consequently, the possibility of the future occurrence of a large disease outbreak caused by other less characterized filoviruses (i.e. Bundibugyo virus, Lloviu virus, Ravn virus, Reston virus and Tai Forest virus) is impossible to rule out. Yet, for many of these viruses, not even rudimentary research tools are available, let alone medical countermeasures. This review summarizes the current knowledge on these less well-characterized filoviruses.While Ebola virus dominates the headlines, other filoviruses remain largely uncharacterized but may pose equal risks to humans.While Ebola virus dominates the headlines, other filoviruses remain largely uncharacterized but may pose equal risks to humans. C1 [Burk, Robin; Bollinger, Laura; Johnson, Joshua C.; Wada, Jiro; Jahrling, Peter B.; Kuhn, Jens H.] NIAID, Integrated Res Facil Ft Detrick IRF Frederick, DCR, NIH, B-8200 Res Plaza, Frederick, MD 21702 USA. [Burk, Robin] Heidelberg Univ, Virol, Dept Infect Dis, D-69120 Heidelberg, Baden Wurttembe, Germany. [Radoshitzky, Sheli R.; Palacios, Gustavo; Bavari, Sina] US Army, Med Res Inst Infect Dis USAMRIID, 1425 Porter St, Frederick, MD 21702 USA. RP Kuhn, JH (reprint author), NIAID, Integrated Res Facil Ft Detrick IRF Frederick, DCR, NIH, B-8200 Res Plaza, Frederick, MD 21702 USA. EM kuhnjens@mail.nih.gov RI Palacios, Gustavo/I-7773-2015 OI Palacios, Gustavo/0000-0001-5062-1938 FU Battelle Memorial Institute; US National Institute of Allergy and Infectious Diseases (NIAID) [HHSN272200700016I]; Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology (HBIGS) FX This work was supported in part through Battelle Memorial Institute's prime contract with the US National Institute of Allergy and Infectious Diseases (NIAID) under Contract No. HHSN272200700016I. LB, JCJ and JW performed this work as employees of Battelle Memorial Institute. A subcontractor to Battelle Memorial Institute who performed this work is: JHK, an employee of Tunnell Government Services, Inc. RB is supported by the Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology (HBIGS). The content of this publication does not necessarily reflect the views or policies of the US Department of Health and Human Services, or the institutions and companies affiliated with the authors. NR 219 TC 1 Z9 1 U1 8 U2 15 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0168-6445 EI 1574-6976 J9 FEMS MICROBIOL REV JI Fems Microbiol. Rev. PD JUL PY 2016 VL 40 IS 4 BP 494 EP 519 AR fuw010 DI 10.1093/femsre/fuw010 PG 26 WC Microbiology SC Microbiology GA DR1VY UT WOS:000379694200004 PM 27268907 ER PT J AU Roberts, N Mellott, M Dinger, M Campbell, D AF Roberts, Nicholas Mellott, Mark Dinger, Michael Campbell, Damon TI Electronic medical record system avoidance in a turbulent environment SO INFORMATION & MANAGEMENT LA English DT Article DE Avoidance; IT use behavior; Ambivalence; Health IT; Environmental turbulence; Electronic medical record ID INFORMATION-TECHNOLOGY; HEALTH-CARE; ATTITUDINAL AMBIVALENCE; IMPLEMENTATION; MODEL; RESISTANCE; ORGANIZATIONS; PERSPECTIVE; MANAGEMENT; EMERGENCY AB We attempt to understand why and when physicians avoid electronic medical record (EMR) systems in a turbulent environment. Set in the context of the United States military's combat operations, we develop a research model based on theories of ambivalence in organizations and our particular context. We test our model with 30,677 data points collected from an EMR system. Our results show that avoidance is lower when the potential for information reusability is strong, yet avoidance is higher in urgent care situations. Our study has implications for research, practice, and policy in the area of turbulent healthcare environments. (C) 2016 Elsevier B.V. All rights reserved. C1 [Roberts, Nicholas] Colorado State Univ, Coll Business, Campus Delivery 1277, Ft Collins, CO 80523 USA. [Mellott, Mark] US Army, Washington, DC USA. [Dinger, Michael] Univ South Carolina Upstate, Spartanburg, SC USA. [Campbell, Damon] Millsaps Coll, Jackson, MS USA. RP Roberts, N (reprint author), Colorado State Univ, Coll Business, Campus Delivery 1277, Ft Collins, CO 80523 USA. EM nick.roberts@colostate.edu; mark.d.mellott2.mil@mail.mil; mdinger@uscupstate.edu; damon.campbell@millsaps.edu FU Colorado State University; University of South Carolina Upstate FX We extend our many thanks to Suranjan Chakraborty, Adela Chen, Varun Grover, Matt Jensen, Ulrike Schultze, and Cap Smith for providing feedback on earlier drafts of the manuscript. We are thankful for financial support from Colorado State University and University of South Carolina Upstate. We are also grateful to the associate editor and three anonymous reviewers for encouragement and insight throughout the review process. The views expressed in this manuscript are those of the authors and do not reflect the official policy or position of the Department of the Army, Department of Defense, or the United States Government. NR 74 TC 0 Z9 0 U1 4 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7206 EI 1872-7530 J9 INFORM MANAGE-AMSTER JI Inf. Manage. PD JUL PY 2016 VL 53 IS 5 BP 581 EP 590 DI 10.1016/j.im.2016.01.003 PG 10 WC Computer Science, Information Systems; Information Science & Library Science; Management SC Computer Science; Information Science & Library Science; Business & Economics GA DR0ZS UT WOS:000379636300004 ER PT J AU Gust, KA Collier, ZA Mayo, ML Stanley, JK Gong, P Chappell, MA AF Gust, Kurt A. Collier, Zachary A. Mayo, Michael L. Stanley, Jacob K. Gong, Ping Chappell, Mark A. TI Limitations of toxicity characterization in life cycle assessment: Can adverse outcome pathways provide a new foundation? SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Article DE Life cycle assessment; Quantitative adverse outcome pathway; Toxicity assessment; Characterization factor ID MULTICRITERIA DECISION-ANALYSIS; REPRODUCTIVE ENDOCRINE AXIS; RISK-ASSESSMENT; IMPACT ASSESSMENT; ASSESSMENT METHODOLOGY; PIMEPHALES-PROMELAS; SKIN SENSITIZATION; ADAPTIVE RESPONSES; MULTIMEDIA FATE; IPCS FRAMEWORK AB Life cycle assessment (LCA) has considerable merit for holistic evaluation of product planning, development, production, and disposal, with the inherent benefit of providing a forecast of potential health and environmental impacts. However, a technical review of current life cycle impact assessment (LCIA) methods revealed limitations within the biological effects assessment protocols, including: simplistic assessment approaches and models; an inability to integrate emerging types of toxicity data; a reliance on linear impact assessment models; a lack of methods to mitigate uncertainty; and no explicit consideration of effects in species of concern. The purpose of the current study is to demonstrate that a new concept in toxicological and regulatory assessment, the adverse outcome pathway (AOP), has many useful attributes of potential use to ameliorate many of these problems, to expand data utility and model robustness, and to enable more accurate and defensible biological effects assessments within LCIA. Background, context, and examples have been provided to demonstrate these potential benefits. We additionally propose that these benefits can be most effectively realized through development of quantitative AOPs (qAOPs) crafted to meet the needs of the LCIA framework. As a means to stimulate qAOP research and development in support of LCIA, we propose 3 conceptual classes of qAOP, each with unique inherent attributes for supporting LCIA: 1) mechanistic, including computational toxicology models; 2) probabilistic, including Bayesian networks and supervised machine learning models; and 3) weight of evidence, including models built using decision-analytic methods. Overall, we have highlighted a number of potential applications of qAOPs that can refine and add value to LCIA. As the AOP concept and support framework matures, we see the potential for qAOPs to serve a foundational role for next-generation effects characterization within LCIA. Integr Environ Assess Manag 2016;12:580-590. Published 2015. This article is a US Government work and is in the public domain in the USA. C1 [Gust, Kurt A.; Collier, Zachary A.; Mayo, Michael L.; Stanley, Jacob K.; Gong, Ping; Chappell, Mark A.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Gust, KA (reprint author), US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM Kurt.A.Gust@usace.army.mil FU Military Materials in the Environment (MME) Program for the US Army Engineer Research & Development (ERDC) Laboratory FX Opinions, interpretations, conclusions, and recommendations are those of the author(s) and are not necessarily endorsed by the US Army. We extend kind thanks to the anonymous peer reviewers for their insights and expertise, which helped to substantially refine the content of this paper. This work was funded through the Military Materials in the Environment (MME) Program for the US Army Engineer Research & Development (ERDC) Laboratory. NR 81 TC 0 Z9 0 U1 10 U2 17 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD JUL PY 2016 VL 12 IS 3 BP 580 EP 590 DI 10.1002/ieam.1708 PG 11 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA DQ9SJ UT WOS:000379549300021 PM 26331849 ER PT J AU Mountcastle, C AF Mountcastle, Clay TI The Notorious Isaac Earl and His Scouts: Union Soldiers, Prisoners, Spies. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Mountcastle, Clay] US Army Command, Ft Lee, VA USA. [Mountcastle, Clay] Gen Staff Coll, Ft Lee, VA USA. RP Mountcastle, C (reprint author), US Army Command, Ft Lee, VA USA.; Mountcastle, C (reprint author), Gen Staff Coll, Ft Lee, VA USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2016 VL 80 IS 3 BP 900 EP 901 PG 2 WC History SC History GA DQ5ZK UT WOS:000379283600031 ER PT J AU Solis, G AF Solis, Gary TI American Justice in Taiwan: The 1957 Riots and Cold War Foreign Policy SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Solis, Gary] US Mil Acad, West Point, NY 10996 USA. RP Solis, G (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2016 VL 80 IS 3 BP 950 EP 952 PG 3 WC History SC History GA DQ5ZK UT WOS:000379283600061 ER PT J AU Pugh, C Brown, ES Quinn, XF Korman, L Dyas, BK Ulrich, RG Pittman, PR AF Pugh, Christine Brown, Elizabeth S. Quinn, Xiaofei Korman, Lawrence Dyas, Beverly K. Ulrich, Robert G. Pittman, Phillip R. TI Povidone Iodine Ointment Application to the Vaccination Site Does Not Alter Immunoglobulin G Antibody Response to Smallpox Vaccine SO VIRAL IMMUNOLOGY LA English DT Article ID SURFACE HEPARAN-SULFATE; HUMAN IMMUNE-RESPONSE; CELL-SURFACE; ENVELOPE PROTEIN; PROTECTIVE IMMUNITY; MATURE VIRIONS; A27L PROTEIN; VIRUS; GENE; ACAM2000 AB U.S. military personnel deployed to high-risk areas receive the live vaccinia virus (VACV) smallpox vaccine ACAM2000. VACV shedding from the vaccination site can result in autoinoculation and contact transmission. We previously found that the application of povidone iodine ointment (PIO) to the scarification site reduced viral shedding without altering the antibody response, as measured by plaque reduction neutralization or enzyme-linked immunosorbent assays. In this study, we used protein microarray assays to measure the amount of immunoglobulin G antibody bound to (1) ACAM2000 itself and (2) individual VACV antigens that are present within ACAM2000. We assessed antibody binding in sera from primary smallpox vaccinees who applied PIO to the scarification site beginning on day 7 (PIO group) and from those who did not apply PIO (control group). In both cohorts, the postvaccination antibody response-in terms of antibody binding, both to ACAM2000 and to 11 individual VACV antigens-was significantly greater than the prevaccination response (all p < 0.0001). The postvaccination antibody binding levels of vaccinees in the PIO group did not differ from those of control vaccinees. These findings further support the topical application of PIO, starting on day 7, to reduce the viral shedding associated with smallpox vaccination. C1 [Pugh, Christine; Brown, Elizabeth S.; Quinn, Xiaofei; Korman, Lawrence; Dyas, Beverly K.; Ulrich, Robert G.; Pittman, Phillip R.] US Army, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. RP Pittman, PR (reprint author), US Army, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM phillip.r.pittman.civ@mail.mil FU Military Vaccine Agency, USAMRIID [1491541] FX The research described herein was sponsored by the Military Vaccine Agency, USAMRIID plan number 1491541. This research was supported in part by an appointment of CP to the Postgraduate Research Participation Program at the U.S. Army Medical Research Institute of Infectious Diseases administered by Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USAMRMC. NR 37 TC 0 Z9 0 U1 6 U2 8 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0882-8245 EI 1557-8976 J9 VIRAL IMMUNOL JI Viral Immunol. PD JUL PY 2016 VL 29 IS 6 BP 361 EP 366 DI 10.1089/vim.2016.0025 PG 6 WC Immunology; Virology SC Immunology; Virology GA DQ8GD UT WOS:000379446200006 PM 27214505 ER PT J AU Cheuvront, SN AF Cheuvront, Samuel N. TI Urinalysis for hydration assessment: an age-old problem SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Editorial Material ID OSMOLALITY C1 [Cheuvront, Samuel N.] US Army, Thermal & Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA. RP Cheuvront, SN (reprint author), US Army, Thermal & Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA. EM samuel.n.cheuvront.civ@mail.mil NR 9 TC 1 Z9 1 U1 1 U2 2 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0002-9165 EI 1938-3207 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD JUL PY 2016 VL 104 IS 1 BP 3 EP 4 DI 10.3945/ajcn.116.137703 PG 2 WC Nutrition & Dietetics SC Nutrition & Dietetics GA DQ1RD UT WOS:000378977200002 PM 27305951 ER PT J AU Zylka, JJ Whelan, CJ Molano-Flores, B AF Zylka, Jason J. Whelan, Christopher J. Molano-Flores, Brenda TI Restoration Implications of Land Management Legacy on Aboveground and Seed Bank Composition of North American Grasslands SO AMERICAN MIDLAND NATURALIST LA English DT Article ID TALLGRASS PRAIRIE RESTORATION; VEGETATIVE REPRODUCTION; ANDROPOGON-GERARDII; COMMUNITY STRUCTURE; SPECIES RICHNESS; OLD-FIELD; DYNAMICS; PATTERNS; ILLINOIS; CONSERVATION AB A variety of nonprairie landscapes, including pastures, crop fields, and unmanaged seral ground, are being restored to native prairie on a yearly basis. Seldom is the seed bank associated with these nonprairie lands taken into account in the restoration process. We examine the seed bank potential of nonprairie lands and the relationship between aboveground vegetation and seed bank composition at the largest grassland restoration east of the Mississippi River, the Midewin National Tallgrass Prairie (U.S.A.), by surveying six land management histories: remnant prairie, restored prairie, new pasture, active pasture, old field, and crop field. Both aboveground vegetation and seed bank composition varied with land management history. However, species composition of aboveground vegetation differed significantly from the species composition of the seed bank irrespective of land management history. Aboveground vegetation carried a higher proportion of the seed bank flora than vice versa. In contrast to seed banks of other types of grasslands, the seed bank of historical prairie lands in the U.S. Midwest, irrespective of subsequent land-use history, is not a viable source of species for restoration of tallgrass prairie. A deficiency of many species in the seed bank flora, coupled with an abundance of weedy, often nonnative species, limits the potential contribution of the seed bank to restoration of a prairie vegetation community. Nevertheless, seed bank studies can provide a cost effective method to detect problematic species (i.e., weedy and/or invasive species) and therefore provide a window into the restoration potential of nonprairie lands. C1 [Zylka, Jason J.; Whelan, Christopher J.; Molano-Flores, Brenda] Illinois Nat Hist Survey, 1816 South Oak St, Champaign, IL 61820 USA. [Zylka, Jason J.] Univ Illinois, Dept Nat Resources & Environm Sci, W-503 Turner Hall 1102 South Goodwin Ave, Urbana, IL 61801 USA. [Whelan, Christopher J.] Univ Illinois, Dept Biol Sci, 845 West Taylor St, Chicago, IL 60607 USA. [Zylka, Jason J.] US Army, Corps Engineers, Restorat Ecol, 231 S LaSalle St,Suite 1500, Chicago, IL 60604 USA. RP Molano-Flores, B (reprint author), Illinois Nat Hist Survey, 1816 South Oak St, Champaign, IL 61820 USA. EM jason.zylka@usace.army.mil; molano1@illinois.edu OI Whelan, Christopher/0000-0001-7511-2603 FU Illinois Department of Natural Resources FX We thank the USDA Forest Service for permission to work at Midewin. We are grateful to Jamie Ellis, Paul Marcum, Jean Mengelkoch, Connie Carroll-Cunningham, Loy R. Phillippe, Cindy Jablonski, Rick Larimore, Jim Moody, Jason Willand, Mary Ann Feist, Valerie Sivicek, and Midewin National Tallgrass Prairie staff for fieldwork assistance. Thanks to Jeff Matthews, Janice Coons, and anonymous reviewers for comments. We thank Emily Minor for sharing her expertise on multivariate community analyses and for allowing us to use her lab's computers, and Danielle Ruffatto for help with figures. This study was supported through an Illinois Department of Natural Resources-C2000 Program grant. NR 59 TC 0 Z9 0 U1 24 U2 29 PU AMER MIDLAND NATURALIST PI NOTRE DAME PA UNIV NOTRE DAME, BOX 369, ROOM 295 GLSC, NOTRE DAME, IN 46556 USA SN 0003-0031 EI 1938-4238 J9 AM MIDL NAT JI Am. Midl. Nat. PD JUL PY 2016 VL 176 IS 1 BP 36 EP 59 PG 24 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA DQ5EY UT WOS:000379229000003 ER PT J AU McGann, P Bunin, JL Snesrud, E Singh, S Maybank, R Ong, AC Kwak, YI Seronello, S Clifford, RJ Hinkle, M Yamada, S Barnhill, J Lesho, E AF McGann, Patrick Bunin, Jessica L. Snesrud, Erik Singh, Seema Maybank, Rosslyn Ong, Ana C. Kwak, Yoon I. Seronello, Scott Clifford, Robert J. Hinkle, Mary Yamada, Stephen Barnhill, Jason Lesho, Emil TI Real time application of whole genome sequencing for outbreak investigation - What is an achievable turnaround time? SO DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE LA English DT Article DE Whole genome sequencing; Enterococcus faecium; Turnaround time ID NEXT-GENERATION; ANTIMICROBIAL RESISTANCE; CLINICAL MICROBIOLOGY; ESCHERICHIA-COLI; STAPHYLOCOCCUS-AUREUS; ENTEROCOCCUS-FAECIUM; GLOBAL SPREAD; MRSA; ACINETOBACTER; TRANSMISSION AB Whole genome sequencing (WGS) is increasingly employed in clinical settings, though few assessments of turnaround times (TAT) have been performed in real-time. In this study, WGS was used to investigate an unfolding outbreak of vancomycin resistant Enterococcus faecium (VRE) among 3 patients in the ICU of a tertiary care hospital. Including overnight culturing, a TAT of just 48.5 h for a comprehensive report was achievable using an Illumina Miseq benchtop sequencer. WGS revealed that isolates from patient 2 and 3 differed from that of patient 1 by a single nucleotide polymorphism (SNP), indicating nosocomial transmission. However, the unparalleled resolution provided by WGS suggested that nosocomial transmission involved two separate events from patient 1 to patient 2 and 3, and not a linear transmission suspected by the time line. Rapid TAT's are achievable using WGS in the clinical setting and can provide an unprecedented level of resolution for outbreak investigations. Published by Elsevier Inc. C1 [McGann, Patrick; Snesrud, Erik; Maybank, Rosslyn; Ong, Ana C.; Kwak, Yoon I.; Clifford, Robert J.; Hinkle, Mary; Lesho, Emil] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD USA. [Bunin, Jessica L.] Tripler Army Med Ctr, Dept Crit Care, Honolulu, HI USA. [Singh, Seema; Seronello, Scott; Barnhill, Jason] Tripler Army Med Ctr, Dept Pathol, Honolulu, HI USA. [Yamada, Stephen] Tripler Army Med Ctr, Infect Dis Serv, Honolulu, HI USA. RP McGann, P (reprint author), Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD USA. EM patrick.t.mcgann4.ctr@mail.mil FU U.S. Army Medical Command; Global Emerging Infections Surveillance and Response System; Defence Medical Research and Development Program FX This study was funded by the U.S. Army Medical Command, the Global Emerging Infections Surveillance and Response System, and the Defence Medical Research and Development Program. NR 44 TC 2 Z9 2 U1 2 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0732-8893 EI 1879-0070 J9 DIAGN MICR INFEC DIS JI Diagn. Microbiol. Infect. Dis. PD JUL PY 2016 VL 85 IS 3 BP 277 EP 282 DI 10.1016/j.diagmicrobio.2016.04.020 PG 6 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA DQ1MM UT WOS:000378965100001 PM 27185645 ER PT J AU Deters, D Fowler, SL Orozco, R Smith, PR Spurlock, S Blackmon, D Thomas, S AF Deters, Darlene Fowler, Stephanie L. Orozco, Raymundo Smith, Patrick R. Spurlock, Shelby Blackmon, Darlene Thomas, Samantha TI Myasthenia Gravis Presentation After a Cervical Laminectomy With Fusion SO DIMENSIONS OF CRITICAL CARE NURSING LA English DT Article DE Myasthenia gravis crisis; Neurology; Progressive weakness AB Myasthenia gravis is a chronic neuromuscular disorder that causes skeletal muscle weakness. Typically, myasthenia gravis affects the ocular, bulbar, neck, proximal limbs, and respiratory muscles. Although the presentation is typically observed with complaints of vision and bulbar symptoms such as diplopia, dystonia, and dysphagia, this article presents a case study of an elderly man with a history of increasing upper extremity weakness with complaints of worsening hand dexterity and intermittent episodes of expressive aphasia. After cervical laminectomy with fusion, this gentleman was admitted to the medical intensive care unit, in a complete myasthenic crisis. C1 [Deters, Darlene] San Antonio Mil Med Ctr, Ctr Nursing Sci & Clin Inquiry, Joint Base Ft Sam Houston, Ft Sam Houston, TX USA. [Fowler, Stephanie L.; Orozco, Raymundo; Smith, Patrick R.; Spurlock, Shelby; Blackmon, Darlene; Thomas, Samantha] San Antonio Mil Med Ctr, Crit Care Nursing Serv, Joint Base Ft Sam Houston, Ft Sam Houston, TX USA. [Orozco, Raymundo; Smith, Patrick R.] US Army, Washington, DC USA. [Thomas, Samantha] US Air Force, Washington, DC USA. RP Deters, D (reprint author), 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM darlene.r.deters.civ@mail.mil NR 11 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0730-4625 EI 1538-8646 J9 DIMENS CRIT CARE NUR JI Dimens. Crit. Care Nurs. PD JUL-AUG PY 2016 VL 35 IS 4 BP 190 EP 194 DI 10.1097/DCC.0000000000000189 PG 5 WC Nursing SC Nursing GA DQ3TT UT WOS:000379127000004 PM 27258955 ER PT J AU Xu, XJ Gonzalez, JA Santee, WR Blanchard, LA Hoyt, RW AF Xu, Xiaojiang Gonzalez, Julio A. Santee, William R. Blanchard, Laurie A. Hoyt, Reed W. TI Heat strain imposed by personal protective ensembles: quantitative analysis using a thermoregulation model SO INTERNATIONAL JOURNAL OF BIOMETEOROLOGY LA English DT Article DE Heat stress; Protective clothing; Thermal manikin; Modeling; Metabolic rate; Load carriage ID ENERGY-COST; PHYSIOLOGICAL STRAIN; CLOTHING ENSEMBLES; CORE TEMPERATURE; COLD STRESS; BODY ARMOR; FIREFIGHTERS; PERFORMANCE; ENVIRONMENT; RESISTANCE AB The objective of this paper is to study the effects of personal protective equipment (PPE) and specific PPE layers, defined as thermal/evaporative resistances and the mass, on heat strain during physical activity. A stepwise thermal manikin testing and modeling approach was used to analyze a PPE ensemble with four layers: uniform, ballistic protection, chemical protective clothing, and mask and gloves. The PPE was tested on a thermal manikin, starting with the uniform, then adding an additional layer in each step. Wearing PPE increases the metabolic rates , thus were adjusted according to the mass of each of four configurations. A human thermoregulatory model was used to predict endurance time for each configuration at fixed and at its mass adjusted . Reductions in endurance time due to resistances, and due to mass, were separately determined using predicted results. Fractional contributions of PPE's thermal/evaporative resistances by layer show that the ballistic protection and the chemical protective clothing layers contribute about 20 %, respectively. Wearing the ballistic protection over the uniform reduced endurance time from 146 to 75 min, with 31 min of the decrement due to the additional resistances of the ballistic protection, and 40 min due to increased associated with the additional mass. Effects of mass on heat strain are of a similar magnitude relative to effects of increased resistances. Reducing resistances and mass can both significantly alleviate heat strain. C1 [Xu, Xiaojiang; Gonzalez, Julio A.; Santee, William R.; Blanchard, Laurie A.; Hoyt, Reed W.] US Army, Environm Med Res Inst, Biophys & Biomed Modeling Div, 10 Gen Greene Ave, Natick, MA 01760 USA. RP Xu, XJ (reprint author), US Army, Environm Med Res Inst, Biophys & Biomed Modeling Div, 10 Gen Greene Ave, Natick, MA 01760 USA. EM xiaojiang.xu.civ@mail.mil NR 37 TC 1 Z9 1 U1 7 U2 8 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0020-7128 EI 1432-1254 J9 INT J BIOMETEOROL JI Int. J. Biometeorol. PD JUL PY 2016 VL 60 IS 7 BP 1065 EP 1074 DI 10.1007/s00484-015-1100-0 PG 10 WC Biophysics; Environmental Sciences; Meteorology & Atmospheric Sciences; Physiology SC Biophysics; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences; Physiology GA DQ5RO UT WOS:000379262800012 PM 26638214 ER PT J AU Ursano, RJ Kessler, RC Stein, MB Naifeh, JA Aliaga, PA Fullerton, CS Wynn, GH Vegella, PL Ng, THH Zhang, BG Wryter, CL Sampson, NA Kao, TC Colpe, LJ Schoenbaum, M McCarroll, JE Cox, KL Heeringa, SG AF Ursano, Robert J. Kessler, Ronald C. Stein, Murray B. Naifeh, James A. Aliaga, Pablo A. Fullerton, Carol S. Wynn, Gary H. Vegella, Patti L. Ng, Tsz Hin Hinz Zhang, Bailey G. Wryter, Christina L. Sampson, Nancy A. Kao, Tzu-Cheg Colpe, Lisa J. Schoenbaum, Michael McCarroll, James E. Cox, Kenneth L. Heeringa, Steven G. CA Army STARRS Collaborators TI Risk Factors, Methods, and Timing of Suicide Attempts Among US Army Soldiers SO JAMA PSYCHIATRY LA English DT Article ID MENTAL-HEALTH PROBLEMS; SERVICE MEMBERS; MILITARY; IRAQ; AFGHANISTAN; RESILIENCE; DEPLOYMENT; STARRS; DUTY; POSTDEPLOYMENT AB IMPORTANCE Suicide attempts in the US Army have risen in the past decade. Understanding the association between suicide attempts and deployment, as well as method and timing of suicide attempts, can assist in developing interventions. OBJECTIVE To examine suicide attempt risk factors, methods, and timing among soldiers currently deployed, previously deployed, and never deployed at the time this study was conducted. DESIGN, SETTING, AND PARTICIPANTS This longitudinal, retrospective cohort study of Regular Army-enlisted soldiers on active duty from 2004 through 2009 used individual-level person-month records to examine risk factors (sociodemographic, service related, and mental health), method, and time of suicide attempt by deployment status (never, currently, and previously deployed). Administrative data for the month before each of 9650 incident suicide attempts and an equal-probability sample of 153 528 control person-months for other soldiers were analyzed using a discrete-time survival framework. MAIN OUTCOMES AND MEASURES Suicide attempts and career, mental health, and demographic predictors were obtained from administrative and medical records. RESULTS Of the 9650 enlisted soldiers who attempted suicide, 86.3% were male, 68.4% were younger than 30 years, 59.8% were non-Hispanic white, 76.5% were high school educated, and 54.7% were currently married. The 40.4% of enlisted soldiers who had never been deployed (n = 12 421 294 person-months) accounted for 61.1% of enlisted soldiers who attempted suicide (n = 5894 cases). Risk among those never deployed was highest in the second month of service (103 per 100 000 person-months). Risk among soldiers on their first deployment was highest in the sixth month of deployment (25 per 100 000 person-months). For those previously deployed, risk was highest at 5 months after return (40 per 100 000 person-months). Currently and previously deployed soldiers were more likely to attempt suicide with a firearm than those never deployed (currently deployed: OR, 4.0; 95% CI, 2.9-5.6; previously deployed: OR, 2.7; 95% CI, 1.8-3.9). Across deployment status, suicide attempts were more likely among soldiers who were women (currently deployed: OR, 3.4; 95% CI, 3.0-4.0; previously deployed: OR, 1.5; 95% CI, 1.4-1.7; and never deployed: OR, 2.4; 95% CI, 2.3-2.6), in their first 2 years of service (currently deployed: OR, 1.9; 95% CI, 1.5-2.3; previously deployed: OR, 2.2; 95% CI, 1.9-2.7; and never deployed: OR, 3.1; 95% CI, 2.7-3.6), and had a recently received a mental health diagnosis in the previous month (currently deployed: OR, 29.8; 95% CI, 25.0-35.5; previously deployed: OR, 22.2; 95% CI, 20.1-24.4; and never deployed: OR, 15.0; 95% CI, 14.2-16.0). Among soldiers with 1 previous deployment, odds of a suicide attempt were higher for those who screened positive for depression or posttraumatic stress disorder after return from deployment and particularly at follow-up screening, about 4 to 6 months after deployment (depression: OR, 1.4; 95% CI, 1.1-1.9; posttraumatic stress disorder: OR, 2.4; 95% CI, 2.1-2.8). CONCLUSIONS AND RELEVANCE Identifying the timing and risk factors for suicide attempt in soldiers requires consideration of environmental context, individual characteristics, and mental health. These factors can inform prevention efforts. C1 [Ursano, Robert J.; Naifeh, James A.; Aliaga, Pablo A.; Fullerton, Carol S.; Wynn, Gary H.; Vegella, Patti L.; Ng, Tsz Hin Hinz; Zhang, Bailey G.; Wryter, Christina L.; McCarroll, James E.] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Ctr Study Traumat Stress, Bethesda, MD 20814 USA. [Kessler, Ronald C.; Sampson, Nancy A.] Harvard Med Sch, Dept Hlth Care Policy, Boston, MA USA. [Stein, Murray B.