FN Thomson Reuters Web of Science™ VR 1.0 PT J AU RAGNO, JR SZKUTNIK, AJ AF RAGNO, JR SZKUTNIK, AJ TI EVALUATION OF 0.12-PERCENT CHLORHEXIDINE RINSE ON THE PREVENTION OF ALVEOLAR OSTEITIS SO ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS LA English DT Article ID SURGERY AB A double-blind study evaluated the ability of 0.12% chlorhexidine rinse to decrease the incidence of localized alveolar osteitis after the removal of mandibular third molar teeth. One hundred sixty extraction sites in 80 patients were evaluated. A statistically significant decrease in the incidence of dry socket was seen in patients using the chlorhexidine rinse with no significant adverse reactions. Thus a 0.12% chlorhexidine rinse is shown to be an effective means of decreasing alveolar osteitis that may follow removal of third molar teeth. C1 WALTER REED ARMY MED CTR,BULK MFG & INVEST PROTOCOLS,WASHINGTON,DC 20307. NR 17 TC 33 Z9 35 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 1079-2104 J9 ORAL SURG ORAL MED O JI Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. PD NOV PY 1991 VL 72 IS 5 BP 524 EP 526 DI 10.1016/0030-4220(91)90487-W PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA GP941 UT WOS:A1991GP94100004 PM 1745508 ER PT J AU BURROWS, EP AF BURROWS, EP TI FRAGMENT MOLECULE ADDUCT ION FORMATION IN THE MASS-SPECTRA OF CYCLIC N-ACETYLAMINES AND RELATED NITRAMINES SO ORGANIC MASS SPECTROMETRY LA English DT Article ID INDUCED DISSOCIATION; SPECTROMETRY; PATHWAYS AB Mass spectra of seven related N-heterocyclics, introduced by direct exposure probe, were determined in electron impact (EI) and positive- and negative-ion chemical ionization (PCI and NCI) modes. Proton adducts were the predominant molecular ion species in the EI and PCI modes. In addition, a variety of fragment-molecule adduct ions were observed for each compound in one or more of the modes. The propensity of 1,3,5-trinitrohexahydro-1,3,5-triazine for fragment-molecule adduct formation was high in all three ionization modes. Fragmentation process were documented by collision-induced dissociation experiments. RP BURROWS, EP (reprint author), USA,BIOMED RES & DEV LAB,FREDERICK,MD 21702, USA. NR 20 TC 4 Z9 4 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0030-493X J9 ORG MASS SPECTROM JI Org. Mass Spectrom. PD NOV PY 1991 VL 26 IS 11 BP 1027 EP 1031 DI 10.1002/oms.1210261123 PG 5 WC Chemistry, Organic; Spectroscopy SC Chemistry; Spectroscopy GA GP605 UT WOS:A1991GP60500022 ER PT J AU MURPHY, TP TELLER, DC AF MURPHY, TP TELLER, DC TI MAGNETIC-RESONANCE-IMAGING OF THE FACIAL-NERVE DURING BELLS-PALSY SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article; Proceedings Paper CT 1990 ANNUAL MEETING OF THE AMERICAN ACADEMY OF OTALARYNGOLOGY - HEAD AND NECK SURGERY CY SEP 09-13, 1990 CL SAN DIEGO, CA SP AMER ACAD OTOLARYNGOL HEAD & NECK SURG ID LESIONS AB Twenty-five patients with Bell's palsy were evaluated to assess the efficacy of gadolinium (Gd+)-enhanced MRI in determining: (1) the site of facial nerve enhancement, (2) the relationship between EMG findings and Gd+ MRIs, and (3) the usefulness of Gd+ MRI in predicting recovery of facial function. Eighteen of twenty-five patients had enhancement of the facial nerve during Gd+ MRI whereas seven did not. The most common areas of facial nerve enhancement were the labyrinthine, geniculate ganglion, and proximal tympanic segments of the facial nerve. EMGs were performed on ten patients who lost nerve excitability. The segments of facial nerve enhanced during Gd+ MRI varied in location and intensity in patients who maintained nerve excitability and in patients who lost nerve excitability. There was no correlation between EMG findings and location of facial nerve enhancement in patients who lost nerve excitability. The location of facial nerve enhancement during Gd+ MRI was not useful in predicting recovery of facial paralysis. C1 BROOKE ARMY MED CTR,DEPT EAR NOSE & THROAT,FT SAM HOUSTON,TX 78234. NR 6 TC 28 Z9 28 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD NOV PY 1991 VL 105 IS 5 BP 667 EP 674 PG 8 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA GP732 UT WOS:A1991GP73200006 PM 1754249 ER PT J AU BROWN, AE TEJAISAVADHARM, P WEBSTER, HK AF BROWN, AE TEJAISAVADHARM, P WEBSTER, HK TI MACROPHAGE ACTIVATION IN VIVAX MALARIA - FEVER IS ASSOCIATED WITH INCREASED LEVELS OF NEOPTERIN AND INTERFERON-GAMMA SO PARASITE IMMUNOLOGY LA English DT Article DE MALARIA; PLASMODIUM-VIVAX; MACROPHAGE; NEOPTERIN; INTERFERON-GAMMA ID TUMOR NECROSIS FACTOR; PLASMODIUM-FALCIPARUM MALARIA; SERUM LEVELS; EXPRESSION AB In order to evaluate the relationship between fever and macrophage activation in vivax malaria, serum interferon-gamma (IFN-gamma) and urinary neopterin concentrations were determined in Thai adults with Plasmodium vivax parasitaemia. Magnitude of fever, after controlling for parasite density, was found to be positively correlated with both IFN-gamma (r = 0.47) and neopterin (r = 0.57). In the 26 febrile patients, neopterin excretion increased further during the first two days of chemotherapy (P = 0.0002). Mean neopterin values for both groups had fallen to within the normal range by the sixth day post-treatment. Thus, the fever of vivax malaria was associated with IFN-gamma induced macrophage activation, as reflected by neopterin excretion. RP BROWN, AE (reprint author), ARMED FORCES RES INST MED SCI,DEPT IMMUNOL,315-6 RAJVITHI RD,BANGKOK 10400,THAILAND. NR 19 TC 19 Z9 19 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0141-9838 J9 PARASITE IMMUNOL JI Parasite Immunol. PD NOV PY 1991 VL 13 IS 6 BP 673 EP 679 DI 10.1111/j.1365-3024.1991.tb00562.x PG 7 WC Immunology; Parasitology SC Immunology; Parasitology GA GR632 UT WOS:A1991GR63200010 PM 1811217 ER PT J AU BALIS, FM BLANEY, SM POPLACK, DG AF BALIS, FM BLANEY, SM POPLACK, DG TI ANTIRETROVIRAL DRUG DEVELOPMENT AND CLINICAL-PHARMACOLOGY SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE ACQUIRED IMMUNODEFICIENCY SYNDROME; RETROVIRUS; ANTIRETROVIRAL DRUGS; ZIDOVADINE; DIDEOXYINOSINE; CHILDREN ID HUMAN IMMUNODEFICIENCY VIRUS; AIDS-RELATED COMPLEX; PHASE-I TRIAL; 2',3'-DIDEOXYINOSINE DDI; CEREBROSPINAL-FLUID; ANTIVIRAL THERAPY; ZIDOVUDINE AZT; RENAL-DISEASE; PHARMACOKINETICS; INFECTION C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP BALIS, FM (reprint author), NCI,PEDIAT BRANCH,BLDG 10,ROOM 13N240,BETHESDA,MD 20892, USA. NR 38 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD NOV PY 1991 VL 10 IS 11 BP 849 EP 857 DI 10.1097/00006454-199111000-00012 PG 9 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA GP048 UT WOS:A1991GP04800013 PM 1661004 ER PT J AU BUETOW, MP BUETOW, PC SMIRNIOTOPOULOS, JG AF BUETOW, MP BUETOW, PC SMIRNIOTOPOULOS, JG TI TYPICAL, ATYPICAL, AND MISLEADING FEATURES IN MENINGIOMA SO RADIOGRAPHICS LA English DT Article DE HEMANGIOPERICYTOMA; MENINGES; MENINGES; MR STUDIES; MENINGES; NEOPLASMS ID COMPUTED-TOMOGRAPHY; PERITUMORAL EDEMA; DIAGNOSIS; MR; NEOPLASMS; NEUROMAS; CT AB Meningiomas are the most common nonglial primary tumors of the central nervous system and the most common extraaxial neoplasms, accounting for approximately 15% of all intracranial tumors. They are usually benign neoplasms, with characteristic pathologic and imaging features. However, there are several important histologic variants of meningioma, and even a histologically typical meningioma can have unusual or misleading radiologic features that may not be suggestive of meningioma. The typical meningioma is a homogeneous, hemispheric, markedly enhancing extraaxial mass located over the cerebral convexity, in the parasagittal region, or arising from the sphenoid wing. Meningiomas may originate in unexpected locations such as the orbit, paranasal sinus, or ventricles or be entirely intraosseous (within the calvaria). Unusual imaging features such as large meningeal cysts, ring enhancement, and various metaplastic changes (including fatty transformation) can be particularly misleading. Because meningiomas are so common, the radiologist must be aware of their less frequent and uncharacteristic imaging features in order to suggest the correct diagnosis in cases that are atypical. C1 ARMED FORCES INST PATHOL,DEPT RADIOL PATHOL,BLDG 54,RM M121,ALASKA & FERN STS,WASHINGTON,DC 20306. PENN STATE UNIV,MILTON S HERSHEY MED CTR,DEPT RADIOL,HERSHEY,PA 17033. WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT RADIOL & NUCL MED,BETHESDA,MD 20814. RI Smirniotopoulos, James/D-3726-2011 NR 32 TC 106 Z9 117 U1 0 U2 4 PU RADIOLOGICAL SOC NORTH AMER PI EASTON PA 20TH AND NORTHAMPTON STS, EASTON, PA 18042 SN 0271-5333 J9 RADIOGRAPHICS JI Radiographics PD NOV PY 1991 VL 11 IS 6 BP 1087 EP 1106 PG 20 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA GP801 UT WOS:A1991GP80100014 PM 1749851 ER PT J AU ASCHER, DP ZBICK, C WHITE, C FISCHER, GW AF ASCHER, DP ZBICK, C WHITE, C FISCHER, GW TI INFECTIONS DUE TO STOMATOCOCCUS-MUCILAGINOSUS - 10 CASES AND REVIEW SO REVIEWS OF INFECTIOUS DISEASES LA English DT Review ID ENDOCARDITIS AB We describe 10 new cases of bacteremia due to Stomatococcus mucilaginosus and review eight other cases that have been described in the literature. The most common clinical presentations were endocarditis, catheter-related infection, and septicemia. Commonly associated risk factors were intravenous drug abuse, cardiac valve disease, the presence of foreign bodies (especially indwelling vascular catheters), and immunocompromised states. S. mucilaginosus bacteremia is readily treatable with antibiotics. This organism is of low virulence, but appears to be an emerging pathogen. Infection due to S. mucilaginosus is likely to be underreported because the organism may be easily misidentified and information on it is not included in the databases of many automated microbiologic identification systems. C1 WALTER REED ARMY MED CTR,DEPT CLIN MICROBIOL,WASHINGTON,DC 20307. RP ASCHER, DP (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT PEDIAT INFECT DIS,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. NR 17 TC 45 Z9 45 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0162-0886 J9 REV INFECT DIS PD NOV-DEC PY 1991 VL 13 IS 6 BP 1048 EP 1052 PG 5 WC Immunology; Microbiology SC Immunology; Microbiology GA GT753 UT WOS:A1991GT75300003 PM 1775836 ER PT J AU Glick, JH Maier, RS Rosen, JB AF Glick, J. H. Maier, R. S. Rosen, J. B. TI PARALLEL SOLUTION OF LARGE-SCALE, BLOCK-DIAGONAL CONCAVE MAXIMIZATION PROBLEMS SO SIAM JOURNAL ON OPTIMIZATION LA English DT Article DE nonlinear programming; large-scale problems; constrained optimization AB A feasible-point algorithm for structured, large-scale, constrained optimization problems which may have many nonlinear constraints is described. The constraint structure is characterized by a block-diagonal coefficient matrix corresponding to linear variables, coupled by nonlinear variables. Problems of this structure arise in many applications, including structural design optimization and certain multiperiod or multiplant applications. Maximization problems with a concave objective and concave inequality constraints which define a convex region are considered. For such problems a KKT point is a global maximum. A basic version of the algorithm is presented and justified by showing that it will find an optimal solution in a finite number of iterations. The algorithm has been implemented on a CRAY-2 and a 64-processor NCUBE hypercube. It has been tested on a series of randomly generated test problems, and its performance has been compared with that of MINOS 5.3. C1 [Glick, J. H.; Maier, R. S.; Rosen, J. B.] Univ Minnesota, Dept Comp Sci, Minneapolis, MN 55455 USA. [Maier, R. S.] Univ Minnesota, Army High Performance Comp Res Ctr, Minneapolis, MN 55415 USA. RP Glick, JH (reprint author), Univ Minnesota, Dept Comp Sci, Minneapolis, MN 55455 USA. FU Air Force Office of Scientific Research [AFOSR-87-0127]; Minnesota Supercomputer Institute, and the Army High Performance Computing Research Center FX This work was supported in part by Air Force Office of Scientific Research grant AFOSR-87-0127, the Minnesota Supercomputer Institute, and the Army High Performance Computing Research Center. NR 9 TC 1 Z9 1 U1 0 U2 0 PU SIAM PUBLICATIONS PI PHILADELPHIA PA 3600 UNIV CITY SCIENCE CENTER, PHILADELPHIA, PA 19104-2688 USA SN 1052-6234 EI 1095-7189 J9 SIAM J OPTIMIZ JI SIAM J. Optim. PD NOV PY 1991 VL 1 IS 4 BP 501 EP 514 DI 10.1137/0801030 PG 14 WC Mathematics, Applied SC Mathematics GA V40ST UT WOS:000209499000005 ER PT J AU LANDRY, FJ AF LANDRY, FJ TI ADVANCE DIRECTIVES - IMPLEMENTATION INTO CLINICAL-PRACTICE SO SOUTHERN MEDICAL JOURNAL LA English DT Article ID ELDERLY OUTPATIENTS AB Legislation recently passed by Congress will require health care organizations to maintain specific procedures regarding the right of patients to prepare advance directives. Previous studies have shown that patients may wish to discuss issues regarding future terminal care, but few patients complete living wills or durable powers of attorney. Although physicians often have positive attitudes regarding advance directives, the majority do not initiate discussions regarding these issues. The new regulations may increase the awareness of directives and increase the documentation of patients' desires into the medical record. However, the widespread acceptance of the advance directive and its impact on health care decisions remain to be seen. C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP LANDRY, FJ (reprint author), WALTER REED ARMY MED CTR,DEPT GEN INTERNAL MED,WASHINGTON,DC 20307, USA. NR 15 TC 1 Z9 1 U1 0 U2 0 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD NOV PY 1991 VL 84 IS 11 BP 1320 EP 1322 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA GR617 UT WOS:A1991GR61700007 PM 1948215 ER PT J AU DRABICK, JJ LANDRY, FJ AF DRABICK, JJ LANDRY, FJ TI SUPPURATIVE PYLEPHLEBITIS SO SOUTHERN MEDICAL JOURNAL LA English DT Article ID PORTAL-VEIN THROMBOSIS; DIAGNOSIS; PYLETHROMBOSIS; COMPLICATION; ABSCESS C1 WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. RP DRABICK, JJ (reprint author), WALTER REED ARMY MED CTR,DEPT NEUROENDOCRINOL,WASHINGTON,DC 20307, USA. NR 26 TC 11 Z9 11 U1 0 U2 0 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD NOV PY 1991 VL 84 IS 11 BP 1396 EP 1398 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA GR617 UT WOS:A1991GR61700028 PM 1948234 ER PT J AU CORRIE, D MUELLER, EJ THOMPSON, IM AF CORRIE, D MUELLER, EJ THOMPSON, IM TI MANAGEMENT OF ULTRASONICALLY DETECTED NONPALPABLE TESTIS MASSES SO UROLOGY LA English DT Article ID OCCULT TESTICULAR NEOPLASMS; TUMORS; ULTRASONOGRAPHY; GYNECOMASTIA; SONOGRAPHY AB As testicular ultrasound has evolved, nonpalpable masses have been detected for which an evaluation and treatment protocol has not been established. Our experience with nonpalpable testis masses detected only by ultrasound in 5 patients is presented, with all patients found to have nonmalignant lesions. We recommend that such cases with negative serum tumor markers and normal chest radiographs be followed with serial ultrasounds. Benign masses will resolve completely, while stable or enlarging masses can be locally excised and inguinal orchiectomy completed only if cancer is found by frozen section. A modified staging system to follow these patients is proposed to determine these patients' prognoses: Stage Ia for inguinally removed nonpalpable cancers, Stage Ib for excised nonpalpable cancers without orchiectomy (false-negative frozen section), and Stage Ic for inguinally removed palpable cancers. C1 BROOKE ARMY MED CTR,UROL SURG SERV,SAN ANTONIO,TX 78234. WALSON ARMY COMMUNITY HOSP,UROL SERV,FT DIX,NJ. NR 12 TC 18 Z9 18 U1 0 U2 0 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0090-4295 J9 UROLOGY JI UROLOGY PD NOV PY 1991 VL 38 IS 5 BP 429 EP 431 DI 10.1016/0090-4295(91)80231-U PG 3 WC Urology & Nephrology SC Urology & Nephrology GA GP380 UT WOS:A1991GP38000007 PM 1949452 ER PT J AU LITTLE, SF LOWE, JR AF LITTLE, SF LOWE, JR TI LOCATION OF RECEPTOR-BINDING REGION OF PROTECTIVE ANTIGEN FROM BACILLUS-ANTHRACIS SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS LA English DT Article ID DNA-SEQUENCE ANALYSIS; ESCHERICHIA-COLI; LETHAL TOXIN; PROTEINS; CHLORAMPHENICOL; CLONING; CELLS; GENE RP LITTLE, SF (reprint author), USA,MED RES INST INFECT DIS,DIV BACTERIOL,FT DETRICK,FREDERICK,MD 21701, USA. NR 22 TC 13 Z9 14 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0006-291X J9 BIOCHEM BIOPH RES CO JI Biochem. Biophys. Res. Commun. PD OCT 31 PY 1991 VL 180 IS 2 BP 531 EP 537 DI 10.1016/S0006-291X(05)81097-6 PG 7 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA GM638 UT WOS:A1991GM63800011 PM 1953724 ER PT J AU YAMASAKI, R BACON, BE NASHOLDS, W SCHNEIDER, H GRIFFISS, JM AF YAMASAKI, R BACON, BE NASHOLDS, W SCHNEIDER, H GRIFFISS, JM TI STRUCTURAL DETERMINATION OF OLIGOSACCHARIDES DERIVED FROM LIPOOLIGOSACCHARIDE OF NEISSERIA-GONORRHOEAE F62 BY CHEMICAL, ENZYMATIC, AND 2-DIMENSIONAL NMR METHODS SO BIOCHEMISTRY LA English DT Article ID 3-DEOXY-D-MANNO-OCT-2-ULOSONIC ACID KDO; ANTIGENIC EXPRESSION; HUMAN-ERYTHROCYTES; IDENTIFICATION; HETEROGENEITY; MENINGITIDIS; ANTIBODIES; LIPOPOLYSACCHARIDES; GLYCOSPHINGOLIPIDS; CHROMATOGRAPHY AB F62 LOS of Neisseria gonorrhoeae consists of two major LOS components; the higher and smaller molecular weight (MW) components were recognized by MAbs 1-1-M and 3F11 respectively. Base-line separation of the two major oligosaccharide (OS) components from F62 LOS was achieved by Bio-Gel P-4 chromatography after dephosphorylation of the OS mixture. The structures of the two major OSs were studied by chemical, enzymatic, and 2D NMR methods [double quantum filtered COSY (DQF-COSY), delayed COSY (D-COSY), homonuclear Hartmann-Hahn spectroscopy (HOHAHA), pure-absorption 2D NOE NMR] as well as methylation followed by GC/MS analysis. The OS component derived from the MAb 1-1-M defined LOS component was determined to have a V3-(beta-N-acetylgalactosaminyl)neolactotetraose structure (GalNAc is beta-1 --> 3-linked to a neolactotetraose) at one of its nonreducing termini as shown below. The above pentaose is linked to a branched diheptose-KDO core in which a GlcNAc is alpha-linked. The OS component derived from the MAb 3F11 defined LOS component did not have a GalNAc residue. The rest of its structure was identical to that of the OS-1, and a neolactotetraose is exposed at its nonreducing terminus. [GRAPHICS] C1 UNIV CALIF SAN FRANCISCO, DEPT LAB MED, SAN FRANCISCO, CA 94143 USA. UNIV CALIF SAN FRANCISCO, CTR IMMUNOCHEM, SAN FRANCISCO, CA 94143 USA. WALTER REED ARMY MED CTR, WASHINGTON, DC 20307 USA. RP YAMASAKI, R (reprint author), UNIV CALIF SAN FRANCISCO, VET ADM MED CTR, 113A, 4150 CLEMENT ST, SAN FRANCISCO, CA 94121 USA. FU NIAID NIH HHS [AI 22160, AI 22998] NR 35 TC 84 Z9 84 U1 1 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0006-2960 J9 BIOCHEMISTRY-US JI Biochemistry PD OCT 29 PY 1991 VL 30 IS 43 BP 10566 EP 10575 DI 10.1021/bi00107a028 PG 10 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA GM613 UT WOS:A1991GM61300028 PM 1931980 ER PT J AU RONG, FC BUCHWALD, WR HARMATZ, M POINDEXTER, EH WARREN, WL AF RONG, FC BUCHWALD, WR HARMATZ, M POINDEXTER, EH WARREN, WL TI ELECTRON-PARAMAGNETIC-RESONANCE STUDY OF THE ISOLATED ARSENIC ANTISITE IN ELECTRON-IRRADIATED GAAS AND ITS RELATION TO THE EL2 CENTER SO APPLIED PHYSICS LETTERS LA English DT Article ID SITE DEFECTS; IDENTIFICATION; ASGA; CONVERSION; RES AB Arsenic antisites produced in GaAs by room-temperature electron irradiation (RTEI) are examined by electron paramagnetic resonance (EPR). For the first time, this RTEI antisite, which has been believed to be the isolated antisite, is found to be metastable. The most efficient photon energy for photoquenching is found to be approximately 1.15 eV, which is very close to that observed for the well-known EL2 center in undoped semi-insulating GaAs. However, the thermal recovery temperature is about 200-250 K, much higher than that for the EL2 center. C1 USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. SANDIA NATL LABS,ALBUQUERQUE,NM 87185. NR 18 TC 2 Z9 2 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD OCT 28 PY 1991 VL 59 IS 18 BP 2281 EP 2283 DI 10.1063/1.106043 PG 3 WC Physics, Applied SC Physics GA GM040 UT WOS:A1991GM04000026 ER PT J AU HOWARD, SL AF HOWARD, SL TI POSSIBLE RESONANCE SCATTERING WINDOW FOR CO SYMMETRICAL CHARGE-TRANSFER SO CHEMICAL PHYSICS LETTERS LA English DT Article ID ENERGY; COLLISIONS; EXCHANGE; BEAM AB Comparison of scattering contour diagrams of CO+/CO symmetric charge transfer generated in low-energy crossed-beam experiments shows anomalous results at 1.1 eV collision energy as compared to results at 0.8 and 2.3 eV collision energy. Similarity with Ar+/N2 at 0.9 +/- 0.15 eV and Ar+/O2 near 0.85 eV may indicate a quantum-mechanical scattering resonance for CO+/CO near 1 eV as was postulated for these previous two systems. RP HOWARD, SL (reprint author), USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005, USA. NR 19 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD OCT 25 PY 1991 VL 185 IS 5-6 BP 452 EP 454 DI 10.1016/0009-2614(91)80241-O PG 3 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA GP334 UT WOS:A1991GP33400008 ER PT J AU COOPER, AB AF COOPER, AB TI FINDING BCH ERROR LOCATOR POLYNOMIALS IN ONE-STEP SO ELECTRONICS LETTERS LA English DT Article DE POLYNOMIALS; ERROR-CORRECTION CODES; INFORMATION THEORY AB Syndrome polynomials produced in a BCH decoder span an ideal in a multivariate polynomial ring. Because the error locators satisfy every member of the ideal, polynomial ideal theory is used to find another, more easily solvable system of equations having the same roots. One such equation is the (univariate) error locator polynomial. The Letter shows how to write this polynomial in one mathematical step from the syndrome polynomials. RP COOPER, AB (reprint author), USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005, USA. NR 5 TC 12 Z9 12 U1 0 U2 0 PU IEE-INST ELEC ENG PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD, ENGLAND SG1 2AY SN 0013-5194 J9 ELECTRON LETT JI Electron. Lett. PD OCT 24 PY 1991 VL 27 IS 22 BP 2090 EP 2091 PG 2 WC Engineering, Electrical & Electronic SC Engineering GA GN178 UT WOS:A1991GN17800060 ER PT J AU CRAMER, CJ TRUHLAR, DG AF CRAMER, CJ TRUHLAR, DG TI GENERAL PARAMETERIZED SCF MODEL FOR FREE-ENERGIES OF SOLVATION IN AQUEOUS-SOLUTION SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY LA English DT Article ID SOLVENT EFFECTS REPRESENTATION; ACCESSIBLE SURFACE-AREA; REACTION-FIELD METHOD; MONTE-CARLO; MOLECULAR MECHANICS; CHARGE MODEL; HYDROPHOBIC HYDRATION; SEMIEMPIRICAL METHODS; ELECTRONIC-STRUCTURE; POTENTIAL FUNCTIONS AB We present a new general parameterization for aqueous solvation free energies of molecules and ions in aqueous solution. It is obtained by extending a semianalytic treatment of solvation recently proposed for use with molecular mechanics and liquid simulations by Still et al. As extended here, the solvation terms are included in a Fock operator. The model incorporates reaction field polarization effects through the generalized Born functional with charges obtained by AM1 molecular orbital calculations, and it includes cavitation, dispersion, and hydrophobic effects through an empirical function of solvent-accessible surface area. A general parameter set, including parameters for H, C, N, O, F, S, Cl, Br, and I, has been obtained by considering a data set consisting of 141 neutral molecules, 10 cations, and 17 anions. The neutral molecules include alkanes, cycloalkanes, alkenes, arenes, alkynes, ethers, heterocycles, carboxylic acids, esters, nitriles, aldehydes, ketones, alcohols, amines, nitro compounds, sulfides, thiols, halides, and polyfunctional compounds. The general parameterization is called Solvation Model 1, and it is particularly well suited for chemical reaction dynamics and reaction intermediates. We also discuss how the model may be refined for solvation free energies for stable neutral molecules. C1 UNIV MINNESOTA, INST SUPERCOMP, DEPT CHEM, MINNEAPOLIS, MN 55455 USA. UNIV MINNESOTA, ARMY HIGH PERFORMANCE COMP RES CTR, MINNEAPOLIS, MN 55455 USA. RP USA, CTR CHEM RES DEV & ENGN, ABERDEEN PROVING GROUND, MD 21010 USA. RI Truhlar, Donald/G-7076-2015; Cramer, Christopher/B-6179-2011 OI Truhlar, Donald/0000-0002-7742-7294; Cramer, Christopher/0000-0001-5048-1859 NR 137 TC 496 Z9 497 U1 1 U2 32 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0002-7863 J9 J AM CHEM SOC JI J. Am. Chem. Soc. PD OCT 23 PY 1991 VL 113 IS 22 BP 8305 EP 8311 DI 10.1021/ja00022a017 PG 7 WC Chemistry, Multidisciplinary SC Chemistry GA GM038 UT WOS:A1991GM03800017 ER PT J AU CRAMER, CJ TRUHLAR, DG AF CRAMER, CJ TRUHLAR, DG TI MOLECULAR-ORBITAL THEORY CALCULATIONS OF AQUEOUS SOLVATION EFFECTS ON CHEMICAL-EQUILIBRIA SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY LA English DT Note ID GAS-PHASE BASICITIES; GROUND-STATES; TAUTOMERIC EQUILIBRIA; SEMIEMPIRICAL METHODS; PROTON AFFINITIES; PARAMETERS; WATER; TRANS; AM1; CIS C1 UNIV MINNESOTA, INST SUPERCOMP, DEPT CHEM, MINNEAPOLIS, MN 55455 USA. UNIV MINNESOTA, USA, CTR HIGH PERFORMANCE COMP RES, MINNEAPOLIS, MN 55455 USA. RP CRAMER, CJ (reprint author), USA, CTR CHEM RES DEV & ENGN, ABERDEEN PROVING GROUND, MD 21010 USA. RI Truhlar, Donald/G-7076-2015; Cramer, Christopher/B-6179-2011 OI Truhlar, Donald/0000-0002-7742-7294; Cramer, Christopher/0000-0001-5048-1859 NR 46 TC 101 Z9 102 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0002-7863 J9 J AM CHEM SOC JI J. Am. Chem. Soc. PD OCT 23 PY 1991 VL 113 IS 22 BP 8552 EP 8554 DI 10.1021/ja00022a069 PG 3 WC Chemistry, Multidisciplinary SC Chemistry GA GM038 UT WOS:A1991GM03800069 ER PT J AU AIN, KB REFETOFF, S FEIN, HG WEINTRAUB, BD AF AIN, KB REFETOFF, S FEIN, HG WEINTRAUB, BD TI PSEUDOMALABSORPTION OF LEVOTHYROXINE SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Note ID L-THYROXINE; MUNCHAUSENS SYNDROME; THYROID-HORMONE; TRIIODOTHYRONINE; HYPOTHYROIDISM; MALABSORPTION; ABSORPTION; CONVERSION; BYPASS AB Objective. - The issue of patient compliance with pharmacological therapy vs malabsorption of medication was explored in the context of persistent hypothyroidism despite the administration of large doses of levothyroxine sodium. Design. - Retrospective case series. Setting. - Referred care in two large tertiary care centers. Patients. - Four patients, seen within two decades, with clinical and biochemical hypothyroidism while receiving levothyroxine, were evaluated for selective malabsorption of this hormone. Interventions. - Studies included serial measurements of thyroid hormone levels after a loading dose of levothyroxine or liothyronine sodium or evaluation with a double-labeled thyroxine tracer technique. Results were compared with studies of levothyroxine malabsorption in the medical literature. Results. - All patients were ultimately found to have normal (82% to 100%) absorption of oral levothyroxine. There was no evidence that malabsorption of levothyroxine can occur as an isolated abnormality. Conclusions. - Some patients exhibit a factitious disorder suggesting malabsorption of levothyroxine. When treating hypothyroidism, psychiatric issues may result in noncompliance with levothyroxine therapy. C1 NIDDKD,METAB CELLULAR & NUTR ENDOCRINOL BRANCH,BETHESDA,MD. NIDDKD,CLIN ENDOCRINOL BRANCH,BETHESDA,MD. UNIV CHICAGO,DEPT MED,CHICAGO,IL 60637. UNIV CHICAGO,DEPT PEDIAT,CHICAGO,IL 60637. WALTER REED ARMY MED CTR,DEPT CLIN PHYSIOL,WASHINGTON,DC 20307. RI Ain, Kenneth/A-5179-2012 OI Ain, Kenneth/0000-0002-2668-934X FU NCRR NIH HHS [RR 00055]; NIDDK NIH HHS [DK 15070] NR 29 TC 50 Z9 52 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD OCT 16 PY 1991 VL 266 IS 15 BP 2118 EP 2120 DI 10.1001/jama.266.15.2118 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA GJ474 UT WOS:A1991GJ47400033 PM 1920700 ER PT J AU TARONE, RE HAYES, HM HOOVER, RN ROSENTHAL, JF BROWN, LM POTTERN, LM JAVADPOUR, N OCONNELL, KJ STUTZMAN, RE AF TARONE, RE HAYES, HM HOOVER, RN ROSENTHAL, JF BROWN, LM POTTERN, LM JAVADPOUR, N OCONNELL, KJ STUTZMAN, RE TI SERVICE IN VIETNAM AND RISK OF TESTICULAR CANCER SO JOURNAL OF THE NATIONAL CANCER INSTITUTE LA English DT Note ID UNITED-STATES; YOUNG MEN; PET DOGS; VETERANS; MORTALITY; HEALTH; TESTIS C1 WESTAT CORP, ROCKVILLE, MD USA. NCI, SURG BRANCH, DIV CANC TREATMENT, BETHESDA, MD 20892 USA. NATL NAVAL MED CTR, DEPT UROL, BETHESDA, MD 20814 USA. UNIFORMED SERV UNIV HLTH SCI, WALTER REED ARMY MED CTR, BETHESDA, MD 20814 USA. RP TARONE, RE (reprint author), NCI, DIV CANC ETIOL, EPIDEMIOL & BIOSTAT PROGRAM, EXECUT PLAZA N, ROOM 407, BETHESDA, MD 20892 USA. NR 26 TC 20 Z9 20 U1 0 U2 2 PU NATL CANCER INSTITUTE PI BETHESDA PA 9030 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0027-8874 J9 J NATL CANCER I JI J. Natl. Cancer Inst. PD OCT 16 PY 1991 VL 83 IS 20 BP 1497 EP 1499 DI 10.1093/jnci/83.20.1497 PG 3 WC Oncology SC Oncology GA GK022 UT WOS:A1991GK02200018 PM 1920497 ER PT J AU ENGHARDT, MH JORDAN, SE AF ENGHARDT, MH JORDAN, SE TI GRANULAR-CELL TUMOR OF A DIGITAL NERVE SO CANCER LA English DT Article ID NEURON SPECIFIC ENOLASE; S-100 PROTEIN; CARCINOEMBRYONIC ANTIGEN; MYOBLASTOMA; IMMUNOPEROXIDASE; LOCALIZATION; ORIGIN; LIGHT AB Granular cell tumor is an infrequently encountered albeit not rare neoplasm considered to be of neuroectodermal origin. An example of a benign granular cell tumor originating within a digital nerve is presented. The authors employed routine light microscopic techniques and immunostaining which demonstrate features of the granular cells reflecting structural and functional characteristics of Schwann's cells and support neuroectodermal derivation. Granular cell tumor is ubiquitous in location but occurs more frequently in tongue, skin, and subcutaneous tissue. Clinical features are not specific, and a histologic evaluation is required for diagnosis. Circumscription and lack of cellular pleomorphism define a benign process. However, irrespective of its histologic appearance, the biologic potential is uncertain. Complete excision suffices as treatment for benign tumors. C1 USN HOSP,DEPT ORTHOPAED,NEWPORT,RI. USN HOSP,DEPT PATHOL,NEWPORT,RI. KERLAN JOBE ORTHOPAED CLIN,INGLEWOOD,CA. RP ENGHARDT, MH (reprint author), BROOKE ARMY MED CTR,DEPT PATHOL,FT SAM HOUSTON,TX 78234, USA. NR 46 TC 15 Z9 15 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD OCT 15 PY 1991 VL 68 IS 8 BP 1764 EP 1769 DI 10.1002/1097-0142(19911015)68:8<1764::AID-CNCR2820680820>3.0.CO;2-# PG 6 WC Oncology SC Oncology GA GH289 UT WOS:A1991GH28900019 PM 1913521 ER PT J AU LYTLE, VI ACKLEY, SF AF LYTLE, VI ACKLEY, SF TI SEA ICE RIDGING IN THE EASTERN WEDDELL SEA SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID OCEAN AB In August 1986, sea ice ridge heights and spatial frequency in the eastern Weddell Sea were measured using a ship-based acoustical sounder. Using a minimum ridge sail height of 0.75 m, a total of 933 ridges were measured along a track length of 415 km. The ridge frequency varied from 0.4 to 10.5 ridges km-1. The mean height of the ridges was found to be about 1.1 m regardless of the ridge frequency. These results are compared to other ridging statistics from the Ross Sea and found to be similar. Comparison with Arctic data, however, indicates that the height and frequency of the ridges are considerably less in the Weddell Sea than in the Arctic. Whereas in the Arctic the mean ridge height tends to increase with the ridge frequency, we found that this was not the case in the Weddell Sea, where the mean ridge height remained constant irrespective of the ridge frequency. Estimates of the contribution of deformed ice to the total ice thickness are generally low except for a single 53-km section where the ridge frequency increased by an order of magnitude. This resulted in an increase in the equivalent mean ice thickness due to ridging from 0.04 m in the less deformed areas to 0.45 m in the highly deformed section. These values were found to be consistent with values obtained from drilled profile lines during the same cruise. RP LYTLE, VI (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 17 TC 24 Z9 24 U1 0 U2 1 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0148-0227 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD OCT 15 PY 1991 VL 96 IS C10 BP 18411 EP 18416 DI 10.1029/91JC01978 PG 6 WC Oceanography SC Oceanography GA GL027 UT WOS:A1991GL02700005 ER PT J AU COATES, RS RAMESH, KT AF COATES, RS RAMESH, KT TI THE RATE-DEPENDENT DEFORMATION OF A TUNGSTEN HEAVY ALLOY SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article ID HOPKINSON PRESSURE BAR; TEMPERATURE AB The rate-dependent deformation of a liquid-phase-sintered W-Ni-Fe (90%W-7%Ni-3%Fe) heavy alloy was investigated. The results of high strain rate tests (obtained using a compression Kolsky bar) combined with quasi-static data indicate that the compressive flow stress of this tungsten heavy alloy increases by perhaps 25% over a range of strain rates from 10(-4) s-1 up to about 7.0 x 10(3) s-1. The material appears to exhibit little or no strain hardening during these dynamic compressive deformations. Microhardness tests were performed on the two phases (the tungsten grains and the matrix) of the material both in the virgin state and after deformation at high strain rates to various levels of strain. The results from the microhardness measurements appear to indicate a greater hardening of the matrix phase than of the tungsten grains with increasing deformation. C1 USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005. RP COATES, RS (reprint author), JOHNS HOPKINS UNIV,DEPT MECH ENGN,CHARLES & 34 ST,BALTIMORE,MD 21218, USA. NR 29 TC 29 Z9 29 U1 0 U2 6 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0921-5093 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD OCT 15 PY 1991 VL 145 IS 2 BP 159 EP 166 DI 10.1016/0921-5093(91)90245-I PG 8 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA GP102 UT WOS:A1991GP10200004 ER PT J AU YU, FTS YANG, XY YIN, SZ GREGORY, DA AF YU, FTS YANG, XY YIN, SZ GREGORY, DA TI MIRROR-ARRAY OPTICAL INTERCONNECTED NEURAL NETWORK SO OPTICS LETTERS LA English DT Article ID ASSOCIATIVE-MEMORY; IMPLEMENTATION; CRYSTAL; MODEL; NETS AB A high-light-efficiency optical neural network that uses a mirror-array interconnection is proposed. Design considerations for the mirror array and experimental demonstration are given. C1 USA,MISSILE COMMAND,REDSTONE ARSENAL,AL 35898. RP YU, FTS (reprint author), PENN STATE UNIV,DEPT ELECT & COMP ENGN,UNIVERSITY PK,PA 16802, USA. NR 12 TC 2 Z9 3 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD OCT 15 PY 1991 VL 16 IS 20 BP 1602 EP 1604 DI 10.1364/OL.16.001602 PG 3 WC Optics SC Optics GA GK876 UT WOS:A1991GK87600018 PM 19777045 ER PT J AU CRAMER, CJ AF CRAMER, CJ TI CALCULATION OF THE ELECTRONIC-STRUCTURES AND SPECTRA OF SEVERAL ORGANIC AND INORGANIC RADICALS CONTAINING ALUMINUM SO THEOCHEM-JOURNAL OF MOLECULAR STRUCTURE LA English DT Article ID ABINITIO CONFIGURATION-INTERACTION; MOLECULAR-ORBITAL METHODS; HYPERFINE COUPLING-CONSTANTS; PARAMAGNETIC-RESONANCE DATA; ATOM-ACETYLENE COMPLEXES; SPIN-RESONANCE; MATRIX-ISOLATION; CATION RADICALS; NEON MATRICES; PHOTOCHEMICAL-REACTIONS AB Electronic structure calculations were performed for AlH+, AlH2, AlH-, AlF+, AlF2, AlH (OH), Al(OH)2, AlFO+, AlCH2, AlH(CH3), Al(CO)2, Al(C2H2) and Al(C2H4). Isotropic hyperfine coupling constants were predicted from unrestricted, MP2-spin-density-matrix-derived Fermi contact integrals and compared with experimental data. This relatively rapid, correlated method appears to be quite consistent and, after application of a roughly 10% scaling factor, reasonably accurate (+/- 0-20 G depending partly on the magnitude of the coupling constant). The method performs poorly, however, when the expected doublet molecular wavefunctions exhibit significant contamination from spin states of higher multiplicity. Based on these results, the spectral assignment of AlFO+ is questioned. The Al(CO)2 complex is shown to have a remarkably small central bond angle and to require consideration of correlation energy to exhibit a bound ground state. Commentary on the aluminum-acetylene and aluminum-ethylene complexes is offered. Theoretical IR data for AlF2, Al(OH)2, AlFO+ and Al(CO)2 are additionally provided. RP CRAMER, CJ (reprint author), USA,CTR CHEM RES DEV & ENGN,RES DIRECTORATE,DIV PHYS,ABERDEEN PROVING GROUND,MD 21010, USA. RI Cramer, Christopher/B-6179-2011 OI Cramer, Christopher/0000-0001-5048-1859 NR 88 TC 2 Z9 2 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-1280 J9 THEOCHEM-J MOL STRUC JI Theochem-J. Mol. Struct. PD OCT 15 PY 1991 VL 81 IS 3-4 BP 243 EP 262 PG 20 WC Chemistry, Physical SC Chemistry GA GN753 UT WOS:A1991GN75300004 ER PT J AU ARROYO, CM FORRAY, C AF ARROYO, CM FORRAY, C TI ACTIVATION OF CYCLIC-GMP FORMATION IN MOUSE NEUROBLASTOMA-CELLS BY A LABILE NITROXYL RADICAL - AN ELECTRON-PARAMAGNETIC RESONANCE SPIN TRAPPING STUDY SO EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION LA English DT Article DE CGMP; N1E-115 NEUROBLASTOMA CELLS; ELECTRON PARAMAGNETIC RESONANCE (EPR) SPIN TRAPPING; 3,5-DIBROMO-4-NITROSOBENZENE SULFONATE (DBNBS); NITRIC OXIDE-CONTAINING INTERMEDIATES; ENDOTHELIUM-DERIVED RELAXING FACTOR (EDRF) ID GUANYLATE-CYCLASE; NITRIC-OXIDE; L-ARGININE AB The receptor-mediated generation of an endothelial-derived relaxing factor (EDRF)-free radical intermediate in a neuronal cell line detected by spin trapping techniques has been reported. Here we report the time course of the appearance of the 3,5-dibromo-4-nitrosobenzene sulfonate (DBNBS) spin adduct and cyclic GMP formation following addition of carbamylcholine to suspensions of cultured mouse neuroblastoma cells (clone N1E-115). The time course of the appearance of the DBNBS spin adduct shows that spin adduct formation decreases possibly reaching a minimum approximately between 35 and 40 s. This is inversely proportional to cGMP formation which reaches a maximum at approximately 40 s after carbamylcholine activation. In addition, the inhibitory effect of N(G)-monomethyl-L-arginine (NMMA), potassium ferricyanide, K3Fe(CN)6 and methylene blue in cytosol preparation was investigated. A mechanism is proposed that essentially accounts for the combined results observed by spin trapping/electron paramagnetic resonance (EPR) study providing direct evidence for the muscarinic receptor-mediated formation of a labile, diffusible precursor of nitric oxide (NO.) derived from L-arginine that activates soluble guanylate cyclase. C1 VET ADM MED CTR,BALTIMORE,MD 21218. UNIV MARYLAND,DEPT PHARMACOL & TOXICOL,BALTIMORE,MD 21201. RP ARROYO, CM (reprint author), USA,MED RECH INST CHEM DEF,SGRD UV YY,ABERDEEN PROVING GROUND,MD 21010, USA. NR 14 TC 18 Z9 18 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0922-4106 J9 EUR J PHARM-MOLEC PH JI Eur. J. Pharmacol.-Molec. Pharmacol. Sect. PD OCT 14 PY 1991 VL 208 IS 2 BP 157 EP 161 DI 10.1016/0922-4106(91)90066-Q PG 5 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA GN046 UT WOS:A1991GN04600008 PM 1686865 ER PT J AU COULSON, NM JANUSZKIEWICZ, AJ RIPPLE, GR AF COULSON, NM JANUSZKIEWICZ, AJ RIPPLE, GR TI PHYSIOLOGICAL-RESPONSES OF SHEEP TO 2 HOURS ANESTHESIA WITH DIAZEPAM-KETAMINE SO VETERINARY RECORD LA English DT Article ID INDUCTION; XYLAZINE; HEART AB The cardiopulmonary effects of repeated intravenous injections of a combination of diazepam and ketamine for anaesthesia were evaluated in six domestic sheep. Induction doses of 0.375 mg/kg and 7.5 mg/kg were followed by maintenance doses of 0.188 mg/kg and 3.75 mg/kg every 15 minutes for 105 minutes. Although this dosing regimen produced the desired anaesthetic effects, it caused untoward cardiopulmonary effects. Salient features of multiple dosing with diazepam and ketamine were hypoventilation, respiratory acidosis and an increase in both systemic and pulmonary vascular resistance. C1 UNIV MARYLAND,SCH MED,DEPT PATHOL,BALTIMORE,MD 21201. WALTER REED ARMY MED CTR,DEPT RESP RES,WASHINGTON,DC 20307. RP COULSON, NM (reprint author), ROYAL ARMY VET CORPS,GALLWEY RD,ALDERSHOT GU11 2DQ,ENGLAND. NR 16 TC 6 Z9 6 U1 0 U2 5 PU BRITISH VETERINARY ASSOC PI LONDON PA 7 MANSFIELD ST, LONDON, ENGLAND W1M 0AT SN 0042-4900 J9 VET REC JI Vet. Rec. PD OCT 12 PY 1991 VL 129 IS 15 BP 329 EP 332 PG 4 WC Veterinary Sciences SC Veterinary Sciences GA GL180 UT WOS:A1991GL18000003 PM 1750174 ER PT J AU JUTAMULIA, S STORTI, GM GREGORY, DA KIRSCH, JC AF JUTAMULIA, S STORTI, GM GREGORY, DA KIRSCH, JC TI ILLUMINATION-INDEPENDENT HIGH-EFFICIENCY JOINT TRANSFORM CORRELATOR SO APPLIED OPTICS LA English DT Note AB A novel polarization-encoded two-channel joint transform correlator is described that can produce unity interference modulation, independent of the illumination of the target and the reference. C1 USA,MISSILE COMMAND,REDSTONE ARSENAL,AL 35898. RP JUTAMULIA, S (reprint author), QUANTEX CORP,2 RES COURT,ROCKVILLE,MD 20850, USA. NR 7 TC 47 Z9 47 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD OCT 10 PY 1991 VL 30 IS 29 BP 4173 EP 4175 PG 3 WC Optics SC Optics GA GL017 UT WOS:A1991GL01700003 PM 20706521 ER PT J AU CARSON, RT GIVENS, JH SAVAGE, HS LEE, YW RIGSBEE, JM CROISANT, WJ AF CARSON, RT GIVENS, JH SAVAGE, HS LEE, YW RIGSBEE, JM CROISANT, WJ TI REACTIVELY ION PLATED TIN - EFFECTS OF R.F. POWER-DENSITY ON THE STRUCTURE AND ELECTROCHEMICAL PROPERTIES SO THIN SOLID FILMS LA English DT Article ID THIN-FILMS; COATINGS; TOOLS AB Titanium nitride (TiN) thin film coatings were reactively ion plated onto Pyrex(R) glass and aluminum alloy 6061-T6 substrates while systematically varying the r.f. power density to evaluate its effect on the physical properties of the coating. X-ray diffraction, scanning electron microscopy, four-point probe resistivity and potentiodynamic polarization analysis techniques were used to evaluate the TiN coating crystal structure, morphology, resistivity and corrosion behavior. TiN coating properties were found to be strongly dependent on the r.f. power density up to approximately 1.5 W cm-2. Below 1.5 W cm-2, increasing r.f. power density resulted in improved electrochemical and resistivity properties. Above 1.5 W cm-2, many of the coating properties became independent of the r.f. power density. Correlations between the microstructures, properties and processing parameters are discussed. C1 USA,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL 61824. RP CARSON, RT (reprint author), UNIV ILLINOIS,DEPT MAT SCI & ENGN,1304 W GREEN ST,URBANA,IL 61801, USA. NR 12 TC 6 Z9 6 U1 2 U2 3 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0040-6090 J9 THIN SOLID FILMS JI Thin Solid Films PD OCT 10 PY 1991 VL 204 IS 2 BP 285 EP 296 DI 10.1016/0040-6090(91)90070-E PG 12 WC Materials Science, Multidisciplinary; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA GL265 UT WOS:A1991GL26500005 ER PT J AU ZIZI, M FISHER, RS GRILLO, FG AF ZIZI, M FISHER, RS GRILLO, FG TI FORMATION OF CATION CHANNELS IN PLANAR LIPID BILAYERS BY BREFELDIN-A SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Note ID GOLGI; RECONSTITUTION; PROTEINS; MEMBRANE; EXCHANGE AB Brefeldin A (BFA) is a novel agent with the unique property of effecting a rapid increase of Golgi cisternae volume and subsequent loss of a recognizable Golgi apparatus in treated cells. Although a receptor-mediated mechanism has been proposed, the molecular basis of BFA action remains unknown (Lippincott-Schwartz, J., Glickman, J., Donaldson, J. G., Robbins, J., Kreis, T. E., Seamon, K. B., Sheetz, M. P., and Klausner, R. D. (1991) J. Cell Biol. 112, 567-577). Since a variety of ionophores distort Golgi architecture by initially causing osmotic swelling of the cisternae (Mollenhauer, H. H., Morre, D. J., and Rowe, L. D. (1990) Biochim. Biophys. Acta 1031, 225-246), Golgi membrane permeabilization by BFA seemed possible. We examined the effects of BFA on the conductance of planar lipid bilayers bathed in several aqueous salt solutions. Addition of BFA (1-mu-g/ml) quickly augmented alkali cation conductance (K+ > Na+ >> Li+) but not anion conductance of the bilayer. Lower concentrations (1 ng/ml) indicated that BFA formed discrete, cation-selective channels in these bilayers. Given that Golgi cisternae volume increases immediately upon treatment with BFA, these findings suggest that alteration of ion gradients or Golgi membrane potential followed by an influx of water may be the mechanism by which BFA initiates disruption of Golgi structural integrity. Subsequent functional perturbations may then ensue either as a consequence of these initial structural changes or by a combination of several distinct mechanisms. C1 WALTER REED ARMY MED CTR,DEPT NEPHROL,WASHINGTON,DC 20307. NR 16 TC 16 Z9 16 U1 0 U2 0 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD OCT 5 PY 1991 VL 266 IS 28 BP 18443 EP 18445 PG 3 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA GJ472 UT WOS:A1991GJ47200009 PM 1717449 ER PT J AU HUDSON, TH GRILLO, FG AF HUDSON, TH GRILLO, FG TI BREFELDIN-A ENHANCEMENT OF RICIN A-CHAIN IMMUNOTOXINS AND BLOCKADE OF INTACT RICIN, MODECCIN, AND ABRIN SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID PROTEIN-SYNTHESIS INACTIVATION; TRANS-GOLGI NETWORK; DIPHTHERIA-TOXIN; ENDOPLASMIC-RETICULUM; INTERNALIZED RICIN; SECRETORY PROTEINS; INTRACELLULAR-TRANSPORT; MONOCLONAL-ANTIBODIES; RAT HEPATOCYTES; CELLS AB After binding, the protein toxins ricin, abrin, and modeccin are endocytosed and processed through the cell's vesicular system in a poorly understood fashion, prior to translocation to the cytosol. The role of the Golgi apparatus in toxin processing was studied using brefeldin-A (BFA), a fungal metabolite which blocks Golgi function. At concentrations that inhibit secretion of interleukin-2 (IL-2), BFA blocks ricin, modeccin, and abrin intoxication of a lymphocyte derived cell line (Jurkat). Paradoxically, BFA enhances the toxicity of two ricin A-chain immunotoxins targeted against distinct cell surface determinants. BFA concentrations which are optimal for immunotoxin enhancement are below those needed to affect ricin intoxication or IL-2 secretion. BFA blockade of ricin does not involve effects on ricin endocytosis, toxin translocation to the cytosol, or the enzymatic activity of toxin A-chain. In contrast, BFA has no effect on immunotoxin processing but does enhance the immunotoxin translocation step. It is concluded that: 1) intact Golgi function is required for holotoxin processing. 2) Intact Golgi function is not required for holotoxin translocation. 3) Golgi function is tightly linked to immunotoxin translocation. 4) BFA has effects on vesicular routing in addition to the block of Golgi function in secretion which has been reported. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV MED,DEPT NEPHROL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BIOL,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. NR 52 TC 55 Z9 55 U1 0 U2 1 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD OCT 5 PY 1991 VL 266 IS 28 BP 18586 EP 18592 PG 7 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA GJ472 UT WOS:A1991GJ47200031 PM 1917980 ER PT J AU SMITH, KJ SKELTON, HG JAMES, WD FRISSMAN, DM BARRETT, TL ANGRITT, P LUPTON, GP AF SMITH, KJ SKELTON, HG JAMES, WD FRISSMAN, DM BARRETT, TL ANGRITT, P LUPTON, GP TI PAPULAR ERUPTION OF HUMAN-IMMUNODEFICIENCY-VIRUS DISEASE - A REVIEW OF THE CLINICAL, HISTOLOGIC, AND IMMUNOHISTOCHEMICAL FINDINGS IN 48 CASES SO AMERICAN JOURNAL OF DERMATOPATHOLOGY LA English DT Review DE ACQUIRED IMMUNODEFICIENCY SYNDROME; HUMAN IMMUNODEFICIENCY VIRUS; PAPULAR ERUPTION; DERMAL DENDROCYTE; FACTOR XIIIA ID FACTOR-XIIIA; FIBROVASCULAR TUMORS; DERMAL DENDROCYTES; RETICULUM CELLS; DENDRITIC CELLS; HIV INFECTION; AIDS; LESIONS; SKIN; MANIFESTATIONS AB The papular eruption (PE) associated with human immunodeficiency virus infection, although described as a distinctive clinicopathologic entity, has shown a wide range of histologic findings ranging from eosinophilic folliculitis to granuloma annulare. We examined 48 cases of the PE in order to define the histologic spectrum of these lesions, and to correlate these findings with clinical presentations. The most distinctive clinical features are the frequency of these lesions in this population, the large number of lesions, pruritus, and the chronic nature of the lesions. Histologically, the distinctive features are the prominent perivascular factor XIIIa-positive dermal dendritic cells, atypical vascular proliferation, and dermal fibrosis sometimes associated with diffuse necrobiotic changes. C1 ARMED FORCES INST PATHOL,DEPT DERMATOPATHOL,WASHINGTON,DC 20306. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT DERMATOL,WASHINGTON,DC 20307. DEPT CELLULAR BIOL,WASHINGTON,DC. AIDS REGISTRY,WASHINGTON,DC. SCRIPPS CLIN & RES FDN,DEPT PATHOL,LA JOLLA,CA 92037. NR 47 TC 29 Z9 29 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0193-1091 J9 AM J DERMATOPATH JI Am. J. Dermatopathol. PD OCT PY 1991 VL 13 IS 5 BP 445 EP 451 DI 10.1097/00000372-199110000-00003 PG 7 WC Dermatology SC Dermatology GA GH668 UT WOS:A1991GH66800003 PM 1683178 ER PT J AU DIXON, K KIM, DH NANG, R HUH, J PARK, J HWANG, Y AF DIXON, K KIM, DH NANG, R HUH, J PARK, J HWANG, Y TI COMPARISON OF THE NEW CASE-CROSSOVER DESIGN WITH THE STANDARD UNMATCHED CASE-CONTROL DESIGN IN A STUDY OF RISK-FACTORS FOR KOREAN HEMORRHAGIC-FEVER IN SOLDIERS OF THE REPUBLIC-OF-KOREA SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract C1 USA,MED RES UNIT,APO,SAN FRANCISCO,CA 96301. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER J EPIDEMIOLOGY PI BALTIMORE PA 624 N BROADWAY RM 225, BALTIMORE, MD 21205 SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD OCT 1 PY 1991 VL 134 IS 7 BP 757 EP 758 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA GN535 UT WOS:A1991GN53500169 ER PT J AU LEVIN, LI MCNEIL, JG RENZULLO, PO LASLEYBIBBS, V PETERMAN, T AF LEVIN, LI MCNEIL, JG RENZULLO, PO LASLEYBIBBS, V PETERMAN, T TI RISK-FACTORS FOR HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) SEROCONVERSION AMONG HETEROSEXUAL MEN SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER J EPIDEMIOLOGY PI BALTIMORE PA 624 N BROADWAY RM 225, BALTIMORE, MD 21205 SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD OCT 1 PY 1991 VL 134 IS 7 BP 765 EP 766 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA GN535 UT WOS:A1991GN53500198 ER PT J AU COLES, EF STARNES, EC AF COLES, EF STARNES, EC TI USE OF HEMOQUANT ASSAYS TO ASSESS THE EFFECT OF ORAL IRON PREPARATIONS ON STOOL HEMOCCULT TESTS SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Article ID HEMOGLOBIN AB To determine whether oral iron preparations taken in therapeutic doses are capable of causing either true-positive, false-positive, or false-negative fecal occult blood Hemoccult tests, a prospective, before/after trial was conducted in the gastroenterology clinic of an Army medical center. Fourteen healthy volunteers were studied in four 1-wk periods, during which a single stool sample was collected on the 3rd, 5th, and 7th days for Hemoccult testing and HemoQuant assay. No iron preparations were ingested during the 1st and 3rd wk, and these results served as control values. One 324-mg tablet of ferrous sulfate was ingested orally three times each day during the 2nd wk and one 324-mg tablet of ferrous gluconate was ingested three times each day during the 4th wk of the study. All 84 stool specimens collected during the 2 wk of oral iron therapy were negative on Hemoccult testing, and the results of corresponding quantitative assays for fecal blood by the HemoQuant method were normal and did not differ significantly from control values. The Hemoccult test results from our study differ markedly from those of a previous study of similar design using only Hemoccult tests and oral iron preparations. Also, our HemoQuant data confirmed that oral iron preparations, in therapeutic doses, do not interfere with HemoQuant assay. Ferrous sulfate and ferrous gluconate tablets ingested in therapeutic doses do not cause false-positive, true-positive, or false-negative stool Hemoccult tests and do not cause a significant increase in gastrointestinal blood loss compared to controls as assessed by the HemoQuant assay. Any positive stool Hemoccult test detected in individuals ingesting therapeutic doses of oral iron preparations should not be regarded as a false-positive test. C1 BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,FT SAM HOUSTON,TX 78234. NR 7 TC 6 Z9 6 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 1991 VL 86 IS 10 BP 1442 EP 1444 PG 3 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA GJ410 UT WOS:A1991GJ41000009 PM 1928035 ER PT J AU BUCHANAN, TL BARKER, KN GIBSON, JT JIANG, BC PEARSON, RE AF BUCHANAN, TL BARKER, KN GIBSON, JT JIANG, BC PEARSON, RE TI ILLUMINATION AND ERRORS IN DISPENSING SO AMERICAN JOURNAL OF HOSPITAL PHARMACY LA English DT Article DE DISPENSING; ERRORS, MEDICATION; LIGHTING; PHARMACISTS, HOSPITAL; PHARMACY, INSTITUTIONAL, HOSPITAL; PLANNING AND DESIGN; PRESCRIPTIONS ID SHEET MATERIALS; INSPECTION; PHARMACISTS; ACCURACY; MODEL AB The relationship between the level of illumination and the prescription-dispensing error rate in a high-volume Army outpatient pharmacy was investigated. The prescription error rate was determined by direct, undisguised observation and retrospective prescription review under three levels of illumination (45, 102, and 146 foot-candles) during 21 consecutive weekdays. Illumination was controlled in the prescription-checking area of the pharmacy by using additional fluorescent lamps and filters. The three levels of illumination were randomly assigned to the 21 days to provide a total of 7 days of observations per level. The final sample consisted of 10,888 prescriptions dispensed by five pharmacists. The overall prescription error rate (including both content and labeling errors) was 3.39% (369 prescriptions). An illumination level of 146 foot-candles was associated with a significantly lower error rate (2.6%) than the baseline level of 45 foot-candles (3.8%). There was a linear relationship between each pharmacist's error rate and that pharmacist's corresponding daily prescription workload for all three illumination levels. The effect of the observer was minimal. The rate of prescription-dispensing errors was associated with the level of illumination. Ergonomics can affect the performance of professional tasks. C1 AUBURN UNIV,SCH PHARM,DEPT PHARM CARE SYST,PHARM FACIL DESIGN LAB,AUBURN,AL 36849. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. AUBURN UNIV,SCH IND ENGN,AUBURN,AL 36849. NR 51 TC 70 Z9 72 U1 1 U2 10 PU AMER SOC HEALTH-SYSTEM PHARMACISTS PI BETHESDA PA 7272 WISCONSIN AVE, BETHESDA, MD 20814 SN 0002-9289 J9 AM J HOSP PHARM JI Am. J. Hosp. Pharm. PD OCT PY 1991 VL 48 IS 10 BP 2137 EP 2145 PG 9 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA GH077 UT WOS:A1991GH07700017 PM 1781468 ER PT J AU BUTLER, JD LEVIN, SW FACCHIANO, A MUKHERJEE, AB AF BUTLER, JD LEVIN, SW FACCHIANO, A MUKHERJEE, AB TI CHARACTERIZATION OF CYSTINE BINDING-PROTEIN OF ESCHERICHIA-COLI SO AMERICAN JOURNAL OF HUMAN GENETICS LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NICHHD,BETHESDA,MD. NR 0 TC 0 Z9 0 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0002-9297 J9 AM J HUM GENET JI Am. J. Hum. Genet. PD OCT PY 1991 VL 49 IS 4 SU S BP 95 EP 95 PG 1 WC Genetics & Heredity SC Genetics & Heredity GA GR309 UT WOS:A1991GR30900446 ER PT J AU SURANA, RB RAFI, SK CHRISTOPHER, KL REID, TJ WEISS, RB AF SURANA, RB RAFI, SK CHRISTOPHER, KL REID, TJ WEISS, RB TI CONSTITUTIONAL HETEROMORPHISM OF 9Q13-GREATER-THAN-Q21 IN A PATIENT WITH CHRONIC MYELOGENOUS LEUKEMIA (CML) SO AMERICAN JOURNAL OF HUMAN GENETICS LA English DT Meeting Abstract C1 ARMED FORCES INST PATHOL,WASHINGTON,DC 20306. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0002-9297 J9 AM J HUM GENET JI Am. J. Hum. Genet. PD OCT PY 1991 VL 49 IS 4 SU S BP 251 EP 251 PG 1 WC Genetics & Heredity SC Genetics & Heredity GA GR309 UT WOS:A1991GR30901375 ER PT J AU LEVIN, SW SURANA, RB AF LEVIN, SW SURANA, RB TI HOLOPROSENCEPHALY ASSOCIATED WITH 46,XX,DEL(14)(Q11.1Q13) SO AMERICAN JOURNAL OF HUMAN GENETICS LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,WASHINGTON,DC 20306. NR 0 TC 11 Z9 12 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0002-9297 J9 AM J HUM GENET JI Am. J. Hum. Genet. PD OCT PY 1991 VL 49 IS 4 SU S BP 269 EP 269 PG 1 WC Genetics & Heredity SC Genetics & Heredity GA GR309 UT WOS:A1991GR30901483 ER PT J AU LEANACOX, J SURANA, R LEVIN, S SCHWARTZ, S AF LEANACOX, J SURANA, R LEVIN, S SCHWARTZ, S TI DETERMINATION OF THE ORIGIN OF DENOVO DUPLICATIONS USING CHROMOSOME-SPECIFIC DNA LIBRARIES SO AMERICAN JOURNAL OF HUMAN GENETICS LA English DT Meeting Abstract C1 UNIV MARYLAND,SCH MED,DIV HUMAN GENET,BALTIMORE,MD 21201. ARMED FORCES INST PATHOL,WASHINGTON,DC 20306. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0002-9297 J9 AM J HUM GENET JI Am. J. Hum. Genet. PD OCT PY 1991 VL 49 IS 4 SU S BP 301 EP 301 PG 1 WC Genetics & Heredity SC Genetics & Heredity GA GR309 UT WOS:A1991GR30901673 ER PT J AU KNIGHT, R PARSHAD, R PRICE, F SANFORD, K AF KNIGHT, R PARSHAD, R PRICE, F SANFORD, K TI CYTOGENETIC RESPONSE OF BLOOD-LYMPHOCYTES TO G2 PHASE X-IRRADIATION IN RELATION TO FAMILY HISTORY OF CANCER SO AMERICAN JOURNAL OF HUMAN GENETICS LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. HOWARD UNIV,WASHINGTON,DC 20059. NCI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0002-9297 J9 AM J HUM GENET JI Am. J. Hum. Genet. PD OCT PY 1991 VL 49 IS 4 SU S BP 473 EP 473 PG 1 WC Genetics & Heredity SC Genetics & Heredity GA GR309 UT WOS:A1991GR30902690 ER PT J AU HINKES, MJ AF HINKES, MJ TI WITNESSES FROM THE GRAVE - THE STORIES BONES TELL - JOYCE,C, STOVER,E SO AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY LA English DT Book Review RP HINKES, MJ (reprint author), USA,CENT IDENTIFICAT LAB,FT SHAFTER,HI 96858, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0002-9483 J9 AM J PHYS ANTHROPOL JI Am. J. Phys. Anthropol. PD OCT PY 1991 VL 86 IS 2 BP 311 EP 312 DI 10.1002/ajpa.1330860217 PG 2 WC Anthropology; Evolutionary Biology SC Anthropology; Evolutionary Biology GA GJ171 UT WOS:A1991GJ17100016 ER PT J AU WILSON, N YAKOLEFF, V CLAYBAUGH, JR AF WILSON, N YAKOLEFF, V CLAYBAUGH, JR TI BIG ANF - LARGE-MOLECULAR-WEIGHT ANF IN RABBIT PLASMA .2. ACID DISSOCIATION AND HPLC OF DISSOCIATED IRANF SO AMERICAN JOURNAL OF PHYSIOLOGY LA English DT Article DE IMMUNOREACTIVE ATRIAL NATRIURETIC FACTOR; ATRIOPEPTINS; CHROMATOGRAPHY; CIRCULATING; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY ID ATRIAL NATRIURETIC PEPTIDE; CIRCULATING FORM; RADIOIMMUNOASSAY; ATRIOPEPTIN AB A large-molecular-weight form of atrial natriuretic factor (ANF) was found in rabbit plasma. When extraction of plasma utilizing octadecylsilane cartridges is employed, this big ANF is not retained by the cartridge. When this material is dissociated with acid, immunoreactive ANF (irANF) is released. Of the acids tested, formic and acetic acid (0.05 M) were indicated as the most effective in causing the dissociation. High-performance liquid chromatography analysis of dissociated ANF, confirmed by coelution with synthetic peptides, disclosed the presence of ANF-(99-126) and ANF-(103-126) in a ratio of approximately 2:1. Atriopeptin I was detected in most of the samples analyzed, but atriopeptin II was only detected in one analysis. Despite the wide spectrum of the antiserum used for detection of irANF in the eluent fractions, only immunoreactive peaks coeluting with the four standards were detected. We therefore conclude that big ANF is a bound form of atrial peptides found in normal circulation. C1 TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96859. RP WILSON, N (reprint author), UNIV BRITISH COLUMBIA,FAC MED,DEPT PHYSIOL,2146 HLTH SCI MALL,VANCOUVER V6T 1Z3,BC,CANADA. NR 8 TC 8 Z9 8 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0002-9513 J9 AM J PHYSIOL JI Am. J. Physiol. PD OCT PY 1991 VL 261 IS 4 BP E525 EP E528 PN 1 PG 4 WC Physiology SC Physiology GA GK867 UT WOS:A1991GK86700037 PM 1833984 ER PT J AU HALL, DP SING, HC ROMANOSKI, AJ AF HALL, DP SING, HC ROMANOSKI, AJ TI IDENTIFICATION AND CHARACTERIZATION OF GREATER MOOD VARIANCE IN DEPRESSION SO AMERICAN JOURNAL OF PSYCHIATRY LA English DT Article ID AFFECTIVE-DISORDERS; RHYTHM; SCALE AB Objective: The authors sought to assess the quantity and quality of mood variation in depressed persons. Method: Using a visual analogue scale, they compared variation of mood in a group of patients (N = 9) with a DSM-III-R diagnosis of depressive disorder and in a group of nondepressed subjects (N = 9) over 12 consecutive hours. To quantify mood variation for each subject, the authors computed the standard deviation of each subject's 13 mood ratings on the visual analogue scale. To characterize the quality of mood variation within each subject, they plotted each subject's mood ratings as a function of time and applied complex demodulation to confirm cyclical patterns of mood variability (ultradian cycles). Results: The depressed group demonstrated greater mood score variability over the course of the day. Both groups demonstrated ultradian cycles and circadian trends; however, the depressed group demonstrated ultradian cycles of significantly greater amplitude than the nondepressed group. Conclusions: Repeated assessments of mood at different times of the day may be necessary to obtain an accurate impression of a patient's mood state. Further, the mechanism of depressive disorders may include a deregulation of a normal oscillatory mood variation pattern. C1 JOHNS HOPKINS UNIV HOSP,HENRY PHIPPS PSYCHIAT CLIN,BALTIMORE,MD 21205. RP HALL, DP (reprint author), WALTER REED ARMY MED CTR,DEPT PSYCHIAT,WASHINGTON,DC 20307, USA. NR 25 TC 30 Z9 30 U1 0 U2 0 PU AMER PSYCHIATRIC ASSOCIATION PI WASHINGTON PA 1400 K ST NW, WASHINGTON, DC 20005 SN 0002-953X J9 AM J PSYCHIAT JI Am. J. Psychiat. PD OCT PY 1991 VL 148 IS 10 BP 1341 EP 1345 PG 5 WC Psychiatry SC Psychiatry GA GH487 UT WOS:A1991GH48700009 PM 1897614 ER PT J AU RENZULLO, PO MCNEIL, JG GARDNER, LI BRUNDAGE, JF AF RENZULLO, PO MCNEIL, JG GARDNER, LI BRUNDAGE, JF TI INPATIENT MORBIDITY AMONG HIV-INFECTED MALE SOLDIERS PRIOR TO THEIR DIAGNOSIS OF HIV-INFECTION SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; AIDS; PATHOGENESIS; ZIDOVUDINE; EFFICACY; AZT AB Background. A natural history study of human immunodeficiency virus (HIV) disease was carried out among 1575 HIV-infected US Army men and 6220 demographically similar uninfected soldiers. Inpatient morbidity occurring up to 8 years prior to the date of HIV infection diagnosis among those men who became HIV infected was evaluated for both groups. Methods. Incidence density rates were calculated for hospital admissions. Poisson regression was used to assess the trend in hospital admissions among those subsequently diagnosed with HIV infection. Prevalence ratios for discharge diagnoses were also calculated. Results. Sixteen diagnoses/diagnosis categories occurred statistically more frequently among subsequently HIV diagnosed individuals than among those who remained uninfected. Among these were hepatitis B and abscess of anal/rectal region (6 to 8 years prior to HIV infection diagnosis); unspecified viral infection, enlarged lymph nodes, syphilis (3 to 5 years prior to HIV infection diagnosis); and diagnoses suggestive of acute retroviral syndrome (1 to 2 years prior to HIV infection diagnosis). Conclusions. Data such as these may provide useful information to HIV surveillance efforts regarding patterns of morbidity experienced prior to HIV infection as well as to health care providers regarding patients at high risk for becoming infected with HIV. RP RENZULLO, PO (reprint author), WALTER REED ARMY MED CTR,DEPT EPIDEMIOL,DIV PREVENT MED,WASHINGTON,DC 20307, USA. NR 21 TC 2 Z9 2 U1 0 U2 0 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 1015 FIFTEENTH ST NW, WASHINGTON, DC 20005 SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD OCT PY 1991 VL 81 IS 10 BP 1280 EP 1284 DI 10.2105/AJPH.81.10.1280 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA GX608 UT WOS:A1991GX60800009 PM 1928526 ER PT J AU TRUWIT, CL DENARO, CP LAKE, JR DEMARCO, T AF TRUWIT, CL DENARO, CP LAKE, JR DEMARCO, T TI MR IMAGING OF REVERSIBLE CYCLOSPORINE A-INDUCED NEUROTOXICITY SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article ID NERVOUS-SYSTEM TOXICITY; HYPERTENSIVE ENCEPHALOPATHY; CORTICAL BLINDNESS; ENDOTHELIN; TRANSPLANTATION; CONVULSIONS; METHYLPREDNISOLONE; CHOLESTEROL; SEIZURES; PEPTIDE AB Neurotoxicity is a recognized complication of cyclosporin A (CsA) therapy in patients undergoing organ transplantation. It is most commonly manifested by fever, seizures, and altered mental status. Cortical blindness and speech and motor disturbances can also occur. Changes seen in cerebral white matter on imaging studies are nonenhancing areas of hypoattenuation on CT and T2 prolongation on MR. We report three cases of CsA-induced neurotoxicity in which reversible changes were observed in the cerebral white matter. In the first patient, CsA neurotoxicity occurred 1 week following orthotopic liver transplantation. In the second patient, CsA neurotoxicity coincided with an episode of severe systemic hypertension 4 weeks after cardiac transplantation. The third patient experienced seizures 1 month after heart/lung transplantation for cystic fibrosis. A current theory postulates a relationship between diminished serum cholesterol and CsA neurotoxicity. This theory, however, does not satisfactorily address all cases of CsA neurotoxicity. In particular, serum cholesterol measurements were normal in cases 2 and 3 and probably were normal in case 1, despite diminished cholesterol levels preoperatively. Although the matter of CsA-induced neurotoxicity remains unresolved, we suggest that endothelin, a newly described neuropeptide that causes intense vasoconstriction and that has been implicated in cerebral vasospasm, may potentiate CsA-induced damage to endothelium and promote CsA neurotoxicity. C1 USA,ACAD HLTH SCI,DEPT ARMY MED,FT SAM HOUSTON,TX 78234. UNIV CALIF SAN FRANCISCO, E03E- X48LDIV CLIN PHARMACOL & EXPTL THERAPEUT,SAN FRANCISCO,CA 94143. UNIV CALIF SAN FRANCISCO,DIV CLIN PHARMACOL & EXPTL THERAPEUT,SAN FRANCISCO,CA 94143. UNIV CALIF SAN FRANCISCO,DEPT MED,LIVER TRANSPLANTAT SERV,SAN FRANCISCO,CA 94143. UNIV CALIF SAN FRANCISCO,CARD TRANSPLANTAT SERV,SAN FRANCISCO,CA 94143. NR 33 TC 1 Z9 1 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD OCT PY 1991 VL 157 IS 4 BP 851 EP 859 PG 9 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA GF743 UT WOS:A1991GF74300037 ER PT J AU HALL, WC CROWELL, TP WATTS, DM BARROS, VLR KRUGER, H PINHEIRO, F PETERS, CJ AF HALL, WC CROWELL, TP WATTS, DM BARROS, VLR KRUGER, H PINHEIRO, F PETERS, CJ TI DEMONSTRATION OF YELLOW-FEVER AND DENGUE ANTIGENS IN FORMALIN-FIXED PARAFFIN-EMBEDDED HUMAN LIVER BY IMMUNOHISTOCHEMICAL ANALYSIS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID DELTA-VIRUS-INFECTION; HEPATITIS; ANTIBODIES; DIAGNOSIS; TISSUE AB Two immunohistochemical techniques to determine the presence of yellow fever and dengue antigens in fixed tissue samples were developed for the purpose of making retrospective diagnoses of these viral diseases in humans. A horseradish peroxidase label was used for one technique and an alkaline phosphatase label for the other. In the former technique, acid hematin was removed from the tissues, iron-containing pigments were counterstained with Prussian blue, and the product of the diaminobenzidine reaction was enhanced with a dilute solution of osmium tetroxide that differentiated antigen from lipofuscin. In the latter technique, alkaline phosphatase was used as the enzyme labeling system with a red chromagen that contrasted nicely with the pigments in the tissues, as mentioned above. Thus, pigment removal or differentiation from antigen was not required. Replicate sections were cut and mouse polyclonal antibodies for yellow fever and all dengue types were applied to individual sections. On samples positive for dengue antigen, monoclonal antibodies were applied to additional replicate sections to demonstrate antigen of dengue types 1 and 4. In order to test the assay, samples of formalin-fixed liver tissue from Brazilian and Peruvian individuals who had died from a variety of causes as long as eight years earlier were received in a blinded fashion for immunohistochemical analysis. The techniques appeared to be highly reliable for yellow fever diagnosis; however, not enough cases were observed to adequately evaluate the procedures for dengue diagnosis. Both procedures appeared to have similar sensitivity. C1 PATHOL ASSOCIATES INC,FREDERICK,MD 21701. INST EVANDRO CHAGAS FUNDACAO SESP,BELEM,PARA,BRAZIL. CTR MED NAVAL,DEPT PATHOL,CALLAO,PERU. RP HALL, WC (reprint author), USA,MED RES INST INFECT DIS,DIV ASSESSMENT DIS,EDITORIAL OFF,FT DETRICK,FREDERICK,MD 21702, USA. NR 20 TC 105 Z9 116 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 1991 VL 45 IS 4 BP 408 EP 417 PG 10 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA GN354 UT WOS:A1991GN35400002 PM 1951849 ER PT J AU HENCHAL, EA POLO, SL VORNDAM, V YAEMSIRI, C INNIS, BL HOKE, CH AF HENCHAL, EA POLO, SL VORNDAM, V YAEMSIRI, C INNIS, BL HOKE, CH TI SENSITIVITY AND SPECIFICITY OF A UNIVERSAL PRIMER SET FOR THE RAPID DIAGNOSIS OF DENGUE VIRUS-INFECTIONS BY POLYMERASE CHAIN-REACTION AND NUCLEIC-ACID HYBRIDIZATION SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID ANTIBODY-CAPTURE ELISA; JAPANESE ENCEPHALITIS; INDIRECT IMMUNOFLUORESCENCE; MONOCLONAL-ANTIBODIES; NUCLEOTIDE-SEQUENCE; IDENTIFICATION; ANTIGEN; AMPLIFICATION; PROTEINS; DNA AB A set of sense and anti-sense oligomeric DNA primers, degenerate in the third "wobble" base position of codons so as to match all known dengue virus sequences, was evaluated as universal primers in a polymerase chain reaction (PCR) assay for the rapid diagnosis of dengue virus infections. Virus-specific complementary DNA (cDNA) was prepared by reverse transcription (RT) of total RNA extracted from serum. Amplified cDNA was identified by nucleic acid hybridization with four serotype-specific, oligomeric DNA probes. Using sera from patients admitted with dengue fever, RT/PCR followed by nucleic acid hybridization using radiolabeled probes was 68% sensitive (50/74; 95% confidence interval [CI] = 57-78%) and 100% specific. Chemiluminescent detection of hybridized products was 62% sensitive (26/42; 95% CI = 46-75%). Using specimens from which a virus isolate had been obtained, RT/PCR followed by nucleic acid hybridization with radiolabeled probes was 80% sensitive (40/50; 95% CI = 69-91%) and 100% specific. The results suggest that RT/PCR using degenerate primers is a sensitive and specific method for the detection of dengue viruses in clinical specimens. C1 WALTER REED ARMY MED CTR,DIV VIRUS DIS,WASHINGTON,DC 20307. CTR DIS CONTROL,SAN JUAN,PR 00936. ARMED FORCES RES INST MED SCI,APO,SAN FRANCISCO,CA. NR 43 TC 75 Z9 77 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 1991 VL 45 IS 4 BP 418 EP 428 PG 11 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA GN354 UT WOS:A1991GN35400003 PM 1951850 ER PT J AU KLEIN, TA LIMA, JBP TADA, MS MILLER, R AF KLEIN, TA LIMA, JBP TADA, MS MILLER, R TI COMPARATIVE SUSCEPTIBILITY OF ANOPHELINE MOSQUITOS IN RONDONIA, BRAZIL TO INFECTION BY PLASMODIUM-VIVAX SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID LINKED IMMUNOSORBENT-ASSAY; FIELD-EVALUATION; MALARIA; SPOROZOITES; CULICIDAE; DIPTERA; AREAS; FALCIPARUM; STATE AB Seven anopheline species from Costa Marques, Rondonia, Brazil were compared with Anopheles darlingi for susceptibility to infection by Plasmodium vivax. Laboratory-reared F1 progeny of field-collected An. darlingi and the test anopheline species were fed at the same time on the same patients, all of whom had gametocytes in peripheral blood before treatment. Mosquitoes were dissected on day 8 after infection for oocysts and on days 14-16 after infection for sporozoites. The mean numbers of P. vivax oocysts and the percent of salivary gland infections for An. darlingi and An. deaneorum were similar and far exceeded those found in the other anopheline species tested. Anopheles albitarsis and An. mediopunctatus were less susceptible to infection by oocyst measurements than An. darlingi. However, for oocyst-infected An. albitarsis and An. mediopunctatus, the percent of mosquitoes with salivary gland infections and the numbers of sporozoites in the salivary glands were similar to An. darlingi. Anopheles triannulatus and An. oswaldoi were both susceptible to P. vivax infection, but the sporozoite infection rates and the numbers of sporozoites observed in the salivary glands were very low. Anopheles braziliensis and An. benarrochi both developed oocysts, but were never observed to have sporozoites in the salivary glands. These studies implicate some anopheline species as potential malaria vectors, but also show that species previously incriminated by ELISA techniques are not vectors of malaria parasites in Costa Marques, Rondonia, Brazil. C1 UNIDADE MISTA COSTA MARQUES,SECRETARIA ESTADO RONDONIA,RONDONIA,BRAZIL. RP KLEIN, TA (reprint author), USA,MED RES UNIT BRAZIL,AMER CONSULATE RIO,APO,MIAMI,FL 34030, USA. NR 23 TC 71 Z9 78 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 1991 VL 45 IS 4 BP 463 EP 470 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA GN354 UT WOS:A1991GN35400008 PM 1951854 ER PT J AU KLEIN, TA TADA, MS LIMA, JBP KATSURAGAWA, TH AF KLEIN, TA TADA, MS LIMA, JBP KATSURAGAWA, TH TI INFECTION OF ANOPHELES-DARLINGI FED ON PATIENTS INFECTED WITH PLASMODIUM-VIVAX BEFORE AND DURING TREATMENT WITH CHLOROQUINE IN COSTA-MARQUES, RONDONIA, BRAZIL SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article AB Patients with asexual and sexual parasites of Plasmodium vivax were treated orally with 600 mg of chloroquine diphosphate al hour zero, followed by 300 mg at 8, 24 and 48 hr. Anopheles darlingi were fed before the first dose (-0.5 hr) and at 0.5, 1, 2, 4, 6, 8, 9, 10, 11, 12, 20, 24, 36, 48, 60, and 72 hr later. Mosquitoes were examined for oocysts on day 8 and sporozoites on day 15 after infection. The frequency of infected mosquitoes and the mean number of oocysts were lower in mosquitoes that fed on patients 2-4 hr after the initial dose of chloroquine than in mosquitoes fed before treatment and at 0.5 and 1 hr. This sporontocidal effect was temporary, since the frequency of infected mosquitoes and the mean number of oocysts increased in mosquitoes fed 4-8 hr after the first dose. Nearly all mosquitoes fed on patients after the third dose of chloroquine, at 24 hr, were negative for P. vivax oocysts. Oocysts in mosquitoes fed on patients before, during, and after chloroquine treatment appeared normal and produced sporozoites. We conclude that chloroquine affects either the gametocytes, fertilization, zygotes, and/or ookinetes of P. vivax, but not subsequent stages of development. C1 UNIDADE MISTA COSTA MARQUES,SECRETARIA ESTADO RONDONIA,RONDONIA,BRAZIL. RP KLEIN, TA (reprint author), USA,MED RES UNIT BRAZIL,AMER CONSULATE RIO,APO,MIAMI,FL 34030, USA. NR 18 TC 11 Z9 12 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 1991 VL 45 IS 4 BP 471 EP 478 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA GN354 UT WOS:A1991GN35400009 PM 1951855 ER PT J AU SHANKS, GD WATT, G EDSTEIN, MD WEBSTER, HK SURIYAMONGKOL, V WATANASOOK, C PANPUNNUNG, S KOWINWIPHAT, W AF SHANKS, GD WATT, G EDSTEIN, MD WEBSTER, HK SURIYAMONGKOL, V WATANASOOK, C PANPUNNUNG, S KOWINWIPHAT, W TI HALOFANTRINE FOR THE TREATMENT OF MEFLOQUINE CHEMOPROPHYLAXIS FAILURES IN PLASMODIUM-FALCIPARUM INFECTIONS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID THAILAND AB Thai soldiers who became slide-positive for malaria while receiving mefloquine chemoprophylaxis were treated with halofantrine to study its efficacy against mefloquine-resistant falciparum malaria. Thirty-two patients received three doses of 500 mg (1,500 mg total) of halofantrine at six-hr intervals, and were then observed for four weeks. Parasite recrudescence following treatment (median 21 days) occurred in seven of 23 patients (30%) who had mefloquine serum concentrations indicative of regular prophylaxis (> 500 ng/ml). Serum concentrations of mefloquine in all 32 patients averaged 950 ng/ml (range 26-2,515) prior to halofantrine treatment. The halofantrine serum concentrations were higher in patients cured by halofantrine than in patients with drug failure, but this was not statistically significant. Patients who were cured by halofantrine had parasites that were more sensitive in in vitro testing to mefloquine (mean [inhibitory concentration] IC50 = 12.5 ng/ml) than in patients whose parasitemias recrudesced (mean IC50 = 23.8 ng/ml) (P < 0.01, by Wilcoxon rank sum test). These observations suggest that the current formulation and regimen of halofantrine are not optimal for the treatment of multiple drug-resistant falciparum malaria from Thailand. C1 ARMED FORCES RES INST MED SCI,DEPT IMMUNOL,BANGKOK,THAILAND. ROYAL THAI NAVY,DEPT MED,BANGKOK,THAILAND. RP SHANKS, GD (reprint author), USA,MED COMPONENT,ARMED FORCES RES INST MED SCI,DEPT MED,APO AP,SAN FRANCISCO,CA 96546, USA. RI Shanks, George Dennis/F-4056-2014 OI Shanks, George Dennis/0000-0001-5763-8660 NR 7 TC 31 Z9 31 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 1991 VL 45 IS 4 BP 488 EP 491 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA GN354 UT WOS:A1991GN35400011 PM 1951857 ER PT J AU KNUTH, TE RICHARDS, JR AF KNUTH, TE RICHARDS, JR TI MAINSTEM BRONCHIAL OBSTRUCTION SECONDARY TO NASOTRACHEAL INTUBATION - A CASE-REPORT AND REVIEW OF THE LITERATURE SO ANESTHESIA AND ANALGESIA LA English DT Article ID BLIND NASAL INTUBATION; COMPLICATIONS C1 TRIPLER ARMY MED CTR,DEPT SURG & ANESTHESIOL,HONOLULU,HI 96859. TRIPLER ARMY MED CTR,OPERAT SERV,HONOLULU,HI 96859. NR 12 TC 14 Z9 14 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD OCT PY 1991 VL 73 IS 4 BP 487 EP 489 PG 3 WC Anesthesiology SC Anesthesiology GA GG685 UT WOS:A1991GG68500021 PM 1897774 ER PT J AU STRONG, WE AF STRONG, WE TI EPIDURAL ABSCESS ASSOCIATED WITH EPIDURAL CATHETERIZATION - REPLY SO ANESTHESIOLOGY LA English DT Letter RP STRONG, WE (reprint author), BROOKE ARMY MED CTR,PAIN CLIN,FT SAM HOUSTON,TX 78234, USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD OCT PY 1991 VL 75 IS 4 BP 709 EP 709 DI 10.1097/00000542-199110000-00034 PG 1 WC Anesthesiology SC Anesthesiology GA GH568 UT WOS:A1991GH56800033 ER PT J AU WHITE, EL BUCKHEIT, RW ROSS, LJ GERMANY, JM ANDRIES, K PAUWELS, R JANSSEN, PAJ SHANNON, WM CHIRIGOS, MA AF WHITE, EL BUCKHEIT, RW ROSS, LJ GERMANY, JM ANDRIES, K PAUWELS, R JANSSEN, PAJ SHANNON, WM CHIRIGOS, MA TI A TIBO DERIVATIVE, R82913, IS A POTENT INHIBITOR OF HIV-1 REVERSE-TRANSCRIPTASE WITH HETEROPOLYMER TEMPLATES SO ANTIVIRAL RESEARCH LA English DT Article DE TIBO; HIV-1; HIV-2; REVERSE TRANSCRIPTASE; NOVEL RNA TEMPLATE ID SUBSTRATE; DNA AB R82913, (+)-S-4,5,6,7-tetrahydro-9-chloro-5-methyl-6-(3-methyl-2-butenyl) imidazo[4,5,1-jk][1,4]-benzodiazepin-2(1H)-thione (a TIBO derivative), inhibited the replication of thirteen different strains of HIV-1 in CEM cells with a median IC50 of 0.15-mu-M. The concentration of compound that killed 50% of the cells was much higher (46-mu-M), indicating that R82913 has a high selectivity index. R82913 was 20-fold more potent than AZT-TP in the inhibition of HIV-1 reverse transcriptase in an assay using a naturally occurring template (ribosomal RNA) that more accurately resembles native viral RNA than a synthetic homopolymer. With this template, R82913 inhibited HIV-1 reverse transcriptase with an ID50 (0.01-mu-M) that is equal to, or lower than, the IC50 for this compound in all of our cell culture assays (0.01-0.65-mu-M). R82913 has no effect on the replication of HIV-2 in CEM cells and does not inhibit the reverse transcriptase from this virus. C1 KETTERING MEYER LABS,SOUTHERN RES INST,BIRMINGHAM,AL 35205. JANSSEN PHARMACEUT,B-2340 BEERSE,BELGIUM. CATHOLIC UNIV LEUVEN,B-3000 LOUVAIN,BELGIUM. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. FU NIAID NIH HHS [5U01-AI25617] NR 9 TC 82 Z9 83 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 J9 ANTIVIR RES JI Antiviral Res. PD OCT PY 1991 VL 16 IS 3 BP 257 EP 266 PG 10 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA GN836 UT WOS:A1991GN83600005 PM 1725247 ER PT J AU STRONG, WE WESLEY, R WINNIE, AP AF STRONG, WE WESLEY, R WINNIE, AP TI EPIDURAL STEROIDS ARE SAFE AND EFFECTIVE WHEN GIVEN APPROPRIATELY SO ARCHIVES OF NEUROLOGY LA English DT Letter ID INJECTIONS C1 UNIV ILLINOIS HOSP,CTR PAIN CONTROL,CHICAGO,IL 60612. RP STRONG, WE (reprint author), BROOKE ARMY MED CTR,PAIN CLIN STAFF,ANESTHESIA & OPERAT SERV,FT SAM HOUSTON,TX 78234, USA. NR 10 TC 10 Z9 11 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-9942 J9 ARCH NEUROL-CHICAGO JI Arch. Neurol. PD OCT PY 1991 VL 48 IS 10 BP 1012 EP 1012 PG 1 WC Clinical Neurology SC Neurosciences & Neurology GA GJ526 UT WOS:A1991GJ52600005 PM 1929890 ER PT J AU MOORE, DH SMALLRIDGE, RC VONBREDOW, JD LUKEY, BJ AF MOORE, DH SMALLRIDGE, RC VONBREDOW, JD LUKEY, BJ TI THE PHARMACOKINETICS OF ATROPINE AND DIAZEPAM IN SHEEP - INTRAMUSCULAR COADMINISTRATION SO BIOPHARMACEUTICS & DRUG DISPOSITION LA English DT Article DE ATROPINE; DIAZEPAM; PHARMACOKINETICS; SHEEP; INTRAMUSCULAR ID SOMAN; NEUROPATHOLOGY AB The purpose of this study was to determine whether the co-administration of atropine and diazepam affect the rate and extent of absorption of either drug. A triple crossover pharmacokinetic study using adult sheep was conducted. Each of nine animals received single injections of atropine (2 mg), diazepam (10 mg), and a combination of the two compounds weekly over a 3-week period. The combination of the drugs was injected into a single intramuscular site through a specially designed tandem syringe. Blood samples were obtained from time 0 to 300 min post-injection. Serum samples were analyzed for atropine by radioimmunoassay and for diazepam by gas chromatography/mass spectrometry. Pharmacokinetic parameters were evaluated by non-compartmental analysis. The co-administration of atropine and diazepam intramuscularly in sheep caused a delay in the time to reach maximal concentration of atropine. However, at the time when a single injection of atropine reached its maximum serum concentration, 92 per cent of that concentration was reached by atropine in the presence of diazepam. Additionally, no difference was detected in the rate or extent of diazepam absorption when administered intramuscularly in combination with atropine at the same site. RP MOORE, DH (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 22 TC 6 Z9 6 U1 0 U2 2 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0142-2782 J9 BIOPHARM DRUG DISPOS JI Biopharm. Drug Dispos. PD OCT PY 1991 VL 12 IS 7 BP 525 EP 536 DI 10.1002/bdd.2510120706 PG 12 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA GH983 UT WOS:A1991GH98300005 PM 1932614 ER PT J AU BRENNAN, P JOHNSON, D RIDER, S CONE, N GOLDMAN, M BUCKPITT, A CHUNG, H AF BRENNAN, P JOHNSON, D RIDER, S CONE, N GOLDMAN, M BUCKPITT, A CHUNG, H TI DERMAL ABSORPTION OF NICLOSAMIDE IN RATS AND MINIPIGS SO BIOPHARMACEUTICS & DRUG DISPOSITION LA English DT Article DE NICLOSAMIDE; DERMAL ABSORPTION; SCHISTOSOMIASIS; WR-046234; RATS; MINIPIGS AB The dermal absorption of niclosamide, a drug shown to prevent Schistosomiasis by blocking the dermal penetration of cercariae, has been examined in Sinclair minipigs and rats. Radioactivity in the urine and feces collected daily for 7 days after application of C-14-niclosamide accounted for less than 2 per cent and 10 per cent of the labelled compound applied to pig and rat skin, respectively. Approximately 20 per cent of the radioactivity from the dose solution was recovered on the skin excised from the area of application in both minipigs and rats. No radioactivity was detected in organs removed from the pig 7 days after application of radiolabelled drug while less than 6 per cent of the dose could be accounted for in the rat organs/carcass. Radioactivity in swine blood, removed 0.5, 1, 2, 4 and at 24 h intervals after dosing, was at or below three times background in all of the samples. Total recovery of the applied radioactivity was 78 per cent in pigs and 57 per cent in rats. These studies indicate that niclosamide is very poorly absorbed after dermal application. The results are consistent with earlier comparative studies showing that dermal penetration of xenobiotics in rats is generally higher than in swine. C1 UNIV CALIF DAVIS,SCH VET MED,DEPT PHARMACOL & TOXICOL,HARING HALL,DAVIS,CA 95616. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIV CALIF DAVIS,SCH VET MED,DEPT RADIOL SCI,DAVIS,CA 95616. NR 10 TC 1 Z9 3 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0142-2782 J9 BIOPHARM DRUG DISPOS JI Biopharm. Drug Dispos. PD OCT PY 1991 VL 12 IS 7 BP 547 EP 556 DI 10.1002/bdd.2510120708 PG 10 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA GH983 UT WOS:A1991GH98300007 PM 1932616 ER PT J AU SNYDER, AP WINDIG, W TOTH, JP AF SNYDER, AP WINDIG, W TOTH, JP TI INTERACTIVE SELF-MODELING MULTIVARIATE-ANALYSIS OF THERMOLYSIS MASS-SPECTRA SO CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS LA English DT Article ID ATMOSPHERIC-PRESSURE; CHEMICAL IONIZATION; COMPONENT SPECTRA; BIO-POLYMERS; PYROLYSIS; SPECTROMETRY; MIXTURES AB Traditionally, multivariate data analysis has been characterized as cross-reference (i.e. principal components, spectra, loading and score lists) intensive in terms of data reduction, as well as conceptually difficult to understand. The variance diagram (VARDIA) greatly simplified multivariate analysis by shifting the burden from complex lists of data variable statistics to visually informative depictions of the data set. The visually oriented VARDIA technique was combined with the KEY SET algorithm developed by Malinowski, and their union, the Interactive Self-Modeling Multivariate Analysis (ISMA) technique, was shown to be particularly effective for identifying pure component spectra in time-resolved Raman and Fourier transform IR spectral data sets. Furthermore, color labeling of the pure variables and components, which also characterizes the ISMA approach, provided enormous benefits with respect to data analysis and user interaction. In the present study, time-resolved atmospheric pressure ionization thermolysis mass spectra of biopolymers, biopolymer mixtures and microorganisms are investigated by the ISMA approach. A straightforward, user-friendly resolution of the mass spectra was realized by color-graphics displays of the ISMA technique. Color is not only a convenient tool in the data reduction process, but it also acts as a link between the multivariate and original data sets. Separate components could be traced via their color in the VARDIA, pure masses and standard deviation mass spectra. C1 EASTMAN KODAK CO,CHEMOMETR LAB,ROCHESTER,NY 14650. UNIV FLORIDA,INST FOOD & AGR SCI,GAINESVILLE,FL 32611. RP SNYDER, AP (reprint author), USA,CHEM CTR RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010, USA. NR 17 TC 8 Z9 9 U1 1 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-7439 J9 CHEMOMETR INTELL LAB JI Chemometrics Intell. Lab. Syst. PD OCT PY 1991 VL 11 IS 2 BP 149 EP 160 DI 10.1016/0169-7439(91)80062-U PG 12 WC Automation & Control Systems; Chemistry, Analytical; Computer Science, Artificial Intelligence; Instruments & Instrumentation; Mathematics, Interdisciplinary Applications; Statistics & Probability SC Automation & Control Systems; Chemistry; Computer Science; Instruments & Instrumentation; Mathematics GA GN731 UT WOS:A1991GN73100005 ER PT J AU SHANLEY, DJ VASSALLO, CJ BUCKNER, AB AF SHANLEY, DJ VASSALLO, CJ BUCKNER, AB TI STERNOCLAVICULAR PYARTHROSIS DEMONSTRATED ON BONE-SCAN - CORRELATION WITH CT AND MRI SO CLINICAL NUCLEAR MEDICINE LA English DT Note ID COMPUTED-TOMOGRAPHY RP SHANLEY, DJ (reprint author), TRIPLER ARMY MED CTR,DEPT RADIOL & NUCL MED,HONOLULU,HI 96859, USA. NR 3 TC 3 Z9 3 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD OCT PY 1991 VL 16 IS 10 BP 786 EP 787 DI 10.1097/00003072-199110000-00021 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA GK004 UT WOS:A1991GK00400021 PM 1742939 ER PT J AU HAIBACH, H BURNS, TW CARLSON, HE BURMAN, KD DEFTOS, LJ AF HAIBACH, H BURNS, TW CARLSON, HE BURMAN, KD DEFTOS, LJ TI COWDENS DISEASE ASSOCIATED WITH MERKEL CELL-CARCINOMA AND RENAL-CELL CARCINOMA SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 NORTHPORT MED CTR,MED SERV,STONY BROOK,NY. UNIV MISSOURI,DEPT PATHOL,COLUMBIA,MO 65201. UNIV MISSOURI,DEPT MED,COLUMBIA,MO 65201. WALTER REED ARMY MED CTR,ENDOCRINE SERV,WASHINGTON,DC 20307. VET ADM MED CTR,DEPT MED,SAN DIEGO,CA 92161. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD OCT PY 1991 VL 39 IS 3 BP A704 EP A704 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA GF369 UT WOS:A1991GF36900240 ER PT J AU BANDICK, NR ROBERTS, DE AF BANDICK, NR ROBERTS, DE TI INTRINSIC ALTERATION OF THE REACTIVE PROPERTIES OF ARTERIES DURING HYPOTHERMIA SO CRYOBIOLOGY LA English DT Article ID CANINE CUTANEOUS VEINS; SMOOTH-MUSCLE; PHOSPHORYLATION; TEMPERATURE; MYOSIN; DOG C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 15 TC 3 Z9 3 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0011-2240 J9 CRYOBIOLOGY JI Cryobiology PD OCT PY 1991 VL 28 IS 5 BP 499 EP 502 DI 10.1016/0011-2240(91)90060-2 PG 4 WC Biology; Physiology SC Life Sciences & Biomedicine - Other Topics; Physiology GA GJ432 UT WOS:A1991GJ43200013 PM 1752136 ER PT J AU MOSES, FM BASKA, RS PEURA, DA DEUSTER, PA AF MOSES, FM BASKA, RS PEURA, DA DEUSTER, PA TI EFFECT OF CIMETIDINE ON MARATHON-ASSOCIATED GASTROINTESTINAL SYMPTOMS AND BLEEDING SO DIGESTIVE DISEASES AND SCIENCES LA English DT Article DE GASTROINTESTINAL BLEEDING; CIMETIDINE; RUNNING ID LONG-DISTANCE RUNNERS; GASTRIC-SECRETION; BLOOD-LOSS; EXERCISE; ANEMIA AB Occult gastrointestinal bleeding occurs in 8-30% of marathon runners. We hypothesized that cimetidine would decrease bleeding by reducing acid-mediated injury and conducted a blinded, placebo-controlled prospective trial to determine the impact of cimetidine on gastrointestinal symptoms and bleeding during a marathon. Thirty participants in the 1989 Marine Corps or New York City marathons completed pre- and postrace: (1) a questionnaire evaluating demographic, medication usage, training history, and gastrointestinal symptoms; (2) three consecutive stool Hemoccult (HO) cards; and (3) a stool Hemoquant (HQ). Fourteen runners (CR) took 800 mg of cimetidine b mouth 2 hr before the start and 16 runners (PR) took placebo. Three subjects were HO+ prerace and were not analyzed. Three subjects failed to take drug as directed and were analyzed as PR. Five of 14 PR and two of 13 CR were HO+ postrace (P > 0.05). Prerace HQ values (PR: 1.49 +/- 0.6 and CR: 0.60 +/- 0.1 mg hemoglobin/g stool) were not significantly different from postrace HQ values (PR: 0.73 +/- 0.2 and CR: 0.86 +/- 0.2 mg Hgb/g stool). Despite postrace HO+ conversion, no individual postrace HQ became abnormal. The frequency of gastrointestinal symptoms was similar for CR and PR, as well as HO- and HO+ individuals. Cimetidine did not significantly affect occult gastrointestinal bleeding as measured by HO or HQ results. This suggests that marathon-associated gastrointestinal symptoms and bleeding may be due to lesions other than acid-mediated disease or hemorrhagic gastritis. