FN Thomson Reuters Web of Science™ VR 1.0 PT J AU VANCAUWENBERGHE, O HELLMAN, OC HERBOTS, H TAN, WJ OLSON, JL CROFT, WJ AF VANCAUWENBERGHE, O HELLMAN, OC HERBOTS, H TAN, WJ OLSON, JL CROFT, WJ TI COMPARATIVE-STUDY OF LOW-ENERGY ION-BEAM OXIDATION OF SI(100), GE/SI(100) AND SI1-XGEX/SI(100) SO MATERIALS SCIENCE AND ENGINEERING B-SOLID STATE MATERIALS FOR ADVANCED TECHNOLOGY LA English DT Article; Proceedings Paper CT SYMP AT THE 1991 SPRING MEETING OF THE EUROPEAN MATERIALS RESEARCH SOC : ION BEAM SYNTHESIS OF COMPOUND AND ELEMENTAL LAYERS CY MAY 28-31, 1991 CL STRASBOURG, FRANCE SP EUROPEAN MAT RES SOC ID SILICON; KINETICS AB Low energy ion beam oxidation (IBO) of Si(100) and germanium and Si1-xGex grown by molecular beam epitaxy on Si(100) was investigated at room temperature using O-18(2)+ ion beams with energies E(ion) ranging from 100 eV to 1 keV. The dependence of phase formation and film properties upon ion energy was established. In the case of silicon, thin films of stoichiometric SiO2 are formed at each energy studied and their thickness increases from 39 to 70 A with increasing E(ion). Insulating GeO2 can only be formed for E(ion) less-than-or-equal-to 200 eV. Under IBO, both silicon and germanium in Si0.8Ge0.2 are fully oxidized. At each energy investigated, thin SiGe dioxide films are formed and found to be insulating by scanning electron microscopy. This contrasts with IBO of elemental germanium and shows that the presence of silicon surrounding the germanium in the SiGe alloy enhances the oxidation of germanium under IBO. C1 USA,MAT TECHNOL LAB,WATERTOWN,MA 02172. RP VANCAUWENBERGHE, O (reprint author), MIT,CAMBRIDGE,MA 02139, USA. NR 11 TC 10 Z9 10 U1 0 U2 0 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0921-5107 J9 MAT SCI ENG B-SOLID JI Mater. Sci. Eng. B-Solid State Mater. Adv. Technol. PD JAN 20 PY 1992 VL 12 IS 1-2 BP 97 EP 101 DI 10.1016/0921-5107(92)90266-C PG 5 WC Materials Science, Multidisciplinary; Physics, Condensed Matter SC Materials Science; Physics GA HE158 UT WOS:A1992HE15800019 ER PT J AU WILLIAMS, W DRABICK, JJ TANG, DB AF WILLIAMS, W DRABICK, JJ TANG, DB TI CD4 COUNTS AND HIV-RELATED DEATHS SO ANNALS OF INTERNAL MEDICINE LA English DT Letter C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP WILLIAMS, W (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 3 TC 4 Z9 4 U1 0 U2 0 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD JAN 15 PY 1992 VL 116 IS 2 BP 168 EP 168 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA GZ356 UT WOS:A1992GZ35600013 PM 1345773 ER PT J AU GENDELMAN, HE BACA, LM KUBRAK, CA GENIS, P BURROUS, S FRIEDMAN, RM JACOBS, D MELTZER, MS AF GENDELMAN, HE BACA, LM KUBRAK, CA GENIS, P BURROUS, S FRIEDMAN, RM JACOBS, D MELTZER, MS TI INDUCTION OF IFN-ALPHA IN PERIPHERAL-BLOOD MONONUCLEAR-CELLS BY HIV-INFECTED MONOCYTES - RESTRICTED ANTIVIRAL ACTIVITY OF THE HIV-INDUCED IFN SO JOURNAL OF IMMUNOLOGY LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; HERPES-SIMPLEX VIRUS; INTERFERON-ALPHA; KAPOSI-SARCOMA; SYNDROME AIDS; REPLICATION; MACROPHAGES; LYMPHOCYTES; BETA; LEUKOCYTES AB PBMC cocultured with HIV-infected monocytes for 12 to 48 h released high levels of IFN activity. IFN titers were directly dependent upon time after virus infection and level of HIV replication in infected cells. IFN induction in PBMC was evident with HIV-infected monocytes and PBMC and with myeloid and lymphoblastoid cell lines with at least three different HIV strains. In HIV-infected cell line pairs in which virus infection occurs in both productive and restricted forms, IFN induction in PBMC occurred only with productive infection. IFN activity was acid stable and completely neutralized by antibodies against IFN-alpha. Induction of IFN required cell-cell contact between HIV-infected cells and PBMC, but was independent of MHC compatibility. With PBMC cocultured with autologous HIV-infected monocytes, IFN induction was highly selective: IL-1-beta, IL-6, or TNF-alpha activity and mRNA were not detected. Cell surface determinants on HIV-infected monocytes that induced IFN in PBMC remained active after fixation in 4% paraformaldehye. Both adherent and nonadherent PBMC produced IFN after coculture with HIV-infected monocytes. Ability to produce IFN by PBMC was not affected by depletion of T cell, NK cell, B cell, or monocyte subpopulations. The IFN activity produced by PBMC cocultured with HIVinfected cells was about 20-fold less active than equal quantities of rIFN-alpha(2b) for inhibition of HIV replication in monocytes and at low concentrations enhanced virus growth. Clinical studies with HIV-infected patients and parallel findings in animal lentivirus disease suggest an adverse role for IFN in disease progression. Conditions for induction of IFN in the culture system described in this report may mimic those in the HIV-infected patient. Defining the molecular basis for IFN induction, the cells that produce IFN, and the altered biologic activity of this important cytokine may provide insight into the pathogenesis of HIV disease. C1 HENRY M JACKSON FDN,ADV MIL MED,ROCKVILLE,MD 20852. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. VIRAGEN INC,HIALEAH,FL 33016. RP GENDELMAN, HE (reprint author), WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307, USA. NR 54 TC 56 Z9 56 U1 0 U2 2 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD JAN 15 PY 1992 VL 148 IS 2 BP 422 EP 429 PG 8 WC Immunology SC Immunology GA GZ965 UT WOS:A1992GZ96500017 PM 1729362 ER PT J AU ATHALE, RA MAIT, JN PRATHER, DW AF ATHALE, RA MAIT, JN PRATHER, DW TI OPTICAL MORPHOLOGICAL IMAGE-PROCESSING WITH ACOUSTOOPTIC DEVICES SO OPTICS COMMUNICATIONS LA English DT Article AB An optical morphological image processor is described and demonstrated in which structuring elements are generated using an acoustooptic device in the Fourier plane of a coherent optical correlator. The size and shape of the structuring element can be modified easily and rapidly by changing the drive signal to the acoustooptic device. Space-bandwidth limitations on the system due to the use of an acoustooptic device are discussed and results of erosion and dilation experiments are presented. C1 USA,HARRY DIAMOND LABS,ADELPHI,MD 20783. RP ATHALE, RA (reprint author), GEORGE MASON UNIV,DEPT ELECT & COMP ENGN,FAIRFAX,VA 22030, USA. NR 9 TC 9 Z9 9 U1 2 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0030-4018 J9 OPT COMMUN JI Opt. Commun. PD JAN 15 PY 1992 VL 87 IS 3 BP 99 EP 104 DI 10.1016/0030-4018(92)90387-7 PG 6 WC Optics SC Optics GA HB698 UT WOS:A1992HB69800005 ER PT J AU BAHDER, TB AF BAHDER, TB TI ANALYTIC DISPERSION-RELATIONS NEAR THE GAMMA-POINT IN STRAINED ZINCBLENDE CRYSTALS SO PHYSICAL REVIEW B LA English DT Article ID QUANTUM RESONANCES; VALENCE BANDS AB An eight-band k.p model of the electronic states near the GAMMA point of a strained zinc-blende semiconductor is renormalized using Lowdin perturbation theory. The renormalization leads to matrices of reduced dimensionality, 2x2, 4x4, and 2x2, for the conduction, light- and heavy-hole, and spin-orbit split-off bands, respectively. The reduced dimensionality of these matrices allows us to obtain analytic dispersion relations in the presence of small but arbitrary strains. Comparison of the analytic dispersion relations is made to those obtained by numerically diagonalizing the eight-band model for the case of biaxially strained and unstrained GaAs. RP BAHDER, TB (reprint author), USA,LAB COMMAND,HARRY DIAMOND LABS,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. NR 19 TC 38 Z9 38 U1 1 U2 6 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD JAN 15 PY 1992 VL 45 IS 4 BP 1629 EP 1637 DI 10.1103/PhysRevB.45.1629 PG 9 WC Physics, Condensed Matter SC Physics GA HB929 UT WOS:A1992HB92900012 ER PT J AU GREGORY, DA KIRSCH, JC TAM, EC AF GREGORY, DA KIRSCH, JC TAM, EC TI FULL COMPLEX MODULATION USING LIQUID-CRYSTAL TELEVISIONS SO APPLIED OPTICS LA English DT Note AB An optical architecture is proposed that uses two modified liquid-crystal televisions (LCTV's) to control amplitude and phase modulation independently. Two applications in pattern recognition are discussed. C1 UNIV N CAROLINA,CHAPEL HILL,NC 27514. RP GREGORY, DA (reprint author), USA,MISSILE COMMAND,REDSTONE ARSENAL,AL 35898, USA. NR 5 TC 65 Z9 65 U1 0 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD JAN 10 PY 1992 VL 31 IS 2 BP 163 EP 165 PG 3 WC Optics SC Optics GA HA864 UT WOS:A1992HA86400002 PM 20717387 ER PT J AU OCKENHOUSE, CF BETAGERI, R SPRINGER, TA STAUNTON, DE AF OCKENHOUSE, CF BETAGERI, R SPRINGER, TA STAUNTON, DE TI PLASMODIUM FALCIPARUM-INFECTED ERYTHROCYTES BIND ICAM-1 AT A SITE DISTINCT FROM LFA-1, MAC-1, AND HUMAN RHINOVIRUS SO CELL LA English DT Article ID INTERCELLULAR-ADHESION MOLECULE-1; MEMBRANE GLYCOPROTEIN; ENDOTHELIAL-CELLS; RECEPTOR; LIGAND; IDENTIFICATION; IMMUNOGLOBULIN; INTERFERON; ACTIVATION; ADHERENCE AB The attachment of erythrocytes infected with P. falciparum to human venular endothelium is the primary step leading to complications from severe and cerebral malaria. Intercellular adhesion molecule-1 (ICAM-1, CD54) has been implicated as a cytoadhesion receptor for P. falciparum-infected erythrocytes. Characterization of domain deletion, human/murine chimeric ICAM-1 molecules, and amino acid substitution mutants localized the primary binding site for parasitized erythrocytes to the first amino-terminal immunoglobulin-like domain of ICAM-1. The ICAM-1 binding site is distinct f rom those recognized by LFA-1, Mac-1, and the human major-type rhinoviruses. Synthetic peptides encompassing the binding site on ICAM-1 inhibited malaria-infected erythrocyte adhesion to ICAM-1-coated surfaces with a K(i) of 0.1-0.3 mM, whereas the K(i) for soluble ICAM-1 is 0.15-mu-M. These findings have implications for the therapeutic reversal of malaria-infected erythrocyte sequestration in the host microvasculature. C1 WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. BOEHRINGER INGELHEIM PHARMACEUT INC,RIDGEFIELD,CT 06877. HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115. HARVARD UNIV,SCH MED,CTR BLOOD RES,BOSTON,MA 02115. RP OCKENHOUSE, CF (reprint author), WALTER REED ARMY MED CTR,INST RES,WASHINGTON,DC 20307, USA. FU NCI NIH HHS [CA31798] NR 29 TC 130 Z9 131 U1 0 U2 1 PU CELL PRESS PI CAMBRIDGE PA 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 SN 0092-8674 J9 CELL JI Cell PD JAN 10 PY 1992 VL 68 IS 1 BP 63 EP 69 DI 10.1016/0092-8674(92)90206-R PG 7 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA GZ583 UT WOS:A1992GZ58300009 PM 1346257 ER PT J AU MOUL, JW AF MOUL, JW TI INAPPROPRIATE SURGERY FOR TESTICULAR CANCER SO BRITISH JOURNAL OF HOSPITAL MEDICINE LA English DT Letter ID TUMOR C1 UNIFORMED SERV UNIV HLTH SCI,SURG,BETHESDA,MD 20814. RP MOUL, JW (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 6 TC 1 Z9 1 U1 0 U2 0 PU MARK ALLEN PUBLISHING LTD PI LONDON PA CROXTED MEWS, 286A-288 CROXTED ROAD, LONDON, ENGLAND SE24 9BY SN 0007-1064 J9 BRIT J HOSP MED JI Br. J. Hosp. Med. PD JAN 9 PY 1992 VL 47 IS 1 BP 73 EP 73 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA HC777 UT WOS:A1992HC77700019 PM 1737197 ER PT J AU CHATFIELD, DC FRIEDMAN, RS LYNCH, GC TRUHLAR, DG AF CHATFIELD, DC FRIEDMAN, RS LYNCH, GC TRUHLAR, DG TI QUANTIZED TRANSITION-STATE STRUCTURE IN THE CUMULATIVE REACTION PROBABILITIES FOR THE CL+HCL, I+HI, AND I+DI REACTIONS SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Article ID PHOTODETACHMENT SPECTRUM; COLLINEAR REACTIONS; HYDROGEN MOLECULES; CHEMICAL-REACTIONS; RATE CONSTANTS; EXCITED-STATE; SCATTERING; APPROXIMATION AB The cumulative reaction probabilities of Schatz for Cl + HCl, I + HI, and I + DI are analyzed by averaging them over an energy interval wider than the trapped state and rotational threshold structures and narrower than the quantized transition-state spacings. This analysis shows that the total reactivity is dominated by short-time dynamics in these cases and clearly reveals quantized transition-state structure underlying the other features. In all three cases we present a spectroscopic fit to the transition-state spectrum, and we compare the spectroscopic constants to those extracted from a variational transition-state theory analysis based on the adiabatic theory of reactions. C1 UNIV MINNESOTA,INST SUPERCOMP,DEPT CHEM,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55455. RI Truhlar, Donald/G-7076-2015 OI Truhlar, Donald/0000-0002-7742-7294 NR 59 TC 31 Z9 31 U1 0 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD JAN 9 PY 1992 VL 96 IS 1 BP 57 EP 63 DI 10.1021/j100180a015 PG 7 WC Chemistry, Physical SC Chemistry GA GZ697 UT WOS:A1992GZ69700015 ER PT J AU TSU, R SHEN, H DUTTA, M AF TSU, R SHEN, H DUTTA, M TI CORRELATION OF RAMAN AND PHOTOLUMINESCENCE SPECTRA OF POROUS SILICON SO APPLIED PHYSICS LETTERS LA English DT Article ID ALLOY SYSTEMS AB The discovery of luminescence in electrochemically etched porous silicon is an extremely important scientific breakthrough with enormous technological implications. It opens the door for silicon, the most important microelectronic material as a possible material for optoelectronics applications. Our result, a correlation of Raman and photoluminescence spectra, shows that the observed luminescence is originated from extremely small microstructures. As the luminescent peak increases in photon energy, the Raman feature shifts to lower energy, remaining sharp, and eventually splits, developing into TO and LO modes. No peak at 480 cm-1 is observed, which indicates no substantial contribution from an amorphous region. These data provide strong evidence of the role of microstructures in porous silicon. C1 USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. RP TSU, R (reprint author), UNIV N CAROLINA,CHARLOTTE,NC 28223, USA. NR 11 TC 220 Z9 233 U1 1 U2 13 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JAN 6 PY 1992 VL 60 IS 1 BP 112 EP 114 DI 10.1063/1.107364 PG 3 WC Physics, Applied SC Physics GA GY794 UT WOS:A1992GY79400039 ER PT J AU MURPHEY, BB HOGAN, AW AF MURPHEY, BB HOGAN, AW TI METEOROLOGICAL TRANSPORT OF CONTINENTAL SOOT TO ANTARCTICA SO GEOPHYSICAL RESEARCH LETTERS LA English DT Article ID SOUTH-POLE; AEROSOL AB An impactor/concentrator/microdensitometer (ICM) instrument system has been constructed and calibrated. This system is sufficiently sensitive to measure the black (carbon soot) component of Antarctic aerosol with a sampling time of four hours. The impactor concentrator was exposed to Antarctic air at Ross Island in September 1987. Microdensitometer analysis of the collected specimens indicates that the maximum black aerosol concentration was observed concurrently with the arrival of the warmest air accompanying a cyclonic storm. This is similar to the concurrence of continental radon and lead isotopes with warm advection, measured on the Antarctic coast by Polian et al. (1986). It is possible that continental soot can be transported to the Antarctic coast several times each year by this mechanism. C1 COLD REG RES & ENGN LAB,HANOVER,NH. RP MURPHEY, BB (reprint author), GEORGIA INST TECHNOL,SCH EARTH & ATMOSPHER SCI,ATLANTA,GA 30332, USA. NR 23 TC 6 Z9 7 U1 0 U2 3 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0094-8276 J9 GEOPHYS RES LETT JI Geophys. Res. Lett. PD JAN 3 PY 1992 VL 19 IS 1 BP 33 EP 36 DI 10.1029/91GL02912 PG 4 WC Geosciences, Multidisciplinary SC Geology GA GZ810 UT WOS:A1992GZ81000009 ER PT J AU ROGERS, KR ANIS, NA VALDES, JJ ELDEFRAWI, ME AF ROGERS, KR ANIS, NA VALDES, JJ ELDEFRAWI, ME TI FIBEROPTIC BIOSENSORS BASED ON TOTAL INTERNAL-REFLECTION FLUORESCENCE SO ACS SYMPOSIUM SERIES LA English DT Review ID NICOTINIC ACETYLCHOLINE-RECEPTOR; IMMUNOASSAY; SPECIFICITY; CHANNEL; BINDING; MUSCLE; TOXIN AB A signal transducer based on Total Internal Reflection Fluorescence has been coupled to three biological sensing elements to form receptor, enzyme and antibody biosensors. The nicotinic acetylcholine receptor biosensor is used to detect agonists and competitive antagonists of the receptor with detection limits for the antagonists, which are comparable to those obtained using radioisotope-labeled ligand binding assays. The acetylcholinesterase biosensor is used to detect anticholinesterases. The detection limit for each analyte depends on its potency as an anticholinesterase. Although compounds such as echothiophate and paraoxon yielded detection limits in the ppb range, the biosensor was not particularly sensitive to compounds such as parathion. An immunosensor is also described which uses antiparathion sera as the biological sensing element and detects parathion in the ppb range. C1 UNIV MARYLAND,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT,BALTIMORE,MD 21201. USA,CTR CHEM RES DEV & ENGN,EDGEWOOD,MD 21010. NR 22 TC 11 Z9 11 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0097-6156 J9 ACS SYM SER PY 1992 VL 511 BP 165 EP 173 PG 9 WC Chemistry, Multidisciplinary SC Chemistry GA KG218 UT WOS:A1992KG21800013 ER PT J AU RUNNION, K COMBIE, J WILLIAMSON, M AF RUNNION, K COMBIE, J WILLIAMSON, M TI THERMALLY STABLE UREASE FROM THERMOPHILIC BACTERIA SO ACS SYMPOSIUM SERIES LA English DT Review ID CAMPYLOBACTER-PYLORI; PURIFICATION; SULFUR; CHROMATIACEAE; NITROGEN; NIDULANS; PROTEIN AB Thermophilic microorganisms producing heat stable ureases have been isolated from the thermal waters of Yellowstone National Park in Wyoming. Conditions for optimized laboratory culturing were investigated as a means to achieve an economical methodology for the commercial production of an alternative stable enzyme used in clinical, industrial and environmental enzyme-based assays. Partially purified enzymes from ion exchange chromatography exhibited optimum activities within the pH range of 5.5 to 7.0 in citrate buffer. Although greater activities were expressed on increasing temperatures to 70-degrees-C acceptable activities could be attained at 25-degrees-C making these enzymes attractive for an array of applications. Stability analysis at 50-degrees-C for 209 hours revealed 94% activity retention compared to 7% retention for the conventionally used Jack Bean urease. C1 USA,CTR CHEM RES DEV & ENGN,DIV DETECT TECHNOL,ABERDEEN PROVING GROUND,MD 21010. RP RUNNION, K (reprint author), JK RES CORP,210 S WALLACE,BOZEMAN,MT 59715, USA. NR 41 TC 0 Z9 0 U1 1 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0097-6156 J9 ACS SYM SER PY 1992 VL 498 BP 42 EP 58 PG 17 WC Chemistry, Multidisciplinary SC Chemistry GA JG849 UT WOS:A1992JG84900005 ER PT J AU VANDERHOFF, JW HONG, SH HU, MR PARK, JM SEGALL, I WANG, S YUE, HJ AF VANDERHOFF, JW HONG, SH HU, MR PARK, JM SEGALL, I WANG, S YUE, HJ TI EMULSION COPOLYMERIZATION OF SMALL-PARTICLE-SIZE, HIGH-MOLECULAR-WEIGHT POLY(ALKYLAMINOALKYL METHACRYLATE-CO-ALKYL METHACRYLATE) LATEXES SO ACS SYMPOSIUM SERIES LA English DT Review ID SOLUTION BEHAVIOR; LIGHT-SCATTERING; POLY(ISOBUTYL AB High-molecular-weight compositionally-homogeneous viscoelastic poly(alkylaminoalkyl methacrylate-co-alkyl methacrylate) 's (e.g., 25:75 (molar ratio) poly(t-butylaminoethyl methacrylate-co-isobutyl methacrylate)) were prepared by semi-continuous emulsion copolymerization using persulfate ion initiator. The results were evaluated in terms of the expected proportionalities of the rate of polymerization to the number of polymer particles and the molecular weight to the number of particles relative to the rate of radical generation. The rates of polymerization were determined gravimetrically or by gas chromatography. The average particle sizes were inordinately small (18-86 nm), and the molecular weights were typically 10(6) daltons or greater. The small particle sizes were first attributed to the high emulsifier concentration and excellent stability of the latexes, and later to the failure of the latex particles containing only 8-11 polymer molecules to grow further. The high molecular weights were attributed to the large number of particles. The copolymer ratio, molecular weight, solubility, and viscoelastic properties in solution were determined, and the effect of the type of initiator (water-soluble or oil-soluble), polymerization temperature, emulsifier type and concentration, and monomer feed (emulsion or neat monomer) were investigated. The properties of laboratory copolymers were compared with those prepared in larger reactors. Generally, the viscoelastic properties were satisfactory. Analysis of the homogeneity of the copolymers by C-13 nuclear magnetic resonance spectrometry, Fourier-Transform infrared spectroscopy, differential scanning calorimetry, and transmission electron microscopy gave conflicting results. C1 LEHIGH UNIV,DEPT CHEM,BETHLEHEM,PA 18015. USA,CTR CHEM RES DEV & ENGN,RES DIRECTORATE,ABERDEEN PROVING GROUND,MD 21010. AIR PROD & CHEM CO INC,ALLENTOWN,PA 18195. RP VANDERHOFF, JW (reprint author), LEHIGH UNIV,INST EMULS POLYMERS,BETHLEHEM,PA 18015, USA. NR 14 TC 0 Z9 0 U1 1 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0097-6156 J9 ACS SYM SER PY 1992 VL 492 BP 216 EP 233 PG 18 WC Chemistry, Multidisciplinary SC Chemistry GA JB274 UT WOS:A1992JB27400015 ER PT B AU SCHREUDERGIBSON, HL STAPLER, JT LOH, IH AF SCHREUDERGIBSON, HL STAPLER, JT LOH, IH BE Boerio, FJ TI SURFACE MODIFICATION OF BALLISTIC FIBERS SO ADHESION SOCIETY PROCEEDINGS OF THE FIFTEENTH ANNUAL MEETING LA English DT Proceedings Paper CT 15th Annual Meeting of the Adhesion-Society CY FEB 16-19, 1992 CL HILTON HEAD ISL, SC SP ADHES SOC C1 USA,CTR RES DEV & ENGN,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ADHESION SOCIETY PI BALTIMORE PA MARTIN MARIETTA LABORATORIES 1450 S ROLLING RD, BALTIMORE, MD 21227 PY 1992 BP 120 EP 122 PG 3 WC Materials Science, Coatings & Films SC Materials Science GA BA23L UT WOS:A1992BA23L00046 ER PT J AU SINGH, A MOSES, FM DEUSTER, PA AF SINGH, A MOSES, FM DEUSTER, PA TI VITAMIN AND MINERAL STATUS IN PHYSICALLY ACTIVE MEN - EFFECTS OF A HIGH-POTENCY SUPPLEMENT SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article DE VITAMIN-B; VITAMIN-A; VITAMIN-C; VITAMIN-E; ZINC; MAGNESIUM; CALCIUM; VITAMIN SUPPLEMENTATION; MINERAL SUPPLEMENTATION ID TRAINED WOMEN RUNNERS; ZINC STATUS; EXERCISE; CAROTENE; ADULTS; IRON AB Changes in nutritional status during supplementation with a high-potency multivitamin-mineral supplement were examined in 22 physically active men randomly assigned to take a supplement (n = 11) or placebo (n = 11) for approximately 12 wk. Four-day dietary intakes, blood concentrations, and urinary excretions of selected vitamins and minerals were measured before, during (approximately 6 and 12 wk), and after supplementation. No changes were observed in blood concentrations of vitamins A and C and measures of zinc, magnesium, and calcium status; the supplement provided < 300% of the recommended dietary allowance (RDA) of these nutrients. In contrast, blood concentrations of thiamin, riboflavin, vitamins B-6 and B-12, pantothenate, and biotin increased significantly (P < 0.05) by 6 wk to values that were maintained until the end of the supplementation. These vitamins were provided in amounts that ranged from 396% (biotin) to 6250% (vitamin B-6) of the RDA. Urinary excretions of these vitamins also increased during supplementation and both blood and urine values returned to presupplementation concentrations at approximately 13.5 wk postsupplementation. C1 WALTER REED ARMY MED CTR,GASTROENTEROL SERV,WASHINGTON,DC 20307. RP SINGH, A (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT MIL MED,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. RI Deuster, Patricia/G-3838-2015 OI Deuster, Patricia/0000-0002-7895-0888 NR 26 TC 13 Z9 14 U1 0 U2 1 PU AMER SOC CLINICAL NUTRITION PI BETHESDA PA 9650 ROCKVILLE PIKE, SUBSCRIPTIONS, RM L-2310, BETHESDA, MD 20814-3998 SN 0002-9165 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD JAN PY 1992 VL 55 IS 1 BP 1 EP 7 PG 7 WC Nutrition & Dietetics SC Nutrition & Dietetics GA GY414 UT WOS:A1992GY41400002 PM 1728807 ER PT J AU CARROUGHER, JG KADAKIA, SC PELUSO, F AF CARROUGHER, JG KADAKIA, SC PELUSO, F TI TORTILLA CORN CHIP-ASSOCIATED ESOPHAGEAL-PERFORATION - AN UNUSUAL PRESENTATION OF ACHALASIA SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Note ID LACERATION; SECONDARY; TEAR AB Laceration of the esophagus related to ingestion of tortilla corn chips has been described in the past. However, no cases of perforation of the esophagus are known to be associated with tortilla corn chip ingestion. We describe a case of previously undiagnosed achalasia in a patient who presented with an esophageal perforation after ingestion of tortilla corn chips. C1 BROOKE ARMY MED CTR,DEPT MED,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,GASTROENTEROL SERV,FT SAM HOUSTON,TX 78234. NR 11 TC 2 Z9 2 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD JAN PY 1992 VL 87 IS 1 BP 128 EP 131 PG 4 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA GX887 UT WOS:A1992GX88700028 PM 1728109 ER PT J AU DIEHL, LD GOO, EDH SUMIYE, L FERRELL, R AF DIEHL, LD GOO, EDH SUMIYE, L FERRELL, R TI REDUCING WASTE OF INTRAVENOUS SOLUTIONS SO AMERICAN JOURNAL OF HOSPITAL PHARMACY LA English DT Article DE ADMINISTRATION; COMMUNICATION; DOSAGE SCHEDULES; INJECTIONS; NUTRITION; PHARMACY, INSTITUTIONAL, HOSPITAL; PRESCRIPTIONS; STABILITY; WASTAGE AB A program to minimize the waste of i.v. drug solutions is outlined, and the results of audits to determine the effectiveness of the program are presented. The program for reducing i.v. solution waste at a 500-bed acute-care center involves measures to compound admixtures for individual shifts, recycle solutions, remove unused solutions from nursing units, use a standardized administration schedule and automatic stop orders, standardize total parenteral nutrient (TPN) solutions, use commercially prepared products when possible, verify telephone orders, and prepare labile products just before use. From January 1987 to January 1990, six 30-day audits were performed to determine the number of i.v. admixtures discarded. The audits showed the hospital's average rate of waste to be 3.27%, well below other published values. The medical and surgical intensive-care units, pediatrics wards, and general medicine units accounted for most of the waste, which was largely attributable to dosage changes and stat-type drugs ordered but never used. Poor communication between the pharmacy and the nursing units also contributed to sterile product waste. Although the audits showed that waste was already at a low level, they pointed out areas for further improvement. A computer linkup that gives physicians the formulas for i.v. solutions is being set up, the list of standardized TPN solution formulas is being expanded to include condition-specific solutions, and clinical pharmacists are establishing better communication with the nursing units. By using several methods to reduce the waste of i.v. solutions, a pharmacy department has limited the rate of waste to only 3.27%. C1 TRIPLER ARMY MED CTR,PHARM SERV,HONOLULU,HI 96859. NR 4 TC 10 Z9 10 U1 1 U2 1 PU AMER SOC HEALTH-SYSTEM PHARMACISTS PI BETHESDA PA 7272 WISCONSIN AVE, BETHESDA, MD 20814 SN 0002-9289 J9 AM J HOSP PHARM JI Am. J. Hosp. Pharm. PD JAN PY 1992 VL 49 IS 1 BP 106 EP 108 PG 3 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA GX443 UT WOS:A1992GX44300015 PM 1570849 ER PT J AU LYNCH, TJ POSSIDENTE, CJ CIOFFI, WG HEBERT, JC AF LYNCH, TJ POSSIDENTE, CJ CIOFFI, WG HEBERT, JC TI MULTIDISCIPLINARY PROTOCOL FOR DETERMINING AMINOGLYCOSIDE DOSAGE SO AMERICAN JOURNAL OF HOSPITAL PHARMACY LA English DT Article DE AMINOGLYCOSIDES; BLOOD LEVELS; DOSAGE; FORMS; HOSPITALS; NURSES; PHARMACISTS, HOSPITAL; PHARMACY, INSTITUTIONAL, HOSPITAL; PHYSICIANS; PROTOCOLS; TESTS, LABORATORY; TOXICITY ID CLINICAL PHARMACOKINETICS SERVICE; SERUM CONCENTRATIONS; MONITORING SERVICE; DOSING SERVICE; BACTEREMIA; PREDICTION; PROGRAM AB A protocol for determining optimal dosages of aminoglycosides early in therapy is described, and the effectiveness of the protocol is evaluated. The protocol was developed jointly by physicians and pharmacists at a 550-bed hospital to ensure that surgical patients prescribed aminoglycosides were quickly and consistently put on a safe and effective course of therapy. Physicians select an aminoglycoside and calculate a loading dose and initial maintenance dosage by using a nomogram printed on an antimicrobial order form. Nurses are trained to administer and document aminoglycoside doses accurately and to draw blood samples at the correct times. Pharmacists order serum aminoglycoside concentration assays, analyze the results, and recommend changes in dosage when necessary. To evaluate the effectiveness of the dosing protocol, the records of surgical patients treated before and after the protocol was in place were reviewed. Compared with the control group, a higher percentage of patients treated under the protocol were receiving therapeutic, nontoxic dosages of aminoglycosides within 48 hours of the start of therapy. In addition, fewer serum drug concentration tests were ordered per patient under the protocol, and the percentage of concentration determinations useful for analysis was higher. The mean duration of aminoglycoside therapy was identical before and after the protocol was instituted, and nephrotoxic reactions tended to be less common among the protocol patients. An aminoglycoside dosing protocol requiring the cooperation of pharmacists, nurses, and physicians provides a consistent, safe, and effective means of managing aminoglycoside therapy for the hospitalized patient. C1 USA,INST SURG RES,BURN STUDY BRANCH,SAN ANTONIO,TX. RP LYNCH, TJ (reprint author), MED CTR HOSP VERMONT,DEPT PHARM,COLCHESTER AVE,BURLINGTON,VT 05401, USA. NR 22 TC 5 Z9 5 U1 0 U2 0 PU AMER SOC HEALTH-SYSTEM PHARMACISTS PI BETHESDA PA 7272 WISCONSIN AVE, BETHESDA, MD 20814 SN 0002-9289 J9 AM J HOSP PHARM JI Am. J. Hosp. Pharm. PD JAN PY 1992 VL 49 IS 1 BP 109 EP 115 PG 7 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA GX443 UT WOS:A1992GX44300016 PM 1570850 ER PT J AU GREINER, TM GORDON, CC AF GREINER, TM GORDON, CC TI SECULAR TRENDS OF 22 BODY DIMENSIONS IN 4 RACIAL CULTURAL GROUPS OF AMERICAN MALES SO AMERICAN JOURNAL OF HUMAN BIOLOGY LA English DT Article ID SOCIOECONOMIC-FACTORS; UNITED-STATES; MASS INDEX; HEIGHT; STATURE; BRITISH; ADULTS; AGE; CHILDREN; COHORT AB Data from the recent U.S. Army Anthropometric Survey provide a unique opportunity to assess long-term changes in body dimensions within the Army population. This report considers secular trends for 22 body dimensions within four racial/cultural groups: Whites, Blacks, Hispanics, and Asian/Pacific Islanders. Individuals were grouped by year of birth into 5 year cohorts, spanning 1911 to 1970. Rates of secular change were calculated by regressing age-adjusted dimensions against birth year cohort. Results showed that almost all dimensions sustained statistically significant linear trends, the few exceptions occurring in Asian/Pacific Islanders. The greatest rates of change occurred in dimensions related to soft tissues rather than skeletal dimensions. This pattern is consistent with recent American cultural emphasis on health and physical fitness. The causes of the observed trends, insofar as they have been identified, are related to cultural processes. This suggests that biological forces play a diminished role in shaping the patterns of secular change. Therefore, it may be more appropriate to study secular change in groups that are culturally, rather than biologically, defined. C1 SUNY BINGHAMTON, DEPT ANTHROPOL, BINGHAMTON, NY 13901 USA. RP GREINER, TM (reprint author), USA, NATICK RES DEV & ENGN CTR, STRNC, YBA, NATICK, MA 01760 USA. RI Greiner, Thomas/B-3769-2010 NR 35 TC 8 Z9 8 U1 1 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1042-0533 EI 1520-6300 J9 AM J HUM BIOL JI Am. J. Hum. Biol. PY 1992 VL 4 IS 2 BP 235 EP 246 DI 10.1002/ajhb.1310040208 PG 12 WC Anthropology; Biology SC Anthropology; Life Sciences & Biomedicine - Other Topics GA HK839 UT WOS:A1992HK83900007 ER PT J AU GORDON, CC BRADTMILLER, B AF GORDON, CC BRADTMILLER, B TI INTEROBSERVER ERROR IN A LARGE-SCALE ANTHROPOMETRIC SURVEY SO AMERICAN JOURNAL OF HUMAN BIOLOGY LA English DT Article ID RELIABILITY; UNIVARIATE; PRECISION AB The adverse effects of interobserver error on morphometric population comparisons are well documented in the literature. While interobserver error can rarely be avoided, it can be minimized by having a single individual locate and mark relevant landmarks, by limiting the number of observers for each variable, and by reviewing repeated measures data daily to catch and correct measurer drift during data collection. In this study, two pairs of experts participated in interobserver error trials designed to pre-set observer error limits for use in the quality control of a large scale anthropometric survey. Repeatability data were also collected twice daily in the field and reviewed with the measurers. Interobserver errors obtained in the field were lower than those achieved by the experts for 27 of 30 dimensions. These results suggest that establishment of permissible interobserver error in advance of data collection and frequent review of repeated measurements during data collection can reduce the magnitude of interobserver error below that obtained by experts measuring in a laboratory setting. However, even differences of small magnitude can be serious when they are directional, and 17 of 30 dimensions exhibited statistically significant bias between measurers despite all quality control efforts. The magnitudes of interobserver error observed in this study have proven particularly useful in evaluating the biological relevance of statistically significant differences which are of relatively small magnitude. C1 ANTHROPOL RES PROJECT INC,YELLOW SPRINGS,OH 45387. RP GORDON, CC (reprint author), USA,NATICK RES DEV & ENGN CTR,SCI & ADV TECHNOL DIRECTORATE,STRNC,YBA,NATICK,MA 01760, USA. NR 24 TC 22 Z9 23 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 1042-0533 J9 AM J HUM BIOL JI Am. J. Hum. Biol. PY 1992 VL 4 IS 2 BP 253 EP 263 DI 10.1002/ajhb.1310040210 PG 11 WC Anthropology; Biology SC Anthropology; Life Sciences & Biomedicine - Other Topics GA HK839 UT WOS:A1992HK83900009 ER PT J AU TRUWIT, CL BARKOVICH, AJ KOCH, TK FERRIERO, DM AF TRUWIT, CL BARKOVICH, AJ KOCH, TK FERRIERO, DM TI CEREBRAL-PALSY - MR FINDINGS IN 40 PATIENTS SO AMERICAN JOURNAL OF NEURORADIOLOGY LA English DT Article DE CEREBRAL PALSY ID BIRTH ASPHYXIA; BRAIN-DAMAGE; TERM; CT; TOMOGRAPHY; DISORDERS; CHILDREN; PRETERM AB Purpose: We used MR to retrospectively analyze the brains of patients suffering from cerebral palsy, our aim being to determine MR's role in the assessment of brain damage and the relationship of pre-, peri-, and post-natal events to cerebral palsy. Methods: Forty patients (aged 1 month to 41 years) underwent MR scanning and findings were correlated with clinical histories in all cases. Results: Review of MR scans of 11 patients who had been born prematurely revealed findings of periventricular white matter damage, indicative of hypoxic-ischemic brain injury (82%), the chronology of which was difficult to determine. Among 29 patients who had been born at term, three major patterns emerged: (1), gyral anomalies, suggestive of polymicrogyria, consistent with mid-second trimester injury; (2), isolated periventricular leukomalacia reflecting late second- or early third-trimester injury; and (3), watershed cortical or deep gray nuclear damage, consistent with late third-trimester, perinatal or postnatal injury. In 16 (55%) of 29 patients born at term, MR findings of intrauterine brain damage were observed; in over half of these cases MR revealed developmental anomalies, which is nearly twice the rate reported in prior studies employing CT. Conclusion: Our results support a growing consensus that cerebral palsy in term infants is often the result of prenatal factors, and less commonly related to the perinatal period. C1 USA,DEPT MED,ACAD HLTH SCI,HSHA-GPS,FT SAM HOUSTON,TX 78234. UNIV CALIF SAN FRANCISCO,DEPT RADIOL,NEURORADIOL SECT,SAN FRANCISCO,CA 94143. UNIV CALIF SAN FRANCISCO,DEPT PEDIAT NEUROL,SAN FRANCISCO,CA 94143. SAN FRANCISCO GEN HOSP,DEPT PEDIAT NEUROL,SAN FRANCISCO,CA 94110. NR 29 TC 157 Z9 158 U1 1 U2 3 PU AMER SOC NEURORADIOLOGY PI OAK BROOK PA 2210 MIDWEST RD, OAK BROOK, IL 60521 SN 0195-6108 J9 AM J NEURORADIOL JI Am. J. Neuroradiol. PD JAN-FEB PY 1992 VL 13 IS 1 BP 67 EP 78 PG 12 WC Clinical Neurology; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA HA037 UT WOS:A1992HA03700012 PM 1595496 ER PT J AU HANSEN, KA OPSAHL, MS NIEMAN, LK BAKER, JR KLEIN, TA AF HANSEN, KA OPSAHL, MS NIEMAN, LK BAKER, JR KLEIN, TA TI NATURAL-KILLER-CELL ACTIVITY FROM PREGNANT SUBJECTS IS MODULATED BY RU-486 SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article DE NATURAL KILLER CELLS; PREGNANCY; RU-486 ID MURINE TROPHOBLAST; MEDIATED-IMMUNITY; CYTO-TOXICITY; SERUM FACTORS; NK CELLS; PROGESTERONE; INDUCTION; SENSITIVITY; LYMPHOCYTES; INTERFERON AB Natural killer cells form an integral component of the body's innate immune system. Natural killer cell activity is reduced during pregnancy, especially in the latter half. To investigate the role progesterone may play in immunomodulating natural killer cell activity during pregnancy, we evaluated the effect of RU 486 on natural killer cells isolated from pregnant subjects. Natural killer cell activity was measured with an 18-hour, Chromium 51 release, microcytotoxicity assay with K-562 cells as target cells. We demonstrated that RU 486, in a concentration range from 5 to 40-mu-mol/L, augmented natural killer activity threefold to fivefold over baseline. This augmentation of activity was suppressed to baseline by the addition of excess progesterone. The addition of hydrocortisone resulted in an insignificant reduction in this augmented activity. This study suggests that progesterone may play a role as an immunomodulating factor in maternal acceptance of the fetal allograft. C1 WALTER REED ARMY MED CTR, DEPT OBSTET & GYNECOL, WASHINGTON, DC 20307 USA. NATL NAVAL MED CTR, BETHESDA, MD 20814 USA. NICHHD, DEV ENDOCRINOL BRANCH, BETHESDA, MD 20892 USA. OI Opsahl, Michael/0000-0002-8754-7943 NR 28 TC 31 Z9 31 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 1992 VL 166 IS 1 BP 87 EP 90 PN 1 PG 4 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA HA451 UT WOS:A1992HA45100021 PM 1733224 ER PT J AU DOWLING, JP GEABANACLOCHE, J AF DOWLING, JP GEABANACLOCHE, J TI THE SPECULAR REFLECTION OF LIGHT OFF LIGHT SO AMERICAN JOURNAL OF PHYSICS LA English DT Article AB It is well known that any classical electromagnetic field obeys the superposition principle-a fact that would seem to preclude the interaction and hence the deflection of light with light in free space. Nevertheless, the permissible phenomenon of interference between light waves can be viewed as a type of interaction. It is shown that under certain circumstances it is possible to consistently interpret interference as the specular reflection of two electromagnetic waves off each other in the vacuum. C1 UNIV ARKANSAS,DEPT PHYS,FAYETTEVILLE,AR 72702. RP DOWLING, JP (reprint author), USA,MISSILE COMMAND,RES CTR DEV & ENGN,WEAPONS SCI,AMSMI RD WS,REDSTONE ARSENAL,AL 35898, USA. RI Gea-Banacloche, Julio/J-7546-2013; DOWLING, JONATHAN/L-2749-2013 OI Gea-Banacloche, Julio/0000-0001-9482-9060; NR 7 TC 3 Z9 3 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0002-9505 J9 AM J PHYS JI Am. J. Phys. PD JAN PY 1992 VL 60 IS 1 BP 28 EP 34 DI 10.1119/1.17038 PG 7 WC Education, Scientific Disciplines; Physics, Multidisciplinary SC Education & Educational Research; Physics GA GW620 UT WOS:A1992GW62000010 ER PT J AU ROBERTS, CR FIPPS, DR BRUNDAGE, JF WRIGHT, SE GOLDENBAUM, M ALEXANDER, SS BURKE, DS AF ROBERTS, CR FIPPS, DR BRUNDAGE, JF WRIGHT, SE GOLDENBAUM, M ALEXANDER, SS BURKE, DS TI PREVALENCE OF HUMAN T-LYMPHOTROPIC VIRUS IN CIVILIAN APPLICANTS FOR THE UNITED-STATES ARMED-FORCES SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID CELL LEUKEMIA-LYMPHOMA; TRANSMISSION; ANTIBODIES; DONORS; INFECTION; SPREAD; ATLA; SERA AB Background. The wide range in human T-lymphotropic virus (HTLV) seroprevalences reported worldwide has made estimates of seroprevalence difficult in unique populations. In this study, the seropositivity of young adult civilian applicants for the US Armed Forces was determined. Methods. Serum samples from nine geographic regions were screened by an Enzyme-Linked Immunosorbent Assay (ELISA), and repeatedly reactive samples were further tested by Western blot and radioimmunoprecipitation. Specimens were scored as positive when antibody to gag (p24) and env (gp46 or gp68) were detected. Results. Of the 43 750 samples analyzed, 18 were positive for HTLV antibodies. Ten (55%) were from males and eight (45%) were from females. Nine (90%) of the males and seven (87.5%) of the females were Black. Twelve of the positive samples (66.6%) were from the New York City region, which represented only 18.8% of the sample population. Conclusions. The overall HTLV seroprevalence of civilian applicants for the US Armed forces was 0.41 per 1000. This was higher than the seroprevalence reported for volunteer blood donors. C1 US MIL ENTRANCE PROC COMMAND,OPERAT PLANS & TRAINING DIRECTORATE,CHICAGO,IL. BIOTECH RES LABS INC,ROCKVILLE,MD. WALTER REED ARMY MED CTR,DIV RETROVIRUS,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DIV PREVENT MED,WASHINGTON,DC 20307. OI /0000-0002-5704-8094 NR 22 TC 5 Z9 5 U1 0 U2 0 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 1015 FIFTEENTH ST NW, WASHINGTON, DC 20005 SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JAN PY 1992 VL 82 IS 1 BP 70 EP 73 DI 10.2105/AJPH.82.1.70 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA HL399 UT WOS:A1992HL39900014 PM 1536338 ER PT J AU KELLY, TF RYAN, JB AF KELLY, TF RYAN, JB TI LACERATED ACHILLES-TENDON IN A COLLEGIATE HOCKEY PLAYER - A CASE-REPORT SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article RP KELLY, TF (reprint author), US MIL ACAD,KELLER ARMY HOSP,OFF DIRECTOR INTERCOLLEGIATE ATHLET,W POINT,NY 10996, USA. NR 0 TC 4 Z9 4 U1 0 U2 1 PU AMER ORTHOPAEDIC SOC SPORT MED PI WALTHAM PA 230 CALVARY STREET, WALTHAM, MA 02154 SN 0363-5465 J9 AM J SPORT MED JI Am. J. Sports Med. PD JAN-FEB PY 1992 VL 20 IS 1 BP 84 EP 87 DI 10.1177/036354659202000119 PG 4 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA HB593 UT WOS:A1992HB59300019 PM 1554079 ER PT J AU MORRIS, H EGERLAND, WO HANSEN, CE AF MORRIS, H EGERLAND, WO HANSEN, CE TI THE SIGN OF A SPECIAL FUNCTION SO AMERICAN MATHEMATICAL MONTHLY LA English DT Letter RP MORRIS, H (reprint author), USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MATHEMATICAL ASSOC AMER PI WASHINGTON PA 1529 18TH STREET NW, WASHINGTON, DC 20036 SN 0002-9890 J9 AM MATH MON JI Am. Math. Mon. PD JAN PY 1992 VL 99 IS 1 BP 62 EP 62 DI 10.2307/2324557 PG 1 WC Mathematics SC Mathematics GA GX191 UT WOS:A1992GX19100012 ER PT J AU BECKETT, DC AARTILA, TP MILLER, AC AF BECKETT, DC AARTILA, TP MILLER, AC TI CONTRASTS IN DENSITY OF BENTHIC INVERTEBRATES BETWEEN MACROPHYTE BEDS AND OPEN LITTORAL PATCHES IN EAU-GALLE LAKE, WISCONSIN SO AMERICAN MIDLAND NATURALIST LA English DT Article ID SUBMERSED MACROPHYTES; ZONATION; CRAYFISH; PREY AB Small areas that are barren of plants commonly occur amidst dense littoral zone vegetation of lakes. This study compared the benthic invertebrate communities of nonvegetated patches to those in the surrounding vegetated sediments in a Wisconsin lake. Mean benthic invertebrate densities in the sediments of Ceratophyllum demersum and Potamogeton nodosus beds were 13 and seven times, respectively, those of nearby nonvegetated areas within the littoral zone. The contrast in densities was especially striking for the gastropods Amnicola limosa and Gyraulus parvus, which were collected below Ceratophyllum at 162 times and 48 times, respectively, their densities in open areas. The conjecture that these density differences were due to a lack of a detrital food base in the nonvegetated areas was not supported by our investigation. The most likely explanations for such a contrast in invertebrate densities are: (1) disturbance effects in areas lacking plants, and (2) increased predator efficiencies in the open zones. Removal of macrophytes by herbicides, drawdown or mechanical means creates large expanses of open areas; our data indicate that macrophyte removal would result in a less diverse and much less abundant invertebrate fauna in littoral zone sediments. More than 90% of the invertebrates in 0-15 cm cores were found within the top 5 cm in nonvegetated areas as well as in sediments below a rooted macrophyte (Potomageton nodosus) and a nonrooted macrophyte (C. demersum). Despite the presence of its root system, which might oxidize the sediments, proportional abundances of invertebrates deeper in the sediments below Potamogeton were not greater than those below Ceratophyllum or in the open zones. C1 USA,ENGINEER WATERWAYS EXPT STN,ENVIRONM LAB,VICKSBURG,MS 39180. RP BECKETT, DC (reprint author), UNIV SO MISSISSIPPI,DEPT BIOL SCI,BOX 5018,HATTIESBURG,MS 39406, USA. NR 33 TC 45 Z9 46 U1 0 U2 12 PU AMER MIDLAND NATURALIST PI NOTRE DAME PA UNIV NOTRE DAME, BOX 369, ROOM 295 GLSC, NOTRE DAME, IN 46556 SN 0003-0031 J9 AM MIDL NAT JI Am. Midl. Nat. PD JAN PY 1992 VL 127 IS 1 BP 77 EP 90 DI 10.2307/2426324 PG 14 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA GZ653 UT WOS:A1992GZ65300009 ER PT J AU COMBS, RJ CATHEY, CT AF COMBS, RJ CATHEY, CT TI MEASUREMENT OF A MICHELSON INTERFEROMETER MIRROR VELOCITY SO ANALYTICAL INSTRUMENTATION LA English DT Article AB This article documents the design, construction, and implementation of a time interval analyzer (TIA) for measurement of the mirror velocity in a Michelson interferometer. The TIA, a precision counter measures the dynamic variation in the time intervals (i.e. frequency) of a signal. The helium-neon (HeNe) laser signal from the servo mirror control circuitry of a Michelson interferometer provides a nearly constant frequency source. The HeNe signal frequency is directly proportional to the interferometer mirror velocity. A constant mirror velocity is crucial to the proper operation of a Michelson interferometer which modulates the infrared radiation in a Fourier transform spectrometer. The TIA permits a critical evaluation of velocity variations in a single interferometer mirror scan via the time interval analysis of the HeNe laser signal. C1 TRI SQ ENGN,ORMOND BEACH,FL 32175. RP COMBS, RJ (reprint author), USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010, USA. NR 11 TC 6 Z9 6 U1 0 U2 2 PU MARCEL DEKKER INC PI NEW YORK PA 270 MADISON AVE, NEW YORK, NY 10016 SN 0743-5797 J9 ANAL INSTRUM PY 1992 VL 20 IS 4 BP 223 EP 256 PG 34 WC Chemistry, Analytical; Instruments & Instrumentation SC Chemistry; Instruments & Instrumentation GA JX507 UT WOS:A1992JX50700002 ER PT J AU TALBOT, BG ANDERSON, DR HARRIS, LW LENNOX, WJ AF TALBOT, BG ANDERSON, DR HARRIS, LW LENNOX, WJ TI SPECIFIC RADIOISOTOPIC ASSAY FOR CHOLINESTERASE SO ANALYTICAL LETTERS LA English DT Article DE RADIOMETRIC CHE ASSAY; LIQUID SCINTILLATION COUNTING; TITRAGRAPHIC CHE ASSAY; CHOLINESTERASE; ACETYLCHOLINE; DRUG ANALYSIS ID SOMAN; ACETYLCHOLINESTERASE; TOXICITY; MICE AB We have developed a radiometric method (I) for measuring cholinesterase (ChE) activity that uses 0.4 N perchloric acid (PCA), instead of p-dioxane (method II), to denature the ChE and stop hydrolysis of acetyl-1-C-14-choline (ACh). The unreacted ACh is removed by IRP-69 cationic exchange resin suspended in water, instead of dioxane. The supernatant (acidic water solution) containing the hydrolysis product, C-14-acetic acid, is mixed with nonhazardous scintillation cocktail and counted. The incubation mixture (37-degrees-C) of I is similar to II and contains 0.1 ml of buffer-salt solution (pH 7.8), 0.1 ml of guinea pig whole blood (WB)-water suspension and 0.1 ml of 3 mM ACh solution. Procedures I and II were compared to a titragraphic assay for ChE activity; specific activity values of WB (mmol ACh hydrolyzed/ml/hr) were found to be 137.6, 72.4 and 135.0, respectively. RP TALBOT, BG (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 17 TC 0 Z9 0 U1 0 U2 0 PU MARCEL DEKKER INC PI NEW YORK PA 270 MADISON AVE, NEW YORK, NY 10016 SN 0003-2719 J9 ANAL LETT JI Anal. Lett. PY 1992 VL 25 IS 2 BP 205 EP 218 PG 14 WC Chemistry, Analytical SC Chemistry GA HF972 UT WOS:A1992HF97200003 ER PT J AU ANIS, NA WRIGHT, J ROGERS, KR THOMPSON, RG VALDES, JJ ELDEFRAWI, ME AF ANIS, NA WRIGHT, J ROGERS, KR THOMPSON, RG VALDES, JJ ELDEFRAWI, ME TI A FIBEROPTIC IMMUNOSENSOR FOR DETECTING PARATHION SO ANALYTICAL LETTERS LA English DT Article DE FIBER OPTIC BIOSENSOR; PESTICIDE DETECTION; WAVE-GUIDE EVANESCENT FLUOROSENSORS; PARATHION IMMUNOSENSOR ID ENZYME AB Casein-parathion conjugates, immobilized by adsorption on quartz fibers, selectively adsorbed antiparathion rabbit antibodies raised against bovine serum albumin (BSA)-parathion conjugates from polyclonal immune sera. The presence of free parathion interfered with binding of the rabbit's antiparathion Abs. Fluorescein isothiocyanate (FITC) goat antirabbit IgG were used to generate an optical signal, which was measured by a signal transducer based on total internal reflection fluorescence. Inhibition of binding of rabbit Abs by free parathion, reduced the optical signal and provided the basis for detection of parathion with this optical immunosensor. It could detect 0.3 ppb parathion and was highly specific since its detection of the oxygen analog paraoxon was possible at 100-fold higher concentration. C1 UNIV MARYLAND,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT,BALTIMORE,MD 21201. USA,CTR RES DEV & ENGN,DIV BIOTECHNOL,EDGEWOOD,MD 21010. US EPA,EMSL LV,EAD,LAS VEGAS,NV 89193. NR 12 TC 28 Z9 30 U1 1 U2 2 PU MARCEL DEKKER INC PI NEW YORK PA 270 MADISON AVE, NEW YORK, NY 10016 SN 0003-2719 J9 ANAL LETT JI Anal. Lett. PY 1992 VL 25 IS 4 BP 627 EP 635 PG 9 WC Chemistry, Analytical SC Chemistry GA HM068 UT WOS:A1992HM06800001 ER PT J AU KRYZER, TC GONZALEZ, C BURGESS, LPA AF KRYZER, TC GONZALEZ, C BURGESS, LPA TI EFFECTS OF AEROSOLIZED DEXAMETHASONE ON ACUTE SUBGLOTTIC INJURY SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY LA English DT Article DE ANIMAL MODEL; LARYNGEAL INJURY; STEROID TREATMENT ID GRANULATION-TISSUE FORMATION; LOCAL METHYLPREDNISOLONE; STENOSIS AB Aerosolized dexamethasone was used in a two-phase study to determine the possible effects on acute subglottic injury in the ferret animal model. In phase 1, equivalent subglottic injuries were made in 10 animals by using the brush technique, and the animals were divided into two groups. The treatment group received aerosolized dexamethasone at 2, 4, and 6 hours postinjury. All animals were examined 2, 4, 6, and 24 hours after the injury. The clinical condition of each animal was evaluated and their airways were measured. The animals were then painlessly killed and the larynges were frozen, sectioned, and photographed at 1-mm intervals. A computer-linked digitizer pad was used to measure the subglottic dimensions. The results show a trend for the treated animals to have a larger subglottic airway as compared to the untreated (control) group. The phase 1 study, suggests that there may be an improvement in the subglottic airway when treated acutely with aerosolized dexamethasone. In phase 2, 20 additional animals were studied by using the same methods of injury and treatment as in phase 1. The subglottic airways of these animals were evaluated with histomorphometric analysis on fixed histologic sections. A statistically significant difference was found between the subglottic airways of the treated and untreated animals favoring treatment with aerosolized dexamethasone. Aerosolized dexamethasone appears to be beneficial in preserving the subglottic airway after injury, possibly secondary to decreasing the edema associated with injury. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. UNIFORMED SERV UNIV HLTH SCI,DEPT PEDIAT,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,OTOLARYNGOL HEAD & NECK SURG SERV,WASHINGTON,DC 20307. NR 8 TC 10 Z9 10 U1 0 U2 0 PU ANNALS PUBL CO PI ST LOUIS PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 SN 0003-4894 J9 ANN OTO RHINOL LARYN JI Ann. Otol. Rhinol. Laryngol. PD JAN PY 1992 VL 101 IS 1 BP 95 EP 99 PN 1 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA GZ220 UT WOS:A1992GZ22000017 PM 1728893 ER PT J AU ADAMS, GF SHAW, RW AF ADAMS, GF SHAW, RW TI CHEMICAL-REACTIONS IN ENERGETIC MATERIALS SO ANNUAL REVIEW OF PHYSICAL CHEMISTRY LA English DT Review DE UNIMOLECULAR DECOMPOSITION; RADICAL REACTIONS; QUANTUM CHEMISTRY MOLECULAR DYNAMICS; NITROGEN COMBUSTION CHEMISTRY; EXPLOSIVES AND PROPELLANTS ID HIGH-TEMPERATURE PHOTOCHEMISTRY; THERMAL-DECOMPOSITION KINETICS; CONDENSED-PHASE DECOMPOSITION; SOLID-PROPELLANT COMBUSTION; TANDEM MASS-SPECTROMETRY; NITROUS OXIDE FLAMES; STEADY-STATE FLAMES; GROUND-STATE; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE RDX; CYCLOTRIMETHYLENETRINITRAMINE RDX C1 USA, RES OFF, RES TRIANGLE PK, NC 27709 USA. RP ADAMS, GF (reprint author), USA, BALLIST RES LABS, ABERDEEN PROVING GROUND, MD 21005 USA. NR 86 TC 81 Z9 81 U1 3 U2 25 PU ANNUAL REVIEWS PI PALO ALTO PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 USA SN 0066-426X J9 ANNU REV PHYS CHEM JI Annu. Rev. Phys. Chem. PY 1992 VL 43 BP 311 EP 340 PG 30 WC Chemistry, Physical SC Chemistry GA JZ284 UT WOS:A1992JZ28400012 ER PT J AU LEDUC, JW CHILDS, JE GLASS, GE AF LEDUC, JW CHILDS, JE GLASS, GE TI THE HANTAVIRUSES, ETIOLOGIC AGENTS OF HEMORRHAGIC-FEVER WITH RENAL SYNDROME - A POSSIBLE CAUSE OF HYPERTENSION AND CHRONIC RENAL-DISEASE IN THE UNITED-STATES SO ANNUAL REVIEW OF PUBLIC HEALTH LA English DT Review DE RODENT-BORNE ZOONOSES; NEPHROPATHIA-EPIDEMICA; SEOUL VIRUS; PUUMALA VIRUS ID PROSPECT-HILL VIRUS; HANTAAN-LIKE VIRUS; NUCLEOTIDE-SEQUENCE ANALYSIS; SMALL MAMMAL COMMUNITIES; M-GENOME SEGMENT; NEPHROPATHIA-EPIDEMICA; CLETHRIONOMYS-GLAREOLUS; INTERSTITIAL NEPHRITIS; SEROLOGIC EVIDENCE; RAT-POPULATIONS C1 JOHNS HOPKINS UNIV, SCH HYG & PUBL HLTH, DEPT IMMUNOL & INFECT DIS, BALTIMORE, MD 21205 USA. RP LEDUC, JW (reprint author), USA, MED RES INST INFECT DIS, DIV DIS ASSESSMENT, FT DETRICK, FREDERICK, MD 21702 USA. RI Childs, James/B-4002-2012 NR 104 TC 39 Z9 40 U1 0 U2 0 PU ANNUAL REVIEWS PI PALO ALTO PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 USA SN 0163-7525 J9 ANNU REV PUBL HEALTH JI Annu. Rev. Public Health PY 1992 VL 13 BP 79 EP 98 PG 20 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA HT577 UT WOS:A1992HT57700004 PM 1350911 ER PT J AU SPERLING, LC SAU, P AF SPERLING, LC SAU, P TI THE FOLLICULAR DEGENERATION SYNDROME IN BLACK PATIENTS - HOT COMB ALOPECIA REVISITED AND REVISED SO ARCHIVES OF DERMATOLOGY LA English DT Article ID TRANSVERSE AB Background.- The history, physical examination, and histologic findings in 10 black women with a common, distinctive form of scarring alopecia (formerly called hot comb alopecia) were retrospectively studied. A detailed history of hair care habits was obtained, and scalp biopsy specimens were examined after both vertical and transverse sectioning. Observations.- Poor correlation is noted between the usage of a hot comb and the onset or progression of disease. The earliest observable histologic abnormality is the premature desquamation of the inner root sheath. In severely affected follicles this is followed by a chain of histologic events leading to complete follicular degeneration. Conclusions.- The term follicular degeneration syndrome (FDS) is proposed for this clinically and histologically distinct form of scarring alopecia. Historical information is incompatible with the hypothesis that hot comb usage causes the alopecia. It remains unclear whether the use of any of a variety of hair care products and techniques plays a role in the pathogenesis of this condition. Premature desquamation of the inner root sheath serves as a histologic marker for FDS follicular degeneration syndrome, and may be an important pathogenetic factor. RP SPERLING, LC (reprint author), WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307, USA. NR 10 TC 93 Z9 94 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD JAN PY 1992 VL 128 IS 1 BP 68 EP 74 DI 10.1001/archderm.128.1.68 PG 7 WC Dermatology SC Dermatology GA GZ894 UT WOS:A1992GZ89400009 PM 1739290 ER PT J AU ODONNELL, BP DAWSON, NA WEISS, RB MYERS, CE JAMES, WD AF ODONNELL, BP DAWSON, NA WEISS, RB MYERS, CE JAMES, WD TI SURAMIN-INDUCED SKIN REACTIONS SO ARCHIVES OF DERMATOLOGY LA English DT Article ID ACQUIRED IMMUNODEFICIENCY SYNDROME; AIDS-RELATED COMPLEX; RED BLOOD-CELLS; ADRENOCORTICAL CARCINOMA; IMMUNE-RESPONSES; POROKERATOSIS; INVITRO; THERAPY; IMMUNOSUPPRESSION; KERATOACANTHOMA AB Background and Design.- Suramin sodium, a polysulfonated napthylurea, has been used for more than 70 years as a chemotherapeutic agent for a variety of diseases. In a phase II trial of suramin, 20 patients with metastatic prostate carcinoma refractory to hormonal manipulation were evaluated retrospectively for evidence of skin toxicity. Results.- Three types of skin reaction were noted: generalized, erythematous, maculopapular eruption (10 patients); keratoacanthoma (two patients); and disseminated superficial actinic porokeratosis (one patient). A total of 15 episodes of some form of skin reaction occurred in 13 patients. The maculopapular eruptions resolved in 3 to 5 days despite continued treatment with suramin. Conclusions.- Cutaneous toxicity was a frequent and, often, self-limited side effect of suramin therapy, occurring in 13 (65%) patients. Keratoacanthoma and disseminated superficial actinic porokeratosis have not previously been reported to occur with suramin therapy. The immunosuppressive effect of suramin may induce the keratoacanthoma and disseminated superficial actinic porokeratosis lesions. C1 WALTER REED ARMY MED CTR,MED ONCOL SECT,WASHINGTON,DC 20307. NCI,DIV CENT RES,CLIN ONCOL PROGRAM,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,HEMATOL ONCOL SERV,WASHINGTON,DC 20307. NR 38 TC 27 Z9 27 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD JAN PY 1992 VL 128 IS 1 BP 75 EP 79 DI 10.1001/archderm.128.1.75 PG 5 WC Dermatology SC Dermatology GA GZ894 UT WOS:A1992GZ89400010 PM 1531404 ER PT J AU HOLLAND, TT WEBER, CB JAMES, WD AF HOLLAND, TT WEBER, CB JAMES, WD TI TENDER PERIUNGUAL NODULES - DIAGNOSIS - MYRMECIA (DEEP PALMOPLANTAR WARTS) SO ARCHIVES OF DERMATOLOGY LA English DT Note C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP HOLLAND, TT (reprint author), ARMED FORCES INST PATHOL,WASHINGTON,DC 20306, USA. NR 6 TC 8 Z9 9 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD JAN PY 1992 VL 128 IS 1 BP 105 EP & PG 0 WC Dermatology SC Dermatology GA GZ894 UT WOS:A1992GZ89400020 PM 1739277 ER PT J AU LEVOYER, T CIOFFI, WG PRATT, L SHIPPEE, R MCMANUS, WF MASON, AD PRUITT, BA AF LEVOYER, T CIOFFI, WG PRATT, L SHIPPEE, R MCMANUS, WF MASON, AD PRUITT, BA TI ALTERATIONS IN INTESTINAL PERMEABILITY AFTER THERMAL-INJURY SO ARCHIVES OF SURGERY LA English DT Article; Proceedings Paper CT 11TH ANNUAL MEETING OF THE SURGICAL INFECTION SOC CY APR 08, 1991 CL FT LAUDERDALE, FL SP SURG INFECT SOC ID BACTERIAL TRANSLOCATION; BURN PATIENTS; SUGARS; RATS AB Alterations in intestinal permeability have been postulated to occur after thermal injury. We evaluated the status of intestinal permeability during the first 2 postburn weeks in 15 subjects by measuring the differential excretion of enterally administered lactulose and mannitol. The mean age and burn size of the patients were 32.7 +/- 3.6 years and 53.3% +/- 5.1% of the total body surface area, respectively. Ten healthy volunteers were also studied. The lactulose-mannitol excretion ratio was 0.159 +/- 0.017 for the patients and 0.017 +/- 0.003 for controls. The increased ratio did not correlate with burn size or postburn day. Patients who developed significant clinical infections during their first 2 postburn weeks had lactulose-mannitol ratios on postburn day 2 that were significantly higher than those of controls and patients who did not develop infections. This suggests a relationship between susceptibility to infection and early alterations in intestinal permeability. C1 USA,INST SURG RES,SGRD,USO B,FT SAM HOUSTON,TX 78234. NR 17 TC 102 Z9 102 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0004-0010 J9 ARCH SURG-CHICAGO JI Arch. Surg. PD JAN PY 1992 VL 127 IS 1 BP 26 EP 30 PG 5 WC Surgery SC Surgery GA GY416 UT WOS:A1992GY41600004 PM 1734847 ER PT B AU HARRISON, RJ AF HARRISON, RJ BE Argyropoulos, SA Carayannis, G TI ISSUES INVOLVED IN DESIGN OF A PROCESS REVISION CONSULTANT SO ARTIFICIAL INTELLIGENCE IN MATERIALS PROCESSING LA English DT Proceedings Paper CT International Symposium on Artificial Intelligence in Materials Processing, at the 31st Annual Conference of Metallurgists of CIM CY AUG 23-27, 1992 CL EDMONTON, CANADA SP CANADIAN INST MIN MET & PETR, MET SOC, COMP APPLICAT STANDING COMM C1 USA,MAT TECHNOL LAB,WATERTOWN,MA 02172. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CANADIAN INST MINING, METALLURGY AND PETROLEUM PI MONTREAL PA XEROX TOWER, 1 PLACE ALEXIS NIHON, 1210-3400 DE MAISONNEUVE BLVD, MONTREAL PQ H3Z 3B8, CANADA BN 0-919086-35-7 PY 1992 BP 213 EP 225 PG 13 WC Computer Science, Artificial Intelligence; Materials Science, Multidisciplinary SC Computer Science; Materials Science GA BB29T UT WOS:A1992BB29T00019 ER PT J AU SEAVER, M PEELE, JR RUBEL, GO AF SEAVER, M PEELE, JR RUBEL, GO TI GAS SCAVENGING OF INSOLUBLE VAPORS - CONDENSATION OF METHYL SALICYLATE VAPOR ONTO EVAPORATING DROPS OF WATER SO ATMOSPHERIC ENVIRONMENT PART A-GENERAL TOPICS LA English DT Article DE WATER DROP EVAPORATION; HENRY LAW; INSOLUBLE ORGANIC VAPOR; GAS SCAVENGING ID WIND-TUNNEL AB We have observed the evaporation of acoustically levitated water drops at 0 and 32% relative humidity in a moving gas stream which is nearly saturated with methyl salicylate vapor. The initial evaporation rate is characteristic of a pure water drop and gradually slows until the evaporation rate becomes that of pure methyl salicylate. The quantity of condensed methyl salicylate exceeds its Henry's law solubility in water by factors of more than 30-50. This apparent violation of Henry's law agrees with the concentration enhancements in the liquid phase found by Glotfelty et al. (1987, Nature 235,602-605) during their field measurements of organophorus pesticides in fog water. Under our conditions, visual evidence demonstrates the presence of two liquid phases, thus invalidating the use of Henry's law. A continuum evaporation-condensation model for an immiscible two-component system which accounts for evaporative self-cooling of the drop correctly predicts the amount of methyl salicylate condensed onto the water drops. C1 USA,ARMAMENT MUNIT & CHEM COMMAND,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. RP SEAVER, M (reprint author), USN,RES LAB,CODE 6540,WASHINGTON,DC 20375, USA. NR 8 TC 2 Z9 2 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0004-6981 J9 ATMOS ENVIRON A-GEN PY 1992 VL 26 IS 2 BP 205 EP 209 DI 10.1016/0960-1686(92)90301-Z PG 5 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA GR453 UT WOS:A1992GR45300001 ER PT J AU ANDREAS, EL GOSZ, JR DAHM, CN AF ANDREAS, EL GOSZ, JR DAHM, CN TI CAN LONG-PATH FTIR SPECTROSCOPY YIELD GAS FLUX MEASUREMENTS THROUGH A VARIANCE TECHNIQUE SO ATMOSPHERIC ENVIRONMENT PART A-GENERAL TOPICS LA English DT Article DE GAS FLUX; LONG-PATH FOURIER TRANSFORM INFRARED SPECTROSCOPY; MICROMETEOROLOGY; PATHAVERAGING; SCALAR VARIANCE; TURBULENT EXCHANGE; VARIANCE TECHNIQUE ID ATMOSPHERIC BOUNDARY-LAYER; SURFACE-LAYER; MICROMETEOROLOGICAL TECHNIQUES; DRAG COEFFICIENTS; SCALAR QUANTITIES; WATER-VAPOR; HEAT-FLUX; SEA ICE; TEMPERATURE; TURBULENCE AB Long-path Fourier transform infrared (FTIR) spectroscopy is capable of measuring concentrations of many environmentally important trace gases in the atmospheric surface layer over horizontal averaging paths of up to 1 km. If the FTIR could also measure the variance in gas concentration, we could conceivably use it to estimate the path-averaged, vertical flux of any gas that the FTIR can detect. The problem in measuring variances, however, is that the large sampling volume-which allows the FTIR to measure concentrations with the best resolution-degrades its response to the high-wavenumber turbulent fluctuations that contribute to the variance. In this paper, we use a model for the three-dimensional scalar spectrum to look at the effects of this volume averaging on the FTIR's ability to measure gas concentration variance. Our modeling suggests that there is no realistic configuration or sampling rate that will let the FTIR measure gas concentration variance in the surface layer. Its sampling volume must simply be so large that all turbulent fluctuations with wavenumbers from the dissipation region down to the vicinity of the spectral peak are irrevocably degraded. Our analysis identifies experiments that can test these predictions. Despite the FTIR's predicted inability to measure gas fluxes through the variance technique, we lastly show that it can still yield these fluxes through other micrometeorological techniques. C1 UNIV NEW MEXICO,DEPT BIOL,ALBUQUERQUE,NM 87131. RP ANDREAS, EL (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 44 TC 4 Z9 4 U1 1 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0004-6981 J9 ATMOS ENVIRON A-GEN PY 1992 VL 26 IS 2 BP 225 EP 233 DI 10.1016/0960-1686(92)90304-4 PG 9 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA GR453 UT WOS:A1992GR45300004 ER PT J AU CAI, WY LUKES, YG BURCH, HB DJUH, YY CARR, F WARTOFSKY, L RHOOMS, P DAVIS, J BAKER, JR BURMAN, KD AF CAI, WY LUKES, YG BURCH, HB DJUH, YY CARR, F WARTOFSKY, L RHOOMS, P DAVIS, J BAKER, JR BURMAN, KD TI ANALYSIS OF HUMAN TSH RECEPTOR GENE AND RNA TRANSCRIPTS IN PATIENTS WITH THYROID-DISORDERS SO AUTOIMMUNITY LA English DT Article; Proceedings Paper CT SATELLITE MEETING ON THYROID AUTOIMMUNITY CY SEP 15, 1991 CL MONTREAL, CANADA DE TSH RECEPTOR; GENE; THYROID AB Human TSH receptor (hTSH-R) gene and RNA transcripts were analyzed by Southern and Northern blots in patients with various thyroid disorders, and in tissue cell lines. A 1.4 Kb cDNA encoding the extracellular human TSH-R domain was used as a probe. Southern analysis revealed two constant bands of 11.0 and 5.0 Kb (hTSH-R) in the thyroid and human white cell samples studied. regardless of the disease process. Northern analysis showed a predominant band at about 4.4 Kb in the thyroid tissues.but not in non-thyroid tissue or cell lines tested. There were no gene rearrangements or abnormal transcripts in Graves' disease or multinodular goiter samples. In contrast, the labelled cDNA TSH-R probe did not bind to RNA isolated from 1 of 2 papillary cancer samples. A portion of the unique area of the h-TSH receptor (approximately nucleotides 1100-1230) was directly sequenced in thyroid glands from patients with Graves' disease, multinodular goiter, and differentiated thyroid cancer. No mutations or polymorphisms were identified in these samples, as compared to normal thyroid or control placenta, although further definition of sequence variation in other areas of the TSH receptor, as well as in more samples, needs to be performed. The present study indicates the normal patterns of DNA and RNA hybridization in a variety of thyroid tissues and disease states, and demonstrates that pathologic thyroid samples, with the possible exception of thyroid cancer, were not associated with specific nucleotide abnormalities in the unique area of the TSH receptor that was studied. C1 WALTER REED ARMY MED CTR,DEPT MED,ENDOCRINE METAB SERV,7D,WASHINGTON,DC 20307. NR 0 TC 5 Z9 6 U1 0 U2 0 PU HARWOOD ACAD PUBL GMBH PI READING PA C/O STBS LTD, PO BOX 90, READING, BERKS, ENGLAND RG1 8JL SN 0891-6934 J9 AUTOIMMUNITY JI Autoimmunity PY 1992 VL 13 IS 1 BP 43 EP 50 DI 10.3109/08916939209014634 PG 8 WC Immunology SC Immunology GA JJ347 UT WOS:A1992JJ34700007 PM 1420806 ER PT J AU WENGER, CB LATZKA, WA AF WENGER, CB LATZKA, WA TI EFFECTS OF PYRIDOSTIGMINE BROMIDE ON PHYSIOLOGICAL-RESPONSES TO HEAT, EXERCISE, AND HYPOHYDRATION SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID PERFORMANCE; DIAZEPAM; ATROPINE; STRESS AB Five men underwent eight heat stress tests (HSTs) at 35-degrees-C, each consisting of four 25-min treadmill walks (35% Vo2max), separated by 5-min rests, in four conditions: 1) 20% relative humidity (rh), subjects euhydrated and drinking ad libitum; 2) 20% rh, euhydrated; 3) 75% rh, euhydrated; and 4) 20% rh, hypohydrated 3% of body weight. In Conditions 2-4 subjects drank during the walks to maintain their pre-HST weight. In each condition we tested subjects once after 30 mg pyridostigmine bromide (PB) by mouth and once after placebo. PB lowered heart rate a mean of 3 beats/min overall, most with hypohydration. PB did not significantly affect rectal temperature (T(re)), but reduced the rise in T(re) during hypohydrated exercise. In Condition 2, chest skin temperature decreased more during exercise with PB. PB had no significant effect on other skin temperatures, sweating, hematocrit, hemoglobin, total plasma protein, osmolality, ad libitum drinking, rate of O2 uptake, or subject ratings of temperature, discomfort, or exertion. PB thus had little effect on physiological responses to moderate exercise-heat stress. RP WENGER, CB (reprint author), USA,DIV THERMAL PHYSIOL & MED,NATICK,MA 01760, USA. NR 20 TC 11 Z9 11 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD JAN PY 1992 VL 63 IS 1 BP 37 EP 45 PG 9 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA GY245 UT WOS:A1992GY24500007 PM 1550532 ER PT B AU BEHR, M TEZDUYAR, TE AF BEHR, M TEZDUYAR, TE BE Miller, JJH TI GALERKIN LEAST-SQUARES SPACE-TIME FINITE-ELEMENT METHOD FOR DEFORMING DOMAINS - RECENT DEVELOPMENTS SO BAIL VI: PROCEEDINGS OF THE SIXTH INTERNATIONAL CONFERENCE ON BOUNDARY AND INTERIOR LAYERS - COMPUTATIONAL AND ASYMPTOTIC METHODS LA English DT Proceedings Paper CT 6th International Conference on Boundary and Interior Layers - Computational and Asymptotic Methods CY AUG 18-20, 1992 CL COPPER MT, CO C1 UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,DEPT AEROSP ENGN & MECH,MINNEAPOLIS,MN 55415. RI Behr, Marek/H-5401-2011 OI Behr, Marek/0000-0003-4257-8276 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FRONT RANGE PRESS INC PI COPPER MT PA PO BOX 3162, COPPER MT, CO 80443-3162 BN 0-9631678-1-2 PY 1992 BP 81 EP 82 PG 2 WC Mathematics, Applied; Mechanics SC Mathematics; Mechanics GA BA43G UT WOS:A1992BA43G00029 ER PT J AU BASSEN, H LITOVITZ, T PENAFIEL, M MEISTER, R AF BASSEN, H LITOVITZ, T PENAFIEL, M MEISTER, R TI ELF INVITRO EXPOSURE SYSTEMS FOR INDUCING UNIFORM ELECTRIC AND MAGNETIC-FIELDS IN CELL-CULTURE MEDIA SO BIOELECTROMAGNETICS LA English DT Article DE DOSIMETRY; INDUCED ELECTRIC FIELD; INDUCED CURRENT ID ELECTROMAGNETIC-FIELDS AB Many in vitro experiments on the biological effects of extremely low frequency (ELF) electromagnetic fields utilize a uniform external magnetic flux density (B) to expose biological materials. A significant number of researchers do not measure or estimate the resulting electric field strength (E) or current density (J) in the sample medium. The magnitude and spatial distribution of the induced E field are highly dependent on the sample geometry and its relative orientation with respect to the magnetic field. We have studied the E fields induced in several of the most frequently used laboratory culture dishes and flasks under various exposure conditions. Measurements and calculations of the E field distributions in the aqueous sample volume in the containers were performed, and a set of simple, quantitative tables was developed. These tables allow a biological researcher to determine, in a straightforward fashion, the magnitudes and distributions of the electric fields that are induced in the aqueous sample when it is subjected to a uniform, sinusoidal magnetic field of known strength and frequency. In addition, we present a novel exposure technique based on a standard organ culture dish containing two circular, concentric annular rings. Exposure of the organ culture dish to a uniform magnetic field induces different average electric fields in the liquid medium in the inner and outer rings. Results of experiments with this system, which were reported in a separate paper, have shown the dominant role of the magnetically induced E field in producing specific biological effects on cells, in vitro. These results emphasize the need to report data about the induced E field in ELF in-vitro studies, involving magnetic field exposures. Our data tables on E and J in standard containers provide simple means to enable determination of these parameters. C1 WALTER REED ARMY MED CTR,DEPT MICROWAVE RES,WASHINGTON,DC 20307. CATHOLIC UNIV AMER,VITREOUS STATE LAB,WASHINGTON,DC 20064. CATHOLIC UNIV AMER,DEPT ELECT ENGN,WASHINGTON,DC 20064. NR 8 TC 56 Z9 56 U1 1 U2 9 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0197-8462 J9 BIOELECTROMAGNETICS JI Bioelectromagnetics PY 1992 VL 13 IS 3 BP 183 EP 198 DI 10.1002/bem.2250130303 PG 16 WC Biology; Biophysics SC Life Sciences & Biomedicine - Other Topics; Biophysics GA HP381 UT WOS:A1992HP38100002 PM 1590818 ER PT J AU CZERSKA, EM ELSON, EC DAVIS, CC SWICORD, ML CZERSKI, P AF CZERSKA, EM ELSON, EC DAVIS, CC SWICORD, ML CZERSKI, P TI EFFECTS OF CONTINUOUS AND PULSED 2450-MHZ RADIATION ON SPONTANEOUS LYMPHOBLASTOID TRANSFORMATION OF HUMAN-LYMPHOCYTES INVITRO SO BIOELECTROMAGNETICS LA English DT Article DE 2450-MHZ MICROWAVES; PULSED AND CONTINUOUS WAVES; THERMAL EFFECTS ID MICROWAVE; EXPOSURE AB Normal human lymphocytes were isolated from the peripheral blood of healthy donors. One-ml samples containing (10(6)) cells in chromosome medium 1 A were exposed for 5 days to conventional heating or to continuous wave (CW) or pulsed wave (PW) 2450-MHz radiation at non-heating (37-degrees-C) and various heating levels (temperature increases of 0.5, 1.0, 1.5, and 2-degrees-C). The pulsed exposures involved 1-mu-s pulses at pulse repetition frequencies from 100 to 1,000 pulses per second at the same average SAR levels as the CW exposures. Actual average SARs ranged to 12.3 W/kg. Following termination of the incubation period, spontaneous lymphoblastoid transformation was determined with an image analysis system. The results were compared among each of the experimental conditions and with sham-exposed cultures. At non-heating levels, CW exposure did not affect transformation. At heating levels both conventional and CW heating enhanced transformation to the same extent and correlate with the increases in incubation temperature. PW exposure enhanced transformation at non-heating levels. This finding is significant (P < .002). At heating levels PW exposure enhanced transformation to a greater extent than did conventional or CW heating. This finding is significant at the .02 level. We conclude that PW 2450-MHz radiation acts differently on the process of lymphoblastoid transformation in vitro compared with CW 2450-MHz radiation at the same average SARs. C1 UNIV MARYLAND,DEPT ELECT ENGN,COLL PK,MD 20742. US FDA,CTR DEVICES & RADIOL HLTH,ROCKVILLE,MD 20857. WALTER REED ARMY MED CTR,DEPT MICROWAVE RES,WASHINGTON,DC 20307. NR 17 TC 20 Z9 20 U1 0 U2 2 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0197-8462 J9 BIOELECTROMAGNETICS JI Bioelectromagnetics PY 1992 VL 13 IS 4 BP 247 EP 259 DI 10.1002/bem.2250130402 PG 13 WC Biology; Biophysics SC Life Sciences & Biomedicine - Other Topics; Biophysics GA JF337 UT WOS:A1992JF33700001 PM 1510735 ER PT J AU MATHUR, SP AKYEL, Y LU, ST AF MATHUR, SP AKYEL, Y LU, ST TI WHOLE-BODY MICROWAVE DOSIMETRY BASED ON A SINGLE, GRADIENT-LAYER CALORIMETER SO BIOELECTROMAGNETICS LA English DT Note DE SPECIFIC ABSORPTION RATE (SAR); RAT CARCASS; AVERAGE POWER DENSITY AB A simple, cost-effective, and accurate technique to measure the whole-body-averaged specific absorption rate (SAR) in Sprague-Dawley rat carcasses by a single-gradient-layer calorimeter is described. The results of SAR determinations showed a highly linear relation between the average power density of the incident field (1.25 GHz) and the normalized heat loading of the carcasses. C1 WALTER REED ARMY MED CTR,DEPT MICROWAVE RES,WASHINGTON,DC 20307. RP MATHUR, SP (reprint author), ERC BIOSERV CORP,MONTGOMERY EXECUT CTR,SUITE 222,6 MONTGOMERY VILLAGE AVE,GAITHERSBURG,MD 20879, USA. NR 4 TC 1 Z9 1 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0197-8462 J9 BIOELECTROMAGNETICS JI Bioelectromagnetics PY 1992 VL 13 IS 5 BP 435 EP 438 DI 10.1002/bem.2250130510 PG 4 WC Biology; Biophysics SC Life Sciences & Biomedicine - Other Topics; Biophysics GA JM999 UT WOS:A1992JM99900009 PM 1445424 ER PT J AU CARELLI, C HALBREICH, A BERNARD, J BIZZINI, B ACHOUR, A ZAGURY, JF LEBON, P POLLIOTTI, B FOLGHERA, S LAAROUBI, K ABOUDPIRAK, E LOWELL, G BURNY, A PICARD, O ZAGURY, D AF CARELLI, C HALBREICH, A BERNARD, J BIZZINI, B ACHOUR, A ZAGURY, JF LEBON, P POLLIOTTI, B FOLGHERA, S LAAROUBI, K ABOUDPIRAK, E LOWELL, G BURNY, A PICARD, O ZAGURY, D TI IMMUNOGENICITY OF COMBINED ANTI-HIV AND ANTISUPPRESSIVE VACCINE PREPARATIONS SO BIOMEDICINE & PHARMACOTHERAPY LA English DT Article DE HIV-1 VACCINE; IMMUNOSUPPRESSION; HIV-1 PEPTIDES ID LYMPHOCYTES AB HIV-1 antigens generate in man both a humoral and cellular immune reaction. However, in ARC/AIDS patients, the cellular response is inhibited by HIV-1 which induces an antiproliferative (suppressive) effect on activated T cells. To overcome this inhibition and up-regulate the cellular response, we designed a new vaccine strategy directed both against HIV-1 and immunosuppression and we used an immunizing preparation composed of HIV-1 antigens combined with immunoregulatory peptides prepared in a biologically inactivated but immunogenic form. In mice, this preparation induced anti-HIV-1 antibodies and a cell-mediated cytotoxicity directed against H2 restricted cells carrying HIV-1 antigens. C1 UNIV PARIS 06,PHYSIOL CELLULAIRE LAB,F-75230 PARIS 05,FRANCE. INST JEAN GODINOI,IMMUNOL LAB,F-51056 REIMS,FRANCE. INST PASTEUR,F-75724 PARIS 15,FRANCE. HOP ST VINCENT DE PAUL,F-75674 PARIS 14,FRANCE. WEIZMANN INST SCI,IL-76100 REHOVOT,ISRAEL. WALTER REED ARMY MED CTR,USA,RES UNIT ISRAEL,WASHINGTON,DC 20307. UNIV LIBRE BRUXELLES,B-1050 BRUSSELS,BELGIUM. HOP ST ANTOINE,F-75571 PARIS 12,FRANCE. RP CARELLI, C (reprint author), INSERM,U36,17 RUE FER MOULIN,F-75005 PARIS,FRANCE. NR 12 TC 12 Z9 12 U1 0 U2 0 PU EDITIONS SCIENTIFIQUES ELSEVIER PI PARIS CEDEX 15 PA 141 RUE JAVEL, 75747 PARIS CEDEX 15, FRANCE SN 0753-3322 J9 BIOMED PHARMACOTHER JI Biomed. Pharmacother. PY 1992 VL 46 IS 4 BP 149 EP 153 DI 10.1016/0753-3322(92)90022-Y PG 5 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA JE741 UT WOS:A1992JE74100004 PM 1421046 ER PT J AU MOELLER, KD WILLIAMS, GP STEINHAUSER, S HIRSCHMUGL, C SMITH, JC AF MOELLER, KD WILLIAMS, GP STEINHAUSER, S HIRSCHMUGL, C SMITH, JC TI HYDRATION-DEPENDENT FAR-INFRARED ABSORPTION IN LYSOZYME DETECTED USING SYNCHROTRON RADIATION SO BIOPHYSICAL JOURNAL LA English DT Note ID INELASTIC NEUTRON-SCATTERING; DYNAMICS; MYOGLOBIN; PROTEINS AB Using the National Synchrotron Light Source (NSLS) at Brookhaven far-infared absorption in the frequency range 15-45 cm-1 was detected in samples of lysozyme at different hydrations and in water. The absorption is due to the presence of low-frequency (picosecond timescale) motions in the samples, such as are calculated in molecular dynamics simulations. The form of the transmission profile is temperature independent but varies significantly with the degree of hydration of the protein. At higher hydrations the profile resembles closely that of pure water in the region 20-45 cm-1. At a low hydration marked differences are seen with, in particular, the appearance of a transmission minimum at 19 cm-1. The possible origins of the hydration dependence are discussed. The results demonstrate the usefulness of long-wavelength synchrotron radiation for the characterisation of biologically-important low-frequency motions in protein samples. C1 BROOKHAVEN NATL LAB,UPTON,NY 11973. USA,AMCCOM,PICATINNY ARSENAL,NJ 07806. CENS,DEPT BIOL CELLULAIRE & MOLEC,BIOPHYS PROT & MEMBRANES SECT,F-91191 GIF SUR YVETTE,FRANCE. RP MOELLER, KD (reprint author), FAIRLEIGH DICKINSON UNIV,DEPT PHYS,TEANECK,NJ 07666, USA. RI smith, jeremy/B-7287-2012 OI smith, jeremy/0000-0002-2978-3227 NR 14 TC 18 Z9 18 U1 2 U2 7 PU BIOPHYSICAL SOCIETY PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0006-3495 J9 BIOPHYS J JI Biophys. J. PD JAN PY 1992 VL 61 IS 1 BP 276 EP 280 PG 5 WC Biophysics SC Biophysics GA HA811 UT WOS:A1992HA81100025 PM 1540696 ER PT B AU FRIEDL, KE AF FRIEDL, KE BE Marriott, BM Grumstrupscott, J TI BODY-COMPOSITION AND MILITARY PERFORMANCE - ORIGINS OF THE ARMY STANDARDS SO BODY COMPOSITION AND PHYSICAL PERFORMANCE: APPLICATIONS FOR THE MILITARY SERVICES LA English DT Proceedings Paper CT Workshop on Body Composition and Physical Performance: Applications for the Military Services CY FEB 06, 1990 CL WASHINGTON, DC SP NATL ACAD SCI, INST MED, FOOD & NUTR BOARD, COMM MILITARY NUTR RES C1 USA,ENVIRONM MED RES INST,DIV OCCUPAT PHYSIOL,NATICK,MA 01760. NR 0 TC 8 Z9 8 U1 0 U2 1 PU NATL ACADEMY PRESS PI WASHINGTON PA 2101 CONSTITUTION AVE NW, PO BOX 285, WASHINGTON, DC 20055 BN 0-309-04586-X PY 1992 BP 31 EP 55 PG 25 WC Nutrition & Dietetics; Physiology; Sport Sciences SC Nutrition & Dietetics; Physiology; Sport Sciences GA BZ40F UT WOS:A1992BZ40F00003 ER PT B AU VOGEL, JA FRIEDL, KE AF VOGEL, JA FRIEDL, KE BE Marriott, BM Grumstrupscott, J TI ARMY DATA - BODY-COMPOSITION AND PHYSICAL CAPACITY SO BODY COMPOSITION AND PHYSICAL PERFORMANCE: APPLICATIONS FOR THE MILITARY SERVICES LA English DT Proceedings Paper CT Workshop on Body Composition and Physical Performance: Applications for the Military Services CY FEB 06, 1990 CL WASHINGTON, DC SP NATL ACAD SCI, INST MED, FOOD & NUTR BOARD, COMM MILITARY NUTR RES C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 12 Z9 13 U1 0 U2 1 PU NATL ACADEMY PRESS PI WASHINGTON PA 2101 CONSTITUTION AVE NW, PO BOX 285, WASHINGTON, DC 20055 BN 0-309-04586-X PY 1992 BP 89 EP 103 PG 15 WC Nutrition & Dietetics; Physiology; Sport Sciences SC Nutrition & Dietetics; Physiology; Sport Sciences GA BZ40F UT WOS:A1992BZ40F00006 ER PT B AU HARMAN, EA FRYKMAN, PN AF HARMAN, EA FRYKMAN, PN BE Marriott, BM Grumstrupscott, J TI THE RELATIONSHIP OF BODY-SIZE AND COMPOSITION TO THE PERFORMANCE OF PHYSICALLY DEMANDING MILITARY TASKS SO BODY COMPOSITION AND PHYSICAL PERFORMANCE: APPLICATIONS FOR THE MILITARY SERVICES LA English DT Proceedings Paper CT Workshop on Body Composition and Physical Performance: Applications for the Military Services CY FEB 06, 1990 CL WASHINGTON, DC SP NATL ACAD SCI, INST MED, FOOD & NUTR BOARD, COMM MILITARY NUTR RES C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 16 Z9 17 U1 0 U2 1 PU NATL ACADEMY PRESS PI WASHINGTON PA 2101 CONSTITUTION AVE NW, PO BOX 285, WASHINGTON, DC 20055 BN 0-309-04586-X PY 1992 BP 105 EP 118 PG 14 WC Nutrition & Dietetics; Physiology; Sport Sciences SC Nutrition & Dietetics; Physiology; Sport Sciences GA BZ40F UT WOS:A1992BZ40F00007 ER PT B AU JONES, BH BOVEE, MW KNAPIK, JJ AF JONES, BH BOVEE, MW KNAPIK, JJ BE Marriott, BM Grumstrupscott, J TI ASSOCIATIONS AMONG BODY-COMPOSITION, PHYSICAL-FITNESS, AND INJURY IN MEN AND WOMEN ARMY TRAINEES SO BODY COMPOSITION AND PHYSICAL PERFORMANCE: APPLICATIONS FOR THE MILITARY SERVICES LA English DT Proceedings Paper CT Workshop on Body Composition and Physical Performance: Applications for the Military Services CY FEB 06, 1990 CL WASHINGTON, DC SP NATL ACAD SCI, INST MED, FOOD & NUTR BOARD, COMM MILITARY NUTR RES C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 39 Z9 40 U1 0 U2 0 PU NATL ACADEMY PRESS PI WASHINGTON PA 2101 CONSTITUTION AVE NW, PO BOX 285, WASHINGTON, DC 20055 BN 0-309-04586-X PY 1992 BP 141 EP 173 PG 33 WC Nutrition & Dietetics; Physiology; Sport Sciences SC Nutrition & Dietetics; Physiology; Sport Sciences GA BZ40F UT WOS:A1992BZ40F00009 ER PT J AU BAKER, WJ WIEBE, VJ KOESTER, SK EMSHOFF, VD MAENPAA, JU WURZ, GT DEGREGORIO, MW AF BAKER, WJ WIEBE, VJ KOESTER, SK EMSHOFF, VD MAENPAA, JU WURZ, GT DEGREGORIO, MW TI MONITORING THE CHEMOSENSITIZING EFFECTS OF TOREMIFENE WITH FLOW-CYTOMETRY IN ESTROGEN-RECEPTOR NEGATIVE MULTIDRUG RESISTANT HUMAN BREAST-CANCER CELLS SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Article DE MULTIDRUG RESISTANCE; TOREMIFENE; FLOW CYTOMETRY ID DAUNORUBICIN; ADRIAMYCIN AB The clinical study of compounds that modulate multidrug resistance in cancer cells has been hindered by both the toxicities of these agents and the inability to monitor their effectiveness at a cellular level. The non-steroidal triphenylethylene toremifene is well tolerated clinically and can sensitize multidrug resistant cells to the effects of doxorubicin in vitro. The chemosensitizing properties of toremifene in estrogen receptor negative, multidrug resistant MDA-A1 human breast cancer cells were studied using flow cytometric analysis. Cell cycle kinetics of MDA-A1 cells were not significantly affected by treatment with either toremifene or doxorubicin alone, as the majority of cells remained in G0/G1. However, preincubation with toremifene for 70 hours followed by treatment with doxorubicin caused a marked shift of cells to G2, as cells appeared to be blocked in that phase of the cell cycle. This result was nearly identical to the effect of doxorubicin alone on doxorubicin-sensitive MDA-MB-231 breast cancer cells and can be interpreted as a "resensitization" by toremifene of MDA-A1 cells to doxorubicin. This chemosensitizing effect of toremifene was accompanied by an enhanced accumulation of doxorubicin in MDA-A1 cells (+110% after 70 hours pre-incubation with toremifene), and by a depression in protein kinase C activity in MDA-A1 cells that was maximal following 70 hours incubation with toremifene. Flow cytometry is a widely available technique that might be applied clinically to monitor at the cellular level the chemosensitizing effects of toremifene and other modulators of multidrug resistance. C1 UNIV TEXAS,HLTH SCI CTR,DEPT MED ONCOL,7703 FLOYD CURL DR,SAN ANTONIO,TX 78284. BROOKE ARMY MED CTR,SAN ANTONIO,TX. UNIV TURKU,SF-20500 TURKU 50,FINLAND. NR 14 TC 17 Z9 17 U1 0 U2 0 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PY 1992 VL 24 IS 1 BP 43 EP 49 DI 10.1007/BF01832357 PG 7 WC Oncology SC Oncology GA KA963 UT WOS:A1992KA96300006 PM 1463871 ER PT J AU KRYWICKI, RF YEE, D AF KRYWICKI, RF YEE, D TI THE INSULIN-LIKE GROWTH-FACTOR FAMILY OF LIGANDS, RECEPTORS, AND BINDING-PROTEINS SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Review DE INSULIN-LIKE GROWTH FACTORS; IGF-I; IGF-II; IGF RECEPTORS; IGF BINDING PROTEINS; GROWTH STIMULATION; INSULIN RECEPTORS ID MANNOSE 6-PHOSPHATE RECEPTOR; HUMAN-BREAST-CANCER; FACTOR-II RECEPTOR; HUMAN-SKIN FIBROBLASTS; HUMAN AMNIOTIC-FLUID; ADULT-RAT SERUM; APPROXIMATELY-20-KILODALTON BIOSYNTHETIC PRECURSOR; EXTRAPANCREATIC TUMOR HYPOGLYCEMIA; CELL-CONDITIONED MEDIUM; IGF-I AB The insulin-like growth factors (IGFs) have important roles in normal cellular growth and development. The IGFs have also been implicated in regulation of tumor cell growth. Two ligands, IGF-I and IGF-II, have been identified that are expressed in both fetal and adult tissues. They interact with at least two specific cell surface receptors. The type I IGF receptor is homologous to the insulin receptor in structure and has tyrosine kinase activity. The type II receptor is identical to the mannose-6-phosphate receptor known to be important in the trafficking of lysosomal enzymes; its role in IGF signal transduction is not clear. Furthermore, a hybrid receptor composed of subunits from the insulin receptor and the type I IGF receptor have been identified. In addition to these receptors, six different IGF binding proteins have been identified, which modulate the activity of the IGFs in various ways. Thus, there is great potential for complex interactions between the family members that could ultimately regulate normal and neoplastic cell growth. C1 UNIV TEXAS,HLTH SCI CTR,DEPT MED,DIV MED ONCOL,SAN ANTONIO,TX 78284. BROOKE ARMY MED CTR,DEPT MED,HEMATOL ONCOL SERV,FT SAM HOUSTON,TX 78234. NR 140 TC 46 Z9 47 U1 0 U2 2 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PY 1992 VL 22 IS 1 BP 7 EP 19 DI 10.1007/BF01833329 PG 13 WC Oncology SC Oncology GA JM151 UT WOS:A1992JM15100003 PM 1384804 ER PT B AU Samples, CS AF Samples, CS BE Covel, J TI Animal tracks that walk away - ''I made tracks at Albeni Falls'' SO BRIDGES TO UNDERSTANDING LA English DT Proceedings Paper CT 1992 National Interpreters Workshop on Bridges to Understanding - Spanning the Gap Between Talk and Action CY NOV 05-10, 1992 CL SANTA CLARA, CA SP Natl Assoc Interpretat DE animal tracks; publicity; awareness C1 USA,CORPS ENGINEERS,PRIEST RIVER,ID 83356. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATIONAL ASSOCIATION INTERPRETATION PI FT COLLINS PA PO BOX 1892, FT COLLINS, CO 80522 PY 1992 BP 12 EP 15 PG 4 WC Education & Educational Research SC Education & Educational Research GA BE83V UT WOS:A1992BE83V00004 ER PT B AU Miller, G Vieira, A Chenoweth, D Tabb, GE AF Miller, G Vieira, A Chenoweth, D Tabb, GE BE Covel, J TI Bridging bureaucratic barriers: Improving communication between interpreters and managers SO BRIDGES TO UNDERSTANDING LA English DT Proceedings Paper CT 1992 National Interpreters Workshop on Bridges to Understanding - Spanning the Gap Between Talk and Action CY NOV 05-10, 1992 CL SANTA CLARA, CA SP Natl Assoc Interpretat DE bureaucracy; organizational structure; communication barriers; perceptions; conflict management; teamwork C1 USA,CORPS ENGINEERS,KANSAS CITY,MO 64106. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATIONAL ASSOCIATION INTERPRETATION PI FT COLLINS PA PO BOX 1892, FT COLLINS, CO 80522 PY 1992 BP 48 EP 49 PG 2 WC Education & Educational Research SC Education & Educational Research GA BE83V UT WOS:A1992BE83V00016 ER PT B AU Caravaglia, ED AF Caravaglia, ED BE Covel, J TI Invoke environmental compliance before it provokes you SO BRIDGES TO UNDERSTANDING LA English DT Proceedings Paper CT 1992 National Interpreters Workshop on Bridges to Understanding - Spanning the Gap Between Talk and Action CY NOV 05-10, 1992 CL SANTA CLARA, CA SP Natl Assoc Interpretat DE group participation; environmental compliance; environmental compliance standards; environmental stewardship; thinking processes C1 USA,CORPS ENGINEERS,WASHINGTON,DC 20314. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATIONAL ASSOCIATION INTERPRETATION PI FT COLLINS PA PO BOX 1892, FT COLLINS, CO 80522 PY 1992 BP 191 EP 192 PG 2 WC Education & Educational Research SC Education & Educational Research GA BE83V UT WOS:A1992BE83V00063 ER PT B AU Curran, M AF Curran, M BE Covel, J TI Let's interact: Developing am interactive video computer system to interpret your site SO BRIDGES TO UNDERSTANDING LA English DT Proceedings Paper CT 1992 National Interpreters Workshop on Bridges to Understanding - Spanning the Gap Between Talk and Action CY NOV 05-10, 1992 CL SANTA CLARA, CA SP Natl Assoc Interpretat DE interactive computer systems; natural resources; recreation; interactive video C1 USA,CORPS ENGINEERS,MARK TWAIN LAKE MANAGEMENT OFF,MONROE CITY,MO 63456. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATIONAL ASSOCIATION INTERPRETATION PI FT COLLINS PA PO BOX 1892, FT COLLINS, CO 80522 PY 1992 BP 203 EP 206 PG 4 WC Education & Educational Research SC Education & Educational Research GA BE83V UT WOS:A1992BE83V00069 ER PT B AU Dutton, DA AF Dutton, DA BE Covel, J TI Water safety interpretation: How to stay afloat! SO BRIDGES TO UNDERSTANDING LA English DT Proceedings Paper CT 1992 National Interpreters Workshop on Bridges to Understanding - Spanning the Gap Between Talk and Action CY NOV 05-10, 1992 CL SANTA CLARA, CA SP Natl Assoc Interpretat DE water safety; drowning; Personal Flotation Device C1 USA,CORPS ENGINEERS,SARDIS LAKE FIELD OFF,SARDIS,MS 38666. NR 0 TC 0 Z9 0 U1 1 U2 1 PU NATIONAL ASSOCIATION INTERPRETATION PI FT COLLINS PA PO BOX 1892, FT COLLINS, CO 80522 PY 1992 BP 354 EP 356 PG 3 WC Education & Educational Research SC Education & Educational Research GA BE83V UT WOS:A1992BE83V00117 ER PT J AU MONGAN, PD HOSKING, MP AF MONGAN, PD HOSKING, MP TI HYPERTHERMIA AFTER CARDIOPULMONARY BYPASS IN A CHILD SO CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE LA English DT Letter RP MONGAN, PD (reprint author), BROOKE ARMY MED CTR,DEPT SURG,ANESTHESIA & OPERAT SERV,FT SAM HOUSTON,TX 78234, USA. NR 3 TC 2 Z9 2 U1 0 U2 0 PU CANADIAN ANAESTHETISTS SOC INC PI TORONTO PA 1 EGLINTON AVE EAST, SUITE 208, TORONTO ON M4P 3A1, CANADA SN 0832-610X J9 CAN J ANAESTH JI Can. J. Anaesth.-J. Can. Anesth. PD JAN PY 1992 VL 39 IS 1 BP 99 EP 100 PG 2 WC Anesthesiology SC Anesthesiology GA GX666 UT WOS:A1992GX66600031 PM 1733547 ER PT J AU DAWSON, NA WILDING, G WEISS, RB MCLEOD, DG LINEHAN, WM FRANK, JA JACOB, JL GELMANN, EP AF DAWSON, NA WILDING, G WEISS, RB MCLEOD, DG LINEHAN, WM FRANK, JA JACOB, JL GELMANN, EP TI A PILOT TRIAL OF CHEMOHORMONAL THERAPY FOR METASTATIC PROSTATE CARCINOMA SO CANCER LA English DT Article ID CHEMOTHERAPY; CANCER AB Fifteen patients with previously untreated metastatic prostate cancer were treated on a pilot trial with a combination of maximal androgen blockade plus intermittent cytotoxic therapy after androgen priming to stimulate cell division. Androgen blockage was carried out using a gonadotropin-releasing hormone analog (leuprolide) plus a nonsteroidal antiandrogen (flutamide). Carboplatin (CBDCA)(800 mg/m2) was given intravenously every 28 days, preceded for 3 days and followed for 3 days by androgen treatment with fluoxymesterone (5 mg orally twice a day), during which time flutamide was discontinued. Three patients (20%) achieved a complete response (CR), and eight patients (53.3%) achieved a partial response (PR). Four patients (26.7%) had stable disease (SD). The median progression-free survival (PFS) time was 31 months. Nine of 15 patients (60%) remain alive with a median follow-up time of 42+ months (range, 22 to 54 months). Grade 4 thrombocytopenia and Grades 3 or 4 leukopenia were experienced in 87% and 80% of patients, respectively, requiring dose reductions of CBDCA in 85% of the cycles. Six of 15 patients experienced a flare in bone pain with androgen priming. There were no associated spinal cord compressions; however, exclusion of impending spinal cord compression was required before entrance on study. C1 WALTER REED ARMY MED CTR,DEPT UROL,WASHINGTON,DC 20307. NCI,DIV CANC TREATMENT,CLIN ONCOL PROGRAM,BETHESDA,MD 20892. RP DAWSON, NA (reprint author), WALTER REED ARMY MED CTR,DEPT MED,HEMATOL ONCOL SERV,WASHINGTON,DC 20307, USA. NR 21 TC 12 Z9 12 U1 0 U2 2 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD JAN 1 PY 1992 VL 69 IS 1 BP 213 EP 218 DI 10.1002/1097-0142(19920101)69:1<213::AID-CNCR2820690135>3.0.CO;2-V PG 6 WC Oncology SC Oncology GA GW428 UT WOS:A1992GW42800034 PM 1727665 ER PT J AU RUBEL, GO AF RUBEL, GO TI WATER ISOTHERM MEASUREMENTS FOR MICROPARTICLES OF CARBON SO CARBON LA English DT Article DE POROUS CARBON, WATER VAPOR ADSORPTION, MICROPARTICLES, ELECTRICAL LEVITATION ID ADSORPTION AB A new method, single particle electrodynamic levitation SPEL, has been used to measure the water isotherm for microparticles of porous carbon. SPEL is an ultrasensitive gravimetric analyzer that uses electric fields to levitate single microparticles in a flowing gas stream. The quantity of adsorbed vapor is directly proportional to the electric field intensity required to suspend the particle at the center of the levitater. Water isotherms for nanogram microparticles of BPL and ASC carbon are measured at 25-degrees-C using SPEL and compared to bulk carbon isotherm data. It is shown that SPEL can successfully differentiate the ASC and BPL carbon water isotherms and replicate standard isotherm data with only a limited number of single particle measurements. Hysteresis effects are also measurable with SPEL. RP RUBEL, GO (reprint author), USA,ARMAMENT MUNIT & CHEM COMMAND,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010, USA. NR 6 TC 5 Z9 5 U1 1 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0008-6223 J9 CARBON JI Carbon PY 1992 VL 30 IS 7 BP 1007 EP 1011 DI 10.1016/0008-6223(92)90129-K PG 5 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA JX727 UT WOS:A1992JX72700010 ER PT J AU HOLLINGER, J CHAUDHARI, A AF HOLLINGER, J CHAUDHARI, A TI BONE REGENERATION MATERIALS FOR THE MANDIBULAR AND CRANIOFACIAL COMPLEX SO CELLS AND MATERIALS LA English DT Article DE BONE; GROWTH FACTORS; BONE MORPHOGENETIC PROTEINS; OSTEOGENESIS; PEPTIDES; WOUND HEALING ID GROWTH-FACTOR-BETA; AFFINITY-CHROMATOGRAPHY; INDUCTIVE PROTEIN; BOVINE BONE; CELLS; HYDROXYAPATITE; BIOLOGY; FAMILY; MATRIX AB Due to different functional demands and vascularity, the mandibular and craniofacial complex require bone regenerating materials with physical and chemical properties that are different from long bone. However, certain common requirements to both locales must be addressed. Furthermore, reasons why the autograft and allogeneic bank bones are successful in regenerating bone need to be understood if the researcher is to develop satisfactory alternatives. The purpose of this paper is to review some of the requirements needed for bone regenerating materials for mandibular and craniofacial bone repair. In that effort, we have briefly described the autograft and allogeneic bank bones, animal wound models, quantitative assays, certain bone regenerating factors (growth factors and bone inductive proteins), and requirements of delivery systems for presenting bone regenerating factors to the osseous host bed. RP HOLLINGER, J (reprint author), WALTER REED ARMY MED CTR,INST DENT RES,PHYSIOL BRANCH,WASHINGTON,DC 20307, USA. NR 42 TC 32 Z9 32 U1 0 U2 2 PU SCANNING MICROSCOPY INT PI CHICAGO PA PO BOX 66507, AMF O'HARE, CHICAGO, IL 60666 SN 1051-6794 J9 CELL MATER JI Cells Mat. PY 1992 VL 2 IS 2 BP 143 EP 151 PG 9 WC Cell Biology; Medicine, Research & Experimental; Materials Science, Biomaterials SC Cell Biology; Research & Experimental Medicine; Materials Science GA JU596 UT WOS:A1992JU59600006 ER PT J AU MAXWELL, DM BRECHT, KM AF MAXWELL, DM BRECHT, KM TI QUANTITATIVE STRUCTURE ACTIVITY ANALYSIS OF ACETYLCHOLINESTERASE INHIBITION BY OXONO AND THIONO ANALOGS OF ORGANOPHOSPHORUS COMPOUNDS SO CHEMICAL RESEARCH IN TOXICOLOGY LA English DT Article ID INSECTICIDES; SERINE AB A comparison of the bimolecular rate constants (k(i)) for inhibition of electric eel acetylcholinesterase (AChE) by the oxono (i.e., P = O) and thiono (i.e., P = S) analogues of parathion, methylparathion, leptophos, fonofos, sarin, and soman revealed that the oxono/thiono ratios of k(i) values varied from 14 for soman to 1240 for parathion. Analysis of the relative importance of the dissociation equilibrium constant and the phosphorylation rate constant in producing this variation in k(i) values indicated that the oxono analogues had phosphorylation rate constant values that varied in a narrow range from 8- to 14-fold greater than their thiono counterparts, while the oxono/thiono ratios for dissociation constants varied widely from 1 for soman to 82 for fonofos. The lower affinities of thiono analogues for AChE probably resulted from differences in the hydrophobic binding of oxono and thiono analogues to the active site of AChE, inasmuch as the hydrophobicities (i.e., octanol/water partition coefficients) of thiono organophosphorus compounds were much greater than the hydrophobicities of their oxono analogues. Quantitative structure-activity analysis indicated that the hydrophobic effects of oxono and thiono moieties correlated with log k(i) for AChE inhibition to a greater extent (r2 = 0.79) than their electronic effects (r2 less-than-or-equal-to 0.48). These observations suggest that the differences in hydrophobicity of oxono and thiono analogues of organophosphorus compounds may be as important as their electronic differences in determining their effectiveness as AChE inhibitors. RP MAXWELL, DM (reprint author), USA,INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 23 TC 23 Z9 24 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0893-228X J9 CHEM RES TOXICOL JI Chem. Res. Toxicol. PD JAN-FEB PY 1992 VL 5 IS 1 BP 66 EP 71 DI 10.1021/tx00025a011 PG 6 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology SC Pharmacology & Pharmacy; Chemistry; Toxicology GA HB644 UT WOS:A1992HB64400012 PM 1581539 ER PT J AU HONG, SS ROMSTEDT, KJ FELLER, DR HSU, FL GEORGE, C CUPPS, TL LYON, RA MILLER, DD AF HONG, SS ROMSTEDT, KJ FELLER, DR HSU, FL GEORGE, C CUPPS, TL LYON, RA MILLER, DD TI RESOLUTION AND ADRENERGIC ACTIVITIES OF THE OPTICAL ISOMERS OF 4-[1-(1-NAPHTHYL)ETHYL]-1H-IMIDAZOLE SO CHIRALITY LA English DT Article DE ALPHA-ADRENERGIC; IMIDAYOLE ANALOGS; METETOMIDINE; ENANTIOMERS ID SELECTIVE ALPHA-2-ADRENOCEPTOR AGONIST; HEALTHY-VOLUNTEERS; MEDETOMIDINE; DEXMEDETOMIDINE AB Recently we synthesized a naphthalene analog of medetomidine, 4-[1-(1-naphthyl)ethyl]-1H-imidazole hydrochloride (1), and found it to be highly potent in adrenergic systems. The separation of optical isomers of this naphthalene analog was achieved by using the isomers of tartaric acid. The optical purities of the isomers were determined by HPLC using a chiral column. Using X-ray analysis the (+)-isomer was determined to have the S absolute configuration. It has been reported that the (+)-isomer of medetomidine (2) is the most potent enantiomer on alpha2-adrenergic receptors. There were both qualitative and quantitative differences in biological activities of the optical isomers of 1 in alpha1- and alpha2-adrenergic receptor systems of guinea pig ileum and human platelets. (+)-(S)-1, but not (-)-(R)-1 was a selective agonist of alpha2-mediated responses in ileum whereas (-)-(R)-1 was more potent than (+)-(S)-1 as an inhibitor of alpha2-mediated platelet aggregation. C1 OHIO STATE UNIV,COLL PHARM,DIV PHARMACOL,COLUMBUS,OH 43210. USA,CHEM RES,ABERDEEN PROVING GROUND,MD 21010. USN,RES LAB,WASHINGTON,DC 20375. PROCTER & GAMBLE CO,CINCINNATI,OH 45239. RP HONG, SS (reprint author), OHIO STATE UNIV,COLL PHARM,DIV MED CHEM & PHARMACOGNOSY,COLUMBUS,OH 43210, USA. NR 17 TC 7 Z9 7 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0899-0042 J9 CHIRALITY JI Chirality PY 1992 VL 4 IS 7 BP 432 EP 438 DI 10.1002/chir.530040706 PG 7 WC Chemistry, Medicinal; Chemistry, Analytical; Chemistry, Organic; Pharmacology & Pharmacy SC Pharmacology & Pharmacy; Chemistry GA JW318 UT WOS:A1992JW31800005 PM 1361151 ER PT J AU EICKHORST, AG AF EICKHORST, AG TI BARGE TRANSPORTATION STILL BEST BET SO CIVIL ENGINEERING LA English DT Letter RP EICKHORST, AG (reprint author), USA,CORPS ENGINEERS,ECON & SOCIAL ANAL BRANCH,ST LOUIS,MO 63120, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0885-7024 J9 CIVIL ENG JI Civil Eng. PD JAN PY 1992 VL 62 IS 1 BP 28 EP 28 PG 1 WC Engineering, Civil SC Engineering GA GX463 UT WOS:A1992GX46300002 ER PT J AU KONKOL, KA LONGFIELD, RN POWERS, NR MEHR, Z AF KONKOL, KA LONGFIELD, RN POWERS, NR MEHR, Z TI WOUND MYIASIS CAUSED BY COCHLIOMYIA-HOMINIVORAX SO CLINICAL INFECTIOUS DISEASES LA English DT Letter C1 BROOKE ARMY MED CTR,PREVENT MED SERV,FT SAM HOUSTON,TX 78234. RP KONKOL, KA (reprint author), BROOKE ARMY MED CTR,DEPT MED,INFECT DIS SERV,FT SAM HOUSTON,TX 78234, USA. NR 8 TC 8 Z9 9 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JAN PY 1992 VL 14 IS 1 BP 366 EP 366 PG 1 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA HD517 UT WOS:A1992HD51700059 PM 1571457 ER PT J AU SHANLEY, DJ BUCKNER, AB AF SHANLEY, DJ BUCKNER, AB TI SOFT-TISSUE UPTAKE ON BONE-SCAN IN A PATIENT WITH UREMIC MYOPATHY SO CLINICAL NUCLEAR MEDICINE LA English DT Note C1 TRIPLER ARMY MED CTR,DEPT RADIOL & NUCL MED,HONOLULU,HI 96859. NR 3 TC 3 Z9 3 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD JAN PY 1992 VL 17 IS 1 BP 65 EP 66 DI 10.1097/00003072-199201000-00021 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA HA595 UT WOS:A1992HA59500021 PM 1544267 ER PT J AU TONEY, MO BROWN, JW HEIRONIMUS, JD ROSENBLATT, S BOYKIN, M AF TONEY, MO BROWN, JW HEIRONIMUS, JD ROSENBLATT, S BOYKIN, M TI CORRELATIVE IMAGING IN A PATIENT WITH NECROTIC ADRENAL PHEOCHROMOCYTOMA SO CLINICAL NUCLEAR MEDICINE LA English DT Note RP TONEY, MO (reprint author), BROOKE ARMY MED CTR,DEPT RADIOL,NUCL MED SERV,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD JAN PY 1992 VL 17 IS 1 BP 67 EP 68 DI 10.1097/00003072-199201000-00022 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA HA595 UT WOS:A1992HA59500022 PM 1544268 ER PT J AU ANDERSON, G HUI, D AF ANDERSON, G HUI, D TI USE OF COMPOSITES IN ROTORCRAFT AND SMART STRUCTURES - FOREWORD SO COMPOSITES ENGINEERING LA English DT Editorial Material C1 UNIV NEW ORLEANS,DEPT MECH ENGN,NEW ORLEANS,LA 70148. RP ANDERSON, G (reprint author), USA,RES OFF,RES TRIANGLE PK,NC 27709, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0961-9526 J9 COMPOS ENG JI Compos. Eng. PY 1992 VL 2 IS 5-7 BP R7 EP R7 DI 10.1016/0961-9526(92)90027-4 PG 1 WC Engineering, Multidisciplinary; Materials Science, Composites SC Engineering; Materials Science GA HZ762 UT WOS:A1992HZ76200001 ER PT J AU PARK, OC AF PARK, OC TI INSTRUCTIONAL APPLICATIONS OF HYPERMEDIA - FUNCTIONAL FEATURES, LIMITATIONS, AND RESEARCH ISSUES SO COMPUTERS IN HUMAN BEHAVIOR LA English DT Article ID COMPUTER-ASSISTED-INSTRUCTION; ADVISEMENT; DESIGN AB Hypermedia has enabled us to create a new instructional development and delivery environment. However, there are both theoretical and practical issues to be resolved and technical limitations to be overcome. To clarify the issues and limitations, the basic concept and database structures of hypermedia are briefly reviewed. Second, important functional requirements for the instructional application of hypermedia are described. Finally, several research issues that need to be examined in the application of hypermedia are proposed. RP PARK, OC (reprint author), USA,RES INST,5001 EISENHOWER AVE,ALEXANDRIA,VA 22333, USA. NR 40 TC 1 Z9 1 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0747-5632 J9 COMPUT HUM BEHAV JI Comput. Hum. Behav. PY 1992 VL 8 IS 2-3 BP 259 EP 272 DI 10.1016/0747-5632(92)90010-C PG 14 WC Psychology, Multidisciplinary; Psychology, Experimental SC Psychology GA HV921 UT WOS:A1992HV92100010 ER PT J AU RACH, R ADOMIAN, G MEYERS, RE AF RACH, R ADOMIAN, G MEYERS, RE TI A MODIFIED DECOMPOSITION SO COMPUTERS & MATHEMATICS WITH APPLICATIONS LA English DT Article AB The Maclaurin series is quite limited in comparison to the (Adomian) series obtained in the decomposition method. By adding procedures from the decomposition method and the expansion of nonlinearities using the Adomian polynomials, as well as a recent result of Adomian and Rach on transformation of series using the above polynomials, the Maclaurin series can be made much more useful in its applicability. However, the convergence is still slower than for Adomian's results using decomposition. C1 USA,ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002. RP RACH, R (reprint author), KRIEGER ASSOCIATES,1438 LUPINE DR ST,JOSEPH,MI 49085, USA. NR 7 TC 35 Z9 35 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0898-1221 J9 COMPUT MATH APPL JI Comput. Math. Appl. PD JAN PY 1992 VL 23 IS 1 BP 17 EP 23 DI 10.1016/0898-1221(92)90076-T PG 7 WC Mathematics, Applied SC Mathematics GA GY674 UT WOS:A1992GY67400002 ER PT B AU THIES, PR AF THIES, PR BE Clewell, HJ TI UNITED-STATES-ARMY APPROACH TO ENVIRONMENTAL RISK ASSESSMENT SO CONFERENCE ON CHEMICAL RISK ASSESSMENT IN THE DEPARTMENT OF DEFENSE (DOD): SCIENCE, POLICY, AND PRACTICE LA English DT Meeting Abstract CT Conference on Chemical Risk Assessment in the Department of Defense (DoD) - Science, Policy, and Practice CY APR 09-11, 1991 CL DAYTON, OH SP ARMSTRONG LAB, OCCUPAT & ENVIRONM HLTH DIRECTORATE, TOXICOL DIV, NAVAL MED RES INST, TOXICOL DETACHMENT, ARMY BIOMED RES & DEV LAB, NATL RES COUNCIL COMM TOXICOL C1 USA,ENVIRONM HYG AGCY,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CONFERENCE GOVERNMENTAL INDUSTRIAL HYGIENISTS PI CINCINNATI PA 6500 GLENWAY AVE, BLDG D-7, CINCINNATI, OH 45211 BN 0-936712-90-2 PY 1992 BP 9 EP 9 PG 1 WC Public, Environmental & Occupational Health; Toxicology SC Public, Environmental & Occupational Health; Toxicology GA BC41F UT WOS:A1992BC41F00002 ER PT B AU PARMER, DL PALMER, WG SMART, DA FINCH, RA AF PARMER, DL PALMER, WG SMART, DA FINCH, RA BE Clewell, HJ TI DEVELOPMENTAL MEDICAL RESEARCH ON LIQUID GUN PROPELLANTS SO CONFERENCE ON CHEMICAL RISK ASSESSMENT IN THE DEPARTMENT OF DEFENSE (DOD): SCIENCE, POLICY, AND PRACTICE LA English DT Proceedings Paper CT Conference on Chemical Risk Assessment in the Department of Defense (DoD) - Science, Policy, and Practice CY APR 09-11, 1991 CL DAYTON, OH SP ARMSTRONG LAB, OCCUPAT & ENVIRONM HLTH DIRECTORATE, TOXICOL DIV, NAVAL MED RES INST, TOXICOL DETACHMENT, ARMY BIOMED RES & DEV LAB, NATL RES COUNCIL COMM TOXICOL C1 USA,BIOMED RES & DEV LAB,FREDERICK,MD 21702. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER CONFERENCE GOVERNMENTAL INDUSTRIAL HYGIENISTS PI CINCINNATI PA 6500 GLENWAY AVE, BLDG D-7, CINCINNATI, OH 45211 BN 0-936712-90-2 PY 1992 BP 95 EP 104 PG 10 WC Public, Environmental & Occupational Health; Toxicology SC Public, Environmental & Occupational Health; Toxicology GA BC41F UT WOS:A1992BC41F00018 ER PT B AU GARDNER, H STACHIW, K AF GARDNER, H STACHIW, K BE Clewell, HJ TI SITE-SPECIFIC ENVIRONMENTAL ASSESSMENT SO CONFERENCE ON CHEMICAL RISK ASSESSMENT IN THE DEPARTMENT OF DEFENSE (DOD): SCIENCE, POLICY, AND PRACTICE LA English DT Meeting Abstract CT Conference on Chemical Risk Assessment in the Department of Defense (DoD) - Science, Policy, and Practice CY APR 09-11, 1991 CL DAYTON, OH SP ARMSTRONG LAB, OCCUPAT & ENVIRONM HLTH DIRECTORATE, TOXICOL DIV, NAVAL MED RES INST, TOXICOL DETACHMENT, ARMY BIOMED RES & DEV LAB, NATL RES COUNCIL COMM TOXICOL C1 USA,BIOMED RES & DEV LAB,FREDERICK,MD 21702. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CONFERENCE GOVERNMENTAL INDUSTRIAL HYGIENISTS PI CINCINNATI PA 6500 GLENWAY AVE, BLDG D-7, CINCINNATI, OH 45211 BN 0-936712-90-2 PY 1992 BP 105 EP 105 PG 1 WC Public, Environmental & Occupational Health; Toxicology SC Public, Environmental & Occupational Health; Toxicology GA BC41F UT WOS:A1992BC41F00019 ER PT B AU GAYDOS, JC AF GAYDOS, JC BE Clewell, HJ TI A HISTORICAL REVIEW OF THE NEED FOR MILITARY TOXICOLOGY AND THE UNITED-STATES ARMY RESPONSE SO CONFERENCE ON CHEMICAL RISK ASSESSMENT IN THE DEPARTMENT OF DEFENSE (DOD): SCIENCE, POLICY, AND PRACTICE LA English DT Proceedings Paper CT Conference on Chemical Risk Assessment in the Department of Defense (DoD) - Science, Policy, and Practice CY APR 09-11, 1991 CL DAYTON, OH SP ARMSTRONG LAB, OCCUPAT & ENVIRONM HLTH DIRECTORATE, TOXICOL DIV, NAVAL MED RES INST, TOXICOL DETACHMENT, ARMY BIOMED RES & DEV LAB, NATL RES COUNCIL COMM TOXICOL C1 UNIFORMED SERV UNIV HLTH SCI,F EDWARD HEBERT SCH MED,USA,DEPT PREVENT MED & BIOMET,BETHESDA,MD 20814. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER CONFERENCE GOVERNMENTAL INDUSTRIAL HYGIENISTS PI CINCINNATI PA 6500 GLENWAY AVE, BLDG D-7, CINCINNATI, OH 45211 BN 0-936712-90-2 PY 1992 BP 189 EP 195 PG 7 WC Public, Environmental & Occupational Health; Toxicology SC Public, Environmental & Occupational Health; Toxicology GA BC41F UT WOS:A1992BC41F00030 ER PT J AU NORTON, AR AF NORTON, AR TI BREAKING THROUGH THE WALL OF FEAR IN THE ARAB-WORLD SO CURRENT HISTORY LA English DT Article AB "Ironically, the most significant impact of the Persian Gulf war may have been...that the 'wall of fear' separating citizens from autocratic rulers has been broken through. If this is true, United States President George Bush and his colleagues in the anti-Iraq coalition may have unleashed whirlwinds of change that will engender profound instability in the Arab world. While the great powers applaud participation and exalt democracy, they loathe instability; yet the achievement of greater participation and democratization without accompanying instability is difficult to imagine." RP NORTON, AR (reprint author), US MIL ACAD,POLIT SCI,W POINT,NY 10996, USA. NR 2 TC 0 Z9 0 U1 0 U2 1 PU CURRENT HIST INC PI PHILADELPHIA PA 4225 MAIN ST PO BOX 4647, PHILADELPHIA, PA 19127 SN 0011-3530 J9 CURR HIST JI Curr. Hist. PD JAN PY 1992 VL 91 IS 561 BP 37 EP 41 PG 5 WC International Relations; Political Science SC International Relations; Government & Law GA GX063 UT WOS:A1992GX06300009 ER PT J AU SASAKAWA, C BUYSSE, JM WATANABE, H AF SASAKAWA, C BUYSSE, JM WATANABE, H TI THE LARGE VIRULENCE PLASMID OF SHIGELLA SO CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY LA English DT Review ID ENTEROINVASIVE ESCHERICHIA-COLI; CONGO RED BINDING; POSITIVE REGULATOR GENE; FORM-I PLASMID; FLEXNERI 2A; NUCLEOTIDE-SEQUENCE; HELA-CELLS; MOLECULAR-CLONING; FUNCTIONAL-ORGANIZATION; MEMBRANE-PROTEINS C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BACTERIAL IMMUNOL,WASHINGTON,DC 20307. NATL INST HLTH,DEPT BACTERIOL,SHINAGAWA KU,TOKYO 141,JAPAN. RP SASAKAWA, C (reprint author), UNIV TOKYO,INST MED SCI,DEPT BACTERIOL,MINATO KU,TOKYO 108,JAPAN. NR 80 TC 39 Z9 39 U1 1 U2 3 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0070-217X J9 CURR TOP MICROBIOL JI Curr. Top. Microbiol. Immunol. PY 1992 VL 180 BP 21 EP 44 PG 24 WC Immunology; Microbiology SC Immunology; Microbiology GA KR005 UT WOS:A1992KR00500002 PM 1505205 ER PT J AU HALE, TL KEREN, DF AF HALE, TL KEREN, DF TI PATHOGENESIS AND IMMUNOLOGY IN SHIGELLOSIS - APPLICATIONS FOR VACCINE DEVELOPMENT SO CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY LA English DT Review ID IMMUNOGLOBULIN-A RESPONSE; 2 ATTENUATING MARKERS; ESCHERICHIA-COLI K-12; IGA PLASMA-CELLS; FLEXNERI 2A; ORAL IMMUNIZATION; IMMUNE-RESPONSE; CANDIDATE STRAINS; RHESUS-MONKEYS; PEYERS PATCHES C1 WARD MED LABS,ANN ARBOR,MI 48105. RP HALE, TL (reprint author), WALTER REED ARMY INST RES,DEPT ENTER INFECT,WASHINGTON,DC 20307, USA. NR 59 TC 7 Z9 8 U1 0 U2 3 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0070-217X J9 CURR TOP MICROBIOL JI Curr. Top. Microbiol. Immunol. PY 1992 VL 180 BP 117 EP 137 PG 21 WC Immunology; Microbiology SC Immunology; Microbiology GA KR005 UT WOS:A1992KR00500006 PM 1380415 ER PT J AU LEANACOX, J LEVIN, S SURANA, R ZACKOWSKI, J SCHWARTZ, S AF LEANACOX, J LEVIN, S SURANA, R ZACKOWSKI, J SCHWARTZ, S TI UTILIZATION OF CHROMOSOME-SPECIFIC DNA LIBRARIES TO DELINEATE THE ORIGIN OF DENOVO DUPLICATIONS SO CYTOGENETICS AND CELL GENETICS LA English DT Meeting Abstract C1 UNIV MARYLAND,SCH MED,DIV HUMAN GENET,BALTIMORE,MD 21201. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIV FLORIDA,GAINESVILLE,FL 32611. NR 0 TC 0 Z9 0 U1 0 U2 0 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0301-0171 J9 CYTOGENET CELL GENET JI Cytogenet. Cell Genet. PY 1992 VL 60 IS 3-4 BP 268 EP 268 PG 1 WC Cell Biology; Genetics & Heredity SC Cell Biology; Genetics & Heredity GA JK230 UT WOS:A1992JK23000081 ER PT J AU BRONK, BV VANDEMERWE, WP STANLEY, M AF BRONK, BV VANDEMERWE, WP STANLEY, M TI INVIVO MEASURE OF AVERAGE BACTERIAL-CELL SIZE FROM A POLARIZED-LIGHT SCATTERING FUNCTION SO CYTOMETRY LA English DT Article DE LIGHT SCATTERING; BACTERIAL DIMENSIONS; CELL SIZE; POLARIZED LIGHT; MUELLER MATRIX FUNCTIONS; ANGULAR SCATTERING FUNCTION ID ESCHERICHIA-COLI AB A particular combination of elements of the Mueller matrix for scattering of polarized light given by (S-34 + S14)/(S11 + S13) = (S-34/S11)double-ended dagger is measured vs angle at a wavelength of 633 nm for randomly oriented suspensions of several species of bacteria in different stages of growth. (This combination of elements is dominated in the present measurements by the behavior of the normalized S-34 matrix element, as is indicated by the notation defined on the right side of the equation.) The resulting graph in each case shows an oscillating function of angle. This function is compressed toward smaller angles when the bacteria are in the exponential phase of growth in comparison with results for a suspension of the same bacteria in the stationary (starving-smaller cells) phase of growth. Microscopic measurements were made to determine, for each case, the average dimensions of the bacterial population. Graphs were then plotted of the peak positions from the Mueller matrix function plots vs either cell length or cell diameter. The function was shown to be strongly correlated with cell diameter under the conditions of this experiment and poorly correlated with cell length. The measurements were shown to have a sensitivity to changes in average diameter of about 20 nm. C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP BRONK, BV (reprint author), USA,CTR RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010, USA. NR 13 TC 36 Z9 38 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0196-4763 J9 CYTOMETRY JI Cytometry PY 1992 VL 13 IS 2 BP 155 EP 162 DI 10.1002/cyto.990130208 PG 8 WC Biochemical Research Methods; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA HC417 UT WOS:A1992HC41700007 PM 1547664 ER PT J AU PATTANAPANYASAT, K WEBSTER, HK UDOMSANGPETCH, R WANACHIWANAWIN, W YONGVANITCHIT, K AF PATTANAPANYASAT, K WEBSTER, HK UDOMSANGPETCH, R WANACHIWANAWIN, W YONGVANITCHIT, K TI FLOW CYTOMETRIC 2-COLOR STAINING TECHNIQUE FOR SIMULTANEOUS DETERMINATION OF HUMAN ERYTHROCYTE-MEMBRANE ANTIGEN AND INTRACELLULAR MALARIAL DNA SO CYTOMETRY LA English DT Article DE FLUORESCEIN; NUCLEIC ACID FLUOROCHROME; PLASMODIUM-FALCIPARUM; PROPIDIUM IODIDE; RED BLOOD CELL ID DECAY-ACCELERATING FACTOR; PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA; PLASMODIUM-FALCIPARUM; FACTOR DAF; RED-CELLS; IDENTIFICATION; FLUORESCENCE; PROTEIN; INVITRO; CULTURE AB A novel fixative and permeabilization method is described which allows simultaneous flow cytometric detection of red blood cell membrane antigen and intracellular malaria parasites. To illustrate the method, red blood cells from patients with paroxysmal nocturnal hemoglobinuria were infected with Plasmodium falciparum and maintained in synchronous red blood cell culture. The infected red blood cells were immunolabeled with antibodies directed to the complement regulatory protein decay-accelerating factor (DAF) followed by subsequent fixations in paraformaldehyde and then glutaraldehyde in phosphate-buffered saline. Finally, DNA of the intraerythrocytic parasites was stained with propidium iodide. Using this technique, cellular morphology was well preserved, no cell aggregation was observed, and high-quality indirect immunofluorescence and parasite DNA staining were obtained with negligible nonspecific labelling. Simultaneous measurement of parasite DNA and red blood cell membrane determinants makes possible the investigation of alterations of red cell membrane proteins in association with development of intracellular malaria parasites. C1 SIRIRAJ HOSP,FAC GRAD STUDIES,DIV HEMATOL,BANGKOK 7,THAILAND. MAHIDOL UNIV,FAC SCI,DEPT PATHOBIOL,BANGKOK 10700,THAILAND. ARMED FORCES RES INST MED SCI,DEPT IMMUNOL & BIOCHEM,BANGKOK,THAILAND. RP PATTANAPANYASAT, K (reprint author), SIRIRAJ HOSP,FAC GRAD STUDIES,CTR THALASSEMIA,BANGKOK 7,THAILAND. FU NHLBI NIH HHS [HL 34408] NR 19 TC 25 Z9 25 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0196-4763 J9 CYTOMETRY JI Cytometry PY 1992 VL 13 IS 2 BP 182 EP 187 DI 10.1002/cyto.990130212 PG 6 WC Biochemical Research Methods; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA HC417 UT WOS:A1992HC41700011 PM 1372210 ER PT J AU SMITH, KJ SKELTON, HG HOLLAND, TT AF SMITH, KJ SKELTON, HG HOLLAND, TT TI RECENT ADVANCES AND CONTROVERSIES CONCERNING ADNEXAL NEOPLASMS SO DERMATOLOGIC CLINICS LA English DT Article RP SMITH, KJ (reprint author), WALTER REED ARMY MED CTR,DIV RETROVIROL,WASHINGTON,DC 20307, USA. NR 0 TC 24 Z9 25 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0733-8635 J9 DERMATOL CLIN JI Dermatol. Clin. PD JAN PY 1992 VL 10 IS 1 BP 117 EP 160 PG 44 WC Dermatology SC Dermatology GA GX329 UT WOS:A1992GX32900008 PM 1309688 ER PT J AU SHAFFER, D WALKER, K WEISS, GR AF SHAFFER, D WALKER, K WEISS, GR TI MALIGNANT-MELANOMA IN A HISPANIC MALE WITH NEVUS OF OTA SO DERMATOLOGY LA English DT Article DE MALIGNANT MELANOMA; OCULODERMAL MELANOCYTOSIS; NEVUS OF OTA; BLADDER ID OCULODERMAL MELANOCYTOSIS; BLUE NEVUS AB Nevus of Ota is uncommon in the non-Oriental population. We report a case of malignant melanoma with metastasis to the genitourinary tract in a Hispanic male with nevus of Ota. Thirty-six prior cases of nevus of Ota with malignant melanoma reported in the English language are reviewed. Sixty-eight percent were women; 76% were Caucasians. Metastatic disease was reported in 16%. Three patients had liver metastases. Our case was the first involving the genito-urinary tract. All but one patient with metastatic disease died within 1 month of presentation. Despite the increased frequency of nevus of Ota in the Japanese, only 4 cases of malignant melanoma have been reported. Nevus of Ota would appear to be a risk factor for developing malignant melanoma in the Caucasian population. C1 UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 78284. AUDIE L MURPHY MEM VET ADM MED CTR,SAN ANTONIO,TX 78284. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. NR 44 TC 20 Z9 22 U1 0 U2 1 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1018-8665 J9 DERMATOLOGY JI Dermatology PY 1992 VL 185 IS 2 BP 146 EP 150 PG 5 WC Dermatology SC Dermatology GA JK178 UT WOS:A1992JK17800017 PM 1421629 ER PT J AU NAKAMURA, KT AYAU, EL UYEHARA, CFT EISENHAUER, CL IWAMOTO, LM LEWIS, DE AF NAKAMURA, KT AYAU, EL UYEHARA, CFT EISENHAUER, CL IWAMOTO, LM LEWIS, DE TI METHAMPHETAMINE DETECTION FROM MECONIUM AND AMNIOTIC-FLUID IN GUINEA-PIGS DEPENDS ON GESTATIONAL-AGE AND METABOLISM SO DEVELOPMENTAL PHARMACOLOGY AND THERAPEUTICS LA English DT Article DE METHAMPHETAMINE; MECONIUM; FETUS; NEWBORN; AMNIOTIC FLUID ID COCAINE USE; MATERNAL COCAINE; PREGNANCY; INFANTS AB Significant adverse perinatal effects of maternal methamphetamine use have been reported, but little is known about factors influencing methamphetamine screening test results during the perinatal period. We tested the hypothesis that gestational age would affect quantitative recovery of methamphetamine in meconium and amniotic fluid. Time-bred guinea pigs received an intraperitoneal (i.p.) injection of 1 mg/kg methamphetamine at either 44 days (0.65 of term, n = 5), 50 days (0.74, n = 8), 56 days (0.82, n = 9) or 63 days (0.93, n = 4) gestation. At 1 or 7 days after i.p. methamphetamine, meconium and amniotic fluid were collected for quantitative methamphetamine assay by gas chromatography-mass spectrometry. Recovery from amniotic fluid and meconium 1 day after injection was influenced by gestational age. Greater values in amniotic fluid and meconium and a higher percentage of positive samples were seen in older fetuses. Collectively at all gestational ages, combined testing of amniotic fluid and meconium yielded detectable methamphetamine or its metabolites in 87% of guinea pigs 1 day after injection. However, methamphetamine was not detectable 1 week after injection in any sample (n = 63) at either 0.74 or 0.82 of term except for one positive amniotic fluid sample. Finally, demethylation of methamphetamine to amphetamine was higher in older fetuses. In summary, these results suggest that in guinea pigs: (1) gestational age may be an important consideration in interpreting quantitative methamphetamine recovery in perinatal samples; (2) amniotic fluid testing may be useful as an early indicator of fetal exposure; (3) timing of sample collection affects detection rate in amniotic fluid and meconium, and (4) combined testing of amniotic fluid and meconium may increase the probability of detecting positive samples at younger gestations. C1 KAPIOLANI MED CTR WOMEN & CHILDREN,JOHN A BURNS SCH MED,DEPT PEDIAT,HONOLULU,HI. TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96859. UNITED STATES DRUG TESTING LABS,CHICAGO,IL. NR 27 TC 9 Z9 9 U1 2 U2 2 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0379-8305 J9 DEV PHARMACOL THERAP JI Dev. Pharmacol. Ther. PY 1992 VL 19 IS 4 BP 183 EP 190 PG 8 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA ML214 UT WOS:A1992ML21400003 PM 1343621 ER PT J AU KOPLOVITZ, I STEWART, JR AF KOPLOVITZ, I STEWART, JR TI EFFICACY OF OXIME PLUS ATROPINE TREATMENT AGAINST SOMAN POISONING IN THE ATROPINESTERASE-FREE RABBIT SO DRUG AND CHEMICAL TOXICOLOGY LA English DT Article ID HI-6; THERAPY; RODENTS AB The oximes pralidoxime chloride (2-PAM), MMB4, and HI-6 were evaluated in combination with atropine as treatments against soman poisoning in atropinesterase-free rabbits. Animals were challenged i.m. with 2 x LD50 soman and treated at the onset of toxic signs with 50-mu-mol/kg of oxime and 5 or 13 mg/kg atropine. Survival and time to death were compared at 48 hours post-soman challenge. Survival rates in MMB4 and HI-6 treated animals were higher than in 2-PAM-treated animals. The increase in survival was significant at the 13 mg/kg dose of atropine. MMB4 and HI-6 also significantly delayed time to death after soman compared to 2-PAM. The results suggest that MMB4 and HI-6 have potential as useful oximes for treating soman poisoning. RP KOPLOVITZ, I (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 22 TC 15 Z9 15 U1 0 U2 2 PU MARCEL DEKKER INC PI NEW YORK PA 270 MADISON AVE, NEW YORK, NY 10016 SN 0148-0545 J9 DRUG CHEM TOXICOL JI Drug Chem. Toxicol. PY 1992 VL 15 IS 2 BP 117 EP 126 DI 10.3109/01480549209032294 PG 10 WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy; Toxicology SC Chemistry; Pharmacology & Pharmacy; Toxicology GA HV756 UT WOS:A1992HV75600002 PM 1597126 ER PT J AU HARRIS, LW ANDERSON, DR PASTELAK, AM BOWERSOX, SL VANDERPOOL, BA LENNOX, WJ AF HARRIS, LW ANDERSON, DR PASTELAK, AM BOWERSOX, SL VANDERPOOL, BA LENNOX, WJ TI ACETYLCHOLINESTERASE INHIBITION AND ANTI-SOMAN EFFICACY OF HOMOLOGS OF PHYSOSTIGMINE SO DRUG AND CHEMICAL TOXICOLOGY LA English DT Article ID ORAL PHYSOSTIGMINE; ALZHEIMERS-DISEASE; PROTECTION; ATROPINE AB Inhibition of acetylcholinesterase (AChE) activity by physostigmine (PHY) is reversible due to spontaneous decarbamylation. Physostigmine has been shown to be effective as a pretreatment against potent anticholinesterase poisons (e.g., soman) in experimental animals, yet it is short acting and causes undesirable side effects in mammals. The two-fold purpose of this study was 1) to determine whether extension of the N-substituted alkyl chain (N-SAC) of PHY from N-methyl to N-ethyl (I), N-propyl (II), N-isopropyl (III), N-butyl (IV) or N-heptyl (V) affects anti-AChE potency and spontaneous decarbamylation of inhibited AChE of guinea pig blood in vitro and in vivo, and 2) to see whether chain extension affects efficacy as pretreatment in poisoning by soman. The in vitro AChE inhibition studies were done using whole blood incubated at 37-degrees-C for 30 min. All 5 homologs possessed anti-AChE activity with I50s ranging from 1.1 to 27.6 x 10(-7)M; compound III was the least potent in vitro and in vivo. Lengthening of the N-SAC of PHY markedly extended the duration of anti-AChE activity when compared to PHY, but rendered the modified compounds ineffective as pretreatments against soman. These data support the premise that the decrease in decarbamylation rates observed upon extending the N-SAC of PHY is responsible for the loss of effectiveness of pretreatment regimens against soman. Perhaps, these homologs of PHY may have potential use in instances where sustained action of acetylcholine is required at cholinergic junctions because of disease conditions or drug overdosage. RP HARRIS, LW (reprint author), USA,MED RES INST CHEM DEF,SGRD UV PA,ABERDEEN PROVING GROUND,MD 21010, USA. NR 32 TC 4 Z9 4 U1 0 U2 0 PU MARCEL DEKKER INC PI NEW YORK PA 270 MADISON AVE, NEW YORK, NY 10016 SN 0148-0545 J9 DRUG CHEM TOXICOL JI Drug Chem. Toxicol. PY 1992 VL 15 IS 2 BP 127 EP 143 DI 10.3109/01480549209032295 PG 17 WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy; Toxicology SC Chemistry; Pharmacology & Pharmacy; Toxicology GA HV756 UT WOS:A1992HV75600003 PM 1597127 ER PT J AU CAPACIO, BR HARRIS, LW ANDERSON, DR LENNOX, WJ GALES, V DAWSON, JS AF CAPACIO, BR HARRIS, LW ANDERSON, DR LENNOX, WJ GALES, V DAWSON, JS TI USE OF THE ACCELERATING ROTAROD FOR ASSESSMENT OF MOTOR-PERFORMANCE DECREMENT INDUCED BY POTENTIAL ANTICONVULSANT COMPOUNDS IN NERVE AGENT POISONING SO DRUG AND CHEMICAL TOXICOLOGY LA English DT Article ID INDUCED SEIZURE ACTIVITY; PARAOXON TOXICITY; SOMAN; DIAZEPAM; RATS; PROTECTION; PATHOLOGY; PYRIDOSTIGMINE; PRETREATMENT; CONVULSIONS AB The accelerating rotarod was used to assess motor performance decrement in rats after administration of candidate anticonvulsant compounds (acetazolamide, amitriptyline, chlordiazepoxide, diazepam, diazepam-lysine, lorazepam, loprazolam, midazolam, phenobarbital and scopolamine) against nerve agent poisoning. All compounds were tested as the commercially available injectable preparation except for diazepam-lysine and loprazolam, which are not FDA approved. A peak effect time, as well as a dose to decrease performance time by 50% from control (PDD50), was determined. The calculated PDD50 (mu-mol/kg) values and peak effect times were midazolam, 1.16 at 15 min; loprazolam, 1.17 at 15 min; diazepam-lysine, 4.17 at 30 min; lorazepam, 4.98 at 15 min; diazepam, 5.27 at 15 min; phenobarbital, 101.49 at 45 min; chlordiazepoxide, 159.21 at 30 min; scopolamine, amitriptyline and acetazolamide did not demonstrate a performance decrement at any of the doses tested. The PDD50 values were compared with doses which have been utilized against nerve agent-induced convulsions or published ED50 values from standard anticonvulsant screening tests (maximal electroshock [MES] and subcutaneous pentylenetetrazol [scMET]). The results suggest that at anticonvulsant doses against nerve agents, all the benzodiazepines and phenobarbital have the potential to cause a performance decrement, whereas candidate anticonvulsants of the non-benzodiazepine or non-barbiturate type would not be expected to demonstrate this effect on motor performance. It is concluded that compounds such as acetazolamide, amitriptyline and scopolamine offer alternatives to the highly decrementing benzodiazepines and phenobarbital and should be further tested as anticonvulsant candidates against nerve agent intoxication. RP CAPACIO, BR (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 52 TC 7 Z9 8 U1 0 U2 1 PU MARCEL DEKKER INC PI NEW YORK PA 270 MADISON AVE, NEW YORK, NY 10016 SN 0148-0545 J9 DRUG CHEM TOXICOL JI Drug Chem. Toxicol. PY 1992 VL 15 IS 3 BP 177 EP 201 DI 10.3109/01480549209014150 PG 25 WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy; Toxicology SC Chemistry; Pharmacology & Pharmacy; Toxicology GA JM276 UT WOS:A1992JM27600001 PM 1425360 ER PT J AU FILBERT, MG MOORE, DH ADLER, M AF FILBERT, MG MOORE, DH ADLER, M TI RELAXATION OF SOMAN-INDUCED CONTRACTURE OF AIRWAY SMOOTH-MUSCLE INVITRO SO DRUG AND CHEMICAL TOXICOLOGY LA English DT Article ID CANINE; ACETYLCHOLINE; ISOPROTERENOL; METHACHOLINE; ANTAGONISM; RESPONSES AB A possible role for beta-adrenergic agonists in the management of bronchoconstriction resulting from exposure to anticholinesterase compounds was investigated in vitro in canine tracheal smooth muscle. Norepinephrine, salbutamol and isoproterenol produced partial relaxation of soman-induced contractures, However, the relaxation induced was not sustained; muscle tensions returned to pretreatment levels within minutes despite the continued presence of beta-agonists. Increasing cAMP levels with the non beta-agonist bronchodilators such as theophylline, a phosphodiesterase inhibitor, or forskolin, a specific stimulator of adenylate cyclase, resulted in more complete and longer lasting relaxation, suggesting that beta-adrenoceptor desensitization may contribute to the failure by beta-agonists to produce sustained relaxation. RP FILBERT, MG (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 24 TC 1 Z9 1 U1 0 U2 0 PU MARCEL DEKKER INC PI NEW YORK PA 270 MADISON AVE, NEW YORK, NY 10016 SN 0148-0545 J9 DRUG CHEM TOXICOL JI Drug Chem. Toxicol. PY 1992 VL 15 IS 3 BP 203 EP 215 DI 10.3109/01480549209014151 PG 13 WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy; Toxicology SC Chemistry; Pharmacology & Pharmacy; Toxicology GA JM276 UT WOS:A1992JM27600002 PM 1358598 ER PT J AU LENNOX, WJ HARRIS, LW ANDERSON, DR SOLANA, RP MURROW, ML WADE, JV AF LENNOX, WJ HARRIS, LW ANDERSON, DR SOLANA, RP MURROW, ML WADE, JV TI SUCCESSFUL PRETREATMENT THERAPY OF SOMAN, SARIN AND VX INTOXICATION SO DRUG AND CHEMICAL TOXICOLOGY LA English DT Article ID IONIC CHANNEL COMPLEX; ACETYLCHOLINE; ATROPINE; PYRIDOSTIGMINE; PHYSOSTIGMINE; PROTECTION AB Chemical pretreatment is effective against a 2 LD50 challenge of soman,sarin or VX or a 5 LD50 challenge of tabun. Chemical pretreatment followed by post challenge therapy should be effective against greater levels of agent. Such tests in guinea pigs are reported here; pretreatment regimens (PRGs) consisted of physostigmine (0.15 mg/kg, im) and an adjunct. The adjuncts [mg/kg, im] used were aprophen [8], atropine (AT)[16], azaprophen (AZA)[5], benactyzine [1.25], benztropine (BT) [4], scopolamine [0.081 and trihexyphenidyl [2]. Pretreatment was given 30 min before, and atropine (16 mg/kg, im) and 2-PAM (25 mg/kg, im) therapy (T) at one min after, 5 LD50s of agent. Results indicate that, all of the PRG+T regimens, except BT-not tested with T, prevent lethality by soman; trihexyphenidyl and scopolamine (the only adjuncts used therein) regimens each prevent lethality by sarin and VX. Against soman, all PRG+T regimens (vs PRG only) may shorten the median recovery time to 2 hrs or less. Even without therapy, the PRGs containing AT, AZA or BT prevent lethality by 5 LD50s of soman; however, used alone, only the PRG containing AZA reduces the incidence of convulsions at this level of soman. RP LENNOX, WJ (reprint author), USA,MED RES INST CHEM DEF,EDGEWOOD AREA,ABERDEEN PROVING GROUND,MD 21010, USA. NR 19 TC 8 Z9 8 U1 0 U2 2 PU MARCEL DEKKER INC PI NEW YORK PA 270 MADISON AVE, NEW YORK, NY 10016 SN 0148-0545 J9 DRUG CHEM TOXICOL JI Drug Chem. Toxicol. PY 1992 VL 15 IS 4 BP 271 EP 283 DI 10.3109/01480549209014157 PG 13 WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy; Toxicology SC Chemistry; Pharmacology & Pharmacy; Toxicology GA JY762 UT WOS:A1992JY76200001 PM 1459040 ER PT J AU ANDERSON, DR HARRIS, LW WOODARD, CL LENNOX, WJ AF ANDERSON, DR HARRIS, LW WOODARD, CL LENNOX, WJ TI THE EFFECT OF PYRIDOSTIGMINE PRETREATMENT ON OXIME EFFICACY AGAINST INTOXICATION BY SOMAN OR VX IN RATS SO DRUG AND CHEMICAL TOXICOLOGY LA English DT Article ID ACETYLCHOLINESTERASE; PROTECTION; ANIMALS; 2-PAM AB This study was done to assess the effects of pyridostigmine (PYR) on a) the accumulation of labelled VX and soman within the brain, b) the therapeutic efficacy of atropine and oxime (2-PAM or Hl-6) against intoxication by VX and soman and c) oxime-induced reactivation of inhibited acetylcholinesterase (AChE). In all experiments, rats were given PYR (131 mug/kg, im; I70, dose for whole blood AChE) or vehicle 30 min prior to nerve agent. In estimating H-3-agent the accumulation in the brain or estimating blood AChE activity, sufficient soman (47 mug/kg, iv) or VX (21.3 mug/kg, iv) was given to inhibit 50% of brain AChE activity. In assessing therapeutic efficacy and oxime-induced reactivation of blood AChE, rats were pretreated with PYR, challenged with agent and treated with atropine (16 mg/kg, im) and Hl-6 or 2-PAM (100 umoles/kg, im) 30 sec post agent. Whole blood was collected by tail bleeding to monitor peripheral AChE activity at various time points before and after PYR and challenge. Pyridostigmine failed to alter covalent binding of labelled VX or soman in the brain. The 24-hr survival data showed that PYR reduced the therapeutic benefit of atropine and oxime against VX intoxication (but not soman). Protective ratios in VX-challenged rats given vehicle or PYR and treated with atropine + 2-PAM decreased slightly from 2.5 to 2.1 (p>.05), whereas with atropine + Hl-6 they decreased significantly from 3.8 to 2.4. Also, AChE reactivation by Hl-6 in VX-challenged rats was greater (p<.05) in vehicle- than in PYR-pretreated rats. Hl-6 significantly reactivated AChE activity in both pretreatment groups (PYR or vehicle) given soman. The data suggest that PYR decreases the overall recovery of inhibited AChE in VX-challenged rats given Hl-6; under the conditions used, this adverse effect decreases atropine + oxime efficacy against VX-induced lethality. RP ANDERSON, DR (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 17 TC 21 Z9 24 U1 0 U2 0 PU MARCEL DEKKER INC PI NEW YORK PA 270 MADISON AVE, NEW YORK, NY 10016 SN 0148-0545 J9 DRUG CHEM TOXICOL JI Drug Chem. Toxicol. PY 1992 VL 15 IS 4 BP 285 EP 294 DI 10.3109/01480549209014158 PG 10 WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy; Toxicology SC Chemistry; Pharmacology & Pharmacy; Toxicology GA JY762 UT WOS:A1992JY76200002 PM 1459041 ER PT J AU ELLIFRITT, DS WINE, G SPUTO, T SAMUEL, S AF ELLIFRITT, DS WINE, G SPUTO, T SAMUEL, S TI FLEXURAL STRENGTH OF WT SECTIONS SO ENGINEERING JOURNAL-AMERICAN INSTITUTE OF STEEL CONSTRUCTION INC LA English DT Article C1 USA,CORPS ENGINEERS,WASHINGTON,DC 20310. WEDGCOR MET BLDG SYST,DENVER,CO. RP ELLIFRITT, DS (reprint author), UNIV FLORIDA,DEPT CIVIL ENGN,GAINESVILLE,FL 32611, USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU AMER INST STEEL CONSTRUCTION PI CHICAGO PA ONE EAST WACKER DR, SUITE 3100, CHICAGO, IL 60601-2001 SN 0013-8029 J9 ENG J AISC JI Eng. J.-Amer. Inst. Steel Constr. PY 1992 VL 29 IS 2 BP 67 EP 74 PG 8 WC Construction & Building Technology; Engineering, Civil SC Construction & Building Technology; Engineering GA JC081 UT WOS:A1992JC08100003 ER PT J AU KENTULA, ME SIFNEOS, JC GOOD, JW RYLKO, M KUNZ, K AF KENTULA, ME SIFNEOS, JC GOOD, JW RYLKO, M KUNZ, K TI TRENDS AND PATTERNS IN SECTION 404 PERMITTING REQUIRING COMPENSATORY MITIGATION IN OREGON AND WASHINGTON, USA SO ENVIRONMENTAL MANAGEMENT LA English DT Article DE WETLANDS; CLEAN WATER ACT; MITIGATION; WETLAND CREATION; PACIFIC NORTHWEST; WASHINGTON; OREGON ID HABITAT CONSERVATION EFFORTS; UNITED-STATES; SOUTHEAST REGION AB The effects of permitting decisions made under Section 404 of the Clean Water Act for which compensatory mitigation was required were examined. Information was compiled on permits issued in Oregon (January 1977-January 1987) and Washington (1980-1986). Data on the type of project permitted, wetland impacted, and mitigation project were collected and analyzed. The records of the Portland and Seattle District Offices of the US Army Corps of Engineers and of Environmental Protection Agency Region X were the primary sources of information. The 58 permits issued during the years of concern in Oregon document impacts to 82 wetlands and the creation of 80. The total area of wetland impacted was 74 ha while 42 ha were created, resulting in a net loss of 32 ha or 43%. The 35 permits issued in Washington document impacts to 72 wetlands and the creation of 52. The total area of wetland impacted was 61 ha while 45 ha were created, resulting in a net loss of 16 ha or 26%. In both states, the number of permits requiring compensation increased with time. The area of the impacted and created wetlands tended to be less-than-or-equal-to 0.40 ha. Permitted activity occurred primarily west of the Cascade Mountains and in the vicinity of urban centers. Estuarine and palustrine wetlands were impacted and created most frequently, The wetland types created most often were not always the same as those impacted; therefore, local gains and losses of certain types occurred. In both states the greatest net loss in area was in freshwater marshes. This study illustrates how Section 404 permit data might be used in managing a regional wetland resource. However, because the data readily available were either incomplete or of poor quality, the process of gathering information was very labor intensive. Since similar analyses would be useful to resource managers and scientists from other areas, development of an up-to-date standardized data base is recommended. C1 US EPA,ENVIRONM RES LAB,MANTECH ENVIRONM TECHNOL INC,CORVALLIS,OR 97333. OREGON STATE UNIV,COLL OCEANOG,CORVALLIS,OR 97331. US EPA,SEATTLE,WA 98101. USA,CORPS ENGINEERS,ENVIRONM RESOURCES SECT BRANCH,SEATTLE,WA 98504. RP KENTULA, ME (reprint author), US EPA,ENVIRONM RES LAB,200 SW 35TH ST,CORVALLIS,OR 97333, USA. NR 13 TC 55 Z9 59 U1 2 U2 10 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0364-152X J9 ENVIRON MANAGE JI Environ. Manage. PD JAN-FEB PY 1992 VL 16 IS 1 BP 109 EP 119 DI 10.1007/BF02393913 PG 11 WC Environmental Sciences SC Environmental Sciences & Ecology GA GY818 UT WOS:A1992GY81800010 ER PT J AU KARARA, AH MCFARLAND, VA AF KARARA, AH MCFARLAND, VA TI A PHARMACOKINETIC ANALYSIS OF THE UPTAKE OF POLYCHLORINATED-BIPHENYLS (PCBS) BY GOLDEN SHINERS SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE PCB; KINETICS; RATE-LIMITING; BIOCONCENTRATION; CLEARANCE ID DI-2-ETHYLHEXYL PHTHALATE DEHP; HYDROPHOBIC CHEMICALS; SHEEPSHEAD MINNOW; RAINBOW-TROUT; FISH GILLS; BIOCONCENTRATION; ACCUMULATION; MODEL; ELIMINATION; TEMPERATURE AB A 96-h, static, nonconstant exposure design was used to assess pharmacokinetic parameters and to identify the rate-limiting process in polychlorinated biphenyl (PCB) uptake by golden shiners (Notemigonus crysoleucas). Fish were exposed individually to C-14-labeled PCBs corresponding to Aroclor 1254 (A1254). After various intervals (2-96 h), fish and water were analyzed for total radioactivity. Uptake of PCBs and decline of the external water concentration were both rapid. A clearance constant-based one-compartment model was used to represent the fish. Model-based equations for PCB concentrations in the fish and in the water were fitted simultaneously to the observed data with the PCNONLIN(TM) computer program. The absorption clearance constant was 30.8 ml.h-1.g-1 fish, which identified gill blood flow as the uptake rate-controlling process. The model-predicted apparent volume of distribution, V(d), and bioconcentration factor, K(b), were 5,280 ml/g fish and 9,059 ml water per gram fish, respectively. The model-predicted elimination rate constant, k(e), was 5.84 x 10(-3) h-1, corresponding to a t1/2 of 4.9 d. C1 USA,ENVIRONM LAB,ENGINEER WATERWAYS EXPT STN,VICKSBURG,MS 39180. NE LOUISIANA UNIV,SCH PHARM,DIV PHARMACEUT & MED CHEM,MONROE,LA 71209. NR 27 TC 4 Z9 4 U1 1 U2 6 PU SETAC PRESS PI PENSACOLA PA 1010 NORTH 12TH AVE, PENSACOLA, FL 32501-3370 SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PY 1992 VL 11 IS 3 BP 315 EP 320 DI 10.1897/1552-8618(1992)11[315:APAOTU]2.0.CO;2 PG 6 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA HF759 UT WOS:A1992HF75900005 ER PT J AU VAUGHN, DW HOKE, CH AF VAUGHN, DW HOKE, CH TI THE EPIDEMIOLOGY OF JAPANESE ENCEPHALITIS - PROSPECTS FOR PREVENTION SO EPIDEMIOLOGIC REVIEWS LA English DT Review ID LINKED IMMUNOSORBENT-ASSAY; OLIGONUCLEOTIDE FINGERPRINT ANALYSIS; CULEX-TRITAENIORHYNCHUS MOSQUITOS; MONOCLONAL-ANTIBODIES; CEREBROSPINAL-FLUID; VERTICAL TRANSMISSION; HEMAGGLUTINATION TEST; NUCLEOTIDE-SEQUENCE; ATTENUATED VACCINE; MANDYA DISTRICT C1 WALTER REED ARMY INST RES,DEPT VIRUS DIS,WASHINGTON,DC 20307. NR 222 TC 223 Z9 241 U1 0 U2 13 PU JOHNS HOPKINS UNIV SCHOOL HYGIENE PUB HEALTH PI BALTIMORE PA 111 MARKET PLACE, STE 840, BALTIMORE, MD 21202-6709 SN 0193-936X J9 EPIDEMIOL REV JI Epidemiol. Rev. PY 1992 VL 14 BP 197 EP 221 PG 25 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA KF390 UT WOS:A1992KF39000010 PM 1337744 ER PT J AU MEYERHOFF, JL CARTER, RE YOURICK, DL SLUSHER, BS COYLE, JT MOSHE, SL FISHER, RS AF MEYERHOFF, JL CARTER, RE YOURICK, DL SLUSHER, BS COYLE, JT MOSHE, SL FISHER, RS TI ACTIVITY OF A NAAG-HYDROLYZING ENZYME IN BRAIN MAY AFFECT SEIZURE SUSCEPTIBILITY IN GENETICALLY EPILEPSY-PRONE RATS SO EPILEPSY RESEARCH LA English DT Article; Proceedings Paper CT WORKSHOP ON MOLECULAR NEUROBIOLOGY OF EPILEPSY CY OCT, 1991 CL SALVADOR, BRAZIL SP INT LEAGUE AGAINST EPILEPSY ID ACETYL-ASPARTYL-GLUTAMATE; ACIDIC DIPEPTIDASE ACTIVITY; N-ACETYLASPARTYLGLUTAMATE IMMUNOREACTIVITY; CENTRAL NERVOUS-SYSTEM; PIG CEREBELLAR SLICES; AMINO-ACIDS; INFERIOR COLLICULUS; EVOKED RELEASE; AUDIOGENIC-SEIZURES; OLFACTORY-BULB C1 JOHNS HOPKINS UNIV,SCH MED,DEPT PHARMACOL & MOLEC SCI,BALTIMORE,MD 21205. ICI AMER INC,DEPT CNS PHARMACOL,WILMINGTON,DE 19899. HARVARD UNIV,SCH MED,DEPT PSYCHIAT,BOSTON,MA 02115. YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT NEUROL,BRONX,NY 10461. YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT NEUROSCI,BRONX,NY 10461. YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT PEDIAT,BRONX,NY 10461. JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL,BALTIMORE,MD 21205. BARROW NEUROL INST,DEPT NEUROL,PHOENIX,AZ. RP MEYERHOFF, JL (reprint author), WALTER REED ARMY INST RES,DEPT MED NEUROSCI,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307, USA. NR 101 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0920-1211 J9 EPILEPSY RES JI Epilepsy Res. PY 1992 SU 9 BP 163 EP 172 PG 10 WC Clinical Neurology SC Neurosciences & Neurology GA KH381 UT WOS:A1992KH38100017 ER PT J AU VEZZANI, A BENDOTTI, C RUIZ, R RIZZI, M MONNO, A BARRIOS, M SAMANIN, R WASTERLAIN, CG TOBIN, AJ BUZSAKI, G MEYERHOFF, JL MODY, I AF VEZZANI, A BENDOTTI, C RUIZ, R RIZZI, M MONNO, A BARRIOS, M SAMANIN, R WASTERLAIN, CG TOBIN, AJ BUZSAKI, G MEYERHOFF, JL MODY, I TI BIOCHEMICAL AND FUNCTIONAL-STUDIES ON NORADRENERGIC AND PEPTIDERGIC NEUROTRANSMISSION IN HIPPOCAMPAL KINDLING SO EPILEPSY RESEARCH LA English DT Article ID LONG-TERM POTENTIATION; TEMPORAL-LOBE EPILEPSY; AMINO-ACID ANTAGONISTS; RAT DENTATE GYRUS; NEUROPEPTIDE-Y; QUINOLINIC ACID; NMDA RECEPTORS; ASPARTATE; NOREPINEPHRINE; SOMATOSTATIN C1 RUTGERS STATE UNIV, AIDEKMAN RES CTR, CTR MOLEC & BEHAV NEUROSCI, NEW BRUNSWICK, NJ 08903 USA. WALTER REED ARMY INST RES, DEPT MED NEUROSCI, DIV NEUROPSYCHIAT, WASHINGTON, DC 20307 USA. STANFORD UNIV, MED CTR, SCH MED, DEPT NEUROL & NEUROSURG, STANFORD, CA 94305 USA. UNIV CALIF LOS ANGELES, SCH MED, DEPT NEUROL, LOS ANGELES, CA USA. UNIV CALIF LOS ANGELES, SCH MED, BRAIN RES INST, LOS ANGELES, CA USA. RP VEZZANI, A (reprint author), MARIO NEGRI INST PHARMACOL RES, NEUROPHARMACOL LAB, VIA ERITREA 62, I-20157 MILAN, ITALY. NR 53 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0920-1211 J9 EPILEPSY RES JI Epilepsy Res. PY 1992 SU 9 BP 285 EP 295 PG 11 WC Clinical Neurology SC Neurosciences & Neurology GA KH381 UT WOS:A1992KH38100029 ER PT J AU MEYERHOFF, JL ROBINSON, MB KOLLER, KJ BIXLER, MA JONES, RSG COYLE, JT AF MEYERHOFF, JL ROBINSON, MB KOLLER, KJ BIXLER, MA JONES, RSG COYLE, JT TI KINDLING INCREASES BRAIN LEVELS OF NAAG AND SEIZURES REDUCE ACTIVITY OF A NAAG-HYDROLYZING ENZYME, NAALADASE SO EPILEPSY RESEARCH LA English DT Article ID ACETYL-ASPARTYL-GLUTAMATE; ACIDIC DIPEPTIDASE ACTIVITY; RAT-BRAIN; ENTORHINAL CORTEX; HIGH-AFFINITY; AMYGDALA; PROJECTIONS; ASPARTYLGLUTAMATE; STIMULATION; ANTAGONISTS C1 AFFYMAX RES INST,PALO ALTO,CA 94304. UNIV OXFORD,DEPT PHARMACOL,OXFORD OX1 3QT,ENGLAND. CHILDRENS HOSP,DEPT NEUROSCI,PHILADELPHIA,PA 19104. HARVARD UNIV,SCH MED,DEPT PSYCHIAT,BELMONT,MA 02178. RP MEYERHOFF, JL (reprint author), WALTER REED ARMY INST RES,DEPT MED NEUROSCI,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307, USA. NR 49 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0920-1211 J9 EPILEPSY RES JI Epilepsy Res. PY 1992 SU 8 BP 297 EP 305 PG 9 WC Clinical Neurology SC Neurosciences & Neurology GA KA434 UT WOS:A1992KA43400039 ER PT J AU FISHER, RS MAYBERG, HS FROST, JJ ENGEL, J GALE, K MEYERHOFF, JL AVANZINI, G AF FISHER, RS MAYBERG, HS FROST, JJ ENGEL, J GALE, K MEYERHOFF, JL AVANZINI, G TI NEURORECEPTORS AND GLUCOSE-METABOLISM IN EPILEPSY AS STUDIED BY PET SCANNING SO EPILEPSY RESEARCH LA English DT Article; Proceedings Paper CT WORKSHOP ON MOLECULAR NEUROBIOLOGY OF EPILEPSY CY OCT, 1991 CL SALVADOR, BRAZIL SP INT LEAGUE AGAINST EPILEPSY ID POSITRON EMISSION TOMOGRAPHY; TEMPORAL-LOBE EPILEPSY; COMPLEX PARTIAL SEIZURES; MU-OPIATE RECEPTORS; HUMAN-BRAIN; BENZODIAZEPINE RECEPTORS; SURGICAL-TREATMENT; ANIMAL-MODELS; MORPHINE; BINDING C1 JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL,BALTIMORE,MD 21205. JOHNS HOPKINS UNIV,SCH MED,DEPT RADIOL,DIV NUCL MED,BALTIMORE,MD 21205. BARROW NEUROL INST,DEPT NEUROL,PHOENIX,AZ. UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 78284. UNIV CALIF LOS ANGELES,SCH MED,DEPT NEUROL,LOS ANGELES,CA 90024. UNIV CALIF LOS ANGELES,SCH MED,DEPT ANAT & CELL BIOL,LOS ANGELES,CA 90024. UNIV CALIF LOS ANGELES,SCH MED,BRAIN RES INST,LOS ANGELES,CA 90024. GEORGETOWN UNIV,MED CTR,DEPT PHARMACOL,WASHINGTON,DC 20007. WALTER REED ARMY INST RES,DEPT MED NEUROSCI,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307. NR 72 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0920-1211 J9 EPILEPSY RES JI Epilepsy Res. PY 1992 SU 9 BP 351 EP 360 PG 10 WC Clinical Neurology SC Neurosciences & Neurology GA KH381 UT WOS:A1992KH38100036 ER PT J AU PARK, OC GITTELMAN, SS AF PARK, OC GITTELMAN, SS TI SELECTIVE USE OF ANIMATION AND FEEDBACK IN COMPUTER-BASED INSTRUCTION SO ETR&D-EDUCATIONAL TECHNOLOGY RESEARCH AND DEVELOPMENT LA English DT Article ID GRAPHICS; LESSON; MODEL AB The effects of two computer-based instructional strategies-visual display and feedback type-were investigated in the acquisition of electronic troubleshooting skills. Animation was used to simulate the functional behaviors of electronic circuits and to demonstrate the troubleshooting procedures. The first hypothesis tested was that animated visual displays would be more effective than static visual displays if animation was selectively used to support the specific learning requirements of a given task. Results supported this hypothesis by showing that college students in the animated visual display condition needed significantly fewer trials than those in the static visual display condition. The second hypothesis was that the effectiveness of intentionally mediated feedback (knowledge of results or explanatory information) would be minimal if natural feedback-the system's automatic functional reaction to external inputs-was available and the subject had the basic knowledge needed to understand the system functions. The results supported this hypothesis. Overall, this study implies that instructional strategies, including visual displays and feedback, should be applied selectively based on the specific learning requirements of a given task. C1 GEORGE MASON UNIV,FAIRFAX,VA 22030. RP PARK, OC (reprint author), USA,RES INST,ALEXANDRIA,VA, USA. NR 36 TC 43 Z9 43 U1 1 U2 2 PU ASSOC EDUC COMMUNICATIONS & TECHNOLOGY PI WASHINGTON PA 1025 VERMONT AVE NW, SUITE 820, WASHINGTON, DC 20005 SN 1042-1629 J9 ETR&D-EDUC TECH RES JI ETR&D-Educ. Tech. Res. Dev. PY 1992 VL 40 IS 4 BP 27 EP 38 DI 10.1007/BF02296897 PG 12 WC Education & Educational Research SC Education & Educational Research GA KJ226 UT WOS:A1992KJ22600003 ER PT J AU LOCATIS, C PARK, OC AF LOCATIS, C PARK, OC TI SOME UNEASY INQUIRIES INTO ID EXPERT SYSTEMS SO ETR&D-EDUCATIONAL TECHNOLOGY RESEARCH AND DEVELOPMENT LA English DT Article ID AUTHORING SYSTEMS; DESIGN AB Alternative approaches to developing software automating instructional development are described in this article. Information management and expert system approaches are compared. General assumptions underlying the development of all authoring tools, including conventional authoring systems, and additional assumptions underlying the development of expert ID tools are identified. Questions are raised concerning the viability of ID automation tools. It is argued that conventional authoring systems may not be as inadequate or inferior as ID expert system developers have claimed, and that of two approaches to ID automation, tools emphasizing information management are probably most useful. Information management tools, however, still may be inappropriate in some contexts. C1 USA,RES INST,TRAINING RES LAB,ALEXANDRIA,VA. RP LOCATIS, C (reprint author), NATL LIB MED,CTR BIOMED COMMUN,BETHESDA,MD 20209, USA. NR 48 TC 2 Z9 2 U1 0 U2 0 PU ASSOC EDUC COMMUNICATIONS & TECHNOLOGY PI WASHINGTON PA 1025 VERMONT AVE NW, SUITE 820, WASHINGTON, DC 20005 SN 1042-1629 J9 ETR&D-EDUC TECH RES JI ETR&D-Educ. Tech. Res. Dev. PY 1992 VL 40 IS 3 BP 87 EP 94 DI 10.1007/BF02296845 PG 8 WC Education & Educational Research SC Education & Educational Research GA KU347 UT WOS:A1992KU34700007 ER PT J AU WRIGHT, DG LUCAS, DL KNIGHT, RD LARUSSA, VF KESSLER, SW CUTTING, MA BEDNAREK, JM AF WRIGHT, DG LUCAS, DL KNIGHT, RD LARUSSA, VF KESSLER, SW CUTTING, MA BEDNAREK, JM TI METABOLIC EVENTS THAT PROMOTE THE TERMINAL MATURATION OF HEMATOPOIETIC PROGENITOR CELLS SO EXPERIMENTAL HEMATOLOGY LA English DT Meeting Abstract ID INOSINE MONOPHOSPHATE DEHYDROGENASE; ERYTHROID-DIFFERENTIATION; LEUKEMIA-CELLS; INHIBITORS; INDUCTION; HL-60; LINE C1 WALTER REED ARMY MED CTR,DEPT HEMATOL,WASHINGTON,DC 20307. USN,MED RES INST,BETHESDA,MD. NR 11 TC 2 Z9 2 U1 0 U2 0 PU CARDEN JENNINGS PUBL CO LTD PI CHARLOTTESVILLE PA BLAKE CTR, STE 200, 1224 W MAIN ST, CHARLOTTESVILLE, VA 22903 SN 0301-472X J9 EXP HEMATOL JI Exp. Hematol. PD JAN PY 1992 VL 20 IS 1 BP 141 EP 142 PG 2 WC Hematology; Medicine, Research & Experimental SC Hematology; Research & Experimental Medicine GA GX273 UT WOS:A1992GX27300100 ER PT J AU HAUGLAND, RP YOU, WM WELLS, S DUBOSE, D AF HAUGLAND, RP YOU, WM WELLS, S DUBOSE, D TI SIMULTANEOUS VISUALIZATION OF G-ACTIN AND F-ACTIN IN ENDOTHELIAL-CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 MOLEC PROBES INC,EUGENE,OR. USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD JAN 1 PY 1992 VL 6 IS 1 BP A438 EP A438 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA GY440 UT WOS:A1992GY44002508 ER PT J AU SHERIDAN, RE AF SHERIDAN, RE TI SODIUM-CHANNEL CHARACTERIZATION IN THE HCN-1A HUMAN CORTICAL CELL-LINE SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,NEUROTOXICOL BRANCH,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD JAN 1 PY 1992 VL 6 IS 1 BP A107 EP A107 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA GY440 UT WOS:A1992GY44000620 ER PT J AU SMITH, JD GORDON, RK BRUGH, SA CHIANG, PK AF SMITH, JD GORDON, RK BRUGH, SA CHIANG, PK TI EFFECT OF 2-AMINOETHYLPHOSPHONATE ON THE INSULIN-INDUCED DIFFERENTIATION OF 3T3-L1 FIBROBLASTS INTO ADIPOCYTES SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV MASSACHUSETTS,DARTMOUTH,MA 02747. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD JAN 1 PY 1992 VL 6 IS 1 BP A494 EP A494 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA GY440 UT WOS:A1992GY44002840 ER PT J AU ZIZI, M FISHER, RS GRILLO, FG AF ZIZI, M FISHER, RS GRILLO, FG TI EFFECTS OF LIPID-COMPOSITION ON BREFELDIN A CHANNELS IN PLANAR LIPID BILAYERS SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD JAN 1 PY 1992 VL 6 IS 1 BP A230 EP A230 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA GY440 UT WOS:A1992GY44001318 ER PT J AU VEZZOLI, GC CRAVER, F CHEN, MF STANLEY, W AF VEZZOLI, GC CRAVER, F CHEN, MF STANLEY, W TI THE PROPERTIES OF HIGH-T(C) SUPERCONDUCTING MATERIALS THAT RELATE TO CHARACTERISTICS OF MARGINAL FERROELECTRICS - INTERNAL PERTURBATION LOCAL FIELD CALCULATIONS AND RELATIONSHIP TO MECHANISM SO FERROELECTRICS LA English DT Article ID HIGH-TC SUPERCONDUCTORS; O COMPOUND SYSTEM; PRESSURE AB High-T(c) superconducting oxides are composed of structural elementary building blocks including pyramids, planes, and chains in such a manner so as to create a large internal local electric perturbation field. In addition, the presence of d9 Cu2+ creates a Jahn-Teller distortion affecting the position of the apical oxygen (04) ions. Observations have also been reported of spontaneous polarization, piezoelectricity, pyroelectricity, and circular dichroism in this class of materials. These structural and property criteria suggest that high-T(c) Perovskite-like superconductors in their normal state may be in the microscopic domain a special case of marginal ferroelectric materials. The importance of ferroelectric polarization in the pre-transition normal state relates to a number of phenomena which are reported to be associated with the high-T(c) mechanism such as phonons, polarons, and charge transfer excitations. The unique structure of the Y1Ba2Cu3O7-delta gives rise to local perturbation electric fields which are calculated by a multicell point charge computer code herein described. The resonant charge transfer excitation establishes a virtual exciton which creates electron-electron coupling in the form of Cooper pairs. C1 MAINSTREAM SOFTWARE,WALTHAM,MA. RP VEZZOLI, GC (reprint author), USA,MAT TECHNOL LAB,CERAM RES BRANCH,WATERTOWN,MA 02172, USA. NR 30 TC 1 Z9 1 U1 0 U2 0 PU GORDON BREACH SCI PUBL LTD PI READING PA C/O STBS LTD PO BOX 90, READING, BERKS, ENGLAND RG1 8JL SN 0015-0193 J9 FERROELECTRICS PY 1992 VL 130 IS 1-3 BP 215 EP 244 PG 30 WC Materials Science, Multidisciplinary; Physics, Condensed Matter SC Materials Science; Physics GA JV426 UT WOS:A1992JV42600019 ER PT B AU DOWLING, JP AF DOWLING, JP BE Black, TD Nieto, MM Pilloff, HS Scully, MO Sinclair, RM TI CLASSICAL VERSUS QUANTUM EFFECTS IN CAVITY QED SO FOUNDATIONS OF QUANTUM MECHANICS LA English DT Proceedings Paper CT WORKSHOP ON THE FOUNDATIONS OF QUANTUM MECHANICS CY MAY 27-31, 1991 CL ST JOHNS COLL, SANTA FE, NM SP USN, OFF NAVAL RES, LOS ALAMOS NATL LAB, UNIV NEW MEXICO HO ST JOHNS COLL C1 USA, MISSILE COMMAND, WEAP SCI DIRECTORATE, AMSMI RD WS, REDSTONE ARSENAL, AL 35898 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE BN 981-02-0980-0 PY 1992 BP 284 EP 297 PG 14 WC Optics; Physics, Multidisciplinary SC Optics; Physics GA BW53X UT WOS:A1992BW53X00034 ER PT B AU BOWDEN, CM ENGLUND, JC AF BOWDEN, CM ENGLUND, JC BE Black, TD Nieto, MM Pilloff, HS Scully, MO Sinclair, RM TI SPECTRAL AND ENERGY FLUCTUATIONS OF THE SPONTANEOUSLY GENERATED STOKES FIELD IN STIMULATED RAMAN-SCATTERING SO FOUNDATIONS OF QUANTUM MECHANICS LA English DT Proceedings Paper CT WORKSHOP ON THE FOUNDATIONS OF QUANTUM MECHANICS CY MAY 27-31, 1991 CL ST JOHNS COLL, SANTA FE, NM SP USN, OFF NAVAL RES, LOS ALAMOS NATL LAB, UNIV NEW MEXICO HO ST JOHNS COLL C1 USA, MISSILE COMMAND, CTR RES DEV & ENGN, WEAP SCI DIRECTORATE, REDSTONE ARSENAL, AL 35898 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE BN 981-02-0980-0 PY 1992 BP 326 EP 334 PG 9 WC Optics; Physics, Multidisciplinary SC Optics; Physics GA BW53X UT WOS:A1992BW53X00038 ER PT J AU KOPLOVITZ, I HARRIS, LW ANDERSON, DR LENNOX, WJ STEWART, JR AF KOPLOVITZ, I HARRIS, LW ANDERSON, DR LENNOX, WJ STEWART, JR TI REDUCTION BY PYRIDOSTIGMINE PRETREATMENT OF THE EFFICACY OF ATROPINE AND 2-PAM TREATMENT OF SARIN AND VX POISONING IN RODENTS SO FUNDAMENTAL AND APPLIED TOXICOLOGY LA English DT Article ID SOMAN; REACTIVATION; PROTECTION; ANIMALS; PAM-2 RP KOPLOVITZ, I (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 21 TC 35 Z9 36 U1 0 U2 6 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0272-0590 J9 FUND APPL TOXICOL JI Fundam. Appl. Toxicol. PD JAN PY 1992 VL 18 IS 1 BP 102 EP 106 DI 10.1016/0272-0590(92)90201-R PG 5 WC Toxicology SC Toxicology GA HB794 UT WOS:A1992HB79400013 PM 1601200 ER PT B AU KEEHAN, KR SISK, WE AF KEEHAN, KR SISK, WE BE Akin, C Markuszewski, R Smith, J TI COMPOSTING OF EXPLOSIVES-CONTAMINATED SOILS AT A NATIONAL PRIORITY LIST SITE SO GAS, OIL, AND ENVIRONMENTAL BIOTECHNOLOGY IV LA English DT Proceedings Paper CT 4th International Symposium on Gas, Oil, and Environmental Biotechnology CY DEC 09-11, 1991 CL COLORADO SPRINGS, CO SP GAS RES INST C1 USA,TOXIC HAZARDOUS MAT AGCY,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INST GAS TECHNOLOGY PI DES PLAINES PA 1700 S. MT. PROSPECT RD, DES PLAINES, IL 60018 BN 0-910091-85-4 PY 1992 BP 227 EP 237 PG 11 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA BZ54J UT WOS:A1992BZ54J00012 ER PT J AU MONAHAN, DW PELUSO, FE GOLDNER, F AF MONAHAN, DW PELUSO, FE GOLDNER, F TI COMBUSTIBLE COLONIC GAS LEVELS DURING FLEXIBLE SIGMOIDOSCOPY AND COLONOSCOPY SO GASTROINTESTINAL ENDOSCOPY LA English DT Article ID BOWEL PREPARATION; LAVAGE SOLUTION; POLYETHYLENE-GLYCOL; CLEANSING METHODS; EXPLOSION; HYDROGEN; POLYPECTOMY AB To what extent the standard preparation for sigmoidoscopy (phosphosoda enemas) makes the bowel safe for electrocautery is unknown. Sixty patients were prospectively evaluated to compare the presence of the combustible gases hydrogen and methane during colonoscopy and flexible sigmoidoscopy. Thirty patients underwent flexible sigmoidoscopy after phosphosoda enema preparation, and 30 patients underwent colonoscopy after a polyethylene glycol solution preparation. During colonoscopy, the concentrations of hydrogen and methane remained below combustible levels in all patients. Even segments of colon with significant fecal matter present did not have combustible levels of these two gases. However, at flexible sigmoidoscopy, combustible levels of hydrogen and methane were measured in 3 of 30 (10%) patients. Due to the risk of explosion, electrocautery should not be performed during routine flexible sigmoidoscopy after the standard phosphosoda enema preparation. C1 BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,FT SMITH,AR. BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,FT SAM HOUSTON,TX 78234. NR 28 TC 27 Z9 31 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD JAN-FEB PY 1992 VL 38 IS 1 BP 40 EP 43 DI 10.1016/S0016-5107(92)70328-9 PG 4 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA HC767 UT WOS:A1992HC76700008 PM 1612377 ER PT J AU KEATE, RF CANALES, L STARNES, EC AF KEATE, RF CANALES, L STARNES, EC TI AQUATOSIS-COLI AFTER IRRIGATION WITH A HEATER PROBE CATHETER SO GASTROINTESTINAL ENDOSCOPY LA English DT Letter RP KEATE, RF (reprint author), BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,FT SAM HOUSTON,TX 78234, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD JAN-FEB PY 1992 VL 38 IS 1 BP 98 EP 99 DI 10.1016/S0016-5107(92)70357-5 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA HC767 UT WOS:A1992HC76700036 PM 1612400 ER PT J AU SCHARF, BA FRICKE, RF BASKIN, SI AF SCHARF, BA FRICKE, RF BASKIN, SI TI COMPARISON OF METHEMOGLOBIN FORMERS IN PROTECTION AGAINST THE TOXIC EFFECTS OF CYANIDE SO GENERAL PHARMACOLOGY LA English DT Article ID PARA-AMINOPROPIOPHENONE PAPP; SODIUM-NITRITE; ANTIDOTE; BLOOD AB 1. Certain compounds that oxidize hemoglobin to methemoglobin (MHb) also protect against cyanide. 2. Evidence presented here suggests that other mechanisms may be involved. 3. Male Swiss ICR mice were pretreated intraperitoneally (i.p.) with various doses of primaquine phosphate (primaquine), WR6026 (6-methoxy-8-(6-diethylamino-hexylamino) lepidine dihydrochloride), WR238605 (8-[(4-amino-1-methylbutyl)amino]-2,6-dimethoxy-4-methyl-5-(3-trifluoromethylphenoxy) quinoline succinate), p-aminooctoyl-phenone (PAOP), or p-aminopropiophenone (PAPP). 4. The compounds were administered 15 or 60 min before an intramuscular (i.m.) challenge with a 2 x LD50 dose (5.0-5.6 mg/kg) of sodium cyanide (NaCN). 5. Twenty-four hr mortality was assessed and survivors were tested for motor incapacitation. 6. Primaquine, PAPP and PAOP increased survival compared to untreated controls, while the other MHb formers were not effective (P < 0.05). 7. PAOP is believed to form sufficient MHb only after 3 to 4 hr after administration; however it was found to be effective when administered 15 min before NaCN challenge in this study. 