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA. [Stein, Murray B.] Univ Calif San Diego, Dept Family Med & Publ Hlth, La Jolla, CA 92093 USA. [Kao, Tzu-Cheg] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Colpe, Lisa J.; Schoenbaum, Michael] Univ Calif San Diego, La Jolla, CA 92093 USA. [Colpe, Lisa J.; Schoenbaum, Michael] Vet Affairs San Diego Healthcare Syst, La Jolla, CA USA. [Colpe, Lisa J.; Schoenbaum, Michael] NIMH, Bethesda, MD 20892 USA. [Cox, Kenneth L.] US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA. [Heeringa, Steven G.] Univ Michigan, Inst Social Res, Ann Arbor, MI USA. RP Ursano, RJ (reprint author), Uniformed Serv Univ Hlth Sci, Dept Psychiat, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM robert.ursano@usuhs.edu FU Department of the Army [U01MH087981]; US Department of Health and Human Services, National Institutes of Health; National Institute of Mental Health FX Army STARRS was sponsored by the Department of the Army and funded under cooperative agreement U01MH087981 with the US Department of Health and Human Services, National Institutes of Health, and the National Institute of Mental Health. NR 39 TC 2 Z9 2 U1 9 U2 12 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-622X EI 2168-6238 J9 JAMA PSYCHIAT JI JAMA Psychiatry PD JUL PY 2016 VL 73 IS 7 BP 741 EP 749 DI 10.1001/jamapsychiatry.2016.0600 PG 9 WC Psychiatry SC Psychiatry GA DQ2OT UT WOS:000379042700015 PM 27224848 ER PT J AU Hoge, CW Yehuda, R Castro, CA McFarlane, AC Vermetten, E Jetly, R Koenen, KC Greenberg, N Shalev, AY Rauch, SAM Marmar, CR Rothbaum, BO AF Hoge, Charles W. Yehuda, Rachel Castro, Carl A. McFarlane, Alexander C. Vermetten, Eric Jetly, Rakesh Koenen, Karestan C. Greenberg, Neil Shalev, Arieh Y. Rauch, Sheila A. M. Marmar, Charles R. Rothbaum, Barbara O. TI Unintended Consequences of Changing the Definition of Posttraumatic Stress Disorder in DSM-5 Critique and Call for Action SO JAMA PSYCHIATRY LA English DT Article ID IV-TR; PTSD; CRITERIA; PREVALENCE; ICD-11; CHECKLIST; SYMPTOMS; VETERANS; IMPACT; TRIALS C1 [Hoge, Charles W.] US Army Med Res & Mat Command, Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. [Yehuda, Rachel] James J Peters Vet Affairs Med Ctr, Bronx, NY USA. [Yehuda, Rachel] Icahn Sch Med Mt Sinai, New York, NY 10029 USA. [Castro, Carl A.] Univ So Calif, Sch Social Work, Los Angeles, CA 90089 USA. [McFarlane, Alexander C.] Univ Adelaide, Ctr Traumat Stress Studies, Adelaide, SA, Australia. [Vermetten, Eric] Minist Def, Mil Mental Hlth Res Ctr, Utrecht, Netherlands. [Vermetten, Eric] Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands. [Vermetten, Eric] Arq Psychotrauma Expert Grp, Diemen, Netherlands. [Jetly, Rakesh] Directorate Mental Hlth, Canadian Forces Hlth Serv Grp Headquarters, Ottawa, ON, Canada. [Koenen, Karestan C.] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA. [Koenen, Karestan C.] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA. [Greenberg, Neil] Kings Coll London, Kings Ctr Military Hlth Res, London, England. [Shalev, Arieh Y.] NYU Langone Med Ctr, Dept Psychiat, New York, NY USA. [Shalev, Arieh Y.] Hadassah & Hebrew Univ, Sch Med, Jerusalem, Israel. [Rauch, Sheila A. M.; Rothbaum, Barbara O.] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA. [Rauch, Sheila A. M.] Atlanta Vet Affairs Med Ctr, Mental Hlth Serv, Atlanta, GA USA. [Marmar, Charles R.] NYU Langone Med Ctr, Dept Psychiat, Steven & Alexandra Cohen Vet Ctr Posttraumat Stre, New York, NY USA. RP Hoge, CW (reprint author), US Army Med Res & Mat Command, Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM charles.w.hoge.civ@mail.mil OI Shalev, Arieh/0000-0001-9425-050X NR 34 TC 10 Z9 10 U1 11 U2 12 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-622X EI 2168-6238 J9 JAMA PSYCHIAT JI JAMA Psychiatry PD JUL PY 2016 VL 73 IS 7 BP 750 EP 752 DI 10.1001/jamapsychiatry.2016.0647 PG 3 WC Psychiatry SC Psychiatry GA DQ2OT UT WOS:000379042700016 PM 27224895 ER PT J AU Yehuda, R Hoge, CW AF Yehuda, Rachel Hoge, Charles W. TI Treatment Options for Veterans With Posttraumatic Stress Disorder Reply SO JAMA PSYCHIATRY LA English DT Letter ID MENTAL-HEALTH-CARE; PSYCHOTHERAPY; SOLDIERS; DROPOUT; PTSD; IRAQ C1 [Yehuda, Rachel] James J Peters Vet Affairs Med Ctr, Bronx, NY USA. [Yehuda, Rachel] Icahn Sch Med Mt Sinai, 1 Gustave L Levy Pl, New York, NY 10029 USA. [Hoge, Charles W.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Yehuda, R (reprint author), Icahn Sch Med Mt Sinai, 1 Gustave L Levy Pl, New York, NY 10029 USA. EM rachel.yehuda@mssm.edu NR 6 TC 1 Z9 1 U1 1 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-622X EI 2168-6238 J9 JAMA PSYCHIAT JI JAMA Psychiatry PD JUL PY 2016 VL 73 IS 7 BP 758 EP 758 DI 10.1001/jamapsychiatry.2016.0572 PG 1 WC Psychiatry SC Psychiatry GA DQ2OT UT WOS:000379042700021 PM 27191824 ER PT J AU Vo, NQ Sorensen, J Klier, EM Sanaty-Zadeh, A Bayansan, D Seidman, DN Dunand, DC AF Vo, Nhon Q. Sorensen, Jim Klier, Eric M. Sanaty-Zadeh, Amirreza Bayansan, Davaadorj Seidman, David N. Dunand, David C. TI Development of a Precipitation-Strengthened Matrix for Non-quenchable Aluminum Metal Matrix Composites SO JOM LA English DT Article ID MG-SC ALLOY; ELEVATED-TEMPERATURES; TEMPORAL EVOLUTION; AT.PERCENT ALLOYS; AL(SC,ZR) ALLOYS; ZR; SI; AMBIENT; ER; NANOSTRUCTURE AB Recent developments in metal matrix composite-encapsulated ceramic armor show promise in lightweight armor technology. The system contains ceramic tiles, such as alumina, sandwiched between unreinforced aluminum or aluminum metal matrix composite (Al-MMC), which has a better toughness compared to the ceramic tiles. The sandwich structures should not be quenched during the fabrication, as the large mismatch in the coefficients of thermal expansion between the ceramic tiles and the unreinforced aluminum or Al-MMC creates internal stresses high enough to fracture the ceramic tiles. However, slow cooling of most commercial alloys creates large precipitates making solute unavailable for the formation of fine precipitates during aging. Here, we develop a non-quenched, high-strength metal matrix utilizing dilute Al-Sc-Zr alloys. We demonstrate that the dilute Al-0.09 Sc-0.045 Zr at.% alloy and the same alloy containing 0-4 vol.% alumina short fibers do not result in precipitation upon slow cooling from a high temperature, and can thereafter be aged to increase their strength. They exhibit a moderate strength, but improved ductility and toughness as compared to common armor aluminum alloys, such as AA5083-H131, making them attractive as armor materials and hybrid armor systems. C1 [Vo, Nhon Q.; Sanaty-Zadeh, Amirreza; Bayansan, Davaadorj; Seidman, David N.; Dunand, David C.] NanoAl LLC, Skokie, IL 60077 USA. [Sorensen, Jim] CPS Technol, Norton, MA 02766 USA. [Klier, Eric M.] APG, Army Res Lab, Adelphi, MD 21005 USA. [Seidman, David N.; Dunand, David C.] Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA. RP Vo, NQ (reprint author), NanoAl LLC, Skokie, IL 60077 USA. EM nvo@nanoal.com RI Seidman, David/B-6697-2009; Dunand, David/B-7515-2009 FU Army Research Laboratory FX This research was sponsored, in part, by Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-10-2-0098 (V.K. Champagne, monitor). The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, or the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. The authors also gratefully acknowledge CPS Technologies Inc. for fabricating the composite samples. The authors kindly thank M. Burkins (ARL) and B. McWilliams (ARL) for reviewing the manuscript and providing valuable comments. Useful discussions with Prof. D. Luzzi (Northeastern University) are acknowledged. NR 34 TC 0 Z9 0 U1 4 U2 13 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1047-4838 EI 1543-1851 J9 JOM-US JI JOM PD JUL PY 2016 VL 68 IS 7 BP 1915 EP 1924 DI 10.1007/s11837-016-1896-z PG 10 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing SC Materials Science; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing GA DQ2IX UT WOS:000379027100020 ER PT J AU Fouche, P Bruneau, M Chiarito, VP AF Fouche, Pierre Bruneau, Michel Chiarito, Vincent P. TI Modified Steel-Jacketed Columns for Combined Blast and Seismic Retrofit of Existing Bridge Columns SO JOURNAL OF BRIDGE ENGINEERING LA English DT Article DE Jacketed column; Retrofit; Blast testing; Inelastic response; Direct shear; Plastic hinging ID PIERS; TUBE AB Steel jacketing has been used extensively in the United States to retrofit seismically deficient bridge columns. This procedure, which consists of encasing a RC column in a steel jacket, is effective in providing a ductile seismic response but does not enhance the blast resistance of the column. This is because a gap is typically left at the top and bottom of the jacket to prevent increased flexural strength, such as to avoid undesirable overload of the footing or cap beam. Blast tests have demonstrated that direct shear failure can develop at these gap locations. A modification to steel-jacketed columns is proposed here to provide an added blast resistance. It consists of structural steel collars placed around the gaps and tied to the adjacent elements with postinstalled anchors. Blast tests were conducted to investigate the effectiveness of this simple proposed detail. Experimental results indicated that the concept was effective in preventing direct shear failure. Severe blast load demands were applied to investigate the behavior of the retrofitted column under extreme ductility demands. All specimens exhibited satisfactory ductile behavior, except one, which uncharacteristically failed due to fracture of the tube's vertical weld seam. C1 [Fouche, Pierre; Bruneau, Michel] Univ Buffalo, Dept Civil Struct & Environm Engn, Buffalo, NY USA. [Chiarito, Vincent P.] US Army Engineer Res & Dev Ctr, CEERD GSS, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. RP Bruneau, M (reprint author), Univ Buffalo, Dept Civil Struct & Environm Engn, Buffalo, NY USA. EM bruneau@buffalo.edu FU Federal Highway Administration; Infrastructure Protection and Disaster Management Division, Science and Technology Directorate, U.S. Department of Homeland Security; Engineer Research Development Center of the U.S. Army Corps of Engineers [W912HZ-11-2-0001] FX This research was partly supported by the Federal Highway Administration under an award to the Multidisciplinary Center for Earthquake Engineering Research and by the Infrastructure Protection and Disaster Management Division, Science and Technology Directorate, U.S. Department of Homeland Security, under a cooperative agreement with the Engineer Research Development Center of the U.S. Army Corps of Engineers (Contract W912HZ-11-2-0001). Any opinions, findings, conclusions, and recommendations presented in this paper are those of the authors and do not necessarily reflect the views of the sponsors. Permission to publish was granted by the Director, Geotechnical and Structures Laboratory. NR 20 TC 2 Z9 2 U1 8 U2 8 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1084-0702 EI 1943-5592 J9 J BRIDGE ENG JI J. Bridge Eng. PD JUL PY 2016 VL 21 IS 7 AR 04016035 DI 10.1061/(ASCE)BE.1943-5592.0000882 PG 13 WC Engineering, Civil SC Engineering GA DP9XI UT WOS:000378850800005 ER PT J AU Vijay, PV Soti, PR GangaRao, HVS Lampo, RG Clarkson, JD AF Vijay, P. V. Soti, Piyush R. GangaRao, Hota V. S. Lampo, Richard G. Clarkson, John D. TI Repair and Strengthening of Submerged Steel Piles Using GFRP Composites SO JOURNAL OF BRIDGE ENGINEERING LA English DT Article DE Glass-fiber-reinforced polymer (GFRP); Self-consolidated concrete (SCC); FRP rehabilitation; Steel piles; Underwater wrapping; FRP shells; Confinement effect ID FRP COMPOSITES; REINFORCED-CONCRETE; COLUMNS; REHABILITATION; DURABILITY; JACKETS; SIZE AB Steel and concrete bridge structures that serve as the backbone of U.S. transportation and navigational infrastructure systems have been exhibiting moderate to severe deterioration within a few years of service. The focus of this paper is on the rehabilitation of water-submerged bridge steel piles using precured glass-fiber-reinforced polymer (GFRP) shells wrapped with water-curable GFRP prepreg fabrics. The GFRP shells were placed around the corroded steel piles of the East Lynn Lake Campground Bridge in Wayne County, West Virginia, and wrapped with GFRP fabrics. The space between GFRP shells and steel piles was filled with self-consolidating concrete to strengthen and protect the piles from further deterioration. Prior to field implementation, experiments were conducted on concrete cylinders embedded with steel I-sections that were encased by a polymeric shell and FRP wrap system to evaluate the load transfer mechanisms and increase in concrete strength as a result of confinement. To increase the load transfer between embedded steel and concrete, steel rods and angles were welded to the steel I-sections, which resulted in a 92% or higher degree of compositeness. Using the GFRP shell and wrap system, the bridge was restored to its design capacity at approximately 10-15% of its replacement cost. C1 [Vijay, P. V.] West Virginia Univ, Dept Civil & Environm Engn, Constructed Facil Ctr, Morgantown, WV 26506 USA. [Soti, Piyush R.] West Virginia Univ, Dept Civil & Environm Engn, Morgantown, WV 26506 USA. [GangaRao, Hota V. S.] West Virginia Univ, Dept Civil Environm Engn, Constructed Facil Ctr, Morgantown, WV 26506 USA. [Lampo, Richard G.] US Army Corps Engineers, Champaign, IL 61826 USA. [Clarkson, John D.] US Army Corps Engineers, Huntington, WV 25701 USA. RP Vijay, PV (reprint author), West Virginia Univ, Dept Civil & Environm Engn, Constructed Facil Ctr, Morgantown, WV 26506 USA. EM p.vijay@mail.wvu.edu FU USACE; National Science Foundation (NSF) FX The authors gratefully acknowledge the financial support from the USACE, and this work was done through National Science Foundation (NSF) sponsored Industry/University Cooperative Research Center (I/UCRC) entitled Center for Integration of Composites into Infrastructure (CICI) at West Virginia University (WVU). Support from all the engineering and supporting staff of USACE and East Lynn Lake Bridge site is sincerely acknowledged. NR 38 TC 0 Z9 0 U1 8 U2 12 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1084-0702 EI 1943-5592 J9 J BRIDGE ENG JI J. Bridge Eng. PD JUL PY 2016 VL 21 IS 7 AR 04016038 DI 10.1061/(ASCE)BE.1943-5592.0000903 PG 13 WC Engineering, Civil SC Engineering GA DP9XI UT WOS:000378850800013 ER PT J AU Simmons, M Myers, T Guevara, C Jungkind, D Williams, M Houng, HS AF Simmons, Monika Myers, Todd Guevara, Carolina Jungkind, Donald Williams, Maya Houng, Huo-Shu TI Development and Validation of a Quantitative, One-Step, Multiplex, Real-Time Reverse Transcriptase PCR Assay for Detection of Dengue and Chikungunya Viruses SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID POLYMERASE CHAIN-REACTION; RT-PCR; MOLECULAR DIAGNOSIS; HEMORRHAGIC-FEVER; RAPID DETECTION; INFECTION; INDIA; QUANTIFICATION; EPIDEMIC; AMERICA AB Dengue virus (DENV) and chikungunya virus (CHIKV) are important human pathogens with common transmission vectors and similar clinical presentations. Patient care may be impacted by the misdiagnosis of DENV and CHIKV in areas where both viruses cocirculate. In this study, we have developed and validated a one-step multiplex reverse transcriptase PCR (RT-PCR) to simultaneously detect, quantify, and differentiate between four DENV serotypes (pan-DENV) and chikungunya virus. The assay uses TaqMan technology, employing two forward primers, three reverse primers, and four fluorophore-labeled probes in a single- reaction format. Coextracted and coamplified RNA was used as an internal control (IC), and in vitro-transcribed DENV and CHIKV RNAs were used to generate standard curves for absolute quantification. The diagnostic 95% limits of detection (LOD) within the linear range were 50 and 60 RNA copies/ reaction for DENV (serotypes 1 to 4) and CHIKV, respectively. Our assay was able to detect 53 different strains of DENV, representing four serotypes, and six strains of CHIKV. No cross-reactivity was observed with related flaviviruses and alphaviruses, To evaluate diagnostic sensitivity and specificity, 89 clinical samples positive or negative for DENV (serotypes 1 to 4) and CHIKV by the standard virus isolation method were tested in our assay. The multiplex RT-PCR assay showed 95% sensitivity and 100% specificity for DENV and 100% sensitivity and specificity for CHIKV. With an assay turnaround time of less than 2 h, including extraction of RNA, the multiplex quantitative RT-PCR assay provides rapid diagnosis for the differential detection of two clinically indistinguishable diseases, whose geographical occurrence is increasingly overlapping. C1 [Simmons, Monika; Myers, Todd; Williams, Maya] Naval Med Res Ctr, Viral & Rickettsial Dis Dept, Silver Spring, MD USA. [Guevara, Carolina] US Naval Med Res Unit 6, Virol & Emerging Infect Dept, Lima, Peru. [Jungkind, Donald] St Georges Univ, Sch Med, St Georges, Grenada. [Houng, Huo-Shu] Walter Reed Army Inst Res, Div Viral Dis, Silver Spring, MD USA. RP Simmons, M (reprint author), Naval Med Res Ctr, Viral & Rickettsial Dis Dept, Silver Spring, MD USA. EM monika.simmons.civ@mail.mil FU Armed Forces Health Surveillance Branch (AFHSB) Global Emerging Infections Surveillance and Response (GEIS) work unit [P0085-14-NM] FX This work was funded by a grant from the Armed Forces Health Surveillance Branch (AFHSB) Global Emerging Infections Surveillance and Response (GEIS) work unit number P0085-14-NM. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. NR 40 TC 1 Z9 1 U1 2 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JUL PY 2016 VL 54 IS 7 BP 1766 EP 1773 DI 10.1128/JCM.00299-16 PG 8 WC Microbiology SC Microbiology GA DP6WZ UT WOS:000378641600017 PM 27098955 ER PT J AU Frey, DS AF Frey, David Stephen TI A Smashing Success? The Paradox of Hungarian Cultural Imperialism in Nazi New Order Europe, 1939-42 SO JOURNAL OF CONTEMPORARY HISTORY LA English DT Article DE Hungarian Film; imperialism; Jews; Nazi Germany; New Order; Yugoslavia AB This article investigates the flooding of the Yugoslav film market by Hungarian features between 1939 and 1941, the impact of which continued well into 1942. This torrent and the simultaneous expansion of Hungary's domestic market substantially influenced not only the Hungarian film industry, but surprisingly the cultural politics of southeastern Europe during the early imposition of the Nazi New Order. Viewing Hungarian cinematic success through the lens and rhetoric of cultural imperialism, the article examines the centrality of Jewish participation in and expulsion from Hungarian cultural production, Hungary's perception of its role in southeastern Europe, and Nazi Germany's understanding of Hungarian film as an existential threat to its European New Order. By Europeanizing' Hungary's venture in Yugoslavia, the article opens new avenues of thought about the space afforded to small states in Nazi-dominated Europe. It explains how Hungary's achievements in Yugoslavia reinvigorated a faltering industry and allowed Hungary's film establishment the fantasy of perceiving itself, and being perceived by others, as possessing imperial prestige and power. It reveals the malleability of national identities, describing how these identities transformed when crossing borders. Finally, it demonstrates the importance of cultural politics in Nazi thinking, and that force and coercion were central to the New Order at an earlier stage than previously acknowledged. C1 [Frey, David Stephen] US Mil Acad, Hist, West Point, NY 10996 USA. [Frey, David Stephen] US Mil Acad, Ctr Holocaust & Genocide Studies, West Point, NY 10996 USA. RP Frey, DS (reprint author), US Mil Acad, 145 Thayer Hall,Bldg 601, West Point, NY 10996 USA. EM david.frey@usma.edu NR 138 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0022-0094 EI 1461-7250 J9 J CONTEMP HIST JI J. Contemp. Hist. PD JUL PY 2016 VL 51 IS 3 BP 577 EP 605 DI 10.1177/0022009415622804 PG 29 WC History SC History GA DQ4NY UT WOS:000379181800006 ER PT J AU Mendola, JA Johnson, M Goss, D AF Mendola, Jonathan A. Johnson, Michael Goss, Don TI Fibular Fracture in a Female Rugby Player SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Editorial Material C1 [Mendola, Jonathan A.] Quinnipiac Univ, Hamden, CT 06511 USA. [Johnson, Michael; Goss, Don] US Army Baylor Univ Post Profess Sports Med, Phys Therapy Doctoral Residency, West Point, NY USA. [Johnson, Michael; Goss, Don] Keller Army Community Hosp, West Point, NY USA. RP Mendola, JA (reprint author), Quinnipiac Univ, Hamden, CT 06511 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU J O S P T PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 EI 1938-1344 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD JUL PY 2016 VL 46 IS 7 DI 10.2519/jospt.2016.0411 PG 1 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA DQ3UU UT WOS:000379129800013 PM 27363575 ER PT J AU Atesok, K Doral, MN Karlsson, J Egol, KA Jazrawi, LM Coelho, PG Martinez, A Matsumoto, T Owens, BD Ochi, M Hurwitz, SR Atala, A Fu, FH Lu, HH Rodeo, SA AF Atesok, Kivanc Doral, M. Nedim Karlsson, Jon Egol, Kenneth A. Jazrawi, Laith M. Coelho, Paulo G. Martinez, Amaury Matsumoto, Tomoyuki Owens, Brett D. Ochi, Mitsuo Hurwitz, Shepard R. Atala, Anthony Fu, Freddie H. Lu, Helen H. Rodeo, Scott A. TI Multilayer scaffolds in orthopaedic tissue engineering SO KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY LA English DT Article DE Orthopaedic tissue engineering; Interface tissue regeneration; Multilayer scaffolds; Multi-lineage cell differentiation ID OSTEOCHONDRAL REGENERATION; BIPHASIC SCAFFOLD; BONE-CEMENT; SHEEP MODEL; INTERFACE; TENDON; BIOMATERIAL; REPAIR AB The purpose of this study was to summarize the recent developments in the field of tissue engineering as they relate to multilayer scaffold designs in musculoskeletal regeneration. Clinical and basic research studies that highlight the current knowledge and potential future applications of the multilayer scaffolds in orthopaedic tissue engineering were evaluated and the best evidence collected. Studies were divided into three main categories based on tissue types and interfaces for which multilayer scaffolds were used to regenerate: bone, osteochondral junction and tendon-to-bone interfaces. In vitro and in vivo studies indicate that the use of stratified scaffolds composed of multiple layers with distinct compositions for regeneration of distinct tissue types within the same scaffold and anatomic location is feasible. This emerging tissue engineering approach has potential applications in regeneration of bone defects, osteochondral lesions and tendon-to-bone interfaces with successful basic research findings that encourage clinical applications. Present data supporting the advantages of the use of multilayer scaffolds as an emerging strategy in musculoskeletal tissue engineering are promising, however, still limited. Positive impacts of the use of next generation scaffolds in orthopaedic tissue engineering can be expected in terms of decreasing the invasiveness of current grafting techniques used for reconstruction of bone and osteochondral defects, and tendon-to-bone interfaces in near future. C1 [Atesok, Kivanc; Rodeo, Scott A.] Hosp Special Surg, Sports Med & Shoulder Serv, 525 East 71st St, New York, NY 10021 USA. [Doral, M. Nedim] Hacettepe Univ, Dept Orthopaed & Traumatol, Sch Med, TR-06100 Ankara, Turkey. [Karlsson, Jon] Gothenburg Univ, Sahlgrenska Univ Hosp, Sahlgrenska Acad, Dept Orthopaed, S-43180 Molndal, Sweden. [Egol, Kenneth A.] NYU, Dept Orthopaed Surg, Hosp Joint Dis, 303 2nd Ave, New York, NY 10003 USA. [Jazrawi, Laith M.; Martinez, Amaury] NYU, Ctr Musculoskeletal Care, Hosp Joint Dis, 333 East 38th St, New York, NY 10016 USA. [Coelho, Paulo G.] NYU, Dept Periodontol & Implant Dent, Coll Dent, 345 East 24th St,Room 804s, New York, NY 10010 USA. [Matsumoto, Tomoyuki] Kobe Univ, Dept Orthopaed Surg, Grad Sch Med, Chuo Ku, Kobe, Hyogo 6500017, Japan. [Owens, Brett D.] Keller Army Hosp, Orthopaed Surg Serv, 900 Washington Rd, New York, NY 10996 USA. [Ochi, Mitsuo] Hiroshima Univ, Dept Orthopaed Surg, Sch Biomed Sci, Minamimi Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan. [Hurwitz, Shepard R.] Univ N Carolina, Dept Orthopaed Surg, Chapel Hill, NC USA. [Hurwitz, Shepard R.] Amer Board Orthopaed Surg, 400 Silver Cedar Court, Chapel Hill, NC 27514 USA. [Atala, Anthony] Wake Forest Univ, Sch Med, Wake Forest Inst Regenerat Med, Winston Salem, NC 27157 USA. [Fu, Freddie H.] Univ Pittsburgh, Sch Med, Dept Orthopaed Surg, 3471 Fifth Ave,Suite 1011, Pittsburgh, PA 15213 USA. [Lu, Helen H.] Columbia Univ, Dept Biomed Engn, New York, NY 10016 USA. RP Rodeo, SA (reprint author), Hosp Special Surg, Sports Med & Shoulder Serv, 525 East 71st St, New York, NY 10021 USA. EM kivanc.atesok@utoronto.ca; RodeoS@HSS.edu RI Bayram, Cem/D-7403-2013 OI Bayram, Cem/0000-0001-8717-4668 NR 36 TC 0 Z9 0 U1 10 U2 12 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0942-2056 EI 1433-7347 J9 KNEE SURG SPORT TR A JI Knee Surg. Sports Traumatol. Arthrosc. PD JUL PY 2016 VL 24 IS 7 BP 2365 EP 2373 DI 10.1007/s00167-014-3453-z PG 9 WC Orthopedics; Sport Sciences; Surgery SC Orthopedics; Sport Sciences; Surgery GA DQ4HO UT WOS:000379165000043 PM 25466277 ER PT J AU Modjarrad, K Moorthy, VS Ben Embarek, P Van Kerkhove, M Kim, J Kieny, MP AF Modjarrad, Kayvon Moorthy, Vasee S. Ben Embarek, Peter Van Kerkhove, Maria Kim, Jerome Kieny, Marie-Paule TI A roadmap for MERS-CoV research and product development: report from a World Health Organization consultation SO NATURE MEDICINE LA English DT Article ID EAST RESPIRATORY SYNDROME; SYNDROME CORONAVIRUS INFECTION; MOUSE MODEL; GENERATION AB As part of the World Health Organization (WHO) R&D Blueprint initiative, leading stakeholders on Middle East respiratory syndrome coronavirus (MERS-CoV) convened to agree on strategic public-health goals and global priority research activities that are needed to combat MERS-CoV. C1 [Modjarrad, Kayvon] US Mil HIV Res Program, Walter Reed Army Inst Res, Silver Spring, MD USA. [Moorthy, Vasee S.; Ben Embarek, Peter; Kieny, Marie-Paule] WHO, Geneva, Switzerland. [Van Kerkhove, Maria] Inst Pasteur, Ctr Global Hlth, Paris, France. [Kim, Jerome] Int Vaccine Inst, Seoul, South Korea. RP Moorthy, VS (reprint author), WHO, Geneva, Switzerland. EM moorthyv@who.int FU World Health Organization [001] NR 21 TC 0 Z9 0 U1 2 U2 8 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1078-8956 EI 1546-170X J9 NAT MED JI Nat. Med. PD JUL PY 2016 VL 22 IS 7 BP 701 EP 705 PG 5 WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental Medicine GA DQ7DK UT WOS:000379366900004 PM 27387881 ER PT J AU Friedl, KE Hubbard, VS AF Friedl, Karl E. Hubbard, Van S. TI What Can We Learn from Critical Periods of Weight Gain in Military Personnel? SO OBESITY LA English DT Editorial Material ID OBESITY; OVERWEIGHT; SERVICE C1 [Friedl, Karl E.] US Army, Frederick, MD USA. [Hubbard, Van S.] US PHS, Bethesda, MD 20814 USA. [Hubbard, Van S.] NIH, Bldg 10, Bethesda, MD 20892 USA. RP Hubbard, VS (reprint author), US PHS, Bethesda, MD 20814 USA.; Hubbard, VS (reprint author), NIH, Bldg 10, Bethesda, MD 20892 USA. EM vshubbard@alumni.union.edu NR 7 TC 1 Z9 1 U1 1 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1930-7381 EI 1930-739X J9 OBESITY JI Obesity PD JUL PY 2016 VL 24 IS 7 BP 1408 EP 1409 DI 10.1002/oby.21546 PG 2 WC Endocrinology & Metabolism; Nutrition & Dietetics SC Endocrinology & Metabolism; Nutrition & Dietetics GA DQ6GT UT WOS:000379303200002 PM 27345960 ER PT J AU Austin, KG Price, LL McGraw, SM Leahy, G Lieberman, HR AF Austin, Krista G. Price, Lori Lyn McGraw, Susan M. Leahy, Guy Lieberman, Harris R. TI Demographic, Lifestyle Factors, and Reasons for Use of Dietary Supplements by Air Force Personnel SO AEROSPACE MEDICINE AND HUMAN PERFORMANCE LA English DT Article DE multivitamin; protein supplements; deployment history; military operations; Armed Forces; occupational health ID PREVALENT; ADULTS AB BACKGROUND: Dietary supplement (DS) use is common among U.S. Army personnel to purportedly improve health, provide energy, and increase strength. However, a comprehensive analysis of DS use among U.S. Air Force (USAF) personnel has not been conducted using the same survey instrument, which would permit direct comparisons to DS use by Army personnel. METHODS: A standardized questionnaire was used to assess DS use, demographic factors, and reasons for use of DS by USAF personnel (N = 1750). Logistic regression models adjusted for age, sex, and rank were used to determine relationships among categories of DS (multivitamin and multimineral, individual vitamins and minerals, protein/amino acid supplements, combination products, herbal supplements, purported steroid analogs, and other) and demographic factors. Findings were compared to reports from other military services and civilian populations. RESULTS: DS were used by 68% of USAF personnel: 35% used 1-2 DS >= 1 time/wk, 13% 3-4 DS >= 1 time/wk, and 20% >= 5 DS >= 1 time/wk. There were 45% of personnel who used a multivitamin and mineral, 33% protein supplements, 22% individual vitamins/minerals, 22% combination products, and 7% herbals. Logistic regression demonstrated aerobic exercise duration and strength training were associated with increased DS use. Individuals who previously deployed were more likely to use DS. CONCLUSIONS: Like Army personnel, college students and athletes, USAF personnel use more DS than the general population and are more likely to use purported performance enhancing DS, such as protein supplements, and concurrently consume multiple DS. C1 [Austin, Krista G.; McGraw, Susan M.; Lieberman, Harris R.