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT MILITARY MED,HUMAN PERFORMANCE LAB,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT SURG,WASHINGTON,DC 20307. RP MOSES, FM (reprint author), WALTER REED ARMY MED CTR,GASTROENTEROL SERV,WASHINGTON,DC 20307, USA. RI Deuster, Patricia/G-3838-2015 OI Deuster, Patricia/0000-0002-7895-0888 NR 23 TC 16 Z9 16 U1 0 U2 0 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0163-2116 J9 DIGEST DIS SCI JI Dig. Dis. Sci. PD OCT PY 1991 VL 36 IS 10 BP 1390 EP 1394 DI 10.1007/BF01296804 PG 5 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA GM087 UT WOS:A1991GM08700008 PM 1914760 ER PT J AU PERRY, EB AF PERRY, EB TI THE TETON DAM FAILURE - PROBLEMS WITH THE USE OF LOESS MATERIAL IN EARTH DAM STRUCTURES - COMMENTS SO ENGINEERING GEOLOGY LA English DT Editorial Material RP PERRY, EB (reprint author), WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 0 TC 1 Z9 1 U1 1 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0013-7952 J9 ENG GEOL JI Eng. Geol. PD OCT PY 1991 VL 31 IS 2 BP 205 EP 206 DI 10.1016/0013-7952(91)90007-8 PG 2 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA GL616 UT WOS:A1991GL61600007 ER PT J AU SCHRIEFER, ME SACCI, JB WIRTZ, RA AZAD, AF AF SCHRIEFER, ME SACCI, JB WIRTZ, RA AZAD, AF TI DETECTION OF POLYMERASE CHAIN REACTION-AMPLIFIED MALARIAL DNA IN INFECTED BLOOD AND INDIVIDUAL MOSQUITOS SO EXPERIMENTAL PARASITOLOGY LA English DT Article ID PLASMODIUM-FALCIPARUM; SURFACE-ANTIGEN; DIAGNOSIS; HYBRIDIZATION; SPOROZOITE; DIVERSITY; PROBE; GENE C1 UNIV MARYLAND,SCH MED,DEPT MICROBIOL & IMMUNOL,655 REDWOOD ST,BALTIMORE,MD 21201. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 18 TC 30 Z9 34 U1 0 U2 4 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0014-4894 J9 EXP PARASITOL JI Exp. Parasitol. PD OCT PY 1991 VL 73 IS 3 BP 311 EP 316 DI 10.1016/0014-4894(91)90102-3 PG 6 WC Parasitology SC Parasitology GA GK786 UT WOS:A1991GK78600008 PM 1915745 ER PT J AU YOURICK, JJ CLARK, CR MITCHELTREE, LW AF YOURICK, JJ CLARK, CR MITCHELTREE, LW TI NIACINAMIDE PRETREATMENT REDUCES MICROVESICLE FORMATION IN HAIRLESS GUINEA-PIGS CUTANEOUSLY EXPOSED TO SULFUR MUSTARD SO FUNDAMENTAL AND APPLIED TOXICOLOGY LA English DT Article ID ATHYMIC NUDE-MICE; NORMAL HUMAN-LYMPHOCYTES; HUMAN-SKIN GRAFTS; NAD+ LEVELS; INHIBITORS; TOXICITY; SULFIDE; CELLS; MODEL C1 USA,MED RES INST CHEM DEF,COMPARAT PATHOL BRANCH,ABERDEEN PROVING GROUND,MD 21010. RP YOURICK, JJ (reprint author), USA,MED RES INST CHEM DEF,APPL PHARMACOL BRANCH,SGRDUV-PA,ABERDEEN PROVING GROUND,MD 21010, USA. NR 24 TC 53 Z9 55 U1 0 U2 2 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0272-0590 J9 FUND APPL TOXICOL JI Fundam. Appl. Toxicol. PD OCT PY 1991 VL 17 IS 3 BP 533 EP 542 DI 10.1016/0272-0590(91)90203-G PG 10 WC Toxicology SC Toxicology GA GL283 UT WOS:A1991GL28300010 PM 1838996 ER PT J AU ALLEY, MRK GOMES, SL ALEXANDER, W SHAPIRO, L AF ALLEY, MRK GOMES, SL ALEXANDER, W SHAPIRO, L TI GENETIC-ANALYSIS OF A TEMPORALLY TRANSCRIBED CHEMOTAXIS GENE-CLUSTER IN CAULOBACTER-CRESCENTUS SO GENETICS LA English DT Article ID CLONING VEHICLES; ESCHERICHIA-COLI; PROTEINS; CONSTRUCTION; PLASMID; FUSIONS; SYSTEM; LOCALIZATION; EXPRESSION; SELECTION AB Caulobacter crescentus performs chemotaxis by short intermittent reversals of rotation of its single polar flagellum. Tn5 insertions causing a general chemotaxis phenotype, an inability to reverse swimming direction and to form large swarm colonies, have been mapped to an 8-kb region of the C. crescentus genome. These Tn5 mutations had different effects on the methyl-accepting chemotaxis proteins (MCP), and the activities of methyltransferase and methylesterase. The Tn5 insertion mutant SC1130 had no cross-reacting MCP and had reduced levels of activity of the methyltransferase and methylesterase. Other mutants bearing Tn5 insertions retained cross-reacting MCP activity and were altered only in their methyltransferase and methylesterase activities. Using a cosmid library we isolated a clone that complemented SC1130. Complementation studies of the Tn5 mutants using derivatives of the cosmid clone showed that all the Tn5 insertions lie within a single operon that appears to encode many chemotaxis genes. The first gene in this operon was shown to encode an MCP by immuno-blot analysis of strains carrying beta-galactosidase protein fusions to portions of the operon. The promoter of this operon was located by chromosomal integration of subclones of this region and by identifying DNA fragments that were capable of expressing lacZ transcriptional fusions. The transcription of the che operon occurred at a defined time in the cell cycle, prior to cell division. C1 UNIV SAO PAULO,INST QUIM,DEPT BIOQUIM,BR-01498 SAO PAULO,BRAZIL. WALTER REED ARMY MED CTR,ROCKVILLE,MD 20850. RP ALLEY, MRK (reprint author), STANFORD UNIV,MED CTR,SCH MED,DEPT DEV BIOL,STANFORD,CA 94305, USA. RI Gomes, Suely/D-8938-2012 FU NIGMS NIH HHS [GM32506] NR 34 TC 72 Z9 73 U1 0 U2 0 PU GENETICS PI BALTIMORE PA 428 EAST PRESTON ST, BALTIMORE, MD 21202 SN 0016-6731 J9 GENETICS JI Genetics PD OCT PY 1991 VL 129 IS 2 BP 333 EP 342 PG 10 WC Genetics & Heredity SC Genetics & Heredity GA GH445 UT WOS:A1991GH44500004 PM 1660425 ER PT J AU MITCHELL, D MITCHELL, D DAVIDSON, M VERNALIS, M EDWARDS, F PARK, R BARNHILL, D AF MITCHELL, D MITCHELL, D DAVIDSON, M VERNALIS, M EDWARDS, F PARK, R BARNHILL, D TI NONGENITAL PELVIC LEIOMYOSARCOMA METASTATIC TO THE HEART SO GYNECOLOGIC ONCOLOGY LA English DT Article ID RETROPERITONEUM; SARCOMAS; TUMORS C1 WALTER REED ARMY MED CTR,DEPT OBSTET & GYNECOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,ECHOCARDIOG LAB,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,THORAC SURG SERV,WASHINGTON,DC 20307. RP MITCHELL, D (reprint author), WALTER REED ARMY MED CTR,GYNECOL ONCOL SERV,WASHINGTON,DC 20307, USA. NR 11 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD OCT PY 1991 VL 43 IS 1 BP 84 EP 87 DI 10.1016/0090-8258(91)90015-W PG 4 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA GT023 UT WOS:A1991GT02300014 PM 1959793 ER PT J AU GREEN, M COHEN, D LERMAN, Y SJOGREN, MH BINN, L TUR, S SLEPON, R DANON, Y HOKE, C BANCROFT, WH AF GREEN, M COHEN, D LERMAN, Y SJOGREN, MH BINN, L TUR, S SLEPON, R DANON, Y HOKE, C BANCROFT, WH TI IMMUNOGENICITY OF A HEPATITIS-A VACCINE ADMINISTERED ALONE OR WITH IMMUNE SERUM GLOBULIN SO HEPATOLOGY LA English DT Meeting Abstract C1 ISRAEL DEF FORCES,MED CORPS,JERUSALEM,ISRAEL. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 1991 VL 14 IS 4 BP A94 EP A94 PN 2 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA GK111 UT WOS:A1991GK11100186 ER PT J AU HOKE, CH EGAN, J DEFRAITES, RF HILLS, JC SANCHEZ, J MACARTHY, P SJOGREN, MH DHONDT, E BOSCIA, JA MOONSAMMY, GI BINN, LN BANCROFT, WH AF HOKE, CH EGAN, J DEFRAITES, RF HILLS, JC SANCHEZ, J MACARTHY, P SJOGREN, MH DHONDT, E BOSCIA, JA MOONSAMMY, GI BINN, LN BANCROFT, WH TI IMMUNOGENICITY OF HEPATITIS-A VACCINE WHEN GIVEN WITH HEPATITIS-B VACCINE SO HEPATOLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,FT CAMPBELL,KY. SMITHKLINE BEECHAM,PHILADELPHIA,PA. SMITHKLINE BEECHAM,RIXENSART,BELGIUM. NR 0 TC 1 Z9 1 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 1991 VL 14 IS 4 BP A76 EP A76 PN 2 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA GK111 UT WOS:A1991GK11100114 ER PT J AU MOSES, FM STAMM, CP LARSEN, BL SHAH, RB BREWER, TG AF MOSES, FM STAMM, CP LARSEN, BL SHAH, RB BREWER, TG TI ORAL LOW-DOSE PULSE METHOTREXATE (MTX) IN PRIMARY SCLEROSING CHOLANGITIS (PSC) - AN OPEN LABEL TRIAL SO HEPATOLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,NUCL MED SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,GASTROENTEROL SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. NR 1 TC 1 Z9 1 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 1991 VL 14 IS 4 BP A195 EP A195 PN 2 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA GK111 UT WOS:A1991GK11100588 ER PT J AU SJOGREN, MH PURCELL, RH MCKEE, K BINN, L MACARTHY, P LAKOVIC, M TICEHURST, J HOKE, C FEINSTONE, SM HONDT, ED BANCROFT, WH AF SJOGREN, MH PURCELL, RH MCKEE, K BINN, L MACARTHY, P LAKOVIC, M TICEHURST, J HOKE, C FEINSTONE, SM HONDT, ED BANCROFT, WH TI LIMITED REPLICATIVE CAPACITY OF A LIVE, ATTENUATED HEPATITIS-A VACCINE FOLLOWING ORAL IMMUNIZATION OF VOLUNTEERS SO HEPATOLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NIH,BETHESDA,MD 20892. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. US FDA,BETHESDA,MD 20014. SMITHKLINE BEECHAM,RIXENSART,BELGIUM. RI Ticehurst, John/I-7532-2012 NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 1991 VL 14 IS 4 BP A219 EP A219 PN 2 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA GK111 UT WOS:A1991GK11100684 ER PT J AU CATTELINO, MJ MIRAM, GV SMITH, B AF CATTELINO, MJ MIRAM, GV SMITH, B TI FAST-WARM-UP AND SUPER-FAST-WARM-UP CATHODES USING NOVEL APG APBN HEATERS SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Article AB A novel fast-warm-up heater/cathode approach for microwave tubes is described. Anisotropic pyrolytic graphite (APG) deposited onto anisotropic pyrolytic boron nitride (APBN) is used to fabricate heater wafers. Both planar and spherical heaters can be produced. APG/APBN characteristics are discussed along with methods for heater fabrication. Measured fast-warm-up thermal cycling data are presented for 4- to 60-mm cathode diameters. Fast-warm-up times of 1 to 2 s for 4- to 6.4-mm-diameter cathodes and less than 20 s for 60-mm-diameter cathodes are demonstrated with highly reliable thermal cycling performance. C1 USA,COMMAND LAB,FT MONMOUTH,NJ 07703. RP CATTELINO, MJ (reprint author), VARIAN ASSOCIATES INC,PALO ALTO,CA 94303, USA. NR 6 TC 6 Z9 7 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9383 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD OCT PY 1991 VL 38 IS 10 BP 2239 EP 2243 DI 10.1109/16.88505 PG 5 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA GG470 UT WOS:A1991GG47000008 ER PT J AU EA, JY ZHU, DZ LU, YC LALEVIC, B ZETO, RJ AF EA, JY ZHU, DZ LU, YC LALEVIC, B ZETO, RJ TI SILICON AVALANCHE CATHODES AND THEIR CHARACTERISTICS SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Article ID COLD CATHODES; FIELD-EMISSION AB A highly doped shallow p-n junction (less-than-or-equal-to 300 angstrom) is used to fabricate a Silicon Avalanche Cathode (SAC) to serve as an electron source for a micro-vacuum diode. Single and arrayed SAC's are integrated on the same chip with separate bias configurations. Since the device fabrication is fully compatible with Si IC processing, high repeatability and reliability are achieved. The device structure and a simple series resistance model are described. Anode collection current of approximately 0.7-mu-A is obtained from a single cathode (40-mu-m diameter), and the emission current is multiplied by the number of cathodes for arrayed cathodes. Emission characteristics are investigated as a function of reverse-bias conditions, anode collection voltages, and cathode diameters. The emission efficiency (anode collection current/total bias current) is found to be almost independent of cathode size, however higher anode collection voltages increase the emission efficiency. C1 RUTGERS STATE UNIV,DEPT ELECT & COMP ENGN,PISCATAWAY,NJ 08855. USA,ELECTR TECHNOL & DEVICES,FT MONMOUTH,NJ 07703. NR 14 TC 8 Z9 8 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9383 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD OCT PY 1991 VL 38 IS 10 BP 2377 EP 2382 DI 10.1109/16.88529 PG 6 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA GG470 UT WOS:A1991GG47000032 ER PT J AU HEYDT, GT KISH, DJ HOLCOMB, F HILL, Y AF HEYDT, GT KISH, DJ HOLCOMB, F HILL, Y TI A METHODOLOGY FOR ASSESSMENT OF HARMONIC IMPACT AND COMPLIANCE WITH STANDARDS FOR DISTRIBUTION-SYSTEMS SO IEEE TRANSACTIONS ON POWER DELIVERY LA English DT Article DE HARMONICS; DISTRIBUTION SYSTEMS; STATE ESTIMATION; HARMONICS STANDARDS; HARMONIC IMPEDANCE; EQUIVALENT IMPEDANCE; POWER QUALITY; TOTAL HARMONIC DISTORTION AB Many problems related to harmonic signals in power systems occur at the distribution voltage level. Large commercial, industrial, or institional sites may contain loads whose demand currents are nonsinusoidal. The harmonic content of these load currents may couple with other loads on the same feeder or loads on different feeders energized by the same transformer. The new IEEE Standard 519 specifies maximum harmonic signal levels at points of common coupling to the electric utility. We find these standards to be applicable within industrial and institutional sites. A state estimation methodology is illustrated for the calculation of harmonic current and voltage distortion at all busses in a distribution system. It is recommended to check these distortion levels for compliance with the Standard 519. The paper also gives an interesting calculation of the total harmonic distortion of an ideal converter current. New approximations are also introduced for the bus impedance matrix at frequency h-omega-0. The approximations are developed from power series expansions in either frequency, omega, or inverse complex frequency, (j-omega)-1. The convergence of the series is studied in terms of Banach's lemma. C1 USA,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL. UNIV MICHIGAN,DEPT UTILITIES,ANN ARBOR,MI 48109. RP HEYDT, GT (reprint author), PURDUE UNIV,W LAFAYETTE,IN 47907, USA. NR 6 TC 7 Z9 7 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0885-8977 J9 IEEE T POWER DELIVER JI IEEE Trans. Power Deliv. PD OCT PY 1991 VL 6 IS 4 BP 1748 EP 1754 DI 10.1109/61.97716 PG 7 WC Engineering, Electrical & Electronic SC Engineering GA GK858 UT WOS:A1991GK85800054 ER PT J AU KALTER, DC GENDELMAN, HE MELTZER, MS AF KALTER, DC GENDELMAN, HE MELTZER, MS TI INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION IN MONOCYTES BY MONOCLONAL-ANTIBODIES AGAINST LEUKOCYTE ADHESION MOLECULES SO IMMUNOLOGY LETTERS LA English DT Article; Proceedings Paper CT 3RD MEETING ON INFECTION IMMUNITY : LYMPHOID CELLS AND MOLECULES IN INFECTION IMMUNITY CY MAY 17-21, 1991 CL ELSINORE, DENMARK SP EUROPEAN FEDERAT IMMUNOL SOC, STATENS SERUMINST DE HIV; MONOCYTE; LEUKOCYTE ADHESION MOLECULE; INHIBITION OF INFECTION ID FUNCTION-ASSOCIATED ANTIGEN-1; SYNCYTIUM FORMATION; AIDS RETROVIRUS; BINDING-SITE; ALPHA-CHAIN; CD4+ CELLS; T-CELLS; RECEPTOR; MACROPHAGES; HIV-1 AB CD4 is the surface receptor for HIV envelope. Some evidence exists, however, that other cell surface receptors may be involved in viral entry subsequent to the initial binding of gp120 to CD4. Antibodies to leukocyte integrin LFA-1, a major component of intercellular adhesive interactions, have been shown to inhibit HIV-induced syncytia formation. Using a stringent system for in vitro HIV infection of human leukocytes, we examine the ability of some monoclonal antibodies (mAb) against various adhesion-related molecules to block or partially inhibit productive viral replication. HIV-1 infection of target monocytes or T cells by cell-free virus was blocked completely or partially by some mAb that prevent cell-cell interactions (CD4, HLA-DR, LFA-1, LFA-3), but not by others (ICAM-1, MAC-1, gp150.95, CD2, CD3, CD14). The capacity for mAb to block HIV infection appears to be epitope-specific, and does not relate to the ability to block homotypic adhesion. HIV transmission from infected cells was more difficult to block than was infection by cell-free virus. Adhesion molecules may be involved in facilitating early stages of HIV infection, following gp120/CD4 binding but prior to viral integration, in a manner distinct from cell-cell adhesion. C1 WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,WASHINGTON,DC 20307. HENRY M JACKSON FDN ADVANCEMENT MIL MED,ROCKVILLE,MD. NR 30 TC 35 Z9 35 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-2478 J9 IMMUNOL LETT JI Immunol. Lett. PD OCT PY 1991 VL 30 IS 2 BP 219 EP 228 PG 10 WC Immunology SC Immunology GA GN481 UT WOS:A1991GN48100014 PM 1757107 ER PT J AU PATTON, LL POLLACK, S WELLNER, RB AF PATTON, LL POLLACK, S WELLNER, RB TI RESPONSIVENESS OF A HUMAN PAROTID EPITHELIAL-CELL LINE (HSY) TO AUTONOMIC STIMULATION - MUSCARINIC CONTROL OF K+ TRANSPORT SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY LA English DT Article DE SALIVARY; CELL LINE; MUSCARINIC; CA2+ SIGNAL; K+ TRANSPORT; PROTEIN KINASE-C ID ACTIVATED POTASSIUM CHANNELS; CALCIUM; SECRETION; MOBILIZATION AB Salivary electrolyte secretion is under the control of the autonomic nervous system. In this paper we report that HSY, an epithelial cell line derived from the acinar-intercalated duct region of the human parotid gland, responds to muscarinic-cholinergic (generation of Ca2+ signal) and beta-adrenergic (generation of cAMP signal), but not to alpha-adrenergic (lack of Ca2+ signal), receptor stimulation. The muscarinic response was studied in detail. Carbachol (10(-4) M, muscarinic agonist) or A23187 (5-mu-M, calcium ionophore) stimulation of HSY cells increases both Rb-86 (K+) influx and efflux, resulting in no change in net equilibrium Rb-86 content. Atropine (10(-5) M, muscarinic antagonist) blocks both the carbachol-generated Ca2+ signal and carbachol-stimulated Rb-86 fluxes, but has no effect on either the A23187-generated Ca2+ signal or A23187-stimulated Rb-86 fluxes. Carbachol- and A23187-stimulated Rb-86 fluxes are substantially inhibited by two K+ channel blockers, quinine (0.3 mM) and scorpion venom containing charybdotoxin (33-mu-g/ml). The inhibition of these stimulated fluxes by another K+ channel blocker, tetraethylammonium chloride (5 mM), is less pronounced. Protein kinase C (PKC) seems to be involved in the regulation of the Rb-86 fluxes as 10(-7) M PMA (phorbol ester, phorbol-12-myristate-13-acetate) substantially inhibits the muscarinic-stimulated Rb-86 efflux and influx. Because this concentration of PMA totally inhibits the carbachol-generated Ca2+ signal and only 80% of the muscarinic-stimulated Rb-86 influx, it seems that a portion of the carbachol-stimulated Rb-86 flux (i.e. that portion not inhibited by PMA) might occur independently of the Ca2+ signal. PMA fails to inhibit the A23187-stimulated Rb-86 fluxes, however, suggesting that PKC regulates Ca2+-sensitive K+ channel activity by regulating the Ca2+ signal, and not steps distal to this event. 4-alpha-Phorbol-12,13-didecanoate, a phorbol ester which fails to activate PKC, fails to inhibit either the carbachol-stimulated increase in intracellular free Ca2+, or carbachol-stimulated Rb-86 fluxes. C1 NIDR,CLIN INVEST & PATIENT CARE BRANCH,BETHESDA,MD 20892. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. OI Patton, Lauren/0000-0002-8253-4588 NR 28 TC 11 Z9 11 U1 0 U2 0 PU SOC IN VITRO BIOLOGY PI COLUMBIA PA 8815 CENTRE PARK DRIVE SUITE 210, COLUMBIA, MD 21045 SN 0073-5655 J9 IN VITRO CELL DEV B PD OCT PY 1991 VL 27 IS 10 BP 779 EP 785 PG 7 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA GP874 UT WOS:A1991GP87400007 PM 1960145 ER PT J AU YAMAMOTO, T ENDO, S YOKOTA, T ECHEVERRIA, P AF YAMAMOTO, T ENDO, S YOKOTA, T ECHEVERRIA, P TI CHARACTERISTICS OF ADHERENCE OF ENTEROAGGREGATIVE ESCHERICHIA-COLI TO HUMAN AND ANIMAL MUCOSA SO INFECTION AND IMMUNITY LA English DT Article ID HUMAN SMALL-INTESTINE; VIBRIO-CHOLERAE O1; LYMPHOID FOLLICLE EPITHELIUM; PLASMID-MEDIATED FACTORS; HUMAN URETERAL MUCOSA; PERSISTENT DIARRHEA; COLONIZATION FACTOR; INVITRO ADHERENCE; PEYERS PATCHES; HEP-2 CELLS AB An Escherichia coli strain (serotype O127a:H2) that had been isolated from a child with diarrhea in Thailand and that was negative for the virulence factors of the four categories of diarrheagenic E. coli (enterotoxigenic, enteropathogenic, enteroinvasive, and enterohemorrhagic) and that showed an aggregative pattern of adherence to HeLa cells was investigated for adherence to native or Formalin-fixed human and animal mucosa. The hemagglutinating activity and adherence ability of the bacteria were resistant to D-mannose and were strictly regulated by environmental conditions. Genetic data supported the close relation between the hemagglutinating activity and adherence ability. In accordance with the adherence pattern on tissue-cultured cells, the bacteria adhered to human and animal mucosa, as evidenced by a direct gold-labeling analysis. In human intestines, Formalin-fixed mucous coatings, epithelial cells of colonic mucosa, epithelial cells of ileal single lymphoid follicles and Peyer's patches, and the absorptive cells of jejunal or ileal villi provided adherence targets. Adherence to M cells in the Peyer's patch-associated epithelium was also confirmed. The adherence levels to native jejunal or ileal human villi were low, as was the case with the corresponding Formalin-fixed villi. In human urinary tract, the superficial epithelial cells of both native and Formalin-fixed ureter provided striking adherence targets. In animal (procine and rabbit) small intestines, the bacteria adhered to the native villi to a lesser extent than to the Formalin-fixed villi. The adherence levels were compared with those of enterotoxigenic E. coli with colonization factor antigen (CFA)/I pili or CFA/II pili. The data suggested unique mucosa adherence characteristics of the enteroaggregative E. coli strain. The possibility of the adherence ability as a virulence factor was discussed. C1 ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. RP YAMAMOTO, T (reprint author), JUNTENDO UNIV,SCH MED,DEPT BACTERIOL,2-1-1 HONGO,BUNKYO KU,TOKYO 113,JAPAN. NR 42 TC 67 Z9 69 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD OCT PY 1991 VL 59 IS 10 BP 3722 EP 3739 PG 18 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA GH076 UT WOS:A1991GH07600055 PM 1680107 ER PT J AU TESSLER, A AF TESSLER, A TI A 2-NODE BEAM ELEMENT INCLUDING TRANSVERSE-SHEAR AND TRANSVERSE NORMAL DEFORMATIONS SO INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING LA English DT Article AB A variational higher-order theory for bending and stretching of linearly elastic orthotropic beams including the deformations due to transverse shearing and stretching of the transverse normal fibre is presented. The theory assumes a linear distribution for the longitudinal displacement and a parabolic variation of the transverse displacement across the thickness. Additionally, independent expansions are introduced for the through-thickness displacement gradients with the requirement of a least-square compatibility for the transverse strains and the satisfaction of exact stress boundary conditions at the top/bottom beam surfaces. The theory is shown to be well suited for finite element development requiring simple C0- and C-1- continuous displacement interpolation fields. To demonstrate the computational utility of the theory, a simple two-node stretching-bending finite element is formulated. The analytic and finite element results are obtained for a simple bending problem for which an exact elasticity solution is available. It is shown that the inclusion of the transverse normal deformation in the present theory enables improved displacement, strain and stress predictions, particularly, in the analysis of deep beams. RP TESSLER, A (reprint author), USA,MAT TECHNOL LAB,MECH & STRUCT BRANCH,WATERTOWN,MA 02172, USA. RI Tessler, Alexander/A-4729-2009 NR 14 TC 6 Z9 7 U1 0 U2 1 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0029-5981 J9 INT J NUMER METH ENG JI Int. J. Numer. Methods Eng. PD OCT PY 1991 VL 32 IS 5 BP 1027 EP 1039 DI 10.1002/nme.1620320507 PG 13 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Mathematics GA GH040 UT WOS:A1991GH04000006 ER PT J AU SHELTON, RM AF SHELTON, RM TI ALOE VERA - ITS CHEMICAL AND THERAPEUTIC PROPERTIES SO INTERNATIONAL JOURNAL OF DERMATOLOGY LA English DT Review ID ANTI-INFLAMMATORY ACTIVITY; CONTACT-DERMATITIS; ARBORESCENS; FROSTBITE; INJURIES; WOUNDS; GEL RP SHELTON, RM (reprint author), BROOKE ARMY MED CTR,DEPT DERMATOL,FT SAM HOUSTON,TX 78234, USA. NR 63 TC 87 Z9 98 U1 4 U2 15 PU DECKER PERIODICALS INC PI HAMILTON PA 4 HUGHSON STREET SOUTH PO BOX 620, LCD 1, HAMILTON ON L8N 3K7, CANADA SN 0011-9059 J9 INT J DERMATOL JI Int. J. Dermatol. PD OCT PY 1991 VL 30 IS 10 BP 679 EP 683 DI 10.1111/j.1365-4362.1991.tb02607.x PG 5 WC Dermatology SC Dermatology GA GL401 UT WOS:A1991GL40100001 PM 1823544 ER PT J AU GRIMSLEY, JK MASTERS, CI CLARK, EP MINTON, KW AF GRIMSLEY, JK MASTERS, CI CLARK, EP MINTON, KW TI ANALYSIS BY PULSED-FIELD GEL-ELECTROPHORESIS OF DNA DOUBLE-STRAND BREAKAGE AND REPAIR IN DEINOCOCCUS-RADIODURANS AND A RADIOSENSITIVE MUTANT SO INTERNATIONAL JOURNAL OF RADIATION BIOLOGY LA English DT Article ID MICROCOCCUS-RADIODURANS; DUPLICATION INSERTION; GENOME; CELL AB Double-strand break (dsb) induction and rejoining after ionizing radiation was analysed in Deinococcus radiodurans and a radiosensitive mutant by pulsed-field gel electrophoresis. Following 2 kGy, migration of genomic DNA (not restriction cleaved) from the plug into the gel was extensive, but was not observed after 90 min postirradiation recovery. By this time D. radiodurans chromosomes were intact, as demonstrated by restoration of the Not I restriction cleavage pattern of 11 bands, which we found to be the characteristic pattern in unirradiated cells. Following the higher exposure of 4 kGy, dsb rejoining took approximately 180 min, twice as long as required following the 2 kGy exposure. Restoration of dsb in the radiosensitive mutant strain 112, which appears to be defective in recombination, was markedly retarded at both 2 and 4 kGy. The Not I restriction fragments of wild-type D. radiodurans and the radiosensitive mutant were identical, totaling 3.58 Mbp, equivalent to 2.36 x 10(9) daltons per chromosome. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PATHOL,BETHESDA,MD 20814. USA,RADIOBIOL RES INST,DEPT RADIAT BIOCHEM,BETHESDA,MD 20814. FU NIGMS NIH HHS [GM39933] NR 22 TC 32 Z9 36 U1 0 U2 3 PU TAYLOR & FRANCIS LTD PI LONDON PA ONE GUNDPOWDER SQUARE, LONDON, ENGLAND EC4A 3DE SN 0955-3002 J9 INT J RADIAT BIOL JI Int. J. Radiat. Biol. PD OCT PY 1991 VL 60 IS 4 BP 613 EP 626 DI 10.1080/09553009114552441 PG 14 WC Biology; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Life Sciences & Biomedicine - Other Topics; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA GG464 UT WOS:A1991GG46400003 PM 1680142 ER PT J AU CAWTHON, MA GOERINGER, F TELEPAK, RJ BURTON, BS PUPA, SH WILLIS, CE HANSEN, MF AF CAWTHON, MA GOERINGER, F TELEPAK, RJ BURTON, BS PUPA, SH WILLIS, CE HANSEN, MF TI PRELIMINARY ASSESSMENT OF COMPUTED-TOMOGRAPHY AND SATELLITE TELERADIOLOGY FROM OPERATION DESERT STORM SO INVESTIGATIVE RADIOLOGY LA English DT Article DE COMPUTED TOMOGRAPHY; SATELLITE TELERADIOLOGY; DESERT STORM, OPERATION AB Computed tomography at military transportable hospitals was used for the first time during the recent Operation Desert Storm in the Saudi Arabian desert. Scan quality was excellent and the scans proved clinically important in patient management. A teleradiology link via satellite to the U.S. mainland was also successfully employed. The objectives of the teleradiology link were to validate the concept distant interpretation of images obtained on the battlefield and to provide specialty radiology consultation. This technology shows great promise for future applications, both for combat casualty care and for civilian disaster medical support operations. C1 USDA,OFF SURGEON GEN,DIV LOGIST,FALLS CHURCH,VA. FITZSIMONS ARMY MED CTR,DEPT RADIOL,AURORA,CO 80045. TRIPLER ARMY MED CTR,DEPT RADIOL,HONOLULU,HI 96859. RP CAWTHON, MA (reprint author), BROOKE ARMY MED CTR,DEPT RADIOL,SAN ANTONIO,TX 78234, USA. RI Pupa, Serenella/K-6388-2016 OI Pupa, Serenella/0000-0002-4592-6830 NR 5 TC 13 Z9 13 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0020-9996 J9 INVEST RADIOL JI Invest. Radiol. PD OCT PY 1991 VL 26 IS 10 BP 854 EP 857 DI 10.1097/00004424-199110000-00002 PG 4 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA GK705 UT WOS:A1991GK70500002 PM 1960024 ER PT J AU MEYERS, MA LASALVIA, JC MEYER, LW HOKE, D NIILER, A AF MEYERS, MA LASALVIA, JC MEYER, LW HOKE, D NIILER, A TI REACTION SYNTHESIS DYNAMIC COMPACTION OF TITANIUM CARBIDE AND TITANIUM DIBORIDE SO JOURNAL DE PHYSIQUE III LA English DT Article; Proceedings Paper CT 3RD INTERNATIONAL CONF ON MECHANICAL AND PHYSICAL BEHAVIOUR OF MATERIALS UNDER DYNAMIC LOADING ( DYMAT 91 ) CY OCT 14-18, 1991 CL STRASBOURG, FRANCE SP MINIST DEF FRANCE, MINIST RECH & TECHNOL FRANCE, MINIST AFFAIRES ETRANGERES FRANCE, DELEGAT GEN ARMEMENT, CNRS, CEA AB Titanium carbide and titanium diboride were synthesized by self-propagating combustion reactions and densified by a high-speed forging technique, in which a hammer strikes the hot and porous ceramic (T approximately 2000-degrees-C) at velocities in the range 5 - 15 m/s. Compacts with densities higher than 96% of the theoretical density and diameters close to 10 cm were produced by this method. Optical and scanning electron microscopy of the consolidated material were carried out, revealing a grain size of approximately 44-mu-m for TiC and 15-mu-m for TiB2; these grains were equiaxed, indicating that crystallization (or recrystallization) occurred after the densification process. The quasistatic and dynamic compressive strengths were established and compared to those of hot-pressed material produced by CERCOM. For TiB2, the strengths were approximately 1.8 GPa, while for TiC the quasistatic (10(-3) s-1) and dynamic (10(2) s-1) strengths were 1.7 and 2.2 GPa, respectively. C1 FRAUNHOFER INST ANGEW MAT FORSCH,BREMEN,GERMANY. USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005. RP MEYERS, MA (reprint author), UNIV CALIF SAN DIEGO,DEPT APPL MECH & ENGN SCI,LA JOLLA,CA 92093, USA. RI Meyers, Marc/A-2970-2016 OI Meyers, Marc/0000-0003-1698-5396 NR 4 TC 2 Z9 2 U1 0 U2 1 PU EDITIONS PHYSIQUE PI LES ULIS CEDEX PA Z I DE COURTABOEUF AVE 7 AV DU HOGGAR, BP 112, 91944 LES ULIS CEDEX, FRANCE SN 1155-4339 J9 J PHYS IV JI J. Phys. IV PD OCT PY 1991 VL 1 IS C3 BP 123 EP 130 DI 10.1051/jp4:1991316 PG 8 WC Physics, Multidisciplinary SC Physics GA GG302 UT WOS:A1991GG30200017 ER PT J AU HUANG, SY TAWNEY, KW BENDER, PR GROVES, BM MCCULLOUGH, RE MCCULLOUGH, RG MICCO, AJ MANCOJOHNSON, M CYMERMAN, A GREENE, ER REEVES, JT AF HUANG, SY TAWNEY, KW BENDER, PR GROVES, BM MCCULLOUGH, RE MCCULLOUGH, RG MICCO, AJ MANCOJOHNSON, M CYMERMAN, A GREENE, ER REEVES, JT TI INTERNAL CAROTID FLOW VELOCITY WITH EXERCISE BEFORE AND AFTER ACCLIMATIZATION TO 4,300-M SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE CEREBRAL BLOOD FLOW; OXYGEN DELIVERY; HYPOXIA; BLOOD GASES; DOPPLER ULTRASOUND ID CEREBRAL BLOOD-FLOW; HIGH-ALTITUDE; ULTRASOUND AB Cerebral blood flow and O2 delivery during exercise are important for well-being at altitude but have not been studied. We expected flow to increase on arrival at altitude and then to fall as O2 saturation and hemoglobin increased, thereby maintaining cerebral O2 delivery. We used Doppler ultrasound to measure internal carotid artery flow velocity at sea level and on Pikes Peak, CO (4,300 m). In an initial study (1987, n = 7 men) done to determine the effect of brief (5-min) exercises of increasing intensity, we found at sea level that velocity [28.4 +/- 1.4 (SE) cm/s rest] increased by 15 +/- 7, 30 +/- 6, and 22 +/- 8% for cycle exercises at 33, 71, and 96% of maximal O2 uptake, respectively. During acute hypobaric hypoxia in a decompression chamber (inspired PO2 = 83 Torr), velocity (23.2 +/- 1.4 cm/s rest) increased by 33 +/- 6, 20 +/- 5, and 17 +/- 9% for exercises at 45, 72, and 98% of maximal O2 uptake, respectively. After 18 days on Pikes Peak (inspired PO2 = 87 Torr), velocity (26.6 +/- 1.5 cm/s rest) did not increase with exercise. A subsequent study (1988, n = 7 men) of the effect of prolonged exercise (45 min at approximately 100 W) found at sea level that velocity (24.8 +/- 1.7 cm/s rest) increased by 22 +/- 6, 13 +/- 5, 17 +/- 4, and 12 +/- 3% at 5, 15, 30, and 45 min. The increase above rest (24.3 +/- 1.1 cm/s) had a pattern suggesting a lesser response on arrival on Pikes Peak and was not significant after 21 days of residence (25.9 +/- 1.6 cm/s rest to 26.9 +/- 1.9 cm/s exercise). Internal carotid arterial diameters did not change with exercise or altitude exposure. Compared with sea level, the reduced O2 content on arrival and the absence of a sustained increase in exercise flow resulted in cerebral O2 delivery not being maintained during exercise. With acclimatization, the improved content returned O2 delivery toward sea level values. C1 UNIV COLORADO,HLTH SCI CTR,DEPT RADIOL ULTRASOUND,DENVER,CO 80262. USA,INST ENVIRONM MED,NATICK,MA 01760. LOVELACE FDN MED EDUC & RES,BIOMED RES DIV,ALBUQUERQUE,NM 87108. SHANGHAI INST PHYSIOL,SHANGHAI,PEOPLES R CHINA. RP HUANG, SY (reprint author), UNIV COLORADO,HLTH SCI CTR,DEPT ANESTHESIOL B113,DIV CARDIOL,CARDIOVASC PULM LAB,DENVER,CO 80262, USA. FU NHLBI NIH HHS [HL-14985] NR 26 TC 35 Z9 37 U1 1 U2 4 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD OCT PY 1991 VL 71 IS 4 BP 1469 EP 1476 PG 8 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA GJ961 UT WOS:A1991GJ96100040 PM 1757372 ER PT J AU BHADURI, S TURNERJONES, C LACHICA, RV AF BHADURI, S TURNERJONES, C LACHICA, RV TI CONVENIENT AGAROSE MEDIUM FOR SIMULTANEOUS DETERMINATION OF THE LOW-CALCIUM RESPONSE AND CONGO RED BINDING BY VIRULENT-STRAINS OF YERSINIA-ENTEROCOLITICA SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Note ID PLASMID-BEARING CLONES; ASSAY AB A simple, efficient method for identification and differentiation of Yersinia enterocolitica containing virulent plasmid-bearing clones is described. The method is based on temperature of incubation and the low calcium response of the organism in an agarose Congo red medium. C1 USA,NATICK RES,CTR DEV & ENGN,NATICK,MA 01760. RP BHADURI, S (reprint author), USDA ARS,EASTERN REG RES CTR,600 E MERMAID LANE,PHILADELPHIA,PA 19118, USA. NR 16 TC 39 Z9 39 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD OCT PY 1991 VL 29 IS 10 BP 2341 EP 2344 PG 4 WC Microbiology SC Microbiology GA GG963 UT WOS:A1991GG96300049 PM 1939595 ER PT J AU MCCANN, UD RICAURTE, GA AF MCCANN, UD RICAURTE, GA TI LASTING NEUROPSYCHIATRIC SEQUELAE OF (+/-)METHYLENEDIOXYMETHAMPHETAMINE (ECSTASY) IN RECREATIONAL USERS SO JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY LA English DT Note ID CENTRAL SEROTONERGIC NEURONS; RAT-BRAIN; MDMA; NEUROTOXICITY; 3,4-METHYLENEDIOXYMETHAMPHETAMINE; METHYLENEDIOXYMETHAMPHETAMINE; TERMINALS; MDA AB Two persons are described who demonstrated prolonged neuropsychiatric syndromes after the ingestion of large doses of (+/-)-3,4-methylenedioxymethamphetamine (MDMA), a recreationally used amphetamine analog. These cases suggest that MDMA, known to be neurotoxic to serotonin neurons in several experimental animals, may also produce untoward effects in humans. In addition, they provide evidence that ingestion of large doses of MDMA can produce lasting adverse functional consequences in vulnerable persons. C1 JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL,BALTIMORE,MD 21205. RP MCCANN, UD (reprint author), WALTER REED ARMY MED CTR,DEPT BEHAV BIOL,WASHINGTON,DC 20307, USA. NR 24 TC 107 Z9 108 U1 0 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0271-0749 J9 J CLIN PSYCHOPHARM JI J. Clin. Psychopharmacol. PD OCT PY 1991 VL 11 IS 5 BP 302 EP 305 PG 4 WC Pharmacology & Pharmacy; Psychiatry SC Pharmacology & Pharmacy; Psychiatry GA GG423 UT WOS:A1991GG42300005 PM 1684975 ER PT J AU FARLEY, GL AF FARLEY, GL TI THE EFFECTS OF CRUSHING SPEED ON THE ENERGY-ABSORPTION CAPABILITY OF COMPOSITE TUBES SO JOURNAL OF COMPOSITE MATERIALS LA English DT Article AB The energy-absorption capability as a function of crushing speed was determined for Thornel 300-Fiberite 934 (Gr-E) and Kevlar-49-Fiberite 934 (K-E) composite material. Circular cross section tube specimens were crushed at speeds ranging from 0.01 m/sec to 12 m/sec. Ply orientations of the tube specimens were [0/ +/- THETA]2 and [+/- THETA]2 where THETA = 15, 45, and 75 degrees. Based upon the results of these tests the energy-absorption capability of Gr-E and K-E was determined to be a function of crushing speed. The magnitude of the effects of crushing speed on energy-absorption capability was determined to be a function of the mechanisms that control the crushing process. The effects of crushing speed on the energy-absorption capability is related to whether the mechanical response of the crushing mechanism that controls the crushing process is a function of strain rate. Energy-absorption capability of Gr-E and K-E tubes ranged between 0 and 35 percent and 20 and 45 percent, respectively depending upon ply orientation. The crushing modes based upon exterior appearance of the crushed tubes were unchanged as a result of changing crushing speed for either material. However, the interlaminar crushing behavior of the Gr-E specimens changed with crushing speed. RP FARLEY, GL (reprint author), USA,NASA,LANGLEY RES CTR,AVIAT RES & TECHNOL ACT,AEROSTRUCT & DIRECTORATE,HAMPTON,VA 23665, USA. NR 26 TC 65 Z9 66 U1 1 U2 6 PU TECHNOMIC PUBL CO INC PI LANCASTER PA 851 NEW HOLLAND AVE, BOX 3535, LANCASTER, PA 17604 SN 0021-9983 J9 J COMPOS MATER JI J. Compos Mater. PD OCT PY 1991 VL 25 IS 10 BP 1314 EP 1329 PG 16 WC Materials Science, Composites SC Materials Science GA GQ859 UT WOS:A1991GQ85900004 ER PT J AU SCHAUDIES, RP GRIMES, J DAVIS, D KOLDOVSKY, O AF SCHAUDIES, RP GRIMES, J DAVIS, D KOLDOVSKY, O TI MODULATION OF IMMUNOREACTIVE EPIDERMAL GROWTH-FACTOR LEVELS IN THE SUBMANDIBULAR-GLAND, PANCREAS, LIVER, KIDNEY AND GASTROINTESTINAL-TRACT OF SUCKLING RATS BY CORTISONE AND TRIIODOTHYRONINE SO JOURNAL OF ENDOCRINOLOGY LA English DT Article ID NEONATAL MOUSE URINE; DEVELOPMENTAL ASPECTS; THYROXINE; SKIN; EGF; TRIIODOTHYRONINE; TISSUE; MICE AB Suckling rats exhibit age-dependent differences in epidermal growth factor (EGF) levels in several organs. The present studies evaluated the effects of two hormones known for their maturative effect on suckling rats, cortisone and tri-iodothyronine (T3), on immunoreactive EGF levels in specific organs. Suckling rats were administered cortisone (5 mg/100 g body weight per day) or T3 (50-mu-/100 g body weight per day) on days 8, 9, 10 and 11 after birth, and killed on day 12. Submandibular glands, kidneys, pancreas, liver and gastrointestinal tract mucosa and lumen were assayed for immunoreactive EGF by a species-specific radioimmunoassay. Low levels of EGF in the submandibular glands were increased slightly by both T3 and cortisone treatment. Cortisone evoked a tenfold increase in EGF in the pancreas, but had no effect on levels in the kidney or liver. In contrast, T3 evoked a sixfold increase in the EGF level in the kidney, but had no effect on levels in the pancreas or liver. Hormonal administration had no effect on EGF levels in the stomach. Within the intestinal tract, cortisone had no effect on the luminal EGF content of the duodenum, jejunum or ileum, but caused a decrease in the midjejunum. T3 evoked a decrease in the luminal EGF content of the ileum. The effect of cortisone on mucosal EGF content varied between regions; an increase was seen in the duodenum with a decrease in the midjejunum and ileum. T3 administration resulted in a significant decrease in EGF only in the mucosa of the ileum. The EGF-degradative capacity of the luminal contents of the jejunum and ileum, as studied in vitro, were increased by treatment with both T3 and cortisone. However, no direct correlation was observed between alterations of the EGF content in the lumen or mucosa and the increased degradative capacity. We therefore conclude that modulation of EGF levels within the intestine cannot be explained exclusively by alterations in the degradation rates. The results indicate that both adrenal and thyroid glands may play an important role in the modulation of EGF levels in the developing rat. C1 UNIV ARIZONA,DEPT PHYSIOL,TUCSON,AZ 85724. UNIV ARIZONA,CHILDREN RES CTR,TUCSON,AZ 85724. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. UNIV ARIZONA,DEPT PEDIAT,NEONATAL & NUTR SCI SECT,TUCSON,AZ 85724. NR 25 TC 10 Z9 10 U1 0 U2 1 PU J ENDOCRINOLOGY LTD PI BRISTOL PA 17/18 THE COURTYARD, WOODLANDS, ALMONDSBURY, BRISTOL, ENGLAND BS12 4NQ SN 0022-0795 J9 J ENDOCRINOL JI J. Endocrinol. PD OCT PY 1991 VL 131 IS 1 BP 95 EP 100 DI 10.1677/joe.0.1310095 PG 6 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA GM251 UT WOS:A1991GM25100012 PM 1744563 ER PT J AU WELLER, RN JURCAK, JJ DONLEY, DL KULILD, JC AF WELLER, RN JURCAK, JJ DONLEY, DL KULILD, JC TI A NEW MODEL SYSTEM FOR MEASURING INTRACANAL TEMPERATURES SO JOURNAL OF ENDODONTICS LA English DT Article ID ROOT-CANAL OBTURATION; COMPACTION TECHNIQUE; SURFACE AB A new model system was developed which allows intracanal temperature measurements to be recorded during repeated obturations of a human tooth root canal. A human central incisor was embedded in clear orthodontic resin and sectioned longitudinally. Sixteen thermocouples were secured at 2-mm intervals along two surfaces of the root canal. The thermocouples were connected to a computerized temperature recording system to measure intracanal temperatures produced by high-temperature thermoplasticized injectable gutta-percha. The system was capable of recording 16 simultaneous temperatures every second with an accuracy of a hundredth degree centigrade. There was a linear increase in the recorded temperatures in the root canal. However, the actual temperatures were lower than expected. C1 USA,DENT ACTIV,ENDODONT RESDENCY PROGRAM,FT GORDON,GA 30905. NR 6 TC 14 Z9 14 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD OCT PY 1991 VL 17 IS 10 BP 491 EP 494 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA GJ193 UT WOS:A1991GJ19300004 PM 1812193 ER PT J AU WONG, M AF WONG, M TI SURGICAL FENESTRATION OF LARGE PERIAPICAL LESIONS SO JOURNAL OF ENDODONTICS LA English DT Article ID DECOMPRESSION AB The decompression technique utilizing tubing for the treatment of large periapical lesions has been widely used with success. However, unobtainable biopsies and patient noncompliance are among the disadvantages that are of concern. An alternative approach is presented, whereby a surgical procedure is performed involving only partial removal of tissue from the lesion. The advantages of this procedure are discussed. RP WONG, M (reprint author), USA,DENT ACTIV,FT HOOD,TX, USA. NR 9 TC 6 Z9 6 U1 2 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD OCT PY 1991 VL 17 IS 10 BP 516 EP 521 PG 6 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA GJ193 UT WOS:A1991GJ19300010 PM 1812199 ER PT J AU CALKINS, DJ AF CALKINS, DJ TI MINIMIZATION OF FRAZIL-ICE PRODUCTION BY RIVER-FLOW REGULATION - DISCUSSION SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Discussion RP CALKINS, DJ (reprint author), USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD OCT PY 1991 VL 117 IS 10 BP 1402 EP 1405 DI 10.1061/(ASCE)0733-9429(1991)117:10(1402) PG 4 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA GF751 UT WOS:A1991GF75100013 ER PT J AU FERRICK, MG AF FERRICK, MG TI MINIMIZATION OF FRAZIL-ICE PRODUCTION BY RIVER-FLOW REGULATION - DISCUSSION SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Discussion RP FERRICK, MG (reprint author), USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD OCT PY 1991 VL 117 IS 10 BP 1406 EP 1409 DI 10.1061/(ASCE)0733-9429(1991)117:10(1406) PG 4 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA GF751 UT WOS:A1991GF75100014 ER PT J AU MORRILL, JC CZARNIECKI, CW PETERS, CJ AF MORRILL, JC CZARNIECKI, CW PETERS, CJ TI RECOMBINANT HUMAN INTERFERON-GAMMA MODULATES RIFT-VALLEY FEVER VIRUS-INFECTION IN THE RHESUS-MONKEY SO JOURNAL OF INTERFERON RESEARCH LA English DT Article ID HUMAN ALPHA-INTERFERON; ESCHERICHIA-COLI; ANTICELLULAR ACTIVITIES; CIRCULATING INTERFERON; HUIFN-GAMMA; BETA; POTENTIATION; PATHOGENESIS; RABBITS AB Prophylactic treatment of rhesus macaques with 10(4)-10(6) U/kg of recombinant human interferon-gamma (rHuIFN-gamma) modulated Rift Valley fever (RVF) virus infection. IFN was given intramuscularly at 24 h prior to infection and daily thereafter for a total of five doses. After infection, treated monkeys showed no evidence of clinical disease; some had no detectable viremia; when viremia was observed, peak virus titers were decreased compared to control infected monkeys; and only minor and transient perturbations in hematologic and clinical chemistry values were seen. Untreated infected control monkeys developed high-titered viremia, mild to severe clinical disease, and moderate to severe changes in hemostatic parameters and clinical laboratory measurements. No evidence of synergism was noted when RVF virus-infected monkeys were treated prophylactically with combined low doses of rHuIFN-gamma and rHuIFN-alpha-A. RP MORRILL, JC (reprint author), USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,BLDG 1425,FT DETRICK,FREDERICK,MD 21702, USA. NR 31 TC 19 Z9 21 U1 0 U2 3 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0197-8357 J9 J INTERFERON RES JI J. Interferon Res. PD OCT PY 1991 VL 11 IS 5 BP 297 EP 304 DI 10.1089/jir.1991.11.297 PG 8 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA GL982 UT WOS:A1991GL98200008 PM 1774469 ER PT J AU CORCORAN, KD THOEN, CO AF CORCORAN, KD THOEN, CO TI APPLICATION OF AN ENZYME-IMMUNOASSAY FOR DETECTING ANTIBODIES IN SERA OF MACACA-FASCICULARIS NATURALLY EXPOSED TO MYCOBACTERIUM-TUBERCULOSIS SO JOURNAL OF MEDICAL PRIMATOLOGY LA English DT Article DE TUBERCULOSIS; NONHUMAN PRIMATES; ENZYME IMMUNOASSAY ID BOVIS; COMPONENTS AB An enzyme immunoassay (EIA) was developed for detecting mycobacterial antibodies in the sera of 22 Macaca fascicularis following a natural outbreak of tuberculosis. EIAs were conducted using four antigens (lysozyme, triton, or deoxycholate extracts of Mycobacterium tuberculosis or a purified protein derivative) and two conjugates (protein A or antihuman). Mycobacterial antibodies were detected in two of two culture-positive monkeys, in nine of ten tuberculin test-suspect monkeys (culture-negative), and in five of ten tuberculin test-negative monkeys (culture-negative). Results indicate EIA may be of practical value in detecting monkeys exposed to M. tuberculosis. C1 IOWA STATE UNIV SCI & TECHNOL,COLL VET MED,AMES,IA 50011. RP CORCORAN, KD (reprint author), USA,MED RES INST CHEM DEF,DIV VET MED & LAB RESOURCES,ABERDEEN PROVING GROUND,MD 21010, USA. NR 13 TC 6 Z9 7 U1 0 U2 0 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0047-2565 J9 J MED PRIMATOL JI J. Med. Primatol. PD OCT PY 1991 VL 20 IS 8 BP 404 EP 408 PG 5 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA HD571 UT WOS:A1991HD57100006 PM 1803012 ER PT J AU TRASK, DF AF TRASK, DF TI THE SPANISH-AMERICAN WAR - AN ANNOTATED-BIBLIOGRAPHY - VENZON,AC SO JOURNAL OF MILITARY HISTORY LA English DT Book Review RP TRASK, DF (reprint author), US ARMY CTR MIL HISTORY,WASHINGTON,DC, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU VIRGINIA MILITARY INST PI LEXINGTON PA LEXINGTON, VA 24450 SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 1991 VL 55 IS 4 BP 542 EP 543 DI 10.2307/1985778 PG 2 WC History SC History GA GK010 UT WOS:A1991GK01000016 ER PT J AU COFFMAN, EM AF COFFMAN, EM TI A SOLDIER-IS-ALSO-A-CITIZEN - THE CONTROVERSY OVER MILITARY-JUSTICE, 1917-1920 - LINDLEY,JM SO JOURNAL OF MILITARY HISTORY LA English DT Book Review RP COFFMAN, EM (reprint author), US ARMY COMMAND & GENERAL STAFF COLL,FT LEAVENWORTH,KS 66027, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU VIRGINIA MILITARY INST PI LEXINGTON PA LEXINGTON, VA 24450 SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 1991 VL 55 IS 4 BP 544 EP 545 DI 10.2307/1985780 PG 2 WC History SC History GA GK010 UT WOS:A1991GK01000018 ER PT J AU SPILLER, RJ AF SPILLER, RJ TI FULLER,J.F.C. - MILITARY THINKER - REID,BH SO JOURNAL OF MILITARY HISTORY LA English DT Book Review RP SPILLER, RJ (reprint author), US ARMY COMMAND & GENERAL STAFF COLL,FT LEAVENWORTH,KS 66027, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU VIRGINIA MILITARY INST PI LEXINGTON PA LEXINGTON, VA 24450 SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 1991 VL 55 IS 4 BP 547 EP 549 DI 10.2307/1985782 PG 3 WC History SC History GA GK010 UT WOS:A1991GK01000020 ER PT J AU CAMPBELL, D AF CAMPBELL, D TI AMERICAN WOMEN AND WORLD-WAR-II - WEATHERFORD,D SO JOURNAL OF MILITARY HISTORY LA English DT Book Review RP CAMPBELL, D (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU VIRGINIA MILITARY INST PI LEXINGTON PA LEXINGTON, VA 24450 SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 1991 VL 55 IS 4 BP 553 EP 554 DI 10.2307/1985786 PG 2 WC History SC History GA GK010 UT WOS:A1991GK01000024 ER PT J AU SWIK, W BROWDER, DA AF SWIK, W BROWDER, DA TI RECENT JOURNAL ARTICLES + MILITARY HISTORY SO JOURNAL OF MILITARY HISTORY LA English DT Bibliography C1 US MIL ACAD,DEPT HIST,W POINT,NY 10996. RP SWIK, W (reprint author), US MIL ACAD,LIBRARY,W POINT,NY 10996, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU VIRGINIA MILITARY INST PI LEXINGTON PA LEXINGTON, VA 24450 SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 1991 VL 55 IS 4 BP 560 EP 592 PG 33 WC History SC History GA GK010 UT WOS:A1991GK01000029 ER PT J AU PEACOCK, ME BRENNAN, WA STRONG, SL PRIOR, RF ONEAL, RB VANDYKE, TE AF PEACOCK, ME BRENNAN, WA STRONG, SL PRIOR, RF ONEAL, RB VANDYKE, TE TI ANGIOEDEMA AS A COMPLICATION IN PERIODONTAL SURGERY - REPORT OF A CASE SO JOURNAL OF PERIODONTOLOGY LA English DT Article DE ANGIOEDEMA ETIOLOGY; ANGIOTENSION-CONVERTING ENZYME ADVERSE EFFECTS ID HEREDITARY ANGIOEDEMA; URTICARIA; INHIBITOR AB ANGIOEDEMA IS A DIFFUSE SwELLING of the subcutaneous or submucosal tissues that occurs in both hereditary and non-hereditary forms. It can be a temporarily disfiguring condition, but not usually a serious one unless the airway is compromised. In the majority of cases, no underlying cause can be identified. In this report, a case of "idiopathic" angioedema that occurred while performing a periodontal surgical procedure is presented. This case is interesting because the patient was on long-term use of an angiotensin-converting enzyme [ACE] inhibitor for hypertension, and recent evidence has shown that ACE inhibitors suppress the breakdown of circulating bradykinins. With high plasma levels of bradykinins, a local anesthetic, periodontal surgical procedures, or even emotional stress may trigger an attack of angioedema. Practitioners should be aware of the pharmacologic side effects of ACE inhibitors and be prepared to handle an emergency if a patient's airway becomes compromised. C1 EASTMAN DENT CTR,ROCHESTER,NY 14620. RP PEACOCK, ME (reprint author), USA,DENT ACT,PERIODONTAL RESIDENCY PROGRAM,FT GORDON,GA 30905, USA. NR 17 TC 17 Z9 17 U1 0 U2 0 PU AMER ACAD PERIODONTOLOGY PI CHICAGO PA 737 NORTH MICHIGAN AVENUE, SUITE 800, CHICAGO, IL 60611-2690 SN 0022-3492 J9 J PERIODONTOL JI J. Periodont. PD OCT PY 1991 VL 62 IS 10 BP 643 EP 645 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA GK464 UT WOS:A1991GK46400009 PM 1770424 ER PT J AU LUKEY, BJ CORCORAN, KD SOLANA, RP AF LUKEY, BJ CORCORAN, KD SOLANA, RP TI PHARMACOKINETICS OF DIAZEPAM INTRAMUSCULARLY ADMINISTERED TO RHESUS-MONKEYS SO JOURNAL OF PHARMACEUTICAL SCIENCES LA English DT Article ID CEREBROSPINAL-FLUID; MAJOR METABOLITE; BIOAVAILABILITY AB The purpose of this study was to define the pharmacokinetics of diazepam in monkeys following an im injection of 100-mu-g/kg (the minimum effective dose that prevents nerve agent-induced convulsions in pyridostigmine-pretreated, atropine- and 2-PAM-treated monkeys) in order to predict what im dose in humans is needed to prevent nerve agent-induced convulsions. Six rhesus monkeys were administered diazepam in the hind limb. Blood (3 mL) was collected via an indwelling saphenous catheter immediately prior to and 5, 10, 15, 25, 40, 60, 90, 120, 180, and 240 min after diazepam dosing. A contract laboratory, blind to the labeling code, analyzed diazepam serum concentrations by electron-capture gas chromatography and the percentage of unbound diazepam by equilibrium dialysis. The concentration-time data for total (unbound and bound) diazepam individually determined for each animal was best described by a one-compartment open model with first-order absorption and elimination. The average maximum serum concentration (50 ng/mL) was reached in 29 min. The volume of distribution and systemic clearance, assuming 100% bioavailability, were 1.5 L/kg and 19.4 mL/min/kg, respectively. The percentage of diazepam unbound to serum proteins was 4.6% and, therefore, the maximum concentration of free diazepam was 2.3 ng/mL. These results, when compared with human pharmacokinetic studies, allow a means of extrapolating effective monkey anticonvulsant doses to humans on a pharmacokinetic basis. C1 USA,MED RES INST CHEM DEF,SGRD-UV-PA,ABERDEEN PROVING GROUND,MD 21010. NR 29 TC 5 Z9 5 U1 0 U2 2 PU AMER PHARMACEUTICAL ASSN PI WASHINGTON PA 2215 CONSTITUTION AVE NW, WASHINGTON, DC 20037 SN 0022-3549 J9 J PHARM SCI JI J. Pharm. Sci. PD OCT PY 1991 VL 80 IS 10 BP 918 EP 921 DI 10.1002/jps.2600801003 PG 4 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology & Pharmacy SC Pharmacology & Pharmacy; Chemistry GA GJ248 UT WOS:A1991GJ24800002 PM 1783998 ER PT J AU AKKARA, JA SENECAL, KJ KAPLAN, DL AF AKKARA, JA SENECAL, KJ KAPLAN, DL TI SYNTHESIS AND CHARACTERIZATION OF POLYMERS PRODUCED BY HORSERADISH-PEROXIDASE IN DIOXANE SO JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY LA English DT Article ID ORGANIC-SOLVENTS; ENZYMATIC CATALYSIS; MEDIA; RESOLUTION; WATER; NMR AB Polymers were synthesized from substituted phenolic and aromatic amine compounds with hydrogen peroxide as the source of an oxidizing agent and horseradish peroxidase enzyme as the catalyst. The polymerization reaction was carried out in a monophasic organic solvent with small amounts of water at room temperature. Conditions for the synthesis of polymers with respect to reaction time and yield were studied with a number of monomers at different concentrations and in solvents with different buffers with pH range of 5.0-7.5. Physical and chemical properties of these homo- and copolymers were determined with respect to melting point, solubility, elemental analysis, molecular weight distribution, infrared absorption (including FTIR), solid-state C-13 nuclear magnetic resonance, thermal gravimetric analysis, and differential scanning calorimetry. The enzyme catalyzed reactions produced polymers of molecular weight greater than 400,000 which were further fractionated by differential solubility in solvent mixtures and the molecular weight distribution of the polymer fractions were determined. In general, the polymers synthesized have low solubilities, high melting points, and some degree of branching. RP AKKARA, JA (reprint author), USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760, USA. RI Senecal, Kris/F-3000-2013 NR 22 TC 226 Z9 232 U1 1 U2 25 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0887-624X J9 J POLYM SCI POL CHEM JI J. Polym. Sci. Pol. Chem. PD OCT PY 1991 VL 29 IS 11 BP 1561 EP 1574 DI 10.1002/pola.1991.080291105 PG 14 WC Polymer Science SC Polymer Science GA GF543 UT WOS:A1991GF54300005 ER PT J AU CROSIER, R AF CROSIER, R TI FORTRAN PROGRAMMING TECHNIQUES SO JOURNAL OF QUALITY TECHNOLOGY LA English DT Article DE COMPUTER PROGRAM OPTIMIZATION; STRUCTURED PROGRAMMING AB Suggestions are given for writing clear, correct code and for writing code that minimizes the computer run time of the program. RP CROSIER, R (reprint author), USA,CTR CHEM RES DEV & ENGN,DIV PHYS,ABERDEEN PROVING GROUND,MD 21010, USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC QUALITY CONTROL-ASQC PI MILWAUKEE PA ASQC MEMBERSHIP MANAGER 611 E. WISCONSIN AVENUE, MILWAUKEE, WI 53202 SN 0022-4065 J9 J QUAL TECHNOL JI J. Qual. Technol. PD OCT PY 1991 VL 23 IS 4 BP 348 EP 354 PG 7 WC Engineering, Industrial; Operations Research & Management Science; Statistics & Probability SC Engineering; Operations Research & Management Science; Mathematics GA GG633 UT WOS:A1991GG63300010 ER PT J AU HORWITZ, AR TURNER, CW FABRY, DA AF HORWITZ, AR TURNER, CW FABRY, DA TI EFFECTS OF DIFFERENT FREQUENCY-RESPONSE STRATEGIES UPON RECOGNITION AND PREFERENCE FOR AUDIBLE SPEECH STIMULI SO JOURNAL OF SPEECH AND HEARING RESEARCH LA English DT Article DE HEARING AIDS; AMPLIFICATION; SENSORINEURAL HEARING LOSS; SPEECH RECOGNITION ID HEARING-IMPAIRED SUBJECTS; NOISE; AID; LISTENERS; THRESHOLD; MASKING; FILTER C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP HORWITZ, AR (reprint author), SYRACUSE UNIV,805 S CROUSE AVE,SYRACUSE,NY 13244, USA. FU NIDCD NIH HHS [DC00377] NR 30 TC 16 Z9 16 U1 0 U2 0 PU AMER SPEECH-LANG-HEARING ASSN PI ROCKVILLE PA 10801 ROCKVILLE PIKE RD, ROCKVILLE, MD 20852-3279 SN 0022-4685 J9 J SPEECH HEAR RES JI J. Speech Hear. Res. PD OCT PY 1991 VL 34 IS 5 BP 1185 EP 1196 PG 12 WC Language & Linguistics; Rehabilitation SC Linguistics; Rehabilitation GA GJ652 UT WOS:A1991GJ65200026 PM 1749248 ER PT J AU BARWEY, D GAONKAR, GH ORMISTON, RA AF BARWEY, D GAONKAR, GH ORMISTON, RA TI INVESTIGATION OF DYNAMIC STALL EFFECTS ON ISOLATED ROTOR FLAP-LAG STABILITY WITH EXPERIMENTAL CORRELATION SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB The effects of dynamic stall lift and drag on the flap-lag stability of an isolated hingeless rotor blade are investigated. The emphasis is on the correlation with measured regressing lead-lag mode damping levels of a soft-inplane, three-bladed model rotor, operated untrimmed. The correlation covers a wide range of test conditions for several values of rotor speed, collective pitch angle, shaft tilt angle, and advance ratio. It includes cases that vary from near zero thrust condition in hover to highly stalled forward-flight conditions with advance ratios as high as 0.55 and shaft tilt angles as high as 20-degrees. Both the experimental and analytical blade models represent a simple model of a hingeless rotor with rigid blades and spring restrained flap-lag hinges. The aerodynamic representation is based on the ONERA dynamic stall models comprising virtually independent unified lift and drag models. The nonlinear equations of blade motion and stall dynamics are perturbed about a periodic forced response, and the damping is evaluated by the Floquet eigenanalysis. In comparison to the linear and quasisteady stall aerodynamic theories, the theory with dynamic stall lift and quasisteady stall drag qualitatively improves the correlation, and adding dynamic stall drag provides further quantitative improvement. C1 USA,AVIAT RES & TECHNOL ACT,AVIAT SYST COMMAND,AEROFLIGHTDYNAM DIRECTORATE,MOFFETT FIELD,CA. RP BARWEY, D (reprint author), FLORIDA ATLANTIC UNIV,DEPT MECH ENGN,BOCA RATON,FL 33431, USA. NR 13 TC 7 Z9 8 U1 0 U2 0 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD OCT PY 1991 VL 36 IS 4 BP 12 EP 24 PG 13 WC Engineering, Aerospace SC Engineering GA GR647 UT WOS:A1991GR64700002 ER PT J AU KALETKA, J TISCHLER, MB VONGRUNHAGEN, W FLETCHER, JW AF KALETKA, J TISCHLER, MB VONGRUNHAGEN, W FLETCHER, JW TI TIME AND FREQUENCY-DOMAIN IDENTIFICATION AND VERIFICATION OF BO-105 DYNAMIC-MODELS SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB Mathematical models for the dynamics of the DLR BO 105 helicopter are extracted from flight test data using two different approaches: frequency-domain and time-domain identification. Both approaches are reviewed. Results from an extensive data consistency analysis are given. Identifications for 6-degrees-of-freedom (DOF) rigid-body models are presented and compared in detail. The extracted models compare favorably and their prediction capability is demonstrated. Approaches to extend the 6-DOF models are addressed and first results are presented. C1 USA,AVIAT RES & TECHNOL ACT,AMES RES CTR,AEROFLIGHTDYNAM DIRECTORATE,MOFFETT FIELD,CA. RP KALETKA, J (reprint author), DFVLR,INST FLUGMECH,BRAUNSCHWEIG,GERMANY. NR 14 TC 2 Z9 2 U1 0 U2 4 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD OCT PY 1991 VL 36 IS 4 BP 25 EP 38 PG 14 WC Engineering, Aerospace SC Engineering GA GR647 UT WOS:A1991GR64700003 ER PT J AU CONDONRALL, ME AF CONDONRALL, ME TI ALLIED COOPERATION IN MALARIA PREVENTION AND CONTROL - THE WORLD-WAR-II SOUTHWEST PACIFIC EXPERIENCE SO JOURNAL OF THE HISTORY OF MEDICINE AND ALLIED SCIENCES LA English DT Article C1 USA,CTR MIL HIST,WASHINGTON,DC 20310. NR 15 TC 9 Z9 9 U1 0 U2 1 PU J HIST MED ALLIED SCI INC PI CANTON PA PO BOX 487, CANTON, MA 02021 SN 0022-5045 J9 J HIST MED ALL SCI JI J. Hist. Med. Allied Sci. PD OCT PY 1991 VL 46 IS 4 BP 493 EP 513 DI 10.1093/jhmas/46.4.493 PG 21 WC Health Care Sciences & Services; History & Philosophy Of Science SC Health Care Sciences & Services; History & Philosophy of Science GA GM547 UT WOS:A1991GM54700005 PM 1744433 ER PT J AU JOHNSON, DE GAMBLE, WB AF JOHNSON, DE GAMBLE, WB TI TRAUMA IN THE ARCTIC - AN INCIDENT REPORT SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article ID ACCIDENTAL HYPOTHERMIA; COLD; RESUSCITATION; MANAGEMENT; CRASHES; INJURY AB On January 29, 1989, a military aircraft crashed on approach to an airfield in Alaska. The subsequent extraction, evacuation, and casualty resuscitation occurred at temperatures lower than -50-degrees-F. Both the medical and military literature are replete with instructions and advice regarding the handling of trauma victims in the field in the Arctic environment; however, case reviews of such incidents are rare. In this case, the circumstances of the incident, and the organizations on which it fell, argued for almost ideal handling of the care of the victims. Problems that have an impact on the availability of casualty management, generally, in the Arctic such as a widely scattered population and sparse medical facilities, poorly defined evacuation routes, and marginal communication patterns, were not encountered in this review because of the unusual circumstances of this incident. The difficulties of field care in this environment, even under "ideal" conditions, however, are real and evident in this case history. Transportation assets are critical. Rehearsal, critique, refinement, and re-rehearsal of a mass casualty plan can significantly increase victim survival. Proper protocols and confidence in them take on an importance far beyond their benefit in a more temperate environment. Procedures must be worked out in advance, known by all concerned, and practiced, because the "rescuer" is at the same risk of hypothermia as the "victim" and, in addition, is responsible for thinking for the incapacitated patient. Rote-learned drills will be acknowledged far longer in the cold than unspecific guidelines. Survival for trauma victims may depend on those rote actions. C1 WALTER REED ARMY MED CTR,INTRAMURAL RES SERV,WASHINGTON,DC 20307. RP JOHNSON, DE (reprint author), USA,MED DEPT ACTIV ALASKA,OFF COMMANDER,FT WAINWRIGHT,AK 99703, USA. NR 36 TC 1 Z9 1 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD OCT PY 1991 VL 31 IS 10 BP 1340 EP 1346 DI 10.1097/00005373-199110000-00003 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA GM785 UT WOS:A1991GM78500003 PM 1942139 ER PT J AU SIMPSON, MB GREENFIELD, GQ AF SIMPSON, MB GREENFIELD, GQ TI IRREDUCIBLE DORSAL DISLOCATION OF THE SMALL FINGER DISTAL INTERPHALANGEAL JOINT - THE IMPORTANCE OF ROENTGENOGRAMS - CASE-REPORT SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article AB Irreducible dorsal dislocations of the distal interphalangeal joints of the fingers are uncommon injuries. They are almost always the result of an athletic injury. Although usually open, these can be subtle, closed injuries. Proper diagnosis requires clinical awareness and mandatory roentgenograms of all interphalangeal joint injuries. RP SIMPSON, MB (reprint author), BROOKE ARMY MED CTR,ORTHOPAED SURG SERV,FT SAM HOUSTON,TX 78234, USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD OCT PY 1991 VL 31 IS 10 BP 1450 EP 1454 PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA GM785 UT WOS:A1991GM78500029 PM 1942165 ER PT J AU MOUL, JW FOLEY, JP WIND, GG RUBIN, S COFFEY, JA MCLEOD, DG AF MOUL, JW FOLEY, JP WIND, GG RUBIN, S COFFEY, JA MCLEOD, DG TI CELIAC AXIS AND SUPERIOR MESENTERIC-ARTERY INJURY ASSOCIATED WITH LEFT RADICAL NEPHRECTOMY FOR LOCALLY ADVANCED RENAL-CELL CARCINOMA SO JOURNAL OF UROLOGY LA English DT Article DE CARCINOMA; RENAL CELL; KIDNEY NEOPLASMS; WOUNDS AND INJURIES; SUPERIOR MESENTERIC ARTERY SYNDROME; DUODENAL OBSTRUCTION ID COMPLICATION AB The superior mesenteric artery and celiac axis were inadvertently ligated during left radical nephrectomy for a large upper pole renal carcinoma with massive perihilar and periaortic adenopathy. Computer-generated 3-dimensional illustrations created from the computerized tomography scan demonstrated the close proximity between these visceral branches and the adenopathy-mass complex, and showed how this bulky disease may interfere with surgical anatomy. When left radical nephrectomy is performed for locally advanced and/or bulky node-positive renal neoplasms, surgeons must be cognizant of the location of the major visceral arterial branches and possible anatomical distortions. C1 WALTER REED ARMY MED CTR,DEPT SURG,ANESTHESIA SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT SURG,VASC SERV,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. RP MOUL, JW (reprint author), WALTER REED ARMY MED CTR,DEPT SURG,UROL SERV,WASHINGTON,DC 20307, USA. NR 21 TC 9 Z9 10 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD OCT PY 1991 VL 146 IS 4 BP 1104 EP 1108 PG 5 WC Urology & Nephrology SC Urology & Nephrology GA GJ155 UT WOS:A1991GJ15500040 PM 1895432 ER PT J AU BUEHLER, DA FRASER, JD SEEGAR, JKD THERRES, GD BYRD, MA AF BUEHLER, DA FRASER, JD SEEGAR, JKD THERRES, GD BYRD, MA TI SURVIVAL RATES AND POPULATION-DYNAMICS OF BALD EAGLES ON CHESAPEAKE BAY SO JOURNAL OF WILDLIFE MANAGEMENT LA English DT Article AB Survival of 39 radio-tagged bald eagles (Haliaeetus leucocephalus) in the Chesapeake Bay region was 100% in the first year of life. Mean minimum survival per year of all eagles was 91% (95% CI = 86-96%); mean maximum survival was 98% (95% CI = 96-100%). A deterministic life-table model predicted a finite growth rate of 5.8% per year, whereas the growth rate based on the maximum survival estimates was 16.6% per year. The breeding population actually increased 12.6% per year from 1986 to 1990. We estimated the intrinsic growth rate at 6.9% based on natality and minimum survival data and 19.2% based on maximum survival data. Because eagle habitat is being converted to human developments at a rapid rate on the Chesapeake, models incorporating these habitat losses are needed to accurately predict future population trends. C1 USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. MARYLAND FOREST PK & WILDLIFE SERV,WYE MILLS,MD 21679. COLL WILLIAM & MARY,DEPT BIOL,WILLIAMSBURG,VA 23186. RP BUEHLER, DA (reprint author), VIRGINIA POLYTECH INST & STATE UNIV,DEPT FISHERIES & WILDLIFE SCI,BLACKSBURG,VA 24061, USA. NR 17 TC 36 Z9 36 U1 1 U2 6 PU WILDLIFE SOC PI BETHESDA PA 5410 GROSVENOR LANE, BETHESDA, MD 20814-2197 SN 0022-541X J9 J WILDLIFE MANAGE JI J. Wildl. Manage. PD OCT PY 1991 VL 55 IS 4 BP 608 EP 613 DI 10.2307/3809506 PG 6 WC Ecology; Zoology SC Environmental Sciences & Ecology; Zoology GA GW663 UT WOS:A1991GW66300010 ER PT J AU BULUSU, S AXENROD, T LIANG, B HE, Y YUAN, L AF BULUSU, S AXENROD, T LIANG, B HE, Y YUAN, L TI ASSIGNMENT OF THE H-1, C-13 AND N-15 RESONANCES IN CYCLODEXTRIN NITRATES BY 2D NMR AND THE DETERMINATION OF THE REGIOSELECTIVITY OF THE HYDROXYLAMINE-INDUCED DENITRATION REACTIONS SO MAGNETIC RESONANCE IN CHEMISTRY LA English DT Article DE ALPHA-CYCLODEXTRIN NITRATE; BETA-CYCLODEXTRIN NITRATE; HYDROXYLAMINE DENITRATION; N-15-O-C-H1 SHIFT CORRELATIONS ID SPECTROSCOPY; SPECTRA AB Hexakis(2,3,6-tri-O-nitro)-alpha-cyclodextrin and heptakis(2,3,6-tri-O-nitro)-beta-cyclodextrin were prepared and the complete assignment of the H-1, C-13 and N-15 resonance signals in each case was achieved using homonuclear shift correlation experiments, one-bond C-13-H-1 and three-bond N-15-O-C-H-1 heteronuclear shift correlation measurements. The denitration of these cyclodextrin nitrates by hydroxylamine in pyridine was investigated to study its selectivity in preparing partially nitrated derivatives of these cyclodextrins. The sites of denitration were determined in each case using C-13 and N-15 NMR and the products were completely characterized. The results indicate that denitration of these cyclodextrin nitrates is a highly regiospecific reaction occurring at the 2-position only and giving rise to hexakis(3,6-di-O-nitro)-alpha-cyclodextrin and heptakis(3,6-di-O-nitro)-beta-cyclodextrin, respectively. C1 CUNY CITY COLL, DEPT CHEM, NEW YORK, NY 10031 USA. USA, ARMAMENTS RES, CTR DEV & ENGN, PICATINNY ARSENAL, NJ 07806 USA. NR 21 TC 7 Z9 7 U1 1 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0749-1581 EI 1097-458X J9 MAGN RESON CHEM JI Magn. Reson. Chem. PD OCT PY 1991 VL 29 IS 10 BP 1018 EP 1023 DI 10.1002/mrc.1260291008 PG 6 WC Chemistry, Multidisciplinary; Chemistry, Physical; Spectroscopy SC Chemistry; Spectroscopy GA GK543 UT WOS:A1991GK54300007 ER PT J AU JEFFER, EK AF JEFFER, EK TI TOTAL QUALITY MANAGEMENT AND THE ARMY HEALTH-CARE SYSTEM SO MILITARY MEDICINE LA English DT Article AB Total quality management (TQM) is the newest in a long line of magic formulas which have been touted as saviors for American industry and medicine. The author discusses the basic concepts of TQM and notes that much of it resembles philosophical beliefs long held by the medical community. TQM does offer many opportunities to refine old concepts and further those goals of quality care to which health care providers have always aspired. If, however, it becomes simply another codified bureaucracy, then a great deal of time and money will be invested for very little gain. RP JEFFER, EK (reprint author), USA,DIV QUAL ASSURANCE,OFF SURGEON GEN,FALLS CHURCH,VA 22041, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 1991 VL 156 IS 10 BP 546 EP 550 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA GK669 UT WOS:A1991GK66900019 PM 1749501 ER PT J AU LUCEY, DR AF LUCEY, DR TI THE 1ST DECADE OF HUMAN RETROVIRUSES - A NOMENCLATURE FOR THE CLINICIAN SO MILITARY MEDICINE LA English DT Article AB The decade of the 1980s has provided at least 10 terms for human retroviruses, of which five are currently recognized as defining distinct human infectious disease agents. Of these five, three are human T-cell lymphotropic viruses (HTLV-I, HTLV-II, HTLV-V) and two are human immunodeficiency viruses (HIV-1, HIV-2). HIV-1 and HIV-2 can cause the acquired immunodeficiency syndrome (AIDS), whereas HTLV-I, HTLV-II, and HTLV-V do not. HTLV-I can cause a T-cell leukemia/lymphoma as well as a progressive myelopathy. Disease(s) caused by HTLV-II and HTLV-V have yet to be conclusively established. Screening of the blood supply in the United States is currently designed to detect two of these retroviruses (HIV-1, HTLV-I). This review seeks to clarify the nomenclature of human retroviruses as we begin the second decade of their recognition. RP LUCEY, DR (reprint author), WALTER REED ARMY MED CTR,DEPT RETROVIRAL RES,ROCKVILLE,MD 20850, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 1991 VL 156 IS 10 BP 555 EP 557 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA GK669 UT WOS:A1991GK66900021 PM 1660967 ER PT J AU BURCH, GR AF BURCH, GR TI PHYSICAL-TRAINING SO MILITARY MEDICINE LA English DT Letter RP BURCH, GR (reprint author), USA,OTOLARYNGOL SERV,FT GORDON,GA 30905, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 1991 VL 156 IS 10 BP A14 EP A14 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA GK669 UT WOS:A1991GK66900007 PM 1749492 ER PT J AU VENKATESAN, MM BUYSSE, JM HARTMAN, AB AF VENKATESAN, MM BUYSSE, JM HARTMAN, AB TI SEQUENCE VARIATION IN 2 IPAH GENES OF SHIGELLA-FLEXNERI 5 AND HOMOLOGY TO THE LRG-LIKE FAMILY OF PROTEINS SO MOLECULAR MICROBIOLOGY LA English DT Article ID AMINO-ACID SEQUENCE; LEUCINE-RICH ALPHA-2-GLYCOPROTEIN; ENTEROINVASIVE ESCHERICHIA-COLI; PLATELET GLYCOPROTEIN-IB; PLASMID ANTIGEN GENE; MOLECULAR CHARACTERIZATION; RIBONUCLEASE INHIBITOR; TRANSMEMBRANE PROTEIN; INSERTION SEQUENCES; YERSINIA-PESTIS AB Oligonucleotide primers derived from the ipaH7.8 sequence have been used to determine the boundaries of DNA sequence homology among five ipaH genes on the invasion plasmid (pWR100) of Shigella flexneri 5, strain M9OT-W. The primary structure of IpaH4.s has been established from DNA sequence analysis. The first 197 amino acids in IpaH7.8 were replaced in IpaH4.5 by a unique set of 251 amino acids, generating two related proteins with variable and conserved sequences. The amino-terminal region of IpaH4.5 displayed an internal repeat structure, also seen in IpaH7.8, characteristic of members of the leucine-rich glycoprotein (LRG) family. The DNA sequences of ipaH2.5 and ipaH1.4 indicate that these genes are truncated versions of iPaH7.8. Western blot analysis of a lambda-gt11 ipaH recombinant (W7) subclone demonstrated that the antigenicity of IpaH7.8 resides outside the leucine-rich repetitive region. C1 WALTER REED ARMY MED CTR,DEPT BIOL RES,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. RP VENKATESAN, MM (reprint author), WALTER REED ARMY MED CTR,DEPT BACTERIAL IMMUNOL,WASHINGTON,DC 20307, USA. NR 39 TC 45 Z9 46 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0950-382X J9 MOL MICROBIOL JI Mol. Microbiol. PD OCT PY 1991 VL 5 IS 10 BP 2435 EP 2445 DI 10.1111/j.1365-2958.1991.tb02089.x PG 11 WC Biochemistry & Molecular Biology; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA GL954 UT WOS:A1991GL95400016 PM 1791758 ER PT J AU RAY, P MONROE, FL BERMAN, JD FIEDLER, J AF RAY, P MONROE, FL BERMAN, JD FIEDLER, J TI CYANIDE SENSITIVE AND INSENSITIVE BIOENERGETICS IN A CLONAL NEUROBLASTOMA X GLIOMA HYBRID CELL-LINE SO NEUROCHEMICAL RESEARCH LA English DT Article DE NG108-15 CELLS; CYANIDE; 2-DEOXY GLUCOSE; ATP DEPLETION; METABOLIC INHIBITION; CYANIDE ANTIDOTE ID INTOXICATION; CULTURE; ANTAGONISM; MECHANISMS AB The primary mechanism of cyanide (CN) intoxication is the inhibition of metabolism in the central nervous system. We determined the effects of CN on several biochemical processes in neuroblastoma x glioma hybrid NG108-15 cells, which posses numerous neuronal properties. These cells were not sensitive to a high concentration (1 mM) of NaCN, but became sensitive in the presence of the anaerobic glycolysis inhibitors sodium iodoacetate (IA) and 2-deoxyglucose (2-DG): cellular metabolic processes (e.g., DNA, RNA and protein synthesis) decreased to about 40% of control due to treatment with 0.5 mM NaCN + 0.05 mM IA and 0.1 mM NaCN + 20 mM 2-DG. ATP in cells exposed to 0.01 or 0.1 mM NaCN + 20 mM 2-DG was reduced 75% and 100% respectively within one min. Pretreatment of cells with the CN antidote cobalt (II) chloride (CoCl2) (0.06 - 0.18 mM) for 5 min prevented the depression of both [H-3]leucine incorporation and ATP synthesis due to 1 mM NaCN + 20 mM 2-DG in a concentration-dependent manner. A proposed CN antidote alpha-ketoglutaric acid (disodium salt) also prevented the depression of cellular metabolism due to NaCN plus 2-DG. These results indicate that blocking anaerobic glycolysis makes NG108-15 cells sensitive to a low concentration of CN. Thus NG108-15 cells should be useful to study the mechanisms of neurotoxicity of CN and to test antidotes. C1 NIDDK,CELL BIOL & GENET LAB,BETHESDA,MD 20892. RP RAY, P (reprint author), WALTER REED ARMY MED CTR,DEPT BIOL,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. RI Fiedler, Jenny/I-5617-2016 NR 21 TC 6 Z9 6 U1 0 U2 0 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0364-3190 J9 NEUROCHEM RES JI Neurochem. Res. PD OCT PY 1991 VL 16 IS 10 BP 1121 EP 1124 DI 10.1007/BF00966589 PG 4 WC Biochemistry & Molecular Biology; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA GK148 UT WOS:A1991GK14800003 PM 1795758 ER PT J AU BERLIN, RH AF BERLIN, RH TI BETRAYALS - FORT-WILLIAM-HENRY AND THE MASSACRE - STEELE,IK SO NEW YORK HISTORY LA English DT Book Review RP BERLIN, RH (reprint author), US ARMY COMMAND GENERAL STAFF COLL,FT LEAVENWORTH,KS 66027, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU NEW YORK STATE HIST ASSN PI COOPERSTOWN PA PO BOX 800, COOPERSTOWN, NY 13326-0800 SN 0146-437X J9 NEW YORK HIST JI N. Y. Hist. PD OCT PY 1991 VL 72 IS 4 BP 441 EP 443 PG 3 WC History SC History GA GY308 UT WOS:A1991GY30800006 ER PT J AU WATKINS, WR CROW, SB KANTROWITZ, FT AF WATKINS, WR CROW, SB KANTROWITZ, FT TI CHARACTERIZING ATMOSPHERIC EFFECTS ON TARGET CONTRAST SO OPTICAL ENGINEERING LA English DT Article DE TARGET CONTRAST; ATMOSPHERIC PROPAGATION; THERMAL IMAGING; CONTRAST TRANSMISSION; MODULATION TRANSFER FUNCTION; SPECTRAL RESPONSE ID WEATHER AB A methodology is presented for the characterization of atmospheric effects on the propagation of target contrast. The basic concept is to compare matched images simultaneously along a common line of sight from two imagers-one close up or in the near field and the other at engagement range or in the far field. One-to-one pixel comparison of these target scenes allows degradation of target contrast caused by propagation effects between the near-field and far-field positions to be quantified. Temporal changes of inherent signature can be quantified by monitoring the changes in the near-field imagery. The real-time image processing techniques, proof of principle guidelines, and several applications of the methodology are detailed. RP WATKINS, WR (reprint author), USA,ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002, USA. NR 8 TC 6 Z9 6 U1 0 U2 0 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD OCT PY 1991 VL 30 IS 10 BP 1563 EP 1575 DI 10.1117/12.55977 PG 13 WC Optics SC Optics GA GK745 UT WOS:A1991GK74500017 ER PT J AU HUDSON, TD GREGORY, DA AF HUDSON, TD GREGORY, DA TI OPTICALLY-ADDRESSED SPATIAL LIGHT MODULATORS SO OPTICS AND LASER TECHNOLOGY LA English DT Article DE SPATIAL LIGHT MODULATORS; OPTICAL PROCESSING; RESOLUTION; PERFORMANCE CHARACTERISTICS ID LIQUID-CRYSTAL AB The performance characteristics of three unique optically-addressed spatial light modulators (SLMs) have been experimentally investigated. The measured parameters include resolution, visibility, imaging response time, and write light sensitivity. The modulators investigated include two relatively new technologies, the ferroelectric liquid crystal (FLC) SLM from the University of Colorado-Boulder and the amorphous silicon photoconductive twisted nematic liquid crystal SLM from GEC-Marconi Research, and a well-established industry benchmark, the Hughes Liquid Crystal Light Valve (LCLV). RP HUDSON, TD (reprint author), USA,MISSILE COMMAND,AMSMI,RDWSPO,REDSTONE ARSENAL,AL 35898, USA. NR 7 TC 5 Z9 5 U1 0 U2 3 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0030-3992 J9 OPT LASER TECHNOL JI Opt. Laser Technol. PD OCT PY 1991 VL 23 IS 5 BP 297 EP 302 DI 10.1016/0030-3992(91)90008-C PG 6 WC Optics; Physics, Applied SC Optics; Physics GA HA177 UT WOS:A1991HA17700004 ER PT J AU ZIESKE, LA KOPKE, RD HAMILL, R AF ZIESKE, LA KOPKE, RD HAMILL, R TI DEMATIACEOUS FUNGAL SINUSITIS SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article ID ALLERGIC ASPERGILLUS SINUSITIS; CURVULARIA-LUNATA; ALTERNARIA OSTEOMYELITIS; DRECHSLERA-SPICIFERA; PHAEOHYPHOMYCOSIS; BIPOLARIS; EXSEROHILUM; INVOLVEMENT; INFECTIONS; DIAGNOSIS AB Six cases of dematiaceous fungal sinusitis are reported, together with a review of 33 other cases collated from a review of the English literature. The sinusitis was more often unilateral vs. bilateral. A characteristic serpiginous hyperdense intrasinus opacification, as well as sinus expansion with bone erosion, was often seen on CT scan. MRI scan showed lucent sinus cavities on T1 and T2 weighting. A comparison of surgical treatment vs. surgery with systemic antifungal therapy revealed decreased recurrence and complication statistics in the combined therapy group. There was a trend toward increased recurrence/persistence and complications associated with invasive histologic findings and only surgical treatment, but not statistically significant. At the present time, we recommend comprehensive surgical treatment followed by systemic antifungal therapy, though clinical judgment and individualization should occur. Future studies are planned to further define the disease entity and its therapy. C1 TRIPLER ARMY MED CTR,DEPT PATHOL,HONOLULU,HI 96859. RP ZIESKE, LA (reprint author), TRIPLER ARMY MED CTR,DEPT SURG,OTOLARYNGOL SERV,HONOLULU,HI 96859, USA. NR 32 TC 51 Z9 52 U1 1 U2 2 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD OCT PY 1991 VL 105 IS 4 BP 567 EP 577 PG 11 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA GL065 UT WOS:A1991GL06500008 PM 1762793 ER PT J AU BASS, JW AF BASS, JW TI ANTIBIOTIC MANAGEMENT OF GROUP-A STREPTOCOCCAL PHARYNGOTONSILLITIS SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE PHARYNGOTONSILLITIS; GROUP-A BETA-HEMOLYTIC STREPTOCOCCUS; PENICILLIN-V; RHEUMATIC FEVER ID BETA-HEMOLYTIC STREPTOCOCCI; PENICILLIN-G BENZATHINE; UPPER RESPIRATORY-TRACT; ERYTHROMYCIN THERAPY; V THERAPY; PHARYNGITIS; TOLERANCE; CHILDREN; FAILURE; FORMULATIONS RP BASS, JW (reprint author), TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859, USA. NR 69 TC 28 Z9 28 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD OCT PY 1991 VL 10 IS 10 SU S BP S43 EP S49 DI 10.1097/00006454-199110001-00010 PG 7 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA GK195 UT WOS:A1991GK19500010 PM 1945596 ER PT J AU KLEIN, JO QUIE, PG AYOUB, EM SHULMAN, ST GERBER, MA HOLM, SE FERRIERI, P BASS, JW PICHICHERO, ME ROGAN, M EICKHOFF, TC DAJANI, AS RODRIQUEZ, RS AF KLEIN, JO QUIE, PG AYOUB, EM SHULMAN, ST GERBER, MA HOLM, SE FERRIERI, P BASS, JW PICHICHERO, ME ROGAN, M EICKHOFF, TC DAJANI, AS RODRIQUEZ, RS TI PROCEEDINGS OF A SYMPOSIUM - GROUP-A STREPTOCOCCAL INFECTIONS - AN ERA OF GROWING CONCERN - DISCUSSION SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Discussion C1 UNIV FLORIDA,SCH MED,DEPT PEDIAT,GAINESVILLE,FL 32611. TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859. WAYNE STATE UNIV,CHILDRENS HOSP MICHIGAN,DIV INFECT DIS,DETROIT,MI 48202. PRESBYTERIAN ST LUKES MED CTR,DEPT INTERNAL MED,DENVER,CO. UNIV MINNESOTA,SCH MED,DEPT LAB MED & PATHOL,DIV INFECT DIS,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,SCH MED,DEPT PEDIAT,DIV INFECT DIS,MINNEAPOLIS,MN 55455. UNIV CONNECTICUT,CTR HLTH,DEPT PEDIAT,FARMINGTON,CT 06032. UMEA UNIV,DEPT CLIN BACTERIOL,S-90187 UMEA,SWEDEN. UNIV ROCHESTER,ELMWOOD MED GRP,DEPT PEDIAT,ROCHESTER,NY 14627. UNIV MINNESOTA,SCH MED,DEPT PEDIAT,MINNEAPOLIS,MN 55455. HOSP INFANTIL MEXICO DR FEDERICO GOMEZ,MEXICO CITY,DF,MEXICO. BRISTON MYERS SQUIBB,US PHARMACEUT DIV,ANTI INFECT GRP,PRINCETON,NJ. NORTHWESTERN UNIV,CHILDRENS MEM HOSP,DEPT PEDIAT,DIV INFECT DIS,CHICAGO,IL 60614. RP KLEIN, JO (reprint author), BOSTON UNIV,BOSTON CITY HOSP,SCH MED,DEPT PEDIAT,DEPT PEDIAT INFECT DIS,BOSTON,MA 02118, USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD OCT PY 1991 VL 10 IS 10 SU S BP S32 EP S38 PG 7 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA GK195 UT WOS:A1991GK19500008 ER PT J AU PICHICHERO, ME GERBER, MA HOLM, SE ROGAN, M KLEIN, JO AYOUB, EM BASS, JW SAULMAN, ST FERRIERI, P QUIE, PG VANCAUWENBERGE, PB DAJANI, AS MILATOVIC, D VANDEPITTE, J RODRIQUEZ, RS NOLEN, TM AF PICHICHERO, ME GERBER, MA HOLM, SE ROGAN, M KLEIN, JO AYOUB, EM BASS, JW SAULMAN, ST FERRIERI, P QUIE, PG VANCAUWENBERGE, PB DAJANI, AS MILATOVIC, D VANDEPITTE, J RODRIQUEZ, RS NOLEN, TM TI PROCEEDINGS OF A SYMPOSIUM - GROUP-A STREPTOCOCCAL INFECTIONS - AN ERA OF GROWING CONCERN - DISCUSSION SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Discussion C1 HOSP INFANTIL MEXICO DR FEDERICO GOMEZ,MEXICO CITY,DF,MEXICO. UNIV ALABAMA,COLL COMMUNITY HLTH SCI,TUSCALOOSA,AL 35401. UNIV MINNESOTA,SCH MED,DEPT LAB MED & PATHOL,DIV INFECT DIS,MINNEAPOLIS,MN 55455. STATE UNIV HOSP GHENT,DEPT OTORHINOLARYNGOLOGY,GHENT,BELGIUM. WAYNE STATE UNIV,CHILDRENS HOSP MICHIGAN,DIV INFECT DIS,DETROIT,MI 48202. TECH UNIV MUNICH,INST MICROBIOL,W-8000 MUNICH 2,GERMANY. CATHOLIC UNIV LEUVEN,ST RAPHAEL HOSP,DEPT CLIN MICROBIOL,B-3000 LOUVAIN,BELGIUM. UNIV CONNECTICUT,CTR HLTH,DEPT PEDIAT,FARMINGTON,CT 06032. UMEA UNIV,DEPT CLIN BACTERIOL,S-90187 UMEA,SWEDEN. BRISTON MYERS SQUIBB,US PHARMACEUT DIV,ANTI INFECT GRP,PRINCETON,NJ. BOSTON UNIV,BOSTON CITY HOSP,SCH MED,DEPT PEDIAT,DIV PEDIAT INFECT DIS,BOSTON,MA 02118. UNIV FLORIDA,SCH MED,DEPT PEDIAT,GAINESVILLE,FL 32611. TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859. NORTHWESTERN UNIV,CHILDRENS MEM HOSP,DEPT PEDIAT,DIV INFECT DIS,CHICAGO,IL 60614. UNIV MINNESOTA,SCH MED,DEPT PEDIAT,DIV INFECT DIS,MINNEAPOLIS,MN 55455. RP PICHICHERO, ME (reprint author), UNIV ROCHESTER,ELMWOOD MED GRP,DEPT PEDIAT,ROCHESTER,NY 14627, USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD OCT PY 1991 VL 10 IS 10 SU S BP S72 EP S78 PG 7 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA GK195 UT WOS:A1991GK19500016 ER PT J AU BOND, VP BENARY, V SONDHAUS, CA AF BOND, VP BENARY, V SONDHAUS, CA TI A DIFFERENT PERCEPTION OF THE LINEAR, NONTHRESHOLD HYPOTHESIS FOR LOW-DOSE IRRADIATION SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE RADIATION PROTECTION; LOW-LEVEL RADIATION; RADIOEPIDEMIOLOGY; THRESHOLDS ID QUALITY AB Two equally useful dosimetric quantities, both of which are called dose, are used in toxicology. With radiation measurement, only one-the energy per unit mass D-is called dose. The other-the total energy in the irradiated system-is here distinguished from D by assigning it the name collective energy, epsilon. The collective energy is a more complete statement of dose because it is the product of the energy concentration D and the mass irradiated m. Especially in radioepidemiology, in which epsilon is the total energy imparted to all persons irradiated, the quantity m must be specified because it is situation specific and thus highly variable. At present, radioepidemiological dose-response curves are given only in terms of the toxicological model-i.e., the fraction (probability) of radiation-attributable cancers occurring as a function of D. Because this relation does not involve the number of persons at each value of D, it fosters the illusion that any dose, no matter how small, can result in cancer. However, we show that if the dose-response relationship is expressed in terms of the absolute number of attributable cancers as a function of epsilon, cancer occurs, on average, only if the collective energy exceeds a relatively large minimum value, the magnitude of which will be estimated. Therefore, we conclude that the nonthreshold aspect of the linear hypothesis is misleading and quite probably invalid. For example, in or around a facility in which exposure of humans to relatively low values of D occurs, attributable cancers are most unlikely to appear unless the epsilon to the irradiated population exceeds this minimum value. C1 TEL AVIV UNIV,SCH PHYS,IL-69456 TEL AVIV,ISRAEL. USA,SCH CHEM,BRADLEY RADIOL LAB,FT MCCLELLAN,AL 36205. RP BOND, VP (reprint author), BROOKHAVEN NATL LAB,DEPT MED,UPTON,NY 11973, USA. NR 9 TC 14 Z9 15 U1 0 U2 1 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD OCT PY 1991 VL 88 IS 19 BP 8666 EP 8670 DI 10.1073/pnas.88.19.8666 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA GH805 UT WOS:A1991GH80500079 PM 1924328 ER PT J AU RICHARDS, P AF RICHARDS, P TI RIGHT-SIDE-UP ORGANIZATION SO QUALITY PROGRESS LA English DT Article RP RICHARDS, P (reprint author), USA,GEN MAT & PETR ACTIV,NEW CUMBERLAND,PA, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC QUALITY CONTROL-ASQC PI MILWAUKEE PA ASQC MEMBERSHIP MANAGER 611 E. WISCONSIN AVENUE, MILWAUKEE, WI 53202 SN 0033-524X J9 QUAL PROG JI Qual. Prog. PD OCT PY 1991 VL 24 IS 10 BP 95 EP 96 PG 2 WC Engineering, Multidisciplinary; Engineering, Industrial; Management; Operations Research & Management Science SC Engineering; Business & Economics; Operations Research & Management Science GA GH666 UT WOS:A1991GH66600019 ER PT J AU LEDNEY, GD MADONNA, GS ELLIOTT, TB MOORE, MM JACKSON, WE AF LEDNEY, GD MADONNA, GS ELLIOTT, TB MOORE, MM JACKSON, WE TI THERAPY OF INFECTIONS IN MICE IRRADIATED IN MIXED NEUTRON PHOTON FIELDS AND INFLICTED WITH WOUND TRAUMA - A REVIEW OF CURRENT WORK SO RADIATION RESEARCH LA English DT Review ID BONE-MARROW TRANSPLANTATION; CHERNOBYL; OFLOXACIN; SEPSIS RP LEDNEY, GD (reprint author), USA,RADIOBIOL RES INST,DEPT EXPTL HEMATOL,WOUND & INFECT MANAGEMENT,BETHESDA,MD 20889, USA. NR 32 TC 13 Z9 13 U1 0 U2 0 PU RADIATION RESEARCH SOC PI OAK BROOK PA 2021 SPRING RD, STE 600, OAK BROOK, IL 60521 SN 0033-7587 J9 RADIAT RES JI Radiat. Res. PD OCT PY 1991 VL 128 IS 1 SU S BP S18 EP S28 DI 10.2307/3577997 PG 11 WC Biology; Biophysics; Radiology, Nuclear Medicine & Medical Imaging SC Life Sciences & Biomedicine - Other Topics; Biophysics; Radiology, Nuclear Medicine & Medical Imaging GA GK944 UT WOS:A1991GK94400005 PM 1924743 ER PT J AU MACVITTIE, TJ MONROY, R VIGNEULLE, RM ZEMAN, GH JACKSON, WE AF MACVITTIE, TJ MONROY, R VIGNEULLE, RM ZEMAN, GH JACKSON, WE TI THE RELATIVE BIOLOGICAL EFFECTIVENESS OF MIXED FISSION-NEUTRON-GAMMA RADIATION ON THE HEMATOPOIETIC SYNDROME IN THE CANINE - EFFECT OF THERAPY ON SURVIVAL SO RADIATION RESEARCH LA English DT Article ID DIFFERENT-ENERGY NEUTRONS; RBE RP MACVITTIE, TJ (reprint author), USA,RADIOBIOL RES INST,BETHESDA,MD 20889, USA. NR 45 TC 17 Z9 18 U1 0 U2 0 PU RADIATION RESEARCH SOC PI OAK BROOK PA 2021 SPRING RD, STE 600, OAK BROOK, IL 60521 SN 0033-7587 J9 RADIAT RES JI Radiat. Res. PD OCT PY 1991 VL 128 IS 1 SU S BP S29 EP S36 DI 10.2307/3577998 PG 8 WC Biology; Biophysics; Radiology, Nuclear Medicine & Medical Imaging SC Life Sciences & Biomedicine - Other Topics; Biophysics; Radiology, Nuclear Medicine & Medical Imaging GA GK944 UT WOS:A1991GK94400006 PM 1924744 ER PT J AU REDPATH, JL SUN, C BLAKELY, WF AF REDPATH, JL SUN, C BLAKELY, WF TI EFFECT OF FISSION-NEUTRON DOSE-RATE ON THE INDUCTION OF A TUMOR-ASSOCIATED ANTIGEN IN HUMAN CELL HYBRIDS (HELA X SKIN FIBROBLASTS) SO RADIATION RESEARCH LA English DT Article ID ENHANCE NEOPLASTIC TRANSFORMATION; SPECTRUM NEUTRONS; ONCOGENIC TRANSFORMATION; INDUCED EXPRESSION; GAMMA-RAYS; RADIATION; IRRADIATION; EXPOSURES; INVITRO; REPAIR C1 USA,RADIOBIOL RES INST,DEPT RADIAT BIOCHEM,BETHESDA,MD 20889. RP REDPATH, JL (reprint author), UNIV CALIF IRVINE,DEPT RADIOL SCI,IRVINE,CA 92717, USA. NR 30 TC 7 Z9 7 U1 0 U2 0 PU RADIATION RESEARCH SOC PI OAK BROOK PA 2021 SPRING RD, STE 600, OAK BROOK, IL 60521 SN 0033-7587 J9 RADIAT RES JI Radiat. Res. PD OCT PY 1991 VL 128 IS 1 SU S BP S71 EP S74 DI 10.2307/3578005 PG 4 WC Biology; Biophysics; Radiology, Nuclear Medicine & Medical Imaging SC Life Sciences & Biomedicine - Other Topics; Biophysics; Radiology, Nuclear Medicine & Medical Imaging GA GK944 UT WOS:A1991GK94400013 PM 1924752 ER PT J AU SHIELS, WE MAVES, CK HEDLUND, GL KIRKS, DR AF SHIELS, WE MAVES, CK HEDLUND, GL KIRKS, DR TI AIR ENEMA FOR DIAGNOSIS AND REDUCTION OF INTUSSUSCEPTION - CLINICAL-EXPERIENCE AND PRESSURE CORRELATES SO RADIOLOGY LA English DT Article DE CHILDREN, GASTROINTESTINAL TRACT; INFANTS, GASTROINTESTINAL TRACT; GASTROINTESTINAL TRACT, INTERVENTIONAL PROCEDURE; INTUSSUSCEPTION ID PNEUMATIC REDUCTION; ILEOCOLIC INTUSSUSCEPTION; CHILDREN AB Air enema was used for exclusion, diagnosis, initial movement, and complete reduction of intussusception in 186 pediatric patients. Average pressure needed for initial movement of intussusception was 56.5 mm Hg; average maximum pressure of 97.8 mm Hg was required for complete reduction. Average fluoroscopy time required for intussusception reduction was 94.8 seconds; an average of 41.8 seconds was required to exclude intussusception. Intussusception was diagnosed in 75 patients, and reduction was accomplished in 65 (87%). Of 100 consecutive patients that underwent hydrostatic reduction of intussusception at the author's institution, reduction was successful in 55. Compared with hydrostatic enema, air enema involves shorter fluoroscopy time and lower radiation dose to the patient. Air enema is safe and effective for diagnosis and treatment of intussusception in infants and children and has replaced hydrostatic enema for such procedures at the authors' institution. C1 UNIV CINCINNATI,COLL MED,DEPT RADIOL,CINCINNATI,OH 45221. UNIV CINCINNATI,COLL MED,DEPT PEDIAT,CINCINNATI,OH 45221. RP SHIELS, WE (reprint author), WALTER REED ARMY MED CTR,DEPT RADIOL HSHL-X,WASHINGTON,DC 20307, USA. NR 10 TC 79 Z9 80 U1 0 U2 1 PU RADIOLOGICAL SOC NORTH AMER PI EASTON PA 20TH AND NORTHAMPTON STS, EASTON, PA 18042 SN 0033-8419 J9 RADIOLOGY JI Radiology PD OCT PY 1991 VL 181 IS 1 BP 169 EP 172 PG 4 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA GF736 UT WOS:A1991GF73600034 PM 1887028 ER PT J AU SARAFIAN, SK CHU, ML KOJIMA, H SNG, EH JOYCE, MP KNAPP, JS AF SARAFIAN, SK CHU, ML KOJIMA, H SNG, EH JOYCE, MP KNAPP, JS TI DISTRIBUTION OF THE 3.05-MDAL TORONTO BETA-LACTAMASE PLASMID AMONG PENICILLINASE-PRODUCING ISOLATES OF NEISSERIA-GONORRHOEAE IN THE FAR-EAST SO SEXUALLY TRANSMITTED DISEASES LA English DT Article ID STRAINS AB One hundred and fifty-two beta-lactamase-producing Neisseria gonorrhoeae isolates from Japan (n = 25; 1983, 1985, 1986), Taiwan (n = 14; 1983, 1984), and the Republics of Singapore (n = 58; 1986, 1987) and the Phillippines (n = 55; 1989) isolated from 1983 through 1989 were characterized by auxotype, serovar, and plasmid content to determine the distribution and diversity of penicillinase-producing N. gonorrhoeae (PPNG) strains possessing the 3.05-Mdal "Toronto" beta-lactamase plasmid. PPNG isolates possessing a 3.05-Mdal beta-lactamase plasmid were isolated in Japan (1/25: 4%), Taiwan (4/14: 29%), and the Republic of the Phillippines (3/55: 5%); no PPNG isolates with the 3.05-Mdal plasmid were isolated in the Republic of Singapore. All isolates possessing the 3.05-Mdal plasmid also possessed a 24.5-Mdal conjugative plasmid and belonged to the auxotype/serovar class, Proto/IB-1. Studies with five isolates possessing the 3.05-Mdal plasmid, and representing isolates from each country in which they were found, confirmed that the beta-lactamase plasmid in these strains could not be transferred to another gonococcal isolate by conjugation. PPNG isolates possessing the "Toronto" plasmid are widespread in the Far East; spread of these isolates may, however, be limited to the physical spread of a single strain. C1 TRISERV GEN HOSP,DEPT MED RES,TAIPEI,TAIWAN. JAPANESE RED CROSS,MED CTR,DEPT UROL,TOKYO,JAPAN. MINIST HLTH,DEPT PATHOL,SINGAPORE,SINGAPORE. BROOKE ARMY MED CTR,DIV INFECT DIS,FT SAM HOUSTON,TX 78234. RP SARAFIAN, SK (reprint author), CTR DIS CONTROL,CTR INFECT DIS,DIV SEXUALLY TRANSMITTED DIS LAB RES,MAILSTOP D-13,ATLANTA,GA 30333, USA. NR 15 TC 7 Z9 7 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0148-5717 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD OCT-DEC PY 1991 VL 18 IS 4 BP 201 EP 204 DI 10.1097/00007435-199110000-00001 PG 4 WC Infectious Diseases SC Infectious Diseases GA GQ726 UT WOS:A1991GQ72600001 PM 1771472 ER PT J AU TENHOLDER, MF PIKE, JD AF TENHOLDER, MF PIKE, JD TI EFFECT OF ANOREXIA-NERVOSA ON PULMONARY IMMUNOCOMPETENCE SO SOUTHERN MEDICAL JOURNAL LA English DT Article ID DISEASE AB Pulmonary infection due to opportunistic organisms and usually nonpathogenic mycobacteria may occur whenever immune defenses are weakened by external factors. These factors include neutropenia, treatment with corticosteroids or cytotoxic agents, previous antibiotic therapy, and nosocomial hazards (eg, catheters. ventilators). Nutritional deprivation is also often implicated as an important coexistent variable. An infection due to Mycobacterium xenopi (usually a nonpathogenic mycobacterium) in a patient with anorexia nervosa and no other predisposing factor for infection provides a model for discussing the possible effects of malnutrition on pulmonary immunocompetence. Since pulmonary infection in anorexia nervosa is often subtle, early evaluation of depressed cell-mediated immunity is appropriate. C1 VET AFFAIRS MED CTR,PULM DIS SERV,AUGUSTA,GA. WALTER REED ARMY MED CTR,CRIT CARE DIS SERV,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 22 TC 13 Z9 13 U1 0 U2 0 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD OCT PY 1991 VL 84 IS 10 BP 1188 EP 1191 DI 10.1097/00007611-199110000-00007 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA GM130 UT WOS:A1991GM13000007 PM 1925716 ER PT J AU HALE, DA SOLLA, JA AF HALE, DA SOLLA, JA TI COMPLETE COLONIC OBSTRUCTION CAUSED BY A SIGMOID COLON CANCER INCARCERATED IN AN INGUINAL-HERNIA SAC SO SOUTHERN MEDICAL JOURNAL LA English DT Note C1 WALTER REED ARMY MED CTR,GEN SURG SERV,COLON & RECTAL SURG SECT,WASHINGTON,DC 20307. NR 15 TC 7 Z9 7 U1 0 U2 0 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD OCT PY 1991 VL 84 IS 10 BP 1280 EP 1281 DI 10.1097/00007611-199110000-00032 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA GM130 UT WOS:A1991GM13000032 PM 1925737 ER PT J AU CHANG, F LEVY, M JACKMAN, B NOWAK, WB AF CHANG, F LEVY, M JACKMAN, B NOWAK, WB TI ASSESSMENT OF CORROSION-RESISTANT COATINGS FOR A DEPLETED URANIUM-0.75 TITANIUM-ALLOY SO SURFACE & COATINGS TECHNOLOGY LA English DT Article AB A number of different coatings (aluminum, zinc, magnesium, Al-Zn, Al-Mg, nickel, titanium, TiN and aluminum on TiN) were applied by the arc plasma physical vapor deposition technique to a depleted uranium (DU) alloy for corrosion protection assessment. The as-deposited specimens were examined by scanning electron microscopy for surface morphology and tested for adhesion. Electrochemical polarization tests and immersion tests were conducted in aerated 3.5 wt.