8. This suggests that MHb formation may not be the only factor responsible for PAOP's anti-cyanide efficacy. C1 USA,MED RES INST CHEM DEF,DIV DRUG ASSESSMENT,ABERDEEN PROVING GROUND,MD 21010. USA,MED RES INST CHEM DEF,DIV PHARMACOL,ABERDEEN PROVING GROUND,MD 21010. NR 47 TC 7 Z9 7 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0306-3623 J9 GEN PHARMACOL JI Gen. Pharmacol. PD JAN PY 1992 VL 23 IS 1 BP 19 EP 25 DI 10.1016/0306-3623(92)90041-H PG 7 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA GY392 UT WOS:A1992GY39200004 PM 1592224 ER PT J AU MALEVSKY, AV YUEN, DA AF MALEVSKY, AV YUEN, DA TI STRONGLY CHAOTIC NON-NEWTONIAN MANTLE CONVECTION SO GEOPHYSICAL AND ASTROPHYSICAL FLUID DYNAMICS LA English DT Article DE NONLINEAR RHEOLOGY; HARD TURBULENCE; MANTLE CONVECTION ID TIME-DEPENDENT CONVECTION; INFINITE PRANDTL NUMBER; THERMAL-CONVECTION; TURBULENCE; VISCOSITY; RHEOLOGY; OLIVINE AB We have studied the problem of strongly time-dependent, two-dimensional, incompressible, infinite Prandtl number thermal convection in an aspect-ratio five box for a non-Newtonian power-law rheology and a heated from below configuration, as applied to mantle dynamics. The convection equations are solved by means of a characteristics-based method with a Lagrangian formulation of the total derivative in the energy equation. Iterations are required al each time step for solving the nonlinear momentum equation. Bicubic splines are used for the spatial discretization. The transition from mildly time-dependent to the strongly chaotic or turbulent regime, in which the plumes become disconnected, occurs at much lower Nusselt numbers (Nu), between 20 and 25, than for Newtonian rheology, The Nu versus Rayleigh number (Ra) relationship displays a kink at this transition. Rising non-Newtonian plumes exhibit much greater curvature in their ascent than Newtonian ones and are strongly attracted by descending currents at the top. The viscosity field becomes strongly mixed and assumes a granular character in the turbulent regime. Horizontal spectral decomposition of the viscosity field outside the boundary layer shows that in the chaotic regime the fluctuations about the mean viscosity do not vary by more than an order of magnitude for one and a half decade in horizontal wavenumber. Vorticity fields produced by non-Newtonian convection are much more intense than Newtonian. Increasing the power law index sharpens the chaotic behavior of the flow with high Ra. C1 UNIV MINNESOTA,DEPT GEOL & GEOPHYS,MINNEAPOLIS,MN 55455. RP MALEVSKY, AV (reprint author), UNIV MINNESOTA,MINNESOTA SUPERCOMP INST,ARMY HIGH PERFORMANCE COMP & RES CTR,MINNEAPOLIS,MN 55455, USA. NR 19 TC 30 Z9 30 U1 0 U2 5 PU GORDON BREACH SCI PUBL LTD PI READING PA C/O STBS LTD PO BOX 90, READING, BERKS, ENGLAND RG1 8JL SN 0309-1929 J9 GEOPHYS ASTRO FLUID JI Geophys. Astrophys. Fluid Dyn. PY 1992 VL 65 IS 1-4 BP 149 EP 171 DI 10.1080/03091929208225244 PG 23 WC Astronomy & Astrophysics; Geochemistry & Geophysics; Mechanics SC Astronomy & Astrophysics; Geochemistry & Geophysics; Mechanics GA ME876 UT WOS:A1992ME87600008 ER PT J AU WITTEN, A GILLETTE, DD SYPNIEWSKI, J KING, WC AF WITTEN, A GILLETTE, DD SYPNIEWSKI, J KING, WC TI GEOPHYSICAL DIFFRACTION TOMOGRAPHY AT A DINOSAUR SITE SO GEOPHYSICS LA English DT Article ID PROPAGATION AB In 1979 two hikers discovered the partially exposed bones from the tail of a dinosaur in the high desert of New Mexico. Excavation in 1985 led to the recognition that the dinosaur, informally named "Seismosaurus," was new to science. It is by far the longest dinosaur on record. Excavations continued in 1986 with the discovery that additional bones leading forward from the middle region of the tail, potentially toward the remainder of the skeleton, remained entombed in the 145 million year old sandstone. The site has been the subject of intensive experimentation to assess the feasibility of geophysical remote sensing in exploration paleontology. The efforts of numerous investigators at the site may serve to change the century-old methods of hammer and chisel, in part, to those based on more modern technology. One of the methods tested is geophysical diffraction tomography (GDT). Unlike the more common straight-ray algorithms of geophysical tomography that map subsurface properties by projecting received signal amplitude or time of the first signal arrival back to the source, GDT treats the problem as one of wave propagation by inverting the linearized wave equation to compute the spatial distribution of refractive index. Excavation of the "Seismosaurus" skeleton continues. The purpose of our most recent GDT study is to further test the method and to guide paleontologists in their future excavations by locating and identifying the buried skeletal remains. A total of eleven imaged vertical cross-sections displayed features of sufficient acoustic contrast to be tentatively identified as dinosaur bone. Although the GDT resolution is insufficient to characterize bone shape, bone identification was subjectively accomplished on the basis of size, aspect ratio, and position. Based on this interpretation, it is believed that much of the remaining skeleton exists and is in near articulation. C1 WAYNE STATE UNIV,DIV ENGN TECHNOL,DETROIT,MI 48202. USA,ENVIRONM HYG ACTIV W,AURORA,CO 80045. DIV STATE HIST,SALT LAKE CITY,UT 84101. SW PALEONTOL FDN,ALBUQUERQUE,NM 87106. RP WITTEN, A (reprint author), OAK RIDGE NATL LAB,DIV ENERGY,OAK RIDGE,TN 37831, USA. NR 17 TC 12 Z9 13 U1 0 U2 2 PU SOC EXPLORATION GEOPHYSICISTS PI TULSA PA 8801 S YALE ST, TULSA, OK 74137 SN 0016-8033 J9 GEOPHYSICS JI Geophysics PD JAN PY 1992 VL 57 IS 1 BP 187 EP 195 DI 10.1190/1.1443183 PG 9 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA GY588 UT WOS:A1992GY58800019 ER PT J AU GIBSON, T AF GIBSON, T TI DEVELOPING A COMMAND AND CONTROL-SYSTEM IN WAR - THE LATEST ADVANCES IN COMPUTER COMMUNICATIONS TECHNOLOGY WERE PUT TO THEIR 1ST WARTIME TEST DURING OPERATION DESERT STORM SO IEEE COMMUNICATIONS MAGAZINE LA English DT Article RP GIBSON, T (reprint author), US MIL ACAD,COMP SCI,W POINT,NY 10996, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0163-6804 J9 IEEE COMMUN MAG JI IEEE Commun. Mag. PD JAN PY 1992 VL 30 IS 1 BP 52 EP 56 DI 10.1109/35.166650 PG 5 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA GZ849 UT WOS:A1992GZ84900010 ER PT J AU BRENDLER, JA AF BRENDLER, JA TI TACTICAL MILITARY COMMUNICATIONS - THE UNITED-STATES-ARMY BATTLEFIELD INFORMATION ARCHITECTURE WILL MAKE TODAYS SYSTEMS LOOK AS PRIMITIVE AS THE GREASE PENCILS AND CRANK-TO-RING TELEPHONES OF 30 YEARS AGO LOOK TO US SO IEEE COMMUNICATIONS MAGAZINE LA English DT Article RP BRENDLER, JA (reprint author), USAF,CO C,SIGNAL BATTAL AIRBORNE 50,FT BRAGG,NC, USA. NR 6 TC 1 Z9 1 U1 1 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0163-6804 J9 IEEE COMMUN MAG JI IEEE Commun. Mag. PD JAN PY 1992 VL 30 IS 1 BP 62 EP 72 DI 10.1109/35.166652 PG 11 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA GZ849 UT WOS:A1992GZ84900012 ER PT J AU MILLER, LE LEE, JS FRENCH, RH TORRIERI, DJ AF MILLER, LE LEE, JS FRENCH, RH TORRIERI, DJ TI ANALYSIS OF AN ANTIJAM FH ACQUISITION SCHEME SO IEEE TRANSACTIONS ON COMMUNICATIONS LA English DT Article AB An easily implemented matched filter scheme for acquiring hopping code synchronization of incoming frequency-hopping (FH) signals is analyzed, and its performance is evaluated for two types of jamming: partial-band noise jamming and partial-band multitone jamming. The system is designed to reduce jammer-induced false alarms. The system's matched-filter output is compared to an adaptive threshold that is derived from a measurement of the number of acquisition channels being jammed. Example performance calculations are given for the frequency coverage of the jamming either fixed over the entire acquisition period or "hopped," that is, changed for each acquisition pulse in order to prevent the communicator from evading the jamming. The example calculations consider 8 frequencies in the acquisition pattern, chosen from 128 total hop frequencies in the system band. Also, we consider two variations of adaptive threshold. It is shown that the jammer's optimum strategy (the worst case) is to maximize the false-alarm probability without regard for the effect on detection probability, for both partial-band noise and multi-tone jamming. It is also shown by direct comparison with a conventional fixed-threshold scheme that a significantly lower probability of false acquisition results from using an adaptive matched-filter threshold, demonstrating that the matched-filter acquisition strategy studied here is superior to conventional non-adaptive threshold schemes. C1 USA,SURVIVABIL MANAGEMENT OFF,ADELPHI,MD 20783. JS LEE ASSOCIATES INC,SATELLITE COMMUN SYST,ARLINGTON,VA. RP MILLER, LE (reprint author), JS LEE ASSOCIATES INC,ROCKVILLE,MD 20850, USA. NR 5 TC 7 Z9 8 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0090-6778 J9 IEEE T COMMUN JI IEEE Trans. Commun. PD JAN PY 1992 VL 40 IS 1 BP 160 EP 170 DI 10.1109/26.126717 PG 11 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA HL201 UT WOS:A1992HL20100018 ER PT J AU KOH, G AF KOH, G TI EFFECTIVE DIELECTRIC-CONSTANT OF A MEDIUM WITH SPHERICAL INCLUSIONS SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Note ID SCATTERING AB The Maxwell-Garnett theory is frequently used to predict the effective, or the average, dielectric constant of a mixture composed of spherical inclusions embedded in a host medium. This effective medium theory assumes that the volume fraction occupled by the spherical inclusions is small and that the size of the inclusions is small compared to the wavelength. Experiments using controlled samples have shown that the Maxwell-Garnett theory is applicable up to an inclusion volume fraction of 0.2. At higher volume fractions, the effective dielectric constant appears to be dependent on the inclusion sizes. RP KOH, G (reprint author), USA,COLD REG RES & ENGN LAB,CORPS ENGINEERS,GEOPHYS SCI BRANCH,HANOVER,NH 03755, USA. NR 8 TC 6 Z9 6 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD JAN PY 1992 VL 30 IS 1 BP 184 EP 186 DI 10.1109/36.124230 PG 3 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA HC422 UT WOS:A1992HC42200019 ER PT J AU KOSINSKI, JA AF KOSINSKI, JA TI AN OBSERVATION ON QUARTZ RESONATOR AGING SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Letter ID SURFACE-WAVE RESONATORS; INPLANE ACCELERATION SENSITIVITY; RECTANGULAR EDGES RP KOSINSKI, JA (reprint author), USA,LABCOM,ETDL,SLCET,MA,FT MONMOUTH,NJ 07703, USA. NR 55 TC 3 Z9 3 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD JAN PY 1992 VL 39 IS 1 BP 159 EP 161 DI 10.1109/58.166823 PG 3 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA HB397 UT WOS:A1992HB39700020 PM 18263131 ER PT J AU BUCKHEIT, RW WHITE, EL SHANNON, WM GUERRERO, A PIVEL, JP CARRASCO, L LEAL, JA CHIRIGOS, MA AF BUCKHEIT, RW WHITE, EL SHANNON, WM GUERRERO, A PIVEL, JP CARRASCO, L LEAL, JA CHIRIGOS, MA TI SIGNIFICANT ANTI-HIV ACTIVITY OF NEW MODIFIED POLYANIONIC POLYMERS INVITRO SO IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; REVERSE-TRANSCRIPTASE INHIBITORS; ZIDOVUDINE AZT; REPLICATION; AIDS; 3'-AZIDO-3'-DEOXYTHYMIDINE; INFECTIVITY; DERIVATIVES; POTENT AB The anti-HIV activities of two new polyanionic polymers (AM 242 and AM 612) were investigated in cell culture-based and biochemical antiviral assays. These compounds inhibited the reverse transcriptases from HIV-1 and HIV-2, using enzyme purified from virions and either a ribosomal RNA or gapped duplex DNA as the template. With the ribosomal RNA template, AM 242 and AM 612 had ID50 values of 1.1 and 0.10 mug/ml against the HIV-1 reverse transcriptase. In vitro cell based assays determined that both compounds significantly inhibited both the cytopathic effects associated with HIV-1 infection and the replication of virus in infected cells. AM 242 had an IC50 of approximately 1.0 mug/ml, while that of AM 612 was 0.19 mug/ml. These two active polyanionic polymers were effective in inhibiting the growth of a panel of HIV-1 isolates and were also active against HIV-2. Although the compounds were toxic at high concentration, they had antiviral activity over a wide range of nontoxic concentrations, yielding a high selectivity index. AM 612 was 100% protective for CEM cells from 320 ng/ml to 1 mug/ml. Both compounds caused a significant increase in cellular proliferation as determined by the concentration-dependent increase in incorporation of radioactive precursors into cellular macromolecules. C1 ANDROMACO LABS,SA,MADRID,SPAIN. CTR BIOL MOLEC,MADRID,SPAIN. CTR INVEST BIOL,MADRID,SPAIN. USA,INFECT DIS RES INST,FREDERICK,MD 21701. RP BUCKHEIT, RW (reprint author), SO RES INST,BIRMINGHAM,AL 35255, USA. RI Carrasco, Luis/E-2435-2012 FU NIAID NIH HHS [5UO1-AI25617] NR 25 TC 1 Z9 1 U1 0 U2 1 PU MARCEL DEKKER INC PI NEW YORK PA 270 MADISON AVE, NEW YORK, NY 10016 SN 0892-3973 J9 IMMUNOPHARM IMMUNOT JI Immunopharmacol. Immunotoxicol. PY 1992 VL 14 IS 4 BP 707 EP 721 DI 10.3109/08923979209009229 PG 15 WC Immunology; Pharmacology & Pharmacy; Toxicology SC Immunology; Pharmacology & Pharmacy; Toxicology GA KA712 UT WOS:A1992KA71200001 PM 1294618 ER PT J AU LEIBY, DA FORTIER, AH CRAWFORD, RM SCHREIBER, RD NACY, CA AF LEIBY, DA FORTIER, AH CRAWFORD, RM SCHREIBER, RD NACY, CA TI INVIVO MODULATION OF THE MURINE IMMUNE-RESPONSE TO FRANCISELLA-TULARENSIS LVS BY ADMINISTRATION OF ANTICYTOKINE ANTIBODIES SO INFECTION AND IMMUNITY LA English DT Article ID TUMOR-NECROSIS-FACTOR; LISTERIA-MONOCYTOGENES INFECTION; SEVERE COMBINED IMMUNODEFICIENCY; INTERFERON-GAMMA-PRODUCTION; CELL-INDEPENDENT MECHANISM; KILLER NK CELLS; MACROPHAGE ACTIVATION; MONOCLONAL-ANTIBODIES; CHLAMYDIA-TRACHOMATIS; HOST-RESISTANCE AB The role(s) of gamma interferon (IFN-gamma), tumor necrosis factor alpha (TNF-alpha), and interleukin-4 (IL-4) in establishment and maintenance of protective immunity to Francisella tularensis LVS in mice (C3H/HeN) was examined by selective removal of these cytokines in vivo with neutralizing antibodies. The 50% lethal dose (LD50) for mice infected intradermally with F. tularensis alone was 136,000 CFU; treatment of mice with anti-IFN-gamma or anti-TNF-alpha at the time of infection significantly reduced (P < < 0.05) the LD50 to 2 and 5 CFU, respectively. Abrogation of protective immunity, however, was effective only when anti-IFN-gamma or anti-TNF-alpha was administered prior to day 3 postinfection. In contrast, the LD50 for mice treated with anti-IL-4 was repeatedly higher (555,000 CFU) than for controls; this difference, however, was not significant (P > 0.05). Thus, IL-4 may be detrimental, while IFN-gamma and TNF-alpha were clearly crucial to the establishment of protective immunity to F. tularensis during a primary infection. The importance of IFN-gamma and TNF-alpha during a secondary immune response to F. tularensis was also investigated. Spleen cells from immune mice passively transfer protective immunity to recipient mice in the absence of confounding antibody-mediated immunity. This passive transfer of immunity, however, was abrogated by treatment of recipient mice with anti-IFN-gamma or anti-TNF-alpha at the time of challenge infection. That anticytokines effectively abrogate protective immunity very early in the course of infection with F. tularensis suggests that T-cell-dependent activation of macrophages for microbicidal activity is unlikely. These T-cell-independent events early in the course of infection may suppress bacterial replication until a T-cell-dependent response ultimately clears the bacteria. C1 WASHINGTON UNIV,SCH MED,DEPT PATHOL,ST LOUIS,MO 63110. RP LEIBY, DA (reprint author), WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,9620 MED CTR DR,SUITE 200,ROCKVILLE,MD 20850, USA. RI Schreiber, Robert/A-1276-2013 OI Schreiber, Robert/0000-0001-6311-0432 NR 37 TC 149 Z9 150 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD JAN PY 1992 VL 60 IS 1 BP 84 EP 89 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA GW974 UT WOS:A1992GW97400013 PM 1729199 ER PT J AU MILLS, JA VENKATESAN, MM BARON, LS BUYSSE, JM AF MILLS, JA VENKATESAN, MM BARON, LS BUYSSE, JM TI SPONTANEOUS INSERTION OF AN IS1-LIKE ELEMENT INTO THE VIRF GENE IS RESPONSIBLE FOR AVIRULENCE IN OPAQUE COLONIAL VARIANTS OF SHIGELLA-FLEXNERI 2A SO INFECTION AND IMMUNITY LA English DT Article ID CONGO RED BINDING; ENTEROINVASIVE ESCHERICHIA-COLI; INVASION PLASMID; MOLECULAR-CLONING; GEL-ELECTROPHORESIS; NUCLEOTIDE-SEQUENCE; CONTACT HEMOLYSIS; HELA-CELLS; VIRULENCE; DNA AB Colonial variation of Shigella flexneri serotype 2a from the translucent (2457T) to the opaque form (2457O) occurs spontaneously once in 10(4) cell divisions, with concomitant loss of ipa gene expression and virulence. The appearance of 2457O was associated with the insertional inactivation of virF, an invasion plasmid-encoded positive regulator of ipa gene expression. Plasmid pWR110, a Tn5-tagged invasion plasmid that restores the invasive phenotype to plasmid-cured Shigella derivatives, was conjugally transferred into 2457O. Synthesis of the invasion-associated IpaB and IpaC polypeptides, normally present on the surface of virulent shigellae, and the invasive phenotype were restored in 2457O(pWR110) transconjugants. Plasmid DNA restriction endonuclease patterns of 2457T and 2457O, along with hybridization analysis, showed that a SalI fragment carrying the virF gene in 2457O had increased in size relative to its counterpart in 2457T. Analysis of virF DNA sequences amplified by the polymerase chain reaction revealed that the virF sequence from 2457O was 780 bp larger than that amplified from 2457T. Moreover, the virF sequence amplified from 2457O hybridized to an IS1 DNA probe whereas the amplified 2457T virF sequence did not. DNA sequence analysis mapped the insertion element, designated IS1SFO, within an A. T-rich region of the virF open reading frame and identified a 9-bp virF target sequence that was duplicated at the insertion site of IS1SFO. The DNA sequence of IS1SFO was > 99% homologous to IS1F. Plasmid pWR600, carrying a 1,260-bp HpaII fragment encoding a wild-type virF gene, was able to restore the virulent phenotype and translucent colonial morphology to nine independently isolated 2457O hosts. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BACTERIAL IMMUNOL,WASHINGTON,DC 20307. NR 59 TC 24 Z9 25 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD JAN PY 1992 VL 60 IS 1 BP 175 EP 182 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA GW974 UT WOS:A1992GW97400026 PM 1309511 ER PT J AU MCQUEEN, CE BOEDEKER, EC LE, M HAMADA, Y BROWN, WR AF MCQUEEN, CE BOEDEKER, EC LE, M HAMADA, Y BROWN, WR TI MUCOSAL IMMUNE-RESPONSE TO RDEC-1 INFECTION - STUDY OF LAMINA PROPRIA ANTIBODY-PRODUCING CELLS AND BILIARY ANTIBODY SO INFECTION AND IMMUNITY LA English DT Article ID ESCHERICHIA-COLI RDEC-1; PEYERS PATCH; AF/R1 PILI; INTESTINAL-MUCOSA; STRAIN RDEC-1; RABBIT; DIARRHEA; ADHERENCE; ANTIGEN; IGA AB Infection of rabbits with Escherichia coli RDEC-1 is a useful model for diarrheal disease caused by mucosally attaching E. coli. Understanding of the protective immunity induced by RDEC-1 infection in rabbits should provide information useful in the design of vaccines for protection against this infection and other mucosally attaching organisms as well. Thus, to define the time course and location of specific immunoglobulin A secretion in relation to bacterial colonization during primary RDEC-1 infection, we infected rabbits with RDEC-1, which express AF/R1 adherence pili, and compared sites of anti-AF/R1 antibody-containing cells in the intestinal mucosa with the sites of luminal colonization and mucosal attachment of RDEC-1. Also, anti-AF/R1 antibodies in intestinal fluids and bile were measured by enzyme-linked immunosorbent assay, and attachment sites of RDEC-1 to the intestinal epithelium were determined by immunohistochemical examination. Anti-AF/R1 pilus antibody-containing cells were most numerous in the proximal intestine (duodenum and jejunum). In contrast, both luminal colonization and attachment of RDEC-1 to epithelial cells were densest in the distal intestine (cecum and colon). Anti-AF/R1 antibodies were present in approximately equal amounts in fluids collected from all levels of the gut after week 1 postinfection. Anti-AF/R1 antibody levels in undiluted bile exceeded those in gut flushes by at least 2 orders of magnitude. Loss of RDEC-1 attachment to epithelial cells preceded resolution of diarrheal illness despite the presence of large numbers of organisms in the intestinal lumen. Our studies indicate that during RDEC-1 infection (i) sites of greatest mucosal anti-AF/R1 antibody secretion are proximal to sites of maximal RDEC-1 luminal colonization and attachment, (ii) bile is a major source of specific antibodies in the intestinal lumen, and (iii) interference with RDEC-1 attachment to epithelial cells may permit resolution of disease. C1 VET ADM MED CTR,DEPT MED,DENVER,CO 80220. UNIV COLORADO,SCH MED,DENVER,CO 80202. RP MCQUEEN, CE (reprint author), WALTER REED ARMY MED CTR,DEPT GASTROENTEROL,WASHINGTON,DC 20307, USA. NR 32 TC 17 Z9 17 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD JAN PY 1992 VL 60 IS 1 BP 206 EP 212 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA GW974 UT WOS:A1992GW97400031 PM 1345908 ER PT J AU GUTHRIE, S MANIVANNAN, S AF GUTHRIE, S MANIVANNAN, S TI A KNOWLEDGE-BASED ASSIGNMENT METHODOLOGY FOR PERSONAL IDENTIFICATION IN MASS DISASTER SO INFORMATION AND DECISION TECHNOLOGIES LA English DT Article AB A knowledge-based assignment methodology (KBAM) for providing decision support to forensic scientists in the skeletal identification process is discussed. A mathematical framework for KBAM is developed that integrates a knowledge base with a network flow algorithm to resolve conflicts during the identification process. The KBAM framework has been implemented on an IBM-PC and includes an observation advisor, an assignment advisor and a conflict resolution module. Knowledge acquisition and representation issues are discussed along with a numerical example and results. C1 GEORGIA INST TECHNOL,SCH IND & SYST ENGN,ATLANTA,GA 30332. USA,OFF DEPUTY CHIEF STAFF PERSONNEL,WASHINGTON,DC 20310. NR 11 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0923-0408 J9 INFORM DECIS TECHNOL PY 1992 VL 18 IS 5 BP 309 EP 322 PG 14 WC Operations Research & Management Science SC Operations Research & Management Science GA KB089 UT WOS:A1992KB08900002 ER PT J AU LOWRY, MA MELLEN, PF AF LOWRY, MA MELLEN, PF TI LOW-VOLTAGE ELECTROTHERMAL NECK INJURY SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED LA English DT Article RP LOWRY, MA (reprint author), WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0020-1383 J9 INJURY JI Injury-Int. J. Care Inj. PY 1992 VL 23 IS 3 BP 205 EP 206 DI 10.1016/S0020-1383(05)80052-X PG 2 WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery GA HL250 UT WOS:A1992HL25000021 PM 1587580 ER PT J AU LOWRANCE, JL JOSEPH, CL LEUPOLD, H POTENZIANI, E AF LOWRANCE, JL JOSEPH, CL LEUPOLD, H POTENZIANI, E TI PERMANENT-MAGNET FOCUSED XUV IMAGE SENSOR SO INSTITUTE OF PHYSICS CONFERENCE SERIES LA English DT Article AB This paper presents the design and analysis of a windowless image intensifier with a 1 x 15 cm photocathode and electron bombarded CCD anode. The magnetic focus field is provided by a light weight permanent magnet assembly of novel design. Calculations of the magnetic field and resulting spatial frequency response are also included, showing that this type of image sensor would be well suited to Rowland circle type XUV spectrographs. C1 USA, ELECTR TECHNOL & DEVICES LAB, FT MONMOUTH, NJ 07703 USA. RP LOWRANCE, JL (reprint author), PRINCETON SCI INSTRUMENTS, 7 DEER PK DR, MONMOUTH JCT, NJ 08852 USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0951-3248 J9 INST PHYS CONF SER JI Inst. Phys. Conf. Ser. PY 1992 IS 121 BP 75 EP 84 PG 10 WC Physics, Multidisciplinary SC Physics GA HV057 UT WOS:A1992HV05700010 ER PT J AU JOHNSON, CB PATTON, SB BENDER, E AF JOHNSON, CB PATTON, SB BENDER, E TI HIGH-RESOLUTION MICROCHANNEL PLATE IMAGE TUBE RESULTS SO INSTITUTE OF PHYSICS CONFERENCE SERIES LA English DT Article AB The present 18 mm active diameter proximity focused microchannel plate (MCP) image tube design has been modified to produce significantly higher limiting spatial resolution. A glass input window of the "bulls-eye" design with the blackened glass border, reduced cathode-to-MCP spacing, reduced channel center-to-center distance, reduced MCP-to-phosphor screen spacing, a brushed P20 phosphor screen, and a fiber optic output window were used to achieve a limiting resolution in excess of 50 lp/mm. Test results, showing limiting resolution vs applied potentials, are correlated with a simple physical model of performance. The low-light-level white-light sinewave modulation transfer function, T(f), has been measured to be T(f) = exp(-(f/21.5)1.46), where f is the spatial frequency in cycles per millimeter. C1 ITT, DIV ELECTROOPT PROD, FT WAYNE, IN 46801 USA. USA, BELVOIR RES DEV & EDUC CTR, CTR NIGHT VIS & ELECTROOPT, AMSEL RD NV, FT BELVOIR, VA 22060 USA. RP JOHNSON, CB (reprint author), LITTON ELECTRON DEVICES, 1215 S 52ND ST, TEMPE, AZ 85281 USA. NR 4 TC 0 Z9 0 U1 2 U2 2 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0951-3248 J9 INST PHYS CONF SER JI Inst. Phys. Conf. Ser. PY 1992 IS 121 BP 193 EP 200 PG 8 WC Physics, Multidisciplinary SC Physics GA HV057 UT WOS:A1992HV05700024 ER PT J AU PEREZ, RS GREGORY, MR MINIONIS, DP AF PEREZ, RS GREGORY, MR MINIONIS, DP TI TOOLS AND DECISION AIDS FOR TRAINING DEVELOPMENT IN THE UNITED-STATES-ARMY SO INSTRUCTIONAL SCIENCE LA English DT Article AB In this article we present a review of some of the automation efforts currently being conducted by the U.S. Army. First, we provide a description of current training development procedures used in the Army, the problems of training development in the Army, and a discussion of how we propose to solve these training development problems. We then describe our research approach and methodology, the prototype tools and decision aids developed under this effort, how our efforts on the design and development of the Automated Systems Approach to Training system (ASAT) have led to a functional description for an operational AS AT system, and finally, a discussion of the research issues addressed as part of this effort. C1 USA,CTR TRAINING SUPPORT,FT EUSTIS,VA 23604. RP PEREZ, RS (reprint author), USA,RES INST,ALEXANDRIA,VA 22333, USA. NR 12 TC 0 Z9 0 U1 3 U2 3 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0020-4277 J9 INSTR SCI JI Instr. Sci. PY 1992 VL 21 IS 4 BP 225 EP 237 PG 13 WC Education & Educational Research; Psychology, Educational SC Education & Educational Research; Psychology GA LA620 UT WOS:A1992LA62000002 ER PT J AU ROSEN, JB SUN, SZ XUE, GL AF ROSEN, JB SUN, SZ XUE, GL TI ON A NEW ALGORITHM FOR STABLE ASSIGNMENT SO INTERNATIONAL JOURNAL OF COMPUTER MATHEMATICS LA English DT Article DE STABLE ASSIGNMENT PROBLEM; COUNTEREXAMPLE C1 USA,HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55415. RP ROSEN, JB (reprint author), UNIV MINNESOTA,DEPT COMP SCI,MINNEAPOLIS,MN 55455, USA. NR 2 TC 1 Z9 1 U1 0 U2 0 PU GORDON BREACH SCI PUBL LTD PI READING PA C/O STBS LTD PO BOX 90, READING, BERKS, ENGLAND RG1 8JL SN 0020-7160 J9 INT J COMPUT MATH JI Int. J. Comput. Math. PY 1992 VL 41 IS 3-4 BP 165 EP 167 DI 10.1080/00207169208804036 PG 3 WC Mathematics, Applied SC Mathematics GA HM338 UT WOS:A1992HM33800004 ER PT J AU MAJOR, MA CHECKAI, RT PHILLIPS, CT WENTSEL, RS NWANGUMA, RO AF MAJOR, MA CHECKAI, RT PHILLIPS, CT WENTSEL, RS NWANGUMA, RO TI METHOD FOR SCREENING AND ANALYSIS OF RESIDUES COMMON TO MUNITION OPEN BURNING OPEN DETONATION (OB OD) SITES SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY LA English DT Article DE MUNITION RESIDUES; EXPLOSIVES; TNT; HMX; RDX; OPEN BURNING OPEN DETONATION; OB OD AB Procedures are presented for qualitative screening and subsequent quantitation of residues of explosives and related compounds found at sites contaminated by open burning/open detonation (OB/OD) disposal of munitions. Methods are reported for recovery of explosives and polycyclic aromatic hydrocarbons (PAHs) from soil via sonic extraction into acetonitrile; and explosives from water via trapping onto C18 disposable cartridges. Complimentary HPLC procedures were used for identification and quantification of these compounds. A qualitative HPLC gradient method was developed, and used to screen samples for a wide range of explosives and PAHs. Quantitation of explosives and their environmental reduction products was accomplished using HPLC isocratic methods. Recoveries of explosives and degradation products doped into sandy loam soil were greater than 90%. Corresponding recoveries from aqueous samples were comparable for the nitroaromatics, but were poorer for the nitramines. Criteria of detection for individual munition residues ranged from 0.067 mg l-1 to 0.37 mg l-1. C1 USA,CTR CHEM RES DEV & ENGN,DIV TOXICOL,ENVIRONM TOXICOL BRANCH,ABERDEEN PROVING GROUND,MD 21010. GEOCENTERS INC,FT WASHINGTON,MD 20744. RP MAJOR, MA (reprint author), USA,BIOMED RES & DEV LAB,FT DETRICK,FREDERICK,MD 21701, USA. NR 19 TC 9 Z9 9 U1 0 U2 1 PU GORDON BREACH SCI PUBL LTD PI READING PA C/O STBS LTD PO BOX 90, READING, BERKS, ENGLAND RG1 8JL SN 0306-7319 J9 INT J ENVIRON AN CH JI Int. J. Environ. Anal. Chem. PY 1992 VL 48 IS 3-4 BP 217 EP 227 DI 10.1080/03067319208027402 PG 11 WC Chemistry, Analytical; Environmental Sciences SC Chemistry; Environmental Sciences & Ecology GA JR949 UT WOS:A1992JR94900008 ER PT J AU HANCHAK, SJ FORRESTAL, MJ YOUNG, ER EHRGOTT, JQ AF HANCHAK, SJ FORRESTAL, MJ YOUNG, ER EHRGOTT, JQ TI PERFORATION OF CONCRETE SLABS WITH 48-MPA (7-KSI) AND 140-MPA (20-KSI) UNCONFINED COMPRESSIVE STRENGTHS SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article AB We conducted perforation experiments with 25.4-mm diameter, 0.50-kg, 3.0-caliberradius-head, ogival-nose rods and 178-mm-thick concrete slabs with 48 MPa (7 ksi) and 140 MPa (20 ksi) unconfined compressive strengths. For impact velocities between 300 and 1100 m/s, our data showed that residual velocities for the 140 MPa concrete were less than 20% lower than that for the 48 MPa concrete. Thus, for a factor of three increase in unconfined compressive strength, we measured relatively minor changes in ballistic perforation performance. We explained these results qualitatively with post-test observations and triaxial material experiments with the 48 and 140 MPa concrete materials. C1 SANDIA NATL LABS,ALBUQUERQUE,NM 87185. WATERWAYS EXPT STN,VICKSBURG,MS. RP HANCHAK, SJ (reprint author), UNIV DAYTON,RES INST,DAYTON,OH 45469, USA. NR 6 TC 121 Z9 161 U1 2 U2 12 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PY 1992 VL 12 IS 1 BP 1 EP 7 DI 10.1016/0734-743X(92)90282-X PG 7 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA HM380 UT WOS:A1992HM38000001 ER PT J AU BJERKE, TW ZUKAS, JA KIMSEY, KD AF BJERKE, TW ZUKAS, JA KIMSEY, KD TI PENETRATION PERFORMANCE OF DISK SHAPED PENETRATORS SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article ID STEEL TARGETS; RODS; IMPACT AB A combined computational, analytical and experimental investigation has discovered that there is a limit to the penetration efficiency of kinetic energy penetrators as the length-to-diameter ratio (L/D) is decreased. Impacts of penetrators with an L/D ranging from 1 to 1/32 into rolled homogeneous armor (RHA) at 2 km s were modelled with the Lagrangian code SMASH, the Eulerian code CTH, and elementary wave mechanics. Results were verified with experiments performed using a 50 mm high pressure powder gun and a push-launch sabot. The modelling exhibited good agreement with experimental data and provided significant insight into the transient behavior of low L/D penetrator impacts. RP BJERKE, TW (reprint author), USA,BALLIST RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 38 TC 17 Z9 18 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PY 1992 VL 12 IS 2 BP 263 EP 280 DI 10.1016/0734-743X(92)90460-B PG 18 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA JG296 UT WOS:A1992JG29600007 ER PT J AU BJERKE, TW SILSBY, GF SCHEFFLER, DR MUDD, RM AF BJERKE, TW SILSBY, GF SCHEFFLER, DR MUDD, RM TI YAWED LONG-ROD ARMOR PENETRATION SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article AB The terminal ballistic behavior of ductile tungsten alloy long-rod penetrators is examined as impact yaw is increased from values of approximately zero to those which cause penetration performance to significantly decrease. The impact signatures remaining in the target crater from high yaw impacts are examined and used to identify thc physical mechanisms which cause penetrator performance to degrade. A threshold limit of penetrator yaw beyond which penetration performance decreases is derived. An empirically based model which quantifies the decrease in penetration due to yaw once this threshold limit is exceeded is presented for impacts with normal incidence semi-infinite RHA targets. The results from a computational effort using the HULL code to simulate high yaw impacts are presented and compared with the empirical penetration degradation model. RP BJERKE, TW (reprint author), USA,BALLIST RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 18 TC 32 Z9 36 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PY 1992 VL 12 IS 2 BP 281 EP 292 DI 10.1016/0734-743X(92)90473-7 PG 12 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA JG296 UT WOS:A1992JG29600008 ER PT J AU COCHRAN, J PRASAD, V AF COCHRAN, J PRASAD, V TI HEMISPHERIC PRIMING - EFFECT OF RESPONSE-MODE ON A POSITION REPLICATION TASK SO INTERNATIONAL JOURNAL OF NEUROSCIENCE LA English DT Article DE PRIMING; INTERFERENCE; POSITIONING; KINESTHESIS; LATERALITY; SEX ID LATERAL EYE-MOVEMENTS; CEREBRAL LATERALIZATION; UNIMANUAL SKILL; HUMAN-BRAIN; LOCATION AB Ten male and ten female dextral subjects performed a kinesthetic position replication task under two response mode conditions; in one block, subjects indicated their decision by a lateralized verbal response and in the other block, by a midline chin-lift response. Response mode was found to interact with arm, excursion length, end position, and sex. This interaction is interpreted to reflect the influence of verbal preparation on the relative balance between a left hemisphere-biased strategy of kinesthetic positioning and a right hemisphere-biased strategy involving a spatial reference system. C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 37 TC 0 Z9 0 U1 3 U2 3 PU GORDON BREACH SCI PUBL LTD PI READING PA C/O STBS LTD PO BOX 90, READING, BERKS, ENGLAND RG1 8JL SN 0020-7454 J9 INT J NEUROSCI JI Int. J. Neurosci. PY 1992 VL 66 IS 3-4 BP 197 EP 207 PG 11 WC Neurosciences SC Neurosciences & Neurology GA JW359 UT WOS:A1992JW35900006 PM 1305619 ER PT J AU WRIGHT, TW AF WRIGHT, TW TI SHEAR BAND SUSCEPTIBILITY - WORK-HARDENING MATERIALS SO INTERNATIONAL JOURNAL OF PLASTICITY LA English DT Article AB A phenomenological model of a rigid, work hardening, plastic material, with rate hardening and thermal softening, is analysed to determine susceptibility to the formation of adiabatic shear bands. The approach used is to examine perturbation equations that are linearized about a homogeneous solution of the full nonlinear problem. It is found that, in general, solutions to these linearized equations exhibit a strong initial boundary layer in time, and that the traditional approach, that is, analysis of frozen eigenvalues, cannot be relied upon to determine stability against initial perturbations. A variety of special techniques are used to approximate solutions for the fully time-dependent behavior. These techniques include asymptotic expansions of exact representations, WKB analysis of the equations that govern the Fourier components, and numerical analysis by spectral methods of both the linearized and nonlinear equations. Although solutions to the linearized equations are valid only for finite time when perturbations are growing, it is still possible to obtain a basic scaling law for comparing susceptibility of different materials. RP WRIGHT, TW (reprint author), USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005, USA. NR 8 TC 33 Z9 34 U1 1 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0749-6419 J9 INT J PLASTICITY JI Int. J. Plast. PY 1992 VL 8 IS 5 BP 583 EP 602 DI 10.1016/0749-6419(92)90032-8 PG 20 WC Engineering, Mechanical; Materials Science, Multidisciplinary; Mechanics SC Engineering; Materials Science; Mechanics GA JH664 UT WOS:A1992JH66400005 ER PT J AU WALTER, JW AF WALTER, JW TI NUMERICAL EXPERIMENTS ON ADIABATIC SHEAR BAND FORMATION IN ONE DIMENSION SO INTERNATIONAL JOURNAL OF PLASTICITY LA English DT Article AB Adiabatic shear band formation in an elastic, thermoviscoplastic, simple material is studied in the context of unidirectional shearing of a slab. The effect of varying the thermal softening behavior of the material on localization strain and postlocalization morphology is studied for a rigid, perfectly plastic material; the material parameters are appropriate for a high-strength steel. In this case it is demonstrated that localization of the strain rate can be transient. A coupling between linear-elastic response and the basic thermoviscoplastic localization mechanism is explored in the absence of strain hardening. Last, the flow law is modified to include strain hardening in order to simulate a high-rate torsion test on OFHC copper. In this case localization is initiated by thermal boundary layer diffusion and the solution takes on a complex, apparently nonperiodic, postlocalization morphology quite different from that in the perfectly plastic cases. RP WALTER, JW (reprint author), USA, BALLIST RES LABS, ABERDEEN PROVING GROUND, MD 21005 USA. NR 34 TC 40 Z9 41 U1 1 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0749-6419 J9 INT J PLASTICITY JI Int. J. Plast. PY 1992 VL 8 IS 6 BP 657 EP 693 DI 10.1016/0749-6419(92)90023-6 PG 37 WC Engineering, Mechanical; Materials Science, Multidisciplinary; Mechanics SC Engineering; Materials Science; Mechanics GA JT907 UT WOS:A1992JT90700003 ER PT J AU KING, JW KASSEL, RJ AF KING, JW KASSEL, RJ TI MOLECULAR TRANSFORM QUANTIZATION OF ENZYME SURFACE PROBES SO INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY LA English DT Article; Proceedings Paper CT 32ND SANIBEL INTERNATIONAL SYMP ON THE APPLICATION OF FUNDAMENTAL THEORY TO PROBLEMS OF BIOLOGY AND PHARMACOLOGY CY MAR 14-21, 1992 CL ST AUGUSTINE, FL SP USA, RES OFF PHYS, USN, OFF NAVAL RES, US DOE, OFF HLTH & ENV RES, HYPER CHEM, AUTODESK, TEKTRONIX, UNIV FLORIDA, OFF ACAD AFFAIRS AB Inhibition of enzyme function by series of appropriate substrates is the first step in the classical approach to definition of the reactive or binding sites on an enzyme surface. Several years ago, M. 1. Kabachnik and his colleagues published inhibition rate data for acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) by phosphonates and phosphates. Some of the phosphonate data has been reexamined from a structure-activity point of view using the square root of the integrated molecular transform as a unitary structure descriptor. Linear regressions showed good correlations in the BuChE case; less adequate correlations were manifested with the AChE data. This is attributable to the predominantly lipophilic nature of the interaction between BuChE and substrates as compared to AChE, where electronic factors may have a prominent role. The correlations further suggest a different, but nontrivial, mode of action between the respective enzymes and their substrates. RP KING, JW (reprint author), USA,CHEM RES,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010, USA. NR 9 TC 1 Z9 1 U1 0 U2 0 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0020-7608 J9 INT J QUANTUM CHEM JI Int. J. Quantum Chem. PY 1992 SU 19 BP 179 EP 185 PG 7 WC Chemistry, Physical; Mathematics, Interdisciplinary Applications; Physics, Atomic, Molecular & Chemical SC Chemistry; Mathematics; Physics GA JY535 UT WOS:A1992JY53500014 ER PT B AU PETERS, CJ JAHRLING, PB KSIAZEK, TG JOHNSON, ED LUPTON, HW AF PETERS, CJ JAHRLING, PB KSIAZEK, TG JOHNSON, ED LUPTON, HW GP INT ASSOC BIOL STANDARDIZAT TI FILOVIRUS CONTAMINATION OF CELL-CULTURES SO INTERNATIONAL SYMPOSIUM ON CONTINUOUS CELL LINES - AN INTERNATIONAL WORKSHOP ON CURRENT ISSUES SE DEVELOPMENTS IN BIOLOGICAL STANDARDIZATION LA English DT Proceedings Paper CT INTERNATIONAL SYMP ON CONTINUOUS CELL LINES CY MAR 20-22, 1991 CL NIH CAMPUS, BETHESDA, MD SP US FDA, CTR BIOL EVALUAT & RES, NIAID, NATL VACCINE PROGRAM OFF, WHO HO NIH CAMPUS RP PETERS, CJ (reprint author), USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FT DETRICK,FREDERICK,MD 21701, USA. NR 0 TC 15 Z9 15 U1 0 U2 1 PU KARGER PI BASEL PA BASEL BN 3-8055-5618-7 J9 DEV BIOLOGICALS JI Dev. Biols PY 1992 VL 76 BP 267 EP 274 PG 8 WC Biology; Immunology SC Life Sciences & Biomedicine - Other Topics; Immunology GA BW99W UT WOS:A1992BW99W00031 PM 1478345 ER PT B AU BOTTIN, RR AF BOTTIN, RR GP YANGTZE RIVER SCI RES INST TI HYDRAULIC MODELING AND SUBSEQUENT PROTOTYPE PERFORMANCE OF SMALL-BOAT HARBORS SO INTERNATIONAL SYMPOSIUM ON HYDRAULIC RESEARCH IN NATURE AND LABORATORY, VOLS 1-3 LA English DT Proceedings Paper CT International Symposium on Hydraulic Research in Nature and Laboratory CY NOV 17-20, 1992 CL WUHAN, PEOPLES R CHINA SP YANGTZE RIVER SCI RES INST, CHINESE SOC HYDROELECT ENGN, HYDRAUL COMM, CHINESE HYDRAUL ENGN SOC, YANGTZE VALLEY PLANNING OFF, INT ASSOC HYDRAUL RES, INT ASSOC HYDRAUL RES, ASIAN PACIFIC REG DIV C1 USA,COASTAL ENGN RES CTR,WATERWAYS EXPT STN,VICKSBURG,MS 39180. NR 0 TC 0 Z9 0 U1 0 U2 0 PU YANGTZE RIVER SCIENTIFIC RESEARCH INST INFORMATION DIV PI WUHAN PA 23 HUANG PU ROAD, WUHAN 430010, PEOPLES R CHINA PY 1992 BP B376 EP B381 PG 6 WC Engineering, Civil SC Engineering GA BA40P UT WOS:A1992BA40P00134 ER PT J AU MCKEE, KT ORO, JGB KUEHNE, AI SPISSO, JA MAHLANDT, BG AF MCKEE, KT ORO, JGB KUEHNE, AI SPISSO, JA MAHLANDT, BG TI CANDID NO-1 ARGENTINE HEMORRHAGIC-FEVER VACCINE PROTECTS AGAINST LETHAL JUNIN VIRUS CHALLENGE IN RHESUS MACAQUES SO INTERVIROLOGY LA English DT Article DE JUNIN VIRUS; CANDID NO-1; ARGENTINE HEMORRHAGIC FEVER; VIRAL HEMORRHAGIC FEVER; VACCINE; ANIMAL MODEL; ARENAVIRUS AB The protective efficacy of Candid No. 1, a live-attenuated vaccine against Argentine hemorrhagic fever (AHF), was evaluated in non-human primates. Twenty rhesus macaques immunized 3 months previously with graded doses of Candid No. 1 (16-127, 000 PFU), as well as 4 placebo-inoculated controls, were challenged with 4.41 log10 PFU of virulent P3790 strain Junin virus. All controls developed severe clinical disease; 3 of 4 died. In contrast, all vaccinated animals were fully protected; none developed any signs of AHF during a 105-day follow-up period. Viremia and virus shedding were readily detected in all placebo-vaccinated controls, while virus could be recovered only once (by amplification) from throat swabs of 2 Candid No. 1 vaccinees on day 21. Vigorous secondary-type neutralizing and immunofluorescent antibody responses were seen in most vaccinees that had received 3 log10 PFU Candid No. 1 or fewer; all others, including those receiving 127,200 PFU, maintained relatively stable titers during follow-up. Candid No. 1 was highly immunogenic and fully protective against lethal Junin virus challenge in rhesus macaques, even at extremely low (16 PFU) vaccine doses. C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. NR 16 TC 32 Z9 32 U1 0 U2 0 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0300-5526 J9 INTERVIROLOGY JI Intervirology PY 1992 VL 34 IS 3 BP 154 EP 163 PG 10 WC Virology SC Virology GA KY637 UT WOS:A1992KY63700006 PM 1338783 ER PT J AU KENYON, RH MCKEE, KT ZACK, PM RIPPY, MK VOGEL, AP YORK, C MEEGAN, J CRABBS, C PETERS, CJ AF KENYON, RH MCKEE, KT ZACK, PM RIPPY, MK VOGEL, AP YORK, C MEEGAN, J CRABBS, C PETERS, CJ TI AEROSOL INFECTION OF RHESUS MACAQUES WITH JUNIN VIRUS SO INTERVIROLOGY LA English DT Article DE JUNIN VIRUS; AEROSOL; INTERFERON; ENZYME-LINKED IMMUNOSORBENT ASSAY ID ARGENTINE HEMORRHAGIC-FEVER; INTERFERON AB The purpose of our work was to determine if aerosols of Junin virus can infect rhesus macaques and if the disease is the same as that produced by virus inoculated parenterally. The 6 macaques exposed to the virus by aerosol became acutely ill during the 3rd week after exposure, and all died. Three died by day 21, while the remainder died after 1 month. Junin virus was found primarily in visceral organs of those animals dying before 21 days after infection and in the central nervous system tissues from animals dying later. Histological changes were similar to those reported in rhesus monkeys after parenteral Junin viral infection. Gastrointestinal necrosis, however, was less severe in aerosol-infected animals and the associated septicemia was not seen. High levels of alpha interferon were detected by the 3rd day in all infected macaques. Experimental Argentine hemorrhagic fever induced by aerosol infection in rhesus macaques was similar to that seen after parenteral challenge and mimicked closely the clinical syndrome observed in humans. C1 USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FREDERICK,MD 21701. USA,MED RES INST INFECT DIS,DIV MED,FREDERICK,MD 21701. USA,MED RES INST INFECT DIS,DIV PATHOL,FREDERICK,MD 21701. NR 18 TC 30 Z9 31 U1 0 U2 0 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0300-5526 J9 INTERVIROLOGY JI Intervirology PD JAN-FEB PY 1992 VL 33 IS 1 BP 23 EP 31 PG 9 WC Virology SC Virology GA GW919 UT WOS:A1992GW91900004 PM 1371270 ER PT B AU SLINEY, DH PATTERSON, RM AF SLINEY, DH PATTERSON, RM GP INT RADIAT PROTECT ASSOC TI GUIDELINES FOR EXPOSURE TO SUB-RADIOFREQUENCY ELECTRIC AND MAGNETIC FIELDS SO IRPA8 - EIGHTH INTERNATIONAL CONGRESS OF THE INTERNATIONAL RADIATION PROTECTION ASSOCIATION - WORLDWIDE ACHIEVEMENT IN PUBLIC AND OCCUPATIONAL HEALTH PROTECTION AGAINST RADIATION, VOL I LA English DT Proceedings Paper CT 8th International Congress of the International-Radiation-Protection-Association - Worldwide Achievement in Public and Occupational Health Protection Against Radiation CY MAY 17-22, 1992 CL MONTREAL, CANADA SP INT RADIAT PROTECT ASSOC, CANADIAN RADIAT PROTECT ASSOC C1 USA,ARMY ENVIRONM HYG AGCY,DIV LASER MICROWAVE,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INT RADIATION PROTECTION ASSOC PI MONTREAL PA 2155 RUE GUY, BUREAU 820, MONTREAL PQ H3H 2R9, CANADA BN 1-55048-657-8 PY 1992 BP 925 EP 928 PG 4 WC Public, Environmental & Occupational Health; Instruments & Instrumentation; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Public, Environmental & Occupational Health; Instruments & Instrumentation; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA BC18J UT WOS:A1992BC18J00233 ER PT J AU GRANT, CL MCGEE, IE JENKINS, TF STUTZ, MH AF GRANT, CL MCGEE, IE JENKINS, TF STUTZ, MH TI SPECIFICATION-BASED MODIFIED CONTROL LIMITS IN QUALITY-CONTROL OF TRACE CHEMICAL-ANALYSES SO JOURNAL OF AOAC INTERNATIONAL LA English DT Article; Proceedings Paper CT 105TH ANNUAL INTERNATIONAL MEETING OF THE ASSOC OF OFFICIAL ANALYTICAL CHEMISTS CY AUG 12-15, 1991 CL PHOENIX, AZ SP ASSOC OFF ANALYT CHEMISTS AB Shewhart XBAR and R charts were used to maintain and validate data quality of percent recovery estimates for 8 analytes determined by 4 procedures used routinely in 4 commercial laboratories over a 2-year period. However, because range (R) estimates of uncertainty did not include lot-to-lot calibration variability, approximately 24% of the lots were "out-of-control." We extracted pooled standard deviations for S(O) (repeatability within lot), S(L) (calibration variability), and S(R) (reproducibility), which represents the total variability. Values of S(O) and S(L) were generally similar in size although there were some substantial differences between analytes and between laboratories for a given analyte. When control limits were based on reproducibility rather than repeatability, only about 6% of the lots were "out-of-control." However, these limits are less convenient to compute at the bench, within-lot precision estimates are still required, and there is still no information on data acceptability. Capability estimates from the grand mean +/- 3 S(R) were surprisingly consistent for the 8 analytes. These values coupled with data quality objectives suggested the 82-115% range as the specifications for acceptable individual recoveries. A combination of repeatability limits plus modified limits anchored to specifications retains the simplicity of range computations while offering substantial administrative advantages. Examples are given to illustrate these points. C1 USA,CORPS ENGINEERS,COLD REG RES & ENGN LAB,HANOVER,NH 03755. USA,CORPS ENGINEERS,TOX & HAZARDOUS MAT AGCY,ABERDEEN PROVING GROUND,MD 21010. RP GRANT, CL (reprint author), UNIV NEW HAMPSHIRE,DEPT CHEM,DURHAM,NH 03824, USA. NR 11 TC 0 Z9 0 U1 0 U2 0 PU AOAC INTERNATIONAL PI GAITHERSBURG PA 481 NORTH FREDRICK AVE, STE 500, GAITHERSBURG, MD 20877-2504 SN 1060-3271 J9 J AOAC INT JI J. AOAC Int. PD JAN-FEB PY 1992 VL 75 IS 1 BP 39 EP 45 PG 7 WC Chemistry, Analytical; Food Science & Technology SC Chemistry; Food Science & Technology GA HK107 UT WOS:A1992HK10700010 ER PT J AU NETHERLAND, MD GETSINGER, KD AF NETHERLAND, MD GETSINGER, KD TI EFFICACY OF TRICLOPYR ON EURASIAN WATERMILFOIL - CONCENTRATION AND EXPOSURE TIME EFFECTS SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE HERBICIDE; CHEMICAL CONTROL; GARLON 3A; EXPOSURE TIME; MYRIOPHYLLUM-SPICATUM AB Herbicide concentration and exposure time relationships were determined for the triethylamine salt formulation of triclopyr (3,5,6-trichloro-2-pyridinyloxyacetic acid) and control of Eurasian watermilfoil (Myriophyllum spicatum L.) under controlled-environment conditions. Thirty-four combinations of triclopyr concentration and exposure time were tested: concentrations ranged from 0.25 to 2.5 mg acid equivalent (ae)/1; exposure times ranged from 2 to 84 hr. Plant control was based on shoot and root biomass harvested at 5 weeks posttreatment. Weekly visual injury ratings were used to characterize initial injury response and recuperative ability of plants following treatment. Plant response was rapid and most treatments resulted in severe injury to existing tissue with the majority of regrowth coming from rootcrowns and lower stems. Plant control increased (biomass decreased) as concentration and/or exposure times were increased until a threshold level was reached which provided complete plant control. Excellent control (> 85% biomass reduction) was achieved at concentration/exposure time combinations of 0.25 mg ae/l for 72 hr, 0.5 mg/l for 48 hr, 1.0 mg/l for 36 hr, 1.5 mg/l for 24 hr, and 2.0 and 2.5 mg/l for 18 hr. Treatments of 2.5 mg/l for 2 hr, 1.0 mg/l for 6 hr, and 0.25 and 0.5 mg/l for 12 hr were ineffective and produced only minor initial injury symptoms followed by rapid plant growth. Results indicate that increased Eurasian watermilfoil control is likely in systems where plants remain in contact with triclopyr concentrations greater than developed threshold levels. RP NETHERLAND, MD (reprint author), USA,ENGINEER WATERWAYS EXPT STN,ENVIRONM LAB,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 17 TC 40 Z9 41 U1 1 U2 3 PU AQUATIC PLANT MANAGEMENT SOC, INC PI CLERMONT PA PO BOX 121086, CLERMONT, FL 34712-1086 SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JAN PY 1992 VL 30 BP 1 EP 5 PG 5 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA HD181 UT WOS:A1992HD18100001 ER PT J AU GUNNISON, D BARKO, JW AF GUNNISON, D BARKO, JW TI FACTORS INFLUENCING GAS EVOLUTION BENEATH A BENTHIC BARRIER SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE GAS EVOLUTION; PERMEABILITY; ORGANIC MATTER; SEDIMENT TYPE; COONTAIL AB Laboratory studies were conducted to determine the influences of temperature, sediment type, and sediment organic matter on rates of gas evolution beneath a benthic barrier. Gas evolution was measured at two temperatures (15 and 30 C) from two compositionally distinct (sand and clay) sediments with and without additions of organic matter. Sediments amended by addition of coontail (Ceratophyllum demersum) produced gas at both 15 and 30 C. However, incubation temperature determined both the onset of gas formation and the maximum gas production rate achieved. Results demonstrate that gas evolution begins earlier and gas production rates are greater at warmer temperatures. Examination of the effect of organic matter level on gas evolution rates revealed pronounced increases in gas evolution rates from clay sediments amended by additions of 13 to 130 g of coontail at 30 C. Composition of the gases released proved similar for all of the treatment combinations (nitrogen - 47 to 55 percent; oxygen - 13 to 15 percent; methane - 3 to 4 percent; carbon dioxide - 28 to 36 percent). Based on findings of these studies, benthic barriers scheduled for deployment in areas sustaining high seasonal plant production rates should be emplaced during cooler periods of the year when the standing crop and decomposition rates are low. RP GUNNISON, D (reprint author), USA,ENGINEER WATERWAYS EXPT STN,ENVIRONM LAB,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 11 TC 4 Z9 4 U1 0 U2 1 PU AQUATIC PLANT MANAGEMENT SOC, INC PI CLERMONT PA PO BOX 121086, CLERMONT, FL 34712-1086 SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JAN PY 1992 VL 30 BP 23 EP 28 PG 6 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA HD181 UT WOS:A1992HD18100006 ER PT J AU THOMPSON, IM CHODAK, GW AF THOMPSON, IM CHODAK, GW TI THE NATURAL-HISTORY OF ADENOCARCINOMA OF THE PROSTATE SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Article DE EXPECTANT MANAGEMENT; NATURAL HISTORY; PROSTATE CANCER ID CANCER; CARCINOMA AB All analyses of the efficacy of therapy for prostate cancer must control for the natural history of the disease. Over the past years, several long-term series involving several hundred patients have helped to describe the results of untreated disease. In general, most patients will not die of their disease, although approximately half of the patients will develop disease progression within 10 years. Predictors of progression include tumor stage, grade, and ploidy status. C1 UNIV CHICAGO,SCH MED,DIV UROL,CHICAGO,IL 60637. RP THOMPSON, IM (reprint author), BROOKE ARMY MED CTR,UROL SERV,FT SAM HOUSTON,TX 78234, USA. NR 13 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PY 1992 SU 16H BP 20 EP 25 PG 6 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA KK164 UT WOS:A1992KK16400005 ER PT J AU WILLIAMS, RD BOSTWICK, DG BOONE, CW CATALONA, WJ MCKEEHAN, W THOMPSON, IM AF WILLIAMS, RD BOSTWICK, DG BOONE, CW CATALONA, WJ MCKEEHAN, W THOMPSON, IM TI WHEN IS INTERVENTION WARRANTED SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Editorial Material C1 MAYO CLIN & MAYO FDN,DEPT LAB MED & PATHOL,ROCHESTER,MN 55905. NCI,CHEMOPREVENT BRANCH,BETHESDA,MD 20892. WASHINGTON UNIV,SCH MED,DIV UROL SURG,ST LOUIS,MO 63110. W ALTON JONES CELL SCI CTR,LAKE PLACID,NY 12949. BROOKE ARMY MED CTR,UROL SERV,FT SAM HOUSTON,TX 78234. RP WILLIAMS, RD (reprint author), UNIV IOWA,COLL MED,DEPT UROL,IOWA CITY,IA 52242, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PY 1992 SU 16H BP 138 EP 139 PG 2 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA KK164 UT WOS:A1992KK16400030 ER PT J AU WARREN, RQ NKYA, WMMM SHAO, JF ANDERSON, SA WOLF, H HENDRIX, CW KANDA, P WABUKE, M BOSWELL, RN REDFIELD, RR KENNEDY, RC AF WARREN, RQ NKYA, WMMM SHAO, JF ANDERSON, SA WOLF, H HENDRIX, CW KANDA, P WABUKE, M BOSWELL, RN REDFIELD, RR KENNEDY, RC TI COMPARISON OF ANTIBODY REACTIVITY TO HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) GP160 EPITOPES IN SERA FROM HIV-1-INFECTED INDIVIDUALS FROM TANZANIA AND FROM THE UNITED-STATES SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID NEUTRALIZING ANTIBODIES; ENVELOPE GLYCOPROTEIN; SYNTHETIC PEPTIDES; HTLV-III; EPIDEMIOLOGY; INFECTION; AIDS; SEQUENCE; CHIMPANZEES; ASSOCIATION AB In this study, we compared sera from 159 human immunodeficiency virus type 1 (HIV-1)-infected individuals from Tanzania and 103 infected individuals from the United States for antibodies reactive with 10 HIV-1 gp160 epitopes defined by synthetic peptides. Our data indicate that the anti-gp160 antibody fine specificity differs between infected individuals from these two geographically diverse populations. For example, 50% of the Tanzanian sera contained antibodies reactive with an immunodominant HIV-1 gp41 epitope defined by peptide 600-611, whereas 91% of the sera from the United States were reactive. Differences in serologic reactivity between HIV-1-infected individuals from Tanzania and the United States were also observed with gp160 epitopes defined by peptides 503-528 and 846-860. Included among the peptides examined were four which corresponded to the V3 region of gp120. The majority of sera from either country contained antibodies reactive with peptide RP142, whose V3 sequence is based upon that of HIV-1 isolate MN. Further characterization of serologic reactivity suggested that sera from Tanzania were more likely to neutralize HIV-1 isolate IIIB or MN in vitro than were sera from the United States. These differences in antibody fine specificity between HIV-1-infected individuals from Tanzania and the United States suggest that regional isolates of HIV-1 may exist. C1 SW FDN BIOMED RES,DEPT VIROL & IMMUNOL,SAN ANTONIO,TX 78284. SW FDN BIOMED RES,CTR AIDS RES,SAN ANTONIO,TX 78284. WILFORD HALL USAF MED CTR,DEPT MED,LACKLAND AFB,TX 78236. KILIMANJARO CHRISTIAN MED CTR,MOSHI,TANZANIA. MUHIMBILI MED CTR,DAR ES SALAAM,TANZANIA. BAXTER HEALTHCARE CORP,DUARTE,CA 91010. WALTER REED ARMY MED CTR,DEPT RETROVIRAL RES,ROCKVILLE,MD 20850. RI Hendrix, Craig/G-4182-2014 OI Hendrix, Craig/0000-0002-5696-8665 FU NIAID NIH HHS [AI25151, AI26462, AI28696] NR 32 TC 14 Z9 14 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JAN PY 1992 VL 30 IS 1 BP 126 EP 131 PG 6 WC Microbiology SC Microbiology GA GV355 UT WOS:A1992GV35500020 PM 1370844 ER PT J AU SESTERHENN, IA WEISS, RB MOSTOFI, FK STABLEIN, DM ROWLAND, RG FALKSON, G RIVKIND, SE VOGELZANG, NJ AF SESTERHENN, IA WEISS, RB MOSTOFI, FK STABLEIN, DM ROWLAND, RG FALKSON, G RIVKIND, SE VOGELZANG, NJ TI PROGNOSIS AND OTHER CLINICAL CORRELATES OF PATHOLOGICAL REVIEW IN STAGE-I AND STAGE-II TESTICULAR-CARCINOMA - A REPORT FROM THE TESTICULAR CANCER INTERGROUP STUDY SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Review ID GERM-CELL TUMORS; MULTIVARIATE-ANALYSIS; CHEMOTHERAPY; HISTOPATHOLOGY; PREDICTION; ADJUVANT; RELAPSE C1 WALTER REED ARMY MED CTR,MED ONCOL SECT,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,WASHINGTON,DC 20306. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. EMMES CORP,POTOMAC,MD. INDIANA UNIV,INDIANAPOLIS,IN 46204. SWEDISH HOSP TUMOR INST,SEATTLE,WA. UNIV CHICAGO,CHICAGO,IL 60637. NR 24 TC 108 Z9 110 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD JAN PY 1992 VL 10 IS 1 BP 69 EP 78 PG 10 WC Oncology SC Oncology GA GW592 UT WOS:A1992GW59200012 PM 1309382 ER PT J AU FARLEY, GL JONES, RM AF FARLEY, GL JONES, RM TI CRUSHING CHARACTERISTICS OF CONTINUOUS FIBER-REINFORCED COMPOSITE TUBES SO JOURNAL OF COMPOSITE MATERIALS LA English DT Article DE COMPOSITE MATERIALS; ENERGY ABSORPTION; CRUSHING; MODES; MECHANISMS; TRANSVERSE SHEARING; LAMINA BENDING; LOCAL BUCKLING; BRITTLE FRACTURE ID CRASHWORTHY AB Composite tubes can be reinforced with continuous fibers. When such tubes are subjected to crushing loads, the response is complex and depends on interaction between the different mechanisms that control the crushing process. The modes of crushing and their controlling mechanisms are described. Also, the resulting crushing process and its efficiency are addressed. C1 VIRGINIA POLYTECH INST & STATE UNIV,DEPT ENGN SCI & MECH,BLACKSBURG,VA 24061. RP FARLEY, GL (reprint author), NASA,LANGLEY RES CTR,USA,AVSCOM AEROSTRUCT DIRECTORATE,HAMPTON,VA 23665, USA. NR 14 TC 159 Z9 165 U1 5 U2 12 PU TECHNOMIC PUBL CO INC PI LANCASTER PA 851 NEW HOLLAND AVE, BOX 3535, LANCASTER, PA 17604 SN 0021-9983 J9 J COMPOS MATER JI J. Compos Mater. PY 1992 VL 26 IS 1 BP 37 EP 50 DI 10.1177/002199839202600103 PG 14 WC Materials Science, Composites SC Materials Science GA HC678 UT WOS:A1992HC67800003 ER PT J AU FARLEY, GL JONES, RM AF FARLEY, GL JONES, RM TI ANALOGY FOR THE EFFECT OF MATERIAL AND GEOMETRICAL VARIABLES ON ENERGY-ABSORPTION CAPABILITY OF COMPOSITE TUBES SO JOURNAL OF COMPOSITE MATERIALS LA English DT Article AB Simplified procedures for determining the qualitative effect a variable has on structural response of a composite tube are very useful in both preliminary design as well as in providing insight into the general response. An analysis procedure is presented that can be used to determine the qualitative change in the sustained crushing load due to a change in specimen material properties or geometry. The analysis procedure is similar in form to the equation for the buckling load of a column on an elastic foundation. C1 VIRGINIA POLYTECH INST & STATE UNIV,DEPT ENGN SCI & MECH,BLACKSBURG,VA 24061. RP FARLEY, GL (reprint author), NASA,LANGLEY RES CTR,USA,AVSCOM AEROSTRUCT DIRECTORATE,HAMPTON,VA 23665, USA. NR 3 TC 44 Z9 48 U1 2 U2 5 PU TECHNOMIC PUBL CO INC PI LANCASTER PA 851 NEW HOLLAND AVE, BOX 3535, LANCASTER, PA 17604 SN 0021-9983 J9 J COMPOS MATER JI J. Compos Mater. PY 1992 VL 26 IS 1 BP 78 EP 89 DI 10.1177/002199839202600105 PG 12 WC Materials Science, Composites SC Materials Science GA HC678 UT WOS:A1992HC67800005 ER PT J AU FARLEY, GL JONES, RM AF FARLEY, GL JONES, RM TI PREDICTION OF THE ENERGY-ABSORPTION CAPABILITY OF COMPOSITE TUBES SO JOURNAL OF COMPOSITE MATERIALS LA English DT Article AB A method of predicting the crash-related energy-absorption capability of composite tubes is presented. The method is based upon a phenomenological model of the crushing process exhibited by continuous-fiber-reinforced tubes. A finite element method is used to model the crushing process. The analysis is compared with experiments on Kevlar-epoxy and graphite-epoxy tubes. Reasonable agreement is obtained between the analysis and experiment. C1 VIRGINIA POLYTECH INST & STATE UNIV,DEPT ENGN SCI & MECH,BLACKSBURG,VA 24061. RP FARLEY, GL (reprint author), USA,AVSCOM,AEROSTRUCT DIRECTORATE,LANGLEY RES CTR,HAMPTON,VA 23665, USA. NR 30 TC 55 Z9 56 U1 1 U2 7 PU TECHNOMIC PUBL CO INC PI LANCASTER PA 851 NEW HOLLAND AVE, BOX 3535, LANCASTER, PA 17604 SN 0021-9983 J9 J COMPOS MATER JI J. Compos Mater. PY 1992 VL 26 IS 3 BP 388 EP 404 DI 10.1177/002199839202600304 PG 17 WC Materials Science, Composites SC Materials Science GA HG531 UT WOS:A1992HG53100004 ER PT J AU BOGETTI, TA GILLESPIE, JW AF BOGETTI, TA GILLESPIE, JW TI PROCESS-INDUCED STRESS AND DEFORMATION IN THICK-SECTION THERMOSET COMPOSITE LAMINATES SO JOURNAL OF COMPOSITE MATERIALS LA English DT Article ID RESIDUAL-STRESSES; CURING STRESSES AB A study of process-induced stress and deformation in thick-section thermosetting composite laminates is presented. A methodology is proposed for predicting the evolution of residual stress development during the curing process. A one-dimensional cure simulation analysis is coupled to an incremental laminated plate theory model to study the relationships between complex gradients in temperature and degree of cure, and process-induced residual stress and deformation. Material models are proposed to describe the mechanical properties, thermal and chemical strains of the thermoset resin during cure. These material models are incorporated into a micromechanics model to predict the effective mechanical properties and process-induced strains of the composite during cure. Thermal expansion and cure shrinkage contribute to changes in material specific volume and represent important sources of internal loading included in the analysis. Temperature and degree of cure gradients that develop during the curing process represent fundamental mechanisms that contribute to stress development not considered in traditional residual stress analyses of laminated composites. Model predictions of cure dependent epoxy modulus and curvature in unsymmetric graphite/epoxy laminates are correlated with experimental data. The effects of processing history (autoclave temperature cure cycle), laminate thickness, resin cure shrinkage and laminate stacking sequence on the evolution of process-induced stress and deformation in thick-section glass/polyester and graphite/epoxy laminates during cure are studied. The magnitude of process-induced residual stress is sufficient to initiate transverse cracks and delaminations. The results clearly indicate that the mechanics and performance of thick-section thermoset laminates are strongly dependent on processing history. C1 UNIV DELAWARE,DEPT CHEM ENGN,CTR COMPOSITE MAT,NEWARK,DE 19711. RP BOGETTI, TA (reprint author), USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005, USA. NR 38 TC 212 Z9 228 U1 3 U2 32 PU TECHNOMIC PUBL CO INC PI LANCASTER PA 851 NEW HOLLAND AVE, BOX 3535, LANCASTER, PA 17604 SN 0021-9983 J9 J COMPOS MATER JI J. Compos Mater. PY 1992 VL 26 IS 5 BP 626 EP 660 DI 10.1177/002199839202600502 PG 35 WC Materials Science, Composites SC Materials Science GA HN547 UT WOS:A1992HN54700002 ER PT J AU MORTON, J HO, H TSAI, MY FARLEY, GL AF MORTON, J HO, H TSAI, MY FARLEY, GL TI AN EVALUATION OF THE IOSIPESCU SPECIMEN FOR COMPOSITE-MATERIALS SHEAR PROPERTY MEASUREMENT SO JOURNAL OF COMPOSITE MATERIALS LA English DT Article ID UNIDIRECTIONAL COMPOSITES; MOIRE INTERFEROMETRY; STRESS-ANALYSIS AB A detailed evaluation of the suitability of the Iosipescu specimen tested in the modified Wyoming fixture is presented. A linear finite element model of the specimen is used to assess the uniformity of the shear stress field in the vicinity of the notch, and demonstrate the effect of the nonuniform stress field upon strain gage measurements used for the determination of composite shear moduli. Based upon test results from graphite-epoxy laminates, the proximity of the load introduction point to the test section and the material orthotropy greatly influence the individual gage readings, however, shear modulus determination is not significantly affected by the lack of pure shear. Correction factors are needed to allow for the nonuniformity of the strain field and the use of the average shear stress in the shear modulus evaluation. The correction factors are determined for the region occupied by the strain gage rosette. A comparison of the strain gage readings from one surface of a specimen with corresponding data from moire interferometry on the opposite face documented an extreme sensitivity of some fiber orientations to eccentric loading which induced twisting and spurious shear stress-strain curves. The discovery of specimen twisting explains the apparently inconsistent shear property data found in the literature. Recommendations for improving the reliability and accuracy of the shear modulus values are made, and the implications for shear strength measurement discussed. C1 NASA,LANGLEY RES CTR,USA,AEROSTRUCT DIRECTORATE,HAMPTON,VA 23665. RP MORTON, J (reprint author), VIRGINIA POLYTECH INST & STATE UNIV,DEPT ENGN SCI & MECH,BLACKSBURG,VA 24061, USA. NR 29 TC 67 Z9 67 U1 1 U2 9 PU TECHNOMIC PUBL CO INC PI LANCASTER PA 851 NEW HOLLAND AVE, BOX 3535, LANCASTER, PA 17604 SN 0021-9983 J9 J COMPOS MATER JI J. Compos Mater. PY 1992 VL 26 IS 5 BP 708 EP 750 DI 10.1177/002199839202600505 PG 43 WC Materials Science, Composites SC Materials Science GA HN547 UT WOS:A1992HN54700005 ER PT J AU FARLEY, GL JONES, RM AF FARLEY, GL JONES, RM TI CRUSHING CHARACTERISTICS OF COMPOSITE TUBES WITH NEAR-ELLIPTIC CROSS-SECTIONS SO JOURNAL OF COMPOSITE MATERIALS LA English DT Article ID ENERGY-ABSORPTION AB An experimental investigation was conducted to determine whether the energy-absorption capability of near-elliptical cross-section composite tubular specimens is a function of included angle. Each half of the near-elliptical cross-section tube is a segment of a circle. The included angle is the angle created by radial lines extending from the center of the circular segment to the ends of the circular segment. Graphite- and Kevlar-reinforced epoxy material was used to fabricate specimens. Tube plv orientation was [+/- 45]N where the number of +/- 45 pairs was 2, 4, 6, and 12. Tube internal diameters were 2.54, 3.81, and 7.62 cm, and included angles were 180, 160, 135, 115, and 90 degrees. Based upon the test results from these tubes, energy-absorption capability increased between 10 and 30 percent as included angle decreased between 180 and 90 degrees for the materials evaluated. Energy-absorption capability was a decreasing nonlinear function of the ratio of tube internal diameter to wall thickness. C1 VIRGINIA POLYTECH INST & STATE UNIV,DEPT ENGN SCI & MECH,BLACKSBURG,VA 24061. RP FARLEY, GL (reprint author), USA,AVSCOM,AEROSTRUCT DIRECTORATE,LANGLEY RES CTR,HAMPTON,VA 23665, USA. NR 15 TC 31 Z9 33 U1 1 U2 3 PU TECHNOMIC PUBL CO INC PI LANCASTER PA 851 NEW HOLLAND AVE, BOX 3535, LANCASTER, PA 17604 SN 0021-9983 J9 J COMPOS MATER JI J. Compos Mater. PY 1992 VL 26 IS 12 BP 1741 EP 1751 DI 10.1177/002199839202601203 PG 11 WC Materials Science, Composites SC Materials Science GA JM054 UT WOS:A1992JM05400003 ER PT J AU FARLEY, GL AF FARLEY, GL TI A MECHANISM RESPONSIBLE FOR REDUCING COMPRESSION STRENGTH OF THROUGH-THE-THICKNESS REINFORCED COMPOSITE-MATERIAL SO JOURNAL OF COMPOSITE MATERIALS LA English DT Article AB A study was conducted to identify one of the mechanisms that contributes to the reduced compression strength of composite materials with through-the-thickness (TTT) reinforcements. In this study a series of thick [0/90] laminates with stitched and integrally woven TTT reinforcements were fabricated and statically tested. In both the stitching and weaving process a surface loop of TTT reinforcement yarn is created between successive TTT penetrations. It was shown that the surface loop of the TTT reinforcement "kinked" the in-plane fibers in such a manner that they were made ineffective in carrying compressive load. The improvement in strength by removal of the surface loop and "kinked" in-plane fibers was between 7 and 35 percent. RP FARLEY, GL (reprint author), USA,AVSCOM,AEROSTRUCT DIRECTORATE,LANGLEY RES CTR,HAMPTON,VA 23665, USA. NR 13 TC 16 Z9 17 U1 1 U2 4 PU TECHNOMIC PUBL CO INC PI LANCASTER PA 851 NEW HOLLAND AVE, BOX 3535, LANCASTER, PA 17604 SN 0021-9983 J9 J COMPOS MATER JI J. Compos Mater. PY 1992 VL 26 IS 12 BP 1784 EP 1795 DI 10.1177/002199839202601206 PG 12 WC Materials Science, Composites SC Materials Science GA JM054 UT WOS:A1992JM05400006 ER PT J AU TSANGARAKIS, N PEPI, MS AF TSANGARAKIS, N PEPI, MS TI BIAXIAL FLEXING OF A UNIDIRECTIONALLY REINFORCED ALUMINUM COMPOSITE SO JOURNAL OF COMPOSITE MATERIALS LA English DT Article ID FATIGUE DAMAGE; STRESS; DEFORMATION; BEHAVIOR; TORSION AB Aluminum disks reinforced unidirectionally with silicon carbide continuous fiber were supported circumferentially on one side and loaded at the center of the other side with a pin. Maximal principal tensile surface strains were determined during flexing with strain gages. Failure under monotonic loading initiated on the convex side of the disks with the formation of multiple surface matrix cracks which were parallel to the fibers. These cracks formed soon after matrix yielding which initiated at a strain 0.0015-0.002. On cyclic tensile biaxial flexing, surface matrix cracking was found to be the main failure mechanism. A limited number of disks failed by fiber cracking. The endurance strain limit for 10(7) cycles of life was 0.001. This strain is only 11% of the uniaxial monotonic tensile strain to failure. Ultrasonic velocity scans successfully identified the damage generated during cyclic loading. RP TSANGARAKIS, N (reprint author), USA,MAT TECHNOL LAB,SLCMT MRM,ARSENAL ST,WATERTOWN,MA 02172, USA. NR 28 TC 0 Z9 1 U1 0 U2 2 PU TECHNOMIC PUBL CO INC PI LANCASTER PA 851 NEW HOLLAND AVE, BOX 3535, LANCASTER, PA 17604 SN 0021-9983 J9 J COMPOS MATER JI J. Compos Mater. PY 1992 VL 26 IS 14 BP 2060 EP 2075 DI 10.1177/002199839202601404 PG 16 WC Materials Science, Composites SC Materials Science GA JR989 UT WOS:A1992JR98900004 ER PT J AU JACKSON, KE KELLAS, S MORTON, J AF JACKSON, KE KELLAS, S MORTON, J TI SCALE EFFECTS IN THE RESPONSE AND FAILURE OF FIBER REINFORCED COMPOSITE LAMINATES LOADED IN TENSION AND IN FLEXURE SO JOURNAL OF COMPOSITE MATERIALS LA English DT Article ID STRENGTH; EPOXY; CRACKING AB The feasibility of using scale model testing for predicting the full-scale behavior of flat composite coupons loaded in tension and beam-columns loaded in flexure is examined. Classical laws of similitude are applied to fabricate and test replica model specimens to identify scaling effects in the load response, strength, and mode of failure. Experiments were performed on graphite-epoxy composite specimens having different laminate stacking sequences and a range of scaled sizes. From the experiments it was deduced that the elastic response of scaled composite specimens was independent of size. However, a significant scale effect in strength was observed. In addition, a transition in failure mode was observed among scaled specimens of, certain laminate stacking sequences. A Weibull statistical model and a fracture mechanics based model were applied to predict the strength scale effect since standard failure criteria cannot account for the influence of absolute specimen size on strength. C1 LOCKHEED ENGN & SCI CO,HAMPTON,VA 23666. VIRGINIA POLYTECH INST & STATE UNIV,DEPT ENGN SCI & MECH,BLACKSBURG,VA 24061. RP JACKSON, KE (reprint author), USA,AEROSTRUCTURES DIRECTORATE,AVSCOM,NASA,LANGLEY RES CTR,MAIL STOP 495,HAMPTON,VA 23681, USA. NR 36 TC 35 Z9 35 U1 6 U2 9 PU TECHNOMIC PUBL CO INC PI LANCASTER PA 851 NEW HOLLAND AVE, BOX 3535, LANCASTER, PA 17604 SN 0021-9983 J9 J COMPOS MATER JI J. Compos Mater. PY 1992 VL 26 IS 18 BP 2674 EP 2705 DI 10.1177/002199839202601803 PG 32 WC Materials Science, Composites SC Materials Science GA KG871 UT WOS:A1992KG87100003 ER PT J AU MCGOVERN, TW LITAKER, MS AF MCGOVERN, TW LITAKER, MS TI CLINICAL PREDICTORS OF MALIGNANT PIGMENTED LESIONS - A COMPARISON OF THE GLASGOW 7-POINT CHECKLIST AND THE AMERICAN-CANCER-SOCIETY ABCDS OF PIGMENTED LESIONS SO JOURNAL OF DERMATOLOGIC SURGERY AND ONCOLOGY LA English DT Article ID MELANOMA; RISK; IMPACT; SKIN; NEVI AB Reducing morbidity and mortality from malignant melanoma is the greatest challenge facing dermatology today. We present a comparison of the Glasgow seven-point checklist and the American Cancer Society's ABCDs of pigmented lesions for detecting early melanomas. Logistic regression analysis showed that the Glasgow checklist (N = 205 lesions) contained two significant variables (irregular outline, P = .001, relative odds = 10.9; diameter greater than 1 cm, P = .005, relative odds = 6.7) for differentiating benign from malignant pigmented lesions whereas a three-point version of the ABCDs (N = 192 lesions) had three significant variables (irregular outline, P = .001, relative odds = 9.3; diameter greater than 6 mm, P = .008, relative odds = 5.5; variegation, P = .05, relative odds = 3.7). All six melanomas scored 3 out of 3 on the ABCD scale for a sensitivity of 1.00 and specificity of 0.98 at a threshold of 3 out of 3. Patients rarely sought dermatologic consultation because of these predictors but often sought help for nonsignificant reasons such as inflammation (P = .93), color change (P = .84), itch (P = .72), and increasing size (P = .38). The simpler three-point scale at a threshold of two had equal specificity (0.88 versus 0.94) and better sensitivity (0.73 versus 0.44) than the Glasgow seven-point checklist at the recommended threshold of three out of seven. We therefore recommend that the American public be better educated about the ABCDs to help increase self-referral so that early melanomas can be found and eradicated. C1 DWIGHT D EISENHOWER ARMY MED CTR,DEPT PRIMARY CARE & COMMUN MED,FT GORDON,GA 30905. MED COLL GEORGIA,OFF BIOSTAT,AUGUSTA,GA 30912. NR 22 TC 70 Z9 70 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0148-0812 J9 J DERMATOL SURG ONC PD JAN PY 1992 VL 18 IS 1 BP 22 EP 26 PG 5 WC Oncology; Dermatology; Surgery SC Oncology; Dermatology; Surgery GA HC043 UT WOS:A1992HC04300003 PM 1740563 ER PT J AU JONES, KF AF JONES, KF TI COUPLED VERTICAL AND HORIZONTAL GALLOPING SO JOURNAL OF ENGINEERING MECHANICS LA English DT Article ID TRANSMISSION-LINES AB Galloping can occur when wind blows on ice-coated conductors. In this paper, the linearized coupled vertical-horizontal galloping equations are derived and the eigenvalues defining the motion are determined analytically. The intrinsic coupling between the vertical and horizontal equations requires that there be no vertical motion if the horizontal motion is constrained. Furthermore, vertical galloping may be initiated by a horizontal displacement or velocity. The solution of the eigenvalue equation indicates that the coupled galloping criterion may be either more or less stringent than Den Hartog's criterion. The galloping trajectory is either a straight line at a small angle to the vertical, or under more extreme conditions, defines an elliptical envelope. Solutions are obtained for four cases chosen from the literature to illustrate the effect of different combinations of values of the aerodynamic parameters. RP JONES, KF (reprint author), USA, COLD REG RES & ENGN LAB, 72 LYME RD, HANOVER, NH 03755 USA. NR 26 TC 39 Z9 46 U1 2 U2 10 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9399 EI 1943-7889 J9 J ENG MECH JI J. Eng. Mech. PD JAN PY 1992 VL 118 IS 1 BP 92 EP 107 DI 10.1061/(ASCE)0733-9399(1992)118:1(92) PG 16 WC Engineering, Mechanical SC Engineering GA GW989 UT WOS:A1992GW98900006 ER PT J AU BAUSUM, HT MITCHELL, WR MAJOR, MA AF BAUSUM, HT MITCHELL, WR MAJOR, MA TI BIODEGRADATION OF 2,4-DINITROTOLUENE AND 2,6-DINITROTOLUENE BY FRESH-WATER MICROORGANISMS SO JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-ENVIRONMENTAL SCIENCE AND ENGINEERING & TOXIC AND HAZARDOUS SUBSTANCE CONTROL LA English DT Article DE 2,4-DINITROTOLUENE; 2,6-DINITROTOLUENE; MICROBIAL DEGRADATION; MINERALIZATION AB The microbial degradation of 2,4- and 2,6-dinitrotoluene was complete or nearly complete in surface water from two locations downstream from the Radford Army Ammunition Plant. No degradation was detected in surface water from four local (Frederick, MD area) sites. Either isomer could serve as a sole carbon and energy source, with about 60 percent of substrate carbon appearing as CO2, and with an increase in the population of degrading organisms. In both the rate of mineralization in percent degraded per day increased with increasing substrate concentration. At 10 mg/L, degradation rates of 32 and 14.5 percent/day were observed for the 2,4 and 2,6 isomers, respectively. At very low concentrations of the 2,6 isomer a degrading population did not develop, and significant degradation did not occur. The rate of substrate utilization was far greater, and the lag time shorter, for the 2,4 isomer, consistent with a far greater density of 2,4-DNT degraders. Mixed enrichment cultures were developed for each DNT isomer separately, by sequential transfer to increasing substrate concentrations. Maximum substrate concentrations utilized were about 130 mg/L, and cell yields of 6.8 to 7.3 x 10(5) CFU/mu-g input DNT were calculated. Disappearance of 2,4-DNT in the presence of high concentrations of 2,4-DNT mixed enrichment culture approximated first-order kinetics; pseudo-first order rate constants varied from 0.043 to 0.190 min-1. The mean second-order constant was 3.9 x 10(-10) ml cell-1 min-1. If one assumes a concentration of 10(6) cells/ml, at 25-degrees-C, a half-life of 29.7 hours can be estimated for this isomer. Similarly, for 2,6-DNT, the second-order constant was 9.9 x 10(-10) ml cell-1 min-1. The corresponding estimated half-life was 11.6 hours. This rate is not likely to be realized in natural surface waters, due at least in part to the very low densities of 2,6-DNT utilizers. From mixed enrichment cultures, pure cultures using 2,4-DNT were isolated. RP BAUSUM, HT (reprint author), USA,BIOMED RES & DEV LAB,DIV HLTH EFFECTS RES,FREDERICK,MD 21702, USA. NR 15 TC 16 Z9 17 U1 0 U2 2 PU MARCEL DEKKER INC PI NEW YORK PA 270 MADISON AVE, NEW YORK, NY 10016 SN 1077-1204 J9 J ENVIRON SCI HEAL A JI J. Environ. Sci. Health Part A-Environ. Sci. Eng. Toxic Hazard. Subst. Control PY 1992 VL A27 IS 3 BP 663 EP 695 PG 33 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA HM111 UT WOS:A1992HM11100007 ER PT J AU MART, CJ HENKE, CB AF MART, CJ HENKE, CB TI EMISSIONS FROM THE INCINERATION OF NERVE AGENT ROCKETS CONTAINING LOW-LEVEL PCBS SO JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-ENVIRONMENTAL SCIENCE AND ENGINEERING & TOXIC AND HAZARDOUS SUBSTANCE CONTROL LA English DT Article AB During a recent assessment of the obsolete nerve agent rocket stockpile, some of the shipping and firing tubes encasing the rockets were found to contain low levels of polychlorinated biphenyls (PCBs) within the tube's fiberglass matrix. In order to determine the environmental and regulatory impacts associated with incineration of these rockets, the Army conducted an incineration test in March 1986, using its existing pilot incineration system. Because the feedrate of PCBs to the incinerator was very low and because the background matrix of the stack gas samples was so complex, the approved EPA analytical procedure was not sensitive enough to demonstrate that the PCB emissions were less than the rates required by the Toxic Substances Control Act (TSCA) regulations. While the regulatory level of PCB emissions could not be demonstrated analytically, a health risk assessment based on ambient concentrations of PCBs from dispersion modeling demonstrated that the PCB emissions do not pose a significant health risk. Emissions of octachlorodibenzo-p-dioxin (OCDD) were detected, but the risk assessment found no significant health risk associated with OCDD ambient concentrations. No semivolatile, chlorinated organic compounds were identified in the stack gases, while a number of volatile, chlorinated organic compounds were. Again, no significant health risk was associated with these emissions. C1 USA,ENVIRONM HYG AGCY,ABERDEEN PROVING GROUND,MD 21010. INT TECHNOL CORP,KNOXVILLE,TN. NR 22 TC 0 Z9 0 U1 0 U2 0 PU MARCEL DEKKER INC PI NEW YORK PA 270 MADISON AVE, NEW YORK, NY 10016 SN 1077-1204 J9 J ENVIRON SCI HEAL A JI J. Environ. Sci. Health Part A-Environ. Sci. Eng. Toxic Hazard. Subst. Control PY 1992 VL A27 IS 6 BP 1549 EP 1575 PG 27 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA JD005 UT WOS:A1992JD00500013 ER PT J AU NARAYAN, KA CROSS, ME AF NARAYAN, KA CROSS, ME TI TEMPERATURE INFLUENCE ON ACETYLLYSINE INTERACTION WITH GLUCOSE IN MODEL SYSTEMS DUE TO MAILLARD REACTION SO JOURNAL OF FOOD SCIENCE LA English DT Article DE BROWNING; MAILLARD-REACTION; GLUCOSE; ACETYLLYSINE; CELLULOSE ID PROTEIN-QUALITY CHANGE; AVAILABLE LYSINE; WATER ACTIVITY; DEHYDRATED CABBAGE; KINETICS; STORAGE; OVALBUMIN; LACTOSE; LOSSES; FLOUR AB The interaction between N-alpha-acetyllysine and glucose was investigated in a dry cellulose matrix (1.8% moisture) at 40, 50 and 60-degrees-C and a(w) 0.19-0.21. The loss in acetyllysine in 6 days at those temperatures was 22, 54, and 79%, respectively. The degradation data more clearly fit a double exponential function (Ae(BX) + Ce(DX)) than the first order function, Ae(BX). An estimate of the activation energy of 36 kcal/mol and a Q10 of 5.5 was computed from second order rate constants for acetyllysine and glucose degradation. The increase in color followed zero order kinetics and indicated an activation energy of 44 kcal/mol for the presumed third phase of the Maillard reaction in the solid state. C1 LETTERMAN ARMY INST RES,DIV BLOOD RES,SAN FRANCISCO,CA 94129. RP NARAYAN, KA (reprint author), USA,CTR RES DEV & ENGN,FOOD ENGN DIRECTORATE,DIV TECHNOL ACQUISIT,NATICK,MA 01760, USA. NR 53 TC 6 Z9 6 U1 0 U2 1 PU INST FOOD TECHNOLOGISTS PI CHICAGO PA SUITE 300 221 N LASALLE ST, CHICAGO, IL 60601-1291 SN 0022-1147 J9 J FOOD SCI JI J. Food Sci. PD JAN-FEB PY 1992 VL 57 IS 1 BP 206 EP 212 DI 10.1111/j.1365-2621.1992.tb05457.x PG 7 WC Food Science & Technology SC Food Science & Technology GA HD555 UT WOS:A1992HD55500048 ER PT J AU FLINN, LL AF FLINN, LL TI COLLECTION OF FIBER EVIDENCE USING A ROLLER DEVICE AND ADHESIVE LIFTS SO JOURNAL OF FORENSIC SCIENCES LA English DT Article DE CRIMINALISTICS; FIBERS; ADHESIVE TAPES; FIBER EVIDENCE; FIBER COLLECTION; TAPE LIFTS; ADHESIVE LIFTS; LIFT PREPARATION APPARATUS; ROLLER COLLECTION DEVICE AB The potential for transfer of fiber evidence during the commission of a crime and the use of such evidence in criminal investigations have been well established. One of the accepted methods for collection of fiber evidence is the use of adhesive lifts, generally adhesive tape. A procedure is described for the preparation of adhesive lifts and for a roller device with which these lifts are employed. Use of the roller and lifts can substantially reduce the time associated with the collection of fiber evidence from clothing, bedding, and other items in the laboratory and at crime scenes. C1 USA,CONUS,CRIMINAL INVEST LAB,FOREST PK,GA 30050. NR 7 TC 6 Z9 7 U1 1 U2 7 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD JAN PY 1992 VL 37 IS 1 BP 106 EP 112 PG 7 WC Medicine, Legal SC Legal Medicine GA JY402 UT WOS:A1992JY40200012 ER PT J AU ALLEN, AC STEVENSON, ML NAKAMURA, SM ELY, RA AF ALLEN, AC STEVENSON, ML NAKAMURA, SM ELY, RA TI DIFFERENTIATION OF ILLICIT PHENYL-2-PROPANONE SYNTHESIZED FROM PHENYLACETIC ACID WITH ACETIC-ANHYDRIDE VERSUS LEAD (II) ACETATE SO JOURNAL OF FORENSIC SCIENCES LA English DT Article DE TOXICOLOGY; PHENYL-2-PROPANONE; CLANDESTINE DRUG LABORATORIES; REACTION BY-PRODUCTS; REACTION MECHANISM; SIGNATURE COMPOUNDS; METHAMPHETAMINE; AMPHETAMINE ID KETONES AB The illicit synthesis of phenyl-2-propanone (P2P) in clandestine drug laboratories from phenylacetic acid and acetic anhydride in the presence of sodium acetate or pyridine, or from the dry distillation of phenylacetic acid and lead (II) acetate is examined. These two routes are investigated using capillary gas chromatography (GC) combined with vapor-phase Fourier transform infrared (FTIR) spectroscopy and electron impact mass spectrometry (EIMS) detection (GC-FTIR-EIMS), and using nuclear magnetic resonance (NMR) spectroscopy to identify 21 reaction by-products. The mechanisms of the two reactions producing P2P are presented, along with the mechanisms giving rise to these by-products. This investigation has identified 4 reaction-specific compounds which can be used to differentiate the two synthetic methods. C1 US DRUG ENFORCEMENT ADM,WESTERN LAB,SAN FRANCISCO,CA 94105. WALTER REED ARMY INST RES,DIV BIOCHEM,WASHINGTON,DC 20307. NR 55 TC 10 Z9 10 U1 1 U2 4 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD JAN PY 1992 VL 37 IS 1 BP 301 EP 322 PG 22 WC Medicine, Legal SC Legal Medicine GA JY402 UT WOS:A1992JY40200030 ER PT J AU ALBERT, MR MCGILVARY, WR AF ALBERT, MR MCGILVARY, WR TI THERMAL EFFECTS DUE TO AIR-FLOW AND VAPOR TRANSPORT IN DRY SNOW SO JOURNAL OF GLACIOLOGY LA English DT Article AB The thermal effects of air flow forced through a snow sample are investigated numerically. A new method for calculating vapor transport in snow is presented which allows for the determination of the effects of sublimation. In this method, the snow is not assumed to be saturated with water vapor. Results of the model show very good agreement with analytical and experimental results. The effects of heat conduction, heat advected by the dry air and heat associated with sublimation are examined in a comprehensive theory, and then each effect is isolated to determine its overall contribution. It is demonstrated that the heat transfer associated with vapor transport is significant in the determination of the overall temperature profile of a ventilated snow sample but that the major effects are controled by the heat carried by the dry air flow through the snow and heat conduction due to the temperatures imposed at the boundaries. The thermal effects of ventilation of snow are more likely to be observed when there is a smaller temperature gradient over the entire snowpack and a greater flow rate of air in the snow than would be observed when there is a greater overall temperature gradient and lesser air-flow rate. RP ALBERT, MR (reprint author), USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 21 TC 40 Z9 41 U1 1 U2 2 PU INT GLACIOL SOC PI CAMBRIDGE PA LENSFIELD RD, CAMBRIDGE, ENGLAND CB2 1ER SN 0022-1430 J9 J GLACIOL JI J. Glaciol. PY 1992 VL 38 IS 129 BP 273 EP 281 PG 9 WC Geography, Physical; Geosciences, Multidisciplinary SC Physical Geography; Geology GA JP175 UT WOS:A1992JP17500007 ER PT J AU KOVACS, A AF KOVACS, A TI ICE-BLISTER OBSERVATIONS ON GLACIERS, SEA ICE AND RIVERS SO JOURNAL OF GLACIOLOGY LA English DT Letter RP KOVACS, A (reprint author), USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 15 TC 2 Z9 2 U1 0 U2 0 PU INT GLACIOL SOC PI CAMBRIDGE PA LENSFIELD RD, CAMBRIDGE, ENGLAND CB2 1ER SN 0022-1430 J9 J GLACIOL JI J. Glaciol. PY 1992 VL 38 IS 129 BP 314 EP 315 PG 2 WC Geography, Physical; Geosciences, Multidisciplinary SC Physical Geography; Geology GA JP175 UT WOS:A1992JP17500012 ER PT J AU DALY, SF AF DALY, SF TI OBSERVED ICE PASSAGE FROM LAKE HURON INTO THE ST-CLAIR RIVER SO JOURNAL OF GREAT LAKES RESEARCH LA English DT Article DE ICE; ICE REPORTING; ST-CLAIR RIVER; GREAT LAKES; ICE FORMATION; ICE JAMS AB Ice entering the St. Clair River from southern Lake Huron has caused large ice jams on the river, which have inundated large inhabited areas and delayed navigation. Study and forecasting of these ice jam events require that the ice passage from the lake into the river be described quantitatively. This paper analyzes data obtained from time-lapse photography of ice conditions at the entrance of the river at Lake Huron over six winters. For each day of record when ice was observed in Lake Huron or the river, the presence or absence of an ice arch and the daily average surface concentration of ice entering the river were noted. For the months of January through April, separate means, standard deviations, and distributions of the surface ice concentration were determined for periods when the ice arch was present or absent. The existence of the ice arch can be predicted by a simple indicator based on air temperature. The statistical distributions of ice concentration are