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. [Austin, Krista G.] Oak Ridge Inst Sci & Educ, Belcamp, MD USA. [Price, Lori Lyn] Tufts Med Ctr, Inst Clin Res & Hlth Policy Studies, Boston, MA USA. [Price, Lori Lyn] Tufts Univ, Tufts Clin & Translat Sci Inst, Boston, MA 02111 USA. [Leahy, Guy] Vet Adm Med Ctr, Durham, NC USA. RP Lieberman, HR (reprint author), US Army, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. EM harris.r.lieberman.civ@mail.mil FU U.S. Army Medical Research and Materiel Command (USAMRMC); Department of Defence Center Alliance for Nutrition and Dietary Supplements Research FX This work was supported by the U.S. Army Medical Research and Materiel Command (USAMRMC) and the Department of Defence Center Alliance for Nutrition and Dietary Supplements Research. The opinions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Army or the Department of Defense. Citations of commercial organizations and trade names in this report do not constitute an official Department of the Army endorsement or approval of the products or services of these organizations. NR 26 TC 2 Z9 2 U1 3 U2 4 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 2375-6314 EI 2375-6322 J9 AEROSP MED HUM PERF JI Aerosp. Med.Hum. Perform. PD JUL PY 2016 VL 87 IS 7 BP 628 EP 637 DI 10.3357/AMHP.4513.2016 PG 10 WC Biophysics; Public, Environmental & Occupational Health; Medicine, Research & Experimental SC Biophysics; Public, Environmental & Occupational Health; Research & Experimental Medicine GA DP4LB UT WOS:000378466300007 PM 27503043 ER PT J AU Autor, DH Duggan, M Greenberg, K Lyle, DS AF Autor, David H. Duggan, Mark Greenberg, Kyle Lyle, David S. TI The Impact of Disability Benefits on Labor Supply: Evidence from the VA's Disability Compensation Program SO AMERICAN ECONOMIC JOURNAL-APPLIED ECONOMICS LA English DT Article ID INSURANCE RECEIPT; VETERANS; RISE; SUBSTITUTION; EARNINGS; HEALTH; INCOME AB Combining administrative data from the US Army, Department of Veterans Affairs, and Social Security Administration, we analyze the effect of the VA's Disability Compensation (DC) program on veterans' labor force participation and earnings. We study the 2001 Agent Orange decision, a unique policy change that expanded DC eligibility for Vietnam veterans who served in theater but did not expand eligibility to other veterans of this era, to assess the causal effects of DC enrollment. We estimate that benefits receipt reduced veterans' labor force participation by 18 percentage points, though measured income net of transfer income rose on average. C1 [Autor, David H.] MIT, Dept Econ, 50 Mem Dr,E52-371, Cambridge, MA 02142 USA. [Autor, David H.; Duggan, Mark] Natl Bur Econ Res, Cambridge, MA 02138 USA. [Duggan, Mark] Stanford Univ, Dept Econ, 579 Serra Mall, Stanford, CA 94305 USA. [Greenberg, Kyle; Lyle, David S.] US Mil Acad, Dept Social Sci, 607 Cullum Rd, West Point, NY 10996 USA. RP Autor, DH (reprint author), MIT, Dept Econ, 50 Mem Dr,E52-371, Cambridge, MA 02142 USA.; Autor, DH (reprint author), Natl Bur Econ Res, Cambridge, MA 02138 USA. EM dautor@mit.edu; mgdug-gan@stanford.edu; kyle.greenberg@usma.edu; david.lyle@usma.edu FU US Social Security Administration [10-P-98363-1-05] FX This research was supported by the US Social Security Administration through grant #10-P-98363-1-05 to the National Bureau of Economic Research as part of the SSA Retirement Research Consortium. The views and findings expressed herein are those of the authors and do not purport to reflect the position of the US Military Academy, the Department of the Army, the Department of Defense, the SSA, or the NBER. We are grateful to Josh Angrist, Orley Ashenfelter, Mary Daly, two anonymous referees, and seminar participants at Arizona State University, Brown University, the Federal Reserve Board, Princeton University, RAND, Stanford University, and the University of California at Berkeley for helpful comments. We are indebted to Luke Gallagher of the Army Office of Economic Manpower Analysis for outstanding research assistance and to Mike Risha of the Social Security Administration for assistance with all aspects of data development and interpretation. NR 30 TC 0 Z9 0 U1 3 U2 4 PU AMER ECONOMIC ASSOC PI NASHVILLE PA 2014 BROADWAY, STE 305, NASHVILLE, TN 37203 USA SN 1945-7782 EI 1945-7790 J9 AM ECON J-APPL ECON JI Am. Econ. J.-Appl. Econ. PD JUL PY 2016 VL 8 IS 3 BP 31 EP 68 DI 10.1257/app.20150158 PG 38 WC Economics SC Business & Economics GA DP9MB UT WOS:000378819200002 ER PT J AU Hauser, WL AF Hauser, William L. TI Lady Leathernecks: The Enigma of Women in the United States Marine Corps SO ARMED FORCES & SOCIETY LA English DT Book Review C1 [Hauser, William L.] US Army, Reston, VA 22096 USA. RP Hauser, WL (reprint author), US Army, Reston, VA 22096 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0095-327X EI 1556-0848 J9 ARMED FORCES SOC JI Armed Forces Soc. PD JUL PY 2016 VL 42 IS 3 BP 626 EP 629 DI 10.1177/0095327X15622282 PG 4 WC Political Science; Sociology SC Government & Law; Sociology GA DP3VZ UT WOS:000378425300008 ER PT J AU de Bejar, LA Danielson, KT AF de Bejar, Luis A. Danielson, Kent T. TI Critical Time-Step Estimation for Explicit Integration of Dynamic Higher-Order Finite-Element Formulations SO JOURNAL OF ENGINEERING MECHANICS LA English DT Article DE Central-difference scheme; Critical time step; Explicit integration; Higher-order finite elements; Largest eigenvalue ID TETRAHEDRAL ELEMENTS AB Higher-order elements frequently render accurate results and allow the reduction of the total number of elements required to represent a given structure. However, element order also affects the efficient time-history integration of the associated equations of motion in Lagrangian dynamics by an explicit method, which is only conditionally stable. The integration time step is affected by element type and must be sufficiently small to avoid instability of the computed solution and, simultaneously, should be sufficiently large for an economic analysis. The upper bound to the size of this step in an analysis is rigorously obtained from the solution of the eigenvalue problem to the global system of equations of the entire finite-element model. Common alternatives to this computation are to approximate the time step by much simpler one-dimensional node-to-node or individual elemental eigenvalue approaches. Robust higher-order finite-element formulations have recently been developed for explicit integration, but time-step determinations have been primarily limited to the one-dimensional approach. In this paper, the individual elemental eigenvalue approach is further used to study the critical time step for several practical higher-order element types (27-node bricks, 16-node thin plates, 15-node tetrahedra, and 21-node wedges). Parametric studies on the variables controlling their critical time steps are discussed. C1 [de Bejar, Luis A.; Danielson, Kent T.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP de Bejar, LA (reprint author), US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM Luis.A.DeBejar@erdc.usace.army.mil FU DOD High Performance Computing Modernization Program at the ERDC DOD Supercomputing Resource Center (DSRC) FX Permission to publish was granted by the Director, Geotechnical and Structures Laboratory. This investigation was partially supported by grants from the DOD High Performance Computing Modernization Program at the ERDC DOD Supercomputing Resource Center (DSRC). NR 19 TC 0 Z9 0 U1 4 U2 4 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9399 EI 1943-7889 J9 J ENG MECH JI J. Eng. Mech. PD JUL PY 2016 VL 142 IS 7 AR 04016043 DI 10.1061/(ASCE)EM.1943-7889.0001082 PG 12 WC Engineering, Mechanical SC Engineering GA DP9YR UT WOS:000378854500003 ER PT J AU Grujicic, M Snipes, JS Ramaswami, S Yen, CF AF Grujicic, M. Snipes, J. S. Ramaswami, S. Yen, C-F TI A Combined Experimental/Computational Analysis of the Butt-Friction-Stir-Welded AA2139-T8 Joints SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE LA English DT Article DE friction stir welding; weld-material-property characterization; weld zones ID CU-MG-AG; MICROSTRUCTURE EVOLUTION; 6061-T6 ALUMINUM; CRACK-GROWTH; ALLOYS; PRECIPITATION; SIMULATION; PARAMETERS; AA5083; ARMOR AB Combined experimental and computational investigations are carried out of the mechanical properties of materials residing in different weld zones of friction stir-welded (FSW) joints of thick plates of AA2139-T8. The experimental portion of the work comprised (a) identification of the weld zones within the FSW joints, through the use of optical-microscopy characterization of a transverse section; (b) validation of the weld zones identified in (a) via the generation of a micro-hardness field over the same transverse section; (c) extracting and subsequently testing miniature tensile specimens from different weld zones; and (d) extracting and testing a larger-size tensile specimen spanning transversely the FSW weld. The computational portion of the work comprised (i) validation of the mechanical properties, as determined experimentally using the miniature tensile specimens, of the material residing within different zones of the FSW joint; and (ii) clarification of the benefits yielded by the knowledge of the local material properties within the FSW joint. These benefits arise from the fact that (a) joint mechanical properties are generally inferior to those of the base metal; (b) the width of the weld in thick metallic-armor is often comparable to the armor thickness, and therefore may represent a significant portion of the armor exposed-surface area; and (c) modeling of the weld-material structural response under loading requires the availability of high-fidelity/validated material constitutive models, and the development of such models requires knowledge of the local weld-material mechanical properties. C1 [Grujicic, M.; Snipes, J. S.; Ramaswami, S.] Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. [Yen, C-F] US Army, Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM gmica@clemson.edu FU Army Research Office (ARO) [W911NF-11-1-0207] FX The material presented in this paper is based on work supported by an Army Research Office (ARO) sponsored grant entitled "Friction Stir Welding Behavior of Selected 2000-series and 5000-series Aluminum Alloys" (Contract Number W911NF-11-1-0207). The authors are indebted to Dr. Asher Rubinstein of ARO for his continuing support and interest in the present work. NR 42 TC 0 Z9 0 U1 7 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9495 EI 1544-1024 J9 J MATER ENG PERFORM JI J. Mater. Eng. Perform. PD JUL PY 2016 VL 25 IS 7 BP 2690 EP 2701 DI 10.1007/s11665-016-2133-1 PG 12 WC Materials Science, Multidisciplinary SC Materials Science GA DQ0DU UT WOS:000378869400015 ER PT J AU Jones, K Choi, JH Sponsel, WE Gray, W Groth, SL Glickman, RD Lund, BJ Reilly, MA AF Jones, Kirstin Choi, Jae-Hyek Sponsel, William E. Gray, Walt Groth, Sylvia L. Glickman, Randolph D. Lund, Brian J. Reilly, Matthew A. TI Low-Level Primary Blast Causes Acute Ocular Trauma in Rabbits SO JOURNAL OF NEUROTRAUMA LA English DT Article DE animal model; head trauma; models of injury; ocular blast trauma; primary blast trauma ID MOUSE MODEL; INJURY; MIGRATION; VISION; CORNEA; DAMAGE; EDEMA AB The objective of this study was to determine whether clinically significant ocular trauma can be induced by a survivable isolated primary blast using a live animal model. Both eyes of 18 Dutch Belted rabbits were exposed to various survivable low-level blast overpressures in a large-scale shock tube simulating a primary blast similar to an improvised explosive device. Eyes of the blast-exposed rabbits (as well as five control rabbits) were thoroughly examined before and after blast to detect changes. Clinically significant changes in corneal thickness arose immediately after blast and were sustained through 48 h, suggesting possible disruption of endothelial function. Retinal thickness (RT) increased with increasing specific impulse immediately after exposure. Intraocular pressure (TOP) was inversely correlated with the specific impulse of the blast wave. These findings clearly indicate that survivable primary blast causes ocular injuries with likely visual functional sequelae of clinical and military relevance. C1 [Jones, Kirstin; Sponsel, William E.; Reilly, Matthew A.] Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX 78249 USA. [Gray, Walt] Univ Texas San Antonio, Dept Geol Sci, San Antonio, TX 78249 USA. [Choi, Jae-Hyek; Lund, Brian J.] US Army Inst Surg Res, San Antonio, TX USA. [Sponsel, William E.] WESMD Profess Associates, San Antonio, TX USA. [Sponsel, William E.] Univ Incarnate Word, Rosenberg Sch Optometry, San Antonio, TX USA. [Groth, Sylvia L.] Univ N Carolina, Dept Ophthalmol, Chapel Hill, NC USA. [Glickman, Randolph D.] Univ Texas Hlth Sci Ctr San Antonio, Dept Ophthalmol, San Antonio, TX 78229 USA. RP Reilly, MA (reprint author), Univ Texas San Antonio, Biomed Engn, San Antonio, TX 78249 USA. EM matthew.reilly@utsa.edu OI Reilly, Matthew/0000-0001-8029-0084 NR 34 TC 0 Z9 0 U1 2 U2 2 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL 1 PY 2016 VL 33 IS 13 BP 1194 EP 1201 DI 10.1089/neu.2015.4022 PG 8 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DP2QY UT WOS:000378336200385 PM 26393900 ER PT J AU Arun, P Rittase, W Wilder, D Wang, Y Gist, I Long, J AF Arun, Peethambaran Rittase, William Wilder, Donna Wang, Ying Gist, Irene Long, Joseph TI ALTERED METHIONINE METABOLISM IN THE BRAIN AFTER REPEATED BLAST EXPOSURES MIGHT CONTRIBUTE TO INCREASED OXIDATIVE STRESS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 34th Annual National Neurotrauma Symposium CY JUN 26-29, 2016 CL Lexington, KY DE metabolites; amino acids; antioxidants; oxidative stress C1 [Arun, Peethambaran; Rittase, William; Wilder, Donna; Wang, Ying; Gist, Irene; Long, Joseph] Walter Reed Army Inst Res, Blast Induced Neurotrauma, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL 1 PY 2016 VL 33 IS 13 MA PSB-212 BP A88 EP A89 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DP2QY UT WOS:000378336200241 ER PT J AU Boutte, A Abbatiello, B Grant, S Cartagena, C Johnson, D Shear, D AF Boutte, Angela Abbatiello, Brittany Grant, Shonnette Cartagena, Casandra Johnson, David Shear, Deborah TI DIFFERENTIAL ABUNDANCE OF TOTAL AND PHOSPHORYLATED TAU IN BRAIN TISSUE AND BIOFLUIDS DURING SUBACUTE PENETRATING BRAIN INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 34th Annual National Neurotrauma Symposium CY JUN 26-29, 2016 CL Lexington, KY DE Severe TBI; tau; phosphorylated tau; serum C1 [Boutte, Angela; Abbatiello, Brittany; Grant, Shonnette; Cartagena, Casandra; Johnson, David; Shear, Deborah] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL 1 PY 2016 VL 33 IS 13 MA PSB-198 BP A83 EP A84 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DP2QY UT WOS:000378336200227 ER PT J AU Boutte, A Abbatiello, B Grant, S Hook, G Hook, V Shear, D AF Boutte, Angela Abbatiello, Brittany Grant, Shonnette Hook, Gregory Hook, Vivian Shear, Deborah TI BRAIN CATHEPSIN B PROTEIN LEVELS AND CYSTEINE PROTEASE ACTIVITY ARE AFFECTED BY SUBACUTE CRANIOTOMY AND PENETRATING BRAIN TRAUMA SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 34th Annual National Neurotrauma Symposium CY JUN 26-29, 2016 CL Lexington, KY DE cathepsin B; cysteine protease activity; craniotomy C1 [Boutte, Angela; Abbatiello, Brittany; Grant, Shonnette; Shear, Deborah] Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat Branch, Silver Spring, MD USA. [Hook, Gregory] Amer Life Sci Pharmaceut Inc, La Jolla, CA USA. [Hook, Vivian] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, Dept Neurosci, La Jolla, CA 92093 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL 1 PY 2016 VL 33 IS 13 MA PSB-185 BP A79 EP A79 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DP2QY UT WOS:000378336200214 ER PT J AU Browning, J Deng-Bryant, Y Madathil, S Pedersen, R Sun, J Hahn, J Gilsdorf, J Tortella, F Mondello, S Shear, D AF Browning, Jenny Deng-Bryant, Ying Madathil, Sindhu Pedersen, Rebecca Sun, Justin Hahn, Justin Gilsdorf, Janice Tortella, Frank Mondello, Stefania Shear, Deborah TI EVALUATION OF AER-271 IN THE WRAIR PBBI MODEL: STUDIES FROM THE OPERATION BRAIN TRAUMA THERAPY CONSORTIUM SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 34th Annual National Neurotrauma Symposium CY JUN 26-29, 2016 CL Lexington, KY DE Neuroprotection; Aquaporin 4; Therapeutics; Operation Brain Trauma Therapy Consortium C1 [Browning, Jenny; Deng-Bryant, Ying; Madathil, Sindhu; Pedersen, Rebecca; Sun, Justin; Hahn, Justin; Gilsdorf, Janice; Tortella, Frank; Mondello, Stefania; Shear, Deborah] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL 1 PY 2016 VL 33 IS 13 MA PSA-145 BP A64 EP A64 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DP2QY UT WOS:000378336200173 ER PT J AU Caudle, K Sun, J Pedersen, R Hahn, J Okada-Rising, S Pandya, J Shear, D AF Caudle, Krista Sun, Justin Pedersen, Rebecca Hahn, Justin Okada-Rising, Starlyn Pandya, Jignesh Shear, Deborah TI DOSE-RESPONSE EVALUATION OF LEVETIRACETAM IN A RAT MODEL OF PENETRATING BALLISTIC-LIKE BRAIN INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 34th Annual National Neurotrauma Symposium CY JUN 26-29, 2016 CL Lexington, KY DE Sprague Dawley rat; drug therapy; penetrating TBI; Morris water maze; rotarod C1 [Caudle, Krista; Sun, Justin; Pedersen, Rebecca; Hahn, Justin; Okada-Rising, Starlyn; Pandya, Jignesh; Shear, Deborah] Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL 1 PY 2016 VL 33 IS 13 MA PSB-321 BP A127 EP A128 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DP2QY UT WOS:000378336200349 ER PT J AU DeDominicis, K Mountney, A Wilson, C Jones, S Jaiswal, S Deng-Bryant, Y Braverman, S Hwang, H Hahn, J Hoy, A Dardzinski, B Shear, D Selwyn, R Cartagena, C AF DeDominicis, Kristen Mountney, Andrea Wilson, Colin Jones, Scott Jaiswal, Shalini Deng-Bryant, Ying Braverman, Stephanie Hwang, Hye Hahn, Justin Hoy, Andrew Dardzinski, Bernard Shear, Deborah Selwyn, Reed Cartagena, Casandra TI LONGITUDINAL FDG UPTAKE CHANGES FOLLOWING MILD CONCUSSIVE BRAIN INJURIES AND CORRELATION TO CLINICAL MTBI ASSESSORS IN RATS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 34th Annual National Neurotrauma Symposium CY JUN 26-29, 2016 CL Lexington, KY DE projectile concussive impact; FDG-PET; gait analysis; single injury; repeat injury C1 [DeDominicis, Kristen; Mountney, Andrea; Deng-Bryant, Ying; Braverman, Stephanie; Hwang, Hye; Hahn, Justin; Shear, Deborah; Cartagena, Casandra] Walter Reed Army Inst Res, Silver Spring, MD USA. [Wilson, Colin; Jones, Scott; Jaiswal, Shalini; Hoy, Andrew; Dardzinski, Bernard] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Selwyn, Reed] Univ New Mexico, Albuquerque, NM 87131 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL 1 PY 2016 VL 33 IS 13 MA PSA-075 BP A39 EP A40 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DP2QY UT WOS:000378336200104 ER PT J AU DeDominicis, K Hwang, H Deng-Bryant, Y Shear, D Boutte, A Cartagena, C AF DeDominicis, Kristen Hwang, Hye Deng-Bryant, Ying Shear, Deborah Boutte, Angela Cartagena, Casandra TI REGIONAL ACUTE AND SUBACUTE ALTERATIONS IN GFAP, SPECTRIN, AND BREAKDOWN PRODUCTS FOLLOWING PENETRATING BALLISTIC-LIKE TBI IN RATS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 34th Annual National Neurotrauma Symposium CY JUN 26-29, 2016 CL Lexington, KY DE GFAP; GFAP break down products; spectrin; spectrin break down products; PBBI C1 [DeDominicis, Kristen; Hwang, Hye; Deng-Bryant, Ying; Shear, Deborah; Boutte, Angela; Cartagena, Casandra] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL 1 PY 2016 VL 33 IS 13 MA PSA-009 BP A16 EP A17 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DP2QY UT WOS:000378336200040 ER PT J AU DeDominicis, K Hwang, H Deng-Bryant, Y Shear, D Boutte, A Cartagena, C AF DeDominicis, Kristen Hwang, Hye Deng-Bryant, Ying Shear, Deborah Boutte, Angela Cartagena, Casandra TI LONGITUDINAL CHANGES IN BAX AND BCL-2 IN KEY REGIONS OF INTEREST FOLLOWING PENETRATING TRAUMATIC BRAIN INJURY IN RATS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 34th Annual National Neurotrauma Symposium CY JUN 26-29, 2016 CL Lexington, KY DE BAX; Bcl-2; apoptotic factors; PBBI C1 [DeDominicis, Kristen; Hwang, Hye; Deng-Bryant, Ying; Shear, Deborah; Boutte, Angela; Cartagena, Casandra] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL 1 PY 2016 VL 33 IS 13 MA PSA-010 BP A17 EP A17 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DP2QY UT WOS:000378336200041 ER PT J AU DeMar, J Rosenberger, J Batuure, A Thadieo, D Wilder, D Mccuistion, M Foley, L Kochanek, P Hitchens, K Long, J AF DeMar, James Rosenberger, John Batuure, Andrew Thadieo, Daniel Wilder, Donna Mccuistion, Meghan Foley, Lesley Kochanek, Patrick Hitchens, Kevin Long, Joseph TI CHARACTERIZATION OF INFLAMMATION PROCESSES IN THE VISUAL SYSTEM OF RATS INDUCED BY EXPOSURE TO PRIMARY BLAST WAVES SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 34th Annual National Neurotrauma Symposium CY JUN 26-29, 2016 CL Lexington, KY DE blast wave; rat; neuroinflammation; retina; brain; omega-3 polyunsaturated fatty acid C1 [DeMar, James; Rosenberger, John; Batuure, Andrew; Thadieo, Daniel; Wilder, Donna; Mccuistion, Meghan; Long, Joseph] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci Res, Silver Spring, MD USA. [Foley, Lesley; Kochanek, Patrick; Hitchens, Kevin] Univ Pittsburgh, Anim Imaging Ctr, Pittsburgh, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL 1 PY 2016 VL 33 IS 13 MA PSB-211 BP A88 EP A88 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DP2QY UT WOS:000378336200240 ER PT J AU Deng-Bryant, Y Leung, LY Pandya, J Yang, WH Gilsdorf, J Shear, D AF Deng-Bryant, Ying Leung, Lai Yee Pandya, Jignesh Yang, Weihong Gilsdorf, Janice Shear, Deborah TI GLOBAL METABOLOMICS ANALYSIS IN RATS FOLLOWING PENETRATING BALLISTIC-LIKE BRAIN INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 34th Annual National Neurotrauma Symposium CY JUN 26-29, 2016 CL Lexington, KY DE metabolomics; penetrating ballistic-like brain injury C1 [Deng-Bryant, Ying; Leung, Lai Yee; Pandya, Jignesh; Yang, Weihong; Gilsdorf, Janice; Shear, Deborah] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL 1 PY 2016 VL 33 IS 13 MA PSA-117 BP A54 EP A54 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DP2QY UT WOS:000378336200145 ER PT J AU Haghighi, F Carr, W LoPresti, M Yarnell, A Karmakar, M Mendelev, N Umali, M McCarron, R Elder, G Ahlers, S AF Haghighi, Fatemeh Carr, Walter LoPresti, Matthew Yarnell, Angela Karmakar, Moumita Mendelev, Natalia Umali, Michelle McCarron, Richard Elder, Gregory Ahlers, Stephen TI EPIGENETIC AND TRANSCRIPTIONAL SIGNATURES OF BLAST EXPOSURE SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 34th Annual National Neurotrauma Symposium CY JUN 26-29, 2016 CL Lexington, KY DE epigenetics; methylation; blast C1 [Haghighi, Fatemeh; Karmakar, Moumita; Mendelev, Natalia] Icahn Sch Med Mt Sinai, Neurosci, New York, NY 10029 USA. [Haghighi, Fatemeh; Umali, Michelle; Elder, Gregory] James J Peters VA Med Ctr, Med Epigen, New York, NY USA. [Carr, Walter; LoPresti, Matthew; Yarnell, Angela] Walter Reed Army Inst Res, Rockville, MD USA. [McCarron, Richard; Ahlers, Stephen] Naval Med Res Ctr, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL 1 PY 2016 VL 33 IS 13 MA PSB-183 BP A78 EP A78 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DP2QY UT WOS:000378336200212 ER PT J AU Leung, LY Cardiff, K Yang, XF Wilfred, B Deng-Bryant, Y Tortella, F Shear, D AF Leung, Lai Yee Cardiff, Katherine Yang, Xiaofang Wilfred, Bernard Deng-Bryant, Ying Tortella, Frank Shear, Deborah TI CARDIAC BAROREFLEX RESPONSES IN A RAT MODEL OF PENETRATING BALLISTIC-LIKE BRAIN INJURY (PBBI) WITH HYPOXEMIA AND HEMORRHAGIC SHOCK SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 34th Annual National Neurotrauma Symposium CY JUN 26-29, 2016 CL Lexington, KY DE polytrauma; cardiac response; baroreflex sensitivity; hypoxemia; hemorrhagic shock C1 [Leung, Lai Yee; Cardiff, Katherine; Yang, Xiaofang; Wilfred, Bernard; Deng-Bryant, Ying; Tortella, Frank; Shear, Deborah] Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL 1 PY 2016 VL 33 IS 13 MA PSB-337 BP A133 EP A133 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DP2QY UT WOS:000378336200365 ER PT J AU Lu, XCM Cao, Y Liao, ZL Whiteman, A Tortella, F Shear, D AF Lu, Xi-Chun May Cao, Ying Liao, Zhilin Whiteman, Ashley Tortella, Frank Shear, Deborah TI TIME-COURSE PROFILE OF EEG ABNORMALITY FOLLOWING REPEATED CONCUSSIVE BRAIN INJURY DETECTED BY QEEG POWER SPECTRAL ANALYSIS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 34th Annual National Neurotrauma Symposium CY JUN 26-29, 2016 CL Lexington, KY DE EEG power spectrum analysis; repeated concussive brain injury C1 [Lu, Xi-Chun May; Cao, Ying; Liao, Zhilin; Whiteman, Ashley; Tortella, Frank; Shear, Deborah] Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat Psychia, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL 1 PY 2016 VL 33 IS 13 MA PSB-251 BP A103 EP A103 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DP2QY UT WOS:000378336200280 ER PT J AU Lu, XCM Tallarida, R Cao, Y Liao, ZL Browning, J Whiteman, A Mountney, A Shear, D Tortella, F AF Lu, Xi-Chun May Tallarida, Ronald Cao, Ying Liao, Zhilin Browning, Jenny Whiteman, Ashley Mountney, Andrea Shear, Deborah Tortella, Frank TI SYNERGISTIC EFFECTS OF PHENYTOIN AND LEVETIRACETAM COMBINATION THERAPY ON ATTENUATION POST-TRAUMATIC NONCONVULSIVE SEIZURES SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 34th Annual National Neurotrauma Symposium CY JUN 26-29, 2016 CL Lexington, KY DE post-traumatic nonconvulsive seizures; phenytoin; levetiracetam; combination therapy; isobolographic analysis; synergism C1 [Lu, Xi-Chun May; Cao, Ying; Liao, Zhilin; Browning, Jenny; Whiteman, Ashley; Mountney, Andrea; Shear, Deborah; Tortella, Frank] Walter Reed Army Inst Res, Silver Spring, MD USA. [Tallarida, Ronald] Temple Univ, Philadelphia, PA 19122 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL 1 PY 2016 VL 33 IS 13 MA PSB-259 BP A105 EP A106 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DP2QY UT WOS:000378336200288 ER PT J AU Lu, XCM Cao, Y Liao, ZL Mountney, A Browning, J Shear, D Tortella, F AF Lu, Xi-Chun May Cao, Ying Liao, Zhilin Mountney, Andrea Browning, Jenny Shear, Deborah Tortella, Frank TI DOSE RESPONSE EFFECTS OF SIMVASTATIN ON ATTENUATION OF NONCONVULSIVE SEIZURES INDUCED BY PENETRATING BALLISTIC-LIKE BRAIN INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 34th Annual National Neurotrauma Symposium CY JUN 26-29, 2016 CL Lexington, KY DE post-traumatic nonconvulsive seizures; simvastatin; penetrating brain injury C1 [Lu, Xi-Chun May; Cao, Ying; Liao, Zhilin; Mountney, Andrea; Browning, Jenny; Shear, Deborah; Tortella, Frank] Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat Psychia, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL 1 PY 2016 VL 33 IS 13 MA PSA-084 BP A43 EP A43 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DP2QY UT WOS:000378336200113 ER PT J AU Mondello, S Shear, DA Bramlett, HM Dixon, CE Dietrich, WD Wang, K Hayes, R Tortella, FC Kochanek, PM AF Mondello, Stefania Shear, Deborah A. Bramlett, Helen M. Dixon, C. Edward Dietrich, W. Dalton Wang, Kevin Hayes, Ronald Tortella, Frank C. Kochanek, Patrick M. TI TIME COURSE OF BRAIN INJURY BIOMARKERS ACROSS TBI MODELS: FINDINGS FROM OPERATION BRAIN TRAUMA THERAPY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 34th Annual National Neurotrauma Symposium CY JUN 26-29, 2016 CL Lexington, KY DE UCH-L1; GFAP; animal models; CCI; FPI; PBBI C1 [Mondello, Stefania] Univ Messina, Messina, Italy. [Shear, Deborah A.; Tortella, Frank C.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Bramlett, Helen M.; Dietrich, W. Dalton] Univ Miami, Miami, FL USA. [Dixon, C. Edward; Kochanek, Patrick M.] Safar Ctr Resuscitat Res, Pittsburgh, PA USA. [Dixon, C. Edward; Kochanek, Patrick M.] Univ Pittsburgh, Pittsburgh, PA USA. [Wang, Kevin] Univ Florida, Gainesville, FL USA. [Hayes, Ronald] Banyan Biomarkers, Alachua, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL 1 PY 2016 VL 33 IS 13 MA PSB-196 BP A83 EP A83 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DP2QY UT WOS:000378336200225 ER PT J AU Mountney, A Dougherty, J Flerlage, W Rho, C Sanjakdar, S Balkin, T Tortella, F Shear, D AF Mountney, Andrea Dougherty, Jacqueline Flerlage, William Rho, Chanyang Sanjakdar, Sarah Balkin, Thomas Tortella, Frank Shear, Deborah TI CAFFEINE PRE-TREATMENT ALTERS TBI-INDUCED SLEEP DISRUPTIONS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 34th Annual National Neurotrauma Symposium CY JUN 26-29, 2016 CL Lexington, KY DE caffeine; sleep; EEG; REM C1 [Mountney, Andrea; Dougherty, Jacqueline; Flerlage, William; Rho, Chanyang; Sanjakdar, Sarah; Balkin, Thomas; Tortella, Frank; Shear, Deborah] Walter Reed Army Inst Res, BTNN, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL 1 PY 2016 VL 33 IS 13 MA PSB-338 BP A133 EP A134 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DP2QY UT WOS:000378336200366 ER PT J AU Mountney, A Dougherty, J Flerlage, J Rho, C Balkin, T Shear, D Tortella, F AF Mountney, Andrea Dougherty, Jacqueline Flerlage, Jesse Rho, Chanyang Balkin, Tom Shear, Deborah Tortella, Frank TI PENETRATING BRAIN INJURY ALTERS SLEEP-WAKE ARCHITECTURE IN RODENTS SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 34th Annual National Neurotrauma Symposium CY JUN 26-29, 2016 CL Lexington, KY DE PBBI; REM; qEEG C1 [Mountney, Andrea; Dougherty, Jacqueline; Flerlage, Jesse; Rho, Chanyang; Balkin, Tom; Shear, Deborah; Tortella, Frank] BTNN, Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL 1 PY 2016 VL 33 IS 13 MA PSA-081 BP A41 EP A42 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DP2QY UT WOS:000378336200110 ER PT J AU Okada-Rising, S Pedersen, R Sun, J Browning, J Gilsdorf, J Tortella, F Mondello, S Shear, D AF Okada-Rising, Starlyn Pedersen, Rebecca Sun, Justin Browning, Jenny Gilsdorf, Janice Tortella, Frank Mondello, Stefania Shear, Deborah TI DOSE-RESPONSE EVALUATION OF AMANTADINE IN THE WRAIR PBBI MODEL: STUDIES FROM THE OPERATION BRAIN TRAUMA THERAPY (OBTT) CONSORTIUM SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 34th Annual National Neurotrauma Symposium CY JUN 26-29, 2016 CL Lexington, KY DE traumatic brain injury; OBTT; behavior C1 [Okada-Rising, Starlyn; Pedersen, Rebecca; Sun, Justin; Browning, Jenny; Gilsdorf, Janice; Tortella, Frank; Shear, Deborah] Walter Reed Army Inst Res, BTNN, Silver Spring, MD USA. [Mondello, Stefania] Univ Messina, Neurosci, Messina, Italy. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL 1 PY 2016 VL 33 IS 13 MA PSB-320 BP A127 EP A127 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DP2QY UT WOS:000378336200348 ER PT J AU Pandya, J Leung, LY Yang, XF Shear, D Deng-Bryant, Y AF Pandya, Jignesh Leung, Lai Yee Yang, Xiaofang Shear, Deborah Deng-Bryant, Ying TI IDENTIFICATION OF PREFERRED SUBSTRATES OF MITOCHONDRIAL ENERGY METABOLISM FOLLOWING PENETRATING BALLISTIC-LIKE BRAIN INJURY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 34th Annual National Neurotrauma Symposium CY JUN 26-29, 2016 CL Lexington, KY DE mitochondrial bioenergetics; preferred metabolic substrates; penetrating ballistic-like brain injury; alternative biofuels C1 [Pandya, Jignesh; Leung, Lai Yee; Yang, Xiaofang; Shear, Deborah; Deng-Bryant, Ying] Walter Reed Army Inst Res, BTNN, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL 1 PY 2016 VL 33 IS 13 MA PSB-293 BP A118 EP A118 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DP2QY UT WOS:000378336200322 ER PT J AU Sanjakdar, S Flerlage, W Yang, W Flores, AH Kang, HS Balkin, T Tortella, F Shear, D Mountney, A AF Sanjakdar, Sarah Flerlage, William Yang, Weihong Flores, Alondra Kang, Hyun Sik Balkin, Thomas Tortella, Frank Shear, Deborah Mountney, Andrea TI EVALUATION OF ACUTE AND CHRONIC CAFFEINE PRE-EXPOSURE IN THE WRAIR PENETRATING BALLISTIC-LIKE BRAIN INJURY MODEL SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 34th Annual National Neurotrauma Symposium CY JUN 26-29, 2016 CL Lexington, KY DE TBI; caffeine; brain injury; rat; behavior C1 [Sanjakdar, Sarah; Flerlage, William; Yang, Weihong; Flores, Alondra; Kang, Hyun Sik; Balkin, Thomas; Tortella, Frank; Shear, Deborah; Mountney, Andrea] Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL 1 PY 2016 VL 33 IS 13 MA PSB-184 BP A78 EP A79 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DP2QY UT WOS:000378336200213 ER PT J AU Wang, Y Su, Y Wei, YL Wilder, D Arun, P Gist, I Long, J AF Wang, Ying Su, Yan Wei, Yanling Wilder, Donna Arun, Peethambaran Gist, Irene Long, Joseph TI ELEVATED EXPRESSION OF P21(CIP1) IN BLAST NEUROTRAUMA MIGHT CONTRIBUTE TO BLAST-INDUCED TAUOPATHY SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 34th Annual National Neurotrauma Symposium CY JUN 26-29, 2016 CL Lexington, KY DE blast neurotrauma; p21(Cip1); p-Tau; tauopathy C1 [Wang, Ying; Su, Yan; Wei, Yanling; Wilder, Donna; Arun, Peethambaran; Gist, Irene; Long, Joseph] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL 1 PY 2016 VL 33 IS 13 MA PSA-036 BP A25 EP A26 PG 2 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA DP2QY UT WOS:000378336200066 ER PT J AU Barry, BE Ohland, MW Mumford, KJ Long, RA AF Barry, Brock E. Ohland, Matthew W. Mumford, Kevin J. Long, Russell A. TI Influence of Job Market Conditions on Engineering Cooperative Education Participation SO JOURNAL OF PROFESSIONAL ISSUES IN ENGINEERING EDUCATION AND PRACTICE LA English DT Article DE Cooperative education; Predictive modeling; Student ability; Wage rate AB Cooperative education (co-op) is a program in which participating students typically alternate between full-time study and paid full-time employment. Choosing to participate in a co-op program usually delays the student's graduation by up to one year, but may increase the student's job market prospects. This paper attempts to estimate the response of co-op participation to the engineering field-specific average wage for recent graduates. A relationship between wage growth, student ability, and co-op participation is investigated. Predictive modeling was performed using data obtained from the Multiple-Institution Database for Investigating Engineering Longitudinal Development (MIDFIELD), as well as the American Association of Engineering Societies (AAES) Annual Report of Engineering Salaries. Semistructured interviews were conducted with industry co-op representatives to address supply and demand related questions. The authors found that a $10,000 real increase in the average initial wage causes a 5.4% decrease in co-op program participation. In addition, there is heterogeneity in the response by student ability. C1 [Barry, Brock E.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. [Barry, Brock E.] US Mil Acad, Mech Grp, West Point, NY 10996 USA. [Ohland, Matthew W.] Purdue Univ, Sch Engn Educ, W Lafayette, IN 47907 USA. [Mumford, Kevin J.] Purdue Univ, Krannert Sch Management, W Lafayette, IN 47907 USA. [Long, Russell A.] Purdue Univ, Sch Engn Educ, Project Assessment, W Lafayette, IN 47907 USA. RP Barry, BE (reprint author), US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA.; Barry, BE (reprint author), US Mil Acad, Mech Grp, West Point, NY 10996 USA. EM brock.barry@usma.edu OI Ohland, Matthew/0000-0003-4052-1452 NR 20 TC 0 Z9 0 U1 7 U2 8 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1052-3928 EI 1943-5541 J9 J PROF ISS ENG ED PR JI J. Prof. Issues Eng. Educ. Pract. PD JUL PY 2016 VL 142 IS 3 AR 04015017 DI 10.1061/(ASCE)EI.1943-5541.0000270 PG 8 WC Education, Scientific Disciplines; Engineering, Multidisciplinary SC Education & Educational Research; Engineering GA DQ0AW UT WOS:000378860500005 ER PT J AU Zhang, J Chen, Y Ponting, B Gebremichael, E Magana, R Maxwell, G Dubinskii, M AF Zhang, J. Chen, Y. Ponting, B. Gebremichael, E. Magana, R. Maxwell, G. Dubinskii, M. TI Highly efficient waveguided laser performance of diode pumped unclad Yb:YAG crystalline fibre SO LASER PHYSICS LETTERS LA English DT Article DE fibre laser; diode-pumped laser; crystalline fibre; waveguided propagation ID DOUBLE-CLAD; YAG AB Single crystal fibre (SCF), as most often used in the literature today, is the term referring to a relatively thin (under 1 mm diameter) and pretty short (30-60 mm long), unclad single-crystalline rod surrounded by air, in a laser configuration where the pump power is waveguided by the total internal reflection of the cylindrical circumference. In previous reports on SCF lasers the pump is flood-illuminating the volume of the gain medium, while the generated laser signal is in a free propagation mode inside the laser rod, i.e. the laser mode structure is defined solely by the external cavity mirror configuration. Presented here are the experimental laser results obtained with the diode-pumped, 100 mu m diameter, 100 mm long, unclad Yb:YAG crystalline fibre, wherein both pump light and generated laser power are waveguided. To the best of our knowledge, the demonstrated laser operation is based on the thinnest and the longest unclad fibre reported so far. It is also believed to be the first reported true waveguided laser operation from an unclad single crystalline fibre. Laser efficiency of over 58% obtained with no antireflective coatings on fibre ends is a manifestation of low composite loss figure, inclusive of both material bulk and waveguiding loss. C1 [Zhang, J.; Chen, Y.; Dubinskii, M.] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Ponting, B.; Gebremichael, E.; Magana, R.; Maxwell, G.] Shasta Crystals Inc, 1750 Cesar Chavez St,Ste J, San Francisco, CA 94124 USA. RP Dubinskii, M (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM mark.dubinskiy.civ@mail.mil NR 14 TC 2 Z9 2 U1 5 U2 8 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 1612-2011 EI 1612-202X J9 LASER PHYS LETT JI Laser Phys. Lett. PD JUL PY 2016 VL 13 IS 7 AR 075101 DI 10.1088/1612-2011/13/7/075101 PG 4 WC Optics; Physics, Applied SC Optics; Physics GA DP9VL UT WOS:000378845600001 ER PT J AU Becker, R Lloyd, JT AF Becker, R. Lloyd, J. T. TI A reduced-order crystal model for HCP metals: Application to Mg SO MECHANICS OF MATERIALS LA English DT Article DE Crystal plasticity; Twinning; Magnesium; HCP ID PLANE-STRAIN COMPRESSION; MAGNESIUM ALLOY AZ31B; POLYCRYSTAL PLASTICITY; CRYSTALLOGRAPHIC TEXTURE; SHEAR LOCALIZATION; SINGLE-CRYSTAL; FCC METALS; DEFORMATION; SIMULATION; ANISOTROPY AB A computationally efficient plasticity model for HCP crystals is developed for use in simulations where the constitutive model evaluations account for a significant fraction of the total analysis time. Combined pyramidal and prismatic slip is represented as an isotropic function while slip along the basal plane and extension twinning are maintained as distinct mechanisms. Additional efficiency is gained by deferring the updates of the rate-independent twinning and basal system strengths until the following time step, which allows precomputation of the inverses of the slip interaction matrices. Comparisons are made with single crystal pure Mg experimental data, as well as rolled polycrystal AZ31B data. The computational efficiency is evaluated by comparing simulation times from the current model with J2-Flow theory plasticity and a full crystal plasticity model. The reduced crystal plasticity model retains essential crystallographic features that govern macroscale mechanical response of HCP metals at approximately five times the computational expense of a J2-Flow theory calculation. Published by Elsevier Ltd. C1 [Becker, R.; Lloyd, J. T.] US Army, Impact Phys Branch, RDRL WMP C, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Becker, R (reprint author), US Army, Impact Phys Branch, RDRL WMP C, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM richard.c.becker.civ@mail.mil FU US Army Research Laboratory FX The authors would like to thank Dr. Daniel Casem for supplying the AZ31B compression data and the US Army Research Laboratory for supporting this work. Approved for public release: distribution is unlimited. NR 45 TC 1 Z9 1 U1 12 U2 17 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-6636 EI 1872-7743 J9 MECH MATER JI Mech. Mater. PD JUL PY 2016 VL 98 BP 98 EP 110 DI 10.1016/j.mechmat.2016.04.009 PG 13 WC Materials Science, Multidisciplinary; Mechanics SC Materials Science; Mechanics GA DP4LL UT WOS:000378467300009 ER PT J AU McGann, P Snesrud, E Maybank, R Corey, B Ong, AC Clifford, R Hinkle, M Whitman, T Lesho, E Schaecher, KE AF McGann, Patrick Snesrud, Erik Maybank, Rosslyn Corey, Brendan Ong, Ana C. Clifford, Robert Hinkle, Mary Whitman, Timothy Lesho, Emil Schaecher, Kurt E. TI Escherichia coli Harboring mcr-1 and bla(CTX-M) on a Novel IncF Plasmid: First Report of mcr-1 in the United States SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Letter C1 [McGann, Patrick; Snesrud, Erik; Maybank, Rosslyn; Corey, Brendan; Ong, Ana C.; Clifford, Robert; Hinkle, Mary; Lesho, Emil] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD USA. [Whitman, Timothy] Walter Reed Natl Mil Med Ctr, Dept Infect Dis, Bethesda, MD USA. [Schaecher, Kurt E.] Walter Reed Natl Mil Med Ctr, Dept Pathol, Bethesda, MD USA. RP McGann, P (reprint author), Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD USA.; Schaecher, KE (reprint author), Walter Reed Natl Mil Med Ctr, Dept Pathol, Bethesda, MD USA. EM patrick.t.mcgann4.civ@mail.mil; kurt.e.schaecher.mil@mail.mil NR 10 TC 53 Z9 53 U1 2 U2 7 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD JUL PY 2016 VL 60 IS 7 BP 4420 EP 4421 DI 10.1128/AAC.01103-16 PG 2 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA DO9GW UT WOS:000378094400078 PM 27230792 ER PT J AU Lewis, C Valenciano, M Cornwell, C AF Lewis, Christopher Valenciano, Miguel Cornwell, Charles TI Visualizations of molecular dynamics simulations of high-performance polycrystalline structural ceramics SO PARALLEL COMPUTING LA English DT Article DE Visualization; High Performance Computing; Molecular Dynamics; Polycrystalline Structural Ceramics; LAMMPS; VTK ID NACRE; BONE; NANOCOMPOSITES; COMPOSITES; TOUGHNESS; DESIGN AB Initiated by the Department of Defense (DOD) High Performance Computing Modernization Program (HPCMP), the Data Analysis and Assessment Center (DAAC), serves the needs of DOD HPCMP scientists by facilitating the analysis of an ever-increasing volume and complexity of data [1]. A research scientist and HPCMP user ran nanoscale molecular dynamics simulations using Large-scale Atomic/Molecular Massively Parallel Simulator code (LAMMPS) from Sandia National Labs. The largest simulation contained over 70 million atoms (Fig. 7). Data sets this large are required to study crack propagation and failure mechanisms that span multiple length scales with atomic resolution. The DAAC developed new methods to visualize the time evolution of data sets this large. The size and complexity of the molecular dynamics simulations and the analytics required the use of DOD HPCMP High Performance Computing (HPC) resources. Published by Elsevier B.V. C1 [Lewis, Christopher; Valenciano, Miguel] DAAC, Dept Def High Performance Comp Modernizat Program, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. [Cornwell, Charles] US Army Engineer Res & Dev Ctr ERDC, CAB, ITL, Vicksburg, MS USA. RP Lewis, C (reprint author), DAAC, Dept Def High Performance Comp Modernizat Program, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Christopher.D.Lewis@erdc.dren.mil; Miguel.A.Valenciano@erdc.dren.mil; Charles.F.Cornwell@erdc.dren.mil FU Nanoscale Studies of Polycrystalline Materials with Emphasis on Ceramic Synthesis; Effects of Grain Boundaries on Ceramic Properties FX This research was performed as part of the U.S. Army Engineer Research and Development Center's Advanced Material Initiative. In particular, the authors gratefully acknowledge the funding support from the research programs: "Nanoscale Studies of Polycrystalline Materials with Emphasis on Ceramic Synthesis" and "Effects of Grain Boundaries on Ceramic Properties." We thank the Chief of Engineers of the U.S. Army Corps of Engineers for permission to publish this article. The authors would also like to thank the Department of Defense High Performance Computing Modernization Program for providing the necessary resources that made this research possible. NR 23 TC 0 Z9 0 U1 6 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-8191 EI 1872-7336 J9 PARALLEL COMPUT JI Parallel Comput. PD JUL PY 2016 VL 55 SI SI BP 35 EP 42 DI 10.1016/j.parco.2015.10.008 PG 8 WC Computer Science, Theory & Methods SC Computer Science GA DP4KG UT WOS:000378464200006 ER PT J AU Barham, DW DeRosa, R Pederson, AM Freeman, JH Rooks, VJ McMann, LP AF Barham, David W. DeRosa, Raffaella Pederson, Anita M. Freeman, Judy H. Rooks, Veronica J. McMann, Leah P. TI Ovotesticular Disorders of Sexual Development: A Case of Hernia Uteri Inguinalis SO UROLOGY LA English DT Article ID CLASSIFICATION AB Ovotesticular disorders of sexual development result in the presence of both testis and ovarian tissue. Most commonly, gonadal structures in the scrotum or inguinal canal are comprised of testis tissue. The presence of a uterus within an inguinal hernia sac in a phenotypically male patient is referred to as hernia uteri inguinalis. This condition has rarely been reported in patients with ovotesticular disorders of sexual development. We present a patient with rare mosaicism in combination with an unusual location of Mullerian duct structures within an inguinal hernia sac. Published by Elsevier Inc. C1 [DeRosa, Raffaella] Tripler Army Med Ctr, Dept Surg, Div Urol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. Tripler Army Med Ctr, Dept Pediat, 1 Jarrett White Rd, Honolulu, HI 96859 USA. Tripler Army Med Ctr, Dept Pathol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. Tripler Army Med Ctr, Dept Radiol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. RP DeRosa, R (reprint author), Tripler Army Med Ctr, Dept Surg, Div Urol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM Raffaella.Derosa.mil@mail.mil NR 8 TC 0 Z9 0 U1 2 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-4295 EI 1527-9995 J9 UROLOGY JI Urology PD JUL PY 2016 VL 93 BP 194 EP 196 DI 10.1016/j.urology.2016.02.019 PG 3 WC Urology & Nephrology SC Urology & Nephrology GA DP3EB UT WOS:000378374100059 PM 27015943 ER PT J AU Livingston, CJ Freeman, RJ Mohammad, A Costales, VC Titus, TM Harvey, BJ Sherin, KM AF Livingston, Catherine J. Freeman, Randall J. Mohammad, Amir Costales, Victoria C. Titus, Tisha M. Harvey, Bart J. Sherin, Kevin M. CA Choosing Wiselys Task Force TI Choosing Wisely (R) in Preventive Medicine The American College of Preventive Medicine's Top 5 List of Recommendations SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID SERVICES TASK-FORCE; PROSTATE-CANCER; CLINICAL GUIDELINES; HEALTH-CARE; DIETARY-SUPPLEMENTS; COST-EFFECTIVENESS; FOLLOW-UP; PHYSICIANS; MEDICARE; STATEMENT AB The ChoosingWisely (R) initiative is a national campaign led by the American Board of Internal Medicine Foundation, focused on quality improvement and advancing a dialogue on avoiding wasteful or unnecessary medical tests, procedures, and treatments. The American College of Preventive Medicine (ACPM) Prevention Practice Committee is an active participant in the Choosing Wisely project. The committee created the ACPM Choosing Wisely Task Force to lead the development of ACPM's recommendations with the intention of facilitating wise decisions about the appropriate use of preventive care. After utilizing an iterative process that involved reviewing evidence-based literature, the ACPM Choosing Wisely Task Force developed five recommendations targeted toward overused services within the field of preventive medicine. These include: (1) don't take a multivitamin, vitamin E, or beta carotene to prevent cardiovascular disease or cancer; (2) don't routinely perform prostate-specific antigen-based screening for prostate cancer; (3) don't use whole-body scans for early tumor detection in asymptomatic patients; (4) don't use expensive medications when an equally effective and lower-cost medication is available; and (5) don't perform screening for cervical cancer in low-risk women aged 65 years or older and in women who have had a total hysterectomy for benign disease. The Task Force also reviewed some of the barriers to implementing these recommendations, taking into account the interplay between system and environmental characteristics, and identified specific strategies necessary for timely utilization of these recommendations. (C) 2016 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved. C1 [Livingston, Catherine J.] Oregon Hlth & Sci Univ, 3930 SE Div St, Portland, OR 97202 USA. [Freeman, Randall J.] US Army, Human Resources Command, Ft Knox, KY USA. [Mohammad, Amir] Yale Univ, Sch Med, VA Connecticut HCS, New Haven, CT USA. [Costales, Victoria C.] New York City Dept Hlth, New York, NY 10013 USA. [Titus, Tisha M.] Atlanta VA Med Ctr, Decatur, GA USA. [Harvey, Bart J.] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada. [Sherin, Kevin M.] Univ Cent Florida, Florida State Univ, Coll Med, Orlando, FL 32816 USA. RP Livingston, CJ (reprint author), Oregon Hlth & Sci Univ, Family Med Richmond, 3930 SE Div St, Portland, OR 97202 USA. EM livingsc@ohsu.edu NR 46 TC 2 Z9 2 U1 6 U2 8 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 EI 1873-2607 J9 AM J PREV MED JI Am. J. Prev. Med. PD JUL PY 2016 VL 51 IS 1 BP 141 EP 149 DI 10.1016/j.amepre.2016.03.009 PG 9 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA DO8VR UT WOS:000378063800020 PM 27155735 ER PT J AU Breton, DJ Baker, I Cole, DM AF Breton, Daniel J. Baker, Ian Cole, David M. TI Microstructural evolution of polycrystalline ice during confined creep testing SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article DE Creep; Dislocation; Electron backscatter diffraction; Grain boundary; Stacking fault; Polycrystalline ice ID HIGH-TEMPERATURE CREEP; STEADY-STATE CREEP; HYDROSTATIC-PRESSURE; PLASTIC-DEFORMATION; EDGE DISLOCATIONS; GRAIN-BOUNDARIES; SINGLE-CRYSTALS; PURE METALS; CROSS-SLIP; RECRYSTALLIZATION AB The mechanical properties of polycrystalline ice I-h have been observed to change under an applied hydrostatic pressure comparable to that present near the bottom, of kilometer-thick ice sheets. To help determine the cause of these changes, we conducted confined creep testing of laboratory-prepared polycrystalline ice at pressures up to 20 MPa (equivalent to similar to 2000 m of overburden) and subsequent microstructural analysis of specimens deformed by creep using optical microscopy and scanning electron microscopy, including extensive electron backscatter diffraction mapping of crystal orientations. Microstructural observations of the creep-deformed specimens revealed smaller median grain sizes, less regular, and more interlocked grain shapes in specimens deformed at higher pressure compared with those deformed at atmospheric pressure. Variable pressure testing reveals little change in strain rate for pressures less than 15 MPa, leading to alternative hypotheses regarding the influence of confining pressure on the dislocation dynamics and associated creep behavior of polycrystalline ice. Our central hypothesis is that widely dissociated basal dislocations in ice begin to constrict after the confining pressure reaches a critical value. This critical pressure depends strongly on the (currently unknown) lattice dilatation induced in ice by the presence of stacking faults. Published by Elsevier B.V. C1 [Breton, Daniel J.; Cole, David M.] Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. [Baker, Ian] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. RP Breton, DJ (reprint author), Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM daniel.j.breton@usace.army.mil FU NSF [PLR 1022703] FX This work was supported by NSF Award PLR 1022703, "Strain-Induced Fabric Development in Ice Under Hydrostatic Pressure". The authors would like to acknowledge the efforts of two anonymous reviewers whose commentary and feedback greatly improved the focus of this paper. We also extend our thanks to Professor T. Hondoh for the helpful comments and discussion. The authors are also grateful to D. Punt and C. Donnelly of ERDC-CRREL for their invaluable assistance with data acquisition, mechanical and hydraulic systems in support of this work. Permission to publish was granted by Director, Cold Regions Research and Engineering Laboratory. NR 75 TC 0 Z9 0 U1 4 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X EI 1872-7441 J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD JUL PY 2016 VL 127 BP 25 EP 36 DI 10.1016/j.coldregions.2016.03.009 PG 12 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA DO5ME UT WOS:000377826400004 ER PT J AU Trautmann, L AF Trautmann, Lydie TI Kill: boosting HIV-specific immune responses SO CURRENT OPINION IN HIV AND AIDS LA English DT Review DE HIV-specific CD8(+) T cells; immunobased therapies; posttreatment control of HIV replication ID CD8(+) T-CELLS; ACTIVE ANTIRETROVIRAL THERAPY; HISTONE DEACETYLASE INHIBITORS; HIGHLY PATHOGENIC SIV; EX-VIVO; IN-VIVO; VIRUS-REPLICATION; LATENT HIV-1; TREATMENT INTERRUPTION; INFECTED INDIVIDUALS AB Purpose of review Increasing evidence suggests that purging the latent HIV reservoir in virally suppressed individuals will require both the induction of viral replication from its latent state and the elimination of these reactivated HIV-infected cells ('Shock and Kill' strategy). Boosting potent HIV-specific CD8(+) T cells is a promising way to achieve an HIV cure. Recent findings Recent studies provided the rationale for developing immune interventions to increase the numbers, function and location of HIV-specific CD8(+) T cells to purge HIV reservoirs. Multiple approaches are being evaluated including very early suppression of HIV replication in acute infection, adoptive cell transfer, therapeutic vaccination or use of immunomodulatory molecules. New assays to measure the killing and antiviral function of induced HIV-specific CD8(+) T cells have been developed to assess the efficacy of these new approaches. The strategies combining HIV reactivation and immunobased therapies to boost HIV-specific CD8(+) T cells can be tested in in-vivo and in-silico models to accelerate the design of new clinical trials. Summary New immunobased strategies are explored to boost HIV-specific CD8(+) T cells able to purge the HIV-infected cells with the ultimate goal of achieving spontaneous control of viral replication without antiretroviral treatment. C1 [Trautmann, Lydie] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Trautmann, Lydie] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. RP Trautmann, L (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. EM ltrautmann@hivresearch.org FU NIH [R01AI108433, R21AI116233]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; US Department of Defense (DoD) [W81XWH-07-2-0067] FX This work was supported by the following sources: NIH grant R01AI108433, R21AI116233 and a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. and the US Department of Defense (DoD). The views expressed are those of the authors and should not be construed to represent the positions of the US Army or the Department of Defense. NR 110 TC 1 Z9 1 U1 2 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1746-630X EI 1746-6318 J9 CURR OPIN HIV AIDS JI Curr. Opin. HIV AIDS PD JUL PY 2016 VL 11 IS 4 BP 409 EP 416 DI 10.1097/COH.0000000000000286 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA DO6XB UT WOS:000377925700009 PM 27054280 ER PT J AU Rosencranz, JA Ganju, NK Ambrose, RF Brosnahan, SM Dickhudt, PJ Guntenspergen, GR MacDonald, GM Takekawa, JY Thorne, KM AF Rosencranz, Jordan A. Ganju, Neil K. Ambrose, Richard F. Brosnahan, Sandra M. Dickhudt, Patrick J. Guntenspergen, Glenn R. MacDonald, Glen M. Takekawa, John Y. Thorne, Karen M. TI Balanced Sediment Fluxes in Southern California's Mediterranean-Climate Zone Salt Marshes SO ESTUARIES AND COASTS LA English DT Article DE Suspended sediment fluxes; Vertical accretion; Mediterranean climate; Tidal creeks; Salt marshes ID SEA-LEVEL RISE; SUSPENDED SEDIMENT; COASTAL WETLANDS; ACCRETION; ESTUARY; EVOLUTION; ELEVATION; RESPONSES; SENSORS; RATES AB Salt marsh elevation and geomorphic stability depends on mineral sedimentation. Many Mediterranean-climate salt marshes along southern California, USA coast import sediment during El Nio storm events, but sediment fluxes and mechanisms during dry weather are potentially important for marsh stability. We calculated tidal creek sediment fluxes within a highly modified, sediment-starved, 1.5-km(2) salt marsh (Seal Beach) and a less modified 1-km(2) marsh (Mugu) with fluvial sediment supply. We measured salt marsh plain suspended sediment concentration and vertical accretion using single stage samplers and marker horizons. At Seal Beach, a 2014 storm yielded 39 and 28 g/s mean sediment fluxes and imported 12,000 and 8800 kg in a western and eastern channel. Western channel storm imports offset 8700 kg exported during 2 months of dry weather, while eastern channel storm imports augmented 9200 kg imported during dry weather. During the storm at Mugu, suspended sediment concentrations on the marsh plain increased by a factor of four; accretion was 1-2 mm near creek levees. An exceptionally high tide sequence yielded 4.4 g/s mean sediment flux, importing 1700 kg: 20 % of Mugu's dry weather fluxes. Overall, low sediment fluxes were observed, suggesting that these salt marshes are geomorphically stable during dry weather conditions. Results suggest storms and high lunar tides may play large roles, importing sediment and maintaining dry weather sediment flux balances for southern California salt marshes. However, under future climate change and sea level rise scenarios, results suggest that balanced sediment fluxes lead to marsh elevational instability based on estimated mineral sediment deficits. C1 [Rosencranz, Jordan A.; Ambrose, Richard F.; MacDonald, Glen M.] Univ Calif Los Angeles, Inst Environm & Sustainabil, Los Angeles, CA 90095 USA. [Ganju, Neil K.; Brosnahan, Sandra M.] US Geol Survey, Woods Hole Coastal, Woods Hole, MA 02556 USA. [Ganju, Neil K.; Brosnahan, Sandra M.] US Geol Survey, Ctr Marine Sci, Woods Hole, MA 02556 USA. [Ambrose, Richard F.] Univ Calif Los Angeles, Dept Environm Hlth Sci, Los Angeles, CA 90095 USA. [Dickhudt, Patrick J.] US Army Corps Engineers, Field Res Facil, Kitty Hawk, NC 27949 USA. [Guntenspergen, Glenn R.] US Geol Survey, Patuxent Wildlife Res Ctr, Superior, WI 54880 USA. [MacDonald, Glen M.] Univ Calif Los Angeles, Dept Geog, Los Angeles, CA 90095 USA. [Rosencranz, Jordan A.; Takekawa, John Y.; Thorne, Karen M.] US Geol Survey, Western Ecol Res Ctr, San Francisco Bay Estuary Field Stn, Vallejo, CA 94592 USA. [Takekawa, John Y.] Natl Audubon Soc, Div Sci, 220 Montgomery St, San Francisco, CA 94104 USA. RP Rosencranz, JA (reprint author), Univ Calif Los Angeles, Inst Environm & Sustainabil, Los Angeles, CA 90095 USA.; Rosencranz, JA (reprint author), US Geol Survey, Western Ecol Res Ctr, San Francisco Bay Estuary Field Stn, Vallejo, CA 94592 USA. EM jrosencranz@usgs.gov OI Ambrose, Richard/0000-0001-8653-6487; Ganju, Neil/0000-0002-1096-0465 FU Region 8 US Fish & Wildlife Service Inventory and Monitoring Program; Southwest Climate Science Center; US Geological Survey (USGS) Western Ecological Research Center; USGS Coastal and Marine Geology Program; USGS Climate and Land Use Research and Development Program FX The authors thank Tristan Edgarian, Chase Freeman, Arianna Goodman, Jimmie Lambert, Katharine Lovett, Katherine Powelson, and Yareli Sanchez for their technical expertise and field assistance. We would like to thank Region 8 US Fish & Wildlife Service Inventory and Monitoring Program, the Southwest Climate Science Center, US Geological Survey (USGS) Western Ecological Research Center, USGS Coastal and Marine Geology Program, and USGS Climate and Land Use Research and Development Program for funding support. The authors would like to thank Andy Yuen and Kirk Gilligan, representing Seal Beach National Wildlife Refuge, Region 8 US Fish & Wildlife Service Refuges for access and field support. We also would like to thank Martin Ruane from Naval Base Ventura County Point Mugu for access and permission to conduct study. NR 52 TC 2 Z9 2 U1 5 U2 12 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1559-2723 EI 1559-2731 J9 ESTUAR COAST JI Estuaries Coasts PD JUL PY 2016 VL 39 IS 4 BP 1035 EP 1049 DI 10.1007/s12237-015-0056-y PG 15 WC Environmental Sciences; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA DO5BM UT WOS:000377798600011 ER PT J AU Rosencranz, JA Ganju, NK Ambrose, RF Brosnahan, SM Dickhudt, PJ Guntenspergen, GR MacDonald, GM Takekawa, JY Thorne, KM AF Rosencranz, Jordan A. Ganju, Neil K. Ambrose, Richard F. Brosnahan, Sandra M. Dickhudt, Patrick J. Guntenspergen, Glenn R. MacDonald, Glen M. Takekawa, John Y. Thorne, Karen M. TI Balanced Sediment Fluxes in Southern California's Mediterranean-Climate Zone Salt Marshes (vol 39, pg 1035, 2016) SO ESTUARIES AND COASTS LA English DT Correction C1 [Rosencranz, Jordan A.; Ambrose, Richard F.; MacDonald, Glen M.] Univ Calif Los Angeles, Inst Environm & Sustainabil, Los Angeles, CA 90095 USA. [Ganju, Neil K.; Brosnahan, Sandra M.] US Geol Survey, Woods Hole Coastal & Marine Sci Ctr, Woods Hole, MA 02556 USA. [Ambrose, Richard F.] Univ Calif Los Angeles, Dept Environm Hlth Sci, Los Angeles, CA 90095 USA. [Dickhudt, Patrick J.] US Army, Corps Engineers, Field Res Facil, Kitty Hawk, NC 27949 USA. [Guntenspergen, Glenn R.] US Geol Survey, Patuxent Wildlife Res Ctr, Superior, WI 54880 USA. [MacDonald, Glen M.] Univ Calif Los Angeles, Dept Geog, Los Angeles, CA 90095 USA. [Rosencranz, Jordan A.; Takekawa, John Y.; Thorne, Karen M.] US Geol Survey, Western Ecol Res Ctr, San Francisco Bay Estuary Field Stn, Vallejo, CA 94592 USA. [Takekawa, John Y.] Natl Audubon Soc, Div Sci, 220 Montgomery St, San Francisco, CA 94104 USA. RP Rosencranz, JA (reprint author), Univ Calif Los Angeles, Inst Environm & Sustainabil, Los Angeles, CA 90095 USA.; Rosencranz, JA (reprint author), US Geol Survey, Western Ecol Res Ctr, San Francisco Bay Estuary Field Stn, Vallejo, CA 94592 USA. EM jrosencranz@usgs.gov NR 1 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1559-2723 EI 1559-2731 