% NaCl solution. The results of the electrochemical polarization scans and observations after long-term exposure tests indicated that the two alloys Al-Zn and Al-Mg appear to be the best sacrificial coating materials for improving the corrosion resistance of DU-0.75Ti. C1 NORTHEASTERN UNIV,BOSTON,MA 02115. RP CHANG, F (reprint author), USA,MAT TECHNOL LAB,WATERTOWN,MA 02172, USA. NR 9 TC 13 Z9 22 U1 0 U2 5 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0257-8972 J9 SURF COAT TECH JI Surf. Coat. Technol. PD OCT 1 PY 1991 VL 48 IS 1 BP 31 EP 39 DI 10.1016/0257-8972(91)90126-H PG 9 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA GK375 UT WOS:A1991GK37500006 ER PT J AU ANDERSON, GW LEE, JO ANDERSON, AO POWELL, N MANGIAFICO, JA MEADORS, G AF ANDERSON, GW LEE, JO ANDERSON, AO POWELL, N MANGIAFICO, JA MEADORS, G TI EFFICACY OF A RIFT-VALLEY FEVER VIRUS-VACCINE AGAINST AN AEROSOL INFECTION IN RATS SO VACCINE LA English DT Article ID HAMSTERS AB The formalin-inactivated Rift Valley fever virus (RVFV) vaccine, TSI-GSD-200, was administered subcutaneously to highly susceptible adult Wistar-Furth rats (LD50-1 p.f.u., ZH501 strain). Vaccine was administered on days 0, 7 and 28, the same time course used for at-risk personnel. Six months postimmunization, when the serum plaque-reduction neutralization titre (PRNT)80 had declined to low or undetectable levels, rats were challenged with 4.4 log10 p.f.u. of the virulent ZH501 strain in a nose-only dynamic aerosol apparatus. Ninety-seven per cent (33/34) of the non-vaccinated control rats died. In contrast, only 32% (33/105) of the vaccinated animals died. In vaccinated rats that succumbed, there was a doubling of the mean time to death and the cause of death shifted from hepatitis to encephalitis. Rats with a PRNT80 of greater-than-or-equal-to 1:40 were protected from clinical disease and histological evidence of hepatic or encephalitic lesions. While the precise mechanisms of immunity against aerosol challenge remain unresolved, here the serum PRNT titre correlated with protection. C1 USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FREDERICK,MD 21701. USA,MED RES INST INFECT DIS,DIV ANIM RESOURCES,FREDERICK,MD 21701. USA,MED RES INST INFECT DIS,DIV BIOMETR & INFORMAT,FREDERICK,MD 21701. NR 27 TC 25 Z9 26 U1 0 U2 2 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PD OCT PY 1991 VL 9 IS 10 BP 710 EP 714 DI 10.1016/0264-410X(91)90285-E PG 5 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA GH044 UT WOS:A1991GH04400003 PM 1759489 ER PT J AU JOHNSON, MJE SLIFE, DM ANDERS, GT BAILEY, SR BLANTON, HM MCALLISTER, CK LATHAM, RD AF JOHNSON, MJE SLIFE, DM ANDERS, GT BAILEY, SR BLANTON, HM MCALLISTER, CK LATHAM, RD TI CARDIAC DYSFUNCTION IN PATIENTS SEROPOSITIVE FOR THE HUMAN-IMMUNODEFICIENCY-VIRUS SO WESTERN JOURNAL OF MEDICINE LA English DT Article ID IMMUNE-DEFICIENCY SYNDROME; CONGESTIVE CARDIOMYOPATHY; SYNDROME AIDS; INFECTION; MYOCARDITIS; ASSOCIATION; HIV AB To confirm the presence of cardiac dysfunction in a group of patients seropositive for the human immunodeficiency virus with either dyspnea on exertion or a reduced anaerobic threshold, 9 patients with no history of opportunistic infection underwent exercise right-sided heart catheterization. When compared with 13 control patients previously exercised in the same manner, the patients showed elevated exercise pulmonary capillary wedge pressure (14.6 +/- 3.3 mm of mercury versus 9.9 +/- 3.3 mm of mercury; P < .005) and right atrial pressure (10.1 +/- 2.1 mm of mercury versus 4.7 +/- 3.2 mm of mercury; P < .001) at a similar exercise oxygen consumption and cardiac index. Of the 9 patients, 8 had at least 1 catheterization value outside the 95% confidence limits for the control group and 4 patients had multiple abnormalities. Values for blood CD4 lymphocytes were 0.2 x 10(9) per liter or more for 7 of the 9. One patient underwent endomyocardial biopsy with findings consistent with a cardiomyopathy. We conclude that cardiac disease may occur at any immunologic stage of human immunodeficiency virus infection. These observations suggest an effect of this disease on the heart. C1 BROOKE ARMY MED CTR,PULM DIS CRIT CARE SERV,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,CARDIOL SERV,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,INFECT DIS SERV,FT SAM HOUSTON,TX 78234. NR 28 TC 3 Z9 3 U1 0 U2 0 PU CALIFORNIA PHYSICIAN MAGAZINE PI SAN FRANCISCO PA C/O DONNA TAYLOR, EDITOR, PO BOX 7690, SAN FRANCISCO, CA 94102-7690 SN 0093-0415 J9 WESTERN J MED JI West. J. Med. PD OCT PY 1991 VL 155 IS 4 BP 373 EP 379 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA GK557 UT WOS:A1991GK55700003 ER PT J AU YEUNG, AS FRANK, CW SINGLER, RE AF YEUNG, AS FRANK, CW SINGLER, RE TI EXCIMER FLUORESCENCE IN POLYPHOSPHAZENES .2. MORPHOLOGY AND DYNAMICS IN POLYMER-FILMS SO MACROMOLECULES LA English DT Article ID THERMAL TRANSITION BEHAVIOR; X-RAY; PHASE-TRANSITIONS; SOLID-STATE; POLY; POLY; POLY(DIFLUOROPHOSPHAZENE); DIFFRACTION; RELAXATION; COPOLYMERS AB The effects of substituent on morphology and fluorescence behavior in poly(organophosphazenes) are studied. Side-group and main-chain motions in two representative poly[(aryloxy)phosphazenes], poly(diphenoxyphosphazene) (PBPP) and poly(di-p-cresoxyphosphazene) (PBCP), are investigated along with a copolymer, poly[(trifluoroethoxy)phenoxyphosphazene] (PFPP) in both amorphous and crystalline phases in terms of the excimer-to-monomer intensity ratio, I(D)/I(M), excimer bandwidth, and excimer band position. The glass transition temperature, T(g), and mesomorphic temperature, T(1), obtained by differential scanning calorimetry, correlate well with transitions observed in I(D)/I(M) and excimer bandwidth measurements. Multiple excimer-forming sites are found in all polymers, especially in PFPP where isomorphic forms of monoclinic and orthorhombic structures are found. A comparison of fluorescene spectra from solutions and the bulk phase yields qualitative assignments of the excimer bands, whereas the fluorescence spectra for annealed PBPP and PBCP films illustrate the effect of crystal structure. In PBPP, the transformation of the alpha-form to the beta-form of the monoclinic crystal structure upon annealing does not increase the overall excimer emission but causes a blue shift in the composite excimer band. By contrast, the transformation of the alpha-form to the gamma-form of the orthorhombic structure in PBCP results in an increase in excimer emission as well as a red shift of the excimer band. The increase in excimer emission in PBCP upon annealing below T(1) suggests that the orthorhombic structure is more conducive to excimer formation. C1 STANFORD UNIV,DEPT CHEM ENGN,STANFORD,CA 94305. USA,MAT & MECH RES CTR,DIV POLYMER RES,WATERTOWN,MA 02172. NR 44 TC 5 Z9 5 U1 1 U2 8 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD SEP 30 PY 1991 VL 24 IS 20 BP 5539 EP 5545 DI 10.1021/ma00020a010 PG 7 WC Polymer Science SC Polymer Science GA GH467 UT WOS:A1991GH46700010 ER PT J AU RICE, BM CHABALOWSKI, CF ADAMS, GF MOWREY, RC PAGE, M AF RICE, BM CHABALOWSKI, CF ADAMS, GF MOWREY, RC PAGE, M TI A COMPARATIVE-STUDY OF THE REACTION DYNAMICS OF A MODEL SYSTEM USING DIFFERENT CRITERIA IN PARAMETERIZING THE POTENTIAL-ENERGY FUNCTION SO CHEMICAL PHYSICS LETTERS LA English DT Article ID MOLECULAR DIPOLE-MOMENT; ATOMIC POINT CHARGES; 2ND DERIVATIVES; CARTESIAN DERIVATIVES; PLANAR DIMERS; MECHANICS AB A comparative study of the reaction dynamics of a model system using a potential energy function that has been parameterized according to two different criteria is presented. The molecule studied is methylene nitramine, CH2NNO2, and the reaction studied is the N-N bond scission reaction. A mathematical description of the potential energy surface for the system was developed, and parameters for the individual terms in the model were fitted to data obtained from ab initio computations. The first model was fitted to the Cartesian second derivatives of the energy for equilibrium methylene nitramine, while the second model was fitted using the computed harmonic frequencies for the molecule. Unimolecular decay curves for the N-N bond scission reaction were computed at six energies between 2.9384 and 4.1884 eV. Not only do the two models disagree in the computed reaction rates, but the rates predicted by model I are first order and time independent while those obtained with model II indicate erratic and non-statistical behavior. This study shows the sensitivity of dynamics calculations to quantitative differences in potential energy surfaces fitted to different aspects of electronic structure calculations. C1 USN,RES LAB,WASHINGTON,DC 20375. RP RICE, BM (reprint author), USA,BALLIST RES LABS,SLCBR 1B1,ABERDEEN PROVING GROUND,MD 21005, USA. NR 16 TC 9 Z9 9 U1 2 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD SEP 27 PY 1991 VL 184 IS 4 BP 335 EP 342 DI 10.1016/0009-2614(91)85133-H PG 8 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA GJ241 UT WOS:A1991GJ24100016 ER PT J AU FOWLER, WK STEWART, DC WEINBERG, DS SARVER, EW AF FOWLER, WK STEWART, DC WEINBERG, DS SARVER, EW TI GAS-CHROMATOGRAPHIC DETERMINATION OF THE LEWISITE HYDROLYSATE, 2-CHLOROVINYLARSONOUS ACID, AFTER DERIVATIZATION WITH 1,2-ETHANEDITHIOL SO JOURNAL OF CHROMATOGRAPHY LA English DT Article AB The primary hydrolysate of the toxic military agent lewisite (2-chlorovinylarsonous acid, or CVA) can be determined in trace concentrations by gas chromatography with flame-photometric detection after the CVA has been derivatized with 1,2-ethanedithiol to form a stable cyclic disulfide. The method has been shown to be applicable to the analysis of water samples that contain CVA in low ppb (10(9)) concentrations. In addition, the method was demonstrated to be at least potentially useful for lewisite vapor determinations in air at sub-ppb levels in situations where any CVA found in the sampler can be assumed to have been formed from lewisite. Relative to the other procedures that are available for determining lewisite or CVA, this procedure is more sensitive, more specific for the analyte or simpler to perform. C1 USA,ARMAMENT MUNIT & CHEM COMMAND,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. RP FOWLER, WK (reprint author), SO RES INST,POB 55305,BIRMINGHAM,AL 35255, USA. NR 8 TC 35 Z9 37 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0021-9673 J9 J CHROMATOGR PD SEP 27 PY 1991 VL 558 IS 1 BP 235 EP 246 DI 10.1016/0021-9673(91)80129-5 PG 12 WC Chemistry, Analytical SC Chemistry GA GK089 UT WOS:A1991GK08900024 ER PT J AU RICHARDS, AL HYAMS, KC MERRELL, BR DASCH, GA WOODY, JN KSIAZEK, TG LEDUC, JW WATTS, DM AF RICHARDS, AL HYAMS, KC MERRELL, BR DASCH, GA WOODY, JN KSIAZEK, TG LEDUC, JW WATTS, DM TI MEDICAL ASPECTS OF OPERATION DESERT STORM SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter C1 USN,MED RES & DEV COMMAND,BETHESDA,MD 20889. USA,MED RES INST INFECT DIS,FT DETRICK,MD 21702. USN,MED RES UNIT 3,CAIRO,EGYPT. RP RICHARDS, AL (reprint author), USN,INST MED RES,WASHINGTON,DC 20350, USA. NR 3 TC 10 Z9 10 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD SEP 26 PY 1991 VL 325 IS 13 BP 970 EP 970 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA GF856 UT WOS:A1991GF85600032 ER PT J AU BLANCK, RR BELL, WH AF BLANCK, RR BELL, WH TI MEDICAL ASPECTS OF OPERATION DESERT STORM - REPLY SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter RP BLANCK, RR (reprint author), USA,FALLS CHURCH,VA 22041, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD SEP 26 PY 1991 VL 325 IS 13 BP 971 EP 971 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA GF856 UT WOS:A1991GF85600036 ER PT J AU CHOI, KK TAYSINGLARA, M FOTIADIS, L CHANG, W IAFRATE, GJ AF CHOI, KK TAYSINGLARA, M FOTIADIS, L CHANG, W IAFRATE, GJ TI PHOTOVOLTAGE AMPLIFICATION AND QUASI-PHOTOVOLTAIC OPERATION OF AN INFRARED HOT-ELECTRON TRANSISTOR SO APPLIED PHYSICS LETTERS LA English DT Article ID DETECTOR AB Under proper external bias, we showed that photovoltage amplification can be achieved from an infrared hot-electron transistor, and hence the transistor structure can be used to increase the voltage responsivity of a multiple quantum well photoconductor. In addition, the output voltage of the transistor can be very small when there is no signal light source, similar to a photovoltaic detector. As a result, the transistor is able to dc couple to a high-gain voltage amplifier for further signal amplification without reducing its detectivity. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP CHOI, KK (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. RI Choi, Kwong-Kit/K-9205-2013 NR 9 TC 3 Z9 3 U1 1 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD SEP 23 PY 1991 VL 59 IS 13 BP 1614 EP 1616 DI 10.1063/1.106247 PG 3 WC Physics, Applied SC Physics GA GG105 UT WOS:A1991GG10500033 ER PT J AU PEROVICH, DK GOW, AJ AF PEROVICH, DK GOW, AJ TI A STATISTICAL DESCRIPTION OF THE MICROSTRUCTURE OF YOUNG SEA ICE SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID OPTICAL-PROPERTIES; MEDIA AB In order to fully exploit microwave models of sea ice, the standard ice characterization must be supplemented by a statistical description of the ice microstructure. For the strong fluctuation theory this statistical description takes the form of the mean and variance of the permittivity plus correlation lengths. We have computed these statistics for over 50 samples of young ice, including both columnar congelation ice and desalinated bubbly ice. Samples were taken from different vertical depths and horizontal positions within the ice sheet and encompassed a comprehensive range of ice temperatures and brine volumes. For each of these samples, horizontal thin sections were photographed, then digitized and analyzed on a personal computer-based image processing system. Results indicate that correlation lengths correspond to the physical dimensions of the inclusions: the brine pocket size (typically tenths of a millimeter) for saline ice and the air bubble size (typically millimeters) for desalinated ice. For saline ice the shape of the correlation function was elliptical, similar to the shape of the brine pockets. In one case as the ice warmed from -20-degrees to -1-degrees-C and the brine volume increased from 2 to 37%, the correlation length increased from 0.14 to 0.22 mm. RP PEROVICH, DK (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 23 TC 26 Z9 26 U1 0 U2 3 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0148-0227 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD SEP 15 PY 1991 VL 96 IS C9 BP 16943 EP 16953 DI 10.1029/91JC01594 PG 11 WC Oceanography SC Oceanography GA GG239 UT WOS:A1991GG23900020 ER PT J AU FRIEDMAN, RS TRUHLAR, DG AF FRIEDMAN, RS TRUHLAR, DG TI CHEMICAL-REACTION THRESHOLDS ARE RESONANCES SO CHEMICAL PHYSICS LETTERS LA English DT Article ID TUNNELING CALCULATIONS; REACTION PROBABILITIES; LIFETIME ANALYSIS; RATE CONSTANTS; SCATTERING; MATRIX; STATES AB We show that passage over a potential barrier is associated with a pole of the scattering (S) matrix. Thus reaction thresholds associated with barriers are described in quantum mechanics by poles of the scattering matrix, i.e. chemical reaction thresholds are resonances. Furthermore, by varying the parameters of a potential energy function, such a pole may be transformed continuously into a conventional resonance associated with a particle trapped in a well between barriers. Thus there is no distinction in kind between the poles corresponding to the two physical phenomena. Trapped state resonances though tend to be narrower than barrier resonances. C1 UNIV MINNESOTA,USA,HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55455. RP FRIEDMAN, RS (reprint author), UNIV MINNESOTA,INST SUPERCOMP,DEPT CHEM,MINNEAPOLIS,MN 55455, USA. RI Truhlar, Donald/G-7076-2015 OI Truhlar, Donald/0000-0002-7742-7294 NR 30 TC 79 Z9 80 U1 0 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD SEP 13 PY 1991 VL 183 IS 6 BP 539 EP 546 DI 10.1016/0009-2614(91)80172-T PG 8 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA GF961 UT WOS:A1991GF96100013 ER PT J AU TRAMONT, EC BURKE, DS REDFIELD, RR AF TRAMONT, EC BURKE, DS REDFIELD, RR TI RESPONDING TO THE AIDS EPIDEMIC SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter RP TRAMONT, EC (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 2 TC 1 Z9 1 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD SEP 12 PY 1991 VL 325 IS 11 BP 809 EP 809 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA GE456 UT WOS:A1991GE45600014 ER PT J AU CRENSHAW, ME BOWDEN, CM AF CRENSHAW, ME BOWDEN, CM TI SPECTRAL RESPONSE AND PROPAGATIONAL INSTABILITY FOR PUMP-PROBE PROPAGATION IN A 2-LEVEL MEDIUM SO PHYSICAL REVIEW LETTERS LA English DT Article ID LIGHT; AMPLIFICATION; EMISSION; EQUATION; SYSTEM AB The interaction of a strong nearly resonant cw pump laser and a weak cw probe laser in a medium consisting of two-level atoms was studied by numerical integration of the Maxwell-Bloch equations. With propagation into the optically thick medium, the numerically calculated probe gain spectrum deviates substantially from one calculated by a four-wave-mixing formulation of coupled-wave theory with an undepleted pump. For probe frequencies inside the modified gain region, the laser field, initially in an unstable steady-state condition, evolves to a stable solution of the sine-Gordon equation. RP CRENSHAW, ME (reprint author), USA,WEAPONS SCI DIRECTORATE,AMSMI RD WS RES DEV & ENGN CTR,REDSTONE ARSENAL,AL 35809, USA. NR 14 TC 6 Z9 6 U1 0 U2 1 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD SEP 2 PY 1991 VL 67 IS 10 BP 1226 EP 1229 DI 10.1103/PhysRevLett.67.1226 PG 4 WC Physics, Multidisciplinary SC Physics GA GC957 UT WOS:A1991GC95700013 ER PT J AU BRITSCH, LD DUNBAR, JB KEMP, EB AF BRITSCH, LD DUNBAR, JB KEMP, EB TI DETERMINATION OF LAND-LOSS RATES IN COASTAL LOUISIANA SO AAPG BULLETIN-AMERICAN ASSOCIATION OF PETROLEUM GEOLOGISTS LA English DT Meeting Abstract C1 USA,NEW ORLEANS,LA. USA,CORPS ENGINEERS,WATERWAY EXPT STN,VICKSBURG,MS 39180. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER ASSN PETROL GEOLOGISTS PI TULSA PA 1444 S BOULDER AVE PO BOX 979, TULSA, OK 74101 SN 0149-1423 J9 AAPG BULL JI AAPG Bull.-Am. Assoc. Petr. Geol. PD SEP PY 1991 VL 75 IS 9 BP 1516 EP 1517 PG 2 WC Geosciences, Multidisciplinary SC Geology GA GD155 UT WOS:A1991GD15500020 ER PT J AU HEINRICH, PV AF HEINRICH, PV TI A SEDIMENTOLOGICAL EXPLANATION FOR THE DISTRIBUTION OF ARCHAEOLOGICAL SITES IN A MEANDER-BELT AS STATED BY THE RELICT CHANNEL RULE SO AAPG BULLETIN-AMERICAN ASSOCIATION OF PETROLEUM GEOLOGISTS LA English DT Meeting Abstract C1 USA,CORPS ENGINEERS,BATON ROUGE,LA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER ASSN PETROL GEOLOGISTS PI TULSA PA 1444 S BOULDER AVE PO BOX 979, TULSA, OK 74101 SN 0149-1423 J9 AAPG BULL JI AAPG Bull.-Am. Assoc. Petr. Geol. PD SEP PY 1991 VL 75 IS 9 BP 1524 EP 1525 PG 2 WC Geosciences, Multidisciplinary SC Geology GA GD155 UT WOS:A1991GD15500052 ER PT J AU SAUNDERS, JA HARRELSON, DW AF SAUNDERS, JA HARRELSON, DW TI AGE AND PETROLOGY OF THE JACKSON DOME IGNEOUS-VOLCANIC COMPLEX, MISSISSIPPI - IMPLICATIONS FOR THE TECTONIC HISTORY OF THE MISSISSIPPI SALT-DOME BASIN SO AAPG BULLETIN-AMERICAN ASSOCIATION OF PETROLEUM GEOLOGISTS LA English DT Meeting Abstract C1 UNIV MISSISSIPPI,UNIVERSITY,MS 38677. USA,CORPS ENGINEERS,VICKSBURG,MS 39180. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER ASSN PETROL GEOLOGISTS PI TULSA PA 1444 S BOULDER AVE PO BOX 979, TULSA, OK 74101 SN 0149-1423 J9 AAPG BULL JI AAPG Bull.-Am. Assoc. Petr. Geol. PD SEP PY 1991 VL 75 IS 9 BP 1538 EP 1538 PG 1 WC Geosciences, Multidisciplinary SC Geology GA GD155 UT WOS:A1991GD15500096 ER PT J AU TRUWIT, CL BARKOVICH, AJ SHANAHAN, R MAROLDO, TV AF TRUWIT, CL BARKOVICH, AJ SHANAHAN, R MAROLDO, TV TI MR IMAGING OF RHOMBENCEPHALOSYNAPSIS - REPORT OF 3 CASES AND REVIEW OF THE LITERATURE SO AMERICAN JOURNAL OF NEURORADIOLOGY LA English DT Article ID CEREBELLAR VERMIS APLASIA; DANDY-WALKER SYNDROME; UNCOMMON SYNDROMES; JOUBERT SYNDROME; AGENESIS; HEMISPHERES; APPEARANCE; ANOMALIES; FUSION; NUCLEI AB We describe the clinical and MR findings in three cases of rhombencephalosynapsis, a rare congenital malformation of the posterior fossa consisting of vermian agenesis or severe hypogenesis, fusion of the cerebellar hemispheres, and apposition or fusion of the dentate nuclei. Associated anomalies include hydrocephalus, fusion of the inferior colliculi, deficiency or absence of the septum pellucidum, and hypoplasia of the anterior commissure. Fourteen previous cases of rhombencephalosynapsis have been reported, including Obersteiner's first report in 1914. The clinical presentation is variable, ranging from early death to variable degrees of cerebellar dysfunction and developmental delay. Patients may reach young adulthood. We report three additional cases and provide radiographic (MR) images of this unusual anomaly detected during life. Diagnoses in three children with rhombencephalosynapsis were made on the basis of MR findings. To our knowledge, this is the first report of this disorder being diagnosed in living patients. C1 UNIV CALIF SAN FRANCISCO,DEPT RADIOL,NEURORADIOL SECT,SAN FRANCISCO,CA 94143. OAKLAND CHILDRENS MED CTR,DEPT NEUROL,OAKLAND,CA 94609. USA,DEPT MED,ACAD HLTH SCI,FT SAM HOUSTON,TX 78234. RP TRUWIT, CL (reprint author), FITZSIMONS ARMY MED CTR,DEPT RADIOL,AURORA,CO 80045, USA. NR 26 TC 80 Z9 80 U1 0 U2 0 PU AMER SOC NEURORADIOLOGY PI OAK BROOK PA 2210 MIDWEST RD, OAK BROOK, IL 60521 SN 0195-6108 J9 AM J NEURORADIOL JI Am. J. Neuroradiol. PD SEP-OCT PY 1991 VL 12 IS 5 BP 957 EP 965 PG 9 WC Clinical Neurology; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA GD555 UT WOS:A1991GD55500030 PM 1950929 ER PT J AU KEELER, R SATO, AK CLAYBAUGH, JR WILSON, N AF KEELER, R SATO, AK CLAYBAUGH, JR WILSON, N TI EFFECT OF V2 ANTAGONIST ON CLEARANCE OF ARGININE VASOPRESSIN BY ISOLATED PERFUSED RAT KIDNEYS SO AMERICAN JOURNAL OF PHYSIOLOGY LA English DT Article DE PERFUSED KIDNEY ID INACTIVATION; TRANSPORT; MECHANISM; OXYTOCIN; URINARY; DOGS; AVP; PIG AB Isolated rat kidneys were perfused with Krebs-Henseleit-bovine serum albumin solution at a mean pressure of 99 +/- 2.6 mmHg. After control periods, arginine vasopressin (AVP) was added to the perfusate at a final calculated concentration of 25 pg/ml (2.5 x 10(-11) M). Urine and perfusate samples were collected at 15-min intervals for the following 60 min to measure kidney function and the renal clearance of immunoreactive AVP (irAVP). At 15-30 min after the addition of AVP, total renal clearance of irAVP was 1,623 +/- 190-mu-l.min-1.g kidney wt-1. Glomerular filtration accounted for 35 +/- 3.0% of the total clearance, and 65 +/- 10.3% was cleared by peritubular pathways. Of the filtered irAVP, 48 +/- 4.8% was recovered in the urine. To investigate the importance of V2 receptors in the metabolism of AVP, clearance measurements were made in the presence of the V2 antagonist [d(CH2)5,D-Ile2,Ile4,Arg8]AVP (5 x 10(-9) M). Total renal clearance of irAVP was reduced by 48% to 848 +/- 79-mu-l.min-1.g-1. This reduction was entirely accounted for by the complete inhibition of peritubular clearance of irAVP. In the presence of the V2 antagonist, irAVP was cleared only by filtration. The proportion of filtered AVP recovered in the urine (53 +/- 8.7%) was not significantly altered by the presence of the V2 antagonist. We conclude that a major component of the renal clearance of AVP depends on receptor-mediated uptake of AVP in the kidney cells. C1 TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96859. RP KEELER, R (reprint author), UNIV BRITISH COLUMBIA,FAC MED,DEPT PHYSIOL,2146 HLTH SCI MALL,VANCOUVER V6T 1W5,BC,CANADA. NR 21 TC 7 Z9 7 U1 0 U2 1 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0002-9513 J9 AM J PHYSIOL JI Am. J. Physiol. PD SEP PY 1991 VL 261 IS 3 BP R665 EP R669 PN 2 PG 5 WC Physiology SC Physiology GA GE638 UT WOS:A1991GE63800070 PM 1887953 ER PT J AU LAGUTCHIK, MS JANUSZKIEWICZ, AJ DODD, KT MARTIN, DG AF LAGUTCHIK, MS JANUSZKIEWICZ, AJ DODD, KT MARTIN, DG TI CARDIOPULMONARY EFFECTS OF A TILETAMINE-ZOLAZEPAM COMBINATION IN SHEEP SO AMERICAN JOURNAL OF VETERINARY RESEARCH LA English DT Article ID FENTANYL-DROPERIDOL DROPERIDOL; ADULT MALE-RATS; KETAMINE-XYLAZINE; DIAZEPAM-KETAMINE; LABORATORY-ANIMALS; ANESTHESIA; DOGS; WILD; INDUCTION AB To assess the effects on heart and lung function, a tiletamine-zolazepam (TZ) anesthetic combination was evaluated in 10 Dorset-type ewes. Ewes were randomly allotted to 2 equal groups. Ewes of groups 1 and 2 were given a single bolus of TZ (12 and 24 mg/kg of body weight, IV, respectively) at time zero. Hemodynamic, pulmonary, and ventilation variables were measured at 15-minute intervals to 120 minutes. Blood gas variables were evaluated at 5-minute intervals for the first 30 minutes, then at 15-minute intervals to 120 minutes. In all sheep, TZ administration induced rapid, smooth induction, with gradual and unremarkable recovery. Anesthesia duration was not significantly different between groups (mean +/- SD, 39 +/- 5 and 40 +/- 14 minutes for groups 1 and 2, respectively). Immediate drug effects included apnea, decreased mean arterial blood pressure, and arterial hypoxemia. Cardiac output was significantly decreased in both groups at all times after drug administration. Significant changes in group-1 ewes included increased pulmonary and systemic vascular resistances and decreased inspired minute ventilation, tidal volume, and respiratory airflow. Significant changes in group-2 ewes included increased systemic vascular resistance and decreased pulmonary arterial pressure, inspired minute ventilation, and respiratory airflow. Both drug dosages induced apneustic breathing patterns and caused significant changes in arterial and venous blood hemoglobin concentrations and PCV. Tile-tamine-zolazepam is useful for intermediate-duration anesthesia in sheep. However, because of alterations in cardiopulmonary function, its use at the dosages evaluated by us is not recommended in studies, in which minimal effects on heart and lung function are required, or in sheep with compromised heart or lung function. C1 WALTER REED ARMY MED CTR,DIV MED,RESP RES BRANCH,WASHINGTON,DC 20307. NR 36 TC 17 Z9 17 U1 0 U2 0 PU AMER VETERINARY MEDICAL ASSOC PI SCHAUMBURG PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 SN 0002-9645 J9 AM J VET RES JI Am. J. Vet. Res. PD SEP PY 1991 VL 52 IS 9 BP 1441 EP 1447 PG 7 WC Veterinary Sciences SC Veterinary Sciences GA GD168 UT WOS:A1991GD16800010 PM 1952330 ER PT J AU DUCEY, JP FINCHER, CW BAYSINGER, CL AF DUCEY, JP FINCHER, CW BAYSINGER, CL TI THERAPEUTIC SUPPRESSION OF A PERMANENT VENTRICULAR PACEMAKER USING A PERIPHERAL-NERVE STIMULATOR SO ANESTHESIOLOGY LA English DT Article DE EQUIPMENT, PACEMAKER; ELECTROCAUTERY; HEART, PACEMAKER ID ELECTROCAUTERY RP DUCEY, JP (reprint author), BROOKE ARMY MED CTR,DEPT SURG,ANESTHESIOL SERV,FT SAM HOUSTON,TX 78234, USA. NR 14 TC 6 Z9 6 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD SEP PY 1991 VL 75 IS 3 BP 533 EP 536 DI 10.1097/00000542-199109000-00025 PG 4 WC Anesthesiology SC Anesthesiology GA GD699 UT WOS:A1991GD69900025 PM 1888062 ER PT J AU PHILLIPS, RW MOSES, FM AF PHILLIPS, RW MOSES, FM TI SUNFLOWER SEED SYNDROME - A PRICKLY PROTOCOLOGICAL PROBLEM SO ANNALS OF EMERGENCY MEDICINE LA English DT Letter RP PHILLIPS, RW (reprint author), WALTER REED ARMY MED CTR,GASTROENTEROL SERV,WASHINGTON,DC 20307, USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD SEP PY 1991 VL 20 IS 9 BP 1049 EP 1049 DI 10.1016/S0196-0644(05)83000-8 PG 1 WC Emergency Medicine SC Emergency Medicine GA GD353 UT WOS:A1991GD35300029 PM 1877779 ER PT J AU CIOFFI, WG VAUGHAN, GM HEIRONIMUS, JD JORDAN, BS MASON, AD PRUITT, BA AF CIOFFI, WG VAUGHAN, GM HEIRONIMUS, JD JORDAN, BS MASON, AD PRUITT, BA TI DISSOCIATION OF BLOOD-VOLUME AND FLOW IN REGULATION OF SALT AND WATER-BALANCE IN BURN PATIENTS SO ANNALS OF SURGERY LA English DT Article; Proceedings Paper CT 111TH ANNUAL MEETING OF THE AMERICAN SURGICAL ASSOC CY APR 11-13, 1991 CL BOCA RATON, FL SP AMER SURG ASSOC ID ATRIAL-NATRIURETIC-FACTOR; BODY-SURFACE AREA; ANGIOTENSIN-II; VASOPRESSIN SECRETION; ALDOSTERONE; PRESSURE; HORMONE; RELEASE; INJURY AB The relationship between effective blood volume and related hormones in burn patients following resuscitation is not well understood. Previous reports have suggested that hormone secretion is altered by a resetting of neural control mechanisms. Serum and urine sodium, plasma renin activity, serum ADH, cardiac index, effective renal plasma flow, and total blood volume were measured in seven burn patients (mean age, total burn size, and postburn day: 32 years, 56%, and 9 days, respectively). The same values (with the exception of cardiac index and blood volume) were measured in 10 control patients (mean age, 24 years). The blood volume of patients was measured by chromium-51 red blood cell (RBC) labeling and compared to normal predicted values based on body surface area and sex. Mean serum sodium and osmolality were 138 mmol/L (millimolar) and 286 mosm/kg, respectively, in both patients and control subjects. Mean +/- standard error of the mean total blood volume in the patients was low, 81% +/- 4% of predicted values. Cardiac index and renal plasma flow were significantly elevated. Plasma renin activity and antidiuretic hormone (ADH) levels were elevated and altered in the direction expected from blood volume measurements despite the findings of increased blood flow. Dissociation of organ flow and hormonal response suggests that simultaneous direct blood volume measurements are necessary to elucidate factors other than altered neural control settings to explain hormonal changes in the flow phase of injury. Depressed total blood volume appears to promote elevated ADH levels in burn patients following resuscitation. Whether there is an additional role of altered neural control settings remains to be established. RP CIOFFI, WG (reprint author), USA,INST SURG RES,LIB BRANCH,BLDG 2653,FT SAM HOUSTON,TX 78234, USA. NR 28 TC 9 Z9 9 U1 0 U2 2 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-4932 J9 ANN SURG JI Ann. Surg. PD SEP PY 1991 VL 214 IS 3 BP 213 EP 220 DI 10.1097/00000658-199109000-00004 PG 8 WC Surgery SC Surgery GA GF813 UT WOS:A1991GF81300004 PM 1656902 ER PT J AU SARGENT, LA SEYFER, AE HOLLINGER, J HINSON, RM GRAEBER, GM AF SARGENT, LA SEYFER, AE HOLLINGER, J HINSON, RM GRAEBER, GM TI THE HEALING STERNUM - A COMPARISON OF OSSEOUS HEALING WITH WIRE VERSUS RIGID FIXATION SO ANNALS OF THORACIC SURGERY LA English DT Article ID MEDIAN STERNOTOMY; DEHISCENCE AB Although median sternotomy is used for most cardiac procedures, postoperative dehiscence remains a serious and persistent problem. This investigation was designed to assess new bone formation and sternal healing across the linear osteotomy of the sternum and to determine if rigid fixation would enhance bony healing and thus decrease unfavorable sequelae. To test this hypothesis, 14 skeletally mature baboons (Papio anubis) underwent standard median sternotomy; seven sternotomies were closed with interrupted 24-gauge cerclage wires, and seven, with thin Vitallium compression miniplates and transverse lag screws. The sterna from each group were harvested en bloc at 4 and 8 weeks, radiographed, processed, and serially sectioned and stained for histomorphometry to assess the quantity of new bone across the linear osteotomy. Clinical stability was superior with the plated and lag screw group at 4 weeks; however, by 8 weeks, no clinical difference between treatments was apparent. Histomorphometric analysis indicated that the linear osteotomy gap treated with plates and screws was less than the gap associated with the wire group. Rigid fixation of the sternum resulted in earlier union with primary osseous healing, suggesting greater inherent stability. These factors may decrease adverse sequelae for this procedure. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,PLAST SURG SERV,DIV SURG,WASHINGTON,DC 20307. USA,WASHINGTON,DC 20310. NR 25 TC 36 Z9 37 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0003-4975 J9 ANN THORAC SURG JI Ann. Thorac. Surg. PD SEP PY 1991 VL 52 IS 3 BP 490 EP 494 PG 5 WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery SC Cardiovascular System & Cardiology; Respiratory System; Surgery GA GG679 UT WOS:A1991GG67900012 PM 1898136 ER PT J AU VAUGHAN, TK SPERLING, LC AF VAUGHAN, TK SPERLING, LC TI DIAGNOSIS AND SURGICAL-TREATMENT OF CONGENITAL CARTILAGINOUS RESTS OF THE NECK SO ARCHIVES OF DERMATOLOGY LA English DT Note RP VAUGHAN, TK (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 4 TC 6 Z9 6 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD SEP PY 1991 VL 127 IS 9 BP 1309 EP 1310 DI 10.1001/archderm.127.9.1309 PG 2 WC Dermatology SC Dermatology GA GF529 UT WOS:A1991GF52900002 PM 1892401 ER PT J AU DILLARD, TA BENINATI, WA BERG, BW AF DILLARD, TA BENINATI, WA BERG, BW TI AIR-TRAVEL IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY-DISEASE SO ARCHIVES OF INTERNAL MEDICINE LA English DT Article ID FLIGHT MEDICAL EMERGENCIES AB Air travel exposes patients with chronic obstructive pulmonary disease to the risk of severe hypoxemia. We sought to determine the frequency and outcome of airline travel in patients with chronic obstructive pulmonary disease. A cohort of 100 patients (76 men and 24 women; age 67 +/- 7 years [mean +/- SD]) with severe chronic pulmonary obstructive disease examined by means of spirometry (forced expiratory volume in the first second, 0.94 +/- 0.35 L), all military retirees, or their dependents, comprised the study population. Forty-four patients traveled by commercial air carrier over a 28-month interval, giving an annual frequency of 18.9% of these patients per year. The group that did not travel by air (n = 56) had a lower mean value for forced expiratory volume in the first second and greater prevalence of home oxygen use than did the group that did travel by air. Twelve of the travelers (27.3%) consulted a physician beforehand. Flights reached foreign destinations for 22.7% of patients. The median duration of the longest flight segment was 3 hours. A minority of patients (34.3%) occupied seats in the smoking sections of aircraft. A majority (56.8 %) ambulated aboard the aircraft during flights. Eight patients (18.2 %) reported transient symptoms during air travel. We conclude that patients with chronic obstructive pulmonary disease travel with appreciable frequency, often without medical consultation, and develop symptoms in some cases. C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP DILLARD, TA (reprint author), WALTER REED ARMY MED CTR,DEPT MED,PULM FUNCT LAB,WASHINGTON,DC 20307, USA. NR 16 TC 31 Z9 32 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD SEP PY 1991 VL 151 IS 9 BP 1793 EP 1795 DI 10.1001/archinte.151.9.1793 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA GE534 UT WOS:A1991GE53400015 PM 1888245 ER PT J AU PERRY, S GRIFFITH, J WHITE, T AF PERRY, S GRIFFITH, J WHITE, T TI RETENTION OF JUNIOR ENLISTED SOLDIERS IN THE ALL-VOLUNTEER ARMY RESERVE SO ARMED FORCES & SOCIETY LA English DT Article AB The Army Reserve loses approximately 30 percent of its personnel annually. Most of these losses are junior enlisted who do not complete their initial service obligation. The purpose of this study was to develop and test several hypotheses regarding why junior enlisted leave the Army Reserve before the end of their current obligations. Three general models were tested: demographic-pecuniary; unit activities (e.g., unit leadership, training, and administration); and family and civilian employment conflicts with Army Reserve duties in combination with unit activities. Findings support the Army Reserve continuing to offer both pecuniary incentives for joining and remaining in the Army Reserve (i.e., enlistment bonuses and educational benefits) and unit activities that promote feelings of self-worth (e.g., belonging and importance to the unit through recognition and awards) and self-development (through training in military job and general soldiers' skills). C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP PERRY, S (reprint author), WESTAT CORP,ROCKVILLE,MD, USA. NR 15 TC 12 Z9 12 U1 1 U2 3 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD FAL PY 1991 VL 18 IS 1 BP 111 EP 133 DI 10.1177/0095327X9101800106 PG 23 WC Political Science; Sociology SC Government & Law; Sociology GA HC184 UT WOS:A1991HC18400006 ER PT J AU SHUKITTHALE, B BANDERET, LE LIEBERMAN, HR AF SHUKITTHALE, B BANDERET, LE LIEBERMAN, HR TI RELATIONSHIPS BETWEEN SYMPTOMS, MOODS, PERFORMANCE, AND ACUTE MOUNTAIN-SICKNESS AT 4,700 METERS SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID ALTITUDE AB Ascents above 4,000 m adversely affect symptoms, moods, and performance and cause acute mountain sickness (AMS). It is assumed that individuals afflicted with AMS will be more susceptible to changes in these other parameters; however, previous studies have suggested that their time courses are different. This investigation analyzed the relationships between symptoms, moods, and performance and a measure of altitude sickness, the AMS-cerebral (AMS-C) factor of the Environmental Symptoms Questionnaire (ESQ). We evaluated 20 male soldiers on 11 symptom, 13 mood, and 14 cognitive/motor performance measures after exposure to altitudes of 550 and 4,700 m for 5-7 h and a difference score was calculated for each measure. The difference scores for 70% of the symptom, 46.2% of the mood, and 28.6% of the performance measures were significantly correlated with the AMS-C difference score. The difference scores for each measure were then rank ordered (to standardize for differences across measures) and the sum of the ranks was calculated for each subject's symptoms, moods, and performance. The AMS-C factor score correlated significantly 0.90, 0.77, and 0.59 with these composite measures of symptoms, moods, and performance, respectively. Changes in AMS after 5-7 h at 4,700 m were correlated best with changes in symptoms, then moods, and finally performance, suggesting that these parameters may be differentially affected at this point in time. RP SHUKITTHALE, B (reprint author), USA,ENVIRONM MED RES INST,DIV HLTH & PERFORMANCE,NATICK,MA 01760, USA. NR 26 TC 34 Z9 34 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD SEP PY 1991 VL 62 IS 9 BP 865 EP 869 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA GC826 UT WOS:A1991GC82600009 PM 1930076 ER PT J AU LATTIMORE, MR VARR, WF AF LATTIMORE, MR VARR, WF TI DISPOSABLE SOFT LENS ULCERATIVE KERATITIS IN AN ARMY AVIATOR - A CASE-REPORT SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article AB A synopsis of Army aviation interest in soft contact lenses is presented. A case report of one volunteer subject's experience with presumed contact lens-associated infectious ulcerative keratitis then is summarized. The clinical significance of this case is highlighted. C1 USA,CTR AEROMED,FT RUCKER,AL 36360. RP LATTIMORE, MR (reprint author), USA,AEROMED RES LAB,VISUAL SCI BRANCH,POB 577,FT RUCKER,AL 36362, USA. NR 7 TC 1 Z9 1 U1 0 U2 2 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD SEP PY 1991 VL 62 IS 9 BP 888 EP 889 PG 2 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA GC826 UT WOS:A1991GC82600014 PM 1930081 ER PT J AU ADAMS, CW FALL, SM PAULING, FW AF ADAMS, CW FALL, SM PAULING, FW TI PULMONARY SEQUESTRATION AS A CAUSE FOR RECURRENT PNEUMONIA SO COMPLICATIONS IN SURGERY LA English DT Article DE CONGENITAL ANOMALIES; PNEUMONIA; HEMOPTYSIS; INFECTION, PULMONARY AB Pulmonary sequestration is an uncommon congenital anomaly in which nonfunctioning lung tissue is supplied by an anomalous systemic artery. Intra- and extralobar forms exist, and develop from an accessory lung bud from the primitive foregut. Presentation may be characterized by gastrointestinal symptoms, congestive heart failure, hemoptysis, hemothorax, and, infrequently, recurrent episodes of pulmonary infections. Diagnosis is made by chest x-ray and by arteriogram. RP ADAMS, CW (reprint author), TRIPLER ARMY MED CTR,DEPT SURG,HONOLULU,HI 96859, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SCP COMMUNICATIONS INC PI NEW YORK PA 134 W 29TH ST, NEW YORK, NY 10001-5304 SN 1053-749X J9 COMPLICATION SURG JI Complicat. Surg. PD SEP PY 1991 VL 10 IS 9 BP 23 EP & PG 0 WC Surgery SC Surgery GA GD984 UT WOS:A1991GD98400004 ER PT J AU ADAMS, AH BROOKEMAN, JR MERICKEL, MB AF ADAMS, AH BROOKEMAN, JR MERICKEL, MB TI BREAST LESION DISCRIMINATION USING STATISTICAL-ANALYSIS AND SHAPE MEASURES ON MAGNETIC-RESONANCE IMAGERY SO COMPUTERIZED MEDICAL IMAGING AND GRAPHICS LA English DT Article DE BREAST DISEASE; PATTERN RECOGNITION; SEPARABILITY MEASURES; SHAPE MEASURES; TISSUE CHARACTERIZATION AB Magnetic resonance images of intact human breast tissue are evaluated using statistical measures and shape analysis. In this paper, the Mahalanobis distance measurement and a related F-statistical value demonstrate that breast lesions are statistically separable from normal breast tissue. The minimum set of parameters to provide first order statistical separability between fibroadenomas, cysts, and carcinomas are T1-weighted, T2-weighted, and Dixon opposed pulse sequences. Tumor shape is quantified by development of a compactness measure and a spatial frequency analysis of the lesion boundary. Malignant lesions are shown to be separable from benign lesions based on quantitative shape measures. RP ADAMS, AH (reprint author), USA,CTR FOREIGN SCI & TECHNOL,IMAGERY ANAL BRANCH,220 7TH ST NE,CHARLOTTESVILLE,VA 22901, USA. FU NCI NIH HHS [R0 1 CA 37072] NR 0 TC 14 Z9 14 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0895-6111 J9 COMPUT MED IMAG GRAP JI Comput. Med. Imaging Graph. PD SEP-OCT PY 1991 VL 15 IS 5 BP 339 EP 349 DI 10.1016/0895-6111(91)90142-I PG 11 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA GN013 UT WOS:A1991GN01300008 PM 1661638 ER PT J AU AKYEL, Y AF AKYEL, Y TI BEHAVIORAL SEQUELAE OF EXPOSURE TO HIGH-POWER MICROWAVE FIELDS SO CURRENT PSYCHOLOGY-RESEARCH & REVIEWS LA English DT Article AB Behavioral sequelae of exposure to high peak power microwave pulses, similar to those produced by operational radar systems and experimental, directed energy weapons systems, were studied using rats trained on fixed-ratio, variable-interval, and differential reinforcement-of-low rate schedules. Ten minute exposures to 240, 720, 2160, and 6480 pulses at a 1 Megawatt peak power level caused a rectal temperature rise of 0.7 to 2.5-degrees-C in the animals. Regardless of their schedule of reinforcement, animals exposed to the highest dose level failed to respond, on the average, for 13 minutes after the exposure when they were placed in operant conditioning chambers. However, as soon as their rectal temperatures decreased, responding resumed and no further changes in response pattern were exhibited. No long-term effects were observed in exposed animals. Thus, the behavioral effects that were seen were thermal in nature and independent of the pulsed nature of the fields. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP AKYEL, Y (reprint author), ERC BIOSERV CORP,MONTGOMERY EXECUT CTR SUITE 222,6 MONTGOMERY VILLAGE AVE,GAITHERSBURG,MD 20879, USA. NR 16 TC 0 Z9 0 U1 0 U2 0 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0737-8262 J9 CURR PSYCHOL RES REV PD FAL PY 1991 VL 10 IS 3 BP 211 EP 220 DI 10.1007/BF02686776 PG 10 WC Psychology SC Psychology GA GZ348 UT WOS:A1991GZ34800005 ER PT J AU CAPACIO, BR SHIH, TM AF CAPACIO, BR SHIH, TM TI ANTICONVULSANT ACTIONS OF ANTICHOLINERGIC DRUGS IN SOMAN POISONING SO EPILEPSIA LA English DT Article DE SOMAN; ORGANOPHOSPHORUS COMPOUNDS; CONVULSIONS; ANTICHOLINERGIC DRUGS; ANTIMUSCARINIC COMPOUNDS; ANTICONVULSANTS; SECRETIONS ID MUSCARINIC CHOLINERGIC RECEPTORS; RAT-BRAIN; -LABELED PIRENZEPINE; NERVE AGENTS; BINDING; ANTAGONISTS; ATROPINE; ACETYLCHOLINE; PROTECTION; DIAZEPAM AB The acute effects of the organophosphorus cholinesterase inhibitor soman include hypersecretions, convulsions, and death. The purpose of this study was to evaluate the anticholinergic compounds aprophen, atropine sulfate, azaprophen, benactyzine, benztropine, biperiden, scopolamine HBr, and trihexyphenidyl for their efficacy in preventing soman-induced hypersecretions and convulsions. Male rats were injected with the oxime HI-6 (125 mg/kg, i.p.), to increase survival time, along with various intramuscular doses of the anticholinergics 30 min prior to a dose of soman (180-mu-g/kg, s.c.; equivalent to 1.6 x the median lethal dose) that produced 100% convulsions. Signs of intoxication as well as the time-to-onset of convulsions were observed. The calculated anticonvulsant median effective dose values were 0.18, 0.33, 0.36, 0.55, 2.17, 2.30, 2.45, and 31.09-mu-mol/kg for scopolamine HBr, biperiden, trihexyphenidyl, benactyzine, benztropine, azaprophen, aprophen, and atropine sulfate, respectively. The same rank order of potency for inhibition of hypersecretions among these compounds was observed. Parallel studies with quaternary analogs of atropine sulfate and scopolamine HBr demonstrated, however, that these charged compounds afford no protection against soman-induced hypersecretions and convulsions. The results indicate that tertiary anticholinergic compounds afford protection against soman-induced convulsions and hypersecretions and that the beneficial anticonvulsant effects are mediated through the central cholinergic system. Excitatory amino acid neurotransmitter systems may be involved in the effectiveness of these compounds. C1 USA,CHEM DEF RES INST,DIV PHARMACOL,ATTN SGRD UV PB,ABERDEEN PROVING GROUND,MD 21010. NR 75 TC 69 Z9 69 U1 9 U2 11 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0013-9580 J9 EPILEPSIA JI Epilepsia PD SEP-OCT PY 1991 VL 32 IS 5 BP 604 EP 615 DI 10.1111/j.1528-1157.1991.tb04699.x PG 12 WC Clinical Neurology SC Neurosciences & Neurology GA GH340 UT WOS:A1991GH34000003 PM 1915166 ER PT J AU PANDOLF, KB AF PANDOLF, KB TI AGING AND HEAT TOLERANCE AT REST OR DURING WORK SO EXPERIMENTAL AGING RESEARCH LA English DT Article ID HEALTHY ELDERLY MEN; THERMOREGULATORY RESPONSES; SWEATING SENSITIVITY; PHYSICAL-FITNESS; DRY-HEAT; ACCLIMATION; EXERCISE; AGE; DEHYDRATION; WOMEN AB Collectively, the literature on heat tolerance suggests that middle-aged (45-64 year old) men and women are more work-heat intolerant, and suffer more physiological strain during heat acclimation, than do younger individuals. However, it is unclear whether the age differences in work-heat intolerance and physiological strain during heat acclimation are related to age per se or associated with other factors such as certain disease states, decreased physical activity, and/or lowered aerobic fitness. In contrast, the work-heat tolerance and physiological responses during heat acclimation of habitually active or aerobically trained middle-aged men are the same or better than younger individuals. The reviewed studies emphasize the importance of aerobic fitness and pertinent morphological factors, such as body fat, body weight, and surface area in maintaining work-heat tolerance with aging. Recent studies suggest that middle-aged and older men and women may be more susceptible to greater heat strain at physiologically significant levels of dehydration than those younger. However, additional research appears necessary to support this hypothesis. When the effects of chronic debilitating diseases in the elderly (> 64 years old) are minimized, their heat tolerance and thermoregulatory responses are comparable to those younger. In fact, healthy and well-acclimated elderly men and women appear to perform as well as those younger during desert walks in dry heat. This review shall discuss experimental observations from previously published studies concerning aging and heat tolerance or the physiological heat strain during heat acclimation at rest or during work; and, will suggest future research efforts needed to advance the area. RP PANDOLF, KB (reprint author), USA,ENVIRONM MED RES INST,NATICK,MA 01760, USA. NR 54 TC 16 Z9 16 U1 0 U2 2 PU TAYLOR & FRANCIS PI BRISTOL PA 1900 FROST ROAD, SUITE 101, BRISTOL, PA 19007-1598 SN 0361-073X J9 EXP AGING RES JI Exp. Aging Res. PD FAL PY 1991 VL 17 IS 3 BP 189 EP 204 PG 16 WC Geriatrics & Gerontology; Psychology SC Geriatrics & Gerontology; Psychology GA HL937 UT WOS:A1991HL93700005 PM 1810744 ER PT J AU YOUNG, AJ AF YOUNG, AJ TI EFFECTS OF AGING ON HUMAN COLD TOLERANCE SO EXPERIMENTAL AGING RESEARCH LA English DT Article ID TEMPERATURE REGULATION; PHYSICAL-FITNESS; WATER IMMERSION; AGE; RESPONSES; THERMOREGULATION; ENVIRONMENTS; HOMEOSTASIS; EXPOSURES; LECTURE AB The risk of hypothermia is widely considered to be greater for older than younger persons due to a reduced ability to maintain body temperature during cold exposure. Epidemiological surveys of body temperature normally maintained by older persons while in their own homes do not indicate a large incidence of hypothermia. Uncontrolled ambient conditions during body temperature measurements may have influenced those observations. Comparisons of the thermoregulatory responses to cold stress in younger and older subjects have been performed under controlled conditions in laboratory experiments. Results of these laboratory studies indicate that older men appear less able than younger men to defend their core temperature during experimental cold exposures. Cold exposure may elicit a slightly smaller rise in metabolic heat production, and the cutaneous vasoconstrictor response to cold may be slower in older than younger men. These aging effects maybe limited, however, to men. In a recent study, older women appeared to defend core temperature during cold exposure as well as, or better than younger women. The possibility that preventable changes in body composition and physical fitness, rather than aging per-se, may account for impaired thermoregulatory responses to cold has not been adequately studied. RP YOUNG, AJ (reprint author), USA,ENVIRONM MED RES INST,DIV THERMAL PHYSIOL & MED,NATICK,MA 01760, USA. NR 44 TC 24 Z9 24 U1 0 U2 2 PU TAYLOR & FRANCIS PI BRISTOL PA 1900 FROST ROAD, SUITE 101, BRISTOL, PA 19007-1598 SN 0361-073X J9 EXP AGING RES JI Exp. Aging Res. PD FAL PY 1991 VL 17 IS 3 BP 205 EP 213 PG 9 WC Geriatrics & Gerontology; Psychology SC Geriatrics & Gerontology; Psychology GA HL937 UT WOS:A1991HL93700006 PM 1810745 ER PT J AU DAUMKOWALSKI, R SHANLEY, DJ MURPHY, T AF DAUMKOWALSKI, R SHANLEY, DJ MURPHY, T TI MRI DIAGNOSIS OF DELAYED PRESENTATION OF TRAUMATIC DIAPHRAGMATIC-HERNIA SO GASTROINTESTINAL RADIOLOGY LA English DT Article DE MAGNETIC RESONANCE IMAGING; DIAPHRAGMATIC RUPTURE; DIAPHRAGMATIC HERNIA, RADIOGRAPHY; TRAUMATIC DIAPHRAGMATIC HERNIA, DELAYED ID INJURIES; RUPTURE AB Traumatic rupture of the diaphragm may go unrecognized in patients with multiple injuries to the abdomen and chest. The majority of undiagnosed diaphragmatic ruptures will eventually become symptomatic and are associated with a high mortality rate if not treated immediately. Multiplanar imaging with magnetic resonance (MR) provided a definitive diagnosis of delayed presentation of traumatic diaphragmatic hernia. RP DAUMKOWALSKI, R (reprint author), TRIPLER ARMY MED CTR,DEPT RADIOL,HONOLULU,HI 96859, USA. NR 13 TC 10 Z9 10 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0364-2356 J9 GASTROINTEST RADIOL PD FAL PY 1991 VL 16 IS 4 BP 298 EP 300 DI 10.1007/BF01887372 PG 3 WC Gastroenterology & Hepatology; Radiology, Nuclear Medicine & Medical Imaging SC Gastroenterology & Hepatology; Radiology, Nuclear Medicine & Medical Imaging GA GB782 UT WOS:A1991GB78200006 PM 1936769 ER PT J AU PARKER, LV AF PARKER, LV TI THE EFFECT OF LATEX GLOVES AND NYLON CORD ON GROUND-WATER SAMPLE QUALITY - DISCUSSION SO GROUND WATER MONITORING AND REMEDIATION LA English DT Letter RP PARKER, LV (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU GROUND WATER PUBLISHING CO PI COLUMBUS PA 2600 GROUND WATER WAY, COLUMBUS, OH 43219 SN 1069-3629 J9 GROUND WATER MONIT R JI Ground Water Monit. Remediat. PD FAL PY 1991 VL 11 IS 4 BP 167 EP 168 DI 10.1111/j.1745-6592.1991.tb00405.x PG 2 WC Water Resources SC Water Resources GA GL553 UT WOS:A1991GL55300012 ER PT J AU GIBSON, T AF GIBSON, T TI THE DIGITIZED DRUMS OF WAR SO IEEE SPECTRUM LA English DT Article RP GIBSON, T (reprint author), US MIL ACAD,COMP SCI,W POINT,NY 10996, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9235 J9 IEEE SPECTRUM JI IEEE Spectr. PD SEP PY 1991 VL 28 IS 9 BP 30 EP 30 PG 1 WC Engineering, Electrical & Electronic SC Engineering GA GD586 UT WOS:A1991GD58600009 ER PT J AU DRIELS, M KLEGKA, JS AF DRIELS, M KLEGKA, JS TI ANALYSIS OF ALTERNATIVE REWORK STRATEGIES FOR PRINTED WIRING ASSEMBLY MANUFACTURING SYSTEMS SO IEEE TRANSACTIONS ON COMPONENTS HYBRIDS AND MANUFACTURING TECHNOLOGY LA English DT Article AB This paper presents a model for predicting the cost of test, diagnosis, and rework activities in the manufacture of printed wiring assemblies (PWA's). Rework is defined as all actions taken to correct or improve the basic assembly process. These actions may include those of inspectors and solder touchup technicians who do not add value to the PWA, but whose actions are required in order to produce acceptable yields from the manufacturing process. Two alternative rework strategies for contemporary PWA manufacturing systems are presented: terminal rework and distributed rework. Rework may occur after all assembly operations have been accomplished (terminal rework) or it may be distributed throughout the assembly process. This paper analyzes the economic basis for deciding between the two rework strategies. The paper assumes that the only reason for utilizing distributed rework is to reduce the cost of producing acceptable PWA's, otherwise the cost of the distributed rework effort cannot be justified. The paper presents a model of each rework strategy. The effect of each strategy upon first pass yield (FPY) of the manufacturing process is discussed. The effect on FPY is then used to evaluate the economic benefit of each rework strategy as an aid in deciding which strategy to use. The increase in FPY needed to justify distributed rework is calculated. C1 US MIL ACAD,DEPT CIVIL & MECH ENGN,W POINT,NY 10996. RP DRIELS, M (reprint author), USN,POSTGRAD SCH,DEPT MECH ENGN,MONTEREY,CA 93943, USA. NR 17 TC 8 Z9 8 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0148-6411 J9 IEEE T COMPON HYBR PD SEP PY 1991 VL 14 IS 3 BP 637 EP 644 DI 10.1109/33.83956 PG 8 WC Engineering, Manufacturing; Engineering, Electrical & Electronic; Materials Science, Multidisciplinary SC Engineering; Materials Science GA GC910 UT WOS:A1991GC91000032 ER PT J AU ARCONE, SA AF ARCONE, SA TI DIELECTRIC-CONSTANT AND LAYER-THICKNESS INTERPRETATION OF HELICOPTER-BORNE SHORT-PULSE RADAR WAVE-FORMS REFLECTED FROM WET AND DRY RIVER-ICE SHEETS SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article AB Analysis of short-pulse radar data taken over river ice sheets in late spring reveals that radar signal penetration of an ice sheet and determination of its thickness are not necessarily prevented by the presence of surface water or internal melting. Radar data for both wet and dry ice were extracted from surveys performed from a helicopter operating at an altitude of about 2-7 m and a speed of about 5 m/s over the Connecticut River near Windsor, Vermont. The radar used a broadband wavelet of several nanoseconds duration at a center frequency of about 500 MHz. By use of plane wave theory, the dielectric constant of ice is interpreted from the amplitudes of reflections from a solid ice sheet. This verification of plane-wave interpretation and the lack of dispersion seen in wet ice bottom returns are then used to interpret data from segments of a wet ice sheet survey for both ice thickness and surface water depth. Other ice sheet segments, for which the data allow only sporadic interpretation of ice depth, are interpreted as having internal melting. It is concluded that ice thickness can be determined for surface water layers less than about 8-mm thick for the particular wavelet used so long as the ice interfaces are not severely rough. RP ARCONE, SA (reprint author), CORPS ENGINEERS,COLD REG RES & ENGN LAB,HANOVER,NH 03355, USA. NR 19 TC 19 Z9 20 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD SEP PY 1991 VL 29 IS 5 BP 768 EP 777 DI 10.1109/36.83992 PG 10 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA GD090 UT WOS:A1991GD09000010 ER PT J AU KRISHNAKUMAR, KS SAWAL, D BAILEY, JE DOHME, JA AF KRISHNAKUMAR, KS SAWAL, D BAILEY, JE DOHME, JA TI A SIMULATOR-BASED AUTOMATED HELICOPTER HOVER TRAINER-SYNTHESIS AND VERIFICATION SO IEEE TRANSACTIONS ON SYSTEMS MAN AND CYBERNETICS LA English DT Article AB An approach to the application of flight simulators for automated training of novice student pilots, with limited human interaction, is presented. A hypothesis for automated human training is presented; and based on this hypothesis, a synthesis procedure for a simulator-based automated hover trainer is developed. The synthesis uses the theory of optimal control pilot modeling for designing varying levels of stability augmentation, which mimics certain aspects of an instructor pilot. Simulator implementation of the hover trainer utilizes an adaptive loop to provide continuous augmentation level changes based on the students' learning curve. Experimental verification of the hypothesis, using a group of neophytes, showed that neophytes could be successfully trained using the automated hover trainer. C1 UNIV MICHIGAN,DEPT AEROSP ENGN,ANN ARBOR,MI 48109. USA,RES INST,FT RUCKER,AL 36360. RP KRISHNAKUMAR, KS (reprint author), UNIV ALABAMA,DEPT AEROSP ENGN,TUSCALOOSA,AL 35487, USA. NR 10 TC 2 Z9 2 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9472 J9 IEEE T SYST MAN CYB JI IEEE Trans. Syst. Man Cybern. PD SEP-OCT PY 1991 VL 21 IS 5 BP 961 EP 970 DI 10.1109/21.120049 PG 10 WC Computer Science, Cybernetics; Engineering, Electrical & Electronic SC Computer Science; Engineering GA HG003 UT WOS:A1991HG00300003 ER PT J AU GUALTIERI, JG KOSINSKI, JA AF GUALTIERI, JG KOSINSKI, JA TI ELECTRODE-INDUCED NONUNIFORMITIES IN THE SWEEPING OF ALPHA-QUARTZ SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Article ID STABILITY; YBA2CU3O7; FILMS AB Electrode metal-quartz contact, metal porosity, and metal/quartz interfacial diffusion of hydrogen-species are required for efficient and uniform hydrogen introduction during air-sweeping. Nonuniform hydrogen introduction can be indicated by the cointroduction of either electrode-metal or color centers. Color-center introduction during air sweeping leads to nonuniform sweeping along the Z-axis similar to the nonuniform sweeping found with vacuum sweeping. Using infrared absorption and scanning electron microscopic techniques, it has been found that color-center and/or electrode-metal introduction into quartz is influenced by the porosity of evaporated metal electrodes. It appears that thermal-stress relief of electrode-metal films, during sweeping, normally causes void formation (porosity). If the porosity is extensive, H introduction predominates and color-center and electrode-metal introduction mechanisms are suppresed. Samples swept with evaporated Au-Cr electrodes relying on thermal stress-induced porosity sometimes displayed these sweeping nonuniformities. However, nonuniformities were not found when samples were swept using evaporated Au-Cr electrodes containing periodic stripe openings. Electrodes with stripe openings were fabricated using photolithographic techniques. The stripe openings provided sufficient electrode-quartz-water vapor (three-phase) regions to ensure uniform sweeping. Uniform sweeping was also obtained using magnetron-sputtered amorphous Y-Ba-Cu-O films. These electrically conducting oxide films apparently allow indiffusion of hydrogen without the need of porosity or electrode openings to assist in the H indiffusion sweeping process. RP GUALTIERI, JG (reprint author), USA,ETDL,SLCET MA A,FT MONMOUTH,NJ 07703, USA. NR 33 TC 3 Z9 3 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD SEP PY 1991 VL 38 IS 5 BP 486 EP 493 DI 10.1109/58.84294 PG 8 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA GD024 UT WOS:A1991GD02400012 PM 18267611 ER PT J AU GUALTIERI, JG BLISNUK, KL AF GUALTIERI, JG BLISNUK, KL TI SPURIOUS SURFACE FINISH IMPROVEMENT OF THE INFRARED EXTINCTION COEFFICIENT OF ALPHA-QUARTZ SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Article AB Infrared extinction coefficients obtained using quartz samples lapped with a 3-mu-m abrasive compound were found to be much smaller than anticipated. The "improvement" in the extinction coefficient is traceable to the irregular surface finish. To demonstrate this "improvement," polished quartz samples were evaluated and compared to evaluations after lapping the same sample with 3-mu-m and 12-mu-m abrasives. In one sample, a 3-mu-m finish resulted in an almost 30% "improvement" in the extinction coefficient evaluated at 3500 cm-1. Further lapping of the sample to a 12-mu-m finish resulted in an almost 90% "improvement." These "improvements" in alpha-correspond to "improvements" in Q(IR) (3500) from 2.58 million (polished) to 3.03 million (3-mu-m) to 4.71 million (12-mu-m). It is shown that the "improvement" is caused by wavelength dependent transmission losses due to surface irregularities. The surface transmission losses can be reduced by either polishing the optical surfaces or by applying index matching fluids to 3-mu-M lapped surfaces. This spurious improvement underscores the importance of a requirement in the Standards to polish or index match surfaces of test samples used in infrared grading of cultured quartz. RP GUALTIERI, JG (reprint author), USA,ETDL,SLCET MA A,FT MONMOUTH,NJ 07703, USA. NR 8 TC 0 Z9 0 U1 1 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD SEP PY 1991 VL 38 IS 5 BP 494 EP 497 DI 10.1109/58.84295 PG 4 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA GD024 UT WOS:A1991GD02400013 PM 18267612 ER PT J AU ELKINS, KL BULLER, RML STASHAK, PW BAKER, PJ AF ELKINS, KL BULLER, RML STASHAK, PW BAKER, PJ TI CD4+ T-CELLS REGULATE THE MAGNITUDE OF THE ANTIBODY-RESPONSE TO SEVERAL HELPER T-CELL INDEPENDENT ANTIGENS SO IMMUNOBIOLOGY LA English DT Article ID BACTERIAL POLYSACCHARIDE ANTIGENS; B-CELLS; MONOCLONAL-ANTIBODY; LYMPHOCYTE-T; IMMUNOLOGICAL-UNRESPONSIVENESS; INVIVO; L3T4; LIPOPOLYSACCHARIDES; SUBPOPULATIONS; MODULATION AB The effect of prior depletion of CD4+ T cells on the magnitude of the primary antibody response to several antigens considered to be helper T cell independent (TI) was examined. Treatment of mice with the monoclonal antibody GK1.5 to remove CD4+ T cells had little effect on the magnitude of the specific antibody response to the lipopolysaccharide (LPS) of Escherichia coli 0113; however, such treatment reduced the magnitude of the splenic IgM antibody response to E. coli 055 LPS, Serratia marcescens LPS, TNP-Ficoll, and Type III pneumococcal polysaccharide (SSS-III), compared to control untreated or rat IgG treated mice. Thus, CD4+ T cells positively influence of magnitude of the antibody response to the majority of helper T cell independent antigens tested. C1 NIAID,IMMUNOGENET,TWINBROOK 2 RES FACIL,ROCKVILLE,MD. NIAID,VIRAL DIS LAB,BETHESDA,MD 20892. RP ELKINS, KL (reprint author), WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,9260 MED CTR DR,ROCKVILLE,MD 20910, USA. NR 31 TC 3 Z9 3 U1 0 U2 0 PU GUSTAV FISCHER VERLAG PI STUTTGART PA WOLLGRASWEG 49, D-70599 STUTTGART, GERMANY SN 0171-2985 J9 IMMUNOBIOLOGY JI Immunobiology PD SEP PY 1991 VL 183 IS 1-2 BP 69 EP 78 PG 10 WC Immunology SC Immunology GA GF865 UT WOS:A1991GF86500006 PM 1682242 ER PT J AU BAKER, NR MINOR, V DEAL, C SHAHRABADI, MS SIMPSON, DA WOODS, DE AF BAKER, NR MINOR, V DEAL, C SHAHRABADI, MS SIMPSON, DA WOODS, DE TI PSEUDOMONAS-AERUGINOSA EXOENZYME-S IS AN ADHESIN SO INFECTION AND IMMUNITY LA English DT Article ID CYSTIC-FIBROSIS PATIENTS; BUCCAL EPITHELIAL-CELLS; SIALIC-ACID; PILI; IDENTIFICATION; ADHERENCE; PROTEINS; RECEPTORS AB Exoenzyme S from Pseudomonas aeruginosa has been studied as an adhesin for glycosphingolipids and buccal cells. Binding of exoenzyme S to gangliotriosylceramide (GalNAc-beta-1-4Gal-beta-1-4Glc-beta-1-1Cer), gangliotetraosylceramide (Gal-beta-1-3GalNAcT-beta-1-4Gal-beta-1-4Glc-beta-1-1Cer), and lactosylceramide (Gal-beta-1-4Glc-beta-1-1Cer) separated on thin-layer chromatograms was observed. Binding curves for exoenzyme S with dilutions of gangliotetraosylceramide immobilized on plastic plates were similar to previously reported results for the intact bacteria. Binding of exoenzyme S to sialylated counterparts of these glycosphingolipids was not seen, indicating that the addition of a sialic acid residue interferes with binding. Exoenzyme S and monoclonal antibody to exoenzyme S inhibit the binding of P. aeruginosa to buccal cells. The presence of exoenzyme S on the surface of P. aeruginosa was detected by immunogold labeling of bacteria with antibodies to exoenzyme S. Results of these studies led us to conclude that exoenzyme S is an important adhesin of P. aeruginosa. C1 OHIO STATE UNIV,DEPT MICROBIOL,COLUMBUS,OH 43210. WALTER REED ARMY MED CTR,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. UNIV CALGARY,HLTH SCI CTR,DEPT MICROBIOL & INFECT DIS,CALGARY T2N 4N1,ALBERTA,CANADA. NR 30 TC 67 Z9 68 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD SEP PY 1991 VL 59 IS 9 BP 2859 EP 2863 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA GD020 UT WOS:A1991GD02000001 PM 1679039 ER PT J AU FORTIER, AH SLAYTER, MV ZIEMBA, R MELTZER, MS NACY, CA AF FORTIER, AH SLAYTER, MV ZIEMBA, R MELTZER, MS NACY, CA TI LIVE VACCINE STRAIN OF FRANCISELLA-TULARENSIS - INFECTION AND IMMUNITY IN MICE SO INFECTION AND IMMUNITY LA English DT Article ID T-CELL RECEPTOR; GAMMA-DELTA; MYCOBACTERIUM-TUBERCULOSIS; LYMPHOCYTES; TULAREMIA; MODEL AB The live vaccine strain (LVS) of Francisella tularensis caused lethal disease in several mouse strains. Lethality depended upon the dose and route of inoculation. The lethal dose for 50% of the mice (LD50) in four of six mouse strains (A/J, BALB/cHSD, C3H/HeNHSD, and SWR/J) given an intraperitoneal (i.p.) inoculation was less than 10 CFU. For the other two strains tested, C3H/HeJ and C57BL/6J, the i.p. log LD50 was 1.5 and 2.7, respectively. Similar susceptibility was observed in mice inoculated by intravenous (i.v.) and intranasal (i.n.) routes: in all cases the LD50 was less than 1,000 CFU. Regardless of the inoculation route (i.p., i.v., or i.n.), bacteria were isolated from spleen, liver, and lungs within 3 days of introduction of bacteria; numbers of bacteria increased in these infected organs over 5 days. In contrast to the other routes of inoculation, mice injected with LVS intradermally (i.d.) survived infection: the LD50 of LVS by this route was much greater than 10(5) CFU. This difference in susceptibility was not due solely to local effects at the dermal site of inoculation, since bacteria were isolated from the spleen, liver, and lungs within 3 days by this route as well. The i.d.-infected mice were immune to an otherwise lethal i.p. challenge with as many as 10(4) CFU, and immunity could be transferred with either serum, whole spleen cells, or nonadherent spleen cells (but not Ig+ cells). A variety of infectious agents induce different disease syndromes depending on the route of entry. Francisella LVS infection in mice provides a model system for analysis of locally induced protective effector mechanisms. C1 WALTER REED ARMY MED CTR,DEPT COMPARAT PATHOL,WASHINGTON,DC 20307. RP FORTIER, AH (reprint author), WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,WASHINGTON,DC 20307, USA. NR 23 TC 206 Z9 209 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD SEP PY 1991 VL 59 IS 9 BP 2922 EP 2928 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA GD020 UT WOS:A1991GD02000010 PM 1879918 ER PT J AU MCCAUL, TF BANERJEEBHATNAGAR, N WILLIAMS, JC AF MCCAUL, TF BANERJEEBHATNAGAR, N WILLIAMS, JC TI ANTIGENIC DIFFERENCES BETWEEN COXIELLA-BURNETII CELLS REVEALED BY POSTEMBEDDING IMMUNOELECTRON MICROSCOPY AND IMMUNOBLOTTING SO INFECTION AND IMMUNITY LA English DT Article ID Q-FEVER ENDOCARDITIS; POLYACRYLAMIDE GELS; IMMUNOLOGICAL PROPERTIES; MONOCLONAL-ANTIBODIES; ESCHERICHIA-COLI; PHASE VARIANTS; PROTEINS; LIPOPOLYSACCHARIDES; NITROCELLULOSE; TRYPANOSOMES AB The aim of this study was to investigate the antigenic structures of the morphologically distinct cells of the Coxiella burnetii developmental cycle. Postembedding immunoelectron microscopy with polyclonal antibodies produced in rabbits to (i) phase I cells, (ii) a chloroform-methanol residue fraction of cells, (iii) the cell walls (CW) of large and small cells and small dense cells (SDC), and (iv) the peptidoglycan-protein complexes of small cells and SDC labelled the continuum of morphologically distinct cells. But these antibodies did not distinguish between the antigenic structures of the various cells. Monoclonal antibodies to the phase I lipopolysaccharide labelled the CW of a majority of the smaller cells, but there was diminished reactivity to the larger cells. Although monoclonal antibodies to a 29.5-kDa outer membrane protein labelled the CW of the large mother cells, the large cells, and the small cells, a minority of the SDC with compact CW were not labelled. The endogenous spore within the mother cell was not labelled by the polyclonal or monoclonal antibodies to cellular components. A selected population of SDC was prepared by osmotic lysis of large cells, differential centrifugation, Renografin step-gradient fractionation, and breakage of the small cells in a French press at 20,000 lb/in2. The pressure-resistant SDC collected as fraction CL did not contain the 29.5-kDa protein, as evidenced by the lack of (i) Coomassie brilliant blue staining of protein in the 29.5-kDa region of sodium dodecyl sulfate-polyacrylamide gels and (ii) reactivity of the 29.5-kDa protein antigenic epitopes in immunoblotting with monoclonal antibodies to the protein. In contrast, CW of the pressure-sensitive small cells contained the 29.5-kDa protein. Therefore, the observed ultrastructural differences between large and small cells and SDC reflect differences in sensitivity to breakage by pressure treatment and in cell-associated antigens. Although the process of differentiation in C. burnetii remains an enigma, we have taken steps toward identifying cellular antigens as markers of differentiation. The pressure-resistant SDC in fraction CL that are devoid of the 29.5-kDa protein may be useful for answering questions about the physiological events required for triggering outgrowth and sequential regulation of the Coxiella developmental cycle. C1 USA,MED RES INST INFECT DIS,DEPT INTRACELLULAR PATHOGENS,DIV BACTERIOL,FT DETRICK,FREDERICK,MD 21702. NIAID,OFF DIRECTOR INTRAMURAL RES PROGRAMS,BETHESDA,MD 20892. NR 39 TC 35 Z9 35 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD SEP PY 1991 VL 59 IS 9 BP 3243 EP 3253 PG 11 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA GD020 UT WOS:A1991GD02000055 PM 1715326 ER PT J AU LETTERIE, GS RAMIREZ, EJ AF LETTERIE, GS RAMIREZ, EJ TI SERUM HUMAN CHORIONIC-GONADOTROPIN - SURVEILLANCE AFTER RADICAL AND CONSERVATIVE MANAGEMENT OF ECTOPIC PREGNANCY SO INTERNATIONAL JOURNAL OF FERTILITY LA English DT Article ID GONADOTROPIN AB Monitoring of serum hCG concentrations has become an integral part of the postoperative management of patients with ectopic pregnancy. We monitored serial serum hCG concentrations in 25 patients to determine and compare the time for eventual clearance for two groups of patients managed by either radical or conservative surgery. Fifteen patients with ruptured ectopic pregnancy were managed by salpingectomy (group A) and 10 patients with unruptured ectopic pregnancy were managed by salpingostomy (group B). Serum samples were drawn on the first postoperative day (day 0) and at three-day intervals thereafter and followed to the limits of detectability. Serum hCG levels on day 0 were 3,542 +/- 480 mIU/mL (mean +/- standard deviation [SD]) with a range of 117 to 10,300 mIU/mL for group A, and 1,022 +/- 282 mIU/mL (mean +/- SD) with a range of 17 to 4,180 mIU/mL for group B. Time required for clearance to <10 mIU/mL was 14 +/- 4.9 days with a range of 2 to 28 days for group A and 12 +/- 3.9 days with a range of 2 to 16 days for group B. The primary factor influencing clearance was initial hCG concentration. Based on clearance data, a nomogram was developed to assist in the postoperative management and timing of serum sampling for hCG. RP LETTERIE, GS (reprint author), TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,REPROD ENDOCRINOL SERV,HONOLULU,HI 96859, USA. NR 5 TC 3 Z9 3 U1 0 U2 0 PU MEDICAL SCIENCE PUBLISHING INT INC PI PORT WASHINGTON PA 405 MAIN ST, PORT WASHINGTON, NY 11050 SN 0020-725X J9 INT J FERTIL PD SEP-OCT PY 1991 VL 36 IS 5 BP 268 EP & PG 0 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA GJ749 UT WOS:A1991GJ74900001 PM 1683654 ER PT J AU WADHAMS, P DAVIS, NR COMISO, JC KUTZ, R CRAWFORD, J JACKSON, G KRABILL, W SEAR, CB SWIFT, R TUCKER, WB AF WADHAMS, P DAVIS, NR COMISO, JC KUTZ, R CRAWFORD, J JACKSON, G KRABILL, W SEAR, CB SWIFT, R TUCKER, WB TI CONCURRENT REMOTE-SENSING OF ARCTIC SEA ICE FROM SUBMARINE AND AIRCRAFT SO INTERNATIONAL JOURNAL OF REMOTE SENSING LA English DT Article AB In May 1987 a concurrent remote sensing study of Arctic sea ice from above and below was carried out. A submarine equipped with sidescan and upward looking sonar collaborated with two remote sensing aircraft equipped with passive microwave, synthetic aperture radar (SAR), a laser profilometer and an infrared radiometer. By careful registration of the three tracks it has been possible to find relationships between ice type, ice morphology and thickness, SAR backscatter and microwave brightness temperatures. The key to the process has been the sidescan sonar's ability to identify ice type through differences in characteristic topography. Over a heavily ridged area of mainly multiyear ice there is a strong positive correlation between SAR backscatter and ice draft or elevation. We also found that passive and active microwave complement each other in that SAR has a high contrast between open water and multiyear ice, while passive microwave has a high contrast between open water and first-year ice. C1 NASA,GODDARD SPACE FLIGHT CTR,GODDARD SPACE FLIGHT LAB,OCEAN LAB,GREENBELT,MD 20771. CALTECH,JET PROP LAB,PASADENA,CA 91109. ADMIRALTY RES ESTAB,PORTLAND,DORSET,ENGLAND. NASA,WALLOPS FLIGHT FACIL,WALLOPS ISL,VA 23337. SCI APPLICAT INT CORP,WESTBROOK CTR,CAMBRIDGE CB4 1YQ,ENGLAND. EGEG WASHINGTON ANALYT SERV CTR,POCOMOKE CITY,MD 21851. USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. RP WADHAMS, P (reprint author), UNIV CAMBRIDGE,SCOTT POLAR RES INST,CAMBRIDGE CB2 1ER,ENGLAND. NR 8 TC 17 Z9 17 U1 1 U2 7 PU TAYLOR & FRANCIS LTD PI LONDON PA ONE GUNDPOWDER SQUARE, LONDON, ENGLAND EC4A 3DE SN 0143-1161 J9 INT J REMOTE SENS JI Int. J. Remote Sens. PD SEP PY 1991 VL 12 IS 9 BP 1829 EP 1840 PG 12 WC Remote Sensing; Imaging Science & Photographic Technology SC Remote Sensing; Imaging Science & Photographic Technology GA GE543 UT WOS:A1991GE54300004 ER PT J AU RAINES, EF AF RAINES, EF TI THE GOOD YEAR, MACARTHUR AND SUTHERLAND - ROGERS,PP SO JOURNAL OF AMERICAN HISTORY LA English DT Book Review RP RAINES, EF (reprint author), USA,CTR MIL HIST,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ORGAN AMER HISTORIANS PI BLOOMINGTON PA 112 N BRYAN ST, BLOOMINGTON, IN 47401 SN 0021-8723 J9 J AM HIST JI J. Am. Hist. PD SEP PY 1991 VL 78 IS 2 BP 730 EP 731 DI 10.2307/2079663 PG 2 WC History SC History GA GF124 UT WOS:A1991GF12400136 ER PT J AU SEGLETES, SB AF SEGLETES, SB TI THERMODYNAMIC STABILITY OF THE MIE-GRUNEISEN EQUATION OF STATE, AND ITS RELEVANCE TO HYDROCODE COMPUTATIONS SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID RATES AB The role of the equation of state (EOS) is reviewed as an analytical vehicle to express material pressure as a function of density and temperature (or internal energy in the case of adiabatic transition). Starting from the fundamental laws of thermodynamics, three criteria are developed to measure the stability of equations of state, and are applied specifically to the Mie-Gruneisen EOS, with Hugoniot reference, to investigate the stability characteristics thereof. This EOS is singled out for study because of its relative importance in the computational modeling of shock transition. Results indicate numerous possibilities of instability under various circumstances. Various remedies are proposed to correct the observed instabilities and compared with existing models. RP SEGLETES, SB (reprint author), USA,BALLIST RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 22 TC 17 Z9 18 U1 0 U2 3 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD SEP 1 PY 1991 VL 70 IS 5 BP 2489 EP 2499 DI 10.1063/1.349406 PG 11 WC Physics, Applied SC Physics GA GE658 UT WOS:A1991GE65800001 ER PT J AU LAUVER, D CHANG, A AF LAUVER, D CHANG, A TI TESTING THEORETICAL EXPLANATIONS OF INTENTION TO SEEK CARE FOR A BREAST-CANCER SYMPTOM SO JOURNAL OF APPLIED SOCIAL PSYCHOLOGY LA English DT Article ID SELF-EXAMINATION; REASONED ACTION; PATIENT DELAY; FOLLOW-UP; BEHAVIOR; DETERMINANTS; MAMMOGRAPHY; SURVIVAL; WOMEN; SUSCEPTIBILITY C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. RP LAUVER, D (reprint author), UNIV WISCONSIN,SCH NURSING,CSC K6-262,MADISON,WI 53792, USA. NR 56 TC 22 Z9 22 U1 0 U2 0 PU V H WINSTON & SON INC PI PALM BEACH PA 360 SOUTH OCEAN BLVD, PH-B, PALM BEACH, FL 33480 SN 0021-9029 J9 J APPL SOC PSYCHOL JI J. Appl. Soc. Psychol. PD SEP 1 PY 1991 VL 21 IS 17 BP 1440 EP 1458 DI 10.1111/j.1559-1816.1991.tb00480.x PG 19 WC Psychology, Social SC Psychology GA GH866 UT WOS:A1991GH86600004 ER PT J AU ROBINSON, NA MATSON, CF PACE, JG AF ROBINSON, NA MATSON, CF PACE, JG TI ASSOCIATION OF MICROCYSTIN-LR AND ITS BIOTRANSFORMATION PRODUCT WITH A HEPATIC-CYTOSOLIC PROTEIN SO JOURNAL OF BIOCHEMICAL TOXICOLOGY LA English DT Article DE MICROCYSTIN; MICROCYSTIS-AERUGINOSA; PROTEIN PHOSPHATASES; OKADAIC ACID; PROTEIN BINDING; BIOTRANSFORMATION; METABOLISM; INVITRO ACTIVITY ID ISOLATED RAT HEPATOCYTES; CYCLIC PEPTIDE TOXIN; MAMMALIAN-TISSUES; AERUGINOSA; PHOSPHATASES; HEPATOTOXIN; INVITRO; INVIVO; MICE; NODULARIN AB Microcystin-LR (MCYST-LR), a cyclic peptide hepatotoxin, associates with high-molecular-weight, liver cytosolic components. Repetitive cycles of heat denaturation and pronase digestion released 80 +/- 6% of the bound radiolabel from these components, parent toxin (22%), and two biotransformation products, with high-performance liquid chromatography (HPLC) retention times of 6.7 (52%) and 5.6 (13%) min. Both parent and the biotransformed (6.7 min) toxin appeared to be covalently bound to a monomeric protein of molecular weight 40,000 (protein plus radiolabeled toxin). Binding and biotransformation reactions were time- and temperature-dependent and did not require endogenous molecules < 6,000 daltons. The binding appeared to be saturable with a maximum of 20 pmol MCYST-LR bound per mg protein. The binding protein(s) and biotransformation activity were present in rat liver, brain, kidney, heart, lung, small intestine, large intestine, testes, skeletal muscle, and to a lesser extent, in fat. Okadaic acid, a specific protein phosphatase inhibitor, showed a concentration-dependent inhibition of [H-3]MCYST-LR binding to hepatic cytosol. The molecular weight and organ distribution of the binding protein(s), and inhibition of binding by okadaic acid were consistent with one of the binding sites being the catalytic subunit of protein phosphatase type 2A. C1 USA,MED RES INST INFECT DIS,DIV PATHOPHYSIOL,FT DETRICK,FREDERICK,MD 21702. NR 35 TC 24 Z9 25 U1 0 U2 4 PU VCH PUBLISHERS INC PI DEERFIELD BEACH PA 303 NW 12TH AVE, DEERFIELD BEACH, FL 33442-1788 SN 0887-2082 J9 J BIOCHEM TOXICOL JI J. Biochem. Toxicol. PD FAL PY 1991 VL 6 IS 3 BP 171 EP 180 DI 10.1002/jbt.2570060303 PG 10 WC Toxicology SC Toxicology GA GJ334 UT WOS:A1991GJ33400002 PM 1770501 ER PT J AU FORCH, BE MERROW, CN AF FORCH, BE MERROW, CN TI PHOTODISSOCIATION PROCESSES IN CARBON-MONOXIDE AT 193 NM SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID INTRAMOLECULAR VIBRATIONAL REDISTRIBUTION; 3-PHOTON IONIZATION; STATE DISTRIBUTION; LASER IONIZATION; TRIPLET-STATES; CROSS-SECTIONS; ATOMIC OXYGEN; CO MOLECULE; ARF LASER; DISSOCIATION AB The photodissociation of carbon monoxide at 193 nm has been investigated using resonance enhanced multiphoton ionization detection of atomic oxygen and carbon fragments. The results of these experiments indicate a quadratic photodissociation process in CO at 12.8 eV. In addition, the nascent fine structure branching ratios of atomic oxygen 2p4 (3P2,1,0) produced in the 193 nm photodissociation of CO are reported using both multiphoton laser induced fluorescence and ionization detection. Analysis of the experimental data and computer generated simulations indicate that the distributions are not statistical. C1 USA,CTR CHEM RES DEV & ENGN,SMCCR,DDT,ABERDEEN PROVING GROUND,MD 21005. RP FORCH, BE (reprint author), USA,SLCBR,IBI,BALLIST RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 28 TC 11 Z9 11 U1 2 U2 4 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD SEP 1 PY 1991 VL 95 IS 5 BP 3252 EP 3257 DI 10.1063/1.460882 PG 6 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA GD055 UT WOS:A1991GD05500026 ER PT J AU DELEON, PH FOLEN, RA JENNINGS, FL WILLIS, DJ WRIGHT, RH AF DELEON, PH FOLEN, RA JENNINGS, FL WILLIS, DJ WRIGHT, RH TI THE CASE FOR PRESCRIPTION PRIVILEGES - A LOGICAL EVOLUTION OF PROFESSIONAL PRACTICE SO JOURNAL OF CLINICAL CHILD PSYCHOLOGY LA English DT Article ID PSYCHOLOGY; CHILDREN; POLICY C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. UNIV OKLAHOMA,HLTH SCI CTR,OKLAHOMA CITY,OK 73190. RP DELEON, PH (reprint author), US SENATE STAFF,722 HART SENATE BLDG,WASHINGTON,DC 20510, USA. NR 92 TC 29 Z9 29 U1 1 U2 1 PU LAWRENCE ERLBAUM ASSOC INC PI MAHWAH PA 10 INDUSTRIAL AVE, MAHWAH, NJ 07430-2262 SN 0047-228X J9 J CLIN CHILD PSYCHOL JI J. Clin. Child Psychol. PD SEP PY 1991 VL 20 IS 3 BP 254 EP 267 DI 10.1207/s15374424jccp2003_4 PG 14 WC Psychology, Clinical; Psychology, Developmental SC Psychology GA GH435 UT WOS:A1991GH43500004 ER PT J AU OPAL, SM CROSS, AS SADOFF, JC COLLINS, HH KELLY, NM VICTOR, GH PALARDY, JE BODMER, MW AF OPAL, SM CROSS, AS SADOFF, JC COLLINS, HH KELLY, NM VICTOR, GH PALARDY, JE BODMER, MW TI EFFICACY OF ANTILIPOPOLYSACCHARIDE AND ANTITUMOR NECROSIS FACTOR MONOCLONAL-ANTIBODIES IN A NEUTROPENIC RAT MODEL OF PSEUDOMONAS SEPSIS SO JOURNAL OF CLINICAL INVESTIGATION LA English DT Article DE ENDOTOXIN; SEPTIC SHOCK; PSEUDOMONAS-AERUGINOSA; CYTOKINES; IMMUNOTHERAPY ID GRAM-NEGATIVE BACTEREMIA; ESCHERICHIA-COLI; PROTECTS MICE; SEPTIC SHOCK; LETHAL INFECTION; ENDOTOXIN CORE; FACTOR-ALPHA; CACHECTIN; INTERLEUKIN-1; AERUGINOSA AB Monoclonal antibodies (MAb) directed against bacterial lipopolysaccharide (LPS) and tumor necrosis factor-alpha (TNF) provide partial protection in experimental models of septic shock. To determine if additional benefit accrues from a combination of anti-TNF and anti-LPS MAb in the treatment of septic shock, a neutropenic rat model was developed to study active infection with Pseudomonas aeruginosa 12.4.4. Animals were treated intravenously with an irrelevant MAb (group 1); anti-TNF MAb (group 2); MAb directed against P. aeruginosa 12.4.4 LPS (group 3); or a combination of anti-TNF and anti-LPS MAb (group 4). None of the control animals in group 1 survived the 7-d period of neutropenia (0/16). In contrast, the survival rate was 44% in group 2 (P < 0.02); 37% in group 3 (P < 0.05); and 75% in group 4 (P < 0.0002). The combination of monoclonal antibodies provided greater protection than either MAb given alone (P < 0.05). Serum TNF levels during infection were significantly greater in groups 1 and 3 (20.1 +/- 3.3 U, mean +/- SE) than in groups 2 and 4 (0.9 +/- 0.8 U, P < 0.0001). These results indicate that a combination of monoclonal antibodies to LPS and TNF have additive benefit in experimental Pseudomonas aeruginosa sepsis. This immunotherapeutic approach may be of potential utility in the management of serious, gram-negative bacterial infection in neutropenic patients. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. CELLTECH LTD,SLOUGH SL1 4EN,ENGLAND. BROWN UNIV,PROGRAM MED,PROVIDENCE,RI 02912. RP OPAL, SM (reprint author), MEM HOSP RHODE ISL,DIV INFECT DIS,PROVIDENCE,RI 02912, USA. NR 32 TC 59 Z9 59 U1 0 U2 0 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 222 E 70TH STREET, NEW YORK, NY 10021 SN 0021-9738 J9 J CLIN INVEST JI J. Clin. Invest. PD SEP PY 1991 VL 88 IS 3 BP 885 EP 890 DI 10.1172/JCI115390 PG 6 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA GD669 UT WOS:A1991GD66900022 PM 1885775 ER PT J AU HUBERTZ, JM DRIVER, DB REINHARD, RD AF HUBERTZ, JM DRIVER, DB REINHARD, RD TI WIND-WAVES ON THE GREAT-LAKES - A 32 YEAR HINDCAST SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE GREAT LAKES; WAVES; HINDCAST; WAVE INFORMATION STUDY; WAVE SPECTRA AB Information on winds and waves near the coast is critical to scientists and engineers working on a variety of problems on the Great Lakes. These include design of coastal structures, estimation of erosion rates, and aspects of navigational and recreational safety. Very few measurements of winds and waves are available along the coastlines of the lakes and none are of long duration. The Wave Information Study (WIS) at the Coastal Engineering Research Center (CERC) has addressed this lack of information by completing a 32-year hindcast of wind and wave conditions at locations 10 miles apart along the shorelines of the Great Lakes. Results are summarized in reports for each lake. Wind speed and direction are available every 3 hours for the 32-year period from 1956-1987 over a 10 mile grid on each lake. Directional wave spectra also are available each 3 hours for the 32 years at each location near shore and other selected points over the lakes. The procedures used to produce this information are discussed and examples of verification against measurements are shown. RP HUBERTZ, JM (reprint author), USAE WATERWAYS EXPT STN,COASTAL ENGN RES CTR,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 0 TC 10 Z9 10 U1 0 U2 2 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD FAL PY 1991 VL 7 IS 4 BP 945 EP 967 PG 23 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA GF130 UT WOS:A1991GF13000001 ER PT J AU CAMPBELL, CBG HODOS, W AF CAMPBELL, CBG HODOS, W TI THE SCALA-NATURAE REVISITED - EVOLUTIONARY SCALES AND ANAGENESIS IN COMPARATIVE PSYCHOLOGY SO JOURNAL OF COMPARATIVE PSYCHOLOGY LA English DT Article AB Recent suggestions that evolutionary scales have a place in theorization about the evolution of behavior have been based on the concept of anagenesis, formerly associated with notions of biological progress. An associated concept is that of grades, often used as units of anagenetic advance. Advocates of anagenetic analysis in comparative psychology cite the writings of biologists Bernard Rensch, Julian Huxley, George Gaylord Simpson, and Stephen Jay Gould to support the usefulness of anagenesis but treat the positions of each of these theorists as if they were the same. In fact, they differ considerably in their definition of anagenesis and in its application to specific issues in evolution. The anagenetic approach is criticized as axiological and frequently anthropocentric. Although the formation of grades can be useful. a sequence of grades must not be assumed to represent historical stages in the evolution of specific structures or behaviors. C1 UNIV MARYLAND,COLLEGE PK,MD 20742. RP CAMPBELL, CBG (reprint author), WALTER REED ARMY MED CTR,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307, USA. FU NEI NIH HHS [EY00735] NR 47 TC 16 Z9 17 U1 0 U2 7 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 SN 0735-7036 J9 J COMP PSYCHOL JI J. Comp. Psychol. PD SEP PY 1991 VL 105 IS 3 BP 211 EP 221 DI 10.1037/0735-7036.105.3.211 PG 11 WC Behavioral Sciences; Psychology; Psychology, Multidisciplinary; Zoology SC Behavioral Sciences; Psychology; Zoology GA GF681 UT WOS:A1991GF68100001 PM 1935002 ER PT J AU UNDERWOOD, JH KAPUSTA, AA AF UNDERWOOD, JH KAPUSTA, AA TI DEGRADATION AND FAILURE MODES OF CARBON BISMALEIMIDE LAMINATES SUBJECTED TO A TROPICAL ENVIRONMENT SO JOURNAL OF COMPOSITES TECHNOLOGY & RESEARCH LA English DT Note DE COMPOSITE LAMINATES; CARBON BISMALEIMIDE; SCANNING ELECTRON MICROSCOPY; FAILURE MECHANISMS; TROPICAL EXPOSURE AB The scanning electron microscope (SEM) was used to characterize the degradation of the outermost layers of carbon/bismaleimide laminates as the result of exposure to a natural tropical environment. The surface that was exposed to the sun for 4000 h suffered complete degradation of the bismaleimide matrix to a shallow depth. SEM fractography showed little difference in the fracture appearance of the fibers in a carbon/bismaleimide laminate, which displayed considerable fiber pullout, compared to fibers in a carbon/epoxy laminate, which displayed little pullout. RP UNDERWOOD, JH (reprint author), USA,ARMAMENT RES DEV & EDUC,BLDG 115,WATERVLIET,NY 12189, USA. NR 2 TC 3 Z9 3 U1 0 U2 0 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0884-6804 J9 J COMPOS TECH RES JI J. Compos. Technol. Res. PD FAL PY 1991 VL 13 IS 3 BP 179 EP 182 PG 4 WC Materials Science, Composites; Polymer Science SC Materials Science; Polymer Science GA GG632 UT WOS:A1991GG63200006 ER PT J AU SCHUBERT, FN AF SCHUBERT, FN TI UNITED-STATES-ARMY CORPS OF ENGINEERS AND AFGHANISTANS HIGHWAYS 1960-1967 SO JOURNAL OF CONSTRUCTION ENGINEERING AND MANAGEMENT-ASCE LA English DT Article AB The Corps of Engineers managed construction of nearly one-third of Afghanistan's modern road network. The Corps carried out the project, which took place in several segments over the period 1960-1967, through field offices in southern Asia. The effort was unusual for the Corps in that part of the world because it was strictly a civil project and had nothing to do with creation of military infrastructure. It also constituted the first face-to-face confrontation between American and Soviet foreign aid programs during the Cold War and was seen by American political leaders as a test of the national willingness to compete with the Soviets in a nonmilitary arena. The interconnection between diplomacy and construction continued for the duration of the program, and the border dispute between Afghanistan and Pakistan caused the greatest problems. In spite of this dispute and technical difficulties related to the stark Afghan topography and climate and the availability of construction materials, the program was a success. RP SCHUBERT, FN (reprint author), USA,CTR MIL HIST,BLDG 159,SE FED CTR,WASHINGTON,DC 20374, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9364 J9 J CONSTR ENG M ASCE JI J. Constr. Eng. Manage.-ASCE PD SEP PY 1991 VL 117 IS 3 BP 445 EP 459 DI 10.1061/(ASCE)0733-9364(1991)117:3(445) PG 15 WC Construction & Building Technology; Engineering, Industrial; Engineering, Civil SC Construction & Building Technology; Engineering GA GD594 UT WOS:A1991GD59400006 ER PT J AU GLASS, RG AF GLASS, RG TI WATER-PURIFICATION SYSTEMS AND RECOMMENDATIONS FOR FLUORIDE SUPPLEMENTATION SO JOURNAL OF DENTISTRY FOR CHILDREN LA English DT Article AB The recommended level of water fluoridation for optimal dental caries reduction is 0.7 ppm (mg/l) to 1.0 ppm, with 4.0 ppm being the maximum contaminant level allowed by the EPA. In communities that do not fluoridate water supplies, fluoride supplementation may be necessary. Guidelines are provided. This article also familarizes the reader with the types of water purification systems available, including eight types of point-of-use systems that remove fluoride from water. Dentists should ask patients about their drinking water to determine whether fluoride supplementation is needed. RP GLASS, RG (reprint author), USA,DENT CORP,WASHINGTON,DC 20310, USA. NR 6 TC 1 Z9 1 U1 0 U2 1 PU AMER SOC DENTISTRY CHILD PI CHICAGO PA 211 E CHICAGO AVE, CHICAGO, IL 60611 SN 0022-0353 J9 J DENT CHILD JI J. Dent. Child. PD SEP-OCT PY 1991 VL 58 IS 5 BP 405 EP 408 PG 4 WC Dentistry, Oral Surgery & Medicine; Pediatrics SC Dentistry, Oral Surgery & Medicine; Pediatrics GA GG762 UT WOS:A1991GG76200010 ER PT J AU COLE, MW ZAKAR, ES AF COLE, MW ZAKAR, ES TI RAPID PLAN VIEW TEM SAMPLE PREPARATION FOR SEMICONDUCTOR GRAIN-SIZE ANALYSIS SO JOURNAL OF ELECTRON MICROSCOPY TECHNIQUE LA English DT Note RP COLE, MW (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. NR 3 TC 3 Z9 3 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0741-0581 J9 J ELECTRON MICR TECH PD SEP PY 1991 VL 19 IS 1 BP 128 EP 129 DI 10.1002/jemt.1060190114 PG 2 WC Biology; Microscopy SC Life Sciences & Biomedicine - Other Topics; Microscopy GA GA397 UT WOS:A1991GA39700012 PM 1960568 ER PT J AU STUTZ, HK SILVERMAN, GJ ANGELINI, P LEVIN, RE AF STUTZ, HK SILVERMAN, GJ ANGELINI, P LEVIN, RE TI BACTERIA AND VOLATILE COMPOUNDS ASSOCIATED WITH GROUND-BEEF SPOILAGE SO JOURNAL OF FOOD SCIENCE LA English DT Article ID CHICKEN BREAST MUSCLE; CHILL TEMPERATURES; PSEUDOMONAS; GROWTH; STRAINS; MEAT; ACHROMOBACTER; STORAGE; AMINES; FOODS AB Ground beef (GB) samples were maintained in atmospheres of 2 or 18% oxygen. Similar putrid spoilage occurred at both concentrations, although the microflora differed. Two of 10 isolates from fresh and spoiled GB, nonfluorescent pseudomonads, produced putrid aromas but only 4 volatile compounds in common when inoculated into sterile GB. A Moraxella isolate produced a pronounced estery, decayed vegetable odor while others produced a decayed straw, ammoniacal or sour aroma. Differences in spoilage aromas apparently were not characterized by individual compounds but rather by the concentration of sulfur compounds and their ratio to other compound classes. Acetone, methyl ethyl ketone, dimethyl sulfide and dimethyl disulfide were indexes of microbial spoilage. C1 USA,NATICK RES DEV & ENG CTR,NATICK,MA 01760. UNIV MASSACHUSETTS,DEPT FOOD SCI & NUTR,AMHERST,MA 01003. NR 30 TC 28 Z9 29 U1 0 U2 15 PU INST FOOD TECHNOLOGISTS PI CHICAGO PA SUITE 300 221 N LASALLE ST, CHICAGO, IL 60601-1291 SN 0022-1147 J9 J FOOD SCI JI J. Food Sci. PD SEP-OCT PY 1991 VL 56 IS 5 BP 1147 EP 1153 DI 10.1111/j.1365-2621.1991.tb04721.x PG 7 WC Food Science & Technology SC Food Science & Technology GA GL080 UT WOS:A1991GL08000006 ER PT J AU PAYNE, BS MILLER, AC AF PAYNE, BS MILLER, AC TI THE STRUCTURE OF DOMINANT INVERTEBRATE ASSEMBLAGES IN A SMALL SOUTHEASTERN STREAM SO JOURNAL OF FRESHWATER ECOLOGY LA English DT Article AB Invertebrates were collected following near-average, extremely low, and above-average discharge in the winters of 1987, 1988, and 1989, respectively, in Luxapalila Creek, Mississippi and Alabama. Total invertebrate density was lower in pools (mean = 7,364, range = 5,427-12,561 individuals/sq m) than in riffles where it was also more variable (mean = 15,964, range = 9,662-28,820 individuals/sq m). There were no significant seasonal density differences among pools (p > 0.05). In samples collected during the fall, total density in riffles was two times higher than in pools. Following high discharge in December-February 1988-89, there were no significant density differences between pools and riffles. Interhabitat differences in chironomid and oligochaete species composition existed in Luxapalila Creek; seasonal periods of high water had a greater effect on invertebrates in riffles than pools. RP PAYNE, BS (reprint author), USA,ENGINEER WATERWAYS EXPT STN,ENVIRONM LAB,VICKSBURG,MS 39180, USA. NR 16 TC 7 Z9 7 U1 0 U2 0 PU OIKOS PUBL INC PI LA CROSSE PA PO BOX 2558, LA CROSSE, WI 54601 SN 0270-5060 J9 J FRESHWATER ECOL JI J. Freshw. Ecol. PD SEP PY 1991 VL 6 IS 3 BP 257 EP 266 DI 10.1080/02705060.1991.9665302 PG 10 WC Ecology; Limnology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA GN009 UT WOS:A1991GN00900004 ER PT J AU FORMAL, SB OAKS, EV OLSEN, RE WINGFIELDEGGLESTON, M SNOY, PJ COGAN, JP AF FORMAL, SB OAKS, EV OLSEN, RE WINGFIELDEGGLESTON, M SNOY, PJ COGAN, JP TI EFFECT OF PRIOR INFECTION WITH VIRULENT SHIGELLA-FLEXNERI 2A ON THE RESISTANCE OF MONKEYS TO SUBSEQUENT INFECTION WITH SHIGELLA-SONNEI SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID ESCHERICHIA-COLI; RHESUS-MONKEYS; PLASMID; PROTEINS; VACCINE AB All virulent shigellae have large plasmids. Plasmid-associated genes encode the expression of membrane-associated proteins (MAP), some of which correlate with the ability to invade susceptible epithelial cells. These MAP are serologically related in all of the shigella serotypes and evoke an antibody response after infection. To determine whether the MAP have a significant role in protection, 24 monkeys were infected with virulent Shigella flexneri 2a. After recovery, one group (with controls) was rechallenged with S. flexneri 2a; another group (with controls) was fed Shigella sonnei. The animals that were rechallenged with S. flexneri 2a were protected, while those that were fed S. sonnei experienced the same incidence of disease as controls. No differences in serum immune response to MAP after primary infection with S. flexneri were detected in immunoblots using lysates of S. flexneri or S. sonnei or in ELISA using water extracts of these strains. C1 US FDA,OFF BIOL,DIV PROD QUAL CONTROL,BETHESDA,MD 20014. RP FORMAL, SB (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTER INFECT,WASHINGTON,DC 20307, USA. NR 16 TC 80 Z9 80 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD SEP PY 1991 VL 164 IS 3 BP 533 EP 537 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA GB383 UT WOS:A1991GB38300014 PM 1869840 ER PT J AU ECHEVERRIA, P ORSKOV, F ORSKOV, I KNUTTON, S SCHEUTZ, F BROWN, JE LEXOMBOON, U AF ECHEVERRIA, P ORSKOV, F ORSKOV, I KNUTTON, S SCHEUTZ, F BROWN, JE LEXOMBOON, U TI ATTACHING AND EFFACING ENTEROPATHOGENIC ESCHERICHIA-COLI AS A CAUSE OF INFANTILE DIARRHEA IN BANGKOK SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID CLASSIC SEROTYPES; ADHERENCE FACTOR; HYBRIDIZATION; PATHOGENESIS; ADHESION; TOXIN; GENES AB To identify Escherichia coli that cause infantile diarrhea in Bangkok, Thailand, E. coli isolated in a year-long study of infantile diarrhea were examined for O and H serotypes and virulence determinants. Classic enteropathogenic E. coli (EPEC) were isolated from 28 of 509 infants with diarrhea (cases) and 11 of 509 age-matched controls (P = .009; odds ratio [OR], 2.64). Most of this difference was attributable to EPEC adherence factor (EAF)-positive EPEC that produced an attachment and effacement lesion, as identified in the fluorescence actin staining assay, isolated from 13 cases and 1 control (P = .003; OR, 13.3). EAF- EPEC was isolated from 15 cases and 10 controls (P = .418; OR, 1.52) and EAF+ non-EPEC from 17 cases and 10 controls (P = .242; OR, 1.72). EAF+ EPEC that caused an attachment and effacement lesion was found in 3% of children < 6 months old with diarrhea who were studied in an outpatient clinic in Bangkok in 1988. C1 ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. STATENS SERUM INST,INT ESCHERICHIA & KLEBSIELLA CTR,DK-2300 COPENHAGEN,DENMARK. CHILDRENS HOSP,BANGKOK,THAILAND. UNIV BIRMINGHAM,INST CHILD HLTH,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND. OI Scheutz, Flemming/0000-0002-3931-4846 NR 25 TC 57 Z9 58 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD SEP PY 1991 VL 164 IS 3 BP 550 EP 554 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA GB383 UT WOS:A1991GB38300017 PM 1678401 ER PT J AU WATT, G SHANKS, GD EDSTEIN, MD PAVANAND, K WEBSTER, HK WECHGRITAYA, S AF WATT, G SHANKS, GD EDSTEIN, MD PAVANAND, K WEBSTER, HK WECHGRITAYA, S TI CIPROFLOXACIN TREATMENT OF DRUG-RESISTANT FALCIPARUM-MALARIA SO JOURNAL OF INFECTIOUS DISEASES LA English DT Note ID PLASMODIUM-FALCIPARUM; PHARMACOKINETICS AB A randomized, open study of high-dose ciprofloxacin (750 mg every 12 h) in uncomplicated falciparum malaria was conducted in Thailand. No patient completed the planned 1-week treatment course. Because of rising parasitemia (threefold higher at 36 h than on admission) and deterioration of clinical status, three individuals required quinine treatment 36 h after commencing ciprofloxacin; a fourth was given quinine at 54 h. The study was terminated early for safety reasons after only four ciprofloxacin and four control patients had been enrolled. Ciprofloxacin was well absorbed and efficiently entered erythrocytes; median plasma and red cell concentrations 90 min after the first dose were 4.0 (range, 3.7-6.8) and 5.1 (3.8-6.0) mu-g/ml, respectively. However, 50% inhibition of parasite growth in vitro required 6.6-mu-g/ml (5.6-9.6). Ciprofloxacin should not be used alone to treat chloroquine-resistant falciparum malaria. C1 ARMED FORCES RES INST MED SCI,DEPT MED,BANGKOK,THAILAND. SURASINGHANART ARMY HOSP,ARANYAPRATHET,THAILAND. ARMED FORCES RES INST MED SCI,DEPT IMMUNOL,BANGKOK,THAILAND. RI Shanks, George Dennis/F-4056-2014 OI Shanks, George Dennis/0000-0001-5763-8660 NR 16 TC 34 Z9 35 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD SEP PY 1991 VL 164 IS 3 BP 602 EP 604 PG 3 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA GB383 UT WOS:A1991GB38300027 PM 1869847 ER PT J AU MORRIS, JT BECKIUS, M MCALLISTER, CK AF MORRIS, JT BECKIUS, M MCALLISTER, CK TI SPOROBOLOMYCES INFECTION IN AN AIDS PATIENT SO JOURNAL OF INFECTIOUS DISEASES LA English DT Letter RP MORRIS, JT (reprint author), USA,MED CORPS,BROOKE ARMY MED CTR,DEPT MED,INFECT DIS SERV,FT SAM HOUSTON,TX 78234, USA. NR 4 TC 20 Z9 22 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD SEP PY 1991 VL 164 IS 3 BP 623 EP 624 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA GB383 UT WOS:A1991GB38300043 PM 1869859 ER PT J AU SCHULZE, TL TAYLOR, GC JORDAN, RA BOSLER, EM SHISLER, JK AF SCHULZE, TL TAYLOR, GC JORDAN, RA BOSLER, EM SHISLER, JK TI EFFECTIVENESS OF SELECTED GRANULAR ACARICIDE FORMULATIONS IN SUPPRESSING POPULATIONS OF IXODES-DAMMINI (ACARI, IXODIDAE) - SHORT-TERM CONTROL OF NYMPHS AND LARVAE SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE ARACHNIDA; IXODES-DAMMINI; ACARICIDES; LYME DISEASE ID AMBLYOMMA-AMERICANUM ACARI; LYME-DISEASE; NEW-JERSEY; AREA CONTROL; TICKS; HOSTS AB Applications of selected granular acaricide formulations to the shrub layer of forested habitats during the peak activity periods of Ixodes dammini Spielman, Clifford, Piesman & Corwin nymphs and larvae significantly reduced the abundance of these stages on Peromyscus leucopus. The granules effectively penetrated growing vegetation and suppressed populations of subadult ticks questing in the leaf litter. The use of granular acaricide formulations provides the only documented method of control of free-living I. dammini nymphs and larvae in dense vegetation. As such, this technique will serve as a major component of any integrated control program against this vector tick species. C1 USA,MEDDAC,PREVENT MED SERV,ENVIRONM HLTH SECT,FT MONMOUTH,NJ 07703. ENVIRONM CONNECT INC,FREEHOLD,NJ 07728. SUNY STONY BROOK,NEW YORK STATE DEPT HLTH,HLTH SCI CTR,STONY BROOK,NY 11794. RP SCHULZE, TL (reprint author), NEW JERSEY STATE DEPT HLTH,CN 369,DIV EPIDEMIOL & COMMUNICABLE DIS CONTROL,TRENTON,NJ 08625, USA. NR 14 TC 43 Z9 43 U1 0 U2 5 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD SEP PY 1991 VL 28 IS 5 BP 624 EP 629 PG 6 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA GG448 UT WOS:A1991GG44800011 PM 1941929 ER PT J AU SNYDER, AP MILLER, M SHOFF, DB EICEMAN, GA BLYTH, DA PARSONS, JA AF SNYDER, AP MILLER, M SHOFF, DB EICEMAN, GA BLYTH, DA PARSONS, JA TI ENZYME-SUBSTRATE ASSAY FOR THE QUALITATIVE DETECTION OF MICROORGANISMS BY ION MOBILITY SPECTROMETRY SO JOURNAL OF MICROBIOLOGICAL METHODS LA English DT Article DE ESCHERICHIA-COLI; FECAL COLIFORM; BETA-GALACTOSIDASE; ION MOBILITY SPECTROMETRY; ORTHO-NITROPHENOL; ORTHO-NITROPHENYL-BETA-D-GALACTOPYRANOSIDE ID FECAL COLIFORMS; WATER; IDENTIFICATION AB A relatively new concept is explored where the potential for ion mobility spectrometry (IMS) is investigated for the detection and determination of living microorganisms. A hand-held IMS instrument embodies the analytical concept and is an atmospheric pressure vapor detector. Neutral vapor analytes are ionized by a Ni-63 ring and the ions' time of flight in an atmospheric pressure drift tube are recorded. Advantage is taken of the inherent enzymes found in microorganisms and an exogenous tailored substrate was provided to initiate the desired biochemical reaction. The substrate was ortho-nitrophenyl-beta-D-galactopyranoside, and the product, ortho-nitrophenol (ONP), has a considerable vapor pressure. ONP can be detected in the negative ion mode of the IMS which indirectly signals the presence of bacteria. Detection limits of almost-equal-to 10(4) Escherichia coli bacterial cells in 5 min and 3300 E. coli cells in 15 min were realized. The results suggest a new application of IMS in the screening of bacterial contamination in community water and wastewater testing situations. C1 NEW MEXICO STATE UNIV,LAS CRUCES,NM 88003. RP SNYDER, AP (reprint author), USA,CTR CHEM RES DEV & ENGN,GEO CTR INC,ABERDEEN PROVING GROUND,MD 21010, USA. NR 24 TC 12 Z9 12 U1 1 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-7012 J9 J MICROBIOL METH JI J. Microbiol. Methods PD SEP PY 1991 VL 14 IS 1 BP 21 EP 32 DI 10.1016/0167-7012(91)90004-A PG 12 WC Biochemical Research Methods; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA GL788 UT WOS:A1991GL78800003 ER PT J AU ASCHER, DP WILSON, S MENDIOLA, J FISCHER, GW AF ASCHER, DP WILSON, S MENDIOLA, J FISCHER, GW TI GROUP-B STREPTOCOCCAL LATEX AGGLUTINATION TESTING IN NEONATES SO JOURNAL OF PEDIATRICS LA English DT Article ID ANTIGEN C1 WALTER REED ARMY MED CTR, DEPT PEDIAT NEONATOL, WASHINGTON, DC 20307 USA. UNIV TEXAS, HERMANN HOSP, SCH MED, DEPT PEDIAT NEONATOL, HOUSTON, TX 77030 USA. RP ASCHER, DP (reprint author), UNIFORMED SERV UNIV HLTH SCI, DEPT PEDIAT, 4301 JONES BRIDGE RD, BETHESDA, MD 20814 USA. NR 9 TC 14 Z9 14 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 EI 1097-6833 J9 J PEDIATR-US JI J. Pediatr. PD SEP PY 1991 VL 119 IS 3 BP 458 EP 461 DI 10.1016/S0022-3476(05)82063-3 PG 4 WC Pediatrics SC Pediatrics GA GE057 UT WOS:A1991GE05700020 PM 1880662 ER PT J AU HICKEY, JS ONEAL, RB SCHEIDT, MJ STRONG, SL TURGEON, D VANDYKE, TE AF HICKEY, JS ONEAL, RB SCHEIDT, MJ STRONG, SL TURGEON, D VANDYKE, TE TI MICROBIOLOGIC CHARACTERIZATION OF LIGATURE-INDUCED PERI-IMPLANTITIS IN THE MICROSWINE MODEL SO JOURNAL OF PERIODONTOLOGY LA English DT Article DE PERIODONTAL DISEASES MICROBIOLOGY; PERI-IMPLANTITIS MICROBIOLOGY; BONE LOSS; OSSEOINTEGRATION; DENTAL IMPLANTS ID MINIATURE SWINE; MUCOGINGIVAL DEFECTS AB THE PURPOSE OF THIS STUDY WAS TO EVALUATE the microbiologic changes associated with induction of peri-implantitis in the microswine. A split-mouth design was utilized. Three implants were placed in the edentulous mandibular bicuspid region of 2 microswine yielding 12 implants for evaluation. The experimental implant abutments were ligated with 4-0 silk suture material to induce peri-implantitis for a period of 45 days. The control implant abutments were not ligated. The control implants were scaled and cleaned at each time interval using plastic scalers. The attachment level (AL), probing depth (PD), gingival index (GI), and plaque index (PI) were measured at day 0 (baseline) and days 14 and 45. Microbiologic samples were taken from the "sulcus" with paper points at each interval and were dispersed in prereduced media; plated on selective and non-selective media; and grown under aerobic, anaerobic, and capnophilic atmospheres. A greater AL, increased PD, and higher GI and PI scores were noted among the experimental implants. The controls remained essentially unchanged. Radiographs revealed that experimental implants showed an increased amount of bone loss when compared to control. Bone loss caused the implant threads to be exposed in the experimental implants. Microbiologic studies revealed that there was a shift from Gram-positive facultative organisms to Gram-negative obligate anaerobes, including black pigmented Bacteroides, in experimental implants. The microbiota of the control implants remained primarily Gram-positive facultative organisms. The microswine appears to be a suitable animal model for evaluation of osseointegrated implants. Importantly, under the experimental conditions reported, osseointegrated implants were susceptible to "periodontal" breakdown or peri-implantitis. C1 EMORY UNIV,ATLANTA,GA 30322. RP HICKEY, JS (reprint author), USA,DENT ACTIV,PERIODONTAL RESIDENCY PROGRAM,FT GORDON,GA 30905, USA. FU NIDCR NIH HHS [DE06436, DE07908] NR 32 TC 44 Z9 46 U1 0 U2 3 PU AMER ACAD PERIODONTOLOGY PI CHICAGO PA 737 NORTH MICHIGAN AVENUE, SUITE 800, CHICAGO, IL 60611-2690 SN 0022-3492 J9 J PERIODONTOL JI J. Periodont. PD SEP PY 1991 VL 62 IS 9 BP 548 EP 553 PG 6 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA GF544 UT WOS:A1991GF54400002 PM 1941494 ER PT J AU NOSAL, G SCHEIDT, MJ ONEAL, R VANDYKE, TE AF NOSAL, G SCHEIDT, MJ ONEAL, R VANDYKE, TE TI THE PENETRATION OF LAVAGE SOLUTION INTO THE PERIODONTAL POCKET DURING ULTRASONIC INSTRUMENTATION SO JOURNAL OF PERIODONTOLOGY LA English DT Article DE DENTAL PLAQUE PREVENTION AND CONTROL; DENTAL CALCULUS PREVENTION AND CONTROL; ULTRASONICS; PERIODONTAL POCKETS DRUG THERAPY; DENTAL INSTRUMENTS ID SUBGINGIVAL PLAQUE; ANTIMICROBIAL IRRIGATION; DEEP POCKETS; DISEASE; AGENTS; DEPTH AB THE PURPOSE OF THIS STUDY WAS TO evaluate the penetration depth of the water coolant for medicament lavage of an ultrasonic device into the periodontal pocket. Patients having teeth previously planned for extraction, and exhibiting probing depths 3 mm or greater were used in this study. A reference notch was placed on the tooth at the level of the gingival margin and the probing attachment level (PAL) was measured from the base of the notch to the base of the pocket. The ultrasonic device, with an EWPP tip and equipped with a reservoir of erythrocin dye colored coolant, was activated and moved in a vertical direction from the gingival margin to the apical extent of the pocket. The tooth was extracted and the penetration depth (PD) of the dye-colored water spray was measured from the reference notch to the apical limit of the stained subgingival plaque. The tooth was counter stained with methylene blue to determine the coronal extent of the connective tissue attachment. Pearsons' Product Moment Correlation Coefficient for the PAL and PD was calculated. Dye-stained root surface was observed along the full extent of the probe tip's penetration path. The dispersion of the dye-colored stain was localized to the area of the ultrasonic probe with very little lateral dispersion. The ultrasonic instrument may be an effective system to mechanically remove plaque and calculus at the same time as delivering a chemotherapeutic agent. The limited dispersion of the liquid dye would indicate that chemical plaque control with this delivery system is dependent upon thorough debridement with the instrument such that all affected surfaces are instrumented. C1 EMORY UNIV,ATLANTA,GA 30322. RP NOSAL, G (reprint author), USA,DENT ACTIV,PERIODONTAL RESIDENCY PROGRAM,FT GORDON,GA 30905, USA. FU NIDCR NIH HHS [DE06436, DE07908] NR 17 TC 20 Z9 24 U1 0 U2 0 PU AMER ACAD PERIODONTOLOGY PI CHICAGO PA 737 NORTH MICHIGAN AVENUE, SUITE 800, CHICAGO, IL 60611-2690 SN 0022-3492 J9 J PERIODONTOL JI J. Periodont. PD SEP PY 1991 VL 62 IS 9 BP 554 EP 557 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA GF544 UT WOS:A1991GF54400003 PM 1658291 ER PT J AU PITCHFORD, JH AF PITCHFORD, JH TI A REEVALUATION OF THE AXIS-ORBITAL PLANE AND THE USE OF ORBITALE IN A FACEBOW TRANSFER RECORD SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article ID POINT AB A fundamental assumption in prosthetic dentistry is that the axis-orbital plane usually will be parallel to the reference horizontal. Most articulator systems have incorporated this concept into their designs and use orbitale as the anterior reference point for transferring the vertical position of the maxillae to the articulator. The position of the maxillary cast is expected to be in the same vertical position as the maxillae with the subject's head oriented in the esthetic reference position. However, the use of orbitale in conjunction with an articulator whose design assumption places the axis and orbital indicator parallel to the horizontal reference will result in a substantial mounting error. This article examines the cause and correction of the mounting error that results from the use of orbitale as the anterior reference point of a facebow transfer record made to an axis-orbital designed articulator. C1 USA,WASHINGTON,DC 20310. NR 11 TC 16 Z9 17 U1 0 U2 2 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD SEP PY 1991 VL 66 IS 3 BP 349 EP 355 DI 10.1016/0022-3913(91)90262-U PG 7 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA GD337 UT WOS:A1991GD33700014 PM 1800732 ER PT J AU IVANHOE, JR ADRIAN, ED KRANTZ, WA EDGE, MJ AF IVANHOE, JR ADRIAN, ED KRANTZ, WA EDGE, MJ TI AN IMPRESSION TECHNIQUE FOR OSSEOINTEGRATED IMPLANTS SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Note C1 USA,DENTAC,REMOVABLE PROSTHODONT SERV,FT GORDON,GA 30905. USA,DENTAC,PROSTHODONT RESIDENCY PROGRAM,FT GORDON,GA 30905. USA,DENTAC,FIXED PROSTHODONT SERV,FT GORDON,GA 30905. RP IVANHOE, JR (reprint author), EMORY UNIV,SCH POSTGRAD DENT,DEPT PROSTHODONT,1462 CLIFTON RD NE,ATLANTA,GA 30322, USA. NR 2 TC 21 Z9 23 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD SEP PY 1991 VL 66 IS 3 BP 410 EP 411 DI 10.1016/0022-3913(91)90273-Y PG 2 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA GD337 UT WOS:A1991GD33700025 PM 1800742 ER PT J AU LEEK, MR HANNA, TE MARSHALL, L AF LEEK, MR HANNA, TE MARSHALL, L TI AN INTERLEAVED TRACKING PROCEDURE TO MONITOR UNSTABLE PSYCHOMETRIC FUNCTIONS SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID ADAPTIVE PSYCHOPHYSICAL PROCEDURES AB In some experimental situations, the psychometric function underlying performance may not be stable, but instead may shift along the stimulus axis in response to changes in attention, learning, or task difficulty. When this occurs, the measured threshold may be influenced and the slope of the measured function will be inaccurately shallow. With commonly used experimental procedures, it is difficult to know whether a shallow psychometric function slope is a true reflection of the sensory process, or is a result of "averaging" a highly variable underlying function. Here, a new method is described of estimating psychometric function slope from the variability in two interleaved adaptive tracks, consulted on alternate trials, that is resistant to the effects of shifting performance levels. Further, a mechanism is described for assessing the likelihood that a threshold was, in fact, stable over the course of its measurement. Computer simulations are reported as well as verification of the method in measurements of human performance on a psychophysical task. Several conditions of externally imposed variability were simulated to establish the ability of these procedures to identify unstable functions and produce accurate slope estimates. The procedures worked well for thresholds shifting by as little as 4 dB if the variation did not occur too rapidly. The procedure and associated analyses are recommended as a relatively "free" means of calculating slope and quantifying threshold reliability with little extra experimental effort. C1 USN,SUBMARINE MED RES LAB,GROTON,CT 06349. RP LEEK, MR (reprint author), WALTER REED ARMY MED CTR,CTR AUDIOL & SPEECH,WASHINGTON,DC 20307, USA. NR 10 TC 13 Z9 13 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD SEP PY 1991 VL 90 IS 3 BP 1385 EP 1397 DI 10.1121/1.401930 PG 13 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA GE466 UT WOS:A1991GE46600018 PM 1939903 ER PT J AU SMITH, KJ SKELTON, HG JAMES, WD ANGRITT, P AF SMITH, KJ SKELTON, HG JAMES, WD ANGRITT, P TI CONCURRENT EPIDERMAL INVOLVEMENT OF CYTOMEGALOVIRUS AND HERPES-SIMPLEX VIRUS IN 2 HIV-INFECTED PATIENTS SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID ACQUIRED-IMMUNODEFICIENCY-SYNDROME; ACID-FAST BACILLI; INCLUSION DISEASE; AIDS PATIENT; SKIN; LESIONS AB Although cytomegalovirus has previously been reported in cutaneous lesions of patients infected with the human immunodeficiency virus, these reports are not common despite the prevalence of this infection and the significant pathologic characteristics that it induces in HIV disease. Rare reports of possible epidermal involvement by cytomegalovirus have never been fully documented and have been believed by some to represent epidermal involvement by varicella-zoster and/or herpes simplex infections, with dermal involvement of cytomegalovirus. We present two cases of concurrent epidermal involvement by cytomegalovirus and herpes simplex virus documented by immunohistochemical studies and DNA hybridization studies and correlate this with the distinctive morphologic features seen in these two viral infections on routine staining. C1 ARMED FORCES INST PATHOL,DEPT DERMATOPATHOL,WASHINGTON,DC 20306. WALTER REED ARMY MED CTR,DEPT DERMATOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 23 TC 30 Z9 30 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD SEP PY 1991 VL 25 IS 3 BP 500 EP 506 DI 10.1016/0190-9622(91)70230-Y PG 7 WC Dermatology SC Dermatology GA GD340 UT WOS:A1991GD34000005 PM 1655836 ER PT J AU GUTHRIE, RC DIFIORE, PM AF GUTHRIE, RC DIFIORE, PM TI TREATING THE CRACKED TOOTH WITH A FULL CROWN SO JOURNAL OF THE AMERICAN DENTAL ASSOCIATION LA English DT Article AB Twenty-eight teeth diagnosed as having a crack were immediately treated with full coverage acrylic resin crowns. Twenty-five of these teeth became asymptomatic after full coverage acrylic crown placement and continued to be asymptomatic one year after restoration. C1 USA,DENT DENTAC,FT MCCLELLAN,AL 36205. NR 23 TC 5 Z9 6 U1 0 U2 3 PU AMER DENTAL ASSN PI CHICAGO PA 211 E CHICAGO AVE, CHICAGO, IL 60611 SN 0002-8177 J9 J AM DENT ASSOC JI J. Am. Dent. Assoc. PD SEP PY 1991 VL 122 IS 10 BP 71 EP 73 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA GF112 UT WOS:A1991GF11200017 PM 1918671 ER PT J AU LOGAN, TM LINTHICUM, KJ THANDE, PC WAGATEH, JN ROBERTS, CR AF LOGAN, TM LINTHICUM, KJ THANDE, PC WAGATEH, JN ROBERTS, CR TI MOSQUITO SPECIES COLLECTED FROM A MARSH IN WESTERN KENYA DURING THE LONG RAINS SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article ID RIFT-VALLEY FEVER; DAMBO; VIRUS AB A total of 475,431 mosquitoes representing 8 genera and 43 species were collected from a marsh in the western Kenya highlands to determine species composition and succession in relation to the epidemiology of Rift Valley fever virus. Culex pipiens was the most common species, totalling 92.3% of the collection, followed by Cx. zombaensis (2.2%), Anopheles coustani (1.1%), An. squamosus (0.8%). Mansonia uniformis (0.6%), Coquillettidia microannulatus (0.5%), Uranotaenia mashonaensis (0.5%), Ma. africana (0.4%) and Cq. aurites (0.4%). Aedes quasiunivittatus was the first floodwater species to emerge from newly flooded areas and was the most abundant Aedes collected, representing 88% of all Aedes specimens. Culex guiarti and Cx. zombaensis colonized newly flooded areas soon after the areas became flooded. C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. RP LOGAN, TM (reprint author), USA,MED RES UNIT KENYA,BOX 401,APO,NEW YORK,NY 09675, USA. NR 17 TC 13 Z9 13 U1 0 U2 3 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD SEP PY 1991 VL 7 IS 3 BP 395 EP 399 PG 5 WC Entomology SC Entomology GA GM633 UT WOS:A1991GM63300006 PM 1686445 ER PT J AU GORDON, SW TAMMARIELLO, RF LINTHICUM, KJ WIRTZ, RA DIGOUTTE, JP AF GORDON, SW TAMMARIELLO, RF LINTHICUM, KJ WIRTZ, RA DIGOUTTE, JP TI FEEDING PATTERNS OF MOSQUITOS COLLECTED IN THE SENEGAL RIVER BASIN SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article ID RIFT-VALLEY FEVER; HOST SELECTION PATTERNS; ANOPHELES-PHAROENSIS; WEST-AFRICA; KENYA; DIPTERA; MAURITANIA; CULICIDAE; EPIDEMIC AB Mosquitoes were collected with light traps baited with dry ice at 16 locations in Senegal during the rainy season of 1988. Of 62,055 mosquitoes identified. 1,384 (2.2%), representing 25 species in 4 genera, were bloodfed. Mosquito bloodmeals were screened by enzyme-linked immunosorbent assay against antisera to humans, bovines, goats, sheep and chickens. Overall, 88% of the bloodmeals tested were identified. Bloodmeals from 5 species of Culex mosquitoes comprised 82% of the number tested. Culex antennatus (36.6%) and Cx. tritaeniorhyncus (33.5%) were the most abundant. All Culex except those of the Cx. univittatus group fed most often on humans, Aedes species fed almost equally on all mammals tested, while species of Anopheles preferred cattle over humans, goats and sheep. RP GORDON, SW (reprint author), USA,MED RES INST,FREDERICK,MD 21702, USA. RI Gordon, Scott/B-8875-2011 NR 34 TC 10 Z9 10 U1 1 U2 1 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD SEP PY 1991 VL 7 IS 3 BP 424 EP 432 PG 9 WC Entomology SC Entomology GA GM633 UT WOS:A1991GM63300012 PM 1686446 ER PT J AU KLEIN, TA HARRISON, BA DIXON, SV BURGE, JR AF KLEIN, TA HARRISON, BA DIXON, SV BURGE, JR TI COMPARATIVE SUSCEPTIBILITY OF SOUTHEAST-ASIAN ANOPHELES-MOSQUITOS TO THE SIMIAN MALARIA PARASITE PLASMODIUM-CYNOMOLGI SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article ID CYTOGENETIC EVIDENCE; CULICIDAE; THAILAND; DIPTERA; PHILIPPINENSIS; TRANSMISSION; INFECTION; NIVIPES; DIRUS AB Seven Anopheles species/isolates were compared with Anopheles dirus (control) for susceptibility to Plasmodium cynomolgi B strain. The mean numbers of oocysts in paired replicates of An. dirus and An. takasagoensis were not significantly different. The remaining test species had significantly fewer mean numbers of oocysts than Anopheles dirus (P < 0.01). Anopheles dirus had the highest percentage of mosquitoes infected with P. cynomolgi sporozoites (82%). Of the test groups, Anopheles dirus B and An. takasagoensis had the highest percentage of mosquitoes with sporozoites, 77 and 78%, respectively. Fewer than 50% of Anopheles maculatus E and An. maculatus B (NN isolate) had sporozoites in the salivary glands. Anopheles maculatus B (HK isolate) and Anopheles philippinensis were the least susceptible, with fewer than 30% having sporozoites in the salivary glands. C1 USA,MED COMPONENT,AFRIMS,APO,SAN FRANCISCO,CA 96346. NR 31 TC 6 Z9 7 U1 0 U2 0 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD SEP PY 1991 VL 7 IS 3 BP 481 EP 487 PG 7 WC Entomology SC Entomology GA GM633 UT WOS:A1991GM63300022 PM 1791460 ER PT J AU GUPTA, RK RUTLEDGE, LC AF GUPTA, RK RUTLEDGE, LC TI CONTROLLED RELEASE REPELLENT FORMULATIONS ON HUMAN VOLUNTEERS UNDER 3 CLIMATIC REGIMENS SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Note ID MOSQUITOS; FIELD AB Two controlled-release repellent formulations containing 33% (3M) and 42% (Biotek) deet and an Army repellent containing 75% deet were evaluated in 3 different climatic regimens (tropical forested, tropical open and basic hot environments). The 3 repellents provided similar protection for different time periods after application under all 3 climates against Aedes aegypti, Ae. taeniorhynchus and Anopheles stephensi whereas there was no difference in protection period against An. albimanus. RP GUPTA, RK (reprint author), USA,BIOMED RES & DEV LAB,DIV FIELD MED MAT DEV,FREDERICK,MD 21702, USA. NR 8 TC 18 Z9 19 U1 0 U2 0 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD SEP PY 1991 VL 7 IS 3 BP 490 EP 493 PG 4 WC Entomology SC Entomology GA GM633 UT WOS:A1991GM63300024 PM 1791462 ER PT J AU GALBICKA, G FOWLER, KP RITCH, ZJ AF GALBICKA, G FOWLER, KP RITCH, ZJ TI CONTROL OVER RESPONSE NUMBER BY A TARGETED PERCENTILE SCHEDULE - REINFORCEMENT LOSS AND THE ACUTE EFFECTS OF D-AMPHETAMINE SO JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR LA English DT Article DE PERCENTILE SCHEDULES; RESPONSE DIFFERENTIATION; FIXED CONSECUTIVE NUMBER SCHEDULES; RESPONSE NUMBER; REINFORCEMENT LOSS; D-AMPHETAMINE; LEVER PRESS; RATS ID EXTERNAL DISCRIMINATIVE STIMULUS; BEHAVIOR; CONTINGENCY; PIGEONS; SHOCK; RATS AB Two fixed-consecutive-number-like procedures were used to examine effects of acute d-amphetamine administration on control over response number. In both procedures, rats were required to press the left lever at least once and then press the right lever to complete a trial. The consecutive left-lever presses on each trial comprised a "run." Under the targeted percentile schedule, reinforcement was provided if the current run length was closer to the target length (16) than half of the most recent 24 runs. This differentially reinforced run length while holding reinforcement probability constant at .5. A second group acquired the differentiation under the targeted percentile schedule, but were then shifted to a procedure that yoked reinforcement probability by subject and run length to that obtained under the targeted percentile schedule. The two procedures generated practically identical control run lengths, response rates, reinforcement probabilities, and reinforcement rates. Administration of d-amphetamine disrupted percentile responding to a greater degree than yoked control responding. This disruption decreased reinforcement frequency less in the former than the latter procedure. The similar baseline responding under these two procedures suggests that this difference in sensitivity was due to behavioral adjustments to drug prompted by reduction of reinforcement density in the yoked control but not the percentile schedule. These adjustments attenuate the drug's effects under the former, but not the latter, procedure. RP GALBICKA, G (reprint author), WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,WASHINGTON,DC 20307, USA. NR 24 TC 11 Z9 11 U1 0 U2 0 PU SOC EXP ANALYSIS BEHAVIOR INC PI BLOOMINGTON PA INDIANA UNIV DEPT PSYCHOLOGY, BLOOMINGTON, IN 47405 SN 0022-5002 J9 J EXP ANAL BEHAV JI J. Exp. Anal. Behav. PD SEP PY 1991 VL 56 IS 2 BP 205 EP 215 DI 10.1901/jeab.1991.56-205 PG 11 WC Psychology, Biological; Behavioral Sciences; Psychology, Experimental SC Psychology; Behavioral Sciences GA GG116 UT WOS:A1991GG11600005 PM 1955813 ER PT J AU HURSH, SR AF HURSH, SR TI BEHAVIORAL ECONOMICS OF DRUG SELF-ADMINISTRATION AND DRUG-ABUSE POLICY SO JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR LA English DT Article DE BEHAVIORAL ECONOMICS; DEMAND CURVE; ELASTICITY; DRUG SELF-ADMINISTRATION; COST; UNIT PRICE; FR SCHEDULE; PUBLIC POLICY; DESIGN OF CULTURE ID RATIO SCHEDULES; RHESUS-MONKEYS; INFERIOR-GOOD; GIFFEN-GOOD; DEMAND; FOOD AB The concepts of behavioral economics have proven useful for understanding the environmental control of overall levels of responding for a variety of commodities, including reinforcement by drug self-administration. These general concepts are summarized for application to the analysis of drug-reinforced behavior and proposed as the basis for future applications. This behavioral agenda includes the assessment of abuse liability, the assay of drug-reinforcer interactions, the design of drug abuse interventions, and the formulation of drug abuse public policy. These separate domains of investigation are described as part of an overall strategy for designing model projects to control drug use and testing public policy initiatives. RP HURSH, SR (reprint author), WALTER REED ARMY MED CTR,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307, USA. NR 36 TC 108 Z9 108 U1 1 U2 6 PU SOC EXP ANALYSIS BEHAVIOR INC PI BLOOMINGTON PA INDIANA UNIV DEPT PSYCHOLOGY, BLOOMINGTON, IN 47405 SN 0022-5002 J9 J EXP ANAL BEHAV JI J. Exp. Anal. Behav. PD SEP PY 1991 VL 56 IS 2 BP 377 EP 393 DI 10.1901/jeab.1991.56-377 PG 17 WC Psychology, Biological; Behavioral Sciences; Psychology, Experimental SC Psychology; Behavioral Sciences GA GG116 UT WOS:A1991GG11600017 PM 1955823 ER PT J AU AHRENS, JP WARD, DL AF AHRENS, JP WARD, DL TI PERFORMANCE OF BERMED REVETMENTS SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Note C1 USA,COAST ENGN RES CTR,WATERWAYS EXPT STN,VICKSBURG,MS 39180. RP AHRENS, JP (reprint author), NOAA,NATL SEA GRANT COLL PROGRAM,1335 E W HIGHWAY,SILVER SPRING,MD 20910, USA. NR 12 TC 2 Z9 2 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD SEP-OCT PY 1991 VL 117 IS 5 BP 534 EP 540 DI 10.1061/(ASCE)0733-950X(1991)117:5(534) PG 7 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA GD588 UT WOS:A1991GD58800006 ER PT J AU HAMMACK, J SCHEFFNER, N SEGUR, H AF HAMMACK, J SCHEFFNER, N SEGUR, H TI STEM WAVES ALONG BREAKWATER - DISCUSSION SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Discussion ID PERIODIC-WAVES; SHALLOW-WATER C1 COAST ENGINEERS RES CTR,WATERWAYS EXPT STN,VICKSBURG,MS 39180. RP HAMMACK, J (reprint author), UNIV FLORIDA,DEPT AEROSPACE ENGN MECH & ENGN SCI,GAINESVILLE,FL 32611, USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD SEP-OCT PY 1991 VL 117 IS 5 BP 542 EP 543 DI 10.1061/(ASCE)0733-950X(1991)117:5(542) PG 2 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA GD588 UT WOS:A1991GD58800007 ER PT J AU CHEEK, JB AF CHEEK, JB TI THE PRICE TAG FOR A FAST FOURIER-TRANSFORM ON ANY SAMPLE-SIZE SO MECHANICAL SYSTEMS AND SIGNAL PROCESSING LA English DT Article RP CHEEK, JB (reprint author), USA,CORPS ENGINEERS,WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0888-3270 J9 MECH SYST SIGNAL PR JI Mech. Syst. Signal Proc. PD SEP PY 1991 VL 5 IS 5 BP 357 EP 366 DI 10.1016/0888-3270(91)90002-M PG 10 WC Engineering, Mechanical SC Engineering GA GF135 UT WOS:A1991GF13500002 ER PT J AU TAYLOR, S BROWNLEE, DE AF TAYLOR, S BROWNLEE, DE TI COSMIC SPHERULES IN THE GEOLOGIC RECORD SO METEORITICS LA English DT Article ID DEEP-SEA SEDIMENTS; MASS-DISTRIBUTION; GREENLAND; ORIGIN; DUST AB Cosmic spherules obtained from the Greenland ice cap, deep-sea sediments, and ancient oceanic deposits of Eocene and Jurassic age were chemically and texturally compared. The proportions of spherule types were found to change as a function of time, with the number of iron spherules increasing as the age of the sample increased. It is not yet possible, however, to determine if the variation in spherule types represents a real change in the meteoroid complex or is a result of differential weathering of the spherules in the Earth's environment. The age of these spherules ranges from less than 3000 years to about 190 million years. Although only a few spherules older than 500 000 years are chemically unaltered, textural information is available even from the oldest spherules and, by comparison with contemporary spherules, gives some insight into the original compositions of the particles. C1 UNIV WASHINGTON,DEPT ASTRON,SEATTLE,WA 98195. RP TAYLOR, S (reprint author), USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 28 TC 61 Z9 65 U1 2 U2 3 PU METEORITICAL SOC PI FAYETTEVILLE PA DEPT CHEMISTRY/BIOCHEMISTRY, UNIV ARKANSAS, FAYETTEVILLE, AR 72701 SN 0026-1114 J9 METEORITICS JI Meteoritics PD SEP PY 1991 VL 26 IS 3 BP 203 EP 211 PG 9 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA GL893 UT WOS:A1991GL89300003 ER PT J AU HERRINGTON, T AF HERRINGTON, T TI MULTIPLICITY IN THE MILITARY SO MILITARY LAW REVIEW LA English DT Article RP HERRINGTON, T (reprint author), USA,WASHINGTON,DC 20310, USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1991 VL 134 BP 45 EP 85 PG 41 WC Law SC Government & Law GA GX767 UT WOS:A1991GX76700002 ER PT J AU HENDERSON, ME AF HENDERSON, ME TI DIVIDING MILITARY RETIREMENT PAY AND DISABILITY PAY - A MORE EQUITABLE APPROACH SO MILITARY LAW REVIEW LA English DT Article RP HENDERSON, ME (reprint author), USA,WASHINGTON,DC 20310, USA. NR 6 TC 2 Z9 2 U1 1 U2 1 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1991 VL 134 BP 87 EP 121 PG 35 WC Law SC Government & Law GA GX767 UT WOS:A1991GX76700003 ER PT J AU SMITH, JD AF SMITH, JD TI THE ADVOCATES USE OF SOCIAL-SCIENCE RESEARCH INTO NONVERBAL AND VERBAL COMMUNICATION - ZEALOUS ADVOCACY OR UNETHICAL CONDUCT SO MILITARY LAW REVIEW LA English DT Article ID SPEECH; LANGUAGE RP SMITH, JD (reprint author), USA,WASHINGTON,DC 20310, USA. NR 20 TC 3 Z9 3 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1991 VL 134 BP 173 EP 193 PG 21 WC Law SC Government & Law GA GX767 UT WOS:A1991GX76700006 ER PT J AU BORCH, FL AF BORCH, FL TI WITNESS FOR THE DEFENSE - LOFTUS,E, KETCHAM,K SO MILITARY LAW REVIEW LA English DT Book Review RP BORCH, FL (reprint author), USA,JUDGE ADVOCATE GEN SCH,DIV CRIMINAL LAW,WASHINGTON,DC 20310, USA. NR 1 TC 1 Z9 1 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1991 VL 134 BP 243 EP 245 PG 3 WC Law SC Government & Law GA GX767 UT WOS:A1991GX76700008 ER PT J AU BORCH, FL AF BORCH, FL TI AMERICA 1ST BLACK GENERAL - FLETCHER,ME SO MILITARY LAW REVIEW LA English DT Book Review RP BORCH, FL (reprint author), USA,JUDGE ADVOCATE GEN SCH,DIV CRIMINAL LAW,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1991 VL 134 BP 245 EP 248 PG 4 WC Law SC Government & Law GA GX767 UT WOS:A1991GX76700009 ER PT J AU EDWARDS, JSA ROBERTS, DE AF EDWARDS, JSA ROBERTS, DE TI THE INFLUENCE OF A CALORIE SUPPLEMENT ON THE CONSUMPTION OF THE MEAL, READY-TO-EAT IN A COLD ENVIRONMENT SO MILITARY MEDICINE LA English DT Article AB There is a dichotomy between calories issued to soldiers in their daily field rations and the amounts actually consumed. Soldiers frequently consume insufficient calories to maintain body weight. A supplemental pack (740 kcal) was developed, to increase field calorie consumption, and tested with the old and new versions of the Meal, Ready-to-Eat on a 10-day field study in Alaska. Initial and final measurements included body weights, heights, blood, and urine parameters. Daily measurements included the collection of urine samples and completion of a dietary intake log. Energy intakes of the supplemented groups were 4%-11% higher (p < 0.05) althoug the calorie intakes were still below the recommended 4,500 kcal/day for cold weather operations. Mean body weight loss ranged from 3.0 lb (1.7%) to 4.8 lb (2.8%). Two groups of the four groups became hypohydrated by day 3, due to low water intake, and only improved after direct intervention to increase drinking. Water and food intakes were strongly correlated (p < 0.05). Results confirm the success of the supplemental pack as a means of increasing food intake and underscore the importance of water discipline in a cold environment. RP EDWARDS, JSA (reprint author), USA,ENVIRONM MED RES INST,DIV MIL NUTR,NATICK,MA 01760, USA. NR 0 TC 6 Z9 6 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 1991 VL 156 IS 9 BP 466 EP 471 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA GF506 UT WOS:A1991GF50600011 PM 1961428 ER PT J AU HONDRUM, SO AF HONDRUM, SO TI THE UNITED-STATES-ARMY INSTITUTE OF DENTAL RESEARCH DENTAL MATERIALS SHELF-LIFE SURVEY - QUESTIONNAIRE RESULTS SO MILITARY MEDICINE LA English DT Article AB To define the nature and the extent of problems that can be related to the storage stability of perishable dental materials in the U.S. Army, questionnaires were sent to each U.S. Army Dental Corps Officer, supply NCO, and laboratory technician. Results reveal that two-thirds of dentists believe that the deterioration of perishable materials is a significant (28%) or occasional (39%) problem in their practice; the most common problem noted by dental clinicians is loss of efficacy of local anesthetics. One-half of clinicians and supply personnel report that they frequently receive perishable supplies at or near the expiration date. RP HONDRUM, SO (reprint author), WALTER REED ARMY MED CTR,INST DENT RES,DENT MAT BRANCH,WASHINGTON,DC 20307, USA. NR 0 TC 4 Z9 5 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 1991 VL 156 IS 9 BP 488 EP 491 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA GF506 UT WOS:A1991GF50600016 PM 1961432 ER PT J AU HONDRUM, SO AF HONDRUM, SO TI THE UNITED-STATES-ARMY INSTITUTE OF DENTAL RESEARCH DENTAL MATERIALS SHELF-LIFE SURVEY - LOT REQUEST RESULTS SO MILITARY MEDICINE LA English DT Article AB In an attempt to determine the age of perishable dental materials used at any one time in U.S. Army dental care facilities, a questionnaire was distributed to each U.S. Army Dental Activity supply point. Results reveal that almost half of commonly used perishable dental restorative materials are older than the expiration date, determined by the manufacturer's shelf-life, at the time of use. Materials used in OCONUS facilities are generally several months older than materials within CONUS facilities. Supply personnel could not determine the shelf-life of perishable restorative dental materials from package information in over 25% of all entries. RP HONDRUM, SO (reprint author), WALTER REED ARMY MED CTR,INST DENT RES,DENT MAT BRANCH,WASHINGTON,DC 20307, USA. NR 0 TC 4 Z9 4 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 1991 VL 156 IS 9 BP 491 EP 493 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA GF506 UT WOS:A1991GF50600017 PM 1961433 ER PT J AU ROSE, MS SZLYK, PC FRANCESCONI, RP LESTER, LS WHANG, R AF ROSE, MS SZLYK, PC FRANCESCONI, RP LESTER, LS WHANG, R TI ACCEPTABILITY AND EFFECT OF CARBOHYDRATE-ELECTROLYTE SOLUTIONS ON ELECTROLYTE HOMEOSTASIS DURING FIELD TRAINING SO MILITARY MEDICINE LA English DT Article AB Two lemon-lime flavored 2.5% carbohydrate-electrolyte solutions (CE1 supplemented with Na+, K+, and Mg+; and CE2 supplemented with NA+) were compared to plain water (water) and lemon-lime flavored water placebo (placebo) to evaluate their acceptability and consumption during 8 days of field training in hot weather. Acceptability ratings and consumption of CE2 and the flavored water placebo were similar and greater, respectively, than those for CE1. Average Na+ and K+ intakes, and serum electrolytes levels, were not affected during the 8-day trial. If food intake is adequate, consumption of carbohydrate-electrolyte solutions is apparently unnecessary to maintain electrolyte homeostasis. RP ROSE, MS (reprint author), USA,ENVIRONM MED RES INST,DIV HEAT RES,NATICK,MA 01760, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 1991 VL 156 IS 9 BP 494 EP 496 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA GF506 UT WOS:A1991GF50600018 PM 1961434 ER PT J AU SHIH, TM KOVIAK, TA CAPACIO, BR AF SHIH, TM KOVIAK, TA CAPACIO, BR TI ANTICONVULSANTS FOR POISONING BY THE ORGANOPHOSPHORUS COMPOUND SOMAN - PHARMACOLOGICAL MECHANISMS SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS LA English DT Review DE SOMAN; ORGANOPHOSPHORUS COMPOUNDS; TOXICITY; CONVULSIONS; SECRETION; LETHALITY; HI-6; ANTICONVULSANT; ANTIEPILEPTIC DRUGS; ANTICHOLINERGIC DRUGS; BENZODIAZEPINES; NMDA ANTAGONISTS; MK-801; BARBITURATES; CALCIUM CHANNEL BLOCKERS; ANTITUSSIVES; CARBAMATE CHOLINESTERASE INHIBITORS; ALPHA-2 ADRENERGIC AGONISTS; BRAIN DAMAGE; CHOLINERGIC RECEPTORS; EXCITATORY AMINO ACIDS; DRUG INTERACTIONS ID CHOLINESTERASE INHIBITOR SOMAN; MUSCARINIC RECEPTOR SUBTYPES; GAMMA-AMINOBUTYRIC ACID; REGIONAL GLUCOSE USE; RAT-BRAIN; INDUCED SEIZURES; INDUCED CONVULSIONS; NERVE AGENTS; KAINIC ACID; POTENT ANTICONVULSANT AB Exposure to high doses of organophosphorus nerve agents such as soman, even with carbamate pretreatment, produces a variety of toxic cholinergic signs, including secretions, convulsions and death. Evidence suggests that soman-induced convulsions may be associated with postexposure brain neuropathology, The purpose of this study was to investigate the pharmacologic mechanism of action of soman-induced convulsions and of anticonvulsant drugs. Various classes of compounds were evaluated for their efficacy in preventing soman-induced convulsions in rats pretreated with the oxime HI-6 to increase survival time, along with various doses of the test compounds (IM) either in the absence or presence of atropine sulfate (16 mg/kg, IM) 30 minutes prior to a soman challenge dose (180-mu-g/kg, SC: equivalent to 1.6 x LD50) that produced 100% convulsions. Without atropine sulfate, only tertiary anticholinergics (scopolamine, trihexyphenidyl, biperiden, benactyzine, benztropine, azaprophen and aprophen), caramiphen, carbetapentane and MK-801 were effective anticonvulsants. In the presence of atropine sulfate, the benzodiazepines (diazepam, midazolam, clonazepam, loprazolam and alprazolam), mecamylamine, flunarizine, diphenylhydantoin, clonidine, CGS 19755 and Organon 6370 studied were effective. We have examined the possibility that diazepam may exert some of its anticonvulsant effects through cholinergic mechanisms and found that a reduced release of ACh into synapses after diazepam and atropine treatment may account for diazepam's anticonvulsant activity against soman. We also found that at anticonvulsant doses biperiden and trihexyphenidyl each significantly reversed the effects of soman on striatal levels of DOPAC and HVA, the metabolites of dopamine, and have concluded that in addition to actions on muscarinic receptors, the anticonvulsant effects of these anticholinergics in soman poisoning may be partially related to their actions on the striatal dopaminergic system. These findings allow us to postulate that central muscarinic cholinergic mechanisms are primarily involved in eliciting the convulsions following exposure to soman and that subsequent recruitment of other excitatory neurotransmitter systems and loss of inhibitory control may be responsible for sustaining the convulsions and for producing the subsequent brain damage. Future studies to confirm these neuropharmacological mechanisms are proposed. RP SHIH, TM (reprint author), USA,DIV PHARMACOL,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 158 TC 143 Z9 146 U1 0 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0149-7634 J9 NEUROSCI BIOBEHAV R JI Neurosci. Biobehav. Rev. PD FAL PY 1991 VL 15 IS 3 BP 349 EP 362 PG 14 WC Behavioral Sciences; Neurosciences SC Behavioral Sciences; Neurosciences & Neurology GA FX228 UT WOS:A1991FX22800005 PM 1683477 ER PT J AU SCHOMER, P AF SCHOMER, P TI A 5-POINT PROGRAM FOR THE NEW OFFICE OF NOISE ABATEMENT AND CONTROL SO NOISE CONTROL ENGINEERING JOURNAL LA English DT Editorial Material RP SCHOMER, P (reprint author), USA,CERL,WASHINGTON,DC 20310, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INST NOISE CONTROL ENG PI POUGHKEEPSIE PA PO BOX 3206 ARLINGTON BRANCH, POUGHKEEPSIE, NY 12603 SN 0736-2501 J9 NOISE CONTROL ENG JI Noise Control Eng. J. PD SEP-OCT PY 1991 VL 37 IS 2 BP 51 EP 51 PG 1 WC Acoustics; Engineering, Multidisciplinary SC Acoustics; Engineering GA GU195 UT WOS:A1991GU19500001 ER PT J AU XIE, JG RUEKGAUER, TE GU, J ARMSTRONG, RL PINNICK, RG AF XIE, JG RUEKGAUER, TE GU, J ARMSTRONG, RL PINNICK, RG TI OBSERVATIONS OF DESCARTES RING STIMULATED RAMAN-SCATTERING IN MICROMETER-SIZED WATER DROPLETS SO OPTICS LETTERS LA English DT Article ID MORPHOLOGY-DEPENDENT RESONANCES; RADIATION PRESSURE; OPTICAL LEVITATION; LASER-EMISSION AB Stimulated Raman scattering (SRS) from micrometer-sized droplets, which results from coupling of spontaneous Raman emission to droplet morphology-dependent resonances (MDR's), exhibits unique characteristics. Spatial patterns consist of bright SRS arcs on the droplet rim. A second source of SRS emission has recently been observed from a ringlike region encircling the droplet axis near the geometric focus (the Descartes ring). Investigation of the time and spectral characteristics of Descartes ring SRS and its suppression by the addition of absorptive dye to the droplet reveals it to be an additional manifestation of droplet MDR's. We conjecture that the Descartes ring results when the MDR light is scattered by refractive-index inhomogeneities produced by the intense pump field within the droplet. C1 ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002. RP XIE, JG (reprint author), NEW MEXICO STATE UNIV,DEPT PHYS,LAS CRUCES,NM 88003, USA. NR 18 TC 20 Z9 20 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD SEP 1 PY 1991 VL 16 IS 17 BP 1310 EP 1312 DI 10.1364/OL.16.001310 PG 3 WC Optics SC Optics GA GE692 UT WOS:A1991GE69200006 PM 19776954 ER PT J AU SOULIERE, CR KAVA, CR BARRS, DM BELL, AF AF SOULIERE, CR KAVA, CR BARRS, DM BELL, AF TI SUDDEN HEARING-LOSS AS THE SOLE MANIFESTATION OF NEUROSARCOIDOSIS SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article ID SARCOIDOSIS AB Sarcoidosis is a chronic, idiopathic granulomatous disease with frequent pulmonary, ocular, and lymphatic systemic manifestations. Central nervous system involvement is rare (1% to 5%), yet the most frequent presenting symptoms (48%) in patients with neurosarcoidosis are neurologic. Eighth cranial nerve abnormalities occur in 20% of these patients, typically in association with other cranial neuropathies or overt systemic disease. Isolated eighth nerve disease is very rare. We report two cases of neurosarcoidosis manifest as isolated, sudden onset sensorineural hearing loss, one of which had a cerebellopontine angle (CPA) granuloma that mimicked an acoustic neuroma. Both patients experienced marked steroid-induced hearing improvement that persisted after termination of therapy. Brainstem evoked response audiometry (BSER) abnormality persisted despite normalization of audiologic parameters. The implications for diagnosis and treatment of sarcoidosis-induced hearing loss are described. Neurosarcoidosis must be considered when evaluating patients with sudden hearing loss. Prompt steroid therapy offers hope for significant hearing recovery in these patients. C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. OTOL ASSOCIATES,SAN ANTONIO,TX. WEISBADEN USAF HOSP,WIESBADEN,GERMANY. NR 11 TC 22 Z9 22 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD SEP PY 1991 VL 105 IS 3 BP 376 EP 381 PG 6 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA GF555 UT WOS:A1991GF55500005 PM 1945422 ER PT J AU HAYES, DK MADSEN, JM SIMPSON, R JARCHOW, RC AF HAYES, DK MADSEN, JM SIMPSON, R JARCHOW, RC TI MYXOMAS OF THE MAXILLA IN INFANTS AND CHILDREN SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. NR 21 TC 4 Z9 4 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD SEP PY 1991 VL 105 IS 3 BP 464 EP 468 PG 5 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA GF555 UT WOS:A1991GF55500019 PM 1945436 ER PT J AU BRIEN, JH AF BRIEN, JH TI A PEDIATRICIAN IN THE PERSIAN-GULF-WAR - A CAREER OFFICERS VIEW SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE MILITARY PEDIATRICS; PERSIAN-GULF-WAR RP BRIEN, JH (reprint author), BROOKE ARMY MED CTR,DEPT PEDIAT,INFECT DIS SECT,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 5 Z9 5 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD SEP PY 1991 VL 10 IS 9 BP 643 EP 645 DI 10.1097/00006454-199109000-00003 PG 3 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA GE934 UT WOS:A1991GE93400002 PM 1923674 ER PT J AU LEEK, MR BROWN, ME DORMAN, MF AF LEEK, MR BROWN, ME DORMAN, MF TI INFORMATIONAL MASKING AND AUDITORY ATTENTION SO PERCEPTION & PSYCHOPHYSICS LA English DT Article ID FREQUENCY DISCRIMINATION; LOUDNESS ENHANCEMENT; SELECTIVE ATTENTION; TONAL PATTERNS; COMPONENTS; HEARING AB Informational masking is broadly defined as a degradation of auditory detection or discrimination of a signal embedded in a context of other similar sounds; it is not related to energetic masking caused by physical interactions between signal and masker. In this paper, we report a systematic release from informational masking of a target tone in a nine-tone rapid auditory sequence as the target is increasingly isolated in frequency or intensity from the remaining sequence components. Improved target-tone frequency difference limens as isolation increases are interpreted as a reflection of increasingly focused auditory attention. The change from diffuse to highly focused attention is gradual over the frequency and intensity ranges examined, with each 1-dB increment in target intensity relative to the remaining components producing performance improvements equivalent to those produced by a 2% increase in frequency isolation. The results are modeled as bands of attention in the frequency and intensity domains. For attention directed by frequency isolation, there is a strong correspondence with auditory filters predicted by the power spectrum model of masking. These data also support the existence of an attention band of intensity, with a bandwidth of about 5-7 dB at the moderate levels used in this experiment. C1 ARIZONA STATE UNIV,TEMPE,AZ 85287. RP LEEK, MR (reprint author), WALTER REED ARMY MED CTR,CTR ARMY AUDIOL & SPEECH,WASHINGTON,DC 20307, USA. NR 33 TC 48 Z9 49 U1 1 U2 7 PU PSYCHONOMIC SOC INC PI AUSTIN PA 1710 FORTVIEW RD, AUSTIN, TX 78704 SN 0031-5117 J9 PERCEPT PSYCHOPHYS JI Percept. Psychophys. PD SEP PY 1991 VL 50 IS 3 BP 205 EP 214 DI 10.3758/BF03206743 PG 10 WC Psychology; Psychology, Experimental SC Psychology GA GE672 UT WOS:A1991GE67200002 PM 1754361 ER PT J AU SCHLAGER, JW DOLZINE, TW STEWART, JR WANNARKA, GL SHIH, ML AF SCHLAGER, JW DOLZINE, TW STEWART, JR WANNARKA, GL SHIH, ML TI OPERATIONAL EVALUATION OF 3 COMMERCIAL CONFIGURATIONS OF ATROPINE/HI-6 WET DRY AUTOINJECTORS SO PHARMACEUTICAL RESEARCH LA English DT Article DE AUTOINJECTOR; WET DRY; HI-6; ATROPINE ID SOMAN; HI-6; SARIN; HGG-12; OXIMES; MICE AB Commercially manufactured wet/dry autoinjectors containing atropine in solution and powdered HI-6 were evaluated using HPLC for consistency of drug delivery with various solvation times and stability of drugs postsolvation at a temperature of 40-degrees-C. Three configurations of autoinjector were tested. System A (SYS A), with a specified mixing time of 5 sec, delivered a volume of 3.0 ml containing 1.86 mg of atropine sulfate and 443 mg of the bispyridinium oxime HI-6 dichloride. System B1 (SYS B1) and System B2 (SYS B2), with specified mixing times of 40 sec, delivered volumes of 2.3 ml containing 2.13 and 2.06 mg atropine citrate and 424 and 545 mg HI-6 dichloride, respectively. Average coefficients of variation for SYS A were 3.4% for atropine and 5.8% for HI-6 and for SYS B1 and B2 were 5.2% for atropine and 7.0% for HI-6 determinations. Stored from 3 to 14 days at 40-degrees-C after the autoinjector contents were mixed, SYS A delivered 1.77 mg atropine sulfate and SYS B1 and B2 delivered 2.02 mg atropine citrate. The delivery of HI-6 dichloride decreased with a half-life of 34 days for SYS A, 39 days for SYS B1, and 32 days for SYS B2. This resulted in a decrease to 90% of the respective day 0 amount after 4 (SYS A) or 5 (SYS B1 or B2) days. C1 HLTH CARE STUDIES & CLIN INVESTIGAT,DIV CLIN INVEST PROGRAM,FT SAM HOUSTON,TX 78234. USA,MED RES INST CHEM DEF,DIV DRUG ASSESSMENT,ABERDEEN PROVING GROUND,MD 21010. RP SCHLAGER, JW (reprint author), USA,MED RES INST CHEM DEF,ANALYT CHEM BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 15 TC 10 Z9 10 U1 0 U2 2 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0724-8741 J9 PHARMACEUT RES JI Pharm. Res. PD SEP PY 1991 VL 8 IS 9 BP 1191 EP 1194 DI 10.1023/A:1015818821686 PG 4 WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy SC Chemistry; Pharmacology & Pharmacy GA GD324 UT WOS:A1991GD32400017 PM 1788166 ER PT J AU SCHLEICH, WP DOWLING, JP HOROWICZ, RJ AF SCHLEICH, WP DOWLING, JP HOROWICZ, RJ TI EXPONENTIAL DECREASE IN PHASE UNCERTAINTY SO PHYSICAL REVIEW A LA English DT Note AB The phase probability curve of a recently proposed photon state consists of a broad background with a sharp central peak [J. H. Shapiro, S. R. Shepard, and N. Wong, Phys. Rev. Lett. 62, 2377 (1989)]. These authors argue that the inverse peak-height phase uncertainty delta-phi of this distribution decreases inversely as the square of the mean photon number -an improvement over either coherent or highly squeezed states. We show that the width DELTA-phi of the best-fitting Gaussian to the central peak-a measure of phase uncertainty tailored to this narrow feature-decreases exponentially with increasing . The importance of this result may be offset by the observation that the area under this peak also vanishes very rapidly. C1 USA, MISSILE COMMAND, AMSMI RD WS, WEAP SCI DIRECTORATE, REDSTONE ARSENAL, AL 35898 USA. NIPPON TELEGRAPH & TEL PUBL CORP, MUSASHINO ELECT COMMUN LAB, BASIC RES LABS, MUSASHINO, TOKYO 180, JAPAN. UNIV ULM, THEORET PHYS ABT 3, W-7900 ULM, GERMANY. PONTIFICIA UNIV CATOLICA RIO DE JANEIRO, DEPT PHYS, BR-22453 RIO DE JANEIRO, RJ, BRAZIL. RP SCHLEICH, WP (reprint author), MAX PLANCK INST QUANTUM OPT, W-8046 GARCHING, GERMANY. RI DOWLING, JONATHAN/L-2749-2013 NR 15 TC 27 Z9 27 U1 0 U2 0 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 EI 1094-1622 J9 PHYS REV A JI Phys. Rev. A PD SEP 1 PY 1991 VL 44 IS 5 BP 3365 EP 3368 DI 10.1103/PhysRevA.44.3365 PG 4 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA GE936 UT WOS:A1991GE93600076 ER PT J AU MALEVSKY, AV YUEN, DA AF MALEVSKY, AV YUEN, DA TI CHARACTERISTICS-BASED METHODS APPLIED TO INFINITE PRANDTL NUMBER THERMAL-CONVECTION IN THE HARD TURBULENT REGIME SO PHYSICS OF FLUIDS A-FLUID DYNAMICS LA English DT Article ID FLUX-CORRECTED TRANSPORT; NAVIER-STOKES EQUATIONS; MANTLE CONVECTION; SIMULATIONS; ALGORITHMS; FLOWS AB The use of characteristics-based methods for the advection-dominated regimes in thermal convection is investigated. An operator-splitting method applied to the advection-diffusion equation for the very large Peclet (Pe) number regime is presented. In this approach two partial differential equations representing both the purely hyperbolic and the parabolic components must be solved simultaneously. This method has been compared with (1) the Galerkin approximation, (2) the streamwise upwinding Petrov-Galerkin method, and (3) the characteristics-based method using the Lagrangian formulation for the time-derivative operator of the advection-diffusion equation. Solution accuracy of the operator-splitting method improves with larger Pe, while the accuracy of other methods deteriorates with Pe. For the nonlinear problem of two-dimensional thermal convection the Lagrangian method is found to be most computationally efficient. With this Lagrangian method, time-dependent, thermal convection solutions of extremely high Rayleigh number (Ra), up to 3 X 10(9), for infinite Prandtl number are obtained. For an aspect ratio of 1.8 the exponent in the scaling of the Nusselt number (Nu) with Ra in time-dependent convection is determined to be 0.301 in the hard turbulent regime and is smaller than in the soft turbulent regime. The behavior of this exponent as a consequence of the transition to hard turbulence agrees with experimental findings. Horizontal Fourier spectra of the thermal fields outside the boundary layers reveal a transition in the high wave-number domain from 1/k to 1/k2 in the transition from soft to hard turbulent regimes. Analysis of the kinetic energy spectra E(k) shows an asymptotic decay of E(k) close to K-2, for large k, spanning over two decades in wave number for strongly time-dependent convection. RP MALEVSKY, AV (reprint author), UNIV MINNESOTA,MINNESOTA SUPERCOMP INST,ARMY HIGH PERFORMANCE COMP & RES CTR,MINNEAPOLIS,MN 55455, USA. NR 36 TC 31 Z9 35 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0899-8213 J9 PHYS FLUIDS A-FLUID PD SEP PY 1991 VL 3 IS 9 BP 2105 EP 2115 DI 10.1063/1.857893 PG 11 WC Mechanics; Physics, Fluids & Plasmas SC Mechanics; Physics GA GD545 UT WOS:A1991GD54500011 ER PT J AU EICKEN, H ACKLEY, SF RICHTERMENGE, JA LANGE, MA AF EICKEN, H ACKLEY, SF RICHTERMENGE, JA LANGE, MA TI IS THE STRENGTH OF SEA ICE RELATED TO ITS CHLOROPHYLL CONTENT SO POLAR BIOLOGY LA English DT Note AB Results of uniaxial compression test are compared to porosity and chlorophyll content of granular sea-ice samples, collected in the Weddell Sea from June to November of 1986. Compressive failure stresses are significantly correlated with the total porosity of the ice, but exhibit no correlation with chlorophyll concentration. We suggest that high chlorophyll concentrations may accompany low ice strengths only because high porosities, which are responsible for low mechanical strength, can be linked to sea-ice biology. High concentrations of ice algae may be either cause or effect of high porosities (through absorption of solar radiation in the first case or due to enhanced nutrient supply and environmental space in the second case). As a cause of high porosities, ice organisms could therefore indirectly influence the spring breakup of floes and thus the course of the ablation season. C1 COLD REG RES & ENGN LAB,HANOVER,NH 03755. RP EICKEN, H (reprint author), ALFRED WEGENER INST POLAR & MARINE RES,COLUMBUSSTR,W-2850 BREMERHAVEN,GERMANY. RI Eicken, Hajo/M-6901-2016 NR 18 TC 9 Z9 9 U1 0 U2 3 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0722-4060 J9 POLAR BIOL JI Polar Biol. PD SEP PY 1991 VL 11 IS 5 BP 347 EP 350 PG 4 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA GG912 UT WOS:A1991GG91200008 ER PT J AU OHEARN, CJ AF OHEARN, CJ TI PHYSICIAN ASSISTANTS ROLE IN COMBAT MEDICINE SO POSTGRADUATE MEDICINE LA English DT Letter RP OHEARN, CJ (reprint author), USA,MED CORPS,SAN ANTONIO,TX, USA. NR 1 TC 1 Z9 1 U1 0 U2 0 PU MCGRAW HILL HEALTHCARE PUBLICATIONS PI MINNEAPOLIS PA 4530 WEST 77TH ST, MINNEAPOLIS, MN 55435-5000 SN 0032-5481 J9 POSTGRAD MED JI Postgrad. Med. PD SEP 1 PY 1991 VL 90 IS 3 BP 48 EP 48 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA GE040 UT WOS:A1991GE04000006 PM 1679233 ER PT J AU LIU, CT GUO, ZM AF LIU, CT GUO, ZM TI TECHNIQUE FOR REPEATED COLLECTION OF CEREBROSPINAL-FLUID FROM CISTERNA MAGNA OF ANESTHETIZED STRAIN-13 GUINEA-PIGS SO PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE LA English DT Article ID PHASE AB To study biochemical changes in cerebrospinal fluid (CSF), we developed a reliable technique for repeated collection of CSF in anesthetized strain 13 guinea pigs. The animal's head was mounted in a stereotaxic instrument with ventral tilt at 30-degrees, and cisternal puncture was made with an L-shaped, 23-gauge needle through the shaved skin. Clear CSF was collected in a 1-ml syringe surrounded by crushed ice. Each collection procedure lasted for 3 min, and three consecutive collections produced about 0.2 ml of CSF. Sampling was repeated at 3-hr intervals. With intravenous saline infusion (10 ml/kg.hr), a total volume of 0.6-1.0 ml of CSF was collected over 6 to 12 hr. Animals maintained a mean blood pressure, heart rate, and minute volume, with few changes during CSF sampling for the entire collection. RP LIU, CT (reprint author), USA,MED RES INST INFECT DIS,DEPT CLIN & EXPTL PHYSIOL,DIV DIS ASSESSMENT,FT DETRICK,FREDERICK,MD 21702, USA. NR 8 TC 7 Z9 7 U1 0 U2 0 PU BLACKWELL SCIENCE INC PI CAMBRIDGE PA 238 MAIN ST, CAMBRIDGE, MA 02142 SN 0037-9727 J9 P SOC EXP BIOL MED JI Proc. Soc. Exp. Biol. Med. PD SEP PY 1991 VL 197 IS 4 BP 400 EP 403 PG 4 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA GD338 UT WOS:A1991GD33800008 PM 1871150 ER PT J AU ROSEN, LN ROSENTHAL, NE AF ROSEN, LN ROSENTHAL, NE TI SEASONAL-VARIATIONS IN MOOD AND BEHAVIOR IN THE GENERAL-POPULATION - A FACTOR-ANALYTIC APPROACH SO PSYCHIATRY RESEARCH LA English DT Article DE DEPRESSION; HYPERSOMNIA; WEIGHT CHANGE; SOCIABILITY ID AFFECTIVE-DISORDER AB In a mailed survey conducted at four centers-Nashua, NH; New York, NY; Washington, DC; and Sarasota, FL-1,671 respondents provided information on monthly variations in 10 behavioral categories representing extremes in the areas of mood, socializing, appetite, weight gain/loss, and sleep length. A 10-factor solution revealed the following factors: (1) a winter weight gain factor; (2) a winter depression factor; (3) a winter hypersomnia factor; (4) a summer weight gain factor; (5) a summer hypersomnia factor; (6) a summer depression factor; (7) a winter socializing factor; (8) a winter weight loss factor; (9) a fall depression factor; and (10) a possibly mixed factor. Factors consistent with winter seasonal affective disorder were positively correlated with latitude, while those consistent with summer seasonal affective disorder were negatively correlated with latitude. C1 NIMH,CLIN PSYCHOBIOL BRANCH,OUTPATIENT STUDIES UNIT,BLDG 10 4S-239,9000 ROCKVILLE PIKE,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,DEPT MIL PSYCHIAT,WASHINGTON,DC 20307. NR 13 TC 26 Z9 26 U1 1 U2 3 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0165-1781 J9 PSYCHIAT RES JI Psychiatry Res. PD SEP PY 1991 VL 38 IS 3 BP 271 EP 283 DI 10.1016/0165-1781(91)90017-J PG 13 WC Psychiatry SC Psychiatry GA GM625 UT WOS:A1991GM62500006 PM 1754639 ER PT J AU MONGAN, PD STRONG, WE MENK, EJ AF MONGAN, PD STRONG, WE MENK, EJ TI ANESTHESIA FOR PERCUTANEOUS RENAL PROCEDURES SO REGIONAL ANESTHESIA LA English DT Article DE ANESTHESIA, REGIONAL, LUMBAR SYMPATHETIC BLOCK, KIDNEY, PERCUTANEOUS RENAL AB Anesthesia for radiologic procedures is usually provided in locations remote from the operating theater. The anesthesiologist is removed from the environment in which experienced support is available for the care of anesthetized patients. Therefore, reliable anesthetic techniques that cause the least perturbation in the patient's physiology are often preferred. This is a report of the application of a paravertebral and lumbar sympathetic block to provide anesthesia for the renal pelvis and ureter so that percutaneous radiologic procedures that involve the manipulation and dilation of those areas can be performed with minimal patient discomfort. RP MONGAN, PD (reprint author), BROOKE ARMY MED CTR,DEPT SURG,ANESTHESIA & OPERAT SERV,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS PI NEW YORK PA 650 AVENUE OF THE AMERICAS, NEW YORK, NY 10011 SN 0146-521X J9 REGION ANESTH JI Reg. Anesth. PD SEP-OCT PY 1991 VL 16 IS 5 BP 296 EP 298 PG 3 WC Anesthesiology SC Anesthesiology GA GK865 UT WOS:A1991GK86500014 PM 1958612 ER PT J AU NACY, CA NELSON, BJ MELTZER, MS GREEN, SJ AF NACY, CA NELSON, BJ MELTZER, MS GREEN, SJ TI CYTOKINES THAT REGULATE MACROPHAGE PRODUCTION OF NITROGEN-OXIDES AND EXPRESSION OF ANTILEISHMANIAL ACTIVITIES SO RESEARCH IN IMMUNOLOGY LA English DT Article ID MOUSE PERITONEAL-MACROPHAGES; LEISHMANIA-TROPICA; L-ARGININE; INTRACELLULAR REPLICATION; MURINE MACROPHAGES; INTERFERON-GAMMA; AMASTIGOTES; DESTRUCTION; ACTIVATION; INDUCTION RP NACY, CA (reprint author), WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,9620 MED CTR DR,ROCKVILLE,MD 20850, USA. NR 21 TC 15 Z9 15 U1 0 U2 0 PU EDITIONS SCIENTIFIQUES ELSEVIER PI PARIS CEDEX 15 PA 141 RUE JAVEL, 75747 PARIS CEDEX 15, FRANCE SN 0923-2494 J9 RES IMMUNOL JI Res. Immunol. PD SEP PY 1991 VL 142 IS 7 BP 573 EP 576 DI 10.1016/0923-2494(91)90105-R PG 4 WC Immunology SC Immunology GA GU256 UT WOS:A1991GU25600010 PM 1812551 ER PT J AU GABEL, CR AF GABEL, CR TI THE GREAT CRUSADE - A NEW COMPLETE HISTORY OF WORLD-WAR-II - WILLMOTT,HP SO REVIEWS IN AMERICAN HISTORY LA English DT Book Review RP GABEL, CR (reprint author), USA COMMAND & GEN STAFF COLL,INST COMBAT STUDIES,FT LEAVENWORTH,KS 66027, USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU JOHNS HOPKINS UNIV PRESS PI BALTIMORE PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD 21218-4319 SN 0048-7511 J9 REV AM HIST JI Rev. Am. Hist. PD SEP PY 1991 VL 19 IS 3 BP 414 EP 418 DI 10.2307/2703189 PG 5 WC History SC History GA GF340 UT WOS:A1991GF34000019 ER PT J AU COSGRIFF, TM LEE, HW SEE, AF PARRISH, DB MOON, JS KIM, DJ LEWIS, RM AF COSGRIFF, TM LEE, HW SEE, AF PARRISH, DB MOON, JS KIM, DJ LEWIS, RM TI PLATELET DYSFUNCTION CONTRIBUTES TO THE HEMOSTATIC DEFECT IN HEMORRHAGIC-FEVER WITH RENAL SYNDROME SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID HEMORRHAGIC-FEVER AB To characterize further the nature of haemostatic impairment in haemorrhagic fever with renal syndrome, we assessed platelet function in 9 patients in whom the diagnosis was serologically confirmed. Defective platelet aggregation was demonstrated in every patient. An abnormality of the granule release reaction was demonstrated in all of 7 patients tested. Gel-filtered platelets from a normal subject showed normal aggregation in plasma from a patient with impaired aggregation, which is evidence for an intrinsic platelet defect, and against the presence of a circulating inhibitor in this patient. C1 CAPITAL ARMY HOSP,SEOUL,SOUTH KOREA. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. UNIV KOREA,INST VIRAL DIS,SEOUL,SOUTH KOREA. NR 18 TC 18 Z9 18 U1 0 U2 1 PU ROYAL SOC TROPICAL MEDICINE PI LONDON PA MANSON HOUSE 26 PORTLAND PLACE, LONDON, ENGLAND W1N 4EY SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD SEP-OCT PY 1991 VL 85 IS 5 BP 660 EP 663 DI 10.1016/0035-9203(91)90386-D PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA GM446 UT WOS:A1991GM44600032 PM 1685813 ER PT J AU MING, ZF XI, ZD DONG, CS SERICHANTALERGS, O CHANGCHAWALIT, S NIRDNOY, W QIONG, L ECHEVERRIA, P AF MING, ZF XI, ZD DONG, CS SERICHANTALERGS, O CHANGCHAWALIT, S NIRDNOY, W QIONG, L ECHEVERRIA, P TI DIARRHEAL DISEASE IN CHILDREN LESS THAN ONE YEAR OF AGE AT A CHILDRENS HOSPITAL IN GUANGZHOU, PEOPLES-REPUBLIC-OF-CHINA SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID ENTEROPATHOGENIC ESCHERICHIA-COLI; DIARRHEAL DISEASE; DNA HYBRIDIZATION; SURVEILLANCE; ADHERENCE; THAILAND; SHIGELLA; PROBE; CELLS AB We performed a case-control study of diarrhoea to determine its causes in children < 1 year old in Guangzhou, People's Republic of China, in April to September 1989. Stools were cultured for Salmonella, Shigella, Campylobacter and vibrios by standard techniques; rotavirus (RV) was identified by polyacrylamide gel electrophoresis; and specific deoxyribonucleic acid probes were used to identify Escherichia coli containing genes coding for Shiga-like toxin I and II, enteropathogenic E. coli adherence factor, and enteroinvasive E. coli (EIEC). E. coli isolates were tested for heat-labile toxin (LT) and heat-stable toxin (ST) production and mannose-resistant adherence to HeLa cells. Rotavirus was identified in 13 of 174 children with diarrhoea (cases) and in 2% of 174 age-matched children without diarrhoea (controls), P < 0.001. C. jejuni was identified in 10% of cases and 2% of controls, P = 0.003. Giardia lamblia was identified in 4 cases, LT and ST enterotoxigenic E. coli (ETEC) in 2, and S. flexneri in 1 case; they were not found in controls. ETEC that produced LT only was isolated from 5 cases and 3 controls, P = 0.721; E. coli that adhered to HeLa cells in a diffuse pattern was isolated from 30 cases and 40 controls, P = 0.229; and E. coli that adhered in an aggregative pattern was isolated from 20 cases and 18 controls, P = 0.863. EIEC was not isolated from cases or controls. Nine cases (5%) developed persistent diarrhoea (> 14 d duration). C. jejuni and aggregative E. coli were isolated from different children with persistent diarrhoea. E. coli (serogroup 0119), adherence factor positive, which adhered to HeLa cells in a localized pattern, was isolated from 1 control. Rotavirus and C. jejuni were the most common) causes of diarrhoea in children < 1 year of age in Guangzhou in the summer of 1989. C1 ARMED FORCES RES INST MED SCI,RAJVITHI RD,BANGKOK 10400,THAILAND. GUANGDONG MED & PHARMACEUT COLL,GUANGZHOU,PEOPLES R CHINA. NR 22 TC 13 Z9 13 U1 0 U2 0 PU ROYAL SOC TROPICAL MEDICINE PI LONDON PA MANSON HOUSE 26 PORTLAND PLACE, LONDON, ENGLAND W1N 4EY SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD SEP-OCT PY 1991 VL 85 IS 5 BP 667 EP 669 DI 10.1016/0035-9203(91)90389-G PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA GM446 UT WOS:A1991GM44600034 PM 1781004 ER PT J AU JACKSON, AC SENGUPTA, SK SMITH, JF AF JACKSON, AC SENGUPTA, SK SMITH, JF TI PATHOGENESIS OF VENEZUELAN EQUINE ENCEPHALITIS-VIRUS INFECTION IN MICE AND HAMSTERS SO VETERINARY PATHOLOGY LA English DT Article DE ARBOVIRUS; ENCEPHALITIS; ENCEPHALOMYELITIS; IMMUNOHISTOCHEMISTRY; PATHOGENESIS; VENEZUELAN EQUINE ENCEPHALITIS VIRUS ID CELL-CULTURE; IMMUNOPEROXIDASE TECHNIQUES; ENCEPHALOMYELITIS VIRUS; INSULIN RELEASE; NEONATAL MICE; NEUROVIRULENCE; PENETRATION; INVOLVEMENT; METABOLISM; VIRULENCE AB The pathogenesis of Venezuelan equine encephalitis (VEE) virus infection was compared in intraperitoneally inoculated mice (n = 24, 6 to 8 weeks old) and hamsters (n = 9, 90-110 g) using histopathology and immunohistochemical localization of VEE virus antigen. Infected mice developed paralysis, and the majority died by 9 days after inoculation. In contrast, hamsters did not survive beyond 3 days after inoculation, and they did not develop any neurologic signs. VEE virus antigen, demonstrated by immunoperoxidase staining, and pathologic changes were present in extraneural organs of both mice and hamsters. There was more severe involvement in hamsters, particularly in Peyer's patches of the distal small intestine. There was a severe encephalomyelitis in mice, but pathologic changes were not well established in the brains of hamsters before death. VEE virus antigen was widespread in the central nervous system of both mice and hamsters. VEE virus was found to be highly neurotropic in hamsters and had a similar distribution in the brain as in mice, but hamsters died from their extraneural disease before major central nervous system disease developed. C1 QUEENS UNIV,DEPT MICROBIOL & IMMUNOL,KINGSTON K7L 3J7,ONTARIO,CANADA. QUEENS UNIV,DEPT PATHOL,KINGSTON L7L 3J7,ONTARIO,CANADA. USA,MED RES INST INFECT DIS,DIV VIROL,FREDERICK,MD 21701. RP JACKSON, AC (reprint author), QUEENS UNIV,DEPT MED,78 BARRIE ST,KINGSTON K7L 3J7,ONTARIO,CANADA. OI Jackson, Alan/0000-0003-0413-4236 NR 48 TC 51 Z9 53 U1 0 U2 1 PU AMER COLL VET PATHOLOGIST PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 SN 0300-9858 J9 VET PATHOL JI Vet. Pathol. PD SEP PY 1991 VL 28 IS 5 BP 410 EP 418 PG 9 WC Pathology; Veterinary Sciences SC Pathology; Veterinary Sciences GA GJ552 UT WOS:A1991GJ55200009 PM 1750167 ER PT J AU STROSCIO, MA IAFRATE, GJ KIM, KW LITTLEJOHN, MA GORONKIN, H MARACAS, GN AF STROSCIO, MA IAFRATE, GJ KIM, KW LITTLEJOHN, MA GORONKIN, H MARACAS, GN TI TRANSITION FROM LONGITUDINAL-OPTICAL PHONON-SCATTERING TO SURFACE-OPTICAL PHONON-SCATTERING IN POLAR SEMICONDUCTOR SUPERLATTICES SO APPLIED PHYSICS LETTERS LA English DT Article ID RECTANGULAR QUANTUM WIRE; ELECTRONIC POLARIZABILITY; DOUBLE HETEROSTRUCTURES; FROHLICH INTERACTION; MODES AB Dielectric continuum models of optical-phonon modes predict an enhancement in the strength of the surface-optical (SO) modes in double-barrier heterostructures as the heterojunction-to-heterojunction separation is reduced. There is currently no consensus on the nature of the electron-SO-phonon coupling interaction. In this work, the ratio of electron scattering by the SO-phonon modes to that by the confined longitudinal-optical (LO) phonon modes is calculated for a GaAs/AlAs short-period superlattice based on the assumption that the electron-SO-phonon interaction may be described by a scalar potential. The scaling of the ratio of electron-SO-phonon scattering to electron-LO-phonon scattering as a function of the superlattice period provides a sensitive test of the appropriateness of the scalar-potential model. C1 N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695. MOTOROLA PHOENIX CORP,RES LAB,TEMPE,AZ 85284. ARIZONA STATE UNIV,DEPT ELECT ENGN,TEMPE,AZ 85281. RP STROSCIO, MA (reprint author), USA,RES OFF,RES TRIANGLE PK,NC 27709, USA. NR 20 TC 36 Z9 36 U1 1 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD AUG 26 PY 1991 VL 59 IS 9 BP 1093 EP 1095 DI 10.1063/1.106354 PG 3 WC Physics, Applied SC Physics GA GC329 UT WOS:A1991GC32900031 ER PT J AU WAKELEY, LD WONG, GS AF WAKELEY, LD WONG, GS TI PETROGRAPHIC TECHNIQUES APPLIED TO CEMENT-SOLIDIFIED HAZARDOUS-WASTE SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,ENGINEER WATERWAYS EXPT STN,DIV CONCRETE TECHNOL,VICKSBURG,MS 39180. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 25 PY 1991 VL 202 BP 9 EP ENVR PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HG080 UT WOS:A1991HG08001683 ER PT J AU MYERS, SA BODALBHAI, L BRAJTERTOTH, A MACKAY, RA AF MYERS, SA BODALBHAI, L BRAJTERTOTH, A MACKAY, RA TI ELECTROCHEMICAL INSIGHTS INTO MICROEMULSION MICROSTRUCTURE AND ITS EFFECT ON ELECTRON-TRANSFER SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 UNIV FLORIDA,DEPT CHEM,GAINESVILLE,FL 32611. USA,CRDEC,ABERDEEN PROVING GROUND,MD 21010. RI brajter-toth, anna/E-8777-2016 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 25 PY 1991 VL 202 BP 23 EP COLL PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HG080 UT WOS:A1991HG08001422 ER PT J AU CANNON, PL GARLICK, SM WONG, NM NOVELLI, AC MACKAY, RA LONGO, FR AF CANNON, PL GARLICK, SM WONG, NM NOVELLI, AC MACKAY, RA LONGO, FR TI ELECTROCHEMICAL PROCESSES IN THE SINGLE-PHASE REGIONS OF SDS/1-PENTANOL CYCLOHEXANE WATER MICROEMULSIONS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CRDEC,ABERDEEN PROVING GROUND,MD 21010. GEOCENTERS INC,FT WASHINGTON,MD 20744. DREXEL UNIV,PHILADELPHIA,PA 19104. UNIV TOULOUSE 3,LAB IMRCP,F-31062 TOULOUSE,FRANCE. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 25 PY 1991 VL 202 BP 24 EP COLL PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HG080 UT WOS:A1991HG08001423 ER PT J AU LAWHORNE, S FAMINI, G COON, P AF LAWHORNE, S FAMINI, G COON, P TI CHEMICAL DATABASE-MANAGEMENT AT THE US-ARMY-CHEMICAL-RESEARCH-DEVELOPMENT-AND-ENGINEERING-CENTER SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CHEM RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 25 PY 1991 VL 202 BP 37 EP CINF PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HG080 UT WOS:A1991HG08001345 ER PT J AU JAYASURIYA, K AF JAYASURIYA, K TI A COMPUTATIONAL INVESTIGATION OF PHOSPHAALKYNES - A NEW BUILDING BLOCK IN ORGANIC-CHEMISTRY SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CTR ARMAMENT RES DEV & ENGN,PICATINNY ARSENAL,NJ 07806. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 25 PY 1991 VL 202 BP 60 EP COMP PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HG080 UT WOS:A1991HG08001674 ER PT J AU KLAYMAN, DL AGER, AL FLECKENSTEIN, L LIN, AJ AF KLAYMAN, DL AGER, AL FLECKENSTEIN, L LIN, AJ TI AN EFFECTIVE TREATMENT OF PLASMODIUM-BERGHEI-INFECTED MICE WITH TRANSDERMAL ARTELINIC ACID SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. UNIV MIAMI,CTR TROP PARASIT DIS,MIAMI,FL 33177. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 25 PY 1991 VL 202 BP 63 EP MEDI PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HG080 UT WOS:A1991HG08002528 ER PT J AU SLOAN, JM CHEN, MF AF SLOAN, JM CHEN, MF TI SPECTROSCOPIC STUDIES OF ION-IMPLANTED POLYCARBONATES SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,MAT TECHNOL LAB,POLYMER RES BRANCH,WATERTOWN,MA 02172. USA,MAT TECHNOL LAB,CERAM RES BRANCH,WATERTOWN,MA 02172. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 25 PY 1991 VL 202 BP 81 EP POLY PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HG081 UT WOS:A1991HG08100983 ER PT J AU MAYER, J BALL, D STOTE, R WRIGHT, J SHUPE, A KAPLAN, D AF MAYER, J BALL, D STOTE, R WRIGHT, J SHUPE, A KAPLAN, D TI PRODUCTION, PROPERTIES, MODIFICATIONS AND BIODEGRADATION OF POLYSACCHARIDES SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 25 PY 1991 VL 202 BP 131 EP CHED PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HG080 UT WOS:A1991HG08001174 ER PT J AU GABRIELSEN, B MONATH, TP HUGGINS, JW KIRSI, J HOLLINGSHEAD, M SHANNON, W PETTIT, GR GROSZEK, G AF GABRIELSEN, B MONATH, TP HUGGINS, JW KIRSI, J HOLLINGSHEAD, M SHANNON, W PETTIT, GR GROSZEK, G TI COULD HIPPOCRATES HAVE TREATED VIRAL-INFECTIONS - OR THE ACTIVITY OF SELECTED AMARYLLIDACEAE CONSTITUENTS AND RELATED SYNTHETIC SUBSTANCES IN THE USAMRIID ANTIVIRAL SCREEN OF EXOTIC RNA VIRUSES SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. SO RES INST,BIRMINGHAM,AL 35255. ARIZONA STATE UNIV,CANC RES INST,TEMPE,AZ 85287. ARIZONA STATE UNIV,DEPT CHEM,TEMPE,AZ 85287. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 25 PY 1991 VL 202 BP 165 EP AGFD PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HG080 UT WOS:A1991HG08000167 ER PT J AU YEH, HR AF YEH, HR TI INHIBITION OF HORSERADISH-PEROXIDASE BY 2-CHLOROETHYL SULFIDES AND THIODIGLYCOL SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 25 PY 1991 VL 202 BP 249 EP BIOT PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HG080 UT WOS:A1991HG08000755 ER PT J AU MUNAVALLI, S ROSSMAN, DI ROHRBAUGH, DK FERGUSON, CP BANKS, HD AF MUNAVALLI, S ROSSMAN, DI ROHRBAUGH, DK FERGUSON, CP BANKS, HD TI SINGLE ELECTRON-TRANSFER CATALYZED CLEAVAGE OF THE C-S AND S-S BONDS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 GEOCENTERS INC,ABERDEEN PROVING GROUND,MD 21010. USA,CRDEC,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 25 PY 1991 VL 202 BP 251 EP ORGN PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HG081 UT WOS:A1991HG08100344 ER PT J AU MUNAVALLI, S ROSSMAN, DI ROHRBAUGH, DK FERGUSON, CP HSU, FL AF MUNAVALLI, S ROSSMAN, DI ROHRBAUGH, DK FERGUSON, CP HSU, FL TI SULFUR-SULFUR BOND SCISSION BY A COPPER REAGENT SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 GEOCENTERS INC,FT WASHINGTON,MD 20744. USA,CRDEC,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 25 PY 1991 VL 202 BP 252 EP ORGN PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HG081 UT WOS:A1991HG08100345 ER PT J AU MUNAVALLI, S ROSSMAN, DI ROHRBAUGH, DK FERGUSON, CP SZAFRANIEC, LJ AF MUNAVALLI, S ROSSMAN, DI ROHRBAUGH, DK FERGUSON, CP SZAFRANIEC, LJ TI GRIGNARD-REAGENT PROMOTED SCISSION OF THE C-S AND S-S BONDS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 GEOCENTERS INC,ABERDEEN PROVING GROUND,MD 21010. USA,CRDEC,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 25 PY 1991 VL 202 BP 253 EP ORGN PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HG081 UT WOS:A1991HG08100346 ER PT J AU DAMAVARAPU, R IYER, S BASHIRHASHEMI, A AF DAMAVARAPU, R IYER, S BASHIRHASHEMI, A TI SAFE AND PRACTICAL SYNTHESIS OF NITROCUBANES SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 GEOCENTERS INC,LAKE HOPATCONG,NJ 07849. USA,CTR RES & DEV,PICATINNY ARSENAL,NJ 07806. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 25 PY 1991 VL 202 BP 257 EP ORGN PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HG081 UT WOS:A1991HG08100350 ER PT J AU KRISHNAN, PN BURKE, LA FAMINI, GR JENSEN, JO AF KRISHNAN, PN BURKE, LA FAMINI, GR JENSEN, JO TI THEORETICAL-STUDIES OF GAUCHE AND ECLIPSING INTERACTIONS FOR MODEL COMPOUNDS OF POLYMERS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 COPPIN STATE COLL,DEPT NAT SCI,BALTIMORE,MD 21216. RUTGERS STATE UNIV,DEPT CHEM,CAMDEN,NJ 08102. USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 25 PY 1991 VL 202 BP 353 EP POLY PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HG081 UT WOS:A1991HG08101252 ER PT J AU KUSTIN, K ROBERTS, W TAUB, IA AF KUSTIN, K ROBERTS, W TAUB, IA TI A MECHANISM FOR THE IRON-PROMOTED, MAGNESIUM-WATER REACTION SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 BRANDEIS UNIV,DEPT CHEM,WALTHAM,MA 02254. USA,NATICK RES DEV & ENGN CTR,FOOD ENGN DIRECTORATE,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 25 PY 1991 VL 202 BP 394 EP INOR PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HG080 UT WOS:A1991HG08002447 ER PT J AU KEITH, J WILEY, B BALL, D ARCIDIACONO, S ZORFASS, D MAYER, J KAPLAN, D AF KEITH, J WILEY, B BALL, D ARCIDIACONO, S ZORFASS, D MAYER, J KAPLAN, D TI CONTINUOUS CULTURE SYSTEM FOR PRODUCTION OF BIOPOLYMER LEVAN USING ERWINIA-HERBICOLA SO BIOTECHNOLOGY AND BIOENGINEERING LA English DT Note DE LEVAN; CONTINUOUS CULTURE; MOLECULAR WEIGHT; ERWINIA-HERBICOLA ID SIZE EXCLUSION CHROMATOGRAPHY; LASER-LIGHT SCATTERING; STREPTOCOCCUS-SALIVARIUS; PURIFICATION AB The optimal production of the fructan biopolymer levan by the bacterium Erwinia herbicola was investigated, including variations in nitrogen, carbon and phosphorous sources, pH, incubation time, culture methodology, and polymer processing. Levan yields up to 19% by weight were produced based on conversion of sucrose as the carbon source when grown in a continuous culture system and processed by tangential flow filtration. Product identity was confirmed with gas chromatography (GC) and C-13 nuclear magnetic resonance (NMR). Gel permeation chromatography (GPC) and low-angle laser light scattering (LALLS) determination of the molecular weight of the product showed a significant difference in molecular weight values dependent on the method of analysis. Analysis by GPC resulted in a molecular weight one order of magnitude lower than LALLS independent of sample, underscoring the unusual nature of this biopolymer. RP KEITH, J (reprint author), USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760, USA. NR 17 TC 39 Z9 40 U1 1 U2 6 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0006-3592 J9 BIOTECHNOL BIOENG JI Biotechnol. Bioeng. PD AUG 20 PY 1991 VL 38 IS 5 BP 557 EP 560 DI 10.1002/bit.260380515 PG 4 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA FZ261 UT WOS:A1991FZ26100014 PM 18604815 ER PT J AU EVANS, CP WALSH, DS KOHN, EC AF EVANS, CP WALSH, DS KOHN, EC TI AN AUTOCRINE MOTILITY FACTOR SECRETED BY THE DUNNING R-3327 RAT PROSTATIC ADENOCARCINOMA CELL SUBTYPE-AT2.1 SO INTERNATIONAL JOURNAL OF CANCER LA English DT Article ID HUMAN-MELANOMA CELLS; ADENYLATE-CYCLASE; METASTATIC ABILITY; GRADING SYSTEM; TUMOR-CELLS; CANCER; MODEL; PROTEINS; PREDICTION; CHEMOTAXIS AB Tumor cell locomotion is an integral part of the metastatic process. We present a new autocrine motility factor (AMF) derived from the serum-free conditioned medium of the Dunning R-3327 rat prostate adenocarcinoma AT2.1 tumor cell subline AT2.1-AMF, prepared by concentration of components less-than-or-equal-to 30 kDa in size and washed free of low-molecular-weight growth factors, stimulated motility of AT2.1 cells in modified Boyden chamber migration assays. This stimulated migration was dose-dependent, and by checkerboard analysis was both chemotactic and chemokinetic. AT2.1-AMF activity was labile to heat, acid, base, reduction, oxidation, and proteases. Lyophilization and treatment with 6M urea caused a mild decrease (< 20%) in migration-stimulating capability. Tumor-cell specificity was demonstrated for AMF of AT2.1 and AT3.1 Dunning sublines, and the A2058 human melanoma cell lines. AT2.1 cell migration to AT2.1-AMF was inhibited by 2 hr pre-treatment with chlorea toxin (0.1-mu-g/ml) or forskolin (100-mu-M), but not altered by 2 hr pre-treatment with pertussis toxin (1.0-mu-g/ml). This indicates that guanine nucleotide binding protein-mediated regulation of cAMP is involved in modulating the AT2.1 cell response to its AMF. The AT2.1-AMF belongs to a related family of tumor autocrine motility factors and represents a new model for understanding the role of tumor-cell migration in the metastatic process of human prostate cancer. C1 NCI,MED BRANCH,BLDG 10,ROOM 2A33,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,DIV SURG,WASHINGTON,DC 20307. NR 36 TC 39 Z9 39 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0020-7136 J9 INT J CANCER JI Int. J. Cancer PD AUG 19 PY 1991 VL 49 IS 1 BP 109 EP 113 DI 10.1002/ijc.2910490120 PG 5 WC Oncology SC Oncology GA GB773 UT WOS:A1991GB77300019 PM 1874563 ER PT J AU POSNER, GH OH, CH MILHOUS, WK AF POSNER, GH OH, CH MILHOUS, WK TI OLEFIN OXIDATIVE CLEAVAGE AND DIOXETANE FORMATION USING TRIETHYLSILYL HYDROTRIOXIDE - APPLICATIONS TO PREPARATION OF POTENT ANTIMALARIAL 1,2,4-TRIOXANES SO TETRAHEDRON LETTERS LA English DT Article ID ARTEMISINIC ACID; ANALOGS; CONVERSION; CHEMISTRY AB Oxidative cleavage of alkenyl esters and ethers using Et3SiOOOH was found to be easier than oxidative cleavage of hydrocarbon alkenes, and Et3SiOOOH was successfully applied to very short syntheses of new, simple, and potent antimalarial trioxanes 6 and 8. C1 WALTER REED ARMY MED CTR, DIV EXPTL THERAPEUT, WASHINGTON, DC 20307 USA. RP POSNER, GH (reprint author), JOHNS HOPKINS UNIV, DEPT CHEM, BALTIMORE, MD 21218 USA. NR 27 TC 39 Z9 40 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0040-4039 J9 TETRAHEDRON LETT JI Tetrahedron Lett. PD AUG 19 PY 1991 VL 32 IS 34 BP 4235 EP 4238 DI 10.1016/S0040-4039(00)92136-1 PG 4 WC Chemistry, Organic SC Chemistry GA GC889 UT WOS:A1991GC88900003 ER PT J AU CRAMER, CJ AF CRAMER, CJ TI DEPENDENCE OF ISOTROPIC HYPERFINE COUPLING IN THE FLUOROMETHYL RADICAL SERIES ON INVERSION ANGLE SO JOURNAL OF ORGANIC CHEMISTRY LA English DT Article ID ELECTRON-SPIN-RESONANCE; ABINITIO CONFIGURATION-INTERACTION; MOLECULAR-ORBITAL METHODS; GROUND-STATE STRUCTURE; NEON MATRICES; PARAMAGNETIC-RESONANCE; HYDROCARBON RADICALS; SPLITTING CONSTANTS; CI INVESTIGATIONS; WAVE-FUNCTIONS RP CRAMER, CJ (reprint author), USA,CTR CHEM RES DEV & ENGN,RES DIRECTORATE,DIV PHYS,ABERDEEN PROVING GROUND,MD 21010, USA. RI Cramer, Christopher/B-6179-2011 OI Cramer, Christopher/0000-0001-5048-1859 NR 58 TC 14 Z9 14 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-3263 J9 J ORG CHEM JI J. Org. Chem. PD AUG 16 PY 1991 VL 56 IS 17 BP 5229 EP 5232 DI 10.1021/jo00017a047 PG 4 WC Chemistry, Organic SC Chemistry GA GB561 UT WOS:A1991GB56100047 ER PT J AU MCCANN, UD PENETAR, DM BELENKY, G AF MCCANN, UD PENETAR, DM BELENKY, G TI PANIC ATTACKS IN HEALTHY-VOLUNTEERS TREATED WITH A CATECHOLAMINE SYNTHESIS INHIBITOR SO BIOLOGICAL PSYCHIATRY LA English DT Note ID DISORDER; SLEEP; ANXIETY C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PSYCHIAT,BETHESDA,MD 20814. RP MCCANN, UD (reprint author), WALTER REED ARMY MED CTR,DEPT BEHAV BIOL,WASHINGTON,DC 20307, USA. NR 17 TC 3 Z9 4 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0006-3223 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD AUG 15 PY 1991 VL 30 IS 4 BP 413 EP 416 DI 10.1016/0006-3223(91)90299-2 PG 4 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA GA214 UT WOS:A1991GA21400013 PM 1680473 ER PT J AU HARTMAN, KR WRIGHT, DG AF HARTMAN, KR WRIGHT, DG TI IDENTIFICATION OF AUTOANTIBODIES SPECIFIC FOR THE NEUTROPHIL ADHESION GLYCOPROTEINS CD11B/CD18 IN PATIENTS WITH AUTOIMMUNE NEUTROPENIA SO BLOOD LA English DT Article ID MONOCLONAL-ANTIBODY; LEUKOCYTE FUNCTION; FELTYS SYNDROME; C3BI RECEPTOR; CHRONIC ITP; DEFICIENCY; COMPLEX; THROMBOCYTOPENIA; ADHERENCE; INVITRO RP HARTMAN, KR (reprint author), WALTER REED ARMY MED CTR,DEPT HEMATOL,BLDG 40,WASHINGTON,DC 20307, USA. NR 52 TC 58 Z9 58 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD AUG 15 PY 1991 VL 78 IS 4 BP 1096 EP 1104 PG 9 WC Hematology SC Hematology GA GB208 UT WOS:A1991GB20800029 PM 1678288 ER PT J AU MA, GHM WILLIAMS, BE GLASS, JT PRATER, JT AF MA, GHM WILLIAMS, BE GLASS, JT PRATER, JT TI ANALYSIS VIA TRANSMISSION ELECTRON-MICROSCOPY OF THE QUALITY OF DIAMOND FILMS DEPOSITED FROM THE VAPOR-PHASE SO DIAMOND AND RELATED MATERIALS LA English DT Article ID PLATELET DEFECTS; NATURAL DIAMOND; THIN-FILMS; SURFACE; MORPHOLOGY; PARTICLES; GROWTH AB The quality of diamond films deposited from the vapor phase was analyzed via transmission electron microscopy. Diamond films grown by different deposition processes and under various conditions were examined and the processing microstructure relationships were established. Defect structures are first reviewed here. Twinning was the predominant defect observed in all of the diamond samples, but stacking faults and dislocations were also found. It was found that a lower methane concentration resulted in a lower defect density (higher quality) in diamond films grown by microwave-plasma-enhanced chemical vapor deposition. The defect density in diamond films was also reduced if reverse bias was applied in a bias-controlled hot-filament chemical vapor deposition system, in contrast with the high defect density which occurred under the forward bias condition. Finally, the imperfection density was substantially reduced if diamond films were grown at higher substrate temperatures in an oxyacetylene torch. C1 N CAROLINA STATE UNIV, DEPT MAT SCI & ENGN, RALEIGH, NC 27695 USA. USA, RES OFF, RES TRIANGLE PK, NC 27709 USA. RI Glass, Jeffrey/A-2266-2010 OI Glass, Jeffrey/0000-0002-9554-4398 NR 32 TC 24 Z9 24 U1 0 U2 2 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0925-9635 J9 DIAM RELAT MATER JI Diam. Relat. Mat. PD AUG 15 PY 1991 VL 1 IS 1 BP 25 EP 32 DI 10.1016/0925-9635(91)90008-X PG 8 WC Materials Science, Multidisciplinary SC Materials Science GA JE676 UT WOS:A1991JE67600005 ER PT J AU FLEMISH, JR SHEN, H JONES, KA DUTTA, M BAN, VS AF FLEMISH, JR SHEN, H JONES, KA DUTTA, M BAN, VS TI DETERMINATION OF THE COMPOSITION OF STRAINED INGAASP LAYERS ON INP SUBSTRATES USING PHOTOREFLECTANCE AND DOUBLE-CRYSTAL X-RAY-DIFFRACTOMETRY SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID BAND-GAP; MODULATION SPECTROSCOPY; QUATERNARY ALLOYS; LATTICE-CONSTANT; EPITAXIAL LAYERS; GROWTH; MISMATCH; STRESS AB Determining the composition of strained InGaAsP films through measurements of the lattice spacings and band-gap energies (E(g)) requires converting the measured values to ones which would correspond to unstrained material. In strained layers the lattice constants perpendicular and parallel to the growth plane can vary significantly from the relaxed value, and the optically measured E(g) is affected by a strain-induced splitting of the valence band and a shifting of the direct gap energy. By combining double-crystal x-ray data with room-temperature photoreflectance results, we determine the InGaAsP composition accurately using an iterative procedure. Film compositions calculated using strain adjusted values of E(g) agree with those determined by energy dispersive spectroscopy to within 1-2 at.%, whereas if energy shifts are not considered, the error approaches 10 at.% for strain on the order of 0.4%. C1 EPITAXX INC,PRINCETON,NJ 08540. RP FLEMISH, JR (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. NR 26 TC 13 Z9 13 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD AUG 15 PY 1991 VL 70 IS 4 BP 2152 EP 2155 DI 10.1063/1.349452 PG 4 WC Physics, Applied SC Physics GA GC098 UT WOS:A1991GC09800035 ER PT J AU REGISTER, LF STROSCIO, MA LITTLEJOHN, MA AF REGISTER, LF STROSCIO, MA LITTLEJOHN, MA TI CONSTRAINTS ON THE POLAR-OPTICAL-PHONON INFLUENCE FUNCTIONAL IN HETEROSTRUCTURES SO PHYSICAL REVIEW B LA English DT Article ID DEVICE APPLICATIONS; MODES; WIRE AB The Feynman influence functional for the polar coupling of carriers to confined phonon modes in heterostructures is considered. It is found that the partial contributions to the total influence functional from the individual branches of the optical-phonon energy spectrum are related and constrained by conservation relations. The derivation of these conservation relations requires no specific functional form for the phonon modes; rather it employs only the inherent orthogonality and mathematical completeness of the classical vibrational modes over the crystal-lattice degrees of freedom. In the bulk-crystal limit these conservation relations lead to the familiar results of Feynman; for arbitrary heterostructures, these conservation relations provide a basis for an estimation of the influence functional from limited knowledge of the spatial confinement of the individual phonon branches. C1 UNIV ILLINOIS,BECKMAN INST,URBANA,IL 61801. UNIV ILLINOIS,COORDINATED SCI LAB,URBANA,IL 61801. USA,RES OFF,RES TRIANGLE PK,NC 27709. RP REGISTER, LF (reprint author), N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695, USA. NR 22 TC 2 Z9 2 U1 0 U2 0 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD AUG 15 PY 1991 VL 44 IS 8 BP 3850 EP 3853 DI 10.1103/PhysRevB.44.3850 PG 4 WC Physics, Condensed Matter SC Physics GA GC995 UT WOS:A1991GC99500036 ER PT J AU KIANG, JG AF KIANG, JG TI EFFECT OF INTRACELLULAR PH ON CYTOSOLIC FREE [CA2+] IN HUMAN EPIDERMOID A-431 CELLS SO EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION LA English DT Article DE PHI; CA2+; CA2+ CHANNELS; 1,2-BIS(ORTHO-AMINOPHENOXY)ETHANE-N,N,N',N'-TETRAACETIC ACID (BAPTA); EPITHELIA; CYCLIC AMP; AMILORIDE; NA+/CA2+ EXCHANGER ID NA+-H+ EXCHANGE; GROWTH-FACTOR RECEPTOR; ASCITES TUMOR-CELLS; CA-2+ INFLUX; A431 CELLS; SIGNAL TRANSDUCTION; EXTRACELLULAR PH; SNAIL NEURONS; CALCIUM; ACTIVATION AB This study characterizes the correlation between intracellular pH (pH(i)) and the cytosolic free Ca2+ concentration ([Ca2+]i) in suspended and adherent human epidermoid A-431 cells. Using the fluorescent dyes 2,7-bis(carboxyethyl)carboxyfluorescein acetoxymethyl ester (BCECF) and fura-2, the resting pH(i) and [Ca2+]i in suspended cells were 7.23 +/- 0.03 and 209 +/- 30 nM; those in adherent cells were 7.28 +/- 0.02 and 87 +/- 5 nM. Removal of external Ca2+ did not change the resting pH(i) but reduced the resting [Ca2+]i, indicating the resting level of [Ca2+]i is in part maintained by an influx of Ca2+ from the external medium. When both suspended and adherent cells were acidified or alkalinized, resting [Ca2+]i was altered. An intracellular acidification induced a fall in [Ca2+]i , and a rise in pH(i) induced a rise in [Ca2+]i. These changes in [Ca2+]i were correlated with an uptake of Ca-45(2+) from the external medium, whereas no Ca2+ efflux occurred. The alteration in [Ca2+]i induced by modification of pH(i) was abolished in the absence of external Ca2+ or by adding 2 mM CoCl2, LaCl3, and attenuated by the addition of 2 mM MnCl2 to the bathing medium. It was insensitive to the voltage-gated Ca2+ channel blockers nifedipine or verapamil (1 mM). CoCl2, LaCl3, and MnCl2 each induced changes in pH(i) and [Ca2+]i but verapamil and nifedipine did not. Because CoCl2, LaCl3, and MnCl2 are also known to block Na+/Ca2+ exchange, intracellular Na + ([Na+]i) was measured by flame photometry in acidified or alkalinized cells. In either case no change in [Na+]i was observed. Furthermore, treatment with amiloride (100-mu-M), a blocker of the Na+/Ca2+ exchanger, did not inhibit the pH-induced changes in [Ca2+]i. 1,2-bis(o-Aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA) (100-mu-M), a Ca2+ chelator, induced a decrease in pH(i) as well as a reduction of [Ca2+]i, also supporting the direct relation between pH(i) and [Ca2+]i. 3,4,5-Trimethoxybenzoic acid 8-(diethylamino)octyl ester HCl (TMB-8) (100-mu-M), a known blocker of intracellular Ca2+ mobilization, did not change the resting pH(i) and [Ca2+]i in normal cells or cells acidified or alkalinized. This observation, taken together with data from cells incubated in the absence of external Ca2+, suggests intracellular Ca2+ pools are not involved in changes in [Ca2+]i that result from a modification of pH(i). Resting pH(i) and [Ca2+]i in cells treated with either 8-bromo-dibutyryl cAMP (1 mM) or forskolin (150-mu-M) are not changed. These results suggest a positive correlation between pH(i) and [Ca2+]i in human A-431 cells that is primarily due to Ca2+ influx and not related to voltage, second messenger-operated Ca2+ channels, or the Na+/Ca2+ exchange. RP KIANG, JG (reprint author), WALTER REED ARMY MED CTR,DIV MED,DEPT CLIN PHYSIOL,BLDG 40,WASHINGTON,DC 20307, USA. NR 56 TC 27 Z9 27 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0922-4106 J9 EUR J PHARM-MOLEC PH JI Eur. J. Pharmacol.-Molec. Pharmacol. Sect. PD AUG 14 PY 1991 VL 207 IS 4 BP 287 EP 296 DI 10.1016/0922-4106(91)90002-Y PG 10 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA GD885 UT WOS:A1991GD88500002 PM 1664334 ER PT J AU SHERIDAN, RE DESHPANDE, SS LEBEDA, FJ ADLER, M AF SHERIDAN, RE DESHPANDE, SS LEBEDA, FJ ADLER, M TI THE EFFECTS OF PUMILIOTOXIN-B ON SODIUM CURRENTS IN GUINEA-PIG HIPPOCAMPAL-NEURONS SO BRAIN RESEARCH LA English DT Article DE PUMILIOTOXIN-B; SODIUM CHANNEL; HIPPOCAMPUS; SEIZURE; TOXIN; GUINEA PIG ID DART FROGS DENDROBATIDAE; SKELETAL-MUSCLE; BLASTOMA CELLS; CHANNELS; BATRACHOTOXIN; PHARMACOLOGY; ALKALOIDS; CALCIUM; SITES AB The actions of pumiliotoxin-B, extracted from the skin of the frog Dendrobates pumilio, were examined on hippocampal slices and on acutely dissociated hippocampal neurons from the adult guinea pig. Application of 0.5-1-mu-M pumiliotoxin-B to hippocampal slices caused spontaneous, repetitive field discharges in the CA3 subfield. In whole-cell patch-clamp recordings of isolated CA1 and CA3 neurons, 1-2-mu-M pumiliotoxin-B shifted the midpoint of Na+ current activation by -11.4 +/- 1.1 mV. This shift was not dependent upon prior activation of the sodium channel. Pumiliotoxin-B did not block macroscopic Na+ inactivation but did reduce the apparent voltage-dependence of inactivation such that currents decayed faster at membrane potentials more negative than -30 mV. Single-channel recordings of sodium currents from excised membrane patches indicated that pumiliotoxin-B had little or no effect on channel closings due to entry into inactivated state(s) but did increase the rate of channel closings due to reversal of channel opening. The increase in the channel closing rate was consistent with a +8.7 mV shift in voltage sensitivity. Negative shifts in activation and positive shifts in closing rates implied a negative shift in the voltage-dependence of channel opening, suggesting that pumiliotoxin-B increases the rate of Na+ channel opening and closing in cells at rest, which could result in spontaneous activity in the neurons. RP SHERIDAN, RE (reprint author), USA,NEUROTOXICOL BRANCH,SGRDUVYN,ABERDEEN PROVING GROUND,MD 21010, USA. NR 19 TC 6 Z9 6 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0006-8993 J9 BRAIN RES JI Brain Res. PD AUG 9 PY 1991 VL 556 IS 1 BP 53 EP 60 DI 10.1016/0006-8993(91)90546-8 PG 8 WC Neurosciences SC Neurosciences & Neurology GA GD897 UT WOS:A1991GD89700007 PM 1657306 ER PT J AU PATTON, L SHIP, J WELLNER, R AF PATTON, L SHIP, J WELLNER, R TI N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE (W7) STIMULATION OF K+ TRANSPORT IN A HUMAN SALIVARY EPITHELIAL-CELL LINE SO BIOCHEMICAL PHARMACOLOGY LA English DT Article ID POTASSIUM CHANNELS; CALMODULIN ANTAGONISTS; KINASE-C; MEMBRANE; MOBILIZATION; CONDUCTANCE; MODULATION; VESICLES; GLAND; CA-2+ AB Treatment of a human salivary epithelial cell line, HSG-PA, with the calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W7; 20-70-mu-M) increased Rb-86 (K+) influx and efflux in a manner similar to that resulting from muscarinic (carbachol; Cch) or calcium ionophore (A23187) stimulation. Unlike the Cch or A23187 responses, the W7 responses were not blocked by 0.1 mM atropine (muscarinic antagonist) or phorbol-12-myristate-13-acetate (0.1-mu-M). Like Cch- or A23187-stimulated Rb-86 fluxes, W7-stimulated Rb-86 fluxes were substantially blocked by the K+ channel inhibitors quinine (0.25 mM) and scorpion venom-containing charybdotoxin (33-mu-g/mL), while 5 mM tetraethylammonium chloride (K+ channel blocker), furosemide (0.1 mM; Na+, K+, 2Cl- co-transport inhibitor) and ouabain (10-mu-M; Na+, K+-ATPase inhibitor) were ineffective. Purified charybdotoxin (10 nM) also blocked W7-stimulated Rb-86 influx, as well as Rb-86 influx stimulated by Cch or A23187. Although Quin 2 fluorescence measurements indicated that W7 increased free intracellular Ca2+ concentration ([Ca2+]i), the magnitude of the increase appeared to be insufficient to solely account for the W7-stimulated increases in Rb-86 fluxes (i.e. K+ channel activity). Ca2+ was involved in the W7 response, however, as lack of Ca2+ in the incubation medium reduced the W7-stimulated increases in Rb-86 influx and efflux. Taken together, our results suggest that W7 increased K+ fluxes in HSG-PA cells by interacting, directly or indirectly, with the K+ transport machinery (K+ channels) in a manner different from that observed during muscarinic stimulation, and also in a manner not accounted for solely by the formation of a typical muscarinic- or calcium ionophore-generated calcium signal. C1 NIDR, CLIN INVEST & PATIENT CARE BRANCH, BETHESDA, MD 20892 USA. USA, MED RES INST INFECT DIS, DIV PATHOPHYSIOL, FREDERICK, MD 21702 USA. OI Patton, Lauren/0000-0002-8253-4588 NR 35 TC 2 Z9 2 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0006-2952 EI 1873-2968 J9 BIOCHEM PHARMACOL JI Biochem. Pharmacol. PD AUG 8 PY 1991 VL 42 IS 5 BP 1039 EP 1044 DI 10.1016/0006-2952(91)90286-E PG 6 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA GC812 UT WOS:A1991GC81200011 PM 1714731 ER PT J AU KEELER, JR HURST, CG DUNN, MA AF KEELER, JR HURST, CG DUNN, MA TI PYRIDOSTIGMINE USED AS A NERVE AGENT PRETREATMENT UNDER WARTIME CONDITIONS SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Note AB Objective.-To determine the adverse effects of pretreatment with pyridostigmine bromide for nerve agent exposure during wartime. Design. -A retrospective study Setting. - Southwest Asia. Participants. -Personnel who provided medical support to the XVIII Airborne Corps. These medical officers supplied information pertaining to symptoms and disposition of 41 650 soldiers who received pyridostigmine at the onset of hostilities of Operation Desert Storm. Intervention.-Pyridostigmine bromide, 30 mg orally, was self-administered every 8 hours while under the threat of nerve agent attack (for 1 to 7 days). Main Outcome Measure.-Physiologic changes attributable to pyridostigmine that resulted in need for medical attention, discontinuation of the drug, hospitalization, and/or evacuation f rom Southwest Asia. Results.- About half of the population noted physiologic changes that were not incapacitating, such as increased flatus, abdominal cramps, soft stools, and urinary urgency Approximately 1% of the soldiers believed they had effects that warranted medical attention, but fewer than 0.1% had effects sufficient to discontinue the drug. Nonincapacitating symptoms often occurred; however, military mission performance was not impaired. Conclusion.-While under the threat of nerve agent attack, pyridostigmine can be administered to virtually all soldiers. RP KEELER, JR (reprint author), USA,MED RES INST CHEM DEF,SGRD UV YY LTC KEELER,ABERDEEN PROVING GROUND,MD 21010, USA. NR 9 TC 134 Z9 134 U1 1 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD AUG 7 PY 1991 VL 266 IS 5 BP 693 EP 695 DI 10.1001/jama.266.5.693 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA FZ140 UT WOS:A1991FZ14000029 PM 2072481 ER PT J AU BLASER, MJ OLIVARES, A TAYLOR, DN CORNBLATH, DR MCKHANN, GM AF BLASER, MJ OLIVARES, A TAYLOR, DN CORNBLATH, DR MCKHANN, GM TI CAMPYLOBACTER SEROLOGY IN PATIENTS WITH CHINESE PARALYTIC SYNDROME SO LANCET LA English DT Letter ID JEJUNI C1 DEPT VET AFFAIRS MED CTR,NASHVILLE,TN 37232. WALTER REED ARMY MED CTR,DEPT ENTER DIS,WASHINGTON,DC 20307. JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL,BALTIMORE,MD 21205. RP BLASER, MJ (reprint author), VANDERBILT UNIV,MED CTR,SCH MED,DIV INFECT DIS,NASHVILLE,TN 37232, USA. NR 7 TC 18 Z9 20 U1 0 U2 0 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0140-6736 J9 LANCET JI Lancet PD AUG 3 PY 1991 VL 338 IS 8762 BP 308 EP 308 DI 10.1016/0140-6736(91)90447-W PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA FZ565 UT WOS:A1991FZ56500024 PM 1677126 ER PT J AU REDMOND, J PERRY, J SOWRAY, P VUKELJA, SJ DAWSON, N AF REDMOND, J PERRY, J SOWRAY, P VUKELJA, SJ DAWSON, N TI CHEMOTHERAPY OF DISSEMINATED MERKEL-CELL CARCINOMA SO AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS LA English DT Article DE MERKEL-CELL CARCINOMA; COMBINATION CHEMOTHERAPY ID TRABECULAR CARCINOMA; SKIN; TUMOR; EXPERIENCE; RECURRENT; CANCER AB Six patients developed metastatic merkel-cell carcinoma and were treated with a combination chemotherapy frequently used for small-cell lung cancer. Five of six patients had a complete response for a median of 3.5 months. Overall survival from initiation of chemotherapy was a median of 6.5 months. Two patients died from major complications of therapy. C1 BROOKE ARMY MED CTR,HEMATOL ONCOL SERV,SAN ANTONIO,TX. WALTER REED ARMY MED CTR,HEMATOL ONCOL SERV,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. MADIGAN ARMY MED CTR,HEMATOL ONCOL SERV,TACOMA,WA 98431. NR 18 TC 29 Z9 29 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0277-3732 J9 AM J CLIN ONCOL-CANC JI Am. J. Clin. Oncol.-Cancer Clin. Trials PD AUG PY 1991 VL 14 IS 4 BP 305 EP 307 PG 3 WC Oncology SC Oncology GA FX919 UT WOS:A1991FX91900006 PM 1862761 ER PT J AU HAMILL, RL WOODS, JC COOK, BA AF HAMILL, RL WOODS, JC COOK, BA TI CONGENITAL ATRANSFERRINEMIA - A CASE-REPORT AND REVIEW OF THE LITERATURE SO AMERICAN JOURNAL OF CLINICAL PATHOLOGY LA English DT Article DE CONGENITAL ATRANSFERRINEMIA; ANEMIA; HEMOSIDEROSIS; THERAPY AB A four-year-old Polynesian girl with a two-year history of severe microcytic, hypochromic anemia (which was refractory to iron therapy) had a decreased beta-globulin fraction on serum protein electrophoresis, resulting from the absence of the transferrin (TRF) band. Subsequent assays for TRF showed a level below the detectable range. Liver biopsy revealed significant deposition of hemosiderin within hepatocytes and Kupffer cells, in addition to early fibrosis. Two bone marrow aspirates were hypercellular, with decreased myeloid-erythroid ratios. This case represents the eighth reported example of congenital atransferrinemia, a rare, apparently autosomal recessive disease. C1 TRIPLER ARMY MED CTR,DEPT PATHOL,BOX 304,HONOLULU,HI 96859. TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859. NR 11 TC 71 Z9 72 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0002-9173 J9 AM J CLIN PATHOL JI Am. J. Clin. Pathol. PD AUG PY 1991 VL 96 IS 2 BP 215 EP 218 PG 4 WC Pathology SC Pathology GA FZ711 UT WOS:A1991FZ71100012 PM 1862777 ER PT J AU TANAKA, H SAGAWA, S MIKI, K TAJIMA, F FREUND, BJ CLAYBAUGH, JR SHIRAKI, K AF TANAKA, H SAGAWA, S MIKI, K TAJIMA, F FREUND, BJ CLAYBAUGH, JR SHIRAKI, K TI SYMPATHETIC-NERVE ACTIVITY AND RENAL RESPONSES DURING CONTINUOUS NEGATIVE-PRESSURE BREATHING IN HUMANS SO AMERICAN JOURNAL OF PHYSIOLOGY LA English DT Article DE PERONEAL MUSCLE NERVE; URINE FLOW; URINARY SODIUM EXCRETION; NOREPINEPHRINE; ARGININE VASOPRESSIN; ALDOSTERONE; ATRIAL NATRIURETIC PEPTIDES ID TUBULAR SODIUM-REABSORPTION; HEAD-OUT IMMERSION; VOLUME EXPANSION; CONSCIOUS DOGS; PLASMA; MUSCLE; CATECHOLAMINES; NATRIURESIS; VASOPRESSIN; MODULATION AB A stretch stimulus of the cardiopulmonary receptors results in a diuresis and natriuresis in dogs due to a suppression of renal sympathetic nerve activity. In the present experiment, the stretch stimulus in humans was given by means of continuous negative-pressure breathing (CNPB), and muscle sympathetic nerve activity (MSNA), renal responses, and hormones were measured to examine whether MSNA response during CNPB correlated with the usual renal and hormonal responses for stretch stimulus of the cardiopulmonary receptors. Nine healthy males were subjected to CNPB at - 11 mmHg for 60 min. MSNA in the peroneal muscle nerve fascicles was measured continuously before (pre-CNPB), during, and after CNPB (post-CNPB). A step and sustained decrease (P < 0.05) in MSNA (30 +/- 6% for burst frequency and 37 +/- 4% for total activity from pre-CNPB level) was observed during CNPB and it returned to pre-CNPB level at post-CNPB. Urinary excretion increased by 58 +/- 18% (P < 0.05) during CNPB, and the diuresis was entirely osmolal in nature because of a significant increase (P < 0.05) in Na excretion and a constant free-water clearance. The plasma level of norepinephrine decreased significantly (P < 0.05) during CNPB and remained decreased (P < 0.05) at post-CNPB. A twofold increase (P < 0.05) in plasma atrial natriuretic peptide and a 35 +/- 9% reduction (P < 0.05) in plasma renin activity were observed during CNPB, whereas no change was observed in plasma aldosterone and arginine vasopressin. It is concluded that the central blood volume expansion induced by CNPB reduces sympathetic nerve activity as assessed by MSNA and plasma norepinephrine concentration, and that this reduction in sympathetic activity may be involved in the observed natriuresis. C1 UNIV OCCUPAT & ENVIRONM HLTH,SCH MED,DEPT PHYSIOL,1-1 ISEIGAOKA,YAHATANISHI KU,KITAKYUSHU,FUKUOKA 807,JAPAN. TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96859. FU NHLBI NIH HHS [HL-28542] NR 31 TC 18 Z9 18 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0002-9513 J9 AM J PHYSIOL JI Am. J. Physiol. PD AUG PY 1991 VL 261 IS 2 BP R276 EP R282 PN 2 PG 7 WC Physiology SC Physiology GA GC252 UT WOS:A1991GC25200046 PM 1877686 ER PT J AU PUTNAK, R FEIGHNY, R BURROUS, J COCHRAN, M HACKETT, C SMITH, G HOKE, C AF PUTNAK, R FEIGHNY, R BURROUS, J COCHRAN, M HACKETT, C SMITH, G HOKE, C TI DENGUE-1 VIRUS ENVELOPE GLYCOPROTEIN GENE EXPRESSED IN RECOMBINANT BACULOVIRUS ELICITS VIRUS-NEUTRALIZING ANTIBODY IN MICE AND PROTECTS THEM FROM VIRUS CHALLENGE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID YELLOW-FEVER VIRUS; JAPANESE ENCEPHALITIS-VIRUS; STRUCTURAL PROTEINS; MONOCLONAL-ANTIBODIES; INSECT CELLS; POSITIVE IDENTIFICATION; SEQUENCE; VACCINE; CLEAVAGE; SURFACE AB In order to test the feasibility of baculovirus (Autographa californica nuclear polyhedrosis virus, AcNPV) expression vectors for making immunogens against dengue-1 (DEN-1) virus, a portion of the envelope (E) glycoprotein gene of DEN-1 virus was cloned and expressed. The recombinant baculovirus contains 107 nucleotides from the 3' terminus of the DEN-1 matrix (M) gene, which encodes a hydrophobic signal peptide and extends through the first 1, 245 nucleotides of E, terminating 243 nucleotides before the 3' terminus of E. When the recombinant virus was grown in Spodoptera frugiperda cells, about 1 mg of E antigen was made per 10(9) cells. Recombinant E antigen reacted with E protein-specific monoclonal antibodies and stimulated production of DEN-1 virus neutralizing antibody in BALB/c mice. Mice immunized with recombinant E antigen or with heat-inactivated DEN-1 virus were protected significantly against lethal DEN-1 virus challenge. A dose/response effect was observed, with increasing amounts of recombinant antigen leading to increased survival. These results demonstrate the utility of baculovirus for producing immunogens against DEN-1 virus. C1 MICROGENESYS INC,W HAVEN,CT 06516. MOLEC THERAPEUT,W HAVEN,CT 06516. RP PUTNAK, R (reprint author), WALTER REED ARMY MED CTR,DEPT VIRUS DIS,BLDG 40,ROOM 2036,WASHINGTON,DC 20307, USA. NR 43 TC 45 Z9 48 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD AUG PY 1991 VL 45 IS 2 BP 159 EP 167 PG 9 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA GE349 UT WOS:A1991GE34900001 PM 1877710 ER PT J AU SCHOEPP, RJ BEATY, BJ ECKELS, KH AF SCHOEPP, RJ BEATY, BJ ECKELS, KH TI INFECTION OF AEDES-ALBOPICTUS AND AEDES-AEGYPTI MOSQUITOS WITH DENGUE PARENT AND PROGENY CANDIDATE VACCINE VIRUSES - A POSSIBLE MARKER OF HUMAN ATTENUATION SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID PRIMARY KIDNEY-CELLS; RHESUS LUNG-CELLS; SERIAL PASSAGE; ORAL INFECTION; GEOGRAPHIC STRAINS; SUSCEPTIBILITY; SELECTION; TRANSMISSION; VOLUNTEERS; RESPONSES AB Dengue (DEN-1) and DEN-4 parent (P) and progeny candidate vaccine (CV) viruses were compared in their abilities to infect and to replicate in Aedes aegypti and Aedes albopictus mosquitoes. The DEN CV clones were temperature sensitive (ts) and had small plaque morphology. The DEN-1 and DEN-4 CV viruses differed in their ability to infect, to replicate in, and to be transmitted by mosquitoes. The DEN-1 CV virus was not attenuated for the vector mosquitoes; oral infection rates with the CV virus were as high as or higher than the P virus, and the CV virus replicated efficiently in mosquitoes after oral infection. The DEN-4 CV virus was attenuated; it was less efficient than its P virus in infection and replication in mosquitoes. Thus, the ts phenotype and small plaque morphology are not reliable biological markers for prediction of vector attenuation. Similar results were reported by others for attenuation in man and monkeys. These studies with DEN-1 and DEN-4 viruses, and previously reported studies with DEN-2 virus and with DEN-3 virus suggest that vector and vertebrate host attenuation are genetically linked. Thus, vector attenuation may be a biological marker for human attenuation. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BIOL RES,WASHINGTON,DC 20207. RP SCHOEPP, RJ (reprint author), COLORADO STATE UNIV,COLL VET MED & BIOMED SCI,DEPT MICROBIOL,FT COLLINS,CO 80523, USA. NR 40 TC 18 Z9 18 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD AUG PY 1991 VL 45 IS 2 BP 202 EP 210 PG 9 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA GE349 UT WOS:A1991GE34900006 PM 1877715 ER PT J AU AMERASINGHE, FP AMERASINGHE, PH PEIRIS, JSM WIRTZ, RA AF AMERASINGHE, FP AMERASINGHE, PH PEIRIS, JSM WIRTZ, RA TI ANOPHELINE ECOLOGY AND MALARIA INFECTION DURING THE IRRIGATION DEVELOPMENT OF AN AREA OF THE MAHAWELI PROJECT, SRI-LANKA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID PREDEVELOPMENT MOSQUITO SURVEY; PLASMODIUM-FALCIPARUM; CULICIFACIES; CULICIDAE; DIPTERA; VIVAX; ELISA AB A study on adult anopheline ecology and malaria vector incrimination was carried out from 1986 to 1989 during irrigation development in an area of the Mahaweli Project in eastern Sri Lanka. Eleven potential vector species were collected resting indoors or by using human or bovid bait, and from light trap catches. Overall, Anopheles vagus (Donitz), An. annularis (van der Wulp), and An. subpictus (Grassi) were the most prevalent, and An. culicifacies (Giles) and An. barbirostris (van der Wulp) were the least prevalent species. The abundance of An. aconitus (Donitz), An. jamesii (Theobald), An. pallidus (Theobald), and An. subpictus increased after irrigation development, while An. annularis, An. barbirostris, An. culicifacies and An. varuna (Iyengar) decreased. Populations of An. nigerrimus (Giles), An. tessellatus (Theobald), and An. vagus did not change substantially. Seven species were infected with malaria parasites, as determined by enzyme-linked immunosorbent assays (ELISA) done on mosquito head-thorax triturates. The main species involved were An. annularis, at peak abundance during the 1986-1987 period of development leading to the onset of irrigation, and An. subpictus, during times of seasonal abundance in the post-irrigation period of 1988 to 1989. Although occurring at low abundance, An. culicifacies was involved in malaria transmission irregularly throughout the study period. While there was strong ELISA-based evidence implicating An. subpictus as a major post-irrigation vector, confirmation of its vector status must await dissection and ELISA-based evidence of P. vivax and P. falciparum sporozoite infection rates in salivary glands. C1 ROYAL VICTORIA INFIRM,DEPT VIROL,NEWCASTLE TYNE NE1 4LP,TYNE & WEAR,ENGLAND. WALTER REED ARMY MED CTR,ENTOMOL BRANCH,WASHINGTON,DC 20307. UNIV PERADENIYA,DEPT ZOOL,PERADENIYA,SRI LANKA. UNIV PERADENIYA,DEPT MICROBIOL,PERADENIYA,SRI LANKA. NR 32 TC 47 Z9 48 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD AUG PY 1991 VL 45 IS 2 BP 226 EP 235 PG 10 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA GE349 UT WOS:A1991GE34900009 PM 1877717 ER PT J AU EDWARDS, FH TAYLOR, AJ THOMPSON, L ROGAN, KM PEZZELLA, AT BURGE, JR HETZLER, N AF EDWARDS, FH TAYLOR, AJ THOMPSON, L ROGAN, KM PEZZELLA, AT BURGE, JR HETZLER, N TI CURRENT STATUS OF CORONARY-ARTERY OPERATION IN SEPTUAGENARIANS SO ANNALS OF THORACIC SURGERY LA English DT Article ID BYPASS-SURGERY; CARDIAC-SURGERY; MORTALITY; MORBIDITY; AGE; OLDER AB Previous reports of elderly patients undergoing coronary artery bypass grafting have not addressed the current era of aggressive percutaneous angioplasty and frequent urgent or emergent operation. To investigate this important subgroup of patients, we analyzed our recent coronary artery bypass grafting experience with patients 70 years of age or older. From January 1984 to January 1989, 121 consecutive patients in this age range underwent surgical revascularization at our institution. Overall in-hospital operative mortality (OM) was 7.4% (9/121), with 77.8% (7/9) of deaths due to cardiac causes. Serious postoperative morbidity occurred in 71.1% (86/121). Surgical priority was significantly correlated with operative mortality: for elective cases, the OM was 2.9% (2/68), but it was 8.6% (3/35) for urgent cases (p < 0.05) and 22.2% (4/18) for emergency cases (p < 0.05). Univariate analysis isolated the need for inotropic support, intraaortic balloon pump, reoperation, cardiopulmonary resuscitation, and emergency status as significant risk factors for OM (p < 0.05). Multivariate stepwise logistic regression analysis identified the need for inotropic support, intravenous nitroglycerin, reoperative coronary artery bypass grafting, and hypertension as independently significant risk factors. A logistic risk equation developed from this population accurately modeled OM at the extremes of operative risk. Three (3.1%) of the 97 patients predicted to have less than 5% OM died, whereas all patients predicted by the model to have greater than 90% OM died. These results indicate that in spite of relatively high morbidity and mortality rates, elderly patients have a very acceptable operative risk in the current era of high-risk coronary artery bypass grafting. This is particularly true if elective revascularization is possible. C1 WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. RP EDWARDS, FH (reprint author), WALTER REED ARMY MED CTR,DEPT SURG,WASHINGTON,DC 20307, USA. NR 20 TC 33 Z9 33 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0003-4975 J9 ANN THORAC SURG JI Ann. Thorac. Surg. PD AUG PY 1991 VL 52 IS 2 BP 265 EP 269 PG 5 WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery SC Cardiovascular System & Cardiology; Respiratory System; Surgery GA GB137 UT WOS:A1991GB13700016 PM 1863148 ER PT J AU BARKO, JW GUNNISON, D CARPENTER, SR AF BARKO, JW GUNNISON, D CARPENTER, SR TI SEDIMENT INTERACTIONS WITH SUBMERSED MACROPHYTE GROWTH AND COMMUNITY DYNAMICS SO AQUATIC BOTANY LA English DT Review ID FRESH-WATER MACROPHYTES; EELGRASS-ZOSTERA-MARINA; HALODULE-WRIGHTII ASCHERS; MYRIOPHYLLUM-SPICATUM L; DRY-WEIGHT LOSS; AQUATIC MACROPHYTES; POTAMOGETON-PECTINATUS; EUTROPHIC LAKE; NUTRIENT AVAILABILITY; PHOSPHORUS ENRICHMENT AB We review and synthesize information available in the literature on sediment interactions with submersed macrophyte growth and community dynamics. Sources of particular nutrients for uptake by submersed macrophytes are critically evaluated. Sediment physical and chemical properties are considered as a product of macrophyte growth as well as potential delimiters of growth. Aspects of macrophyte nutrition that influence littoral nutrient dynamics and macrophyte community composition are highlighted, with attention to factors affecting sediment nutrient availability. Interactive effects of sediment nutrient depletion, sedimentation, bioturbation, and microbial activity on macrophyte growth are emphasized. Major linkages and feedbacks between aquatic macrophytes and sediment properties are considered in terms of elemental exchanges and responses at the ecosystem level. Changes in macrophyte community composition during lake aging, or over relatively shorter time periods, are suggested to occur partially in response to altered sediment properties. C1 UNIV WISCONSIN,CTR LIMNOL,MADISON,WI 53706. RP BARKO, JW (reprint author), WATERWAYS EXPT STN,ENVIRONM LAB,VICKSBURG,MS 39180, USA. NR 136 TC 313 Z9 366 U1 9 U2 92 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3770 J9 AQUAT BOT JI Aquat. Bot. PD AUG PY 1991 VL 41 IS 1-3 BP 41 EP 65 DI 10.1016/0304-3770(91)90038-7 PG 25 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA GD573 UT WOS:A1991GD57300003 ER PT J AU SMITH, WJ DUNN, MA AF SMITH, WJ DUNN, MA TI MEDICAL DEFENSE AGAINST BLISTERING CHEMICAL WARFARE AGENTS SO ARCHIVES OF DERMATOLOGY LA English DT Article ID SULFUR MUSTARD TOXICITY; NAD+ LEVELS; GAS; SKIN; THIODIGLYCOL; SULFIDE; URINE AB First used in World War I, chemical blistering agents present a serious medical threat that has stimulated renewed interest in the light of extensive use in recent conflicts. Current medical management cannot yet prevent or minimize injury from the principal agent of concern-sulfur mustard. Research directed at this goal depends on defining effective intervention in the metabolic alterations induced by exposure to sulfur mustard. RP SMITH, WJ (reprint author), USA,MED RES INST CHEM DEF,BIOCHEM PHARMACOL BRANCH,SGRD,UV PB,ABERDEEN PROVING GROUND,MD 21010, USA. NR 59 TC 101 Z9 103 U1 0 U2 3 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD AUG PY 1991 VL 127 IS 8 BP 1207 EP 1213 DI 10.1001/archderm.127.8.1207 PG 7 WC Dermatology SC Dermatology GA GA977 UT WOS:A1991GA97700015 PM 1863081 ER PT J AU SOLIS, J SAU, P JAMES, WD AF SOLIS, J SAU, P JAMES, WD TI PUZZLING PALMAR AND PLANTAR PAPULES - POROKERATOTIC ECCRINE OSTIAL AND DERMAL DUCT NEVUS SO ARCHIVES OF DERMATOLOGY LA English DT Note C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP SOLIS, J (reprint author), KELLER ARMY HOSP,W POINT,NY 10996, USA. NR 9 TC 3 Z9 3 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD AUG PY 1991 VL 127 IS 8 BP 1219 EP & PG 0 WC Dermatology SC Dermatology GA GA977 UT WOS:A1991GA97700019 ER PT J AU OMORI, DM POTYK, RP KROENKE, K AF OMORI, DM POTYK, RP KROENKE, K TI THE ADVERSE-EFFECTS OF HOSPITALIZATION ON DRUG REGIMENS SO ARCHIVES OF INTERNAL MEDICINE LA English DT Article ID PATIENT COMPLIANCE; DISCHARGE; MEDICATIONS AB To determine the effect of hospitalization on errors in patients' drug regimens, 157 consecutive patients discharged on regimens of four or more drugs were identified, of whom 94 were eligible for study. Thirty-four (79%) of 43 local patients were interviewed within 1 month after discharge, and 28 (55%) of 51 patients who were mailed a questionnaire responded. Regimen errors were detected in 50% of both groups. Overall, 20 (32%) of 62 patients had incorrectly added or deleted a drug, and 11 (18%) were taking the correct drugs but had errors in dosing. Twelve potentially serious errors were detected. Patients with regimen errors had been discharged taking more drugs (6.1 vs 5.10) and tended to have more drug changes during hospitalization (2.7 vs 1.90). Particular attention should be paid to drug regimens during hospitalization and in subsequent follow-up visits. C1 BROOKE ARMY MED CTR,DEPT PHARM,SAN ANTONIO,TX. WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. BROOKE ARMY MED CTR,DEPT MED,SAN ANTONIO,TX. NR 14 TC 40 Z9 40 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD AUG PY 1991 VL 151 IS 8 BP 1562 EP 1564 DI 10.1001/archinte.151.8.1562 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA GB722 UT WOS:A1991GB72200011 PM 1872660 ER PT J AU JOBE, JB SHUKITTHALE, B BANDERET, LE ROCK, PB AF JOBE, JB SHUKITTHALE, B BANDERET, LE ROCK, PB TI EFFECTS OF DEXAMETHASONE AND HIGH TERRESTRIAL ALTITUDE ON COGNITIVE PERFORMANCE AND AFFECT SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID ACUTE MOUNTAIN-SICKNESS; ACETAZOLAMIDE AB This study examined the effects of dexamethasone and exposure to high terrestrial altitude on cognitive performance, affect, and personality. Cognitive performance was evaluated by five cognitive tasks, affect was evaluated by the Clyde Mood Scale and the Multiple Affect Adjective Check List, and personality was examined using the Minnesota Multiphasic Personality Inventory. Sixteen healthy young men received either dexamethasone (4 mg every 6 h) (n = 7) or placebo (n = 9) for 34 h prior to and 52 h after ascent to 4,300 m. Subjects treated with dexamethasone correctly performed more computer interaction and addition problems than did placebo-treated subjects. They also were less sleepy, dizzy, depressed, and anxious than placebo-treated subjects at altitude. No adverse effects on cognitive performance, affect, or personality were noted after dexamethasone was discontinued on the third day at altitude. Results indicated that dexamethasone at the present dose positively influences cognitive performance and mood states at altitude, but has no residual effect on personality. C1 USA,ENVIRONM MED RES INST,DIV HLTH & PERFORMANCE,NATICK,MA 01760. NATL CTR HLTH STAT,OFF RES & METHODOL,HYATTSVILLE,MD 20782. NR 28 TC 12 Z9 12 U1 0 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD AUG PY 1991 VL 62 IS 8 BP 727 EP 732 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA FZ249 UT WOS:A1991FZ24900003 PM 1930053 ER PT J AU KRAEMER, WJ HAMILTON, AJ GORDON, SE TRAD, LA REEVES, JT ZAHN, DW CYMERMAN, A AF KRAEMER, WJ HAMILTON, AJ GORDON, SE TRAD, LA REEVES, JT ZAHN, DW CYMERMAN, A TI PLASMA CHANGES IN BETA-ENDORPHIN TO ACUTE HYPOBARIC HYPOXIA AND HIGH-INTENSITY EXERCISE SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID CORTISOL RESPONSES; ENDOGENOUS OPIOIDS; MODERATE-ALTITUDE; GRADED-EXERCISE; ADRENOCORTICOTROPIN; ALDOSTERONE; INCREASE; HUMANS AB The purpose of this study was to examine the immediate post-exercise effects of acute exposure to a simulated altitude of 4,300 m on plasma concentrations of beta-endorphin (beta-EP) and associated changes of adrenocorticotropin (ACTH), and cortisol to high intensity cycle exercise (i.e., stages of 90 and 100% peak Vo2). Exercise intensities were assigned relative to peak O2 uptake both under sea level conditions and under acute hypobaric hypoxic conditions. Plasma beta-EP concentrations significantly increased from pre- to immediately post-exercise at both 90 and 100% peak Vo2 in both the sea level and acute hypobaric hypoxic trials. No associated exercise-induced changes were observed for ACTH or cortisol pre- to immediately post-exercise at either sea level or during hypoxic conditions. Exercise at acute hypobaric hypoxia elicited no significantly different responses in plasma beta-EP, ACTH, or cortisol than those elicited by the same relative exercise intensities under normobaric normoxic conditions. Additionally, no changes in the beta-EP/ACTH molar ratio for exercise or between conditions were observed. These data indicate that acute simulated high altitude exposure neither diminishes nor augments the physiological stimuli involved with high relative exercise intensity activation mechanisms of these hormones. C1 UNIV ARIZONA,ARIZONA HLTH SCI CTR,TUCSON,AZ 85724. UNIV COLORADO,MED CTR,DEPT SURG,NEUROSURG SECT,BOULDER,CO 80309. USA,ENVIRONM MED RES INST,NATICK,MA 01760. UNIV COLORADO,MED CTR,CARDIOVASC PULM RES LAB,DENVER,CO 80202. RP KRAEMER, WJ (reprint author), PENN STATE UNIV,CTR SPORTS MED,GREENBERG SPORTS COMPLEX,UNIVERSITY PK,PA 16802, USA. NR 26 TC 10 Z9 11 U1 0 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD AUG PY 1991 VL 62 IS 8 BP 754 EP 758 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA FZ249 UT WOS:A1991FZ24900007 PM 1656928 ER PT J AU HAMILTON, AJ TRAD, LA CYMERMAN, A AF HAMILTON, AJ TRAD, LA CYMERMAN, A TI ALTERATIONS IN HUMAN UPPER EXTREMITY MOTOR FUNCTION DURING ACUTE EXPOSURE TO SIMULATED ALTITUDE SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID ACUTE MOUNTAIN-SICKNESS; SOMATOSENSORY EVOKED-RESPONSES; DEXAMETHASONE; HYPOXIA; SYMPTOMS AB We tested the hypothesis that mild motor dysfunction was associated with Acute Mountain Sickness (AMS) by measuring arm movement characteristics in 14 subjects at sea level and at the end of a 30-h simulated altitude exposure (4,600 m). A computerized upper extremity movement analyzer (UEMA) was used to quantitate arm movements between a "start" position and randomly-generated targets on a large digitizing tablet by measuring selected speed parameters and error indices. The UEMA results were compared with the results of the Environmental Symptoms Questionnaire (ESQ) and with neurologic examinations. When compared with sea-level values, the mean values for all the speed-related parameters measured at the end of the 30-h exposure significantly declined by 20% to 32%. The error indices were not different. The declines in the speed-related parameters were significantly correlated with the severity of AMS symptoms as measured by the ESQ (R = 0.82). The neurologic abnormalities were limited to changes in mental status items. These results demonstrate that subclinical alterations in upper extremity speed are associated with mild, reversible AMS and provide evidence that hypoxia may produce supraspinal inhibition of motor pathways. C1 USA,ENVIRONM MED RES INST,ALTITUDE RES DIV,NATICK,MA 01760. MASSACHUSETTS GEN HOSP,NEUROSURG SERV,BOSTON,MA 02114. HARVARD UNIV,SCH MED,BOSTON,MA 02115. NR 22 TC 15 Z9 16 U1 1 U2 2 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD AUG PY 1991 VL 62 IS 8 BP 759 EP 764 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA FZ249 UT WOS:A1991FZ24900008 PM 1930057 ER PT J AU MITCHELL, GW AF MITCHELL, GW TI RAPID ONSET OF SEVERE HEAT ILLNESS - A CASE-REPORT SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID HELICOPTER AB Aviators flying extended periods in hot environments are known to be at risk for heat-related illness. The risk when wearing chemical individual protective equipment (IPE) is increased even at relatively warm temperatures and light workloads. In this paper, we report the physiological responses of an aviator who had been flying a UH-1H helicopter up to 6 h/d clothed in full IPE on 6 consecutive days prior to the sudden onset of heat illness. His performance during the study was normal, and no clear physiological derangements were noted prior to his symptoms. The rapid evolution of his symptoms after voicing no complaints provides a graphic illustration of the difficult predictability and initial central nervous system effects of this condition. C1 AEROMED CONSULTAT SERV,FLIGHT MED BRANCH,BROOKS AFB,TX. RP MITCHELL, GW (reprint author), USA,AEROMED RES LAB,CTR SCI INFORMAT,POB 577,FT RUCKER,AL 35362, USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD AUG PY 1991 VL 62 IS 8 BP 779 EP 782 PG 4 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA FZ249 UT WOS:A1991FZ24900012 PM 1930061 ER PT J AU MARTEL, CJ DIENER, CJ AF MARTEL, CJ DIENER, CJ TI PILOT-SCALE STUDIES OF SLUDGE DEWATERING IN A FREEZING BED SO CANADIAN JOURNAL OF CIVIL ENGINEERING LA English DT Article DE SLUDGE FREEZING BED; FREEZE THAW CONDITIONING; FREEZE THAW SEPARATION; SLUDGE DEWATERING; FREEZING BED AB In 1986, a pilot-scale sludge freezing bed was constructed at the U.S. Army Cold Regions Research and Engineering Laboratory in Hanover, New Hampshire, U.S.A. This bed was operated for the next three years using both anaerobically and aerobically digested sludges. Results indicate that both sludges were effectively dewatered by this process. The maximum depth of sludge frozen during this study was 1.14 m. The final solid contents were 39.3% and 24.5% for anaerobically digested and aerobically digested sludges respectively. The quality of the meltwater from the bed was similar to raw waste-water. The actual depth of sludge frozen and thawed in the bed during each year of operation was very close to that predicted by design models. Operational experience demonstrated the importance of a sand layer at the bottom of the bed for adequate drainage. Also, odors developed when the meltwater was allowed to accumulate in the bed. Odors were not a problem when the meltwater was drained away as quickly as it formed. Both sludges were easily removed with a front-end loader. RP MARTEL, CJ (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 14 TC 4 Z9 4 U1 1 U2 1 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A 0R6, CANADA SN 0315-1468 J9 CAN J CIVIL ENG JI Can. J. Civ. Eng. PD AUG PY 1991 VL 18 IS 4 BP 681 EP 689 PG 9 WC Engineering, Civil SC Engineering GA GE342 UT WOS:A1991GE34200017 ER PT J AU ASHTON, FE MANCINO, L RYAN, AJ POOLMAN, JT ABDILLAHI, H ZOLLINGER, WD AF ASHTON, FE MANCINO, L RYAN, AJ POOLMAN, JT ABDILLAHI, H ZOLLINGER, WD TI SEROTYPES AND SUBTYPES OF NEISSERIA-MENINGITIDIS SEROGROUP-B STRAINS ASSOCIATED WITH MENINGOCOCCAL DISEASE IN CANADA, 1977-1989 SO CANADIAN JOURNAL OF MICROBIOLOGY LA English DT Article DE MENINGOCOCCAL SEROTYPES; SUBTYPES ID OUTER-MEMBRANE PROTEINS; HUMAN IMMUNE-RESPONSE; WHOLE-CELL ELISA; MONOCLONAL-ANTIBODIES; VACCINE; POLYSACCHARIDE; INFECTION; ANTIGENS; COMPLEX; EPITOPES AB Typing of Neisseria meningitidis serogroup B disease isolates was carried out using a panel of serotype- and subtype-specific monoclonal antibodies (MAbs) in enzyme-linked immunosorbent assays (ELISA). Three hundred and sixty-two strains isolated from 1977 to 1986 were typed using five serotyping and seven subtyping reagents and outer membrane vesicles as antigens. Serotype 2b accounted for 30% of the disease isolates. The most common subtype was P1.2, which occurred on 18.5% of all strains or 48.6% of the serotype 2b strains. Of the 362 strains typed, 135 (37.3%) were serotyped and 122 (33.7%) were subtyped. Overall, 185 (51.1%) of the strains could be assigned a serotype and (or) subtype. Strains (221) isolated during the years 1987-1989 were typed using a panel of 6 serotyping and 12 subtyping reagents by whole-cell ELISA. Strains of serotypes 4 (21.7%) and 15 (20.8%) were the most common and carried a wide variety of subtypes. The most common subtypes were P1.2 (11.8%) and P1.16 (9.5%). Of the 221 strains analyzed, 132 (59.7%) were assigned a serotype and 123 (55.7%) a subtype and with all 18 MAbs, 192 (86.9%) of the strains were serotyped and (or) subtyped. Two different MAbs to the four epitopes 2a, 15, P1.2, and P1.16 gave discordant reactions of 0.3, 6.6, 2.6, and 2.2%, respectively, when used to analyze over 300 strains of N. meningitidis. C1 NATL INST PUBL HLTH & ENVIRONM PROTECT,BILTHOVEN,NETHERLANDS. WALTER REED ARMY MED CTR,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. RP ASHTON, FE (reprint author), LAB CTR DIS CONTROL,BUR MICROBIOL,NATL LAB BACTERIOL,OTTAWA K1A 0L2,ONTARIO,CANADA. NR 47 TC 21 Z9 21 U1 0 U2 0 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A 0R6, CANADA SN 0008-4166 J9 CAN J MICROBIOL JI Can. J. Microbiol. PD AUG PY 1991 VL 37 IS 8 BP 613 EP 617 PG 5 WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Immunology; Microbiology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Immunology; Microbiology GA GH499 UT WOS:A1991GH49900007 PM 1954574 ER PT J AU DILLARD, TA AF DILLARD, TA TI EXERCISE CAPACITY IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY-DISEASE SO CHEST LA English DT Editorial Material ID AIR-FLOW OBSTRUCTION; PREDICTION C1 WALTER REED ARMY MED CTR,PULM FUNCT LAB,WASHINGTON,DC 20307. NR 10 TC 1 Z9 1 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD AUG PY 1991 VL 100 IS 2 BP 297 EP 298 DI 10.1378/chest.100.2.297 PG 2 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA GA196 UT WOS:A1991GA19600001 PM 1864094 ER PT J AU LAZARUS, EF KAPKE, GF AF LAZARUS, EF KAPKE, GF TI USE OF CHEMICAL DENATURATION FOR CENTRIFUGAL ANALYZER DETERMINATION OF LACTATE DEHYDROGENASE-1 SO CLINICAL CHEMISTRY LA English DT Letter RP LAZARUS, EF (reprint author), WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CLINICAL CHEMISTRY PI WASHINGTON PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 SN 0009-9147 J9 CLIN CHEM JI Clin. Chem. PD AUG PY 1991 VL 37 IS 8 BP 1464 EP 1464 PG 1 WC Medical Laboratory Technology SC Medical Laboratory Technology GA GB196 UT WOS:A1991GB19600041 PM 1868617 ER PT J AU ALBERTSON, KS MEDOFF, RJ MITSUNAGA, MM AF ALBERTSON, KS MEDOFF, RJ MITSUNAGA, MM TI THE USE OF PERIOSTEALLY VASCULARIZED AUTOGRAFTS TO AUGMENT THE FIXATION OF LARGE SEGMENTAL ALLOGRAFTS SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Article ID BONE; TRANSPLANTATION; GRAFTS AB Large segmental bone grafts are a standard of reconstructing long bone defects. Nonunion or delayed union at the host-graft junction is a major complication of these procedures. In six patients, a nonunion was treated by locally available bone, vascularized by its periosteum as an onlay autograft to improve fixation and speed incorporation of the allograft into the host bone. At three months, all were pain free and using their allografts without limitation. By four months, all had roentgenographic evidence of allograft and autograft incorporation. During the follow-up period from two to four years, all have incorporated the allografts and are pain free. C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. UNIV HAWAII,HONOLULU,HI 96822. NR 13 TC 13 Z9 14 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0009-921X J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD AUG PY 1991 IS 269 BP 113 EP 119 PG 7 WC Orthopedics; Surgery SC Orthopedics; Surgery GA FZ818 UT WOS:A1991FZ81800018 PM 1864028 ER PT J AU NAKANO, Y TAKEDA, K AF NAKANO, Y TAKEDA, K TI QUASI-STEADY PROBLEMS IN FREEZING SOILS .3. ANALYSIS OF EXPERIMENTAL-DATA SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article ID FROZEN SOIL; ICE LAYER; TRANSPORT; GROWTH; MODEL AB The results of mathematical and experimental studies presented in the two earlier papers in this series (part I and II) on the three distinct and representative models of a frozen fringe, M1, M2 and M3, clearly show that the model M1 is consistent with our experimental data while the empirical evidence against M2 and M3 is overwhelming. In this work the properties of the model M1 are further examined by analyzing the experimental data in detail. We have found that the properties of a frozen fringe based on the model M1 are consistent with the experimental data and that the predicted steady growth condition of an ice layer is in excellent agreement with the condition found empirically. C1 KONOIKE CONSTRUCT CO LTD,TECH RES INST,OSAKA,JAPAN. RP NAKANO, Y (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 23 TC 5 Z9 5 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD AUG PY 1991 VL 19 IS 3 BP 225 EP 243 DI 10.1016/0165-232X(91)90038-I PG 19 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA GD921 UT WOS:A1991GD92100001 ER PT J AU PEROVICH, DK AF PEROVICH, DK TI SEASONAL-CHANGES IN SEA ICE OPTICAL-PROPERTIES DURING FALL FREEZE-UP SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article ID SNOW; REFLECTANCE; MICROALGAE; SURFACES; SOUND AB During the seasonal transition from summer to winter conditions, a sea ice cover undergoes a profound transformation. As the air temperature drops, the ice cools, the brine volume decreases, melt ponds freeze, new ice forms in areas of open water, and the surface becomes snow-covered. There is a corresponding change in the optical properties of the ice cover with albedos increasing and transmittances decreasing. As part of the Coordinated Eastern Arctic Experiment (CEAREX), measurements of spectral albedos, reflectances and incident irradiances were made at visible and near-infrared wave-lengths (400-1100 nm) during fall freeze-up. In general, albedos increased as freeze-up progressed, with the increase being most pronounced at shorter wavelengths. The greatest temporal changes occurred in a freezing lead where, in only a few days, albedos increased from 0.1 for open water to 0.9 for snow-covered young ice. The evolution of the transmitted radiation field under the ice was estimated using a two-stream, multilayer radiative transfer model in conjunction with observations of ice morphology and thickness. Transmission decreased dramatically due to ice cooling, snowfall, and declining incident solar irradiances. Light transmission through young ice was two orders of magnitude greater than through snow-covered multilayer ice. RP PEROVICH, DK (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 27 TC 23 Z9 24 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD AUG PY 1991 VL 19 IS 3 BP 261 EP 273 DI 10.1016/0165-232X(91)90041-E PG 13 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA GD921 UT WOS:A1991GD92100004 ER PT J AU MENDOZA, GA SPROUSE, W LUPPOLD, WG ARAMAN, P MEIMBAN, RJ AF MENDOZA, GA SPROUSE, W LUPPOLD, WG ARAMAN, P MEIMBAN, RJ TI AN INTEGRATED MANAGEMENT SUPPORT AND PRODUCTION CONTROL-SYSTEM FOR HARDWOOD FOREST PRODUCTS SO COMPUTERS IN INDUSTRY LA English DT Article DE AGRICULTURE; SIMULATION; SAWMILL; FORESTRY; COMPUTER APPLICATIONS; MANAGEMENT SUPPORT; SPREADSHEET; LOTUS 1-2-3 ID LOG BUCKING; ALLOCATION AB Spreadsheet and simulation models are tools which enable users to analyze a large number of variables affecting harwood material utilization and profit in a systematic fashion. This paper describes two spreadsheet models, SEASaw and SEAIn, and a hardwood sawmill simulator. SEASaw is designed to estimate the amount of conversion from timber to lumber, while SEAIn is a log inventory module. The two spreadsheet modules are currently being interfaced and linked to an integrated system which will be optimized under the same spreadsheet environment. The simulator has the capability to describe in real time, the system performance of a hardwood sawmill under any specified operating conditions. C1 UNIV ILLINOIS,DEPT FORESTRY,URBANA,IL 61801. USA,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL. SE FOREST EXPT STN,BLACKSBURG,VA. NE FOREST EXPT STN,PRINCETON,WV. NR 28 TC 3 Z9 4 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3615 J9 COMPUT IND JI Comput. Ind. PD AUG PY 1991 VL 16 IS 4 BP 343 EP 351 DI 10.1016/0166-3615(91)90074-J PG 9 WC Computer Science, Interdisciplinary Applications SC Computer Science GA GC031 UT WOS:A1991GC03100003 ER PT J AU WEINSTEIN, SA LAFAYE, PJ SMITH, LA AF WEINSTEIN, SA LAFAYE, PJ SMITH, LA TI OBSERVATIONS ON A VENOM NEUTRALIZING FRACTION ISOLATED FROM SERUM OF THE NORTHERN COPPERHEAD, AGKISTRODON-CONTORTRIX-MOKASEN SO COPEIA LA English DT Article ID ANTIHEMORRHAGIC FACTOR; SNAKE-VENOMS; PURIFICATION; PLASMA AB Venom neutralizing capacity of serum from the northern copperhead, Agkistrodon contortrix mokasen, was studied. Crude serum neutralized the hemorrhagic, proteolytic, and lethal activity of A. c. mokasen venom. The serum neutralized up to 2.5 LD50 of A. c. mokasen venom and up to 5 LD50 of A. piscivorus conanti venom. The serum was antihemorrhagic and a potent inhibitor of venom proteases and trypsin. A fraction was isolated from A. c. mokasen serum by DEAE-Affi-Gel Blue chromatography and Superose-12 (molecular sieve) fast protein liquid chromatography with recycling. This fraction contained two major proteins with apparent molecular weights of 62 kD and 79 kD. The fraction had a pl of 4.6-4.7, displayed anodal migration in horizontal electrophoresis, and exhibited the venom neutralization capacity of the crude serum but did not inhibit venom proteases or trypsin. In amounts of only 16.5-mu-g, it protected against hemorrhage induced by up to 100-mu-g of A. c. mokasen venom. RP WEINSTEIN, SA (reprint author), USA, MED RES INST INFECT DIS, DEPT TOXINOL, DIV PATHOL, FREDERICK, MD 21701 USA. NR 33 TC 10 Z9 11 U1 0 U2 1 PU AMER SOC ICHTHYOLOGISTS & HERPETOLOGISTS PI MIAMI PA MAUREEN DONNELLY, SECRETARY FLORIDA INT UNIV BIOLOGICAL SCIENCES, 11200 SW 8TH STREET, MIAMI, FL 33199 USA SN 0045-8511 EI 1938-5110 J9 COPEIA JI Copeia PD AUG 1 PY 1991 IS 3 BP 777 EP 786 PG 10 WC Zoology SC Zoology GA FZ812 UT WOS:A1991FZ81200021 ER PT J AU JABBARI, B VANNOSTRAND, D GUNDERSON, CH BARTOSZEK, D MITCHELL, MH LOMBARDO, M CITRIN, C SHERMAN, J AF JABBARI, B VANNOSTRAND, D GUNDERSON, CH BARTOSZEK, D MITCHELL, MH LOMBARDO, M CITRIN, C SHERMAN, J TI EEG AND NEUROIMAGING LOCALIZATION IN PARTIAL EPILEPSY SO ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY LA English DT Article DE EEG; NEUROIMAGING LOCALIZATION; PARTIAL EPILEPSY; COMPUTED TOMOGRAPHY; MAGNETIC RESONANCE IMAGING; SINGLE PHOTON EMISSION TOMOGRAPHY ID COMPLEX PARTIAL SEIZURES; FOCAL EPILEPSY; COMPUTED-TOMOGRAPHY; INITIAL EXPERIENCE; SPECT; ELECTROENCEPHALOGRAPHY; CT AB We have studied cortical localization provided by surface and sphenoidal electroencephalograms (EEGs) and that of computed tomography (CT), magnetic resonance imaging (MR) and single photon emission tomography (SPECT) in 58 patients with partial epilepsy. Each patient had EEG, MR and SPECT during a hospitalization period of 1-2 weeks. CT scans were obtained either during the same period or had been performed in the preceding year. EEG evaluation consisted of 3-5 days of continuous monitoring including video-telemetry and ambulatory recording as well as conventional EEGs with special electrode placements. Additionally 33 of 58 patients (55%) who were potential surgical candidates had sphenoidal recordings. All patients had an abnormal EEG which showed evidence of epileptic hyperexcitability. EEG abnormality was localized in 43 patients (74%). Neuroimaging studies were focally abnormal in 38 patients (66%); 12 CT (21%), 29 MR (50%) and 24 SPECT (41%). Thirty four of 43 patients with localized EEG had at least 1 focally abnormal neuroimaging study (79%), whereas 4 of 15 (27%) patients with non-localized EEG did so. Twenty-eight of 29 patients with focal MR (97%), 11 of 12 patients with focal CT (92%) and 20 of 24 patients with focal SPECT (83%) had a concordant focal EEG. EEG and neuroimaging localization agreed in all 15 patients in whom both MR and SPECT disclosed a concordant focal abnormality. This study demonstrates a significant (P < 0.005) correlation between surface/sphenoid EEG and neuroimaging localization in partial epilepsy. C1 WALTER REED ARMY MED CTR,DEPT RADIOL,NUCL MED SECT,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. MAGNET IMAGING WASHINGTON,WASHINGTON,DC. RP JABBARI, B (reprint author), WALTER REED ARMY MED CTR,NEUROL SERV,WASHINGTON,DC 20307, USA. NR 32 TC 21 Z9 21 U1 0 U2 0 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0013-4694 J9 ELECTROEN CLIN NEURO JI Electroencephalogr. Clin. Neurophysiol. PD AUG PY 1991 VL 79 IS 2 BP 108 EP 113 DI 10.1016/0013-4694(91)90047-8 PG 6 WC Engineering, Biomedical; Clinical Neurology SC Engineering; Neurosciences & Neurology GA GA578 UT WOS:A1991GA57800005 PM 1713823 ER PT J AU PATTON, JF KASZUBA, J MELLO, RP REYNOLDS, KL AF PATTON, JF KASZUBA, J MELLO, RP REYNOLDS, KL TI PHYSIOLOGICAL-RESPONSES TO PROLONGED TREADMILL WALKING WITH EXTERNAL LOADS SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY LA English DT Article DE ENERGY COST; LOAD CARRIAGE; PREDICTION EQUATION ID ENERGY COST; EXERCISE; DETERMINANTS; CONSUMPTION; EXPENDITURE; MEN AB Limited information is available regarding the physiological responses to prolonged load carriage. This study determined the energy cost of prolonged treadmill walking (fixed distance of 12 km) at speeds of 1.10 m.s-1, 1.35 m.s-1, and 1.60 m.s-1, unloaded (clothing mass 5.2 kg) and with external loads of 31.5 and 49.4 kg. Fifteen male subjects performed nine trials in random order over a 6-week period. Oxygen uptake (VO2) was determined at the end of the first 10 min and every 20 min thereafter. A 10-min rest period was allowed following each 50 min of walking. No changes occurred in VO2 over time in the unloaded condition at any speed. The 31.5 and 49.4 kg loads, however, produced significant increases (ranging from 10 to 18%) at the two fastest and at all three speeds, respectively, even at initial exercise intensities less than 30% VO2max. In addition, the 49.4 kg load elicited a significantly higher (P < 0.05) VO2 than did the 31.5 kg load at all speeds. The measured values of metabolic cost were also compared to those predicted using the formula of Pandolf et al. In trials where VO2 increased significantly over time, predicted values underestimated the actual metabolic cost during the final minute by 10-16%. It is concluded that energy cost during prolonged load carriage is not constant but increases significantly over time even at low relative exercise intensities. It is further concluded that applying the prediction model which estimates energy expenditure from short-term load carriage efforts to prolonged load carriage can result in significant underestimations of the actual energy cost. RP PATTON, JF (reprint author), USA,ENVIRONM MED RES INST,DIV OCCUPAT PHYSIOL,NATICK,MA 01760, USA. NR 29 TC 41 Z9 42 U1 2 U2 11 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0301-5548 J9 EUR J APPL PHYSIOL O JI Eur. J. Appl. Physiol. Occup. Physiol. PD AUG PY 1991 VL 63 IS 2 BP 89 EP 93 DI 10.1007/BF00235175 PG 5 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA GD644 UT WOS:A1991GD64400003 PM 1748110 ER PT J AU SAYLES, AH UYEMURA, JP AF SAYLES, AH UYEMURA, JP TI AN OPTOELECTRONIC CMOS MEMORY CIRCUIT FOR PARALLEL DETECTION AND STORAGE OF OPTICAL-DATA SO IEEE JOURNAL OF SOLID-STATE CIRCUITS LA English DT Article ID LOGIC AB A CMOS static RAM circuit capable of detecting and storing optically transmitted data is described. Bits of data are transferred to the memory circuit via an array of parallel light beams. A 16-b optoelectronic SRAM has been fabricated in a standard bulk CMOS process and tested using argon and helium-neon lasers. Data contained in an array of 16 light beams with an average power of 3.35-mu-W/pixel were successfully transferred to the SRAM in parallel fashion. The storage of the optical information was verified by electrically addressing each cell. The optical data transfer technology is extended to other systems in which high speed and parallelism are essential. C1 GEORGIA INST TECHNOL,SCH ELECT ENGN,ATLANTA,GA 30332. RP SAYLES, AH (reprint author), US MIL ACAD,USA PHOTON RES CTR,W POINT,NY 10996, USA. NR 12 TC 11 Z9 11 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9200 J9 IEEE J SOLID-ST CIRC JI IEEE J. Solid-State Circuit PD AUG PY 1991 VL 26 IS 8 BP 1110 EP 1115 DI 10.1109/4.90064 PG 6 WC Engineering, Electrical & Electronic SC Engineering GA FW510 UT WOS:A1991FW51000006 ER PT J AU MELACHRINOUDIS, E RICE, K AF MELACHRINOUDIS, E RICE, K TI THE PRIORITIZATION OF TECHNOLOGIES IN A RESEARCH LABORATORY SO IEEE TRANSACTIONS ON ENGINEERING MANAGEMENT LA English DT Article ID ANALYTIC HIERARCHY PROCESS; PROJECT SELECTION AB This paper considers the prioritization of technologies at the Army Materials Technology Laboratory. The authors have worked with the management of the laboratory in identifying the criteria and the technologies to be evaluated. A mathematical model was developed to combine the subjective criteria with a single objective criterion. The three divisions of the laboratory and a technical working group of the Army Materiel Command provided the input data for the model. The criteria weights were determined by the Analytic Hierarchy Process through a hierarchical representation and pairwise comparisons. The results from the three divisions were aggregated to yield a prioritized list of technologies to be used by the management of the laboratory for funding decisions of projects within technology areas. C1 USA,NATICK LABS,NATICK,MA 01760. RP MELACHRINOUDIS, E (reprint author), NORTHEASTERN UNIV,DEPT IND ENGN & INFORMAT SYST,BOSTON,MA 02115, USA. NR 20 TC 14 Z9 14 U1 1 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9391 J9 IEEE T ENG MANAGE JI IEEE Trans. Eng. Manage. PD AUG PY 1991 VL 38 IS 3 BP 269 EP 278 DI 10.1109/17.83759 PG 10 WC Business; Engineering, Industrial; Management SC Business & Economics; Engineering GA FV888 UT WOS:A1991FV88800008 ER PT J AU NAIR, VK LUDWIG, R ANASTASI, RF AF NAIR, VK LUDWIG, R ANASTASI, RF TI THE CHIRP-Z TRANSFORM APPLIED TO ADHESIVELY BONDED STRUCTURES SO IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT LA English DT Article AB A signal-processing technique based on the Chirp-Z transform is presented to evaluate the echo signals of longitudinal ultrasonic transducers in contact with bonded materials. Both a simulated glass-glass interface of variable thickness and a realistic double lap bonded aluminum sample were tested. The observed frequency dips and peaks in the transducer spectrum from pulse-echo and through-transmission modes were recorded and related to the condition of zero reflection coefficient at the interfacial layer. Resulting thickness predictions for different transducer center frequencies ranging from 5-20 MHz are in excellent agreement with experimental measurements. C1 USA,MAT TECHNOL LAB,WATERTOWN,MA 02172. RP NAIR, VK (reprint author), WORCESTER POLYTECH INST,DEPT ELECT ENGN,WORCESTER,MA 01609, USA. NR 12 TC 7 Z9 7 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9456 J9 IEEE T INSTRUM MEAS JI IEEE Trans. Instrum. Meas. PD AUG PY 1991 VL 40 IS 4 BP 751 EP 758 DI 10.1109/19.85347 PG 8 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA GB246 UT WOS:A1991GB24600016 ER PT J AU BARSOUM, RS CHEN, TK AF BARSOUM, RS CHEN, TK TI 3-DIMENSIONAL SURFACE SINGULARITY OF AN INTERFACE CRACK SO INTERNATIONAL JOURNAL OF FRACTURE LA English DT Article ID ELASTIC PLATE; STRESS; INTERSECTION; STATE AB The three-dimensional singularity field near the terminal point of an interface crack at the free surface of an elastic bimaterial is investigated. The Finite Element Iterative Method (FEIM) is used for evaluating the asymptotic field. A spherical coordinate system r, theta, phi is used and the singular displacement field is assumed to be of a product form r-lambda g(theta, phi), where lambda and g(.) are in general complex. To validate the model, the method is first applied to the three dimensional surface crack in a homogeneous elastic material. The results for this case show excellent agreement with previously published analytical and numerical results. For an extreme effect of bimaterial property mismatch, on the surface crack singularity, an elastic material bonded to a rigid substrate is investigated (E1/E2 = infinity). The results show that the complex power singularity depends strongly on Poisson's ratio nu. The real part of the stress singularity is greater than 0.5 of the plane strain case and the imaginary part becomes almost zero at nu greater-than-or-equal-to 0.25 instead of at nu = 0.5. The second term in the expansion of the asymptotic field was shown to have a singularity of 0.5. C1 USA,MAT TECHNOL LAB,WATERTOWN,MA 02172. NR 31 TC 27 Z9 27 U1 2 U2 2 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0376-9429 J9 INT J FRACTURE JI Int. J. Fract. PD AUG 1 PY 1991 VL 50 IS 3 BP 221 EP 237 DI 10.1007/BF00032158 PG 17 WC Materials Science, Multidisciplinary; Mechanics SC Materials Science; Mechanics GA GL217 UT WOS:A1991GL21700004 ER PT J AU SINGH, VP KRISHNA, S MORTON, DC AF SINGH, VP KRISHNA, S MORTON, DC TI ELECTRIC-FIELD AND CONDUCTION CURRENT IN AC THIN-FILM ELECTROLUMINESCENT DISPLAY DEVICES SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID SIMPLE-MODEL; EXCITATION; BEHAVIOR; CHARGE; EU AB Current flow through the phosphor layer of ac thin film electroluminescent display devices has been analyzed. It is shown that the traditional capacitive bridge technique for measuring the time dependence of phosphor conduction current [i(LP)(t)] can yield inaccurate results, especially when the multiplication factor of [(C(I) + C(p)/C(I)] is not used, and the phosphor layer has bulk space charge; C(I) and C(p) are insulator and phosphor layer capacitances, respectively. A new method for the measurement of i(LP)(t) has been developed. It is more accurate and is applicable even when the bulk charge in the phosphor layer is not negligible. The new method was applied to the study of ZnS:Mn ac thin-film electroluminescent (ACTFEL) devices excited by voltage pulses of three different slew rates. i(LP)(t) measured by the new method was compared against the bridge current (i(bridge)). Electric field and displacement current in the phosphor were calculated. Transferred charge computed by integrating i(LP) and i(bridge) over half cycle was compared against the polarization charge obtained from the Q-V curve of the device. C1 USA,LABCOM,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. RP SINGH, VP (reprint author), UNIV TEXAS,DEPT ELECT ENGN,EL PASO,TX 79968, USA. NR 19 TC 17 Z9 17 U1 1 U2 3 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD AUG 1 PY 1991 VL 70 IS 3 BP 1811 EP 1819 DI 10.1063/1.349497 PG 9 WC Physics, Applied SC Physics GA GA100 UT WOS:A1991GA10000103 ER PT J AU PRUSACZYK, WK SAWKA, MN AF PRUSACZYK, WK SAWKA, MN TI EFFECTS OF PYRIDOSTIGMINE BROMIDE ON HUMAN THERMOREGULATION DURING COLD WATER IMMERSION SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE ANTICHOLINESTERASE; COLD STRESS; HYPOTHERMIA ID EXERCISE; BLOOD AB This study examined the effects of an oral 30-mg dose of pyridostigmine bromide (PYR) on thermoregulatory and physiological responses of men undergoing cold stress. Six men were immersed in cold water (20-degrees-C) for up to 180 min on two occasions, once each 2 h after ingestion of PYR and 2 h after ingestion of a placebo. With PYR, erythrocyte cholinesterase inhibition was 33 +/- 12% (SD) 110 min postingestion (10 min preimmersion) and 30 +/- 7% at termination of exposure (mean 117 min). Percent cholinesterase inhibition was significantly related to lean body mass (r = -0.91, P < 0.01). Abdominal discomfort caused termination in three of six PYR experiments but in none of the control experiments (mean exposure time 142 min). During immersion, metabolic rate, ventilatory volume, and respiratory rate increased significantly (P < 0.05) over preimmersion levels and metabolic rate increased with duration of immersion (P < 0.01) in both treatments but did not differ between conditions. PYR had no significant effect on rectal temperature, mean body temperature, thermal sensations, heart rate, plasma cortisol, or change in plasma volume. It was concluded that a 30-mg dose of PYR does not increase an individual's susceptibility to hypothermia during cold water immersion; however, in combination with cold stress, PYR may result in marked abdominal cramping and limit cold tolerance. C1 USA,ENVIRONM MED RES INST,DIV THERMAL PHYSIOL & MED,KANSAS ST,NATICK,MA 01760. NR 28 TC 3 Z9 3 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD AUG PY 1991 VL 71 IS 2 BP 432 EP 437 PG 6 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA GA420 UT WOS:A1991GA42000008 PM 1938714 ER PT J AU HOYT, RW DURKOT, MJ FORTE, VA HUBBARD, LJ TRAD, LA CYMERMAN, A AF HOYT, RW DURKOT, MJ FORTE, VA HUBBARD, LJ TRAD, LA CYMERMAN, A TI HYPOBARIC HYPOXIA (380-TORR) DECREASES INTRACELLULAR AND TOTAL-BODY WATER IN GOATS SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE HIGH ALTITUDE; CELL WATER; EXTRACELLULAR FLUID; PLASMA VOLUME ID HIGH-ALTITUDE EXPOSURE; PLASMA-VOLUME; FLUID; STRESS AB The effects of prolonged hypoxia on body water distribution was studied in four unanesthetized adult goats (Capra lircus) at sea level and after 16 days in a hypobaric chamber [(380 Torr, 5,500 m, 24 +/- 1-degree-C); arterial PO2 = 27 +/- 2 (SE) Torr]. Total body water (TBW), extracellular fluid volume (ECF), and plasma volume (PV) were determined with (H2O)-H-3, [C-14]inulin, and indocyanine green dye, respectively. Blood volume (BV) [BV = 100PV/(100 - hematocrit)], erythrocyte volume (RCV) (RCV = BV - PV), and intracellular fluid (ICF) (ICF = TBW - ECF) and interstitial fluid (ISF) (ISF = ECF - PV) volumes were calculated. Hypoxia resulted in increased pulmonary ventilation and arterial pH and decreased arterial PCO2 and PO2 (P < 0.05). In addition, body mass (-7.1%), TBW (-9.1%), and ICF volume (-14.4%) all decreased, whereas ECF (+11.7%) and ISF (+27.7%) volumes increased (P < 0.05). The decrease in TBW accounted for 89% of the loss of body mass. Although PV decreased significantly (-15.3%), BV was unchanged because of an offsetting increase in RCV (+39.5%; P < 0.05). We conclude that, in adult goats, prolonged hypobaric hypoxia results in decreases in TBW volume, ICF volume, and PV, with concomitant increases in ECF and ISF volumes. RP HOYT, RW (reprint author), USA,ENVIRONM MED RES INST,DIV ALTITUDE PHYSIOL & MED,NATICK,MA 01760, USA. NR 22 TC 6 Z9 6 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD AUG PY 1991 VL 71 IS 2 BP 509 EP 513 PG 5 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA GA420 UT WOS:A1991GA42000018 PM 1938722 ER PT J AU COSTAS, FL WONG, M AF COSTAS, FL WONG, M TI INTRACORONAL ISOLATING BARRIERS - EFFECT OF LOCATION ON ROOT LEAKAGE AND EFFECTIVENESS OF BLEACHING AGENTS SO JOURNAL OF ENDODONTICS LA English DT Article ID CERVICAL RESORPTION; TEETH AB The purpose of this study was to evaluate the ability of several intracoronal isolating barrier materials to prevent leakage of a bleaching agent into the roots of teeth and to determine whether placement of the barrier material at the cementoenamel junction or below the cementoenamel junction has an effect on the bleaching results of the crowns. Fifty teeth were stained in vitro, and gutta-percha fillings were placed in the root canals. The experimental isolating barriers were placed at the cementoenamel junction or 2 mm below the cementoenamel junction. A walking bleach of Superoxol and sodium perborate was placed in the pulp chamber for three treatments. The roots of the teeth were evaluated for the presence of root decoloration, and the crowns of the teeth were evaluated for bleaching effect. Findings from this study showed a significant difference between gutta-percha alone and gutta-percha with barrier in preventing root decoloration (p < 0.05). No significant differences were found between the other experimental groups in preventing root decoloration. Placement of an intracoronal isolating barrier material 2 mm below the cementoenamel junction resulted in a more acceptable esthetic bleaching result of the crowns than did placement of barrier material at the cementoenamel junction. C1 USA,DENT ACTIVITIES,FT HOOD,TX 76544. USA,DENT ACTIVITIES,FT GORDON,GA 30905. NR 16 TC 18 Z9 18 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD AUG PY 1991 VL 17 IS 8 BP 365 EP 368 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA FZ185 UT WOS:A1991FZ18500002 PM 1809798 ER PT J AU BAUMGARTNER, JC FALKLER, WA AF BAUMGARTNER, JC FALKLER, WA TI BACTERIA IN THE APICAL 5 MM OF INFECTED ROOT CANALS SO JOURNAL OF ENDODONTICS LA English DT Article ID BLACK-PIGMENTED BACTEROIDES; ANAEROBIC-BACTERIA; ENDODONTALIS; SYMPTOMS; TEETH AB Ten freshly extracted teeth which had carious pulpal exposures and periapical lesions contiguous with the root apex were placed inside an anaerobic chamber and the apical 5 mm of the root canals cultured. In addition to anaerobic incubation, duplicate cultures were incubated aerobically. Fifty strains of bacteria from the 10 root canals were isolated and identified. The most prominent bacteria cultured from the 10 root canals were Actinomyces, Lactobacillus, black-pigmented Bacteroides, Peptostreptococcus, nonpigmented Bacteroides, Veillonella, Enterococcus faecalis, Fusobacterium nucleatum, and Streptococcus mutans. Of the 50 bacterial isolates, 34 (68%) were strict anaerobes. This study demonstrates the presence of predominately anaerobic bacteria in the apical 5 mm of infected root canals in teeth with carious pulpal exposures and periapical lesions. C1 WALTER REED ARMY MED CTR,INST DENT RES,WASHINGTON,DC 20307. UNIV MARYLAND,SCH DENT,DEPT MICROBIOL,BALTIMORE,MD 21201. NR 20 TC 141 Z9 150 U1 0 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD AUG PY 1991 VL 17 IS 8 BP 380 EP 383 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA FZ185 UT WOS:A1991FZ18500007 PM 1809801 ER PT J AU STOCKSTILL, RL NEILSON, FM ZITTA, VL AF STOCKSTILL, RL NEILSON, FM ZITTA, VL TI HYDRAULIC CALCULATIONS FOR FLOW IN LOCK MANIFOLDS SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Article AB A procedure to calculate the flow and pressure distributions within navigation-lock manifolds is presented. The approach is to treat each port as a discrete element in the flow system. Values of port hydraulic coefficients are established using previously reported laboratory studies of the flow characteristics of single-port manifolds. Energy-loss equations are written for the flow path through each port in the manifold. These equations use the port coefficients determined from laboratory experiments and the Darcy-Weisbach friction factor. The energy-loss equations are used in conjunction with the continuity equation to form a system of nonlinear equations in which the unknowns are the manifold discharges. These equations are solved simultaneously using a predictor-corrector numerical scheme to provide a solution to multiported manifolds. The solution technique is verified with model data for manifold designs in existing locks. The solution technique determines the culvert and port discharges and the pressure distributions for these manifolds within acceptable limits. C1 MISSISSIPPI STATE UNIV,DEPT CIVIL ENGN,MISSISSIPPI STATE,MS 39762. RP STOCKSTILL, RL (reprint author), USA,WATERWAYS EXPT STN,CEWES HS-L,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 24 TC 2 Z9 3 U1 0 U2 2 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD AUG PY 1991 VL 117 IS 8 BP 1026 EP 1041 DI 10.1061/(ASCE)0733-9429(1991)117:8(1026) PG 16 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA FY167 UT WOS:A1991FY16700005 ER PT J AU MARKOFF, LJ INNIS, BL HOUGHTEN, R HENCHAL, LS AF MARKOFF, LJ INNIS, BL HOUGHTEN, R HENCHAL, LS TI DEVELOPMENT OF CROSS-REACTIVE ANTIBODIES TO PLASMINOGEN DURING THE IMMUNE-RESPONSE TO DENGUE VIRUS-INFECTION SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID PARTIAL NUCLEOTIDE-SEQUENCE; JAPANESE ENCEPHALITIS-VIRUS; YELLOW-FEVER VIRUS; STRUCTURAL PROTEINS; ACTIVATOR GENE; GENOME; ACID; RNA; CHAIN AB The four serotypes of dengue virus (a mosquito-borne flavivirus) cause an acute febrile illness (dengue fever) or a more prolonged illness with plasma leakage resulting in hypovolemia (dengue hemorrhagic fever). Hemorrhage may accompany either. Epidemiologic data suggest a role for dengue antibodies in pathogenesis. Computer analysis revealed a 20-residue region of similarity in amino acid sequence between the dengue type 4 envelope glycoprotein (E) and a family of clotting factors, including plasminogen, the prime mediator of fibrinolysis. By use of synthetic peptides in ELISA, E antibodies that potentially bind plasminogen were detected in 75% of 40 Thai patients acutely infected with dengue virus type 1, 2, 3, or 4. Plasminogen cross-reactivity of dengue antibodies was shown to be specific for the related sites in E and plasminogen. The dengue E sequence with similarity to plasminogen is largely conserved within the currently known flavivirus E sequences. However, 15 Thai patients hospitalized for illness caused by Japanese encephalitis virus (a flavivirus not associated with hemorrhage) did not develop plasminogen-cross-reactive antibodies, and this finding correlated with failure of Japanese encephalitis virus antibodies to bind to the plasminogen-cross-reactive site in E. C1 ARMED FORCES RES INST MED SCI,DEPT VIROL,BANGKOK,THAILAND. TORREY PINES INST MOLEC STUDIES,SAN DIEGO,CA. RP MARKOFF, LJ (reprint author), NIAID,INFECT DIS LAB,BLDG 7,ROOM 230,9000 ROCKVILLE PIKE,BETHESDA,MD 20892, USA. NR 45 TC 44 Z9 49 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD AUG PY 1991 VL 164 IS 2 BP 294 EP 301 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA FY100 UT WOS:A1991FY10000010 PM 1856477 ER PT J AU LAL, RB RUDOLPH, DL ROBERTS, C HONDA, M AF LAL, RB RUDOLPH, DL ROBERTS, C HONDA, M TI ELEVATED LEVELS OF SOLUBLE CD8 AND SOLUBLE CD25 IN PATIENTS WITH HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I-ASSOCIATED MYELOPATHY AND ADULT T-CELL LEUKEMIA SO JOURNAL OF INFECTIOUS DISEASES LA English DT Letter ID HTLV-I C1 WALTER REED ARMY MED CTR,DIV RETROVIROL,ROCKVILLE,MD. NATL INST HLTH,AIDS RES CTR,TOKYO 141,JAPAN. RP LAL, RB (reprint author), CTR DIS CONTROL,DIV VIRAL & RICKETTSIAL DIS,RETROVIRUS DIS BRANCH,MAIL STOP G-19,ATLANTA,GA 30333, USA. NR 10 TC 5 Z9 5 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD AUG PY 1991 VL 164 IS 2 BP 429 EP 430 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA FY100 UT WOS:A1991FY10000036 PM 1906914 ER PT J AU MILLS, JN ELLIS, BA MCKEE, KT MAIZTEGUI, JI CHILDS, JE AF MILLS, JN ELLIS, BA MCKEE, KT MAIZTEGUI, JI CHILDS, JE TI HABITAT ASSOCIATIONS AND RELATIVE DENSITIES OF RODENT POPULATIONS IN CULTIVATED AREAS OF CENTRAL ARGENTINA SO JOURNAL OF MAMMALOGY LA English DT Article ID HEMORRHAGIC-FEVER; ENDEMIC AREA AB Small mammals were livetrapped during 12 months in crop fields and weedy borders at 18 sites in central Argentina. A total of 1,652 mammals of 14 species was captured during 33,060 trap-nights. Six species of rodents comprised > 95% of captures. Periodically disturbed fields of crops were dominated by Calomys musculinus and C. laucha, and to a lesser extent Mus musculus. A second group composed of Akodon azarae, Bolomys obscurus, and Oligoryzomys flavescens primarily inhabited the more stable, weedy borders of cultivated fields. Peaks in relative densities of C. musculinus, C. laucha, and M. musculus were observed in summer and early autumn, and populations declined to low numbers in winter, following harvest. In contrast, maxima for A. azarae, B. obscurus, and O. flavescens were in late autumn and early winter, and numbers never declined to low values seen for the other species. These characteristic differences in habitat associations and relative densities of pampas rodents may reflect colonizing potential, as both Calomys and Mus potentially are highly opportunistic genera. C1 USA,MED RES INST INFECT DIS,DIV MED,FREDERICK,MD 21701. INST NACL ESTUDIOS SOBRE VIROSIS HEMORRAGICAS,RA-2700 PERGAMINO,BUENOS AIRES,ARGENTINA. RP MILLS, JN (reprint author), JOHNS HOPKINS UNIV,DEPT IMMUNOL & INFECT DIS,BALTIMORE,MD 21205, USA. RI Childs, James/B-4002-2012 NR 33 TC 105 Z9 117 U1 0 U2 3 PU AMER SOC MAMMALOGISTS PI PROVO PA BRIGHAM YOUNG UNIV, DEPT OF ZOOLOGY, PROVO, UT 84602 SN 0022-2372 J9 J MAMMAL JI J. Mammal. PD AUG PY 1991 VL 72 IS 3 BP 470 EP 479 DI 10.2307/1382129 PG 10 WC Zoology SC Zoology GA GB706 UT WOS:A1991GB70600004 ER PT J AU TRAUTMANN, M GHANDCHI, A HELD, T CRYZ, SJ CROSS, AS AF TRAUTMANN, M GHANDCHI, A HELD, T CRYZ, SJ CROSS, AS TI AN ENZYME-LINKED-IMMUNOSORBENT-ASSAY FOR THE DETECTION OF SOLUBLE KLEBSIELLA-PNEUMONIAE CAPSULAR POLYSACCHARIDE SO JOURNAL OF MICROBIOLOGICAL METHODS LA English DT Article DE CAPSULE; ELISA; KLEBSIELLA-PNEUMONIAE; POLYSACCHARIDE ID EXTRACELLULAR TOXIC COMPLEX; SODIUM-SALICYLATE; PURIFICATION; CEFTAZIDIME; VIRULENCE; REDUCTION; RATS AB Extracellular capsular polysaccharide (CPS) produced by Klebsiella pneumoniae capsular type 2 was quantitated by means of an enzyme-linked immunosorbent assay. Microtiter plates were coated with a CPS-specific mouse monoclonal antibody which served to capture CPS present in culture supernatants and biological fluids. A polyclonal rabbit IgG preparation with high antibody content against CPS type 2 was added as a secondary antibody, and bound rabbit IgG was visualized by the addition of alkaline-phosphatase-conjugated anti-rabbit-IgG. Simultaneous testing of standards of purified CPS type 2 permitted the quantitation of CPS in samples of culture fluid, mouse and human plasma, and human urine. Due to its high sensitivity with a lower limit of detectability of 1 ng.ml-1 of CPS, the test system may prove superior to standard chemical methods of CPS quantification. C1 SWISS SERUM & VACCINE INST,BERN,SWITZERLAND. WALTER REED ARMY MED CTR,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. RP TRAUTMANN, M (reprint author), FREE UNIV BERLIN,KLINIKUM RUDOLF VIRCHOW,DIV INFECT DIS,AUGUSTENBURGER PL 1,W-1000 BERLIN 65,GERMANY. NR 27 TC 8 Z9 8 U1 1 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-7012 J9 J MICROBIOL METH JI J. Microbiol. Methods PD AUG PY 1991 VL 13 IS 4 BP 305 EP 313 DI 10.1016/0167-7012(91)90068-2 PG 9 WC Biochemical Research Methods; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA GE476 UT WOS:A1991GE47600008 ER PT J AU MURPHY, TP AF MURPHY, TP TI OTOLOGIC MANIFESTATIONS OF PSEUDOTUMOR CEREBRI SO JOURNAL OF OTOLARYNGOLOGY LA English DT Article AB Otologic manifestations of pseudotumor cerebri heightened awareness of pseudotumor cerebri and its varied subtle presentations will allow for a more expedient diagnosis by the otolaryngologist. Pseudotumor cerebri is defined as increased intracranial pressure and papilledema without a mass lesion or obstruction of the ventricular system. Presenting symptoms most commonly are headache and visual dysfunction. However, patients may present with associated symptoms of tinnitus, dizziness and hearing loss. These patients may be seen first by the otolaryngologist. Fourteen patients with a diagnosis of pseudotumor cerebri are reviewed. Nine of the 14 patients had neurotologic symptoms during the course of their evaluation. Pseudotumor cerebri is a diagnostic challenge. Keys to diagnosis are a high index of suspicion, careful history and funduscopic examination in patients with unexplained neuro-otologic symptoms. C1 BROOKE ARMY MED CTR,DEPT OTOLARYNGOL,FT SAM HOUSTON,TX 78234. NR 0 TC 12 Z9 12 U1 0 U2 1 PU DECKER PERIODICALS INC PI HAMILTON PA 4 HUGHSON STREET SOUTH PO BOX 620, LCD 1, HAMILTON ON L8N 3K7, CANADA SN 0381-6605 J9 J OTOLARYNGOL JI J. Otolaryngol. PD AUG PY 1991 VL 20 IS 4 BP 258 EP 261 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA GB220 UT WOS:A1991GB22000006 PM 1920579 ER PT J AU ROBIE, DK PEARL, RH GONSALES, C RESTUCCIA, RD HOFFMAN, MA AF ROBIE, DK PEARL, RH GONSALES, C RESTUCCIA, RD HOFFMAN, MA TI OPERATIVE STRATEGY FOR RECURRENT LARYNGEAL CLEFT - A CASE-REPORT AND REVIEW OF THE LITERATURE SO JOURNAL OF PEDIATRIC SURGERY LA English DT Article; Proceedings Paper CT 42ND ANNUAL MEETING OF THE SURGICAL SECTION OF THE AMERICAN ACADEMY OF PEDIATRICS CY OCT 06-07, 1990 CL BOSTON, MA SP AMER ACAD PEDIAT, SURG SECT DE LARYNGOTRACHEAL CLEFT; RECURRENT ID LARYNGOTRACHEOESOPHAGEAL CLEFT; MANAGEMENT; DIAGNOSIS; REPAIR C1 WALTER REED ARMY MED CTR,DEPT SURG,PEDIAT GEN SURG SERV,WASHINGTON,DC 20307. NR 28 TC 19 Z9 19 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0022-3468 J9 J PEDIATR SURG JI J. Pediatr. Surg. PD AUG PY 1991 VL 26 IS 8 BP 971 EP 974 DI 10.1016/0022-3468(91)90845-K PG 4 WC Pediatrics; Surgery SC Pediatrics; Surgery GA GA102 UT WOS:A1991GA10200016 PM 1919991 ER PT J AU WISWELL, TE CURTIS, J DOBEK, AS ZIERDT, CH AF WISWELL, TE CURTIS, J DOBEK, AS ZIERDT, CH TI STAPHYLOCOCCUS-AUREUS COLONIZATION AFTER NEONATAL CIRCUMCISION IN RELATION TO DEVICE USED SO JOURNAL OF PEDIATRICS LA English DT Article ID 1ST MONTH; CLAMP; LIFE C1 WALTER REED ARMY MED CTR, DEPT CLIN INVEST, WASHINGTON, DC 20307 USA. NIH, DEPT CLIN PATHOL, BETHESDA, MD 20892 USA. RP WISWELL, TE (reprint author), WALTER REED ARMY MED CTR, DEPT PEDIAT, NEONATOL SERV, WASHINGTON, DC 20307 USA. NR 15 TC 5 Z9 5 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 EI 1097-6833 J9 J PEDIATR-US JI J. Pediatr. PD AUG PY 1991 VL 119 IS 2 BP 302 EP 304 DI 10.1016/S0022-3476(05)80749-8 PG 3 WC Pediatrics SC Pediatrics GA FZ692 UT WOS:A1991FZ69200025 PM 1861220 ER PT J AU SANTARE, MH OTOOLE, BJ PATTON, EM AF SANTARE, MH OTOOLE, BJ PATTON, EM TI 2-DIMENSIONAL CRACK INCLUSION INTERACTION EFFECTS - ANALYSIS AND EXPERIMENTS SO JOURNAL OF PRESSURE VESSEL TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article ID STRESS-INTENSITY FACTORS; BIFURCATION AB The plane interaction between a crack and a rigid elliptical inclusion is investigated. In particular, the effects of the orientation and aspect ratio of the inclusion are considered. Analytically, the solution for the interaction of a dislocation with an inclusion is used as Green's function for the problem. The crack problem is then cast in the form of a set of integral equations with Cauchy singularities. These are solved numerically by the use of piecewise quadratic polynomials to approximate the unknown dislocation density along the crack. From this density the stress intensity at the crack tip can be determined. To model the situation experimentally photoelastic specimens with various elliptical inclusions are tested in uniaxial tension. The stress intensity factors are evaluated from the isochromatic fringe patterns and compared to those predicted numerically. C1 UNIV DELAWARE,CTR COMPOSITE MAT,NEWARK,DE 19716. UNIV DELAWARE,DEPT MECH ENGN,NEWARK,DE 19716. USA,BALLIST RES LAB,DIV INTERIOR BALLIST,ABERDEEN PROVING GROUND,MD 21005. RI Santare, Michael/B-1725-2008 NR 19 TC 1 Z9 1 U1 0 U2 1 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 0094-9930 J9 J PRESS VESS-T ASME JI J. Press. Vessel Technol.