strongly influenced by the presence or absence of the ice arch. The overall mean surface ice concentration was 9.5% with an arch present and 27.3% with no arch. Based on this finding, ice passage can be forecasted. RP DALY, SF (reprint author), USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 8 TC 5 Z9 5 U1 0 U2 0 PU INT ASSOC GREAT LAKES RES PI ANN ARBOR PA 2200 BONISTEEL BLVD, ANN ARBOR, MI 48109-2099 SN 0380-1330 J9 J GREAT LAKES RES JI J. Gt. Lakes Res. PY 1992 VL 18 IS 1 BP 61 EP 69 PG 9 WC Environmental Sciences; Limnology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA HP681 UT WOS:A1992HP68100007 ER PT J AU KUBIK, HE AF KUBIK, HE TI ANNUAL EXTREME LAKE ELEVATIONS BY TOTAL PROBABILITY THEOREM SO JOURNAL OF GREAT LAKES RESEARCH LA English DT Article DE LAKE STAGES; FREQUENCY ANALYSIS; PROBABILITY AB Annual extreme water levels on the Great Lakes, whether maximums or minimums, have a high serial dependence. Therefore, traditional frequency analysis techniques are not applicable and more sophisticated statistical techniques are required to account for the dependence in the annual extremes. Decomposition of the annual extremes into two parts, one containing the highly dependent part and the other containing the random part, is one method of dealing with the dependence in the lake elevations. These parts are then combined by application of the total probability theorem. Seasonality of the occurrence of both parts was found to be very important. Therefore, the complete analysis was done for the 6-month fall-winter period and the 6-month spring-summer period. The two curves were then combined by the union of probabilities. Application of this method to the Buffalo Harbor and Cleveland gages resulted in computed "1% of Years Exceeded" elevations of 176.76 meters (579.91 feet) and 175.17 meters (574.71 feet) (IGLD 1955), respectively. RP KUBIK, HE (reprint author), USA,CTR HYDROL ENGN,609 2ND ST,DAVIS,CA 95616, USA. NR 3 TC 1 Z9 1 U1 1 U2 1 PU INT ASSOC GREAT LAKES RES PI ANN ARBOR PA 2200 BONISTEEL BLVD, ANN ARBOR, MI 48109-2099 SN 0380-1330 J9 J GREAT LAKES RES JI J. Gt. Lakes Res. PY 1992 VL 18 IS 1 BP 202 EP 206 PG 5 WC Environmental Sciences; Limnology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA HP681 UT WOS:A1992HP68100019 ER PT J AU ACHTMAN, M KUSECEK, B MORELLI, G EICKMANN, K WANG, JF CROWE, B WALL, RA HASSANKING, M MOORE, PS ZOLLINGER, W AF ACHTMAN, M KUSECEK, B MORELLI, G EICKMANN, K WANG, JF CROWE, B WALL, RA HASSANKING, M MOORE, PS ZOLLINGER, W TI A COMPARISON OF THE VARIABLE ANTIGENS EXPRESSED BY CLONE-IV-1 AND SUBGROUP-III OF NEISSERIA-MENINGITIDIS SEROGROUP-A SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID WHOLE-CELL ELISA; MENINGOCOCCAL DISEASE; MONOCLONAL-ANTIBODIES; EPIDEMIC; VACCINATION; EPITOPES; LIPOPOLYSACCHARIDE; GONORRHOEAE; CARRIAGE; BLOCKING AB Serogroup A Neisseria meningitidis of subgroup III has caused two pandemics of meningococcal meninigitis since 1966 and recently spread to East Africa. The last epidemics in West Africa in the early 1980s were caused by clone IV-1. Surface antigens of clone IV-1 strains from West Africa and subgroup III strains from both pandemic waves were analyzed. Lipopolysaccharide was stable within clone IV-1 but variable in subgroup III. Pili from clone IV-1 possessed class I epitopes, while those from subgroup III also possessed class IIa epitopes. Certain class 5 protein variants were expressed by both bacterial clones, possibly reflecting either inheritance of primeval genes or horizontal transmission. Exposure of Gambians to clone IV-1 bacteria stimulated production of bactericidal antibodies cross-reactive with subgroup III bacteria in some individuals but of type-specific antibodies in others. Gambians without bactericidal antibodies usually became healthy carriers rather than developing meningococcal disease on exposure to virulent meningococci. C1 MRC,FAJARA,SENEGAMBIA. CTR DIS CONTROL,MENINGITIS & SPECIAL PATHOGENS BRANCH,ATLANTA,GA 30333. WALTER REED ARMY MED CTR,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. RP ACHTMAN, M (reprint author), MAX PLANCK INST MOLEC GENET,IHNESTR 73,W-1000 BERLIN 33,GERMANY. RI Moore, Patrick/F-3960-2011; OI Moore, Patrick/0000-0002-8132-858X; Achtman, Mark/0000-0001-6815-0070 NR 50 TC 65 Z9 67 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JAN PY 1992 VL 165 IS 1 BP 53 EP 68 PG 16 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA GW582 UT WOS:A1992GW58200007 PM 1370175 ER PT J AU ECHEVERRIA, P SERICHANTALERG, O CHANGCHAWALIT, S BAUDRY, B LEVINE, MM ORSKOV, F ORSKOV, I AF ECHEVERRIA, P SERICHANTALERG, O CHANGCHAWALIT, S BAUDRY, B LEVINE, MM ORSKOV, F ORSKOV, I TI TISSUE CULTURE-ADHERENT ESCHERICHIA-COLI IN INFANTILE DIARRHEA SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID HEP-2 CELLS; DIFFUSE ADHERENCE; HELA-CELLS; SEROTYPES; PATTERNS; STRAINS AB To determine the association of tissue culture-adherent EscIherichia coli with diarrhea, serotyped E. coli strains isolated in a yearlong case-control study of infantile diarrhea in Bangkok, Thailand, were examined for adherence to HeLa cells and for hybridization with the enteropathogenic E. coli adherence factor, the F1845, and the enteroaggregative E. coli (EAggEC) DNA probes. E. coli that adhered to HeLa cells in a localized adherence (LA) pattern (LA E. coli) was isolated from 26 of 509 infants with diarrhea (cases) and 9 of 509 age-matched controls (P = .006); E. coli with diffuse or aggregative adherence (DA or AA) to HeLa cells or that hybridized with the F1845 or EAggEC probes was not associated with infantile diarrhea. LA E. coli of classical enteropathogenic E. coli (EPEC) serotypes was isolated from 11 cases and 1 control (P = .003). EPEC O44: H18 that adhered to HeLa cells in a DA pattern and hybridized with the F1845 DNA probe was the predominant E. coli (five of five colonies tested) isolated from a 5-month-old girl with diarrhea in whom no other enteric infections were identified. Although LA E. coli was highly associated with infantile diarrhea, the role of DA and AA E. coli was uncertain in this setting. C1 ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. UNIV MARYLAND,DIV GEOG MED,BALTIMORE,MD 21201. SERUMINST,ESCHERICHIA & KLEBSIELLA REFERENCE CTR,COPENHAGEN,DENMARK. NR 15 TC 50 Z9 50 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JAN PY 1992 VL 165 IS 1 BP 141 EP 143 PG 3 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA GW582 UT WOS:A1992GW58200019 PM 1727883 ER PT J AU ECHEVERRIA, P SETHABUTR, O SERICHANTALERGS, O LEXOMBOON, U TAMURA, K AF ECHEVERRIA, P SETHABUTR, O SERICHANTALERGS, O LEXOMBOON, U TAMURA, K TI SHIGELLA AND ENTEROINVASIVE ESCHERICHIA-COLI INFECTIONS IN HOUSEHOLDS OF CHILDREN WITH DYSENTERY IN BANGKOK SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID DNA; AMPLIFICATION; POLYMERASE; THAILAND; FLEXNERI AB Shigellae and enteroinvasive Escherichia coli (EIEC) were identified in children with dysentery and their household contacts in Bangkok. Shigellae were isolated from 49% and EIEC from 6% of 306 children with dysentery seen at the outpatient department of Children's Hospital on weekdays during January through June 1989 and October 1989 through October 1990. The same serotype infecting the index child was isolated from 21 (4%) of 522 household contacts of 151 index children with Shigella infections and from none of 60 household contacts of 19 index children with EIEC infections. Amplification of DNA sequences coding for the invasion-associated locus (ial) by polymerase chain reaction increased the identification of Shigella and EIEC infections from 57% (111/193) to 68% (132/193). ial sequences were identified in 3 of 20 drinking water specimens from which shigellae or EIEC were not isolated. Amplification of ial sequences identified more shigellae and EIEC than did bacteriologic and colony hybridization methods in children with dysentery and in drinking water in Bangkok. C1 CHILDRENS HOSP,ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. NATL INST HLTH,TOKYO 141,JAPAN. NR 12 TC 37 Z9 38 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JAN PY 1992 VL 165 IS 1 BP 144 EP 147 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA GW582 UT WOS:A1992GW58200020 PM 1727884 ER PT J AU MALONE, JL OLDFIELD, EC WAGNER, KF SIMMS, TE DALY, R OBRIAN, J BURKE, DS AF MALONE, JL OLDFIELD, EC WAGNER, KF SIMMS, TE DALY, R OBRIAN, J BURKE, DS TI ABNORMALITIES OF MORNING SERUM CORTISOL-LEVELS AND CIRCADIAN-RHYTHMS OF CD4+ LYMPHOCYTE COUNTS IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1-INFECTED ADULT PATIENTS SO JOURNAL OF INFECTIOUS DISEASES LA English DT Letter ID ENDOCRINE ABNORMALITIES; INFECTION; HIV; SUBSETS C1 USN HOSP, DEPT INTERNAL MED, SAN DIEGO, CA 92134 USA. NATL NAVAL MED CTR, DEPT INTERNAL MED, BETHESDA, MD 20814 USA. WALTER REED ARMY MED CTR, WASHINGTON, DC 20307 USA. RP MALONE, JL (reprint author), USN HOSP, DEPT CLIN INVEST, SAN DIEGO, CA 92134 USA. OI /0000-0002-5704-8094 NR 10 TC 13 Z9 14 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JAN PY 1992 VL 165 IS 1 BP 185 EP 186 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA GW582 UT WOS:A1992GW58200036 PM 1345795 ER PT J AU PRUEITT, GC PARK, CS AF PRUEITT, GC PARK, CS TI THE ECONOMIC JUSTIFICATION OF THE SEQUENTIAL ADOPTION OF A NEW MANUFACTURING SYSTEM SO JOURNAL OF MANUFACTURING SYSTEMS LA English DT Article AB Corporations in the US are showing a growing interest in the use of advanced technologies. They realize that to compete in today's world market, they must rely on the latest innovations in manufacturing technology. Techniques such as computer-aided design and computer-aided manufacturing, along with computer-controlled manufacturing equipment, are being introduced into computer-integrated manufacturing (CIM) and production systems. These advanced systems have great potential for improving manufacturing performance, but there is still a considerable gap between the decision to invest and the achievement of the promised benefits. The implementation of CIM normally entails a large initial investment under a long-term, uncertain environment. Many companies, generally, cannot afford this investment unless they can determine beforehand that CIM will work in their particular industry and that it will provide a coherent manufacturing strategy and a satisfactory return on investment. In many cases, it is even impossible to economically justify CIM if the benefits are achieved only after complete implementation. In this paper, we discuss ways to achieve CIM in progressive steps (a pay-as-you-go approach), beginning with a simple configuration and working up to a full configuration, as appropriate. In this way, partial benefits of CIM are reaped with each stage, and, at the minimum risk, successive steps are clearly justified in terms of the firm's objectives. We develop a decision tool that uses post-audit information to resolve the uncertainty about the expected net present value of a technically innovative process. The method was applied to an actual CIM project to document the economic justification steps. RP PRUEITT, GC (reprint author), USA,FT LEAVENWORTH,KS 66027, USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU SOC MANUFACTURING ENGINEERS PI DEARBORN PA ONE SME DRIVE, PO BOX 930, DEARBORN, MI 48121-0930 SN 0278-6125 J9 J MANUF SYST JI J. Manuf. Syst. PY 1992 VL 11 IS 1 BP 38 EP 49 DI 10.1016/0278-6125(92)90016-9 PG 12 WC Engineering, Industrial; Engineering, Manufacturing; Operations Research & Management Science SC Engineering; Operations Research & Management Science GA HJ004 UT WOS:A1992HJ00400006 ER PT J AU TURELL, MJ BEAMAN, JR TAMMARIELLO, RF AF TURELL, MJ BEAMAN, JR TAMMARIELLO, RF TI SUSCEPTIBILITY OF SELECTED STRAINS OF AEDES-AEGYPTI AND AEDES-ALBOPICTUS (DIPTERA, CULICIDAE) TO CHIKUNGUNYA VIRUS SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE INSECTA; AEDES SPP; CHIKUNGUNYA VIRUS; INFECTION RATES ID VALLEY FEVER VIRUS; CULEX-PIPIENS; INFECTION; MOSQUITO AB The relative susceptibility of selected strains of Aedes aegypti (L.) and Aedes albopictus (Skuse) fed on a viremic monkey to infection with chikungunya virus was determined. Infection rates were consistently higher in 10 strains of Ae. albopictus tested than in 7 strains of Ae. aegypti tested, regardless of the geographic location from which the strains originated or the dose of virus ingested. Similarly, virus dissemination rates were higher in the Ae. albopictus strains compared with the Ae. aegypti strains. For nearly all (11 of 12) strains tested of both species, groups of mosquitoes with one or more females with a disseminated infection transmitted virus by bite to weanling mice. Based on these studies, Ae. albopictus appears to be a more competent laboratory vector of chikungunya virus than does Ae. aegypti. RP TURELL, MJ (reprint author), USA,MED RES INST INFECT DIS,DIV VIROL,FT DETRICK,MD 21702, USA. NR 18 TC 62 Z9 65 U1 1 U2 5 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD JAN PY 1992 VL 29 IS 1 BP 49 EP 53 PG 5 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA GW982 UT WOS:A1992GW98200010 PM 1313111 ER PT J AU AMERASINGHE, FP BREISCH, NL AZAD, AF GIMPEL, WF GRECO, M NEIDHARDT, K PAGAC, B PIESMAN, J SANDT, J SCOTT, TW SWEENEY, K AF AMERASINGHE, FP BREISCH, NL AZAD, AF GIMPEL, WF GRECO, M NEIDHARDT, K PAGAC, B PIESMAN, J SANDT, J SCOTT, TW SWEENEY, K TI DISTRIBUTION, DENSITY, AND LYME-DISEASE SPIROCHETE INFECTION IN IXODES-DAMMINI (ACARI, IXODIDAE) ON WHITE-TAILED DEER IN MARYLAND SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE ACARI; LYME DISEASE; DEER; MARYLAND ID BORRELIA-BURGDORFERI; BABESIA-MICROTI; NORTH-CAROLINA; TICKS; PREVALENCE; USA; WISCONSIN; ANTIBODY; VECTOR; MAINE AB A Statewide survey of ticks parasitizing white-tailed deer was carried out in Maryland during November 1989 to assess the status of the deer tick, Ixodes dammini Spielman, Clifford, Piesman & Corwin, the major vector of Lyme disease in the northeastern United States. Ticks were collected from deer carcasses brought in by hunters at 23 check stations (one per county). A total of 3,437 I. dammini were collected from 538 of 1,281 deer (42%), together with 2,013 Dermacentor albipictus (Packard) and 23 Amblyomma americanum (L.) from 34 and 0.5% of deer respectively. I. dammini prevalence ranged from 0 to 79% of deer and mean abundance from 0 to 7.3 ticks per deer at different check stations. Lyme spirochete, Borrelia burgdorferi Johnson, Schmid, Hyde, Steigerwalt & Brenner, infection rates in ticks ranged from 0 to 21%, with a mean of 8%. Deer-tick density and spirochete infection rates varied with physiographic region and were low in the Appalachian, intermediate in the Piedmont, and high in the Western and Eastern Coastal Plains regions. County-based human case rates correlated positively with I. dammini abundance. We concluded that I. dammini was well established except in the mountainous western region of Maryland and was involved in Lyme disease transmission. C1 UNIV MARYLAND,DEPT ENTOMOL,COLLEGE PK,MD 20742. UNIV MARYLAND,SCH MED,DEPT MICROBIOL & IMMUNOL,BALTIMORE,MD 21201. MARYLAND DEPT AGR,PLANT PROTECT SECT,ANNAPOLIS,MD 21401. MARYLAND DEPT HLTH & MENTAL HYG,BALTIMORE,MD 21201. USA,ENVIRONM HYG ACTIV N,DIV ENTOMOL SCI,FT GEORGE,MD 20755. CTR DIS CONTROL,DIV VECTOR BORNE INFECT DIS,FT COLLINS,CO 80522. MARYLAND DEPT NAT RESOURCES,WYE MILLS,MD 21679. NR 30 TC 40 Z9 40 U1 0 U2 4 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD JAN PY 1992 VL 29 IS 1 BP 54 EP 61 PG 8 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA GW982 UT WOS:A1992GW98200011 PM 1552529 ER PT J AU TURELL, MJ LUDWIG, GV BEAMAN, JR AF TURELL, MJ LUDWIG, GV BEAMAN, JR TI TRANSMISSION OF VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS BY AEDES-SOLLICITANS AND AEDES-TAENIORHYNCHUS (DIPTERA, CULICIDAE) SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE INSECTA; AEDES-SOLLICITANS; AEDES-TAENIORHYNCHUS; VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS ID VALLEY FEVER VIRUS; CULEX-PIPIENS; ENCEPHALITIS; HOST AB Experimental studies compared the vector competence of Aedes sollicitans (Skuse) and Ae. taeniorhynchus (Wiedemann) collected on Assateague Island, Va., for an epizootic strain (Trinidad donkey) of Venezuelan equine encephalomyelitis (VEE) virus. Infection rates were significantly higher in Ae. sollicitans (101/107, 94%) than in Ae. taeniorhynchus (103/175, 59%), even though both species fed concurrently on the same infected hamsters. Similarly, dissemination and transmission rates were significantly higher in the Ae. sollicitans population tested. Although both Ae. taeniorhynchus and Ae. sollicitans are natural vectors of VEE virus, the latter species should be considered a more efficient vector of VEE epizootic strains, based on its greater susceptibility to infection and higher transmission rates.. RP TURELL, MJ (reprint author), USA,MED RES INST INFECT DIS,DIV VIROL,FREDERICK,MD 21702, USA. NR 13 TC 24 Z9 24 U1 0 U2 1 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD JAN PY 1992 VL 29 IS 1 BP 62 EP 65 PG 4 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA GW982 UT WOS:A1992GW98200012 PM 1552530 ER PT J AU DURDEN, LA LINTHICUM, KJ TURELL, MJ AF DURDEN, LA LINTHICUM, KJ TURELL, MJ TI MECHANICAL TRANSMISSION OF VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS BY HEMATOPHAGOUS MITES (ACARI) SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Note DE ARACHNIDA; VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS; MECHANICAL TRANSMISSION; MITES ID OECIACUS-VICARIUS AB Studies were undertaken to determine whether two species of hematophagous mites could transmit Venezuelan equine encephalomyelitis (VEE) virus to suckling mice. The chicken mite, Dermanyssus gallinae (De Geer), mechanically transmitted this virus to previously uninfected mice up to 16 h after taking a blood meal from a viremic animal. In contrast, Laelaps kochi Oudemans failed to transmit virus to mice in any feeding trials. Virus did not replicate in either species of mite but was detected in 20% of D. gallinae and in 12% of L. kochi specimens tested 48 h after a viremic blood meal. In mites inoculated intracoelomically with virus, recovery rates declined over time, but virus was detected up to 7 d later in 5% of D. gallinae and up to 3 d later in 10% of L. kochi. Biological transmission of VEE virus was not demonstrated in either species of mite. RP DURDEN, LA (reprint author), USA,MED RES INST INFECT DIS,DIV VIROL,DEPT ARBOVIRAL ENTOMOL,FREDERICK,MD 21702, USA. NR 17 TC 18 Z9 18 U1 0 U2 0 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD JAN PY 1992 VL 29 IS 1 BP 118 EP 121 PG 4 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA GW982 UT WOS:A1992GW98200021 PM 1552519 ER PT J AU MUNN, EM SAULSBERY, PAH AF MUNN, EM SAULSBERY, PAH TI FACILITY PLANNING - A BLUEPRINT FOR NURSE EXECUTIVES SO JOURNAL OF NURSING ADMINISTRATION LA English DT Article AB Nurse executives have a critical role to ensure that facility planning will meet the needs of patients and make effective use of nursing personnel. The authors discuss the stages of the facility planning process. A detailed checklist assists nurse executives involved in facility remodeling, expansion, retrofitting, and new construction projects. C1 USA,NURSE CORPS,FALLS CHURCH,VA. RP MUNN, EM (reprint author), USA,NURSE CORPS,FACIL PLANNING LIAISON,WOMACK ARMY MED CTR,FT BRAGG,NC, USA. NR 19 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0002-0443 J9 J NURS ADMIN JI J. Nurs. Adm. PD JAN PY 1992 VL 22 IS 1 BP 13 EP 17 DI 10.1097/00005110-199201000-00018 PG 5 WC Nursing SC Nursing GA HA819 UT WOS:A1992HA81900003 PM 1729447 ER PT J AU RUNGEE, JL REINKER, KA AF RUNGEE, JL REINKER, KA TI OSSIFIC NUCLEUS ECCENTRICITY IN CONGENITAL DISLOCATION OF THE HIP SO JOURNAL OF PEDIATRIC ORTHOPAEDICS LA English DT Article DE CONGENITAL DISLOCATION OF THE HIP; ECCENTRICITY; OSSIFIC NUCLEUS AB We studied plain films, arthrograms, and clinical courses of patients with congenital dislocation of the hip to examine the relationship of ossific nucleus eccentricity (ONE) of the femoral head to the shape of the cartilaginous femoral head and the prognosis of these findings. No statistically significant correlation of ONE and cartilaginous femoral head shape was noted, nor was correlation noted for early femoral head shape and subsequent clinical course. Only the association of ONE in an older subgroup of patients with a complicated clinical course was statistically significant (p < 0.05). C1 TRIPLER ARMY MED CTR,ORTHOPAED SURG SERV,HONOLULU,HI 96859. NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0271-6798 J9 J PEDIATR ORTHOPED JI J. Pediatr. Orthop. PD JAN-FEB PY 1992 VL 12 IS 1 BP 61 EP 67 PG 7 WC Orthopedics; Pediatrics SC Orthopedics; Pediatrics GA GY180 UT WOS:A1992GY18000010 PM 1732296 ER PT J AU WINSLOW, R VARGHESE, A NOBLE, D DENYER, JC KIMBALL, A AF WINSLOW, R VARGHESE, A NOBLE, D DENYER, JC KIMBALL, A TI MODELING LARGE SA NODE-ATRIAL CELL NETWORKS ON A MASSIVELY PARALLEL COMPUTER SO JOURNAL OF PHYSIOLOGY-LONDON LA English DT Meeting Abstract ID RABBIT SINUS NODE C1 UNIV MINNESOTA,DEPT PHYSIOL,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,USA,HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55455. NR 4 TC 6 Z9 6 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 40 WEST 20TH STREET, NEW YORK, NY 10011-4211 SN 0022-3751 J9 J PHYSIOL-LONDON JI J. Physiol.-London PY 1992 VL 446 BP P242 EP P242 PG 1 WC Neurosciences; Physiology SC Neurosciences & Neurology; Physiology GA HD605 UT WOS:A1992HD60500237 ER PT J AU GARY, JJ JOHNSON, AC GARNER, FT AF GARY, JJ JOHNSON, AC GARNER, FT TI THE ROLE OF THE PROSTHODONTIST REGARDING ASPIRATIVE DYSPHAGIA SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article ID PNEUMONITIS; DISORDERS; PATIENT; DISEASE; HEAD AB Certain swallowing disorders characteristically may follow head and neck surgeries and neurologic disorders. Aspiration is one of the possible symptoms of dysphagia. Since aspiration can be life-threatening, prosthodontists should help to identify patients who aspirate. This article describes the normal swallowing physiology, the pathophysiology of swallowing disorders, and the prosthetic role in the treatment of patients experiencing head and neck surgical operations and neurologic disorders that may cause aspiration. C1 USA,WILLIAM BEAUMONT ARMY MED CTR,EL PASO,TX. MEM MED CANC CARE CTR,TULSA,OK. NR 24 TC 1 Z9 1 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD JAN PY 1992 VL 67 IS 1 BP 101 EP 106 DI 10.1016/0022-3913(92)90058-I PG 6 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA GZ690 UT WOS:A1992GZ69000023 PM 1548591 ER PT J AU BLOODWORTH, KE RENDER, PJ AF BLOODWORTH, KE RENDER, PJ TI DENTAL ACRYLIC RESIN RADIOPACITY - LITERATURE-REVIEW AND SURVEY OF PRACTITIONERS ATTITUDES SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Review ID DENTURE AB This study was initiated to ascertain the existence and some specifics of medical problems caused by traumatic ingestion/aspiration of fragments of radiolucent dental prostheses, and to evaluate opinions of radiopacity inclusion. A survey of 50 United States departments of oral surgery and emergency medicine yielded a 60% response. Results indicated that such medical problems are seen and would be reduced by incorporation of radiopaque materials. However, current technology cannot produce clinically acceptable levels of radiopacity without degrading physical and esthetic properties of the acrylic resin. C1 AREA DENT LAB,FT SAM HOUSTON,TX. RP BLOODWORTH, KE (reprint author), USA,DENT ACTIV,FT ORD,CA 93941, USA. NR 17 TC 11 Z9 11 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD JAN PY 1992 VL 67 IS 1 BP 121 EP 123 DI 10.1016/0022-3913(92)90061-E PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA GZ690 UT WOS:A1992GZ69000026 PM 1548595 ER PT J AU MCCARTNEY, JW AF MCCARTNEY, JW TI THE ABUTMENT CAP - AN ADJUNCT TO JAW RELATIONSHIP RECORD-MAKING WITH OSSEOINTEGRATED IMPLANTS SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article RP MCCARTNEY, JW (reprint author), WALTER REED ARMY MED CTR,AREA DENT LAB,WASHINGTON,DC 20307, USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD JAN PY 1992 VL 67 IS 1 BP 130 EP 132 DI 10.1016/0022-3913(92)90063-G PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA GZ690 UT WOS:A1992GZ69000028 PM 1548597 ER PT J AU LEGGETT, DC MIYARES, PH JENKINS, TF AF LEGGETT, DC MIYARES, PH JENKINS, TF TI APPARENT DONOR-ACCEPTOR INTERACTION BETWEEN NITROAROMATICS AND ACETONITRILE SO JOURNAL OF SOLUTION CHEMISTRY LA English DT Article DE PARTITION COEFFICIENTS; DONOR-ACCEPTOR COMPLEXES; SALTING-OUT; GROUP CONTRIBUTION ID WATER PARTITION-COEFFICIENTS; ORGANIC NONELECTROLYTES; SOLUTES AB The partitioning behavior of nitro-aromatics in octanol-water and acetonitrile/NaCl-saturated water was examined. The nitro group contribution is opposite in the two systems, from which two different bonding mechanisms were inferred. In addition to cavity effects the octanol-water system is characterized by H-bonding of water to the nitro groups, while in the acetonitrile/NaCl-saturated water system electron donor-acceptor complexation predominates. A linear free energy relationship which relates the partition coefficients in the two systems was log P(aw) = 0.727 log P(ow) + 0.395 n + 0.742 where n is the number of nitro groups per ring. RP LEGGETT, DC (reprint author), USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 11 TC 3 Z9 3 U1 0 U2 0 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0095-9782 J9 J SOLUTION CHEM JI J. Solut. Chem. PD JAN PY 1992 VL 21 IS 1 BP 105 EP 108 DI 10.1007/BF00648983 PG 4 WC Chemistry, Physical SC Chemistry GA HB049 UT WOS:A1992HB04900008 ER PT J AU WAYMACK, JP FERNANDES, G VENKATRAMAN, J FLESCHER, E YURT, RW GUZMAN, RF MASON, AD PRUITT, BA AF WAYMACK, JP FERNANDES, G VENKATRAMAN, J FLESCHER, E YURT, RW GUZMAN, RF MASON, AD PRUITT, BA TI THE EFFECT OF ELEVATED LEVELS OF THROMBOXANE ON HOST RESPONSE TO TUMOR SO JOURNAL OF SURGICAL ONCOLOGY LA English DT Article DE PULMONARY METASTASES MODEL; MACROPHAGE CYTOTOXICITY; LYMPHOCYTES; CYTOTOXICITY; T-SUBSET NUMBERS; BLASTOGENIC RESPONSE; GLUCOSE METABOLISM; ADENOSINE DEAMINASE ID LYMPHOCYTE-PROLIFERATION; ADENOSINE-DEAMINASE; ANIMAL-MODEL; PROSTACYCLIN; CANCER; PROSTAGLANDINS; LEUKOTRIENES; PLASMA; TISSUE; SHOCK AB Previous studies have demonstrated that human malignancies can synthesize large amounts of thromboxane. It has also been reported that thromboxane can significantly alter multiple components of physiologic and immunologic function. We investigated the effect of elevated levels of thromboxane on host response to tumor using multiple rat models, and the long acting thromboxane analogue U-46619. Administration of the thromboxane analogue was not found to significantly alter the growth of primary tumors or peritoneal metastases. The analogue was found to significantly decrease mean survival time with a pulmonary metastases model. The thromboxane analogue failed to alter macrophage cytotoxicity, lymphocyte cytotoxicity, T lymphocyte subset numbers, or lymphocyte blastogenic response. Administration of the thromboxane analogue decreased the rate of lymphocyte metabolism of glucose and decreased lymphocyte intracellular adenosine deaminase activity. In conclusion, elevated thromboxane levels do not appear to alter primary tumor growth or host immune function, but do decrease resistance to pulmonary metastases. C1 UNIV TEXAS,HLTH SCI CTR,DEPT IMMUNOL,SAN ANTONIO,TX 78284. CORNELL UNIV,MED CTR,NEW YORK HOSP,NEW YORK,NY 10021. RP WAYMACK, JP (reprint author), USA,INST SURG RES,LIB BRANCH,FT SAM HOUSTON,SAN ANTONIO,TX 78234, USA. NR 20 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0022-4790 J9 J SURG ONCOL JI J. Surg. Oncol. PD JAN PY 1992 VL 49 IS 1 BP 3 EP 9 DI 10.1002/jso.2930490103 PG 7 WC Oncology; Surgery SC Oncology; Surgery GA HA652 UT WOS:A1992HA65200002 PM 1548878 ER PT J AU RASPET, R YAO, LX FRANKE, SJ WHITE, MJ AF RASPET, R YAO, LX FRANKE, SJ WHITE, MJ TI THE INFLUENCE OF WIND AND TEMPERATURE-GRADIENTS ON SOUND-PROPAGATION, CALCULATED WITH THE 2 WAY WAVE-EQUATIONS - COMMENTS SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Letter AB In a recent paper Nijs and Wapenaar [J. Acoust. Am. 87, 1987-1998 (1990)] have developed a method for solving for the effects of horizontal winds on sound propagation in the atmosphere. In this development, Nijs and Wapenaar neglect terms containing the density gradient of the atmosphere which in their notation are comparable to the effects of the adiabatic temperature lapse rate on the sound-speed gradient. Their method represents a significant improvement over the use of an effective sound-speed gradient to express the effects of the wind only for high propagation angles. For these situations, one would expect errors due to the change in ambient pressure and density to be greatest. In this letter, a numerically attractive method to incorporate horizontal winds and a hydrostatic density gradient into a two-dimensional transform solution for sound propagation in the atmosphere is developed. In addition, Nijs and Wapenaar approximate the two-dimensional Fourier transforms by a single one-dimensional transform with little justification. Conditions are discussed under which such an approximation may be valid and it is demonstrated that these conditions are unlikely to be met by the two-dimensional kernal of Nijs and Wapenaar. C1 UNIV ILLINOIS,DEPT ELECT & COMP ENGN,URBANA,IL 61801. USA,CONSTRUCT ENGN RES LABS,CHAMPAIGN,IL 61824. RP RASPET, R (reprint author), UNIV MISSISSIPPI,PHYS ACOUST RES GRP,UNIVERSITY,MS 38677, USA. RI White, Michael/B-3612-2009 OI White, Michael/0000-0001-8450-9135 NR 3 TC 5 Z9 5 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD JAN PY 1992 VL 91 IS 1 BP 498 EP 500 DI 10.1121/1.402736 PG 3 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA HE385 UT WOS:A1992HE38500046 ER PT J AU CALOMINO, AM BREWER, DN AF CALOMINO, AM BREWER, DN TI CONTROLLED CRACK-GROWTH SPECIMEN FOR BRITTLE SYSTEMS SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Article DE CRACK GROWTH; FRACTURE; BRITTLE MATERIALS; TOUGHNESS; TESTING ID FRACTURE-TOUGHNESS AB A pure Mode I fracture specimen and test procedure has been developed which provides extended, stable, through-thickness crack growth in ceramics and other brittle, nonmetallic materials. Fixed displacement loading, applied at the crack mouth, promotes stable crack extension by reducing the stored elastic strain energy. Extremely fine control of applied displacements is achieved by utilizing the Poisson expansion of a compressively loaded cylindrical pin. Stable cracks have been successfully grown in soda-lime glass and monolithic Al2O3 for lengths in excess of 20 mm without uncontrollable catastrophic failure. RP CALOMINO, AM (reprint author), NASA,LEWIS RES CTR,USA,AVIAT RES & TECHNOL ACTIV,PROPULS DIRECTORATE,CLEVELAND,OH 44135, USA. NR 7 TC 7 Z9 7 U1 0 U2 1 PU AMER CERAMIC SOC PI WESTERVILLE PA 735 CERAMIC PLACE, PO BOX 6136, WESTERVILLE, OH 43081-6136 SN 0002-7820 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD JAN PY 1992 VL 75 IS 1 BP 206 EP 208 DI 10.1111/j.1151-2916.1992.tb05467.x PG 3 WC Materials Science, Ceramics SC Materials Science GA HF198 UT WOS:A1992HF19800036 ER PT J AU DUQUE, EPN AF DUQUE, EPN TI A NUMERICAL-ANALYSIS OF THE BRITISH EXPERIMENTAL ROTOR PROGRAM BLADE SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB Two computational fluid dynamic codes which respectively solve the compressible full-potential and the Reynolds-Averaged, Thin-Layer, Navier-Stokes equations were used to analyze the nonrotating aerodynamic characteristics of the British Experimental Rotor Program (BERP) helicopter blade. Three flow regimes were investigated: low angle of attack, high angle of attack, and transonic speeds. At low angle of attack, the BERP blade exhibited higher induced drag at a given lift as compared to other blade shapes such as rectangular, Puma, and a swept-tapered planform. But, it had less induced drag than a 3:1 taper tip blade planform. Also, the computed pressure distribution and spanwise loading at low angles of attack indicated a high leading-edge suction peak at the blade notch and a drop in local life coefficient at the swept section of the blade. At high angles of attack, the blade attained high-lift by maintaining attached flow at the outermost spanwise locations. In the transonic regime, the BERP reduced wave drag and shock-induced separation by reducing the shock strength at the outer spanwise locations. Overall, the computations indicate that the blade planform has the largest effects on both the separation and transonic behavior of the blade and that the BERP blade has many favorable aerodynamic characteristics in comparison to conventional helicopter rotor blades. RP DUQUE, EPN (reprint author), USA,AEROFLIGHTDYNAM DIRECTORATE,AVSCOM,MOFFETT FIELD,CA, USA. NR 12 TC 6 Z9 6 U1 0 U2 0 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD JAN PY 1992 VL 37 IS 1 BP 46 EP 54 PG 9 WC Engineering, Aerospace SC Engineering GA HD472 UT WOS:A1992HD47200004 ER PT J AU DUBEY, JP HAMIR, AN BROWN, C RUPPRECHT, CE AF DUBEY, JP HAMIR, AN BROWN, C RUPPRECHT, CE TI SARCOCYSTIS-SEHI SP-N (PROTOZOA, SARCOCYSTIDAE) FROM THE PORCUPINE (ERETHIZON-DORSATUM) SO JOURNAL OF THE HELMINTHOLOGICAL SOCIETY OF WASHINGTON LA English DT Note DE PROTOZOA; APICOMPLEXA; COCCIDIA; SARCOCYSTIS-SEHI; SARCOCYSTS; PORCUPINE; ERETHIZON-DORSATUM AB Sarcocysts were found in muscles of tongue, heart, esophagus, diaphragm, and masseter in 10 porcupines (Erethizon dorsatum) from Sullivan County, Pennsylvania. The sarcocysts were up to 2.3 mm long and 135-mu-m wide. The sarcocyst wall was 0.3-1.2-mu-m thick, including the projections on the wall. The parasitophorous vacuole membrane of the sarcocyst wall had conical protuberances at irregular distances and short (60 nm) electron-dense blebs. The bradyzoites were approximately 7 x 1.5-mu-m and the micronemes were restricted to the anterior half a the bradyzoites. Only 1 morphologic type of sarcocyst was found in all porcupines and it is named Sarcocystis sehi. C1 UNIV PENN,SCH VET MED,DEPT PATHOBIOL,KENNETT SQ,PA 19348. USA,MED INST INFECT DIS,FT DETRICK,MD 21702. WISTAR INST,PHILADELPHIA,PA 19104. RP DUBEY, JP (reprint author), USDA ARS,BELTSVILLE AGR RES CTR,INST LIVESTOCK & POULTRY SCI,ZOONOT DIS LAB,BELTSVILLE,MD 20705, USA. NR 3 TC 3 Z9 3 U1 0 U2 0 PU HELMINTHOLOGICAL SOC WASHINGTON PI LAWRENCE PA C/O ALLEN PRESS INC, 1041 NEW HAMPSHIRE ST, LAWRENCE, KS 66044 SN 1049-233X J9 J HELMINTHOL SOC W JI J. Helminthol. Soc. Wash. PD JAN PY 1992 VL 59 IS 1 BP 127 EP 129 PG 3 WC Parasitology; Zoology SC Parasitology; Zoology GA JF679 UT WOS:A1992JF67900016 ER PT J AU SMITH, WJ SANDERS, KM CAULFIELD, JE GROSS, CL AF SMITH, WJ SANDERS, KM CAULFIELD, JE GROSS, CL TI SULFUR MUSTARD-INDUCED BIOCHEMICAL-ALTERATIONS IN PROLIFERATING HUMAN-CELLS IN CULTURE SO JOURNAL OF TOXICOLOGY-CUTANEOUS AND OCULAR TOXICOLOGY LA English DT Article ID NIACINAMIDE; TOXICITY; INVITRO; AGENTS AB Human epidermal keratinocytes (HEK), human epithelial tumor cells (HeLa), and actively proliferating human peripheral blood lymphocytes (PBL) were used as in vitro model systems to investigate the biochemical sequelae of sulfur mustard-induced injury. Sulfur mustard exposure of all three proliferating cell types resulted in inhibition of cell cycle progression in the early S phase. Cytotoxicity due to sulfur mustard was higher in proliferating, mitogen-stimulated PBL than in resting PBL. Niacinamide, an inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase, partially prevented the loss of cellular NAD+ in sulfur mustard-treated cells. Niacinamide also protected against the cytotoxic effects of sulfur mustard for 24 hr. However, this protection waned when cell growth was allowed to proceed up to 72 hr. RP SMITH, WJ (reprint author), USA,MED RES INST CHEM DEF,BIOCHEM PHARMACOL BRANCH,SGRD UV PB,APG EA,ABERDEEN PROVING GROUND,MD 21010, USA. NR 18 TC 12 Z9 12 U1 0 U2 0 PU MARCEL DEKKER INC PI NEW YORK PA 270 MADISON AVE, NEW YORK, NY 10016 SN 0731-3829 J9 J TOXICOL-CUTAN OCUL JI J. Toxicol.-Cutan. Ocul. Toxicol. PY 1992 VL 11 IS 4 BP 293 EP 304 PG 12 WC Ophthalmology; Toxicology SC Ophthalmology; Toxicology GA JR560 UT WOS:A1992JR56000004 ER PT J AU HEDLUND, KW AF HEDLUND, KW TI ANTHRAX TOXIN - HISTORY AND RECENT ADVANCES AND PERSPECTIVES SO JOURNAL OF TOXICOLOGY-TOXIN REVIEWS LA English DT Review ID DEPENDENT ADENYLATE-CYCLASE; PROTECTIVE ANTIGEN GENE; LETHAL FACTOR GENE; BACILLUS-ANTHRACIS; NUCLEOTIDE-SEQUENCE; EUKARYOTIC CELLS; ESCHERICHIA-COLI; CAPSULE PLASMID; EDEMA FACTOR; EXPRESSION AB Since 1980, following the Sverdlovsk incident, there has been an enormous resurgence in research activity on both the nature of Bacillus anthracis and the tripartite toxin it elaborates. A plasmid, pXO1, has been shown to control the production of the toxin components; protective antigen, edema factor and lethal factor. Another plasmid, pXO2, encodes for the protective capsule that inhibits phagocytosis. The mechanism of action of edema factor has been identified as that of an adenylate cyclase. Along with major advances in molecular biology a number of very promising recombinant constructs have been made that shed new light of the roe of individual components. The new attenuated recombinants, engineered so that they can not revert to a fully virulent form, may serve as new live vaccine candidates . RP HEDLUND, KW (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 109 TC 2 Z9 2 U1 0 U2 1 PU MARCEL DEKKER INC PI NEW YORK PA 270 MADISON AVE, NEW YORK, NY 10016 SN 0731-3837 J9 J TOXICOL-TOXIN REV JI J. Toxicol.-Toxin Rev. PY 1992 VL 11 IS 1 BP 41 EP 88 PG 48 WC Toxicology SC Toxicology GA HU529 UT WOS:A1992HU52900002 ER PT J AU MOUL, JW AF MOUL, JW TI RETROPERITONEAL FIBROSIS FOLLOWING RADIOTHERAPY FOR STAGE-I TESTICULAR SEMINOMA SO JOURNAL OF UROLOGY LA English DT Article DE RETROPERITONEAL FIBROSIS; NEOPLASMS, RADIATION-INDUCED; TESTICULAR NEOPLASMS ID HODGKINS-DISEASE; COMPLICATIONS; CANCER AB Retroperitoneal fibrosis, proved by surgical exploration and pathology, was discovered in a patient 13 years after 3,000 rad external beam cobalt retroperitoneal radiation therapy for stage I testicular seminoma. Ureteral obstruction resulted in the loss of 1 kidney, necessitating ipsilateral nephrectomy and contralateral ureterolysis. To my knowledge this is the first reported case of retroperitoneal fibrosis occurring after radiotherapy for testicular cancer. C1 WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307. RP MOUL, JW (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,ROOM A3019,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. NR 17 TC 16 Z9 17 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD JAN PY 1992 VL 147 IS 1 BP 124 EP 126 PG 3 WC Urology & Nephrology SC Urology & Nephrology GA GX782 UT WOS:A1992GX78200032 PM 1729501 ER PT J AU NICELY, ER COSTABILE, RA MOUL, JW AF NICELY, ER COSTABILE, RA MOUL, JW TI RUPTURE OF THE DEEP DORSAL VEIN OF THE PENIS DURING SEXUAL INTERCOURSE SO JOURNAL OF UROLOGY LA English DT Article DE PENIS; PENILE ERECTION; ARTERIES; RUPTURE ID FRACTURE; CAVERNOSOGRAPHY; MANAGEMENT AB The sudden onset of pain, swelling and ecchymosis of the penis during sexual intercourse is the typical presentation of traumatic rupture of the corpus cavernosum, commonly termed fracture of the penis. We report a case of isolated traumatic rupture of the deep dorsal vein of the penis. The condition has essentially the same presentation as corpus cavernosal rupture, and should be considered in the evaluation and treatment of the acute penis. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,4301 JONES BRIDGE RD,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307. NR 8 TC 36 Z9 37 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD JAN PY 1992 VL 147 IS 1 BP 150 EP 152 PG 3 WC Urology & Nephrology SC Urology & Nephrology GA GX782 UT WOS:A1992GX78200043 PM 1729512 ER PT J AU MICHAEL, NL VAHEY, M BURKE, DS REDFIELD, RR AF MICHAEL, NL VAHEY, M BURKE, DS REDFIELD, RR TI VIRAL-DNA AND MESSENGER-RNA EXPRESSION CORRELATE WITH THE STAGE OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) TYPE-1 INFECTION IN HUMANS - EVIDENCE FOR VIRAL REPLICATION IN ALL STAGES OF HIV DISEASE SO JOURNAL OF VIROLOGY LA English DT Article ID BLOOD; LYMPHOCYTES; CELLS AB Studies of cultivatable human immunodeficiency virus type 1 (HIV-1) from plasma samples from infected patients have shown a correspondence between increasing viral burden and disease progression, but these measurements are selective and thus nonrepresentative of the in vivo viral load. Quantitation of proviral DNA sequences by the polymerase chain reaction in purified CD4+ T cells has shown a similar relationship but does not provide a measure of viral gene expression. We have studied viral DNA, genomic RNA, and spliced mRNA expression of HIV-1 in infected patients with a quantitative polymerase chain reaction assay. Viral RNA expression is detected in all stages of infection. These data show that the natural history of HIV infection is associated with a shift in the balance of viral expression favoring the production of genomic RNA without a preceding period of true viral latency. RP MICHAEL, NL (reprint author), WALTER REED ARMY MED CTR,DEPT RETROVIRAL RES,DIV RETROVIROL,13 TAFT COURT,SUITE 200,ROCKVILLE,MD 20850, USA. NR 18 TC 178 Z9 178 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD JAN PY 1992 VL 66 IS 1 BP 310 EP 316 PG 7 WC Virology SC Virology GA GU971 UT WOS:A1992GU97100038 PM 1727491 ER PT J AU ELGAR, S GUZA, RT FREILICH, MH BRIGGS, MJ AF ELGAR, S GUZA, RT FREILICH, MH BRIGGS, MJ TI LABORATORY SIMULATIONS OF DIRECTIONALLY SPREAD SHOALING WAVES SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article ID SURFACE GRAVITY-WAVES; NONLINEAR REFRACTION DIFFRACTION; SHALLOW-WATER; MODEL; BISPECTRA; BEACH AB Field observations of a shoaling, nonbreaking, directionally spread wave field are simulated in a laboratory basin to determine whether laboratory artifacts cause significant distortions of the shoaling process. The laboratory wave field is measured with scaled arrays of surface-elevation sensors similar to the arrays used for the field observations. However, differences in the laboratory and field beach slopes (0.033 and 0.025, respectively) do not allow precise replication of the field conditions in the laboratory. Therefore, a nonlinear wave propagation model with no adjustable parameters (previously successfully compared to a wide range of field data) is used to show that differences between the laboratory and field data sets are caused primarily by the different beach slopes. The observations demonstrate, in agreement with the model, that it is possible to compensate partially for differences in beach slope by altering the initial conditions. With such compensation, the evolution of surface-elevation power spectra, bispectra, and skewness and asymmetry are remarkably similar in the laboratory and field. Frequency-directional spectra measured just outside the surf zone also show similar nonlinear effects in both field and laboratory data. Based on this case study, the laboratory directional wave basin appears to be useful for investigating the linear and nonlinear evolution of random, two-dimensional waves on beaches. C1 UNIV CALIF SAN DIEGO,SCRIPPS INST OCEANOG,CTR COASTAL STUDIES,LA JOLLA,CA 92093. CALTECH,JET PROP LAB,PASADENA,CA 91109. WATERWAYS EXPT STN,COASTAL ENGN RES CTR,VICKSBURG,MS 39180. RP ELGAR, S (reprint author), WASHINGTON STATE UNIV,ELECT & COMP ENGN,PULLMAN,WA 99164, USA. NR 19 TC 5 Z9 5 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD JAN-FEB PY 1992 VL 118 IS 1 BP 87 EP 103 DI 10.1061/(ASCE)0733-950X(1992)118:1(87) PG 17 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA GW546 UT WOS:A1992GW54600007 ER PT J AU LUNDSTROM, JO TURELL, MJ NIKLASSON, B AF LUNDSTROM, JO TURELL, MJ NIKLASSON, B TI ANTIBODIES TO OCKELBO VIRUS IN 3 ORDERS OF BIRDS (ANSERIFORMES, GALLIFORMES AND PASSERIFORMES) IN SWEDEN SO JOURNAL OF WILDLIFE DISEASES LA English DT Note DE ALPHAVIRUS; OCKELBO VIRUS; ANTIBODIES; BIRDS; SEROSURVEY; AMPLIFICATION HOSTS ID DISEASE AB Sera from 324 birds collected in an Ockelbo virus disease endemic area in central Sweden were examined for the presence of specific antibodies to Ockelbo virus by a plaque reduction neutralization test. Birds examined belonged to the orders Anseriformes (n = 207), Galliformes (n = 66) and Passeriformes (n = 51). Ockelbo virus neutralizing antibodies were detected in 26 (8%) of the specimens, including species from each of the three orders tested. Specific antibodies found in caged birds and in 6- to 10-week-old birds suggested local transmission. The highest antibody prevalence (27%, 14/51) was observed in the Passeriformes in which 5 of 9 species tested contained antibodies. The high antibody prevalence in passeriforms and the verv large population of this group in relation to other avian groups in Sweden gives them a high potential as amplification hosts for Ockelbo virus. C1 NATL BACTERIOL LAB,KAROLINSKA INST,DEPT VIROL,S-10521 STOCKHOLM,SWEDEN. USA,MED RES INST INFECT DIS,DIV VIROL,DEPT ARBOVIRAL ENTOMOL,FREDERICK,MD 21702. SWEDISH DEF RES ESTAB,S-17290 SUNDBYBERG,SWEDEN. NR 16 TC 17 Z9 18 U1 0 U2 1 PU WILDLIFE DISEASE ASSN, INC PI LAWRENCE PA 810 EAST 10TH ST, LAWRENCE, KS 66044-8897 SN 0090-3558 J9 J WILDLIFE DIS JI J. Wildl. Dis. PD JAN PY 1992 VL 28 IS 1 BP 144 EP 147 PG 4 WC Veterinary Sciences SC Veterinary Sciences GA HB253 UT WOS:A1992HB25300025 PM 1312646 ER PT J AU MERSMANN, TJ BUEHLER, DA FRASER, JD SEEGAR, JKD AF MERSMANN, TJ BUEHLER, DA FRASER, JD SEEGAR, JKD TI ASSESSING BIAS IN STUDIES OF BALD EAGLE FOOD-HABITS SO JOURNAL OF WILDLIFE MANAGEMENT LA English DT Article ID REMAINS AB Although studies of bald eagle (Haliaeetus leucocephalus) food habits are numerous, few authors have quantified biases inherent in the techniques used. In our study of food habits of nonbreeding bald eagles on the northern Chesapeake Bay, we examined biases associated with pellet analysis, food remains analysis, and direct observation. We assessed these biases through controlled feedings of 2 captive bald eagles and through observations of free-ranging eagles. Fish fed to 2 captive bald eagles were underrepresented (P < 0.001) in egested pellets. Most bird and mammal food items were detected in greater-than-or-equal-to 1 pellet; however, species and carcass condition affected frequency of occurrence. Analysis of captive eagles' food remains overrepresented birds, medium-sized mammals, and large bony fish (P < 0.001); small mammals and small fish were underrepresented (P < 0.001). This bias increased over time due to greater persistence of some remains in shoreline plots. Direct observations of free-ranging eagles resulted in biases toward easily identified species such as eels and catfish, but also documented the use of small, soft-bodied fish, which were not well documented by the other techniques. Because of the variety of biases present, accurate assessment of bald eagle foods requires use of multiple techniques. C1 VIRGINIA POLYTECH INST & STATE UNIV,DEPT FISHERIES & WILDLIFE SCI,BLACKSBURG,VA 24061. USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. NR 24 TC 65 Z9 66 U1 0 U2 11 PU WILDLIFE SOC PI BETHESDA PA 5410 GROSVENOR LANE, BETHESDA, MD 20814-2197 SN 0022-541X J9 J WILDLIFE MANAGE JI J. Wildl. Manage. PD JAN PY 1992 VL 56 IS 1 BP 73 EP 78 DI 10.2307/3808792 PG 6 WC Ecology; Zoology SC Environmental Sciences & Ecology; Zoology GA HA129 UT WOS:A1992HA12900008 ER PT J AU BRANTON, PA TAVASSOLI, FA AF BRANTON, PA TAVASSOLI, FA TI MIXED TUMORS OF THE VAGINA - A CLINICOPATHOLOGICAL, IMMUNOHISTOCHEMICAL, AND ULTRASTRUCTURAL ANALYSIS OF 28 CASES SO LABORATORY INVESTIGATION LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,WASHINGTON,DC 20306. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0023-6837 J9 LAB INVEST JI Lab. Invest. PD JAN PY 1992 VL 66 IS 1 BP A62 EP A62 PG 1 WC Medicine, Research & Experimental; Pathology SC Research & Experimental Medicine; Pathology GA HA276 UT WOS:A1992HA27600372 ER PT J AU WOOD, RL SLINEY, DH BASYE, RA AF WOOD, RL SLINEY, DH BASYE, RA TI LASER REFLECTIONS FROM SURGICAL-INSTRUMENTS SO LASERS IN SURGERY AND MEDICINE LA English DT Article DE HAZARDS; SAFETY; REFLECTIONS AB The potential hazards to the eye and skin from accidental exposures caused by reflected laser beams from surgical instruments has long been of concern to operating room staff members. Reflectance values for argon neodymium:YAG and CO2 laser wave-lengths were measured from 29 reference surfaces used on surgical instruments. From these measurements, nominal hazard zones could be determined for typical reflection hazards. C1 USA,ENVIRONM HYG AGCY,DIV LASER MICROWAVE,ABERDEEN PROVING GROUND,MD 21010. SIMPSON BASYE INC,WILMINGTON,DE 19804. NR 6 TC 9 Z9 10 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0196-8092 J9 LASER SURG MED JI Lasers Surg. Med. PY 1992 VL 12 IS 6 BP 675 EP 678 DI 10.1002/lsm.1900120618 PG 4 WC Dermatology; Surgery SC Dermatology; Surgery GA KA047 UT WOS:A1992KA04700017 PM 1453871 ER PT J AU HEBDEN, RA CLAYBAUGH, JR HASHIRO, GM AF HEBDEN, RA CLAYBAUGH, JR HASHIRO, GM TI COMPARATIVE EFFECTS OF DES LEU ANGIOTENSIN-I AND ANGIOTENSIN-II ON AVP SECRETION FROM THE HYPOTHALAMONEUROHYPOPHYSIS AND PITUITARY OF THE RAT SO LIFE SCIENCES LA English DT Article ID HYPOTHALAMO-NEUROHYPOPHYSEAL SYSTEM; VASOPRESSIN RELEASE; OSMOTIC CONTROL; ORGAN-CULTURE; IMMUNOREACTIVE CELLS; EXPLANTS; INVITRO; FIBERS; BRAIN AB In the present study we compared the effects of Des Leu Angiotensin I (Des Leu AI) with Angiotensin II (AII) on the secretion of vasopressin (AVP) from the isolated hypothalamoneurohypophyseal system (HNS) and isolated posterior pituitary gland of the rat. Administration of 10(-6)M, 10(-5)M and 10(-4)M Des Leu AI was without significant effect on AVP secretion from the HNS. A similar phenomenon was seen in the posterior pituitary with 10(-6)M and 10(-5)M Des Leu AI, although 10(-4)M significantly increased AVP release. Administration of 10(-6)M AII was without significant effect in either preparation, although 10(-5)M and 10(-4)M AII caused significant dose-dependent increases in AVP secretion over control release that were similar in both the HNS and posterior pituitary gland. These results suggest that Des Leu AI is not a physiologically relevant stimulus of AVP secretion when restricted to this area of the rat brain. They are also consistent with the presence of receptors sensitive to AII in the pituitary gland of the rat. C1 TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96859. NR 29 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0024-3205 J9 LIFE SCI JI Life Sci. PY 1992 VL 51 IS 3 BP 195 EP 202 DI 10.1016/0024-3205(92)90075-Z PG 8 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA HY845 UT WOS:A1992HY84500004 PM 1614285 ER PT J AU MATTHEW, CB FRANCESCONI, RP HUBBARD, RW AF MATTHEW, CB FRANCESCONI, RP HUBBARD, RW TI PHYSOSTIGMINE - DOSE-RESPONSE EFFECTS ON ENDURANCE AND THERMOREGULATION DURING EXERCISE SO LIFE SCIENCES LA English DT Article ID PRETREATMENT DRUG; RATS; PERFORMANCE; PROTECTION; SOMAN; HEAT AB We previously reported that the administration of 200 ug/kg of physostigmine (PH) to rats exercising on a treadmill resulted in decrements in both endurance (decreased running time to exhaustion) and thermoregulation. However, it was necessary to determine the dose-response effects of PH administration before PH-treated exercising rats could be used as a model with which to examine the relative anticholinergic potency of drugs. In the present work saline, 50, 100, or 200 ug/kg of physostigmine salicylate (0%, 40%, 50%, and 60% whole blood cholinesterase inhibition) was administered to rats (N = 12/group) prior to treadmill exercise (26-degrees-C, 50% rh, 11 m/min, 6-degrees incline) . The saline control group ran for 67 +/- 6 min (mean +/- SE) with a rate of rise of core temperature of 0. 51 +/-0.007-degrees-C /min. The run times declined (80%, 64% and 48% of control) as rate of rise of core temperature increased (116%, 180%, and 214% of control) in a dose-dependent manner (50, 100, 200 ug/kg PH) . Cholinergic symptoms such as salivation, tremors, and defecation were also affected in a dose-dependent manner by PH administration. Since cholinergic symptoms, thermoregulatory effects, and endurance decrements all vary in a dose-dependent manner with physostigmine administration, the exercising rat represents a useful model for examining the relative potency of cholinergic therapies. RP MATTHEW, CB (reprint author), USA,ENVIRONM MED RES INST,NATICK,MA 01760, USA. NR 19 TC 4 Z9 4 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0024-3205 J9 LIFE SCI JI Life Sci. PY 1992 VL 50 IS 1 BP 39 EP 44 DI 10.1016/0024-3205(92)90195-U PG 6 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA GT537 UT WOS:A1992GT53700006 PM 1728723 ER PT J AU PERRY, JJ JELINEK, JS AF PERRY, JJ JELINEK, JS TI ISOLATED CENTRAL-NERVOUS-SYSTEM RELAPSE OF TESTICULAR CANCER SO MEDICAL AND PEDIATRIC ONCOLOGY LA English DT Article DE TESTICULAR NEOPLASMS; BRAIN; RADIOTHERAPY ID GERM-CELL TUMORS; BRAIN METASTASES; MANAGEMENT AB Central nervous system involvement with testicular cancer usually occurs with advanced systemic disease. Isolated CNS disease at relapse is rare. We report a patient who developed a solitary brain metastasis with no other systemic disease after having achieved a complete response to frontline therapy. After combined modality therapy for the CNS disease, the patient has remained disease-free for more than 3 years. The literature regarding brain metastases in relapsed testicular cancer is reviewed, including nine cases of isolated brain metastases. The CNS can be a "sanctuary" site for testicular cancer, and in the unusual subset of patients with isolated brain relapse, long-term remission is possible with aggressive therapy. C1 WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT NUCL MED,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT RADIOL,BETHESDA,MD 20814. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. RP PERRY, JJ (reprint author), WALTER REED ARMY MED CTR,DEPT MED,HEMATOL ONCOL SERV,WASHINGTON,DC 20307, USA. NR 6 TC 8 Z9 8 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0098-1532 J9 MED PEDIATR ONCOL JI Med. Pediatr. Oncol. PY 1992 VL 20 IS 1 BP 68 EP 70 DI 10.1002/mpo.2950200115 PG 3 WC Oncology; Pediatrics SC Oncology; Pediatrics GA GV593 UT WOS:A1992GV59300014 PM 1370071 ER PT J AU MUN, SK GOERINGER, LTCF AF MUN, SK GOERINGER, LTCF TI AN IMAGE MANAGEMENT AND COMMUNICATIONS (IMAC) SYSTEM FOR RADIOLOGY SO MEDICAL PROGRESS THROUGH TECHNOLOGY LA English DT Article DE DIGITAL IMAGING; NETWORK; COMMUNICATION AB Managing x-ray films is a difficult problem in a hospital. Advances in digital imaging, high speed networks and high fidelity displays make it possible to develop an image management and communication system for a hospital. As many of the technical problems are solved, many operational problems remain. Experience with a prototype installation became the basis for a much more comprehensive implementation of a fully digital filmless imaging support system in a number of hospitals. The use of IMAC technology will bring about profound changes in the radiology community; physicians, administrators, manufactures of imaging systems and the users of radiology service, the patients. C1 USA,MED MAT AGCY,MDIS PROJECT OFF,FREDERICK,MD 21702. RP MUN, SK (reprint author), GEORGETOWN UNIV,MED CTR,DEPT RADIOL,WASHINGTON,DC 20007, USA. NR 15 TC 2 Z9 2 U1 0 U2 0 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0047-6552 J9 MED PROG TECHNOL JI Med. Prog. Technol. PY 1992 VL 18 IS 3 BP 165 EP 179 PG 15 WC Engineering, Biomedical SC Engineering GA KF337 UT WOS:A1992KF33700004 PM 1484513 ER PT J AU KLEIN, TA LIMA, JBP TANG, AT AF KLEIN, TA LIMA, JBP TANG, AT TI SEASONAL DISTRIBUTION AND DIEL BITING PATTERNS OF CULICINE MOSQUITOS IN COSTA MARQUES, RONDONIA, BRAZIL SO MEMORIAS DO INSTITUTO OSWALDO CRUZ LA English DT Article DE CULEX; MANSONIA; PSORPHORA; AEDES; AEDEOMYIA; COQUILLETTIDIA; MOSQUITO; BEHAVIOR ID EQUINE ENCEPHALITIS; VIRUS; ARBOVIRUS AB A study of peridomestic man-biting culicines in the Amazon Basin was conducted from January through December, 1987. Fifteen species of mosquitoes from six genera were collected by volunteers in all-night human-bait indoor and outdoor collections at five houses in and near the town of Costa Marques, Rondonia, Brazil. Culex quinquefasciatus and members of the Mansonia titillans/indubitans Group comprised 61 and 33%, respectively, of all culicines collected from human-bait outside houses and 62 and 35%, respectively, of those collected from volunteers inside houses in the town. In rural areas, Cx. quinquefasciatus was less abundant and only comprised 2 and 5% of the culicines, respectively, collected inside and outside houses. Mansonia titillans/indubitans Group comprised 75% and 86% of the culicines collected inside and outside houses, respectively from rural residences. Culex quinquefasciatus and members of the Mn. titillans/indubitans Group were more endophilic than other culicines collected. Nocturnal and seasonal biting rhythms for the more common culicines are described. C1 USA,MED RES UNIT,BRAZIL AMER CONSULATE RIO,APO,MIAMI,FL 34030. RP KLEIN, TA (reprint author), UNIV BRASILIA,BR-70910 BRASILIA,DF,BRAZIL. NR 16 TC 10 Z9 11 U1 0 U2 1 PU MEM INST OSWALDO CRUZ PI RIO DE JANEIRO PA SECRETARY CAIXA POSTAL 926, 20001 RIO DE JANEIRO, RJ, BRAZIL SN 0074-0276 J9 MEM I OSWALDO CRUZ JI Mem. Inst. Oswaldo Cruz PD JAN-MAR PY 1992 VL 87 IS 1 BP 141 EP 148 PG 8 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA JQ514 UT WOS:A1992JQ51400021 PM 1364053 ER PT J AU DAMIAN, RT DELAROSA, MA MURFIN, DJ RAWLINGS, CA WEINA, PJ XUE, YP AF DAMIAN, RT DELAROSA, MA MURFIN, DJ RAWLINGS, CA WEINA, PJ XUE, YP TI FURTHER DEVELOPMENT OF THE BABOON AS A MODEL FOR ACUTE SCHISTOSOMIASIS SO MEMORIAS DO INSTITUTO OSWALDO CRUZ LA English DT Article; Proceedings Paper CT 3RD INTERNATIONAL SYMP ON SCHISTOSOMIASIS / 3RD NATIONAL MEETING ON SCHISTOSOMIASIS CY OCT 20-25, 1991 CL RECIFE, BRAZIL SP FUNDACAO OSWALDO CRUZ, CTR PESQUISAS AGGEU MAGALHAES DE SCHISTOSOMA-MANSONI; EXPERIMENTAL MODEL; ACUTE STAGE; BABOON ID IRRADIATED CRYOPRESERVED SCHISTOSOMULA; HYPERSENSITIVITY GRANULOMA-FORMATION; CIRCULATING IMMUNE-COMPLEXES; MANSONI EGGS INVITRO; CHALLENGE INFECTION; ACQUISITION AB Baboons develop a syndrome, including eosinophilia and transient fever, after infection with carcariae of Schistosoma mansoni that is consistent with the human syndrome of acute schistosomiasis. Radiotelemetry can be used to follow the course of fever in infected baboons. Individual variations in intensity of disease were noted in baboons. These symptoms and signs were more closely linked to the onset of oviposition by the newly matured worms than they were to the presence of migrating schistosomula or maturing worms. The baboon is concluded to be a suitable and useful model for human acute schistosomiasis mansoni. C1 UNIV GEORGIA,DEPT SMALL ANIM MED,ATHENS,GA 30602. WALTER REED ARMY INST RES,DEPT PARASITOL,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. RP DAMIAN, RT (reprint author), UNIV GEORGIA,DEPT ZOOL,ATHENS,GA 30602, USA. FU NCRR NIH HHS [SO7 RR 07025] NR 33 TC 26 Z9 27 U1 0 U2 0 PU MEM INST OSWALDO CRUZ PI RIO DE JANEIRO PA SECRETARY CAIXA POSTAL 926, 20001 RIO DE JANEIRO, RJ, BRAZIL SN 0074-0276 J9 MEM I OSWALDO CRUZ JI Mem. Inst. Oswaldo Cruz PY 1992 VL 87 SU 4 BP 261 EP 269 PG 9 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA LB150 UT WOS:A1992LB15000042 PM 1343906 ER PT J AU BRUCE, JI MILLER, R LIGHTNER, L YOGANATHAN, S AF BRUCE, JI MILLER, R LIGHTNER, L YOGANATHAN, S TI EFFICACY OF NICLOSAMIDE AS A POTENTIAL TOPICAL ANTIPENETRANT (TAP) AGAINST CERCARIAE OF SCHISTOSOMA-MANSONI IN MONKEYS SO MEMORIAS DO INSTITUTO OSWALDO CRUZ LA English DT Article; Proceedings Paper CT 3RD INTERNATIONAL SYMP ON SCHISTOSOMIASIS / 3RD NATIONAL MEETING ON SCHISTOSOMIASIS CY OCT 20-25, 1991 CL RECIFE, BRAZIL SP FUNDACAO OSWALDO CRUZ, CTR PESQUISAS AGGEU MAGALHAES DE SCHISTOSOMA-MANSONI; CERCARIAE; NICLOSAMIDE; PROTECTION ID MICE; PROPHYLAXIS; INFECTIONS AB A 1% (W/V) formulation of Niclosamide (2, 5-Dichloro-4-nitrosalicylanilide) (TAP) was tested on Cebus apella monkeys as a topical prophylactic against schistosomiasis mansoni. Two experiments were conducted using the same formulation. In the first experiment, the TAP provided complete protection against schistosomiasis for 3 days. Of the 4 monkeys treated with TAP 7 days before exposure to Schistosoma mansoni cercariae, 2 were completely protected. The remaining 2 monkeys of the 7 day treatment group had a 78% or greater reduction in adult worm burdens when compared to the placebo treated monkeys. The second experiment was designed to determine the time between day 3 and 7 when the TAP no longer provided complete protection. However, all of the TAP treated monkeys in this experiment were completely protected, even the monkeys treated 7 days earlier. In both experiments, all monkeys used as infection controls and those receiving only the placebo became infected and showed typical experimental schistosomiasis. These results demonstrate that the TAP could provide fast acting, short-term protection to people who must enter cercariae infested water. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PREVENT MED & BIOMET,BETHESDA,MD 20814. USA,MED MAT DEV ACT,DIV BIOL SYST,FREDERICK,MD 21702. RP BRUCE, JI (reprint author), UNIV LOWELL,CTR TROP DIS,LOWELL,MA 01854, USA. NR 24 TC 2 Z9 2 U1 1 U2 1 PU MEM INST OSWALDO CRUZ PI RIO DE JANEIRO PA SECRETARY CAIXA POSTAL 926, 20001 RIO DE JANEIRO, RJ, BRAZIL SN 0074-0276 J9 MEM I OSWALDO CRUZ JI Mem. Inst. Oswaldo Cruz PY 1992 VL 87 SU 4 BP 281 EP 289 PG 9 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA LB150 UT WOS:A1992LB15000045 PM 1343909 ER PT J AU KLEIN, TA LIMA, JBP TANG, AT AF KLEIN, TA LIMA, JBP TANG, AT TI VECTOR INCRIMINATION AND EFFECTS OF ANTIMALARIAL-DRUGS ON MALARIA TRANSMISSION AND CONTROL IN THE AMAZON BASIN OF BRAZIL SO MEMORIAS DO INSTITUTO OSWALDO CRUZ LA English DT Article; Proceedings Paper CT 4TH INTERNATIONAL CONGRESS ON MALARIA AND BABESIOSIS CY AUG 13-17, 1991 CL RIO DE JANEIRO, BRAZIL SP FDN MARCEL MERIEUX, FUNDACAO NACL SAUDE, CONSELHO NACL DESENVOLVIMENTO CIENT & TECNOL, FINANCIADORA ESTUDOS & PROJETOS, FAO, PAN AMER HLTH ORG, BANCO BRASILEIRO DESCONTOS SA, COODENACAO APERFEICOAMENTO PESSOAL NIVEL SUPER, CARL ZEISS BRASIL, BRIT COUNCIL DE ANOPHELES-DARLINGI; ANOPHELES SP; QUININE; TETRACYCLINE; CHLOROQUINE; MALARIA; CONTROL; PLASMODIUM; BRAZIL ID COMPARATIVE SUSCEPTIBILITY; PLASMODIUM-FALCIPARUM; ANOPHELINE MOSQUITOS; COSTA-MARQUES; RONDONIA; INFECTION; VIVAX AB World ecosystems differ significantly and a multidisciplinary malaria control approach must be adjusted to meet these requirements. These include a comprehensive understanding of the malaria vectors, their behavior, seasonal distribution and abundance, susceptibility to insecticides (physiological and behavioral), methods to reduce the numbers of human gametocyte carriers through effective health care systems and antimalarial drug treatment, urban malaria transmission versus rural or forest malaria transmission, and the impact of vaccine development. Many malaria vectors are members of species complexes and individual relationships to malaria transmission, seasonal distribution, biting behavior, etc. is poorly understood. Additionally, malaria patients are not examined for circulating gametocytes and both falciparum and vivax malaria patients may he highly infective to mosquitoes after treatment with currently used antimalarial drugs. Studies on the physiological and behavioral effects of DDT and other insecticides are inconclusive and need to be evaluated. C1 USA,MED RES UNIT BRAZIL,AMER CONSULATE RIO,MIAMI,FL 34030. MINIST SAUDE,SUCAM,CENT ENTOMOL LAB,DIV MAL,BR-70058 BRASILIA,DF,BRAZIL. RP KLEIN, TA (reprint author), WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307, USA. NR 9 TC 8 Z9 8 U1 0 U2 1 PU MEM INST OSWALDO CRUZ PI RIO DE JANEIRO PA SECRETARY CAIXA POSTAL 926, 20001 RIO DE JANEIRO, RJ, BRAZIL SN 0074-0276 J9 MEM I OSWALDO CRUZ JI Mem. Inst. Oswaldo Cruz PY 1992 VL 87 SU 3 BP 393 EP 397 PG 5 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA LE918 UT WOS:A1992LE91800067 PM 1343719 ER PT J AU AIKAWA, M BROWN, AE SMITH, CD TEGOSHI, T HOWARD, RJ HASLER, TH ITO, Y COLLINS, WE WEBSTER, HK AF AIKAWA, M BROWN, AE SMITH, CD TEGOSHI, T HOWARD, RJ HASLER, TH ITO, Y COLLINS, WE WEBSTER, HK TI PLASMODIUM-COATNEYI-INFECTED RHESUS-MONKEYS - A PRIMATE MODEL FOR HUMAN CEREBRAL MALARIA SO MEMORIAS DO INSTITUTO OSWALDO CRUZ LA English DT Article; Proceedings Paper CT 4TH INTERNATIONAL CONGRESS ON MALARIA AND BABESIOSIS CY AUG 13-17, 1991 CL RIO DE JANEIRO, BRAZIL SP FDN MARCEL MERIEUX, FUNDACAO NACL SAUDE, CONSELHO NACL DESENVOLVIMENTO CIENT & TECNOL, FINANCIADORA ESTUDOS & PROJETOS, FAO, PAN AMER HLTH ORG, BANCO BRASILEIRO DESCONTOS SA, COODENACAO APERFEICOAMENTO PESSOAL NIVEL SUPER, CARL ZEISS BRASIL, BRIT COUNCIL DE PLASMODIUM-COATNEYI; HUMAN CEREBRAL MALARIA; ANIMAL MODEL; PATHOLOGY; RHESUS MONKEYS; BRAIN ID PARASITIZED ERYTHROCYTES; FALCIPARUM-MALARIA; CYTOADHERENCE; RECEPTOR; INVITRO AB Although several animal models for human cerebral malaria have been proposed in the past, none have shown pathological findings that are similar to those seen in humans. In order to develop an animal model for human cerebral malaria, we studied the pathology of brains of Plasmodium coatneyi (primate malaria parasite)-infected rhesus monkeys. Our study demonstrated parasitized erythrocyte (PRBC) sequestration and cytoadherence of knobs on PRBC to endothelial cells in cerebral microvessels of these monkeys. This is similar to the findings seen in human cerebral malaria. Cerebral microvessels with sequestered PRBC were shown by immunohistochemistry to possess CD36, TSP and ICAM-1. These proteins were not evident in cerebral microvessels of uninfected control monkeys. Our study indicates, for the first time, that rhesus monkeys infected with P. coatneyi can be used as a primate model to study human cerebral malaria. C1 ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. DNAX RES INST MOLEC & CELLULAR BIOL INC,PALO ALTO,CA 94304. CTR DIS CONTROL,MALARIA BRANCH,ATLANTA,GA 30333. RP AIKAWA, M (reprint author), CASE WESTERN RESERVE UNIV,INST PATHOL,CLEVELAND,OH 44106, USA. FU NIAID NIH HHS [AI-10645] NR 16 TC 6 Z9 6 U1 0 U2 1 PU MEM INST OSWALDO CRUZ PI RIO DE JANEIRO PA SECRETARY CAIXA POSTAL 926, 20001 RIO DE JANEIRO, RJ, BRAZIL SN 0074-0276 J9 MEM I OSWALDO CRUZ JI Mem. Inst. Oswaldo Cruz PY 1992 VL 87 SU 3 BP 443 EP 447 PG 5 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA LE918 UT WOS:A1992LE91800075 PM 1343725 ER PT B AU MAMMONE, RJ BINDER, M WADE, WL AF MAMMONE, RJ BINDER, M WADE, WL BE Mittal, KL TI A STUDY OF METALLIZED THERMOPLASTIC FILMS FOLLOWING GAS PLASMA TREATMENT SO METALLIZED PLASTICS 3: FUNDAMENTAL AND APPLIED ASPECTS LA English DT Proceedings Paper CT 3RD SYMP ON METALLIZED PLASTICS CY OCT 13-18, 1991 CL PHOENIX, AZ SP ELECTROCHEM SOC DIELECT SCI & TECHNOL DIV RP MAMMONE, RJ (reprint author), USA,ETDL LABCOM,DIV POWER SOURCES,SLCET PR,FT MONMOUTH,NJ 07703, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PLENUM PRESS DIV PLENUM PUBLISHING CORP PI NEW YORK PA NEW YORK BN 0-306-44341-4 PY 1992 BP 197 EP 200 PG 4 WC Electrochemistry; Materials Science, Multidisciplinary SC Electrochemistry; Materials Science GA BX36W UT WOS:A1992BX36W00016 ER PT S AU DALRYMPLE, JM AF DALRYMPLE, JM BE Zilinskas, RA TI DOD-SPONSORED VIRUS-VACCINE DEVELOPMENT - AN INVESTIGATORS PERSPECTIVE SO MICROBIOLOGIST AND BIOLOGICAL DEFENSE RESEARCH: ETHICS, POLITICS, AND INTERNATIONAL SECURITY SE ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Proceedings Paper CT CONF ON MICROBIOLOGIST AND BIOLOGICAL DEFENSE RESEARCH : ETHICS, POLITICS, AND INTERNATIONAL SECURITY CY APR 04-05, 1991 CL CATONSVILLE, MD SP MARYLAND BIOTECH INST, CTR PUBLIC ISSUES BIOTECHNOL, ASM ARCHIVES, CTR HIST MICROBIOL, UNIV MARYLAND BALTIMORE CTY, PHYSICIANS HUMAN RIGHTS RP DALRYMPLE, JM (reprint author), USA,MED RES INST INFECT DIS,DIV VIROL,FT DETRICK,FREDERICK,MD 21702, USA. NR 0 TC 4 Z9 4 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA NEW YORK SN 0077-8923 BN 0-89766-745-X J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PY 1992 VL 666 BP 202 EP 218 DI 10.1111/j.1749-6632.1992.tb38031.x PG 17 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA BX95N UT WOS:A1992BX95N00014 PM 1297278 ER PT J AU VARADAN, VK GHODGAONKAR, DK VARADAN, VV KELLY, JF GLIKERDAS, P AF VARADAN, VK GHODGAONKAR, DK VARADAN, VV KELLY, JF GLIKERDAS, P TI CERAMIC PHASE SHIFTERS FOR ELECTRONICALLY STEERABLE ANTENNA SYSTEMS SO MICROWAVE JOURNAL LA English DT Article AB There is considerable interest in the development of microwave ceramic phase shifters because of limitations in the areas of cost, reliability and complexity of currently available ferrite and PIN diode phase shifters. This paper describes ceramic phase shifters that utilize a ferroelectric (Ba-Sr)TiO3 series material for obtaining phase shifts from changes in DC biasing fields. Also, the dielectric properties were measured as a function of DC biasing fields, frequency and temperature for several compositions of barium-strontium titanate material C1 USA,COMMUN & ELECTR COMMAND,FT MONMOUTH,NJ 07703. PENN STATE UNIV,ENGN ELECTR & ACOUST MAT RES CTR,UNIV PK,PA 16802. PENN STATE UNIV,DEPT ENGN SCI & MECH,UNIV PK,PA 16802. RP VARADAN, VK (reprint author), PENN STATE UNIV,ENGN SCI & ELECT ENGN,UNIV PK,PA 16802, USA. NR 9 TC 152 Z9 156 U1 0 U2 5 PU HORIZON HOUSE-MICROWAVE PI NORWOOD PA 685 CANTON ST, NORWOOD, MA 02062 SN 0192-6225 J9 MICROWAVE J JI Microw. J. PD JAN PY 1992 VL 35 IS 1 BP 116 EP & PG 0 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA HB941 UT WOS:A1992HB94100007 ER PT J AU SHANKS, GD BOSLEGO, J AF SHANKS, GD BOSLEGO, J TI TREATMENT OF MALARIA ACQUIRED IN SOUTHEAST-ASIA SO MILITARY MEDICINE LA English DT Article RP SHANKS, GD (reprint author), USA,MED COMPONENT,ARMED FORCES RES INST MED SCI,APO,SAN FRANCISCO,CA 96346, USA. RI Shanks, George Dennis/F-4056-2014 OI Shanks, George Dennis/0000-0001-5763-8660 NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JAN PY 1992 VL 157 IS 1 BP 4 EP 6 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA GZ717 UT WOS:A1992GZ71700007 ER PT J AU SIMPSON, MB YOUNG, DC BUCKNELL, AL AF SIMPSON, MB YOUNG, DC BUCKNELL, AL TI THE INCIDENCE OF PERMANENT UPPER AND LOWER-EXTREMITY PROFILES IN ACTIVE DUTY ARMY OFFICERS SO MILITARY MEDICINE LA English DT Article AB The records of 89,955 active duty Army officers were reviewed to determine their incidence of permanent upper and lower extremity profiles. Only 1,706 officers (1.897%) have permanent upper or lower extremity profiles. However, the incidence of such profiles varies with respect to rank, branch, and sex. Some officer groups have an incidence as high as 37%. Although the overall incidence of such profiles is quite low, the dramatically increased incidence in some officer groups demands scrutiny. RP SIMPSON, MB (reprint author), BROOKE ARMY MED CTR,DEPT SURG,ORTHOPAED SURG SERV,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JAN PY 1992 VL 157 IS 1 BP 17 EP 21 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA GZ717 UT WOS:A1992GZ71700011 PM 1603371 ER PT J AU SHATZ, DV AF SHATZ, DV TI INVASIVE PRESSURE MONITORING IN COMBAT MEDICAL FACILITIES - A PLEA FOR SOPHISTICATION SO MILITARY MEDICINE LA English DT Letter RP SHATZ, DV (reprint author), MEDDAC,GEN SURG SERV,FT SILL,OK 73503, USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JAN PY 1992 VL 157 IS 1 BP A5 EP A6 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA GZ717 UT WOS:A1992GZ71700004 PM 1603366 ER PT J AU JABBARI, B PAUL, J SCHEROKMAN, B VANDAM, B AF JABBARI, B PAUL, J SCHEROKMAN, B VANDAM, B TI POSTTRAUMATIC SEGMENTAL AXIAL DYSTONIA SO MOVEMENT DISORDERS LA English DT Note DE AXIAL DYSTONIA; SCOLIOSIS; BASAL GANGLIA; HEAD INJURY; TRIHEXYPHENIDYL AB Isolated dystonia of trunk and neck muscles without involvement elsewhere has been termed segmental axial dystonia-a rare disorder. We report a 3 1-year-old man who developed marked dystonia of paraspinal muscles and progressive scoliosis 6 months after a closed head injury. Computed tomography (CT) disclosed three small areas of encephalomalacia, one involving the head of the caudate nucleus. Treatment with trihexyphenidyl resulted in significant improvement of the dystonia and scoliosis. RP JABBARI, B (reprint author), WALTER REED ARMY MED CTR,NEUROL SERV,WASHINGTON,DC 20307, USA. NR 0 TC 19 Z9 19 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0885-3185 J9 MOVEMENT DISORD JI Mov. Disord. PD JAN PY 1992 VL 7 IS 1 BP 78 EP 81 DI 10.1002/mds.870070116 PG 4 WC Clinical Neurology SC Neurosciences & Neurology GA GW641 UT WOS:A1992GW64100014 PM 1557070 ER PT J AU CARR, LW YU, YH AF CARR, LW YU, YH TI THE USE OF INTERFEROMETRY IN THE STUDY OF ROTORCRAFT AERODYNAMICS SO OPTICS AND LASERS IN ENGINEERING LA English DT Article ID DYNAMIC STALL; AIRFOIL AB The application of interferometry techniques to analysis of aerodynamic flows on rotorcraft is reviewed, with emphasis on those studies which give insight into the character of the complex flows on helicopter rotor blades. In particular, blade-vortex interaction, dynamic stall, and transonic flow on rotor blades are reviewed, showing how interferometry offers new insight into the basic flow characteristics of these flows and presenting some of the correlations that have been made with the results of computational analysis. RP CARR, LW (reprint author), USA,ATCOM,NASA AMES RES CTR,AEROFLIGHTDYNAM DIRECTORATE,DIV FLUID MECH,MOFFETT FIELD,CA 94035, USA. NR 14 TC 2 Z9 2 U1 1 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0143-8166 J9 OPT LASER ENG JI Opt. Lasers Eng. PY 1992 VL 17 IS 3-5 BP 121 EP 146 DI 10.1016/0143-8166(92)90032-3 PG 26 WC Optics SC Optics GA KB036 UT WOS:A1992KB03600002 ER PT J AU HAMILTON, JN THOMPSON, SH SCHEIDT, MJ MCQUADE, MJ VANDYKE, T PLOWMAN, K AF HAMILTON, JN THOMPSON, SH SCHEIDT, MJ MCQUADE, MJ VANDYKE, T PLOWMAN, K TI CORRELATION OF SUBCLINICAL CANDIDAL COLONIZATION OF THE DORSAL TONGUE SURFACE WITH THE WALTER REED STAGING SCHEME FOR PATIENTS INFECTED WITH HIV-1 SO ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS LA English DT Article ID HIGH-RISK; CANDIDIASIS; ALBICANS; AIDS AB The correlation between subclinical candidal colonization of the dorsal tongue surface and the Walter Reed staging scheme for patients positive for human immunodeficiency virus (HIV-1) antibody is reported. Of 76 cytologic smears of the dorsal tongue surface, 12 (16.2%) demonstrated subclinical colonization. The mean peripheral helper T-lymphocyte count for patients with subclinical colonization was 304 +/- 226 cells/mm3 and was not significantly different from seropositive patients without colonization (411 +/- 209 cells/mm3). The Walter Reed scheme for assessing progressive immunodysregulation did not significantly correlate with the presence of subclinical colonization. This study suggests a more complex pathogenesis for oral candidiasis in HIV-1-infected patients rather than a direct link to peripheral helper T-lymphocyte depletion below a count of 400 cells/mm3. C1 USA DENTAC,PERIODONT RESIDENCY PROGRAM,FT HOOD,TX. DWIGHT D EISENHOWER ARMY MED CTR,FT GORDON,GA 30905. NR 17 TC 8 Z9 8 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 1079-2104 J9 ORAL SURG ORAL MED O JI Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. PD JAN PY 1992 VL 73 IS 1 BP 47 EP 51 DI 10.1016/0030-4220(92)90152-G PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HA456 UT WOS:A1992HA45600009 PM 1534883 ER PT J AU SMITH, BE THALER, MN AF SMITH, BE THALER, MN TI DETACHED ROOT APEXOGENESIS SO ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS LA English DT Note RP SMITH, BE (reprint author), USA,DENT ACTIV,FT HOOD,TX 76544, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 1079-2104 J9 ORAL SURG ORAL MED O JI Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. PD JAN PY 1992 VL 73 IS 1 BP 129 EP 129 DI 10.1016/0030-4220(92)90173-N PG 1 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HA456 UT WOS:A1992HA45600028 PM 1603555 ER PT J AU BURGESS, LPA DERDERIAN, SS MORIN, GV GONZALEZ, C ZAJTCHUK, JT AF BURGESS, LPA DERDERIAN, SS MORIN, GV GONZALEZ, C ZAJTCHUK, JT TI POSTOPERATIVE RISK FOLLOWING UVULOPALATOPHARYNGOPLASTY FOR OBSTRUCTIVE SLEEP-APNEA SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article ID COMPLICATIONS AB A study was conducted to assess oxygenation and respiratory changes on the first and second postoperative nights after uvulopalatopharyngoplasty (UPPP) for obstructive sleep apnea (OSA). Twelve patients were postoperatively evaluated with 8-hour nocturnal polysomnography on four occasions: (1) PREOP-night before UPPP, (2) POPN1-first postoperative night, (3) POPN2-second postoperative night, and (4) 3MOS-3-month follow-up study. Results demonstrate that apnea index (Al) and respiratory disturbance index (RDI) were significantly improved at 3MOS from PREOP levels: Al (p < 0.01) and RDI (p < 0.05). There were no statistical differences from PREOP to POPN1 or POPN2 for Al, RDI, lowest oxyhemoglobin saturation (LSAT), or number of desaturations (#DESAT). One of twelve patients dropped LSAT > 10% from PREOP to POPN1 or POPN2 (82% PREOP to 71% POPN2). Patients were grouped by PREOP LSAT greater-than-or-equal-to 80% or < 80%, and the postoperative change in LSAT was evaluated by comparing PREOP to a value averaging POPN1 and POPN2. Patients with LSAT greater-than-or-equal-to 80% decreased by 2.6%; patients with LSAT < 80% improved by 6.2%. This change in LSAT between groups was statistically different (p = 0.02). These data suggest that in the majority of patients, preoperative indices remain unchanged for at least 2 days after surgery, even for patients who demonstrated improvement at 3 months. However, worsening does occur in some patients. On the basis of the results of this study and clinical experience with the postoperative course, a selective management protocol is outlined. C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. RP BURGESS, LPA (reprint author), TRIPLER ARMY MED CTR,OTOLARYNGOL HEAD & NECK SURG SERV,HONOLULU,HI 96859, USA. NR 12 TC 35 Z9 37 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD JAN PY 1992 VL 106 IS 1 BP 81 EP 86 PG 6 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA GZ508 UT WOS:A1992GZ50800027 PM 1734375 ER PT J AU DUBEY, JP PETERS, D BROWN, C AF DUBEY, JP PETERS, D BROWN, C TI AN UNIDENTIFIED TOXOPLASMA-LIKE TISSUE CYST-FORMING COCCIDIUM IN A CAT (FELIS-CATUS) SO PARASITOLOGY RESEARCH LA English DT Article ID GONDII; MICE AB An unidentified coccidium was found in the brain and the heart of a 6-year-old female cat. Tissue cysts measured 40-130 x 40-112-mu-m and contained hundreds of bradyzoites measuring 4.2-5.2 x 1.2-1.8-mu-m. The cyst wall was 0.26-0.53-mu-m thick. Tissue cysts reacted positively with anti-Toxoplasma gondii serum but not with anti-Neospora caninum serum in an immunohistochemical test. Ultrastructurally, the cyst was aseptate and contained banana-shaped bradyzoites. Micronemes and rhoptries in bradyzoites were unlike those found in T. gondii bradyzoites. In the unidentified coccidium, the micronemes were arranged in rows and the rhoptries extended from the anterior tip to the posterior end. C1 USA,INST INFECT DIS,FT DETRICK,MD 21702. CORNELL UNIV,COLL VET MED,DEPT VET PATHOL,ITHACA,NY 14853. RP DUBEY, JP (reprint author), USDA ARS,BELTSVILLE AGR RES CTR,INST LIVESTOCK & POULTRY SCI,ZOONOT DIS LAB,BELTSVILLE,MD 20705, USA. NR 8 TC 3 Z9 3 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0044-3255 J9 PARASITOL RES JI Parasitol. Res. PD JAN PY 1992 VL 78 IS 1 BP 39 EP 42 DI 10.1007/BF00936179 PG 4 WC Parasitology SC Parasitology GA GT068 UT WOS:A1992GT06800007 PM 1584745 ER PT J AU CASTRO, CA LARSEN, T FINGER, AV SOLANA, RP MCMASTER, SB AF CASTRO, CA LARSEN, T FINGER, AV SOLANA, RP MCMASTER, SB TI BEHAVIORAL EFFICACY OF DIAZEPAM AGAINST NERVE AGENT EXPOSURE IN RHESUS-MONKEYS SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR LA English DT Article DE SERIAL PROBE RECOGNITION (SPR); DIAZEPAM; NERVE AGENTS; SOMAN; CONVULSIONS; RHESUS MONKEYS; COGNITION; ORGANOPHOSPHATE ID INDUCED SEIZURE ACTIVITY; SOMAN; RECOGNITION; MEMORY; PRETREATMENT; CONVULSIONS; PROTECTION; LISTS AB The possibility that nerve agents will be used on the battlefield is real. The traditional therapy against nerve agent exposure consists of pyridostigmine pretreatment and atropine-pralidoxime chloride therapy administered after nerve agent exposure. This therapy regimen is extremely effective in preventing mortality in laboratory animals exposed to multilethal concentrations of nerve agent, yet these animals often display convulsions, brain damage, and behavioral incapacitation. We report here that the addition of diazepam to the traditional therapy for nerve agent (soman) exposure not only decreases the incidence of convulsions, but also attenuates the cognitive impairments of rhesus monkeys trained on a Serial Probe Recognition (SPR) task. Monkeys which received diazepam treatment required only 6 days before their performance on the SPR task returned to presoman exposure levels, compared to nondiazepam-treated monkeys which required 15 days. Moreover, only 1 out of the 5 monkeys which received diazepam treatment suffered tonic-clonic convulsions; in contrast all 5 monkeys which did not receive diazepam treatment experienced severe convulsive episodes. These results suggest that diazepam would be an excellent adjunct to traditional nerve agent therapy to facilitate behavioral recovery from nerve agent intoxication that might be encountered by US military personnel on the battlefield or accidental organophosphate poisoning encountered in industrial or agricultural accidents. RP CASTRO, CA (reprint author), USA,MED RES INST CHEM DEF,SGRD UV DA,ABERDEEN PROVING GROUND,MD 21010, USA. NR 25 TC 16 Z9 16 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0091-3057 J9 PHARMACOL BIOCHEM BE JI Pharmacol. Biochem. Behav. PD JAN PY 1992 VL 41 IS 1 BP 159 EP 164 DI 10.1016/0091-3057(92)90076-R PG 6 WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy GA GW866 UT WOS:A1992GW86600027 PM 1539066 ER PT J AU JOHNSON, JP AF JOHNSON, JP TI CELLULAR MECHANISMS OF ACTION OF MINERALOCORTICOID HORMONES SO PHARMACOLOGY & THERAPEUTICS LA English DT Review ID TOAD URINARY-BLADDER; NA-K-ATPASE; CORTICAL COLLECTING DUCT; ALDOSTERONE-INDUCED PROTEINS; CULTURED EPITHELIAL-CELLS; SENSITIVE SODIUM-CHANNEL; APICAL MEMBRANE-VESICLES; RABBIT NEPHRON SEGMENTS; THICK ASCENDING LIMB; RAT-KIDNEY AB Mineralocorticoid hormones are a subset of steroid hormones that act primarily in epithelial tissues to regulate ion transport of Na+, K+ and H+. Cellular specificity is conferred by receptors which act in the nucleus to stimulate gene expression. Transcription and subsequent translation result in the production of new proteins which mediate the physiologic effects. The mechanisms involved in receptor specificity and localization, in regulation of gene activation, and in expression of transport effects are reviewed. The cellular actions of mineralocorticoids fit well with the general model of steroid hormone action but considerable questions remain at each step in the process. C1 WALTER REED ARMY MED CTR,DEPT NEPHROL,WASHINGTON,DC 20307. NR 222 TC 29 Z9 29 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0163-7258 J9 PHARMACOL THERAPEUT JI Pharmacol. Ther. PY 1992 VL 53 IS 1 BP 1 EP 29 DI 10.1016/0163-7258(92)90042-X PG 29 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA JB856 UT WOS:A1992JB85600001 PM 1322539 ER PT J AU BROOMFIELD, CA AF BROOMFIELD, CA TI A PURIFIED RECOMBINANT ORGANOPHOSPHORUS ACID ANHYDRASE PROTECTS MICE AGAINST SOMAN SO PHARMACOLOGY & TOXICOLOGY LA English DT Article ID PARATHION HYDROLASE GENE; PSEUDOMONAS-DIMINUTA; NERVE AGENTS; DETOXIFICATION; EXPRESSION AB Since pharmacologic treatments of organophosphorus anticholinesterases (OPs) are nearing their practical limit other types of treatment are being sought. One approach is the prophylactic administration of scavengers that will detoxify OPs before they reach their critical target site. Using mice that were sensitized to OPs by depletion of their serum carboxylesterase with cresylbenzodioxaphosphorin oxide (CBDP), we have shown that animals pretreated intravenously with a purified organophosphorus acid anhydride hydrolase (parathionase) (0.10 mg per g body wt.) are not measurably affected by up to 34.4-mu-g soman per kg, a dose more than