J9 ESTUAR COAST JI Estuaries Coasts PD JUL PY 2016 VL 39 IS 4 BP 1296 EP 1297 DI 10.1007/s12237-016-0077-1 PG 2 WC Environmental Sciences; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA DO5BM UT WOS:000377798600032 ER PT J AU Clark, ME Will, MD AF Clark, Mary E. Will, Micah D. TI Intestinal-Type Adenocarcinoma Arising in a Mature Cystic Teratoma of the Ovary SO INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY LA English DT Article DE Ovarian carcinoma; Ovarian mucinous carcinoma; Intestinal-type adenocarcinoma; Mature cystic teratoma; Germ cell tumor; Dermoid cyst ID SQUAMOUS-CELL CARCINOMA; GASTROINTESTINAL EPITHELIUM; MUCINOUS ADENOCARCINOMA AB Here, we present a rare case of intestinal type adenocarcinoma arising in mature cystic teratoma (MCT) and review all previously reported similar cases with emphasis on the immunohistochemical characteristics of prior cases. Nine prior cases of intestinal type adenocarcinoma arising in MCT have been previously reported. Two of the prior cases as well as this case have been associated with CA19-9 elevation. CK20 is consistently strongly positive and CK7 is usually negative in cases of intestinal type adenocarcinoma arising in MCT. This contrasts with mucinous tumors of the ovary which are known to be usually CK7 strongly positive and inconsistently CK20 positive. The pattern of strong CK20 staining and often negative or weak CK7 staining is common to mucinous neoplasms arising in MCT. These findings suggest that the less common subset of primary mucinous ovarian tumors that have strong CK20 staining and partial or negative CK7 staining may represent a group of tumors with germ cell origin rather than the more common surface epithelial origin. C1 [Clark, Mary E.; Will, Micah D.] Brooke Army Med Ctr, Dept Pathol & Area Lab Serv, San Antonio Uniformed Serv Hlth Educ Consortium, 3551 Roger Brooke Dr 3600 Fl 4, San Antonio, TX 78234 USA. RP Clark, ME (reprint author), Brooke Army Med Ctr, Dept Pathol & Area Lab Serv, San Antonio Uniformed Serv Hlth Educ Consortium, 3551 Roger Brooke Dr 3600 Fl 4, San Antonio, TX 78234 USA. EM mary.e.clark187.mil@mail.mil NR 15 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0277-1691 EI 1538-7151 J9 INT J GYNECOL PATHOL JI Int. J. Gynecol. Pathol. PD JUL PY 2016 VL 35 IS 4 BP 352 EP 356 DI 10.1097/PGP.0000000000000258 PG 5 WC Obstetrics & Gynecology; Pathology SC Obstetrics & Gynecology; Pathology GA DO2ON UT WOS:000377619500010 PM 26937866 ER PT J AU Cnops, L van Griensven, J Honko, AN Bausch, DG Sprecher, A Hill, CE Colebunders, R Johnson, JC Griffiths, A Palacios, GF Kraft, CS Kobinger, G Hewlett, A Norwood, DA Sabeti, P Jahrling, PB Formenty, P Kuhn, JH Arien, KK AF Cnops, Lieselotte van Griensven, Johan Honko, Anna N. Bausch, Daniel G. Sprecher, Armand Hill, Charles E. Colebunders, Robert Johnson, Joshua C. Griffiths, Anthony Palacios, Gustavo F. Kraft, Colleen S. Kobinger, Gary Hewlett, Angela Norwood, David A. Sabeti, Pardis Jahrling, Peter B. Formenty, Pierre Kuhn, Jens H. Arien, Kevin K. TI Essentials of filoviral load quantification SO LANCET INFECTIOUS DISEASES LA English DT Article ID EBOLA-VIRUS DISEASE; REVERSE TRANSCRIPTION-PCR; POINT-OF-CARE; VIRAL LOAD; INFECTIOUS-DISEASES; HEMORRHAGIC-FEVER; MARBURG VIRUS; SIERRA-LEONE; INTERNATIONAL STANDARD; SEXUAL TRANSMISSION AB Quantitative measurement of viral load is an important parameter in the management of filovirus disease outbreaks because viral load correlates with severity of disease, survival, and infectivity. During the ongoing Ebola virus disease outbreak in parts of Western Africa, most assays used in the detection of Ebola virus disease by more than 44 diagnostic laboratories yielded qualitative results. Regulatory hurdles involved in validating quantitative assays and the urgent need for a rapid Ebola virus disease diagnosis precluded development of validated quantitative assays during the outbreak. Because of sparse quantitative data obtained from these outbreaks, opportunities for study of correlations between patient outcome, changes in viral load during the course of an outbreak, disease course in asymptomatic individuals, and the potential for virus transmission between infected patients and contacts have been limited. We strongly urge the continued development of quantitative viral load assays to carefully evaluate these parameters in future outbreaks of filovirus disease. C1 [Cnops, Lieselotte; van Griensven, Johan] Inst Trop Med, Dept Clin Sci, B-2000 Antwerp, Belgium. [Honko, Anna N.; Johnson, Joshua C.; Kuhn, Jens H.] NIAID, Integrated Res Facil Ft Detrick, Div Clin Res, NIH, Frederick, MD USA. [Bausch, Daniel G.; Formenty, Pierre] WHO, CH-1211 Geneva, Switzerland. [Sprecher, Armand] Medecins Sans Frontieres Operat Ctr Brussels, Brussels, Belgium. [Hill, Charles E.] Emory Univ Hosp, Mol Diagnost Lab, 1364 Clifton Rd NE, Atlanta, GA 30322 USA. [Colebunders, Robert] Univ Antwerp, Fac Med & Hlth Sci, Global Hlth Inst, Int Hlth Unit, B-2020 Antwerp, Belgium. [Griffiths, Anthony] Texas Biomed Res Inst, Dept Virol & Immunol, San Antonio, TX USA. [Palacios, Gustavo F.; Norwood, David A.] US Army, Med Res Inst Infect Dis, Frederick, MD USA. [Kraft, Colleen S.] Emory Univ, Sch Med, Pathol & Lab Med, Atlanta, GA USA. [Kobinger, Gary] Univ Manitoba, Publ Hlth Agcy Canada, Natl Microbiol Lab, Winnipeg, MB, Canada. [Hewlett, Angela] Univ Nebraska Med Ctr, Omaha, NE USA. [Sabeti, Pardis] Harvard Univ, Dept Organism & Evolutionary Biol, FAS Ctr Syst Biol, Cambridge, MA 02138 USA. [Arien, Kevin K.] Inst Trop Med, Dept Biomed Sci, B-2000 Antwerp, Belgium. RP Arien, KK (reprint author), Inst Trop Med, Dept Biomed Sci, B-2000 Antwerp, Belgium. EM karien@itg.be RI Palacios, Gustavo/I-7773-2015; OI Palacios, Gustavo/0000-0001-5062-1938; Honko, Anna/0000-0001-9165-148X FU Battelle Memorial Institute; US National Institute of Allergy and Infectious Diseases (NIAID) [HHSN272200700016I]; European Union's Horizon research and innovation programme [666094] FX We thank Laura Bollinger (Battelle Memorial Institute, USA) for editing this paper. The content of this publication does not necessarily reflect the views or policies of the US Department of Health and Human Services, the US Department of Defense, the US Department of the Army, WHO, or the institutions and companies affiliated with the authors. This work was funded in part through Battelle Memorial Institute's prime contract with the US National Institute of Allergy and Infectious Diseases (NIAID) under Contract No. HHSN272200700016I. JCJ is an employee of Battelle Memorial Institute. A subcontractor to Battelle Memorial Institute who performed this work is: JHK, an employee of Tunnell Government Services Inc. LC holds an innovation mandate from the Agency for Innovation by Science and Technology (IWT) from the Flemish Government. JVG is supported by the European Union's Horizon 2020 research and innovation programme (grant agreement number 666094). NR 56 TC 2 Z9 2 U1 1 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1473-3099 EI 1474-4457 J9 LANCET INFECT DIS JI Lancet Infect. Dis. PD JUL PY 2016 VL 16 IS 7 BP E134 EP E138 DI 10.1016/S1473-3099(16)30063-9 PG 5 WC Infectious Diseases SC Infectious Diseases GA DP2LH UT WOS:000378319600004 PM 27296694 ER PT J AU Dunn, JC Fares, A Kusnezov, N Chandler, P Cordova, C Orr, J Belmont, P Pallis, M AF Dunn, John C. Fares, Austin Kusnezov, Nicholas Chandler, Philip Cordova, Christopher Orr, Justin Belmont, Philip Pallis, Mark TI US service member tourniquet use on the battlefield: Iraq and Afghanistan 2003-2011 SO TRAUMA-ENGLAND LA English DT Article DE Tourniquet; hemorrhage control; military; cavalry scout; trauma ID COMBAT WOUNDS; ARMY; FREEDOM AB Introduction Tourniquet use has not been studied regarding specifically combat-intense military occupational specificities. This analysis examined the survivability, frequency of use, and nature of injuries in which tourniquets were employed among personnel in a single combat-specific military occupational specialty during combat operations. Methods Injuries sustained by the combat-specific soldier, the cavalry scout, from 2003 to 2011 were identified using the Joint Theater Trauma Registry. Basic demographic information, mechanism of injury, injury characteristics, and mortality were recorded. Results Of the 453 cavalry scouts wounded in action, 313 had adequate documentation upon arrival to a field hospital. Tourniquets were applied to 24 (7.7%) extremity wounds, 23 (96%) of these soldiers survived and one died of wounds (4.2%). Among those is in which tourniquets were used, there were seven (30%) senior enlisted and 16 (70%) junior enlisted soldiers with an average age of 24.8 years. Injuries were caused by gunshot wounds in 4 (17%), explosions in 18 (74%) and other mechanisms in two (8.3%). The primary reason for tourniquet application was open fracture (n=14, 61%), followed by vascular injury (n=5, 22%), and amputation (n=3, 13%). Other penetrating injuries were present in 19 (83%) of scouts. Conclusion The high survivability of patients transported with tourniquet in place underscores the importance of battlefield tourniquet application. Continued focus on education and equipping combat personnel with tourniquets is critical to survivability of the injured solider. C1 [Dunn, John C.; Kusnezov, Nicholas; Chandler, Philip; Cordova, Christopher; Orr, Justin; Pallis, Mark] William Beaumont Army Med Ctr, Ft Bliss, TX USA. [Fares, Austin] Creighton Univ, Sch Med, 3561 Howard St, Omaha, NE 68105 USA. [Belmont, Philip] Anderson Orthopaed Clin, Alexandria, VA USA. RP Fares, A (reprint author), Creighton Univ, Sch Med, 3561 Howard St, Omaha, NE 68105 USA. EM austinfares@creighton.edu NR 21 TC 0 Z9 0 U1 2 U2 2 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1460-4086 EI 1477-0350 J9 TRAUMA JI Trauma PD JUL PY 2016 VL 18 IS 3 BP 216 EP 220 DI 10.1177/1460408616632026 PG 5 WC Emergency Medicine SC Emergency Medicine GA DO5MH UT WOS:000377826700007 ER PT J AU Zander, NE Piehler, T Banton, R Boggs, M AF Zander, Nicole E. Piehler, Thuvan Banton, Rohan Boggs, Mary TI The effect of explosive blast loading on human neuroblastoma cells SO ANALYTICAL BIOCHEMISTRY LA English DT Article DE Traumatic brain injury; Explosive blast; In vitro model; Neurons; Membrane damage; Oxidative stress ID TRAUMATIC BRAIN-INJURY; IN-VITRO; CULTURES; DAMAGE; MODEL AB Diagnosis of mild to moderate traumatic brain injury is challenging because brain tissue damage progresses slowly and is not readily detectable by conventional imaging techniques. We have developed a novel in vitro model to study primary blast loading on dissociated neurons using nitroamine explosives such as those used on the battlefield. Human neuroblastoma cells were exposed to single and triple 50 psi explosive blasts and single 100-psi blasts. Changes in membrane permeability and oxidative stress showed a significant increase for the single and triple 100-psi blast conditions compared with single 50 psi blast and controls. Published by Elsevier Inc. C1 [Zander, Nicole E.; Piehler, Thuvan; Banton, Rohan] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Boggs, Mary] Univ Delaware, Dept Biol, Newark, DE 19716 USA. RP Zander, NE (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM nicole.e.zander.civ@mail.mil FU U.S. Army Research Laboratory's Director's Science Initiative [DSI-13-WMR-2D-005] FX This research was supported by the U.S. Army Research Laboratory's Director's Science Initiative (DSI-13-WMR-2D-005). NR 11 TC 2 Z9 2 U1 3 U2 4 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0003-2697 EI 1096-0309 J9 ANAL BIOCHEM JI Anal. Biochem. PD JUL 1 PY 2016 VL 504 BP 4 EP 6 DI 10.1016/j.ab.2016.03.009 PG 3 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA DN4RN UT WOS:000377055000002 PM 27033003 ER PT J AU Kocifaj, M Kundracik, F Videen, G Yuffa, AJ Klacka, J AF Kocifaj, Miroslav Kundracik, Frantisek Videen, Gorden Yuffa, Alex J. Klacka, Jozef TI Optical resonances in electrically charged particles and their relation to the Drude model SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article; Proceedings Paper CT 15th Conference on Electromagnetic and Light Scattering (ELS) CY JUN 21-26, 2015 CL Leipzig, GERMANY DE Electromagnetic scattering; Charged particles; Drude model ID ELECTROMAGNETIC-WAVES; SCATTERING; NANOPARTICLES; ABSORPTION; SPHERES; LIGHT AB The Drude model is conventionally used to explain the average motion of electrons in typical material. In this paper, we analyze the individual terms of the Drude model in order to uncover their influence on the scattering properties of small particles. Namely, a query on whether resonance enhancement is due to optical effects or the conductivity model. This query arose from our earlier theoretical and numerical experiments and still remains unresolved today. We show that certain resonance features are caused primarily by the interaction of the electromagnetic wave with the excess electric charge on the particles. Furthermore, we show that the role of a conductivity model is limited to only establishing the relative importance of the inertial moment of the carriers and the viscous drag forces. For frequencies omega <= k(B)T/h, the viscous forces only cause minor damping effects and the change in the peak resonance (along with its amplitude) are caused by the electric and inertial forces. These forces dominate because the viscous forces quickly decay with decreasing temperature. In order to demonstrate the optical behavior of charged water droplets, we construct a Mie-series solution with modified boundary conditions that properly account for the excess electric charge on the droplets. Our solution explains the weak scattering enhancement for frequencies far beyond the resonance, and it also predicts an absorption resonance edge in the long-wavelength limit. Our findings are not only useful to theoreticians who focus on the individual parameters such as the viscous term in the Drude model and/or search for better surface conductivity models, but also to experimentalists who gather as much data as possible in order to ascertain how the numerically determined optical properties compare with the experimental measurements. (C) 2015 Elsevier Ltd. All rights reserved. C1 [Kocifaj, Miroslav] Slovak Acad Sci, ICA, Dubravska Rd 9, Bratislava 84503, Slovakia. [Kocifaj, Miroslav; Kundracik, Frantisek; Klacka, Jozef] Comenius Univ, Fac Math Phys & Informat, Dept Expt Phys, Bratislava 84248, Slovakia. [Videen, Gorden; Yuffa, Alex J.] Army Res Lab, Adelphi, MD 20783 USA. RP Kocifaj, M (reprint author), Slovak Acad Sci, ICA, Dubravska Rd 9, Bratislava 84503, Slovakia.; Kocifaj, M (reprint author), Comenius Univ, Fac Math Phys & Informat, Dept Expt Phys, Bratislava 84248, Slovakia. EM kocifaj@savba.sk RI Yuffa, Alex/B-5498-2014 OI Yuffa, Alex/0000-0002-3600-1131 NR 22 TC 1 Z9 1 U1 9 U2 18 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 EI 1879-1352 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD JUL PY 2016 VL 178 SI SI BP 224 EP 229 DI 10.1016/j.jqsrt.2015.11.021 PG 6 WC Optics; Spectroscopy SC Optics; Spectroscopy GA DM9SL UT WOS:000376705900021 ER PT J AU Mishchenko, MI Zakharova, NT Khlebtsov, NG Videen, G Wriedt, T AF Mishchenko, Michael I. Zakharova, Nadezhda T. Khlebtsov, Nikolai G. Videen, Gorden Wriedt, Thomas TI Comprehensive thematic T-matrix reference database: A 2014-2015 update SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article; Proceedings Paper CT 15th Conference on Electromagnetic and Light Scattering (ELS) CY JUN 21-26, 2015 CL Leipzig, GERMANY DE Electromagnetic scattering; T-matrix method; Maxwell's equations; Complex scattering objects ID DISCRETE-DIPOLE APPROXIMATION; RAINDROP SIZE DISTRIBUTION; EQUIVALENT COATED SPHERES; MIDLATITUDE CIRRUS CLOUDS; BOUNDARY-CONDITION METHOD; BAND POLARIMETRIC RADAR; DUAL-POLARIZATION RADAR; AXIS GAUSSIAN-BEAM; OPTICAL-PROPERTIES; LIGHT-SCATTERING AB The T-matrix method is one of the most versatile and efficient direct computer solvers of the macroscopic Maxwell equations and is widely used for the computation of electromagnetic scattering by single and composite particles, discrete random media, and particles in the vicinity of an interface separating two half-spaces with different refractive indices. This paper is the seventh update to the comprehensive thematic database of peer reviewed T-matrix publications initiated by us in 2004 and includes relevant publications that have appeared since 2013. It also lists a number of earlier publications overlooked previously. Published by Elsevier Ltd. C1 [Mishchenko, Michael I.] NASA, Goddard Inst Space Studies, 2880 Broadway, New York, NY 10025 USA. [Zakharova, Nadezhda T.] Trinnovim LLC, 2880 Broadway, New York, NY 10025 USA. [Khlebtsov, Nikolai G.] Russian Acad Sci, Inst Biochem & Physiol Plants & Microorganisms, 13 Entuziastov Ave, Saratov 410015, Russia. [Videen, Gorden] US Army, Res Lab, AMSRL IS EE, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Wriedt, Thomas] Inst Werkstofftech, Badgasteiner Str 3, D-28359 Bremen, Germany. RP Mishchenko, MI (reprint author), NASA, Goddard Inst Space Studies, 2880 Broadway, New York, NY 10025 USA. EM michael.i.mishchenko@nasa.gov RI Khlebtsov, Nikolai/D-6199-2017 NR 217 TC 4 Z9 4 U1 9 U2 20 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 EI 1879-1352 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD JUL PY 2016 VL 178 SI SI BP 276 EP 283 DI 10.1016/j.jqsrt.2015.11.005 PG 8 WC Optics; Spectroscopy SC Optics; Spectroscopy GA DM9SL UT WOS:000376705900027 ER PT J AU McDonald, J Satapathy, S AF McDonald, Jason Satapathy, Sikhanda TI Surface waves and their influence on cone cracking in brittle materials SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Ceramics; Cracking; Dynamic loading; Surface waves; Laplace transform method ID IMPLEMENTATION; TRANSFORM; IMPACT AB Prior experimental studies have shown substantial improvement in the ballistic performance of ceramics due to surface treatment with thin coatings; however, no correlation with material properties and bonding conditions has been found and no mechanism has yet been definitively established. It is expected that the high strain rates present in a ballistic event will produce surface waves and it is plausible that the interaction of these waves with surface flaws may contribute significantly to initial crack growth and the onset of failure in brittle materials. In the present work a Laplace-transform-based computational framework is implemented. This technique can be considered complementary to other computational schemes such as finite element and finite difference techniques for the study of elastic waves in solids. Extension of this framework to multi-layer systems is possible and may provide insight into whether or not the observed surface-treatment effect in ceramics can be attributed to wave modification. Published by Elsevier Ltd. C1 [McDonald, Jason; Satapathy, Sikhanda] US Army Res Lab, RDRL WMP B, Aberdeen Proving Ground, MD 21005 USA. RP McDonald, J (reprint author), US Army Res Lab, RDRL WMP B, Aberdeen Proving Ground, MD 21005 USA. EM jason.r.mcdonald27.civ@mail.mil FU US Army Research Laboratory [W911QX-14-C-0016] FX The research reported in this document was performed in connection with contract/instrument W911QX-14-C-0016 with the US Army Research Laboratory. The views and conclusions contained in this document are those of TKC Global and the US Army Research Laboratory. Citation of manufacturer's or trade names does not constitute an official endorsement or approval of the use thereof. The US government is authorized to reproduce and distribute reprints for government purposes notwithstanding any copyright notation hereon. NR 31 TC 0 Z9 0 U1 4 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X EI 1879-3509 J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD JUL PY 2016 VL 93 BP 144 EP 152 DI 10.1016/j.ijimpeng.2016.03.003 PG 9 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA DM7OV UT WOS:000376550800013 ER PT J AU Cho, JH Chen, IR Chan, KS AF Cho, Jin-Hee Chen, Ing-Ray Chan, Kevin S. TI Trust threshold based public key management in mobile ad hoc networks SO AD HOC NETWORKS LA English DT Article DE Public key management; Mobile ad hoc networks; Trust; Private key; Public key; Certificate authority ID CRYPTOGRAPHY; RELIABILITY AB Public key management in mobile ad hoc networks (MANETs) has been studied for several decades. However, the unique characteristics of MANETs have imposed great challenges in designing a fully distributed public key management protocol under resource constrained MANET environments. These challenges include no centralized trusted entities, resource constraints, and high security vulnerabilities. This work proposes a fully distributed trust-based public key management approach for MANETs using a soft security mechanism based on the concept of trust. Instead of using hard security approaches, as in traditional security techniques, to eliminate security vulnerabilities, our work aims to maximize performance by relaxing security requirements based on the perceived trust. We propose a composite trust-based public key management (CTPKM) with the goal of maximizing performance while mitigating security vulnerability. Each node employs a trust threshold to determine whether or not to trust another node. Our simulation results show that an optimal trust threshold exists to best balance and meet the conflicting goals between performance and security, by exploiting the inherent tradeoff between trust and risk. The results also show that CTPKM minimizes risk (i.e., information leakout) using an optimal trust threshold while maximizing service availability with acceptable communication overhead incurred by trust and key management operations. We demonstrate that CTPKM outperforms both existing non-trust-based and trust-based counterparts. Published by Elsevier B.V. C1 [Cho, Jin-Hee; Chan, Kevin S.] US Army, Res Lab, Adelphi, MD 20783 USA. [Chen, Ing-Ray] Virginia Tech, Dept Comp Sci, Falls Church, VA 22043 USA. RP Cho, JH (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA. EM jinhee.cho@us.army.mil; irchen@vt.edu; kevin.s.chan@us.army.mil FU U.S. Army Research Laboratory; U.S. Army Research Office [W911NF-12-1-0445]; Department of Defense (DoD) through the office of the Assistant Secretary of Defense for Research and Engineering (ASD (RE)) FX This work is supported in part by the U.S. Army Research Laboratory and the U.S. Army Research Office under contract no. W911NF-12-1-0445. This research was also partially supported by the Department of Defense (DoD) through the office of the Assistant Secretary of Defense for Research and Engineering (ASD (R&E)). The views and opinions of the author(s) do not reflect those of the DoD or ASD (R&E). NR 46 TC 0 Z9 0 U1 6 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1570-8705 EI 1570-8713 J9 AD HOC NETW JI Ad Hoc Netw. PD JUL 1 PY 2016 VL 44 BP 58 EP 75 DI 10.1016/j.adhoc.2016.02.014 PG 18 WC Computer Science, Information Systems; Telecommunications SC Computer Science; Telecommunications GA DL3CI UT WOS:000375511400005 ER PT J AU Shkuratov, Y Kaydash, V Rohacheva, L Korokhin, V Ivanov, M Velikodsky, Y Videen, G AF Shkuratov, Y. Kaydash, V. Rohacheva, L. Korokhin, V. Ivanov, M. Velikodsky, Y. Videen, G. TI Comparison of lunar red spots including the crater copernicus SO ICARUS LA English DT Article DE Moon, Surface; Photometry; Spectrophotometry ID MAIRAN DOMES; MOON; GRUITHUISEN; VOLCANISM; ABUNDANCE; IMPACT; WATER; IRON; CLEMENTINE; RESOLUTION AB The lunar red spots, Helmet, Hansteen Alpha, and the NW quadrant of the crater Copernicus, were selected for a complex comparative investigation of their characteristics measured by the spacecraft Clementine, LRO, and Chandrayaan-1. For the analysis we used the following parameters: the reflectance A(750 nm), color-ratio A(750 nm)/A(415 nm), parameter of optical micro-roughness (LRO WAC), parameters deduced from LRO Diviner data, optical maturity OMAT, abundance of FeO and TiO2 (Clementine UVVIS and LRO WAC data), oxygen content determined using Lunar Prospector data, and parameters characterizing the 0.95-mu m and 2.2-mu m bands of Fe2+ ions (crystal field bands), and 2.8-mu m band of H2O/OH and/or Fe2+ ions. The red spots Helmet and Hansteen Alpha are considered to be extrusions of rhyolite composition, which can be attributed to the Nectarian period; we did not find contradictions of this assumption. As for the Copernicus red spot, this, perhaps, is a similar formation that has been destroyed by the impact. We demonstrate that the material of the Copernicus red spot probably has the same composition as the classical red spots Helmet and Hansteen Alpha. The distributions of the parameter of optical micro-roughness and optical maturity OMAT show that the Copernicus red anomaly was not formed during the long evolution of the lunar surface, but results from crater formation. We find several confirmations of the hypothesis that the Copernicus red spot can be a residual of a red material (possibly rhyolite) extrusion that was involved in the impact process. The red material could have been partially melted, crushed, and ejected to the crater's north-western vicinity. The described red asymmetry of the Copernicus ejecta can be related to the eccentricity, relative to the extrusion, of the impact and/or to the inclination of the impactor trajectory. The latter also is confirmed by an analysis of the region, which is based on the geological map shown in this paper. (C) 2016 Elsevier Inc. All rights reserved. C1 [Shkuratov, Y.; Kaydash, V.; Rohacheva, L.; Korokhin, V.; Velikodsky, Y.] Kharkiv VN Karazin Natl Univ, Inst Astron, 35 Sumskaya St, UA-61022 Kharkov, Ukraine. [Ivanov, M.] Russian Acad Sci, VI Vernadsky Inst Geochem & Analyt Chem, 19 Kosygin Str, Moscow 119991, Russia. [Ivanov, M.] Moscow State Univ Geodesy & Cartog MiiGAIK, Gorokhovsky 4, Moscow 105064, Russia. [Velikodsky, Y.] Natl Aviat Univ, Cosmonaut Komarov Ave 1, UA-03680 Kiev, Ukraine. [Videen, G.] Space Sci Inst, 4750 Walnut St,Suite 205, Boulder, CO 80301 USA. [Videen, G.] Army Res Lab AMSRL CI EM, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Shkuratov, Y (reprint author), Kharkiv VN Karazin Natl Univ, Inst Astron, 35 Sumskaya St, UA-61022 Kharkov, Ukraine. EM yuriy.shkuratov@gmail.com OI Velikodsky, Yuri/0000-0002-8219-128X; Rohachova, Larysa/0000-0002-8830-2390 NR 50 TC 1 Z9 1 U1 1 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0019-1035 EI 1090-2643 J9 ICARUS JI Icarus PD JUL 1 PY 2016 VL 272 BP 125 EP 139 DI 10.1016/j.icarus.2016.02.034 PG 15 WC Astronomy & Astrophysics SC Astronomy & Astrophysics GA DK0QK UT WOS:000374617100011 ER PT J AU Drnec, K Marathe, AR Lukos, JR Metcalfe, JS AF Drnec, Kim Marathe, Amar R. Lukos, Jamie R. Metcalfe, Jason S. TI From Trust in Automation to Decision Neuroscience: Applying Cognitive Neuroscience Methods to Understand and Improve Interaction Decisions Involved in Human Automation Interaction SO FRONTIERS IN HUMAN NEUROSCIENCE LA English DT Review DE trust in automation; interaction decisions; decision making; human automation interaction; neuroergonomics ID VENTROMEDIAL PREFRONTAL CORTEX; HUMAN BRAIN; OSCILLATORY ACTIVITY; HUMAN INTERVENTION; VISUAL FIXATIONS; SELF-CONFIDENCE; PARIETAL CORTEX; NEURAL SYSTEMS; FRONTAL-CORTEX; FALSE ALARMS AB Human automation interaction (HAI) systems have thus far failed to live up to expectations mainly because human users do not always interact with the automation appropriately. Trust in automation (TiA) has been considered a central influence on the way a human user interacts with an automation; if TiA is too high there will be overuse, if TiA is too low there will be disuse. However, even though extensive research into TiA has identified specific HAI behaviors, or trust outcomes, a unique mapping between trust states and trust outcomes has yet to be clearly identified. Interaction behaviors have been intensely studied in the domain of HAI and TiA and this has led to a reframing of the issues of problems with HAI in terms of reliance and compliance. We find the behaviorally defined terms reliance and compliance to be useful in their functionality for application in real world situations. However, we note that once an inappropriate interaction behavior has occurred it is too late to mitigate it. We therefore take a step back and look at the interaction decision that precedes the behavior. We note that the decision neuroscience community has revealed that decisions are fairly stereotyped processes accompanied by measurable psychophysiological correlates. Two literatures were therefore reviewed. TiA literature was extensively reviewed in order to understand the relationship between TiA and trust outcomes, as well as to identify gaps in current knowledge. We note that an interaction decision precedes an interaction behavior and believe that we can leverage knowledge of the psychophysiological correlates of decisions to improve joint system performance. As we believe that understanding the interaction decision will be critical to the eventual mitigation of inappropriate interaction behavior, we reviewed the decision making literature and provide a synopsis of the state of the art understanding of the decision process from a decision neuroscience perspective. We forward hypotheses based on this understanding that could shape a research path toward the ability to mitigate interaction behavior in the real world. C1 [Drnec, Kim; Marathe, Amar R.; Metcalfe, Jason S.] US Army, Human Res & Engn Directorate, Res Lab, Aberdeen, MD USA. [Lukos, Jamie R.] Space & Naval Warfare Syst Ctr Pacific, Adv Concepts & Appl Res Branch, San Diego, CA USA. RP Drnec, K (reprint author), US Army, Human Res & Engn Directorate, Res Lab, Aberdeen, MD USA. EM kdrnec@gmail.com FU U.S. Office of the Secretary of Defense through the Autonomy Research Pilot Initiative [MIPR DWAM31168] FX This research was supported by the U.S. Office of the Secretary of Defense through the Autonomy Research Pilot Initiative (MIPR DWAM31168) as well as by an appointment to the US Army Research Laboratoiy Postdoctoral Fellowship program administered by the Oak Ridge Associated Universities through a cooperative agreement with the US Army Research Laboratory. We would also like to acknowledge Dr. Kristin Schaefer for her insights and guidance regarding understanding the complex set of human factors that influence-trust: in automation. The authors are also very grateful for the feedback and guidance of two reviewers whose suggestions have proven rather valuable in improving the quality of the final work. NR 115 TC 0 Z9 0 U1 5 U2 10 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1662-5161 J9 FRONT HUM NEUROSCI JI Front. Hum. Neurosci. PD JUN 30 PY 2016 VL 10 AR 290 DI 10.3389/fnhum.2016.00290 PG 14 WC Neurosciences; Psychology SC Neurosciences & Neurology; Psychology GA DQ2AT UT WOS:000379003600001 PM 27445741 ER PT J AU Hannaman, D Dupuy, LC Ellefsen, B Schmaljohn, CS AF Hannaman, Drew Dupuy, Lesley C. Ellefsen, Barry Schmaljohn, Connie S. TI A Phase 1 clinical trial of a DNA vaccine for Venezuelan equine encephalitis delivered by intramuscular or intradermal electroporation SO VACCINE LA English DT Article DE Venezuelan equine encephalitis; DNA vaccine; Electroporation; Intramuscular; Intradermal; Human; Clinical trial; Phase 1 ID NEUTRALIZING ANTIBODIES; VIRUS; STRAIN; MICE AB Venezuelan equine encephalitis virus (VEEV), a mosquito-borne alphavirus, causes periodic epizootics in equines and is a recognized biological defense threat for humans. There are currently no FDA-licensed vaccines against VEEV. We developed a candidate DNA vaccine expressing the E3-E2-6K-E1 genes of VEEV (pWRG/VEE) and performed a Phase 1 clinical study to assess the vaccine's safety, reactogenicity, tolerability, and immunogenicity when administered by intramuscular (IM) or intradermal (ID) electroporation (EP) using the Ichor Medical Systems TriGrid (TM) Delivery System. Subjects in IM-EP groups received 0.5 mg (N = 8) or 2.0 mg (N = 9) of pWRG/VEE or a saline placebo (N=4) in a 1.0ml injection. Subjects in ID-EP groups received 0.08 mg (N= 8) or 0.3 mg (N=8) of DNA or a saline placebo (N = 4) in a 0.15 ml injection. Subjects were monitored for a total period of 360 days. No vaccine- or device-related serious adverse events were reported. Based on the results of a subject questionnaire, the IM- and ID-EP procedures were both considered to be generally acceptable for prophylactic vaccine administration, with the acute tolerability of ID EP delivery judged to be greater than that of IM-EP delivery. All subjects (100%) in the high and low dose IM-EP groups developed detectable VEEV-neutralizing antibodies after two or three administrations of pWRG/VEE, respectively. VEEV-neutralizing antibody responses were detected in seven of eight subjects (87.5%) in the high dose and five of eight subjects (62.5%) in the low dose ID-EP groups after three vaccine administrations. There was a correlation between the DNA dose and the magnitude of the resulting VEEV-neutralizing antibody responses for both IM and ID EP delivery. These results indicate that pWRG/VEE delivered by either IM- or ID-EP is safe, tolerable, and immunogenic in humans at the evaluated dose levels. Published by Elsevier Ltd. C1 [Hannaman, Drew; Ellefsen, Barry] Ichor Med Syst Inc, San Diego, CA USA. [Dupuy, Lesley C.; Schmaljohn, Connie S.