-Trans. ASME PD AUG PY 1991 VL 113 IS 3 BP 392 EP 397 DI 10.1115/1.2928772 PG 6 WC Engineering, Mechanical SC Engineering GA HP755 UT WOS:A1991HP75500007 ER PT J AU HANNON, SM AF HANNON, SM TI FACILITATED CEMENT REMOVAL BETWEEN SPLINTED PROVISIONAL RESTORATIONS SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Note RP HANNON, SM (reprint author), USA,LETTERMAN ARMY MED CTR,DEPT CLIN INVEST,SAN FRANCISCO,CA 94129, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD AUG PY 1991 VL 66 IS 2 BP 276 EP 276 DI 10.1016/S0022-3913(05)80063-0 PG 1 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA FZ335 UT WOS:A1991FZ33500027 PM 1774693 ER PT J AU CHRISTESEN, SD AF CHRISTESEN, SD TI VIBRATIONAL-SPECTRA AND ASSIGNMENTS OF DIETHYL SULFIDE, 2-CHLORODIETHYL SULFIDE AND 2,2'-DICHLORODIETHYL SULFIDE SO JOURNAL OF RAMAN SPECTROSCOPY LA English DT Article ID ROTATIONAL-ISOMERISM; CHAIN MOLECULES AB Raman and infrared (IR) spectra of diethyl sulfide (CH3CH2SCH2CH3), 2-chlorodiethyl sulfide (ClCH2CH2SCH2CH3), and 2,2'-dichlorodiethyl sulfide (mustard gas) (ClCH2CH2SCH2CH2Cl) were measured and their vibrational frequencies were compared to calculated frequencies reported by Sosa et al. The calculated frequencies were used to make probable assignments of the vibrational bands to normal modes of the molecules. Raman depolarization ratios for diethyl sulfide and 2-chlorodiethyl sulfide also aided in their vibrational assignments. Good agreement of the calculated frequencies with the experimental values was found except for the C-S and C-Cl stretching frequencies, which were consistently calculated to be lower than the experimentally found values. The experimental spectra also provide evidence for the presence of more than one stable molecular conformation in the liquid phase for each of the three sulfides. This has been observed for diethyl sulfide in previous studies. RP CHRISTESEN, SD (reprint author), USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010, USA. NR 5 TC 14 Z9 14 U1 1 U2 3 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0377-0486 J9 J RAMAN SPECTROSC JI J. Raman Spectrosc. PD AUG PY 1991 VL 22 IS 8 BP 459 EP 465 DI 10.1002/jrs.1250220807 PG 7 WC Spectroscopy SC Spectroscopy GA GC494 UT WOS:A1991GC49400006 ER PT J AU RICHARDS, KT BENFER, RH AF RICHARDS, KT BENFER, RH TI HOT ISOSTATIC PRESSING OF YBA2CU3O7-X SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Note DE HOT ISOSTATIC PRESSING; SUPERCONDUCTORS; TRANSITIONS; TEMPERATURE; OXYGEN ID SUPERCONDUCTING YBA2CU3O7; SYSTEM; PHASE; WATER AB Hot isostatic pressing (HIPing) with an oxygen donor was studied as a method for processing bulk superconductors. Superconducting powder was derived from the calcination of nitrated Y2O3, CuO, and BaCO3 powder. The powder was HIPed using pressures of 69, 138, and 207 MPa at 820-degrees-C. BaO2 was used as an oxygen donor during HIPing. The density, hardness, and Young's modulus of HIPed samples were higher than those of sintered control samples. Superconducting transition temperatures > 92 K were achieved without post-HIP annealing of the samples in oxygen. RP RICHARDS, KT (reprint author), USA,MAT TECHNOL LAB,CERAM RES BRANCH,WATERTOWN,MA 02172, USA. NR 16 TC 3 Z9 3 U1 2 U2 2 PU AMER CERAMIC SOC PI WESTERVILLE PA 735 CERAMIC PLACE, PO BOX 6136, WESTERVILLE, OH 43081-6136 SN 0002-7820 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD AUG PY 1991 VL 74 IS 8 BP 2014 EP 2017 DI 10.1111/j.1151-2916.1991.tb07826.x PG 4 WC Materials Science, Ceramics SC Materials Science GA GC006 UT WOS:A1991GC00600039 ER PT J AU MERRILL, BR AF MERRILL, BR TI EQUIVALENCE OF 2 THEORIES OF BEAM TILT SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION LA English DT Article ID CENTROID ANISOPLANATISM; TURBULENCE AB I demonstrate the equivalence of two different problems of beam tilt or angle of arrival. One approach employs the optical analog of the Ehrenfest theorem from quantum physics to derive the angle of arrival for a beam wave. The other approach models the tilt based on the average angle of arrival over a telescope aperature. RP MERRILL, BR (reprint author), USA,ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88001, USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0740-3232 J9 J OPT SOC AM A JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis. PD AUG PY 1991 VL 8 IS 8 BP 1316 EP 1318 DI 10.1364/JOSAA.8.001316 PG 3 WC Optics SC Optics GA FY419 UT WOS:A1991FY41900014 ER PT J AU SKOOG, SJ EVANS, CP HAYWARD, IJ GRIFFIN, JL HITCHCOCK, CL AF SKOOG, SJ EVANS, CP HAYWARD, IJ GRIFFIN, JL HITCHCOCK, CL TI FLOW-CYTOMETRY OF FINE NEEDLE ASPIRATIONS OF THE SPRAGUE-DAWLEY RAT TESTIS - DEFINING NORMAL MATURATION AND THE EFFECTS OF MULTIPLE BIOPSIES SO JOURNAL OF UROLOGY LA English DT Article; Proceedings Paper CT 1990 ANNUAL MEETING OF THE SECTION OF UROLOGY OF THE AMERICAN ACADEMY OF PEDIATRICS CY OCT 05-10, 1990 CL BOSTON, MA SP AMER ACAD PEDIAT, SECT UROL DE TESTIS; FLOW CYTOMETRY; SPERMATOGENESIS ID ADULT-RATS; SPERMATOGENESIS AB Quantitative assessment of spermatogenesis by flow cytometry reproducibly correlates with histological examination. Flow cytometry of fine needle aspirates from the testis was used to analyze normal spermatogenesis of Sprague-Dawley rats. Aged matched male weanlings were divided into 3 groups: group 1-5 rats underwent bilateral percutaneous aspiration of the testes with a 22 gauge Chiba needle on postpartum days 19, 24, 30 and 40; group 2-5 rats aspirated on days 24, 30 and 40, and group 3-4 rats aspirated on days 30 and 40. This sequential approach allowed for evaluation of normal spermatogenesis and the effects of repeated fine needle aspiration on spermatogenesis. Deoxyribonucleic acid distribution analysis by flow cytometry correlates with haploid (1N), diploid (2N), tetraploid (4N) and S phase cell populations. These cell populations were evaluated and comparisons among each group were made at all biopsy times. No significant differences in mean 2N, 4N or S phase cell populations in single versus repeat biopsied testes were detected. However, there was a significant increase in the 1N population at 30 days post partum in the repeat biopsy group (p = 0.037), which normalized by day 40. This increase in 1N corresponds to the beginning of meiosis, which is maximal between postpartum days 30 and 40, and occurs earlier in the repeat biopsied testis. Repeat fine needle aspiration of the testis can be performed without significantly affecting spermatogenesis in the "weanling" rat. This provides a useful technique in the future investigations of the time related effects of varicocele, chemotherapy and toxicologic drugs on spermatogenesis. C1 WALTER REED ARMY MED CTR,DEPT COMPARAT PATHOL,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,DEPT CELLULAR PATHOL,WASHINGTON,DC 20306. WALTER REED ARMY MED CTR,DEPT EXPTL SURG,WASHINGTON,DC 20307. RP SKOOG, SJ (reprint author), WALTER REED ARMY MED CTR,DEPT UROL,WASHINGTON,DC 20307, USA. NR 17 TC 14 Z9 14 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD AUG PY 1991 VL 146 IS 2 BP 620 EP 623 PN 2 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA FZ776 UT WOS:A1991FZ77600029 PM 1861314 ER PT J AU SZLYK, PC FRANCESCONI, RP ROSE, MS SILS, IV MAHNKE, RB MATTHEW, WT WHANG, R AF SZLYK, PC FRANCESCONI, RP ROSE, MS SILS, IV MAHNKE, RB MATTHEW, WT WHANG, R TI INCIDENCE OF HYPOHYDRATION WHEN CONSUMING CARBOHYDRATE-ELECTROLYTE SOLUTIONS DURING FIELD TRAINING SO MILITARY MEDICINE LA English DT Article AB Carbohydrate-electrolyte solutions (CE1, CE2) were evaluated for their ability to reduce the incidence of hypohydration during field training in hot weather (max T(amb) = 88-degrees-100-degrees-F). Hydration status was monitored twice daily in Army reservists who consumed ad libitum CE1, or CE2, or water, or a flavored water placebo. The water group had the highest percentage incidence of urine specific gravity greater-than-or-equal-to 1.030 (22%), whereas CE2 and flavored water placebo groups had the lowest (6% and 8%, respectively). Average total fluid intake was greatest in CE2 and lowest in CE1. CE2 and flavored water placebo were more effective than CE1 and water in reducing the overall incidence of hypohydration during this field exercise. RP SZLYK, PC (reprint author), USA,ENVIRONM MED RES INST,NATICK,MA 01760, USA. NR 0 TC 4 Z9 4 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 1991 VL 156 IS 8 BP 399 EP 402 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA GB576 UT WOS:A1991GB57600011 PM 1956528 ER PT J AU JENNINGS, BM MCCLURE, ML AF JENNINGS, BM MCCLURE, ML TI MILITARY NURSING AND DIAGNOSIS-RELATED GROUPS - USING THE PAST TO BENEFIT OUR FUTURE SO MILITARY MEDICINE LA English DT Article AB To contain the escalating cost of health care, a prospective payment system is being introduced into the military. The authors propose a proactive approach to this change in health care financing by evaluating the experiences of nurses to a similar change in the civilian sector. These approaches are presented as nine interrelated lessons: responding optimistically; shifting into a business mode; valuing clinical nursing experts; understanding the implications for documentation; moving to decentralized management; changing outpatient care delivery; considering the effects on job satisfaction; evaluating the relationship between costs and nursing resource consumption; and basing nursing practice in science. RP JENNINGS, BM (reprint author), USA,HLTH SERV COMMAND,DIV HLTH CARE STUDIES,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 1991 VL 156 IS 8 BP 408 EP 412 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA GB576 UT WOS:A1991GB57600014 PM 1956531 ER PT J AU YOUNGREN, MA AF YOUNGREN, MA TI DEPENDENCE IN TARGET ELEMENT DETECTIONS INDUCED BY THE ENVIRONMENT SO NAVAL RESEARCH LOGISTICS LA English DT Article ID LIFE AB When modeling the detection of targets in a simulation of combat, the detection process is frequently represented as a series of independent detections of individual elements of the target. This assumption ignores the effect of a common but unknown field environment within which the detections take place. In this article, multivariate survival distributions are developed for target element detections which occur in an unknown dynamic environment. A proportional hazards representation is adopted, which uses a random variable multiplying the detection rate to account for the effect of the environment. Several special cases are examined which are useful for modeling target unit detections. RP YOUNGREN, MA (reprint author), USA,CONCEPTS ANAL AGCY,BETHESDA,MD 20814, USA. NR 18 TC 5 Z9 5 U1 0 U2 0 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0894-069X J9 NAV RES LOG JI Nav. Res. Logist. PD AUG PY 1991 VL 38 IS 4 BP 567 EP 577 DI 10.1002/1520-6750(199108)38:4<567::AID-NAV3220380409>3.0.CO;2-0 PG 11 WC Operations Research & Management Science SC Operations Research & Management Science GA FY787 UT WOS:A1991FY78700008 ER PT J AU LETTERIE, GS HIBBERT, ML AF LETTERIE, GS HIBBERT, ML TI LAPAROSCOPIC EXCISION OF OVARIAN NEOPLASMS SUBSEQUENTLY FOUND TO BE MALIGNANT SO OBSTETRICS AND GYNECOLOGY LA English DT Letter RP LETTERIE, GS (reprint author), TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,REPROD ENDOCRINOL SERV,HONOLULU,HI 96859, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD AUG PY 1991 VL 78 IS 2 BP 320 EP 321 PG 2 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA FX722 UT WOS:A1991FX72200036 ER PT J AU DUARTE, FJ DAVENPORT, WE EHRLICH, JJ TAYLOR, TS AF DUARTE, FJ DAVENPORT, WE EHRLICH, JJ TAYLOR, TS TI RUGGEDIZED NARROW-LINEWIDTH DISPERSIVE DYE-LASER OSCILLATOR SO OPTICS COMMUNICATIONS LA English DT Article AB A ruggedized flashlamp-pumped multiple-prism grating oscillator is shown to yield output energies in the 2-3 mJ range at linewidths close to 300 MHz. The measured beam divergence was less-than-or-equal-to 0.5 mrad. Wavelength stability was determined to be in the 4.63 x 10(-7)-1.45 x 10(-6) range. The dispersive oscillator was constructed of super-invar for thermal and mechanical stability. The mechanical integrity of this cavity was tested in the field using vehicular displacement on a rugged terrain. Laser linewidth and beam quality characteristics of the dispersive oscillator were not affected adversely by the field test. C1 USA,MISSILE COMMAND,CTR RES DEV & ENGN,REDSTONE ARSENAL,AL 35898. RP DUARTE, FJ (reprint author), EASTMAN KODAK CO,PHOTOGRAPH PROD GRP,PHOTOGRAPH RES LABS,ROCHESTER,NY 14650, USA. NR 6 TC 11 Z9 11 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0030-4018 J9 OPT COMMUN JI Opt. Commun. PD AUG 1 PY 1991 VL 84 IS 5-6 BP 310 EP 316 DI 10.1016/0030-4018(91)90093-S PG 7 WC Optics SC Optics GA GC746 UT WOS:A1991GC74600018 ER PT J AU STRONG, WE BLANCHARD, J RAMAMURTHY, S HOFFMAN, J AF STRONG, WE BLANCHARD, J RAMAMURTHY, S HOFFMAN, J TI DOES THE SYMPATHETIC BLOCK OUTLAST SENSORY BLOCK - A THERMOGRAPHIC EVALUATION SO PAIN LA English DT Article DE ANESTHETIC TECHNIQUES; REGIONAL, SYMPATHETIC BLOCK; SYMPATHETIC DYSTROPHY ID SPINAL ANALGESIA; ANESTHESIA; TEMPERATURE; MECHANISMS; NERVE AB A study to evaluate the duration of sympathetic and sensory block in the L2 and L5 dermatome distributions using thermography and pinprick was conducted. Twenty patients received epidural block using 2% lidocaine with epinephrine. Onset and duration of the sensory and sympathetic blocks were determined and compared statistically. There was no difference between the duration of sensory and sympathetic block over the L2 dermatome, but sympathetic block was significantly longer than sensory block in the L5 dermatome. This study demonstrates that the duration of sympathetic block can be either longer or shorter than sensory block in L2 and L5 dermatomes. This has important implications for interpretation of results of differential epidural studies in that one cannot predict the duration of sympathetic block based on duration of sensory block. C1 UNIV TEXAS,HLTH SCI CTR,DEPT ANESTHESIOL,SAN ANTONIO,TX 78284. RP STRONG, WE (reprint author), BROOKE ARMY MED CTR,ANESTHESIA & OPERAT SERV,FT SAM HOUSTON,TX 78234, USA. NR 26 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3959 J9 PAIN JI Pain PD AUG PY 1991 VL 46 IS 2 BP 173 EP 176 DI 10.1016/0304-3959(91)90072-6 PG 4 WC Anesthesiology; Clinical Neurology; Neurosciences SC Anesthesiology; Neurosciences & Neurology GA GD015 UT WOS:A1991GD01500009 PM 1749639 ER PT J AU JONES, RG BASS, JW WEISSE, ME VINCENT, JM AF JONES, RG BASS, JW WEISSE, ME VINCENT, JM TI ANTIGENURIA AFTER IMMUNIZATION WITH HAEMOPHILUS-INFLUENZAE OLIGOSACCHARIDE CRM197 CONJUGATE (HBOC) VACCINE SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE HAEMOPHILUS-INFLUENZAE B; HAEMOPHILUS-B CONJUGATE VACCINE; ANTIGENURIA; HBOC; HIBTITTER AB We tested the urine of 30 infants 6 weeks to 7 months of age after they received standard 10-mu-g (0.5-ml) doses of HbOC (HibTITER(R)) Haemophilus influenzae b (Hib) conjugate vaccine for the presence of Hib antigenuria using a commercially available latex particle agglutination assay (Directigen(R)). Urines were collected within 1 hour, from 1 to 3 hours, at 24 hours and at 3, 6 and 9 days after vaccine administration and reactions were quantitated from 0 to 3+. In contrast to previous studies in older children which showed little or no antigenuria following HbOC vaccination, our study shows that in infants intense Hib antigenuria is evident within 2 to 3 hours and persists 3 days after vaccine administration and that less intense antigenuria may be detected in some infants for several days. With efficacious vaccines now being used in 2- to 6-month-old infants, invasive Hib disease may soon be limited to infants of this age just before their seroconversion. It should be recognized that antigenuria occurs for several days after vaccination with Hib conjugate vaccines and that it could be erroneously interpreted as evidence of invasive Hib infection. C1 TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859. NR 9 TC 6 Z9 6 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD AUG PY 1991 VL 10 IS 8 BP 557 EP 559 DI 10.1097/00006454-199108000-00001 PG 3 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA GA463 UT WOS:A1991GA46300001 PM 1891285 ER PT J AU FRANCIS, GL JELINEK, JJ MCHALE, K ADAMSON, M LEVIN, SW AF FRANCIS, GL JELINEK, JJ MCHALE, K ADAMSON, M LEVIN, SW TI THE WEISMANN-NETTER SYNDROME - A CAUSE OF BOWED LEGS IN CHILDHOOD SO PEDIATRICS LA English DT Note C1 WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT ORTHOPED,WASHINGTON,DC 20307. NICHHD,HUMAN GENET BRANCH,BETHESDA,MD 20892. RP FRANCIS, GL (reprint author), WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC 20307, USA. NR 10 TC 5 Z9 5 U1 0 U2 0 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD, ELK GROVE VILLAGE, IL 60007-1098 SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD AUG PY 1991 VL 88 IS 2 BP 334 EP 337 PG 4 WC Pediatrics SC Pediatrics GA GA164 UT WOS:A1991GA16400023 PM 1861935 ER PT J AU RUSTAD, JR YUEN, DA SPERA, FJ AF RUSTAD, JR YUEN, DA SPERA, FJ TI MOLECULAR-DYNAMICS OF AMORPHOUS SILICA AT VERY HIGH-PRESSURES (135 GPA) - THERMODYNAMICS AND EXTRACTION OF STRUCTURES THROUGH ANALYSIS OF VORONOI POLYHEDRA SO PHYSICAL REVIEW B LA English DT Article ID COMPUTER-SIMULATION; THERMAL-EXPANSION; LIQUID; SIO2; COMPRESSION; QUARTZ; MANTLE AB Using equilibrium molecular-dynamics techniques, we have investigated the equation of state and structural characteristics of amorphous silica up to 135 GPa in the temperature range 300-2500 K, fully incorporating anharmonic effects within the context of the classical approximation. The thermal expansivity and constant-volume heat capacity both decrease with increasing pressure. There is a weak maximum in the thermal expansivity in the 20-30-GPa range. The structure of amorphous silica is described with use of Voronoi polyhedra and the connectivity of edge-sharing coordination polyhedra. Basic coordination states for sevenfold- and eightfold-coordinated silicon atoms have been identified. The pressure-induced invasion of cubic silicon-centered Voronoi polyhedra by two oxygen atoms tends to occur on edge-sharing corners whereas invasion involving more than two oxygen atoms tends to be randomly distributed. The distribution of volumes of silicon-centered Voronoi polyhedra shows an anomalous variance near 70 GPa that is associated with a rapid rise in the connectivity of edge-sharing coordination polyhedra. This phenomenon may be related to the high-pressure enhancement of shear strength in silica glass previously observed experimentally. C1 UNIV MINNESOTA,DEPT GEOL & GEOPHYS,MINNEAPOLIS,MN 55415. UNIV CALIF SANTA BARBARA,DEPT GEOL SCI,SANTA BARBARA,CA 93106. UNIV CALIF SANTA BARBARA,INST CRUSTAL STUDIES,SANTA BARBARA,CA 93106. RP RUSTAD, JR (reprint author), UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,MINNESOTA SUPERCOMP INST,MINNEAPOLIS,MN 55415, USA. NR 30 TC 46 Z9 46 U1 0 U2 9 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD AUG 1 PY 1991 VL 44 IS 5 BP 2108 EP 2121 DI 10.1103/PhysRevB.44.2108 PG 14 WC Physics, Condensed Matter SC Physics GA GA076 UT WOS:A1991GA07600013 ER PT J AU DOWLING, JP AF DOWLING, JP TI CONJUGAL WRITES SO PHYSICS WORLD LA English DT Letter RP DOWLING, JP (reprint author), USA,MISSILE RES & DEV COMMAND,REDSTONE ARSENAL,AL 35809, USA. RI DOWLING, JONATHAN/L-2749-2013 NR 0 TC 0 Z9 0 U1 0 U2 0 PU IOP PUBLISHING LTD PI BRISTOL PA TECHNO HOUSE, REDCLIFFE WAY, BRISTOL, ENGLAND BS1 6NX SN 0953-8585 J9 PHYS WORLD JI Phys. World PD AUG PY 1991 VL 4 IS 8 BP 21 EP 21 PG 1 WC Physics, Multidisciplinary SC Physics GA FZ751 UT WOS:A1991FZ75100023 ER PT J AU SHAFFERMAN, A JAHRLING, PB BENVENISTE, RE LEWIS, MG PHIPPS, TJ EDENMCCUTCHAN, F SADOFF, J EDDY, GA BURKE, DS AF SHAFFERMAN, A JAHRLING, PB BENVENISTE, RE LEWIS, MG PHIPPS, TJ EDENMCCUTCHAN, F SADOFF, J EDDY, GA BURKE, DS TI PROTECTION OF MACAQUES WITH A SIMIAN IMMUNODEFICIENCY VIRUS ENVELOPE PEPTIDE VACCINE BASED ON CONSERVED HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 SEQUENCES SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE ENVELOPE EPITOPES; AIDS; IMMUNITY ID HTLV-III; ANTIBODY RECOGNITION; GLYCOPROTEIN GP120; HIV INFECTION; CHIMPANZEES; RETROVIRUS; RECOMBINANT; LENTIVIRUS; CHALLENGE; MANGABEYS AB This report describes the vaccination of rhesus macaques with peptides selected from regions of the simian immunodeficiency virus (SIV) envelope that are hydrophilic, immunoreactive, and highly homologous with corresponding conserved envelope sequences of the human immunodeficiency virus (HIV). The peptides, produced as beta-galactosidase fusion proteins, induced virus-neutralizing and peptide-specific antibodies. After challenge with virulent virus, controls became virus positive and developed gradually rising antibody titers to SIV over 63 weeks. Immunized macaques developed a postchallenge anamnestic response to SIVenv antigens within 3-6 weeks followed by a gradual, fluctuating decline in SIV antibody titers and partial or total suppression of detectable SIV. Virus suppression correlated with prechallenge neutralizing antibody titers. Although the average CD4+ cell count in the blood of immunized macaques remained constant, the control macaques exhibited a progressive decrease developing about week 55 after challenge. The conserved nature of the HIV and SIV peptides and the similar humoral immunoreactivity in the respective hosts suggest that homologous HIV peptides may be important components of a successful immunization strategy. C1 USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FREDERICK,MD 21701. FREDERICK RES CTR,SO RES INST,FREDERICK,MD 21701. NCI,VIRAL CARCINOGENESIS LAB,FREDERICK,MD 21702. HENRY M JACKSON FDN,RES LAB,ROCKVILLE,MD 20850. WALTER REED ARMY MED CTR,DEPT RETROVIROL,WASHINGTON,DC 20307. RP SHAFFERMAN, A (reprint author), ISRAEL INST BIOL RES,DEPT BIOCHEM,IL-70450 NESS ZIONA,ISRAEL. OI /0000-0002-5704-8094 NR 25 TC 104 Z9 104 U1 0 U2 3 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD AUG PY 1991 VL 88 IS 16 BP 7126 EP 7130 DI 10.1073/pnas.88.16.7126 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA GB701 UT WOS:A1991GB70100046 PM 1871125 ER PT J AU HUSS, K SALERNO, M HUSS, RW AF HUSS, K SALERNO, M HUSS, RW TI COMPUTER-ASSISTED REINFORCEMENT OF INSTRUCTION - EFFECTS ON ADHERENCE IN ADULT ATOPIC ASTHMATICS SO RESEARCH IN NURSING & HEALTH LA English DT Article ID HOUSE DUST MITES; SEASONAL-VARIATION; PATIENT EDUCATION; CHILDHOOD ASTHMA; CHILDREN; ALLERGENS; TRIAL; ANTIBODIES C1 CATHOLIC UNIV AMER,SCH NURSING,PRIMARY CARE ADULTS NURSE PRACTITIONER PROGRAM,BETHESDA,MD. HUSS & HUSS ALLERGY IMMUNOL PRACTICE,BETHESDA,MD. RP HUSS, K (reprint author), WALTER REED ARMY MED CTR,ALLERGY IMMUNOL SERV,WASHINGTON,DC 20307, USA. NR 35 TC 34 Z9 34 U1 0 U2 2 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0160-6891 J9 RES NURS HEALTH JI Res. Nurs. Health PD AUG PY 1991 VL 14 IS 4 BP 259 EP 267 DI 10.1002/nur.4770140404 PG 9 WC Nursing SC Nursing GA FX436 UT WOS:A1991FX43600003 PM 1891611 ER PT J AU CARROUGHER, JG SHAFFER, RT CANALES, LI GOODMAN, ZD AF CARROUGHER, JG SHAFFER, RT CANALES, LI GOODMAN, ZD TI A 33-YEAR-OLD WOMAN WITH AN AUTOIMMUNE SYNDROME SO SEMINARS IN LIVER DISEASE LA English DT Review ID PRIMARY BILIARY-CIRRHOSIS; CHRONIC ACTIVE HEPATITIS; ANTIMITOCHONDRIAL ANTIBODIES; LIVER-INJURY; SARCOIDOSIS; CHOLESTASIS; CHOLANGITIS; GRANULOMAS; FEATURES C1 ARMED FORCES INST PATHOL,DIV HEPAT PATHOL,WASHINGTON,DC 20306. BROOKE ARMY MED CTR,DIV GASTROENTEROL,SAN ANTONIO,TX. NR 31 TC 27 Z9 27 U1 0 U2 0 PU THIEME MEDICAL PUBL INC PI NEW YORK PA 381 PARK AVE SOUTH, NEW YORK, NY 10016 SN 0272-8087 J9 SEMIN LIVER DIS JI Semin. Liver Dis. PD AUG PY 1991 VL 11 IS 3 BP 256 EP 262 DI 10.1055/s-2008-1040444 PG 7 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA GM358 UT WOS:A1991GM35800011 PM 1925651 ER PT J AU RONG, FC BUCHWALD, WR POINDEXTER, EH WARREN, WL KEEBLE, DJ AF RONG, FC BUCHWALD, WR POINDEXTER, EH WARREN, WL KEEBLE, DJ TI SPIN-DEPENDENT SHOCKLEY-READ RECOMBINATION OF ELECTRONS AND HOLES IN INDIRECT-BAND-GAP SEMICONDUCTOR P-N-JUNCTION DIODES SO SOLID-STATE ELECTRONICS LA English DT Article ID MAGNETIC-RESONANCE; DEEP-LEVEL; SILICON; INTERFACE; DEFECT AB This paper presents a new model for spin-dependent recombination and generation processes based on the electrical detection of magnetic resonance in semiconductor p-n junction diodes. Based on a modified Shockley-Read recombination statistics, this model differs from those models previously proposed in that the spin-dependent enhancement of free-carrier capture processes can occur directly at a paramagnetic deep defect without the need for other defects nearby. This model incorporates singlet-triplet mechanisms of existing models, but is shown to be consistent with new experimental results which indicate the absence of any adjacent trapping centers. C1 SANDIA NATL LABS,ALBUQUERQUE,NM 87185. USA,COMMAND LAB,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. MICHIGAN TECHNOL UNIV,DEPT PHYS,HOUGHTON,MI 49931. RI Keeble, David /C-6633-2012 OI Keeble, David /0000-0002-5378-799X NR 19 TC 48 Z9 48 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0038-1101 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD AUG PY 1991 VL 34 IS 8 BP 835 EP 841 DI 10.1016/0038-1101(91)90229-R PG 7 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA FY094 UT WOS:A1991FY09400006 ER PT J AU ROCHON, RB MOZINGO, DW WEIGELT, JA AF ROCHON, RB MOZINGO, DW WEIGELT, JA TI NEW MODES OF MECHANICAL VENTILATION SO SURGICAL CLINICS OF NORTH AMERICA LA English DT Article ID HIGH-FREQUENCY VENTILATION; PRESSURE RELEASE VENTILATION; POSITIVE AIRWAY PRESSURE; RESPIRATORY-DISTRESS SYNDROME; JET VENTILATION; SUPPORT VENTILATION; CONVENTIONAL VENTILATION; PULMONARY-FUNCTION; INSPIRATORY WORK; FAILURE C1 UNIV TEXAS,SW MED CTR,SURG CRIT CARE & TRAUMA SURG SECT,5323 HARRY HINES BLVD,DALLAS,TX 75235. UNIV TEXAS,SW MED CTR,DEPT SURG,DALLAS,TX 75235. BROOKE ARMY MED CTR,CRIT CARE SERV,SURG INTENS CAR UNIT,FT SAM HOUSTON,TX 78234. NR 55 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0039-6109 J9 SURG CLIN N AM JI Surg. Clin.-North Am. PD AUG PY 1991 VL 71 IS 4 BP 843 EP 858 PG 16 WC Surgery SC Surgery GA JC372 UT WOS:A1991JC37200011 PM 1862472 ER PT J AU TAYLOR, TJ PARKER, GW FAJER, AB MEREISH, KA AF TAYLOR, TJ PARKER, GW FAJER, AB MEREISH, KA TI NONSPECIFIC-BINDING OF PALYTOXIN TO PLASTIC SURFACES SO TOXICOLOGY LETTERS LA English DT Article DE PALYTOXIN; SODIUM NITROPRUSSIDE; BLOOD PRESSURE; BINDING ID CARBOXYLIC-ACID; ERYTHROCYTES AB The changes in blood pressure induced by palytoxin (PTX) administered intravenously through polyethylene (PE) tubing were varied, suggesting either non-specific binding of the toxin to PE or deactivation. By spectrophotometry and HPLC, we found that PTX bound non-specifically to PE tubing and that this binding was attenuated by adding 0.1% rat serum albumin. Furthermore, the chemical stability and activity of PTX were not affected by exposure to room light and/or room temperature. Biological deactivation was excluded as a cause of the observed variability because the hypertensive and lethal effects of infused PTX, delayed with simultaneous administration of sodium nitroprusside (NNP), were in full evidence when the NNP was discontinued 35 min later. C1 UNIV MARYLAND,DEPT PHYSIOL,BALTIMORE,MD 21201. UNIV MARYLAND,DIV MED,BALTIMORE,MD 21201. RP TAYLOR, TJ (reprint author), USA,MED RES INST INFECT DIS,DIV PATHOPHYSIOL,FREDERICK,MD 21702, USA. NR 12 TC 5 Z9 5 U1 1 U2 1 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0378-4274 J9 TOXICOL LETT JI Toxicol. Lett. PD AUG PY 1991 VL 57 IS 3 BP 291 EP 296 DI 10.1016/0378-4274(91)90203-I PG 6 WC Toxicology SC Toxicology GA GC028 UT WOS:A1991GC02800006 PM 1679259 ER PT J AU PHILLIPS, TH THOMPSON, IM AF PHILLIPS, TH THOMPSON, IM TI DIGITAL RECTAL EXAMINATION AND CARCINOMA OF THE PROSTATE SO UROLOGIC CLINICS OF NORTH AMERICA LA English DT Article; Proceedings Paper CT SYMP ON UROLOGIC ONCOLOGY, IN HONOR OF DR WILLET F WHITMORE CY DEC 05-08, 1990 CL MEM SLOAN KETTERING CANC CTR, MANHATTAN, NY HO MEM SLOAN KETTERING CANC CTR ID CANCER; ULTRASOUND C1 JOINT MIL MED COMMAND,DEPT UROL,SAN ANTONIO,TX. BROOKE ARMY MED CTR,DEPT SURG,DEPT CLIN INVESTIGAT,UROL SERV,FT SAM HOUSTON,TX 78234. NR 13 TC 21 Z9 22 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0094-0143 J9 UROL CLIN N AM JI Urol. Clin. N. Am. PD AUG PY 1991 VL 18 IS 3 BP 459 EP 465 PG 7 WC Urology & Nephrology SC Urology & Nephrology GA GM558 UT WOS:A1991GM55800008 PM 1877107 ER PT J AU MOUL, JW HARDY, MR MCLEOD, DG AF MOUL, JW HARDY, MR MCLEOD, DG TI ADRENAL-CORTICAL CARCINOMA WITH VENA-CAVA TUMOR THROMBUS REQUIRING CARDIOPULMONARY BYPASS FOR RESECTION SO UROLOGY LA English DT Article ID RENAL-CELL-CARCINOMA; RIGHT ATRIUM; MANAGEMENT; EXTENSION; REMOVAL AB We believe this is the fifteenth case report of adrenal cortical carcinoma with tumor thrombus to the vena cava, and the fourth reported case of a left-side tumor propagating thrombus to the vena cava. The patient underwent successful resection which required cardiopulmonary bypass. The caval tumor thrombus was very friable and gelatinous, unlike many renal cell thrombi, and required special surgical considerations. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. RP MOUL, JW (reprint author), WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307, USA. NR 16 TC 14 Z9 14 U1 0 U2 0 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0090-4295 J9 UROLOGY JI UROLOGY PD AUG PY 1991 VL 38 IS 2 BP 179 EP 183 DI 10.1016/S0090-4295(05)80083-4 PG 5 WC Urology & Nephrology SC Urology & Nephrology GA GB101 UT WOS:A1991GB10100019 PM 1877139 ER PT J AU PALAZZO, AJ REYNOLDS, CM AF PALAZZO, AJ REYNOLDS, CM TI LONG-TERM CHANGES IN SOIL AND PLANT METAL CONCENTRATIONS IN AN ACIDIC DREDGE DISPOSAL SITE RECEIVING SEWAGE-SLUDGE SO WATER AIR AND SOIL POLLUTION LA English DT Article; Proceedings Paper CT INTERNATIONAL CONF ON METALS IN SOILS, WATERS, PLANTS AND ANIMALS CY APR 30-MAY 03, 1990 CL ORLANDO, FL SP US DOE, SAVANNAH RIV OPERAT OFF ID HEAVY-METALS; TALL FESCUE; ACCUMULATION; TERMINATION; ORGANICS; ZINC; CORN AB A long-term experiment was conducted to determine the distribution of sludge-borne metals applied to a revegetated acidic dredge spoil disposal site. The initial soil was infertile and highly acidic (pH 2.4). Sewage sludge and lime were applied in 1974 at the rates of 100 and 23 mt ha-1, respectively, and tilled into the soil to a depth of 20 cm. In 1974 an adjacent site was also revegetated with topsoil and lime but without sludge. Soil and plants were sampled 2, 4 and 16 yr following seeding. After 16 yr the total and DTPA-extractable Cu, Zn, Cr, Pb, Ni and Cd decreased in soils to nearly the levels of the control soils. Concentrations of metals in plants also decreased. Decreases in tissue concentrations ranged from 40 to 70% for Cu, Cr, Pb, Ni and Cd and up to 90% for Zn. The results showed that a single 100 mt ha-1 application of sewage sludge containing high concentrations of metals was a cost-effective method for improving plant growing conditions on highly acidic soils. RP PALAZZO, AJ (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 28 TC 10 Z9 10 U1 0 U2 3 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0049-6979 J9 WATER AIR SOIL POLL JI Water Air Soil Pollut. PD AUG PY 1991 VL 57-8 BP 839 EP 848 DI 10.1007/BF00282947 PG 10 WC Environmental Sciences; Meteorology & Atmospheric Sciences; Water Resources SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences; Water Resources GA GP121 UT WOS:A1991GP12100086 ER PT J AU WILLIAMS, DC LYON, JG AF WILLIAMS, DC LYON, JG TI USE OF A GEOGRAPHIC INFORMATION-SYSTEM DATA-BASE TO MEASURE AND EVALUATE WETLAND CHANGES IN THE ST-MARYS RIVER, MICHIGAN SO HYDROBIOLOGIA LA English DT Article DE WETLAND; ST-MARYS RIVER; WATER LEVEL; SUCCESSION; GEOGRAPHIC INFORMATION SYSTEM; PHOTO INTERPRETATION ID LAKE AB A digital data base was constructed by photo interpretation, mapping, and digitizing seven dates of aerial photography on the St. Marys River, Michigan, USA. The data base was used in conjunction with geographic information system software to examine historical changes in wetland area. Total wetland area between 1939 and 1985 ranged from 7 200 to 7 317 ha over a 46-year period of high and low water. There was greatest variation in areas of emergent wetland and scrub-shrub wetland, which appeared to be responding primarily to changes in water level. C1 OHIO STATE UNIV,DEPT CIVIL ENGN,COLUMBUS,OH 43210. RP WILLIAMS, DC (reprint author), CORPS ENGINEERS,DETROIT DIST,POB 1027,DETROIT,MI 48231, USA. NR 17 TC 17 Z9 17 U1 0 U2 0 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0018-8158 J9 HYDROBIOLOGIA JI Hydrobiologia PD JUL 26 PY 1991 VL 219 BP 83 EP 95 DI 10.1007/BF00024748 PG 13 WC Marine & Freshwater Biology SC Marine & Freshwater Biology GA GK031 UT WOS:A1991GK03100006 ER PT J AU BEHRENS, R BULUSU, S AF BEHRENS, R BULUSU, S TI THERMAL-DECOMPOSITION OF ENERGETIC MATERIALS .2. DEUTERIUM-ISOTOPE EFFECTS AND ISOTOPIC SCRAMBLING IN CONDENSED-PHASE DECOMPOSITION OF OCTAHYDRO-1,3,5,7-TETRANITRO-1,3,5,7-TETRAZOCINE SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Article ID BEAM MASS-SPECTROMETRY; PYROLYSIS PRODUCTS; HMX; 1,3,5,7-TETRANITRO-1,3,5,7-TETRAAZACYCLOOCTANE; 1,3,5-TRINITRO-1,3,5-TRIAZACYCLOHEXANE; RATES; RDX AB The products formed in the thermal decomposition of octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) have been traced by using mixtures of different isotopically labeled analogues of HMX. The isotopic analogues of HMX used in the experiments include H-2, C-13, (NO2)-N-15, N-15ring, and O-18. The fraction of isotopic scrambling and the extent of the deuterium kinetic isotope effect (DKIE) are reported for the different thermal decomposition products. Isotopic scrambling is not observed for the N-N bond in N2O and the C-H bonds in CH2O. Only one of the C-N bonds in N-methylformamide (NMFA) undergoes isotopic scrambling. The lack of complete isotopic scrambling of the N-NO bond in 1-nitroso-3,5,7-trinitro-1,3,5,7-tetrazocine (ONTNTA) is shown to imply that some HMX decomposition occurs in the lattice. The behavior of the DKIE in different mixtures of isotopic analogues of HMX suggests that water probably acts as a catalyst in the decomposition. The results demonstrate that decomposition of HMX in the condensed phase has several reaction branches. C1 USA,ARMAMENT RES & DEV COMMAND,DIV ENERGET MAT,DOVER,NJ 07801. RP BEHRENS, R (reprint author), SANDIA NATL LABS,COMBUST RES FACIL,LIVERMORE,CA 94551, USA. NR 22 TC 79 Z9 79 U1 0 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD JUL 25 PY 1991 VL 95 IS 15 BP 5838 EP 5845 DI 10.1021/j100168a025 PG 8 WC Chemistry, Physical SC Chemistry GA FY388 UT WOS:A1991FY38800025 ER PT J AU ZIEGLER, EJ FISHER, CJ SPRUNG, CL SMITH, CR STRAUBE, RC SADOFF, JC DELLINGER, RP AF ZIEGLER, EJ FISHER, CJ SPRUNG, CL SMITH, CR STRAUBE, RC SADOFF, JC DELLINGER, RP TI THE HA-1A MONOCLONAL-ANTIBODY FOR GRAM-NEGATIVE SEPSIS - REPLY SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter C1 CASE WESTERN RESERVE UNIV,CLEVELAND,OH 44106. HEBREW UNIV JERUSALEM,HADASSAH MED CTR,IL-91120 JERUSALEM,ISRAEL. CENTOCOR INC,MALVERN,PA 19355. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. BAYLOR UNIV,HOUSTON,TX 77030. RP ZIEGLER, EJ (reprint author), UNIV CALIF SAN DIEGO,MED CTR,SAN DIEGO,CA 92103, USA. NR 3 TC 9 Z9 9 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD JUL 25 PY 1991 VL 325 IS 4 BP 282 EP 283 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA FX627 UT WOS:A1991FX62700019 ER PT J AU PORTER, KR POLO, SL LONG, GW MERRITT, SC OPRANDY, JJ AF PORTER, KR POLO, SL LONG, GW MERRITT, SC OPRANDY, JJ TI A RAPID MEMBRANE-BASED VIRAL-RNA ISOLATION METHOD FOR THE POLYMERASE CHAIN-REACTION SO NUCLEIC ACIDS RESEARCH LA English DT Note ID DOT IMMUNOASSAY C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP PORTER, KR (reprint author), USN,INST MED RES,BLDG 17,STOP 7,BETHESDA,MD 20889, USA. NR 3 TC 1 Z9 1 U1 0 U2 0 PU OXFORD UNIV PRESS UNITED KINGDOM PI OXFORD PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP SN 0305-1048 J9 NUCLEIC ACIDS RES JI Nucleic Acids Res. PD JUL 25 PY 1991 VL 19 IS 14 BP 4011 EP 4011 DI 10.1093/nar/19.14.4011 PG 1 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA FY987 UT WOS:A1991FY98700046 PM 1862001 ER PT J AU VERMA, JN WASSEF, NM WIRTZ, RA ATKINSON, CT AIKAWA, M LOOMIS, LD ALVING, CR AF VERMA, JN WASSEF, NM WIRTZ, RA ATKINSON, CT AIKAWA, M LOOMIS, LD ALVING, CR TI PHAGOCYTOSIS OF LIPOSOMES BY MACROPHAGES - INTRACELLULAR FATE OF LIPOSOMAL MALARIA ANTIGEN SO BIOCHIMICA ET BIOPHYSICA ACTA LA English DT Article DE CIRCUMSPOROZOITE PROTEIN; IMMUNOGOLD ELECTRON MICROSCOPY; LIPID-A; LIPOSOME; MACROPHAGE; PHAGOCYTOSIS; ELECTRON MICROSCOPY; LIPOSOMAL MALARIA ANTIGEN ID KUPFFER CELLS-INVITRO; IMMUNOGLOBULIN-COATED LIPOSOMES; RAT-LIVER MACROPHAGES; PHOSPHATIDYLINOSITOL LIPOSOMES; ENDOCYTOSIS; LYSOSOMES; ADJUVANTS; ENZYMES AB Liposomes containing a synthetic recombinant protein were phagocytosed by macrophages, and the internalized protein was recycled to the cell surfaces where it was detected by enzyme-linked immunosorbent assay. The transit time of the liposome-encapsulated protein from initial phagocytosis of liposomes to appearance of protein on the surfaces of macrophages was determined by pulse-chase experiments. The macrophages were pulsed with liposomes containing protein and chased with empty liposomes, and vice versa. The amount and rate of protein antigen expression at the cell surfaces depended on the quantity of encapsulated protein ingested by the macrophages. Although liposomes were rapidly taken up by macrophages, the liposome-encapsulated protein was antigenically expressed for a prolonged period (at least 24 h) on the cell surface. Liposomes were visualized inside vacuoles in the macrophages by immunogold electron microscopy. The liposomes accumulated along the peripheries of the vacuoles and many of them apparently remained intact for a long time (> 6 h). However, nonliposomal free protein was also detected in the cytoplasm surrounding these vacuoles, and it was concluded that the free protein in the cytoplasm was probably en route to the macrophage surface. Exposure of the cells to ammonium chloride did not inhibit the appearance of liposomal antigenic epitopes on the cell surface, and this suggests that expression of the liposomal antigenic epitopes at the surface was not a pH-sensitive phenomenon. There was no significant effect of a liposomal adjuvant, lipid A, on the rate or extent of surface expression of the liposomal protein. C1 WALTER REED ARMY MED CTR,DEPT MEMBRANE BIOCHEM,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT ENTOMOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT IMMUNOL,WASHINGTON,DC 20307. CASE WESTERN RESERVE UNIV,SCH MED,INST PATHOL,CLEVELAND,OH 44106. FU NIAID NIH HHS [AI-10645] NR 38 TC 42 Z9 44 U1 1 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0006-3002 J9 BIOCHIM BIOPHYS ACTA PD JUL 22 PY 1991 VL 1066 IS 2 BP 229 EP 238 DI 10.1016/0005-2736(91)90191-A PG 10 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA FZ618 UT WOS:A1991FZ61800015 PM 1854787 ER PT J AU WANG, J PEIFFER, DG SHUELY, WJ CHU, B AF WANG, J PEIFFER, DG SHUELY, WJ CHU, B TI RHEOLOGICAL PROPERTIES AND ASSOCIATION BEHAVIOR OF MIXTURES OF POLY[ISOBUTYL METHACRYLATE (TERT-BUTYLAMINO)ETHYL METHACRYLATE] AND AN IONOMER IN SOLUTION SO MACROMOLECULES LA English DT Article ID METAL SULFONATE IONOMERS; LIGHT-SCATTERING; NEUTRON-SCATTERING; RANDOM COPOLYMER; POLYSTYRENE; RHEOMETER; SOLVENTS; SYSTEMS AB The rheological properties and association behavior for polymer-polymer complexes consisting of a random copolymer, poly[isobutyl methacrylate-(tert-butylamino)ethyl methacrylate] [poly(iBMA-tBAEMA)], and an ionomer, a zinc salt of sulfonated polystyrene, in polar solvents have been measured by a magnetic needle rheometer and laser light scattering. The dramatic changes in the reduced viscosity as a function of polymer composition, concentration, cosolvent quality, temperature, and shear rate were examined by using the copolymer as the reference. The aggregate structures of the copolymer and the polymer-polymer complexes at semidilute concentrations and different polymer compositions were postulated on the basis of light scattering observations. Since the polymer-polymer complexes are very effective rheological control additives, they could be useful in a wide variety of applications, such as thickening and antimisting applications. C1 SUNY STONY BROOK,DEPT CHEM,STONY BROOK,NY 11794. USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. EXXON RES & ENGN CO,CORP RES SCI LAB,ANNANDALE,NJ 08801. SUNY STONY BROOK,DEPT MAT SCI & ENGN,STONY BROOK,NY 11794. NR 27 TC 3 Z9 3 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD JUL 22 PY 1991 VL 24 IS 15 BP 4349 EP 4355 DI 10.1021/ma00015a016 PG 7 WC Polymer Science SC Polymer Science GA FY047 UT WOS:A1991FY04700016 ER PT J AU SHEN, H DUTTA, M LUX, R BUCHWALD, W FOTIADIS, L SACKS, RN AF SHEN, H DUTTA, M LUX, R BUCHWALD, W FOTIADIS, L SACKS, RN TI DYNAMICS OF PHOTOREFLECTANCE FROM UNDOPED GAAS SO APPLIED PHYSICS LETTERS LA English DT Article ID PUMP CHOPPING FREQUENCY; SURFACE FERMI LEVEL; HG1-XCDXTE; DEPENDENCE AB We have studied the time constants involved in photoreflectance from several GaAs surface-intrinsic-n+ structures. The rise and fall times were determined from digital oscilloscope traces. We find that they depend on the intensity and wavelength of the pump and probe beams. The observed photoreflectance feature does not always follow a single exponential decay. The dependence of rise and fall times on intensity and wavelength of pump and probe beams can be accounted for by a theory based on majority-carrier flow. The characteristic time obtained can be used to determine the potential barrier height. C1 USA,ELECTR TECHNOL & DEVICES LAB,SLCET-ED,FT MONMOUTH,NJ 07703. UNITED TECHNOL RES CTR,E HARTFORD,CT 06108. NR 19 TC 42 Z9 43 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUL 15 PY 1991 VL 59 IS 3 BP 321 EP 323 DI 10.1063/1.105583 PG 3 WC Physics, Applied SC Physics GA FW744 UT WOS:A1991FW74400024 ER PT J AU MORRISON, CA GRUBER, JB HILLS, ME AF MORRISON, CA GRUBER, JB HILLS, ME TI ENERGY-LEVELS OF CR3+ IONS IN C3I SITES OF Y3AL5O12 SO CHEMICAL PHYSICS LA English DT Article ID SPECTRA; DEPENDENCE AB From an analysis of the ultraviolet absorption spectrum of Cr3+ ions in Y3Al5O12 we have obtained a sufficient number of energy levels to perform a crystal-field splitting calculation for Cr3+ ions in sites of C3i symmetry in the lattice. The Hamiltonian used included Coulombic, crystal-field (C3i symmetry), spin-orbit interaction, and effective interconfiguration interaction terms and was diagonalized within the complete basis for 3d3 atomic configuration. The calculated energy levels were compared with experimental levels up to 40000 cm-1. From the data, we have assigned 29 Stark levels to Cr3+ ions in C3i sites which agree with calculated levels to within an rms deviation of 18 cm-1. The values of the parameters that give the best agreement are F(2) = 52724, F(4) = 38380, zeta = 252, alpha = 132, gamma = -124, B20 = 1091, B40 = -21574, and B43 = 27224 cm-1 (Dq = 1605, nu = 891, and nu' = -104.8 cm-1). The crystal-field splitting of Cr3+ levels in S4 lattice sites is also predicted with the use of the free-ion parameters obtained in this paper and a point-charge lattice-sum model. C1 SAN JOSE STATE UNIV, DEPT PHYS, SAN JOSE, CA 95192 USA. USN, CTR WEAP, DEPT RES, DIV CHEM, CHINA LAKE, CA 93555 USA. RP USA, ELECTR RES & DEV COMMAND, HARRY DIAMOND LABS, ADELPHI, MD 20783 USA. NR 26 TC 13 Z9 13 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0301-0104 EI 1873-4421 J9 CHEM PHYS JI Chem. Phys. PD JUL 15 PY 1991 VL 154 IS 3 BP 437 EP 447 DI 10.1016/0301-0104(91)85026-D PG 11 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA FW851 UT WOS:A1991FW85100008 ER PT J AU STEVENS, SB MORRISON, CA SELTZER, MD HILLS, ME GRUBER, JB AF STEVENS, SB MORRISON, CA SELTZER, MD HILLS, ME GRUBER, JB TI EMISSION MEASUREMENTS AND CRYSTAL-FIELD CALCULATIONS FOR 4G5/2 TO 6H7/2 TRANSITIONS IN SM3+-YAG SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID RARE-EARTH IONS; LANTHANUM TRIFLUORIDE; SM-YAG; FLUORESCENCE; ABSORPTION; PRESSURE AB A previously published analysis of the energy levels of Sm3+ in Y3Al5O12 (YAG) has been extended to include the 4G5/2 multiplet. New absorption and emission data are reported, and some previously reported levels have been reassigned. A theoretical calculation of intensities of emitted radiation originating at the 4G5/2 multiplet predicts that radiation emitted in transitions to the H-6(7/2) multiplet is particularly strong. The strongest transitions originate at the lowest of the three levels in the 4G5/2 multiplet. C1 USN,CTR WEAP,DEPT RES,DIV CHEM,CHINA LAKE,CA 93555. SAN JOSE STATE UNIV,DEPT PHYS,SAN JOSE,CA 95192. RP STEVENS, SB (reprint author), USA,LAB COMMAND,HARRY DIAMOND LABS,ADELPHI,MD 20783, USA. NR 12 TC 19 Z9 19 U1 1 U2 3 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JUL 15 PY 1991 VL 70 IS 2 BP 948 EP 953 DI 10.1063/1.349604 PG 6 WC Physics, Applied SC Physics GA FY341 UT WOS:A1991FY34100062 ER PT J AU HUDSON, TD WORCESTER, RK GREGORY, DA AF HUDSON, TD WORCESTER, RK GREGORY, DA TI PERFORMANCE-CHARACTERISTICS OF AN OPTICALLY ADDRESSED FERROELECTRIC LIQUID-CRYSTAL SPATIAL LIGHT-MODULATOR SO APPLIED OPTICS LA English DT Article DE OPTICAL PATTERN RECOGNITION; SPATIAL LIGHT MODULATORS; OPTICAL COMPUTING; CORRELATORS AB Key performance characteristics of an optically addressed ferroelectric liquid-crystal spatial light modulator have been measured and compare favorably with those of other commercially available spatial light modulators. Several characteristics that are important for optical pattern recognition, including imaging resolution, visibility, and response time, are discussed. Maximum resolution was measured to be 40 line pairs/mm at an imaging rate of 60 Hz. This differs from previously published results [Appl. Phys. Lett. 55, 537 (1989)], primarily because the device was operated so that good sensitivity was obtained with moderate illumination while the high resolution of the device was retained. RP HUDSON, TD (reprint author), USA,MISSILE COMMAND,AMSMI RD WS PO,REDSTONE ARSENAL,AL 35809, USA. NR 12 TC 13 Z9 15 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD JUL 10 PY 1991 VL 30 IS 20 BP 2867 EP 2872 PG 6 WC Optics SC Optics GA FW789 UT WOS:A1991FW78900007 PM 20706323 ER PT J AU STURM, M JOHNSON, JB AF STURM, M JOHNSON, JB TI NATURAL-CONVECTION IN THE SUB-ARCTIC SNOW COVER SO JOURNAL OF GEOPHYSICAL RESEARCH-SOLID EARTH AND PLANETS LA English DT Article ID RESONANT WAVELENGTH EXCITATION; SATURATED POROUS LAYER; THERMAL-CONVECTION; DRY SNOW; METAMORPHISM; AIR; GROWTH; VAPOR AB The purpose of this study was to determine if air convects in a natural snow cover. To detect convection, the temperature field in the subarctic snow cover in Fairbanks, Alaska, was measured hourly during three winters (1984-1987) using an array of thermistors which were suspended on threads and allowed to be buried by snowfall. The results indicate that convection occurred sporadically in 1984-1985 and almost continuously in 1985-1986 and 1986-1987. The evidence was (1) simultaneous warming and cooling at different locations in a horizontal plane in the snow, and (2) horizontal temperature gradients of up to 16-degrees-C m-1. During the winter, warm and cold zones developed in the snow and remained relatively fixed in space. We interpret these zones to be the result of a diffuse plumelike convection pattern linked to spatial variations in the temperature of the snow-soil interface. Air flow was inferred to have been primarily horizontal near the base of the snow and vertical elsewhere. Calculated flow speeds were of the order of 0.2 mm s-1, with a maximum value of 2 mm s-1. The convective circulation was time-dependent, with perturbations such as high wind or rapid changes in air temperature triggering periods when horizontal temperature gradients were strongest, suggesting that these were also periods when the air flow was fastest. The coincidence of depth hoar crystals with horizontal c axes and the horizontal flow lines at the base of the snow suggests that convection may have affected crystal growth directions. C1 US COLD REG RES & ENGN LAB,HANOVER,NH. RP STURM, M (reprint author), US COLD REG RES & ENGN LAB,BLDG 4070,FT WAINWRIGHT,AK 99703, USA. NR 58 TC 66 Z9 66 U1 0 U2 11 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0148-0227 J9 J GEOPHYS RES-SOLID PD JUL 10 PY 1991 VL 96 IS B7 BP 11657 EP 11671 DI 10.1029/91JB00895 PG 15 WC Geosciences, Multidisciplinary SC Geology GA FW819 UT WOS:A1991FW81900002 ER PT J AU LONI, A DELARUE, RM ZAVADA, JM WILSON, RG NOVAK, SW AF LONI, A DELARUE, RM ZAVADA, JM WILSON, RG NOVAK, SW TI DIRECT COMPARISON OF HYDROGEN DEPTH DISTRIBUTIONS AND REFRACTIVE-INDEX PROFILES IN ANNEALED PROTON-EXCHANGED Z-CUT LINBO3 WAVE-GUIDES SO ELECTRONICS LETTERS LA English DT Article DE WAVE-GUIDES; INTEGRATED OPTICS ID WAVE-GUIDES AB For the first time, to the authors' knowledge, hydrogen distributions in weakly and strongly annealed proton-exchanged z-cut LiNbO3 have been measured using modified secondary ion mass spectrometry and correlated with refractive index profiles determined by optical waveguide measurements. C1 UNIV GLASGOW,DEPT ELECTR & ELECT ENGN,GLASGOW G12 8QQ,SCOTLAND. USA,RES OFF,RES TRIANGLE PK,NC 27709. HUGHES RES LABS,MALIBU,CA 90265. CHARLES EVANS & ASSOCIATES,REDWOOD CITY,CA 94063. RP LONI, A (reprint author), BT&D TECHNOL,WHITEHOUSE RD,IPSWICH IP1 5PB,SUFFOLK,ENGLAND. RI De La Rue, Richard/A-8202-2012 NR 7 TC 15 Z9 15 U1 0 U2 0 PU IEE-INST ELEC ENG PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD, ENGLAND SG1 2AY SN 0013-5194 J9 ELECTRON LETT JI Electron. Lett. PD JUL 4 PY 1991 VL 27 IS 14 BP 1245 EP 1247 DI 10.1049/el:19910780 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA FW606 UT WOS:A1991FW60600015 ER PT J AU ELIASSON, AH PHILLIPS, YY AF ELIASSON, AH PHILLIPS, YY TI TREATMENT OF LYMPHANGIOLEIOMYOMATOSIS SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter ID TAMOXIFEN; LYMPHANGIOMYOMATOSIS C1 VET AFFAIRS MED CTR,AUGUSTA,GA 30910. RP ELIASSON, AH (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD JUL 4 PY 1991 VL 325 IS 1 BP 63 EP 63 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA FU342 UT WOS:A1991FU34200020 ER PT J AU MACDOUGALL, JD GREEN, HJ SUTTON, JR COATES, G CYMERMAN, A YOUNG, P HOUSTON, CS AF MACDOUGALL, JD GREEN, HJ SUTTON, JR COATES, G CYMERMAN, A YOUNG, P HOUSTON, CS TI OPERATION EVEREST-II - STRUCTURAL ADAPTATIONS IN SKELETAL-MUSCLE IN RESPONSE TO EXTREME SIMULATED ALTITUDE SO ACTA PHYSIOLOGICA SCANDINAVICA LA English DT Article DE CAPILLARIZATION; HYPOBARIC HYPOXIA; MUSCLE ULTRASTRUCTURE ID MYOGLOBIN; EXPOSURE; EXERCISE; HYPOXIA; MEN AB Alterations in skeletal muscle structure were investigated in 6 male subjects who underwent 40 days of progressive decompression in a hypobaric chamber simulating an ascent to the summit of Mount Everest. Needle biopsies were obtained from vastus lateralis of 5 subjects before and immediately after confinement in the chamber, and were examined for various structural and ultrastructural parameters. In addition, total muscle area was calculated in 6 subjects from CT scans of the thighs and upper arms. Muscle area at these sites was found to decrease significantly (by 13 and 15%) as a result of the hypobaric confinement. This was substantiated by significant (25%) decreases in cross sectional fibre areas of the Type I fibres and 26% decreases (non significant) in Type II fibre area. Capillary to fibre ratios remained unchanged following hypoxia as did capillary density although there was a trend (non significant) towards an increase in capillary density. There were no significant increases in mitochondrial volume density or other morphometric parameters. These data indicate that chronic, severe hypoxia on its own does not result in an increase in absolute muscle capillary number or a de novo synthesis of mitochondria. The trends toward an increase in capillary density and mitochondrial volume density were interpreted as being secondary occurrences in response to the pronounced muscle atrophy which occurred. C1 MCMASTER UNIV,DEPT MED,HAMILTON L8S 4K1,ONTARIO,CANADA. USA,ENVIRONM MED RES INST,DIV ALTITUDE RES,NATICK,MA 01760. UNIV WATERLOO,DEPT KINESIOL,WATERLOO N2L 3G1,ONTARIO,CANADA. RP MACDOUGALL, JD (reprint author), MCMASTER UNIV,DEPT PHYS EDUC,HAMILTON L8S 4K1,ONTARIO,CANADA. NR 32 TC 79 Z9 79 U1 0 U2 5 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0001-6772 J9 ACTA PHYSIOL SCAND JI Acta Physiol. Scand. PD JUL PY 1991 VL 142 IS 3 BP 421 EP 427 DI 10.1111/j.1748-1716.1991.tb09176.x PG 7 WC Physiology SC Physiology GA FW275 UT WOS:A1991FW27500016 PM 1927554 ER PT J AU GAITHER, NS ROGAN, KM STAJDUHAR, K BANKS, AK HULL, RW WHITSITT, T VERNALIS, MN AF GAITHER, NS ROGAN, KM STAJDUHAR, K BANKS, AK HULL, RW WHITSITT, T VERNALIS, MN TI ANOMALOUS ORIGIN AND COURSE OF CORONARY-ARTERIES IN ADULTS - IDENTIFICATION AND IMPROVED IMAGING UTILIZING TRANSESOPHAGEAL ECHOCARDIOGRAPHY SO AMERICAN HEART JOURNAL LA English DT Article ID DOPPLER ECHOCARDIOGRAPHY; SUDDEN-DEATH; VISUALIZATION; VALSALVA; SINUS AB Anomalous origin of a coronary artery is rare, but may represent a clinically significant abnormality, since some anomalies are associated with myocardial ischemia, infarction, and sudden death. Diagnosis may elude routine screening procedures, and even when an anomalous vessel is identified angiographically, it may be difficult to delineate its true course on the basis of angiography alone. The purpose of this study was to determine whether transesophageal echocardiography (TEE) is of value in making the diagnosis and outlining the course of anomalous coronary arteries. Five adult patients with anomalous origin of a coronary artery were studied by monoplane TEE and selective coronary angiography. Transthoracic echocardiography (TTE) was also performed in four of these five patients. Anomalous coronary ostia were visualized in four of five patients utilizing TEE, but in none of four patients by TTE. A proximal segment of the anomalous coronary vessel was identified in all five patients by TEE, and in only two of four patients by TEE. TEE images were consistently of superior diagnostic quality. TEE is a valuable tool for the echocardiographic identification of anomalous coronary arteries, and is superior to TTE in adult patients. C1 DWIGHT D EISENHOWER ARMY MED CTR,FT GORDON,GA 30905. RP GAITHER, NS (reprint author), WALTER REED ARMY MED CTR,CARDIOL SERV,WASHINGTON,DC 20307, USA. NR 23 TC 54 Z9 55 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0002-8703 J9 AM HEART J JI Am. Heart J. PD JUL PY 1991 VL 122 IS 1 BP 69 EP 75 DI 10.1016/0002-8703(91)90760-F PN 1 PG 7 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA FV115 UT WOS:A1991FV11500011 PM 2063765 ER PT J AU WALL, SG AF WALL, SG TI TREATMENT OF A DEAF MULTIPLE PERSONALITY-DISORDER SO AMERICAN JOURNAL OF CLINICAL HYPNOSIS LA English DT Letter RP WALL, SG (reprint author), TRIPLER ARMY MED CTR,MED CORPS,HONOLULU,HI 96859, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLIN HYPNOSIS PI DES PLAINES PA 2200 EAST DEVON AVE SUITE 291, DES PLAINES, IL 60018 SN 0002-9157 J9 AM J CLIN HYPN JI Am. J. Clin. Hypn. PD JUL PY 1991 VL 34 IS 1 BP 68 EP 69 PG 2 WC Psychology, Clinical SC Psychology GA FV272 UT WOS:A1991FV27200010 PM 1789880 ER PT J AU ROSCELLI, JD AF ROSCELLI, JD TI THE H IN HEMORRHAGIC-SHOCK AND ENCEPHALOPATHY SYNDROME SO AMERICAN JOURNAL OF DISEASES OF CHILDREN LA English DT Letter RP ROSCELLI, JD (reprint author), TRIPLER ARMY MED CTR,HONOLULU,HI 96859, USA. NR 2 TC 3 Z9 3 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0002-922X J9 AM J DIS CHILD JI Am. J. Dis. Child. PD JUL PY 1991 VL 145 IS 7 BP 720 EP 721 PG 2 WC Pediatrics SC Pediatrics GA FV108 UT WOS:A1991FV10800006 PM 2058597 ER PT J AU KAUSHAL, JN GOLDNER, F AF KAUSHAL, JN GOLDNER, F TI VALIDATION OF THE DIGITAL RECTAL EXAMINATION AS AN ESTIMATE OF ANAL-SPHINCTER SQUEEZE PRESSURE SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Article ID INCONTINENCE AB Although digital examination is commonly used to assess anal sphincter tone and maximal squeeze pressure, the accuracy of this test has never been adequately validated. A total of 27 patients with a spectrum of subjectively assessed anal sphincter tones were studied. Simultaneous subjective (digital) and objective (manometric) determinations of maximal anal squeeze pressures were made. Subjective digital assessment revealed the following: three patients, absent squeeze pressure (grade 0); two patients, markedly reduced (grade + 1); six patients, reduced (grade + 2); and the remaining 16 patients had normal maximal squeeze pressure (grade + 3). Simultaneous objective anal sphincter pressure measurements, when compared with these subjective values, revealed a correlation coefficient of 0.97 (p < 0.05). Therefore, the clinician can reliably use the digital rectal examination to judge anal sphincter strength. C1 BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,SAN ANTONIO,TX. NR 10 TC 11 Z9 12 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD JUL PY 1991 VL 86 IS 7 BP 886 EP 887 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA FV532 UT WOS:A1991FV53200019 PM 2058632 ER PT J AU TRUWIT, CL DENARO, CP LAKE, JR DEMARCO, T AF TRUWIT, CL DENARO, CP LAKE, JR DEMARCO, T TI MR IMAGING OF REVERSIBLE CYCLOSPORINE-A-INDUCED NEUROTOXICITY SO AMERICAN JOURNAL OF NEURORADIOLOGY LA English DT Article ID NERVOUS-SYSTEM TOXICITY; HYPERTENSIVE ENCEPHALOPATHY; CORTICAL BLINDNESS; ENDOTHELIN; TRANSPLANTATION; CONVULSIONS; METHYLPREDNISOLONE; CHOLESTEROL; SEIZURES; PEPTIDE AB Neurotoxicity is a recognized complication of cyclosporin A (CsA) therapy in patients undergoing organ transplantation. It is most commonly manifested by fever, seizures, and altered mental status. Cortical blindness and speech and motor disturbances can also occur. Changes seen in cerebral white matter on imaging studies are nonenhancing areas of hypoattenuation on CT and T2 prolongation on MR. We report three cases of CsA-induced neurotoxicity in which reversible changes were observed in the cerebral white matter. In the first patient, CsA neurotoxicity occurred 1 week following orthotopic liver transplantation. In the second patient, CsA neurotoxicity coincided with an episode of severe systemic hypertension 4 weeks after cardiac transplantation. The third patient experienced seizures 1 month after heart/lung transplantation for cystic fibrosis. A current theory postulates a relationship between diminished serum cholesterol and CsA neurotoxicity. This theory, however, does not satisfactorily address all cases of CsA neurotoxicity. In particular, serum cholesterol measurements were normal in cases 2 and 3 and probably were normal in case 1, despite diminished cholesterol levels preoperatively. Although the matter of CsA-induced neurotoxicity remains unresolved, we suggest that endothelin, a newly described neuropeptide that causes intense vasoconstriction and that has been implicated in cerebral vasospasm, may potentiate CsA-induced damage to endothelium and promote CsA neurotoxicity. C1 UNIV CALIF SAN FRANCISCO,DIV CLIN PHARMACOL & EXPTL THERAPEUT,SAN FRANCISCO,CA 94143. UNIV CALIF SAN FRANCISCO,DEPT MED,LIVER TRANSPLANTAT SERV,SAN FRANCISCO,CA 94143. UNIV CALIF SAN FRANCISCO,DEPT MED,CARDIAC TRANSPLANTAT SERV,SAN FRANCISCO,CA 94143. UNIV CALIF SAN FRANCISCO,DEPT RADIOL,NEURORADIOL SECT,SAN FRANCISCO,CA 94143. USA,ACAD HLTH SCI,DEPT MED,FT SAM HOUSTON,TX 78234. NR 33 TC 175 Z9 179 U1 0 U2 0 PU AMER SOC NEURORADIOLOGY PI OAK BROOK PA 2210 MIDWEST RD, OAK BROOK, IL 60521 SN 0195-6108 J9 AM J NEURORADIOL JI Am. J. Neuroradiol. PD JUL-AUG PY 1991 VL 12 IS 4 BP 651 EP 659 PG 9 WC Clinical Neurology; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA FU351 UT WOS:A1991FU35100010 PM 1882738 ER PT J AU BENEDIKT, RA BROWN, DC ROTH, MK GEYER, CA GHAED, VN AF BENEDIKT, RA BROWN, DC ROTH, MK GEYER, CA GHAED, VN TI SPONTANEOUS DRAINAGE OF AN ETHMOIDAL MUCOCELE - A POSSIBLE CAUSE OF PNEUMOSINUS DILATANS SO AMERICAN JOURNAL OF NEURORADIOLOGY LA English DT Article ID MAXILLARY SINUS; SPHENOID SINUS; PNEUMOCELE C1 UNIFORMED SERV UNIV HLTH SCI,DEPT RADIOL & NUCL MED,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT OTOLARYNGOL HEAD & NECK SURG,WASHINGTON,DC 20307. RP BENEDIKT, RA (reprint author), WALTER REED ARMY MED CTR,DEPT RADIOL,6900 GEORGIA AVE,WASHINGTON,DC 20307, USA. NR 14 TC 18 Z9 18 U1 0 U2 0 PU AMER SOC NEURORADIOLOGY PI OAK BROOK PA 2210 MIDWEST RD, OAK BROOK, IL 60521 SN 0195-6108 J9 AM J NEURORADIOL JI Am. J. Neuroradiol. PD JUL-AUG PY 1991 VL 12 IS 4 BP 729 EP 731 PG 3 WC Clinical Neurology; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA FU351 UT WOS:A1991FU35100028 PM 1882754 ER PT J AU KRASNEY, JA CARROLL, M KRASNEY, E IWAMOTO, J CLAYBAUGH, JR HONG, SK AF KRASNEY, JA CARROLL, M KRASNEY, E IWAMOTO, J CLAYBAUGH, JR HONG, SK TI RENAL, HORMONAL, AND FLUID SHIFT RESPONSES TO ANP DURING HEAD-OUT WATER IMMERSION IN AWAKE DOGS SO AMERICAN JOURNAL OF PHYSIOLOGY LA English DT Article DE CAPILLARY PRESSURE; HEMATOCRIT; ARGININE VASOPRESSIN; PLASMA RENIN ACTIVITY; URINE FLOW; SODIUM EXCRETION; ARTERIAL PRESSURE; HEART RATE; CENTRAL VENOUS PRESSURE; VOLUME EXPANSION ID ATRIAL NATRIURETIC FACTOR; CONSCIOUS DOGS; VASOPRESSIN; PEPTIDE; RELEASE; PLASMA; ATRIOPEPTIN; INHIBITION; EXCRETION; PRESSURE AB Renal responses to low doses of atrial natriuretic peptide (ANP) may be potentiated during water immersion-induced central hypervolemia. To test this hypothesis, ANP was infused in awake dogs in doses of 0, 5, and 25 ng.kg-1.min-1 either when the dogs were in air or during head-out water immersion (WI) under thermoneutral conditions (37-degrees-C). In general, there were greater diuretic (V) and natriuretic responses (U(Na)V) at the same level of plasma ANP in WI, with the slopes (or sensitivities) of V and U(Na)V in relation to plasma ANP levels being significantly increased during WI. Plasma renin activity decreased only during WI and was significantly correlated with both V and U(Na)V only during WI. Plasma and urinary arginine vasopressin levels were unchanged during WI. Infusion of ANP prevented the usual decline of hematocrit that occurs during WI. These results support the view that the renal sensitivity to ANP is augmented during the plasma volume expansion of WI. In addition, ANP may attenuate the transcapillary fluid shift that occurs during WI. C1 TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96859. RP KRASNEY, JA (reprint author), SUNY BUFFALO,SCH MED & BIOMED SCI,DEPT PHYSIOL,124 SHERMAN HALL,BUFFALO,NY 14214, USA. FU NHLBI NIH HHS [P0-1 HL-28542] NR 28 TC 4 Z9 4 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0002-9513 J9 AM J PHYSIOL JI Am. J. Physiol. PD JUL PY 1991 VL 261 IS 1 BP R188 EP R197 PN 2 PG 10 WC Physiology SC Physiology GA FY357 UT WOS:A1991FY35700065 PM 1830460 ER PT J AU GARDNER, LI AF GARDNER, LI TI SUBSTANCE-ABUSE IN MILITARY PERSONNEL - BETTER OR WORSE SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Editorial Material ID STATES RP GARDNER, LI (reprint author), USA,WALTER REED MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307, USA. NR 8 TC 1 Z9 1 U1 0 U2 0 PU AMER PUBLIC HEALTH ASSN INC PI WASHINGTON PA 1015 FIFTEENTH ST NW, WASHINGTON, DC 20005 SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JUL PY 1991 VL 81 IS 7 BP 837 EP 838 DI 10.2105/AJPH.81.7.837 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA GD161 UT WOS:A1991GD16100002 PM 2053655 ER PT J AU MONATH, TP AF MONATH, TP TI YELLOW-FEVER - VICTOR, VICTORIA - CONQUEROR, CONQUEST - EPIDEMICS AND RESEARCH IN THE LAST 40 YEARS AND PROSPECTS FOR THE FUTURE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID MONOCLONAL-ANTIBODIES; VIRUS; NIGERIA; ARBOVIRUS; STRAINS RP MONATH, TP (reprint author), USA,MED RES INST INFECT DIS,DIV VIROL,FT DETRICK,FREDERICK,MD 21702, USA. NR 48 TC 54 Z9 54 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 1991 VL 45 IS 1 BP 1 EP 43 PG 43 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA GC824 UT WOS:A1991GC82400001 PM 1867343 ER PT J AU GORDON, DM DAVIS, DR LEE, M LAMBROS, C HARRISON, BA SAMUEL, R CAMPBELL, GH JEGATHESAN, M SELVARAJAN, K LEWIS, GE AF GORDON, DM DAVIS, DR LEE, M LAMBROS, C HARRISON, BA SAMUEL, R CAMPBELL, GH JEGATHESAN, M SELVARAJAN, K LEWIS, GE TI SIGNIFICANCE OF CIRCUMSPOROZOITE-SPECIFIC ANTIBODY IN THE NATURAL TRANSMISSION OF PLASMODIUM-FALCIPARUM, PLASMODIUM-VIVAX, AND PLASMODIUM-MALARIAE IN AN ABORIGINAL (ORANG-ASLI) POPULATION OF CENTRAL PENINSULAR MALAYSIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID NATURALLY ACQUIRED ANTIBODIES; CD8+ T-CELLS; IMMUNODOMINANT EPITOPE; SPOROZOITE VACCINE; ESCHERICHIA-COLI; PROTEIN; IMMUNITY; IMMUNOGENICITY; SAFETY; GENE AB Two hundred and seventy-five Orang Asli volunteers living in nine villages in the Pos Legap Valley of Perak State, penisular Malaysia, participated in a prospective study designed to characterize the epidemiological, parasitological, and entomological characteristics of Plasmodium falciparum, P. vivax, and P. malariae malaria transmission. Prevalence rates for the three plasmodial species at initiation of the study ranged from 56% in the 0-4-year-old age group to 0% in individuals over the age of 40. Entomological surveys were conducted, enabling us to determine mosquito salivary gland-positive rates and entomological inoculation rates of 1.2 infectious mosquito bites per person per month for P. falciparum, 2.4 for P. vivax, and 0.3 for P. malariae. Cumulative incidence rates over the 16 weeks of the study, following radical cure of all volunteers, were 22.5% for P. falciparum, 12.7% for P. vivax, and 1.5% for P. malariae. The median baseline antibody titer against the immunodominant repetitive B cell epitope of P. falciparum or P. vivax circumsporozoite protein was significantly higher for volunteers who did not become parasitemic. Volunteers were selected for further study if they had evidence of being challenged with P. falciparum sporozoites during the study, based on a two-fold or greater increase in antibody titer against the immunodominant repetitive B cell epitope of the circumsporozoite protein. Resistance to infection was seen in six of 10 individuals who had high (> 25 OD units) baseline ELISA titers, compared with only three of 24 individuals who had low baseline ELISA titers (chi-2 P < 0.02). A similar analysis for P. vivax did not show a significant correlation. C1 USA,INST MED RES,MED RES UNIT,KUALA LUMPUR,MALAYSIA. CTR DIS CONTROL,CTR INFECT DIS,DIV PARASIT DIS,ATLANTA,GA 30333. INST MED RES,KUALA LUMPUR,MALAYSIA. GOMBAK HOSP,DEPT ORANG ASLI AFFAIRS,SELANGOR,MALAYSIA. RP GORDON, DM (reprint author), WALTER REED ARMY MED CTR,DEPT IMMUNOL,WASHINGTON,DC 20307, USA. NR 21 TC 16 Z9 17 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 1991 VL 45 IS 1 BP 49 EP 56 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA GC824 UT WOS:A1991GC82400003 PM 1867348 ER PT J AU GUDERIAN, RH CHICO, ME ROGERS, MD PATTISHALL, KM GROGL, M BERMAN, JD AF GUDERIAN, RH CHICO, ME ROGERS, MD PATTISHALL, KM GROGL, M BERMAN, JD TI PLACEBO CONTROLLED TREATMENT OF ECUADORIAN CUTANEOUS LEISHMANIASIS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID VISCERAL LEISHMANIASIS; PLUS ALLOPURINOL; COMBINATION; EFFICACY AB Pentavalent antimony has been considered to be the standard treatment for leishmaniasis, but more recently, the orally administrable agent allopurinol ribonucleoside has been the subject of several clinical trials. In this study, these two agents were evaluated in patients with Ecuadorian cutaneous leishmaniasis. Patients were randomly assigned to the two treatment groups. The mean reduction in lesion size for the 28 patients treated with Pentostam (20 mg Sb/kg/day intramuscularly for 20 days) was 61%, 23%, and 11% after one, two, and three weeks, respectively. There was a wide range in the individual values, and some lesions markedly enlarged in the first week of therapy. An initially healed lesion was defined as one that had > 80% re-epithelialized by the 1.5-month post-treatment followup. All Pentostam patients demonstrated this degree of lesion resolution (100% initial healing rate), but one patient showed evidence of relapse at the three month followup resulting in a 96% complete healing rate for the 12 month observation period. Patients in the untreated control group demonstrated a strikingly high rate of healing with 9 of 12 patients having re-epithelialized all lesions after 1.5 months observation (75% initial healing rate). The mean reduction in lesion size for the untreated patients was 56%, 29%, and 25% after one, two, and three weeks, respectively. Twenty-one patients received allopurinol ribonucleoside (1,500 mg QID) plus probenecid (500 mg QID) for 28 days. Lesions in nine of these patients were healed at the time of the 1.5 month followup (41% healing rate). It is clear that a low self-healing rate in South American cutaneous leishmaniasis can not be assumed, and that studies on potentially new therapeutic regimens will require observations on untreated patients with similar lesions. The wide range of clinical response after 1-2 weeks of treatment or observation, with lesions that ultimately heal, has not been previously unreported, and should be valuable information for clinicians who manage individual cases. The results of this and other reports on the use of allopurinol and its ribonucleoside in the treatment of leishmaniasis are critically reviewed. C1 BURROUGHS WELLCOME CO,RES TRIANGLE PK,NC 27709. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP GUDERIAN, RH (reprint author), CENT UNIV ECUADOR,SCH MED,HCJB,CASILLA 691,QUITO,ECUADOR. NR 13 TC 39 Z9 42 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 1991 VL 45 IS 1 BP 92 EP 97 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA GC824 UT WOS:A1991GC82400008 PM 1651060 ER PT J AU GROGL, M MARTIN, RK ODUOLA, AMJ MILHOUS, WK KYLE, DE AF GROGL, M MARTIN, RK ODUOLA, AMJ MILHOUS, WK KYLE, DE TI CHARACTERISTICS OF MULTIDRUG RESISTANCE IN PLASMODIUM AND LEISHMANIA - DETECTION OF P-GLYCOPROTEIN-LIKE COMPONENTS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID MAMMALIAN-CELL LINES; CHLOROQUINE RESISTANCE; MEMBRANE-VESICLES; DRUG-RESISTANCE; FALCIPARUM; GENE; INVITRO; VINBLASTINE; EXPRESSION; AMPLIFICATION AB Multidrug-resistance (MDR) in neoplastic cells is frequently characterized by the overexpression of P-glycoprotein (PGP), a 170 kDa transmembrane glycoprotein that binds multiple cytotoxic drugs as well as calcium channel antagonists. Chloroquine resistance in Plasmodium falciparum appears to be analogous to MDR in neoplastic cells, where the induction of resistance with one drug confers resistance to other structurally and functionally unrelated drugs. To test the hypothesis that chloroquine resistance in P. falciparum and antimony resistance in Leishmania is mediated by a similar mechanism of MDR in mammalian neoplastic cells, a PGP-specific monoclonal antibody (C219) was used to determine the presence of PGP genes in resistant and sensitive Plasmodium and Leishmania parasites by indirect immunofluorescence assays and Western blotting procedures. These PGP-like components were detected in both drug-sensitive and -resistant Plasmodium and Leishmania cells. A 40-42 kDa component was observed to be greater in a chloroquine-resistant P. berghei (C line) than in a chloroquine-susceptible P line. Differences observed between Pentostam-resistant and -sensitive Leishmania promastigote clones and isolates included the increased expression of 96-106 and 23-25 kDa peptides in drug-resistant L. enriettii, and increased amounts of two different peptides in two drug-resistant L. panamensis clones (i.e., 96-106 and 43-45 kDa in WR-746-CL4, and 53 and 23-25 kDa in WR-746-CL6). Interestingly, C219 detected a peptide of the same molecular weight (170 kDa) in amastigotes as in MDR KB carcinoma cells (KB-V1). Comparative indirect immunofluorescent studies suggested that a correlation existed between the degree of antimony susceptibility and the concentration of the moiety recognized by C219 in two L. panamensis clones. Binding of the C219 monoclonal antibody to the PGP-like component of Leishmania was blocked by Pentostam, while the binding of C219 to multiple-drug resistant KB-V1 PGP was not inhibited by Pentostam, regardless of the PGP concentration. This suggests some degree of specificity in the binding of Pentostam to the Leishmania PGP-like components. In addition, these studies have demonstrated that drug-sensitive Leishmania accumulate two to five times more Sb-125-Pentostam than resistant clones. RP GROGL, M (reprint author), WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,LEISHMANIA SECT,BLDG 500,WASHINGTON,DC 20307, USA. NR 40 TC 40 Z9 42 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 1991 VL 45 IS 1 BP 98 EP 111 PG 14 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA GC824 UT WOS:A1991GC82400009 PM 1678253 ER PT J AU MUNDIE, TG JANUSZKIEWICZ, AJ RAYBURN, DB MARTIN, DG RIPPLE, GR AF MUNDIE, TG JANUSZKIEWICZ, AJ RAYBURN, DB MARTIN, DG RIPPLE, GR TI EFFECTS OF CONDITIONING AND MAXIMAL INCREMENTAL EXERCISE ON OXYGEN-CONSUMPTION IN SHEEP SO AMERICAN JOURNAL OF VETERINARY RESEARCH LA English DT Article ID TREADMILL; RESPONSES; HYPOXIA; FLOW AB To assess the suitability of sheep for exercise studies, the effect of incremental exercise and conditioning on oxygen consumption (V(O2) was studied. Six sheep were adapted to a treadmill and subsequently trained 8 weeks. The sheep were then studied, in random order, using 3 incremental exercise protocols (EX-1, EX-2, and EX-3). The protocols were chosen to approximate high (EX-1), moderate (EX-2), and low (EX-3) intensity exercise by varying treadmill speed and incline. The sheep were then conditioned for an additional 12 weeks and retested on the EX-2 protocol. During exercise, V(O2), gas exchange ratio (R), and rectal temperatures (T(b)) were recorded. All 3 protocols resulted in significant increases in V(O2), R, and T(b) (P < 0.05). Maximum V(O2) for EX-1, 49.9 +/- 5.0 ml/min/kg of body weight, was significantly greater than maximum V(O2) for EX-2 and EX-3, 37.8 +/- 6.5 and 42.3 +/- 6.0 ml/min/kg, respectively (P < 0.05), whereas maximum R and maximum T(b) were similar. After the additional 12-week conditioning, time on the treadmill increased 40% from 9.58 +/- 0.87 to 13.4 +/- 0.44 minutes, and maximum V(O2) increased 27% to 48.1 +/- 9.1 ml/min/kg. These data indicated that maximum V(O2) varied with intensity of the exercise, 12 weeks of maximal exercise conditioning was sufficient to produce a measurable training effect (ie, increase endurance and maximum oxygen consumption) and sheep are suitable for maximal exercise studies where V(O2) measurements are desired. C1 WALTER REED ARMY MED CTR,DIV MED,DEPT RESP RES,WASHINGTON,DC 20307. NR 22 TC 11 Z9 11 U1 0 U2 0 PU AMER VETERINARY MEDICAL ASSOC PI SCHAUMBURG PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 SN 0002-9645 J9 AM J VET RES JI Am. J. Vet. Res. PD JUL PY 1991 VL 52 IS 7 BP 1019 EP 1023 PG 5 WC Veterinary Sciences SC Veterinary Sciences GA FU182 UT WOS:A1991FU18200007 PM 1892256 ER PT J AU ABBRECHT, PH RAJAGOPAL, KR KYLE, RR AF ABBRECHT, PH RAJAGOPAL, KR KYLE, RR TI EXPIRATORY MUSCLE RECRUITMENT DURING INSPIRATORY FLOW-RESISTIVE LOADING AND EXERCISE SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Article ID RIB CAGE; VENTILATION; PRESSURE; HUMANS AB Both exercise and inspiratory flow-resistive loading may cause recruitment of expiratory muscles. To evaluate the extent of recruitment in combined exercise and flow-resistive loading, and to estimate the effect on inspiratory muscle work, we studied five men, 26 to 39 yr of age, during mild exercise with different degrees of inspiratory flow-resistive loading. Each subject performed four 1-h exercise runs at 30% of their maximal oxygen consumption on different days while inspiring through an external resistor of either 1.4, 14.5, 19.9, or 30.6 cm H2O/s/L. Mouth and esophageal pressure, inspiratory flow rate, and abdominal and rib cage motion were recorded continuously. Abdominal expansion tended to lead and rib cage expansion tended to lag the start of inspiration as judged from the beginning of negative pressure development at the mouth. These time differences increased as resistive load increased. Plots of abdominal versus rib cage motion also showed increase in phase shift, with the abdomen leading the rib cage on inspiration. For all subjects, the esophageal pressure at the end of expiration became less negative as the resistive load increased, indicating that the end-expiratory volume decreased with increasing resistive load. We conclude that there was increasing use of expiratory muscles as the resistive load increased, and that the initial expansion of the abdomen at high resistive loads represented elastic recoll of structures that had been compressed below the volume at FRC by the expiratory muscles. Calculations suggest that, at different resistive loads, from 10 to 20% of the work of inspiration was transferred to the expiratory muscles, and that the power of the inspiratory muscles approached a limiting value at high resistive loads. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PHYSIOL,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,PULM DIS SERV,WASHINGTON,DC 20307. RP ABBRECHT, PH (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814, USA. NR 25 TC 14 Z9 15 U1 0 U2 0 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD JUL PY 1991 VL 144 IS 1 BP 113 EP 120 PG 8 WC Respiratory System SC Respiratory System GA FW296 UT WOS:A1991FW29600021 PM 2064116 ER PT J AU MUSIO, F MOZINGO, D OTCHY, DP AF MUSIO, F MOZINGO, D OTCHY, DP TI MULTIPLE, GIANT FIBROADENOMA SO AMERICAN SURGEON LA English DT Article ID BREAST AB Multiple, giant fibroadenomas are histologic and clinical variants of "juvenile" or "giant" fibroadenomas. These tumors are rare and occur mainly in adolescent and young adult black females. The individual lesions are well encapsulated with a histologic pattern primarily of the "juvenile" type, although cases of the "adult" type have been reported. A high incidence of recurrence is noted upon local excision, although this may decrease as the patient becomes older. Management options include local excision with reconstruction, reduction mammoplasty, and simple mastectomy with reconstruction. A case is described of this condition with review of the literature. RP MUSIO, F (reprint author), BROOKE ARMY MED CTR,DEPT SURG,GEN SURG SERV,FT SAM HOUSTON,TX 78234, USA. NR 24 TC 20 Z9 20 U1 0 U2 0 PU SOUTHEASTERN SURGICAL CONGRESS PI ATLANTA PA 1776 PEACHTREE RD, NW., SUITE 410N, ATLANTA, GA 30309-2352 SN 0003-1348 J9 AM SURGEON JI Am. Surg. PD JUL PY 1991 VL 57 IS 7 BP 438 EP 441 PG 4 WC Surgery SC Surgery GA FW416 UT WOS:A1991FW41600007 PM 1647714 ER PT J AU JENKINS, TF MIYARES, PH AF JENKINS, TF MIYARES, PH TI NONEVAPORATIVE PRECONCENTRATION TECHNIQUE FOR VOLATILE AND SEMIVOLATILE SOLUTES IN CERTAIN POLAR-SOLVENTS SO ANALYTICAL CHEMISTRY LA English DT Note ID WATER PARTITION-COEFFICIENTS; SALTING-OUT RP JENKINS, TF (reprint author), USA,COLD REG RES & ENGN LAB,DIV RES,HANOVER,NH 03755, USA. NR 11 TC 12 Z9 12 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD JUL 1 PY 1991 VL 63 IS 13 BP 1341 EP 1343 DI 10.1021/ac00013a031 PG 3 WC Chemistry, Analytical SC Chemistry GA FV113 UT WOS:A1991FV11300033 ER PT J AU GRIMES, SR MEIN, CE TREVINO, S AF GRIMES, SR MEIN, CE TREVINO, S TI PREOPERATIVE ANTIBIOTIC AND POVIDONE-IODINE PREPARATION OF THE EYE SO ANNALS OF OPHTHALMOLOGY LA English DT Article ID OPHTHALMIC SURGERY; CHEMICAL PREPARATION; CONJUNCTIVA AB We compared gentamicin 0.3% one drop every three hours the night before and the morning of surgery ("half-day regimen") with the same drug one drop qid for three days ("three-day regimen") in 15 eyes undergoing intraocular surgery. Conjunctival cultures of both groups taken before povidone-iodine preparation showed mean colony counts of 3.67 +/- 0.82 in the half-day regimen versus 1.0 +/- 0.43 in the three-day regimen. Conjunctival cultures taken after the administration of a povidone-iodine 5% preparation showed 7.17 +/- 3.52 and 2.75 +/- 0.88, respectively, in the two groups. Although there was a statistical difference in colony counts, topical gentamicin 0.3% given the night before and day of surgery had comparable low colony counts with the three-day course. The 5% povidone-iodine solution was not effective in reducing bacterial flora although it did eliminate all fungal colonies. C1 BROOKE ARMY MED CTR,DEPT SURG,OPHTHALMOL SERV,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,AREA LAB SERV,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,DEPT PATHOL,FT SAM HOUSTON,TX 78234. NR 14 TC 23 Z9 24 U1 0 U2 0 PU AMER SOC CONTEMPORARY OPHTHALMOLOGY PI SKOKIE PA 4711 GOLF RD, SUITE 408, SKOKIE, IL 60076-1242 SN 0003-4886 J9 ANN OPHTHALMOL JI Ann. Ophthalmol. PD JUL PY 1991 VL 23 IS 7 BP 263 EP 266 PG 4 WC Ophthalmology SC Ophthalmology GA GA142 UT WOS:A1991GA14200005 PM 1929094 ER PT J AU WAGNER, RB SLIVKO, B JAMIESON, PM DILLS, MS EDWARDS, FH AF WAGNER, RB SLIVKO, B JAMIESON, PM DILLS, MS EDWARDS, FH TI EFFECT OF LUNG CONTUSION ON PULMONARY HEMODYNAMICS SO ANNALS OF THORACIC SURGERY LA English DT Article; Proceedings Paper CT 37TH ANNUAL MEETING OF THE SOUTHERN THORACIC SURGICAL ASSOC CY NOV 08-10, 1990 CL DORADO, PR SP SO THORAC SURG ASSOC ID HYPOXIC VASOCONSTRICTION; GAS-EXCHANGE; PERFUSION; INJURY; HYPERTENSION; INDOMETHACIN; INHALATION; PNEUMONIA; SHUNT; CHEST AB Our purpose was to examine changes in pulmonary hemodynamics for patients with pulmonary contusion. Pulmonary vascular resistance index (PVRI) and shunt fraction were calculated from standard measurements in 25 traumatized patients. The percent of lung volume injured, measured as air-space filling disease (ASF), was quantitated from computed tomograms using a previously described technique. The amount of reactive pulmonary vasoconstriction per unit of injury (PVRI/ASF) identified 3 groups of patients: 5 were reactors (PVRI/ASF > 15), 10 were weak-reactors (PVRI/ASF = 5 to 15), and 10 were nonreactors (PVRI/ASF < 5). In the reactor group PVRI increased as the size of contusion (ASF) increased (r = 0.99). In weak-reactors PVRI also increased with the size of contusion (r = 0.93), but the slope was less pronounced. In both groups shunt fraction did not rise above 0.31. In the nonreactors, PVRI remained normal while shunt fraction increased with the extent of injury (r = 0.95). These results indicate that pulmonary vasoconstriction often occurs after pulmonary contusion. The vasoconstriction most probably represents a compensatory mechanism to limit perfusion of traumatized parenchyma, thereby minimizing increases in shunt fraction. Some patients (nonreactors) not demonstrating this response have unchecked increases in shunt fraction. This insight into the hemodynamic sequelae of pulmonary contusions may enhance our ability to provide optimal care for patients suffering from this injury. C1 PRINCE GEORGES GEN HOSP & MED CTR,DEPT SURG,CHEVERLY,MD. WALTER REED ARMY MED CTR,DEPT THORAC SURG,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. PRINCE GEORGES GEN HOSP & MED CTR,DEPT INTENS CARE,CHEVERLY,MD. NR 25 TC 16 Z9 18 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0003-4975 J9 ANN THORAC SURG JI Ann. Thorac. Surg. PD JUL PY 1991 VL 52 IS 1 BP 51 EP 58 PG 8 WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery SC Cardiovascular System & Cardiology; Respiratory System; Surgery GA FX266 UT WOS:A1991FX26600011 PM 2069463 ER PT J AU ADLER, M PETRALI, JP MOORE, DH FILBERT, MG AF ADLER, M PETRALI, JP MOORE, DH FILBERT, MG TI FUNCTION AND DISTRIBUTION OF ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE IN CANINE TRACHEAL SMOOTH-MUSCLE SO ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE LA English DT Article ID FINE-STRUCTURE; INNERVATION; AIRWAY AB The total cholinesterase activity in canine tracheal smooth muscle was found to consist of butyrylcholinesterase and acetylcholinesterase in a ratio of 3:1. Most of the acetyl- and butyrylcholinesterase sites were distributed on the muscle surface; the remaining hydrolytic sites were associated with internal structures. Intracellular acetylcholinesterase staining was associated with the perinuclear envelope, sarcoplasmic reticulum and Golgi apparatus. Intracellular butyrylcholinesterase was associated with the perinuclear envelope, sarcoplasmic reticulum and the contractile filaments. Inhibition of acetylcholinesterase by the selective agent 1,5,bis(allyl-dimethylammoniumphenyl)-pentane-3-one dibromide (BW 284C51) led to a parallel leftward shift in the concentration-response curve for bath-applied acetylcholine. A similar shift was observed in the frequency-response curve for neurally released acetylcholine. Inhibition of butyrylcholinesterase by the selective agent tetraisopropyl-pyrophosphoramide potentiated the response to bath-applied and neurally released acetylcholine; the potentiation was limited to acetylcholine concentrations greater-than-or-equal-to 1-mu-M and frequencies greater-than-or-equal-to 10 Hz. It is concluded that both acetyl- and butyrylcholinesterase participate in the hydrolysis of acetylcholine in canine tracheal smooth muscle. The role of acetylcholinesterase is evident over the entire range of concentrations (1 nM to 100-mu-M) and frequencies (1 to 90 Hz) examined, whereas the role of butyrylcholinesterase is confined to the higher end of the concentration and frequency ranges used. C1 USA,MED RES INST CHEM DEF,DIV PATHOPHYSIOL,PATHOL BRANCH,ABERDEEN PROVING GROUND,MD 21010. RP ADLER, M (reprint author), USA,MED RES INST CHEM DEF,DIV PATHOPHYSIOL,NEUROTOXICOL BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 20 TC 9 Z9 9 U1 0 U2 2 PU ARCH INT PHARMACODYNAMIE PI GHENT PA DE PINTELAAN 185, B-9000 GHENT, BELGIUM SN 0003-9780 J9 ARCH INT PHARMACOD T JI Arch. Int. Pharmacodyn. Ther. PD JUL-AUG PY 1991 VL 312 BP 126 EP 139 PG 14 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA GT049 UT WOS:A1991GT04900010 PM 1722968 ER PT J AU SMITH, KJ DAVIS, C JAMES, WD SKELTON, HG ANGRITT, P AF SMITH, KJ DAVIS, C JAMES, WD SKELTON, HG ANGRITT, P TI ACYCLOVIR-RESISTANT VARICELLA ZOSTER RESPONSIVE TO FOSCARNET SO ARCHIVES OF DERMATOLOGY LA English DT Letter ID ACQUIRED-IMMUNODEFICIENCY-SYNDROME; HERPES-SIMPLEX VIRUS; PATIENT; INFECTION; THERAPY; AIDS C1 WILFORD HALL USAF MED CTR,LACKLAND AFB,TX 78236. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,DEPT DERMATOL,WASHINGTON,DC 20306. ARMED FORCES INST PATHOL,AIDS REGISTRY,WASHINGTON,DC 20306. RP SMITH, KJ (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 6 TC 30 Z9 30 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD JUL PY 1991 VL 127 IS 7 BP 1069 EP 1071 DI 10.1001/archderm.127.7.1069 PG 3 WC Dermatology SC Dermatology GA FW298 UT WOS:A1991FW29800031 PM 1648341 ER PT J AU DRABICK, JJ AF DRABICK, JJ TI IS THE INCREASED INCIDENCE OF LYMPHOMA IN VIETNAM VETERANS DUE TO AN UNDESCRIBED INFECTIOUS AGENT SO ARCHIVES OF INTERNAL MEDICINE LA English DT Letter RP DRABICK, JJ (reprint author), USA,WASHINGTON,DC 20310, USA. NR 4 TC 0 Z9 0 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD JUL PY 1991 VL 151 IS 7 BP 1462 EP 1463 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA FW295 UT WOS:A1991FW29500038 PM 2064506 ER PT J AU BLANK, S AF BLANK, S TI SOVIET PERSPECTIVES ON ASIAN SECURITY SO ASIAN SURVEY LA English DT Article RP BLANK, S (reprint author), USA,WAR COLL,CARLISLE,PA, USA. NR 33 TC 2 Z9 2 U1 0 U2 0 PU UNIV CALIF PRESS PI BERKELEY PA JOURNALS DEPT 2120 BERKELEY WAY, BERKELEY, CA 94720 SN 0004-4687 J9 ASIAN SURV JI Asian Surv. PD JUL PY 1991 VL 31 IS 7 BP 646 EP 661 DI 10.1525/as.1991.31.7.00p00747 PG 16 WC Area Studies SC Area Studies GA GD567 UT WOS:A1991GD56700005 ER PT J AU BUEHLER, DA MERSMANN, TJ FRASER, JD SEEGAR, JKD AF BUEHLER, DA MERSMANN, TJ FRASER, JD SEEGAR, JKD TI WINTER MICROCLIMATE OF BALD EAGLE ROOSTS ON THE NORTHERN CHESAPEAKE BAY SO AUK LA English DT Article ID SMALL BIRDS; TEMPERATURE; ENERGETICS AB From 11 November 1988 to 1 April 1989, we studied the microclimate and nightly energy budgets at three separate Bald Eagle (Haliaeetus leucocephalus) communal roost sites; one used in winter, one used in summer, and another used year-round. We compared the roost sites with the microclimate and nightly energy budgets at randomly selected inland forested sites and eagle shoreline perch sites on the northern Chesapeake Bay. Mean and minimum air temperatures were similar among all sites. Mean and maximum wind speeds were greater at the shore than at other sites. Wind speed did not differ between roosts and inland sites. Among roost sites, mean and maximum wind speeds were lowest at the winter roost. The year-round roost and summer-roost winds did not differ. Mean net radiation was greater at inland sites than at the shore sites, whereas mean net radiation of roost and inland and of roost and shore sites did not differ. Minimum net radiation was greatest at inland sites, whereas roost and shore minimum net radiation did not differ. We calculated that roosting eagles would have expended 205.9 kcal per night at traditional roost sites, 206.6 kcal per night at shoreline perches, and 203.7 kcal per night at inland sites. Calculated energy expended on the 10 coldest nights was similar among roost, shoreline, and inland sites. Adding the estimated cost of transport from shoreline perches to roosts (xBAR = 5.3 kcal/round trip) did not produce significant differences in nightly energy expenditure between eagles roosting in communal roosts vs. those roosting on the shore. C1 USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. RP BUEHLER, DA (reprint author), VIRGINIA POLYTECH INST & STATE UNIV,DEPT FISHERIES & WILDLIFE SCI,BLACKSBURG,VA 24061, USA. NR 18 TC 3 Z9 3 U1 0 U2 1 PU AMER ORNITHOLOGISTS UNION PI LAWRENCE PA ORNITHOLOGICAL SOC NORTH AMER PO BOX 1897, LAWRENCE, KS 66044-8897 SN 0004-8038 J9 AUK JI AUK PD JUL PY 1991 VL 108 IS 3 BP 612 EP 618 PG 7 WC Ornithology SC Zoology GA GB906 UT WOS:A1991GB90600014 ER PT J AU ARMSTRONG, LE SZLYK, PC SILS, IV DELUCA, JP OBRIEN, C HUBBARD, RW AF ARMSTRONG, LE SZLYK, PC SILS, IV DELUCA, JP OBRIEN, C HUBBARD, RW TI PREDICTION OF THE EXERCISE-HEAT TOLERANCE OF SOLDIERS WEARING PROTECTIVE OVERGARMENTS SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID MEN; INDEX; WORK; DRY AB The purpose of this investigation was to see whether subject characteristics and physiologic measurements predicted exercise-heat tolerance (EHT) and voluntary tolerance time in young soldiers. A total of 18 unacclimatized males attempted six 50-min periods of treadmill walking (4.0 km.h-1, 0% grade, 33-degrees-C db, 20 %rh) while wearing protective overgarments. Two post hoc groups of soldiers were defined: high EHT (H) and low EHT (L), having mean (+/- S.E.) tolerance times of 360 +/- 0 and 222 +/- 12 min, respectively. Significant (p < 0.05) H vs. L differences were observed in pretrial body mass, percent fat, and mass-to-surface area ratio (M/SA), as well as 170 min HR, Tsk and heat storage. The first three of these factors indicated that preexercise anthropomorphic characteristics may be used to distinguish H from L. The HR and Tsk differences were interpreted to mean that L experienced greater cardiovascular strain in protective overgarments because of a higher Tsk, which resulted in increased pooling of blood in cutaneous vessels, decreased cardiac filling pressure, and increased fatigue. Because HR variables were the strongest correlates of exercise tolerance time (r2 = 0.60 for HR at 170 min, r2 = 0.83 for time to reach HR of 160 beats.min-1) a novel HR monitoring technique was proposed which uses a wrist-mounted cardiotachometer to predict tolerance time. C1 USA,INST ENVIRONM MED,DIV HEAT RES,NATICK,MA 01760. RP ARMSTRONG, LE (reprint author), UNIV CONNECTICUT,CTR SPORTS,ROOM 223,U-110,2095 HILLSIDE RD,STORRS,CT 06269, USA. NR 26 TC 10 Z9 10 U1 0 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD JUL PY 1991 VL 62 IS 7 BP 673 EP 677 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA FU023 UT WOS:A1991FU02300013 PM 1898304 ER PT J AU GOUGE, SF MOORE, J ATKINS, F HIRSZEL, P CORY, MJ AF GOUGE, SF MOORE, J ATKINS, F HIRSZEL, P CORY, MJ TI RADIOCONTRAST REMOVAL BY DIALYSIS MEMBRANES SO BLOOD PURIFICATION LA English DT Article DE CONTRAST MEDIA; HEMODIALYSIS; HEMOFILTRATION ID NEPHROTOXICITY AB To examine the effect of membrane characteristics on radiocontrast mass transfer, we studied in vitro clearances with cuprophane and polyacrylonitrile (PAN) dialyzers and with polysulfone hemofilter. A perfusate of saline at 37-degrees-C, with 7.5 mmol/l (45 mg/dl) of urea and either Renografin (molecular weight 723) or Hexabrix (1405), was pumped through the blood path of dialyzers at 200 ml/min for 5 min. Each radiocontrast agent (RCA) and dialyzer was tested at 0, 150, and 250 or 300 mm Hg transmembrane pressure. In experiments with the use of hemofilter, clearances were tested at the perfusate flow of 50, 100 and 150 ml/min. RCAs were measured by fluorescent excitation analysis of iodine. Mean urea clearance was 16% higher in PAN than in cuprophane dialyzers. Clearance of RCAs was 1.5-3 times higher in PAN than cuprophane dialysers. With the latter, increases in transmembrane pressure resulted in a small amount of ultrafiltration (UF) and little increment in RCA clearance. With the former, increases in transmembrane pressure resulted in massive UF and remarkable increases in RCA clearance. Renografin clearance generally exceeded that of Hexabrix, which we attributed to Renografin's lower molecular weight. With the hemofilter, sieving coefficients were approximately 0.8 for each RCA. Yet, because of the lack of diffusive transport and a small surface area even at the highest perfusate flow rates, RCA clearance by the hemofilter was 20-50% less than that of cuprophane dialyzers. We conclude that PAN dialyzers are more efficient for RCA removal than cuprophane dialyzers or polysulfone hemofilters. C1 UNIFORMED SERV UNIV HLTH SCI,DIV NEPHROL,4301 JONES BRIDGE RD,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DIV NEPHROL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. NR 17 TC 13 Z9 13 U1 0 U2 1 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0253-5068 J9 BLOOD PURIFICAT JI Blood Purif. PD JUL-AUG PY 1991 VL 9 IS 4 BP 182 EP 187 DI 10.1159/000170016 PG 6 WC Hematology; Urology & Nephrology SC Hematology; Urology & Nephrology GA HN912 UT WOS:A1991HN91200002 PM 1818581 ER PT J AU LEVY, A STILLMAN, MJ RAUCH, TM AF LEVY, A STILLMAN, MJ RAUCH, TM TI CYCLO (HIS-PRO), D-AMPHETAMINE AND STRIATAL DOPAMINE - A MICRODIALYSIS STUDY SO BRAIN RESEARCH BULLETIN LA English DT Note DE CYCLO (HIS-PRO); DOPAMINE; MICRODIALYSIS; D-AMPHETAMINE; DOPAC; HVA ID INTRACEREBRAL DIALYSIS; INVIVO MICRODIALYSIS; RELEASE; INVITRO AB Extracellular levels of dopamine (DA) and its metabolites (DOPAC and HVA) were monitored in the striatum of rats using in vivo microdialysis, in an attempt to elucidate the mechanism of cyclo (His-Pro) (histidyl-proline-diketopiperazine, CHP) on dopaminergic activity. Pretreatment with CHP (0.5 mg/kg SC) (n = 5) or the equivalent volume of saline (n = 5) was followed 30 min later by 5 mg/kg IP of d-amphetamine. Dialysate samples were collected and analyzed by high performance liquid chromatography with electrochemical detection (HPLC-EC). Following the initial increase in DA caused by d-amphetamine, DA levels of CHP-treated rats were significantly lower than saline-treated rats across time (p < 0.05). No difference was observed for DOPAC or HVA. It is therefore unlikely that CHP interferes with the d-amphetamine-induced inhibition of DA reuptake. Other neurotransmitter systems may be involved in the CHP-induced augmentation of amphetamine's behavioral effects. Our data, as well as previous findings, suggest that attenuation of the dopaminergic response to d-amphetamine might be best explained on the basis of striatal DA depletion, possibly via tyrosine hydroxylase (TH) inhibition. This study also indicates that a dissociation may exist between the behavioral and the striatal DA response to acute amphetamine. The data support the hypothesis that amphetamine releases DA from a newly synthesized, extravesicular cytoplasmic pool, and that intracellular striatal DA is present in considerable excess relative to the extracellular DA. C1 USA,ENVIRONM MED RES INST,DIV MIL PERFORMANCE & NEUROSCI,SGRD UE OPS,KANSAS ST,NATICK,MA 01760. NR 21 TC 4 Z9 4 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0361-9230 J9 BRAIN RES BULL JI Brain Res. Bull. PD JUL PY 1991 VL 27 IS 1 BP 129 EP 131 DI 10.1016/0361-9230(91)90294-T PG 3 WC Neurosciences SC Neurosciences & Neurology GA GG702 UT WOS:A1991GG70200023 PM 1933425 ER PT J AU YOURICK, JJ EKLO, PA MCCLUSKEY, MP RAY, R AF YOURICK, JJ EKLO, PA MCCLUSKEY, MP RAY, R TI REGENERATION OF ACETYLCHOLINESTERASE IN CLONAL NEUROBLASTOMA-GLIOMA HYBRID NG108-15 CELLS AFTER SOMAN INHIBITION - EFFECT OF GLYCYL-L-GLUTAMINE SO CELL BIOLOGY AND TOXICOLOGY LA English DT Article DE ACETYLCHOLINESTERASE; NG108-15; SOMAN; ORGANOPHOSPHORUS; GLYCYL-L-GLUTAMINE; CELL CULTURE ID SUPERIOR CERVICAL-GANGLION; NEUROTROPHIC FACTOR; MOLECULAR-FORMS; CAT INVIVO; BUTYRYLCHOLINESTERASE; MAINTENANCE; SYSTEM; MUSCLE; ACID; RAT AB Acetylcholinesterase (AChE) in the clonal NG108-15 cell line has been previously characterized. This cell line represents an in vitro system to study AChE regulation and effects of chemical compounds that may alter AChE activity. Recently, glycyl-L-glutamine (GLG) was demonstrated to function as a neurotrophic factor for maintenance of AChE content in cat denervated superior cervical ganglion cells. In the present study, regeneration of AChE activity in cultures of undifferentiated NG108-15 cells after soman inhibition was investigated in the presence and absence of GLG. Cells were treated with soman (5.5 x 10(-6) M) for 15 min and then washed to remove excess soman. Culture medium containing either GLG (10(-6), 10(-5), or 10(-4) M) or glycyl-L-glutamic acid (10(-6) M) was added to cultures after soman treatment and remained in the medium until cell harvest. Cells were physically detached at various times after soman treatment and specific AChE activity was determined. After soman, AChE activity dramatically decreased to less than 1% of untreated cellular activity at 1 hr. AChE activity gradually increased after 5 hr, while untreated cell AChE activity was regained 20 hr after soman. The t1/2 for AChE regeneration was approximately 10 hr. GLG did not increase the rate of AChE regeneration after soman inhibition. These results indicate that GLG is not a directly acting neurotrophic factor for AChE synthesis in NG108-15 cells after chemical AChE inactivation. C1 USA,MED RES INST CHEM DEF BIOCHEM PHARMACOL BRANCH,ABERDEEN PROVING GROUND,MD 21010. RP YOURICK, JJ (reprint author), USA,MED RES INST CHEM DEF,APPL PHARMACOL BRANCH,SGRD UV PA,ABERDEEN PROVING GROUND,MD 21010, USA. NR 20 TC 1 Z9 1 U1 0 U2 3 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0742-2091 J9 CELL BIOL TOXICOL JI Cell Biol. Toxicol. PD JUL PY 1991 VL 7 IS 3 BP 229 EP 237 PG 9 WC Cell Biology; Toxicology SC Cell Biology; Toxicology GA GE204 UT WOS:A1991GE20400003 PM 1933514 ER PT J AU COWAN, FM BROOMFIELD, CA SMITH, WJ AF COWAN, FM BROOMFIELD, CA SMITH, WJ TI EFFECT OF SULFUR EXPOSURE ON PROTEASE ACTIVITY IN HUMAN PERIPHERAL-BLOOD LYMPHOCYTES SO CELL BIOLOGY AND TOXICOLOGY LA English DT Article DE SULFUR MUSTARD; PROTEASE; LYMPHOCYTES ID PLASMINOGEN-ACTIVATOR; MUSTARD; COLLAGENASE; INDUCTION AB Sulfur mustard is a chemical warfare blistering agent for which neither the mechanism of action nor an antidote is known. Papirmeister et al. (1985) have postulated a biochemical hypothesis for mustard-induced cutaneous injury involving a sequelae of DNA alkylation, metabolic disruption and activation of protease. Human peripheral blood lymphocytes in cell cultures were employed as an in vitro model for alkylating agent toxicity. A chromogenic peptide substrate assay was used for detection of protease in lymphocytes treated with sulfur mustard or chloroethyl ethyl sulfide. Exposure of human peripheral blood lymphocytes from normal donors to these alkylating agents resulted in an increase in cell associated protease activity. This increase in protease activity may contribute to the pathology or act as an indicator to predict methods of therapeutic intervention for sulfur mustard toxicity. C1 USA,MED RES INST CHEM DEF,BIOCHEM PHARMACOL BRANCH,SGRD UV PA,ABERDEEN PROVING GROUND,MD 21010. NR 29 TC 25 Z9 26 U1 0 U2 2 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0742-2091 J9 CELL BIOL TOXICOL JI Cell Biol. Toxicol. PD JUL PY 1991 VL 7 IS 3 BP 239 EP 248 PG 10 WC Cell Biology; Toxicology SC Cell Biology; Toxicology GA GE204 UT WOS:A1991GE20400004 PM 1933515 ER PT J AU BARCZAK, TM TASILLO, C GALLANT, WD AF BARCZAK, TM TASILLO, C GALLANT, WD TI EVALUATION OF WOOD PACKWALL SUPPORTS SO CIM BULLETIN LA English DT Article DE ROCK MECHANICS; PACKWALL SUPPORT; WOOD PACKWALL SUPPORT AB This paper describes the results of full-scale testing of several multi-layered wood crib configurations that were tested in the Bureau of Mines mine roof simulator in cooperation with the Cape Breton Coal Research Laboratory and Cape Breton Development Corporation of Sydney, Nova Scotia. Nine different crib configurations currently being used as wood packwall supports for advancing longwall applications in Canada were evaluated. Configuration parameters under study included the aspect ratio (height-to-width relationship) and percentage of solid material used in the crib construction. Test results and generalized wood crib behaviour are discussed in detail. Recommendations are made concerning crib constructions to maximize strength and stability. A cost benefit analysis of multi-layered wood crib configurations is made. A comparison of laboratory results and underground observations of several wood packwall supports in the Sydney coalfield suggest in situ load capacity is less than that measured in laboratory testing. Reasons for the apparent decrease of in situ load bearing capability are described. C1 CORPS ENGINEERS,PITTSBURGH,PA. CAPE BRETON COAL RES LAB,SYDNEY,NS,CANADA. RP BARCZAK, TM (reprint author), US BUR MINES,PITTSBURGH RES CTR,PITTSBURGH,PA 15236, USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU CANADIAN INST MINING METALLURGY PETROLEUM PI CALGARY PA 101 6TH AVE SW, STE 320, CALGARY AB TZP 3P4, CANADA SN 0317-0926 J9 CIM BULL JI CIM Bull. PD JUL PY 1991 VL 84 IS 951 BP 53 EP 57 PG 5 WC Metallurgy & Metallurgical Engineering; Mining & Mineral Processing SC Metallurgy & Metallurgical Engineering; Mining & Mineral Processing GA FY382 UT WOS:A1991FY38200010 ER PT J AU WULFSBERG, EA ZINTZ, EJ MOORE, JW AF WULFSBERG, EA ZINTZ, EJ MOORE, JW TI THE INHERITANCE OF CONOTRUNCAL MALFORMATIONS - A REVIEW AND REPORT OF 2 SIBLINGS WITH TETRALOGY OF FALLOT WITH PULMONARY ATRESIA SO CLINICAL GENETICS LA English DT Review DE CONGENITAL HEART DEFECTS; CONOTRUNCAL MALFORMATIONS; GENETIC COUNSELING; RECURRENCE RISK ID QUESTIONS AB Congenital heart defects (CHD) are a group of structural abnormalities that in humans have a combined incidence of approximately 1%. It is estimated that 4-5% of CHD are associated with chromosome abnormalities, 1-2% are associated with single gene syndromes, 1-2% are due to known teratogens, with the rest presumably determined multifactorially. We report on a brother and sister with tetralogy of Fallot with pulmonary atresia, and review the inheritance of familial conotruncal anomalies. We feel the small number of family clusters and the rare instances of consanguinity in non-syndromal conotruncal defects are consistent with multifactorial determination. While it is prudent in counseling families with 2 or more individuals with conotruncal CHD to raise the possibility of single gene inheritance, we believe that current empiric recurrence risk estimates most accurately reflect their risks. C1 WALTER REED ARMY MED CTR,PEDIAT CARDIOL,WASHINGTON,DC 20307. RP WULFSBERG, EA (reprint author), UNIFORMED SERV UNIV HLTH SCI,NATL NAVAL MED CTR,DEPT PEDIAT,BETHESDA,MD 20814, USA. NR 13 TC 14 Z9 15 U1 0 U2 0 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0009-9163 J9 CLIN GENET JI Clin. Genet. PD JUL PY 1991 VL 40 IS 1 BP 12 EP 16 PG 5 WC Genetics & Heredity SC Genetics & Heredity GA FV203 UT WOS:A1991FV20300003 PM 1884513 ER PT J AU ROTHBERG, JM AF ROTHBERG, JM TI BATTLE EXHAUSTION - SOLDIERS AND PSYCHIATRISTS IN THE CANADIAN-ARMY, 1939-1945 - COPP,T, MCANDREW,B SO CONTEMPORARY SOCIOLOGY-A JOURNAL OF REVIEWS LA English DT Book Review RP ROTHBERG, JM (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER SOCIOLOGICAL ASSOC PI WASHINGTON PA 1722 N ST NW, WASHINGTON, DC 20036-2981 SN 0094-3061 J9 CONTEMP SOCIOL JI Contemp. Sociol.-J. Rev. PD JUL PY 1991 VL 20 IS 4 BP 618 EP 619 DI 10.2307/2071866 PG 2 WC Sociology SC Sociology GA FX142 UT WOS:A1991FX14200096 ER PT J AU MICHAEL, NL BURKE, DS AF MICHAEL, NL BURKE, DS TI NATURAL-HISTORY OF HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION SO DERMATOLOGIC CLINICS LA English DT Article RP MICHAEL, NL (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV RETROVIROL,WASHINGTON,DC 20307, USA. OI /0000-0002-5704-8094 NR 0 TC 5 Z9 5 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0733-8635 J9 DERMATOL CLIN JI Dermatol. Clin. PD JUL PY 1991 VL 9 IS 3 BP 429 EP 441 PG 13 WC Dermatology SC Dermatology GA FU803 UT WOS:A1991FU80300006 PM 1873924 ER PT J AU BRUNDAGE, JF AF BRUNDAGE, JF TI EPIDEMIOLOGY OF HIV-INFECTION AND AIDS IN THE UNITED-STATES SO DERMATOLOGIC CLINICS LA English DT Article RP BRUNDAGE, JF (reprint author), WALTER REED ARMY MED CTR,DEPT EPIDEMIOL,DIV PREVENT MED,WASHINGTON,DC 20307, USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0733-8635 J9 DERMATOL CLIN JI Dermatol. Clin. PD JUL PY 1991 VL 9 IS 3 BP 443 EP 452 PG 10 WC Dermatology SC Dermatology GA FU803 UT WOS:A1991FU80300007 PM 1873925 ER PT J AU ROBERTS, CR AF ROBERTS, CR TI LABORATORY DIAGNOSIS OF RETROVIRAL INFECTIONS SO DERMATOLOGIC CLINICS LA English DT Article RP ROBERTS, CR (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT RETROVIROL,WASHINGTON,DC 20307, USA. NR 0 TC 5 Z9 5 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0733-8635 J9 DERMATOL CLIN JI Dermatol. Clin. PD JUL PY 1991 VL 9 IS 3 BP 453 EP 464 PG 12 WC Dermatology SC Dermatology GA FU803 UT WOS:A1991FU80300008 PM 1678688 ER PT J AU HICKS, CB AF HICKS, CB TI SYPHILIS AND HIV-INFECTION SO DERMATOLOGIC CLINICS LA English DT Article RP HICKS, CB (reprint author), WALTER REED ARMY MED CTR,INFECT DIS SERV,WASHINGTON,DC 20307, USA. NR 0 TC 14 Z9 15 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0733-8635 J9 DERMATOL CLIN JI Dermatol. Clin. PD JUL PY 1991 VL 9 IS 3 BP 493 EP 501 PG 9 WC Dermatology SC Dermatology GA FU803 UT WOS:A1991FU80300010 PM 1873927 ER PT J AU JAMES, W AF JAMES, W TI AIDS - A 10-YEAR PERSPECTIVE - PREFACE SO DERMATOLOGIC CLINICS LA English DT Editorial Material RP JAMES, W (reprint author), WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0733-8635 J9 DERMATOL CLIN JI Dermatol. Clin. PD JUL PY 1991 VL 9 IS 3 BP R13 EP R14 PG 2 WC Dermatology SC Dermatology GA FU803 UT WOS:A1991FU80300001 ER PT J AU PINTER, GG ATKINS, JL AF PINTER, GG ATKINS, JL TI ROLE OF POSTGLOMERULAR MICROVESSELS IN PATHOPHYSIOLOGY OF DIABETIC NEPHROPATHY - ASSESSMENT AND HYPOTHESIS SO DIABETES LA English DT Article ID PERITUBULAR CAPILLARIES; FILTRATION SURFACE; RENAL CORTEX; MELLITUS; PERMEABILITY; KIDNEY; RAT AB Although glomerular damage plays a well-established and important role in the pathomechanism of diabetic nephropathy, it alone does not fully explain the progression of renal complications in long-term diabetes mellitus. We discuss experimental evidence showing involvement of the postglomerular microvessels (peritubular capillaries and venules) in diabetic microangiopathy. This involvement is manifest in increased permeability of these vessels to plasma proteins and in highly augmented lymphatic drainage of the extravasated proteins from the renal interstitium. We suggest that in the advanced phase of diabetic nephropathy, proteinuria (corresponding to excess leakage of proteins through the glomerular capillary wall) indicates the probability that postglomerular microvessels have also allowed leakage of plasma proteins. As long as lymphatic drainage is capable of removing the increased quantity of extravasated plasma proteins from the interstitum, renal function should not be deleteriously affected. However, if the excess amount of extravasated proteins exceeds the capacity of lymphatic drainage, increases in interstitial volume and pressure are unavoidable with detrimental consequences for glomerular filtration and tubular reabsorption. Under these conditions, a potential positive-feedback loop can be visualized that involves increased extravasation of plasma proteins leading to increased interstitial pressure that through dilation of the afferent and efferent arterioles results in a further increase in protein extravasation. These conditions combined with glomerular damage should lead to the eventual collapse of renal function. C1 UNIV LONDON KINGS COLL,PHYSIOL GRP,DIV BIOMED SCI,LONDON WC2R 2LS,ENGLAND. WALTER REED ARMY MED CTR,DEPT NEPHROL,WASHINGTON,DC 20307. RP PINTER, GG (reprint author), UNIV MARYLAND,SCH MED,DEPT PHYSIOL,660 W REDWOOD ST,BALTIMORE,MD 21201, USA. RI Atkins, James/B-3577-2011 NR 24 TC 14 Z9 15 U1 0 U2 0 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1660 DUKE ST, ALEXANDRIA, VA 22314 SN 0012-1797 J9 DIABETES JI Diabetes PD JUL PY 1991 VL 40 IS 7 BP 791 EP 795 DI 10.2337/diabetes.40.7.791 PG 5 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA FU962 UT WOS:A1991FU96200001 PM 2060715 ER PT J AU GOLD, K BRODMAN, BW AF GOLD, K BRODMAN, BW TI STUDIES ON THE DISTRIBUTION OF A NATURALLY-OCCURRING NITROALIPHATIC ACID IN CROWNVETCH (CORONILLA-VARIA, FABACEAE) SO ECONOMIC BOTANY LA English DT Article DE CORONILLA-VARIA; CROWNVETCH; 3-NITROPROPIONIC ACID ID ISOSORBIDE DINITRATE; BIOCONVERSION AB The biosynthesis of nitro compounds and their esterification to glucose moieties are rare phenomena in the plant kingdom. Crownvetch (C. varia, Fabaceae) has not only these special biosynthetic capabilities, but also a nitro compound degrading system of interest to the energetic materials utilizing sectors. In this study we extend the observations on 3-nitropropionic acid content in crownvetch to pods and seedling tissues. The seedlings are recommended as preferred sources of enzymes capable of synthesis, and the mature plant tissues for degrading enzymes. RP GOLD, K (reprint author), USA,CTR ARMAMENT RES DEV & ENGN,PICATINNY ARSENAL,NJ 07806, USA. NR 20 TC 2 Z9 2 U1 1 U2 2 PU NEW YORK BOTANICAL GARDEN PI BRONX PA PUBLICATIONS DEPT, BRONX, NY 10458 SN 0013-0001 J9 ECON BOT JI Econ. Bot. PD JUL-SEP PY 1991 VL 45 IS 3 BP 334 EP 338 DI 10.1007/BF02887073 PG 5 WC Plant Sciences SC Plant Sciences GA GL533 UT WOS:A1991GL53300004 ER PT J AU SMALLRIDGE, RC GIST, ID AMBROZ, C AF SMALLRIDGE, RC GIST, ID AMBROZ, C TI 8-DIETHYLAMINO-OCTYL-3,4,5-TRIMETHOXYBENZOATE, A CALCIUM STORE BLOCKER, INCREASES CALCIUM INFLUX, INHIBITS ALPHA-1 ADRENERGIC-RECEPTOR CALCIUM MOBILIZATION, AND ALTERS IODIDE TRANSPORT IN FRTL-5 RAT-THYROID CELLS SO ENDOCRINOLOGY LA English DT Article ID CYTOSOLIC FREE CALCIUM; TMB-8 8-(NN-DIETHYLAMINO)OCTYL-3,4,5-TRIMETHOXYBENZOATE; ADENOSINE-TRIPHOSPHATE; EPITHELIAL-CELLS; CA-2+; THYROTROPIN; STIMULATION; ANTAGONIST; EFFLUX; MECHANISM AB 8-Diethylamino-octyl-3,4,5-trimethoxybenzoate (TMB-8) is known to inhibit mobilization of calcium from intracellular store but, more recently, other cellular effects have been described. In the present study, the effects of TMB-8 on cytosolic free calcium [Ca2+]i levels in FRTL-5 rat thyroid cells were determined using the fluorescent dye, Indo-1. TMB-8 increased [Ca2+]i in a dose-dependent manner, with a maximum rise from 120 +/- 7 nM to 229 +/- 16 nM (90 +/- 5% increase) at 5 x 10(-4) M. This effect was considerably reduced in Ca2+ free buffer, demonstrating a dependency upon extracellular calcium influx but not upon membrane potential and which did not involve the Na+/Ca2+ exchanger. In Ca2+ free buffer TMB-8, at a dose which did not affect [Ca2+]i, completely prevented norepinephrine (10(-5)M) from mobilizing intracellular Ca2+. To determine whether TMB-8 affected differentiated functions, iodide uptake and efflux studies were performed with I-125. TMB-8 (10(-4) M) inhibited iodide uptake by approximately 40% without affecting efflux. At 10(-3) M TMB-8, efflux was also enhanced. These studies demonstrate that TMB-8 has at least two effects on [Ca2+]i, promoting calcium influx and preventing alpha-1 adrenergic mobilization from intracellular stores. TMB-8 also has multiple effects on I-125 transport, both inhibiting influx and increasing efflux. The results emphasize the importance of characterizing the behavior of this compound in any cell system before using it as a biological probe. RP SMALLRIDGE, RC (reprint author), WALTER REED ARMY MED CTR,DIV MED,DEPT CLIN PHYSIOL,WASHINGTON,DC 20307, USA. NR 31 TC 19 Z9 19 U1 0 U2 0 PU ENDOCRINE SOC PI BETHESDA PA 4350 EAST WEST HIGHWAY SUITE 500, BETHESDA, MD 20814-4110 SN 0013-7227 J9 ENDOCRINOLOGY JI Endocrinology PD JUL PY 1991 VL 129 IS 1 BP 542 EP 549 PG 8 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA FT966 UT WOS:A1991FT96600071 PM 1647311 ER PT J AU LARUSSA, VF PUTNAK, R KNIGHT, RD AF LARUSSA, VF PUTNAK, R KNIGHT, RD TI DENGUE VIRUS-INFECTION OF STROMAL CELLS IN DEXTER CULTURES OF HUMAN MARROW SO EXPERIMENTAL HEMATOLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 2 Z9 2 U1 0 U2 0 PU CARDEN JENNINGS PUBL CO LTD PI CHARLOTTESVILLE PA BLAKE CTR, STE 200, 1224 W MAIN ST, CHARLOTTESVILLE, VA 22903 SN 0301-472X J9 EXP HEMATOL JI Exp. Hematol. PD JUL PY 1991 VL 19 IS 6 BP 479 EP 479 PG 1 WC Hematology; Medicine, Research & Experimental SC Hematology; Research & Experimental Medicine GA FQ310 UT WOS:A1991FQ31000084 ER PT J AU PETERS, CJ AF PETERS, CJ TI CITATIONS AND AREAS OF RESEARCH SO FASEB JOURNAL LA English DT Letter RP PETERS, CJ (reprint author), USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FREDERICK,MD 21701, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD JUL PY 1991 VL 5 IS 10 BP 2488 EP 2488 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FW087 UT WOS:A1991FW08700026 ER PT J AU PEROVICH, DK GOVONI, JW AF PEROVICH, DK GOVONI, JW TI ABSORPTION-COEFFICIENTS OF ICE FROM 250 TO 400 NM SO GEOPHYSICAL RESEARCH LETTERS LA English DT Article ID SEA ICE; OPTICAL-PROPERTIES; ULTRAVIOLET-RADIATION; TRANSMISSION AB Absorption coefficients for pure bubble-free ice are a critical element in theoretical efforts to determine levels of ultraviolet radiation reaching marine biota in and under a sea ice cover. A 3-m block of ice was used to measure these coefficients from 250 to 400 nm. Absorption coefficients were found to increase from 0.092 m-1 at 400nm to 0.665 m-1 at 250nm. Values in the ultraviolet were shown to be comparable to visible results from 580 to 720 nm. This suggests that existing data on the interaction of visible light with snow and sea ice can be used as a first-order estimate of ultraviolet optical properties. RP PEROVICH, DK (reprint author), USA,COLD REG RES & ENGN LAB,WASHINGTON,DC 20310, USA. NR 14 TC 73 Z9 75 U1 0 U2 8 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0094-8276 J9 GEOPHYS RES LETT JI Geophys. Res. Lett. PD JUL PY 1991 VL 18 IS 7 BP 1233 EP 1235 DI 10.1029/91GL01642 PG 3 WC Geosciences, Multidisciplinary SC Geology GA FW155 UT WOS:A1991FW15500016 ER PT J AU JARDI, R BUTI, M RODRIGUEZFRIAS, F GARCIALAFUENTE, A SJOGREN, MH ESTEBAN, R GUARDIA, J AF JARDI, R BUTI, M RODRIGUEZFRIAS, F GARCIALAFUENTE, A SJOGREN, MH ESTEBAN, R GUARDIA, J TI CLINICAL-SIGNIFICANCE OF 2 FORMS OF IGM ANTIBODY TO HEPATITIS DELTA VIRUS SO HEPATOLOGY LA English DT Article ID B CORE ANTIGEN; IMMUNOGLOBULIN-M ANTIBODY; INFECTION; SERUM AB Separation of 7-8 S and 19 S forms of serum IgM antibodies to the hepatitis delta virus by rate-zonal centrifugation was carried out on serum from 24 patients with hepatitis delta virus infection: 4 patients with acute, self-limited hepatitis; 5 patients with hepatitis delta virus superinfection progressing to chronicity; and 15 patients with chronic hepatitis delta virus. The high molecular weight IgM form (19 S) was predominantly detected in acute hepatitis delta virus cases, whereas the low molecular weight (7 S) form was found in chronic hepatitis delta virus cases. The serological profile of these two forms of IgM antibody to hepatitis delta virus was investigated in serial samples from five patients with acute hepatitis delta virus superinfection that evolved to chronic hepatitis delta virus. We found that, in the acute stage of the disease, the 19 S form was predominant, whereas 6 mo later a predominance of 7-8 S IgM was observed. These results suggest that IgM antibody to hepatitis delta virus antibody forms are different in acute and chronic hepatitis delta virus infection and that their detection only helps in differentiating an acute infection from a chronic infection but not a hepatitis delta virus - hepatitis B virus-HBV coinfection from hepatitis delta virus superinfection in the acute stage of the disease. C1 UNIV AUTONOMA BARCELONA,HOSP GEN VALLE HEBRON,DEPT INTERNAL MED,SERV HEPATOL,LIVER UNIT,E-08035 BARCELONA,SPAIN. UNIV AUTONOMA BARCELONA,HOSP GEN VALLE HEBRON,DEPT BIOCHEM,E-08035 BARCELONA,SPAIN. WALTER REED ARMY MED CTR,DEPT VIRUS DIS,WASHINGTON,DC 20307. NR 11 TC 8 Z9 8 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD JUL PY 1991 VL 14 IS 1 BP 25 EP 28 DI 10.1002/hep.1840140105 PG 4 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA FW002 UT WOS:A1991FW00200004 PM 2066073 ER PT J AU XU, SJ MIN, JH PENG, ST SCHWERING, FK AF XU, SJ MIN, JH PENG, ST SCHWERING, FK TI A MILLIMETER-WAVE OMNIDIRECTIONAL CIRCULAR DIELECTRIC ROD GRATING ANTENNA SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Article AB A millimeter-wave omnidirectional circular dielectric rod grating antenna is investigated theoretically and experimentally. As an eigenvalue problem, the antenna is analyzed with the rigorous mode matching method. The radiation characteristics of the antenna are calculated and measured in the Ka-band frequency range. A comparison between the experimental results and the theoretical predictions is made and very good agreement is found. The practicality of the omnidirectional antenna and the effectiveness of the theory are thus justified. C1 NEW YORK INST TECHNOL,OLD WESTBURY,NY 11568. USA,COMMUN ELECTR COMMAND,FT MONMOUTH,NJ 07703. RP XU, SJ (reprint author), UNIV SCI & TECHNOL CHINA,DEPT RADIO & ELECTR,HEFEI,PEOPLES R CHINA. NR 8 TC 30 Z9 33 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-926X J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD JUL PY 1991 VL 39 IS 7 BP 883 EP 891 DI 10.1109/8.86905 PG 9 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA FZ277 UT WOS:A1991FZ27700002 ER PT J AU OBERHELMAN, RA KOPECKO, DJ SALAZARLINDO, E GOTUZZO, E BUYSSE, JM VENKATESAN, MM YI, A FERNANDEZPRADA, C GUZMAN, M LEONBARUA, R SACK, RB AF OBERHELMAN, RA KOPECKO, DJ SALAZARLINDO, E GOTUZZO, E BUYSSE, JM VENKATESAN, MM YI, A FERNANDEZPRADA, C GUZMAN, M LEONBARUA, R SACK, RB TI PROSPECTIVE-STUDY OF SYSTEMIC AND MUCOSAL IMMUNE-RESPONSES IN DYSENTERIC PATIENTS TO SPECIFIC SHIGELLA INVASION PLASMID ANTIGENS AND LIPOPOLYSACCHARIDES SO INFECTION AND IMMUNITY LA English DT Article ID ANTIBODY-RESPONSES; ESCHERICHIA-COLI; RHESUS-MONKEYS; FLEXNERI; DIARRHEA; SERUM; INFECTION; GENES; ENTEROPATHOGENS; POPULATION AB Shigellosis is a major cause of infant morbidity and mortality in developing countries. To find immunological correlates of specific protection against shigellosis, we examined chronological samples of sera, stool extracts, duodenal aspirates, and saliva samples from 39 adults and 22 children with shigellosis from Peru for the presence of specific antibody to invasion plasmid antigens (Ipa) common to all virulent Shigella strains, by using both a whole-organism enzyme-linked immunosorbent assay (ELISA) and a Western blot (immunoblot) assay. Antibody responses to lipopolysaccharide (LPS) from Shigella serotypes both homologous and heterologous to the infecting strain were also determined by ELISA. ELISAs showed that the highest serum immunoglobulin G (IgG) antibody titers to Shigella whole organisms both with and without surface Ipa were found in adults and malnourished children, the two groups with the shortest and longest durations of disease, respectively. Mucosal IgA antibody titers to Shigella strains decreased over time to a much greater extent than serum IgG titers, and IgA to Ipa in mucosal secretions was found in adults and well-nourished children but not in malnourished children. The presence of mucosal antibody to Ipa may limit the spread and severity of the infection, as indicated by the prolonged illness observed in malnourished children who have no significant mucosal antibody to Shigella Ipa. Serum antibody titers to the Ipa antigens were high relative to anti-Shigella LPS antibody titers, especially in pediatric patients. In contrast to the anti-Ipa responses observed, no differences in antibody responses to LPS in children compared by nutritional status were found. High levels of serum and mucosal cross-reacting antibody to heterologous serotype LPS were found between Shigella flexneri serotypes 1a and 2a. Different patterns of immune response to Ipa proteins and LPS that may aid in the definition of Shigella antigens important in host protection were observed in adults, well-nourished children, and malnourished children. C1 JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT INT HLTH,DIV GEOG MED,BALTIMORE,MD 21205. WALTER REED ARMY MED CTR,DEPT BACTERIAL IMMUNOL,WASHINGTON,DC 20307. UNIV PERUANA CAYETANO HEREDIA,LIMA 100,PERU. FU NIAID NIH HHS [5 PO1 AI20130] NR 29 TC 71 Z9 71 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD JUL PY 1991 VL 59 IS 7 BP 2341 EP 2350 PG 10 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA FT922 UT WOS:A1991FT92200018 PM 2050402 ER PT J AU BROWN, GG CLEMENCE, RD TEUFERT, WR WOOD, RK AF BROWN, GG CLEMENCE, RD TEUFERT, WR WOOD, RK TI AN OPTIMIZATION MODEL FOR MODERNIZING THE ARMY HELICOPTER FLEET SO INTERFACES LA English DT Article DE MILITARY; COST EFFECTIVENESS PROGRAMMING; INTEGER APPLICATIONS FINANCE; CAPITAL BUDGETING AB The helicopter has grown in military stature for more than 40 years: its ascendancy has reformed the US Army. Unfortunately, the current army helicopter fleet consists predominantly of Vietnam-era aircraft approaching the end of their useful lives. We have captured complex procurement and modernization tasks in an optimization-based decision support system, christened PHOENIX, which recognizes yearly operating, maintenance, retirement, service-life extension, and new procurement costs while enforcing constraints on fleet age, technology mix, composition, and budgets over a multi-year planning horizon. The army has applied PHOENIX to helicopters with such success that it has already been adapted to tactical wheeled vehicles and is under consideration for further applications. C1 USA,CONCEPTS ANAL AGCY,BETHESDA,MD 20814. RP BROWN, GG (reprint author), USN,POSTGRAD SCH,DEPT OPERAT RES,MONTEREY,CA 93943, USA. NR 10 TC 11 Z9 11 U1 0 U2 2 PU INST OPERATIONS RESEARCH MANAGEMENT SCIENCES PI LINTHICUM HTS PA 901 ELKRIDGE LANDING RD, STE 400, LINTHICUM HTS, MD 21090-2909 SN 0092-2102 J9 INTERFACES JI Interfaces PD JUL-AUG PY 1991 VL 21 IS 4 BP 39 EP 52 DI 10.1287/inte.21.4.39 PG 14 WC Management; Operations Research & Management Science SC Business & Economics; Operations Research & Management Science GA GC627 UT WOS:A1991GC62700005 ER PT J AU YOUNGREN, MA AF YOUNGREN, MA TI MODELING RELOCATABLE NUCLEAR TARGETS SO INTERFACES LA English DT Article DE MILITARY; TARGETING PROBABILITY; RENEWAL PROCESSES AB The US Army Concepts Analysis Agency (CAA) is responsible for modeling the employment of tactical nuclear weapons at the theater level. The currently available simulation that models the exchange of tactical nuclear weapons takes a lot of time to set up and run. CAA has used a simple probability model based on alternating renewal processes to make a quick estimate of the probability that a relocatable combat unit can be acquired and engaged by nuclear weapons, without a loss in accuracy compared to the detailed simulation. The model may be applied to either tactical or strategic relocatable targets. RP YOUNGREN, MA (reprint author), USA,CONCEPTS ANAL AGCY,BETHESDA,MD 20814, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU INST OPERATIONS RESEARCH MANAGEMENT SCIENCES PI LINTHICUM HTS PA 901 ELKRIDGE LANDING RD, STE 400, LINTHICUM HTS, MD 21090-2909 SN 0092-2102 J9 INTERFACES JI Interfaces PD JUL-AUG PY 1991 VL 21 IS 4 BP 132 EP 140 DI 10.1287/inte.21.4.132 PG 9 WC Management; Operations Research & Management Science SC Business & Economics; Operations Research & Management Science GA GC627 UT WOS:A1991GC62700012 ER PT J AU THACH, AB MARAK, GE MCLEAN, IW GREEN, WR AF THACH, AB MARAK, GE MCLEAN, IW GREEN, WR TI PHACOANAPHYLACTIC ENDOPHTHALMITIS - A CLINICOPATHOLOGICAL REVIEW SO INTERNATIONAL OPHTHALMOLOGY LA English DT Review DE ARTHUS REACTION; IMMUNE COMPLEX-MEDIATED REACTION; PHACOANAPHYLACTIC ENDOPHTHALMITIS; LENS-INDUCED UVEITIS; UVEITIS ID EXTRACAPSULAR CATARACT-EXTRACTION; INDUCED GRANULOMATOUS ENDOPHTHALMITIS; INTRAOCULAR-LENS IMPLANTATION; PROPIONIBACTERIUM-ACNES; SYMPATHETIC OPHTHALMIA; PROTEIN AB Lens-induced uveitis or phacoanaphylactic endophthalmitis (PE) is a chronic endophthalmitis with a zonal granulomatous inflammation surrounding a reptured lens. One hundred forty four cases of PE were retrospectively evaluated clinically and histopathologically. The disease was not well recognized clinically as only six of the cases were given the clinical diagnosis of PE. Most cases (80%) occurred after trauma, surgical or non-surgical. The time after injury varied from two days to fifty nine years. Of those individuals less than 55 years of age who had no history of trauma, 29% were noted by clinical history to have microphthalmia. Although classically the inflammation of PE has been described as being confined to the anterior aspect of the eye, the choroid was involved with an inflammatory reaction in 76% of the cases. C1 GEORGETOWN UNIV,2059 HUNTINGTON AVE P14,ALEXANDRIA,VA 22303. ARMED FORCES INST PATHOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. JOHNS HOPKINS UNIV HOSP,EYE PATHOL LAB,BALTIMORE,MD 21205. NR 51 TC 14 Z9 14 U1 0 U2 1 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0165-5701 J9 INT OPHTHALMOL JI Int. Ophthalmol. PD JUL PY 1991 VL 15 IS 4 BP 271 EP 279 PG 9 WC Ophthalmology SC Ophthalmology GA FW703 UT WOS:A1991FW70300010 PM 1917323 ER PT J AU BENEDIKT, RA JELINEK, JS SCHAEFER, PS EDWARDS, F GHAED, V AF BENEDIKT, RA JELINEK, JS SCHAEFER, PS EDWARDS, F GHAED, V TI RIGHT-SIDE AORTIC-ARCH WITH ANEURYSM OF ABERRANT LEFT SUBCLAVIAN ARTERY - MR IMAGING APPEARANCE SO JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING LA English DT Note DE AORTA, ABNORMALITIES; ANEURYSM, MR STUDIES; ANEURYSM, SUBCLAVIAN; ARTERIES, MR STUDIES AB Reports of aneurysms of the subclavian artery in both normal and anomalous aortic arches have been rare. The authors describe a patient with a right-side aortic arch and an aneurysm of the aberrant left subclavian artery. which, to the authors' knowledge, is a previously unreported association. At presentation, the aneurysm appeared as a calcified left superior mediastinal mass. Magnetic resonance imaging enabled preoperative diagnosis and guided surgical planning. RP BENEDIKT, RA (reprint author), WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307, USA. NR 0 TC 5 Z9 5 U1 0 U2 0 PU SOC MAGNETIC RESONANCE IMAGING PI EASTON PA 1991 NORTHAMPTON ST, EASTON, PA 18042-3189 SN 1053-1807 J9 JMRI-J MAGN RESON IM JI JMRI-J. Magn. Reson. Imaging PD JUL-AUG PY 1991 VL 1 IS 4 BP 485 EP 486 DI 10.1002/jmri.1880010415 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA HA766 UT WOS:A1991HA76600014 PM 1790371 ER PT J AU CROWSON, A CHEN, ES AF CROWSON, A CHEN, ES TI THE TMS SYMPOSIUM ON RECENT ADVANCES IN TUNGSTEN AND TUNGSTEN ALLOYS SO JOM-JOURNAL OF THE MINERALS METALS & MATERIALS SOCIETY LA English DT Review C1 USA,OFF RES,MECH BEHAV MAT PROGRAM,RES TRIANGLE PK,NC 27709. RP CROWSON, A (reprint author), USA,OFF RES,DIV MAT SCI,RES TRIANGLE PK,NC 27709, USA. NR 0 TC 4 Z9 6 U1 0 U2 2 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 420 COMMONWEALTH DR, WARRENDALE, PA 15086 SN 1047-4838 J9 JOM-J MIN MET MAT S JI JOM-J. Miner. Met. Mater. Soc. PD JUL PY 1991 VL 43 IS 7 BP 27 EP 29 PG 3 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing SC Materials Science; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing GA FZ553 UT WOS:A1991FZ55300006 ER PT J AU CHYLEK, P PINNICK, RG SRIVASTAVA, V AF CHYLEK, P PINNICK, RG SRIVASTAVA, V TI EFFECT OF TOPOLOGY OF WATER-ICE MIXTURE ON RADAR BACKSCATTERING BY HAILSTONES SO JOURNAL OF APPLIED METEOROLOGY LA English DT Article ID OPTICAL-PROPERTIES; PARTICLES AB The radar backscattering cross sections of spongy hailstones are considerably influenced by the topological structure of the water-ice mixture. Observational evidence suggests that such an inhomogeneous composite medium can consist of regions of different topologies. We investigate three different kinds of topologies and derive a general mixed topology mixing rule (MTMR). The mixed topology rule is used to calculate the effective dielectric constant of spongy ice as a function of its liquid-water content. This leads to predictions of backscatter cross sections that are in good agreement with measurement. C1 DALHOUSIE UNIV,DEPT PHYS & OCEANOG,HALIFAX B3H 4H2,NS,CANADA. ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM. UNIV SPACE RES ASSOC,HUNTSVILLE,AL. NR 24 TC 5 Z9 5 U1 0 U2 0 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 SN 0894-8763 J9 J APPL METEOROL JI J. Appl. Meteorol. PD JUL PY 1991 VL 30 IS 7 BP 954 EP 959 DI 10.1175/1520-0450-30.7.954 PG 6 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA FX373 UT WOS:A1991FX37300003 ER PT J AU KIM, KW STROSCIO, MA BHATT, A MICKEVICIUS, R MITIN, VV AF KIM, KW STROSCIO, MA BHATT, A MICKEVICIUS, R MITIN, VV TI ELECTRON-OPTICAL-PHONON SCATTERING RATES IN A RECTANGULAR SEMICONDUCTOR QUANTUM WIRE SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID CONFINED LO; MODES; POLARIZABILITY; SUPERLATTICES; GAS AB One-dimensional electron-optical-phonon interaction Hamiltonians in a rectangular quantum wire consisting of diatomic polar semiconductors are derived under the macroscopic dielectric continuum model. The scattering rates calculated in a GaAs square quantum wire show that when the quantum wire is free-standing in vacuum, the interaction by the surface-optical phonon modes is very strong and may dominate over other scattering processes, especially with dimensions of about 100 angstrom or less. When the wire is embeded in a polar semiconductor (AlAs to be specific), the scattering rates by the confined longitudinal-optical modes as the wire dimension shrinks. A considerable decrease in the total scattering rate for optical phonons as a result of simple reduction in dimensionality is not observed in this study. C1 USA, RES OFF, RES TRIANGLE PK, NC 27709 USA. WAYNE STATE UNIV, DEPT ELECT & COMP ENGN, DETROIT, MI 48202 USA. RP KIM, KW (reprint author), N CAROLINA STATE UNIV, DEPT ELECT & COMP ENGN, RALEIGH, NC 27695 USA. NR 19 TC 109 Z9 110 U1 0 U2 1 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD JUL 1 PY 1991 VL 70 IS 1 BP 319 EP 325 DI 10.1063/1.350275 PG 7 WC Physics, Applied SC Physics GA FV069 UT WOS:A1991FV06900050 ER PT J AU MARCY, DL MABY, EW NEWMAN, PG KHANNA, R AF MARCY, DL MABY, EW NEWMAN, PG KHANNA, R TI SPECIFIC RESISTIVITY OF DELTA-DOPED CONTACTS IN N-GAAS SO JOURNAL OF APPLIED PHYSICS LA English DT Note ID OHMIC CONTACTS; RESISTANCE AB Specific contact resistivities of nonalloyed Si delta-doped contacts to n-GaAs have been measured using six-terminal Kelvin test structures. The results indicate that multiple near-surface delta layers are needed to obtain ohmic contacts with resistivities of about 10(-5) OMEGA cm2. Lower resistivity values may be possible if the Si donor incorporation limit can be increased above 3 x 10(19) cm-3 through improved growth conditions. Delta-layer effectiveness is degraded by process conditions that feature a Si3N4 overlayer. C1 RENSSELAER POLYTECH INST,CTR INTEGRATED ELECTR,TROY,NY 12180. USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. PENN STATE UNIV,CTR ELECTR MAT & PROCESS,STATE COLL,PA 16801. RP MARCY, DL (reprint author), RENSSELAER POLYTECH INST,DEPT ELECT COMP & SYST ENGN,TROY,NY 12180, USA. NR 8 TC 6 Z9 6 U1 1 U2 5 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JUL 1 PY 1991 VL 70 IS 1 BP 514 EP 516 DI 10.1063/1.350264 PG 3 WC Physics, Applied SC Physics GA FV069 UT WOS:A1991FV06900085 ER PT J AU HOYT, RW JONES, TE STEIN, TP MCANINCH, GW LIEBERMAN, HR ASKEW, EW CYMERMAN, A AF HOYT, RW JONES, TE STEIN, TP MCANINCH, GW LIEBERMAN, HR ASKEW, EW CYMERMAN, A TI DOUBLY LABELED WATER MEASUREMENT OF HUMAN ENERGY-EXPENDITURE DURING STRENUOUS EXERCISE SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE ACTIVITY MONITORING; ANTHROPOMETRY; BODY COMPOSITION; FOOD INTAKE-ENERGY BALANCE; FREE LIVING ID SOLDIERS; BALANCE; MAMMALS; O-18 AB The energy expenditures (EE) of 23 adult male Marines were measured during a strenuous 11-day cold-weather field exercise at 2,200- to 2,550-m elevation by both doubly labeled water (H2O)-H-2-O-18, DLW) and intake balance methods. The DLW EE calculations were corrected for changes in baseline isotopic abundances in a control group that did not receive (H2O)-H-2-O-18. Intake balance EE was estimated from the change in body energy stores and food intake. Body energy-store changes were calculated from anthropometric [-1,574 +/- 144 (SE) kcal/day] and isotope dilution (-1,872 +/- 293 kcal/day) measurements made before and after the field exercise. The subjects kept daily log-book records of ration consumption (3,132 +/- 165 kcal/day). Mean DLW EE (4,919 +/- 190 kcal/day) did not differ significantly from intake balance EE estimated from food intake and either anthropometric (4,705 +/- 181 kcal/day) or isotope dilution (5,004 +/- 240 kcal/day) estimates of the change in body energy stores. The DLW method can be used with at least the same degree of confidence as the intake balance method to measure the EE of active free-living humans. C1 UNIV MED & DENT NEW JERSEY,SCH OSTEOPATH MED,DEPT SURG,CAMDEN,NJ 08103. MARINE CORPS MT WARFARE TRAINING CTR,BRIDGEPORT,CA 93517. RP HOYT, RW (reprint author), USA,DIV ALTITUDE PHYSIOL & MED,ENVIRONM MED RES INST,NATICK,MA 01760, USA. NR 30 TC 53 Z9 55 U1 0 U2 2 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD JUL PY 1991 VL 71 IS 1 BP 16 EP 22 PG 7 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA FV262 UT WOS:A1991FV26200004 PM 1917738 ER PT J AU NETHERLAND, MD GREEN, WR GETSINGER, KD AF NETHERLAND, MD GREEN, WR GETSINGER, KD TI ENDOTHALL CONCENTRATION AND EXPOSURE TIME RELATIONSHIPS FOR THE CONTROL OF EURASIAN WATERMILFOIL AND HYDRILLA SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE HERBICIDE; CHEMICAL CONTROL; ENDOTHALL; BIOMASS; EXPOSURE TIME; EURASIAN WATERMILFOIL; HYDRILLA AB Herbicide concentration and exposure time relationships were determined for endothall (the dipotassium salt of 7-oxabicyclo [2,2,1] heptane-2,3- dicarboxylic acid) and control of Eurasian watermilfoil (Myriopyllum spicatum L.) and dioecious hydrilla (Hydrilla verticillata L. F. Royle) under controlled-environment conditions. Sixteen endothall concentration and exposure time combinations were tested for Eurasian watermilfoil: concentrations ranged from 0.5 to 5.0 mg acid equivalent (ae)/1; exposure times ranged from 2 to 72 hr. Twenty-seven endothall concentration and exposure time combinations were tested for hydrilla: concentrations ranged from 1.0 to 5.0 mg ae/1; exposure times ranged from 6 to 72 hr. Plant control was based on shoot and root biomass harvested at the end of the experiments. Weekly visual injury ratings were used to characterize efficacy during the course of the experiments. Plant control increased (biomass decreased), as either concentration or exposure time increased. A threshold level was reached in which a concentration/exposure time combination provided satisfactory control. Severe Eurasian watermilfoil injury (> 85% biomass reduction) occurred when exposed to 0.5 mg ae/1 for 48 hr, 1.0 mg ae/1 for 36 hr, 3.0 mg ae/1 for 18 hr, and 5.0 mg ae/1 for 12 hr. Severe hydrilla injury (> 85% biomass reduction) occurred when exposed to 2.0 mg ae/1 for 48 hr, and 3.0, 4.0 and 5.0 mg ae/1 for 24 hr. The 1.0 mg ae/1 treatment failed to produce severe hydrilla injury at the maximum exposure time tested of 72 hr. Increased control of Eurasian watermilfoil and hydrilla is likely for treatments in systems where plants remain in contact with endothall concentrations and exposure times greater than the developed threshold levels. C1 US GEOL SURVEY,LITTLE ROCK,AR 72205. RP NETHERLAND, MD (reprint author), USA,ENGN WATERWAYS EXPT STN,ENVIRONM LAB,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 12 TC 39 Z9 39 U1 1 U2 4 PU AQUATIC PLANT MANAGEMENT SOC, INC PI CLERMONT PA PO BOX 121086, CLERMONT, FL 34712-1086 SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 1991 VL 29 BP 61 EP 67 PG 7 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA GF535 UT WOS:A1991GF53500001 ER PT J AU TURNER, EG NETHERLAND, MD GETSINGER, KD AF TURNER, EG NETHERLAND, MD GETSINGER, KD TI SUBMERSED PLANTS AND ALGAE AS FACTORS IN THE LOSS OF RHODAMINE WT DYE SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Note RP TURNER, EG (reprint author), ASCI CORP,ENVIRONM LAB,USA ENGINEER WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 9 TC 6 Z9 6 U1 1 U2 3 PU AQUATIC PLANT MANAGEMENT SOC, INC PI CLERMONT PA PO BOX 121086, CLERMONT, FL 34712-1086 SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 1991 VL 29 BP 113 EP 115 PG 3 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA GF535 UT WOS:A1991GF53500011 ER PT J AU ROTH, RJ ACTON, N AF ROTH, RJ ACTON, N TI A FACILE SEMISYNTHESIS OF THE ANTIMALARIAL DRUG QINGHAOSU SO JOURNAL OF CHEMICAL EDUCATION LA English DT Article ID ARTEMISINIC ACID; CONVERSION C1 WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. RP ROTH, RJ (reprint author), GEORGE MASON UNIV,FAIRFAX,VA 22030, USA. NR 5 TC 37 Z9 37 U1 1 U2 8 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0021-9584 J9 J CHEM EDUC JI J. Chem. Educ. PD JUL PY 1991 VL 68 IS 7 BP 612 EP 613 PG 2 WC Chemistry, Multidisciplinary; Education, Scientific Disciplines SC Chemistry; Education & Educational Research GA GB720 UT WOS:A1991GB72000036 ER PT J AU WEDEGE, E CAUGANT, DA FROHOLM, LO ZOLLINGER, WD AF WEDEGE, E CAUGANT, DA FROHOLM, LO ZOLLINGER, WD TI CHARACTERIZATION OF SEROGROUP-A AND SEROGROUP-B STRAINS OF NEISSERIA-MENINGITIDIS WITH SEROTYPE-4 AND SEROTYPE-21 MONOCLONAL-ANTIBODIES AND BY MULTILOCUS ENZYME ELECTROPHORESIS SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID OUTER-MEMBRANE PROTEINS; WHOLE-CELL ELISA; EPIDEMIC; ANTIGENS AB The reactions of serogroup A strains of Neisseria meningitidis with one monoclonal antibody specific for serotype 21 and three different monoclonal antibodies specific for serotype 4 were compared with those of serogroup B strains previously assigned to serotype 4. Antibody binding was studied by enzyme-linked immunosorbent assay (ELISA), dot blotting, and immunoblotting. Characterization of the isolates by the electrophoretic mobilities of 14 metabolic enzymes showed 50 multilocus enzyme genotypes. All except two genotypes fell into three distinct clusters: I, IIa, and IIb. The enzyme genotypes of serogroup B strains were mainly in cluster I, and 88% of the serogroup A strains had genotypes in clusters IIa and IIb. Serogroup B strains generally reacted with all three serotype 4 monoclonal antibodies in ELISA and dot blotting but with only two in immunoblots. Serogroup A strains showed two different reactions in the blotting methods: either binding of the serotype 21 antibody only or binding of this and two of the three serotype 4 monoclonal antibodies. Strains of the first pattern were in clusters I and IIa, whereas all but two strains in cluster IIb were of the second pattern. In ELISA, an additional reaction of two of the serotype 4 monoclonal antibodies with serogroup A isolates was observed. The different binding of these two monoclonal antibodies in ELISA and the blotting methods appeared to result from heat inactivation of the meningococcal cells and use of detergent-containing reagents in ELISA. The results show that the serotype of serogroup A strains is distinct from serotype 4 of serogroup B strains. C1 WALTER REED ARMY MED CTR,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. RP WEDEGE, E (reprint author), NATL INST PUBL HLTH,DEPT METHODOL,N-0462 OSLO 4,NORWAY. NR 29 TC 20 Z9 20 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JUL PY 1991 VL 29 IS 7 BP 1486 EP 1492 PG 7 WC Microbiology SC Microbiology GA FT634 UT WOS:A1991FT63400040 PM 1909347 ER PT J AU KUTCHER, TJ BROWN, DC MAURER, PK GHAED, VN AF KUTCHER, TJ BROWN, DC MAURER, PK GHAED, VN TI DURAL TAIL ADJACENT TO ACOUSTIC NEUROMA - MR FEATURES SO JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY LA English DT Article DE ACOUSTIC NEUROMA; MENINGIOMA; MAGNETIC RESONANCE IMAGING; GADOLINIUM ID MENINGIOMAS; IMAGES AB There have been several reports describing the presence of a dural tail on enhanced MR as being specific for or suggestive of meningioma. It has also been stated that it is a specific diangostic sign in distinguishing meningioma from acoustic neuroma. We report a case of a dural tail in an acoustic neuroma. C1 WALTER REED ARMY MED CTR,DEPT NEUROSURG,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT RADIOL NUCL MED,BETHESDA,MD 20814. RP KUTCHER, TJ (reprint author), WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307, USA. NR 8 TC 29 Z9 29 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-8715 J9 J COMPUT ASSIST TOMO JI J. Comput. Assist. Tomogr. PD JUL-AUG PY 1991 VL 15 IS 4 BP 669 EP 670 DI 10.1097/00004728-199107000-00024 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA FW322 UT WOS:A1991FW32200024 PM 2061485 ER PT J AU GOHO, C AF GOHO, C TI INGESTION OF DENTAL MIRROR FRAGMENTS - REPORT OF CASE SO JOURNAL OF DENTISTRY FOR CHILDREN LA English DT Article AB A case is reported in which one treated pediatric patient gave his plastic, disposable dental mirror to a 2.5-year-old sibling, who while playing chewed on the mirror and the mirrored glass surface broke in the child's mouth. After thorough examination including x-rays, the patient was released with no further complications. Potentially severe injuries could have occurred, resulting in legal liabilities. RP GOHO, C (reprint author), USA,DENT CORPS,USA DENT ACTIV,PEDIAT DENT,DC 3,FT LEWIS,WA 98431, USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC DENTISTRY CHILD PI CHICAGO PA 211 E CHICAGO AVE, CHICAGO, IL 60611 SN 0022-0353 J9 J DENT CHILD JI J. Dent. Child. PD JUL-AUG PY 1991 VL 58 IS 4 BP 337 EP 339 PG 3 WC Dentistry, Oral Surgery & Medicine; Pediatrics SC Dentistry, Oral Surgery & Medicine; Pediatrics GA FY053 UT WOS:A1991FY05300014 ER PT J AU MCMULLEN, RK AF MCMULLEN, RK TI ECONOMIC RESTRUCTURING AND AFRICAN PUBLIC-ADMINISTRATION - ISSUES, ACTIONS, AND FUTURE CHOICES - BALOGUN,MJ, MUTAHABA,G SO JOURNAL OF DEVELOPING AREAS LA English DT Book Review RP MCMULLEN, RK (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WESTERN ILLINOIS UNIV PI MACOMB PA 900 WEST ADAMS ST, MACOMB, IL 61455 SN 0022-037X J9 J DEV AREAS JI J. Dev. Areas PD JUL PY 1991 VL 25 IS 4 BP 563 EP 564 PG 2 WC Area Studies; Economics; Planning & Development; Political Science SC Area Studies; Business & Economics; Public Administration; Government & Law GA GD875 UT WOS:A1991GD87500011 ER PT J AU DONLEY, DL WELLER, RN KULILD, JC JURCAK, JJ AF DONLEY, DL WELLER, RN KULILD, JC JURCAK, JJ TI INVITRO INTRACANAL TEMPERATURES PRODUCED BY LOW-TEMPERATURE AND HIGH-TEMPERATURE THERMOPLASTICIZED INJECTABLE GUTTA-PERCHA SO JOURNAL OF ENDODONTICS LA English DT Article ID ROOT-CANAL OBTURATION; SURFACE; SEALER AB An in vitro computerized temperature measurement system was developed to measure intracanal temperatures produced by different heated gutta-percha obturation techniques. The temperatures produced by low- and high-temperature thermoplasticized injectable gutta-percha systems were recorded and compared in this investigation. The mean intrachamber temperature of the Obtura syringe was 178.68-degrees-C. The mean temperature of the Ultrafil heater was 93.06-degrees-C. The mean temperature of the extruded gutta-percha was 137.81-degrees-C from the Obtura syringe and 62.88-degrees-C from the Ultrafil cannule. The intracanal temperature of the gutta-percha recorded for both systems showed that the gutta-percha cools rapidly after injection into the canal. C1 USA DENT ACTIV,ENDODONT RESIDENCY PROGRAM,FT GORDON,GA 30905. USA DENT ACTIV,FT HUACHUCA,AZ. USA DENT ACTIV,FT BENNING,GA. NR 12 TC 1 Z9 2 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD JUL PY 1991 VL 17 IS 7 BP 307 EP 309 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA FU298 UT WOS:A1991FU29800001 PM 1779213 ER PT J AU VIRE, DE AF VIRE, DE TI FAILURE OF ENDODONTICALLY TREATED TEETH - CLASSIFICATION AND EVALUATION SO JOURNAL OF ENDODONTICS LA English DT Article ID SUCCESS; RELIABILITY AB All endodontically treated teeth that were extracted over a 1-yr period in a busy group practice were evaluated for cause of failure. The 116 teeth collected were classified into major failure categories of prosthetic, periodontic, and endodontic origin. Of the teeth, 59.4% were prosthetic failures which were due primarily to crown fracture. Teeth that had been crowned had greater longevity than uncrowned teeth. Periodontal failures constituted 32% of the study. Only 8.6% of the failures were due to endodontic causes, but these failures became evident more quickly than those in the other categories. A classification of failures is presented, and the results are analyzed. C1 ADV EDUC PROGRAM GEN DENT 2YR,FT BRAGG,NC. NR 10 TC 118 Z9 126 U1 0 U2 9 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD JUL PY 1991 VL 17 IS 7 BP 338 EP 342 PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA FU298 UT WOS:A1991FU29800008 PM 1779219 ER PT J AU TAYLOR, GC AF TAYLOR, GC TI LYME-DISEASE - AN OVERVIEW OF ITS PUBLIC-HEALTH SIGNIFICANCE SO JOURNAL OF ENVIRONMENTAL HEALTH LA English DT Article AB In the past 10 years, Lyme disease (LD) has emerged as the most prevalent tickborne disease in the United States. The clinical manifestations vary considerably from case to case. Although treatable at all stages of infection, early detection is critical; treatment can be extensive and long-term. Control strategies offer hope; however, public awareness and the use of repellents are by far the most effective in the prevention of LD. RP TAYLOR, GC (reprint author), USA,PREVENT MED SERV,FT MONMOUTH,NJ 07703, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU NATL ENVIRON HEALTH ASSN PI DENVER PA 720 S COLORADO BLVD SUITE 970, SOUTH TOWER, DENVER, CO 80222 SN 0022-0892 J9 J ENVIRON HEALTH JI J. Environ. Health PD JUL-AUG PY 1991 VL 54 IS 1 BP 24 EP 27 PG 4 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA FU123 UT WOS:A1991FU12300005 ER PT J AU KUHLMAN, JJ LEVINE, B SMITH, ML HORDINSKY, JR AF KUHLMAN, JJ LEVINE, B SMITH, ML HORDINSKY, JR TI TOXICOLOGICAL FINDINGS IN FEDERAL AVIATION ADMINISTRATION GENERAL-AVIATION ACCIDENTS SO JOURNAL OF FORENSIC SCIENCES LA English DT Article DE TOXICOLOGY; AIRCRAFT; DEATH; DRUG IDENTIFICATION; AVIATION FATALITIES ID FATALLY INJURED DRIVERS; DRUG-USE AB Blood, urine, and tissue specimens were received from 377 Federal Aviation Administration (FAA) aviation fatalities during fiscal year 1989. Carbon monoxide at less than 10% saturation was found in 94% of the cases, and cyanide at less than 0.5 mg/L was found in 96% of the cases. Ethanol at greater than 10 mg/dL was found in 14.8% of the cases, but only 4.5% were determined to be due to ethanol ingestion from toxicological findings. Excluding nicotine and ethanol, 12.6% of the cases were positive for one or more drugs. Acetaminophen and salicylate were the most frequently found drugs. Cannabinoids were found in 1.3% of the cases and benzoylecgonine in 1.6%. There was minimal use of therapeutic drugs that cause central nervous system depression or stimulation. These results show no consistent pattern of drug involvement in civilian aviation fatalities. C1 ARMED FORCES INST PATHOL,DIV FORENS TOXICOL,WASHINGTON,DC 20306. USAF,WASHINGTON,DC 20330. USA,WASHINGTON,DC 20310. FAA,INST CIVIL AEROMED,DIV AEROMED RES,OKLAHOMA CITY,OK. NR 17 TC 27 Z9 27 U1 0 U2 2 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD JUL PY 1991 VL 36 IS 4 BP 1121 EP 1128 PG 8 WC Medicine, Legal SC Legal Medicine GA FY039 UT WOS:A1991FY03900022 PM 1919471 ER PT J AU TSAREV, SA EMERSON, SU BALAYAN, MS TICEHURST, J PURCELL, RH AF TSAREV, SA EMERSON, SU BALAYAN, MS TICEHURST, J PURCELL, RH TI SIMIAN HEPATITIS-A VIRUS (HAV) STRAIN AGM-27 - COMPARISON OF GENOME STRUCTURE AND GROWTH IN CELL-CULTURE WITH OTHER HAV STRAINS SO JOURNAL OF GENERAL VIROLOGY LA English DT Article ID COMPLETE NUCLEOTIDE-SEQUENCE; POLYMERASE CHAIN-REACTION; MOLECULAR-CLONING; WILD-TYPE; EXPERIMENTAL-INFECTION; GENE ORGANIZATION; ACID-SEQUENCES; DNA-POLYMERASE; RNA; IDENTIFICATION AB Fragments of cDNA representing greater than 99% of the entire genome of wild-type hepatitis A virus (HAV) strain AGM-27, isolated from an African green monkey, were obtained by the polymerase chain reaction and sequenced. Comparison with other HAV isolates revealed differences in the predicted amino acid sequence in functionally critical parts of the genome. Comparison of the biological properties of AGM-27 with those of human wild-type and cell culture-adapted HM-175 strains revealed that AGM-27 grew in cell culture significantly better than did wild-type HM-175, but not as well as cell culture-adapted HM-175. AGM-27 and cell culture-adapted HM-175 were distinguishable by their differential growth in CV-1, FRhK-4 and primary AGMK cells. C1 MOSCOW POLIOMYELITIS & VIRAL ENCEPHALITIDES INST,MOSCOW,USSR. WALTER REED ARMY MED CTR,DEPT VIRUS DIS,WASHINGTON,DC 20307. SHEMYAKIN INST BIOORGAN CHEM,MOSCOW 117871,USSR. RP TSAREV, SA (reprint author), NIAID,HEPATITUS VIRUSES SECT,INFECT DIS LAB,BETHESDA,MD 20892, USA. RI Ticehurst, John/I-7532-2012 NR 36 TC 51 Z9 53 U1 0 U2 0 PU SOC GENERAL MICROBIOLOGY PI READING PA HARVEST HOUSE 62 LONDON ROAD, READING, BERKS, ENGLAND RG1 5AS SN 0022-1317 J9 J GEN VIROL JI J. Gen. Virol. PD JUL PY 1991 VL 72 BP 1677 EP 1683 DI 10.1099/0022-1317-72-7-1677 PN 7 PG 7 WC Biotechnology & Applied Microbiology; Virology SC Biotechnology & Applied Microbiology; Virology GA FW644 UT WOS:A1991FW64400022 PM 1649901 ER PT J AU SIMPSON, SL HERTZOG, MS BARJA, RH AF SIMPSON, SL HERTZOG, MS BARJA, RH TI THE PLANTARIS TENDON GRAFT - AN ULTRASOUND STUDY SO JOURNAL OF HAND SURGERY-AMERICAN VOLUME LA English DT Article AB To assess the value of ultrasound in imaging the plantaris tendon, ultrasounds were done on 26 legs in 25 patients who had a variety of surgical procedures on the posterior leg. Eighteen ultrasounds were done and interpreted before operation and eight after operation by a radiologist. The sonographic results were compared with the status of the plantaris as determined at surgery. The plantaris was present in 21 of 23 patients for a prevalence of 91%. Eighteen plantaris tendons were well visualized on ultrasound for a sensitivity of 86%. Of the three false-negative results, two occurred with thinned plantaris tendons that were less than 2 mm thick and hence considered inadequate for grafting. Therefore, the sensitivity for detecting a tendon suitable for grafting was 95%. All patients with positive studies had a plantaris tendon present for a specificity of 100%. A learning curve for the radiologist was demonstrated. Ultrasound appears to be effective in the preoperative imaging of the plantaris tendon. RP SIMPSON, SL (reprint author), EISENHOWER ARMY MED CTR,ORTHOPAED SURG SERV,FT GORDON,GA 30905, USA. NR 0 TC 20 Z9 21 U1 0 U2 5 PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS PI NEW YORK PA 650 AVENUE OF THE AMERICAS, NEW YORK, NY 10011 SN 0363-5023 J9 J HAND SURG-AM JI J. Hand Surg.-Am. Vol. PD JUL PY 1991 VL 16A IS 4 BP 708 EP 711 PG 4 WC Orthopedics; Surgery SC Orthopedics; Surgery GA FW765 UT WOS:A1991FW76500023 PM 1880370 ER PT J AU KOEPSELL, RW VALDES, JB AF KOEPSELL, RW VALDES, JB TI MULTIDIMENSIONAL RAINFALL PARAMETER-ESTIMATION FROM SPARSE NETWORK SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Article AB The multidimensional precipitation model proposed by Waymire et al. provides realistic representations of the rainfall process. The model, however, in its most simplified form requires the numerical evaluation of nine parameters. Islam et al. developed a parameter estimation procedure and they applied the methodology to a small experimental basin with a dense network of rain gauges. In this paper the same estimation procedure is attempted over a larger area where only a sparse rain-gauge network is available. Parameter estimates are determined for cyclonic-midlatitude and convective storms, which are characteristic of the winter and summer rain seasons over the test basin. Using the seasonal storm parameter estimates, multidimensional model storms are generated over the Brazos Valley in Texas, and the storms are assessed qualitatively. C1 TEXAS A&M UNIV SYST,DEPT METEOROL,COLLEGE STN,TX 77843. TEXAS A&M UNIV SYST, E15XCLIMATE SYSTEM RES PROGRAM,COLLEGE STN,TX 77843. TEXAS A&M UNIV SYST,DEPT CIVIL ENGN,COLLEGE STN,TX 77843. RP KOEPSELL, RW (reprint author), USA,INST SPACE,FT LEAVENWORTH,KS 66027, USA. NR 12 TC 7 Z9 7 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD JUL PY 1991 VL 117 IS 7 BP 832 EP 850 DI 10.1061/(ASCE)0733-9429(1991)117:7(832) PG 19 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA FU038 UT WOS:A1991FU03800002 ER PT J AU HELWEG, OJ JACOB, KP AF HELWEG, OJ JACOB, KP TI SELECTING OPTIMUM DISCHARGE RATE FOR WATER WELL SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Note C1 240TH QUARTERMASTER BATTAL,FT LEE,VA 23801. RP HELWEG, OJ (reprint author), MEMPHIS STATE UNIV,DEPT CIVIL ENGN,MEMPHIS,TN 38152, USA. NR 9 TC 3 Z9 3 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD JUL PY 1991 VL 117 IS 7 BP 934 EP 939 DI 10.1061/(ASCE)0733-9429(1991)117:7(934) PG 6 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA FU038 UT WOS:A1991FU03800009 ER PT J AU GRIFFISS, JM JARVIS, GA OBRIEN, JP EADS, MM SCHNEIDER, H AF GRIFFISS, JM JARVIS, GA OBRIEN, JP EADS, MM SCHNEIDER, H TI LYSIS OF NEISSERIA-GONORRHOEAE INITIATED BY BINDING OF NORMAL HUMAN-IGM TO A HEXOSAMINE-CONTAINING LIPOOLIGOSACCHARIDE EPITOPE(S) IS AUGMENTED BY STRAIN-SPECIFIC, PROPERDIN-BINDING-DEPENDENT ALTERNATIVE COMPLEMENT PATHWAY ACTIVATION SO JOURNAL OF IMMUNOLOGY LA English DT Article ID CAPSULAR POLYSACCHARIDE ANTIGEN; NUCLEAR MAGNETIC-RESONANCE; MENINGITIDIS SEROGROUP-Z; SIALIC-ACID; STRUCTURAL ELUCIDATION; SERUM SENSITIVITY; ESCHERICHIA-COLI; C3 CONVERTASE; ANTIBODY; LIPOPOLYSACCHARIDE AB We studied the specificity of naturally acquired IgM bactericidal for strains of Neisseria gonorrhoeae that varied in sensitivity to the lytic action of normal human serum (NHS) and the relative ability of these strains to deplete the classical (CP) and alternative (ACP) C pathways. Lysis of both highly sensitive and relatively insensitive strains was inhibited by the same gonococcal lipooligosaccharides (LOS), as well as by Salmonella minnesota Re LOS and three hexosamine-containing glycose polymers. A polymer of N-acetylgalactosamine phosphate was the most inhibitory; a polymer of N-acetylglucosamine phosphate only partially inhibited. Neither 3-deoxy-D-manno-octulosonic acid (dOclA) nor a polymer that contained dOc1A but not hexosamine inhibited NHS lysis. A co-polymer of N-acetylgalactosamine-dOc1A inhibited both bactericidal activity and the binding of IgM to the LOS of a highly serum-sensitive (ser(s)) gonococcal strain. Carboxyl reduction of the dOcIA in this polymer did not affect its inhibitory capacity for gonococcal antibody, but abolished its binding to homologous antibody induced by vaccination. CP activity was not affected by absorption of NHS with gonococcal strains, whereas ablation of CP activity markedly but variously diminished lytic activity for highly ser(s) strains. ACP activity was variously depleted by gonococcal strains, and the proportion of bacteria that could be lysed through the ACP varied among strains and among different populations of a given strain. The titer at which a strain was sensitive to NHS lysis was a function of its ACP consumption (p = 0.006), which accounted for 70% of the differences in titer among strains. Analyses of the absorbed sera revealed that the gonococci had variously depleted properdin from NHS as assessed by using an Ag-capture solid-phase RIA. Addition of purified properdin to absorbed sera restored ACP activity to normal levels. Western immunoblots of gonococcal lysates showed that purified properdin bound directly to a 39-kDa outer membrane protein. We conclude that both CP activation by IgM binding to LOS epitopes, one of which contains hexosamine, and ACP activation, which is a function of strain-specific direct binding of properdin, can initiate lysis of ser(s) strains and that ACP activation also enhances lysis and accounts for variations in sensitivity of ser(s) strains. C1 UNIV CALIF SAN FRANCISCO,DEPT MED,SAN FRANCISCO,CA 94143. UNIV CALIF SAN FRANCISCO,DEPT LAB MED,SAN FRANCISCO,CA 94143. UNIV CALIF SAN FRANCISCO,CTR IMMUNOCHEM,SAN FRANCISCO,CA 94143. BRIGHAM & WOMENS HOSP,DEPT MED,CHANNING LAB,BOSTON,MA 02115. VET ADM MED CTR JAMAICA PLAIN,DEPT RES & EDUC,INFECT DIS SECT,BOSTON,MA 02130. WALTER REED ARMY MED CTR,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. HARVARD UNIV,SCH MED,BOSTON,MA 02115. RP GRIFFISS, JM (reprint author), VET ADM MED CTR,113-A,4150 CLEMENT ST,SAN FRANCISCO,CA 94121, USA. FU NIAID NIH HHS [AI21620] NR 43 TC 39 Z9 39 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD JUL 1 PY 1991 VL 147 IS 1 BP 298 EP 305 PG 8 WC Immunology SC Immunology GA FT763 UT WOS:A1991FT76300045 PM 1711080 ER PT J AU OCKENHOUSE, CF HO, M TANDON, NN VANSEVENTER, GA SHAW, S WHITE, NJ JAMIESON, GA CHULAY, JD WEBSTER, HK AF OCKENHOUSE, CF HO, M TANDON, NN VANSEVENTER, GA SHAW, S WHITE, NJ JAMIESON, GA CHULAY, JD WEBSTER, HK TI MOLECULAR-BASIS OF SEQUESTRATION IN SEVERE AND UNCOMPLICATED PLASMODIUM-FALCIPARUM MALARIA - DIFFERENTIAL ADHESION OF INFECTED ERYTHROCYTES TO CD36 AND ICAM-1 SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID GLYCOPROTEIN-IV CD36; PARASITIZED ERYTHROCYTES; MEDIATES CYTOADHERENCE; MEMBRANE GLYCOPROTEIN; CEREBRAL MALARIA; T-CELLS; RECEPTOR; LIGAND; LFA-1; IDENTIFICATION AB The CD36 and ICAM-1 glycoproteins on vascular endothelial cells have been implicated as cytoadherence receptors for Plasmodium falciparum-infected erythrocytes (IRBC). Adhesion of IRBC from Thai patients with uncomplicated and severe falciparum malaria to purified CD36 or ICAM-1 and to C32 melanoma cells was compared. All malaria isolates bound to solid phase-adsorbed CD36 and to fluid-phase I-125-labeled CD36. IRBC adhesion to purified ICAM-1 varied widely, and no correlation with clinical severity of disease was observed. The cytoadherent phenotype of IRBC was modulated by selective panning on plates coated with purified CD36 or ICAM-1. IRBC selected by panning on CD36+, ICAM-1+ melanoma cells bound to cells that express surface CD36 but not to CD36-deficient cells, indicating that CD36 exerts a strong selective pressure on the IRBC cytoadherent phenotype. IRBC adhesion to CD36 and ICAM-1 suggests that P. falciparum parasites may use these receptors in vivo to promote parasite survival and immune evasion. C1 WALTER REED ARMY MED CTR,IMMUNOL BRANCH,WASHINGTON,DC 20307. AMER RED CROSS,CELL BIOL LAB,ROCKVILLE,MD. NCI,EXPTL IMMUNOL BRANCH,BETHESDA,MD 20892. USA,MED RES INST INFECT DIS,DIV VIROL,FREDERICK,MD 21701. UNIV CALGARY,DEPT MICROBIOL & INFECT DIS,CALGARY T2N 1N4,ALBERTA,CANADA. MAHIDOL UNIV,HOSP TROP DIS,FAC TROP MED,BANGKOK 10700,THAILAND. USA,MED COMPONENT,ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. RP OCKENHOUSE, CF (reprint author), WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307, USA. RI White, Nicholas/I-4629-2012 NR 31 TC 188 Z9 188 U1 0 U2 4 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JUL PY 1991 VL 164 IS 1 BP 163 EP 169 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA FT630 UT WOS:A1991FT63000024 PM 1711552 ER PT J AU KAIN, KC KEYSTONE, J FRANKE, ED LANAR, DE AF KAIN, KC KEYSTONE, J FRANKE, ED LANAR, DE TI GLOBAL DISTRIBUTION OF A VARIANT OF THE CIRCUMSPOROZOITE GENE OF PLASMODIUM-VIVAX SO JOURNAL OF INFECTIOUS DISEASES LA English DT Note ID SPOROZOITE VACCINE; PROTEIN; SAFETY; IMMUNOGENICITY AB The global distribution of a newly described variant of the Plasmodium vivax circumsporozoite (CS) gene was determined by genetic analysis of wild isolates. Whole blood specimens were collected on filter paper from patients infected with P. vivax in South America, West Africa, and the Indian subcontinent. P. vivax DNA was released from the filter paper samples, and the CS gene was amplified by polymerase chain reaction and analyzed for genetic variation. Amplified DNA was probed with oligonucleotide probes that hybridize with the predominant CS repeat region (PV210) and the variant CS repeat region (PV247) of P. vivax. The PV247 variant was found in all three geographically diverse areas. In addition, five of six consecutive patients studied had simultaneous infection with both the predominant and variant forms of P. vivax. These findings suggest that a single-epitope vaccine based on the predominant CS domain is unlikely to be protective on even a regional basis. C1 TORONTO GEN HOSP,TROP DIS UNIT,TORONTO M5G 1L7,ONTARIO,CANADA. USN,MED RES INST DETACHMENT,LIMA,PERU. RP KAIN, KC (reprint author), WALTER REED ARMY MED CTR,DEPT IMMUNOL,WASHINGTON,DC 20307, USA. RI Lanar, David/B-3560-2011; Villasante, Eileen/G-3602-2011 NR 8 TC 48 Z9 51 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JUL PY 1991 VL 164 IS 1 BP 208 EP 210 PG 3 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA FT630 UT WOS:A1991FT63000034 PM 2056208 ER PT J AU GREEN, SJ NACY, CA MELTZER, MS AF GREEN, SJ NACY, CA MELTZER, MS TI CYTOKINE-INDUCED SYNTHESIS OF NITROGEN-OXIDES IN MACROPHAGES - A PROTECTIVE HOST RESPONSE TO LEISHMANIA AND OTHER INTRACELLULAR PATHOGENS SO JOURNAL OF LEUKOCYTE BIOLOGY LA English DT Review ID MAMMALIAN NITRATE BIOSYNTHESIS; MURINE CUTANEOUS LEISHMANIASIS; MOUSE PERITONEAL-MACROPHAGES; NECROSIS FACTOR-ALPHA; L-ARGININE DEIMINASE; GROWTH FACTOR-BETA; NITRIC-OXIDE; ACTIVATED MACROPHAGES; INTERFERON-GAMMA; RESPIRATORY BURST RP GREEN, SJ (reprint author), WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,9620 MED CTR DR,SUITE 200,WASHINGTON,DC 20307, USA. NR 116 TC 253 Z9 254 U1 2 U2 8 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0741-5400 J9 J LEUKOCYTE BIOL JI J. Leukoc. Biol. PD JUL PY 1991 VL 50 IS 1 BP 93 EP 103 PG 11 WC Cell Biology; Hematology; Immunology SC Cell Biology; Hematology; Immunology GA FT156 UT WOS:A1991FT15600012 PM 2056250 ER PT J AU MEHR, Z POWERS, NR KONKOL, KA AF MEHR, Z POWERS, NR KONKOL, KA TI MYIASIS IN A WOUNDED SOLDIER RETURNING FROM PANAMA SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Note DE INSECTA; COCHLIOMYIA-HOMINIVORAX; HUMAN MYIASIS; INTRODUCTION AB An imported case of traumatic myiasis occurred in a soldier wounded during military action in Panama in December 1989 and evacuated to Brooke Army Medical Center, Fort Sam Houston, Texas. At the medical center, five larvae were removed from the scalp wound, reared to the adult stage, and identified as Cochliomyia hominivorax (Coquerel). Though this was the only reported case of wound myiasis of the 254 servicemen evacuated for medical treatment, this incident indicates a potential mechanism for the reintroduction of C. hominivorax into the United States. C1 BROOKE ARMY MED CTR,PREVENT MED SERV,FT SAM HOUSTON,TX 78234. NR 8 TC 9 Z9 10 U1 0 U2 0 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD JUL PY 1991 VL 28 IS 4 BP 553 EP 554 PG 2 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA FT648 UT WOS:A1991FT64800015 PM 1941919 ER PT J AU HUNT, RA AF HUNT, RA TI FACING THE PHOENIX - THE CIA AND THE POLITICAL DEFEAT OF THE UNITED-STATES IN VIETNAM - GRANT,Z SO JOURNAL OF MILITARY HISTORY LA English DT Book Review RP HUNT, RA (reprint author), USA,CTR MIL HIST,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 1 U2 1 PU VIRGINIA MILITARY INST PI LEXINGTON PA LEXINGTON, VA 24450 SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 1991 VL 55 IS 3 BP 428 EP 430 DI 10.2307/1985703 PG 3 WC History SC History GA FV764 UT WOS:A1991FV76400024 ER PT J AU BURMAN, KD ANDERSON, JH WARTOFSKY, L MONG, DP JELINEK, JJ AF BURMAN, KD ANDERSON, JH WARTOFSKY, L MONG, DP JELINEK, JJ TI SCINTIGRAPHIC ASSESSMENT OF THYROID-CANCER - REPLY SO JOURNAL OF NUCLEAR MEDICINE LA English DT Letter RP BURMAN, KD (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU SOC NUCLEAR MEDICINE INC PI RESTON PA 1850 SAMUEL MORSE DR, RESTON, VA 22090-5316 SN 0161-5505 J9 J NUCL MED JI J. Nucl. Med. PD JUL PY 1991 VL 32 IS 7 BP 1463 EP 1464 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA FV990 UT WOS:A1991FV99000040 ER PT J AU CROWLEY, JS AF CROWLEY, JS TI SHOULD HELICOPTER FREQUENT FLYERS WEAR HEAD PROTECTION - A STUDY OF HELMET EFFECTIVENESS SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID CRASHES; INJURY AB Flight helmets have been recommended as aircrew head protection since 1908, yet debate continues regarding their effectiveness. Estimates of helmet use in civilian helicopter aeromedical programs range from 6.5% to 13%. The effectiveness of the Army's SPH-4 flight helmet in reducing severe head injuries sustained during helicopter accidents was evaluated using the accident data base at the US Army Safety Center, Fort Rucker, Alabama. Analysis was restricted to severe (Class A) accidents that were at least partially survivable, using US Army Safety Center criteria. Occupants not wearing a protective helmet were significantly more likely to sustain severe and fatal head injuries than were occupants wearing the SPH-4 (RR = 3.8 and 6.3, respectively; P < .01). Unhelmeted noncockpit occupants were at higher risk of head injuries (RR = 5.3 and 7.5; P < .01). All personnel regularly participating in helicopter flight, civilian or military, should be equipped with protective headgear. C1 USA,CTR SAFETY,FT RUCKER,AL 36360. NR 20 TC 6 Z9 6 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD JUL PY 1991 VL 33 IS 7 BP 766 EP 769 DI 10.1097/00043764-199107000-00007 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA FX062 UT WOS:A1991FX06200003 PM 1890485 ER PT J AU CARLSON, DE CIOFFI, WG MASON, AD MCMANUS, WF PRUITT, BA AF CARLSON, DE CIOFFI, WG MASON, AD MCMANUS, WF PRUITT, BA TI EVALUATION OF SERUM VISCERAL PROTEIN-LEVELS AS INDICATORS OF NITROGEN-BALANCE IN THERMALLY INJURED PATIENTS SO JOURNAL OF PARENTERAL AND ENTERAL NUTRITION LA English DT Article ID ALBUMIN LEVELS; PREALBUMIN; NUTRITION AB The use of serum visceral protein concentrations as predictors of nitrogen balance was assessed during the first 4 weeks following thermal injury. The correlation between nitrogen balance and serum albumin was not significant. Statistically significant correlations were found between nitrogen balance and serum prealbumin, retinol-binding protein, and transferrin. However, even the best correlation (retinol-binding protein, r = 0.388) was too weak to permit prediction of nitrogen balance on the basis of the visceral protein concentration. The correlation between change in direction of nitrogen balance and change in direction of protein concentration over time showed all four visceral proteins to be poor predictors of change in nitrogen balance. The efficiency was less than 50% for each visceral protein. Stepwise multiple regression analysis performed to determine which indices were most closely correlated with nitrogen balance showed that a calculation using readily available information (nitrogen intake, postburn day, percent total body surface burned, and age) provided better prediction of nitrogen balance (r = 0.765) than any of the visceral protein concentrations. In view of these findings, measurement of serum visceral protein concentrations to monitor adequacy of nutritional support seems an unwarranted expense in patients with thermal injury. RP CARLSON, DE (reprint author), USA,INST SURG RES,LIB BRANCH,FT SAM HOUSTON,TX 78234, USA. NR 12 TC 17 Z9 18 U1 0 U2 0 PU AMER SOC PARENTERAL & ENTERAL NUTRITION PI SILVER SPRING PA 8630 FENTON STREET SUITE 412, SILVER SPRING, MD 20910 SN 0148-6071 J9 JPEN-PARENTER ENTER JI J. Parenter. Enter. Nutr. PD JUL-AUG PY 1991 VL 15 IS 4 BP 440 EP 444 DI 10.1177/0148607191015004440 PG 5 WC Nutrition & Dietetics SC Nutrition & Dietetics GA FX323 UT WOS:A1991FX32300015 PM 1895488 ER PT J AU KERNS, DG SCHEIDT, MJ PASHLEY, DH HORNER, JA STRONG, SL VANDYKE, TE AF KERNS, DG SCHEIDT, MJ PASHLEY, DH HORNER, JA STRONG, SL VANDYKE, TE TI DENTINAL TUBULE OCCLUSION AND ROOT HYPERSENSITIVITY SO JOURNAL OF PERIODONTOLOGY LA English DT Article DE DENTIN, SENSITIVE; DENTIN ANATOMY AND HISTOLOGY; SCALING; PLANING; TOOTH ROOT ID HYDRAULIC CONDUCTANCE; SMEAR LAYER; PERMEABILITY; INVITRO; SURFACES; ETIOLOGY; AGENTS; PAIN AB PREVIOUS STUDIES HAVE ESTABLISHED that root sensitivity is due in part to open dentinal tubules at the root surface. The purpose of this study was to longitudinally evaluate the occlusion of dentinal tubules by various clinical procedures including scaling and root planing and the application of potassium oxalate. A model was developed to evaluate dentinal surfaces in vivo. Six 2 mm x 3 mm sections were taken from the roots of extracted teeth immediately below the CEJ. One half of the treated dentin samples from each donor was incorporated into the removable denture worn by the donor and the other half served as baseline. The dentin samples were evaluated at 1 week by scanning electron microscopy. At day zero no open tubules were observed in any of the samples due to the presence of a smear layer or oxalate crystals. Evaluation of root planed samples revealed that by 7 days the tubules had re-opened. The samples which had been treated with potassium oxalate showed few oxalate crystals by 7 days revealing open tubules. Control samples were etched with EDTA and evaluated in the same manner. Although the number of tubules did not significantly change in the EDTA etched control samples, the diameter of the tubules dramatically decreased by 4 weeks. It can be concluded that the creation of a smear layer or application of oxalates to occlude dentinal tubules to reduce sensitivity are relatively short-lived. These procedures may provide patient comfort prior to natural occlusion of the tubules. C1 MED COLL GEORGIA,AUGUSTA,GA 30912. RP KERNS, DG (reprint author), USA,DENT ACT,PERIODONT RESIDENCY PROGRAM,FT GORDON,GA 30905, USA. NR 34 TC 89 Z9 95 U1 2 U2 8 PU AMER ACAD PERIODONTOLOGY PI CHICAGO PA 737 NORTH MICHIGAN AVENUE, SUITE 800, CHICAGO, IL 60611-2690 SN 0022-3492 J9 J PERIODONTOL JI J. Periodont. PD JUL PY 1991 VL 62 IS 7 BP 421 EP 428 PG 8 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA FW175 UT WOS:A1991FW17500002 PM 1920008 ER PT J AU ALLEYN, CD ONEAL, RB STRONG, SL SCHEIDT, MJ VANDYKE, TE MCPHERSON, JC AF ALLEYN, CD ONEAL, RB STRONG, SL SCHEIDT, MJ VANDYKE, TE MCPHERSON, JC TI THE EFFECT OF CHLORHEXIDINE TREATMENT OF ROOT SURFACES ON THE ATTACHMENT OF HUMAN GINGIVAL FIBROBLASTS INVITRO SO JOURNAL OF PERIODONTOLOGY LA English DT Article DE PERIODONTAL DISEASES SURGERY; CHLORHEXIDINE THERAPEUTIC USE; WOUND HEALING; CONNECTIVE TISSUE; GINGIVITIS DRUG THERAPY; FIBROBLASTS ID SUBGINGIVAL PLAQUE; DIRECT IRRIGATION; SURGERY AB CHLORHEXIDINE MOUTHRINSE IS A WIDELY used adjunct in periodontal therapy due to its bactericidal effects. The effect of this agent on chronic gingivitis and wound healing following surgical therapy in animals and humans has been favorable. The re-establishment of lost connective tissue attachment to the root surface following periodontal therapy is a desirable goal in which the ability of periodontal ligament fibroblasts to reattach to root surfaces of periodontally involved teeth is a critical event. Understanding the effect of chlorhexidine on fibroblast attachment will provide the rationale for its use during the healing phase of periodontal surgery. For this study, impacted third molars were sectioned into 4 pieces. Groups of 10 root pieces were exposed to 0.12% chlorhexidine or saline for 3 minutes followed by a distilled water rinse. The root pieces were incubated with human gingival fibroblasts (HGF) using standard tissue culture techniques for 1, 2, 4, 6, and 8 hours. HGF were prelabeled with 3H-thymidine to a standard specific activity. The surface area of each root piece was determined and the attached cells quantified by using scintillation spectroscopy. The number of cells per unit area was then calculated and the data expressed as cells/mm2. The repeated measures design was statistically analyzed by repeated measures analysis of variance. There was a significant difference between the number of attached cells in the chlorhexidine and the control groups (P < 0.001). Exposure of root surfaces to chlorhexidine significantly inhibits subsequent fibroblast attachment which may interfere with regeneration of the periodontium. Hence, the data suggest that efforts should be made to minimize chlorhexidine contact with the root surface with physical barriers. RP ALLEYN, CD (reprint author), USA,DENT ACT,PERIODONTAL RESIDENCY PROGRAM,FT GORDON,GA 30905, USA. FU NIDCR NIH HHS [DE06436, DE07908] NR 22 TC 12 Z9 12 U1 0 U2 0 PU AMER ACAD PERIODONTOLOGY PI CHICAGO PA 737 NORTH MICHIGAN AVENUE, SUITE 800, CHICAGO, IL 60611-2690 SN 0022-3492 J9 J PERIODONTOL JI J. Periodont. PD JUL PY 1991 VL 62 IS 7 BP 434 EP 438 PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA FW175 UT WOS:A1991FW17500004 PM 1920010 ER PT J AU LILLEY, JS AF LILLEY, JS TI OPTIMUM-GEOMETRIES FOR SCARFED PERFECT NOZZLES SO JOURNAL OF PROPULSION AND POWER LA English DT Article AB The results of an investigation to determine the optimum geometry for length constrained scarfed nozzles employing perfect expansion contours is presented. A scarfed perfect nozzle performance analysis, based on an axisymmetric flowfield mode and utilizing the method of characteristics solution technique, was developed. The performance model was utilized in an optimization procedure to determine, for a range of nozzle projected lengths, the optimum set of scarfed perfect nozzle geometries. For each projected length, the respective optimum nozzle geometry was selected to maximize motor axial thrust coefficient. The set of optimum scarfed nozzle geometries was compared against optimum length constrained scarfed nozzles employing conical expansion contours. The optimum scarfed perfect nozzle geometries generated by this investigation were specifically produced for utilization in a design methodology developed to minimize the length of tactical solid propellant propulsion systems. Used in conjunction with the design methodology, the results of the present investigation provide the designer with a means of further reducing propulsion system length. RP LILLEY, JS (reprint author), USA,MISSILE COMMAND,REDSTONE ARSENAL,AL 35898, USA. NR 5 TC 1 Z9 1 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0748-4658 J9 J PROPUL POWER JI J. Propul. Power PD JUL-AUG PY 1991 VL 7 IS 4 BP 586 EP 592 DI 10.2514/3.23366 PG 7 WC Engineering, Aerospace SC Engineering GA FY513 UT WOS:A1991FY51300018 ER PT J AU MCCARTNEY, JW AF MCCARTNEY, JW TI OSSEOINTEGRATED IMPLANT-SUPPORTED AND MAGNETICALLY RETAINED EAR PROSTHESIS - A CLINICAL REPORT SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. RP MCCARTNEY, JW (reprint author), WALTER REED ARMY MED CTR,ADL,WASHINGTON,DC 20307, USA. NR 2 TC 14 Z9 14 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD JUL PY 1991 VL 66 IS 1 BP 6 EP 9 DI 10.1016/0022-3913(91)90342-T PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA FU300 UT WOS:A1991FU30000002 PM 1941677 ER PT J AU MCNEME, SJ VONGONTEN, AS WOOLSEY, GD AF MCNEME, SJ VONGONTEN, AS WOOLSEY, GD TI EFFECTS OF LABORATORY DISINFECTING AGENTS ON COLOR STABILITY OF DENTURE ACRYLIC RESINS SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article AB This study determined the effects of chemical disinfecting agents on denture acrylic resins. Tested resins included the products CH Lucitone, Triad VLC, and Truliner. The disinfecting agents were sodium hypochlorite, Exspor, Cidex, and Wescodyne-D. Acrylic resin samples were placed in the various disinfecting agents and then evaluated for color changes at time intervals ranging from 15 minutes to 72 hours. No observable color change of any acrylic resin was seen before 2 hours. Both 1% sodium hypochlorite and 2% Cidex disinfectants produced the least discoloration of the acrylic resins, and Wescodyne-D disinfectant produced the most acrylic resin discoloration. Truliner resin discolored more than Triad VLC resin, and both underwent more color change than CH Lucitone resin. If manufacturers' recommended disinfecting times are followed, clinical and laboratory disinfection of acrylic resin dentures should cause no observable color change. C1 ADV EDUC PROGRAM GEN DENT,FT HOOD,TX. RP MCNEME, SJ (reprint author), USA,WASHINGTON,DC 20310, USA. NR 27 TC 20 Z9 28 U1 0 U2 2 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD JUL PY 1991 VL 66 IS 1 BP 132 EP 136 DI 10.1016/0022-3913(91)90359-5 PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA FU300 UT WOS:A1991FU30000019 PM 1941663 ER PT J AU BODAI, CF AF BODAI, CF TI EXPEDIENT AND EFFECTIVE INTERIM RESTORATIONS FOR COMPROMISED POSTERIOR TEETH SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Note C1 USA,WASHINGTON,DC 20310. NR 2 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD JUL PY 1991 VL 66 IS 1 BP 139 EP 140 DI 10.1016/0022-3913(91)90361-Y PG 2 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA FU300 UT WOS:A1991FU30000021 PM 1941665 ER PT J AU MIKHAIL, AG AF MIKHAIL, AG TI SPIKE-NOSED PROJECTILES - COMPUTATIONS AND DUAL FLOW MODES IN SUPERSONIC FLIGHT SO JOURNAL OF SPACECRAFT AND ROCKETS LA English DT Article ID BODIES AB This study was made to assess the capability of a computational fluid dynamic (CFD) method in adequately determining the aerodynamics coefficients for the unusual configurations of sharp-edged spike-nosed projectiles that are of interest to the U.S. Army. McCormack's time-dependent explicit scheme was used for the full Navier-Stokes equations, together with zonal gridding and overlapping approach. Three configurations were computed at Mach = 1.72 and zero incidence angle. The results are compared against wind-tunnel data. The flowfields computed are in agreement with wind-tunnel schlieren photographs, and the computed drag coefficients are within 2% of the wind-tunnel measurements. Two important issues are faced. First is the always existing possibility of a dual flow mode and which one is to occur under specific flow conditions. The second issue is the observed role of the turbulence level and numerical model in affecting the flow separation, and, thus, influencing a particular flow mode to numerically occur. This study demonstrates the successful applicability of the present approach to these untypical configurations and, thus, encourages further application to even more complex spike-nosed configurations, such as those with booms and fins. RP MIKHAIL, AG (reprint author), USA,BALLIST RES LAB,LABCOM,DIV LAUNCH & FLIGHT,ABERDEEN PROVING GROUND,MD 21005, USA. NR 23 TC 12 Z9 13 U1 2 U2 2 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0022-4650 J9 J SPACECRAFT ROCKETS JI J. Spacecr. Rockets PD JUL-AUG PY 1991 VL 28 IS 4 BP 418 EP 424 DI 10.2514/3.26261 PG 7 WC Engineering, Aerospace SC Engineering GA GB522 UT WOS:A1991GB52200008 ER PT J AU PATTERSON, JH AF PATTERSON, JH TI EFFECTS OF PEAK PRESSURE AND ENERGY OF IMPULSES SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID HAZARD AB Peak pressure has been one of the key parameters of impulse noise used to assess the hazard to hearing. It is used in most international noise exposure limits. France uses an A-weighted energy limit. There is a rough correspondence between peak pressure and the hazard to hearing for a given type of impulse noise. However, when the effects of different type of impulse are compared, this correspondence breaks down. One of alternate measures of impulse intensity is weighted energy. Weighted energy is appealing for a number of reasons. It does not depend on details of the pressure-time history such as the peak pressure and the more common duration measures. It should be easier to integrate with continuous or intermittent noise standards. It would make it easier to use standard hearing protector attenuation to estimate the hazard when a specific hearing protector is worn. articles and reports will be discussed. These reports lead to the conclusion that weighted energy is a more potent determiner of hearing hazard than peak pressure if spectral effects are controlled. RP PATTERSON, JH (reprint author), USA,AEROMED RES LAB,SENSORY RES DIV,FT RUCKER,AL 36362, USA. NR 12 TC 7 Z9 7 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD JUL PY 1991 VL 90 IS 1 BP 205 EP 208 DI 10.1121/1.401289 PG 4 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA FV280 UT WOS:A1991FV28000025 PM 1880290 ER PT J AU PRICE, GR KALB, JT AF PRICE, GR KALB, JT TI INSIGHTS INTO HAZARD FROM INTENSE IMPULSES FROM A MATHEMATICAL-MODEL OF THE EAR SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID WEAPONS IMPULSES; COCHLEA; CAT AB In order to provide insight into the mechanisms that operate in the ear when it is exposed to intense sounds, time and frequency domain mathematical models of the ear including significant nonlinearities in the middle ear were developed to trace energy flow from the free field to the inner ear and ultimately allow the calculation of basilar membrane displacement and a consequent hazard function. These models match the ear's behavior at low intensities and also reproduce many of the features of the data on hearing hazard from intense impulses. They provide critical insights into the loss mechanisms, suggest new strategies for protecting hearing as well as reducing hazard at the source and could also serve as a framework for a new, accurate, theoretically based method for rating hazard from intense sounds. RP PRICE, GR (reprint author), USA,HUMAN ENGN LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 30 TC 43 Z9 45 U1 0 U2 5 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD JUL PY 1991 VL 90 IS 1 BP 219 EP 227 DI 10.1121/1.401291 PG 9 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA FV280 UT WOS:A1991FV28000027 PM 1880292 ER PT J AU SPERLING, LC AF SPERLING, LC TI HAIR ANATOMY FOR THE CLINICIAN SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID DISORDERS AB The rational evaluation of hair disorders requires familiarity with follicular anatomy. Hair structure can be easily examined by studying clipped hair shafts, entire hairs gently pulled or forcibly plucked from the scalp, and scalp biopsies (sectioned vertically or transversely). Anatomic features will be different depending on whether a given hair is in the anagen, catagen, or telogen phase. Follicle size will also vary, from the minute vellus hair to the long, thick terminal hair. Each follicle can be divided into distinct regions - bulb, suprabulbar zone, isthmus, and infundibulum. Activity growing (anagen) hairs are characterized by a hair matrix surrounding a dermal papilla; inner and outer root sheaths are present and well developed. A catagen hair can be identified by its markedly thickened vitreous layer and fibrous root sheath, which surrounds an epithelial column; above this column, the presumptive club forms. A telogen hair is distinguished by its fully keratinized club, which is surrounded by an epithelial sac. Below this lies the secondary hair germ and condensed dermal papilla, waiting for the mysterious signal that initiates a new life cycle. RP SPERLING, LC (reprint author), WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307, USA. NR 16 TC 85 Z9 88 U1 0 U2 11 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD JUL PY 1991 VL 25 IS 1 BP 1 EP 17 DI 10.1016/0190-9622(91)70167-Z PN 1 PG 17 WC Dermatology SC Dermatology GA FV333 UT WOS:A1991FV33300001 PM 1880235 ER PT J AU GREGORY, OJ ZETO, RJ HRYCKOWIAN, E BURBANK, KA AF GREGORY, OJ ZETO, RJ HRYCKOWIAN, E BURBANK, KA TI FABRICATION OF HIGH-CONDUCTIVITY, TRANSPARENT ELECTRODES WITH TRENCHED METAL BUS LINES SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID FILMS AB A novel transparent electrode system has been developed for thin film electroluminescent displays in which the poor conductivity of the indium-tin-oxide (ITO) electrodes has been augmented by high-conductivity buses of thick aluminum or silver. The augmented electrode system consists of patterned ITO electrodes, 200-mu-m wide, centered over narrow aluminum or silver lines 40-mu-m wide and separated by an intermediate diffusion barrier film of titanium to promote adhesion to the ITO and prevent blackening of the main ITO electrode by interfacial reactions. The sheet resistances of the augmented ITO electrodes (Al-Ti-ITO and Ti-Ag-Ti-ITO) were lowered by two orders of magnitude relative to the unaugmented ITO electrodes, yielding absolute values on the order of 0.1-OMEGA/s. C1 USA,LABCOM,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. UNIV RHODE ISL,DEPT CHEM & MAT ENGN,KINGSTON,RI 02881. RP GREGORY, OJ (reprint author), UNIV RHODE ISL,DEPT CHEM & MAT ENGN,KINGSTON,RI 02881, USA. NR 14 TC 1 Z9 1 U1 1 U2 2 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 10 SOUTH MAIN STREET, PENNINGTON, NJ 08534 SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PD JUL PY 1991 VL 138 IS 7 BP 2070 EP 2075 DI 10.1149/1.2085926 PG 6 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA FW341 UT WOS:A1991FW34100037 ER PT J AU BAUMAN, R AF BAUMAN, R TI AN EXPERIMENTAL-ANALYSIS OF THE COST OF FOOD IN A CLOSED ECONOMY SO JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR LA English DT Article DE BEHAVIORAL ECONOMICS; CLOSED ECONOMY; DEMAND; COST; DELAY; LEVER PRESS; RAT ID BEHAVIORAL ECONOMICS; CONSTRAINTS; RATS AB Rats lived in individual chambers in which the only food available was delivered for lever pressing. During Stage I, a fixed number of presses was required for each food pellet. As this fixed ratio of presses per food pellet was increased daily, a rat's daily intake of food was reduced. During Stage II, the cost of a food pellet was increased by replacing each fixed ratio with its interval equivalent. Each interval was a rat's mean time between the first press of a ratio and the delivery of a pellet during Stage I. During Stage II, only two presses were every required for a food pellet: The first press initiated a delay and the second activated the pellet dispenser after that delay elapsed. Food intakes for the series of fixed ratios and a rat's series of delay equivalents were very similar when plotted as a function of delay, but not when plotted as a function of presses per pellet. Consequently, the fixed ratio reduced food intake because larger ratios increased delay to food from the first press of a ratio. Observations and an analysis of interresponse times further revealed that as the fixed ratio increased, and local as well as overall rate of food intake decreased, lever pressing became more stereotyped. Because this increased stereotypy resulted in greatly increased rates of lever pressing, delay to food was minimized, and perhaps more importantly, so too was the reduction of a rat's baseline daily intake. RP BAUMAN, R (reprint author), WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,DIV NP,PHYSIOL & BEHAV BRANCH,WASHINGTON,DC 20307, USA. NR 17 TC 39 Z9 40 U1 0 U2 1 PU SOC EXP ANALYSIS BEHAVIOR INC PI BLOOMINGTON PA INDIANA UNIV DEPT PSYCHOLOGY, BLOOMINGTON, IN 47405 SN 0022-5002 J9 J EXP ANAL BEHAV JI J. Exp. Anal. Behav. PD JUL PY 1991 VL 56 IS 1 BP 33 EP 50 DI 10.1901/jeab.1991.56-33 PG 18 WC Psychology, Biological; Behavioral Sciences; Psychology, Experimental SC Psychology; Behavioral Sciences GA FW373 UT WOS:A1991FW37300003 PM 1940762 ER PT J AU DUBEY, JP SPEER, CA HAMIR, AN TOPPER, MJ BROWN, C RUPPRECHT, CE AF DUBEY, JP SPEER, CA HAMIR, AN TOPPER, MJ BROWN, C RUPPRECHT, CE TI DEVELOPMENT OF A SARCOCYSTIS-LIKE APICOMPLEXAN PROTOZOAN IN THE BRAIN OF A RACCOON (PROCYON-LOTOR) SO JOURNAL OF THE HELMINTHOLOGICAL SOCIETY OF WASHINGTON LA English DT Note DE PROTOZOA; APICOMPLEXA; COCCIDIA; SARCOCYSTIS; ENCEPHALITIS; SCHIZONTS; MEROZOITES AB Schizonts of a Sarcocystis-like protozoan were found in the brain of a raccoon (Procyon lotor). The parasites, located directly in the cytoplasm of macrophages, neurons, and multinucleated giant cells, were not surrounded by a parasitophorous vacuole. The parasite divided by endopolygeny, leaving a residual body. Schizonts were 5-35 x 5-20-mu-m and contained up to 35 merozoites. The merozoites had no rhoptries. The parasite was antigenically and structurally similar to Sarcocystis neurona, the organism of equine protozoal myeloencephalitis. C1 MONTANA STATE UNIV,BOZEMAN,MT 59717. UNIV PENN,NEW BOLTON CTR,SCH VET MED,KENNETT SQ,PA 19348. USA,MED RES INST INFECT DIS,FT DETRICK,MD 21702. WISTAR INST,PHILADELPHIA,PA 19104. RP DUBEY, JP (reprint author), USDA ARS,BELTSVILLE AGR RES CTR,INST LIVESTOCK & POULTRY SCI,ZOONOT DIS LAB,BARC E,BELTSVILLE,MD 20705, USA. NR 5 TC 12 Z9 12 U1 0 U2 1 PU HELMINTHOLOGICAL SOC WASHINGTON PI LAWRENCE PA C/O ALLEN PRESS INC, 1041 NEW HAMPSHIRE ST, LAWRENCE, KS 66044 SN 1049-233X J9 J HELMINTHOL SOC W JI J. Helminthol. Soc. Wash. PD JUL PY 1991 VL 58 IS 2 BP 250 EP 255 PG 6 WC Parasitology; Zoology SC Parasitology; Zoology GA GD363 UT WOS:A1991GD36300017 ER PT J AU LIPP, LJ AF LIPP, LJ TI DESIGN CONSIDERATION OF EXPANDER HEADS FOR VIBRATION TESTING .3. THE INVERTED TRUNCATED PYRAMID EXPANDING HEAD SO JOURNAL OF THE IES LA English DT Article DE EXPANDER HEAD; VIBRATION TEST FIXTURE; TEST FIXTURE RESONANCE; TEST FIXTURE DAMPING RP LIPP, LJ (reprint author), USA,ARMAMENT MUNIT & CHEM COMMAND,ABERDEEN PROVING GROUND,MD 21010, USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU INST ENVIRONMENTAL SCI PI MT PROSPECT PA 940 E NORTHWEST HIGHWAY, MT PROSPECT, IL 60056 SN 1052-2883 J9 J IES JI J. IES PD JUL-AUG PY 1991 VL 34 IS 4 BP 39 EP 46 PG 8 WC Engineering, Environmental; Environmental Sciences; Instruments & Instrumentation SC Engineering; Environmental Sciences & Ecology; Instruments & Instrumentation GA GB224 UT WOS:A1991GB22400006 ER PT J AU JOHNS, JP PUPA, LE BAILEY, SR AF JOHNS, JP PUPA, LE BAILEY, SR TI SPONTANEOUS THROMBOSIS OF IATROGENIC FEMORAL-ARTERY PSEUDOANEURYSMS - DOCUMENTATION WITH COLOR DOPPLER AND 2-DIMENSIONAL ULTRASONOGRAPHY SO JOURNAL OF VASCULAR SURGERY LA English DT Article ID DUPLEX; COMPLICATIONS; INJURIES; REPAIR; US AB Two-dimensional ultrasonography and color Doppler were used over an 18-month period for the diagnosis and management of femoral artery pseudoaneurysms in six patients with pulsatile groin masses found after catheterization. A diagnosis of pseudoaneurysm was made when color Doppler demonstrated pulsatile systolic flow into echolucent masses. One patient underwent surgical repair of a symptomatic pseudoaneurysm after the initial Doppler study. Serial color Doppler studies were performed in five subjects, all of whom showed resolution of flow after a mean of 18 days (range 7 to 42). Despite an absence of flow, one patient underwent surgical drainage of persistent hematoma. After a mean interval of 233 days (range 84 to 552) all patients have remained free of other complications or symptoms related to the pseudoaneurysm. This experience suggests that urgent surgical repair is not required in all cases of small iatrogenic pseudoaneurysms, and that asymptomatic patients can be safely followed with serial color Doppler examinations. RP JOHNS, JP (reprint author), BROOKE ARMY MED CTR,DEPT MED,SERV CARDIOL,FT SAM HOUSTON,TX 78234, USA. NR 16 TC 57 Z9 57 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD JUL PY 1991 VL 14 IS 1 BP 24 EP 29 PG 6 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA FW525 UT WOS:A1991FW52500003 PM 2061957 ER PT J AU GENDELMAN, HE EHRLICH, GD BACA, LM CONLEY, S RIBAS, J KALTER, DC MELTZER, MS POIESZ, BJ NARA, P AF GENDELMAN, HE EHRLICH, GD BACA, LM CONLEY, S RIBAS, J KALTER, DC MELTZER, MS POIESZ, BJ NARA, P TI THE INABILITY OF HUMAN-IMMUNODEFICIENCY-VIRUS TO INFECT CHIMPANZEE MONOCYTES CAN BE OVERCOME BY SERIAL VIRAL PASSAGE INVIVO SO JOURNAL OF VIROLOGY LA English DT Article ID LYMPHADENOPATHY-ASSOCIATED VIRUS; T-LYMPHOTROPIC RETROVIRUSES; SEROLOGICAL RESPONSES; PERSISTENT INFECTION; AIDS; PATHOGENESIS; MACROPHAGES; ENVELOPE; TRANSMISSION; REPLICATION AB Studies of lentivirus infection in ruminants, nonhuman primates, and humans suggest that virus infection of macrophages plays a central role in the disease process. To investigate whether human immunodeficiency virus type 1 (HIV-1) can infect chimpanzee macrophages, we recovered monocytes from peripheral blood mononuclear cells of HIV-1-negative animals and inoculated these and control human monocytes with a panel of four human-passaged monocytotropic virus strains and one chimpanzee-passaged isolate. HIV-1-infected human monocytes synthesized proviral DNA, viral mRNA, p24 antigen, and progeny virions. In contrast, except for the chimpanzee-passaged HIV-1 isolate, chimpanzee monocytes failed to support HIV-1 replication when cultured under both identical and a variety of other conditions. Proviral DNA was demonstrated only at background levels in these cell cultures by polymerase chain reaction for gag- and env-related sequences. Interestingly, the chimpanzee-passaged HIV-1 isolate did not replicate in human monocytes; viral p24 antigens and progeny virions were not detected. The same monocytotropic panel of HIV-1 strains replicated in both human and chimpanzee CD4+ T lymphoblasts treated with phytohemagglutinin and interleukin-2. The failure of HIV-1 to infect chimpanzee monocytes, which can be overcome by serial in vivo viral passage, occurs through a block early in the viral life cycle. C1 NCI,FREDERICK CANC RES DEV CTR,TUMOR CELL BIOL LAB,VIRUS BIOL SECT,FREDERICK,MD 21701. HENRY M JACKSON FDN ADV MIL MED,ROCKVILLE,MD 20852. WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,HIV IMMUNOPATHOGENESIS PROGRAM,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,WASHINGTON,DC 20306. SUNY HLTH SCI CTR,DIV HEMATOL & ONCOL,SYRACUSE,NY 13210. NCI,PROGRAM RESOURCES INC,FREDERICK,MD 21701. FU NCI NIH HHS [N01-CO-74102]; NHLBI NIH HHS [N01-HB-67021] NR 37 TC 36 Z9 36 U1 2 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD JUL PY 1991 VL 65 IS 7 BP 3853 EP 3863 PG 11 WC Virology SC Virology GA FQ940 UT WOS:A1991FQ94000053 PM 1674968 ER PT J AU SMITH, ER KRAUS, NC AF SMITH, ER KRAUS, NC TI LABORATORY STUDY OF WAVE-BREAKING OVER BARS AND ARTIFICIAL REEFS SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article AB One-hundred eight regular-wave tests and 12 random-wave tests were performed in a tank to investigate properties of waves breaking on irregular beach profiles. In the tests, solid objects representing natural barred profiles, terraced profiles, and artificial reefs were installed on a concrete slope of 1/30. Wave conditions covered deep-water steepnesses from 0.0085 to 0.09. A large data base of previous measurements of wave breaking on plane slopes was also compiled and analyzed for comparison to the barred profile measurements. Significant differences were found in such properties as breaker type, breaker depth and height indices, plunge distance, and splash distance for plane and barred slopes. The ratio of wave height and water depth of random waves transforming over a bar was not constant, as previously reported from field measurements, but showed a bimodal distribution with maxima of approximately unity at the bar crest and foreshore and minima of approximately 0.45 in the offshore and bar trough. RP SMITH, ER (reprint author), USA,COASTAL ENGN RES CTR,WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 23 TC 39 Z9 39 U1 1 U2 3 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD JUL-AUG PY 1991 VL 117 IS 4 BP 307 EP 325 DI 10.1061/(ASCE)0733-950X(1991)117:4(307) PG 19 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA FU257 UT WOS:A1991FU25700001 ER PT J AU LARSON, M KRAUS, NC AF LARSON, M KRAUS, NC TI NUMERICAL-MODEL OF LONGSHORE-CURRENT FOR BAR AND TROUGH BEACHES SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article ID INCIDENT SEA WAVES; FIELD DATA AB This paper describes a numerical modeling system called NMLONG that was developed to calculate the wave height, wave direction, mean water level, and steady-state time-averaged longshore current velocity across a multiple bar and trough beach profile. The modeling system includes the longshore current and change in mean water surface elevation produced by waves and wind, lateral mixing, wave driving by monochromatic or random waves as options, linear or quadratic bottom friction law as options, and wave-current interaction as an option. The principal requirement for use of the model is longshore uniformity in bathymetry and waves. Verification against laboratory and field measurements of the wave height, longshore current, and mean water surface elevation (laboratory only) indicates that default values of the model calibration parameters should be acceptable for most engineering applications. Techniques are employed to minimize computer execution time, including efficient time averaging of the nonlinear bottom friction stress and a skillful first approximation in the iterative solution of the longshore current using the nonlinear bottom friction law, allowing the model to run effectively on a desktop computer. C1 USA,COASTAL ENGN RES CTR,WATERWAYS EXPT STN,VICKSBURG,MS 39180. RP LARSON, M (reprint author), UNIV LUND,INST SCI & TECH,DEPT WATER RESOUR ENGN,BOX 118,S-22100 LUND,SWEDEN. NR 28 TC 45 Z9 53 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD JUL-AUG PY 1991 VL 117 IS 4 BP 326 EP 347 DI 10.1061/(ASCE)0733-950X(1991)117:4(326) PG 22 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA FU257 UT WOS:A1991FU25700002 ER PT J AU MCCARTNEY, BL HERRMANN, FA SIMMONS, HB AF MCCARTNEY, BL HERRMANN, FA SIMMONS, HB TI ESTUARY WATERWAY PROJECTS - LESSONS LEARNED SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article AB Most major ports in the United States (and the world) are located in tidal estuaries. Access to these ports generally requires development of dredged channels. The maintenance of these channels can be affected by many factors such as channel location, training works, dredged material disposal practices, and salinity changes. This paper provides a list of do's and don'ts for design and maintenance of estuary navigation projects. The estuaries are classified into two general zones; entrance channels and interior channels. Entrance channel lessons include jetty configuration, location and length, dredging methods, and dredge material disposal practices. Interior channel lessons cover harbor and interior channel locations, location of salinity caused shoaling, dredging methods and dredge material disposal practices. The do's and don'ts list is a condensation of lessons learned from studies of 24 estuary navigation projects in the United States. The lessons are generic, therefore site-specific evaluations would be required to determine their applicability. C1 USA,WATERWAYS EXPT STN,HYDR LAB,VICKSBURG,MS 39180. RP MCCARTNEY, BL (reprint author), USA,DIV ENGN,N PACIFIC,220 NW 8TH AVE,PORTLAND,OR 97208, USA. NR 1 TC 1 Z9 1 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD JUL-AUG PY 1991 VL 117 IS 4 BP 409 EP 421 DI 10.1061/(ASCE)0733-950X(1991)117:4(409) PG 13 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA FU257 UT WOS:A1991FU25700006 ER PT J AU JAMES, WF BARKO, JW AF JAMES, WF BARKO, JW TI LITTORAL-PELAGIC PHOSPHORUS DYNAMICS DURING NIGHTTIME CONVECTIVE CIRCULATION SO LIMNOLOGY AND OCEANOGRAPHY LA English DT Article ID LAKE; SEDIMENTS; SHALLOW; MACROPHYTES; WISCONSIN; EXCHANGE; ALBERTA; WATER AB Littoral phosphorus dynamics and P exchanges between littoral and pelagic zones, driven by nighttime convective circulation, were examined in Eau Galle Reservoir, Wisconsin, during summer 1989. Rates of P release from littoral sediments, measured in laboratory incubation systems, increased linearly with pH under both aerobic and anaerobic conditions. Estimated rates of P release from littoral sediments, based on field measurements of pH and oxygen, averaged 3.6 mg m-2 d-1 under aerobic conditions and were in close agreement with independently determined diffusional fluxes across the littoral-sediment interface. Marked vertical gradients in P developed during summer in bottom waters of the littoral zone. The littoral zone cooled more rapidly at night than the pelagic zone on 72% of midsummer days (June-August), promoting nighttime convective circulation. On the basis of patterns of dye dispersion during these periods of circulation, cooler littoral bottom water moved into the pelagic zone as an interflow confined to the base of the epilimnion, while warmer pelagic water moved into the littoral zone as a surface flow. Hourly volumetric flow rates were linearly related to mean negative horizontal temperature gradients that developed at night. Net total P flux from the littoral to the pelagic zone ranged from 0. 12 to 0.43 Mg m-2 h-1 (avg. 0.22) for the summer. Nighttime convective circulation seems to be an important mechanism for movement of littoral P to the pelagic zone in this reservoir. C1 ENVIRONM LAB,WATERWAYS EXPT STN,VICKSBURG,MS 39180. NR 18 TC 30 Z9 30 U1 0 U2 4 PU AMER SOC LIMNOLOGY OCEANOGRAPH PI LAWRENCE PA 810 EAST 10TH ST, LAWRENCE, KS 66044-8897 SN 0024-3590 J9 LIMNOL OCEANOGR JI Limnol. Oceanogr. PD JUL PY 1991 VL 36 IS 5 BP 949 EP 960 PG 12 WC Limnology; Oceanography SC Marine & Freshwater Biology; Oceanography GA GP594 UT WOS:A1991GP59400010 ER PT J AU KNOWLES, SC DAVIS, RA AF KNOWLES, SC DAVIS, RA TI HURRICANE-INDUCED CARBONATE ENRICHMENT OF A HOLOCENE COASTAL BAY SEQUENCE, SARASOTA BAY, FLORIDA SO MARINE GEOLOGY LA English DT Article AB Sarasota Bay is a shallow, somewhat ovoid coastal bay, landward of a Holocene barrier complex on the west-central, microtidal Gulf of Mexico coast of Florida. The general stratigraphy of the west Florida coastal area consists of a thin veneer of Quaternary siliciclastic sand overlying Tertiary carbonates and argillaceous materials. Biogenic carbonate debris is typically less than 10% by weight of the total volume of coastal sand. Due to lack of significant fluvial influence and source material, coupled with higher energy levels than adjacent bays, mineral mud deposition within Sarasota Bay has been minor; consequently, continuous infilling of the bay has not occurred. Instead, the passage of major hurricanes has resulted in sporadic, event-related deposition. At least three major hurricanes are represented within the bay stratigraphy. Major hurricanes opened inlets and deposited a Storm Facies within the bay. The Graded Storm Facies comprises conspicuously fining-upward units of highly porous, sandy shell-gravel to slightly shelly quartz sand, formed by rapid deposition as sediment-charged water passed into the bay through inlets. The Homogeneous Storm Facies comprises mixed shelly sand units formed from reworking of Graded Storm Facies or older deposits. Storm Facies, which contain about 42wt% bioclastic carbonate, dominate central bay areas, and have resulted in significant carbonate enrichment of the total bay sediment complex. Transgression of quartz-sand dominated Barrier Island Facies across the bay may preserve basal carbonate-enriched facies and result in a coastal bay sequence in which the mean grain size and carbonate content generally decrease upward. C1 UNIV S FLORIDA,DEPT GEOL,TAMPA,FL 33715. RP KNOWLES, SC (reprint author), USA CORPS ENGINEERS,WATERWAYS EXPT STN,HYDRAULICS LAB,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 35 TC 3 Z9 3 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0025-3227 J9 MAR GEOL JI Mar. Geol. PD JUL PY 1991 VL 99 IS 1-2 BP 151 EP 161 DI 10.1016/0025-3227(91)90088-L PG 11 WC Geosciences, Multidisciplinary; Oceanography SC Geology; Oceanography GA GD144 UT WOS:A1991GD14400010 ER PT J AU HORNG, S KAHN, A WRENN, C PFEFFER, R AF HORNG, S KAHN, A WRENN, C PFEFFER, R TI GROWTH OF GAAS/CA0.45SR0.55F2/GAAS STRUCTURES BY MOLECULAR-BEAM EPITAXY SO MATERIALS SCIENCE AND ENGINEERING B-SOLID STATE MATERIALS FOR ADVANCED TECHNOLOGY LA English DT Article; Proceedings Paper CT 1990 FALL MEETING OF THE EUROPEAN MATERIALS RESEARCH SOC CY NOV 27-30, 1990 CL STRASBOURG, FRANCE SP EUROPEAN MAT RES SOC ID FILMS AB Lattice-matched GaAs/Ca0.45Sr0.55F2/GaAs structures are grown by molecular beam epitaxy on GaAs(100) substrates. The surface morphology and crystallinity of each layer are studied as a function of growth temperature. The best fluoride layers are grown with a substrate temperature of about 530-degrees-C and show excellent crystallinity (chi-min = 7% in ion channeling). The best GaAs layers are obtained around 600-degrees-C and show medium bulk crystallinity (chi-min = 30%). Electron beam irradiation of the fluoride surface considerably improves the GaAs surface morphology. C1 USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07724. RP HORNG, S (reprint author), PRINCETON UNIV,DEPT ELECT ENGN,PRINCETON,NJ 08544, USA. NR 15 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0921-5107 J9 MAT SCI ENG B-SOLID JI Mater. Sci. Eng. B-Solid State Mater. Adv. Technol. PD JUL PY 1991 VL 9 IS 1-3 BP 263 EP 267 DI 10.1016/0921-5107(91)90184-W PG 5 WC Materials Science, Multidisciplinary; Physics, Condensed Matter SC Materials Science; Physics GA GC545 UT WOS:A1991GC54500047 ER PT J AU HICKMAN, CJ STOVER, CK JOSEPH, SW OAKS, EV AF HICKMAN, CJ STOVER, CK JOSEPH, SW OAKS, EV TI MOLECULAR-CLONING AND SEQUENCE-ANALYSIS OF A RICKETTSIA-TSUTSUGAMUSHI 22 KDA ANTIGEN CONTAINING B-CELL AND T-CELL EPITOPES SO MICROBIAL PATHOGENESIS LA English DT Article DE RICKETTSIA TSUTSUGAMUSHI; T-CELL ANTIGEN; STA22; SCRUB TYPHUS FEVER ID PROTEIN ANTIGENS; SCRUB TYPHUS; GENE; DNA; IDENTIFICATION; RESPONSES; NITROCELLULOSE; COMPONENTS; INFECTION; ANTIBODY C1 WALTER REED ARMY MED CTR,DEPT RICKETTSIAL DIS,WASHINGTON,DC 20307. UNIV MARYLAND,DEPT MICROBIOL,COLLEGE PK,MD 20742. NR 39 TC 12 Z9 14 U1 0 U2 0 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0882-4010 J9 MICROB PATHOGENESIS JI Microb. Pathog. PD JUL PY 1991 VL 11 IS 1 BP 19 EP 31 DI 10.1016/0882-4010(91)90090-W PG 13 WC Immunology; Microbiology SC Immunology; Microbiology GA GK808 UT WOS:A1991GK80800003 PM 1724548 ER PT J AU PERLMAN, BS AF PERLMAN, BS TI MICROWAVE TECHNOLOGY AND DEVICE RESEARCH IN THE ARMY SO MICROWAVE JOURNAL LA English DT Article AB This article highlights specific Army Lab activities, initiatives and accomplishments that enhance and enable many tactical defense capabilities and substantially influence modern warfare. Increased awareness and knowledge of what the Army Labs are doing and thinking is appropriate and timely as it affects research, corporate investment, education and development of our industrial technology base. With a little imagination, this technology can be used for peaceful applications for the benefit of society. Therefore, it is appropriate that the long term impact of government sponsored basic research and exploratory development be viewed from an application perspective. RP PERLMAN, BS (reprint author), USA,LABCOM,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU HORIZON HOUSE-MICROWAVE PI NORWOOD PA 685 CANTON ST, NORWOOD, MA 02062 SN 0192-6225 J9 MICROWAVE J JI Microw. J. PD JUL PY 1991 VL 34 IS 7 BP 81 EP 85 PG 5 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA FX882 UT WOS:A1991FX88200003 ER PT J AU GUNDERSON, CH AF GUNDERSON, CH TI ADMINISTRATIVE MANAGEMENT OF THE SOLDIER WITH SEIZURES SO MILITARY MEDICINE LA English DT Article AB Based on improvement in our understanding of the prognosis of young adults with new onset seizures, and cumulative experience with the rules in effect for the last 30 years, a substantial change in the regulations affecting the fitness and profiling of these soldiers has been made. In general, these liberalize retention and profiling, set limits on the duration of trials of duty, provide for fitness determinations in soldiers with pseudo-seizures, and specify when neurologic consultation is required. RP GUNDERSON, CH (reprint author), WALTER REED ARMY MED CTR,NEUROL SERV,WASHINGTON,DC 20307, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 1991 VL 156 IS 7 BP 328 EP 330 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA FW957 UT WOS:A1991FW95700007 PM 1922841 ER PT J AU RIDGLEY, CD WILKINS, JR AF RIDGLEY, CD WILKINS, JR TI A COMPARISON OF MEDIAN HEARING THRESHOLDS FROM UNITED-STATES-NAVY AND UNITED-STATES-ARMY AUDIOMETRIC DATA-BASES SO MILITARY MEDICINE LA English DT Article AB This study examined 1984 monitoring audiometric data from U.S. Navy (military and civilian) employees whose workplace required a mandatory hearing conservation program. Median hearing thresholds were compared in U.S. Navy employees, U.S. Army employees also monitored by a hearing conservation program, and a standard population from the First National Health and Nutrition Survey. Age group and frequency-specific comparisons were included. Results at 4 kHz and 6 kHz demonstrated higher median thresholds in the Navy populations that were significantly higher by clinical and statistical criteria. Possible reasons for the differences are given. RP RIDGLEY, CD (reprint author), USA,ENVIRONM HYG AGCY,DIV OCCUPAT & ENVIRONM MED,ABERDEEN PROVING GROUND,MD 21010, USA. NR 0 TC 5 Z9 5 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 1991 VL 156 IS 7 BP 343 EP 345 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA FW957 UT WOS:A1991FW95700010 PM 1922844 ER PT J AU COMPTON, AB JONES, FD AF COMPTON, AB JONES, FD TI CLINICAL-FEATURES OF YOUNG-ADULT HISPANIC PSYCHIATRIC-INPATIENTS - THE SO-CALLED PUERTO-RICAN SYNDROME SO MILITARY MEDICINE LA English DT Article AB Among 118 young Hispanic (101 Puerto Rican) psychiatric inpatients, somatic complaints, violence, suicidal tendency, hallucinations, sudden onset of symptoms, and dissociative behavior each occurred in 46% or more of patients. There was no difference in clinical presentation between island Puerto Rican patients and Puerto Rican patients raised on the mainland. There was no relationship between these behaviors and any specific psychiatric disorder. Although there is a suggestion that more of these behaviors may occur among Puerto Rican Hispanics, further study with larger control groups is needed. RP COMPTON, AB (reprint author), WALTER REED ARMY MED CTR,DEPT PSYCHIAT,WASHINGTON,DC 20307, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 1991 VL 156 IS 7 BP 351 EP 354 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA FW957 UT WOS:A1991FW95700012 PM 1922846 ER PT J AU ROSEN, LN MOGHADAM, LZ AF ROSEN, LN MOGHADAM, LZ TI PREDICTORS OF GENERAL WELL BEING AMONG ARMY WIVES SO MILITARY MEDICINE LA English DT Article AB Predictors of general well being were examined in a sample of Army wives who participated in the second and third iterations of the Unit Manning System Family Health Study. Nine variables measured at time 1 (including social supports, personality, domains of life satisfaction, and military life stress) and two aspects of husbands' duty schedule measured at time 2 were regressed on general well being (GWB) measured at time 2. Significant predictors of GWB at time 2 included GWB at time 1, personality, and predictability of husband's schedule at time 2. When GWB at time 1 was excluded from the model, other significant predictors emerged, including financial satisfaction, marital satisfaction, and number of days in the past 6 months that husband was away in the field. RP ROSEN, LN (reprint author), WALTER REED ARMY MED CTR,DEPT MIL PSYCHIAT,SGRD,UWI,A,WASHINGTON,DC 20307, USA. NR 0 TC 5 Z9 5 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 1991 VL 156 IS 7 BP 357 EP 361 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA FW957 UT WOS:A1991FW95700014 PM 1922848 ER PT J AU PFAFF, JA PIMENTEL, L AF PFAFF, JA PIMENTEL, L TI CHLAMYDIAL ANTIGEN TESTING ON FEMALE-PATIENTS PRESENTING TO THE EMERGENCY DEPARTMENT SO MILITARY MEDICINE LA English DT Article AB We prospectively determined the prevalence of Chlamydia trachomatis infection in patients presenting to an emergency department over a 4-month period who received pelvic exams. We compared the percentage of cases of Chlamydia diagnosed by the Chlamydiazyme immunoassay with the percentage diagnosed clinically by emergency physicians. Over the study period, 326 pelvic exams were performed. Of 36 patients (11%) with positive tests, 16(44%) were treated clinically for pelvic inflammatory disease. Twenty (56%) received neither appropriate antibiotic treatment nor a gynecology referral based on clinical exam alone. We statistically evaluated the data using the hypothesis test for two proportions from one group. The difference was significant (Z = 4.6, p < 0.001). RP PFAFF, JA (reprint author), WOMACK ARMY MED CTR,DEPT EMERGENCY MED,FT BRAGG,NC 28307, USA. NR 0 TC 6 Z9 6 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 1991 VL 156 IS 7 BP 362 EP 364 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA FW957 UT WOS:A1991FW95700015 PM 1922849 ER PT J AU REID, DS NIMBKAR, NV RODRIQUEZ, M AF REID, DS NIMBKAR, NV RODRIQUEZ, M TI MELANOMA METASTATIC TO BREAST SO MILITARY MEDICINE LA English DT Article AB A patient presented with an unusual case of a breast mass. History and meticulous physical examination led to the diagnosis of metastatic melanoma, which was confirmed by biopsy. The differential diagnosis of metastasis to breast is discussed. RP REID, DS (reprint author), WALTER REED ARMY MED CTR,PLAST SURG SERV,WASHINGTON,DC 20307, USA. NR 0 TC 5 Z9 5 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 1991 VL 156 IS 7 BP 367 EP 368 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA FW957 UT WOS:A1991FW95700017 PM 1922851 ER PT J AU TRACY, DG ZALOZNIK, AJ AF TRACY, DG ZALOZNIK, AJ TI PRIMARY CARDIAC ANGIOSARCOMA - A REVIEW AND CASE-REPORT SO MILITARY MEDICINE LA English DT Review AB Primary cardiac tumors, both benign and malignant, are rare. Approximately 25% of primary cardiac tumors are malignant, with the majority of these being sarcomas. One of the most common sarcomas is angiosarcoma. A case of primary angiosarcoma of the heart is presented which illustrates several of the features of this malignancy. The administration of systemic chemotherapy resulted in a brief stabilization of disease before progression and subsequent death occurred. Clinical signs and symptoms of cardiac tumors and diagnostic testing are discussed. Therapeutic options and efficacy of therapy are reviewed. C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 1991 VL 156 IS 7 BP 372 EP 374 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA FW957 UT WOS:A1991FW95700019 PM 1922853 ER PT J AU JEFFER, EL AF JEFFER, EL TI MEDICAL UNITS - WHO SHOULD COMMAND - REPLY SO MILITARY MEDICINE LA English DT Letter RP JEFFER, EL (reprint author), USA,MC,WASHINGTON,DC 20310, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 1991 VL 156 IS 7 BP A5 EP A6 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA FW957 UT WOS:A1991FW95700003 ER PT J AU KENDRICK, DB AF KENDRICK, DB TI MEDICAL UNITS - WHO SHOULD COMMAND SO MILITARY MEDICINE LA English DT Letter RP KENDRICK, DB (reprint author), USA,MC,WASHINGTON,DC 20310, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 1991 VL 156 IS 7 BP A7 EP A7 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA FW957 UT WOS:A1991FW95700005 PM 1922839 ER PT J AU WILLIAMS, JM GONZALES, A QUINTANA, J LEE, IS BUCHANAN, RA BURNS, FC CULBERTSON, RJ LEVY, M TREGLIO, JR AF WILLIAMS, JM GONZALES, A QUINTANA, J LEE, IS BUCHANAN, RA BURNS, FC CULBERTSON, RJ LEVY, M TREGLIO, JR TI ION-IMPLANTATION FOR CORROSION INHIBITION OF ALUMINUM-ALLOYS IN SALINE MEDIA SO NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS LA English DT Article; Proceedings Paper CT 7TH INTERNATIONAL CONF ON ION BEAM MODIFICATION OF MATERIALS ( IBMM 90 ) CY SEP 09-14, 1990 CL KNOXVILLE, TN AB The effects of ion implantation treatments on corrosion of 2014 and 1100 aluminum in saline media were investigated. Implanted constituents were N, Si, Ti, and Cr. Techniques included salt spray testing, electrochemical studies, Rutherford backscattering spectrometry, and profilometry. The principal conclusion was that ion implantation of Cr is of potential practical benefit for corrosion inhibition of 2014 Al in salt environments. C1 AVSCOM,DERSO,CORPUS CHRISTI,TX. CORPUS CHRISTI ARMY DEPOT,CORPUS CHRISTI,TX. UNIV TENNESSEE,KNOXVILLE,TN 37996. USA,MAT TECHNOL LAB,WATERTOWN,MA 02172. ISM TECHNOL INC,SAN DIEGO,CA. RP WILLIAMS, JM (reprint author), OAK RIDGE NATL LAB,OAK RIDGE,TN 37831, USA. NR 5 TC 18 Z9 18 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-583X J9 NUCL INSTRUM METH B JI Nucl. Instrum. Methods Phys. Res. Sect. B-Beam Interact. Mater. Atoms PD JUL PY 1991 VL 59 BP 845 EP 850 DI 10.1016/0168-583X(91)95717-R PN 2 PG 6 WC Instruments & Instrumentation; Nuclear Science & Technology; Physics, Atomic, Molecular & Chemical; Physics, Nuclear SC Instruments & Instrumentation; Nuclear Science & Technology; Physics GA FZ030 UT WOS:A1991FZ03000030 ER PT J AU COWIE, JG LOWDER, LJ CULBERTSON, RJ KOSIK, WE BROWN, R AF COWIE, JG LOWDER, LJ CULBERTSON, RJ KOSIK, WE BROWN, R TI REDUCED HYDROGEN EMBRITTLEMENT SUSCEPTIBILITY IN PLATINUM IMPLANTED HIGH-STRENGTH STEEL SO NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS LA English DT Article; Proceedings Paper CT 7TH INTERNATIONAL CONF ON ION BEAM MODIFICATION OF MATERIALS ( IBMM 90 ) CY SEP 09-14, 1990 CL KNOXVILLE, TN AB High strength steels suffer from a high susceptibility to hydrogen embrittlement in a corrosive atmosphere, a factor which limits their usefulness. A good catalyst, such as platinum, present on the surface of the steel may lead to a low value of hydrogen overvoltage, thereby reducing the accumulation and subsequent diffusion of atomic hydrogen into the metal. In the present study, platinum was implanted into high strength electroslag remelted (ESR) 4340 steel specimens to a dose of 10(16) atoms/cm2. Both Pt-implanted and unimplanted specimens were rate charged with hydrogen. The relative concentration of diffusible hydrogen was determined using an electrochemical measurement device known as a Barnacle Electrode. The specimens implanted with platinum exhibited less diffusible hydrogen than the unimplanted steel. Slow strain rate notched-tensile tests, in an aqueous solution of 3.5 wt.% NaCl, were performed in order to evaluate the effect of hydrogen on strength and ductility. The Pt-implanted specimens were able to sustain significantly higher loads before fracture than their unimplanted counterparts. Scanning electron microscopy (SEM) verified the presence of brittle cracking typical of hydrogen embrittlement type failures. Degradation of mechanical properties due to hydrogen embrittlement was thus significantly reduced. This suggested that both the electrochemical and catalytic properties of the Pt-implanted surface were responsible for the improvement in properties. C1 UNIV RHODE ISL,KINGSTON,RI 02881. RP COWIE, JG (reprint author), USA,MAT TECHNOL LAB,WATERTOWN,MA 02172, USA. NR 5 TC 0 Z9 0 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-583X J9 NUCL INSTRUM METH B JI Nucl. Instrum. Methods Phys. Res. Sect. B-Beam Interact. Mater. Atoms PD JUL PY 1991 VL 59 BP 871 EP 874 DI 10.1016/0168-583X(91)95722-P PN 2 PG 4 WC Instruments & Instrumentation; Nuclear Science & Technology; Physics, Atomic, Molecular & Chemical; Physics, Nuclear SC Instruments & Instrumentation; Nuclear Science & Technology; Physics GA FZ030 UT WOS:A1991FZ03000035 ER PT J AU WARD, JA JOHNSON, JM AF WARD, JA JOHNSON, JM TI PLANNING SAMPLE SIZES - COMPARISON OF FACTOR LEVEL MEANS SO NURSING RESEARCH LA English DT Letter RP WARD, JA (reprint author), BROOKE ARMY MED CTR,DEPT CLIN INVEST,FT SAM HOUSTON,TX 78234, USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU AMER J NURSING CO PI NEW YORK PA 555 W 57TH ST, NEW YORK, NY 10019-2961 SN 0029-6562 J9 NURS RES JI Nurs. Res. PD JUL-AUG PY 1991 VL 40 IS 4 BP 235 EP & PG 0 WC Nursing SC Nursing GA FZ157 UT WOS:A1991FZ15700011 PM 1857650 ER PT J AU MCHALE, KA GEISSELE, A PERLIK, PD AF MCHALE, KA GEISSELE, A PERLIK, PD TI COMPARTMENT SYNDROME OF THE BICEPS BRACHII COMPARTMENT FOLLOWING RUPTURE OF THE LONG HEAD OF THE BICEPS SO ORTHOPEDICS LA English DT Article RP MCHALE, KA (reprint author), WALTER REED ARMY MED CTR,PEDIAT ORTHOPED,WASHINGTON,DC 20307, USA. NR 0 TC 16 Z9 16 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0147-7447 J9 ORTHOPEDICS JI Orthopedics PD JUL PY 1991 VL 14 IS 7 BP 787 EP 788 PG 2 WC Orthopedics SC Orthopedics GA FU501 UT WOS:A1991FU50100009 PM 1871030 ER PT J AU MORIN, GV SHANK, EC BURGESS, LPA HEFFNER, DK AF MORIN, GV SHANK, EC BURGESS, LPA HEFFNER, DK TI ONCOCYTIC METAPLASIA OF THE PHARYNX SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article ID LARYNX; TUMORS AB Oncocytic metaplasia of the pharynx has been infrequently described, with only two previous cases in the literature. With the advent of panendoscopy during the last decade, however, a better understanding of this histopathologic diagnosis is desirable. Thirty-three cases are reviewed, with thirty occurring in the nasopharynx. This was most commonly discovered as an unrelated finding during endoscopic evaluation of a head and neck mass or malignancy in twenty-two patients, either histologically after random biopsy or after biopsy of small but visible lesions. An additional eight cases manifested otitis media or eustachian tube dysfunction. The histology, terminology, and benign clinical nature of these lesions are discussed. C1 ARMED FORCES INST PATHOL,DEPT OTOLARYNG PATHOL,WASHINGTON,DC 20306. WALTER REED ARMY MED CTR,OTOLARYNGOL HEAD & NECK SURG SERV,WASHINGTON,DC 20307. NR 9 TC 10 Z9 10 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD JUL PY 1991 VL 105 IS 1 BP 86 EP 91 PG 6 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA FW818 UT WOS:A1991FW81800012 PM 1909013 ER PT J AU MELTZER, MS BACA, L TURPIN, JA KALTER, DC DIEFFENBACH, C FRIEDMAN, RM GENDELMAN, HE AF MELTZER, MS BACA, L TURPIN, JA KALTER, DC DIEFFENBACH, C FRIEDMAN, RM GENDELMAN, HE TI REGULATION OF CYTOKINE AND VIRAL GENE-EXPRESSION IN MONOCYTES INFECTED WITH THE HUMAN-IMMUNODEFICIENCY-VIRUS SO PATHOBIOLOGY LA English DT Article DE MONOCYTES; HUMAN IMMUNODEFICIENCY VIRUS; INTERFERON; CYTOKINES ID TUMOR-NECROSIS-FACTOR; INTERFERON-ALPHA; MONONUCLEAR-CELLS; GAMMA-INTERFERON; HIV REPLICATION; IFN-ALPHA; MACROPHAGES; PATHOGENESIS; INDUCE AB Monocytes treated with interferon-alpha (IFN-alpha) at virus challenge show no evidence of human immunodeficiency virus (HIV) infection: no p24 antigen or reverse transcriptase (RT) activity, no viral mRNA and no proviral DNA. Levels of p24 antigen and RT activity in monocytes infected with HIV 1-3 weeks before IFN-alpha treatment gradually decrease to baseline. HIV-induced cytopathic changes are markedly reduced, as are levels of HIV mRNA: the frequency of productively infected cells is less-than-or-equal-to 1 %. But, levels of proviral DNA in the IFN-alpha-treated and control HIV-infected cells are indistinguishable, and remain so through 3 weeks. Large quantities of proviral DNA in IFN-alpha-treated cells with little active transcription suggest true microbiological latency. The major potential source for IFN-alpha in HIV-infected patients is the macrophage. With any of 15 virus isolates, tumor necrosis factor-alpha, interleukin-1-beta, interleukin-6, IFN-omega or IFN-beta are not detected nor the mRNA expressed in HIV-infected or uninfected monocytes. Both uninfected and HIV-infected monocytes produce high levels of these cytokines after treatment with synthetic double-stranded RNA (poly-I:C). Uninfected monocytes also produce high levels of IFN-alpha after treatment with Poly-I:C, Newcastle disease virus or herpes simplex virus. In marked contrast, HIV-infected monocytes express no IFN-alpha activity or mRNA before or after treatment with any of these agents. The markedly diminished capacity of HIV-infected monocyte to produce IFN-alpha reflects a specific transcriptional block and may be an adaptive mechanism of virus to alter basic microbicidal functions of this cell. The inevitable result of this HIV-induced cytokine dysregulation is virus replication and persistence in mononuclear phagocytes. C1 WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,IMMUNOPATHOGENESIS PROGRAM,WASHINGTON,DC 20307. HENRY M JACKSON FDN ADVANCEMENT MIL MED,ROCKVILLE,MD. UNIFORMED SERV UNIV HLTH SCI,DEPT PATHOL,BETHESDA,MD 20814. NR 20 TC 6 Z9 6 U1 0 U2 0 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1015-2008 J9 PATHOBIOLOGY JI Pathobiology PD JUL-AUG PY 1991 VL 59 IS 4 BP 209 EP 213 DI 10.1159/000163647 PG 5 WC Cell Biology; Pathology SC Cell Biology; Pathology GA FP849 UT WOS:A1991FP84900001 PM 1883515 ER PT J AU ROBINSON, CP FRANZ, DR AF ROBINSON, CP FRANZ, DR TI EFFECTS OF PALYTOXIN ON GUINEA-PIG TRACHEAL STRIPS SO PHARMACEUTICAL RESEARCH LA English DT Article DE PALYTOXIN; TRACHEA; POTASSIUM DEPLETION; SMOOTH MUSCLE CONTRACTIONS; GUINEA PIGS ID VASCULAR SMOOTH-MUSCLE; CONTRACTILE ACTION; INHIBITORY-ACTION; RELAXANT FACTOR; EPITHELIUM; AORTA; MECHANISM; RESPONSIVENESS; REACTIVITY; CARTILAGE AB The effects of palytoxin (PTX) on airway smooth muscle were investigated in opened rings of guinea pig trachea. Concentrations of PTX from 10 pM to 100 nM caused contractions of tracheal strips, with maximal contractions approximately 80% of those in response to 120 mM potassium. Tension increased to its maximum in approximately 5 min with 100 nM PTX, then decreased to or near resting tension over the next 60 min. Contractions were larger when the epithelium was removed. Exposure to high (100 nM) concentrations of PTX markedly reduced subsequent contractions to PTX but had less effect on potassium-induced contractions. In zero-calcium solution the rate of contraction was slowed but the maximal contraction was not reduced. The addition of a calcium channel blocker (verapamil) markedly reduced the contractions and a calcium chelator (EGTA) abolished them. Contractions to PTX in zero-calcium media suggested that tracheal cartilage was serving as a calcium source, as it has been previously reported to do. Potassium removal and sodium reduction also greatly reduced contractions. These data are consistent with other observations suggesting that PTX may form pores through which sodium leaks into the cell. PTX was also found to differ from ouabain in its mode of action. C1 USA,MED RES INST INFECT DIS,DIV PATHOPHYSIOL,FREDERICK,MD 21701. RP ROBINSON, CP (reprint author), UNIV OKLAHOMA,HLTH SCI CTR,COLL PHARM,OKLAHOMA CITY,OK 73190, USA. NR 36 TC 2 Z9 2 U1 0 U2 0 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0724-8741 J9 PHARMACEUT RES JI Pharm. Res. PD JUL PY 1991 VL 8 IS 7 BP 859 EP 864 DI 10.1023/A:1015895227196 PG 6 WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy SC Chemistry; Pharmacology & Pharmacy GA FV055 UT WOS:A1991FV05500008 PM 1681529 ER PT J AU LEVY, A KONG, RM STILLMAN, MJ SHUKITTHALE, B KADAR, T RAUCH, TM LIEBERMAN, HR AF LEVY, A KONG, RM STILLMAN, MJ SHUKITTHALE, B KADAR, T RAUCH, TM LIEBERMAN, HR TI NIMODIPINE IMPROVES SPATIAL WORKING MEMORY AND ELEVATES HIPPOCAMPAL ACETYLCHOLINE IN YOUNG-RATS SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR LA English DT Note DE NIMODIPINE; SPATIAL MEMORY; LEARNING; HIPPOCAMPUS; ACETYLCHOLINE; MICRODIALYSIS; CALCIUM CHANNELS ID BLOCKER NIMODIPINE; AGING RABBITS; BAY-E-9736; DAMAGE; DRUG AB The calcium channel blocker nimodipine has been reported to improve cognitive performance in aged and brain-damaged animals. In the present study, the effects of nimodipine and placebo on spatial working memory and hippocampal acetylcholine were studied in young Fischer-344 rats. Nimodipine or placebo was administered via subcutaneously implanted, sustained-release pellets. Each active pellet contained 20 mg of nimodipine and released the drug over approximately 21 days. Two days after the drug or placebo pellets were implanted, training in the 8-arm radial maze started and continued for 12 days. Rats were required to learn a win-shift strategy. Nimodipine-treated animals learned the maze more rapidly than a placebo-treated group as indicated by the number of correct choices out of the first eight arms visited (p < 0.001). Treated rats also made twice as many choices per unit time during the first week of training (p = 0.005). To assess hippocampal acetylcholine release, in vivo microdialysis was performed while animals were awake and unrestrained, 19-21 days after pellet implantation. A probe with a 3 mm semipermeable tip was placed in the hippocampus (CA1 and dentate gyrus), and individual mu-l dialysate samples were collected at 2-mu-l/min and immediately analyzed by high performance liquid chromatography with electrochemical detection. Significantly higher extracellular ACh levels were found in nimodipine-treated rats (71.4 +/- 3.6 nM; n = 4) compared to controls (52.5 +/- 2.5 nM; n = 5) (p = 0.003) and in another group of rats of the same age that received identical drug treatment. It appears that sustained nimodipine treatment improves working memory and increases extracellular acetylcholine release in the hippocampus of young rats. C1 USA,ENVIRONM MED RES INST,DIV MIL PERFORMANCE & NEUROSCI DISORDERS,SGRD-UE-OPS,NATICK,MA 01760. GEOCENTERS INC,NEWTON CTR,MA 02159. NR 25 TC 62 Z9 63 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0091-3057 J9 PHARMACOL BIOCHEM BE JI Pharmacol. Biochem. Behav. PD JUL PY 1991 VL 39 IS 3 BP 781 EP 786 DI 10.1016/0091-3057(91)90164-W PG 6 WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy GA GD543 UT WOS:A1991GD54300038 PM 1784606 ER PT J AU YEH, SY HSU, FL AF YEH, SY HSU, FL TI THE NEUROCHEMICAL AND STIMULATORY EFFECTS OF PUTATIVE METABOLITES OF 3,4-METHYLENEDIOXYAMPHETAMINE AND 3,4-METHYLENEDIOXYMETHAMPHETAMINE IN RATS SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR LA English DT Note DE NEUROTOXICITY; LOCOMOTOR ACTIVITY; MDA; MDMA; 5-HT; 5-HIAA; ALPHA-METHYLDOPAMINE; ALPHA-METHYLNOREPINEPHRINE; ALPHA-METHYLEPINEPHRINE; 4-HYDROXY-3-METHOXYAMPHETAMINE ID METHYLENEDIOXYAMPHETAMINE MDA; METHYLENEDIOXYMETHAMPHETAMINE; BRAIN; MDMA; AMPHETAMINE; SEROTONIN; TERMINALS; IDENTIFICATION; NEUROTOXICITY; INVIVO AB Rats were injected SC with a dose of 10 mg/kg (as base) of 3,4-methylenedioxyamphetamine (MDA), or 3,4-methylenedioxymethamphetamine (MDMA), 4-hydroxy-3-methoxyamphetamine, alpha-methyldopamine and alpha-methylnorepinephrine, metabolites of MDA, and alpha-methlepinephrine, a putative metabolite of MDMA, twice daily for either 5 or 7 consecutive doses. The rats were killed 24 h after the last injection and monoamines in discrete brain regions were assayed. MDA, MDMA, 4-hydroxy-3-methoxyamphetamine and alpha-methyldopamine, but not alpha-methylepinephrine, decreased the concentration of serotonin (5-HT) in the frontal cortex. MDA and MDMA, but not 4-hydroxy-3-methoxyamphetamine, alpha-methyldopamine and alpha-methylepinephrine, also decreased the concentration of 5-hydroxyindoleacetic acid (5-HIAA) in the frontal cortexes. In stimulatory studies, MDA and MDMA, but not their metabolites except alpha-methylepinephrine, which increased activity at 15 and 30 min, increased locomotor activity from 15 to 180 min following the drug administration. C1 USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. RP YEH, SY (reprint author), NIDA,ADDICT RES CTR,POB 5180,BALTIMORE,MD 21224, USA. NR 25 TC 18 Z9 18 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0091-3057 J9 PHARMACOL BIOCHEM BE JI Pharmacol. Biochem. Behav. PD JUL PY 1991 VL 39 IS 3 BP 787 EP 790 DI 10.1016/0091-3057(91)90165-X PG 4 WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy GA GD543 UT WOS:A1991GD54300039 PM 1723801 ER PT J AU BAUMAN, RA PRZYBELSKI, RJ BOUNDS, MJ AF BAUMAN, RA PRZYBELSKI, RJ BOUNDS, MJ TI THE EFFECTS OF ALPHA-ALPHA CROSS-LINKED HEMOGLOBIN ON THE FEEDING AND LOCOMOTOR-ACTIVITY OF RATS SO PHYSIOLOGY & BEHAVIOR LA English DT Article DE BLOOD SUBSTITUTES; ALPHA-ALPHA CROSS-LINKED HEMOGLOBIN; HEMORRHAGIC SHOCK; BEHAVIORAL TOXICITY ID ACTIVITY-STRESS ULCER; BLOOD SUBSTITUTE; MAZE PERFORMANCE AB The feeding and locomotor activities of rats were used as an assay for the potentially toxic effects of an oxygen-carrying blood substitute. Rats lived in individual cages where they could feed ad lib by pressing a lever once for each small food pellet, drink water, or run in a wheel; a 12-h light/dark cycle was continuously in effect. After being anesthetized and hemorrhaged one-third of their total blood volume, individual rats were resuscitated with one of the following fluids: their own shed blood (OB), bis(3,5-dibromosalicylfumarate) alpha-alpha-cross-linked hemoglobin (HbXL), human serum albumin (HSA), or Ringer's lactate (RL). Rats in a fifth group were not resuscitated (NR). During the dark period on the day of hemorrhage, the food intake and running activity of rats in all groups decreased. Food intake and locomotor activity of rats in the HbXL, NR and OB groups were more suppressed than the HSA or RL groups. The food intake of rats in the HbXL and NR groups remained significantly more suppressed during the dark period of the first recovery day; running continued to be suppressed in the HbXL group on the first recovery day, but not the second recovery day. In an effort to determine the extent to which the rats in the HbXL group were impaired, an increasing number of lever presses was required for each food pellet beginning with recovery day number 3 for all treatment groups. As the ratio of presses per pellet was increased, food intake decreased and running increased for all groups; no differences between groups were significant. The initial impairment of feeding and running in the HbXL group supports the utility of the present procedure as a sensitive bioassay for the potentially toxic effects of hemoglobin substitutes on behavior. The subsequent absence of significant differences between groups during the increasing series of fixed ratios suggests that the effects of alpha-alpha-HbXL on feeding and running were not lasting. C1 USA,MED RES UNIT EUROPE,APO,NEW YORK,NY 09102. STN HOSP 130,APO,NEW YORK,NY 09102. RP BAUMAN, RA (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT MED NEUROSCI,PHYSIOL & BEHAV BRANCH,WASHINGTON,DC 20307, USA. NR 25 TC 2 Z9 2 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0031-9384 J9 PHYSIOL BEHAV JI Physiol. Behav. PD JUL PY 1991 VL 50 IS 1 BP 205 EP 211 DI 10.1016/0031-9384(91)90522-P PG 7 WC Psychology, Biological; Behavioral Sciences SC Psychology; Behavioral Sciences GA GC294 UT WOS:A1991GC29400034 PM 1946718 ER PT J AU LEDFORD, FF AF LEDFORD, FF TI TODAYS MASH SO POSTGRADUATE MEDICINE LA English DT Letter RP LEDFORD, FF (reprint author), USA,MED CORPS,FALLS CHURCH,VA, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU MCGRAW HILL HEALTHCARE PUBLICATIONS PI MINNEAPOLIS PA 4530 WEST 77TH ST, MINNEAPOLIS, MN 55435-5000 SN 0032-5481 J9 POSTGRAD MED JI Postgrad. Med. PD JUL PY 1991 VL 90 IS 1 BP 39 EP 39 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA FX065 UT WOS:A1991FX06500006 ER PT J AU KRASKO, GL OLSON, GB AF KRASKO, GL OLSON, GB TI EFFECT OF HYDROGEN ON THE ELECTRONIC-STRUCTURE OF A GRAIN-BOUNDARY IN IRON SO SOLID STATE COMMUNICATIONS LA English DT Article ID EMBEDDED-ATOM METHOD; FE-B ALLOYS; INTERGRANULAR EMBRITTLEMENT; SEGREGATION; METALS; PHOSPHORUS; COHESION; MODEL; HEATS AB LMTO-ASA calculations were performed on a 26-atom supercell model of a SIGMA-3 (111) grain boundary (GB) in bcc Fe. The supercell emulated two GB's with 11 (111) planes of Fe atoms between the GB planes. One of the GB's was clean, with a structural vacancy at the GB core in the center of a trigonal prism of Fe atoms, while on the other GB this site was occupied by a H atom. The interplanar spacings of the supercell were relaxed using a modified embedded atom method. As in the case of P and S in a similar GB environment in Fe there is only a weak interaction between H and nearest Fe atoms. Almost all the Fe d-states are nonbonding. A very weak covalent bond exists between H and Fe due to s-pd hybridization, the hybrid bonding band located far below the Fermi energy. This bond is mostly of sigma-type, connecting H with the Fe atoms in the GB plane; the delta-component of this bond across the GB is weaker. Contrary to a general belief, H on the GB does not contribute any significant electron charge to Fe valence d-bands. A weak electrostatic interaction attracts Fe-atoms across the clean GB, but results in repulsion if a H atom is present. The magnetic contribution to intergranular cohesion is decreased when H is present due to the suppression of the magnetic moments of the nearest Fe atoms both in the GB plane and directly across the GB. C1 NORTHWESTERN UNIV,DEPT MAT SCI & ENGN,EVANSTON,IL 60208. RP KRASKO, GL (reprint author), USA,MAT TECHNOL LAB,MET RES BRANCH,WATERTOWN,MA 02172, USA. RI Olson, Gregory/B-7529-2009 NR 39 TC 32 Z9 33 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0038-1098 J9 SOLID STATE COMMUN JI Solid State Commun. PD JUL PY 1991 VL 79 IS 2 BP 113 EP 117 DI 10.1016/0038-1098(91)90072-4 PG 5 WC Physics, Condensed Matter SC Physics GA FX473 UT WOS:A1991FX47300003 ER PT J AU KAWABUCHI, M CINTRA, WM DESHPANDE, SS ALBUQUERQUE, EX AF KAWABUCHI, M CINTRA, WM DESHPANDE, SS ALBUQUERQUE, EX TI MORPHOLOGICAL AND ELECTROPHYSIOLOGICAL STUDY OF DISTAL MOTOR-NERVE FIBER DEGENERATION AND SPROUTING AFTER IRREVERSIBLE CHOLINESTERASE INHIBITION SO SYNAPSE LA English DT Article DE NEUROMUSCULAR JUNCTION; CHOLINESTERASE INHIBITION; ORGANOPHOSPHATE POISONING; NERVE DEGENERATION; SPROUTING ID NEUROMUSCULAR-JUNCTION; ORGANOPHOSPHOROUS NEUROPATHY; ANTICHOLINESTERASE AGENTS; AXONAL DEGENERATION; INDUCED MYOPATHY; END-PLATES; RAT; MUSCLES; ACETYLCHOLINE; DIAPHRAGM AB A single subcutaneous injection of a sublethal dose of the irreversible organophosphate sarin (0.08 mg/kg) in rats induced a non-Wallerian-type axonal degeneration of the neuromuscular synapse in the slow twitch, soleus muscle. These alterations of the endplate region were more obvious in the soleus than in the fast extensor digitorum longus muscle and were slowly reversible, complete recovery requiring about 10 days. Silver-cholinesterase staining and electrophysiological techniques were used to define the spatiotemporal evolution of prejunctional abnormalities. The non-Wallerian-type axonal degeneration of the neuromuscular synapse was characterized by bead or balloon-like varicosities of the focal, distal, and terminal nerve fibers and a retraction of terminal axons. Axonal degeneration was accompanied by junctional and extrajunctional membrane depolarization and was followed by nerve sprouting at focal, distal, and terminal nerve fibers. Transients similar to miniature endplate potentials were recorded along the muscle fiber at distances of 800-2500-mu-m away from the parent endplate. New ectopic endings, originating from the same endplate, were discovered adjacent to the terminal axon and also distant from the parent endplate. Very elaborate terminal arborization and occasional multibranching arose from a progressive growth sprout. The new sprouting may have served to compensate for the loss of synaptic contact caused by sarin. Thus the present study demonstrates a direct cytotoxic effect of sarin and indicates that this organophosphate agent may be an important neurotoxicological tool to understand the mechanisms involved in nerve sprouting. C1 UNIV MARYLAND,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT,655 W BALTIMORE ST,BALTIMORE,MD 21201. USA,MRICD,DIV PATHOPHYSIOL,NEUROTOXICOL BRANCH,ABERDEEN PROVING GROUND,MD 21010. FED UNIV RIO DE JANEIRO,INST BIOPHYS CARLOS CHAGOS FILHO,MOLEC PHARMACOL LAB 2,RIO DE JANEIRO,BRAZIL. NR 34 TC 16 Z9 17 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0887-4476 J9 SYNAPSE JI Synapse PD JUL PY 1991 VL 8 IS 3 BP 218 EP 228 DI 10.1002/syn.890080308 PG 11 WC Neurosciences SC Neurosciences & Neurology GA FR906 UT WOS:A1991FR90600007 PM 1948671 ER PT J AU SCHUBERT, FN AF SCHUBERT, FN TI WHERE EAGLES LAND - PLANNING AND DEVELOPMENT OF UNITED-STATES-ARMY AIRFIELDS, 1910-1941 - BROWN,JE SO TECHNOLOGY AND CULTURE LA English DT Book Review RP SCHUBERT, FN (reprint author), USA,CTR MIL HIST,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0040-165X J9 TECHNOL CULT JI Technol. Cult. PD JUL PY 1991 VL 32 IS 3 BP 631 EP 632 DI 10.2307/3106135 PG 2 WC History & Philosophy Of Science SC History & Philosophy of Science GA HD287 UT WOS:A1991HD28700029 ER PT J AU DAVIS, NL POWELL, N GREENWALD, GF WILLIS, LV JOHNSON, BJB SMITH, JF JOHNSTON, RE AF DAVIS, NL POWELL, N GREENWALD, GF WILLIS, LV JOHNSON, BJB SMITH, JF JOHNSTON, RE TI ATTENUATING MUTATIONS IN THE E2-GLYCOPROTEIN GENE OF VENEZUELAN EQUINE ENCEPHALITIS-VIRUS - CONSTRUCTION OF SINGLE AND MULTIPLE MUTANTS IN A FULL-LENGTH CDNA CLONE SO VIROLOGY LA English DT Article ID CHAIN-TERMINATING INHIBITORS; AGE-DEPENDENT RESISTANCE; TRINIDAD DONKEY STRAIN; SINDBIS VIRUS; STRUCTURAL PROTEINS; CELL-CULTURE; POLIOVIRUS NEUROVIRULENCE; NUCLEOTIDE-SEQUENCE; NEONATAL MICE; GLYCOPROTEIN C1 USA,INFECT DIS RES INST,DIV VET MED,FREDERICK,MD 21701. USA,INFECT DIS RES INST,DIV VIROL,FREDERICK,MD 21701. CTR DIS CONTROL,DIV VECTOR BORNE INFECT DIS,FT COLLINS,CO 80522. RP DAVIS, NL (reprint author), UNIV N CAROLINA,SCH MED,DEPT MICROBIOL & IMMUNOL,CHAPEL HILL,NC 27599, USA. FU NIAID NIH HHS [AI22186]; NINDS NIH HHS [NS26681] NR 32 TC 106 Z9 108 U1 1 U2 3 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0042-6822 J9 VIROLOGY JI Virology PD JUL PY 1991 VL 183 IS 1 BP 20 EP 31 DI 10.1016/0042-6822(91)90114-Q PG 12 WC Virology SC Virology GA FQ368 UT WOS:A1991FQ36800003 PM 2053280 ER PT J AU HOWARD, SL AF HOWARD, SL TI LOW-ENERGY THRESHOLD OF THE FINE-STRUCTURE TRANSITION IN RARE-GAS CHARGE-TRANSFER (RETRACTED ARTICLE. SEE VOL 201, PG 574, 1993) SO CHEMICAL PHYSICS LETTERS LA English DT Article ID CROSSED-BEAM TECHNIQUE AB Data from previous crossed-beam experiments have demonstrated a low-energy threshold of the endoergic fine-structure transition in the charge-transfer reaction of rare gases. Correlation of the spin-orbit energies within this group of the periodic table with the threshold collision energy from these experiments demonstrates that theoretical calculations require three-dimensional analysis instead of one-dimensional at these energies. RP HOWARD, SL (reprint author), USA, BALLIST RES LABS, ABERDEEN PROVING GROUND, MD 21005 USA. NR 9 TC 2 Z9 2 U1 1 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD JUN 28 PY 1991 VL 181 IS 4 BP 298 EP 300 DI 10.1016/0009-2614(91)80074-8 PG 3 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA FW190 UT WOS:A1991FW19000004 ER PT J AU POLONIS, VR ANDERSON, GR VAHEY, MT MORROW, PJ STOLER, D REDFIELD, RR AF POLONIS, VR ANDERSON, GR VAHEY, MT MORROW, PJ STOLER, D REDFIELD, RR TI ANOXIA INDUCES HUMAN-IMMUNODEFICIENCY-VIRUS EXPRESSION IN INFECTED T-CELL LINES SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Note ID TUMOR NECROSIS FACTOR; LONG TERMINAL REPEAT; FACTOR-ALPHA; TYPE-1; INDUCTION; PROTEINS; HIV-1; CLONE; TRANSCRIPTION; REOXYGENATION AB The effects of oxygen deprivation, or anoxia, on human immunodeficiency virus (HIV-1) expression in chronically (ACH.2) and acutely (H9/HIV-1-IIIB) infected cell lines was investigated. Temporary cellular anoxia has previously been shown to activate transcription of endogenous type C leukemia virus sequences, resulting in a significant increase in retroviral RNA within the cell (1). Here we report a 15-fold increase in HIV-1-specific RNA in unstimulated ACH.2 T cells within 24 h of anoxia. This induction of RNA is accompanied by an accumulation of intracellular p24 gag protein as well as an increase in envelope protein. Anoxia induces a further increase in total HIV-1 RNA in ACH.2 cells prestimulated to produce virus by phorbol 12-myristate 13-acetate and in H9 T cells acutely infected with HIV-1-IIIB. The induction of RNA in ACH.2 cells appears to be reversible. Anoxic culture for 24 h followed by a 24-h re-oxygenation period results in a return to "resting state" levels of HIV-1 RNA. These data indicate that oxygen tension within the cellular environment modulates HIV-1 expression, providing a model system in which to study the reversible regulation of HIV-1 RNA and viral gene products within the cell. C1 NEW YORK STATE DEPT HLTH,ROSWELL PK MEM INST,DEPT CELL & MOLEC BIOL,BUFFALO,NY 14263. RP POLONIS, VR (reprint author), WALTER REED ARMY MED CTR,DEPT RETROVIRAL RES,13 TAFT CT,SUITE 201,ROCKVILLE,MD 20850, USA. FU NCI NIH HHS [CA48828] NR 37 TC 18 Z9 18 U1 0 U2 0 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD JUN 25 PY 1991 VL 266 IS 18 BP 11421 EP 11424 PG 4 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA FT762 UT WOS:A1991FT76200005 PM 1904863 ER PT J AU ALVING, CR AF ALVING, CR TI LIPOSOMES AS CARRIERS OF ANTIGENS AND ADJUVANTS SO JOURNAL OF IMMUNOLOGICAL METHODS LA English DT Review DE VACCINE; ADJUVANT; LIPOSOME ID MALARIA SPOROZOITE ANTIGEN; MURAMYL TRIPEPTIDE PHOSPHATIDYLETHANOLAMINE; BACTERIAL PEPTIDOGLYCAN DERIVATIVES; HERPES-SIMPLEX VIRUS; CLASS-II MHC; LIPID-A; IMMUNE-RESPONSE; IMMUNOLOGICAL ADJUVANTS; CHOLERA-TOXIN; LYMPHOCYTES-T AB Liposomes have been widely used as carriers of protein or peptide antigens. Antigenic materials can be attached to the outer surface, encapsulated within the internal aqueous spaces, or reconstituted within the lipid bilayers of the liposomes. The natural tendency of liposomes to interact with macrophages has served as the primary rationale for utilizing liposomes as carriers of antigens. Liposomes also serve as carriers of a variety of adjuvants and mediators, including lipid A, muramyl dipeptide and its derivatives, interleukin-1, and interleukin-2. Research utilizing in vitro cell culture models has demonstrated that liposomes containing both appropriate antigens and major histocompatibility gene complex molecules can induce antigen-specific genetically restricted cytotoxic T lymphocytes. Liposomes induce immune reactions through classical interactions with antigen presenting cells. However, modelling experiments have also demonstrated that liposomes can even substitute for antigen presenting cells, and cell-free genetically restricted and nonrestricted presentation of antigens by liposomes to helper T lymphocytes has been demonstrated. Liposomes are successful for inducing potent immunity in vivo and they are now being employed in numerous immunization procedures and as vehicles for candidate vaccines. RP ALVING, CR (reprint author), WALTER REED ARMY MED CTR, DEPT MEMBRANE BIOCHEM, WASHINGTON, DC 20307 USA. NR 101 TC 269 Z9 270 U1 2 U2 21 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1759 EI 1872-7905 J9 J IMMUNOL METHODS JI J. Immunol. Methods PD JUN 24 PY 1991 VL 140 IS 1 BP 1 EP 13 DI 10.1016/0022-1759(91)90120-5 PG 13 WC Biochemical Research Methods; Immunology SC Biochemistry & Molecular Biology; Immunology GA FT829 UT WOS:A1991FT82900001 PM 1712030 ER PT J AU JAMES, WF BARKO, JW TAYLOR, WD AF JAMES, WF BARKO, JW TAYLOR, WD TI EFFECTS OF ALUM TREATMENT ON PHOSPHORUS DYNAMICS IN A NORTH-TEMPERATE RESERVOIR SO HYDROBIOLOGIA LA English DT Article DE ALUMINUM SULFATE; EXTERNAL P-LOADING; INTERNAL P-LOADING; PHOSPHORUS; CHLOROPHYLL; RESERVOIRS ID EPILIMNETIC PHOSPHORUS; LITTORAL SEDIMENTS; NUTRIENT TRANSPORT; EDDY DIFFUSION; ONONDAGA LAKE; SHAGAWA LAKE; WASHINGTON; WISCONSIN; MIGRATION; MINNESOTA AB Eau Galle Reservoir, Wisconsin, was treated with a hypolimnetic dose of aluminum sulfate (alum) in 1986 to diminsh excessive phytoplankton production associated with high phosphorus loading from anoxic, profundal sediments. Prior to treatment, internal total phosphorus (TP) loading was 3 to 6 times greater than external TP loading during summer stratification. Periodic increases in epilimnetic TP mass and chlorophyll a concentrations closely corresponded with elevated internal TP loading. For one year following treatment, internal TP loading and concentrations of soluble reactive phosphorus (SRP) in the hypolimnion were substantially reduced. However, abnormally high external TP loading during the stratified period of 1986 resulted in high TP mass and chlorophyll a in the epilimnion. During the summers of 1987 and 1988, effects of alum treatment on internal TP loading were essentially negated, and epilimnetic TP mass and chlorophyll a remained unchanged from pretreatment years. Multiple potential sources of P input to this reservoir make it difficult to reduce epilimnetic P and phytoplankton growth. RP JAMES, WF (reprint author), WATERWAYS EXPT STN,ENVIRONM LAB,VICKSBURG,MS 39180, USA. NR 51 TC 16 Z9 16 U1 2 U2 5 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0018-8158 J9 HYDROBIOLOGIA JI Hydrobiologia PD JUN 21 PY 1991 VL 215 IS 3 BP 231 EP 241 DI 10.1007/BF00764858 PG 11 WC Marine & Freshwater Biology SC Marine & Freshwater Biology GA FY909 UT WOS:A1991FY90900006 ER PT J AU HERRMANN, JE TAYLOR, DN ECHEVERRIA, P BLACKLOW, NR AF HERRMANN, JE TAYLOR, DN ECHEVERRIA, P BLACKLOW, NR TI ASTROVIRUSES AS A CAUSE OF GASTROENTERITIS IN CHILDREN SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID MONOCLONAL-ANTIBODIES; ANTIGEN-DETECTION; SEROTYPES; DIAGNOSIS; VIRUSES AB Background. Infection with astroviruses has been associated with gastroenteritis in children, and serologic surveys indicate that this infection may be frequent. The importance of astroviruses as agents of gastroenteritis has not been shown in a controlled study, however. Methods. We used monoclonal antibody-based enzyme immunoassays to detect astroviruses, enteric adenoviruses, and rotaviruses in stool samples obtained from age-matched children with and children without gastroenteritis. The samples were obtained in two studies, three years apart, among patients attending an outpatient clinic in Bangkok, Thailand. Results. In the first study, astroviruses were detected in 8.6 percent (96 of 1111) of the children with gastroenteritis and in 2.0 percent (19 of 947) of the children without gastroenteritis. In the second study the rates were 8.6 percent (50 of 580) and 2.1 percent (11 of 512), respectively. For both studies combined, enteric adenoviruses were detected in 2.6 percent of those with gastroenteritis and in 0.5 percent of the controls, whereas rotaviruses were detected in 19 percent of those with gastroenteritis and in 1.0 percent of the controls. The clinical findings associated with astrovirus infection were similar to those associated with rotavirus infection, except for a trend toward greater dehydration in the children infected with rotaviruses. Conclusions. These two controlled studies involving a total of 3150 Thai children provide evidence that astroviruses are a common cause of viral gastroenteritis. Astroviruses were found in association with gastroenteritis more frequently than were enteric adenoviruses, and with nearly half the frequency of rotaviruses. C1 ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. RP HERRMANN, JE (reprint author), UNIV MASSACHUSETTS,SCH MED,DIV INFECT DIS & IMMUNOL,WORCESTER,MA 01655, USA. NR 26 TC 139 Z9 144 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD JUN 20 PY 1991 VL 324 IS 25 BP 1757 EP 1760 DI 10.1056/NEJM199106203242501 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA FR681 UT WOS:A1991FR68100001 PM 1645459 ER PT J AU KIM, A ZETO, R YOUMANS, R CONRAD, J KONDEK, C WEINER, M BRISKER, H AGEE, J JASPER, L LALEVIC, B AF KIM, A ZETO, R YOUMANS, R CONRAD, J KONDEK, C WEINER, M BRISKER, H AGEE, J JASPER, L LALEVIC, B TI MONOLITHIC, PHOTOCONDUCTIVE IMPULSE GENERATOR USING A GAAS WAFER SO APPLIED PHYSICS LETTERS LA English DT Article AB A new technique for generating multikilovolt, nanosecond pulses was demonstrated. The technique relies on the use of a semi-insulating GaAs substrate, which performs the dual functions of energy storage and switching. The energy storage was realized by fabricating disk-shaped electrodes on a 7.5-cm-diameter GaAs wafer, thereby forming a radial transmission line. A mode-locked Nd:YAG laser was used to activate the switch, which is vertically fabricated in the central region of the substrate. This device generated and delivered about a 2 MW pulse with a rise time of less than 500 ps to a 50-OMEGA-load. C1 LABCOM,HARRY DIAMOND LABS,ADELPHI,MD 20783. RUTGERS STATE UNIV,DEPT ELECT & COMP ENGN,PISCATAWAY,NJ 08854. RP KIM, A (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,LABCOM,FT MONMOUTH,NJ 07703, USA. NR 5 TC 0 Z9 0 U1 1 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUN 17 PY 1991 VL 58 IS 24 BP 2812 EP 2814 DI 10.1063/1.104744 PG 3 WC Physics, Applied SC Physics GA FR444 UT WOS:A1991FR44400030 ER PT J AU KARLE, JM KARLE, IL AF KARLE, JM KARLE, IL TI STRUCTURE OF THE RADIATION PROTECTION AGENT S-2-(5-AMINOPENTYLAMINO) ETHYLPHOSPHOROTHIOIC ACID (WR 2823) DIHYDRATE SO ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS LA English DT Article ID WR-2721; CRYSTAL; WR-1065 AB C7H19N2O3PS.2H2O, M(r) = 278.3, triclinic, P1BAR, a = 6.314 (2), b = 9.616 (2), c = 12.277 (7) angstrom, alpha = 84.73 (4), beta = 75.69 (4), gamma = 73.73 (3)-degrees, V = 693.1 angstrom3, Z = 2, D(x) = 1.333 g cm-3, Cu K-alpha, lambda = 1.54178 angstrom, mu = 32.6 cm-1, F(000) = 300, room temperature, final R = 6.5% for 1904 reflections with \F-omicron\ > 3-sigma (F). WR 2823 crystallized as a double zwitterion with the two phosphate H atoms residing on the two N atoms. An intramolecular hydrogen bond between O(1) and N(3) causes the molecule to bend at the phosphate end. The S-P bond length is 2.126 (1) angstrom, and the three P-O bonds are of nearly equal length at 1.50 (1) angstrom. The WR 2823 molecules pack head to tail with hydrogen bonds between neighboring amine and phosphate groups and to water molecules. C1 USN,RES LAB,STRUCT MATTER LAB,WASHINGTON,DC 20375. RP KARLE, JM (reprint author), WALTER REED ARMY MED CTR,DEPT PHARMACOL,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 18 TC 2 Z9 2 U1 0 U2 0 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0108-2701 J9 ACTA CRYSTALLOGR C JI Acta Crystallogr. Sect. C-Cryst. Struct. Commun. PD JUN 15 PY 1991 VL 47 BP 1242 EP 1245 DI 10.1107/S0108270190010745 PN 6 PG 4 WC Chemistry, Multidisciplinary; Crystallography SC Chemistry; Crystallography GA FU704 UT WOS:A1991FU70400040 ER PT J AU BURLING, FT GABRIELSEN, B GOLDSTEIN, BM AF BURLING, FT GABRIELSEN, B GOLDSTEIN, BM TI STRUCTURES OF THE 2',3'-DIDEOXY AND 2',3'-DIDEHYDRO-2',3'-DIDEOXY ANALOGS OF TIAZOFURIN SO ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS LA English DT Article AB 2',3'-Dideoxytiazofurin [2-(2',3'-dideoxy-beta-D-glycero-pentafuranosyl)thiazole-4-carboxamide] hemihydrate (1), C9H12N2O3S.1/2H2O, M(r) = 237.3, monoclinic, C2 a = 23.141 (2), b = 5.912 (1), c = 8.252 (1) angstrom, beta = 90.71 (1)-degrees, V = 1128.9 (4) angstrom 3, Z = 4, D(x) = 1.396 g cm-3, Cu K-alpha, lambda = 1.54178 angstrom, mu = 25.0 cm-1, F(000) = 500, T = 295 K, R = 0.0319 for all 1316 unique reflections. 2',3'-Didehydro-2',3'-dideoxytiazofurin [2-(2',3'-dideoxy-beta-D-glycero-pent-2-enofuranosyl)thiazole-4-carboxamide] (2), C9H10N2O3S, M(r) = 226.3, orthorhombic, P2(1)2(1)2(1), a = 22.172 (2), b = 8.019 (1), c = 5.991 (1) angstrom, V = 1065.2 (4) angstrom 3, Z = 4, D(x) = 1.411 g cm-3, Cu K-alpha, lambda = 1.54178 angstrom, mu = 25.9 cm-1, F(000) = 472, T = 295 K, R = 0.0344 for all 957 unique reflections. Both structures show a close contact between the thiazole S and the pentose O(1') atoms. S...O(1') distances are 2.834 (2) angstrom in (1) and 2.835 (1) angstrom in (2), resulting from C-glycosidic torsion angeles of 14.1 (2) and 5.2 (3)-degrees respectively. This unusual feature is conserved in the crystal structures of other thiazole nucleosides [Goldstein, Mao & Marquez (1988). J. Med. Chem. 31, 1026-1031]. C1 UNIV ROCHESTER,MED CTR,DEPT BIOPHYS,ROCHESTER,NY 14642. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. FU NCI NIH HHS [CA-45145] NR 17 TC 12 Z9 12 U1 0 U2 0 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0108-2701 J9 ACTA CRYSTALLOGR C JI Acta Crystallogr. Sect. C-Cryst. Struct. Commun. PD JUN 15 PY 1991 VL 47 BP 1272 EP 1275 DI 10.1107/S0108270190011714 PN 6 PG 4 WC Chemistry, Multidisciplinary; Crystallography SC Chemistry; Crystallography GA FU704 UT WOS:A1991FU70400051 PM 1953981 ER PT J AU ARDAY, DR BRUNDAGE, JF GARDNER, LI GOLDENBAUM, M WANN, F WRIGHT, S AF ARDAY, DR BRUNDAGE, JF GARDNER, LI GOLDENBAUM, M WANN, F WRIGHT, S TI THE EFFECT OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ANTIBODY STATUS ON MILITARY APPLICANT APTITUDE-TEST SCORES SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Article DE AIDS DEMENTIA COMPLEX; HIV SEROPOSITIVITY; HIV-1; MILITARY PERSONNEL; NEUROPSYCHOLOGICAL TESTS; NEUROPSYCHOLOGY ID AIDS DEMENTIA COMPLEX; NEUROLOGICAL COMPLICATIONS; CEREBROSPINAL-FLUID; INFECTION; INDIVIDUALS; FEATURES; BRAIN AB The authors conducted a population-based study to attempt to estimate the effect of human immunodeficiency virus type 1 (HIV-1) seropositivity on Armed Services Vocational Aptitude Battery test scores in otherwise healthy individuals with early HIV-1 infection. The Armed Services Vocational Aptitude Battery is a 10-test written multiple aptitude battery administered to all civilian applicants for military enlistment prior to serologic screening for HIV-1 antibodies. A total of 975,489 induction testing records containing both Armed Services Vocational Aptitude Battery and HIV-1 results from October 1985 through March 1987 were examined. An analysis data set (n = 7,698) was constructed by choosing five controls for each of the 1,283 HIV-1-positive cases, matched on five-digit ZIP code, and a multiple linear regression analysis was performed to control for demographic and other factors that might influence test scores. Years of education was the strongest predictor of test scores, raising an applicant's score on a composite test nearly 0.16 standard deviation per year. The HIV-1-positive effect on the composite score was -0.09 standard deviation (99% confidence interval -0.17 to -0.02). Separate regressions on each component test within the battery showed HIV-1 effects between -0.39 and +0.06 standard deviation. The two Armed Services Vocational Aptitude Battery component tests felt a priori to be the most sensitive to HIV-1-positive status showed the least decrease with seropositivity. Much of the variability in test scores was not predicted by either HIV-1 serostatus or the demographic and other factors included in the model. There appeared to be little evidence of a strong HIV-1 effect. C1 WALTER REED ARMY MED CTR,DEPT EPIDEMIOL,DIV PREVENT MED,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT ADV PREVENT MED STUDIES,DIV PREVENT MED,WASHINGTON,DC 20307. US MIL ENTRANCE PROC COMMAND,N CHICAGO,IL. NR 24 TC 4 Z9 4 U1 1 U2 1 PU AMER J EPIDEMIOLOGY PI BALTIMORE PA 624 N BROADWAY RM 225, BALTIMORE, MD 21205 SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 15 PY 1991 VL 133 IS 12 BP 1210 EP 1219 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA FV266 UT WOS:A1991FV26600002 PM 2063829 ER PT J AU KIANG, JG WU, YY LIN, MC AF KIANG, JG WU, YY LIN, MC TI HEAT-TREATMENT INDUCES AN INCREASE IN INTRACELLULAR CYCLIC-AMP CONTENT IN HUMAN EPIDERMOID-A-431 CELLS SO BIOCHEMICAL JOURNAL LA English DT Article ID INHIBITS NA+/H+ EXCHANGE; NEURO-BLASTOMA CELLS; A-431 CELLS; VITAMIN-E; RAT; HYPERTHERMIA; ADENOSINE; ACCUMULATION; MEMBRANE; CAMP AB The basal level of intracellular cyclic AMP (cAMP(i)) in A-431 cells incubated at 37-degrees-C in Na+-containing Hanks solution is 2086 +/- 139 fmol/10(6) cells. When cells are exposed to 45-degrees-C for 10 min, cAMP(i) increases by 40 +/- 4%, and then returns to basal levels within 30 min. Incubating cells in Ca2+-free or Mg2+-free Hanks solution has no effect on the heat-induced increase in cAMP(i), but the increase is inhibited by acid-loading cells to intracellular pH 7.0 or 6.8. In unheated cells, cAMP(i) increases by 16 +/- 8%, 53 +/- 7%, or 39 +/- 8% when incubated with 3-isobutyl-1-methylxanthine (1 mM), Ro 20-1724 (0.5 mM), or theophylline (1 mM) respectively. However, heat treatment further elevates cAMP(i) in cells treated with phosphodiesterase inhibitors, indicating that heat treatment and phosphodiesterase inhibitors elevate cAMP(i) by a different pathway(s). Heat treatment increases adenylate cyclase activity 2.5-fold. When forskolin (150-mu-M), an adenylate cyclase stimulator, is applied to cells, the basal cAMP(i) increases 28 +/- 6-fold compared with controls. Subsequent heating of these cells lowers cAMP(i) levels to 7.0 +/- 0.5 times that in control cells. This decrease is prevented by pretreatment with pertussis toxin (30 ng/ml, 24 h), suggesting that G-proteins are involved in the process of heat-induced cAMP(i) increase. 2-Deoxy-D-glucose (10 mM), NaN3 (10 mM) and 2,4-dinitrophenol (1 mM) also increase cAMP(i) in A-431 cells. However, application of these metabolic inhibitors to cells before heat treatment does not result in cAMP(i) levels greater than that observed in cells with heat alone. Similar observations are obtained in heat-treated cells previously exposed to adenosine, but not to AMP or ADP. These data are the first to suggest that thermally induced increase in cAMP(i) is due to a combination of activation of adenylate cyclase and G-proteins, and an increase in adenosine owing to ATP breakdown caused by hyperthermia. C1 NIH,CELLULAR & DEV BIOL LAB,BETHESDA,MD 20892. RP KIANG, JG (reprint author), WALTER REED ARMY MED CTR,DEPT CLIN PHYSIOL,WASHINGTON,DC 20307, USA. NR 42 TC 30 Z9 31 U1 0 U2 0 PU PORTLAND PRESS PI LONDON PA 59 PORTLAND PLACE, LONDON, ENGLAND W1N 3AJ SN 0264-6021 J9 BIOCHEM J JI Biochem. J. PD JUN 15 PY 1991 VL 276 BP 683 EP 689 PN 3 PG 7 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA FU093 UT WOS:A1991FU09300017 PM 1648349 ER PT J AU RICHARDS, F PERRY, DJ GOUTSOU, M MODEAS, C MUCHMORE, E REGE, V CHAHINIAN, AP HIRSH, V POIESZ, B GREEN, MR AF RICHARDS, F PERRY, DJ GOUTSOU, M MODEAS, C MUCHMORE, E REGE, V CHAHINIAN, AP HIRSH, V POIESZ, B GREEN, MR TI CHEMOTHERAPY WITH 5-FLUOROURACIL (5-FU) AND CISPLATIN OR 5-FU, CISPLATIN, AND VINBLASTINE FOR ADVANCED NON-SMALL-CELL LUNG-CANCER - A RANDOMIZED PHASE-II STUDY OF THE CANCER AND LEUKEMIA GROUP-B SO CANCER LA English DT Article ID DIVIDED-DOSE VINBLASTINE; COMBINATION CHEMOTHERAPY; STAGE-III; CARCINOMA; INFUSION AB Two hundred forty-seven patients with previously untreated nonresectable non-small cell lung cancer (NSCLC) were entered in a prospective, randomized Phase II trial. Response assessment was possible in 232 patients, and 237 patients were evaluable for survival. Thirteen partial responses (11%) and 5 regressions (4%) of evaluable disease were obtained for the 116 patients treated with 5-fluorouracil (5-FU) and cisplatin (C) (95% confidence interval [CI], 8.5% to 21.5%). The median time to progression was 2.2 months and the median survival time was 4.6 months for 5-FU plus C. Twenty-three partial responses (20%) and 4 regressions (3%) of evaluable disease were obtained for the 116 patients treated with 5-FU, C, and vinblastine (V) (95% CI, 15.3% to 30.7%). The median time to progression was 2.8 months and the median survival time was 5.6 months for 5-FU, C, and V. The 5-FU and C doses were equivalent in the two treatment regimens. Sixteen of 85 patients (19%) with a performance status of 0 and 18 of 103 patients (17%) with a performance status of 1 responded, whereas only 2 of 44 patients (5%) with a performance status of 2 or greater responded (P = 0.009). Patients who had received locoregional radiation therapy had a lower overall response rate then those in the no prior radiation therapy group (P = 0.028). The median survival time for patients with a performance status of 0 or 1 was 6.3 months compared with 1.9 months for patients with a performance status of 2 or greater (P < 0.001). Performance status also appeared to be a significant factor for time to progression. More frequent and severe leukopenia, fever, genitourinary (GU) toxicity, and pulmonary toxicity was reported with 5-FU, C, and V. There were three treatment-related deaths with 5-FU, C, and V and one treatment-related death with 5-FU plus C. Grade III/VI myelotoxicity was not influenced by prior radiation therapy or performance status. Neither regimen is active enough to be considered as standard therapy for advanced NSCLC. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. HARVARD UNIV,SCH PUBL HLTH,BOSTON,MA 02115. FRONTIER SCI & TECHNOL RES FDN INC,AMHERST,NY. UNIV CALIF SAN DIEGO,CTR CANC,LA JOLLA,CA 92093. UNIV CALIF SAN DIEGO,DEPT MED,LA JOLLA,CA 92093. RHODE ISL HOSP,PROVIDENCE,RI 02902. MT SINAI MED CTR,NEW YORK,NY 10029. MCGILL UNIV,CTR CANC,MONTREAL H3A 2T5,QUEBEC,CANADA. SUNY UPSTATE MED CTR,SYRACUSE,NY 13210. RP RICHARDS, F (reprint author), WAKE FOREST UNIV,BOWMAN GRAY SCH MED,CTR CANC,300 S HAWTHORNE RD,WINSTON SALEM,NC 27103, USA. NR 20 TC 23 Z9 23 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD JUN 15 PY 1991 VL 67 IS 12 BP 2974 EP 2979 PG 6 WC Oncology SC Oncology GA FR254 UT WOS:A1991FR25400005 PM 1646066 ER PT J AU GRUBER, JB HILLS, ME SELTZER, MD STEVENS, SB MORRISON, CA TURNER, GA KOKTA, MR AF GRUBER, JB HILLS, ME SELTZER, MD STEVENS, SB MORRISON, CA TURNER, GA KOKTA, MR TI ENERGY-LEVELS AND CRYSTAL QUANTUM STATES OF TRIVALENT HOLMIUM IN YTTRIUM-ALUMINUM-GARNET SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID ELECTRONIC RAMAN-SPECTRA; FIELD PARAMETERS; DIODE-LASER; LANTHANIDE IONS; SPECTROSCOPY; ABSORPTION; EMISSION; Y3AL5O12; ND-3+; HO3+ AB Absorption spectra of Ho3+ ions in yttrium aluminum garnet (Ho3+:YAG) are reported between 2.16 and 0.23-mu-m at various temperatures between 4 K and room temperature. Laser-excited excitation spectra and emission spectra from the 5F4 and 5S2 multiplet manifolds to the ground state manifold 5I8 were obtained at 4, 20, and 55 K. The majority of Ho3+ ions substitute for Y3+ ions in sites of D2 point-group symmetry in the lattice. Over 1000 temperature-dependent transitions (hot bands) establish 280 experimental Stark levels of the 4 f10(2S+1L(J)) multiplet manifolds. Symmetry labels GAMMA-1, GAMMA-2, GAMMA-3, or GAMMA-4, appropriate to D2 symmetry, have been assigned to Stark levels up to 43 000 cm-1. Experimental levels are compared with results obtained from a theoretical calculation. The model Hamiltonian includes Coulombic, spin-orbit, and interconfiguration interaction terms for the 4 f10 atomic configuration of Ho3+ and crystal-field terms in D2 symmetry. The Hamiltonian was diagonalized within the 50 lowest 2S+1L(J) manifolds in a LSJM(J) basis set that includes 486 calculated levels. Comparison between 151 experimental Stark levels and the corresponding levels of the lowest 199 calculated levels yields an rms deviation of 4.3 cm-1. C1 USN,CTR WEAP,RES DEPT,DIV CHEM,CHINA LAKE,CA 93555. USA,LAB COMMAND,HARRY DIAMOND LABS,ADELPHI,MD 20783. UNION CARBIDE CORP,DIV ELECTR,MAT GRP,WASHOUGAL,WA 98671. RP GRUBER, JB (reprint author), SAN JOSE STATE UNIV,DEPT PHYS,SAN JOSE,CA 95192, USA. NR 59 TC 44 Z9 45 U1 5 U2 13 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JUN 15 PY 1991 VL 69 IS 12 BP 8183 EP 8204 DI 10.1063/1.347422 PG 22 WC Physics, Applied SC Physics GA FU812 UT WOS:A1991FU81200035 ER PT J AU YOURICK, DL LAPLACA, MC MEYERHOFF, JL AF YOURICK, DL LAPLACA, MC MEYERHOFF, JL TI NOREPINEPHRINE-STIMULATED PHOSPHATIDYLINOSITOL METABOLISM IN GENETICALLY EPILEPSY-PRONE AND KINDLED RATS SO BRAIN RESEARCH LA English DT Note DE INOSITOL PHOSPHATE; NORADRENALINE; CEREBRAL CORTEX; AMYGDALA/PYRIFORM CORTEX; HIPPOCAMPUS; KINDLING; EPILEPSY; RAT ID CENTRAL NERVOUS-SYSTEM; SEIZURE PREDISPOSITION; CEREBRAL-CORTEX; PHOSPHOINOSITIDE HYDROLYSIS; NEUROBIOLOGY; RECEPTORS; BRAIN; ABNORMALITIES; TURNOVER AB Genetically epilepsy-prone rats (GEPR-9) and kindled rats have reduced noradrenergic function. In the present study, norepinephrine-stimulated accumulation of inositol phosphates was reduced in cerebral cortex of GEPR-9 and kindled rats when compared to control and non-kindled rats, respectively. No such reduction was found in amygdala/pyriform cortex and hippocampus. These results support the hypothesis that cortical noradrenergic and associated second messenger systems are impaired in epilepsy. RP YOURICK, DL (reprint author), WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307, USA. NR 28 TC 17 Z9 17 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0006-8993 J9 BRAIN RES JI Brain Res. PD JUN 14 PY 1991 VL 551 IS 1-2 BP 315 EP 318 DI 10.1016/0006-8993(91)90948-U PG 4 WC Neurosciences SC Neurosciences & Neurology GA FV304 UT WOS:A1991FV30400044 PM 1913159 ER EF