double that which is lethal to untreated animals. This result indicates that this approach is worthy of exploration and development for protecting military personnel and agricultural workers against OP intoxication. RP BROOMFIELD, CA (reprint author), USA,MED RES INST CHEM DEF,BIOCHEM PHARMACOL BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 14 TC 30 Z9 31 U1 0 U2 0 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0901-9928 J9 PHARMACOL TOXICOL JI Pharmacol. Toxicol. PD JAN PY 1992 VL 70 IS 1 BP 65 EP 66 PG 2 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA GZ847 UT WOS:A1992GZ84700013 PM 1317565 ER PT J AU SCOVILL, JP AF SCOVILL, JP TI A CONVENIENT METHOD FOR THE SYNTHESIS OF 6-SELENOPURINE RIBOSIDES SO PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS LA English DT Article DE 6-SELENOINOSINE; 6-SELENOGUANOSINE; SODIUM HYDROGEN SELENIDE; NUCLEOPHILIC DISPLACEMENT REACTION; CONVENIENT SYNTHESIS ID SODIUM AB A convenient method for the synthesis of 6-selenopurine ribosides by nucleophilic displacement of chloride by sodium hydrogen selenide from the corresponding 6-chloropurine ribosides is described. This method provides a useful improvement in yield while significantly simplifying the literature procedures. RP SCOVILL, JP (reprint author), USA,MED RES INST INFECT DIS,DIV TOXINOL,FT DETRICK,FREDERICK,MD 21702, USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU GORDON BREACH SCI PUBL LTD PI READING PA C/O STBS LTD PO BOX 90, READING, BERKS, ENGLAND RG1 8JL SN 0308-664X J9 PHOSPHORUS SULFUR JI Phosphorus Sulfur Silicon Relat. Elem. PY 1992 VL 70 IS 1-2 BP 1 EP 2 DI 10.1080/10426509208049143 PG 2 WC Chemistry, Inorganic & Nuclear; Chemistry, Organic SC Chemistry GA JU642 UT WOS:A1992JU64200001 ER PT J AU YEH, HR AF YEH, HR TI FORMATION OF SULFOXIDE DIMERS FROM HYDROGEN-PEROXIDE OXIDATION OF 2-CHLOROETHYL METHYL SULFIDE AND 2-CHLOROETHYL ETHYL SULFIDE SO PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS LA English DT Article DE HYDROGEN PEROXIDE OXIDATION; FORMATION OF ATYPICAL SULFOXIDE DIMERS; 2-CHLOROETHYL ETHYL SULFIDE; 2-CHLOROETHYL METHYL SULFIDE; THIODIGLYCOL ID ORGANOSULFUR COMPOUNDS; ANTIMICROBIAL SYSTEM; MASS-SPECTROMETRY; DERIVATIVES; MECHANISM RP YEH, HR (reprint author), USA,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010, USA. NR 20 TC 1 Z9 1 U1 1 U2 2 PU GORDON BREACH SCI PUBL LTD PI READING PA C/O STBS LTD PO BOX 90, READING, BERKS, ENGLAND RG1 8JL SN 0308-664X J9 PHOSPHORUS SULFUR JI Phosphorus Sulfur Silicon Relat. Elem. PY 1992 VL 68 IS 1-4 BP 1 EP 7 DI 10.1080/10426509208038365 PG 7 WC Chemistry, Inorganic & Nuclear; Chemistry, Organic SC Chemistry GA HW754 UT WOS:A1992HW75400001 ER PT J AU NORVELLE, FR AF NORVELLE, FR TI STEREO CORRELATION - WINDOW SHAPING AND DEM CORRECTIONS SO PHOTOGRAMMETRIC ENGINEERING AND REMOTE SENSING LA English DT Article AB The accuracy of digital elevation models (DEMs), extracted automatically from terrain images using digital correlation methods, can be enhanced by performing simple, linear, window shaping operations within the correlation method. Window shaping reduces the size and shape differences between small corresponding areas on stereoimages and contributes to a more accurate determination of stereoimage correspondence and, consequently, DEM values. The slow and tedious process of DEM editing can be expedited by taking advantage of the geometric relationship between orthophotographs and the DEMs that are used to produce them. For example, a pair of digital orthophotos, supposedly identical, can be generated from each of the original stereoimages that were used to create the DEM in the first place. The mismatches in the pair of orthophotos can be measured automatically with a digital correlation method, converted to equivalent elevation errors, and used to correct the original DEM. RP NORVELLE, FR (reprint author), USA,ENGINEER TOPOG LABS,RES INST,FT BELVOIR,VA 22060, USA. NR 2 TC 7 Z9 7 U1 0 U2 0 PU AMER SOC PHOTOGRAMMETRY PI BETHESDA PA 5410 GROSVENOR LANE SUITE 210, BETHESDA, MD 20814-2160 SN 0099-1112 J9 PHOTOGRAMM ENG REM S JI Photogramm. Eng. Remote Sens. PD JAN PY 1992 VL 58 IS 1 BP 111 EP 115 PG 5 WC Geography, Physical; Geosciences, Multidisciplinary; Remote Sensing; Imaging Science & Photographic Technology SC Physical Geography; Geology; Remote Sensing; Imaging Science & Photographic Technology GA GX509 UT WOS:A1992GX50900012 ER PT J AU KRIEGER, JB YAN, L IAFRATE, GJ AF KRIEGER, JB YAN, L IAFRATE, GJ TI CONSTRUCTION AND APPLICATION OF AN ACCURATE LOCAL SPIN-POLARIZED KOHN-SHAM POTENTIAL WITH INTEGER DISCONTINUITY - EXCHANGE-ONLY THEORY SO PHYSICAL REVIEW A LA English DT Article ID DENSITY-FUNCTIONAL THEORY; SELF-INTERACTION CORRECTION; DERIVATIVE DISCONTINUITIES; ENERGY; ATOMS; APPROXIMATIONS; SYSTEMS AB An accurate spin-polarized exchange-only Kohn-Sham (KS) potential is constructed from a consideration of the optimized-effective-potential (OEP) method. A detailed analysis of the OEP integral equation for the exchange-only case results in a set of conditions which are manifestly satisfied by the exact OEP; these conditions are employed to construct an approximate OEP, V(x-sigma) and therefore an approximate KS exchange-only potential as a functional of KS orbitals. Further, it is shown that this V(x-sigma) can be derived analytically based on a simple approximation of the Green's functions in the OEP integral equation. The constructed potential, although approximate, contains many of the key analytic features of the exact KS potential: it reduces to the exact KS result in the homogeneous-electron-gas limit, approaches -1/r as r --> infinity, yields highest occupied-orbital energy eigenvalues epsilon(m-sigma) that satisfy Koopmans's theorem, and exhibits an integer discontinuity when considered as a function of fractional occupancy of the highest-energy occupied single-particle state of a given spin projection-sigma. In addition epsilon(m-sigma) nearly exactly satisfies Janak's theorem. The approximate OEP is a simple but remarkably accurate representation of the exact, numerically derived exchange-only OEP. Detailed numerical results obtained by employing V(x-sigma) as the exchange-only potential for ten atoms with closed subshells yield total energies, Hartree potentials, single-particle expectation values, and epsilon(m) which are in excellent agreement with both exact OEP and Hartree-Fock (HF) results and represent a significant improvement over the results obtained by employing other exchange-only potentials. Similarly, the properties of alkali-metal atoms are calculated including the separate spin-up and spin-down densities to obtain results in excellent agreement with those of spin-unrestricted OEP and HF methods. Finally, we demonstrate the accuracy of V(x-sigma) by calculating the total energy, epsilon(m up), and epsilon(m down) as a function of fractional filling f, of the highest occupied single-particle orbital for the magnesium atom (Z = 12) from N = 9-12 electrons and find excellent agreement with both spin-unrestricted OEP and HF results even when epsilon(m-sigma) is strongly dependent on f. In addition we display the integer discontinuity in V(x-sigma) when the highest-energy spin subshell begins to be filled. C1 USA, RES OFF, RES TRIANGLE PK, NC 27709 USA. RP CUNY BROOKLYN COLL, DEPT PHYS, BROOKLYN, NY 11210 USA. NR 37 TC 518 Z9 521 U1 4 U2 22 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 EI 1094-1622 J9 PHYS REV A JI Phys. Rev. A PD JAN 1 PY 1992 VL 45 IS 1 BP 101 EP 126 DI 10.1103/PhysRevA.45.101 PG 26 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA GY518 UT WOS:A1992GY51800018 ER PT J AU BLATT, FJ AF BLATT, FJ TI BLATT,JOHN,M - OBITUARY SO PHYSICS TODAY LA English DT Item About an Individual RP BLATT, FJ (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0031-9228 J9 PHYS TODAY JI Phys. Today PD JAN PY 1992 VL 45 IS 1 BP 84 EP 84 DI 10.1063/1.2809506 PG 1 WC Physics, Multidisciplinary SC Physics GA HA079 UT WOS:A1992HA07900013 ER PT J AU BAUMAN, RA KANT, GJ AF BAUMAN, RA KANT, GJ TI CIRCADIAN EFFECTS OF ESCAPABLE AND INESCAPABLE SHOCK ON THE FOOD-INTAKE AND WHEELRUNNING OF RATS SO PHYSIOLOGY & BEHAVIOR LA English DT Article DE CHRONIC STRESS; FEEDING; WHEELRUNNING; RAT ID PITUITARY CYCLIC-AMP; LEARNED HELPLESSNESS; CHRONIC STRESS; BODY-WEIGHT; MACRONUTRIENT SELECTION; PLASMA-CORTICOSTERONE; BEHAVIORAL DEPRESSION; RESTRAINT STRESS; BETA-ENDORPHIN; PROLACTIN AB The feeding and running activities of rats were used to characterize the stressful effects of footshock. A 12-hour light/dark cycle was continuously in effect. During the preshock stage, all rats lived in individual cages where they could drink water, press a lever once for each 45 mg food pellet or run in an attached running wheel. During the shock stage, rats were moved to cages where they could drink and eat, but not run. Five s of light followed by 5 s of a light + tone compound preceded five progressively more intense shock levels. Rats in group AE were trained to pull a ceiling chain to avoid/escape from footshocks that were scheduled 24 hours per day. In group YS, the frequency, intensity and pattern of shocks for a rat were yoked to a rat in group AE. Rats in group CN were not shocked. During recovery, rats were allowed to resume running. During the dark, but not the light of the first day of shock, the intake of groups AE and YS was less than the intake of group CN. By the third day of shock, the food intake of group AE recovered and was no longer different from the intake of group CN. Intake of group YS remained less than the intakes of groups AE and CN during the remainder of the shock stage. When shock was terminated, the intake of the YS group recovered, but neither running nor food intake differed among groups. These results suggest that although inescapable shock disrupts food intake more than escapable shock, this disruption is specific to the duration of the shock stage and depends on rat's circadian pattern of intake. RP BAUMAN, RA (reprint author), WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,PHYSIOL & BEHAV BRANCH,WASHINGTON,DC 20307, USA. NR 35 TC 5 Z9 5 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0031-9384 J9 PHYSIOL BEHAV JI Physiol. Behav. PD JAN PY 1992 VL 51 IS 1 BP 167 EP 174 DI 10.1016/0031-9384(92)90219-R PG 8 WC Psychology, Biological; Behavioral Sciences SC Psychology; Behavioral Sciences GA GX683 UT WOS:A1992GX68300024 PM 1741444 ER PT J AU HSIEH, AJ DESPER, CR SCHNEIDER, NS AF HSIEH, AJ DESPER, CR SCHNEIDER, NS TI TRANSIENT CRYSTALLIZATION OF AN AROMATIC POLYETHERIMIDE - EFFECT OF ANNEALING SO POLYMER LA English DT Article DE POLYETHERIMIDE; CRYSTALLIZATION; CRYSTALLINITY; ANNEALING; CALORIMETRY; PHASE TRANSFORMATION AB A systematic study using differential scanning calorimetry has been performed on the annealing behaviour of an aromatic polyetherimide (Ultem 5001). Although crystallization from the melt did not occur. crystallinity was easily induced in the presence of methylene chloride. With annealing, a sharp melt endotherm of the solvent-treated polyetherimide was observed. The melt temperature determined after annealing for 30 min increased progressively as the annealing temperature increased, leading to an extrapolation to an apparent equilibrium melt temperature of 369-degrees-C. However, the melt temperature, as well as crystallinity, increased with the increase of the residence time at each annealing temperature. X-ray diffraction data revealed two distinct crystalline phases; a low temperature (alpha) phase obtained by crystallization for 30 min at 248 and 258-degrees-C, and a high temperature (beta) phase obtained at 258-degrees-C for 3 h or exceeding 258-degrees-C. Values of heat of fusion per gram of crystallite were consistent with a range of 247-261 J g-1 for the samples of higher crystallinity. RP HSIEH, AJ (reprint author), USA,MAT TECHNOL LAB,SLCMT,EMP,WATERTOWN,MA 02172, USA. NR 24 TC 9 Z9 9 U1 1 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0032-3861 J9 POLYMER JI Polymer PY 1992 VL 33 IS 2 BP 306 EP 313 DI 10.1016/0032-3861(92)90987-8 PG 8 WC Polymer Science SC Polymer Science GA HB161 UT WOS:A1992HB16100012 ER PT B AU JOHNSON, LD AF JOHNSON, LD GP ASCE, GEOTECH DIV TI WAVE ANALYSIS OF FOUNDATIONS ON SWELLING SOILS SO PROCEEDINGS OF THE 7TH INTERNATIONAL CONFERENCE ON EXPANSIVE SOILS, VOL 1 LA English DT Proceedings Paper CT 7th International Conference on Expansive Soils CY AUG 03-05, 1992 CL DALLAS, TX SP ASCE GEOTECHN DIV, ASCE COMM SHALLOW FDN, ASCE COMM SOIL PROPERTIES, INT SOC SOIL MECH & FDN ENGN, TRANSPORTAT RES BOARD COMM A2L06, NATL SCI FDN, TEXAS TECH UNIV C1 USA,ENGINEER WATERWAYS EXPT STN,VICKSBURG,MS 39180. NR 0 TC 0 Z9 0 U1 0 U2 0 PU TEXAS TECH UNIV PRESS PI LUBBOCK PA PO BOX 4139, LUBBOCK, TX 79409 PY 1992 BP 375 EP 380 PG 6 WC Engineering, Civil SC Engineering GA BB63V UT WOS:A1992BB63V00070 ER PT B AU PETERSON, RW AF PETERSON, RW GP ASCE, GEOTECH DIV TI SHEAR-STRENGTH OF UNSATURATED SOIL SO PROCEEDINGS OF THE 7TH INTERNATIONAL CONFERENCE ON EXPANSIVE SOILS, VOL 2 LA English DT Proceedings Paper CT 7th International Conference on Expansive Soils CY AUG 03-05, 1992 CL DALLAS, TX SP ASCE GEOTECHN DIV, ASCE COMM SHALLOW FDN, ASCE COMM SOIL PROPERTIES, INT SOC SOIL MECH & FDN ENGN, TRANSPORTAT RES BOARD COMM A2L06, NATL SCI FDN, TEXAS TECH UNIV C1 USA,WATERWAYS EXPT STN,GEOTECH LAB,VICKSBURG,MS 39180. NR 0 TC 0 Z9 0 U1 0 U2 0 PU TEXAS TECH UNIV PRESS PI LUBBOCK PA PO BOX 4139, LUBBOCK, TX 79409 PY 1992 BP 89 EP 94 PG 6 WC Engineering, Civil SC Engineering GA BB63W UT WOS:A1992BB63W00007 ER PT J AU SCHWERING, FK AF SCHWERING, FK TI MILLIMETER-WAVE ANTENNAS SO PROCEEDINGS OF THE IEEE LA English DT Article ID PRINTED-CIRCUIT ANTENNAS; MICROSTRIP ANTENNAS; ARRAY ANTENNAS; IMAGING ARRAYS AB Major advances in mm-wave antennas have been made in recent years in particular in two areas. A new class of leaky-wave antennas based on open mm-waveguides has been proposed and investigated; and substantial progress has been achieved in integrated antennas where active and passive circuits, possibly in monolithic form, are combined with the radiating elements in one compact unit. Interesting developments have taken place also in a third group of mm-wave antennas, that of microstrip antennas and printed circuit antennas in general. An attempt is made to summarize these developments. RP SCHWERING, FK (reprint author), USA,CECOM,FT MONMOUTH,NJ 07703, USA. NR 59 TC 27 Z9 27 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9219 J9 P IEEE JI Proc. IEEE PD JAN PY 1992 VL 80 IS 1 BP 92 EP 102 DI 10.1109/5.119569 PG 11 WC Engineering, Electrical & Electronic SC Engineering GA HE999 UT WOS:A1992HE99900007 ER PT J AU LONDON, SD SCHMALJOHN, AL DALRYMPLE, JM RICE, CM AF LONDON, SD SCHMALJOHN, AL DALRYMPLE, JM RICE, CM TI INFECTIOUS ENVELOPED RNA VIRUS ANTIGENIC CHIMERAS SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE ALPHAVIRUSES; RANDOM MUTAGENESIS; VIRUS VECTORS; PROTEIN ENGINEERING; GLYCOPROTEINS ID VALLEY FEVER VIRUS; COMPLETE NUCLEOTIDE-SEQUENCE; AMINO-ACID SEQUENCES; SINDBIS VIRUS; MONOCLONAL-ANTIBODIES; STRUCTURAL PROTEINS; INVITRO MUTAGENESIS; CONSTRUCTED INVITRO; CIRCULAR DNA; POLIOVIRUS AB Random insertion mutagenesis has been used to construct infectious Sindbis virus structural protein chimeras containing a neutralization epitope from a heterologous virus, Rift Valley fever virus. Insertion sites, permissive for recovery of chimeric viruses with growth properties similar to the parental virus, were found in the virion E2 glycoprotein and the secreted E3 glycoprotein. For the E2 chimeras, the epitope was expressed on the virion surface and stimulated a partially protective immune response to Rift Valley fever virus infection in vivo. Besides providing a possible approach for developing live attenuated vaccine viruses, insertion of peptide ligands into virion surface proteins may ultimately allow targeting of virus infection to specific cell types. C1 WASHINGTON UNIV,SCH MED,DEPT MOLEC MICROBIOL,660 S EUCLID AVE,BOX 8230,ST LOUIS,MO 63110. USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. FU NIAID NIH HHS [AI24134] NR 44 TC 51 Z9 53 U1 1 U2 7 PU NATL ACAD PRESS PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD JAN 1 PY 1992 VL 89 IS 1 BP 207 EP 211 DI 10.1073/pnas.89.1.207 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA GY047 UT WOS:A1992GY04700044 PM 1370348 ER PT J AU FRIES, LF GORDON, DM RICHARDS, RL EGAN, JE HOLLINGDALE, MR GROSS, M SILVERMAN, C ALVING, CR AF FRIES, LF GORDON, DM RICHARDS, RL EGAN, JE HOLLINGDALE, MR GROSS, M SILVERMAN, C ALVING, CR TI LIPOSOMAL MALARIA VACCINE IN HUMANS - A SAFE AND POTENT ADJUVANT STRATEGY SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article ID PLASMODIUM-FALCIPARUM MALARIA; ESCHERICHIA-COLI; LIPID-A; CIRCUMSPOROZOITE PROTEIN; SPOROZOITE VACCINE; ALUMINUM HYDROXIDE; IMMUNE-RESPONSE; ANTIGEN; IMMUNOGENICITY; EXPRESSION AB This study describes the safety and immunogenicity of a liposome-based vaccine injected into human subjects. Thirty healthy adult male volunteers were immunized with a liposome-encapsulated recombinant protein (R32NS1(81)) containing epitopes from the repeat region of the circumsporozoite protein of Plasmodium falciparum. This antigen had previously been found to be poorly immunogenic in humans when it was adsorbed with Al(OH)3. In the present study, R32NS1(81) was encapsulated in liposomes containing monophosphoryl lipid A that were subsequently adsorbed to Al(OH)3. Increasing doses of liposomes containing antigen and monophosphoryl lipid A were used, but the liposomes were always adsorbed to the same dose of Al(OH)3. R32-specific serum IgG antibody responses to liposome-encapsulated R32NS1(81) were much higher than levels attained previously in humans with R32NS1(81) adsorbed to Al(OH)3. Geometric mean specific IgG levels after three doses ranged from 14 to 33-mu-g/ml. Sera from volunteers receiving the two highest doses inhibited P. falciparum sporozoite invasion of cultured hepatoma cells by an average of 92%, a result that was again superior to previously reported vaccines. Moderate but acceptable transient local reactogenicity was noted at high doses of the vaccine formulation, but little or no systemic toxicity was seen despite liposomal monophosphoryl lipid A doses up to 2200-mu-g. We conclude that encapsulation of poorly immunogenic circumsporozoite protein repeat peptides in monophosphoryl lipid A-containing liposomes is a successful adjuvant strategy in humans for inducing high levels of specific antibody production. C1 WALTER REED ARMY MED CTR,DEPT MEMBRANE BIOCHEM,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT IMMUNOL,WASHINGTON,DC 20307. JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,CTR IMMUNIZAT RES,BALTIMORE,MD 21205. SMITHKLINE BEECHAM PHARMACEUT,DEPT MOLEC GENET,KING OF PRUSSIA,PA 19406. SMITHKLINE BEECHAM PHARMACEUT,DEPT PROT CHEM,KING OF PRUSSIA,PA 19406. NR 31 TC 158 Z9 163 U1 2 U2 15 PU NATL ACAD PRESS PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD JAN 1 PY 1992 VL 89 IS 1 BP 358 EP 362 DI 10.1073/pnas.89.1.358 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA GY047 UT WOS:A1992GY04700075 PM 1729706 ER PT J AU REISS, EH AF REISS, EH GP CALIF STATE UNIV TI BATTERY APPLICATIONS IN THE ARMY SO PROCEEDINGS OF THE SEVENTH ANNUAL BATTERY CONFERENCE ON APPLICATIONS AND ADVANCES LA English DT Proceedings Paper CT 7th Annual Battery Conference on Applications and Advances CY JAN 21-23, 1992 CL LONG BEACH, CA SP CALIF STATE UNIV LONG BEACH, DEPT ELECT ENGN C1 USA,COMMAND LAB,DIV POWER SOURCES,SLCET PB,FT MONMOUTH,NJ 07703. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CALIFORNIA STATE UNIV CONSORTIUM PI LONG BEACH PA 1250 BELLFLOWER BLVD, LONG BEACH, CA 90840 PY 1992 BP 3 EP 8 PG 6 WC Electrochemistry; Engineering, Electrical & Electronic SC Electrochemistry; Engineering GA BZ58H UT WOS:A1992BZ58H00001 ER PT J AU FERRELL, O WHEELER, J AF FERRELL, O WHEELER, J GP CALIF STATE UNIV TI MASS BATTERY CHARGING SO PROCEEDINGS OF THE SEVENTH ANNUAL BATTERY CONFERENCE ON APPLICATIONS AND ADVANCES LA English DT Proceedings Paper CT 7th Annual Battery Conference on Applications and Advances CY JAN 21-23, 1992 CL LONG BEACH, CA SP CALIF STATE UNIV LONG BEACH, DEPT ELECT ENGN C1 USA,DUGWAY PROVING GROUND,MAT TEST DIRECTORATE,GRID SERV,DUGWAY PROVING GROUND,UT 84022. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CALIFORNIA STATE UNIV CONSORTIUM PI LONG BEACH PA 1250 BELLFLOWER BLVD, LONG BEACH, CA 90840 PY 1992 BP 33 EP 42 PG 10 WC Electrochemistry; Engineering, Electrical & Electronic SC Electrochemistry; Engineering GA BZ58H UT WOS:A1992BZ58H00004 ER PT J AU GRIMES, J SCHAUDIES, P DAVIS, D WILLIAMS, C CURRY, BJ WALKER, MD KOLDOVSKY, O AF GRIMES, J SCHAUDIES, P DAVIS, D WILLIAMS, C CURRY, BJ WALKER, MD KOLDOVSKY, O TI EFFECT OF SHORT-TERM FASTING REFEEDING ON EPIDERMAL GROWTH-FACTOR CONTENT IN THE GASTROINTESTINAL-TRACT OF SUCKLING RATS SO PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE LA English DT Article ID FACTOR EGF; MOUSE; MILK; LOCALIZATION; MUCOSA AB Epidermal growth factor (EGF) is trophic for varying regions of the developing gastrointestinal tract (GIT) of suckling rats. The presence of large amounts of EGF in milk from various species, combined with low production of EGF by suckling animals, led to speculation that milk is a major source of EGF for suckling rats. We report that short-term fasting (8 hr) of 12-day-old suckling rats resulted in a significant decrease in the levels of immunoreactive EGF (irEGF) in the GIT. Pups refed by lactating mothers for 1 to 4 hr exhibited an increase in irEGF to original levels, whereas pups fed a rat milk substitute by gastric gavage did not have an increase in irEGF content. The irEGF levels in the GIT of pups that were manually fed normal rat milk, or rat milk substitute supplemented with EGF, returned to the prefasted levels. Fasted suckling rats refed 2 ml of rat milk in 2 h exhibited significantly higher level of irEGF in the GIT than did those refed with 0.5 ml in 45 min. Since rat milk irEGF exists in three distinct forms (A, B, and C; C is equal to authentic submandibular gland EGF, the irEGF forms in the GIT were characterized by native polyacrylamide gel electrophoresis. In the stomach luminal contents of the fed suckling rats, only the larger form, Peak B, was observed. Both the luminal content and the mucosa scrapings of all other segments of all groups contained only Form D (comigrating with desarginyl EGF), a metabolic derivative of EGF. All forms were immunoreactive, exhibited receptor binding, and stimulated DNA synthesis in growth-arrested fibroblasts. The rapid changes in EGF within the GIT of suckling rats suggest the EGF can acutely modify some GIT functions of suckling rats. C1 UNIV ARIZONA,DEPT PEDIAT,1501 N CAMPBELL AVE,TUCSON,AZ 85724. UNIV ARIZONA,DEPT PHYSIOL,TUCSON,AZ 85724. UNIV ARIZONA,CHILDRENS RES CTR,TUCSON,AZ 85724. WALTER REED ARMY MED CTR,DEPT NEPHROL,WASHINGTON,DC 20307. FU NIDDK NIH HHS [DK 27624] NR 29 TC 11 Z9 12 U1 0 U2 0 PU BLACKWELL SCIENCE INC PI MALDEN PA 350 MAIN ST, MALDEN, MA 02148 SN 0037-9727 J9 P SOC EXP BIOL MED JI Proc. Soc. Exp. Biol. Med. PD JAN PY 1992 VL 199 IS 1 BP 75 EP 80 PG 6 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA GW106 UT WOS:A1992GW10600012 PM 1728040 ER PT J AU MOUL, JW FRIEDRICHS, PA LANCE, RS THEUNE, SM CHANG, EH AF MOUL, JW FRIEDRICHS, PA LANCE, RS THEUNE, SM CHANG, EH TI INFREQUENT RAS ONCOGENE MUTATIONS IN HUMAN PROSTATE-CANCER SO PROSTATE LA English DT Article DE POLYMERASE CHAIN REACTION; ARCHIVAL TISSUES; GENETIC ALTERATIONS; ONCOGENES ID POLYMERASE CHAIN-REACTION; TISSUE; ADENOCARCINOMA; SEQUENCES; VIRUS; DNA AB The RAS gene family includes three functional genes, H-RAS, K-RAS, and N-RAS, which have been most widely studied in human tumors. Point mutations most commonly occurring at codons 12, 13, or 61 of these genes allow the RAS protooncogene to be converted to a RAS oncogene. A variety of human tumors have been studied for RAS mutations to date, however. conflicting data has been reported regarding prostate cancer. Cell line studies and two American studies of clinical material have found a low incidence of RAS mutation in prostate cancer. The few mutations found were predominantly in the H-RAS gene. Conversely, a recent study of Japanese occult autopsy specimens found an approximate 25% incidence of K-RAS mutations. In this current study, DNA was extracted from 24 archival paraffin-embedded, formalin-fixed radical prostatectomy specimens. Twenty-one of the 24 cases had pathologic stage C disease, and paraffin blocks were selected having the most concentrated area of neoplasm. Twelve. seven, and five cases demonstrated moderate, well and poorly differentiated histologic grade respectively. Polymerase chain reaction (PCR) was used to amplify the K-RAS, N-RAS, and H-RAS 12, 13, 61 codons of these specimens and mutations were detected with mutation-specific oligonucleotide probe hybridization of southern and slot blots. No definite point mutations were detected. PCR's and hybridizations were performed three separate times by three investigators to confirm these results. PCR-generated mutation-specific positive controls and known negative controls were used and found to be important to interpret oligonucleotide hybridization assays. RAS gene mutations appear to be infrequent in clinical prostate carcinomas in American males. C1 WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT PATHOL,BETHESDA,MD 20814. RP MOUL, JW (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. NR 23 TC 86 Z9 88 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0270-4137 J9 PROSTATE JI Prostate PY 1992 VL 20 IS 4 BP 327 EP 338 DI 10.1002/pros.2990200407 PG 12 WC Endocrinology & Metabolism; Urology & Nephrology SC Endocrinology & Metabolism; Urology & Nephrology GA HZ984 UT WOS:A1992HZ98400006 PM 1608859 ER PT J AU LETALLEC, P MANI, S ROCHINHA, FA AF LETALLEC, P MANI, S ROCHINHA, FA TI FINITE-ELEMENT COMPUTATION OF HYPERELASTIC RODS IN LARGE DISPLACEMENTS SO RAIRO-MATHEMATICAL MODELLING AND NUMERICAL ANALYSIS-MODELISATION MATHEMATIQUE ET ANALYSE NUMERIQUE LA English DT Article AB The present paper deals with the Numerical Analysis of the equilibrium problem of an elastic rod subjected to very large displacements, involving traction, flexion and torsion. The model which is used describes the motion and the deformation of the rod by orthogonal directors, which leads to an hyperelastic problem written in an objective and intrinsic framework. This problem is then approximated by Mixed Finite Elements and the corresponding approximation is proved to be well posed and to produce solutions which strongly converge towards any isolated stable equilibrium position of the rod. Finally, the discrete problem is numerically solved by a Newton's type procedure which respects the orthogonality of the directors and the inextensibility of the rod. C1 FAC SCI TUNIS,DEPT MATH,TUNIS 10601,TUNISIA. INST POLITECN RIO DE JANEIRO,NOVA FRIBURGO,RJ,BRAZIL. STANFORD UNIV,DIV APPL MECH,STANFORD,CA 94305. UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55455. RP LETALLEC, P (reprint author), UNIV PARIS 09,CEREMADE,F-75576 PARIS 16,FRANCE. NR 9 TC 4 Z9 4 U1 0 U2 0 PU DUNOD PI MONTROUGE CEDEX PA 15 RUE GOSSIN, 92543 MONTROUGE CEDEX, FRANCE SN 0764-583X J9 RAIRO-MATH MODEL NUM JI Rairo-Math. Model. Numer. Anal.-Model. Math. Anal. Numer. PY 1992 VL 26 IS 5 BP 595 EP 625 PG 31 WC Mathematics, Applied SC Mathematics GA JJ294 UT WOS:A1992JJ29400003 ER PT J AU COLE, MW SALIMIAN, S COOPER, CB LEE, HS DUTTA, M AF COLE, MW SALIMIAN, S COOPER, CB LEE, HS DUTTA, M TI REACTIVE ION ETCHING OF GAAS WITH SICL4 - A RESIDUAL DAMAGE AND ELECTRICAL INVESTIGATION SO SCANNING LA English DT Article ID RAMAN-SCATTERING AB The residual damage incurred by various SiCl4 reactive ion etching (RIE) conditions was investigated by transmission electron microscopy (TEM), Raman spectroscopy, ion channeling, and electrical characterization methods. Lattice damage to depths greater than 100 nm was incurred in all of the RIE processing situations. The lowest power density, longest etch time RIE exhibited the lowest defect density, roughest surface morphology, and poorest quality GaAs regrowth. The highest power density, shortest etch time RIE displayed the highest defect density, smoothest surface morphology, and highest quality GaAs regrowth. The electrical measurements, Schottky diode characteristics, degraded with decreasing power density and increasing etch times. Overall, the characterization results suggest that the high power density, shortest etch time sample possesses the most desirable properties for device fabrication requirements. C1 VARIAN RES CTR,PALO ALTO,CA. RP COLE, MW (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. NR 8 TC 3 Z9 3 U1 0 U2 0 PU FAMS INC PI MAHWAH PA BOX 832, MAHWAH, NJ 07430 SN 0161-0457 J9 SCANNING JI Scanning PD JAN-FEB PY 1992 VL 14 IS 1 BP 31 EP 36 PG 6 WC Instruments & Instrumentation; Microscopy SC Instruments & Instrumentation; Microscopy GA HC517 UT WOS:A1992HC51700005 ER PT J AU HOLSENBECK, LS DAVIDSON, LM HOSTETTER, RE CASANOVA, MF TAYLOR, DO KELLEY, CT PERROTTA, C BORISON, RL DIAMOND, B AF HOLSENBECK, LS DAVIDSON, LM HOSTETTER, RE CASANOVA, MF TAYLOR, DO KELLEY, CT PERROTTA, C BORISON, RL DIAMOND, B TI VENTRICLE-TO-BRAIN RATIO AND SYMPTOMS AT THE ONSET OF 1ST-BREAK SCHIZOPHRENIA SO SCHIZOPHRENIA BULLETIN LA English DT Article ID COMPUTERIZED-TOMOGRAPHY; NEGATIVE SYMPTOMS; ENLARGEMENT; DISORDER; SIZE; ABNORMALITIES; CHOICE; SCANS; DEFINITION AB Ventricle-to-brain ratio (VBR) was measured from the computed tomographic (CT) scans of 33 very recent-onset psychotic patients. Illness severity and positive and negative symptoms were also assessed in 21 of these patients with schizophreniform disorder. Forty-five neurology patients served as controls. Analyses revealed no significant differences between the VBR of the psychotic group as a whole, the schizophreniform subgroup, the affective psychotic subgroup, and the controls. Control subjects with a neurological diagnosis of vertigo or syncope had significantly higher VBR than the remainder of the control group and the psychotic group. When the psychotic group was compared to the control group minus those controls with syncope or vertigo, the psychotic group had significantly higher VBR. The schizophreniform subgroup also had significantly higher VBR than the control group minus subjects with vertigo or syncope. In the schizophreniform subgroup, positive symptoms and illness severity were associated with smaller VBR. There was no association between negative symptoms and VBR. C1 DWIGHT D EISENHOWER ARMY MED CTR,DEPT PSYCHIAT & NEUROL,FT GORDON,GA 30905. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. MED COLL GEORGIA,DEPT PSYCHIAT & HLTH BEHAV,AUGUSTA,GA 30912. VET AFFAIRS MED CTR,AUGUSTA,GA. NR 47 TC 4 Z9 4 U1 1 U2 1 PU US GOVERNMENT PRINTING OFFICE PI WASHINGTON PA SUPT OF DOCUMENTS, WASHINGTON, DC 20402-9325 SN 0586-7614 J9 SCHIZOPHRENIA BULL JI Schizophr. Bull. PY 1992 VL 18 IS 3 BP 427 EP 435 PG 9 WC Psychiatry SC Psychiatry GA JL328 UT WOS:A1992JL32800006 PM 1411330 ER PT J AU KRISHNAMURTI, C ALVING, BM AF KRISHNAMURTI, C ALVING, BM TI PLASMINOGEN-ACTIVATOR INHIBITOR TYPE-1 - BIOCHEMISTRY AND EVIDENCE FOR MODULATION OF FIBRINOLYSIS INVIVO SO SEMINARS IN THROMBOSIS AND HEMOSTASIS LA English DT Article ID FAST-ACTING INHIBITOR; HUMAN-ENDOTHELIAL CELLS; DEEP-VEIN THROMBOSIS; DEXAMETHASONE-INDUCED INHIBITOR; CORONARY-ARTERY DISEASE; MESSENGER-RNA LEVELS; TISSUE-TYPE; PROTEIN-C; HUMAN-PLASMA; VENOUS THROMBOSIS RP KRISHNAMURTI, C (reprint author), WALTER REED ARMY MED CTR,DIV MED,HEMATOL BRANCH,WASHINGTON,DC 20307, USA. NR 158 TC 64 Z9 66 U1 0 U2 0 PU THIEME MEDICAL PUBL INC PI NEW YORK PA 381 PARK AVE SOUTH, NEW YORK, NY 10016 SN 0094-6176 J9 SEMIN THROMB HEMOST JI Semin. Thromb. Hemost. PD JAN PY 1992 VL 18 IS 1 BP 67 EP 80 DI 10.1055/s-2007-1002412 PG 14 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA HH790 UT WOS:A1992HH79000010 PM 1374195 ER PT J AU DAIL, PW KOSHES, RJ AF DAIL, PW KOSHES, RJ TI TREATMENT ISSUES AND TREATMENT CONFIGURATIONS FOR MENTALLY-ILL HOMELESS WOMEN SO SOCIAL WORK IN HEALTH CARE LA English DT Article ID POLICY AB This article reviews and discusses various issues pertinent to effective delivery of treatment services to mentally ill homeless women. The central emphasis is upon the gender-specific issues unique to this population and includes attention to distinctive features of effective case management, utilization of group therapy techniques, and greater integration of the psychiatrist into the treatment team. The article concludes with a discussion of the future issues relevant to community based services to homeless mentally ill women. C1 KENNER ARMY COMMUNITY HOSP,FT LEE,VA 23801. RP DAIL, PW (reprint author), IOWA STATE UNIV SCI & TECHNOL,DEPT HUMAN DEV & FAMILY STUDIES,214 ANDREWS HOUSE,AMES,IA 50011, USA. NR 58 TC 6 Z9 6 U1 0 U2 1 PU HAWORTH PRESS INC PI BINGHAMTON PA 10 ALICE ST, BINGHAMTON, NY 13904-1580 SN 0098-1389 J9 SOC WORK HEALTH CARE JI Soc. Work Health Care PY 1992 VL 17 IS 4 BP 27 EP 44 DI 10.1300/J010v17n04_02 PG 18 WC Social Work SC Social Work GA KD165 UT WOS:A1992KD16500002 PM 1465720 ER PT J AU MCKEEHAN, I CAMPBELL, RE AF MCKEEHAN, I CAMPBELL, RE TI THE INTERNATIONAL CONFLICTS IN SOVIET ARMY SO SOTSIOLOGICHESKIE ISSLEDOVANIYA LA Russian DT Article C1 US MIL ACAD,W POINT,NY 10996. RP MCKEEHAN, I (reprint author), COLUMBIA UNIV,HARRIMAN INST USSR STUDIES,NEW YORK,NY 10027, USA. NR 27 TC 0 Z9 0 U1 0 U2 0 PU MEZHDUNARODNAYA KNIGA PI MOSCOW PA 39 DIMITROVA UL., 113095 MOSCOW, RUSSIA SN 0132-1625 J9 SOTSIOL ISSLED+ JI Sotsiologicheskie Issled. PY 1992 IS 1 BP 94 EP 104 PG 11 WC Sociology SC Sociology GA JN693 UT WOS:A1992JN69300010 ER PT J AU BLANK, S AF BLANK, S TI THE GREAT CHALLENGE - NATIONALITIES AND THE BOLSHEVIK STATE 1917-1930 - DENCAUSSE,HC SO SOVIET STUDIES LA English DT Book Review RP BLANK, S (reprint author), USA,COLL WAR,CARLISLE BARRACKS,PA, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU CARFAX PUBL CO PI ABINGDON PA PO BOX 25, ABINGDON, OXFORDSHIRE, ENGLAND OX14 3UE SN 0038-5859 J9 SOV STUD PY 1992 VL 44 IS 6 BP 1106 EP 1107 PG 2 WC Area Studies; Economics SC Area Studies; Business & Economics GA JY862 UT WOS:A1992JY86200016 ER PT J AU MICKEVICIUS, R MITIN, VV KIM, KW STROSCIO, MA AF MICKEVICIUS, R MITIN, VV KIM, KW STROSCIO, MA TI ELECTRON INTERSUBBAND SCATTERING IN REAL QUANTUM WIRES SO SUPERLATTICES AND MICROSTRUCTURES LA English DT Article ID PHONONS C1 N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695. USA,RES OFF,RES TRIANGLE PK,NC 27709. RP MICKEVICIUS, R (reprint author), WAYNE STATE UNIV,DEPT ELECT & COMP ENGN,DETROIT,MI 48202, USA. NR 9 TC 6 Z9 6 U1 1 U2 1 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0749-6036 J9 SUPERLATTICE MICROST JI Superlattices Microstruct. PY 1992 VL 11 IS 3 BP 277 EP 280 DI 10.1016/0749-6036(92)90380-N PG 4 WC Physics, Condensed Matter SC Physics GA HN107 UT WOS:A1992HN10700007 ER PT J AU MOZINGO, DW WALTERS, MJ OTCHY, DP ROSENTHAL, D AF MOZINGO, DW WALTERS, MJ OTCHY, DP ROSENTHAL, D TI PROPERITONEAL SYNTHETIC MESH REPAIR OF RECURRENT INGUINAL-HERNIAS SO SURGERY GYNECOLOGY & OBSTETRICS LA English DT Article ID HERNIOPLASTY; GROIN AB Safe reconstruction of the inguinal floor is the goal of any operation for repair of groin herniation. Operating in the properitoneal space avoids dissection of the scarred cord, and the incidence of testicular complications is markedly lowered. This study reports our experience with placing synthetic mesh between the peritoneum and the deficient inguinal floor for the repair of recurrent hernias of the groin area. During a five year period, 84 men underwent repair of 100 recurrent inguinal hernias using the properitoneal approach. Fifty-four patients had repair of a unilateral recurrent hernia, 16 had repair of a bilateral recurrent hernia and 14 had repair of both a recurrent hernia and a contralateral primary hernia. Postoperative complications occurred in six patients. No testicular complications were observed. Postoperative follow-up study ranged from six months to five years. There were only three recurrent hernias aft this repair All occurred within the first six months postoperatively. The properitoneal approach for repair of recurrent groin hernias using prosthetic mesh safely creates a new "fascia transversalis" with a low rate Of recurrence and effectively eliminates testicular complications. C1 BROOKE ARMY MED CTR,DEPT SURG,DIV GEN SURG,FT SAM HOUSTON,TX 78234. NR 21 TC 12 Z9 12 U1 0 U2 0 PU FRANKLIN H MARTIN FOUNDATION PI CHICAGO PA 55 E ERIE ST, CHICAGO, IL 60611 SN 0039-6087 J9 SURG GYNECOL OBSTET JI Surg. Gynecol. Obstet. PD JAN PY 1992 VL 174 IS 1 BP 33 EP 35 PG 3 WC Obstetrics & Gynecology; Surgery SC Obstetrics & Gynecology; Surgery GA GY399 UT WOS:A1992GY39900007 PM 1729746 ER PT J AU CHIRIGOS, MA AF CHIRIGOS, MA TI IMMUNOMODULATORS - CURRENT AND FUTURE-DEVELOPMENT AND APPLICATION SO THYMUS LA English DT Review DE IMMUNOMODULATORS; CYTOKINES ID BACILLUS CALMETTE-GUERIN; SUPERFICIAL BLADDER-TUMORS; ACTIVATED KILLER CELLS; DEXTRAN SULFATE; ADJUVANT THERAPY; CANCER; INTERLEUKIN-2; LEVAMISOLE; CARCINOMA; AIDS RP CHIRIGOS, MA (reprint author), USA,MED RES INST INFECT DIS,FT DETRICK,FREDERICK,MD 21702, USA. NR 43 TC 11 Z9 11 U1 0 U2 0 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0165-6090 J9 THYMUS JI Thymus PY 1992 VL 19 SU 1 BP S7 EP S20 PG 14 WC Immunology SC Immunology GA HP724 UT WOS:A1992HP72400002 PM 1585422 ER PT J AU HENDERSON, JD HIGGINS, RJ DACRE, JC WILSON, BW AF HENDERSON, JD HIGGINS, RJ DACRE, JC WILSON, BW TI NEUROTOXICITY OF ACUTE AND REPEATED TREATMENTS OF TABUN, PARAOXON, DIISOPROPYL FLUOROPHOSPHATE AND ISOFENPHOS TO THE HEN SO TOXICOLOGY LA English DT Article DE NEUROTOXICITY; ORGANOPHOSPHATES; HEN; TABUN; PARAOXON; DIISOPROPYL FLUOROPHOSPHATE; ISOFENPHOS ID ORGANO-PHOSPHORUS ESTERS; DELAYED NEUROTOXICITY; TOXICITY; ORGANOPHOSPHATES; POLYNEUROPATHY; NEUROPATHY; CHICKEN; ASSAY; BRAIN; SOMAN AB The neuropathic potential of acute and repeated exposures of the phosphoramidates tabun (GA) and isofenphos (IFP), of diisopropyl fluorophosphate (DFP) and paraoxon (PO) were examined in the hen with treatments for up to 90 days via intramuscular injections of the highest tolerated doses with atropine protection. Plasma acetylcholinesterase (AChE), non-specific butyrylcholinesterase (BChE) and creatine kinase (CK) activities were measured in order to monitor whether the compounds were present at biologically active concentrations. Locomotor behavior was observed and tissues from the peripheral and central nervous systems were examined for signs of organophosphate-induced delayed neuropathy (OPIDN). No behavioral or histological evidence of OPIDN was observed after treatments with GA, IFP, PO, saline or atropine sulfate. DFP-treated birds displayed locomotor and neuropathological signs of OPIDN with a no effect level (NOEL) between 25 and 50-mu-g/kg. C1 UNIV CALIF DAVIS,DEPT AVIAN SCI,DAVIS,CA 95616. UNIV CALIF DAVIS,SCH VET MED,DEPT PATHOL,DAVIS,CA 95616. UNIV CALIF DAVIS,INST TOXICOL & ENVIRONM HLTH,DAVIS,CA 95616. USA,BIOMED RES & DEV LAB,FREDERICK,MD 21702. FU NIEHS NIH HHS [ES 00202] NR 28 TC 14 Z9 14 U1 0 U2 0 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0300-483X J9 TOXICOLOGY JI Toxicology PY 1992 VL 72 IS 2 BP 117 EP 129 DI 10.1016/0300-483X(92)90106-O PG 13 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA HP300 UT WOS:A1992HP30000001 PM 1566275 ER PT B AU KENDE, M AF KENDE, M BE WILLIAMS, JC KOCAN, KM GIBBS, EPJ TI TREATMENT STRATEGIES FOR HUMAN ARBOVIRAL INFECTIONS APPLICABLE TO VETERINARY-MEDICINE SO TROPICAL VETERINARY MEDICINE : CURRENT ISSUES PERSPECTIVES SE ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Proceedings Paper CT 1ST BIENNIAL CONF OF THE AMERICAN SOC OF TROPICAL VETERINARY MEDICINE CY FEB 05-08, 1991 CL SAN JUAN, PR SP AMER SOC TROP VET MED, ADV INSTRUMENTS, CARIBBEAN BIORES, MAYAGUEZ DAIRY, MERCK SHARP & DOHME, NICOLAS CARRILLO CORREA, PITMAN MOORE, RHONE MERIEUX LAB, SCHERING PLOUGH ANIM HLTH, UPJOHN RP KENDE, M (reprint author), USA,MED RES INST INFECT DIS,DEPT CLIN IMMUNOL,DIV MED,FT DETRICK,FREDERICK,MD 21701, USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA NEW YORK BN 0-89766-728-X J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PY 1992 VL 653 BP 297 EP 313 DI 10.1111/j.1749-6632.1992.tb19657.x PG 17 WC Parasitology; Veterinary Sciences SC Parasitology; Veterinary Sciences GA BW42Y UT WOS:A1992BW42Y00036 PM 1626881 ER PT J AU HEBDEN, RA FREUND, BJ CLAYBAUGH, JR ICHIMURA, WM HASHIRO, GM AF HEBDEN, RA FREUND, BJ CLAYBAUGH, JR ICHIMURA, WM HASHIRO, GM TI EFFECT OF INSPIRATORY-PHASE NEGATIVE-PRESSURE BREATHING ON URINE FLOW IN MAN SO UNDERSEA BIOMEDICAL RESEARCH LA English DT Article ID SATURATION DIVE; RECEPTORS; RESPONSES; SALT AB We investigated the effect of negative pressure breathing during the inspiratory phase only (intermittent NPB) in 9 healthy male subjects who were in a sitting position and had no food or fluid intake for 12 h before the study. Intermittent NPB was without effect on urine flow and urinary sodium excretion but caused a significant increase in creatinine clearance. Plasma renin activity was significantly reduced, whereas plasma antidiuretic hormone (ADH), atrial natriuretic factor (ANF), and aldosterone levels were unaffected. To determine whether the blunted urinary response to intermittent NPB was a postural phenomenon, the study was repeated in 6 of the subjects while supine. Under these conditions there was a significant increase in urine flow and plasma ANF levels, but no change in all other measured variables. These results are consistent with a role for ANF, but not ADH, in the diuresis seen in supine subjects during NPB. C1 TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96859. FU NHLBI NIH HHS [HL-28542] NR 18 TC 5 Z9 5 U1 0 U2 0 PU UNDERSEA & HYPERBARIC MEDICAL SOC INC PI KENSINGTON PA 10531 METROPOLITAN AVE, KENSINGTON, MD 20895 SN 0093-5387 J9 UNDERSEA BIOMED RES PD JAN PY 1992 VL 19 IS 1 BP 21 EP 29 PG 9 WC Oceanography SC Oceanography GA HE892 UT WOS:A1992HE89200004 PM 1531561 ER PT J AU SCHMALJOHN, CS HASTY, SE DALRYMPLE, JM AF SCHMALJOHN, CS HASTY, SE DALRYMPLE, JM TI PREPARATION OF CANDIDATE VACCINIA-VECTORED VACCINES FOR HEMORRHAGIC-FEVER WITH RENAL SYNDROME SO VACCINE LA English DT Article DE VACCINIA; BUNYAVIRIDAE; HEMORRHAGIC FEVER WITH RENAL SYNDROME; HANTAAN VIRUS ID HANTAAN VIRUS; GENOME SEGMENT; NUCLEOTIDE-SEQUENCE; CODING STRATEGY; RECOMBINANT; BACULOVIRUS; EXPRESSION; PLAQUES AB Two vaccinia-vectored candidate vaccines for haemorrhagic fever with renal syndrome were prepared by inserting cDNA, representing the medium (M) genome segment, or the M and the small (S) genome segments of Hantaan virus into the thymidine kinase gene of the Connaught vaccine strain of vaccinia virus. In the single recombinant, the M segment was placed under control of the vaccinia virus 7.5 kDa promoter. In the double recombinant, the M and S segments were placed under control of the vaccinia virus 7.5 kDa and 11 kDa, promoters, respectively. An immunoplaque assay technique was developed to select recombinants without the need for expression of irrelevant genes or use of potential mutagens. Proteins indistinguishable from authentic viral envelope glycoproteins and nucleocapsid protein were observed by immunoprecipitation with antibodies to Hantaan virus. The recombinant expressing both the M and the S segments was selected for further development and testing as a human vaccine. RP SCHMALJOHN, CS (reprint author), USA,MED RES INST INFECT DIS,DIV VIROL,FREDERICK,MD 21702, USA. NR 9 TC 39 Z9 41 U1 0 U2 0 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PY 1992 VL 10 IS 1 BP 10 EP 13 DI 10.1016/0264-410X(92)90412-D PG 4 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA HL742 UT WOS:A1992HL74200003 PM 1347189 ER PT J AU BRYAN, JP SJOGREN, MH MACARTHY, P COX, E LEGTERS, LJ PERINE, PL AF BRYAN, JP SJOGREN, MH MACARTHY, P COX, E LEGTERS, LJ PERINE, PL TI PERSISTENCE OF ANTIBODY TO HEPATITIS-B SURFACE-ANTIGEN AFTER LOW-DOSE, INTRADERMAL HEPATITIS-B IMMUNIZATION AND RESPONSE TO A BOOSTER DOSE SO VACCINE LA English DT Article DE HEPATITIS-B VACCINE; LOW-DOSE; INTRADERMAL; BOOSTER; ANTIBODY ID MENTALLY-RETARDED PATIENTS; IMMUNE-RESPONSE; VACCINATION; IMMUNOGENICITY; EFFICACY; STUDENTS; DURATION; VACCINES AB To determine the duration of antibody after low-dose, intradermal (i.d.), plasma-derived hepatitis B vaccination and the response to a booster dose, we studied two classes of medical students who were immunized with 2-mu-g doses i.d. In one class, 73/88 (85%) who had been immunized by skilled personnel at 0, 1 and 6 months, had protective concentrations (greater-than-or-equal-to 10 mIU ml-1) of anti-HBs at 20 months after the first dose. Twelve (92%) out of 13 students who received only two doses at 0 and 1 months also had protective concentrations at month 20. At month 27, 11/16 (69%) with antibody less-than-or-equal-to 10 mIU ml-1 responded to a fourth dose of 2-mu-g i.d. with protective concentrations of anti-HBs. In the second class, after three doses of vaccine at 0, 1, and 6 months, protective concentrations of anti-HBs were present in 90/93 (97%) at 14 months and in 71/80 (89%) at 25 months. In those who received only two doses, protective concentrations were found in 24/31 (74%) at 14 months and 9/16 (56%) at 25 months. After a booster dose of 2-mu-g i.d. at month 25, anti-HBs concentrations rose from a geometric mean of 78 to 1198 mIU ml-1 in 60 subjects previously immunized with three doses and from 18 to 1054 mIU ml-1 in 16 students previously immunized with only two doses. Overall, 73/76 (96%) of students in the second group had protective concentrations of antibody after the booster dose. Anti-HBs remains above protective concentrations after low-dose, i.d., plasma-derived hepatitis B vaccination in 85-89% of young adults when measured at 2 years after initial immunization. An i.d. booster dose at 2 years resulted in a sharp increase in anti-HBs regardless of whether the students had received two or three doses during initial immunization. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP BRYAN, JP (reprint author), UNIFORMED SERV UNIV HLTH SCI,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. NR 38 TC 9 Z9 11 U1 0 U2 0 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PY 1992 VL 10 IS 1 BP 33 EP 38 DI 10.1016/0264-410X(92)90416-H PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA HL742 UT WOS:A1992HL74200007 PM 1531719 ER PT J AU MALINOSKI, FJ AF MALINOSKI, FJ TI STRENUOUS EXERCISE SIMULATING HEPATIC-INJURY DURING VACCINE TRIALS SO VACCINE LA English DT Article DE EXERCISE; CREATINE PHOSPHOKINASE; HEPATIC INJURY; VACCINE TRIALS; TRANSAMINASE ID MUSCLE; PLASMA; MEN AB Three healthy young men participating in phase 1 clinical vaccine trials had unexplained increases in their serum transaminase levels. Retrospective analysis indicated that these volunteers had participated in strenuous physical training 2-5 days prior to the noted elevations. The pattern of serum enzyme elevations, initially thought to be consistent with hepatic injury, were associated with parallel increases in creatine phosphokinase. One individual consented to repeat his exercise regimen. This was followed by a recurrence of the same pattern of increases in serum enzymes, including creatine phosphokinase. Thus, in trials where serum enzymes will be measured, it may be prudent to encourage subjects to refrain from increasing their activity above that which they normally perform. RP MALINOSKI, FJ (reprint author), USA,MED RES INST INFECT DIS,DIV VIROL,FREDERICK,MD 21702, USA. NR 11 TC 8 Z9 10 U1 0 U2 2 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PY 1992 VL 10 IS 1 BP 39 EP 42 DI 10.1016/0264-410X(92)90417-I PG 4 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA HL742 UT WOS:A1992HL74200008 PM 1539458 ER PT J AU NEWLAND, JW HALE, TL FORMAL, SB AF NEWLAND, JW HALE, TL FORMAL, SB TI GENOTYPIC AND PHENOTYPIC CHARACTERIZATION OF AN AROD DELETION-ATTENUATED ESCHERICHIA-COLI K12-SHIGELLA-FLEXNERI HYBRID VACCINE EXPRESSING SHIGELLA-FLEXNERI 2A-SOMATIC ANTIGEN SO VACCINE LA English DT Article DE ESCHERICHIA-COLI-SHIGELLA HYBRID VACCINE; AROD DELETION; ATTENUATION ID SHIGELLA-FLEXNERI; POLYACRYLAMIDE GELS; PLASMID; PROTEIN; IDENTIFICATION; SEQUENCE; MONKEYS; SPREAD; LOCUS; K-12 AB The construction and characterization of EcSf2a-2, an aroD-deleted Escherichia coli-Shigella hybrid vaccine carrying chromosomal and plasmid genes from Shigella flexneri and expressing S. flexneri 2a somatic antigen in association with E. coli K12 core are described. Expression of hybrid lipopolysaccharide and deletion of aroD resulted in the attenuation of phenotypic characteristics associated with pathogenicity. The addition of an aroD deletion results in a requirement for an aromatic precursor of para-aminobenzoic acid (PABA), an essential bacterial metabolite not present in mammalian tissues. The biosynthesis of hybrid somatic antigen prevents expression of a Sereny-positive reaction by invasive bacteria capable of expressing a plaque-positive phenotype. A functional kcpA gene is required for expression of the plaque-positive phenotype. The presence of an aroD deletion does not interfere with expression of an invasive phenotype; however, in bacteria containing afunctional kcpA gene, replication and spread by invading bacteria are limited, preventing development of the plaque-positive phenotype. RP NEWLAND, JW (reprint author), WALTER REED ARMY MED CTR,DEPT ENTER INFECT,WASHINGTON,DC 20307, USA. NR 31 TC 23 Z9 23 U1 0 U2 0 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PY 1992 VL 10 IS 11 BP 766 EP 776 DI 10.1016/0264-410X(92)90512-I PG 11 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA JK111 UT WOS:A1992JK11100009 PM 1441732 ER PT J AU HERRINGTON, DA LOSONSKY, GA SMITH, G VOLVOVITZ, F COCHRAN, M JACKSON, K HOFFMAN, SL GORDON, DM LEVINE, MM EDELMAN, R AF HERRINGTON, DA LOSONSKY, GA SMITH, G VOLVOVITZ, F COCHRAN, M JACKSON, K HOFFMAN, SL GORDON, DM LEVINE, MM EDELMAN, R TI SAFETY AND IMMUNOGENICITY IN VOLUNTEERS OF A RECOMBINANT PLASMODIUM-FALCIPARUM CIRCUMSPOROZOITE PROTEIN MALARIA VACCINE PRODUCED IN LEPIDOPTERAN CELLS SO VACCINE LA English DT Article DE PLASMODIUM-FALCIPARUM MALARIA VACCINE; RECOMBINANT VACCINE; SPOROZOITE ID VIVAX SPOROZOITE VACCINE; CD8+ T-CELLS; EPITOPE; PROTECTION; IMMUNITY; PARASITE; MAP AB A recombinant Plasmodium falciparum circumsporozoite (CS) antigen (rPfCSA) was produced in insect cells using a baculovirus expression vector containing the entire CS gene. This near full-length CS antigen was adsorbed onto aluminium phosphate for use as a malaria vaccine. In a study of safety and immunogenicity, 20 volunteers were divided into four groups of five each and inoculated intramuscularly with 10, 100, 500 or 1000-mu-g of vaccine. Primary vaccinations were followed by two booster immunizations at 2 and 6 months. Three volunteers developed prominent local reactions manifested as tenderness, redness and swelling at the injection site following the second or third vaccination. All symptoms resolved spontaneously within 72 h. Postimmunization sera from six of 20 volunteers showed seroconversions as measured by Western blot, using rPfCSA as antigen. However, specific anti-CS protein antibody could not be detected by indirect immunoflourescence against intact sporozoites or by ELISA using rPfCSA or peptide to the repeat region. In addition, 18 of 20 volunteers developed antibody to baculovirus proteins as determined by ELISA and/or Western blot. Antigen-driven replication studies using peripheral blood mononuclear cells from vaccinees failed to detect proliferative responses specific to CS protein. This recombinant CS protein vaccine, as formulated, was minimally immunogenic in humans. C1 UNIV MARYLAND,DEPT MED,DIV GEOG MED,CTR VACCINE DEV,BALTIMORE,MD 21201. USN,MED RES INST,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. MICROGENESYS INC,MERIDEN,CT 06450. FU NIAID NIH HHS [N01-AI-62528] NR 24 TC 26 Z9 28 U1 0 U2 0 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PY 1992 VL 10 IS 12 BP 841 EP 846 DI 10.1016/0264-410X(92)90047-N PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA JN775 UT WOS:A1992JN77500007 PM 1455910 ER PT J AU BINN, LN MACARTHY, PO MARCHWICKI, RH SJOGREN, MH HOKE, CH BURGE, JR DHONDT, E AF BINN, LN MACARTHY, PO MARCHWICKI, RH SJOGREN, MH HOKE, CH BURGE, JR DHONDT, E TI LABORATORY TESTS AND REFERENCE REAGENTS EMPLOYED IN STUDIES OF INACTIVATED HEPATITIS-A VACCINE SO VACCINE LA English DT Article; Proceedings Paper CT INTERNATIONAL SYMP ON ACTIVE IMMUNIZATION AGAINST HEPATITIS-A CY JAN 27-29, 1992 CL VIENNA, AUSTRIA DE HEPATITIS-A; IMMUNOASSAY; NEUTRALIZATION TEST ID CELL-CULTURES; VIRUS; ANTIBODY AB Procedures to evaluate inactivated hepatitis A vaccines in volunteers have been examined. Solid-phase immunoassays were standardized with reference preparations and have been tested to measure antibody response to immunization and antigen content of vaccines. Following immunization, there was a good correlation between antibody response, determined with commercial immunoassays, and neutralization titres, as measured by the radioimmunofocus inhibition test. However, at lower titres of neutralizing antibody, the commercial immunoassay often yielded negative results. To improve the sensitivity of the immunoassay, the serum volume was increased. A fourfold increase of test serum resulted in greater sensitivity, increasing from 54 to 94%, while retaining 100% specificity. Further increases in the volume of test serum resulted in a loss of specificity. In a comparison of neutralization tests, similar titres of postvaccination sera were obtained by using the HM175/18f cytopathic strain of hepatitis A virus in a plaque reduction assay or the HM175 parental virus in the radioimmunofocus inhibition test. Use of the cytopathic virus obviates the need for radioactively labelled serum and reduces the time taken to conduct neutralization tests. The current laboratory procedures can meet the needs of large field trials of inactivated hepatitis A vaccines. C1 SMITHKLINE BEECHAM BIOL,RIXENSART,BELGIUM. WALTER REED ARMY INST RES,DIV BIOMETR,WASHINGTON,DC 20307. RP BINN, LN (reprint author), WALTER REED ARMY INST RES,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307, USA. NR 13 TC 12 Z9 12 U1 0 U2 0 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PY 1992 VL 10 SU 1 BP S102 EP S105 DI 10.1016/0264-410X(92)90558-2 PG 4 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA JY978 UT WOS:A1992JY97800030 PM 1335636 ER PT J AU EYCKMANS, L STEFFEN, R MAUER, W NORDENFELDT, E INVAR, R JUST, M HOKE, C HOLLINGER, B HESLA, P NOAH, N VODOPIJA, I NISHIOKA, K MARGOLIS, H MEISTER, W VANDOORSLAER, E DESMYTER, J DESMYTER, J KANE, M AF EYCKMANS, L STEFFEN, R MAUER, W NORDENFELDT, E INVAR, R JUST, M HOKE, C HOLLINGER, B HESLA, P NOAH, N VODOPIJA, I NISHIOKA, K MARGOLIS, H MEISTER, W VANDOORSLAER, E DESMYTER, J DESMYTER, J KANE, M TI EPIDEMIOLOGY OF HEPATITIS-A - DISCUSSION SO VACCINE LA English DT Discussion C1 UNIV ZURICH,INST SOCIAL & PREVENT MED,DIV EPIDEMIOL & PREVENT COMMUNICABLE DIS,CH-8006 ZURICH,SWITZERLAND. UNIV LUND,DEPT MED MICROBIOL,S-22362 LUND,SWEDEN. WALTER REED ARMY INST RES,DEPT VIRUS DIS,WASHINGTON,DC 20307. BAYLOR COLL MED,HOUSTON,TX 77030. NORWEGIAN ARMED FORCES,LAND DEF DIST 4,N-2056 ALGARHEIM,NORWAY. ERASMUS UNIV,INST MED TECHNOL ASSESSMENT,3000 DR ROTTERDAM,NETHERLANDS. WHO,DIV COMMUNICABLE DIS,MICROBIOL & IMMUNOL SUPPORT SERV,CH-1211 GENEVA 27,SWITZERLAND. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PY 1992 VL 10 SU 1 BP S97 EP S98 PG 2 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA JY978 UT WOS:A1992JY97800028 ER PT J AU HOKE, CH BINN, LN EGAN, JE DEFRAITES, RF MACARTHY, PO INNIS, BL ECKELS, KH DUBOIS, D DHONDT, E SJOGREN, MH RICE, R SADOFF, JC BANCROFT, WH AF HOKE, CH BINN, LN EGAN, JE DEFRAITES, RF MACARTHY, PO INNIS, BL ECKELS, KH DUBOIS, D DHONDT, E SJOGREN, MH RICE, R SADOFF, JC BANCROFT, WH TI HEPATITIS-A IN THE UNITED-STATES-ARMY - EPIDEMIOLOGY AND VACCINE DEVELOPMENT SO VACCINE LA English DT Article; Proceedings Paper CT INTERNATIONAL SYMP ON ACTIVE IMMUNIZATION AGAINST HEPATITIS-A CY JAN 27-29, 1992 CL VIENNA, AUSTRIA DE MILITARY; SANITATION; INFECTIOUS HEPATITIS; PREVENTION; JAUNDICE; INACTIVATED VACCINE ID VIRUS AB Control of hepatitis A has been an important concern for US military forces in war and peace. Immune serum globulin, although effective, is exceedingly cumbersome to use. The prevalence of antibody against hepatitis A is decreasing in young American soldiers, putting them at risk of hepatitis A during deployment. The US Army has been an active participant in development of hepatitis A vaccine. The first successful cell-culture-derived, formalin-inactivated hepatitis A vaccine was developed at the Walter Reed Army Institute of Research. This prototype vaccine was shown, in 1986, to be safe and immunogenic for humans. Since then we have evaluated the following issues related to the use of inactivated hepatitis A vaccines in military populations. Immunogenicity of vaccine derived from the CLF and HM175 strains; immunogenicity of hepatitis A vaccine given by jet injector; immunogenicity of hepatitis A vaccine when given with hepatitis B vaccine; immunogenicity when given in shortened schedules; safety and immunogenicity in Thai children; and efficacy under field conditions in the tropics. The hepatitis A vaccines which we tested are safe and highly immunogenic. Immunization by jet gun confers immunity equivalent to immunization by needle. Hepatitis A vaccine is equally potent when given with hepatitis B vaccine. Data on rapid immunization schedules and efficacy are under evaluation. We conclude that hepatitis A vaccine is a major improvement in our ability to prevent hepatitis A in soldiers. C1 WALTER REED ARMY INST RES,DEPT BIOL RES,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. ARMED FORCES RES INST MED SCI,DEPT VIROL,BANGKOK,THAILAND. SMITHKLINE BEECHAM BIOL,RIXENSART,BELGIUM. RP HOKE, CH (reprint author), WALTER REED ARMY INST RES,DEPT VIRUS DIS,WASHINGTON,DC 20307, USA. NR 23 TC 24 Z9 24 U1 1 U2 1 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PY 1992 VL 10 SU 1 BP S75 EP S79 DI 10.1016/0264-410X(92)90550-4 PG 5 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA JY978 UT WOS:A1992JY97800022 PM 1335665 ER PT J AU MELNICK, J SJOGREN, M GRACHEV, V LEMON, S DHONDT, E NISHIOKA, K WIEDERMANN, G LOLEKHA, S ANDRE, F BOUGHTON, C LEENTVAARKUIJPERS, A HATZ, C AMBROSCH, F NISHIOKA, K SHOUVAL, D MELNICK, J DESMYTER, J KRUGMAN, S AF MELNICK, J SJOGREN, M GRACHEV, V LEMON, S DHONDT, E NISHIOKA, K WIEDERMANN, G LOLEKHA, S ANDRE, F BOUGHTON, C LEENTVAARKUIJPERS, A HATZ, C AMBROSCH, F NISHIOKA, K SHOUVAL, D MELNICK, J DESMYTER, J KRUGMAN, S TI HEPATITIS-A VACCINE - DEVELOPMENT, SAFETY AND IMMUNOGENICITY - DISCUSSION SO VACCINE LA English DT Discussion C1 WALTER REED ARMY INST RES,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,DIV BIOMETR,WASHINGTON,DC 20307. SMITHKLINE BEECHAM BIOL,RIXENSART,BELGIUM. UNIV VIENNA,INST SPECIF PROPHYLAXIS & TROP MENT,A-1095 VIENNA,AUSTRIA. UNIV VIENNA,INST VIROL,A-1095 VIENNA,AUSTRIA. NYU MED CTR,NEW YORK,NY 10016. REGA INST,DEPT MICROBIOL,B-3000 LOUVAIN,BELGIUM. UNIV HOSP LEUVEN,B-3000 LOUVAIN,BELGIUM. RI Grachev, Viktor/E-3539-2014 NR 0 TC 0 Z9 0 U1 0 U2 1 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PY 1992 VL 10 SU 1 BP S146 EP S147 PG 2 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA JY978 UT WOS:A1992JY97800043 ER PT J AU PURCELL, RH DHONDT, E BRADBURY, R EMERSON, SU GOVINDARAJAN, S BINN, L AF PURCELL, RH DHONDT, E BRADBURY, R EMERSON, SU GOVINDARAJAN, S BINN, L TI INACTIVATED HEPATITIS-A VACCINE - ACTIVE AND PASSIVE IMMUNOPROPHYLAXIS IN CHIMPANZEES SO VACCINE LA English DT Article; Proceedings Paper CT INTERNATIONAL SYMP ON ACTIVE IMMUNIZATION AGAINST HEPATITIS-A CY JAN 27-29, 1992 CL VIENNA, AUSTRIA DE IMMUNOPROPHYLAXIS; HEPATITIS-A VIRUS; ANIMAL MODEL; IMMUNOGLOBULIN ID NEUTRALIZING ANTIBODY; VIRUS AB Studies of active and passive immunoprophylaxis were carried out in chimpanzees to determine whether a candidate hepatitis A virus (HAV) vaccine could stimulate antibody to HAV (anti-HAV) that was qualitatively similar to anti-HAV stimulated by natural infection. Normal immune globulin (Ig) was prepared from plasma obtained from human volunteers before and after vaccination with the HAV vaccine, and these preparations or commercially prepared Ig were administered to chimpanzees. Protective efficacy was compared to that obtained after vaccination of chimpanzees. As expected, pre-vaccination Ig did not protect chimpanzees against challenge with virulent hepatitis A. In contrast, chimpanzees were protected against hepatitis A by Ig prepared from volunteers who had received hepatitis A vaccine. The protection was qualitatively similar to that afforded by commercial normal Ig containing convalescent anti-HAV. The minimum protective dose of passively acquired anti-HAV was approximately the minimum dose detectable by serological means. This information will be useful in calculating minimum acceptable titres of anti-HAV in normal Ig. Whereas administration of Ig protected chimpanzees against hepatitis A pathology, it did not protect them from infection with HAV. Thus, these chimpanzees were protected by classical passive-active immunoprophylaxis. In contrast, chimpanzees actively immunized with HAV vaccine were apparently protected against both hepatitis A pathology and HAV infection. The mechanism of this complete protection is unknown but may simply represent the higher titre of anti-HAV in the vaccinated chimpanzees, compared to the passively protected animals. C1 SMITHKLINE BEECHAM BIOL,RIXENSART,BELGIUM. BIOQUAL INC,ROCKVILLE,MD. RANCHO LOS AMIGOS MED CTR,DOWNEY,CA 90242. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. RP PURCELL, RH (reprint author), NIAID,INFECT DIS LAB,BLDG 7,ROOM 202,BETHESDA,MD 20892, USA. NR 7 TC 32 Z9 33 U1 0 U2 2 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PY 1992 VL 10 SU 1 BP S148 EP S151 DI 10.1016/0264-410X(92)90572-2 PG 4 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA JY978 UT WOS:A1992JY97800044 PM 1335648 ER PT J AU SJOGREN, MH PURCELL, RH MCKEE, K BINN, L MACARTHY, P TICEHURST, J FEINSTONE, S CAUDILL, J SEE, A HOKE, C BANCROFT, W DHONDT, E AF SJOGREN, MH PURCELL, RH MCKEE, K BINN, L MACARTHY, P TICEHURST, J FEINSTONE, S CAUDILL, J SEE, A HOKE, C BANCROFT, W DHONDT, E TI CLINICAL AND LABORATORY OBSERVATIONS FOLLOWING ORAL OR INTRAMUSCULAR ADMINISTRATION OF A LIVE ATTENUATED HEPATITIS-A VACCINE CANDIDATE SO VACCINE LA English DT Article; Proceedings Paper CT INTERNATIONAL SYMP ON ACTIVE IMMUNIZATION AGAINST HEPATITIS-A CY JAN 27-29, 1992 CL VIENNA, AUSTRIA DE HEPATITIS-A; VIRAL HEPATITIS; LIVER ID VIRUS; ANTIBODY AB Clinical observations made after immunising volunteers with a live attenuated hepatitis A vaccine are described. The candidate vaccine was prepared with the HM175 strain of hepatitis A virus and shown to be safe, immunogenic and efficacious in experimental animals. When the candidate vaccine was tested by oral administration in humans at increasing doses - 10(4), 10(5), 10(6) and 10(7) median tissue culture infective doses ( TCID50) - an antibody response was not observed at any dose. Volunteers who received similar doses by the intramuscular route developed antibody to hepatitis A three weeks after immunization with 10(6) or 10(7) TCID50. The antibody response was sustained for the 12 weeks of the observation period. All volunteers remained healthy with normal results from liver tests throughout the monitoring period. Further clinical observations of this product are in progress. C1 NIH,BETHESDA,MD 20892. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. US FDA,ROCKVILLE,MD 20857. SMITHKLINE BEECHAM BIOL,RIXENSART,BELGIUM. RP SJOGREN, MH (reprint author), USA,MED RES INST INFECT DIS,DIV MED,FREDERICK,MD 21702, USA. RI Ticehurst, John/I-7532-2012 NR 7 TC 20 Z9 20 U1 0 U2 1 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PY 1992 VL 10 SU 1 BP S135 EP S137 DI 10.1016/0264-410X(92)90568-5 PG 3 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA JY978 UT WOS:A1992JY97800040 PM 1335645 ER PT J AU RUUSALA, A PERSSON, R SCHMALJOHN, CS PETTERSSON, RF AF RUUSALA, A PERSSON, R SCHMALJOHN, CS PETTERSSON, RF TI COEXPRESSION OF THE MEMBRANE GLYCOPROTEIN-G1 AND GLYCOPROTEIN-G2 OF HANTAAN VIRUS IS REQUIRED FOR TARGETING TO THE GOLGI-COMPLEX SO VIROLOGY LA English DT Article C1 LUDWIG INST CANC RES, STOCKHOLM BRANCH, BOX 60202, S-10401 STOCKHOLM, SWEDEN. USA, MED RES INST INFECT DIS, DIV VIROL, FREDERICK, MD 21701 USA. NR 42 TC 53 Z9 55 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0042-6822 J9 VIROLOGY JI Virology PD JAN PY 1992 VL 186 IS 1 BP 53 EP 64 DI 10.1016/0042-6822(92)90060-3 PG 12 WC Virology SC Virology GA GU994 UT WOS:A1992GU99400006 PM 1727611 ER PT B AU MALONEY, SW RAY, BT AF MALONEY, SW RAY, BT GP AMER WATER WORKS ASSOC TI THE IMPORTANCE OF GALVANIC COUPLES TO LEAD CONTROL STUDIES SO WATER QUALITY TECHNOLOGY CONFERENCE, PROCEEDINGS - AWWA 1991, PTS 1 AND 2: ADVANCES IN WATER ANALYSIS AND TREATMENT LA English DT Proceedings Paper CT Water Quality Technology Conference: Advances in Water Analysis and Treatment CY NOV 10-14, 1991 CL ORLANDO, FL SP AMER WATER WORKS ASSOC C1 USA,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER WATER WORKS ASSOC PI DENVER PA 6666 WEST QUINCY AVE, DENVER, CO 80235 BN 0-89867-618-5 PY 1992 BP 289 EP 297 PG 9 WC Biotechnology & Applied Microbiology; Chemistry, Applied; Water Resources SC Biotechnology & Applied Microbiology; Chemistry; Water Resources GA BA61B UT WOS:A1992BA61B00020 ER PT B AU SCHOLZE, RJ PONTOW, KA RAY, BT AF SCHOLZE, RJ PONTOW, KA RAY, BT GP AMER WATER WORKS ASSOC TI APPLICATION OF THE CERL PIPE LOOP SYSTEM TO EVALUATE LEAD IN DRINKING-WATER SO WATER QUALITY TECHNOLOGY CONFERENCE, PROCEEDINGS - AWWA 1991, PTS 1 AND 2: ADVANCES IN WATER ANALYSIS AND TREATMENT LA English DT Proceedings Paper CT Water Quality Technology Conference: Advances in Water Analysis and Treatment CY NOV 10-14, 1991 CL ORLANDO, FL SP AMER WATER WORKS ASSOC C1 USA,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL 61826. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER WATER WORKS ASSOC PI DENVER PA 6666 WEST QUINCY AVE, DENVER, CO 80235 BN 0-89867-618-5 PY 1992 BP 325 EP 340 PG 16 WC Biotechnology & Applied Microbiology; Chemistry, Applied; Water Resources SC Biotechnology & Applied Microbiology; Chemistry; Water Resources GA BA61B UT WOS:A1992BA61B00022 ER PT J AU GOICOECHEA, A STAKHIV, EZ LI, F AF GOICOECHEA, A STAKHIV, EZ LI, F TI EXPERIMENTAL EVALUATION OF MULTIPLE CRITERIA DECISION-MODELS FOR APPLICATION TO WATER-RESOURCES PLANNING SO WATER RESOURCES BULLETIN LA English DT Article DE MULTIPLE CRITERIA DECISION MAKING; DECISION SUPPORT SYSTEMS; WATER RESOURCES PLANNING; EXPERIMENTS IN DECISION MAKING; DESIGN OF COMPUTER-BASED DECISION SUPPORT SYSTEMS ID UTILITY AB A research project was undertaken for the U.S. Army Corps of Engineers to determine the relative utility and effectiveness of four well-known multicriteria decision making (MCDM) models for applications in realistic water resources planning settings. A series of experiments was devised to examine the impact of rating and ranking procedures on the decision making behavior of users (e.g., planners, managers, analysts, etc.) when faced with situations involving multiple evaluation criteria and numerous alternative planning projects. The four MCDM models tested were MATS-PC, EXPERT CHOICE, ARIADNE, and ELECTRE. Two groups of analysts and decision makers were tested. One group consisted of experienced U.S. Army Corps planners, while the other was comprised of graduate students. Based on a series of nonparametric statistical tests, the results identified EXPERT CHOICE as the preferred MCDM model by both groups based largely on ease of use and understandability. ARIADNE fostered the largest degree of agreement within and among the two groups of individuals tested. The tests also lend support to the claim that rankings are not affected significantly by the choice of decision maker (i.e., who uses any of these MCDM models) or which of these four models is used. C1 GEORGE MASON UNIV,DEPT INFORMAT SYST & SYST ENGN,FAIRFAX,VA 22030. USA CORPS ENGINEERS,DIV SPECIAL STUDIES,FT BELVOIR,VA 22060. RP GOICOECHEA, A (reprint author), STATCOM INC,DIV RES & ANAL,7921 JONES BRANCH DR,MCLEAN,VA 22060, USA. NR 32 TC 14 Z9 14 U1 0 U2 2 PU AMER WATER RESOURCES ASSOC PI HERNDON PA 950 HERNDON PARKWAY SUITE 300, HERNDON, VA 20170-5531 SN 0043-1370 J9 WATER RESOUR BULL JI Water Resour. Bull. PD JAN-FEB PY 1992 VL 28 IS 1 BP 89 EP 102 PG 14 WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA HZ734 UT WOS:A1992HZ73400008 ER PT J AU SANIN, DF VESILIND, PA MARTEL, JJ AF SANIN, DF VESILIND, PA MARTEL, JJ TI PATHOGEN REDUCTION CAPABILITIES OF FREEZE THAW SLUDGE CONDITIONING SO WATER SCIENCE AND TECHNOLOGY LA English DT Note C1 USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. RP SANIN, DF (reprint author), DUKE UNIV,DEPT CIVIL & ENVIRONM ENGN,DURHAM,NC 27706, USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0273-1223 J9 WATER SCI TECHNOL JI Water Sci. Technol. PY 1992 VL 26 IS 9-11 BP 2183 EP 2183 PG 1 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA KA669 UT WOS:A1992KA66900049 ER PT J AU BUNCH, BW GRIFFIN, DM AF BUNCH, BW GRIFFIN, DM TI RAPID REMOVAL OF COLLOIDAL ORGANICS FROM DOMESTIC WASTE-WATER SO WATER SCIENCE AND TECHNOLOGY LA English DT Article; Proceedings Paper CT 16TH BIENNIAL CONF OF THE INTERNATIONAL ASSOC ON WATER POLLUTION RESEARCH AND CONTROL CY MAY 24-30, 1992 CL WASHINGTON, DC SP INT ASSOC WATER POLLUT RES & CONTROL DE WASTE-WATER TREATMENT; ACTIVATED SLUDGE PROCESS; CONTACT STABILIZATION; COLLOID; ADSORPTION; MICROBIAL SLUDGE AB Batch experiments were conducted with raw wastewater and preaerated microbial sludge to investigate the removal behavior of the contact stabilization activated sludge process. This process was originally developed based on observed rapid drops in BOD which were attributed to rapid adsorption of colloidal organics. To date no data have been presented verifying that rapid colloidal adsorption occurs or is responsible for rapid BOD decreases. Food to Microorganism (F:M) ratios were varied from 0.047 to 0.447 mg COD/mg MLSS during batch tests conducted with thirty minute contact times. Mixed liquor samples were collected at predetermined times, poisoned with mercuric chloride to halt microbial activity, and settled. Samples of the supernatant were drawn off and the COD of organics in different size ranges determined using a sequential filtering technique. Colloidal COD was defined to be the difference between the COD of organics passing a 1.5 mum filter and those passing a 0.03 mum filter. Results indicated that rapid colloidal removal occurred. Colloidal COD concentrations decreased from initial values (maximum 85 mg/l) to near 0 mg/l within five minutes after mixing. Such behavior was only observed for the colloidal fraction and occurred regardless of the initial colloidal COD, total COD, or F:M ratio. It was concluded that physical coagulation was most likely the mechanism responsible for rapid colloidal removal. C1 LOUISIANA TECH UNIV,DEPT CIVIL ENGN,RUSTON,LA 71272. RP BUNCH, BW (reprint author), WATERWAYS EXPT STN,ENVIRONM LAB,WATER QUAL MODELING GRP,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 5 TC 1 Z9 1 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0273-1223 J9 WATER SCI TECHNOL JI Water Sci. Technol. PY 1992 VL 26 IS 9-11 BP 2433 EP 2436 PG 4 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA KA669 UT WOS:A1992KA66900112 ER PT J AU VIDIC, RD SUIDAN, MT BRENNER, RC AF VIDIC, RD SUIDAN, MT BRENNER, RC TI EFFECT OF DISSOLVED-OXYGEN ON PHENOLS BREAKTHROUGH FROM GAC ADSORBERS (WATER SCIENCE AND TECHNOL, VOL 26, PG 1185, 1992) SO WATER SCIENCE AND TECHNOLOGY LA English DT Correction, Addition C1 USA,EPA,RREL,CINCINNATI,OH 45268. RP VIDIC, RD (reprint author), UNIV CINCINNATI,DEPT SOIL & WATER SCI,CINCINNATI,OH 45221, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0273-1223 J9 WATER SCI TECHNOL JI Water Sci. Technol. PY 1992 VL 26 IS 12 BP 2741 EP 2741 PG 1 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA KJ403 UT WOS:A1992KJ40300014 ER PT J AU KOH, G AF KOH, G TI EXPERIMENTAL-STUDY OF ELECTROMAGNETIC-WAVE PROPAGATION IN DENSE RANDOM-MEDIA SO WAVES IN RANDOM MEDIA LA English DT Article AB Controlled experiments have been conducted to measure the propagation of synthetically generated pulses in dense random media. The dense media were prepared by embedding spherical dielectric scatterers in a homogeneous background medium; the size and volume fraction of the scatterers were the controlled parameters. A network analyser-based system operating in the frequency domain was used to measure the electric field reflected and transmitted by slab-shaped samples of dense media as the source signal was swept from 26.5 to 40 GHz. An inverse Fourier transform was used to convert the frequency domain response into time domain pulse waveforms. The time domain response was then used to obtain pulse propagation velocity and attenuation in the controlled samples. The experimental results are shown to be in general agreement with dense medium theories. RP KOH, G (reprint author), USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 0 TC 8 Z9 9 U1 1 U2 1 PU IOP PUBLISHING LTD PI BRISTOL PA TECHNO HOUSE, REDCLIFFE WAY, BRISTOL, ENGLAND BS1 6NX SN 0959-7174 J9 WAVE RANDOM MEDIA JI Waves Random Media PD JAN PY 1992 VL 2 IS 1 BP 39 EP 48 DI 10.1088/0959-7174/2/1/004 PG 10 WC Physics, Multidisciplinary SC Physics GA HN302 UT WOS:A1992HN30200004 ER PT J AU PRUITT, BA AF PRUITT, BA TI PROGRESS IN BURN CARE - INTRODUCTION SO WORLD JOURNAL OF SURGERY LA English DT Editorial Material RP PRUITT, BA (reprint author), USA,INST SURG RES,LIB BRANCH,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 4 Z9 4 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0364-2313 J9 WORLD J SURG JI World J.Surg. PD JAN-FEB PY 1992 VL 16 IS 1 BP 1 EP 1 PG 1 WC Surgery SC Surgery GA GZ119 UT WOS:A1992GZ11900001 PM 1290248 ER PT J AU PRUITT, BA MCMANUS, AT AF PRUITT, BA MCMANUS, AT TI THE CHANGING EPIDEMIOLOGY OF INFECTION IN BURN PATIENTS SO WORLD JOURNAL OF SURGERY LA English DT Article ID RESISTANT STAPHYLOCOCCUS-AUREUS; METHICILLIN-RESISTANT; WOUND BIOPSY; THROMBOPHLEBITIS; COMPLICATIONS; BACTEREMIA; DIAGNOSIS; PNEUMONIA; MORTALITY; THERAPY AB Topical chemotherapy, prompt excision, and timely closure of the burn wound have significantly reduced the occurrence of invasive burn wound infection and its related mortality. Since wound protection is imperfect and invasive wound infection may still occur in patients with massive burns in whom wound closure is delayed, scheduled wound surveillance and biopsy monitoring are necessary to assess the microbial status of the burn wound and identify wound infections caused by resistant bacteria or non-bacterial opportunists at a stage when therapeutic intervention can control the process. As a reflection of the systemic immunosuppressive effects of burn injury, infection remains the most common cause of morbidity and mortality even though the occurrence of wound infections has been significantly decreased. Pneumonia is the most frequent infection occurring in burn patients today but the improvements in patient management, wound care, and infection control have made bronchopneumonia the most common form of this infection and gram-positive organisms the most common causative agents. The organisms causing bacteremia that exert a species specific effect on the mortality related to extent of burn injury and patient age have changed in concert with changes in wound flora. Infection control procedures, including scheduled surveillance cultures, utilization of cohort patient care methodology, strict enforcement of patient and staff hygiene, and patient monitoring have been effective in eliminating endemic resistant microbial strains, preventing the establishment of newly introduced resistant organisms, diagnosing infection in a timely fashion, instituting antibiotic and other necessary therapy in a prompt manner, and documenting the effectiveness of present day burn patient care and the improved survival of burn patients. RP PRUITT, BA (reprint author), USA,INST SURG RES,LIB BRANCH,FT SAM HOUSTON,TX 78234, USA. NR 47 TC 60 Z9 68 U1 0 U2 1 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0364-2313 J9 WORLD J SURG JI World J.Surg. PD JAN-FEB PY 1992 VL 16 IS 1 BP 57 EP 67 PG 11 WC Surgery SC Surgery GA GZ119 UT WOS:A1992GZ11900011 PM 1290268 ER PT J AU SHAW, RW BRILL, TB CLIFFORD, AA ECKERT, CA FRANCK, EU AF SHAW, RW BRILL, TB CLIFFORD, AA ECKERT, CA FRANCK, EU TI SUPERCRITICAL WATER - A MEDIUM FOR CHEMISTRY SO CHEMICAL & ENGINEERING NEWS LA English DT Article C1 USA,RES OFF,WASHINGTON,DC 20310. UNIV DELAWARE,NEWARK,DE 19711. UNIV LEEDS,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND. GEORGIA INST TECHNOL,ATLANTA,GA 30332. UNIV KARLSRUHE,W-7500 KARLSRUHE,GERMANY. NR 6 TC 487 Z9 516 U1 8 U2 51 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0009-2347 J9 CHEM ENG NEWS JI Chem. Eng. News PD DEC 23 PY 1991 VL 69 IS 51 BP 26 EP 39 PG 14 WC Chemistry, Multidisciplinary; Engineering, Chemical SC Chemistry; Engineering GA GW796 UT WOS:A1991GW79600017 ER PT J AU ABRAHAM, MH WHITING, GS DOHERTY, RM SHUELY, WJ AF ABRAHAM, MH WHITING, GS DOHERTY, RM SHUELY, WJ TI HYDROGEN-BONDING .16. A NEW SOLUTE SOLVATION PARAMETER, PI-2(H), FROM GAS-CHROMATOGRAPHIC DATA SO JOURNAL OF CHROMATOGRAPHY LA English DT Article ID WATER PARTITION-COEFFICIENTS; LOG K-VALUES; LIQUID-CHROMATOGRAPHY; STATIONARY PHASES; SOLUBILITY PROPERTIES; BIOLOGICAL MEDIA; TETRACHLOROMETHANE; COMPLEXATION; BASICITY; POLYMERS AB The general solvation equation, log V(G)0 (or log L) = c + rR2 + s-pi(2)H + a-alpha(2)H + b-beta(2)H + l log L16 has been used to set up a new pi(2)H parameter of solute dipolarity-polarisability, mainly through the extensive data of McReynolds and Patte et al. Values of pi(2)H are tabulated for several hundred solutes, and two simple rules have been formulated to enable pi(2)H to be estimated for many types of aliphatic functionally substituted compounds. A coherent set of effective solvation parameters, SIGMA-pi(2)H, SIGMA-alpha(2)H, SIGMA-beta(2)H, and also R2 and log L16, allows the application of the general solvation equation to the characterisation of any gas-liquid chromatographic stationary phase. C1 USN, CTR SURFACE WARFARE, WHITE OAK LAB, SILVER SPRING, MD 20910 USA. USA, CTR CHEM RES DEV & ENGN, ABERDEEN PROVING GROUND, MD 21010 USA. RP UNIV LONDON UNIV COLL, DEPT CHEM, 20 GORDON ST, LONDON WC1H 0AJ, ENGLAND. NR 21 TC 227 Z9 229 U1 2 U2 19 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0021-9673 J9 J CHROMATOGR PD DEC 20 PY 1991 VL 587 IS 2 BP 213 EP 228 DI 10.1016/0021-9673(91)85158-C PG 16 WC Chemistry, Analytical SC Chemistry GA GY996 UT WOS:A1991GY99600010 ER PT J AU ABRAHAM, MH WHITING, GS DOHERTY, RM SHUELY, WJ AF ABRAHAM, MH WHITING, GS DOHERTY, RM SHUELY, WJ TI HYDROGEN-BONDING .17. THE CHARACTERIZATION OF 24 GAS-LIQUID-CHROMATOGRAPHIC STATIONARY PHASES STUDIED BY POOLE AND COWORKERS, INCLUDING MOLTEN-SALTS, AND EVALUATION OF SOLUTE STATIONARY PHASE INTERACTIONS SO JOURNAL OF CHROMATOGRAPHY LA English DT Article ID SOLVENT STRENGTH; SELECTIVITY; POLARITY; SET AB The general solvation equation log K = c + rR2 + s-pi(2)H + a-alpha(2)H + b-beta(2)H + l log L16 has been used to characterise 24 gas-liquid chromatographic stationary phases for which Poole and co-workers have determined log K values for a series of solutes at 121.4-degrees-C. The explanatory variables are R2, a solute excess molar refraction, pi(2)H, the solute dipolarity, alpha(2)H and beta(2)H, the solute hydrogen-bond acidity and basicity, and log L16, where L16 is the solute gas-liquid partition coefficient on hexadecane at 25-degrees-C. It is shown that the b-beta(2)H term is not significant for any phase, and that the molten salts are all strongly dipolar and basic, with large s and a constants. A term-by-term analysis of the solvation equation yields a quantitative measure of the contribution to log K of various solute-stationary phase interactions, and leads to an understanding of how these interactions affect solute retention. The use of the characteristic constants c, r, s, a, b and l in the selection of stationary phases for particular separations is described. C1 USN, CTR SURFACE WARFARE, WHITE OAK LAB, SILVER SPRING, MD 20910 USA. USA, CTR CHEM RES DEV & ENGN, ABERDEEN PROVING GROUND, MD 21010 USA. RP UNIV LONDON UNIV COLL, DEPT CHEM, 20 GORDON ST, LONDON WC1H 0AJ, ENGLAND. NR 15 TC 112 Z9 113 U1 1 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0021-9673 J9 J CHROMATOGR PD DEC 20 PY 1991 VL 587 IS 2 BP 229 EP 236 DI 10.1016/0021-9673(91)85159-D PG 8 WC Chemistry, Analytical SC Chemistry GA GY996 UT WOS:A1991GY99600011 ER PT J AU MODESTO, VL SATAVA, RM AF MODESTO, VL SATAVA, RM TI OPERATING UNDER THE THREAT OF CHEMICAL-BIOLOGICAL WARFARE SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Letter RP MODESTO, VL (reprint author), USA,8TH EVACUAT HOSP SAUDI ARABIA,WASHINGTON,DC 20310, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD DEC 18 PY 1991 VL 266 IS 23 BP 3281 EP 3282 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA GU964 UT WOS:A1991GU96400011 PM 1960821 ER PT J AU SARNO, AP AF SARNO, AP TI MORE ON DESERT STORM SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Letter RP SARNO, AP (reprint author), TRIPLER ARMY MED CTR,HONOLULU,HI 96859, USA. NR 4 TC 1 Z9 1 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD DEC 18 PY 1991 VL 266 IS 23 BP 3282 EP 3282 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA GU964 UT WOS:A1991GU96400012 ER PT J AU KEELER, JR HURST, CG DUNN, MA AF KEELER, JR HURST, CG DUNN, MA TI MORE ON DESERT STORM - REPLY SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Letter RP KEELER, JR (reprint author), USA,MED RES INST,ABERDEEN PROVING GROUND,MD 21010, USA. NR 2 TC 0 Z9 0 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD DEC 18 PY 1991 VL 266 IS 23 BP 3283 EP 3283 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA GU964 UT WOS:A1991GU96400014 ER PT J AU CHOI, KK FOTIADIS, L TAYSINGLARA, M CHANG, W IAFRATE, GJ AF CHOI, KK FOTIADIS, L TAYSINGLARA, M CHANG, W IAFRATE, GJ TI HIGH DETECTIVITY INGAAS BASE INFRARED HOT-ELECTRON TRANSISTOR SO APPLIED PHYSICS LETTERS LA English DT Article ID QUANTUM WELLS; DARK CURRENT; DETECTOR; PHOTODETECTORS; SUPERLATTICES AB An infrared hot-electron transistor with a thin (300 angstrom)InGaAs base layer is constructed. By adopting a thin base material with a large GAMMA-L valley separation, the photocurrent transfer ratio is improved by a factor of four in comparison with the GaAs base transistor. As a result, the detectivity of the transistor is increased to 1.4 X 10(10) cm square-root Hz/W at 77 K with a cutoff wavelength of 9.5-mu-m, two times as large as the companion state-of-the-art GaAs quantum well photoconductor. Combined with the lower dark current, the voltage responsivity and the noise equivalent temperature difference of a detector array can be improved by more than an order of magnitude. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP CHOI, KK (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. RI Choi, Kwong-Kit/K-9205-2013 NR 21 TC 24 Z9 24 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD DEC 16 PY 1991 VL 59 IS 25 BP 3303 EP 3305 DI 10.1063/1.105713 PG 3 WC Physics, Applied SC Physics GA GV079 UT WOS:A1991GV07900034 ER PT J AU WALKER, CW SLANE, SM AF WALKER, CW SLANE, SM TI LITHIUM RECHARGEABLE CELL WITH A POLY 3-METHYLTHIOPHENE CATHODE AND LIASF6-DIMETHYL CARBONATE ELECTROLYTE SO JOURNAL OF POWER SOURCES LA English DT Note ID POLY(3-METHYLTHIOPHENE) AB A poly 3-methylthiophene cathode showed excellent coulombic efficiency during cycling in a lithium rechargeable cell. A dimethyl carbonate electrolyte was used since it is stable at the high anodic potentials reached during cell charging. The polymer cathode tolerated modest overcharge and was able to continue cycling after a severe short circuit with minimal loss in capacity. RP WALKER, CW (reprint author), USA,LABCOM,DIV POWER SOURCES,FT MONMOUTH,NJ 07703, USA. NR 7 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD DEC 16 PY 1991 VL 36 IS 4 BP 561 EP 566 DI 10.1016/0378-7753(91)80082-9 PG 6 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA GW380 UT WOS:A1991GW38000016 ER PT J AU SEALY, BJ AF SEALY, BJ TI GRUNT SO NEW REPUBLIC LA English DT Letter C1 USA,FT RICHARDSON,AR. NR 1 TC 0 Z9 0 U1 0 U2 0 PU NEW REPUBLIC INC PI WASHINGTON PA 1220 19TH ST NW SUITE 600, WASHINGTON, DC 20036 SN 0028-6583 J9 NEW REPUBLIC JI New Repub. PD DEC 16 PY 1991 VL 205 IS 25 BP 2 EP 2 PG 1 WC Political Science SC Government & Law GA GT933 UT WOS:A1991GT93300001 ER PT J AU ROSSMAN, DI MULLER, AJ LEWIS, EO AF ROSSMAN, DI MULLER, AJ LEWIS, EO TI SOME NEW CHEMISTRY OF PERFLUORO-TERT-BUTYLSILVER SO JOURNAL OF FLUORINE CHEMISTRY LA English DT Article AB Perfluoro-t-butylsilver, prepared by the reaction of silver fluoride with perfluoroisobutene, has been used to prepare new perfluoro-t-butyl derivatives in good yield. RP ROSSMAN, DI (reprint author), USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010, USA. NR 6 TC 7 Z9 7 U1 0 U2 1 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0022-1139 J9 J FLUORINE CHEM JI J. Fluor. Chem. PD DEC 15 PY 1991 VL 55 IS 2 BP 221 EP 224 DI 10.1016/S0022-1139(00)80125-6 PG 4 WC Chemistry, Inorganic & Nuclear; Chemistry, Organic SC Chemistry GA HM086 UT WOS:A1991HM08600013 ER PT J AU SWAB, JJ AF SWAB, JJ TI LOW-TEMPERATURE DEGRADATION OF Y-TZP MATERIALS SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID TETRAGONAL ZIRCONIA POLYCRYSTALS; TRANSFORMATION; WATER AB Seven yttria-tetragonal zirconia polycrystal (TZP) materials were examined to determine if they were susceptible to low temperature degradation. Flexure specimens were exposed to approximately 800 Pa of water vapour pressure for 50 h between 200 and 400-degrees-C. Only one of the TZPs was unaffected by these low temperature treatments. Three underwent catastrophic degradation after all the low temperature treatments, while the final three had property losses of varying degrees, depending on the treatment temperature. RP SWAB, JJ (reprint author), USA,MAT TECHNOL LAB,WATERTOWN,MA 02172, USA. NR 19 TC 70 Z9 70 U1 1 U2 7 PU CHAPMAN HALL LTD PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8HN SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD DEC 15 PY 1991 VL 26 IS 24 BP 6706 EP 6714 DI 10.1007/BF02402664 PG 9 WC Materials Science, Multidisciplinary SC Materials Science GA GX648 UT WOS:A1991GX64800023 ER PT J AU CHANG, FC LEVY, M HUIE, R KANE, M BUCKLEY, P KATTAMIS, TZ LAKSHMINARAYAN, GR AF CHANG, FC LEVY, M HUIE, R KANE, M BUCKLEY, P KATTAMIS, TZ LAKSHMINARAYAN, GR TI ADHESION AND CORROSION BEHAVIOR OF AL-ZN AND TIN/TI/TIN COATINGS ON A DU-0.75WT-PERCENT TI ALLOY SO SURFACE & COATINGS TECHNOLOGY LA English DT Article; Proceedings Paper CT 18TH INTERNATIONAL CONF ON METALLURGICAL COATINGS AND THIN FILMS CY APR 22-26, 1991 CL SAN DIEGO, CA SP AMER VACUUM SOC, DIV VACUUM TECHNOL, AMER VACUUM SOC, DIV THIN FILMS AB Al-Zn alloy and multilayer TiN/Ti/TiN thin coatings were deposited on DU-0.75Ti alloy specimens by a cathodic are plasma physical vapor deposition process. The quality, soundness and adhesion of the coatings to the substrate were evaluated by automatic scratch testing, in combination with optical and scanning electron microscopy examination of the scratch morphology. The galvanic corrosion behavior of DU-0.75Ti alloy coupled to the coated alloys and aluminum alloy 7075-T6 was also investigated by electrochemical tests in a 0.5 N NaCl aqueous solution. C1 UNIV CONNECTICUT,DEPT MET,STORRS,CT 06269. US ARMAMENT RESEARCH DEV & ENGN CTR,PICATINNY ARSENAL,NJ 07806. RP CHANG, FC (reprint author), USA,MAT TECHNOL LAB,WATERTOWN,MA 02172, USA. NR 9 TC 14 Z9 17 U1 0 U2 3 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0257-8972 J9 SURF COAT TECH JI Surf. Coat. Technol. PD DEC 10 PY 1991 VL 49 IS 1-3 BP 87 EP 96 DI 10.1016/0257-8972(91)90037-W PG 10 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA GX591 UT WOS:A1991GX59100017 ER PT J AU DESISTO, WJ HENRY, RL OSOFSKY, M MARZIK, JV AF DESISTO, WJ HENRY, RL OSOFSKY, M MARZIK, JV TI YBA2CU3O7-DELTA THIN-FILMS DEPOSITED BY AN ULTRASONIC NEBULIZATION AND PYROLYSIS METHOD SO THIN SOLID FILMS LA English DT Article; Proceedings Paper CT 18TH INTERNATIONAL CONF ON METALLURGICAL COATINGS AND THIN FILMS CY APR 22-26, 1991 CL SAN DIEGO, CA ID CHEMICAL VAPOR-DEPOSITION; TC SUPERCONDUCTING FILMS; SPRAY PYROLYSIS; TARGET; GROWTH AB High T(c) superconducting Films of YBa2Cu3O7-delta were deposited by a novel chemical vapor deposition procedure. 1-butanol solutions of the volatile yttrium, barium and copper derivatives of 2,2,6,6-tetramethyl-3,5-heptanedione were ultrasonically nebulized and pyrolyzed onto MgO substrates at 430-degrees-C. The solutions were nebulized with "soft spray" ultrasonic nozzles operating at 60 and 120 kHz giving median droplet sizes of 19 and 10-mu-m respectively. Experimental parameters affecting film composition are discussed. The as-deposited films were poorly crystalline. Annealing the films in flowing argon at 830-degrees-C, was followed by a short anneal in O2 at 880-degrees-C and slow cooling in O2. The films were metallic with T(c) values as high as 80-81 K (R = 0). Films were characterized by X-ray diffraction, optical and scanning electron microscopy, elastic backscattering and transport measurements. C1 USA,MAT TECHNOL LAB,WATERTOWN,MA 02172. RP DESISTO, WJ (reprint author), USN,RES LAB,WASHINGTON,DC 20375, USA. NR 20 TC 7 Z9 7 U1 1 U2 2 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0040-6090 J9 THIN SOLID FILMS JI Thin Solid Films PD DEC 10 PY 1991 VL 206 IS 1-2 BP 128 EP 131 DI 10.1016/0040-6090(91)90406-N PG 4 WC Materials Science, Multidisciplinary; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA GZ322 UT WOS:A1991GZ32200023 ER PT J AU PIERCE, DE BURNS, RP GABRIEL, KA AF PIERCE, DE BURNS, RP GABRIEL, KA TI THERMAL-DESORPTION SPECTROSCOPY OF PALLADIUM AND COPPER ON SILICA SO THIN SOLID FILMS LA English DT Article; Proceedings Paper CT 18TH INTERNATIONAL CONF ON METALLURGICAL COATINGS AND THIN FILMS CY APR 22-26, 1991 CL SAN DIEGO, CA ID SURFACE AB Thermal desorption spectroscopy of palladium and copper films grown on clean silica substrates was performed using CO2 laser heating. After cleaning the surface by high temperature heating, a controlled, low coverage dose of metal atoms was deposited on the substrate. Temperature ramping was achieved using a constant laser power, the value of which depended on the nature of the metal and substrate as well as the substrate size. At high temperatures (above 1025 K for palladium and above 975 K for copper), metal films vaporize and desorption spectra provide information about the nature of the metal deposit and metal-support interaction. With increasing coverage of palladium on silica, a positive temperature shift in the leading edge of desorption was seen. At higher coverages, above about 2 x 10(15) atoms cm-2, a common leading edge appears and zero-order kinetic analysis gave E(act) values between 3.9 and 4.3 +/- 0.1 eV which can be compared with the value of 3.83 eV for DELTA-H(vap)(1200 K) for palladium metal. Similar coverage-dependent properties were not seen for copper on silica; instead. a common desorption leading edge appeared down to submonolayer coverages. Zero-order analysis at about 1 x 10(15) atoms cm-2 gave an E(act) of 3.3 +/- 0.1 eV. which is comparable with the value of 3.44 eV for DELTA-H(vap)(1100 K) for copper metal. C1 USA,MAT TECHNOL LAB,WATERTOWN,MA 02172. RP PIERCE, DE (reprint author), UNIV ILLINOIS,DEPT CHEM,POB 4348,M-C 111,CHICAGO,IL 60680, USA. NR 25 TC 13 Z9 13 U1 1 U2 5 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0040-6090 J9 THIN SOLID FILMS JI Thin Solid Films PD DEC 10 PY 1991 VL 206 IS 1-2 BP 340 EP 344 DI 10.1016/0040-6090(91)90447-6 PG 5 WC Materials Science, Multidisciplinary; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA GZ322 UT WOS:A1991GZ32200064 ER PT J AU DUNCAN, WA ROGERS, BJ HOLLOMAN, ME PATTERSON, SP AF DUNCAN, WA ROGERS, BJ HOLLOMAN, ME PATTERSON, SP TI HYDROGEN-FLUORIDE OVERTONE CHEMICAL-LASER TECHNOLOGY SO AIAA JOURNAL LA English DT Article AB The Hydrogen Fluoride Overtone Chemical Laser Technology Program has exploited the technology base developed over the last two decades for hydrogen fluoride lasers and successfully demonstrated a short wavelength chemical laser. This technology development centers on overtone lasing of the hydrogen fluoride molecule to produce laser radiation at 1.33-mu-m rather than the conventional fundamental lasing at 2.8-mu-m. The overtone wavelength can lead to significant improvements in brightness potential as well as atmospheric propagation properties. The concept has matured from initial demonstrations at the 10 W scale to the currently demonstrated multikilowatt level. In the course of these test programs, it was necessary to develop new highly reflective coatings that permitted short wavelength lasing while completely suppressing lasing on the fundamental. This paper briefly reviews the performance of both discharge-driven and combustion-driven chemical laser devices and the optical configurations employed in the scalability steps. Appropriate diagnostics are discussed, including power, efficiency, spectra, and small signal gain. RP DUNCAN, WA (reprint author), USA,MISSILE COMMAND,AMSMI,RD,WS,LS,REDSTONE ARSENAL,AL 35898, USA. NR 12 TC 2 Z9 3 U1 1 U2 1 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0001-1452 J9 AIAA J JI AIAA J. PD DEC PY 1991 VL 29 IS 12 BP 2181 EP 2184 DI 10.2514/3.10857 PG 4 WC Engineering, Aerospace SC Engineering GA GX692 UT WOS:A1991GX69200023 ER PT J AU MCCOLLOUGH, ML GLOVER, AT GRABSKI, WJ BERGER, TG AF MCCOLLOUGH, ML GLOVER, AT GRABSKI, WJ BERGER, TG TI ORBITAL DERMOID CYSTS SHOWING CONJUNCTIVAL EPITHELIUM SO AMERICAN JOURNAL OF DERMATOPATHOLOGY LA English DT Article DE DERMOID CYSTS; ORBITAL AREA; CONJUNCTIVAL EPITHELIUM AB The orbital area is one of the most common sites for dermoid cysts. Most often these cysts are lined by keratinizing squamous epithelium; however, dermoid cysts may rarely be lined with conjunctival epithelium. We describe such a cyst and the features that distinguish it from other dermoid cysts. C1 PERMANENTE MED GRP INC,DEPT OPHTHALMOL,SACRAMENTO,CA. RP MCCOLLOUGH, ML (reprint author), BROOKE ARMY MED CTR,DERMATOL SERV,FT SAM HOUSTON,TX 78234, USA. NR 10 TC 8 Z9 8 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0193-1091 J9 AM J DERMATOPATH JI Am. J. Dermatopathol. PD DEC PY 1991 VL 13 IS 6 BP 611 EP 615 PG 5 WC Dermatology SC Dermatology GA GW412 UT WOS:A1991GW41200012 PM 1805655 ER PT J AU SCOTT, DA CORWIN, AL CONSTANTINE, NT OMAR, MA GULED, A YUSEF, M ROBERTS, CR WATTS, DM AF SCOTT, DA CORWIN, AL CONSTANTINE, NT OMAR, MA GULED, A YUSEF, M ROBERTS, CR WATTS, DM TI LOW PREVALENCE OF HUMAN IMMUNODEFICIENCY VIRUS-1 (HIV-1), HIV-2, AND HUMAN T-CELL LYMPHOTROPIC VIRUS-1 INFECTION IN SOMALIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID HTLV-I ANTIBODIES; LEUKEMIA-VIRUS; AFRICA; AIDS; MEN; POPULATIONS; DJIBOUTI; TYPE-1; RISK AB A seroepidemiologic survey was conducted to determine the prevalence of human immunodeficiency virus type 1 (HIV-1), HIV-2, human T cell lymphotropic virus type I (HTLV-I), and Treponema pallidum infection among southern Somalis. Sera were collected from 1, 269 study subjects in the urban area of the capital city, Mogadishu, and in the rural towns of Merka, Qoryoley, and Kismayo. The subjects included 57 prostitutes, 79 sexually transmitted disease (STD) patients, and 1, 133 others, including outpatient and hospitalized patients with leprosy, tuberculosis, other infectious diseases, individuals from rehabilitation camps and secondary schools, and Ethiopian immigrants. Results indicated that none of the sera were positive for HIV-1 and HIV-2 by Western blot, but one was positive for HTLV-1. The prostitutes had a significantly higher prevalence of treponemal antibody (50.8%; P < 0.0001) than either the STD patients (12.6%) or the other subjects (5.2%). Epidemiologic data indicated that 94% of the males and females were circumcised and only 2.6% of the males used condoms. Overall, the results of this study suggested a very low prevalence of HIV-1, HIV-2, and HTLV-I infections, especially among prostitutes and STD patients, who were considered at greatest risk of contracting these retroviral infections. C1 USN,MED RES UNIT 3,CAIRO,EGYPT. MINIST HLTH,STD PROJECT,MUQDISHO,SOMALIA. WALTER REED ARMY MED CTR,DIV RETROVIROL,WASHINGTON,DC 20307. NR 25 TC 18 Z9 18 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 1991 VL 45 IS 6 BP 653 EP 659 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA HA015 UT WOS:A1991HA01500001 PM 1763791 ER PT J AU GROGL, M KREUTZER, RD MCHUGH, CP MARTIN, RK AF GROGL, M KREUTZER, RD MCHUGH, CP MARTIN, RK TI CHARACTERIZATION OF A LEISHMANIA ISOLATE FROM THE RODENT HOST NEOTOMA-MICROPUS COLLECTED IN TEXAS AND COMPARISON WITH HUMAN ISOLATES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID CUTANEOUS LEISHMANIASIS; DERMAL LEISHMANIASIS; GEL-ELECTROPHORESIS; MOLECULAR KARYOTYPE; MEXICANA; SEPARATION; YEAST; GENE; DNAS AB We report the biological and biochemical parameters of Leishmania parasites (MNEO/US/90/WR972) isolated from a rodent host, Neotoma micropus, collected in Texas. Footpad inoculations of WR972 promastigotes into BALB/c mice and Syrian hamsters resulted in ulcerating lesions six and eight weeks post-inoculation, respectively. Using monoclonal antibody-stained touch preparations, amastigotes were found in the liver of both laboratory hosts. Infection of J774 macrophages with WR972 promastigotes supported the growth of amastigotes for 12 days at 35-degrees-C. The WR972 parasite was identified by enzyme electrophoresis as L. mexicana. Isozyme comparison of WR972 with 42 L. mexicana isolates (from humans and rodents) from four different endemic areas, including Texas, suggest that these parasite populations are identical for approximately 97% of their genetic loci. Pulse field gel electrophoresis (PFGE) of WR972 resolved 18 chromosomes with a size range of 300- > 2,000 kb. The karyotype strongly resembles that of two other Texas L. mexicana isolates from humans. Taken together, the PFGE, hybridization, and isoenzyme data suggest that the wood rat isolate (WR972) is identical to parasites from human cutaneous lesions isolated in Texas and Central America. In addition, the biological characteristics of WR972, its infectivity of BALB/c mice and the Syrian hamster, and the potential of the isolate to infect, transform, and divide in J774 macrophages indicate that WR972 will be pathogenic in humans if transmission occurs. Health care providers should consider this possibility when studying the epidemiology and control of cutaneous leishmaniasis in Texas. C1 YOUNGSTOWN STATE UNIV,DEPT BIOL,YOUNGSTOWN,OH 44555. USAF,SCH AEROTHERM,DIV EPIDEMIOL,BROOKS AFB,TX 78235. RP GROGL, M (reprint author), WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,LEISHMANIA SECT,BLDG 500,WASHINGTON,DC 20307, USA. NR 28 TC 8 Z9 8 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 1991 VL 45 IS 6 BP 714 EP 722 PG 9 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA HA015 UT WOS:A1991HA01500010 PM 1763798 ER PT J AU CAPPS, JL AF CAPPS, JL TI POSITIVE AS SOUND - DICKINSON,EMILY RHYME - SMALL,JJ SO AMERICAN LITERATURE LA English DT Book Review RP CAPPS, JL (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU DUKE UNIV PRESS PI DURHAM PA BOX 90660, DURHAM, NC 27708-0660 SN 0002-9831 J9 AM LIT JI Am. Lit. PD DEC PY 1991 VL 63 IS 4 BP 748 EP 749 DI 10.2307/2926887 PG 2 WC Literature, American SC Literature GA GT299 UT WOS:A1991GT29900017 ER PT J AU ANDERS, GT LINVILLE, KC JOHNSON, JE BLANTON, HM AF ANDERS, GT LINVILLE, KC JOHNSON, JE BLANTON, HM TI EVALUATION OF THE FLOAT SIGN FOR DETERMINING ADEQUACY OF SPECIMENS OBTAINED WITH TRANSBRONCHIAL BIOPSY SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Note ID TRANS-BRONCHIAL BIOPSY AB This study prospectively evaluated the alveolar content of transbronchial biopsy specimens based on whether or not they floated in formalin. One hundred biopsy specimens were obtained from 18 patients. Specimens with any alveoli were significantly more likely to float (45 of 61, 74%) than those with no alveolar tissue (15 of 39, 39%; p < 0.001). The majority of diagnostic specimens were obtained in eight patients with sarcoidosis, where 47 biopsies were obtained. Fourteen of 19 specimens (74%) with noncaseating granulomas floated, whereas only 11 of 28 (39%; p < 0.05) nondiagnostic specimens floated. The results of this study suggest that this simple bedside observation may serve to determine the adequacy of transbronchial biopsy specimens, particularly in sarcoidosis. C1 BROOKE ARMY MED CTR,DEPT PATHOL,FT SAM HOUSTON,TX 78234. RP ANDERS, GT (reprint author), BROOKE ARMY MED CTR,DEPT MED,PULM DIS CRIT CARE SERV,FT SAM HOUSTON,TX 78234, USA. NR 8 TC 6 Z9 6 U1 0 U2 0 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD DEC PY 1991 VL 144 IS 6 BP 1406 EP 1407 PG 2 WC Respiratory System SC Respiratory System GA GU988 UT WOS:A1991GU98800034 PM 1741557 ER PT J AU KINGSLEY, CP BAUMGARTEN, RK AF KINGSLEY, CP BAUMGARTEN, RK TI USE OF AN OXYGEN CONCENTRATOR LINKED TO A DRAWOVER VAPORIZER SO ANESTHESIA AND ANALGESIA LA English DT Letter C1 BROOKE ARMY MED CTR,ANESTHESIA & OPERAT SERV,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,DEPT SURG,FT SAM HOUSTON,TX 78234. RP KINGSLEY, CP (reprint author), BROOKE ARMY MED CTR,DEPT CLIN INVEST,FT SAM HOUSTON,TX 78234, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD DEC PY 1991 VL 73 IS 6 BP 826 EP 827 PG 2 WC Anesthesiology SC Anesthesiology GA GR648 UT WOS:A1991GR64800032 PM 1952190 ER PT J AU HOSKING, MP AF HOSKING, MP TI SHOULD CALCIUM BE ADMINISTERED PRIOR TO SEPARATION FROM CARDIOPULMONARY BYPASS SO ANESTHESIOLOGY LA English DT Letter ID INJURY RP HOSKING, MP (reprint author), BROOKE ARMY MED CTR,CARDIOVASC ANESTHESIA,FT SAM HOUSTON,TX 78234, USA. NR 6 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD DEC PY 1991 VL 75 IS 6 BP 1121 EP 1121 DI 10.1097/00000542-199112000-00030 PG 1 WC Anesthesiology SC Anesthesiology GA GV115 UT WOS:A1991GV11500030 PM 1741505 ER PT J AU DICE, WH AF DICE, WH TI THE ROLE OF MILITARY EMERGENCY PHYSICIANS IN AN ASSAULT OPERATION IN PANAMA SO ANNALS OF EMERGENCY MEDICINE LA English DT Article DE MILITARY EMERGENCY MEDICINE AB The December 1989 assault in Panama provided an opportunity to examine the role of emergency physicians in low-intensity military operations. Emergency medicine specialists accompanied the assault forces and established casualty collection points (CCPs) at each target. Emergency physicians played a role in triage, resuscitation, and aeromedical evacuation. More than 275 casualties were resuscitated and stabilized at the CCPs. Two died after reaching a CCP. Casualties were flown from each CCP to a joint casualty collection point (JCCP). Surgical stabilization was required for 21 casualties at the JCCP. A team at the JCCP coordinated evacuation of casualties to the United States. The first casualties arrived at hospitals in Texas within 12 hours of the assault. From the drop zones through hospitalization in the United States, emergency physicians cared for combat casualties at every level of the evacuation system. The success of the medical plan for the assault suggests that the role of emergency physicians in military operations extends from the front lines to fixed medical facilities in the United States. C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. NR 0 TC 8 Z9 8 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD DEC PY 1991 VL 20 IS 12 BP 1336 EP 1340 DI 10.1016/S0196-0644(05)81077-7 PG 5 WC Emergency Medicine SC Emergency Medicine GA GR823 UT WOS:A1991GR82300012 PM 1746738 ER PT J AU MOORE, DW DILLON, TM SUEDEL, BC AF MOORE, DW DILLON, TM SUEDEL, BC TI CHRONIC TOXICITY OF TRIBUTYLTIN TO THE MARINE POLYCHAETE WORM, NEANTHES-ARENACEODENTATA SO AQUATIC TOXICOLOGY LA English DT Article DE TRIBUTYLTIN EXPOSURE; NEANTHES-ARENACEODENTATA; TOXICITY ID CHESAPEAKE BAY; REPRODUCTION; GROWTH; ACCUMULATION; POPULATIONS; CADMIUM; MODES; MFO AB Life cycle toxicity tests provide ecologically relevant indices for estimating long-term 'safe' concentrations of environmental contaminants. Tissue concentrations observed in animals from these tests can also be used to estimate the risk associated with contaminant residues in field collected animals. Such residue-effects information was generated for the marine polychaete worm, Neanthes arenaceodentata, exposed to the organometal, tributyltin (TBT). Juvenile Neanthes were exposed in the laboratory to five concentrations (500, 100, 50, 10, 0 ng/l) of TBT. After ten weeks, effects on survival, growth and reproduction were evaluated. Significant mortality (79%) was observed only in the highest TBT exposure concentration. Growth (dry weights of individual worms) was significantly reduced in the two highest TBT treatments. Reproduction (mean number of eggs and emergent juvenile (EJ) worms) was significantly reduced in the 100 ng/l treatment. Reproduction was not evaluated in worms from the 500 ng/l treatment due to low survival and an inability to distinguish sexes. No adverse effect on survival, growth or reproduction was observed in worms exposed to 50 or 10 ng/l TBT. TBT had no observed effect on egg size, estimated individual EJ dry weight or timing of reproductive events. Neanthes arenaceodentata accumulated significant amounts of TBT which mirrored the exposure gradient; i.e. 16.81, 6.27, 2.99, 1.47 and 0.21-mu-g/g dry weight. Chronic effects were observed in worms with tissue concentrations > 6.3-mu-g TBT/g dry weight. No significant effects were observed at tissue concentrations < 3.0-mu-g/g. Detectable amounts of TBT metabolites (di- and monobutyltin) were found in all tissue samples with a greater proportion found in worms with lower TBT residues. These TBT residue data are discussed in relation to comparative laboratory and field information. C1 UNIV MISSISSIPPI,DEPT BIOL,UNIVERSITY,MS 38677. RP MOORE, DW (reprint author), USA,WATERWAYS EXPT STN,ENVIRONM LAB,VICKSBURG,MS 39180, USA. NR 52 TC 26 Z9 27 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-445X J9 AQUAT TOXICOL JI Aquat. Toxicol. PD DEC PY 1991 VL 21 IS 3-4 BP 181 EP 198 DI 10.1016/0166-445X(91)90072-H PG 18 WC Marine & Freshwater Biology; Toxicology SC Marine & Freshwater Biology; Toxicology GA HE061 UT WOS:A1991HE06100005 ER PT J AU SNOW, DM AF SNOW, DM TI HIGH TECHNOLOGY AND NATIONAL-SECURITY - A PRELIMINARY ASSESSMENT SO ARMED FORCES & SOCIETY LA English DT Article; Proceedings Paper CT BIENNIAL CONF OF THE INTER-UNIVERSITY SEMINAR OR ARMED FORCES AND SOCIETY CY OCT 29, 1989 CL BALTIMORE, MD AB This article argues that high technology, defined in terms of the explosion of information gathering and disseminating capability, is becoming a much more important component of national security. At one level, high technology is the driving force behind economic competitiveness and thus economic security. More specifically, five specific national security impact areas are examined: dual-use technologies and their impact on technology transfer; the international character of the technology process; the relationship between high technology and economic security; the effects of communications technology on crisis management; and the difficulty of maintaining national political control over technology dispersion. The article concludes that technology is changing so rapidly that it is increasingly difficult to keep up with its effects. RP SNOW, DM (reprint author), USA,WAR COLL,DEPT NATL SECUR & STRATEGY,CARLISLE,PA 17013, USA. NR 46 TC 0 Z9 0 U1 0 U2 0 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD WIN PY 1991 VL 17 IS 2 BP 243 EP 258 DI 10.1177/0095327X9101700205 PG 16 WC Political Science; Sociology SC Government & Law; Sociology GA HB508 UT WOS:A1991HB50800005 ER PT J AU GOUGH, TJ AF GOUGH, TJ TI ORIGINS OF THE ARMY-INDUSTRIAL-COLLEGE - MILITARY-BUSINESS TENSIONS AFTER WORLD-WAR-1 SO ARMED FORCES & SOCIETY LA English DT Article AB In founding the Army Industrial College in the 1920s, activist U.S. Army logistical officers were not wholeheartedly embracing closer relations with the business sector. World War I had demonstrated to them the need for the military to school itself in mobilizing for industrial-based war. But the war also had presented businessmen as rivals for control of procurement functions. With the knowledge acquired in their planned industrial college, the logistical officers hoped to gain an advantage over civilian dollar-a-year men in any future mobilization. They wanted to improve the Army's performance and simultaneously to achieve for themselves increased professional status and recognition in comparison with the combat arms officers who habitually reaped the lion's share of wartime glory. Seen from this perspective, pre-World War II military-industrial relations appear less close than generally thought and require fresh study. RP GOUGH, TJ (reprint author), USA,CTR MIL HIST,STAFF SUPPORT ACT,WASHINGTON,DC 20314, USA. NR 68 TC 3 Z9 3 U1 0 U2 2 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD WIN PY 1991 VL 17 IS 2 BP 259 EP 275 DI 10.1177/0095327X9101700206 PG 17 WC Political Science; Sociology SC Government & Law; Sociology GA HB508 UT WOS:A1991HB50800006 ER PT J AU YOUNG, TD AF YOUNG, TD TI WHITHER FUTURE UNITED-STATES ALLIANCE STRATEGY - THE ABCA CLUE SO ARMED FORCES & SOCIETY LA English DT Article AB This article describes and analyzes the little-known, but extensive, defense cooperative relationship that exists among the armed forces of the United States, Britain, Canada, Australia, and New Zealand. While perhaps arguably a relatively esoteric subject prior to 1989, given the recent changes that have taken place in the Soviet Union, U.S. alliance strategy is now on the threshold of a new era-an era in which the Soviet threat is seen by many allies as diminishing. As U.S. officials ponder the implications of a decreased Soviet threat on its many alliances, of which almost all have been threat-based, it will be important to recall the one series of collective security arrangements with allies that has been founded on similarities, vice solely threats. This intimate Anglo-Saxon connection appears to have the needed bases for enduring well into the post-cold-war era. RP YOUNG, TD (reprint author), USA,WAR COLL,INST STRATEG STUDIES,CARLISLE,PA 17013, USA. NR 41 TC 0 Z9 0 U1 0 U2 0 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD WIN PY 1991 VL 17 IS 2 BP 277 EP 297 DI 10.1177/0095327X9101700207 PG 21 WC Political Science; Sociology SC Government & Law; Sociology GA HB508 UT WOS:A1991HB50800007 ER PT J AU KRIGSMAN, HA AF KRIGSMAN, HA TI STATE SUPPORT OF INTERNATIONAL TERRORISM - LEGAL, POLITICAL, AND ECONOMIC DIMENSIONS - MURPHY,JF SO ARMED FORCES & SOCIETY LA English DT Book Review RP KRIGSMAN, HA (reprint author), US MIL ACAD,DEPT SOCIAL SCI,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD WIN PY 1991 VL 17 IS 2 BP 307 EP 309 DI 10.1177/0095327X9101700211 PG 3 WC Political Science; Sociology SC Government & Law; Sociology GA HB508 UT WOS:A1991HB50800011 ER PT J AU BURKE, TJ AF BURKE, TJ TI ESTIMATE OF REQUIREMENTS FOR DETECTION AND TREATMENT OF HYPERCHOLESTEROLEMIA IN UNITED-STATES-ARMY AVIATORS SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article AB In May 1988, the Army Surgeon General issued guidelines and a preliminary plan for evaluation and treatment of hypercholesterolemia, based on the recommendations of the National Cholesterol Education Program Expert Panel. Implementation of this plan in the aviation population would require an unknown number of aviators to undergo testing and possibly therapy for hypercholesterolemia. This study uses a mathematical model and information from the Aviation Epidemiology Data Register to estimate the number of aviators who would require detailed lipoprotein analysis and at least dietary therapy, based on evaluation of their total serum cholesterol and other coronary artery disease (CAD) risk factors, as described in the expert panel report. The model predicts that at least 27% of all aviators would require LDL screening, and 24.6% of all aviators would require dietary or drug therapy. C1 USA,AEROMED RES LAB,DIV BIOMED APPL,FT RUCKER,AL 36360. NR 5 TC 0 Z9 0 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD DEC PY 1991 VL 62 IS 12 BP 1174 EP 1179 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA GR868 UT WOS:A1991GR86800010 PM 1755800 ER PT J AU TANDON, NN OCKENHOUSE, CF GRECO, NJ JAMIESON, GA AF TANDON, NN OCKENHOUSE, CF GRECO, NJ JAMIESON, GA TI ADHESIVE FUNCTIONS OF PLATELETS LACKING GLYCOPROTEIN-IV (CD36) SO BLOOD LA English DT Note ID MEMBRANE GLYCOPROTEIN; MONOCLONAL-ANTIBODY; SURFACE EXPRESSION; THROMBOSPONDIN; RECEPTOR; AGGREGATION; IDENTIFICATION; CYTOADHERENCE; ERYTHROCYTES; MONOCYTE C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP TANDON, NN (reprint author), AMER RED CROSS,CELL BIOL LAB,15601 CRABBS BRANCH WAY,ROCKVILLE,MD 20855, USA. FU NHLBI NIH HHS [HL-40858] NR 26 TC 81 Z9 81 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD DEC 1 PY 1991 VL 78 IS 11 BP 2809 EP 2813 PG 5 WC Hematology SC Hematology GA GR781 UT WOS:A1991GR78100002 PM 1720035 ER PT J AU CALKINS, DJ AF CALKINS, DJ TI LONGITUDINAL FLOATING STRUCTURES - NEW CONCEPTS IN RIVER ICE CONTROL SO CANADIAN JOURNAL OF CIVIL ENGINEERING LA English DT Article DE RIVER ICE; ICE JAMS; ICE CONTROL; HYDRAULIC STRUCTURES; ICE BOOMS AB Ice control structures placed in the streamwise direction of a river were analyzed to determine the effectiveness in reducing, ice jam thicknesses. The theory describing the thickness for "wide" river ice jams was modified to analyze these longitudinal types, providing the computational verification that ice jam thicknesses could be reduced where the mode of ice cover thickening is internal collapse. These longitudinal structures appear to provide a new tool for modifying the river ice regime at freeze-up and possibly at breakup. By decreasing the ice jam thicknesses, which leads to lower stages, the structures have the potential for decreasing ice jam flood levels. The structures' ability to function is independent of the flow velocity and these structures should perform in rivers with velocities greater than the usual limitation of roughly 1 m/s associated with conventional cross-channel ice booms. Other possible applications include controlling ice movement at outlets from lakes, enhancing river ice cover progression, or even restraining the ice cover at breakup. A U.S. patent application has been filed jointly by the author and the U.S. Army Corps of Engineers. RP CALKINS, DJ (reprint author), USA,COLD REG RES & ENGN LAB,GEOL SCI BRANCH,HANOVER,NH 03755, USA. NR 14 TC 1 Z9 1 U1 0 U2 0 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A 0R6, CANADA SN 0315-1468 J9 CAN J CIVIL ENG JI Can. J. Civ. Eng. PD DEC PY 1991 VL 18 IS 6 BP 933 EP 939 PG 7 WC Engineering, Civil SC Engineering GA HF504 UT WOS:A1991HF50400005 ER PT J AU VESILIND, PA WALLINMAA, S MARTEL, CJ AF VESILIND, PA WALLINMAA, S MARTEL, CJ TI FREEZE-THAW SLUDGE CONDITIONING AND DOUBLE-LAYER COMPRESSION SO CANADIAN JOURNAL OF CIVIL ENGINEERING LA English DT Article DE SLUDGE; FREEZING; COAGULATION; DEWATERING AB Freeze - thaw conditioning of water and wastewater sludges is known to be an effective and economical means of promoting dewatering when natural freezing is employed. When sludge freezes, both the suspended and dissolved solids are rejected by the growing ice front. Particles trapped in ice are known to have a very thin layer of water surrounding them and this water does not freeze at normal temperatures. Dissolved solids are thought to accumulate in this layer, causing an increase in the ionic strength of the water. This may cause compression of the double layer, leading to neutralization of repulsive forces, thus promoting aggregation. In order to test this hypothesis, ionic strength was increased by adding sodium chloride (NaCl) to water and wastewater sludges and measuring dewaterability (filtration) with the capillary suction time (CST) apparatus. Four different kinds of sludge were used: alum sludge (water treatment), waste-activated sludge, simultaneous precipitation, and anaerobically digested mixed sludge. Salinities of 0-20 000 mg/L as NaCl were tested with every sludge. No enhancement in dewaterability with freeze - thawed sludges of raised ionic strength compared to zero salinity was recorded, therefore the hypothesis of double layer compression being a major factor in freeze - thaw conditioning does not seem to be correct. C1 TAMPERE UNIV,INST WATER & ENVIRONM ENGN,SF-33101 TAMPERE 10,FINLAND. USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. RP VESILIND, PA (reprint author), DUKE UNIV,DEPT CIVIL & ENVIRONM ENGN,DURHAM,NC 27706, USA. NR 11 TC 35 Z9 35 U1 0 U2 5 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A 0R6, CANADA SN 0315-1468 J9 CAN J CIVIL ENG JI Can. J. Civ. Eng. PD DEC PY 1991 VL 18 IS 6 BP 1078 EP 1083 PG 6 WC Engineering, Civil SC Engineering GA HF504 UT WOS:A1991HF50400020 ER PT J AU WEINER, M LEVENTHAL, B CANTOR, A WIMMER, R BERRY, DL COOK, B DUCOS, R AF WEINER, M LEVENTHAL, B CANTOR, A WIMMER, R BERRY, DL COOK, B DUCOS, R TI GA-67 SCANS AS AN ADJUNCT TO COMPUTED-TOMOGRAPHY SCANS FOR THE ASSESSMENT OF A RESIDUAL MEDIASTINAL MASS IN PEDIATRIC-PATIENTS WITH HODGKINS-DISEASE - A PEDIATRIC ONCOLOGY GROUP-STUDY SO CANCER LA English DT Article ID GA-67; LYMPHOMA; CHEMOTHERAPY AB This study determines the utility of gallium-67 (Ga-67) scintigraphs as an adjunct to computed tomography (CT) scans for the assessment of residual mediastinal masses in children and adolescents with advanced-stage Hodgkin's disease. At diagnosis 42 patients with CT scan-documented mediastinal disease had a Ga-67 scan performed. Thirty-four of 42 patients (81%) had gallium-avid mediastinal lesions, whereas in eight (19%), the Ga-67 scan was negative. At the completion of eight cycles of therapy of Mustargen (mechlorethamine), Oncovin (vincristine), procarbazine, prednisone (MOPP) alternating with doxorubicin, bleomycin, vinblastine, dacarbazine (ABVD), 21 of 34 patients with initially positive Ga-67 scans had them repeated; 18 of 21 converted to negative results, and three remained positive. In 11 of 18 patients, the loss of gallium avidity was consistent with a negative mediastinal CT scan. In seven, although the gallium scan was negative, the CT scan remained positive; all seven patients had a mediastinal biopsy of suspected residual disease and in alt seven the biopsy results were negative for Hodgkin's disease. These preliminary results in a small cohort of patients demonstrate that Ga-67 scans may be of benefit in evaluating residual mediastinal masses in patients with Hodgkin's disease. C1 HACKENSACK MED CTR,HACKENSACK,NJ. CHILDRENS HOSP NEW ORLEANS,NEW ORLEANS,LA. JOHNS HOPKINS UNIV,BALTIMORE,MD 21218. UNIV FLORIDA,GAINESVILLE,FL 32611. ST CHRISTOPHERS HOSP CHILDREN,PHILADELPHIA,PA 19133. UNIV ARKANSAS,FAYETTEVILLE,AR 72701. TRIPLER ARMY MED CTR,HONOLULU,HI 96859. FU NCI NIH HHS [CA-29139, CA-30960, CA-28476] NR 16 TC 39 Z9 39 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD DEC 1 PY 1991 VL 68 IS 11 BP 2478 EP 2480 DI 10.1002/1097-0142(19911201)68:11<2478::AID-CNCR2820681126>3.0.CO;2-3 PG 3 WC Oncology SC Oncology GA GQ105 UT WOS:A1991GQ10500025 PM 1933785 ER PT J AU TONEY, MO HEIRONIMUS, JD AF TONEY, MO HEIRONIMUS, JD TI FAMILIAL DYSALBUMINEMIC HYPERTHYROXINEMIA ASSOCIATED WITH MULTINODULAR GOITER AND ELEVATED RADIOIODINE UPTAKE - A CASE-REPORT SO CLINICAL NUCLEAR MEDICINE LA English DT Article ID THYROXINE-BINDING; EXCESS AB Familial dysalbumenic hyperthyroxenemia characterized by elevations in serum total thyroxine (T4) and free-thyroxine index and normal free T4 and radioiodine uptake has been previously described. This syndrome is secondary to an autosomal dominant inheritance in which affected individuals are mistakenly diagnosed as thyrotoxic because of the elevation of serum levels of total T4 and free T4. The excess T4 level is caused by the presence of an abnormal serum protein that binds excess T4, thereby raising the level of total T4. The authors report the case of a patient with familial dysalbumenic hyperthyroxenemia who presented with superimposed multinodular goiter and an elevated 24-hour radioiodide uptake. C1 BROOKE ARMY MED CTR,DEPT RADIOL,NUCL MED SERV,FT SAM HOUSTON,TX 78234. NR 4 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD DEC PY 1991 VL 16 IS 12 BP 926 EP 927 DI 10.1097/00003072-199112000-00010 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA KC609 UT WOS:A1991KC60900010 PM 1769174 ER PT J AU BERMAN, JD FLECKENSTEIN, L AF BERMAN, JD FLECKENSTEIN, L TI PHARMACOKINETIC JUSTIFICATION OF ANTIPROTOZOAL THERAPY - A UNITED-STATES PERSPECTIVE SO CLINICAL PHARMACOKINETICS LA English DT Article ID PNEUMOCYSTIS-CARINII PNEUMONIA; LIPID-SOLUBLE ANTIFOLATE; CLINICAL PHARMACOKINETICS; SODIUM STIBOGLUCONATE; SLEEPING SICKNESS; AMPHOTERICIN-B; PENTAMIDINE; POTENT; ANTIMONY; KINETICS AB Infections with parasitic protozoa have always been problems for the developing world and are becoming of greater importance to the developed world in this age of easy international travel. The major human protozoal diseases are summarised with an emphasis on their presentation in normal hosts and in immunocompromised individuals and current US drug treatment recommendations are discussed. Present antiprotozoal regimens are based either on a pharmacokinetic rationale or on clinical trial and error. Regimens based on trial and error include amphotericin B against leishmaniasis and arsenic against African trypanosomiasis. Regimens which are to some extent driven by pharmacokinetic or biochemical considerations include paromomycin and metronidazole against amoebiasis, sodium stibogluconate against leishmaniasis, halofantrine and mefloquine against malaria, dihydrofolate reductase (DHFR) inhibitors against Pneumocystis carinii and toxoplasmosis and aerosolised pentamidine against P. carinii pneumonia. The majority of pharmacokinetic studies have been performed only on agents which have some therapeutic activity against other diseases of the developed world. Despite the trend toward rational treatment regimens, no studies have been per-formed that permit optimisation of antiprotozoal treatment regimens on the basis of clinical conditions such as renal failure. RP BERMAN, JD (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307, USA. NR 34 TC 13 Z9 14 U1 0 U2 0 PU ADIS INTERNATIONAL LTD PI AUCKLAND PA 41 CENTORIAN DR, PRIVATE BAG 65901, MAIRANGI BAY, AUCKLAND 10, NEW ZEALAND SN 0312-5963 J9 CLIN PHARMACOKINET JI Clin. Pharmacokinet. PD DEC PY 1991 VL 21 IS 6 BP 479 EP 493 DI 10.2165/00003088-199121060-00007 PG 15 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA GT381 UT WOS:A1991GT38100006 PM 1782741 ER PT J AU ADAMS, JG COLEMAN, MB STEINBERG, MH WALKER, AM PLONCZYNSKI, MW HARRELL, AH KARK, JA SCHECHTER, GP AF ADAMS, JG COLEMAN, MB STEINBERG, MH WALKER, AM PLONCZYNSKI, MW HARRELL, AH KARK, JA SCHECHTER, GP TI A NEW CASE OF HB SAN-DIEGO IN AN IRANIAN INDIVIDUAL - EVIDENCE FOR AN INCREASE IN THE MUTATION-RATE OF C-]T TRANSITIONS IN CPG DINUCLEOTIDES SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 VET ADM MED CTR,JACKSON,MS 39216. UNIV MISSISSIPPI,MED CTR,SCH MED,DEPT MED,JACKSON,MS 39216. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. VET ADM MED CTR,WASHINGTON,DC 20422. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD DEC PY 1991 VL 39 IS 4 BP A840 EP A840 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA GW912 UT WOS:A1991GW91200245 ER PT J AU CURTIS, J ONEILL, JT PAYNE, AM PETTETT, G AF CURTIS, J ONEILL, JT PAYNE, AM PETTETT, G TI COMPARISON OF INTRAVENOUS AND ENDOTRACHEAL TOLAZOLINE SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD DEC PY 1991 VL 39 IS 4 BP A865 EP A865 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA GW912 UT WOS:A1991GW91200381 ER PT J AU ZIMMERMAN, PA POTH, M AF ZIMMERMAN, PA POTH, M TI HAIR PRODUCTS - A CAUSE OF PRECOCIOUS PSEUDOPUBERTY SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD DEC PY 1991 VL 39 IS 4 BP A881 EP A881 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA GW912 UT WOS:A1991GW91200457 ER PT J AU LARSON, M KRAUS, NC AF LARSON, M KRAUS, NC TI MATHEMATICAL-MODELING OF THE FATE OF BEACH FILL SO COASTAL ENGINEERING LA English DT Article AB This paper describes mathematical approaches for calculating the fate of beach fill under wave action. General properties of the spatial and temporal behavior of fills under average longshore sand transport conditions are first reviewed through use of simple closed-form solutions of the sediment continuity equation. This well-known solution procedure is then extended to describe the collective movement of sediment or "longshore sand waves". Because of the increasing use of beach fills as storm-protection barriers, the paper focuses on prediction of storm-induced beach erosion. An empirically based model is described and tested with a high-quality field data set of storm-induced beach erosion. One synthetic tropical storm and one synthetic extratropical storm representing typical mid-Atlantic storms with approximate 2-5-year return period are then used to simulate the erosion of two hypothetical beach fill configurations and the subsequent post-storm recovery process. Eroded volume and contour movement are evaluated as a function of storm type, fill cross section, grain size, and time. Quantitative and qualitative features of storm erosion are reasonably well reproduced, and calculated changes in beach fills impacted by the synthetic storms indicate that little erosion protection benefit is gained for moderate storms (2-5-year return period) by placing fills with grain sizes greater than 0.4 mm. Simulation of post-storm beach recovery is presently limited to qualitative reproduction of observed trends. C1 USA,COASTAL ENGN RES CTR,ENGINEER WATERWAYS EXPT STN,VICKSBURG,MS 39180. RP LARSON, M (reprint author), UNIV LUND,INST SCI & TECHNOL,DEPT WATER RESOURCES ENGN,BOX 118,S-22100 LUND,SWEDEN. NR 48 TC 25 Z9 25 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3839 J9 COAST ENG JI Coast. Eng. PD DEC PY 1991 VL 16 IS 1 BP 83 EP 114 DI 10.1016/0378-3839(91)90054-K PG 32 WC Engineering, Civil; Engineering, Ocean SC Engineering GA HB675 UT WOS:A1991HB67500006 ER PT J AU BLAUER, KL POTH, M ROGERS, WM BERNTON, EW AF BLAUER, KL POTH, M ROGERS, WM BERNTON, EW TI DEHYDROEPIANDROSTERONE ANTAGONIZES THE SUPPRESSIVE EFFECTS OF DEXAMETHASONE ON LYMPHOCYTE-PROLIFERATION SO ENDOCRINOLOGY LA English DT Article ID LYMPHOKINE PRODUCTION INVIVO; T-CELLS; SERUM; ESTROGEN; SULFATE; CANCER; HELPER; DHEA; MICE; CORTICOSTEROIDS AB Administration of dehydroepiandrosterone (DHEA) appears to have physiological effects opposing those of glucocorticoids in several animal models. Recently, immunomodulatory effects of treatment with DHEA have been described. This paper reports the effects of DHEA treatment on splenocyte blastogenic responses as well as thymic and spleen weights in (CH)-H-3/HeN mice. Pretreatment of mice with sc DHEA (60 mg/kg.day) for 3 days in vivo antagonized the profound suppression of in vitro blastogenic responses seen in T- and B-lymphocytes after a single injection of dexamethasone (DEX; 60 mg/kg). Pretreatment with DHEA also significantly reduced dexamethasone-induced thymic and splenic atrophy. Splenic lymphocytes from DHEA-treated mice were markedly more resistant to in vitro suppression of blastogenesis by DEX at 10(-6)-10(-8) M compared to lymphocytes from control mice. However, DHEA added to lymphocyte cultures in vitro over a concentration range from 10(-7)-10(-8) M failed to protect against suppression of mitogenic responses caused by addition of DEX to cultures. In summary, DHEA given in vivo antagonizes the suppressive actions of DEX on lymphoid target tissues in mice. C1 WALTER REED ARMY MED CTR,DIV REPROD ENDOCRINOL,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT PEDIAT,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307. RP BLAUER, KL (reprint author), USAF,MED CTR,DEPT OBSTET & GYNECOL,DIV REPROD ENDOCRINOL,WRIGHT PATTERSON AFB,OH 45433, USA. NR 38 TC 190 Z9 193 U1 0 U2 7 PU ENDOCRINE SOC PI BETHESDA PA 4350 EAST WEST HIGHWAY SUITE 500, BETHESDA, MD 20814-4110 SN 0013-7227 J9 ENDOCRINOLOGY JI Endocrinology PD DEC PY 1991 VL 129 IS 6 BP 3174 EP 3179 PG 6 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA GT670 UT WOS:A1991GT67000048 PM 1835439 ER PT J AU FOX, AM HALLER, WT GETSINGER, KD AF FOX, AM HALLER, WT GETSINGER, KD TI FACTORS THAT INFLUENCE WATER EXCHANGE IN SPRING-FED TIDAL CANALS SO ESTUARIES LA English DT Article AB Environmental factors that influenced the rates of water exchange in a series of tidal, dead-end canals in Crystal River, Florida, were investigated by measuring the rates of dilution of the fluorescent dye Rhodamine WT. Water temperature regime was the most influential of these factors, with type of tidal cycle (spring or neap) and density of submersed vegetation (dominated by Hydrilla verticillata) only affecting dye dilution rates in winter treatments. Dye half-lives were shortest in the summer (12-24 h), longest in the fall and spring (60-120 h), and most sensitive to water temperature patterns in the winter (26-60 h). These data provide useful information relating to the timing of hydrilla management using aquatic herbicides in spring-fed tidal systems. A mechanism is proposed that relates the canal water temperatures to tidal water movement and outputs from the adjacent Three Sisters Springs. C1 USA,WATERWAYS EXPT STN,ENVIRONM LAB,VICKSBURG,MS 39180. UNIV FLORIDA,INST FOOD & AGR SCI,DEPT AGRON,GAINESVILLE,FL 32606. RP FOX, AM (reprint author), UNIV FLORIDA,INST FOOD & AGR SCI,CTR AQUAT PLANTS,7922 NW 71ST ST,GAINESVILLE,FL 32606, USA. NR 16 TC 9 Z9 9 U1 0 U2 2 PU ESTUARINE RES FEDERATION PI LAWRENCE PA PO BOX 368, LAWRENCE, KS 66044 SN 0160-8347 J9 ESTUARIES JI Estuaries PD DEC PY 1991 VL 14 IS 4 BP 404 EP 413 DI 10.2307/1352265 PG 10 WC Environmental Sciences; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA HE405 UT WOS:A1991HE40500006 ER PT J AU HO, H TSAI, MY MORTON, J FARLEY, GL AF HO, H TSAI, MY MORTON, J FARLEY, GL TI AN EXPERIMENTAL INVESTIGATION OF IOSIPESCU SPECIMEN FOR COMPOSITE-MATERIALS SO EXPERIMENTAL MECHANICS LA English DT Article ID SHEAR TEST AB A detailed experimental evaluation of the losipescu specimen tested in the modified Wyoming fixture is presented. Moire interferometry is employed to determine the deformation of unidirectional and cross-ply graphite-epoxy specimens. The results of the moire experiments are compared to those from the traditional strain-gage method. It is shown that the strain-gage readings from one surface of a specimen together with corresponding data from moire interferometry on the opposite face documented an extreme sensitivity of some fiber orientations to twisting. A localized hybrid analysis is introduced to perform efficient reduction of moire data, producing whole-field strain distributions in the specimen test sections. C1 USA,AEROSTRUCT DIRECTORATE,NASA,LANGLEY RES CTR,HAMPTON,VA 23665. RP HO, H (reprint author), VIRGINIA POLYTECH INST & STATE UNIV,DEPT ENGN SCI & MECH,BLACKSBURG,VA 24061, USA. NR 18 TC 26 Z9 26 U1 0 U2 1 PU SOC EXPERIMENTAL MECHANICS PI BETHEL PA 7 SCHOOL STREET, BETHEL, CT 06801 SN 0014-4851 J9 EXP MECH JI Exp. Mech. PD DEC PY 1991 VL 31 IS 4 BP 328 EP 336 DI 10.1007/BF02325989 PG 9 WC Materials Science, Multidisciplinary; Mechanics; Materials Science, Characterization & Testing SC Materials Science; Mechanics GA GY819 UT WOS:A1991GY81900006 ER PT J AU UNDERWOOD, JH BARATTA, FI ZALINKA, JJ AF UNDERWOOD, JH BARATTA, FI ZALINKA, JJ TI FRACTURE-TOUGHNESS TESTS AND DISPLACEMENT AND CRACK-STABILITY ANALYSES OF TUNGSTEN ROUND BEND SPECIMENS SO EXPERIMENTAL MECHANICS LA English DT Article ID INTENSITY AB Plane-strain fracture-toughness tests were performed using the recently proposed round-bar bend test procedure with a liquid-phase sintered tungsten alloy. The tests included a direct comparison of fracture toughness from rectangular and round-bend specimens and measurements of load-line compliance using the unloading technique of J-integral fracture tests. Complementary displacement and crack-growth stability analyses of the round bar were performed as an extension of recent work in these two areas. C1 USA,MAT TECHNOL LAB,WATERTOWN,MA 02172. RP UNDERWOOD, JH (reprint author), USA,CTR RD&E,WATERVLIET,NY 12189, USA. NR 14 TC 5 Z9 5 U1 0 U2 0 PU SOC EXPERIMENTAL MECHANICS PI BETHEL PA 7 SCHOOL STREET, BETHEL, CT 06801 SN 0014-4851 J9 EXP MECH JI Exp. Mech. PD DEC PY 1991 VL 31 IS 4 BP 353 EP 359 DI 10.1007/BF02325993 PG 7 WC Materials Science, Multidisciplinary; Mechanics; Materials Science, Characterization & Testing SC Materials Science; Mechanics GA GY819 UT WOS:A1991GY81900010 ER PT J AU DACHMAN, AH LEVINE, MS AF DACHMAN, AH LEVINE, MS TI RADIOLOGY OF THE ESOPHAGUS SO GASTROENTEROLOGY CLINICS OF NORTH AMERICA LA English DT Article ID DOUBLE-CONTRAST ESOPHAGOGRAPHY; COMPUTED-TOMOGRAPHY; INTRAMURAL PSEUDODIVERTICULOSIS; RADIOGRAPHIC DIAGNOSIS; REFLUX ESOPHAGITIS; BARRETTS ESOPHAGUS; CARCINOMA; FEATURES; AIDS; REEVALUATION C1 UNIFORMED SERV UNIV HLTH SCI,SCH MED,DEPT PHYS,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,ABDOMINAL RADIOL,WASHINGTON,DC 20307. HOSP UNIV PENN,GASTROINTESTINAL RADIOL SECT,PHILADELPHIA,PA 19104. UNIV PENN,SCH MED,PHILADELPHIA,PA 19104. RP DACHMAN, AH (reprint author), UNIFORMED SERV UNIV HLTH SCI,SCH MED,DEPT RADIOL,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. NR 58 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0889-8553 J9 GASTROENTEROL CLIN N JI Gastroenterol. Clin. North Am. PD DEC PY 1991 VL 20 IS 4 BP 635 EP 658 PG 24 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA GP849 UT WOS:A1991GP84900002 PM 1787006 ER PT J AU SHAY, SS AF SHAY, SS TI BENIGN STRUCTURAL LESIONS OF THE ESOPHAGUS SO GASTROENTEROLOGY CLINICS OF NORTH AMERICA LA English DT Review ID MALLORY-WEISS SYNDROME; UPPER GASTROINTESTINAL HEMORRHAGE; RIGHT SUBCLAVIAN ARTERY; INTRAMURAL PSEUDODIVERTICULOSIS; SPONTANEOUS PERFORATION; CERVICAL OSTEOPHYTES; DYSPHAGIA LUSORIA; GASTRIC-MUCOSA; INLET PATCH; MANAGEMENT C1 UNIFORMED SERV UNIV HLTH SCI,DEPT MED,DIV DIGEST DIS,BETHESDA,MD 20814. RP SHAY, SS (reprint author), WALTER REED ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,WASHINGTON,DC 20307, USA. NR 124 TC 3 Z9 3 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0889-8553 J9 GASTROENTEROL CLIN N JI Gastroenterol. Clin. North Am. PD DEC PY 1991 VL 20 IS 4 BP 673 EP 690 PG 18 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA GP849 UT WOS:A1991GP84900004 PM 1787009 ER PT J AU MOSES, FM AF MOSES, FM TI SQUAMOUS-CELL CARCINOMA OF THE ESOPHAGUS - NATURAL-HISTORY, INCIDENCE, ETIOLOGY, AND COMPLICATIONS SO GASTROENTEROLOGY CLINICS OF NORTH AMERICA LA English DT Article ID HIGH-RISK POPULATION; ORAL CAVITY; HUMAN PAPILLOMAVIRUS; PRECURSOR LESIONS; GASTRIC CARDIA; MATE DRINKING; CANCER; ALCOHOL; TOBACCO; CHINA C1 WALTER REED ARMY MED CTR,GASTROENTEROL SERV,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 88 TC 17 Z9 17 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0889-8553 J9 GASTROENTEROL CLIN N JI Gastroenterol. Clin. North Am. PD DEC PY 1991 VL 20 IS 4 BP 703 EP 716 PG 14 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA GP849 UT WOS:A1991GP84900006 PM 1787011 ER PT J AU DIEHL, LF AF DIEHL, LF TI RADIATION AND CHEMOTHERAPY IN THE TREATMENT OF ESOPHAGEAL CANCER SO GASTROENTEROLOGY CLINICS OF NORTH AMERICA LA English DT Article ID SQUAMOUS-CELL CARCINOMA; SOUTHWEST ONCOLOGY GROUP; PREOPERATIVE CHEMOTHERAPY; MITOGUAZONE CHEMOTHERAPY; THERAPY; CISPLATIN; RADIOTHERAPY; BLEOMYCIN; VINDESINE; ADENOCARCINOMA RP DIEHL, LF (reprint author), WALTER REED ARMY MED CTR,DEPT MED,HEMATOL ONCOL CLIN,WASHINGTON,DC 20307, USA. NR 37 TC 12 Z9 12 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0889-8553 J9 GASTROENTEROL CLIN N JI Gastroenterol. Clin. North Am. PD DEC PY 1991 VL 20 IS 4 BP 765 EP 774 PG 10 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA GP849 UT WOS:A1991GP84900010 PM 1787012 ER PT J AU PHILLIPS, RW WONG, RKH AF PHILLIPS, RW WONG, RKH TI BARRETTS-ESOPHAGUS - NATURAL-HISTORY, INCIDENCE, ETIOLOGY, AND COMPLICATIONS SO GASTROENTEROLOGY CLINICS OF NORTH AMERICA LA English DT Review ID COLUMNAR-LINED ESOPHAGUS; GASTROESOPHAGEAL REFLUX DISEASE; DUODENOGASTRIC REFLUX; CAMPYLOBACTER-PYLORI; CELL-PROLIFERATION; PEPTIC ESOPHAGITIS; SURGICAL-TREATMENT; RETICULAR PATTERN; DISTAL ESOPHAGUS; INLET PATCH C1 UNIFORMED SERV UNIV HLTH SCI, MED, BETHESDA, MD 20814 USA. RP WALTER REED ARMY MED CTR, GASTROENTEROL SERV, WASHINGTON, DC 20307 USA. NR 172 TC 115 Z9 118 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0889-8553 EI 1558-1942 J9 GASTROENTEROL CLIN N JI Gastroenterol. Clin. North Am. PD DEC PY 1991 VL 20 IS 4 BP 791 EP 876 PG 86 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA GP849 UT WOS:A1991GP84900012 PM 1787014 ER PT J AU KIKENDALL, JW AF KIKENDALL, JW TI PILL-INDUCED ESOPHAGEAL INJURY SO GASTROENTEROLOGY CLINICS OF NORTH AMERICA LA English DT Article ID DRUG-INDUCED ESOPHAGITIS; LEFT ATRIAL ENLARGEMENT; SLOW-RELEASE POTASSIUM; EMEPRONIUM BROMIDE; ULCERATION; TABLETS; DOXYCYCLINE; INGESTION; OBSTRUCTION; DOXICYCLINE RP KIKENDALL, JW (reprint author), WALTER REED ARMY MED CTR,GASTROENTEROL SERV,WASHINGTON,DC 20307, USA. NR 87 TC 34 Z9 34 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0889-8553 J9 GASTROENTEROL CLIN N JI Gastroenterol. Clin. North Am. PD DEC PY 1991 VL 20 IS 4 BP 835 EP 846 PG 12 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA GP849 UT WOS:A1991GP84900014 PM 1787016 ER PT J AU KIKENDALL, JW AF KIKENDALL, JW TI CAUSTIC INGESTION INJURIES SO GASTROENTEROLOGY CLINICS OF NORTH AMERICA LA English DT Review ID AUTOMATIC DISHWASHING DETERGENTS; CORROSIVE ESOPHAGEAL INJURIES; UPPER GASTROINTESTINAL-TRACT; LYE STRICTURES; BURNS; CHILDREN; STENT; PH RP KIKENDALL, JW (reprint author), WALTER REED ARMY MED CTR,GASTROENTEROL SERV,WASHINGTON,DC 20307, USA. NR 31 TC 47 Z9 50 U1 2 U2 2 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0889-8553 J9 GASTROENTEROL CLIN N JI Gastroenterol. Clin. North Am. PD DEC PY 1991 VL 20 IS 4 BP 847 EP 857 PG 11 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA GP849 UT WOS:A1991GP84900015 PM 1787017 ER PT J AU TRUESDALE, RA WONG, RKH AF TRUESDALE, RA WONG, RKH TI COMPLICATIONS OF ESOPHAGEAL VARICEAL SCLEROTHERAPY SO GASTROENTEROLOGY CLINICS OF NORTH AMERICA LA English DT Note ID ENDOSCOPIC INJECTION SCLEROTHERAPY; RANDOMIZED CONTROLLED TRIAL; BLEEDING VARICES; VENOUS THROMBOSIS; SCLEROSIS; PERFORATION; BACTEREMIA; PREVENTION; STRICTURES; HEMORRHAGE C1 WALTER REED ARMY MED CTR,GASTROENTEROL SERV,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,MED,BETHESDA,MD 20814. NR 108 TC 20 Z9 20 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0889-8553 J9 GASTROENTEROL CLIN N JI Gastroenterol. Clin. North Am. PD DEC PY 1991 VL 20 IS 4 BP 859 EP 870 PG 12 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA GP849 UT WOS:A1991GP84900016 PM 1787018 ER PT J AU WONG, RKH AF WONG, RKH TI MUCOSAL DISEASES OF THE ESOPHAGUS - PREFACE SO GASTROENTEROLOGY CLINICS OF NORTH AMERICA LA English DT Editorial Material RP WONG, RKH (reprint author), WALTER REED ARMY MED CTR,GASTROENTEROL SERV,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0889-8553 J9 GASTROENTEROL CLIN N JI Gastroenterol. Clin. North Am. PD DEC PY 1991 VL 20 IS 4 BP R9 EP R9 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA GP849 UT WOS:A1991GP84900001 ER PT J AU EGAN, WG HOGAN, AW ZHU, H AF EGAN, WG HOGAN, AW ZHU, H TI PHYSICAL VARIATION OF WATER-VAPOR, AND THE RELATION WITH CARBON-DIOXIDE SO GEOPHYSICAL RESEARCH LETTERS LA English DT Article ID ATMOSPHERIC TRACE GAS; PRECIPITATION; ANTARCTICA; TRANSPORT AB Analysis of the long term NOAA carbon dioxide flask sample records to examine the exchange among the continental Antarctic air mass and other air masses shows a meteorological variation of carbon dioxide concentration. There is an inverse relation between the seasonal variation of carbon dioxide concentration and water vapor at all stations examined. Well established diffusion coefficients indicate an interaction of water and carbon dioxide vapor on the molecular scale. Laboratory experiments using a Fourier transform spectrometer show carbon dioxide to be removed from an airstream in proportion to water vapor precipitated. We propose that interaction of carbon dioxide and water vapor in the atmosphere provides temporary sinks that can influence the balance of the carbon dioxide budget. C1 USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. CUNY CITY COLL,DEPT CHEM,NEW YORK,NY 10031. RP EGAN, WG (reprint author), CUNY YORK COLL,DEPT NAT SCI,JAMAICA,NY 11451, USA. NR 30 TC 2 Z9 3 U1 0 U2 0 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0094-8276 J9 GEOPHYS RES LETT JI Geophys. Res. Lett. PD DEC PY 1991 VL 18 IS 12 BP 2245 EP 2248 DI 10.1029/91GL02770 PG 4 WC Geosciences, Multidisciplinary SC Geology GA GY093 UT WOS:A1991GY09300018 ER PT J AU LIU, GM KOVACS, A BECKER, A AF LIU, GM KOVACS, A BECKER, A TI INVERSION OF AIRBORNE ELECTROMAGNETIC SURVEY DATA FOR SEA-ICE KEEL SHAPE SO GEOPHYSICS LA English DT Article ID THICKNESS; SYSTEM AB It is possible to interpret conventional airborne electromagnetic (EM) data acquired over ice-covered Arctic seas to obtain values of the sea ice thickness and, where needed, the actual sea ice keel geometry. To do so, we require high-frequency (inductive limit) data that allows us to assume that the ice is virtually transparent to the EM fields while the sea water forms a perfect conductor. Practically, a 100 kHz operating frequency is needed, but data acquired at a lower frequency can be scaled to obtain the required inductive limit anomaly. The data inversion is done by linking Occam's inversion method to a rapid numerical, two-dimensional, forward solution for the ice keel problem. A most useful feature of the adopted inversion scheme is the minimization of the roughness or the mean square slope of the keel boundary. In some cases, where the keel might be bounded by steeply dipping walls, this constraint may result in a less accurate solution than might be obtained with a conventional technique. In most cases the advantage in stability that it provides outweighs the possible loss of accuracy that it may occasion. Tests on synthetic data show a possible worst case ice thickness error of about 15 percent. The results of inversion tests for two sets of survey data acquired near Prudhoe Bay, Alaska, also indicate an accuracy of this order of magnitude. While some portion of the inversion error must be ascribed to the roughness constraint and is therefore inherent to the inversion technique used, the remainder must be ascribed to the instrumentation and is probably remediable. C1 UNIV CALIF BERKELEY,DEPT MAT SCI & MINERAL ENGN,BERKELEY,CA 94720. USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. RP LIU, GM (reprint author), BHP RES MELBOURNE,245 WELLINGTON RD,MULGRAVE,VIC 3170,AUSTRALIA. NR 12 TC 7 Z9 8 U1 0 U2 1 PU SOC EXPLORATION GEOPHYSICISTS PI TULSA PA 8801 S YALE ST, TULSA, OK 74137 SN 0016-8033 J9 GEOPHYSICS JI Geophysics PD DEC PY 1991 VL 56 IS 12 BP 1986 EP 1991 DI 10.1190/1.1443010 PG 6 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA GU847 UT WOS:A1991GU84700007 ER PT J AU KOVACS, A MOREY, RM AF KOVACS, A MOREY, RM TI SOUNDING SEA ICE THICKNESS USING A PORTABLE ELECTROMAGNETIC INDUCTION INSTRUMENT SO GEOPHYSICS LA English DT Article AB Field trials using a man-portable, commercially available, electromagnetic induction (EMI) sounding instrument, with a plug-in data processing module for the remote measurement of sea ice thickness, are discussed. The processing module was made to allow for the direct determination of sea ice thickness and to show the result in a numerical display. The processing module system was capable of estimating ice thickness within 10 percent of the true value for ice from about 0.7 to 3.5 m thick, the thickest of undeformed ice in our study area. However, since seawater under the Arctic pack ice has a relatively uniform conductivity (2.55 +/- 0.05 S/m), a simplified method can be used for estimating sea ice thickness using just an EMI instrument. This technique uses only the EMI conductivity measurement, is easy to put into use, and does not rely on theoretically derived look-up tables or phasor diagrams, which may not be accurate for the conditions of the area. RP KOVACS, A (reprint author), USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 12 TC 18 Z9 18 U1 1 U2 2 PU SOC EXPLORATION GEOPHYSICISTS PI TULSA PA 8801 S YALE ST, TULSA, OK 74137 SN 0016-8033 J9 GEOPHYSICS JI Geophysics PD DEC PY 1991 VL 56 IS 12 BP 1992 EP 1998 DI 10.1190/1.1443011 PG 7 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA GU847 UT WOS:A1991GU84700008 ER PT J AU PENETAR, DM SING, HC THORNE, DR THOMAS, ML FERTIG, JB SCHELLING, ASD SEALOCK, JC NEWHOUSE, PA BELENKY, G AF PENETAR, DM SING, HC THORNE, DR THOMAS, ML FERTIG, JB SCHELLING, ASD SEALOCK, JC NEWHOUSE, PA BELENKY, G TI AMPHETAMINE EFFECTS ON RECOVERY SLEEP FOLLOWING TOTAL SLEEP-DEPRIVATION SO HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL LA English DT Article DE STIMULANT; HUMAN; REM SLEEP; SLEEP STAGES AB Normal, healthy adult males participated in a sleep deprivation study during which periodic assessments of mood, alertness, cognitive performance, and vital signs were made. After 48 hours of continuous wakefulness, placebo or d-amphetamine (5, 10, 20 mg) was administered orally in a double-blind fashion. Assessments continued for an additional 14 hours at which time the subjects were allowed to sleep. A significant difference in total sleep time was observed with the highest amphetamine group (20 mg) averaging 7.0 hours vs. 8.1 hours for the placebo group. The decrease in total sleep time was due largely to a significant decrease in REM time. The number of REM episodes was not affected by drug. Latency to the first REM episode was decreased by the 5 and 10 mg dose but unchanged by the 20 mg dose of amphetamine. Amphetamine's significant effects on total sleep time and other parameters more than 15 hours after administration indicate a prolonged drug effect. RP PENETAR, DM (reprint author), WALTER REED ARMY MED CTR,DEPT BEHAV BIOL,WASHINGTON,DC 20307, USA. RI Newhouse, Paul/J-4597-2014 NR 13 TC 8 Z9 8 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0885-6222 J9 HUM PSYCHOPHARM CLIN JI Hum. Psychopharmacol.-Clin. Exp. PD DEC PY 1991 VL 6 IS 4 BP 319 EP 323 DI 10.1002/hup.470060409 PG 5 WC Clinical Neurology; Pharmacology & Pharmacy; Psychiatry; Psychology SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry; Psychology GA GR076 UT WOS:A1991GR07600008 ER PT J AU CHOWDHURY, DQ HILL, SC AF CHOWDHURY, DQ HILL, SC TI NUMERICAL OPTIMIZATION OF 3-D SAR DISTRIBUTIONS IN CYLINDRICAL MODELS FOR ELECTROMAGNETIC HYPERTHERMIA SO IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING LA English DT Article ID ANNULAR PHASED-ARRAY; REGIONAL HYPERTHERMIA; INSTITUTIONAL REPORT; HUMAN-BODY; SYSTEM; EQUIPMENT; POWER; APPLICATOR; CANCER; TISSUE AB Numerically optimized SAR (specific absorption rate) distributions in a source free 3-D multilayered concentric cylindrical (MCC) model are presented. The fields were expanded in the modes of the MCC. Cost functions which specify mathematically the relative weight assigned to differences between an SAR distribution and a desired SAR distribution were defined. The coefficients of the modes, which minimize the cost function, were obtained using gradient search optimization methods. The optimized SAR distributions shown were computed using three different cost functions and two different radial locations for the center of the region where the desired SAR is largest. A five-layered model, including the outer water layer for cooling and improved matching with the source, was used. The frequency was 70 MHz. The current and charge distributions computed on a perfectly conducting cylindrical surface just outside the model are also shown. The surface current and charge distributions depend strongly on the relative importance of the cost for acute heat and systemic heat. A technique is developed for generating a new set of basis functions for reducing the number of unknowns to be optimized. We suggest that the approach shown could be useful in designing hyperthermia applicators. C1 YALE UNIV,CTR LASER DIAGNOST,NEW HAVEN,CT 06520. NEW MEXICO STATE UNIV,DEPT ELECT & COMP ENGN,LAS CRUCES,NM 88003. ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002. RP CHOWDHURY, DQ (reprint author), YALE UNIV,DEPT APPL PHYS,NEW HAVEN,CT 06520, USA. NR 27 TC 6 Z9 6 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9294 J9 IEEE T BIO-MED ENG JI IEEE Trans. Biomed. Eng. PD DEC PY 1991 VL 38 IS 12 BP 1246 EP 1255 DI 10.1109/10.137290 PG 10 WC Engineering, Biomedical SC Engineering GA GT086 UT WOS:A1991GT08600009 PM 1774086 ER PT J AU EA, JY LU, YC ZHU, DZ LALEVIC, B AF EA, JY LU, YC ZHU, DZ LALEVIC, B TI AVALANCHE ELECTRON EMITTER ARRAYS USING SI ULTRA-SHALLOW P-N-JUNCTIONS SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Meeting Abstract C1 USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. RUTGERS STATE UNIV,DEPT ELECT & COMP ENGN,PISCATAWAY,NJ 08855. NR 0 TC 0 Z9 0 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9383 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD DEC PY 1991 VL 38 IS 12 BP 2716 EP 2716 DI 10.1109/16.158749 PG 1 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA GP300 UT WOS:A1991GP30000072 ER PT J AU KIM, A YOUMANS, RJ ZETO, R WEINER, M FISHBACK, J TSINETAKES, J LALEVIC, B AF KIM, A YOUMANS, RJ ZETO, R WEINER, M FISHBACK, J TSINETAKES, J LALEVIC, B TI PHOTOCONDUCTIVE IMPULSE GENERATION AND RADIATION SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES LA English DT Article; Proceedings Paper CT INTERNATIONAL MICROWAVE SYMP CY JUN 10-14, 1991 CL BOSTON, MA SP IEEE, MICROWAVE THEORY & TECH SOC AB The generation of extremely narrow, high peak power pulses using an optically activated impulse generator has been demonstrated. Radiative measurements at 1 Hz PRF have been conducted at pulse bias levels up to 15 kV, using an optical pulse from a Nd:YAG laser to trigger the device. The measured pulse from a wide-band antenna had a pulsewidth of 1.5 ns with a risetime of 900 ps. The frequency spectrum of this radiated waveform ranged from 50 MHz to 1 GHz. C1 USA,MICOM,HUNTSVILLE,AL 35898. GE,TRANSMITTER EQUIPMENT DESIGN GRP,MOORESTOWN,NJ 08057. RUTGERS STATE UNIV,DEPT ECE,PISCATAWAY,NJ 08855. RP KIM, A (reprint author), USA,LABCOM,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. NR 8 TC 4 Z9 4 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9480 J9 IEEE T MICROW THEORY JI IEEE Trans. Microw. Theory Tech. PD DEC PY 1991 VL 39 IS 12 BP 2026 EP 2030 DI 10.1109/22.106542 PG 5 WC Engineering, Electrical & Electronic SC Engineering GA GW458 UT WOS:A1991GW45800016 ER PT J AU KHANNA, SM CARLONE, C HALLE, S PARENTEAU, M BELIVEAU, A AKTIK, C GERDES, JW AF KHANNA, SM CARLONE, C HALLE, S PARENTEAU, M BELIVEAU, A AKTIK, C GERDES, JW TI THE PHOTOCONDUCTIVITY SPECTRUM OF ELECTRON AND NEUTRON-IRRADIATED N LIGHTLY DOPED GAAS SO IEEE TRANSACTIONS ON NUCLEAR SCIENCE LA English DT Article; Proceedings Paper CT 28TH INTERNATIONAL CONF ON NUCLEAR AND SPACE RADIATION EFFECTS CY JUL 15-19, 1991 CL SAN DIEGO, CA SP IEEE, DEFENSE NUCL AGCY, SANDIA NATL LABS, JET PROPULS LAB ID DEFECTS; SPECTROSCOPY; DEPENDENCE AB Semi-insulating samples of GaAs have been exposed to electron irradiation (7 Mev) in the fluence range 1 x 10(10) to 1 x 10(15) cm-2 and to neutron irradiation (1 Mev equivalent damage in Si) in the fluence range 7.7 x 10(14) to 2.4 x 10(16) cm-2. The spectral photoconductivity in the energy range 1.375 to 1.550 eV was obtained. From the temperature dependence of the photoconductivity, we confirm the existence of a shallow donor state (40 meV) in electron irradiated GaAs. The temperature dependence of the photoconductivity of the two types of radiations indicates that a similar shallow donor state is induced also in neutron irradiated GaAs. Photoluminescence experiments suggest 31 meV for its energy. The photoconductivity is affected more by electron irradiation (a factor of 10 in dose) than by neutron irradiation and we attribute this to the relative depth of the donor levels induced. We have measured the photoconductivity of MOCVD grown GaAs doped n (Si) (5 x 10(14) to 10(17) cm-3). We confirm in unirradiated samples the formation of an impurity band at about 10(16) cm-3. One MOCVD sample doped to 1.02 x 10(16) cm-3 was exposed to the same (1 MeV) neutron irradiation to fluences of 10(13), 10(14) and 10(15) cm-2. The temperature dependence of the photoconductivity of this sample with heavy doping is very different from that of semi-insulating samples and it is determined by deeper defect states. C1 UNIV SHERBROOKE,SHERBROOKE J1K 2R1,QUEBEC,CANADA. USA,PULSE RADIAT FACIL,ABERDEEN PROVING GROUND,MD 21010. RP KHANNA, SM (reprint author), DEF RES ESTAB,OTTAWA K1A 0Z4,ONTARIO,CANADA. NR 20 TC 5 Z9 6 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9499 J9 IEEE T NUCL SCI JI IEEE Trans. Nucl. Sci. PD DEC PY 1991 VL 38 IS 6 BP 1145 EP 1152 DI 10.1109/23.124087 PN 1 PG 8 WC Engineering, Electrical & Electronic; Nuclear Science & Technology SC Engineering; Nuclear Science & Technology GA GZ173 UT WOS:A1991GZ17300014 ER PT J AU LELIS, AJ OLDHAM, TR DELANCEY, WM AF LELIS, AJ OLDHAM, TR DELANCEY, WM TI RESPONSE OF INTERFACE TRAPS DURING HIGH-TEMPERATURE ANNEALS SO IEEE TRANSACTIONS ON NUCLEAR SCIENCE LA English DT Article; Proceedings Paper CT 28TH INTERNATIONAL CONF ON NUCLEAR AND SPACE RADIATION EFFECTS CY JUL 15-19, 1991 CL SAN DIEGO, CA SP IEEE, DEFENSE NUCL AGCY, SANDIA NATL LABS, JET PROPULS LAB ID 111 SI-SIO2 INTERFACE; MOS-TRANSISTORS; PB CENTERS; STATES; CAPACITORS; HYDROGEN; SILICON; CMOS; ELECTRONICS; PASSIVATION AB We have performed isochronal-annealing measurements on n-channel Si-gate metal-oxide semiconductor field-effect transistors (MOSFETs) to determine the temperature at which interface traps anneal following exposure to 10-keV x-rays. All five of the processes sampled exhibited annealing by 300-degrees-C, although this annealing was generally preceded by an increase in the number of interface traps (N(IT)) at lower temperatures. In particular, N(IT) for two of the processes increased at 100-degrees-C. Additional annealing experiments at 100-degrees-C for a week are consistent with these results. The implications of these results for high-temperature accelerated-annealing rebound testing are discussed. RP LELIS, AJ (reprint author), USA,HARRY DIAMOND LABS,COMMAND LAB,ADELPHI,MD 20783, USA. NR 37 TC 38 Z9 41 U1 1 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9499 J9 IEEE T NUCL SCI JI IEEE Trans. Nucl. Sci. PD DEC PY 1991 VL 38 IS 6 BP 1590 EP 1597 DI 10.1109/23.124150 PN 1 PG 8 WC Engineering, Electrical & Electronic; Nuclear Science & Technology SC Engineering; Nuclear Science & Technology GA GZ173 UT WOS:A1991GZ17300077 ER PT J AU KELLY, NM YOUNG, L CROSS, AS AF KELLY, NM YOUNG, L CROSS, AS TI DIFFERENTIAL INDUCTION OF TUMOR-NECROSIS-FACTOR BY BACTERIA EXPRESSING ROUGH AND SMOOTH LIPOPOLYSACCHARIDE PHENOTYPES SO INFECTION AND IMMUNITY LA English DT Article ID ESCHERICHIA-COLI; ENDOTOXIN; LYMPHOCYTES; HETEROGENEITY; RESISTANCE; CACHECTIN; RELEASE; ANTIGEN; BINDING; STRAINS AB The lipid A portion of the lipopolysaccharide (LPS) molecule of gram-negative bacteria has the ability to turn on the production of tumor necrosis factor (TNF) in macrophage cells. The question addressed in this paper was whether the presence of the polysaccharide moiety on the LPS molecule had any bearing on this ability. The question was asked (i) by using isolated LPS from a series of salmonella mutants having progressively less polysaccharide attached to the lipid A portion of the molecule and (ii) by using whole bacteria expressing alternatively the smooth or rough LPS phenotype. Isolated LPS and bacteria were examined for their abilities to induce bioactive TNF in the mouse macrophage cell line RAW 264.7. The results indicated that the presence of long- or short-chain polysaccharide moieties had no bearing on the ability of the isolated LPS molecule to induce TNF. However, the presence of long-chain polysaccharides attached to the lipid moiety on the intact smooth bacterium was associated with a decreased ability to induce TNF. To test whether the bacteria were inducing TNF by a cell (bacterium)-to-cell (macrophage) contact mechanism or through a releasable product, the bacteria were removed from direct contact with the macrophage cells by using a Transwell filter insert. Under these conditions the rough bacteria continued to induce TNF, while the smooth bacteria were no longer capable of doing so. When filtrates from the bacteria were examined in the Limulus amebocyte lysate assay, the results showed that the rough bacteria were releasing approximately a log order more Limulus amebocyte lysate activity than the smooth bacteria. The results of this study suggest that rough bacteria may be superior inducers of TNF compared with their smooth counterparts because of a greater propensity to shed their LPS. C1 WALTER REED ARMY MED CTR, DEPT BACTERIAL DIS, WASHINGTON, DC 20307 USA. NR 28 TC 34 Z9 34 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD DEC PY 1991 VL 59 IS 12 BP 4491 EP 4496 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA GR214 UT WOS:A1991GR21400029 PM 1937808 ER PT J AU HOPPER, KD DIEHL, LF LYNCH, JC MCCAUSLIN, MA AF HOPPER, KD DIEHL, LF LYNCH, JC MCCAUSLIN, MA TI MEDIASTINAL BULK IN HODGKIN DISEASE - METHOD OF MEASUREMENT VERSUS PROGNOSIS SO INVESTIGATIVE RADIOLOGY LA English DT Article DE HODGKIN DISEASE; BULK DISEASE; STAGING ID COMBINED MODALITY THERAPY; STAGE-IA; MULTIVARIATE-ANALYSIS; RADIATION-THERAPY; RADIOTHERAPY; CT; IRRADIATION; MANAGEMENT; MOPP; CHEMOTHERAPY AB The presence of a large mediastinal mass (bulk disease) in patients with newly diagnosed Hodgkin disease is believed by many to predict a poorer prognosis and to warrant more aggressive treatment. These masses are formed by an aggregate of mediastinal lymph nodes. The determination of bulk disease is confusing, with at least 27 definitions having been proposed. This study seeks to determine the best definition, and determine the role of thoracic computed tomography (CT) versus chest radiographs in the evaluation of mediastinal bulk disease. One hundred seven consecutive newly diagnosed adult patients with Hodgkin disease were evaluated using 13 commonly used definitions of mediastinal bulk. Of the 76 patients with mediastinal disease, 73 had bulk disease as defined by at least one definition. Of the 16 patients who had recurrence of mediastinal disease, only the presence of bulk disease according to one definition (hilar adenopathy, greater-than-or-equal-to 2 cm) was statistically significant in its prediction (P = .05). No definition based on the size of the mediastinal nodal mass reliably predicted those patients with recurrence. No differences in our data were found for differing stages or disease cell types, the presence of extension, or with differing treatment regimens. This study highlights the confusion and controversy surrounding the use of bulk disease of the mediastinum as an adverse prognostic indicator. The numerous methods of measuring mediastinal bulk in patients with newly diagnosed Hodgkin disease are confusing, overlap, and are not statistically reliable in predicting recurrence. Efforts to create a standard or ideal definition were unsuccessful. Thoracic CT was useful in those patients whose bulk disease distorted only one side of the mediastinal silhouette on chest radiographs. C1 PENN STATE UNIV,MILTON S HERSHEY MED CTR,CTR BIOSTAT & EPIDEMIOL,HERSHEY,PA 17033. UNIV HLTH SCI,DEPT RADIOL,BETHESDA,MD. UNIV HLTH SCI,DEPT MED,BETHESDA,MD. UNIV HLTH SCI,UNIFORMED SERV,BETHESDA,MD. WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. RP HOPPER, KD (reprint author), PENN STATE UNIV,MILTON S HERSHEY MED CTR,DEPT RADIOL,POB 850,HERSHEY,PA 17033, USA. NR 49 TC 10 Z9 10 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0020-9996 J9 INVEST RADIOL JI Invest. Radiol. PD DEC PY 1991 VL 26 IS 12 BP 1101 EP 1110 DI 10.1097/00004424-199112000-00015 PG 10 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA GR721 UT WOS:A1991GR72100012 PM 1765446 ER PT J AU MARTEL, CJ DIENER, CJ AF MARTEL, CJ DIENER, CJ TI A PILOT-SCALE STUDY OF ALUM SLUDGE DEWATERING IN A FREEZING BED SO JOURNAL AMERICAN WATER WORKS ASSOCIATION LA English DT Article AB The purpose of this study was to demonstrate the capability of a sludge-freezing bed for dewatering alum sludge. Alum sludge containing average total solids of 0.5 percent was applied to the pilot-scale bed and frozen in layers 2-10 cm thick over the winter of 1989-90. By the end of the winter, 99 cm of sludge had been frozen. After thawing and draining of meltwater, the depth of sludge remaining in the bed was reduced to 3-5 cm, a 96 percent reduction in volume. The remaining solids had a granular consistency similar to medium-sized sand. The meltwater drained through the granular solids as easily as through the underlying sand. Column tests show that these granular solids could accumulate in the bed for several years before removal would be necessary. RP MARTEL, CJ (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 13 TC 16 Z9 17 U1 0 U2 0 PU AMER WATER WORKS ASSN PI DENVER PA 6666 W QUINCY AVE, DENVER, CO 80235 SN 0003-150X J9 J AM WATER WORKS ASS JI J. Am. Water Work Assoc. PD DEC PY 1991 VL 83 IS 12 BP 51 EP 55 PG 5 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA GV113 UT WOS:A1991GV11300009 ER PT J AU REUSS, M AF REUSS, M TI CANALS FOR A NATION - THE CANAL ERA IN THE UNITED-STATES, 1790-1860 - SHAW,RE SO JOURNAL OF AMERICAN HISTORY LA English DT Book Review RP REUSS, M (reprint author), USA,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ORGANIZATION AMER HISTORIANS PI BLOOMINGTON PA 112 N BRYAN ST, BLOOMINGTON, IN 47408 SN 0021-8723 J9 J AM HIST JI J. Am. Hist. PD DEC PY 1991 VL 78 IS 3 BP 1062 EP 1063 DI 10.2307/2078841 PG 2 WC History SC History GA GX178 UT WOS:A1991GX17800041 ER PT J AU COFFMAN, EM AF COFFMAN, EM TI SOLDIERS AND SCHOLARS - THE UNITED-STATES-ARMY AND THE USES OF MILITARY HISTORY, 1865-1920 - REARDON,C SO JOURNAL OF AMERICAN HISTORY LA English DT Book Review RP COFFMAN, EM (reprint author), USA,COMMAND & GEN STAFF COLL,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ORGANIZATION AMER HISTORIANS PI BLOOMINGTON PA 112 N BRYAN ST, BLOOMINGTON, IN 47408 SN 0021-8723 J9 J AM HIST JI J. Am. Hist. PD DEC PY 1991 VL 78 IS 3 BP 1099 EP 1099 DI 10.2307/2078884 PG 1 WC History SC History GA GX178 UT WOS:A1991GX17800088 ER PT J AU KRANING, KK GONZALEZ, RR AF KRANING, KK GONZALEZ, RR TI PHYSIOLOGICAL CONSEQUENCES OF INTERMITTENT EXERCISE DURING COMPENSABLE AND UNCOMPENSABLE HEAT-STRESS SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE CORE TEMPERATURE; SKIN TEMPERATURE; HEAT BALANCE; HEAT STRESS; SKIN BLOOD FLOW AB Time-weighted averaging is a traditional method used in heat stress analyses to approximate, in terms of a single continuous level of heat production, the rate of heat production from complex intermittent exercise patterns. Physiological responses during intermittent and continuous exercise were studied in four subjects exposed to heat stress in which evaporation was either free or severely restricted. Intermittent work consisted of repeated 10-min exercise-rest patterns. Continuous work was at the time-weighted average of intermittent exercise: 3.3 mets. When heat stress was uncompensable, intermittent work induced more physiological strain than continuous work: endurance time was 14 min less (P < 0.05); core temperature at 60 min was 0.40-degrees-C higher (P < 0.05); and, after 30 min of exposure, the rate of core temperature rise was 33% greater. The difference in the rate of heat storage was not satisfactorily explained by a discrepancy in the average rate of heat production or in the calculated rate of surface heat loss. Alternatively, the results may be partially explained by interruptions in the usual rate of heat transport via the cutaneous circulation. These interruptions may be caused by nonthermal factors associated with postural and work load transitions. Although the mechanisms are not totally understood, it is clear that application of the time-weighted averaging method can lead to erroneous overprediction of endurance time and should be applied with discretion. RP KRANING, KK (reprint author), USA,ENVIRONM MED RES INST,DIV BIOPHYS & BIOMED MODELING,NATICK,MA 01760, USA. NR 20 TC 68 Z9 69 U1 1 U2 7 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD DEC PY 1991 VL 71 IS 6 BP 2138 EP 2145 PG 8 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA GW105 UT WOS:A1991GW10500010 PM 1778904 ER PT J AU SHITZER, A STROSCHEIN, LA SANTEE, WR GONZALEZ, RR PANDOLF, KB AF SHITZER, A STROSCHEIN, LA SANTEE, WR GONZALEZ, RR PANDOLF, KB TI QUANTIFICATION OF CONSERVATIVE ENDURANCE TIMES IN THERMALLY INSULATED COLD-STRESSED DIGITS SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE MODEL; COLD STRESS; THERMAL INSULATION; FINGERS; TOES ID MODEL AB The estimation of endurance times of the digits exposed to cold weather is performed by an analytical, one-dimensional cylindrical model. Blood perfusion effects are lumped into a volumetric heat-generation term. Cold-induced vasodilatation (CIVD) effects are not included in the present analysis. Endurance times, defined by a drop in cylinder tip temperature to 5-degrees-C, were evaluated. Parameters included in this evaluation were 1) environmental temperatures, 2) thermal insulation applied on the cylinder, 3) length of the cylinder, and 4) diameter of the cylinder. It was found that the lower the ambient temperature, the longer the finger, and the smaller its diameter, then the shorter the endurance time for the same thermal insulation. Results of the model were compared with measured data for a subject not exhibiting CIVD response to cold stress. Conformity of results calculated for an adjusted value of the volumetric heat-generation term and measured data was very good, with a maximum deviation of < 10% at only one particular point in time. This model facilitates the conservative estimation of lower bounds to thermally insulated fingers and toes exposed to cold stress. C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 24 TC 16 Z9 16 U1 0 U2 1 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD DEC PY 1991 VL 71 IS 6 BP 2528 EP 2535 PG 8 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA GW105 UT WOS:A1991GW10500063 PM 1778953 ER PT J AU BORMAN, WC PULAKOS, ED WHITE, LA OPPLER, SH AF BORMAN, WC PULAKOS, ED WHITE, LA OPPLER, SH TI MODELS OF SUPERVISORY JOB-PERFORMANCE RATINGS SO JOURNAL OF APPLIED PSYCHOLOGY LA English DT Article ID TRAINING-PROGRAMS; APPRAISAL; RATER; ACCURACY; CRITERIA; BEHAVIOR; HALO; RACE; AGE C1 PERSONNEL DECIS RES INST,MINNEAPOLIS,MN. HUMAN RESOURCES RES ORG,ALEXANDRIA,VA. USA,RES INST,ALEXANDRIA,VA. AMER INST RES,WASHINGTON,DC. RP BORMAN, WC (reprint author), UNIV S FLORIDA,DEPT PSYCHOL,TAMPA,FL 33620, USA. NR 41 TC 106 Z9 108 U1 1 U2 16 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 SN 0021-9010 J9 J APPL PSYCHOL JI J. Appl. Psychol. PD DEC PY 1991 VL 76 IS 6 BP 863 EP 872 DI 10.1037//0021-9010.76.6.863 PG 10 WC Psychology, Applied; Management SC Psychology; Business & Economics GA GT803 UT WOS:A1991GT80300013 ER PT J AU KIMURA, L PLYMYER, M MCLEAN, L YAMAGA, K LANCE, E AF KIMURA, L PLYMYER, M MCLEAN, L YAMAGA, K LANCE, E TI REACTION OF ANTIBODY TO MYCOBACTERIAL 65-KDA HEAT-SHOCK PROTEIN WITH HUMAN CHONDROCYTES SO JOURNAL OF AUTOIMMUNITY LA English DT Article ID STRESS PROTEINS; ANTIGENIC DETERMINANTS; MONOCLONAL-ANTIBODIES; AUTOIMMUNE ARTHRITIS; RHEUMATOID-ARTHRITIS; SYNOVIAL-FLUID; LYMPHOCYTES-T; TUBERCULOSIS; EPITOPE; LEPRAE C1 SHRINERS HOSP CRIPPLED CHILDREN,IMMUNOL RES LAB,1310 PUNAHOU ST,HONOLULU,HI 96826. TRIPLER ARMY MED CTR,DEPT PATHOL,HONOLULU,HI 96859. MRC,CLIN RES CTR,DEPT IMMUNOL MED,HARROW HA1 3UJ,MIDDX,ENGLAND. UNIV HAWAII,JOHN A BURNS SCH MED,DEPT TROP MED,HONOLULU,HI 96822. NR 30 TC 6 Z9 6 U1 0 U2 0 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0896-8411 J9 J AUTOIMMUN JI J. Autoimmun. PD DEC PY 1991 VL 4 IS 6 BP 881 EP 892 DI 10.1016/0896-8411(91)90051-D PG 12 WC Immunology SC Immunology GA GW998 UT WOS:A1991GW99800005 PM 1812894 ER PT J AU CROSS, AS WRIGHT, DG AF CROSS, AS WRIGHT, DG TI MOBILIZATION OF SIALIDASE FROM INTRACELLULAR STORES TO THE SURFACE OF HUMAN NEUTROPHILS AND ITS ROLE IN STIMULATED ADHESION RESPONSES OF THESE CELLS SO JOURNAL OF CLINICAL INVESTIGATION LA English DT Article DE SIALIC ACID; NEURAMINIDASE; CELL ACTIVATION; GRANULOCYTES; AGGREGATION ID POLYMORPHONUCLEAR LEUKOCYTE CHEMOTAXIS; GRANULE MEMBRANE-PROTEIN; GUINEA-PIG GRANULOCYTES; HUMAN-LIVER; ALKALINE-PHOSPHATASE; ENDOTHELIAL-CELLS; TUMOR-CELLS; SIALYL-LEX; ACID; NEURAMINIDASE AB Desialation of cell surfaces has been associated with the initiation or modification of diverse cellular functions. In these studies we have examined the subcellular distribution of sialidase (SE) in human neutrophils as well as the mobilization of this enzyme following neutrophil activation. Separation of subcellular fractions by density gradient centrifugation showed that SE is present not only in neutrophil primary and secondary granule populations, like lysozyme, but also in plasma membrane fractions. Neutrophil activation was associated with a redistribution of SE from secondary granule-enriched fractions to the plasma membrane. Furthermore, SE activity detected on the surface of intact neutrophils with a fluorescent SE substrate increased rapidly after activation with kinetics that matched both the loss of total cell-associated sialic acid and release of free sialic acid from the cells. These activation-dependent events were in each case blocked by incubation of neutrophils with the SE inhibitor, 2-deoxy-N-acetyl-neuraminic acid. Aggregation responses of neutrophils as well as adhesion responses to nylon and plastic surfaces were also inhibited by 2-deoxyNANA. Our findings indicate that the activation-dependent desialation of the neutrophil surface is associated with mobilization of an endogenous SE to the plasma membrane and has a role in stimulated adhesion responses of these cells. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP CROSS, AS (reprint author), WALTER REED ARMY MED CTR,DEPT BACTERIAL DIS,WASHINGTON,DC 20307, USA. NR 62 TC 74 Z9 76 U1 0 U2 1 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 222 E 70TH STREET, NEW YORK, NY 10021 SN 0021-9738 J9 J CLIN INVEST JI J. Clin. Invest. PD DEC PY 1991 VL 88 IS 6 BP 2067 EP 2076 DI 10.1172/JCI115536 PG 10 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA GU967 UT WOS:A1991GU96700038 PM 1721626 ER PT J AU DAWSON, JE ANDERSON, BE FISHBEIN, DB SANCHEZ, JL GOLDSMITH, CS WILSON, KH DUNTLEY, CW AF DAWSON, JE ANDERSON, BE FISHBEIN, DB SANCHEZ, JL GOLDSMITH, CS WILSON, KH DUNTLEY, CW TI ISOLATION AND CHARACTERIZATION OF AN EHRLICHIA SP FROM A PATIENT DIAGNOSED WITH HUMAN EHRLICHIOSIS SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID POLYMERASE CHAIN-REACTION; RICKETTSIA; INFECTION; DISEASE; TICKS; DNA AB A new disease was recognized in the United States in 1986. The etiologic agent, although not previously isolated from a human, appeared to be serologically related to Ehrlichia canis, a canine leukotropic rickettsia. We obtained blood specimens from 27 febrile patients with a history of tick exposure. Leukocytes from 24 patients not treated with tetracycline were placed onto a monolayer of DH82 cells. We performed indirect immunofluorescence on sera from all 27 febrile patients as well as sera from 12 patients with previously diagnosed ehrilichiosis. Intracytoplasmic inclusions were first observed in culture 35 days after the addition of infected blood from one patient. Partial sequencing of the rRNAs from the human isolate and E. canis indicated that they are 98.7% related. Positive indirect immunofluorescence reactions to the human isolate were obtained for all 12 previously diagnosed patients and for 33% of the 27 febrile patients. Two patients were seropositive for the human isolate but not for E. canis. No sera were positive for E. canis and negative for the human isolate. We report the isolation of a previously unrecognized Ehrlichia sp. that appears to be the etiologic agent of human ehrlichiosis. Serologic data (range of antibody titers, 256 to 32,768) in combination with rRNA sequencing indicated that the newly isolated Ehrlichia sp. is similar, but not identical, to E. canis. C1 VET AFFAIRS MED CTR,INFECT DIS SECT,DURHAM,NC 27705. USA,MED DEPT ACT,PREVENT MED SERV,FT SILL,OK 73503. DUKE UNIV,DEPT MED,DURHAM,NC 27706. CTR DIS CONTROL,DIV VIRAL & RICKETTSIAL DIS,OFF DIRECTOR,ATLANTA,GA 30333. WALTER REED ARMY MED CTR,DIV PREVENT MED,DEPT FIELD STUDIES,WASHINGTON,DC 20307. RP DAWSON, JE (reprint author), CTR DIS CONTROL,DIV VIRAL & RICKETTSIAL DIS,VIRAL & RICKETTSIAL ZOONOSES BRANCH,ATLANTA,GA 30333, USA. RI Anderson, Burt/H-4449-2011 NR 21 TC 294 Z9 307 U1 1 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD DEC PY 1991 VL 29 IS 12 BP 2741 EP 2745 PG 5 WC Microbiology SC Microbiology GA GP884 UT WOS:A1991GP88400012 PM 1757543 ER PT J AU BOTTIN, RR AF BOTTIN, RR TI FISHERMAN WHARF - HYDRAULIC DESIGN OF A SUCCESSFUL HARBOR PROJECT SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE FISHERMAN WHARF (SAN-FRANCISCO BAY, CALIFORNIA); HYDRAULIC MODELS; COASTAL ENGINEERING; PHYSICAL AND NUMERICAL MODELING; BREAKWATERS; WAVE ACTION; HARBOR OSCILLATION; SHIP MOTION AB Physical and numerical models were used to investigate the design of proposed breakwater configurations for wave protection in the Fisherman's Wharf area, San Francisco Bay, California. A 1:75 scale (undistorted) physical model was used to determine wave conditions in the harbor for locally generated short-period wind waves and swell conditions entering through the Golden Gate. A hybrid-finite element numerical model, capable of calculating forced harbor oscillations for harbors of arbitrary shape and variable depth, then was used to calculate harbor resonance at Fisherman's Wharf. In addition, a ship surge analysis was conducted for the historic vessels moored along or near Hyde Street Pier. An optimum plan of improvement was developed in the physical model considering wave protection afforded the harbor and entrance, ease of navigation, and economics. Numerical model test results and ship motion analysis indicated that the improvement plan would result in decreased wave amplification in the inner basins of the harbor and reduced ship response along the Hyde Street Pier. The breakwater plan was constructed at Fisherman's Wharf in 1986 and has functioned as intended to this point. In fact, the project recently won an Engineering Design Award of Merit in the U.S. Army Chief of Engineer's 20th Design and Environmental Awards Program. RP BOTTIN, RR (reprint author), USA,COASTAL ENGN RES CTR,ENGINEER WATERWAYS EXPT STN,VICKSBURG,MS 39180, USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD WIN PY 1991 VL 7 IS 1 BP 1 EP 9 PG 9 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA ET939 UT WOS:A1991ET93900002 ER PT J AU CAMFIELD, FE AF CAMFIELD, FE TI 53RD MEETING OF THE UNITED-STATES-ARMY CORPS OF ENGINEERS COASTAL ENGINEERING RESEARCH BOARD (FORT-LAUDERDALE DANIA, FLORIDA, 5-7 JUNE 1990) SO JOURNAL OF COASTAL RESEARCH LA English DT Editorial Material RP CAMFIELD, FE (reprint author), USA,COASTAL ENGN RES CTR,CTR COASTAL ENGN INFORMAT ANAL,VICKSBURG,MS 39180, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD WIN PY 1991 VL 7 IS 1 BP 261 EP 262 PG 2 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA ET939 UT WOS:A1991ET93900019 ER PT J AU SMITH, KJ SKELTON, HG ANGRITT, P JAMES, WD YEAGER, J WAGNER, K AF SMITH, KJ SKELTON, HG ANGRITT, P JAMES, WD YEAGER, J WAGNER, K TI CUTANEOUS LESIONS OF LISTERIOSIS IN A NEWBORN SO JOURNAL OF CUTANEOUS PATHOLOGY LA English DT Article ID ACQUIRED IMMUNODEFICIENCY SYNDROME; MACROPHAGES; INFECTION AB Although HIV-Infected patients are commonly infected by organisms that require an intact T cell immune system for control or eradication, there are some exceptions. The intracellular pathogen Listeria monocytogenes is one such organism. Listeriosis occurs primarily in neonates, elderly patients, patients on immune suppressive medications, cancer patients, and during pregnancy. However, listeriosis is an uncommon opportunistic infection in HIV-infected patients. We report a case of listeriosis with cutaneous lesions in a neonate born to an HIV-infected woman. C1 ARMED FORCES INST PATHOL, DEPT DERMATOPATHOL, WASHINGTON, DC 20306 USA. WALTER REED ARMY MED CTR, WASHINGTON, DC 20307 USA. WALTER REED ARMY MED CTR, DEPT DERMATOL, AIDS REGISTRY, WASHINGTON, DC 20307 USA. NATL NAVAL MED CTR, HENRY M JACKSON FDN, BETHESDA, MD 20814 USA. NATL NAVAL MED CTR, DEPT DERMATOL, BETHESDA, MD 20814 USA. NR 10 TC 4 Z9 4 U1 0 U2 0 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0303-6987 J9 J CUTAN PATHOL JI J. Cutan. Pathol. PD DEC PY 1991 VL 18 IS 6 BP 474 EP 476 DI 10.1111/j.1600-0560.1991.tb01388.x PG 3 WC Dermatology; Pathology SC Dermatology; Pathology GA GV546 UT WOS:A1991GV54600014 PM 1774359 ER PT J AU SCHNEIDER, H GRIFFISS, JM BOSLEGO, JW HITCHCOCK, PJ ZAHOS, KM APICELLA, MA AF SCHNEIDER, H GRIFFISS, JM BOSLEGO, JW HITCHCOCK, PJ ZAHOS, KM APICELLA, MA TI EXPRESSION OF PARAGLOBOSIDE-LIKE LIPOOLIGOSACCHARIDES MAY BE A NECESSARY COMPONENT OF GONOCOCCAL PATHOGENESIS IN MEN SO JOURNAL OF EXPERIMENTAL MEDICINE LA English DT Article ID NEISSERIA-GONORRHOEAE; POLYACRYLAMIDE GELS; LIPOPOLYSACCHARIDES; HETEROGENEITY; MENINGITIDIS; INFLUENZAE AB To learn how lipooligosaccharide (LOS) phase variations affect pathogenesis, we studied two male volunteers who were challenged intraurethrally with Neisseria gonorrhoeae that make a single LOS of 3,600 daltons and sequentially followed LOS expression by gonococci as urethritis developed. LOS variation occurred in vivo. Signs and symptoms of gonorrhea began with the appearance of variants making 4,700-dalton LOS that are immunochemically similar to glycosphingolipids of human hematopoietic cells (Mandrell, R. E., J. M. Griffiss, and B. A. Macher. 1989. J. Exp. Med. 168:107) and that have acceptors for sialic acid. A variant that appeared at the onset of leukorrhoea was shed by 34/36 men with naturally acquired gonorrhea at the time they sought medical attention; the other two shed the variant associated with dysuria. None shed the challenge variant. These data show that in vivo phase shifts to higher molecular mass LOS that mimic human cell membrane glycolipids are associated with the development of gonococcal leukorrhea. C1 UNIV CALIF SAN FRANCISCO,CTR IMMUNOCHEM,SAN FRANCISCO,CA 94143. UNIV CALIF SAN FRANCISCO,DEPT LAB MED,SAN FRANCISCO,CA 94143. UNIV CALIF SAN FRANCISCO,DEPT MED,SAN FRANCISCO,CA 94143. FIRST ARMY AUGMENTAT DETACHMENT,FT GEORGE G MEADE,MD 20755. NIH,ROCKY MT LABS,HAMILTON,MT 59840. GEORGE WASHINGTON UNIV,DEPT MICROBIOL & IMMUNOL,WASHINGTON,DC 20037. SUNY BUFFALO,DEPT MED,BUFFALO,NY 14215. SUNY BUFFALO,DEPT MICROBIOL,BUFFALO,NY 14215. RP SCHNEIDER, H (reprint author), WALTER REED ARMY MED CTR,DEPT BACTERIAL DIS,WASHINGTON,DC 20307, USA. FU NIAID NIH HHS [AI-18384, AI-21620] NR 21 TC 129 Z9 130 U1 0 U2 0 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 222 E 70TH STREET, NEW YORK, NY 10021 SN 0022-1007 J9 J EXP MED JI J. Exp. Med. PD DEC 1 PY 1991 VL 174 IS 6 BP 1601 EP 1605 DI 10.1084/jem.174.6.1601 PG 5 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA GU644 UT WOS:A1991GU64400034 PM 1744587 ER PT J AU MELLEN, PF CLARK, GB AF MELLEN, PF CLARK, GB TI ISOPENTANE FROZEN-SECTIONS FOR INTRAOPERATIVE DIAGNOSIS SO JOURNAL OF HISTOTECHNOLOGY LA English DT Letter RP MELLEN, PF (reprint author), WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU NATL SOC HISTOTECHNOLOGY PI BOWIE PA 4201 NORTHVIEW DR, STE 502, BOWIE, MD 20716-1073 SN 0147-8885 J9 J HISTOTECHNOL JI J. Histotechnol. PD DEC PY 1991 VL 14 IS 4 BP 285 EP 285 PG 1 WC Cell Biology SC Cell Biology GA GU900 UT WOS:A1991GU90000012 ER PT J AU FOX, CH TENNERRACZ, K RACZ, P FIRPO, A PIZZO, PA FAUCI, AS AF FOX, CH TENNERRACZ, K RACZ, P FIRPO, A PIZZO, PA FAUCI, AS TI LYMPHOID GERMINAL-CENTERS ARE RESERVOIRS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 RNA SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID FOLLICULAR DENDRITIC CELLS; IMMUNE-DEFICIENCY-SYNDROME; INSITU HYBRIDIZATION; PERIPHERAL-BLOOD; AIDS; HIV-1; NODES; LYMPHADENOPATHY; INFECTION; EXPRESSION AB When radiolabeled RNA was used for in situ hybridization, human immunodeficiency virus type 1 (HIV-1) RNA was found in high concentrations in germinal centers of lymphoid tissues from patients with HIV-1 infection. Most of the signal from hybridized probe was independent of specific cells, being found in the extracellular space of germinal centers in all lymphoid tissues examined from adult patients with Centers for Disease Control (CDC) class 11 and ill disease or pediatric patients with CDC class P-2A disease. Lymphoid tissues from adult patients with CDC class IV infections or pediatric patients with CDC class P-2D disease (including autopsy material) lacked intact germinal centers, and HIV-1 RNA was then found only in rare, isolated cells, with some tissues having no detectable HIV-1 RNA. Thus, in the early stages of HIV infection, germinal centers serve as important reservoirs of free virus in the interstitial spaces, and this reservoir disappears as the germinal centers involute with advancing disease. C1 NIAID,IMMUNOREGULAT LAB,BETHESDA,MD 20892. NCI,PEDIAT BRANCH,BETHESDA,MD 20892. ALLGEMEINES KRANKENHAUS ST GEORG,DEPT HEMATOL,HAMBURG,GERMANY. BERNHARD NOCHT INST TROP MED,DEPT PATHOL,HAMBURG,GERMANY. WALTER REED ARMY MED CTR,ARMED FORCES INST PATHOL,DIV AIDS,WASHINGTON,DC. BERNARD NOCHT INST TROP MED,KORBER LAB,HAMBURG,GERMANY. NR 26 TC 273 Z9 273 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD DEC PY 1991 VL 164 IS 6 BP 1051 EP 1057 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA GR660 UT WOS:A1991GR66000002 PM 1955708 ER PT J AU HUGGINS, JW HSIANG, CM COSGRIFF, TM GUANG, MY SMITH, JI WU, ZO LEDUC, JW ZHENG, ZM MEEGAN, JM WANG, QN OLAND, DD GUI, XE GIBBS, PH YUAN, GH ZHANG, TM AF HUGGINS, JW HSIANG, CM COSGRIFF, TM GUANG, MY SMITH, JI WU, ZO LEDUC, JW ZHENG, ZM MEEGAN, JM WANG, QN OLAND, DD GUI, XE GIBBS, PH YUAN, GH ZHANG, TM TI PROSPECTIVE, DOUBLE-BLIND, CONCURRENT, PLACEBO-CONTROLLED CLINICAL-TRIAL OF INTRAVENOUS RIBAVIRIN THERAPY OF HEMORRHAGIC-FEVER WITH RENAL SYNDROME SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID HANTAAN VIRUS-INFECTION; SUCKLING MICE AB A prospective, randomized, double-blind, concurrent, placebo-controlled clinical trial of intravenous ribavirin (loading dose of 33 mg/kg, 16 mg/kg every 6 h for 4 days, and 8 mg/kg every 8 h for 3 days) was conducted in 242 patients with serologically confirmed hemorrhagic fever with renal syndrome (HFRS) in the People's Republic of China. Mortality was significantly reduced (sevenfold decrease in risk) among ribavirin-treated patients, when comparisons were adjusted for baseline risk estimators of mortality (P = .01; two-tailed). HFRS typically consists of five consecutive but frequently overlapping clinical phases. Only occurrence of oliguric phase and hemorrhage was associated with severity of clinical disease in the placebo group. Ribavirin therapy also resulted in a significant reduction in the risk of entering the oliguric phase and experiencing hemorrhage. The only ribavirin-related side effect was a well-recognized, fully reversible anemia after completion of therapy. C1 USA,MED RES INST INFECT DIS,DEPT EPIDEMIOL,DIV MED,FREDERICK,MD. USA,MED RES INST INFECT DIS,DEPT EPIDEMIOL,DIV DIS ASSESSMENT,FREDERICK,MD. USA,MED RES INST INFECT DIS,DIV BIOMETR & INFORMAT,FREDERICK,MD. HUBEI MED UNIV,WUHAN,PEOPLES R CHINA. RP HUGGINS, JW (reprint author), USA,MED RES INST INFECT DIS,DEPT ANTIVIRAL STUDIES,DIV VIROL,FT DETRICK,FREDERICK,MD 21702, USA. NR 17 TC 236 Z9 245 U1 2 U2 11 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD DEC PY 1991 VL 164 IS 6 BP 1119 EP 1127 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA GR660 UT WOS:A1991GR66000011 PM 1683355 ER PT J AU KRISHNAMURTI, C YOUNG, GD BARR, CF COLLETON, CA ALVING, BM AF KRISHNAMURTI, C YOUNG, GD BARR, CF COLLETON, CA ALVING, BM TI ENHANCEMENT OF TISSUE PLASMINOGEN-ACTIVATOR INDUCED FIBRINOLYSIS BY ACTIVATED PROTEIN-C IN ENDOTOXIN-TREATED RABBITS SO JOURNAL OF LABORATORY AND CLINICAL MEDICINE LA English DT Article ID FAST-ACTING INHIBITOR; ENDOTHELIAL-CELLS; PLASMA; INFUSION; COAGULATION; THROMBOSIS; GENERATION; PLATELETS; MECHANISM; PATHWAYS AB Endotoxin-treated rabbits produce high levels of plasminogen activator inhibitor-1 (PAI-1), which inhibits fibrinolysis by neutralizing endogenous tissue-type plasminogen activator (t-PA). These animals will develop renal fibrin deposition when infused with Ancrod, an enzyme that acts directly on fibrinogen. In normal rabbits with an intact fibrinolytic system, ancrod induces hypofibrinogenemia without fibrin deposition. Rabbit PAI-1 activity can be neutralized by recombinant human t-PA or by bovine activated protein C. The present study determined the efficacy of these two agents used alone or in combination in neutralizing increased PAI-1 activity and in preventing renal fibrin deposition in a rabbit model. Male New Zealand rabbits first received intravenous endotoxin to increase PAI-1 activity. Ancrod was infused intravenously during hour 4 to 5, and the kidneys were examined at hour 5.5. Renal fibrin deposition occurred in 100% (6 out of 6) of the endotoxin-treated rabbits that received ancrod; this was reduced to 14% (1 out of 7) for rabbits receiving t-PA (170-mu-g/kg) before and during the ancrod infusion. Fibrin deposition occurred in only 12% (1 out of 8) of the rabbits that received a 10-fold lower dose of t-PA (17-mu-g/kg) combined with activated protein C (1 mg/kg) before and during the ancrod. Activated protein C at this dose completely neutralized plasma PAI-1 activity. However, low-dose t-PA and activated protein C did not prevent fibrin deposition when used as single agents, with fibrin deposition occurring in 75% and 100% of rabbits, respectively. The data indicate that activated protein C can neutralize plasma PAI-1 activity in vivo. Although activated protein C was not effective as a single agent in this model in preventing renal fibrin deposition, it enhanced the fibrinolytic efficacy of low-dose t-PA. C1 WALTER REED ARMY MED CTR,DIV PATHOL,WASHINGTON,DC 20307. RP KRISHNAMURTI, C (reprint author), WALTER REED ARMY MED CTR,DEPT HEMATOL,WASHINGTON,DC 20307, USA. NR 39 TC 28 Z9 30 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-2143 J9 J LAB CLIN MED JI J. Lab. Clin. Med. PD DEC PY 1991 VL 118 IS 6 BP 523 EP 530 PG 8 WC Medical Laboratory Technology; Medicine, General & Internal; Medicine, Research & Experimental SC Medical Laboratory Technology; General & Internal Medicine; Research & Experimental Medicine GA GT053 UT WOS:A1991GT05300003 PM 1744501 ER PT J AU LAL, RB BRODINE, SK COLIGAN, JE ROBERTS, CR AF LAL, RB BRODINE, SK COLIGAN, JE ROBERTS, CR TI DIFFERENTIAL ANTIBODY RESPONSIVENESS TO P19 GAG RESULTS IN SEROLOGICAL DISCRIMINATION BETWEEN HUMAN T-LYMPHOTROPIC VIRUS TYPE-I AND TYPE-II SO JOURNAL OF MEDICAL VIROLOGY LA English DT Article DE HTLV-I/II; GAG ANTIBODY; LINEAR EPITOPES ID CELL LEUKEMIA-VIRUS; COMPLETE NUCLEOTIDE-SEQUENCE; HTLV-II; INFECTION; ANTIGENS; LYMPHOMA; GENE AB A new algorithm based upon the differential antibody responses to two gag gene products (p19 and p24) of human T lymphotropic virus (HTLV) has been suggested for serologic discrimination of HTLV type I (HTLV-I) and type II (HTLV-II) [Lillihoj et al., 1990]. To evaluate the practical usefulness of this algorithm, serum specimens from HTLV-seropositive individuals whose infection was confirmed by PCR analysis to be HTLV-I (n = 60) or HTLV-II (n = 61) were analyzed by western blot. The intensities of the antibody response to p24gag and p19gag were scored by one individual without prior knowledge of PCR results. According to the algorithm, specimens with p19 greater-than-or-equal-to p24 were classified as HTLV-I, whereas specimens with p19 < p24 were classified as HTLV-II. Of 60 PCR confirmed HTLV-I specimens, 56 had p19 greater-than-or-equal-to p24 (93%) while 4 had p19 < p24. Of 61 PCR confirmed HTLV-II specimens, 56 had p19 < p24 (92%) and 5 had p19 greater-than-or-equal-to p24. The overall accuracy of serologic differentiation when using this algorithm was 92%, as 4 of 60 HTLV-I (7%) and 5 of 61 HTLV-II (8%) could have been wrongly classified. Although the differential antibody response to p19gag and p24gag provides a simple means of serologically distinguishing between HTLV-I and HTLV-II infection in population-based epidemiological studies, in a clinical context more accurate means of confirmation are required. The dominant p19gag responses were mapped to the C-terminus of p19 (p19(102-117)). Competitive inhibition of p19gag response by peptide p19(102-107), however, did not abrogate the binding of serum specimens from HTLV-I-infected individuals. C1 USN HOSP,DIV INFECT DIS,SAN DIEGO,CA 92134. NIAID,BIOL RESOURCES BRANCH,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,DEPT DIAGNOST RETROVIROL,WASHINGTON,DC 20307. RP LAL, RB (reprint author), CTR DIS CONTROL,DIV VIRAL & RICKETTSIAL DIS,RETROVIRUS DIS BRANCH,ATLANTA,GA 30333, USA. NR 21 TC 22 Z9 22 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0146-6615 J9 J MED VIROL JI J. Med. Virol. PD DEC PY 1991 VL 35 IS 4 BP 232 EP 236 DI 10.1002/jmv.1890350404 PG 5 WC Virology SC Virology GA GR591 UT WOS:A1991GR59100003 PM 1687064 ER PT J AU SWANSON, SJ SKOOG, SJ GARCIA, V WAHL, RC AF SWANSON, SJ SKOOG, SJ GARCIA, V WAHL, RC TI PSEUDOADRENAL MASS - UNUSUAL PRESENTATION OF BRONCHOGENIC CYST SO JOURNAL OF PEDIATRIC SURGERY LA English DT Article DE BRONCHOGENIC CYST, ABDOMINAL C1 WALTER REED ARMY MED CTR,DEPT PEDIAT UROL,PEDIAT UROL SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT PEDIAT SURG,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,PEDIAT PATHOL SECT,WASHINGTON,DC 20306. RP SKOOG, SJ (reprint author), WALTER REED ARMY MED CTR,DEPT PEDIAT UROL,PEDIAT UROL SERV,WASHINGTON,DC 20307, USA. NR 11 TC 29 Z9 30 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0022-3468 J9 J PEDIATR SURG JI J. Pediatr. Surg. PD DEC PY 1991 VL 26 IS 12 BP 1401 EP 1403 DI 10.1016/0022-3468(91)91046-2 PG 3 WC Pediatrics; Surgery SC Pediatrics; Surgery GA GV167 UT WOS:A1991GV16700015 PM 1765920 ER PT J AU REED, LH JAYASURIA, K KOOVAKKAT, SK ALLEN, LC AF REED, LH JAYASURIA, K KOOVAKKAT, SK ALLEN, LC TI ESTIMATION OF THERMODYNAMIC STABILITY AND CHARGE-DISTRIBUTION FOR UNKNOWN MOLECULES - NITRO-DERIVATIVES OF CUBANE SO JOURNAL OF PHYSICAL ORGANIC CHEMISTRY LA English DT Article ID STRAIN ENERGIES; CHEMISTRY AB Three useful procedures for estimating the thermodynamic stability and charge distribution of moderately complex unknown species are illustrated by the successive nitration of cubane. (1) Five different, but interrelated, energy criteria are employed, which leads to mutually supportive conclusions that overcome deficiencies in any one of the single measures. (2) Mulliken charge and overlap populations can lead to correct bond strength trends if appropriate averaging over bond types is carried out. (3) Lewis-Langmuir atomic charges, an interpolation between the formal charges of Lewis dot structures and oxidation numbers which does not require use of computers, provides atomic charges similar to those from ab initio wavefunctions. The simplicity of this scheme aids in identifying the chemical and topological origin of molecular charge distributions. Ab initio calculations for the strain energies and heats of reaction for four different reaction sequences are reported, together with Mulliken atomic charges and overlap populations for the nitrocubanes. Trends in these measures suggest that hexa- and octa-nitrocubane are thermodynamically stable species. C1 PRINCETON UNIV,DEPT CHEM,PRINCETON,NJ 08544. USA,GEO CTR INC,ARDEC,PICATINNY ARSENAL,NJ 07806. BERLEX LABS INC,CEDAR KNOLLS,NJ 07927. NR 24 TC 6 Z9 7 U1 1 U2 2 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0894-3230 J9 J PHYS ORG CHEM JI J. Phys. Org. Chem. PD DEC PY 1991 VL 4 IS 12 BP 714 EP 720 DI 10.1002/poc.610041203 PG 7 WC Chemistry, Organic; Chemistry, Physical SC Chemistry GA GX638 UT WOS:A1991GX63800002 ER PT J AU MCCARTNEY, J AF MCCARTNEY, J TI INTRAORAL CONNECTION OF INDIVIDUAL ABUTMENT ATTACHMENTS FOR AN OSSEOINTEGRATED IMPLANT-SUPPORTED PROSTHESIS SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article AB A technique is demonstrated for simultaneous verification of abutment replica positions and accurate adaptation of the prosthesis framework to the abutments. A separate procedure to verify abutment replica positions, as well as potential soldering of the framework for long-span castings, is avoided. C1 TRIPLER ARMY MED CTR,PROSTHODONT & MAXILLOFACIAL PROSTHET,HONOLULU,HI 96859. NR 4 TC 11 Z9 11 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD DEC PY 1991 VL 66 IS 6 BP 799 EP 803 DI 10.1016/0022-3913(91)90420-2 PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA GR859 UT WOS:A1991GR85900019 PM 1805034 ER PT J AU KRANTZ, WA ADRIAN, ED IVANHOE, JR AF KRANTZ, WA ADRIAN, ED IVANHOE, JR TI COMBINING FINAL IMPRESSIONS AND THE CENTRIC JAW RELATION RECORDS INTO ONE APPOINTMENT BY USING AN IRREVERSIBLE HYDROCOLLOID BLOCKOUT TECHNIQUE SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Letter C1 REMOVABLE PROSTHODONT SERV,FT GORDON,GA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD DEC PY 1991 VL 66 IS 6 BP 821 EP 822 DI 10.1016/0022-3913(91)90426-W PG 2 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA GR859 UT WOS:A1991GR85900025 PM 1805040 ER PT J AU WAYMACK, JP FLESCHER, E VENKATRAMAN, J FERNANDES, G GUZMAN, RF YURT, RW MASON, AD PRUITT, BA AF WAYMACK, JP FLESCHER, E VENKATRAMAN, J FERNANDES, G GUZMAN, RF YURT, RW MASON, AD PRUITT, BA TI EFFECT OF PROSTAGLANDIN-E IN MULTIPLE EXPERIMENTAL-MODELS .8. EFFECT ON HOST RESPONSE TO METASTATIC TUMOR SO JOURNAL OF SURGICAL ONCOLOGY LA English DT Article DE IMMUNOLOGY; LYMPHOCYTES; NK CELLS; CARCINOMA ID ADENOSINE-DEAMINASE; INHIBITION; SUPPRESSION; INDOMETHACIN; INDUCTION; CULTURE; CANCER; CELLS AB Prostaglandin E (PGE) is produced by certain tumors and is reported to decrease primary tumor growth. We evaluated its effect in multiple tumor models utilizing a 1 week course of the long acting PGE derivative dimethyl-PGE (dPGE) at a dosage of 100-mu-g/kg/day vs. a lactated Ringers control. For all tumor models, a suspension of 1 x 10(6) colon carcinoma cells were injected into Wistar-Furth rats. When the suspension was injected subcutaneously and the drug was begun at the time of tumor challenge, there was no effect on survival. When the tumor was injected intraperitoneally or intravenously and the drug begun at the time of tumor challenge, dPGE decreased survival time. When the tumor was administered intravenously but dPGE was delayed for 5 days, there was no effect on survival time. When rats were given a 1 week course of dPGE or saline, dPGE was found not to alter natural killer (NK) cell cytotoxicity, macrophage cytotoxicity, spontaneous lymphocyte blastogenesis, or mitogen stimulated blastogenesis. dPGE failed to alter lymphocyte metabolism of glucose in nonstimulated lymphocytes, but decreased the rate of glucose metabolism and adenosine deaminase activity in mitogen stimulated lymphocytes. In conclusion, PGE appears to enhance metastatic growth of tumor lines where it does not alter primary tumor growth. This effect does not appear immunologically mediated. C1 UNIV TEXAS,HLTH SCI CTR,DEPT MED,SAN ANTONIO,TX 78284. CORNELL UNIV,MED CTR,DEPT SURG,NEW YORK,NY 10021. RP WAYMACK, JP (reprint author), USA,INST SURG RES,LIB BRANCH,FT SAM HOUSTON,TX 78234, USA. FU NIA NIH HHS [AG03417] NR 25 TC 12 Z9 12 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0022-4790 J9 J SURG ONCOL JI J. Surg. Oncol. PD DEC PY 1991 VL 48 IS 4 BP 239 EP 245 DI 10.1002/jso.2930480406 PG 7 WC Oncology; Surgery SC Oncology; Surgery GA GU232 UT WOS:A1991GU23200005 PM 1745048 ER PT J AU SAMLASKA, CP AF SAMLASKA, CP TI CONGENITAL SUPRASPINOUS FOSSAE SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Note ID RETARDATION; DIMPLES RP SAMLASKA, CP (reprint author), TRIPLER ARMY MED CTR,DERMATOL SERV,HONOLULU,HI 96859, USA. NR 12 TC 3 Z9 3 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD DEC PY 1991 VL 25 IS 6 BP 1078 EP 1079 DI 10.1016/S0190-9622(08)80442-2 PN 1 PG 2 WC Dermatology SC Dermatology GA GR426 UT WOS:A1991GR42600018 PM 1810986 ER PT J AU DOHM, DJ ROMOSER, WS TURELL, MJ LINTHICUM, KJ AF DOHM, DJ ROMOSER, WS TURELL, MJ LINTHICUM, KJ TI IMPACT OF STRESSFUL CONDITIONS ON THE SURVIVAL OF CULEX-PIPIENS EXPOSED TO RIFT-VALLEY FEVER VIRUS SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article ID EGYPT 1977-78; DIPTERA; CULICIDAE; VECTOR; KENYA AB Several groups of Rift Valley fever (RVF) virus-exposed and unexposed Culex pipiens were allowed differential access to a carbohydrate food source and their survival monitored. When stressed by deprivation of a carbohydrate source, mean survival times of RVF virus-exposed mosquitoes were consistently higher than those of unexposed mosquitoes in each of the carbohydrate-deficient experiments. These differences were statistically significant when mosquitoes were provided 5% sucrose for 24 hours. Mosquitoes that were provided access to a carbohydrate source for 24 h after a bloodmeal and then were denied access survived significantly longer than did those mosquitoes denied access, regardless of their exposure to RVF virus. When not stressed, RVF virus-exposed individuals had slightly higher daily survival rates than did unexposed individuals. RP DOHM, DJ (reprint author), USA,MED RES INST INFECT DIS,DEPT ARBOVIRAL ENTOMOL,FREDERICK,MD 21701, USA. NR 18 TC 6 Z9 7 U1 0 U2 1 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD DEC PY 1991 VL 7 IS 4 BP 621 EP 623 PG 3 WC Entomology SC Entomology GA GZ479 UT WOS:A1991GZ47900018 PM 1787408 ER PT J AU LEWIS, PAW STEVENS, JG AF LEWIS, PAW STEVENS, JG TI NONLINEAR MODELING OF TIME-SERIES USING MULTIVARIATE ADAPTIVE REGRESSION SPLINES (MARS) SO JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION LA English DT Article DE ASTAR MODELS; LIMIT CYCLES; NONLINEAR TIME SERIES MODELS; RECURSIVE PARTITIONING; THRESHOLD MODELS; WOLF SUNSPOT NUMBERS AB Multivariate Adaptive Regression Splines (MARS) is a new methodology, due to Friedman, for nonlinear regression modeling. MARS can be conceptualized as a generalization of recursive partitioning that uses spline fitting in lieu of other simple fitting functions. Given a set of predictor variables, MARS fits a model in the form of an expansion in product spline basis functions of predictors chosen during a forward and backward recursive partitioning strategy. MARS produces continuous models for high-dimensional data that can have multiple partitions and predictor variable interactions. Predictor variable contributions and interactions in a MARS model may be analyzed using an ANOVA style decomposition. By letting the predictor variables in MARS be lagged values of a time series, one obtains a new method for nonlinear autoregressive threshold modeling of time series. A significant feature of this extension of MARS is its ability to produce models with limit cycles when modeling time series data that exhibit periodic behavior. In a physical context, limit cycles represent a stationary state of sustained oscillations, a satisfying behavior for any model of a time series with periodic behavior. Analysis of the yearly Wolf sunspot numbers with MARS appears to give an improvement over existing nonlinear threshold and bilinear models. A graphical representation for the models is given. C1 USA,WASHINGTON,DC 20310. RP LEWIS, PAW (reprint author), NAVAL POST GRAD SCH,STAT & OPERAT RES,MONTEREY,CA 93943, USA. NR 19 TC 77 Z9 78 U1 0 U2 6 PU AMER STATIST ASSN PI ALEXANDRIA PA 1429 DUKE ST, ALEXANDRIA, VA 22314 SN 0162-1459 J9 J AM STAT ASSOC JI J. Am. Stat. Assoc. PD DEC PY 1991 VL 86 IS 416 BP 864 EP 877 DI 10.2307/2290499 PG 14 WC Statistics & Probability SC Mathematics GA GU050 UT WOS:A1991GU05000005 ER PT J AU GERARDI, GJ POINDEXTER, EH HARMATZ, M WARREN, WL NICOLLIAN, EH EDWARDS, AH AF GERARDI, GJ POINDEXTER, EH HARMATZ, M WARREN, WL NICOLLIAN, EH EDWARDS, AH TI DEPASSIVATION OF DAMP-OXIDE PB CENTERS BY THERMAL AND ELECTRIC-FIELD STRESS SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID SILICON DIOXIDE FILMS; MOS DEVICES; INTERFACE DEFECTS; SPIN RESONANCE; HYDROGEN; OXIDATION; MOLECULES; STATES; TRAPS AB The kinetics of thermal and electric field-induced depassivation of P(b) centers in damp oxide Si/SiO2 systems have been examined. Negative field-induced depassivation is maximized at intermediate oxide water content, while the activation energy E(a) for thermal depassivation is minimized. The thermal E(a) in damp-oxides is about 0.6 eV, and for dry and wet oxides, 2.5 eV and 2 eV, respectively. This unusual reaction fingerprint is compared to well-characterized charge-transfer processes in other systems. The activation minimum and correlated P(b) maximum suggest the so-called Marcus inversion regime or the "volcano" effect. It is then argued that the depassivation is explainable by a single rate-limiting reaction of the form SiH + A + hole+ --> Si. + AH+, where A is a hydrogenous species. Some aspects of the observed depassivation are in accord with the negative bias temperature instability (NBTI) in metal oxide silicon structures; however, there are important differences. The extended electrochemical and physical arguments developed for the depassivation have significant implications for other Si/SiO2 physicochemical phenomena, such as radiation damage and oxidation mechanisms. C1 USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. UNIV N CAROLINA,DEPT ELECT ENGN,CHARLOTTE,NC 28223. RP GERARDI, GJ (reprint author), WILLIAM PATERSON STATE COLL,DEPT CHEM,WAYNE,NJ 07470, USA. NR 46 TC 24 Z9 24 U1 1 U2 2 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 10 SOUTH MAIN STREET, PENNINGTON, NJ 08534 SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PD DEC PY 1991 VL 138 IS 12 BP 3765 EP 3770 DI 10.1149/1.2085497 PG 6 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA GT518 UT WOS:A1991GT51800052 ER PT J AU COSTABILE, RA HAHN, M MCLEOD, DG AF COSTABILE, RA HAHN, M MCLEOD, DG TI CHRONIC ORCHIALGIA IN THE PAIN PRONE PATIENT - THE CLINICAL PERSPECTIVE SO JOURNAL OF UROLOGY LA English DT Article DE PAIN; TESTICULAR DISEASES; SCROTUM ID DEPRESSION AB Chronic pain syndromes are well known to the medical community. The incidence of chronic pain syndromes and cost of evaluating these patients are rapidly increasing. Chronic testicular pain is a fairly common manifestation of a chronic pain syndrome. Retrospectively, we reviewed the records of 48 patients with chronic testicular or scrotal pain (greater than 6 months) evaluated at our institution during the last 7 years. These patients had multiple diagnostic and interventional procedures with few positive findings. There was little improvement in these patients after multiple surgical procedures. Based on the paucity of objective clinical findings a carefully directed diagnostic evaluation for orchialgia is outlined. The treatment of these patients is best managed by a multidisciplinary approach involving the urologist and a pain clinic environment. We believe that extensive diagnostic testing is not indicated in the absence of clinical findings and may serve to worsen the condition or lead to iatrogenic injury. Surgical intervention should be limited to cases when a clear indication is present. C1 WALTER REED ARMY MED CTR,PAIN MANAGEMENT CLIN,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 16 TC 52 Z9 52 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD DEC PY 1991 VL 146 IS 6 BP 1571 EP 1574 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA GR667 UT WOS:A1991GR66700026 PM 1942343 ER PT J AU PEPPAS, DS SKOOG, SJ CANNING, DA BELMAN, AB AF PEPPAS, DS SKOOG, SJ CANNING, DA BELMAN, AB TI NONSURGICAL MANAGEMENT OF PRIMARY VESICOURETERAL REFLUX IN COMPLETE URETERAL DUPLICATION - IS IT JUSTIFIED SO JOURNAL OF UROLOGY LA English DT Article DE VESICOURETERAL REFLUX; URETER ID CHILDREN AB We reviewed the treatment of 56 children with vesicoureteral reflux and complete duplication of the collecting system, including 14 who had complete bilateral duplication. A total of 70 refluxing duplicated systems was analyzed. Of the patients 18% demonstrated spontaneous resolution of reflux within 42 months, 23% are currently stable on prophylactic antibiotics and 57.1% underwent surgical correction. Spontaneous resolution of reflux occurred in 58% of the children with grades I to III/V reflux. In comparing the group with reflux and duplication to a group with reflux into single systems, we conclude that the patients with duplication and lower grades of reflux can be managed nonoperatively, while infection is prevented with antibiotic prophylaxis. C1 CHILDRENS HOSP,NATL MED CTR,DEPT UROL,111 MICHIGAN AVE NW,WASHINGTON,DC 20010. CHILDRENS HOSP,NATL MED CTR,DEPT PEDIAT,WASHINGTON,DC 20010. WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307. GEORGE WASHINGTON UNIV,SCH MED,WASHINGTON,DC 20052. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 9 TC 18 Z9 18 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD DEC PY 1991 VL 146 IS 6 BP 1594 EP 1595 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA GR667 UT WOS:A1991GR66700033 PM 1942349 ER PT J AU GUO, ZM LIU, CT AF GUO, ZM LIU, CT TI PULMONARY RESPONSES OF CONSCIOUS STRAIN-13 GUINEA-PIGS TO PICHINDE VIRAL-INFECTION SO LABORATORY ANIMAL SCIENCE LA English DT Article ID HEMORRHAGIC-FEVER; ANTAGONIST; VIRUS AB A laboratory animal model for studying pulmonary responses to arenaviral infection was established with advanced technologies. Tidal volume (TV), respiratory rate (RR), minute volume (MV), expiratory time (TE), inspiratory time (TI), peak expiratory flow (PEF), and specific pulmonary airway resistance (RES) were measured with a double plethysmograph and a computer data-acquisition system in six conscious, strain 13 guinea pigs. Using the same animal, experiments were conducted before and after subcutaneous inoculation with 10(4) plaque-forming units of Pichinde virus. Pulmonary functions were determined for 1 minute every 10 minutes for 2 hours before and at postinoculation days (PID) 3,6, 8, and daily thereafter until shortly before death. The mean time to death was 18 +/- 0.7 days. Tidal volume, RR, MV, PEF, RES, and rectal temperature increased slightly on PED 3 and reached peak values at the midpoint of disease. At 95% of the mean time to death (16.5 +/- 0.5 days), RR, MV, and rectal temperatures suddenly decreased to lower than baseline values; while TV, RES, and PEF values remained high. When TE decreased with the increase in RR, TI did not change. When RR decreased at the terminal stage, both TE and TI increased. Hyperventilation, increased specific pulmonary airway resistance, terminal hypoventilation, and respiratory arrest were noted in strain 13 guinea pigs infected with Pichinde virus. RP GUO, ZM (reprint author), USA,MED RES INST INFECT DIS,DEPT CLIN & EXPTL PHYSIOL,DIV DIS ASSESSMENT,FT DETRICK,FREDERICK,MD 21702, USA. NR 12 TC 8 Z9 8 U1 0 U2 0 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI CORDOVA PA 70 TIMBERCREEK DR, SUITE 5, CORDOVA, TN 38018 SN 0023-6764 J9 LAB ANIM SCI JI Lab. Anim. Sci. PD DEC PY 1991 VL 41 IS 6 BP 581 EP 584 PG 4 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA HG813 UT WOS:A1991HG81300011 PM 1667202 ER PT J AU KATZ, RN AF KATZ, RN TI COMPUTERS - THE KEY TO RELIABLE CERAMIC MATERIALS AND COMPONENTS SO MATERIALS CHARACTERIZATION LA English DT Article; Proceedings Paper CT SYMP AT THE 22ND ANNUAL CONVENTION OF THE INTERNATIONAL METALLOGRAPHIC SOC : COMPUTER-AIDED MATERIALS CHARACTERIZATION CY JUL 23-24, 1989 CL CHARLOTTE, NC SP INT METALLOG SOC ID HIGH-PERFORMANCE CERAMICS AB Advanced structural ceramic components are increasingly used in demanding engineering applications. A major impediment to even wider utilization are issues related to reliability and affordability. Exercising greater control over the inherent flaw population in the ceramic component will contribute importantly to resolving these two issues. Computers will play an ever-increasing role in designing to minimize the impact of flaws, in processing to minimize the presence of flaws, and in nondestructive testing (NDT) to assure the absence of critical flaws for reliable, affordable ceramic components. This article reviews the state of the art and/or the potential for the application of computers in the design, fabrication, and inspection of structural ceramic components. A strategy for the integration of design, processing and NDT will be presented. RP KATZ, RN (reprint author), USA,MAT TECHNOL LAB,WATERTOWN,MA 02172, USA. NR 35 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 1044-5803 J9 MATER CHARACT JI Mater. Charact. PD DEC PY 1991 VL 27 IS 4 BP 281 EP 295 DI 10.1016/1044-5803(91)90043-4 PG 15 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering; Materials Science, Characterization & Testing SC Materials Science; Metallurgy & Metallurgical Engineering GA GY279 UT WOS:A1991GY27900010 ER PT J AU LONGMIRE, AW DESHMUKH, N AF LONGMIRE, AW DESHMUKH, N TI THE MEDICAL-CARE OF IRAQI ENEMY PRISONERS OF WAR SO MILITARY MEDICINE LA English DT Article AB During Operation Desert Storm, Approximately 62,000 enemy prisoners of war (EPWs) were captured by allied forces. Most of these EPWs were taken during the ground war and the weeks following. Over 20,000 of these were interned at East Camp, which was located approximately 125 miles south of the Kuwaiti border. The 300th Field Hospital was tasked to provide inpatient and outpatient care to the EPWs. This paper summarizes the experience, analyzing the diseases encountered, the types of medicines needed, and the unique problems of treating non-English speaking EPWs. From January 27 to February 23, 1991, approximately 308 patients were treated. From the beginning of the ground war on February 24, through March 30, approximately 8,979 patients were treated. The most common condition seen was dental disease (24.0%). Other commonly treated conditions were upper respiratory infection (12.4%), headache (11.7%), and urinary tract infections (9.6%). The unique problems of language barriers and security requirements increased the difficulty and the time required to conduct sick call for Iraqi EPWs. RP LONGMIRE, AW (reprint author), USA,300TH FIELD HOSP,WASHINGTON,DC 20310, USA. NR 0 TC 4 Z9 4 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 1991 VL 156 IS 12 BP 645 EP 648 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA GV758 UT WOS:A1991GV75800009 PM 1780062 ER PT J AU DRISCOLL, DM AF DRISCOLL, DM TI BURN DRESSINGS - A CRITICAL INDICATOR FOR PATIENT-CARE CLASSIFICATION IN BURN UNITS SO MILITARY MEDICINE LA English DT Article AB Nursing services consume approximately 60% of a hospital personnel budget, requiring justification for staffing levels and manpower expenses. The lack of an adequate level of nursing care affects the operation of the entire health care team. The purpose of this descriptive study is to establish the mean tasking time to apply burn dressings. The number of nursing staff required to complete a burn dressing application is dependent on the location of injury and the ability of the patient to cooperate. Establishing the essential mean tasking time for routine post-operative dressing assists in the production of accurate reporting of nursing manpower requirements. RP DRISCOLL, DM (reprint author), USA,INST SURG RES,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 1991 VL 156 IS 12 BP 654 EP 657 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA GV758 UT WOS:A1991GV75800012 PM 1780065 ER PT J AU SHANKS, GD KARWACKI, JJ AF SHANKS, GD KARWACKI, JJ TI MALARIA AS A MILITARY FACTOR IN SOUTHEAST-ASIA SO MILITARY MEDICINE LA English DT Article AB Malaria remains a major cause of military casualities in South-east Asia. The numerous conflicts in the region have been greatly affected by malaria. Besides guerrilla warfare, refugees and other civilian movements across international borders contribute heavily to the continuing problem of multiple drug-resistant malaria. Drug resistance is an increasing problem with few available prophylactic options. The malaria threat to any potential deployment of United States military forces remains unsolved. RP SHANKS, GD (reprint author), ARMED FORCES INST MED SCI, USA, MED COMPONENT, DEPT MED, APO, SAN FRANCISCO, CA 96346 USA. RI Shanks, George Dennis/F-4056-2014 OI Shanks, George Dennis/0000-0001-5763-8660 NR 0 TC 9 Z9 9 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD DEC PY 1991 VL 156 IS 12 BP 684 EP 686 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA GV758 UT WOS:A1991GV75800020 ER PT J AU HOWES, KA MENENDEZPELAEZ, A REITER, RJ VAUGHAN, MK HENSEL, CH VAUGHAN, GM AF HOWES, KA MENENDEZPELAEZ, A REITER, RJ VAUGHAN, MK HENSEL, CH VAUGHAN, GM TI SERUM LUTEINIZING-HORMONE, PROLACTIN, AND THYROTROPIN AND THEIR PITUITARY SUBUNIT MESSENGER-RNA LEVELS DURING PROESTRUS IN THE SYRIAN-HAMSTER SO NEUROENDOCRINOLOGY LA English DT Article DE LUTEINIZING HORMONE; PROLACTIN; THYROID-STIMULATING HORMONE; RNA; ESTRUS ID GONADOTROPIN-RELEASING HORMONE; RIBONUCLEIC-ACID CONCENTRATIONS; FOLLICLE-STIMULATING-HORMONE; RAT ESTROUS-CYCLE; GENE-TRANSCRIPTION; LH; 17-BETA-ESTRADIOL; BIOSYNTHESIS; PROGESTERONE; SECRETION AB mRNA levels for alpha, luteinizing hormone beta (LH-beta), and prolactin (Prl) were examined during the hamster estrous cycle, with sampling most frequent (1-hour intervals) on the afternoon of proestrus. These transcripts encode the peptide subunits for the pituitary hormones LH and Prl which are necessary for reproductive function. Serum hormone levels of LH and Prl, analyzed by 24-hour periodic regression, exhibited a 24-hour periodicity on proestrus characterized by a large surge peaking at about 18.00 h. Combining the data for non-proestrous days of the cycle disclosed a rhythm with similar timing for LH and Prl. Thyroid-stimulating hormone (TSH) and TSH-beta RNA profiles during hamster proestrus are reported for the first time. Serum TSH exhibited a pronounced peak coincident with that of the other hormones on proestrus. Because of variations at other times on the day of proestrus, however, a 24-hour periodicity was not manifested by regressional analysis. Combined non-proestrous serum TSH data also revealed no consistently timed regressional 24-hour periodicity. During proestrus, pituitary mRNA values for alpha, LH-beta, and Prl simultaneously exhibited a rise from the lowest to the highest of all proestrous values in the 3-5 h prior to the time of the pre-ovulatory peak of circulating hormone concentrations. RNA for TSH-beta exhibited an earlier, broader peak on proestrus. Periodic regression indicated a significant 24-hour rhythm for alpha mRNA in data pooled from non-proestrous days (acrophase 05.00 h) and for TSH-beta mRNA on proestrus (acrophase 04.54 h). The necessity to pool the pituitary tissue from animals at particular time points limits the opportunity for statistical analysis of the mRNA levels. However, it is interesting that, on the afternoon of proestrus, the fluctuations of mRNAs for alpha-subunit, LH-beta, and prolactin were the widest for that day, were simultaneous, and preceded the hormone peak by 3-5 h; also, that the earlier rise of TSH-beta mRNA on proestrus was detectable as a 24-hour rhythm. It is thus possible to hypothesize that a fluctuation in respective mRNA related to LH, Prl and TSH may occur in the hours preceding the proestrous surge of these hormones in the circulation, and may thus play a role in the hormonal surge. C1 UNIV TEXAS,HLTH SCI CTR,DEPT CELLULAR & STRUCT BIOL,7703 FLOYD CURL DR,SAN ANTONIO,TX 78284. USA,INST SURG RES,FT SAM HOUSTON,TX 78234. NR 32 TC 4 Z9 4 U1 0 U2 0 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0028-3835 J9 NEUROENDOCRINOLOGY JI Neuroendocrinology PD DEC PY 1991 VL 54 IS 6 BP 629 EP 634 DI 10.1159/000125970 PG 6 WC Endocrinology & Metabolism; Neurosciences SC Endocrinology & Metabolism; Neurosciences & Neurology GA GT451 UT WOS:A1991GT45100014 PM 1784346 ER PT J AU XIE, JG RUEKGAUER, TE GU, J ARMSTRONG, RL PINNICK, RG PENDLETON, JD AF XIE, JG RUEKGAUER, TE GU, J ARMSTRONG, RL PINNICK, RG PENDLETON, JD TI PHYSICAL BASIS FOR DESCARTES RING SCATTERING IN LASER-IRRADIATED MICRODROPLETS SO OPTICS LETTERS LA English DT Article ID STIMULATED RAMAN-SCATTERING; DROPLET; DISTORTION AB Stimulated Raman scattering from laser-irradiated microdroplets is observed from two distinct spatial regions, the droplet rim and a ringlike region encircling the laser beam axis on the droplet shadow face (the Descartes ring). With the use of two pulsed laser beams, a perturbing beam and a delayed stimulated-Raman-scattering pump beam, the physical mechanism for Descartes ring scattering is investigated. Evidence is obtained of a persistent mechanism that continues even after the perturbing laser pulse is turned off. This mechanism is tentatively identified as electrostriction. The possible existence of an additional prompt mechanism that requires overlap between perturbing and pump laser pulses is also discussed. C1 ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002. RP XIE, JG (reprint author), NEW MEXICO STATE UNIV,DEPT PHYS,LAS CRUCES,NM 88003, USA. NR 11 TC 14 Z9 14 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD DEC 1 PY 1991 VL 16 IS 23 BP 1817 EP 1819 DI 10.1364/OL.16.001817 PG 3 WC Optics SC Optics GA GT347 UT WOS:A1991GT34700003 PM 19784148 ER PT J AU YU, FTS LI, Y YANG, X LU, T GREGORY, DA AF YU, FTS LI, Y YANG, X LU, T GREGORY, DA TI APPLICATION OF MOMENT INVARIANT PATTERN-RECOGNITION TO OPTICAL NEURAL NET SO OPTIK LA English DT Article ID NETWORK MODEL AB Shift, scale and rotation invariant pattern recognition using moment invariants is discussed in this paper. Calculated moment invariants are coded in binary forms, which are used to construct the associative memory in the neural network. The combination of moment invariants with optical neural network makes it possible to realize the distortion invariant pattern recognition. Shift and rotation invariances have been experimentally demonstrated with a low-cost LCTV optical neural network using the moment invariant principle. C1 USA,MISSILE COMMAND,REDSTONE ARSENAL,AL 35898. RP YU, FTS (reprint author), PENN STATE UNIV,DEPT ELECT & COMP ENGN,UNIV PK,PA 16802, USA. NR 14 TC 1 Z9 1 U1 0 U2 0 PU WISSENSCHAFTLICHE VERLAG MBH PI STUTTGART PA BIRKENWALDSTRASSE 44, POSTFACH 10 10 61, 70009 STUTTGART, GERMANY SN 0030-4026 J9 OPTIK JI Optik PD DEC PY 1991 VL 89 IS 2 BP 55 EP 58 PG 4 WC Optics SC Optics GA GW803 UT WOS:A1991GW80300002 ER PT J AU SNYDER, AP LIEBMAN, SA BULUSU, S SCHROEDER, MA FIFER, RA AF SNYDER, AP LIEBMAN, SA BULUSU, S SCHROEDER, MA FIFER, RA TI CHARACTERIZATION OF CYCLOTETRAMETHYLENETRANITRAMINE (HMX) THERMAL-DEGRADATION BY ISOTOPE ANALYSES WITH ANALYTICAL PYROLYSIS ATMOSPHERIC-PRESSURE IONIZATION TANDEM MASS-SPECTROMETRY SO ORGANIC MASS SPECTROMETRY LA English DT Article ID CHEMICAL IONIZATION; CYCLOTRIMETHYLENETRINITRAMINE RDX; TRIPLE QUADRUPOLES; BIO-POLYMERS; EXPLOSIVES; IDENTIFICATION; PRODUCTS; OCTAHYDRO-1,3,5,7-TETRANITRO-1,3,5,7-TETRAZOCINE; DECOMPOSITION; FRAGMENTATION AB Analytical pyrolysis-atmospheric pressure ionization (Py-API) tandem mass spectrometry was used in the structure elucidation of the oxidative and non-oxidative thermal decomposition products of cyclotetramethylenetetranitramine (HMX). The [(NO2)-N-15]-, [N-15(8))]- and [H-2(8)]-HMX isotope preparations provided fundamental information in the determination of the identities of the various pyrolyzate species. All RDX pyrolysis product ions that were identified by Py-API tandem mass spectrometry, i.e. m/z 44, 60, 74, 75, 85 and 98, were present in the pyrolyzate of HMX. In both RDX and HMX investigations, these ions provided identical mass spectral daughter ion analyses. HMX, however, provided additional ions at m/z 30, 58, 69, 71, 83 and 141. Of all thirteen ions identified in the Py-API mass spectrum of HMX, only that at m/z 75 contained a nitrogen atom that originated from the NO2 group. Standards analysis confirmed the identities of the ions at m/z 69, 71 and 141 as methyleneaminoacetonitrile, methylaminoacetonitrile and the caged compound hexamethylenetetraamine, respectively. Isotopic analyses provided a high degree of confidence on the structural assignments of the ions at m/z 30 and 58 as methyleneimine and methyleneformamide; the ion at m/z 83, however, appeared to be a heterocyclic compound with daughter ion mass spectral elements similar to but not identical with that of 1-methylimidazole and 3-methylpyrazole. C1 USA,BALLIST RES LAB,SLCBR,IB-I,ABERDEEN PROVING GROUND,MD 21005. USA,CTR ARMAMENT RES DEV & ENGN,PICATINNY ARSENAL,DOVER,NJ 07806. RP SNYDER, AP (reprint author), USA,CTR CHEM RES DEV & ENGN,SMCCR,RSL,ABERDEEN PROVING GROUND,MD 21010, USA. NR 26 TC 8 Z9 8 U1 1 U2 1 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0030-493X J9 ORG MASS SPECTROM JI Org. Mass Spectrom. PD DEC PY 1991 VL 26 IS 12 BP 1109 EP 1118 DI 10.1002/oms.1210261215 PG 10 WC Chemistry, Organic; Spectroscopy SC Chemistry; Spectroscopy GA GV102 UT WOS:A1991GV10200013 ER PT J AU ELLEDGE, ES WHIDDON, RG FRAKER, JT STAMBAUGH, KI AF ELLEDGE, ES WHIDDON, RG FRAKER, JT STAMBAUGH, KI TI THE EFFECTS OF TOPICAL ORAL CLINDAMYCIN ANTIBIOTIC RINSES ON THE BACTERIAL CONTENT OF SALIVA ON HEALTHY-HUMAN SUBJECTS SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article ID 2 3RD-GENERATION CEPHALOSPORINS; NECK-SURGERY; DOUBLE-BLIND; HEAD; PROPHYLAXIS; CEFAZOLIN; EFFICACY; CANCER AB The use of systemic antibiotics for major head and neck surgical procedures involving the upper aerodigestive tract is now accepted as an important part of perioperative patient care. Despite knowledge of the high counts of bacteria present in saliva, no preoperative regimen for preparing the mouth has been standardized. Surgical wounds come in contact with saliva during the course of many head and neck procedures. While wound infection rates have been decreased with the use of prophylactic systemic antibiotics, serious morbidity still exists from postoperative wound infections. Reducing the bacterial counts in saliva preoperatively may further decrease wound infection rates. A prospective randomized pilot study of twenty healthy human subjects compared the effects of an oral rinse with clindamycin vs. a placebo rinse of normal saline. There was a statistically significant reduction in both aerobic and anaerobic colony counts in the clindamycin group at 4 hours after treatment. For the group that rinsed with placebo, there was an actual increase in counts 4 hours after treatment. It is concluded that oral rinses with clindamycin can reduce the bacterial content of saliva for a sufficient length of time to be effective as a preoperative prophylactic measure for head and neck surgery involving the upper aerodigestive tract. Future studies are planned to evaluate other potentially effective agents. A logical continuation is a clinical study of preoperative and postoperative rinses. RP ELLEDGE, ES (reprint author), BROOKE ARMY MED CTR,DEPT SURG,OTOLARYNGOL SERV,FT SAM HOUSTON,TX 78234, USA. NR 12 TC 16 Z9 17 U1 1 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD DEC PY 1991 VL 105 IS 6 BP 836 EP 839 PG 4 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA GV802 UT WOS:A1991GV80200011 PM 1787974 ER PT J AU LOVIN, JD TALARICO, CL WEGERT, SL GAYNOR, LF SUTLEY, SS AF LOVIN, JD TALARICO, CL WEGERT, SL GAYNOR, LF SUTLEY, SS TI GORLIN SYNDROME WITH ASSOCIATED ODONTOGENIC CYSTS SO PEDIATRIC RADIOLOGY LA English DT Article ID CELL CARCINOMA; AMELOBLASTOMA; KERATOCYSTS AB Multiple maxillary and mandibular cysts are principle features of basal cell nevus syndrome (Gorlin-Goltz). We present cases from an affected family in which magnetic resonance imaging (MRI) was helpful in evaluation of the cystic lesions. A middle ear anomaly was identified which may represent an additional abnormality associated with the syndrome. C1 CHARLOTTE RADIOL GRP PA,CHARLOTTE,NC. RADIOL IMAGING ASSOCIATES,ENGLEWOOD,CO. FITZSIMONS ARMY MED CTR,DEPT RADIOL,AURORA,CO 80045. RP LOVIN, JD (reprint author), WOMACK ARMY MED CTR,DEPT RADIOL,FT BRAGG,NC 28309, USA. NR 14 TC 17 Z9 17 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0301-0449 J9 PEDIATR RADIOL JI Pediatr. Radiol. PD DEC PY 1991 VL 21 IS 8 BP 584 EP 587 DI 10.1007/BF02012604 PG 4 WC Pediatrics; Radiology, Nuclear Medicine & Medical Imaging SC Pediatrics; Radiology, Nuclear Medicine & Medical Imaging GA HC567 UT WOS:A1991HC56700013 PM 1815182 ER PT J AU FINE, BJ MCCORD, L AF FINE, BJ MCCORD, L TI ORAL-CONTRACEPTIVE USE, CAFFEINE CONSUMPTION, FIELD-DEPENDENCE, AND THE DISCRIMINATION OF COLORS SO PERCEPTUAL AND MOTOR SKILLS LA English DT Article ID MUNSELL 100-HUE TEST; SENSITIVITY; ABILITY; MEN AB We attempted to validate laboratory research which indicated that single doses of oral contraceptives (OCs) and caffeine affect the ability to discriminate colors (Bohme & Bohme, 1985). We did this in a nonlaboratory setting by surveying habitual use of OCs and caffeine by 43 female college students and relating that information to their performance on the Farnsworth-Munsell 100-Hue Test. When field-dependence, conceptualized as an indirect measure of sensitivity of the nervous system and previously shown to be strongly related to color discrimination, was included in the analyses, the results supported Bohme and Bohme's findings. For Trays 2 and 3 of the 100-Hue Test (yellow through blue of the color spectrum), higher caffeine consumption among OC users was related to poorer color discrimination, whereas, among nonusers of OCs, it was related to better performance. Study design limitations do not permit attribution of causation to either caffeine or OCs at this time. C1 WELLESLEY COLL,WELLESLEY,MA 02181. RP FINE, BJ (reprint author), USA,ENVIRONM MED RES INST,NATICK,MA 01760, USA. NR 24 TC 2 Z9 2 U1 0 U2 4 PU PERCEPTUAL MOTOR SKILLS PI MISSOULA PA PO BOX 9229, MISSOULA, MT 59807 SN 0031-5125 J9 PERCEPT MOTOR SKILL JI Percept. Mot. Skills PD DEC PY 1991 VL 73 IS 3 BP 931 EP 941 PN 1 PG 11 WC Psychology, Experimental SC Psychology GA GX306 UT WOS:A1991GX30600042 PM 1792144 ER PT J AU MAEL, FA AF MAEL, FA TI A CONCEPTUAL RATIONALE FOR THE DOMAIN AND ATTRIBUTES OF BIODATA ITEMS SO PERSONNEL PSYCHOLOGY LA English DT Article ID BIOGRAPHICAL INFORMATION BLANK; PERSON-SITUATION DEBATE; SELECTION; SELF; VALIDITY; CONSTRUCTS; RESPONSES; ACCURACY; BEHAVIOR; ITEM AB There is considerable disagreement among researchers regarding the defining attributes of biodata items, especially in contrast to other self-report measures. This paper provides a conceptual rationale for the use of biodata in order to evaluate various proposed attributes of biodata, and to clarify similarities and differences between biodata and temperament items. It is suggested that the core attribute of biodata items is that the items pertain to historical events that may have shaped the person's behavior and identity. Other attributes advanced as antidotes to socially desirable responding and faking are that biodata items reflect external events, that they be limited to objective and first-hand recollections, that they be potentially verifiable, and that they measure discrete, unique events when appropriate. Some researchers also require that the life events being sampled be controllable and equally accessible to all respondents. Items may also need to be visibly job relevant and nonintrusive to avoid legal censure. Disagreements among researchers regarding the importance of these attributes are discussed, and implications for practice and research are proposed. RP MAEL, FA (reprint author), USA,RES INST,5001 EISENHOWER AVE,ALEXANDRIA,VA 22333, USA. NR 98 TC 84 Z9 85 U1 2 U2 16 PU PERSONNEL PSYCHOLOGY INC PI BOWLING GREEN PA 745 HASKINS ROAD, SUITE A, BOWLING GREEN, OH 43402 SN 0031-5826 J9 PERS PSYCHOL JI Pers. Psychol. PD WIN PY 1991 VL 44 IS 4 BP 763 EP 792 PG 30 WC Psychology, Applied; Management SC Psychology; Business & Economics GA GW064 UT WOS:A1991GW06400003 ER PT J AU BRUECKNER, RP FLECKENSTEIN, L AF BRUECKNER, RP FLECKENSTEIN, L TI SIMULTANEOUS MODELING OF THE PHARMACOKINETICS AND METHEMOGLOBIN PHARMACODYNAMICS OF AN 8-AMINOQUINOLINE CANDIDATE ANTIMALARIAL (WR 238605) SO PHARMACEUTICAL RESEARCH LA English DT Article DE 8-AMINOQUINOLINE; ANTIMALARIAL; CYANIDE POISONING; METHEMOGLOBIN; PHARMACOKINETIC-PHARMACODYNAMIC MODEL ID MALARIA AB Methemoglobin (MHb) formation can be a clinically significant and dose-limiting side effect of 8-aminoquinoline antimalarials. MHb may also protect against cyanide poisoning. A two-compartment pharmacokinetic model, linked to a sigmoid E(max) pharmacodynamic model, was developed to predict the MHb levels after administration of 8-[(4-amino-1-methylbutyl)amino]-2,6-dimethoxy-4-methyl-5-[(3-trifluoromethyl)phenoxyl] quinoline succinate (WR 238605 succinate), a primaquine analogue. Six healthy male beagle dogs received four daily doses of 6.0 mg/kg (base) orally. Forty plasma drug concentrations and 19 MHb levels (effect) were determined over 7 weeks on each dog. Compartmental and noncompartmental pharmacokinetic and parametric and nonparametric pharmacodynamic analyses were performed. Model parameters (mean +/- SD) included a V(ss)/f of 18.5 +/- 2.8 L/kg, CL/f of 83 +/- 24 ml/hr/kg, terminal elimination t1/2 of 169.7 +/- 52.0 hr, t1/2k(eo) of 123.0 +/- 22.4 hr, an E(max) of 31.3 +/- 15.9% MHb, an EC50 of 596 +/- 128 ng/ml, and a sigmoidicity coefficient (n) of 1.94 +/- 0.47. The model was then validated in three additional dogs given three different dosing regimens. It predicted the peak plasma concentrations and MHb levels and the times of their occurrence well. This model could be useful for dose and sampling time selection in further animal studies and initial human phase I clinical testing. RP BRUECKNER, RP (reprint author), WALTER REED ARMY MED CTR,DEPT PHARMACOL,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. OI Fleckenstein, Lawrence/0000-0001-5320-4531 NR 18 TC 14 Z9 14 U1 0 U2 1 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0724-8741 J9 PHARMACEUT RES JI Pharm. Res. PD DEC PY 1991 VL 8 IS 12 BP 1505 EP 1510 DI 10.1023/A:1015842316177 PG 6 WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy SC Chemistry; Pharmacology & Pharmacy GA GR831 UT WOS:A1991GR83100009 PM 1808614 ER PT J AU LITTLEFIELD, DL AF LITTLEFIELD, DL TI ENHANCEMENT OF STABILITY IN UNIFORMLY ELONGATING PLASTIC JETS WITH ELECTROMAGNETIC-FIELDS SO PHYSICS OF FLUIDS A-FLUID DYNAMICS LA English DT Article AB The stability of rapidly stretching, perfectly plastic jets when subjected to axial magnetic fields is studied in this analysis. The jet is assumed to be uniformly elongating, infinitely long, and isothermal. An axial magnetic field, assumed to be provided by a solenoid in the surrounding vacuum, is initiated at time t = 0. Linear perturbation theory is employed to calculate the time evolution of small disturbances in the jet. Results of the calculations indicate that imposed axial magnetic fields inhibit the growth rates of instabilities in the jet. Entrained magnetic fields, however, are present after the jet leaves the solenoid, and increase the growth rates of disturbances. As a consequence, the overall growth rates are strongly dependent on the magnetic Reynolds number. This result is explained in terms of the applicable magnetohydrodynamic (MHD) stability mechanisms in the jet. C1 USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005. RP LITTLEFIELD, DL (reprint author), SW RES INST,PO DRAWER 28510,SAN ANTONIO,TX 78228, USA. NR 11 TC 4 Z9 6 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0899-8213 J9 PHYS FLUIDS A-FLUID PD DEC PY 1991 VL 3 IS 12 BP 2927 EP 2935 DI 10.1063/1.857835 PG 9 WC Mechanics; Physics, Fluids & Plasmas SC Mechanics; Physics GA GT358 UT WOS:A1991GT35800010 ER PT J AU DIECKMANN, GS LANGE, MA ACKLEY, SF JENNINGS, JC AF DIECKMANN, GS LANGE, MA ACKLEY, SF JENNINGS, JC TI THE NUTRIENT STATUS IN SEA ICE OF THE WEDDELL SEA DURING WINTER - EFFECTS OF SEA ICE TEXTURE AND ALGAE SO POLAR BIOLOGY LA English DT Article ID MICROBIAL COMMUNITIES; ANTARCTIC PHYTOPLANKTON; MCMURDO SOUND; HUDSON-BAY; ROSS SEA; MICROALGAE; DIATOMS; LIGHT; ASSIMILATION; ASSEMBLAGES AB Cores and brine samples from sea ice of the Weddell Sea were analyzed for nutrients (phosphate, nitrate and silicate), salinity and chlorophyll a during winter. Stratigraphic analyses of the cores were also carried out. Bulk nutrient concentrations in the sea ice fluctuated widely and did not correlate with salinity. Nutrient concentrations in cores were normalized to seawater salinity to facilitate comparison. They varied between zero and two or three times those measured in the water column. Differentiation into young and old sea ice, however, revealed that nutrient concentrations in the young ice in many cases corresponded to those in surface seawater. In older ice, nutrients showed signs of increase as well as depletion or exhaustion relative to the water column. Differentiation of core sections according to ice textural classes and analyses of brine samples clarified some relationships between nutrients, salinity and algal biomass. Most of the changes in the nutrient concentrations are attributed to an increase in biological activity as the seasons progress. Silicate is expected to become the first nutrient likely to limit growth of diatoms in the ice which is ascribed to slower regeneration or dissolution of this nutrient relative to phosphate and nitrate. A consequence of silicate exhaustion may be the succession of different algal assemblages, from a diatom dominated community to one in which autotrophic flagellates form the largest component. C1 USA,COLD REG RES & ENGN LAB,HANOVER,NH 03765. OREGON STATE UNIV,CORVALLIS,OR 97331. UNIV SO CALIF,LOS ANGELES,CA 90089. RP DIECKMANN, GS (reprint author), ALFRED WEGENER,INST POLAR & MEERESFORSCH,COLUMBUSSTR,W-2850 BREMERHAVEN,GERMANY. RI Dieckmann, Gerhard/B-4307-2010 NR 59 TC 70 Z9 78 U1 0 U2 6 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0722-4060 J9 POLAR BIOL JI Polar Biol. PD DEC PY 1991 VL 11 IS 7 BP 449 EP 456 PG 8 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA GU478 UT WOS:A1991GU47800005 ER PT J AU KRONICK, P AF KRONICK, P TI PROVIDING FLOOD PROTECTION TO THE PASSAIC RIVER BASIN RESPONSE TO FILIPPONE,ELLA, PASSAIC RIVER COALITION SO POPULATION AND ENVIRONMENT LA English DT Article RP KRONICK, P (reprint author), USA,CORPS ENGN,PASSAIC RIVER DIV,80 RIVER ST,HOBOKEN,NJ 07030, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU HUMAN SCI PRESS INC PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013-1578 SN 0199-0039 J9 POPUL ENVIRON JI Popul. Env. PD WIN PY 1991 VL 13 IS 2 BP 141 EP 147 DI 10.1007/BF01255516 PG 7 WC Demography; Environmental Studies SC Demography; Environmental Sciences & Ecology GA HM746 UT WOS:A1991HM74600006 ER PT J AU MOUL, JW AF MOUL, JW TI GYNECOMASTIA AND EXTRAGONADAL SYMPTOMS LEADING TO DIAGNOSIS DELAY OF GERM-CELL TUMORS IN YOUNG MEN SO POSTGRADUATE MEDICAL JOURNAL LA English DT Letter ID SURVIVAL C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP MOUL, JW (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU BRITISH MED JOURNAL PUBL GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON, ENGLAND WC1H 9JR SN 0032-5473 J9 POSTGRAD MED J JI Postgrad. Med. J. PD DEC PY 1991 VL 67 IS 794 BP 1082 EP 1082 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA GX977 UT WOS:A1991GX97700014 PM 1666188 ER PT J AU LINTHICUM, KJ BAILEY, CL TUCKER, CJ ANGLEBERGER, DR CANNON, T LOGAN, TM GIBBS, PH NICKESON, J AF LINTHICUM, KJ BAILEY, CL TUCKER, CJ ANGLEBERGER, DR CANNON, T LOGAN, TM GIBBS, PH NICKESON, J TI TOWARDS REAL-TIME PREDICTION OF RIFT-VALLEY FEVER EPIDEMICS IN AFRICA SO PREVENTIVE VETERINARY MEDICINE LA English DT Article ID KENYA; HABITATS AB Outbreaks of Rift Valley fever (RVF) virus in Africa are characterized by distinct spatial and temporal patterns that are directly related to specific environmental parameters associated with mosquito vectors that function in the maintenance (endemic) and transmission (epizootic) cycles of the virus. National Oceanic and Atmospheric Administration (NOAA) satellites with limited resolution (1 km) can indirectly measure rainfall inexpensively over subcontinental or continental areas at a high temporal frequency, and identify regions with a high potential for viral activity. Within regions of likely viral activity, mosquito vector-breeding habitats (dambos) are identified and mapped with archived, high-quality, cloud-free, higher resolution data from LANDSAT (thematic mapper resolution 30 m) and SPOT (multispectral resolution 20 m) satellites. Active sensors, like airborne synthetic aperture radar systems (range resolution 1.6 m), are capable of detecting flooded habitats' even through cloud cover. By identifying flooded habitats within regions with a high likelihood of RVF activity, the potential source foci of an outbreak may be detected close to real-time and control efforts implemented prior to the start of a RVF epidemic/epizootic. C1 NASA,GODDARD SPACE FLIGHT CTR,GREENBELT,MD 20771. RP LINTHICUM, KJ (reprint author), USA,MED RES INST INFECT DIS,DIV VIROL,DEPT ARBOVIRAL ENTOMOL,FT DETRICK,FREDERICK,MD 21701, USA. NR 12 TC 21 Z9 22 U1 1 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-5877 J9 PREV VET MED JI Prev. Vet. Med. PD DEC PY 1991 VL 11 IS 3-4 BP 325 EP 334 DI 10.1016/S0167-5877(05)80019-4 PG 10 WC Veterinary Sciences SC Veterinary Sciences GA GW988 UT WOS:A1991GW98800019 ER PT J AU MCDONNELL, J AF MCDONNELL, J TI CONTROLLING THE ATOM - THE BEGINNINGS OF NUCLEAR-REGULATION, 1946-1962 - MAZUZAN,GT, WALKER,JS SO PUBLIC HISTORIAN LA English DT Book Review RP MCDONNELL, J (reprint author), US ARMY CORPS ENGINEERS,HIST OFF,ROCK ISL,IL, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU UNIV CALIF PRESS PI BERKELEY PA JOURNALS DEPT 2120 BERKELEY WAY, BERKELEY, CA 94720 SN 0272-3433 J9 PUBL HISTORIAN JI Public Hist. PD WIN PY 1991 VL 13 IS 1 BP 109 EP 111 PG 3 WC History SC History GA FG517 UT WOS:A1991FG51700029 ER PT J AU FAMINI, GR KASSEL, RJ KING, JW WILSON, LY AF FAMINI, GR KASSEL, RJ KING, JW WILSON, LY TI USING THEORETICAL DESCRIPTORS IN QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS - COMPARISON WITH THE MOLECULAR TRANSFORM SO QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS LA English DT Article DE TLSER; LSER; MOLECULAR TRANSFORM; MOLECULAR ORBITAL THEORY; MNDO ID SOLVATION ENERGY RELATIONSHIPS; LOCAL EMPIRICAL RULES; FUNDAMENTAL LAWS; PI-STAR; CHEMOMETRICIANS; PARAMETERS; CHEMISTRY; ALPHA; BETA AB A variety of techniques and methodologies are currently being used in quantitative structure-activity relationships (QSAR). A major difficulty with past relationships has been the use of a parameter sets which cannot be applied uniformly to a wide range of properties and data sets. The development of the Linear Solvation Energy Relationship by Kamlet and Taft, and our development of the Theoretical Linear Solvation Energy Relationship (TLSER) have attempted to overcome this principal difficulty by employing a standard parameter set for every correlation. Another methodology that has also proven successful in this regard is the use of topological indices to correlate a variety of properties. This paper compares the TLSER with one such index, the molecular transform. In addition, we show the high correlative capability of the TLSER methodology with the minimum blocking concentration for a set of 36 local anesthetics. C1 LOMA LINDA UNIV,DEPT CHEM,RIVERSIDE,CA 92515. RP FAMINI, GR (reprint author), USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010, USA. NR 32 TC 34 Z9 34 U1 1 U2 1 PU VCH PUBLISHERS INC PI DEERFIELD BEACH PA 303 NW 12TH AVE, DEERFIELD BEACH, FL 33442-1788 SN 0931-8771 J9 QUANT STRUCT-ACT REL JI Quant. Struct.-Act. Relat. PD DEC PY 1991 VL 10 IS 4 BP 344 EP 349 DI 10.1002/qsar.19910100406 PG 6 WC Chemistry, Medicinal; Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA HC343 UT WOS:A1991HC34300005 ER PT J AU HALL, DK STURM, M BENSON, CS CHANG, ATC FOSTER, JL GARBEIL, H CHACHO, E AF HALL, DK STURM, M BENSON, CS CHANG, ATC FOSTER, JL GARBEIL, H CHACHO, E TI PASSIVE MICROWAVE REMOTE AND INSITU MEASUREMENTS OF ARCTIC AND SUB-ARCTIC SNOW COVERS IN ALASKA SO REMOTE SENSING OF ENVIRONMENT LA English DT Article ID WATER EQUIVALENT; SATELLITE DATA; SMMR DATA; RADIOMETER; DEPTH AB Between 11 and 19 March 1988, airborne and satellite passive microwave measurements were acquired simultaneously with ground measurements of depth, density and stratigraphy of the snow in central and northern Alaska. Five aircraft flights were flown along a north-south transect between about 147-degrees-W and 152-degrees-W, and extending from about 63-degrees-N (south of Fairbanks, Alaska) to the Arctic Ocean coastline, with an Aircraft Multichannel Microwave Radiometer (AMMR) on-board operating at 92 GHz, 37 GHz, 21 GHz, and 18 GHz. Passive microwave data from the satellite-borne Special Sensor Microwave Imager (SSMI), operating at 85.5 GHz, 37 GHz, 21 GHz, 18 GHz, and 10 GHz, were obtained concurrently. A good correspondence in brightness temperature (T(B)) trends between the aircraft and satellite data was found. However, an expected inverse correlation between depth hoar thickness and T(B) was not found to be strong. A persistent T(B) minimum in both the aircraft and the satellite data was detected along the northern foothills of the Brooks Range. In an area located at about 68-degrees-50'N, 149-degrees-20'W, the T(B) as recorded from the aircraft microwave sensor dropped by 55 K Satellite microwave measurements showed a T(B) decrease of up to 45 K at approximately the same location. Snow pit measurements did not reveal notable differences in snow characteristics or depth in this location. examination of passive microwave satellite data from 1978 to 1987 revealed that similar low late-winter T(B) values were found in approximately the same locations as those observed in March 1988. According to the satellite data, the zone of low T(B) develops as the snow deepens, and reaches the lowest values in March or April each year. The cause of this T(B) minimum is unknown but thought to be related to snow stratigraphy. The observed difficulty in relating the ground measurements to data collected using aircraft and satellite passive microwave sensors is attributed to the fact that the snow depth and character are highly variable in central and northern Alaska. This variability is exemplified in the field measurements as well as in the passive microwave measurements. C1 COLD REG RES & ENGN LAB,FAIRBANKS,AK. UNIV ALASKA,INST GEOPHYS,FAIRBANKS,AK 99701. UNIV HAWAII,HAWAII INST GEOPHYS,DIV PLANETARY GEOSCI,HONOLULU,HI 96822. RP HALL, DK (reprint author), NASA,GODDARD SPACE FLIGHT CTR,HYDROL SCI BRANCH,CODE 974,GREENBELT,MD 20771, USA. RI Hall, Dorothy/D-5562-2012 NR 46 TC 46 Z9 53 U1 1 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0034-4257 J9 REMOTE SENS ENVIRON JI Remote Sens. Environ. PD DEC PY 1991 VL 38 IS 3 BP 161 EP 172 DI 10.1016/0034-4257(91)90086-L PG 12 WC Environmental Sciences; Remote Sensing; Imaging Science & Photographic Technology SC Environmental Sciences & Ecology; Remote Sensing; Imaging Science & Photographic Technology GA GY484 UT WOS:A1991GY48400001 ER PT J AU PERSSON, AV DAVIS, RJ VILLAVICENCIO, JL AF PERSSON, AV DAVIS, RJ VILLAVICENCIO, JL TI DEEP VENOUS THROMBOSIS AND PULMONARY-EMBOLISM SO SURGICAL CLINICS OF NORTH AMERICA LA English DT Article ID VEIN-THROMBOSIS; SUBCUTANEOUS HEPARIN; PREVENTION; THROMBOEMBOLISM; DIAGNOSIS; COMPRESSION; PROPHYLAXIS; SURGERY; TRIALS C1 HARVARD UNIV,SCH MED,BOSTON,MA 02115. BOSTON UNIV,SCH MED,BOSTON,MA 02118. UNIFORMED SERV UNIV HLTH SCI,SURG,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,VENOUS & LYMPHAT SURG CLIN,WASHINGTON,DC 20307. RP PERSSON, AV (reprint author), LAHEY CLIN MED CTR,PERIPHERAL VASC SURG SECT,41 MALL RD,BURLINGTON,MA 01805, USA. NR 39 TC 27 Z9 27 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0039-6109 J9 SURG CLIN N AM JI Surg. Clin.