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Schmaljohn, CS (reprint author), US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM connie.s.schmaljohn.civ@mail.mil FU Joint Science and Technology Office for Chemical and Biological Defense of the Defense Threat and Reduction Agency [HDTRA1-07-C-0029]; U.S. Army Medical Research and Material Command Cooperative Research and Development [W81XWH-07-0029] FX The investigators wish to thank all of the study volunteers for their participation and willingness to contribute to this VEEV DNA vaccine development effort. We are also grateful to the staff of Accelovance for the conduct of the study. We gratefully acknowledge Ichor staff who contributed to this work, especially Jake Doucet, Robert Dees, Claire Evans, Karen Dolter, Lacey Tichenor, Juwan Song, and Robert Bernard. We also acknowledge and thank Nicole VanDeusen and Carolyn Six for their excellent technical assistance in performing the PRNT assays. We also thank the USAMRII D and USAMMDA personnel who provided regulatory advice and technical assistance with potency and stability studies to include Rhonda DaSilva, Michelle Richards, Catherine Badger and Ryan Adams. The studies described herein were supported by Contract HDTRA1-07-C-0029 to Ichor Medical Systems from the Joint Science and Technology Office for Chemical and Biological Defense of the Defense Threat and Reduction Agency. This research was performed under U.S. Army Medical Research and Material Command Cooperative Research and Development Agreement W81XWH-07-0029 between USAMRIID and Ichor Medical Systems. The opinions, interpretations, conclusions, and recommendations contained herein are those of the authors and are not necessarily endorsed by the U.S. Army. NR 13 TC 1 Z9 1 U1 1 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD JUN 30 PY 2016 VL 34 IS 31 BP 3607 EP 3612 DI 10.1016/j.vaccine.2016.04.077 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA DQ1IV UT WOS:000378955600008 PM 27206386 ER PT J AU Windham, AD Lowe, PM Conley, KW Netchaev, AD Buchanan, RK Buchanan, JP AF Windham, Amber D. Lowe, Patrick M. Conley, Keith W. Netchaev, Anton D. Buchanan, Randy K. Buchanan, J. Paige TI Controlled thiol-ene polymer microsphere production using a low-frequency acoustic excitation coaxial flow method SO POLYMER LA English DT Article DE Thiol-ene; Microspheres; Acoustic disturbance ID MONOMER FUNCTIONALITY; PHOTOPOLYMERIZATION; CHEMISTRY; SIZE; MICROFLUIDICS; NANOPARTICLES; FABRICATION; EXTRACTION; PARTICLES; NETWORKS AB A novel technique for the production of thiol-ene microspheres using acoustic resonance and coaxial flow is reported. The method utilizes low-frequency acoustically driven mechanical perturbations to disrupt the flow of a thiol-ene liquid jet, resulting in small thiol-ene droplets that are photochemically polymerized to yield thiol-ene microspheres. Tuning of the frequency, amplitude, and monomer solution viscosity are critical parameters impacting the diameter of the microspheres produced. Characterization by optical microscopy, scanning electron microscopy, and dynamic light scattering reveal microspheres of diameters <10 mu m, with narrow particle distributions. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Windham, Amber D.; Lowe, Patrick M.; Buchanan, J. Paige] Univ So Mississippi, Dept Chem & Biochem, 118 Coll Dr 5043, Hattiesburg, MS 39406 USA. [Conley, Keith W.] Univ So Mississippi, Sch Comp, Hattiesburg, MS 39406 USA. [Netchaev, Anton D.; Buchanan, Randy K.] US Army, Informat Technol Lab, Inst Syst Engn Res, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. RP Buchanan, JP (reprint author), Univ So Mississippi, Dept Chem & Biochem, 118 Coll Dr 5043, Hattiesburg, MS 39406 USA. EM paige.buchanan@usm.edu FU National Science Foundation CAREER Program [CHE-0847481]; NSF GK-12 Program-University of Southern Mississippi, "Connections in the Classroom: Molecules to Muscles" [0947944] FX Special thanks to Jessica Douglas for SEM imaging. Financial support for this work was provided through the National Science Foundation CAREER Program Award CHE-0847481 and the NSF GK-12 Program-University of Southern Mississippi, "Connections in the Classroom: Molecules to Muscles" Award 0947944. NR 37 TC 0 Z9 0 U1 3 U2 13 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 EI 1873-2291 J9 POLYMER JI Polymer PD JUN 28 PY 2016 VL 94 BP 8 EP 13 DI 10.1016/j.polymer.2016.03.086 PG 6 WC Polymer Science SC Polymer Science GA DM0WC UT WOS:000376065500002 ER PT J AU Turtle, L Bali, T Buxton, G Chib, S Chan, S Soni, M Hussain, M Isenman, H Fadnis, P Venkataswamy, MM Satishkumar, V Lewthwaite, P Kurioka, A Krishna, S Shankar, MV Ahmed, R Begum, A Ravi, V Desai, A Yoksan, S Fernandez, S Willberg, CB Kloverpris, HN Conlon, C Klenerman, P Satchidanandam, V Solomon, T AF Turtle, Lance Bali, Tanushka Buxton, Gemma Chib, Savita Chan, Sajesh Soni, Mohammed Hussain, Mohammed Isenman, Heather Fadnis, Prachi Venkataswamy, Manjunatha M. Satishkumar, Vishali Lewthwaite, Penny Kurioka, Ayako Krishna, Srinivasa Shankar, M. Veera Ahmed, Riyaz Begum, Ashia Ravi, Vasanthapuram Desai, Anita Yoksan, Sutee Fernandez, Stefan Willberg, Christian B. Kloverpris, Henrik N. Conlon, Christopher Klenerman, Paul Satchidanandam, Vijaya Solomon, Tom TI Human T cell responses to Japanese encephalitis virus in health and disease SO JOURNAL OF EXPERIMENTAL MEDICINE LA English DT Article ID DENGUE HEMORRHAGIC-FEVER; CROSS-REACTIVITY; NEUTRALIZING ANTIBODIES; INFECTION; PROTECTION; LYMPHOCYTES; CD4(+); CHALLENGE; SEQUENCE; IMMUNITY AB Japanese encephalitis (JE) virus (JEV) is an important cause of encephalitis in children of South and Southeast Asia. However, the majority of individuals exposed to JEV only develop mild symptoms associated with long-lasting adaptive immunity. The related flavivirus dengue virus (DENV) cocirculates in many JEV-endemic areas, and clinical data suggest cross-protection between DENV and JEV. To address the role of T cell responses in protection against JEV, we conducted the first full-breadth analysis of the human memory T cell response using a synthetic peptide library. Ex vivo interferon-gamma (IFN-gamma) responses to JEV in healthy JEV-exposed donors were mostly CD8(+) and targeted nonstructural (NS) proteins, whereas IFN-gamma responses in recovered JE patients were mostly CD4(+) and targeted structural proteins and the secreted protein NS1. Among patients, a high quality, polyfunctional CD4(+) T cell response was associated with complete recovery from JE. T cell responses from healthy donors showed a high degree of cross-reactivity to DENV that was less apparent in recovered JE patients despite equal exposure. These data reveal divergent functional CD4(+) and CD8(+) T cell responses linked to different clinical outcomes of JEV infection, associated with distinct targeting and broad flavivirus cross-reactivity including epitopes from DENV, West Nile, and Zika virus. C1 [Turtle, Lance; Buxton, Gemma; Isenman, Heather; Solomon, Tom] Univ Liverpool, Inst Infect & Global Hlth, Liverpool L69 7BE, Merseyside, England. [Turtle, Lance; Solomon, Tom] Univ Liverpool, Hlth Protect Res Unit Emerging & Zoonot Infect, Liverpool L69 7BE, Merseyside, England. [Turtle, Lance] Royal Liverpool Univ Hosp, Trop & Infect Dis Unit, Liverpool L7 8XP, Merseyside, England. [Bali, Tanushka; Chib, Savita; Chan, Sajesh; Soni, Mohammed; Satchidanandam, Vijaya] Indian Inst Sci, Dept Microbiol & Cell Biol, Bangalore 560012, Karnataka, India. [Hussain, Mohammed; Satishkumar, Vishali; Krishna, Srinivasa; Begum, Ashia] Vijayanagar Inst Med Sci, Coll Med, Dept Microbiol, Bellary 583104, India. [Satishkumar, Vishali; Shankar, M. Veera; Ahmed, Riyaz; Begum, Ashia] Vijayanagar Inst Med Sci, Coll Med, Dept Paediat, Bellary 583104, India. [Fadnis, Prachi; Venkataswamy, Manjunatha M.; Ravi, Vasanthapuram; Desai, Anita] Natl Inst Mental Hlth & Neurosci, Dept Neurovirol, Bangalore 560029, Karnataka, India. [Lewthwaite, Penny] Natl Hlth Serv Trust, St James Univ Hosp, Leeds Teaching Hosp, Dept Infect & Travel Med, Leeds LS9 7TF, W Yorkshire, England. [Kurioka, Ayako; Willberg, Christian B.; Kloverpris, Henrik N.; Conlon, Christopher; Klenerman, Paul] Univ Oxford, Peter Medawar Bldg Pathogen Res, Nuffield Dept Med, Oxford OX1 3SY, England. [Yoksan, Sutee] Mahidol Univ Salaya, Inst Mol Biosci, Ctr Vaccine Dev, Bangkok 73170, Thailand. [Fernandez, Stefan] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Solomon, Tom] Walton Ctr Natl Hlth Serv Fdn Trust, Liverpool L9 7LJ, Merseyside, England. [Chib, Savita] Natl Ctr Biol Sci, Bangalore 560065, Karnataka, India. [Kloverpris, Henrik N.] Univ KwaZulu Natal, KwaZulu Natal Res Inst TB & HIV, ZA-4001 Durban, South Africa. [Kloverpris, Henrik N.] Univ Copenhagen, Dept Immunol & Microbiol, DK-2200 Copenhagen, Denmark. RP Turtle, L (reprint author), Univ Liverpool, Inst Infect & Global Hlth, Liverpool L69 7BE, Merseyside, England.; Turtle, L (reprint author), Univ Liverpool, Hlth Protect Res Unit Emerging & Zoonot Infect, Liverpool L69 7BE, Merseyside, England.; Turtle, L (reprint author), Royal Liverpool Univ Hosp, Trop & Infect Dis Unit, Liverpool L7 8XP, Merseyside, England.; Satchidanandam, V (reprint author), Indian Inst Sci, Dept Microbiol & Cell Biol, Bangalore 560012, Karnataka, India.; Klenerman, P (reprint author), Univ Oxford, Peter Medawar Bldg Pathogen Res, Nuffield Dept Med, Oxford OX1 3SY, England. EM lturtle@liverpool.ac.uk; paul.klenerman@medawar.ox.ac.uk; vijaya@mcbl.iisc.ernet.in OI Turtle, Lance/0000-0002-0778-1693; Willberg, Christian/0000-0001-5299-9344 FU National Institutes of Health Tetramer Core Facility [HHSN272201300006C]; National Institute of Allergy and Infectious Diseases, National Institutes of Health, and Department of Health and Human Services [HHSN272201400028C]; Wellcome Trust [087757/Z/08/Z]; National Institute for Health Research, UK; Wellcome Trust the National Institute for Health Research biomedical research center, Oxford [WT091663MA]; Oxford Martin School; Health Protection Research Unit in Emerging Infections and Zoonoses of the National Institute for Health Research [HPRU-2012-10117] FX We acknowledge the National Institutes of Health Tetramer Core Facility (contract HHSN272201300006C) for provision of MHC class I tetramers and the Biodefense and Emerging Infections Research Resources Repository and the National Institute of Allergy and Infectious Diseases for provision of DENV and WNV peptide libraries. The Virus Pathogen Database and Analysis Resource has been wholly funded with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, and Department of Health and Human Services under contract HHSN272201400028C. We thank Prof. Phillip Goulder for the gift of B cell lines. We thank the director, patients, relatives, and staff at VIMS Medical College Hospital and all the volunteers who took part.; This work was funded by a Wellcome Trust fellowship (087757/Z/08/Z) to L. Turtle (currently funded by the National Institute for Health Research, UK). P. Klenerman is a Wellcome Trust Senior Clinical Fellow (WT091663MA) funded through the National Institute for Health Research biomedical research center, Oxford, and the Oxford Martin School. T. Solomon is supported by the Health Protection Research Unit in Emerging Infections and Zoonoses of the National Institute for Health Research (HPRU-2012-10117). NR 64 TC 2 Z9 2 U1 47 U2 50 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 950 THIRD AVE, 2ND FLR, NEW YORK, NY 10022 USA SN 0022-1007 EI 1540-9538 J9 J EXP MED JI J. Exp. Med. PD JUN 27 PY 2016 VL 213 IS 7 BP 1331 EP 1352 DI 10.1084/jem.20151517 PG 22 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA DS5VA UT WOS:000380849800018 PM 27242166 ER PT J AU Britton, JW Bohnet, JG Sawyer, BC Uys, H Biercuk, MJ Bollinger, JJ AF Britton, J. W. Bohnet, J. G. Sawyer, B. C. Uys, H. Biercuk, M. J. Bollinger, J. J. TI Vibration-induced field fluctuations in a superconducting magnet SO PHYSICAL REVIEW A LA English DT Article ID ATOMIC MASS MEASUREMENTS; PENNING TRAP; ELECTRON AB Superconducting magnets enable precise control of nuclear and electron spins, and are used in experiments that explore biological and condensed-matter systems, and fundamental atomic particles. In high-precision applications, a common view is that slow (<1 Hz) drift of the homogeneous magnetic-field limits control and measurement precision. We report on previously undocumented higher-frequency field noise (10-200 Hz) that limits the coherence time of Be-9(+) electron-spin qubits in the 4.46-T field of a superconducting magnet. We measure a spin-echo T-2 coherence time of similar to 6 ms for the Be-9(+) electron-spin resonance at 124 GHz, limited by part-per-billion fractional fluctuations in the magnet's homogeneous field. Vibration isolation of the magnet improved T-2 to similar to 50 ms. C1 [Britton, J. W.; Bohnet, J. G.; Bollinger, J. J.] NIST, Div Time & Frequency, Boulder, CO 80305 USA. [Britton, J. W.] Army Res Lab, Adelphi, MD 20783 USA. [Sawyer, B. C.] Georgia Tech Res Inst, Atlanta, GA 30332 USA. [Uys, H.] Univ Stellenbosch, Dept Phys, ZA-7600 Stellenbosch, South Africa. [Uys, H.] CSIR, Natl Laser Ctr, ZA-0184 Pretoria, South Africa. [Biercuk, M. J.] Univ Sydney, Sch Phys, ARC Ctr Engn Quantum Syst, Sydney, NSW 2006, Australia. RP Britton, JW (reprint author), NIST, Div Time & Frequency, Boulder, CO 80305 USA.; Britton, JW (reprint author), Army Res Lab, Adelphi, MD 20783 USA. EM joe.britton@gmail.com FU DARPA OLE; NIST FX We acknowledge financial support from DARPA OLE and NIST. The authors thank S. Lyon and G. Morley for very useful discussions on solid-state ESR experiments, and J. Savory and S. Russek for their comments on the paper. This work includes contributions by NIST and as such is not subject to U.S. copyright. NR 28 TC 2 Z9 2 U1 1 U2 2 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9926 EI 2469-9934 J9 PHYS REV A JI Phys. Rev. A PD JUN 27 PY 2016 VL 93 IS 6 AR 062511 DI 10.1103/PhysRevA.93.062511 PG 7 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA DP9FS UT WOS:000378802700013 ER PT J AU Hu, YJ Shang, SL Wang, Y Darling, KA Butler, BG Kecskes, LJ Liu, ZK AF Hu, Yong-Jie Shang, Shun-Li Wang, Yi Darling, Kristopher A. Butler, Brady G. Kecskes, Laszlo J. Liu, Zi-Kui TI Effects of alloying elements and temperature on the elastic properties of W-based alloys by first-principles calculations SO JOURNAL OF ALLOYS AND COMPOUNDS LA English DT Article DE First-principles calculations; Tungsten-based alloys; Elastic properties; Quasi-static approach; Electronic structure ID ELECTRON-GAS; RHENIUM; METALS; TUNGSTEN; ENERGY; NI; PARAMETERS; NI3AL; MODEL; MG AB The influence of various transition alloying elements (X's) on the elastic properties of W-based alloys has been studied via first-principles calculations on the basis of density functional theory. Here, nineteen transition metal alloying elements (X) are considered: Ti, V, Cr, Fe, Co, Ni, Y, Zr, Nb, Mo, Ru, Rh, Pd, Hf, Ta, Re, Os, Ir, and Pt. It is found that (i) the bulk modulus of the dilute W-X alloy decreases with increasing its equilibrium volume, particularly, for the alloying elements in the same period; (ii) all of the alloying elements decrease the shear modulus of BCC W; and (iii) the largest decrease of elastic properties of W is due to alloying element Y. In addition, it is shown that the changes of elastic properties of W caused by the alloying elements are traceable from the electron charge density distribution, resulting in a bonding distortion between W and the alloying atoms. Using the quasi-static approach based on the Debye model, the elastic properties of these W-X alloys at finite temperatures are predicted. Calculated properties of BCC W and the W-X alloys are in favorable agreement with available experimental measurements. (C) 2016 Elsevier B.V. All rights reserved. C1 [Hu, Yong-Jie; Shang, Shun-Li; Wang, Yi; Liu, Zi-Kui] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. [Darling, Kristopher A.; Butler, Brady G.; Kecskes, Laszlo J.] US Army Res Lab, Weap & Mat Res Directorate, RDRL WMM F, Aberdeen Proving Ground, MD 21005 USA. RP Hu, YJ (reprint author), Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. EM yoh5120@psu.edu RI Shang, Shun-Li/A-6564-2009; Wang, Yi/D-1032-2013; Liu, Zi-Kui/A-8196-2009 OI Shang, Shun-Li/0000-0002-6524-8897; Liu, Zi-Kui/0000-0003-3346-3696 FU U.S. Army Research Laboratory [W911NF-08-2-0084]; National Science Foundation [ACI-1053575]; Materials Simulation Center; Institute for CyberScience FX The financial support from the U.S. Army Research Laboratory under contract W911NF-08-2-0084 is greatly acknowledged. This work is also supported in part by a grant of computer time from the DoD High Performance Computing Modernization Program at U.S. Air Force Research Laboratory (ARFL) DoD Supercomputing Resource Center (DSRC). First-principles calculations also partially used the Extreme Science and Engineering Discovery Environment (XSEDE), which is supported by National Science Foundation Grant No. ACI-1053575, and were partially carried out on the LION clusters at the Pennsylvania State University supported by the Materials Simulation Center and the Institute for CyberScience. Lastly, we would like to thank Dr. Bi-Cheng Zhou and Dr. Xuan Liu in the Phases Research Laboratory at the Pennsylvania State University for stimulating discussions. NR 41 TC 1 Z9 1 U1 12 U2 60 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0925-8388 EI 1873-4669 J9 J ALLOY COMPD JI J. Alloy. Compd. PD JUN 25 PY 2016 VL 671 BP 267 EP 275 DI 10.1016/j.jallcom.2016.02.018 PG 9 WC Chemistry, Physical; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Chemistry; Materials Science; Metallurgy & Metallurgical Engineering GA DG0PP UT WOS:000371767900034 ER PT J AU Burnouf, T Conton, B Dye, JM AF Burnouf, Thierry Conton, Brian Dye, John M. CA GET Consortium TI Convalescent Plasma for Ebola Virus Disease SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter C1 [Burnouf, Thierry] Taipei Med Univ, Taipei, Taiwan. [Conton, Brian] Physiofitness & Rehabil Ctr, Freetown, Sierra Leone. [Dye, John M.] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. RP Burnouf, T (reprint author), Taipei Med Univ, Taipei, Taiwan. EM thburnouf@gmail.com NR 3 TC 1 Z9 1 U1 4 U2 4 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD JUN 23 PY 2016 VL 374 IS 25 BP 2499 EP 2499 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA DP1TG UT WOS:000378271700019 PM 27332915 ER PT J AU Agarwal, S Fulgoni, VL Lieberman, HR AF Agarwal, Sanjiv Fulgoni, Victor L., III Lieberman, Harris R. TI Assessing alcohol intake & its dose-dependent effects on liver enzymes by 24-h recall and questionnaire using NHANES 2001-2010 data SO NUTRITION JOURNAL LA English DT Article DE Alkaline phosphatase; Alanine aminotransferase; Aspartate aminotransferase; Gamma glutamyl transferase; Bilirubin; NCI method ID GAMMA-GLUTAMYL-TRANSFERASE; CORONARY-HEART-DISEASE; UNITED-STATES; METABOLIC SYNDROME; MODERATE DRINKERS; SUBJECTIVE HEALTH; DRINKING PATTERN; CONSUMPTION; RISK; MORTALITY AB Background: Alcohol is a significant component of the diet with dose-dependent risks and benefits. High doses of alcohol damage the liver and early symptoms of liver disease include changes in routinely assessed liver enzymes. Less is known regarding the mechanisms responsible for the benefits of moderate alcohol consumption, including their effects on the liver. The objectives of this study were to examine alcohol's dose-dependent effects on markers of liver function (alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transferase (GGT), and bilirubin), as well as to compare the different methods of assessing alcohol intake using NHANES 2001-2010 adult data (N = 24,807). Methods: Three methods were used to estimate alcohol intake from all volunteers: 24-h recall; the National Cancer Institute (NCI) method of usual intake; and a specific alcohol intake questionnaire. Results: Mean alcohol intake by 24-h recall, NCI method and questionnaire was 41.0 +/- 0.8 g/d, 10.9 +/- 0.2 g/d and 11.0 +/- 0.2 g/d, respectively. Alcohol consumers had significantly lower levels of ALP and higher levels of AST, GGT and bilirubin compared to non-consumers (P < 0.01) and activities of ALT, AST, and GGT increased and of ALP decreased as alcohol intake increased, regardless of intake assessment method used. The most sensitive measure of alcohol consumption was GGT. Conclusions: Since alcohol had a graded linear effect on several liver enzymes, including at low and moderate doses, benefits as well as risks of alcohol intake may be related to liver function. Since the NCI method and alcohol questionnaire yielded very similar alcohol intake estimates, this study cross-validated these methods and demonstrated the robustness of the NCI method for estimating intake of irregularly consumed foods. C1 [Lieberman, Harris R.] US Army, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Agarwal, Sanjiv; Fulgoni, Victor L., III] Oak Ridge Inst Sci & Educ, Belcamp, MD 21017 USA. [Fulgoni, Victor L., III] Henry M Jackson Fdn, Bethesda, MD 20817 USA. RP Lieberman, HR (reprint author), US Army, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. EM harris.r.lieberman.civ@mail.mil FU U.S. Army Medical Research and Material Command; Department of Defense Center Alliance for Dietary Supplement Research FX The views, opinions, and findings in this report are those of the authors and should not be construed as an official Department of Defense or Army position, policy, or decision, unless so designated by other official documentation. Citations of commercial organizations and trade names in this report do not constitute an official Department of the Army endorsement or approval of the products or services of these organizations. The investigators have adhered to the policies for protection of human subjects as prescribed in DOD Instruction 3216.02 and the research was conducted in adherence with the provisions of 32 CFR Part 219. We thank U.S. Army Medical Research and Material Command and Department of Defense Center Alliance for Dietary Supplement Research for funding the research. This research was also supported in part by an appointment to the Research Participation Program at the U.S. Army Medical Research Institute of Environmental Medicine administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USAMRMC. NR 46 TC 0 Z9 0 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2891 J9 NUTR J JI Nutr. J. PD JUN 22 PY 2016 VL 15 AR 62 DI 10.1186/s12937-016-0180-y PG 12 WC Nutrition & Dietetics SC Nutrition & Dietetics GA DQ6DP UT WOS:000379294600001 PM 27334005 ER PT J AU Wu, ZZ Ji, SP Hu, ZX Zheng, JX Xiao, S Lin, Y Xu, K Amine, K Pan, F AF Wu, Zhongzhen Ji, Shunping Hu, Zongxiang Zheng, Jiaxin Xiao, Shu Lin, Yuan Xu, Kang Amine, Khalil Pan, Feng TI Pre-Lithiation of Li(Ni1-x-yMnxCoy)O-2 Materials Enabling Enhancement of Performance for Li-Ion Battery SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE pre-lithiation; Li(NixMnyCoz)O-2 (NMCxyz); ab initio calculations; double-layered Li structure; cycling stability and capacity ID TOTAL-ENERGY CALCULATIONS; AUGMENTED-WAVE METHOD; CATHODE MATERIALS; HIGH-CAPACITY; BASIS-SET; LITHIUM; ELECTRODES AB Transition metal oxide materials Li(NixMnyCoz)O-2 (NMCxyz) based on layered structure are potential cathode candidates for automotive Li-ion batteries because of their high specific capacities and operating. potentials. However, the actual usable capacity, cycling stability, and first-cycle Coulombic efficiency remain far from practical. Previously, we reported a combined strategy consisting of depolarization with embedded carbon nanotube (CNT) and activation through pre-lithiation of the NMC host, which significantly improved the reversible capacity and cycling stability of NMC532-based material. In the present work we attempt to understand how pre-lithiation leads to these improvements on an atomic level with experimental investigation and ab initio calculations. By lithiating a series of NMC materials with varying chemical compositions prepared via a conventional approach, we identified the Ni in the NMC lattice as the component responsible for accommodating a double-layered Li structure. Specifically, much better improvements in the cycling stability and capacity can be achieved with the NMC lattices populated with Ni3+ than those populated with only Ni2+ Using the XRD we also found that the emergence of a double-layer Li structure is not only reversible during the pre-lithiation and the following delithiation, but also stable against elevated temperatures up to 320 degrees C. These new findings regarding the mechanism of pre-lithiation as well as how it affects the reversibility and stability of NMC-based cathode "materials prepared by the conventional slurry approach will promote the possibility of their application in the future battery industry. C1 [Wu, Zhongzhen; Ji, Shunping; Hu, Zongxiang; Zheng, Jiaxin; Xiao, Shu; Lin, Yuan; Pan, Feng] Peking Univ, Shenzhen Grad Sch, Sch Adv Mat, Shenzhen 518055, Peoples R China. [Xu, Kang] US Army Res Lab, Adelphi, MD 20783 USA. [Amine, Khalil] Argonne Natl Lab, Chem Sci & Engn Div, Electrochem Technol Program, 9700 S Cass Ave, Argonne, IL 60439 USA. RP Pan, F (reprint author), Peking Univ, Shenzhen Grad Sch, Sch Adv Mat, Shenzhen 518055, Peoples R China. EM panfeng@pkusz.edu.cn FU National Science Foundation of China [51301004]; Guangdong Innovation Team Project [2013N080]; Shenzhen Peacock Plan [KYPT20141016105435850]; Shenzhen Science and Technology Research Grant [JCYJ20140903102215536, JCYJ20150828093127698, ZDSY20130331145131323] FX This work was financially supported jointly by National Science Foundation of China (No. 51301004), Guangdong Innovation Team Project (No. 2013N080), Shenzhen Peacock Plan (Grant No. KYPT20141016105435850), and Shenzhen Science and Technology Research Grant (No. JCYJ20140903102215536, JCYJ20150828093127698 and ZDSY20130331145131323). NR 23 TC 1 Z9 1 U1 19 U2 34 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD JUN 22 PY 2016 VL 8 IS 24 SI SI BP 15361 EP 15368 DI 10.1021/acsami.6b03730 PG 8 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA DP6CP UT WOS:000378584800052 PM 27237226 ER PT J AU Limantol, AM Keith, BE Azabre, BA Lennartz, B AF Limantol, Andrew Manoba Keith, Bruce Edward Azabre, Bismark Atiayure Lennartz, Bernd TI Farmers' perception and adaptation practice to climate variability and change: a case study of the Vea catchment in Ghana SO SPRINGERPLUS LA English DT Article DE Climate change; Farmers' perception; Adaptations; Barriers; Vea catchment ID RAINFALL; IMPACTS; AFRICA; CHINA AB Background: Rain-fed agriculture remains the source of employment for a majority of Ghana's population, particularly in northern Ghana where annual rainfall is low. The purpose of this study is to examine farmers' perceptions and adaptation practices to climate change and variability in accordance with actual recorded weather data of the Vea catchment in Upper East Region of northern Ghana during the time interval from 1972 to 2012. Methods: Climatic data over 41-years (1972-2012) from four stations in vicinity of the catchment was evaluated to identify actual weather outcomes. A survey questionnaire targeting farmers with at least 30-years of farming experience in the area was administered in six of the eleven agricultural enumeration areas in the catchment covering 305 km(2). Of the 466 farmers interviewed, 79 % utilized rain-fed practices while 21 % utilized some form of irrigation. Results: Results indicate that nearly 90 % of the farmers interviewed believe that temperature increased over the past 30-years, while over 94 % of the farmers believe that amount of rainfall, duration, intensity and rainy days has decreased. Nearly 96 % of the farmers believe that their farms are extremely vulnerable to decreased rainfall, droughts and changed timing of rainfall events. Climatic data of the catchment indicates a rising trend in temperature but no long-term changes in annual and monthly rainfall, thereby possibly increasing levels of evapotranspiration. While no statistical differences were found between rain-fed and irrigation agricultural types regarding receipt of external support, their approaches to climatic change adaptation do differ. Patently, 94 and 90 % of farmers relying on rain-fed and irrigation strategies respectively receive some form of support, primarily via extension services. Farmers using rain-fed practices adjust to climate variability by varying crop types via rotation without fertilizer while farmers employing irrigation practices are more likely to offset climate variability with a greater use of fertilizer application. Conclusion: The Vea catchment faces rising temperature and evapotranspiration trends. Farmers are aware of these climatic changes and are adapting strategies to cope with the effects but require support. Adequate extension services and irrigation facilities are needed to assist farmers in order to sustain their livelihoods on the long run. C1 [Limantol, Andrew Manoba] Univ Abomey Calavi, West African Sci Serv Ctr Climate Change & Adapte, Grad Res Program GRP Climate Change & Water Resou, Cotonou, Benin. [Keith, Bruce Edward] US Mil Acad, Ctr Nation Reconstruct & Capac Dev, Dept Syst Engn, West Point, NY 10996 USA. [Azabre, Bismark Atiayure] Univ Dev Studies, Planning & Management Dept, Wa Campus, Wa, Ghana. [Lennartz, Bernd] Univ Rostock, Agr & Environm Sci, D-18055 Rostock, Germany. RP Limantol, AM (reprint author), Univ Abomey Calavi, West African Sci Serv Ctr Climate Change & Adapte, Grad Res Program GRP Climate Change & Water Resou, Cotonou, Benin. EM limantol@yahoo.co.uk FU German Ministry of Education and Research (BMBF) FX This work has been conducted as part of a doctorate research scholarship under West African Science Service Center on Climate Change and Adapted Land Use (WASCAL) project funded by the German Ministry of Education and Research (BMBF). The funders had no role in the design of the study and collection, analysis, and interpretation of data and in preparation of the manuscript, or decision to publish. NR 63 TC 0 Z9 0 U1 19 U2 25 PU SPRINGER INTERNATIONAL PUBLISHING AG PI CHAM PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND SN 2193-1801 J9 SPRINGERPLUS JI SpringerPlus PD JUN 22 PY 2016 VL 5 AR 830 DI 10.1186/s40064-016-2433-9 PG 38 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DP4OJ UT WOS:000378475000007 PM 27386279 ER PT J AU Buchler, N Fitzhugh, SM Marusich, LR Ungvarsky, DM Lebiere, C Gonzalez, C AF Buchler, Norbou Fitzhugh, Sean M. Marusich, Laura R. Ungvarsky, Diane M. Lebiere, Christian Gonzalez, Cleotilde TI Mission Command in the Age of Network-Enabled Operations: Social Network Analysis of Information Sharing and Situation Awareness SO FRONTIERS IN PSYCHOLOGY LA English DT Article DE network organization; sociotechnical system; Pareto principle; communication exponential random graph model; homophily; degree distribution; training effectiveness ID EXPONENTIAL FAMILY MODELS; PERFORMANCE; FLOW AB A common assumption in organizations is that information sharing improves situation awareness and ultimately organizational effectiveness. The sheer volume and rapid pace of information and communications received and readily accessible through computer networks, however, can overwhelm individuals, resulting in data overload from a combination of diverse data sources, multiple data formats, and large data volumes. The current conceptual framework of network enabled operations (NEO) posits that robust networking and information sharing act as a positive feedback loop resulting in greater situation awareness and mission effectiveness in military operations (Alberts and Garstka, 2004). We test this assumption in a large-scale, 2-week military training exercise. We conducted a social network analysis of email communications among the multi-echelon Mission Command staff (one Division and two sub-ordinate Brigades) and assessed the situational awareness of every individual. Results from our exponential random graph models challenge the aforementioned assumption, as increased email output was associated with lower individual situation awareness. It emerged that higher situation awareness was associated with a lower probability of out-ties, so that broadly sending many messages decreased the likelihood of attaining situation awareness. This challenges the hypothesis that increased information sharing improves situation awareness, at least for those doing the bulk of the sharing. In addition, we observed two trends that reflect a compartmentalizing of networked information sharing as email links were more commonly formed among members of the command staff with both similar functions and levels of situation awareness, than between two individuals with dissimilar functions and levels of situation awareness; both those findings can be interpreted to reflect effects of homophily. Our results have major implications that challenge the current conceptual framework of NEO. In addition, the information sharing network was largely imbalanced and dominated by a few key individuals so that most individuals in the network have very few email connections, but a small number of individuals have very many connections. These results highlight several major growing pains for networked organizations and military organizations in particular. C1 [Buchler, Norbou; Fitzhugh, Sean M.; Marusich, Laura R.; Ungvarsky, Diane M.] US Army, Res Labs, Aberdeen Proving Ground, MD USA. [Lebiere, Christian; Gonzalez, Cleotilde] Carnegie Mellon Univ, Dept Social & Decis Sci, Pittsburgh, PA 15213 USA. RP Buchler, N (reprint author), US Army, Res Labs, Aberdeen Proving Ground, MD USA. EM norbou.buchler.civ@mail.mil FU Network Science Collaborative Technology Alliance - U.S. Army Research Laboratory [W911N17-09-2-0053] FX This research was supported by the Network Science Collaborative Technology Alliance sponsored by the U.S. Army Research Laboratory under Cooperative Agreement No. W911N17-09-2-0053 and by two appointments to the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the U.S. Army Research Laboratory or the U.S. Government. NR 75 TC 0 Z9 0 U1 7 U2 10 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1664-1078 J9 FRONT PSYCHOL JI Front. Psychol. PD JUN 22 PY 2016 VL 7 AR 937 DI 10.3339/fpsyg.2016.00937 PG 15 WC Psychology, Multidisciplinary SC Psychology GA DP2GS UT WOS:000378306900001 PM 27445905 ER PT J AU Appel, AS McDonough, JH McMonagle, JD Logue, BA AF Appel, Amanda S. McDonough, John H. McMonagle, Joseph D. Logue, Brian A. TI Analysis of Nerve Agent Metabolites from Hair for Long-Term Verification of Nerve Agent Exposure SO ANALYTICAL CHEMISTRY LA English DT Article ID CHROMATOGRAPHY-MASS SPECTROMETRY; ISOPROPYL METHYLPHOSPHONIC ACID; FACILITATED SEXUAL ASSAULT; SOLID-PHASE EXTRACTION; HUMAN SERUM; HUMAN BUTYRYLCHOLINESTERASE; GAS-CHROMATOGRAPHY; BIOLOGICAL SAMPLES; ISOTOPE-DILUTION; RETROSPECTIVE DETECTION AB Several methods for the bioanalysis of nerve agents or their metabolites have been developed for the verification of nerve agent exposure. However, parent nerve agents and known metabolites are generally rapidly excreted from biological matrixes typically used for analysis (i.e., blood, urine, and tissues), limiting the amount of time after an exposure that verification is feasible. In this study, hair was evaluated as a long-term repository of nerve agent hydrolysis products. Pinacolyl methylphosphonic acid (PMPA; hydrolysis product of soman) and isopropyl methylphosphonic acid (IMPA; hydrolysis product of sarin) were extracted from hair samples with N,N-dimethylformamide and subsequently analyzed by liquid chromatography tandem mass spectrometry. Limits of detection for PMPA and IMPA were 0.15 mu g/kg and 7.5 mu g/kg and linear ranges were 0.3-150 mu g/kg and 7.5-750 mu g/kg, respectively. To evaluate the applicability of the method to verify nerve agent exposure well after the exposure event, rats were exposed to soman, hair was collected after approximately 30 days, and stored for up to 3.5 years prior to initial analysis. PMPA was positively identified in 100% of the soman-exposed rats (N = 8) and was not detected in any of the saline treated animals (N = 6). The hair was reanalyzed 5.5 years after exposure and PMPA was detected in 6 of the 7 (one of the soman-exposed hair samples was completely consumed in the analysis at 3.5 years) rat hair samples (with no PMPA detected in the saline exposed animals). Although analysis of CVVA metabolites from hair via this technique is not appropriate as a universal method to determine exposure (i.e., it takes time for the hair to grow above the surface of the skin and typical analysis times are >24 h), it complements existing methods and could become the preferred method for verification of exposure if 10 or more days have elapsed after a suspected exposure. C1 [Appel, Amanda S.; Logue, Brian A.] S Dakota State Univ, Dept Chem & Biochem, Avera Hlth & Sci, Box 2202, Brookings, SD 57007 USA. [McDonough, John H.; McMonagle, Joseph D.] US Army Med Res Inst Chem Def, Pharmacol Branch, Div Res, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. RP Logue, BA (reprint author), S Dakota State Univ, Dept Chem & Biochem, Avera Hlth & Sci, Box 2202, Brookings, SD 57007 USA. EM brian.logue@sdstate.edu FU Defense Threat Reduction Agency [HDTRA-1-07-00026]; Medical Research and Materiel Command Broad Agency Announcement; South Dakota State University Research Support Fund; Defense Threat Reduction Agency Joint Science and Technology Office, Medical ST Division; National Science Foundation Major Research Instrumentation Program [CHE-0922816]; state of South Dakota; South Dakota State University [AB SCIEX QTRAP 5500 LC-MS/MS]; National Science Foundation/EPSCoR [0091948] FX This research was supported by the Defense Threat Reduction Agency under Contract HDTRA-1-07-00026, through the Medical Research and Materiel Command Broad Agency Announcement, and the South Dakota State University Research Support Fund. Animal studies were supported by the Defense Threat Reduction Agency Joint Science and Technology Office, Medical S&T Division. We thank the National Science Foundation Major Research Instrumentation Program (Grant Number CHE-0922816), the state of South Dakota, and South Dakota State University for funding the AB SCIEX QTRAP 5500 LC-MS/MS. The LC-MS/MS instrumentation was housed in the South Dakota State University Campus Mass Spectrometry Facility, which was supported by the National Science Foundation/EPSCoR Grant No. 0091948 and the State of South Dakota. The authors would also like to thank the U.S. Army Medical Research Institute for Chemical Defense, including the laboratories of Carl D. Smith and Todd M. Myers for providing animal hair for testing. Additionally, the authors would like to thank Bruce Gray and Fred DeRoos at the University of South Dakota for assistance with preliminary work on a GC/MS/MS method for the soman and sarin metabolites. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of Defense, the National Science Foundation, or the State of South Dakota. NR 70 TC 1 Z9 1 U1 4 U2 8 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 EI 1520-6882 J9 ANAL CHEM JI Anal. Chem. PD JUN 21 PY 2016 VL 88 IS 12 BP 6523 EP 6530 DI 10.1021/acs.analchem.6b01274 PG 8 WC Chemistry, Analytical SC Chemistry GA DP4MO UT WOS:000378470200061 PM 27161086 ER PT J AU Gray, KA Gresty, KJ Chen, NH Zhang, V Gutteridge, CE Peatey, CL Chavchich, M Waters, NC Cheng, Q AF Gray, Karen-Ann Gresty, Karryn J. Chen, Nanhua Zhang, Veronica Gutteridge, Clare E. Peatey, Christopher L. Chavchich, Marina Waters, Norman C. Cheng, Qin TI Correlation between Cyclin Dependent Kinases and Artemisinin-Induced Dormancy in Plasmodium falciparum In Vitro SO PLOS ONE LA English DT Article ID HUMAN MALARIA PARASITES; CELL-CYCLE; PROTEIN-KINASE; CDC2-RELATED KINASE; PFMRK; CDK; INHIBITORS; EXPRESSION; DISCOVERY; IDENTIFICATION AB Background Artemisinin-induced dormancy provides a plausible explanation for recrudescence following artemisinin monotherapy. This phenomenon shares similarities with cell cycle arrest where cyclin dependent kinases (CDKs) and cyclins play an important role. Methods Transcription profiles of Plasmodium falciparum CDKs and cyclins before and after dihydroartemisinin (DHA) treatment in three parasite lines, and the effect of CDK inhibitors on parasite recovery from DHA-induced dormancy were investigated. Results After DHA treatment, parasites enter a dormancy phase followed by a recovery phase. During the dormancy phase parasites up-regulate pfcrk1, pfcrk4, pfcyc2 and pfcyc4, and down-regulate pfmrk, pfpk5, pfpk6, pfcrk3, pfcyc1 and pfcyc3. When entering the recovery phase parasites immediately up-regulate all CDK and cyclin genes. Three CDK inhibitors, olomoucine, WR636638 and roscovitine, produced distinct effects on different phases of DHA-induced dormancy, blocking parasites recovery. Conclusions The up-regulation of PfCRK1 and PfCRK4, and down regulation of other CDKs and cyclins correlate with parasite survival in the dormant state. Changes in CDK expression are likely to negatively regulate parasite progression from G1 to S phase. These findings provide new insights into the mechanism of artemisinin-induced dormancy and cell cycle regulation of P. falciparum, opening new opportunities for preventing recrudescence following artemisinin treatment. C1 [Gray, Karen-Ann; Gresty, Karryn J.; Chen, Nanhua; Zhang, Veronica; Peatey, Christopher L.; Chavchich, Marina; Cheng, Qin] Australian Army Malaria Inst, Drug Resistance & Diagnost, Brisbane, Qld, Australia. [Gray, Karen-Ann; Gresty, Karryn J.; Peatey, Christopher L.; Cheng, Qin] QIMR Berghofer Med Res Inst, Clin Trop Med, Brisbane, Qld, Australia. [Zhang, Veronica] Univ Queensland, Sch Biochem, Brisbane, Qld, Australia. [Gutteridge, Clare E.] US Naval Acad, Annapolis, MD 21402 USA. [Waters, Norman C.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Cheng, Q (reprint author), Australian Army Malaria Inst, Drug Resistance & Diagnost, Brisbane, Qld, Australia.; Cheng, Q (reprint author), QIMR Berghofer Med Res Inst, Clin Trop Med, Brisbane, Qld, Australia.; Waters, NC (reprint author), Walter Reed Army Inst Res, Silver Spring, MD USA. EM noman.c.waters2.mil@mail.mil; qin.cheng@defence.gov.au FU NHMRC, Australia [GNT1021273] FX The work was partially funded by NHMRC, Australia (GNT1021273). NC, CP, MC and QC are employees of the Department of Defence, Australia. CEG and NCW are employees of Department of Defense, USA. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. NR 48 TC 0 Z9 0 U1 1 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUN 21 PY 2016 VL 11 IS 6 AR e0157906 DI 10.1371/journal.pone.0157906 PG 14 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DP0WU UT WOS:000378212400061 PM 27326764 ER PT J AU Farooq, F Beck, K Paolino, KM Phillips, R Waters, NC Regules, JA Bergmann-Leitner, ES AF Farooq, Fouzia Beck, Kevin Paolino, Kristopher M. Phillips, Revell Waters, Norman C. Regules, Jason A. Bergmann-Leitner, Elke S. TI Circulating follicular T helper cells and cytokine profile in humans following vaccination with the rVSV-ZEBOV Ebola vaccine SO SCIENTIFIC REPORTS LA English DT Article ID VESICULAR STOMATITIS-VIRUS; NONHUMAN-PRIMATES; HEMORRHAGIC-FEVER; TFH CELLS; IMMUNIZATION; CHALLENGE; RESPONSES; IMMUNITY; AVIDITY; DISEASE AB The most recent Zaire Ebolavirus (ZEBOV) outbreak was the largest and most widespread in recorded history, emphasizing the need for an effective vaccine. Here, we analyzed human cellular immune responses induced by a single dose of the rVSV-ZEBOV vaccine candidate, which showed significant protective efficacy in endemic populations in Guinea. This is the first in-depth characterization of ZEBOV-GP specific, circulating follicular T cells (cTfh). Since antibody titers correlated with protection in preclinical models of ZEBOV infection, Tfh were predicted to correlate with protection. Indeed, the ZEBOV-specific cTfh data correlated with antibody titers in human vaccines and unexpectedly with the Tfh17 subset. The combination of two cutting edge technologies allowed the immuno-profiling of rare cell populations and may help elucidate correlates of protection for a variety of vaccines. C1 [Farooq, Fouzia; Waters, Norman C.; Bergmann-Leitner, Elke S.] Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD 20910 USA. [Beck, Kevin] Miltenyi Biotec Inc, San Diego, CA 92121 USA. [Paolino, Kristopher M.] Walter Reed Army Inst Res, Clin Trials Ctr, Silver Spring, MD 20910 USA. [Phillips, Revell] Def Threat Reduct Agcy, Joint Sci & Technol Off, Chem & Biol Def Program, Med Vaccine Branch, Ft Belvoir, VA 22060 USA. [Regules, Jason A.] US Army, Dept Clin Res, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Bergmann-Leitner, ES (reprint author), Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD 20910 USA. EM elke.s.bergmann-leitner.civ@mail.mil FU DTRA [HDTRA1516358] FX We would like to thank Dr Brian K. Martin and Dr. David Hone (DTRA); funding was provided by DTRA (HDTRA1516358). We would like to thank Dr. Donald G. Heppner and Dr. Thomas P. Monath (NewLink Genetics Corp) for critically reviewing the manuscript. We would like to thank Dr. Sidhartha Chaudhury (Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center) for providing statistical support. We would like to thank Ms. Rebecca Kurnat, Joint Vaccine Acquisition Program for providing peptides for the initial phase of the work and Ms. Tanisha Robinson for technical assistance. The opinions or assertions contained herein are the private views of the authors, and are not to be construed as official, or as reflecting true views of the Department of the Army or the Department of Defense. NR 34 TC 2 Z9 2 U1 7 U2 9 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD JUN 21 PY 2016 VL 6 AR 27944 DI 10.1038/srep27944 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DP1EH UT WOS:000378232800001 PM 27323685 ER PT J AU Majji, S Wijayalath, W Shashikumar, S Pow-Sang, L Villasante, E Brumeanu, TD Casares, S AF Majji, Sai Wijayalath, Wathsala Shashikumar, Soumya Pow-Sang, Luis Villasante, Eileen Brumeanu, Teodor D. Casares, Sofia TI Differential effect of HLA class-I versus class-II transgenes on human T and B cell reconstitution and function in NRG mice SO SCIENTIFIC REPORTS LA English DT Article ID RESTRICTED IMMUNE-RESPONSES; VIRUS-INFECTION; GAMMA-CHAIN; DRAG MICE; NOG MICE; LYMPHOCYTES; PROTEIN; ACTIVATION; EXPRESSION; INDUCTION AB Humanized mice expressing Human Leukocyte Antigen (HLA) class I or II transgenes have been generated, but the role of class I vs class II on human T and B cell reconstitution and function has not been investigated in detail. Herein we show that NRG (NOD.RagKO.IL2R gamma cKO) mice expressing HLA-DR4 molecules (DRAG mice) and those co-expressing HLA-DR4 and HLA-A2 molecules (DRAGA mice) did not differ in their ability to develop human T and B cells, to reconstitute cytokine-secreting CD4 T and CD8 T cells, or to undergo immunoglobulin class switching. In contrast, NRG mice expressing only HLA-A2 molecules (A2 mice) reconstituted lower numbers of CD4 T cells but similar numbers of CD8 T cells. The T cells from A2 mice were deficient at secreting cytokines, and their B cells could not undergo immunoglobulin class switching. The inability of A2 mice to undergo immunoglobulin class switching is due to deficient CD4 helper T cell function. Upon immunization, the frequency and cytotoxicity of antigen-specific CD8 T cells in DRAGA mice was significantly higher than in A2 mice. The results indicated a multifactorial effect of the HLA-DR4 transgene on development and function of human CD4 T cells, antigen-specific human CD8 T cells, and immunoglobulin class switching. C1 [Majji, Sai; Wijayalath, Wathsala; Shashikumar, Soumya; Villasante, Eileen; Casares, Sofia] Walter Reed Army Inst Res, Naval Med Res Ctr, US Mil Malaria Vaccine Program, Silver Spring, MD USA. [Pow-Sang, Luis; Brumeanu, Teodor D.; Casares, Sofia] Uniformed Serv Univ Hlth Sci, Dept Med, Room A3060, Bethesda, MD 20814 USA. RP Casares, S (reprint author), Walter Reed Army Inst Res, Naval Med Res Ctr, US Mil Malaria Vaccine Program, Silver Spring, MD USA.; Casares, S (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med, Room A3060, Bethesda, MD 20814 USA. EM sofia.a.casares.civ@mail.mil FU Military Infectious Diseases Research Program (MIDRP) [A1210] FX This work was supported by work unit number A1210 with funding from the Military Infectious Diseases Research Program (MIDRP) to S.C., S.C., T.D.B. and E.F.V. are US Government employees. The work of these individuals was prepared as part of official government duties. Title 17 U.S.C. 105 provides that 'Copyright protection under this title is not available for any work of the United States Government.' Title 17 U.S.C. 101 defines a U.S. Government work as a work prepared by a military service member or employee of the U.S. Government as part of that person's official duties. The views expressed are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, nor the U.S. Government. NR 33 TC 0 Z9 0 U1 1 U2 1 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD JUN 21 PY 2016 VL 6 AR 28093 DI 10.1038/srep28093 PG 13 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DP1IT UT WOS:000378244400001 PM 27323875 ER PT J AU Guo, WW Lv, HJ Sullivan, KP Gordon, WO Balboa, A Wagner, GW Musaev, DG Bacsa, J Hill, CL AF Guo, Weiwei Lv, Hongjin Sullivan, Kevin P. Gordon, Wesley O. Balboa, Alex Wagner, George W. Musaev, Djamaladdin G. Bacsa, John Hill, Craig L. TI Broad-Spectrum Liquid- and Gas-Phase Decontamination of Chemical Warfare Agents by One-Dimensional Heteropolyniobates SO ANGEWANDTE CHEMIE-INTERNATIONAL EDITION LA English DT Article DE catalysis; chemical warfare agents; decontamination; heteropolyniobates; hydrolysis ID METAL-ORGANIC FRAMEWORK; DIISOPROPYL FLUOROPHOSPHATE; CATALYZED-HYDROLYSIS; LINDQVIST ION; DEGRADATION; OXIDATION; WATER; PROTECTION; SIMULANTS; VX AB A wide range of chemical warfare agents and their simulants are catalytically decontaminated by a new one-dimensional polymeric polyniobate (P-PONb), K-12[Ti2O2] [GeNb12O40]center dot 19H(2)O (KGeNb) under mild conditions and in the dark. Uniquely, KGeNb facilitates hydrolysis of nerve agents Sarin (GB) and Soman (GD) (and their less reactive simulants, dimethyl methylphosphonate (DMMP)) as well as mustard (HD) in both liquid and gas phases at ambient temperature and in the absence of neutralizing bases or illumination. Three lines of evidence establish that KGeNb removes DMMP, and thus likely GB/GD, by general base catalysis: a) the k(H2O)/k(D2O) solvent isotope effect is 1.4; b) the rate law (hydrolysis at the same pH depends on the amount of P-PONb present); and c) hydroxide is far less active against the above simulants at the same pH than the P-PONbs themselves, a critical control experiment. C1 [Guo, Weiwei; Sullivan, Kevin P.; Musaev, Djamaladdin G.; Hill, Craig L.] Emory Univ, Dept Chem, Cherry L Emerson Ctr Sci Computat, 1515 Dickey Dr, Atlanta, GA 30322 USA. [Guo, Weiwei; Sullivan, Kevin P.; Bacsa, John; Hill, Craig L.] Emory Univ, Xray Crystallog Ctr, 1515 Dickey Dr, Atlanta, GA 30322 USA. [Gordon, Wesley O.; Balboa, Alex; Wagner, George W.] US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Hill, CL (reprint author), Emory Univ, Dept Chem, Cherry L Emerson Ctr Sci Computat, 1515 Dickey Dr, Atlanta, GA 30322 USA.; Hill, CL (reprint author), Emory Univ, Xray Crystallog Ctr, 1515 Dickey Dr, Atlanta, GA 30322 USA. EM chill@emory.edu FU ARO [W911NF-12-1-0136]; Defense Threat Reduction Agency [BB11PHM156, BA13PHM210] FX C.L.H. thanks the ARO (grant number W911NF-12-1-0136) for support of this work. W.O.G., A.B. and G.W.W. (Programs BB11PHM156 and BA13PHM210) gratefully acknowledge support by the Defense Threat Reduction Agency. We thank Bryan Schindler for help on the DRIFTS experiments. NR 56 TC 6 Z9 6 U1 29 U2 31 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 1433-7851 EI 1521-3773 J9 ANGEW CHEM INT EDIT JI Angew. Chem.-Int. Edit. PD JUN 20 PY 2016 VL 55 IS 26 BP 7403 EP 7407 DI 10.1002/anie.201601620 PG 5 WC Chemistry, Multidisciplinary SC Chemistry GA DV6WI UT WOS:000383077400013 PM 27061963 ER PT J AU Riordan, JK AF Riordan, Joan Katherine TI Preconception counseling after bariatric surgery SO NURSE PRACTITIONER LA English DT Article ID GASTRIC BYPASS-SURGERY AB Obesity has increased exponentially in the United States, affecting over 78 million individuals. As the rates of obesity increase, providers encounter more women with a history of bariatric surgery. Certain bariatric procedures can change how essential nutrients are absorbed. Preconception counseling assists in identifying potential deficiencies early. C1 [Riordan, Joan Katherine] US Army, Honolulu, HI USA. [Riordan, Joan Katherine] Vet Hlth Adm, Fayetteville, NC USA. RP Riordan, JK (reprint author), Vet Hlth Adm, Fayetteville, NC USA. NR 20 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0361-1817 EI 1538-8662 J9 NURSE PRACT JI Nurse Pract. PD JUN 19 PY 2016 VL 41 IS 6 BP 1 EP 6 DI 10.1097/01.NPR.0000483076.70837.85 PG 6 WC Nursing SC Nursing GA DQ7GN UT WOS:000379375000001 PM 27203454 ER PT J AU Onal, H Wang, YC Dissanayake, STM Westervelt, JD AF Oenal, Hayri Wang, Yicheng Dissanayake, Sahan T. M. Westervelt, James D. TI Optimal design of compact and functionally contiguous conservation management areas SO EUROPEAN JOURNAL OF OPERATIONAL RESEARCH LA English DT Article DE (D) OR in natural resources; Compactness; Landscape connectivity; Integer programming ID RESERVE SITE SELECTION; LANDSCAPE CONNECTIVITY; PROGRAMMING APPROACH; FRAGMENTED LANDSCAPES; LOCATION PROBLEM; NETWORK; MODEL; ALGORITHMS; MULTIPLE; EXAMPLE AB Compactness and landscape connectivity are essential properties for effective functioning of conservation reserves. In this article we introduce a linear integer programming model to determine optimal configuration of a conservation reserve with such properties. Connectivity can be defined either as structural (physical) connectivity or functional connectivity; the model developed here addresses both properties. We apply the model to identify the optimal conservation management areas for protection of Gopher Tortoise (GT) in a military installation, Ft. Benning, Georgia, which serves as a safe refuge for this 'at risk' species. The recent expansion in the military mission of the installation increases the pressure on scarce GT habitat areas, which requires moving some of the existent populations in those areas to suitably chosen new conservation management areas within the boundaries of the installation. Using the model, we find the most suitable and spatially coherent management areas outside the heavily used training areas. (C) 2015 Elsevier B.V. All rights reserved. C1 [Oenal, Hayri] Univ Illinois, Dept Agr & Consumer Econ, 1301 West Gregory Dr,305 Mumford Hall, Urbana, IL 61801 USA. [Wang, Yicheng] Qingdao Agr Univ, Coll Resources & Environm, 700 Changcheng Rd, Qingdao 266109, Peoples R China. [Dissanayake, Sahan T. M.] Colby Coll, Dept Econ, Diamond 347,5247 Mayflower Hill, Waterville, ME 04901 USA. [Westervelt, James D.] US Army Engineer Res & Dev Ctr, ERDC CERL, 2902 Newmark Dr, Champaign, IL 61822 USA. RP Onal, H (reprint author), Univ Illinois, Dept Agr & Consumer Econ, 1301 West Gregory Dr,305 Mumford Hall, Urbana, IL 61801 USA. EM h-onal@illinois.edu; qdwangyc@yahoo.com.cn; sdissan2@gmail.com; James.D.Westervelt@erdc.dren.mil OI Onal, Hayri/0000-0002-0307-1731; Dissanayake, Sahan/0000-0002-4342-5979 FU ERDC-CERL [W81EWF-7204-6330]; CREES [ILLU 05-0361]; National Natural Science Foundation of China [71202096] FX This research was partially supported by the ERDC-CERL Project no. W81EWF-7204-6330, CREES Project no. ILLU 05-0361, and National Natural Science Foundation of China (71202096). NR 80 TC 1 Z9 1 U1 4 U2 21 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0377-2217 EI 1872-6860 J9 EUR J OPER RES JI Eur. J. Oper. Res. PD JUN 16 PY 2016 VL 251 IS 3 BP 957 EP 968 DI 10.1016/j.ejor.2015.12.005 PG 12 WC Management; Operations Research & Management Science SC Business & Economics; Operations Research & Management Science GA DF9AG UT WOS:000371652000020 ER PT J AU Pflipsen, M Massaquoi, M Wolf, S AF Pflipsen, Matthew Massaquoi, Mariama Wolf, Suzanne TI Evaluation of the Painful Eye SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID RED EYE; OPTIC-NEURITIS; HERPES-SIMPLEX; PRIMARY-CARE; KERATITIS; MANAGEMENT; DISORDERS; ABRASIONS AB Eye problems constitute 2% to 3% of all primary care and emergency department visits. Common eye conditions that can cause eye pain are conjunctivitis, corneal abrasion, and hordeolum, and some of the most serious eye conditions include acute angle-closure glaucoma, orbital cellulitis, and herpetic keratitis. The history should focus on vision changes, foreign body sensation, photophobia, and associated symptoms, such as headache. The physical examination includes an assessment of visual acuity and systematic evaluation of the conjunctiva, eyelids, sclera, cornea, pupil, anterior chamber, and anterior uvea. Further examination with fluorescein staining and tonometry is often necessary. Because eye pain can be the first sign of an ophthalmologic emergency, the physician should determine if referral is warranted. Specific conditions that require ophthalmology consultation include acute angle-closure glaucoma, optic neuritis, orbital cellulitis, scleritis, anterior uveitis, and infectious keratitis. Copyright (C) 2016 American Academy of Family Physicians. C1 [Pflipsen, Matthew; Massaquoi, Mariama; Wolf, Suzanne] Tripler Army Med Ctr, Dept Family Med, Honolulu, HI 96859 USA. [Pflipsen, Matthew] Uniformed Serv Univ Hlth Sci, Dept Family Med, Bethesda, MD 20814 USA. RP Pflipsen, M (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM matthew.c.pflipsen.mil@mail.mil NR 41 TC 0 Z9 0 U1 7 U2 7 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X EI 1532-0650 J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD JUN 15 PY 2016 VL 93 IS 12 BP 991 EP 998 PG 8 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA DO2TU UT WOS:000377633800004 PM 27304768 ER PT J AU Das, D Power, B Martin, JP Polcawich, RG Chasiotis, I AF Das, Debashish Power, Brian Martin, Joel P. Polcawich, Ronald G. Chasiotis, Ioannis TI Role of oxide seed layer in plastic response of epitaxially grown textured metal films SO ACTA MATERIALIA LA English DT Article DE Platinum; Heteroepitaxy; Rutile; Thompson model; Elastoplastic response; Bilayer ID THIN-FILMS; DEFORMATION-BEHAVIOR; THERMAL STRAIN; FLOW-STRESS; GRAIN-SIZE; AL FILMS; THICKNESS; BOUNDARY; CU; MECHANISMS AB The elastic/plastic mechanical behavior of freestanding polycrystalline {111}-textured Pt films with thicknesses 50-1000 nm and different combinations of grain size and film thickness, grown epitaxially on a 35-50 nm thick polycrystalline (100)-TiO2 (rutile) seed layer, was studied at uniaxial tension strain rates 10(-6) - 10 s(-1). The mismatch strain between the (111)-Pt films and the underlying (100)-TiO2 seed layer gives rise to an interfacial dislocation network, which, in turn, determines the initiation of plastic deformation in Pt. Experiments showed that the flow stress increases, while the plastic strain accumulation at failure decreases with decreasing Pt film thickness. A modified Thompson model that accounted for the combined effect of film thickness and grain size provided good predictions for the elastic limit of Pt films. However, the yield stress was underestimated by the same model; a Taylor strain hardening model was superimposed to the modified Thompson model to account for additional hardening as a result of dislocation interactions during plastic deformation, which provided good predictions for the evolution of flow stress with plastic strain. (C) 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Das, Debashish; Chasiotis, Ioannis] Univ Illinois, Dept Aerosp Engn, Urbana, IL 61801 USA. [Power, Brian; Martin, Joel P.] US Army Res Lab, Adelphi, MD 20783 USA. [Polcawich, Ronald G.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Chasiotis, I (reprint author), Univ Illinois, Dept Aerosp Engn, Urbana, IL 61801 USA. EM debritum@gmail.com; brian.k.power2.civ@mail.mil; joel.l.martin.civ@mail.mil; ronald.g.polcawich.civ@mail.mil; chasioti@illinois.edu FU ARO [W911NF-12-1-0204] FX The authors acknowledge the support by ARO Grant #W911NF-12-1-0204 with Drs. Larry Russell and Asher Rubinstein as the program managers. Further, FIB, SEM and X-Ray studies were carried out at the Frederick Seitz Materials Research Laboratory Central Research Facilities, University of Illinois. NR 50 TC 1 Z9 1 U1 5 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6454 EI 1873-2453 J9 ACTA MATER JI Acta Mater. PD JUN 15 PY 2016 VL 112 BP 390 EP 402 DI 10.1016/j.actamat.2016.04.025 PG 13 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA DN8KA UT WOS:000377326400036 ER PT J AU O'Connell, RJ Excler, JL Polonis, VR Ratto-Kim, S Cox, J Jagodzinski, LL Liu, M Wieczorek, L McNeil, JG El-Habib, R Michael, NL Gilliam, BL Paris, R VanCott, TC Tomaras, GD Birx, DL Robb, ML Kim, JH AF O'Connell, Robert J. Excler, Jean-Louis Polonis, Victoria R. Ratto-Kim, Silvia Cox, Josephine Jagodzinski, Linda L. Liu, Michelle Wieczorek, Lindsay McNeil, John G. El-Habib, Raphaelle Michael, Nelson L. Gilliam, Bruce L. Paris, Robert VanCott, Thomas C. Tomaras, Georgia D. Birx, Deborah L. Robb, Merlin L. Kim, Jerome H. TI Safety and Immunogenicity of a Randomized Phase 1 Prime-Boost Trial With ALVAC-HIV (vCP205) and Oligomeric Glycoprotein 160 From HIV-1 Strains MN and LAI-2 Adjuvanted in Alum or Polyphosphazene SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE HIV; vaccine; prime-boost; neutralizing antibody; adjuvant; polyphosphazene ID IMMUNODEFICIENCY-VIRUS TYPE-1; T-CELL RESPONSES; NEUTRALIZING ANTIBODY-RESPONSE; EFFICACY TRIAL; SUBTYPE-E; LYMPHOCYTE RESPONSES; PREVENTIVE VACCINE; CANDIDATE VACCINE; MONOMERIC GP120; THAI ADULTS AB Background. Prime-boost regimens comprising ALVAC-HIV (prime) and human immunodeficiency virus type 1 (HIV) Env (boost) induce HIV-specific neutralizing antibody and cell-mediated immune responses, but the impact of boost schedule and adjuvant requires further definition. Methods. A phase 1 trial was conducted. In part A (open label), 19 volunteers received oligomeric glycoprotein 160 from HIV strains MN and LAI-2 (ogp160 MN/LAI-2) with dose escalation (25, 50, 100 mu g) and either polyphosphazene (pP) or alum adjuvant. In part B, 72 volunteers received either placebo (n=12) or recombinant canarypox virus expressing HIV antigens (ALVAC-HIV [vCP205]) with different doses and schedules of ogp160 MN/LAI-2 in pP or alum (n = 60). Results. The vaccines were safe and well tolerated, with no vaccine-related serious adverse events. Anti-gp70 V1V2 antibody responses were detected in 17 of 19 part A volunteers (89%) and 10%-100% of part B volunteers. Use of a peripheral blood mononuclear cell-based assay revealed that US-1 primary isolate neutralization was induced in 2 of 19 recipients of ogp160 protein alone (10.5%) and 5 of 49 prime-boost volunteers (10.2%). Among ogp160 recipients, those who received pP were more likely than those who received alum to have serum that neutralized tier 2 viruses (12% vs 0%; P = .015). Conclusions. Administration of ogp160 with pP induces primary isolate tier 2 neutralizing antibody responses in a small percentage of volunteers, demonstrating proof of concept and underscoring the importance of further optimization of prime-boost strategies for HIV infection prevention. C1 [O'Connell, Robert J.] Armed Forces Inst Med Sci, US Army Med Directorate, Dept Retrovirol, Bangkok, Thailand. [Excler, Jean-Louis; Liu, Michelle; Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Excler, Jean-Louis; Polonis, Victoria R.; Ratto-Kim, Silvia; Jagodzinski, Linda L.; Liu, Michelle; Wieczorek, Lindsay; Michael, Nelson L.; Robb, Merlin L.; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Paris, Robert] Walter Reed Army Inst Res, US Mil Malaria Res Program, Silver Spring, MD USA. [Gilliam, Bruce L.] Univ Maryland, Sch Med, Inst Human Virol, Baltimore, MD 21201 USA. [VanCott, Thomas C.] Adv Biosci Labs, Rockville, MD USA. [Cox, Josephine] Int AIDS Vaccine Initiat, New York, NY USA. [Tomaras, Georgia D.] Duke Univ, Sch Med, Durham, NC USA. [Birx, Deborah L.] Off Global AIDS Coordinator, Washington, DC USA. [El-Habib, Raphaelle] Sanofi Pasteur, Marcy Letoile, France. [Kim, Jerome H.] Int Vaccine Inst, Seoul, South Korea. RP O'Connell, RJ (reprint author), Armed Forces Inst Med Sci, US Army Med Directorate, Dept Retrovirol, Bangkok, Thailand. EM robert.oconnell.mil@afrims.org FU Military Infectious Diseases Research Program, US Army Medical Research and Materiel Command [DAMD17-98-2-7007]; Henry M. Jackson Foundation for the Advancement of Military Medicine; National Institute of Allergy and Infectious Diseases, National Institutes of Health, through the Duke University Center for AIDS Research [AI064518] FX This work was supported by the Military Infectious Diseases Research Program, US Army Medical Research and Materiel Command, through a cooperative agreement (DAMD17-98-2-7007) with the Henry M. Jackson Foundation for the Advancement of Military Medicine; and the National Institute of Allergy and Infectious Diseases, National Institutes of Health, through the Duke University Center for AIDS Research (grant AI064518). NR 48 TC 1 Z9 1 U1 3 U2 5 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD JUN 15 PY 2016 VL 213 IS 12 BP 1946 EP 1954 DI 10.1093/infdis/jiw059 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA DO0BL UT WOS:000377444300015 PM 26908741 ER PT J AU Li, JT Cushing, SK Chu, D Zheng, P Bright, J Castle, C Manivannan, A Wu, NQ AF Li, Jiangtian Cushing, Scott K. Chu, Deryn Zheng, Peng Bright, Joeseph Castle, Conner Manivannan, Ayyakkannu Wu, Nianqiang TI Distinguishing surface effects of gold nanoparticles from plasmonic effect on photoelectrochemical water splitting by hematite SO JOURNAL OF MATERIALS RESEARCH LA English DT Article DE energy generation; nanostructure; photochemical ID PHOTOCATALYTIC ACTIVITY; METAL NANOPARTICLES; BIVO4 PHOTOANODES; ENERGY-TRANSFER; NANOROD ARRAY; SOLAR; SEMICONDUCTOR; CELLS; ENHANCEMENT; GENERATION AB Gold nanoparticles have been deposited on the surface of hematite nanorod array photoanode to improve the photoelectrochemical water splitting performance. The Au nanoparticles induce the Fermi level equilibration, the surface catalysis, and the plasmonic enhancement effects in the Au/hematite photoanode. The Fermi level equilibration effect promotes the extraction of photo-generated charge carriers, suppressing the charge recombination. Surface catalysis effect reduces the overpotential for photoelectrochemical water oxidation. In the Au/hematite sample, the Fermi level equilibration and the surface catalysis effect make major contribution to photocurrent enhancement while the plasmonic effect makes a little contribution. In addition, the Au@SiO2 particle has been immobilized on hematite nanorod array surface that has been passivated. In the Au@SiO2/hematite sample, the photocurrent enhancement originating from plasmonic effects is negligible. Both the Femi level equilibration and the surface catalysis effects were excluded due to the isolated Au and hematite while surface passivation is mainly responsible for the photocurrent enhancement. C1 [Li, Jiangtian; Cushing, Scott K.; Zheng, Peng; Bright, Joeseph; Castle, Conner; Wu, Nianqiang] W Virginia Univ, Dept Mech & Aerosp Engn, Morgantown, WV 26506 USA. [Cushing, Scott K.] W Virginia Univ, Dept Phys & Astron, Morgantown, WV 26506 USA. [Chu, Deryn] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Manivannan, Ayyakkannu] US DOE, Natl Energy Technol Lab, Morgantown, WV 26507 USA. RP Wu, NQ (reprint author), W Virginia Univ, Dept Mech & Aerosp Engn, Morgantown, WV 26506 USA. EM nick.wu@mail.wvu.edu RI Wu, Nianqiang/B-9798-2015; OI Wu, Nianqiang/0000-0002-8888-2444; Bright, Joeseph/0000-0002-9017-0809; Zheng, Peng/0000-0001-5907-8505 FU US Army Research Laboratory [W911NF-14-2-0116]; National Science Foundation [CBET-1233795]; NSF Graduate Research Fellowship Grants [1102689] FX This work was financially supported by the US Army Research Laboratory (W911NF-14-2-0116) and National Science Foundation (CBET-1233795). S.K.C. and J.B. were grateful to the NSF Graduate Research Fellowship Grants (1102689). The use of WVU shared facility is acknowledged. NR 31 TC 1 Z9 1 U1 14 U2 24 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0884-2914 EI 2044-5326 J9 J MATER RES JI J. Mater. Res. PD JUN 14 PY 2016 VL 31 IS 11 BP 1608 EP 1615 DI 10.1557/jmr.2016.102 PG 8 WC Materials Science, Multidisciplinary SC Materials Science GA DQ3VR UT WOS:000379132200009 ER PT J AU Blagborough, AM Musiychuk, K Bi, H Jones, RM Chichester, JA Streatfield, S Sala, KA Zakutansky, SE Upton, LM Sinden, RE Brian, I Biswas, S Sattabonkot, J Yusibov, V AF Blagborough, A. M. Musiychuk, K. Bi, H. Jones, R. M. Chichester, J. A. Streatfield, S. Sala, K. A. Zakutansky, S. E. Upton, L. M. Sinden, R. E. Brian, I. Biswas, S. Sattabonkot, J. Yusibov, V. TI Transmission blocking potency and immunogenicity of a plant-produced Pvs25-based subunit vaccine against Plasmodium vivax SO VACCINE LA English DT Article DE Transmission blocking vaccine; Malaria; Plant-produced antigen; Plasmodium; Pvs25; Subunit vaccine ID MEROZOITE SURFACE PROTEIN-1; PROTECTS FERRETS; HUMAN MALARIA; SEXUAL STAGE; FALCIPARUM; ANTIBODIES; CANDIDATE; INFLUENZA; VECTORS; PVS25 AB Malaria transmission blocking (TB) vaccines (TBVs) directed against proteins expressed on the sexual stages of Plasmodium parasites are a potentially effective means to reduce transmission. Antibodies induced by TBVs block parasite development in the mosquito, and thus inhibit transmission to further human hosts. The ookinete surface protein P25 is a primary target for TBV development. Recently, transient expression in plants using hybrid viral vectors has demonstrated potential as a strategy for cost-effective and scalable production of recombinant vaccines. Using a plant virus-based expression system, we produced recombinant P25 protein of Plasmodium vivax (Pvs25) in Nicotiana benthamiana fused to a modified lichenase carrier protein. This candidate vaccine, Pvs25-FhCMB, was purified, characterized and evaluated for immunogenicity and efficacy using multiple adjuvants in a transgenic rodent model. An in vivo TB effect of up to a 65% reduction in intensity and 54% reduction in prevalence was observed using Abisco-100 adjuvant. The ability of this immunogen to induce a TB response was additionally combined with heterologous prime-boost vaccination with viral vectors expressing Pvs25. Significant blockade was observed when combining both platforms, achieving a 74% and 68% reduction in intensity and prevalence, respectively. This observation was confirmed by direct membrane feeding on field P. vivax samples, resulting in reductions in intensity/prevalence of 85.3% and 25.5%. These data demonstrate the potential of this vaccine candidate and support the feasibility of expressing Plasmodium antigens in a plant-based system for the production of TBVs, while demonstrating the potential advantages of combining multiple vaccine delivery systems to maximize efficacy. (C) 2016 The Author(s). Published by Elsevier Ltd. C1 [Blagborough, A. M.; Sala, K. A.; Zakutansky, S. E.; Upton, L. M.] Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, Sir Alexander Fleming Bldg,Imperial Coll Rd, London SW7 2AZ, England. [Musiychuk, K.; Bi, H.; Jones, R. M.; Chichester, J. A.; Streatfield, S.; Yusibov, V.] Fraunhofer USA, Ctr Mol Biotechnol, Newark, DE USA. [Sinden, R. E.; Brian, I.; Biswas, S.] Univ Oxford, Jenner Inst, Roosevelt Rd, Oxford OX9 2PP, England. [Sattabonkot, J.] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. RP Blagborough, AM (reprint author), Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, Sir Alexander Fleming Bldg,Imperial Coll Rd, London SW7 2AZ, England. EM andrew.blagborough@imperial.ac.uk OI Taylor, Iona/0000-0002-2287-9488 FU Bill and Melinda Gates Foundation, WA, USA; MVI-PATH; MMV; MRC [MR/N00227X/1] FX This work was funded by a grant from the Bill and Melinda Gates Foundation, WA, USA. A.M.B. thanks MVI-PATH, MMV, and the MRC (award number MR/N00227X/1) funding. The funders had no role in study design, data collection and interpretation, of the decision to submit the work for publication. We gratefully acknowledge Mark Tunnicliff for mosquito production, Dr. Joey Norikane for overseeing plant biomass generation and Dr. Natasha Kushnir for editorial assistance. NR 45 TC 2 Z9 2 U1 2 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD JUN 14 PY 2016 VL 34 IS 28 BP 3252 EP 3259 DI 10.1016/j.vaccine.2016.05.007 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA DP7EX UT WOS:000378663100008 PM 27177945 ER PT J AU Guha, S Towsley, D Nain, P Capar, C Swami, A Basu, P AF Guha, Saikat Towsley, Donald Nain, Philippe Capar, Cagatay Swami, Ananthram Basu, Prithwish TI Spanning connectivity in a multilayer network and its relationship to site-bond percolation SO PHYSICAL REVIEW E LA English DT Article ID SMALL-WORLD NETWORKS; SCIENTIFIC COLLABORATION; THRESHOLDS; ALGORITHM; GRAPHS AB We analyze the connectivity of an M-layer network over a common set of nodes that are active only in a fraction of the layers. Each layer is assumed to be a subgraph (of an underlying connectivity graph G) induced by each node being active in any given layer with probability q. The M-layer network is formed by aggregating the edges over all M layers. We show that when q exceeds a threshold q(c) (M), a giant connected component appears in theM-layer network-thereby enabling far-away users to connect using "bridge" nodes that are active in multiple network layers-even though the individual layers may only have small disconnected islands of connectivity. We show that q(c) (M) less than or similar to root-ln(1 - pc)/root M, where p(c) is the bond percolation threshold of G, and q(c) (1) equivalent to q(c) is its site-percolation threshold. We find q(c) (M) exactly for when G is a large random network with an arbitrary node-degree distribution. We find q(c) (M) numerically for various regular lattices and find an exact lower bound for the kagome lattice. Finally, we find an intriguingly close connection between this multilayer percolation model and the well-studied problem of site-bond percolation in the sense that both models provide a smooth transition between the traditional site-and bond-percolation models. Using this connection, we translate known analytical approximations of the site-bond critical region, which are functions only of p(c) and q(c) of the respective lattice, to excellent general approximations of the multilayer connectivity threshold q(c) (M). C1 [Guha, Saikat; Basu, Prithwish] Raytheon BBN Technol, Cambridge, MA 02138 USA. [Towsley, Donald] Univ Massachusetts, Amherst, MA 01003 USA. [Nain, Philippe] Inria, F-06902 Sophia Antipolis, France. [Capar, Cagatay] Ericsson Res, San Jose, CA 95134 USA. [Swami, Ananthram] US Army, Res Lab, Adelphi, MD 20783 USA. RP Guha, S (reprint author), Raytheon BBN Technol, Cambridge, MA 02138 USA. FU U.S. Army Research Laboratory (ARL); U.K. Ministry of Defense (MoD); U.S. ARL [W911NF-06-3-0002.1]; UK MoD NIS-ITA [W911NF-06-3-0002.1]; US ARL NS-CTA [W911NF-09-2-0053]; UMASS Amherst NSF [CNS-1018464] FX S.G. thanks Hari Krovi for useful discussions and Robert Ziff for providing useful comments on an early draft and for pointing out prior results on site-percolation thresholds for the stacked Kagome lattice. P.N. thanks Alain Jean-Marie for helping prove the uniqueness of the root for fSB(q) = 0. The authors thank an anonymous referee for noting a small discrepancy in Fig. 6, which helped identify a numerical issue in our Newman-Ziff simulations. This research was sponsored by the U.S. Army Research Laboratory (ARL) and the U.K. Ministry of Defense (MoD) and was accomplished under Agreements No. W911NF-06-3-0002.1 (U.S. ARL and UK MoD NIS-ITA) and No. W911NF-09-2-0053 (US ARL NS-CTA). C.C. acknowledges useful discussions with Dennis Goeckel and support from the UMASS Amherst NSF Grant No. CNS-1018464. This document does not contain technology or technical data controlled under either the U.S. International Traffic in Arms Regulations or the U.S. Export Administration Regulations. NR 37 TC 1 Z9 1 U1 2 U2 2 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2470-0045 EI 2470-0053 J9 PHYS REV E JI Phys. Rev. E PD JUN 14 PY 2016 VL 93 IS 6 AR 062310 DI 10.1103/PhysRevE.93.062310 PG 17 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA DO5FF UT WOS:000377808300008 PM 27415283 ER PT J AU Suo, LM Borodin, O Sun, W Fan, XL Yang, CY Wang, F Gao, T Ma, ZH Schroeder, M von Cresce, A Russell, SM Armand, M Angell, A Xu, K Wang, CS AF Suo, Liumin Borodin, Oleg Sun, Wei Fan, Xiulin Yang, Chongyin Wang, Fei Gao, Tao Ma, Zhaohui Schroeder, Marshall von Cresce, Arthur Russell, Selena M. Armand, Michel Angell, Austen Xu, Kang Wang, Chunsheng TI Advanced High-Voltage Aqueous Lithium-Ion Battery Enabled by "Water-in-Bisalt" Electrolyte SO ANGEWANDTE CHEMIE-INTERNATIONAL EDITION LA English DT Article DE anatase TiO2; aqueous batteries; electrolyte; lithium-ion batteries; water-in-bisalt ID CYCLING STABILITY; SALT ELECTROLYTE; RECHARGEABLE LI; TIO2 AB A new super-concentrated aqueous electrolyte is proposed by introducing a second lithium salt. The resultant ultra-high concentration of 28 m led to more effective formation of a protective interphase on the anode along with further suppression of water activities at both anode and cathode surfaces. The improved electrochemical stability allows the use of TiO2 as the anode material, and a 2.5 Vaqueous Li-ion cell based on LiMn2O4 and carbon-coated TiO2 delivered the unprecedented energy density of 100 Wh kg(-1) for rechargeable aqueous Li-ion cells, along with excellent cycling stability and high coulombic efficiency. It has been demonstrated that the introduction of a second salts into the "water-in-salt" electrolyte further pushed the energy densities of aqueous Li-ion cells closer to those of the state-of-the-art Li-ion batteries. C1 [Suo, Liumin; Sun, Wei; Fan, Xiulin; Yang, Chongyin; Wang, Fei; Gao, Tao; Ma, Zhaohui; Wang, Chunsheng] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20740 USA. [Borodin, Oleg; Schroeder, Marshall; von Cresce, Arthur; Russell, Selena M.; Xu, Kang] US Army Res Lab, Electrochem Branch, Sensor & Electron Devices Directorate, Power & Energy Div, Adelphi, MD 20783 USA. [Armand, Michel] IC Energigune, Alava Technol Pk, Minano, Alava, Spain. [Angell, Austen] Arizona State Univ, Sch Mol Sci, Tempe, AZ 85287 USA. RP Wang, CS (reprint author), Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20740 USA.; Xu, K (reprint author), US Army Res Lab, Electrochem Branch, Sensor & Electron Devices Directorate, Power & Energy Div, Adelphi, MD 20783 USA. EM conrad.k.xu.civ@mail.mil; cswang@umd.edu RI Wang, Chunsheng/H-5767-2011 OI Wang, Chunsheng/0000-0002-8626-6381 FU DOE ARPA-E [DEAR0000389]; Maryland Nano Center; Nisp Lab; SAC Lab FX C.W. and K.X. gratefully acknowledge funding from DOE ARPA-E (DEAR0000389). We also thank the support of the Maryland Nano Center and its Nisp Lab and SAC Lab, and Dr. Karen Gaskell for their technical support and helpful discussion. Modeling efforts were supported by ARL Enterprise for Multiscale Research of Materials. NR 22 TC 7 Z9 7 U1 93 U2 116 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 1433-7851 EI 1521-3773 J9 ANGEW CHEM INT EDIT JI Angew. Chem.-Int. Edit. PD JUN 13 PY 2016 VL 55 IS 25 BP 7136 EP 7141 DI 10.1002/anie.201602397 PG 6 WC Chemistry, Multidisciplinary SC Chemistry GA DV2ZK UT WOS:000382790600018 PM 27120336 ER PT J AU Muraviev, A Gutin, A Rupper, G Rudin, S Shen, XH Yamaguchi, M Aizin, G Shur, M AF Muraviev, Andrey Gutin, Alexey Rupper, Greg Rudin, Sergey Shen, Xiaohan Yamaguchi, Masashi Aizin, Gregory Shur, Michael TI New optical gating technique for detection of electric field waveforms with subpicosecond resolution SO OPTICS EXPRESS LA English DT Article ID TERAHERTZ RADIATION; EFFECT TRANSISTORS; PLASMA-WAVES; LASER; COMMUNICATION; GENERATION; FLUID; BEAMS AB The new optical gating technique uses a femtosecond optical laser pulses for the photoconductive detection of short pulses of terahertz (THz) radiation. This technique reproduces the shape of the THz pulse and after pulse plasmonic response of the two-dimensional electron gas in a short channel high electron mobility transistor (HEMT). The results are in excellent agreement with the electro-optic effect measurements and with the simulation results obtained in the frame of a two-dimensional hydrodynamic model. The femtosecond optical laser pulse time is delayed with respect to the THz pulse and generates a large concentration of the electron-hole pairs in the AlGaAs/InGaAs HEMT. This drastically increases the channel conductivity on the femtosecond scale and effectively shorts the device quenching the transistor response. The achieved time resolution is better than 250 femtoseconds and could be improved using shorter femtosecond laser pulses. The spatial resolution of this technique is on the order of tens of nanometers or even smaller. It could be applied for studying the electron transport in a variety of electronic devices ranging from silicon MOSFETs to heterostructure bipolar transistors. (C)2016 Optical Society of America C1 [Muraviev, Andrey; Gutin, Alexey; Shen, Xiaohan; Yamaguchi, Masashi; Shur, Michael] Rensselaer Polytech Inst, Troy, NY 12180 USA. [Rupper, Greg; Rudin, Sergey] US Army Res Lab, Adelphi, MD USA. [Aizin, Gregory] CUNY, Kingsborough Coll, Brooklyn, NY 11210 USA. RP Shur, M (reprint author), Rensselaer Polytech Inst, Troy, NY 12180 USA. EM shurm@rpi.edu FU U.S. Army Research Laboratory through the Collaborative Research Alliance (CRA) for Multi-Scale Modeling of Electronic Materials (MSME) FX The work at RPI was supported in part by the U.S. Army Research Laboratory through the Collaborative Research Alliance (CRA) for Multi-Scale Modeling of Electronic Materials (MSME). NR 32 TC 1 Z9 1 U1 6 U2 8 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD JUN 13 PY 2016 VL 24 IS 12 BP 12730 EP 12739 DI 10.1364/OE.24.012730 PG 10 WC Optics SC Optics GA DP2DN UT WOS:000378298400027 PM 27410292 ER PT J AU Tong, JL Maruta, J Heaton, KJ Maule, AL Rajashekar, U Spielman, LA Ghajar, J AF Tong, Jianliang Maruta, Jun Heaton, Kristin J. Maule, Alexis L. Rajashekar, Umesh Spielman, Lisa A. Ghajar, Jamshid TI Degradation of Binocular Coordination during Sleep Deprivation SO FRONTIERS IN NEUROLOGY LA English DT Article DE alertness; attention; fatigue; ocular pursuit; screening ID SACCADIC EYE-MOVEMENTS; SMOOTH-PURSUIT; SYNCHRONIZATION; ATTENTION; NIGHT AB To aid a clear and unified visual perception while tracking a moving target, both eyes must be coordinated, so the image of the target falls on approximately corresponding areas of the fovea of each eye. The movements of the two eyes are decoupled during sleep, suggesting a role of arousal in regulating binocular coordination. While the absence of visual input during sleep may also contribute to binocular decoupling, sleepiness is a state of reduced arousal that still allows for visual input, providing a context within which the role of arousal in binocular coordination can be studied. We examined the effects of sleep deprivation on binocular coordination using a test paradigm that we previously showed to be sensitive to sleep deprivation. We quantified binocular coordination with the SD of the distance between left and right gaze positions on the screen. We also quantified the stability of conjugate gaze on the target, i.e., gaze target synchronization, with the SD of the distance between the binocular average gaze and the target. Sleep deprivation degraded the stability of both binocular coordination and gaze target synchronization, but between these two forms of gaze control the horizontal and vertical components were affected differently, suggesting that disconjugate and conjugate eye movements are under different regulation of attentional arousal. The prominent association found between sleep deprivation and degradation of binocular coordination in the horizontal direction may be used for a fit-for-duty assessment. C1 [Tong, Jianliang; Maruta, Jun; Rajashekar, Umesh; Spielman, Lisa A.; Ghajar, Jamshid] Brain Trauma Fdn, New York, NY USA. [Heaton, Kristin J.; Maule, Alexis L.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. [Heaton, Kristin J.; Maule, Alexis L.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA. [Ghajar, Jamshid] Stanford Univ, Sch Med, Dept Neurosurg, Stanford, CA 94305 USA. RP Maruta, J (reprint author), Brain Trauma Fdn, New York, NY USA. EM jmaruta@braintrauma.org OI Maruta, Jun/0000-0002-5054-6605 FU Congressionally Directed Medical Research Program (CDMRP) through an Advanced Technology Award [W81XWH-08-2-0646]; US Army Medical Research and Materiel Command award [W81XWH-08-1-002] FX This work was supported by Congressionally Directed Medical Research Program (CDMRP) through an Advanced Technology Award (W81XWH-08-2-0646) to JG and by a US Army Medical Research and Materiel Command award (W81XWH-08-1-002; Project PI: SP Proctor, Site PI: KH) to the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Army or the Department of Defense. NR 36 TC 0 Z9 0 U1 5 U2 5 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1664-2295 J9 FRONT NEUROL JI Front. Neurol. PD JUN 13 PY 2016 VL 7 AR 90 DI 10.3389/fneur.2016.00090 PG 7 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA DO2BT UT WOS:000377585200002 PM 27379009 ER PT J AU Ries, AJ Touryan, J Ahrens, B Connolly, P AF Ries, Anthony J. Touryan, Jon Ahrens, Barry Connolly, Patrick TI The Impact of Task Demands on Fixation-Related Brain Potentials during Guided Search SO PLOS ONE LA English DT Article ID LATENCY DIFFERENCES; EVOKED-POTENTIALS; LAMBDA-RESPONSES; VISUAL-SEARCH; EYE-MOVEMENT; EEG; COMPONENT; ONSET; ATTENTION; ERPS AB Recording synchronous data from EEG and eye-tracking provides a unique methodological approach for measuring the sensory and cognitive processes of overt visual search. Using this approach we obtained fixation related potentials (FRPs) during a guided visual search task specifically focusing on the lambda and P3 components. An outstanding question is whether the lambda and P3 FRP components are influenced by concurrent task demands. We addressed this question by obtaining simultaneous eye-movement and electroencephalographic (EEG) measures during a guided visual search task while parametrically modulating working memory load using an auditory N-back task. Participants performed the guided search task alone, while ignoring binaurally presented digits, or while using the auditory information in a 0, 1, or 2-back task. The results showed increased reaction time and decreased accuracy in both the visual search and N-back tasks as a function of auditory load. Moreover, high auditory task demands increased the P3 but not the lambda latency while the amplitude of both lambda and P3 was reduced during high auditory task demands. The results show that both early and late stages of visual processing indexed by FRPs are significantly affected by concurrent task demands imposed by auditory working memory. C1 [Ries, Anthony J.; Touryan, Jon] US Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA. [Ahrens, Barry] Nova SE Univ, Coll Engn & Comp, Ft Lauderdale, FL 33314 USA. [Connolly, Patrick] Teledyne Sci Co, Durham, NC USA. RP Ries, AJ (reprint author), US Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA. EM anthony.j.ries2.civ@mail.mil FU U.S. Army Prime [W911NF-09-D-0001] FX U.S. Army Prime Contract No. W911NF-09-D-0001. The funder provided support in the form of salaries for authors [BA and PC], but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the 'author contributions' section.; The authors would like to thank Steve Simons and David Kowachek for their valuable feedback on the manuscript. This research was supported by U.S. Army Prime Contract No. W911NF-09-D-0001. NR 55 TC 0 Z9 0 U1 2 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUN 10 PY 2016 VL 11 IS 6 AR e0157260 DI 10.1371/journal.pone.0157260 PG 17 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA DO1UG UT WOS:000377564000051 PM 27286248 ER EF