-North Am. PD DEC PY 1991 VL 71 IS 6 BP 1195 EP 1209 PG 15 WC Surgery SC Surgery GA JD277 UT WOS:A1991JD27700006 PM 1948569 ER PT J AU MAZUR, AW THOMPSON, IM AF MAZUR, AW THOMPSON, IM TI EFFICACY AND MORBIDITY OF CHANNEL TURP SO UROLOGY LA English DT Article ID TRANS-URETHRAL RESECTION; PROSTATE-CANCER AB Transurethral resection of the prostate (TURP) is necessary in a significant proportion of men with a diagnosis of carcinoma of the prostate. Often, "channel" TURP (resection of visually obstructing tissue without extension to the prostatic capsule in a patient with metastatic or locally advanced disease to improve voiding symptoms) is required. Although several theoretical concerns regarding the efficacy and morbidity of this procedure have been voiced, data to support these contentions are lacking. In a review of 41 patients undergoing channel TURP, all were able to void following the procedure. Two patients in whom the resection was carried through the external urinary sphincter, which had been invaded by tumor, were incontinent postoperatively. Two patients had mild stress incontinence. There were no perioperative deaths. These data suggest that incontinence is higher than expected with TURP for benign disease but that results may be acceptable to the patient with significant outlet obstructive symptoms. C1 JOINT MIL MED COMMAND,BROOKE ARMY MED CTR,UROL SERV,SAN ANTONIO,TX. RP THOMPSON, IM (reprint author), BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234, USA. NR 9 TC 29 Z9 37 U1 0 U2 0 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0090-4295 J9 UROLOGY JI UROLOGY PD DEC PY 1991 VL 38 IS 6 BP 526 EP 528 DI 10.1016/0090-4295(91)80170-C PG 3 WC Urology & Nephrology SC Urology & Nephrology GA GU288 UT WOS:A1991GU28800006 PM 1746080 ER PT J AU MANDL, CW IACONOCONNORS, L WALLNER, G HOLZMANN, H KUNZ, C HEINZ, FX AF MANDL, CW IACONOCONNORS, L WALLNER, G HOLZMANN, H KUNZ, C HEINZ, FX TI SEQUENCE OF THE GENES ENCODING THE STRUCTURAL PROTEINS OF THE LOW-VIRULENCE TICK-BORNE FLAVIVIRUSES LANGAT TP21 AND YELANTSEV SO VIROLOGY LA English DT Note ID VIRUS WESTERN SUBTYPE; ENCEPHALITIS-VIRUS; ENVELOPE PROTEIN; MONOCLONAL-ANTIBODIES; NUCLEOTIDE-SEQUENCE; MODEL; GLYCOPROTEIN; GENOME C1 USA,MED RES INST INFECT DIS,DIV VIROL,FREDERICK,MD 21701. RP MANDL, CW (reprint author), UNIV VIENNA,INST VIROL,KINDERSPITALGASSE 15,A-1095 VIENNA,AUSTRIA. NR 26 TC 41 Z9 45 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0042-6822 J9 VIROLOGY JI Virology PD DEC PY 1991 VL 185 IS 2 BP 891 EP 895 DI 10.1016/0042-6822(91)90567-U PG 5 WC Virology SC Virology GA GR867 UT WOS:A1991GR86700046 PM 1720591 ER PT J AU EHLEN, J AF EHLEN, J TI SIGNIFICANT GEOMORPHIC AND PETROGRAPHIC RELATIONS WITH JOINT SPACING IN THE DARTMOOR GRANITE, SOUTHWEST ENGLAND SO ZEITSCHRIFT FUR GEOMORPHOLOGIE LA English DT Article ID BORNHARDTS AB Horizontal and vertical joint spacing frequency distributions were compared using statistical analysis with respect to joint type, landform type, relative relief, rock texture and rock grain size in the Dartmoor granite. Joint spacing distributions are significantly different for each type of tor, with mean joint spacing increasing in the order pinnacle, valleyside, spur, and summit. Other important significant relations are those among tor type, relative relief and number of megacrysts. A model for the evolution of the Dartmoor tors, based on analysis of joint spacing distributions, is proposed. Successful, albeit limited, tests of the model show that joint spacing relations can restrict landform evolution in granitic rocks. Evolution is restricted such that valleyside tors evolve only into pinnacles; spur tors evolve into either valleyside tors or pinnacles; summit tors evolve into either spur tors or pinnacles; and pinnacles evolve into boulder piles. RP EHLEN, J (reprint author), USA,TOPOG ENGN CTR RES INST,DIV REMOTE SENSING,FT BELVOIR,VA 22060, USA. NR 18 TC 7 Z9 7 U1 0 U2 2 PU GEBRUDER BORNTRAEGER PI STUTTGART PA JOHANNESSTR 3A, D-70176 STUTTGART, GERMANY SN 0372-8854 J9 Z GEOMORPHOL JI Z. Geomorphol. PD DEC PY 1991 VL 35 IS 4 BP 425 EP 438 PG 14 WC Geography, Physical; Geosciences, Multidisciplinary SC Physical Geography; Geology GA GW659 UT WOS:A1991GW65900003 ER PT J AU BURCH, HB NAGY, EV LUKES, YG CAI, WY WARTOFSKY, L BURMAN, KD AF BURCH, HB NAGY, EV LUKES, YG CAI, WY WARTOFSKY, L BURMAN, KD TI NUCLEOTIDE AND AMINO-ACID HOMOLOGY BETWEEN THE HUMAN THYROTROPIN RECEPTOR AND THE HIV-1 NEF PROTEIN - IDENTIFICATION AND FUNCTIONAL-ANALYSIS SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS LA English DT Article ID ANTIBODIES; SEQUENCE; INDIVIDUALS; EXPRESSION; CLONING C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. RP BURCH, HB (reprint author), WALTER REED ARMY MED CTR,DEPT MED,ENDOCRINE METAB SERV,KYLE METAB UNIT,WASHINGTON,DC 20307, USA. FU FIC NIH HHS [1 F 05 TW04412-01] NR 21 TC 33 Z9 33 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0006-291X J9 BIOCHEM BIOPH RES CO JI Biochem. Biophys. Res. Commun. PD NOV 27 PY 1991 VL 181 IS 1 BP 498 EP 505 DI 10.1016/S0006-291X(05)81447-0 PG 8 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA GR961 UT WOS:A1991GR96100075 PM 1958218 ER PT J AU FULLER, KA AF FULLER, KA TI OPTICAL RESONANCES AND 2-SPHERE SYSTEMS SO APPLIED OPTICS LA English DT Article DE SCATTERING; RESONANCES; PARTICLES ID CLASSICAL ELECTROMAGNETIC SCATTERING; 2 DIELECTRIC SPHERES; LIGHT-SCATTERING; CONSUMMATE SOLUTION; WAVE SCATTERING; LIQUID DROPLETS; CYLINDERS; ABSORPTION; PARTICLE; ENSEMBLE AB After a historical review of previous research into cooperative scattering, a theoretical investigation of the effects of interparticle coupling on morphology-dependent resonances of spheres is conducted. Bispheres composed of identical, slightly dissimilar, and very different monomers are considered. Calculations are presented of resonance spectra for selected orientations of the bispheres relative to the incident wave vector along with spectra that should prove useful in describing the scattering properties of a monodisperse ensemble of randomly oriented bispheres. (The bispheres in this dispersion may be constituted from dissimilar monomers.) Normalized source functions for regions inside and near the scatterers are also provided. Finally a numerical simulation of an interesting experiment is carried out in which a resonating aerosol passes through the focal volume of a relatively large, spherical microlens. C1 ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002. NR 52 TC 112 Z9 114 U1 0 U2 7 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD NOV 20 PY 1991 VL 30 IS 33 BP 4716 EP 4731 PG 16 WC Optics SC Optics GA GX449 UT WOS:A1991GX44900007 PM 20717274 ER PT J AU MARSHALL, MS BENNER, RE AF MARSHALL, MS BENNER, RE TI SPHERICAL-PARTICLE SIZING BASED ON THE VANDERLUGT CORRELATOR SO APPLIED OPTICS LA English DT Article ID COUNTERS AB We present a flexible architecture for particle sizing based on the VanderLugt correlator with a multiplexed matched spatial filter. Theoretical and experimental data obtained using opaque spherical particle projections demonstrate the potential uses and simplicity of the architecture. The system is capable of handling spherical and nonspherical particles and shows potential for handling high particle concentrations. C1 UNIV UTAH, DEPT ELECT ENGN, INST LASER, SALT LAKE CITY, UT 84112 USA. RP MARSHALL, MS (reprint author), USA, INSTRUMENTAT BRANCH, DUGWAY PROVING GROUND, DUGWAY PROVING GROUND, UT 84022 USA. NR 13 TC 7 Z9 7 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD NOV 20 PY 1991 VL 30 IS 33 BP 4848 EP 4853 PG 6 WC Optics SC Optics GA GX449 UT WOS:A1991GX44900021 PM 20717288 ER PT J AU SQUIRE, EN HUSS, K HUSS, R AF SQUIRE, EN HUSS, K HUSS, R TI WHERE THERES SMOKE THERE ARE LIARS SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Letter RP SQUIRE, EN (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD NOV 20 PY 1991 VL 266 IS 19 BP 2702 EP 2702 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA GP691 UT WOS:A1991GP69100014 PM 1942418 ER PT J AU KELLEY, PW PETRUCCELLI, BP STEHRGREEN, P ERICKSON, RL MASON, CJ AF KELLEY, PW PETRUCCELLI, BP STEHRGREEN, P ERICKSON, RL MASON, CJ TI THE SUSCEPTIBILITY OF YOUNG-ADULT AMERICANS TO VACCINE-PREVENTABLE INFECTIONS - A NATIONAL SEROSURVEY OF UNITED-STATES-ARMY RECRUITS SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID LINKED IMMUNOSORBENT-ASSAY; VARICELLA-ZOSTER VIRUS; EPIDEMIC MEASLES; RUBELLA; POPULATION; IMMUNIZATION; ANTIBODY; MUMPS AB Objective. - Due to recent resurgences of measles, mumps, and rubella among young US adults, we sought to generate antibody prevalence data for national and military immunization policy evaluations. Design. - We used a questionnaire and serological survey of Army recruits to assess antibody status to measles, mumps, rubella, and varicella by enzyme-linked immunosorbent assay and to poliovirus types 1, 2, and 3 by microneutralization assay. Setting. - Basic training reception centers at Fort Benning, Ga, and Fort Jackson, SC. Patients. - The study included 1547 US Army recruits who were inducted during September and October 1989. Outcome Measures. - Seronegativity by various demographic factors. Results. - Seronegativity rates, directly adjusted to the 15- to 24-year-old US population in 1980, were 20.7% for measles, 15.6% for mumps, 17.5% for rubella, and 6.9% for varicella. For measles, mumps, and rubella, susceptibility was less in females, blacks, and college-educated recruits, and varicella susceptibility was greater in females and blacks. Recruits who were born after 1969 lacked measles, mumps, and rubella antibodies more often than older recruits. The adjusted seronegativity rates for poliovirus types 1, 2, and 3 were 2.3%, 0.6%, and 14.6%, respectively; trends by age, sex, and race-ethnicity were generally unremarkable. Conclusions. - Among young adult Americans, susceptibility to measles, mumps, and rubella is unevenly distributed and may be substantial. Our findings support national objectives to further improve immunization coverage in school-age and adult populations and provide further impetus for legislation requiring college entrants to present evidence of having received at least two doses of measles vaccine, with one on or after entry into elementary school. C1 CTR DIS CONTROL,CTR PREVENT SERV,DIV IMMUNIZAT,ATLANTA,GA 30333. RP KELLEY, PW (reprint author), WALTER REED ARMY MED CTR,DIV PREVENT MED,ADV PREVENT MED STUDIES BRANCH,WASHINGTON,DC 20307, USA. NR 42 TC 108 Z9 110 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD NOV 20 PY 1991 VL 266 IS 19 BP 2724 EP 2729 DI 10.1001/jama.266.19.2724 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA GP691 UT WOS:A1991GP69100028 PM 1942425 ER PT J AU HAMMOND, PS FORSTER, JS AF HAMMOND, PS FORSTER, JS TI A POLYMERIC AMINE COPPER(II) COMPLEX AS CATALYST FOR THE HYDROLYSIS OF 1,2,2-TRIMETHYLPROPYL METHYLPHOSPHONOFLUORIDATE (SOMAN) AND BIS(1-METHYLETHYL)PHOSPHOROFLUORIDATE (DFP) SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article ID ORGANO-PHOSPHORUS COMPOUNDS; PHOSPHATE; CLEAVAGE; ESTERS AB The Cu(II) complex of poly-4-vinylpyridine, quaternized with 19 mol % ethyl bromide and 36 mol % 4-chloromethyl-4'-methyl-2,2'-bipyridine, was examined as a catalyst for the hydrolysis of the toxic organophosphorous compounds bis (1-methylethyl) phosphorofluoridate (1, DFP) and 1,2,2-trimethylpropyl methylphosphonofluoridate (2, soman). Studies were carried out at 25.0 and 37.0-degrees-C for both substrates in MOPS buffer at pH 7.0. In the presence of 7.31 X 10(-3) M catalyst at 25.0-degrees-C, soman is hydrolyzed with a first-order rate constant of 0.019 min-1 (t1/2 = 37.5 min), whereas DFP hydrolyzes with a rate constant of 0.011 min-1 (t1/2 = 63.8 min). For soman, this represents a 14-fold increase over the uncatalyzed rate in the same buffer. Other studies examined the effect of a strongly sorptive polymeric resin on catalysis by this copper-containing polymer and found a dramatic de-crease in the hydrolysis rate of soman in the presence of the polymeric sorbent. RP HAMMOND, PS (reprint author), USA,MED RES INST CHEM DEF,BASIC ASSESSMENT BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 20 TC 12 Z9 12 U1 1 U2 2 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0021-8995 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD NOV 20 PY 1991 VL 43 IS 10 BP 1925 EP 1931 DI 10.1002/app.1991.070431017 PG 7 WC Polymer Science SC Polymer Science GA GL630 UT WOS:A1991GL63000017 ER PT J AU ADLER, M REUTTER, SA MOORE, DH FILBERT, MG AF ADLER, M REUTTER, SA MOORE, DH FILBERT, MG TI REGULATION OF ACETYLCHOLINE HYDROLYSIS IN CANINE TRACHEAL SMOOTH-MUSCLE SO EUROPEAN JOURNAL OF PHARMACOLOGY LA English DT Article DE TRACHEA (CANINE); SMOOTH MUSCLE; ACETYLCHOLINESTERASE; BUTYRYLCHOLINESTERASE; BW 284C51; TETRAISOPROPYLPYROPHOSPHORAMIDE (ISO-OMPA) ID RAT AB The regulation of acetylcholine (ACh) lifetime by acetylcholinesterase (AChE, EC 3.1.1.7) and butyrylcholinesterase (BuChE, EC 3.1.1.8) was evaluated in vitro in canine tracheal smooth muscle preparations. Selective inhibition of AChE by low concentrations of 1,5-bis(N-allyl-N,N-dimethyl-4-ammoniumphenyl)-pentane-3-one dibromide (BW 284C51) led to increases in the amplitude and half-relaxation time of contractions elicited by electric field stimulation. Maximal responses were observed in the presence of 10(-6) M BW 284C51, where the amplitude and half-relaxation time were increased by 84 and 198%, respectively. Higher concentrations of BW 284C51, on the other hand, depressed the amplitude and shortened the decay of electric field stimulation-induced contractions by a mechanism involving blockade of muscarinic receptors. Selective inhibition of BuChE by tetraisopropylpyrophosphoramide (iso-OMPA) led to monotonic increases in the electric field stimulation amplitude and duration. These alterations were less marked than those observed in the presence of BW 284C51. Co-application of BW 284C51 (10(-5) M) and iso-OMPA (10(-5) M) resulted in a 1330% prolongation in the decay of electric field stimulation-induced contractions and the development of a sustained contracture. Such contractures were not observed with either inhibitor alone at any concentration tested. The results indicate that both hydrolytic enzymes are involved in the regulation of ACh lifetime at the canine tracheal neuroeffector junction with AChE exerting the more prominent role. The finding that BuChE co-regulates ACh lifetime in canine trachealis muscle demonstrates a functional role for this enzyme. RP ADLER, M (reprint author), USA,MED RES INST CHEM DEF,DIV PATHOPHYSIOL,NEUROTOXICOL BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 16 TC 18 Z9 18 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0014-2999 J9 EUR J PHARMACOL JI Eur. J. Pharmacol. PD NOV 19 PY 1991 VL 205 IS 1 BP 73 EP 79 DI 10.1016/0014-2999(91)90772-I PG 7 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA GU077 UT WOS:A1991GU07700012 PM 1812000 ER PT J AU KARLE, JM KARLE, IL AF KARLE, JM KARLE, IL TI STRUCTURE OF THE ANTIMALARIAL (+/-)-MEFLOQUINE HYDROCHLORIDE SO ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS LA English DT Article ID MOLECULAR-STRUCTURE; QUINIDINE; CRYSTAL; RESISTANCE; QUININE; MALARIA AB (11R*,12S*)-(+/-)-alpha-2-Piperidinyl-2,8-bis-(trifluoromethyl)-4-quinolinemethanol monohydrochloride, C17H17F6N2O+.Cl-.0.5CH3OH, M(r) = 430.8, tetragonal, P4(2)/n (origin at center of symmetry), a = b = 24.595 (4), c = 6.398 (2) angstrom, V = 3870.0 angstrom 3, Z = 8, D(x) = 1.48 g cm-3, Cu K-alpha, lambda = 1.54178 angstrom, mu = 24.28 cm-1, F(000) = 1768, room temperature, final R = 7.5% for 2067 reflections with \F(o)\ > 3-sigma(F). Mefloquine hydrochloride crystallized as a secondary amine salt with channels of disordered methanol solvent. The trifluoromethyl group on the C adjacent to the quinoline N atom exhibited rotational disorder. Each chloride ion accepts three hydrogen bonds, one each from the hydroxyl group and the two H atoms of the amine group of mefloquine from three separate molecules. The angle between the average plane of the quinoline ring and the average plane of the piperidine ring is 110.5-degrees. C1 USN,RES LAB,STRUCT MATTER LAB,WASHINGTON,DC 20375. RP KARLE, JM (reprint author), WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,DEPT PHARMACOL,WASHINGTON,DC 20307, USA. NR 19 TC 19 Z9 19 U1 0 U2 5 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0108-2701 J9 ACTA CRYSTALLOGR C JI Acta Crystallogr. Sect. C-Cryst. Struct. Commun. PD NOV 15 PY 1991 VL 47 BP 2391 EP 2395 DI 10.1107/S0108270191005796 PN 11 PG 5 WC Chemistry, Multidisciplinary; Crystallography SC Chemistry; Crystallography GA GR136 UT WOS:A1991GR13600042 ER PT J AU DENNIS, GJ KEATING, RM AF DENNIS, GJ KEATING, RM TI MUSCLE INFARCTION IN SICKLE-CELL-ANEMIA SO ANNALS OF INTERNAL MEDICINE LA English DT Letter RP DENNIS, GJ (reprint author), WALTER REED ARMY MED CTR,RHEUMATOL SERV,WASHINGTON,DC 20307, USA. NR 4 TC 4 Z9 4 U1 0 U2 0 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD NOV 15 PY 1991 VL 115 IS 10 BP 831 EP 832 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA GP800 UT WOS:A1991GP80000020 PM 1781865 ER PT J AU DILLMAN, RO DAVIS, RB GREEN, MR WEISS, RB GOTTLIEB, AJ CAPLAN, S KOPEL, S PREISLER, H MCINTYRE, OR SCHIFFER, C AF DILLMAN, RO DAVIS, RB GREEN, MR WEISS, RB GOTTLIEB, AJ CAPLAN, S KOPEL, S PREISLER, H MCINTYRE, OR SCHIFFER, C TI A COMPARATIVE-STUDY OF 2 DIFFERENT DOSES OF CYTARABINE FOR ACUTE MYELOID-LEUKEMIA - A PHASE-III TRIAL OF CANCER AND LEUKEMIA GROUP-B SO BLOOD LA English DT Article ID ACUTE NONLYMPHOCYTIC LEUKEMIA; ACUTE MYELOGENOUS LEUKEMIA; ACUTE MYELOCYTIC-LEUKEMIA; CYTOSINE-ARABINOSIDE; MAINTENANCE CHEMOTHERAPY; CONTINGENCY-TABLES; THERAPY; CONSOLIDATION; DAUNORUBICIN; REMISSION C1 UNIV CALIF SAN DIEGO,SCH MED,SAN DIEGO,CA 92103. HARVARD UNIV,SCH PUBL HLTH,BOSTON,MA 02115. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. SUNY UPSTATE MED CTR,SYRACUSE,NY 13210. MCGILL UNIV,MONTREAL H3A 2T5,QUEBEC,CANADA. MAIMONIDES HOSP,BROOKLYN,NY 11219. NEW YORK STATE DEPT HLTH,ROSWELL PK MEM INST,BUFFALO,NY 14263. UNIV MARYLAND,CTR CANC,BALTIMORE,MD 21201. DARTMOUTH COLL,HITCHCOCK CANC CTR,HANOVER,NH 03755. FU NCI NIH HHS [CA-21060, CA-26806]; PHS HHS [11789] NR 27 TC 138 Z9 140 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD NOV 15 PY 1991 VL 78 IS 10 BP 2520 EP 2526 PG 7 WC Hematology SC Hematology GA GP887 UT WOS:A1991GP88700006 PM 1824249 ER PT J AU ZAINO, RJ KURMAN, R HERBOLD, D GLIEDMAN, J BUNDY, BN VOET, R ADVANI, H AF ZAINO, RJ KURMAN, R HERBOLD, D GLIEDMAN, J BUNDY, BN VOET, R ADVANI, H TI THE SIGNIFICANCE OF SQUAMOUS DIFFERENTIATION IN ENDOMETRIAL CARCINOMA - DATA FROM A GYNECOLOGIC-ONCOLOGY-GROUP-STUDY SO CANCER LA English DT Article ID MIXED ADENOSQUAMOUS CARCINOMA; FOLLOW-UP; STAGE-I; ADENOACANTHOMA; CANCER; ADENOCARCINOMA; ENTITY; SPREAD; WOMEN AB Squamous differentiation is identified in about 25% of endometrial adenocarcinomas (AC). Its significance has been the subject of debate for decades, and it has been reported that the prognosis of adenoacanthoma (AA) is better than, the same as, and worse than that of AC. Part of this confusion has resulted from semantic differences relating to the use of AA and adenosquamous carcinoma (AS). To investigate the prognostic importance of squamous differentiation in endometrial carcinomas and compare the prognostic utility of two classification systems, 456 women were studied who had typical AC and 175 women who had typical AC containing areas of squamous differentiation (AC + SQ) and who had been entered in a Gynecologic Oncology Group protocol of Stage I and II endometrial adenocarcinoma. Assessment of histologic grade and depth of invasion was done both by the pathologist at the member institution and at a second highly structured review. Differentiation of the squamous component of endometrial carcinomas was found to parallel that of the glandular component in most tumors. The biologic behavior of endometrial carcinomas with squamous elements was similar, but not identical, to that of typical AC. Although the frequency of nodal metastasis was similar for both AC and AC + SQ, the presence of squamous elements was associated with an increased probability of survival. Division of AC + SQ by depth of myometrial invasion and by architectural grade of the glandular component provided useful prognostic information that was superior to that resulting simply from division of AC + SQ into AA or AS. The authors recommend that these terms be replaced by "adenocarcinoma with squamous differentiation" and that the pathologist provide information on the architectural grade and depth of myometrial invasion to guide the gynecologist in determining appropriate therapy. C1 JOHNS HOPKINS UNIV,SCH MED,BALTIMORE,MD 21205. LATTER DAY ST HOSP,SALT LAKE CITY,UT 84143. NEW YORK STATE DEPT HLTH,ROSWELL PK MEM INST,BUFFALO,NY 14263. UNIV TEXAS,SW MED CTR,DALLAS,TX 75230. UNIFORMED SERV UNIV HLTH SCI,WALTER REED ARMY MED CTR,BETHESDA,MD 20814. UNIV KANSAS,SCH MED,WICHITA,KS. RP ZAINO, RJ (reprint author), PENN STATE UNIV,MILTON S HERSHEY MED CTR,DEPT PATHOL,HERSHEY,PA 17033, USA. FU NCI NIH HHS [CA 12484, CA 12534, CA 27816] NR 32 TC 84 Z9 86 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD NOV 15 PY 1991 VL 68 IS 10 BP 2293 EP 2302 DI 10.1002/1097-0142(19911115)68:10<2293::AID-CNCR2820681032>3.0.CO;2-V PG 10 WC Oncology SC Oncology GA GL938 UT WOS:A1991GL93800031 PM 1913465 ER PT J AU LEUPOLD, HA POTENZIANI, E AF LEUPOLD, HA POTENZIANI, E TI AUGMENTATION OF FIELD UNIFORMITY AND STRENGTH IN SPHERICAL AND CYLINDRICAL MAGNETIC-FIELD SOURCES SO JOURNAL OF APPLIED PHYSICS LA English DT Article; Proceedings Paper CT 5TH JOINT MAGNETISM AND MAGNETIC MATERIALS - INTERM CONF CY JUN 18-21, 1991 CL PITTSBURGH, PA SP AMER INST PHYS, IEEE, MAGNET SOC AB High magnetic fields (almost-equal-to 20 kG) are realizable from spherical and cylindrical transverse field sources in relatively small structures (approximately 10 cm). In some applications where the working space is cylindrical and long compared to its diameter, these fields can be augmented by about 5 kOe without an increase in the outer dimensions of the original structures. In spherical sources, a similar procedure yields a field increase of approximately 3 kOe. A method is described whereby field distortions arising from access holes to the interiors of such magnet structures can be greatly reduced. Such options considerably enhance the range of applicability to millimeter/microwave and optical devices. RP LEUPOLD, HA (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. NR 5 TC 17 Z9 17 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD NOV 15 PY 1991 VL 70 IS 10 BP 6621 EP 6623 DI 10.1063/1.349877 PN 2 PG 3 WC Physics, Applied SC Physics GA GQ945 UT WOS:A1991GQ94500308 ER PT J AU LEUPOLD, HA KOSA, L MCLANE, G TILAK, AS POTENZIANI, E AF LEUPOLD, HA KOSA, L MCLANE, G TILAK, AS POTENZIANI, E TI PERMANENT-MAGNET SOURCES FOR EXTENDED INTERACTION KLYSTRONS SO JOURNAL OF APPLIED PHYSICS LA English DT Article; Proceedings Paper CT 5TH JOINT MAGNETISM AND MAGNETIC MATERIALS - INTERM CONF CY JUN 18-21, 1991 CL PITTSBURGH, PA SP AMER INST PHYS, IEEE, MAGNET SOC ID FIELDS AB A major part of the bulk and mass of an extended interaction amplifier resides in its magnetic field source. Both can be considerably reduced by application of novel designs made possible by high-energy product permanent magnet materials such as the samarium-cobalts and neodymium-iron-borides. We compare a structure derived from a hemispherical source design ("magic igloo") with several more conventional permanent magnet and electromagnet configurations and find that mass reductions of 50% to 80% are often realized when the hemispherical source replaces any of the others. Such reductions afford considerable performance improvement in radars, radios, and jammers, especially in airborne and ballistic devices. Further compaction results from closer packing of field-sensitive instruments afforded by leakage field reduction in the hemispherical source. Other advantages of the latter as well as drawbacks, are discussed. RP LEUPOLD, HA (reprint author), USA,TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. NR 9 TC 1 Z9 1 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD NOV 15 PY 1991 VL 70 IS 10 BP 6624 EP 6626 DI 10.1063/1.349878 PN 2 PG 3 WC Physics, Applied SC Physics GA GQ945 UT WOS:A1991GQ94500309 ER PT J AU LI, Y KRIEGER, JB NORMAN, MR IAFRATE, GJ AF LI, Y KRIEGER, JB NORMAN, MR IAFRATE, GJ TI BAND-STRUCTURE CALCULATIONS OF NOBLE-GAS AND ALKALI-HALIDE SOLIDS USING ACCURATE KOHN-SHAM POTENTIALS WITH SELF-INTERACTION CORRECTION SO PHYSICAL REVIEW B LA English DT Article ID DENSITY-FUNCTIONAL THEORY; DERIVATIVE DISCONTINUITIES; ELECTRONIC-STRUCTURE; ENERGY-BANDS; PHOTOEMISSION; EXCHANGE; LICL; NACL AB The optimized-effective-potential (OEP) method and a method developed recently by Krieger, Li, and Iafrate (KLI) are applied to the band-structure calculations of noble-gas and alkali halide solids employing the self-interaction-corrected (SIC) local-spin-density (LSD) approximation for the exchange-correlation energy functional. The resulting band gaps from both calculations are found to be in fair agreement with the experimental values. The discrepancies are typically within a few percent with results that are nearly the same as those of previously published orbital-dependent multipotential SIC calculations, whereas the LSD results underestimate the band gaps by as much as 40%. As in the LSD- and it is believed to be the case even for the exact Kohn-Sham potential-both the OEP and KLI predict valence-band widths which are narrower than those of experiment. In all cases, the KLI method yields essentially the same results as the OEP. C1 ARGONNE NATL LAB, DIV MAT SCI, ARGONNE, IL 60439 USA. USA, RES OFF, RES TRIANGLE PK, NC 27709 USA. RP CUNY BROOKLYN COLL, DEPT PHYS, BROOKLYN, NY 11210 USA. RI Norman, Michael/C-3644-2013 NR 37 TC 52 Z9 52 U1 0 U2 3 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9950 EI 2469-9969 J9 PHYS REV B JI Phys. Rev. B PD NOV 15 PY 1991 VL 44 IS 19 BP 10437 EP 10443 DI 10.1103/PhysRevB.44.10437 PG 7 WC Physics, Condensed Matter SC Physics GA GP689 UT WOS:A1991GP68900001 ER PT J AU LEAVITT, RP BRADSHAW, JL TOWNER, FJ AF LEAVITT, RP BRADSHAW, JL TOWNER, FJ TI STARK LOCALIZATION IN SUPERLATTICES - COMPARISON OF AN EMPIRICAL 2-BAND MODEL WITH EXPERIMENT SO PHYSICAL REVIEW B LA English DT Article ID SEMICONDUCTOR QUANTUM WELLS; ELECTRIC-FIELD; NONPARABOLICITY; PARAMETERS AB We have measured the electron-hole transition energies in a strongly coupled GaAs/Al0.3Ga0.7As superlattice in an electric field. The results of these measurements are compared with calculations based on an empirical two-band model, including excitonic effects. Excellent agreement is obtained between theory and experiment with no adjustments to the parameters in the calculations. This comparison provides a stringent test of the theory and shows that simple envelope-function formalisms are capable of accurate predictions of the optical properties of superlattices with thin (approximately 20 angstrom) layers. C1 MARTIN MARIETTA CORP,BALTIMORE,MD 21227. RP LEAVITT, RP (reprint author), USA,COMMAND LAB,HARRY DIAMOND LABS,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. RI Bradshaw, John/E-8330-2011 NR 20 TC 4 Z9 4 U1 0 U2 0 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD NOV 15 PY 1991 VL 44 IS 20 BP 11266 EP 11269 DI 10.1103/PhysRevB.44.11266 PG 4 WC Physics, Condensed Matter SC Physics GA GR559 UT WOS:A1991GR55900030 ER PT J AU LEAVITT, RP AF LEAVITT, RP TI EMPIRICAL 2-BAND MODEL FOR QUANTUM-WELLS AND SUPERLATTICES IN AN ELECTRIC-FIELD SO PHYSICAL REVIEW B LA English DT Article ID ENVELOPE-FUNCTION APPROXIMATION; LATTICE BAND-STRUCTURE; SEMICONDUCTOR HETEROSTRUCTURES; NONPARABOLICITY; RESONANCE; STATES; TRANSITIONS; ABSORPTION; SHIFT; MASS AB This paper considers in detail the empirical two-band model formulated by Nelson et al. [Phys. Rev. B 35, 7770 (1987)] for the electronic states of semiconductor quantum wells and superlattices. The model is also extended to the case where the structure of interest is in an external potential. It is shown that one can define probability and probability current densities such that a continuity equation is satisfied and that solutions corresponding to different energies are orthogonal. Expressions are derived for the oscillator strengths of interband transitions and of intersubband transitions within the conduction band. The pair of coupled first-order differential equations resulting from the model can be recast into a single, second-order Schrodinger equation with an energy- and position-dependent effective mass. For a uniform electric field, it is shown that analytic solutions to this equation can be obtained with an error of order (gamma-F)2, where gamma is the nonparabolicity parameter and F is the electric field. For a 200-angstrom rectangular GaAs/AlxGa1-xAs quantum well, results are presented for electric-field-dependent conduction-subband energies, envelope functions, interband oscillator strengths, and tunneling resonance widths. These results are compared with the corresponding results obtained by a direct numerical integration of the two-band-model Schrodinger equation and with results obtained using the single-band envelope-function approximation. RP LEAVITT, RP (reprint author), USA,COMMAND LAB,HARRY DIAMOND LABS,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. NR 30 TC 37 Z9 37 U1 0 U2 2 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD NOV 15 PY 1991 VL 44 IS 20 BP 11270 EP 11280 DI 10.1103/PhysRevB.44.11270 PG 11 WC Physics, Condensed Matter SC Physics GA GR559 UT WOS:A1991GR55900031 ER PT J AU THOMSEN, JR EDMONDS, C AF THOMSEN, JR EDMONDS, C TI CROUP - A COMMON CAUSE OF AIRWAY-OBSTRUCTION IN CHILDREN SO POSTGRADUATE MEDICINE LA English DT Article ID LARYNGOTRACHEITIS; MANAGEMENT AB Although viral croup is usually a self-limiting disease, its signs and symptoms are distressing enough to make parents seek immediate medical advice. This is fortunate because a much more serious disorder may be present. Indeed, morbidity requiring hospitalization may occur, as may a true emergency. Drs Thomsen and Edmonds discuss the epidemiology and current management of croup and related conditions. C1 GEORGE WASHINGTON UNIV,DEPT SURG,WASHINGTON,DC 20052. GEORGE WASHINGTON UNIV,DEPT PEDIAT,WASHINGTON,DC 20052. WALTER REED ARMY MED CTR,DEPT OTOLARYNGOL,WASHINGTON,DC 20307. RP THOMSEN, JR (reprint author), PEDIAT EAR NOSE & THROAT ATLANTA,PC 5455 MERIDIAN MARK RD,SUITE 130,ATLANTA,GA 30342, USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU MCGRAW HILL HEALTHCARE PUBLICATIONS PI MINNEAPOLIS PA 4530 WEST 77TH ST, MINNEAPOLIS, MN 55435-5000 SN 0032-5481 J9 POSTGRAD MED JI Postgrad. Med. PD NOV 15 PY 1991 VL 90 IS 7 BP 97 EP & PG 0 WC Medicine, General & Internal SC General & Internal Medicine GA GR244 UT WOS:A1991GR24400014 PM 1946123 ER PT J AU JAYASURIYA, K AF JAYASURIYA, K TI A COMPUTATIONAL ANALYSIS OF ELECTRONIC EFFECTS OF BORAZINE AND ITS MONOSUBSTITUTED DERIVATIVES SO THEOCHEM-JOURNAL OF MOLECULAR STRUCTURE LA English DT Article AB The effect of several subtituent groups on the borazine ring has been investigated by an ab initio molecular orbital (SCF) method at the 6-31 G level. The optimized geometry was used to calculate the molecular electrostatic potential of these structures at the 6-31 G level. The negative potentials generated near the B-H protons suggest that these protons are more easily substituted than the N-H protons in borazine. The magnitude of the negative potential near the B-H protons decreases in the order OH > F > NO2, reflecting their varying electron-withdrawing ability. Both the methyl and amino groups tend to increase this negative potential indicating their electron-donating ability. RP JAYASURIYA, K (reprint author), USA,CTR RES DEV & ENGN,GEO CTR CORP,BLDG 3028,PICATINNY ARSENAL,NJ 07806, USA. NR 17 TC 2 Z9 2 U1 1 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-1280 J9 THEOCHEM-J MOL STRUC JI Theochem-J. Mol. Struct. PD NOV 15 PY 1991 VL 82 IS 3-4 BP 381 EP 391 PG 11 WC Chemistry, Physical SC Chemistry GA GT778 UT WOS:A1991GT77800016 ER PT J AU HYAMS, KC BOURGEOIS, AL MERRELL, BR ROZMAJZL, P ESCAMILLA, J THORNTON, SA WASSERMAN, GM BURKE, A ECHEVERRIA, P GREEN, KY KAPIKIAN, AZ WOODY, JN AF HYAMS, KC BOURGEOIS, AL MERRELL, BR ROZMAJZL, P ESCAMILLA, J THORNTON, SA WASSERMAN, GM BURKE, A ECHEVERRIA, P GREEN, KY KAPIKIAN, AZ WOODY, JN TI DIARRHEAL DISEASE DURING OPERATION-DESERT-SHIELD SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID TOXIGENIC ESCHERICHIA-COLI; TRAVELERS DIARRHEA; NORWALK VIRUS; SOUTH-KOREA; TRIMETHOPRIM; SHIGELLA; ANTIGEN; SULFAMETHOXAZOLE; GASTROENTERITIS; CHILDREN AB Background. Under combat conditions infectious disease can become a major threat to military forces. During Operation Desert Shield, there were numerous outbreaks of diarrhea among the U.S. forces. To evaluate the causes of and risk factors for diarrheal disease, we collected clinical and epidemiologic data from U.S. troops stationed in northeastern Saudi Arabia. Methods. Between September and December 1990, stool cultures for enteric pathogens were obtained from 432 military personnel who presented with diarrhea, cramps, vomiting, or hematochezia. In addition, a questionnaire was administered to 2022 soldiers in U.S. military units located in various regions of Saudi Arabia. Results. A bacterial enteric pathogen was identified in 49.5 percent of the troops with gastroenteritis. Enterotoxigenic Escherichia coli and Shigella sonnei were the most common bacterial pathogens. Of 125 E. coli infections, 39 percent were resistant to trimethoprim-sulfamethoxazole, 63 percent to tetracycline, and 48 percent to ampicillin. Of 113 shigella infections, 85 percent were resistant to trimethoprim-sulfamethoxazole, 68 percent to tetracycline, and 21 percent to ampicillin. All bacterial isolates were sensitive to norfloxacin and ciprofloxacin. After an average of two months in Saudi Arabia, 57 percent of the surveyed troops had at least one episode of diarrhea, and 20 percent reported that they were temporarily unable to carry out their duties because of diarrheal symptoms. Vomiting was infrequently reported as a primary symptom, but of 11 military personnel in whom vomiting was a major symptom, 9 (82 percent) had serologic evidence of infection with the Norwalk virus. Conclusions. Gastroenteritis caused by enterotoxigenic E coli and shigella resistant to a number of drugs was a major problem that frequently interfered with the duties of U.S. troops during Operation Desert Shield. C1 ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. NIH,INFECT DIS LAB,BETHESDA,MD 20892. USN,MED RES & DEV COMMAND,BETHESDA,MD 20814. USN,MED RES INST DETACHMENT,LIMA,PERU. USN,ENVIRONM & PREVENT MED UNIT 7,NAPLES,ITALY. USA,MED DEPT ACT,PREVENT MED SERV,FT CAMPBELL,KY. USN,MED RES UNIT 3,DIV EPIDEMIOL,CAIRO,EGYPT. WILLIAM BEAUMONT ARMY MED CTR,DEPT PEDIAT,EL PASO,TX 79920. RP HYAMS, KC (reprint author), USN,MED RES INST,DIV EPIDEMIOL,12300 WASHINGTON AVE,ROCKVILLE,MD 20852, USA. NR 47 TC 193 Z9 201 U1 0 U2 1 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD NOV 14 PY 1991 VL 325 IS 20 BP 1423 EP 1428 DI 10.1056/NEJM199111143252006 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA GP524 UT WOS:A1991GP52400006 PM 1656260 ER PT J AU RUSTAD, JR YUEN, DA SPERA, FJ AF RUSTAD, JR YUEN, DA SPERA, FJ TI THE STATISTICAL GEOMETRY OF AMORPHOUS SILICA AT LOWER MANTLE PRESSURES - IMPLICATIONS FOR MELTING SLOPES OF SILICATES AND ANHARMONICITY SO JOURNAL OF GEOPHYSICAL RESEARCH-SOLID EARTH LA English DT Article ID INDUCED COORDINATION CHANGES; MOLECULAR-DYNAMICS; SIO2; LIQUID; GLASS; COMPRESSION; SIMULATION; MODELS AB Coordination changes occurring in amorphous silica have been studied by analysis of Voronoi and Delaunay tessellations of structures generated by molecular dynamics simulations up to pressures characteristic of the core-mantle boundary. These calculations predict the coexistence of a remarkable variety of silicon coordination environments at pressures above the mantle transition zone. The postoctahedral compression paths identified through the Voronoi and Delaunay constructions and the increase in geometrical entropy that would be expected to be associated with the loss of short-range order may explain the persistence of the low melting slopes determined for many silicates at pressures from 30 to 60 GPa. The simulated glass transforms from fourfold to sixfold coordination asymmetrically, with a significant number passing through a five-coordinated state. Paths of structural change producing sevenfold- and eightfold- coordinated silicon atoms do not necessarily involve coordination changes in unit increments; for example, sixfold coordination states tend to change to eightfold coordination states without passing through the sevenfold state. The large assortment of coordination types precludes a simple, comprehensive model for compression in amorphous silica at high pressures. Anharmonic properties, such as thermal expansivity, do not appear to be affected by changes in geometrical (Voronoi) coordination in the same way that they are dependent on physical coordination defined in terms of average bond lengths. C1 UNIV CALIF SANTA BARBARA,INST CRUSTAL STUDIES,SANTA BARBARA,CA 93106. UNIV CALIF SANTA BARBARA,DEPT GEOL SCI,SANTA BARBARA,CA 93106. UNIV MINNESOTA,DEPT GEOL & GEOPHYS,MINNEAPOLIS,MN 55415. RP RUSTAD, JR (reprint author), MINNESOTA SUPERCOMP INST,ARMY HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55415, USA. NR 36 TC 15 Z9 15 U1 1 U2 5 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0148-0227 J9 J GEOPHYS RES-SOL EA JI J. Geophys. Res.-Solid Earth PD NOV 10 PY 1991 VL 96 IS B12 BP 19665 EP 19673 DI 10.1029/91JB01925 PG 9 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA GQ691 UT WOS:A1991GQ69100010 ER PT J AU WADE, WL MAMMONE, RJ BINDER, M AF WADE, WL MAMMONE, RJ BINDER, M TI SURFACE-PROPERTIES OF COMMERCIAL POLYMER-FILMS FOLLOWING VARIOUS GAS PLASMA TREATMENTS SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article AB Surface properties of a number of commercial thermoplastic Polymer films were investigated before and after brief exposures to RF induced, low temperature gas plasmas. Water wettability and adhesion of vapor deposited aluminum to thin films (8-12 micron) of polyethylene, polypropylene, polyester, Polysulfone, polycarbonate, and polyvinylidene fluoride films were studied before and after treatments with oxygen, 96% CF4/4% O2, and helium plasmas. Treatment with oxygen plasmas showed the greatest change in water wettability for polyvinylidene fluoride and polypropylene films, while treatment with 96% CF4/4% O2 showed dramatic changes in wettability of polycarbonate, polysulfone, and polystyrene. Excellent adhesion of aluminum was found for polymers that had been previously exposed to gas plasmas. RP WADE, WL (reprint author), USA,ELECTR TECHNOL & DEVICES LAB LABCOM,DIV POWER SOURCES,SLCET PR,FT MONMOUTH,NJ 07703, USA. NR 3 TC 56 Z9 56 U1 1 U2 7 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0021-8995 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD NOV 5 PY 1991 VL 43 IS 9 BP 1589 EP 1591 DI 10.1002/app.1991.070430901 PG 3 WC Polymer Science SC Polymer Science GA GL520 UT WOS:A1991GL52000001 ER PT J AU LEAVITT, RP BRADSHAW, JL AF LEAVITT, RP BRADSHAW, JL TI TRANSIT-TIME EFFECTS ON PHOTOCURRENT SPECTRA OF MULTIPLE QUANTUM-WELL DIODES SO APPLIED PHYSICS LETTERS LA English DT Article ID ELECTRIC-FIELD; ABSORPTION AB We consider the effects on photocurrent spectra of the finite transit times of carriers through the 2-mu-m-thick intrinsic region of a p-i-n diode containing multiple quantum wells. If the transit time is comparable to or greater than the carrier recombination time, the photocurrent spectra show severe distortion. We have observed an anomalously large decrease in the diode's quantum efficiency, accompanied by a compression of the spectral features and eventually an apparent splitting of each photocurrent peak into two separate peaks, as the electric field is lowered. A carrier-transport model is presented that accurately describes the essential experimental features. RP LEAVITT, RP (reprint author), USA,LAB COMMAND,HARRY DIAMOND LABS,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. RI Bradshaw, John/E-8330-2011 NR 12 TC 18 Z9 18 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD NOV 4 PY 1991 VL 59 IS 19 BP 2433 EP 2435 DI 10.1063/1.106012 PG 3 WC Physics, Applied SC Physics GA GM782 UT WOS:A1991GM78200029 ER PT J AU MATHER, B AF MATHER, B TI FLY-ASH IN HIGH-STRENGTH CONCRETE SO ACI MATERIALS JOURNAL LA English DT Discussion RP MATHER, B (reprint author), USA,DEPT ARMY,ENGINEER WATERWAYS EXPT STN,VICKSBURG,MS 39180, USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CONCRETE INST PI FARMINGTON HILLS PA 38800 INTERNATIONAL WAY, COUNTRY CLUB DRIVE, PO BOX 9094, FARMINGTON HILLS, MI 48333-9094 SN 0889-325X J9 ACI MATER J JI ACI Mater. J. PD NOV-DEC PY 1991 VL 88 IS 6 BP 675 EP 675 PG 1 WC Construction & Building Technology; Materials Science, Multidisciplinary SC Construction & Building Technology; Materials Science GA GU670 UT WOS:A1991GU67000014 ER PT J AU MCCAUL, TF WILLIAMS, JC THOMPSON, HA AF MCCAUL, TF WILLIAMS, JC THOMPSON, HA TI ELECTRON-MICROSCOPY OF COXIELLA-BURNETII IN TISSUE-CULTURE - INDUCTION OF CELL-TYPES AS PRODUCTS OF DEVELOPMENTAL CYCLE SO ACTA VIROLOGICA LA English DT Article DE COXIELLA-BURNETII; TISSUE CULTURE; DEVELOPMENTAL CYCLE; SPOROGENESIS; ELECTRON MICROSCOPY ID PHASE-I; Q-FEVER AB An in vitro ultrastructural study was carried out on tissue cultures (J774, murine macrophage-like tumour cell line, and BHK-21, baby hamster kidney cell line) persistently infected with C. burnetti to investigate whether the events of cellular differentiation could be visualized. At a given stage of the developmental cycle, a proportion of the cells within the affected phagolysosomes clearly underwent cellular differentiation. The cells initially showed asymmetrical septation, the primary stage of cellular differentiation, and ended with the formation of the differentiated product, a precursor to the small cell. The results verified our initial observation that the events occurring during growth in a phagolysosome represent stages of a complex developmental cycle consisting not only of i) vegetative growth by typical transverse binary fission, but also ii) cellular differentiation. C1 USA,MED INST INFECT DIS,DEPT INTRACELLULAR PATHOGENS,FT DETRICK,FREDERICK,MD 21702. NIAID,OFF DIRECTOR INTRAMURAL RES PROGRAMS,BETHESDA,MD 20892. W VIRGINIA UNIV,MED CTR,SCH MED,DEPT MICROBIOL & IMMUNOL,MORGANTOWN,WV 26506. RP MCCAUL, TF (reprint author), UNIV QUEENSLAND,CTR ELECTRON MICROSCOPE,ST LUCIA,QLD 4072,AUSTRALIA. NR 21 TC 10 Z9 10 U1 0 U2 1 PU SLOVAK ACADEMIC PRESS LTD PI BRATISLAVA PA PO BOX 57, NAM SLOBODY 6, 810 05 BRATISLAVA, SLOVAKIA SN 0001-723X J9 ACTA VIROL JI Acta Virol. PD NOV PY 1991 VL 35 IS 6 BP 545 EP 556 PG 12 WC Virology SC Virology GA HB173 UT WOS:A1991HB17300008 PM 1687638 ER PT J AU BOLAN, CD ALVING, BM AF BOLAN, CD ALVING, BM TI RECURRENT VENOUS THROMBOSIS AND HYPERCOAGULABLE STATES SO AMERICAN FAMILY PHYSICIAN LA English DT Article AB Patients with recurrent venous thrombosis, or those with thrombosis at a young age (less than 45 years) and a family history of thrombotic disorders, may have an inherited hypercoagulable disorder. The most common disorders are deficiencies of protein S, protein C and antithrombin III, inhibitors of the coagulation cascade. These deficiencies may be found in approximately 10 percent of patients who are under age 45 and have venous thrombosis. Acquired disorders associated with recurrent venous thrombosis include carcinoma and antiphospholipid antibody syndrome. Appropriate anticoagulation can reduce the risk of recurrent thrombosis in patients with inherited and acquired abnormalities. RP BOLAN, CD (reprint author), USA,WOMACK ARMY COMMUNITY HOSP,FT BRAGG,NC 28307, USA. NR 0 TC 5 Z9 5 U1 1 U2 1 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD NOV PY 1991 VL 44 IS 5 BP 1741 EP 1751 PG 11 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA GQ618 UT WOS:A1991GQ61800022 PM 1835274 ER PT J AU KHURANA, RK PETRAS, JM AF KHURANA, RK PETRAS, JM TI SENSORY INNERVATION OF THE CANINE ESOPHAGUS, STOMACH, AND DUODENUM SO AMERICAN JOURNAL OF ANATOMY LA English DT Article ID GUINEA-PIG PYLORUS; HORSERADISH-PEROXIDASE; AFFERENT INNERVATION; SPINAL-CORD; NEURONS; CAT; VAGAL; TRANSPORT; FIBERS; HRP AB The sensory innervation of the Postpharyngeal foregut was investigated by injecting the enzyme horseradish peroxidase (HRP) into the walls of the esophagus, stomach, or duodenum. The transported HRP was identified histochemically, labeled neurons in the spinal and vagal ganglia were counted, and the results were plotted using an SAS statistical program. The spinal sensory fields of each viscus were defined using three determinations: craniocaudal extent, principal innervation field, and peak innervation field. The data revealed that innervation fields are craniocaudally extensive, the sensory field of each viscus overlaps significantly with its neighbor, yet each viscus can be characterized by a field of peak innervation density. Craniocaudal innervation of the esophagus spans as many as 22-23 paired spinal ganglia (C1-L2). There are two peak innervation fields for the cervical (C2-C6, and T2-T4) and for the thoracic (T2-T4 and T8-T12) sectors of the esophagus. The sensory innervation of the stomach extends craniocaudally over as many as 25 paired spinal ganglia (C2-L5). The peak innervation field of the stomach spans a large area comprising the cranial, middle, and the immediately adjoining caudal thoracic ganglia (T2-T10). The duodenum is innervated craniocaudally by as many as 15 paired thoracolumbar ganglia (T2-L3). Peak innervation originates in the middle and caudal thoracic ganglia and cranial lumbar (T6-L1) ganglia. There is a recognizable viscerotopic organization in the sensory innervation of the postpharyngeal foregut; successively more caudal sectors of this region of the alimentary canal are supplied with sensory fibers from successively more caudal spinal dorsal root ganglia. Vagal afferent innervation of the esophagus, stomach, and duodenum is bilateral and originates predominantly, but not exclusively, from vast numbers of neurons in the nodose (distal) ganglia. The esophagus is innervated bilaterally and more abundantly by jugular (proximal) ganglia neurons than is either the stomach or duodenum. The physiological significance of the findings are discussed in relation to the phenomena of visceral pain and referred pain. C1 WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307. UNIV MARYLAND,SCH MED,DEPT NEUROL,BALTIMORE,MD 21201. NR 58 TC 31 Z9 31 U1 0 U2 2 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0002-9106 J9 AM J ANAT PD NOV PY 1991 VL 192 IS 3 BP 293 EP 306 DI 10.1002/aja.1001920309 PG 14 WC Anatomy & Morphology SC Anatomy & Morphology GA GM674 UT WOS:A1991GM67400008 PM 1759692 ER PT J AU BASS, JW AF BASS, JW TI STAPHYLOCOCCUS-AUREUS IN IMPETIGO - REPLY SO AMERICAN JOURNAL OF DISEASES OF CHILDREN LA English DT Letter RP BASS, JW (reprint author), TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859, USA. NR 1 TC 1 Z9 1 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0002-922X J9 AM J DIS CHILD JI Am. J. Dis. Child. PD NOV PY 1991 VL 145 IS 11 BP 1223 EP 1223 PG 1 WC Pediatrics SC Pediatrics GA GN260 UT WOS:A1991GN26000003 ER PT J AU ABBOTT, KC VUKELJA, SJ SMITH, CE MCALLISTER, CK KONKOL, KA OROURKE, TJ HOLLAND, CJ RISTIC, M AF ABBOTT, KC VUKELJA, SJ SMITH, CE MCALLISTER, CK KONKOL, KA OROURKE, TJ HOLLAND, CJ RISTIC, M TI HEMOPHAGOCYTIC SYNDROME - A CAUSE OF PANCYTOPENIA IN HUMAN EHRLICHIOSIS SO AMERICAN JOURNAL OF HEMATOLOGY LA English DT Article DE PANCYTOPENIA; HEMOPHAGOCYTIC SYNDROME; SHOCK; RICKETTSIA; EHRLICHIA ID BONE-MARROW HYPOPLASIA; MALIGNANT HISTIOCYTOSIS; HUMAN INFECTION; CANIS; LYMPHOMA AB A 67-year-old white man with human ehrlichiosis infection complicated by pancytopenia, hemophagocytic syndrome, disseminated intravascular coagulopathy and septic shock is presented. The patient had been on a three-week camping trip to California, Colorado, Utah, and New Mexico. The diagnosis of human ehrlichiosis was confirmed by sixteenfold rise in antibody titer to Ehrlichia canis, and supported by the characteristic cytoplasmic inclusions. Human ehrlichiosis should be considered in the differential diagnosis in patients with fever and cytopenia associated with hemophagocytosis. Pancytopenia associated with ehrlichiosis is transient; however, it may be severe, and appears to be associated with destruction of normal blood elements. C1 BROOKE ARMY MED CTR,DEPT MED,HEMATOL ONCOL SERV,BEACH PAVILION,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,DEPT MED,INFECT DIS SERV,FT SAM HOUSTON,TX 78234. UNIV ILLINOIS,COLL VET MED,DEPT VET PATHOBIOL,CHAMPAIGN,IL 61820. OI Abbott, Kevin/0000-0003-2111-7112 NR 16 TC 31 Z9 33 U1 0 U2 2 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0361-8609 J9 AM J HEMATOL JI Am. J. Hematol. PD NOV PY 1991 VL 38 IS 3 BP 230 EP 234 DI 10.1002/ajh.2830380315 PG 5 WC Hematology SC Hematology GA GL863 UT WOS:A1991GL86300014 PM 1951324 ER PT J AU TROCHE, V OCONNOR, DM SCHAUDIES, RP AF TROCHE, V OCONNOR, DM SCHAUDIES, RP TI MEASUREMENT OF HUMAN EPIDERMAL GROWTH-FACTOR RECEPTOR IN THE ENDOMETRIUM DURING THE MENSTRUAL-CYCLE SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article DE EPIDERMAL GROWTH FACTOR RECEPTOR; ENDOMETRIUM; MENSTRUAL CYCLE ID BINDING; ESTROGEN; INVITRO; EXPRESSION; TUMORS; CANCER; UTERUS; CELLS AB To evaluate a potential physiologic role of the epidermal growth factor receptor in the endometrium, we measured the receptor content at different times in the menstrual cycle. Endometrial biopsy specimens were obtained from 28 normal women during the proliferative or secretory phase of the menstrual cycle, and the epidermal growth factor receptor content was determined. When the number of epidermal growth factor binding sites were evaluated as a function of time within each phase, a difference between phases became evident. The level of receptor increased during the proliferative phase with a maximum just before ovulation (p = 0.0128, r = 0.748). The epidermal growth factor receptor level decreased during the secretory phase, reaching a minimum before menses (p = 0.0001, r = 0.843). We conclude that the endometrial epidermal growth factor receptor content is cycle dependent, being maximal during the periovulatory period and minimal just before or during menses. These findings further suggest a physiologic role for epidermal growth factor in the proliferation and differentiation of the endometrium. C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP TROCHE, V (reprint author), WALTER REED ARMY MED CTR,DEPT OBSTET & GYNECOL,WASHINGTON,DC 20307, USA. NR 23 TC 29 Z9 29 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD NOV PY 1991 VL 165 IS 5 BP 1499 EP 1503 PN 1 PG 5 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA GQ919 UT WOS:A1991GQ91900052 PM 1957887 ER PT J AU DROMA, T MCCULLOUGH, RG MCCULLOUGH, RE ZHUANG, JG CYMERMAN, A SUN, S SUTTON, JR MOORE, LG AF DROMA, T MCCULLOUGH, RG MCCULLOUGH, RE ZHUANG, JG CYMERMAN, A SUN, S SUTTON, JR MOORE, LG TI INCREASED VITAL AND TOTAL LUNG CAPACITIES IN TIBETAN COMPARED TO HAN RESIDENTS OF LHASA (3,658 M) SO AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY LA English DT Article DE VITAL CAPACITY; RESIDUAL VOLUME; CHEST DIMENSIONS; HYPOXIA; GROWTH AND DEVELOPMENT ID HIGH-ALTITUDE; HYPOXIC ENVIRONMENT; DIFFUSING CAPACITY; HEALTH PROGRAM; GROWTH; POPULATIONS; AYMARA AB Larger chest dimensions and lung volumes have been reported for Andean high-altitude natives compared with sea-level residents and implicated in raising lung diffusing capacity. Studies conducted in Nepal suggested that lifelong Himalayan residents did not have enlarged chest dimensions. To determine if high-altitude Himalayans (Tibetans) had larger lung volumes than acclimatized newcomers (Han "Chinese"), we studied 38 Tibetan and 43 Han residents of Lhasa, Tibet Autonomous Region, China (elevation 3,658 m) matched for age, height, weight, and smoking history. The Tibetan compared with the Han subjects had a larger total lung capacity [6.80 +/- 0.19 (mean +/- SEM) vs 6.24 +/- 0.18 1 BTPS, P < 0.05], vital capacity (5.00 +/- 0.08 vs 4.51 +/- 0.10 1 BTPS, P < 0.05), and tended to have a greater residual volume (1.86 +/- 0.12 vs 1.56 +/- 0.09 1 BTPS, P < 0.06). Chest circumference was greater in the Tibetan than the Han subjects (85 +/- 1 vs 82 +/- 1 cm, P < 0.05) and correlated with vital capacity in each group as well as in the two groups combined (r = 0.69, P < 0. 05). Han who had migrated to high altitude as children (less-than-or-equal-to 5 years old, n = 6) compared to Han adult migrants (greater-than-or-equal-to 18 years old, n = 26) were shorter but had similar lung volumes and capacities when normalized for body size. The Tibetans' vital capacity and total lung capacity in relation to body size were similar to values reported previously for lifelong residents of high altitude in South and North America. Thus, Tibetans, like North and South American high-altitude residents, have larger lung volumes. This may be important for raising lung diffusing capacity and preserving arterial oxygen saturation during exercise. C1 UNIV COLORADO,HLTH SCI CTR,CARDIOVASC PULM RES LAB,DENVER,CO 80262. USA,RIEM,DIV ALTITUDE PHYSIOL & MED,NATICK,MA 01760. UNIV SYDNEY,CUMBERLAND COLL HLTH SCI,LIDCOMBE,NSW 2141,AUSTRALIA. UNIV COLORADO,DEPT ANTHROPOL,DENVER,CO 80217. RP DROMA, T (reprint author), TIBET INST MED SCI,LHASA,PEOPLES R CHINA. FU NHLBI NIH HHS [HLBI 14895]; NICHD NIH HHS [CHD 00681] NR 35 TC 55 Z9 56 U1 1 U2 12 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0002-9483 J9 AM J PHYS ANTHROPOL JI Am. J. Phys. Anthropol. PD NOV PY 1991 VL 86 IS 3 BP 341 EP 351 DI 10.1002/ajpa.1330860303 PG 11 WC Anthropology; Evolutionary Biology SC Anthropology; Evolutionary Biology GA GL005 UT WOS:A1991GL00500002 PM 1746642 ER PT J AU ATKINS, JL LANKFORD, SP AF ATKINS, JL LANKFORD, SP TI CHANGES IN CYTOCHROME OXIDATION IN OUTER AND INNER STRIPES OF OUTER MEDULLA SO AMERICAN JOURNAL OF PHYSIOLOGY LA English DT Article DE OXYGEN TENSION; SARALASIN; FUROSEMIDE; CAPTOPRIL; MEDULLARY BLOOD FLOW ID ACUTE RENAL-FAILURE; RAT-KIDNEY; BLOOD-FLOW; DOG AB To examine regional cytochrome oxidation in the outer medulla, we developed fiber optic probes that allowed us to obtain localized reflectance measurements from the outer and inner stripes of the outer medulla. We measured directional changes in cytochrome oxidation in these two regions. In the outer stripe furosemide surprisingly caused a significant decrease in cytochrome oxidation. The decrease occurred concomitantly with a fall in outer medullary blood flow as measured by laser-Doppler flowmetry. Saralasin, an antagonist of angiotensin II caused a significant increase in cytochrome oxidation in the outer stripe. In the inner stripe furosemide tended to increase cytochrome oxidation, and saralasin had no effect. These results indicate that the two regions of the outer medulla may be affected differently by the same agent. They suggest that cytochrome oxidation in the outer stripe is predominantly influenced by outer medullary blood flow, whereas the inner stripe is predominantly influenced by the rate of oxygen consumption. The advantages and limitations of this methodology are discussed. RP ATKINS, JL (reprint author), WALTER REED ARMY MED CTR,DIV MED,DEPT NEPHROL,BLDG 40,ROOM 3035,WASHINGTON,DC 20307, USA. NR 27 TC 12 Z9 12 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0002-9513 J9 AM J PHYSIOL JI Am. J. Physiol. PD NOV PY 1991 VL 261 IS 5 BP F849 EP F857 PN 2 PG 9 WC Physiology SC Physiology GA GQ781 UT WOS:A1991GQ78100097 PM 1951716 ER PT J AU ARONSON, NE SILVERMAN, C WASSERMAN, GF KOCHAN, J HALL, BT ESSER, K YOUNG, JE CHULAY, JD AF ARONSON, NE SILVERMAN, C WASSERMAN, GF KOCHAN, J HALL, BT ESSER, K YOUNG, JE CHULAY, JD TI IMMUNIZATION OF OWL MONKEYS WITH A RECOMBINANT PROTEIN CONTAINING REPEATED EPITOPES OF A PLASMODIUM-FALCIPARUM GLYCOPHORIN-BINDING PROTEIN SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID ERYTHROCYTE SURFACE-ANTIGEN; ASEXUAL BLOOD STAGES; PROTECTIVE IMMUNITY; SYNTHETIC PEPTIDES; MALARIA PARASITE; INVITRO GROWTH; AOTUS MONKEYS; MEROZOITES; RECEPTOR; INVASION AB A Plasmodium falciparum glycophorin binding protein (GBP-130) has been implicated in protective immunity to malaria. The gene for GBP-130 encodes a protein containing 11 tandemly repetitive 50 amino acid units. We report an immunization trial in Aotus monkeys using a recombinant DNA protein containing three of these 50 amino acid repeats. When administered with aluminum hydroxide, this antigen induced low levels of antibodies that reacted with the recombinant protein by ELISA and with parasite antigens in immunoblot and immunofluorescence assays, but not by immunoprecipitation. When administered with Freund's complete adjuvant, this antigen induced high levels of antibodies that reacted in ELISA, immunoblot, immunofluorescence, and immunoprecipitation assays. Serum from immunized monkeys did not inhibit parasite growth, and protection from intravenous challenge with P. falciparum-infected erythrocytes was not observed in any experimental group. These results suggest that the repetitive region of GBP-130 is not a useful vaccine candidate. C1 WALTER REED ARMY MED CTR,DEPT IMMUNOL,WASHINGTON,DC 20307. SMITH KLINE BEECHAM PHARMACEUT,KING OF PRUSSIA,PA 19406. MEM SLOAN KETTERING CANC CTR,DEWITT WALLACE RES LAB,NEW YORK,NY 10021. RP ARONSON, NE (reprint author), WALTER REED ARMY MED CTR,INFECT DIS SERV,WASHINGTON,DC 20307, USA. NR 42 TC 8 Z9 8 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 1991 VL 45 IS 5 BP 548 EP 559 PG 12 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA GR917 UT WOS:A1991GR91700003 PM 1719834 ER PT J AU BROWN, AE WEBSTER, HK LYON, JA THOMAS, AW PERMPANICH, B GROSS, M AF BROWN, AE WEBSTER, HK LYON, JA THOMAS, AW PERMPANICH, B GROSS, M TI CHARACTERIZATION OF NATURALLY ACQUIRED ANTIBODY-RESPONSES TO A RECOMBINANT FRAGMENT FROM THE N-TERMINUS OF PLASMODIUM-FALCIPARUM GLYCOPROTEIN-195 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID SURFACE-ANTIGEN; MALARIA; MEROZOITES; PRECURSOR; SEROLOGY; GENE AB Antibody responses to the glycoprotein precursor of the major merozoite surface antigens of Plasmodium falciparum (gp195) were investigated in acutely infected Thai adults. Specific IgG antibody was assayed by enzyme-linked immunosorbent assay using a recombinant fragment derived from the N-terminal region of gp195 as the capture antigen. Two control groups were found to be without significant cross-reacting antibody. Among occupationally exposed soldiers, 84 of 85 men developed positive antibody responses during acute falciparum malaria. Mean antibody levels began to increase at the time of diagnosis, peaking, often at high liters, within two weeks, and then decreased with an initial serum half-life of less than one month. The high frequency of gp195 antibody responses underscores a potential role in serodiagnosis, whereas the dynamic nature of the response suggests that a rigorous schedule of prospective serum sampling will be required to accurately assess the relationship between these antibodies and protection. C1 WALTER REED ARMY MED CTR,DEPT IMMUNOL,WASHINGTON,DC 20307. SMITH KLINE & BECKMAN LABS,DEPT MOLEC GENET,KING OF PRUSSIA,PA 19406. RP BROWN, AE (reprint author), ARMED FORCES RES INST MED SCI,DEPT IMMUNOL,315-6 RAJVITHI RD,BANGKOK 10400,THAILAND. NR 17 TC 10 Z9 10 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 1991 VL 45 IS 5 BP 567 EP 573 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA GR917 UT WOS:A1991GR91700005 PM 1951865 ER PT J AU KLAYMAN, DL AGER, AL FLECKENSTEIN, L LIN, AJ AF KLAYMAN, DL AGER, AL FLECKENSTEIN, L LIN, AJ TI TRANSDERMAL ARTELINIC ACID - AN EFFECTIVE TREATMENT FOR PLASMODIUM-BERGHEI-INFECTED MICE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID ARTEMISININ AB Artelinic acid, a derivative of the naturally occurring antimalarial artemisinin, has been incorporated into a gel suitable for transdermal administration. The formulation was tested for efficacy in Plasmodium berghei-infected mice for both curative and prophylactic properties by application to their partially denuded backs, beginning on days 3 and 0, respectively, after injection of parasitized erythrocytes. In the curative experiments, rapid elimination of the parasitemia and 60-day survival of five of five mice was achieved by dermal application of gel containing 0.9 mg of artelinic acid that was administered twice a day, beginning on day 3 after infection, for three days (total dosage of 270 mg/kg). In the prophylactic trials, the establishment of parasitemia was prevented and 60-day survival was achieved in five of five mice at a dose of 0.9 mg of artelinic acid administered twice a day, beginning on the day of inoculation, for two days (total dosage of 180 mg/kg). The transdermal medium, with or without drug, caused no topical or systemic toxicity. C1 UNIV MIAMI,CTR TROP PARASIT DIS,MIAMI,FL 33177. RP KLAYMAN, DL (reprint author), WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. OI Fleckenstein, Lawrence/0000-0001-5320-4531 NR 11 TC 13 Z9 13 U1 0 U2 5 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 1991 VL 45 IS 5 BP 602 EP 607 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA GR917 UT WOS:A1991GR91700010 PM 1951870 ER PT J AU REYNOLDS, PC ANTOINE, JA BETTENCOURT, J STARCK, TW AF REYNOLDS, PC ANTOINE, JA BETTENCOURT, J STARCK, TW TI REGIONAL HYPOTHERMIA AFFECTS SOMATOSENSORY EVOKED-POTENTIALS SO ANESTHESIA AND ANALGESIA LA English DT Article RP REYNOLDS, PC (reprint author), WALTER REED ARMY MED CTR,DEPT SURG,ANESTHESIA & OPERAT SERV,WASHINGTON,DC 20307, USA. NR 12 TC 8 Z9 8 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD NOV PY 1991 VL 73 IS 5 BP 653 EP 656 PG 4 WC Anesthesiology SC Anesthesiology GA GL865 UT WOS:A1991GL86500026 PM 1952151 ER PT J AU MELLGREN, RL ELSMORE, TF AF MELLGREN, RL ELSMORE, TF TI EXTINCTION OF OPERANT-BEHAVIOR - AN ANALYSIS BASED ON FORAGING CONSIDERATIONS SO ANIMAL LEARNING & BEHAVIOR LA English DT Article ID PARTIAL-REINFORCEMENT; RADIAL MAZE; SCHEDULES; LOCATION; MOMENTUM; CHOICE; FOOD AB In two experiments, the frequency of food reinforcement provided by variable interval (VI) schedules prior to extinction was varied. In the first experiment, two-component multiple schedules resulted in a greater number of responses in extinction in the presence of the stimulus previously associated with the richer of the two component schedules than that previously associated with the leaner schedule. In the second experiment, different groups of animals were trained on different VI schedules. Responding in extinction was analyzed into bouts of responding showing that the number of response bouts increased and the number of responses per bout decreased with decreasing frequency of reinforcement during training. These data are compatible with an analysis of operant behavior based on an analogy to processes that presumably occur in naturalistic foraging situations. According to this analogy, behavior associated with search for a food source (i.e., number of response bouts) and that of procurement of food from a source (i.e., responses per bout) represent aspects of behavior that are differentially strengthened by different VI schedules. Extinction serves to reveal this differential strengthening. C1 WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,WASHINGTON,DC 20307. RP MELLGREN, RL (reprint author), UNIV TEXAS,DEPT PSYCHOL,BOX 19528,ARLINGTON,TX 76019, USA. NR 36 TC 21 Z9 21 U1 0 U2 2 PU PSYCHONOMIC SOC INC PI AUSTIN PA 1710 FORTVIEW RD, AUSTIN, TX 78704 SN 0090-4996 J9 ANIM LEARN BEHAV JI Anim. Learn. Behav. PD NOV PY 1991 VL 19 IS 4 BP 317 EP 325 DI 10.3758/BF03197892 PG 9 WC Psychology, Biological; Behavioral Sciences; Psychology, Experimental; Zoology SC Psychology; Behavioral Sciences; Zoology GA GQ427 UT WOS:A1991GQ42700003 ER PT J AU KORTEPETER, MG AF KORTEPETER, MG TI MRI - MY RESONANT IMAGE SO ANNALS OF INTERNAL MEDICINE LA English DT Letter RP KORTEPETER, MG (reprint author), TRIPLER ARMY MED CTR,HONOLULU,HI 96859, USA. NR 0 TC 5 Z9 5 U1 0 U2 0 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD NOV 1 PY 1991 VL 115 IS 9 BP 749 EP 750 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA GL697 UT WOS:A1991GL69700031 PM 1929047 ER PT J AU ADEBONOJO, SA NOVA, G VISWESHWAR, IN AF ADEBONOJO, SA NOVA, G VISWESHWAR, IN TI WHITE CLOT SYNDROME HEPARIN-INDUCED PLATELET-AGGREGATION - A CASE-REPORT SO ANNALS OF SAUDI MEDICINE LA English DT Article RP ADEBONOJO, SA (reprint author), WALTER REED ARMY MED CTR,DEPT THORAC SURG,WASHINGTON,DC 20307, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU K FAISAL SPEC HOSP RES CENTRE PI RIYADH PA PUBLICATIONS OFFICE PO BOX 3354, RIYADH 11211, SAUDI ARABIA SN 0256-4947 J9 ANN SAUDI MED JI Ann. Saudi Med. PD NOV PY 1991 VL 11 IS 6 BP 698 EP 700 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA GN843 UT WOS:A1991GN84300020 PM 17590826 ER PT J AU EDWARDS, FH HALE, D COHEN, A THOMPSON, L PEZZELLA, AT VIRMANI, R AF EDWARDS, FH HALE, D COHEN, A THOMPSON, L PEZZELLA, AT VIRMANI, R TI PRIMARY CARDIAC-VALVE TUMORS SO ANNALS OF THORACIC SURGERY LA English DT Article ID PAPILLARY FIBROELASTOMA; SURGICAL-TREATMENT; EXCISION; MYXOMAS; STROKE AB To investigate the characteristics of primary cardiac valve tumors, we retrospectively analyzed our multiinstitutional experience from 1932 through 1990. We encountered 56 valvular tumors in 53 patients. The average age of these patients was 52 years (range, 2 to 88 years) and 79% (42/53) were male. Symptoms were present in 38% (20/53) and were neurological in 15% (8/53). Four patients experienced sudden death. Each of the four valves was affected with approximately equal frequency: 16 aortic, 15 mitral, 13 pulmonary, and 12 tricuspid. All but four tumors were benign. The most common histological type was papillary fibroelastoma (41%), followed by myxomas (5), fibromas (4), sarcomas (2), hamartoma (1), hemangioma (1), histiocytoma (1), and undifferentiated (1). Average tumor size was 1.15 cm (range, 3 mm to 7 cm), and the average size of fibroelastomas was 8 mm (range, 3 to 15 mm). Mitral valve tumors were more likely than aortic valve tumors to produce serious neurological symptoms or sudden death (8/15 versus 3/16; p < 0.05). Six patients underwent echocardiography, and results were positive in each. All 6 underwent uncomplicated valve repair or replacement. Compared with a series of 407 nonvalvular tumors, cardiac valve tumors are more likely to occur in male patients (p < 0.001) and adults (p < 0.001). Valve tumors are also more commonly benign (p < 0.001) and asymptomatic (p < 0.001). These tumors demonstrate somewhat less aggressive behavior compared with nonvalvular tumors, but their distinct propensity to produce serious clinical sequelae argues in favor of surgical resection for all cardiac valve tumors. C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. ARMED FORCES INST PATHOL,WASHINGTON,DC 20306. RP EDWARDS, FH (reprint author), WALTER REED ARMY MED CTR,DEPT SURG,WASHINGTON,DC 20307, USA. NR 17 TC 203 Z9 207 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0003-4975 J9 ANN THORAC SURG JI Ann. Thorac. Surg. PD NOV PY 1991 VL 52 IS 5 BP 1127 EP 1131 PG 5 WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery SC Cardiovascular System & Cardiology; Respiratory System; Surgery GA GP868 UT WOS:A1991GP86800017 PM 1953134 ER PT J AU KARLE, JM KARLE, IL AF KARLE, JM KARLE, IL TI CRYSTAL-STRUCTURE AND MOLECULAR-STRUCTURE OF MEFLOQUINE METHYLSULFONATE MONOHYDRATE - IMPLICATIONS FOR A MALARIA RECEPTOR SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID PLASMODIUM-FALCIPARUM; RESISTANCE; QUINIDINE; THAILAND AB The crystal structure of (+/-)-mefloquine methylsulfonate monohydrate was determined by X-ray diffraction and was compared with the crystal structures of mefloquine hydrochloride and mefloquine free base. The conformation of mefloquine was essentially the same in all three crystalline environments and was not dependent on whether mefloquine was a salt or a free base. In mefloquine methylsulfonate monohydrate, the angle between the average plane of the quinoline ring and the average plane of the piperidine ring was 76.9-degrees. The intramolecular aliphatic N-13 . . . O-1 distance was 2.730 +/- 0.008 angstrom (1 angstrom = 0.1 nm), which is close to the aliphatic N . . . O distance found in the antimalarial cinchona alkaloids. The hydrogen bonds with two different hydrogen bond with the water molecule, and the amine group formed hydrogen bonds with two different methylsulfonate ions. The crystallographic parameters for (+/-)-mefloquine methylsufonate monohydrate were as follows: C17H17F6N2O+ . CH3SO3- . H2O; M(r) = 492.4; symmetry of unit cell, monoclinic; space group, P2(1)/a; parameters of unit cell, a was 8.678 +/- 0.001 angstrom, b was 28.330 +/- 0.003 angstrom, c was 8.804 +/- 0.001 angstrom, beta was 97.50 +/- 0.01-degrees; the volume of the unit cell was 2145.9 angstrom 3; the number of molecules per unit cell was 4; the calculated density was 1.52 g cm-3; the source of radiation was Cu K-alpha (lambda = 1.54178 angstrom); mu (absorption coefficient) was 20.46 cm-1; F(000) (sum of atomic scattering factors at zero scattering angle) was 1,016; room temperature was used; and the final R (residual index) was 6.58% for 1,740 reflections with \ F(o) \ > 3-sigma (F). Since the mechanism of antimalarial action and the mechanism of mefloquine resistance may involve hydrogen bond formation between mefloquine and a cellular effector or transport proteins, the common conformation of mefloquine found in each crystalline environment may define the orientation in which mefloquine forms these potentially critical hydrogen bonds with cellular constituents. C1 USN,RES LAB,STRUCT MATTER LAB,WASHINGTON,DC 20375. RP KARLE, JM (reprint author), WALTER REED ARMY MED CTR,DEPT PHARMACOL,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 27 TC 23 Z9 23 U1 0 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD NOV PY 1991 VL 35 IS 11 BP 2238 EP 2245 PG 8 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA GM872 UT WOS:A1991GM87200013 PM 1803997 ER PT J AU SMITH, KJ SKELTON, HG LUPTON, GP PALOMINO, NJ AF SMITH, KJ SKELTON, HG LUPTON, GP PALOMINO, NJ TI ADENOCARCINOMA ARISING IN A SEBORRHEIC KERATOSIS SO ARCHIVES OF DERMATOLOGY LA English DT Letter ID SQUAMOUS-CELL CARCINOMA; BOWENS DISEASE; INSITU C1 ARMED FORCES INST PATHOL, DEPT DERMATOPATHOL, WASHINGTON, DC 20306 USA. MIAMI VALLEY HOSP, DEPT PATHOL, DAYTON, OH 45409 USA. RP SMITH, KJ (reprint author), WALTER REED ARMY MED CTR, DEPT DERMATOL, WASHINGTON, DC 20307 USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 0003-987X EI 1538-3652 J9 ARCH DERMATOL JI Arch. Dermatol. PD NOV PY 1991 VL 127 IS 11 BP 1738 EP 1739 DI 10.1001/archderm.127.11.1738 PG 2 WC Dermatology SC Dermatology GA GQ249 UT WOS:A1991GQ24900031 ER PT J AU GARDNER, TA RAK, KM AF GARDNER, TA RAK, KM TI MAGNETIC-RESONANCE-IMAGING OF EYELID SPRINGS AND GOLD WEIGHTS SO ARCHIVES OF OPHTHALMOLOGY LA English DT Letter RP GARDNER, TA (reprint author), USA,AURORA,CO, USA. NR 2 TC 4 Z9 4 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-9950 J9 ARCH OPHTHALMOL-CHIC JI Arch. Ophthalmol. PD NOV PY 1991 VL 109 IS 11 BP 1498 EP 1498 PG 1 WC Ophthalmology SC Ophthalmology GA GP106 UT WOS:A1991GP10600019 PM 1755723 ER PT J AU SHIH, ML SMITH, JR MCMONAGLE, JD DOLZINE, TW GRESHAM, VC AF SHIH, ML SMITH, JR MCMONAGLE, JD DOLZINE, TW GRESHAM, VC TI DETECTION OF METABOLITES OF TOXIC ALKYLMETHYLPHOSPHONATES IN BIOLOGICAL SAMPLES SO BIOLOGICAL MASS SPECTROMETRY LA English DT Article ID MASS-SPECTROMETRY; METHYLPHOSPHONIC ACIDS; CHEMICAL IONIZATION AB The major metabolites and breakdown products of some toxic organophosphonates are their respective alkylmethylphosphonic acids. These acids ionize at physiological pH and are not amenable to gas chromatographic analysis in their underivatized forms. Their detection in biological samples has been difficult because of their presence at only trace levels. Existing analytical methods were developed mainly for measuring these phosphonic acids in environmental samples and at higher concentrations. In this study, we devised a gas chromatographic/mass spectrometric method to provide confirmation and quantification of the organophosphonic acids of soman (GD), sarin (GB) and GF in blood and urine. This report describes the various derivatization conditions that we have studied and demonstrates the characteristic mass spectra by different ionization techniques. RP SHIH, ML (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 18 TC 75 Z9 76 U1 2 U2 7 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 1052-9306 J9 BIOL MASS SPECTROM JI Biol. Mass Spectrom. PD NOV PY 1991 VL 20 IS 11 BP 717 EP 723 DI 10.1002/bms.1200201111 PG 7 WC Biophysics; Spectroscopy SC Biophysics; Spectroscopy GA GM600 UT WOS:A1991GM60000010 PM 1799583 ER PT J AU DIEHL, VA MOU, LC MILLS, CB BIRKMIRE, DP AF DIEHL, VA MOU, LC MILLS, CB BIRKMIRE, DP TI THE EFFECT OF PURPOSE FOR READING A PROCEDURE ON PERFORMANCE-MEASURES SO BULLETIN OF THE PSYCHONOMIC SOCIETY LA English DT Meeting Abstract C1 WESTERN ILLINOIS UNIV,MACOMB,IL 61455. UNIV MARYLAND,COLLEGE PK,MD 20742. GOUCHER COLL,TOWSON,MD 21204. AMER INST RES,WASHINGTON,DC. USA,HUMAN ENGN LAB,WASHINGTON,DC 20310. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PSYCHONOMIC SOC INC PI AUSTIN PA 1710 FORTVIEW RD, AUSTIN, TX 78704 SN 0090-5054 J9 B PSYCHONOMIC SOC PD NOV PY 1991 VL 29 IS 6 BP 490 EP 490 PG 1 WC Psychology, Mathematical SC Psychology GA GL115 UT WOS:A1991GL11500201 ER PT J AU STEPHENS, RL PEARSON, JY SISSON, MD AF STEPHENS, RL PEARSON, JY SISSON, MD TI AUTOMATICITY OF INFORMATION EXTRACTION FROM TACHISTOSCOPIC DISPLAYS SO BULLETIN OF THE PSYCHONOMIC SOCIETY LA English DT Meeting Abstract C1 USA,AEROMED RES LAB,WASHINGTON,DC 20310. NR 0 TC 0 Z9 0 U1 0 U2 1 PU PSYCHONOMIC SOC INC PI AUSTIN PA 1710 FORTVIEW RD, AUSTIN, TX 78704 SN 0090-5054 J9 B PSYCHONOMIC SOC PD NOV PY 1991 VL 29 IS 6 BP 493 EP 493 PG 1 WC Psychology, Mathematical SC Psychology GA GL115 UT WOS:A1991GL11500233 ER PT J AU SHANTEAU, J PHELPS, RH AF SHANTEAU, J PHELPS, RH TI EXPERT VERSUS NOVICE DECISION MAKERS - ITS NOT HOW MUCH INFORMATION BUT WHAT KIND OF INFORMATION THAT MATTERS SO BULLETIN OF THE PSYCHONOMIC SOCIETY LA English DT Meeting Abstract C1 KANSAS STATE UNIV AGR & APPL SCI,MANHATTAN,KS 66506. USA,RES INST,BOISE,ID. NR 0 TC 0 Z9 0 U1 0 U2 1 PU PSYCHONOMIC SOC INC PI AUSTIN PA 1710 FORTVIEW RD, AUSTIN, TX 78704 SN 0090-5054 J9 B PSYCHONOMIC SOC PD NOV PY 1991 VL 29 IS 6 BP 527 EP 527 PG 1 WC Psychology, Mathematical SC Psychology GA GL115 UT WOS:A1991GL11500592 ER PT J AU MILLS, CB DIEHL, VA MOU, LC BIRKMIRE, DP AF MILLS, CB DIEHL, VA MOU, LC BIRKMIRE, DP TI EFFECT OF READING STRATEGIES FOR PROCEDURAL TEXT ON RECALL, COMPREHENSION, AND TASK-PERFORMANCE SO BULLETIN OF THE PSYCHONOMIC SOCIETY LA English DT Meeting Abstract C1 WESTERN ILLINOIS UNIV,MACOMB,IL 61455. UNIV MARYLAND,COLLEGE PK,MD 20742. USA,HUMAN ENGN LAB,WASHINGTON,DC 20310. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PSYCHONOMIC SOC INC PI AUSTIN PA 1710 FORTVIEW RD, AUSTIN, TX 78704 SN 0090-5054 J9 B PSYCHONOMIC SOC PD NOV PY 1991 VL 29 IS 6 BP 529 EP 529 PG 1 WC Psychology, Mathematical SC Psychology GA GL115 UT WOS:A1991GL11500619 ER PT J AU BRENNAN, MJ DUNCAN, WE WARTOFSKY, L BUTLER, VM WRAY, HL AF BRENNAN, MJ DUNCAN, WE WARTOFSKY, L BUTLER, VM WRAY, HL TI INVITRO DISSOLUTION OF CALCIUM-CARBONATE PREPARATIONS SO CALCIFIED TISSUE INTERNATIONAL LA English DT Article DE CALCIUM; DISSOLUTION; CALCIUM CARBONATE ID POSTMENOPAUSAL BONE LOSS; ABSORPTION; CITRATE; WOMEN; SUPPLEMENTATION; BIOAVAILABILITY; ABSORBABILITY; ACHLORHYDRIA; TRIAL; MILK AB Calcium supplements are widely used for the treatment of osteoporosis. The bioavailability of these preparations is unknown. Because poor tablet dissolution accounts for a majority of drug bioavailability problems, we determined the in vitro dissolution at 30, 60, and 90 minutes of 27 commercially available calcium carbonate supplements using the method of the U.S. Pharmacopoiea. At 30 minutes, five preparations (18%) were more than 75% dissolved, four (15%) between 33 and 74%, and the remaining 18 (67%) were less than 33% dissolved. After 90 minutes, 17 (63%) of the preparations were less than 50% dissolved. Dissolution correlated negatively with the weight of filler (noncalcium carbonate material in the tablet) (r(s) = 0.51, P < 0.01) but not with tablet hardness or cost. Similar to previous studies, we also found no correlation of dissolution with the stated calcium content, chemical source of calcium carbonate (oyster shell or chemical precipitate), or retail source. We conclude that there is a wide range of in vitro dissolution among the calcium carbonate preparations tested, and that the filler is an important determinant of the dissolution of these tablets. These results raise concern about the bioavailability of the calcium in these preparations and may have important implications for the therapeutic use of the various calcium carbonate supplements. C1 WALTER REED ARMY MED CTR,ENDOCRINE METAB SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT MED,KYLE METAB UNIT,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,KYLE METAB UNIT,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. NR 33 TC 16 Z9 17 U1 0 U2 3 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0171-967X J9 CALCIFIED TISSUE INT JI Calcif. Tissue Int. PD NOV PY 1991 VL 49 IS 5 BP 308 EP 312 DI 10.1007/BF02556251 PG 5 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA GJ723 UT WOS:A1991GJ72300004 PM 1782571 ER PT J AU JALALIHERAVI, M MCMANUS, SP ZUTAUT, SE MCDONALD, JK AF JALALIHERAVI, M MCMANUS, SP ZUTAUT, SE MCDONALD, JK TI SEMIEMPIRICAL SCF-MO MODELING OF POLYSILANES USING AM1 AND PM3 METHODS SO CHEMISTRY OF MATERIALS LA English DT Article ID CHAIN CONFORMATIONAL KINETICS; ORGANOSILANE HIGH POLYMERS; IONIZATION-POTENTIALS; SPECTROSCOPIC METHODS; POLY(DI-NORMAL-HEXYLSILANE); POLY(DI-NORMAL-ALKYLSILANES); OPTIMIZATION; TRANSITION; PARAMETERS; ABINITIO AB AM1 and PM3 semiempirical SCF-MO methods have been used to calculate structures and properties of model polysilanes. Bond lengths and molecular orbital energies of poly(hydrosilanes) calculated by both methods are in good agreement with ab initio results, but bond angles deviate slightly. Our studies of molecular geometry and electronic properties of polysilane models show similar behavior for the AM1 and PM3 methods in most cases, but the PM3 method appears to be superior in predicting bandgaps. The PM3 method predicts that the anti conformer of Si4(CH3)10 lies almost-equal-to 1.0 kcal/mol lower in energy than the gauche conformer. Studies evaluating polysilanes bearing substituent groups with different steric requirements and electronic properties (Me, Et, F, Cl, and OCH3) were instructive. Compared to the unsubstituted model, all of the substituted polysilanes have larger Si-Si bond angles, in agreement with experiment. Our calculations suggest that substituents may have a significant effect on Si-Si-Si bond angles pushing them to well above the 120-degrees value estimated for the hexyl derivative from X-ray data. The effect of substitution on electronic properties is predicted to be complicated. For calculation of structure and properties of polysilane models overall, the AM1 and PM3 methods are judged to provide excellent agreement with experimental data and ab initio methods. C1 UNIV ALABAMA,DEPT CHEM,HUNTSVILLE,AL 35899. USA,MISSILE COMMAND,CTR RES DEV & ENGN,WEAPONS SCI DIRECTORATE,REDSTONE ARSENAL,AL 35898. NR 37 TC 17 Z9 17 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0897-4756 J9 CHEM MATER JI Chem. Mat. PD NOV-DEC PY 1991 VL 3 IS 6 BP 1024 EP 1030 DI 10.1021/cm00018a016 PG 7 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA GR966 UT WOS:A1991GR96600016 ER PT J AU TENHOLDER, MF RAJAGOPAL, KR PHILLIPS, YY DILLARD, TA BENNETT, LL MUNDIE, TG TELLIS, CJ AF TENHOLDER, MF RAJAGOPAL, KR PHILLIPS, YY DILLARD, TA BENNETT, LL MUNDIE, TG TELLIS, CJ TI URINARY DESMOSINE EXCRETION AS A MARKER OF LUNG INJURY IN THE ADULT RESPIRATORY-DISTRESS SYNDROME SO CHEST LA English DT Article ID ANGIOTENSIN-CONVERTING ENZYME; ELASTIN CROSS-LINKS; BRONCHOALVEOLAR LAVAGE; NEUTROPHIL ELASTASE; RADIOIMMUNOASSAY; FLUID; SHEEP; ARDS AB Desmosine, the intermolecular and intramolecular cross link between the chains of elastin polypeptide, may be useful as a marker of a lung injury in adult respiratory distress syndrome (ARDS). A radioimmunoassay for rabbit antibody developed against desmosine, conjugated to bovine serum albumin, can detect as little as 100 pg of desmosine in plasma or urine. Desmosine is not metabolically absorbed, reused, or catabolized by the body, but rather eliminated unchanged in the urine as low molecular weight peptides. The lung is relatively rich in elastin, and we reasoned that a timed collection could be used as an index of elastin degradation in vivo. A 2-b collection of urine for desmosine assay was obtained at the time of Swan-Ganz catheter insertion in 41 consecutive patients. On the basis of clinical and initial Swan-Ganz catheter data, the patients were assigned to one of three groups: an ARDS group (n = 12); a cardiogenic pulmonary edema (CPE) group (n = 12); and a critically ill, nonpulmonary edema group (NPE, n = 17). The mean urine desmosine concentration (mg/L) for the ARDS group (0. 728 +/- 0.22 SE) differed from the CPE group (0. 149 +/- 0.07; p < 0.001). The total excretion (mu-g/2 h) was 64.95 +/- 24.7 in the ARDS group and 24.71 +/- 11.7 in the CPE group (p < 0.05). Urine desmosine concentration/serum creatinine index for the ARDS group (0.78 +/- 0.28) was greater than in the CPE group (0.07 +/- 0.04; p = 0.019). Desmosine excretion was increased in the NPE group compared with CPE and ARDS groups, possibly reflecting heterogeneity in this group. In the differentiation of ARDS from CPE, we conclude that substantial increases in urinary desmosine excretion favor a diagnosis of ARDS. C1 WALTER REED ARMY MED CTR,DEPT MED,PULM & CRIT CARE MED SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,PULM SERV,BETHESDA,MD 20814. NR 20 TC 23 Z9 24 U1 0 U2 2 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD NOV PY 1991 VL 100 IS 5 BP 1385 EP 1390 DI 10.1378/chest.100.5.1385 PG 6 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA GN722 UT WOS:A1991GN72200041 PM 1935298 ER PT J AU MARTEL, CJ AF MARTEL, CJ TI FREEZING OUT SLUDGE SO CIVIL ENGINEERING LA English DT Article RP MARTEL, CJ (reprint author), USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0885-7024 J9 CIVIL ENG JI Civil Eng. PD NOV PY 1991 VL 61 IS 11 BP 64 EP 65 PG 2 WC Engineering, Civil SC Engineering GA GM509 UT WOS:A1991GM50900020 ER PT J AU LEVER, JH KLEIN, K MITCHELL, D DIEMAND, D AF LEVER, JH KLEIN, K MITCHELL, D DIEMAND, D TI WAVE-INDUCED ICEBERG MOTION SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article AB This paper describes the results of a three-year field study to measure the wave-induced motion of icebergs. We sought this information to examine how well iceberg velocities, derived using wave-tank tests, reflect those of irregularly shaped full-scale icebergs. We deployed self-contained motion-monitoring packages on icebergs in the Labrador Sea and on the Grand Banks, and obtained 19 data sets of wave-induced iceberg motion. To our knowledge, these are the only available data describing the wave-induced motion of full-scale icebergs in six degrees-of-freedom. For comparison with laboratory results, we computed normalized significant surge and heave iceberg velocities and plotted these against normalized peak wavelength. This demonstrated that velocities based on wave-tank study of four regularly shaped model icebergs do reflect the range of variation in iceberg motion attributable to random shape. The paper concludes that iceberg significant velocities are random quantities for a given size iceberg in a given sea state, and that a gamma probability density, fitted to wave-tank results, is suitable for describing their variations. C1 MEM UNIV NEWFOUNDLAND,CTR COLD OCEANS RESOURCES ENGN,ST JOHNS A1C 5S7,NEWFOUNDLAND,CANADA. MEM UNIV NEWFOUNDLAND,FAC ENGN & APPL SCI,ST JOHNS A1C 5S7,NEWFOUNDLAND,CANADA. RP LEVER, JH (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 16 TC 4 Z9 4 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD NOV PY 1991 VL 20 IS 1 BP 11 EP 23 DI 10.1016/0165-232X(91)90053-J PG 13 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA GT110 UT WOS:A1991GT11000003 ER PT J AU DUNCAN, WE GLASS, AR WRAY, HL AF DUNCAN, WE GLASS, AR WRAY, HL TI ESTROGEN REGULATION OF THE NUCLEAR 1,25-DIHYDROXYVITAMIN-D3 RECEPTOR IN RAT-LIVER AND KIDNEY SO ENDOCRINOLOGY LA English DT Article ID OSTEOBLAST-LIKE CELLS; VITAMIN-D; MESSENGER-RNA; EXPRESSION; HORMONES; PROTEIN; BINDING; UTERUS; CHICK; REGENERATION AB We previously identified a receptor protein for 1,25-dihydroxyvitamin D3 in rat liver nuclei. The present studies were undertaken to investigate the ontogenesis of the hepatic nuclear vitamin D receptor (nVDR) and the estrogen regulation of this receptor in the liver, small intestine, and kidneys. The hepatic nVDR was significantly elevated in adult female rats compared to prepubertal female rats, while in male rats, this increase was not observed. Oophorectomized rats contained significantly less hepatic nVDR than did intact female rats. Administration of estradiol to castrated male or oophorectomized rats increased the hepatic nVDR. Further studies demonstrated that the increase in the hepatic nVDR was observed only after 2 weeks of estradiol treatment and was positively correlated with circulating estradiol concentrations. Castration of male rats did not alter the hepatic nVDR compared to intact male rats nor did testosterone administration to castrated male rats for 4 weeks change the hepatic nVDR concentration. Unlike the liver, intact female rats contained significantly less renal nVDR than did kidneys from intact male or castrated male rats. Estradiol administration to oophorectomized rats significantly decreased the renal nVDR. Renal nVDR concentrations correlated inversely with the serum concentration of estradiol. Castration of male rats had no effect on the renal nVDR. Intestinal nVDR concentrations were unaffected by castration of male rats or by treatment of castrated male rats with estrogen for up to 4 weeks. These results indicate that estradiol increases the nVDR in liver, decreases the nVDR in kidney and does not change the nVDR in the intestine. Physiological concentrations of testosterone do not regulate the nVDR in these tissues. Estradiol regulation of this receptor is organ specific and, therefore, conclusions about the regulation of the nVDR in one tissue cannot be extrapolated to other tissues. C1 WALTER REED ARMY MED CTR, DEPT MED, KYLE METAB UNIT, WASHINGTON, DC 20307 USA. WALTER REED ARMY MED CTR, DEPT CLIN INVEST, WASHINGTON, DC 20307 USA. UNIFORMED SERV UNIV HLTH SCI, DEPT MED, BETHESDA, MD 20814 USA. RP WALTER REED ARMY MED CTR, DEPT MED, ENDOCRINE METAB SERV 7D, WASHINGTON, DC 20307 USA. NR 44 TC 35 Z9 36 U1 0 U2 1 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0013-7227 EI 1945-7170 J9 ENDOCRINOLOGY JI Endocrinology PD NOV PY 1991 VL 129 IS 5 BP 2318 EP 2324 PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA GM349 UT WOS:A1991GM34900009 PM 1657571 ER PT J AU YOUNG, AJ YOUNG, PM MCCULLOUGH, RE MOORE, LG CYMERMAN, A REEVES, JT AF YOUNG, AJ YOUNG, PM MCCULLOUGH, RE MOORE, LG CYMERMAN, A REEVES, JT TI EFFECT OF BETA-ADRENERGIC-BLOCKADE ON PLASMA LACTATE CONCENTRATION DURING EXERCISE AT HIGH-ALTITUDE SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY LA English DT Article DE ACCLIMATIZATION; ALTITUDE; HYPOXIA; CATECHOLAMINES; PROPRANOLOL ID OXYGEN-UPTAKE; CATECHOLAMINES; EXPOSURE; SERUM; MEN AB When unacclimatized lowlanders exercise at high altitude, blood lactate concentration rises higher than at sea level, but lactate accumulation is attenuated after acclimatization. These responses could result from the effects of acute and chronic hypoxia on beta-adrenergic stimulation. In this investigation, the effects of beta-adrenergic blockade on blood lactate and other metabolites were studied in lowland residents during 30 min of steady-state exercise at sea level and on days 3, 8, and 20 of residence at 4300 m. Starting 3 days before ascent and through day 15 at high altitude, six men received propranolol (80 mg three times daily) and six received placebo. Plasma lactate accumulation was reduced in propranolol- but not placebo-treated subjects during exercise on day 3 at high altitude compared to sea-level exercise of the same percentage maximal oxygen uptake (VO2max). Plasma lactate accumulation exercise on day 20 at high altitude was reduced in both placebo- and propranolol-treated subjects compared to exercise of the same percentage VO2max performed at sea level. The blunted lactate accumulation during exercise on day 20 at high altitude was associated with reduced muscle glycogen utilization. Thus, increased plasma lactate accumulation in unacclimatized low-landers exercising at high altitude appears to be due to increased beta-adrenergic stimulation. However, acclimatization-induced changes in muscle glycogen utilization and plasma lactate accumulation are not adaptations to chronically increased beta-adrenergic activity. C1 UNIV COLORADO,CARDIOVASC PULM LAB,DENVER,CO 80202. RP YOUNG, AJ (reprint author), USA,ENVIRONM MED RES INST,NATICK,MA 01760, USA. NR 28 TC 20 Z9 20 U1 0 U2 1 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0301-5548 J9 EUR J APPL PHYSIOL O JI Eur. J. Appl. Physiol. Occup. Physiol. PD NOV PY 1991 VL 63 IS 5 BP 315 EP 322 DI 10.1007/BF00364456 PG 8 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA GR529 UT WOS:A1991GR52900001 PM 1685447 ER PT J AU LETTERIE, GS SAKAS, EL AF LETTERIE, GS SAKAS, EL TI HISTOLOGY OF PROXIMAL TUBAL OBSTRUCTION IN CASES OF UNSUCCESSFUL TUBAL CANALIZATION SO FERTILITY AND STERILITY LA English DT Article ID RECANALIZATION; DISEASE AB Objective: To determine possible etiologies of unsuccessful fluoroscopically guided tubal canalization, we studied the histology of tubal segments in cases of failed canalization for proximal tubal obstruction. Factors contributing to cases of unsuccessful fluoroscopically guided tubal canalization remain unclear. Design: Prospective. Setting: Reproductive Endocrinology Clinic. Materials: Twenty-seven cornual and/or isthmic tubal segments from 15 patients who underwent proximal tubal surgery after fluoroscopically guided tubal canalization were studied. Specimens were prepared with hemotoxylin-eosin and Masson trichrome stains. Results: Histologic examination of excised cornual and isthmic tubal segments revealed abnormalities in 93% of specimens. Obliterative fibrosis (61%), chronic salpingitis (57%), and salpingitis isthmica nodosa (42%) were the most commonly found histologic tubal abnormalities. One case of complete tubal occlusion and tubal schistosomiasis was also detected. Conclusions: These data suggest that cases of failed fluoroscopically guided tubal canalization may be secondary to severe intrinsic tubal disease and tubal occlusion and not to the technique. Fluoroscopically guided tubal canalization may provide a means of differentiating a functional obstruction amenable to conservative management from true occlusion requiring management by microsurgical techniques or in vitro fertilization. C1 TRIPLER ARMY MED CTR,DEPT PATHOL,ANAT PATHOL SERV,HONOLULU,HI 96859. RP LETTERIE, GS (reprint author), TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,REPROD ENDOCRINOL SERV,HONOLULU,HI 96859, USA. NR 17 TC 21 Z9 21 U1 0 U2 0 PU AMER SOC REPRODUCTIVE MEDICINE PI BIRMINGHAM PA 1209 MONTGOMERY HIGHWAY, BIRMINGHAM, AL 35216-2809 SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD NOV PY 1991 VL 56 IS 5 BP 831 EP 835 PG 5 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA GN926 UT WOS:A1991GN92600005 PM 1936314 ER PT J AU VONBREDOW, JD ADAMS, NL GROFF, WA VICK, JA AF VONBREDOW, JD ADAMS, NL GROFF, WA VICK, JA TI EFFECTIVENESS OF ORAL PYRIDOSTIGMINE PRETREATMENT AND CHOLINOLYTIC-OXIME THERAPY AGAINST SOMAN INTOXICATION IN NONHUMAN-PRIMATES SO FUNDAMENTAL AND APPLIED TOXICOLOGY LA English DT Article ID MYASTHENIA-GRAVIS; PROTECTION; CHOLINESTERASE; ANIMALS; ACETYLCHOLINESTERASE; ATROPINE RP VONBREDOW, JD (reprint author), USA,MED RES INST CHEM DEF,DIV PHARMACOL,ABERDEEN PROVING GROUND,MD 21010, USA. NR 27 TC 23 Z9 23 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0272-0590 J9 FUND APPL TOXICOL JI Fundam. Appl. Toxicol. PD NOV PY 1991 VL 17 IS 4 BP 761 EP 770 DI 10.1016/0272-0590(91)90183-5 PG 10 WC Toxicology SC Toxicology GA GN917 UT WOS:A1991GN91700010 PM 1778362 ER PT J AU PELUSO, F GOLDNER, F AF PELUSO, F GOLDNER, F TI FOLLOW-UP OF HOT BIOPSY FORCEPS TREATMENT OF DIMINUTIVE COLONIC POLYPS SO GASTROINTESTINAL ENDOSCOPY LA English DT Article ID CLINICAL-SIGNIFICANCE AB Although the hot biospy technique is widely used to treat diminutive colon polyps, there is concern over its efficacy and safety. Our study involved 39 patients undergoing routine colonoscopy in whom 62 diminutive polyps were found in the rectosigmoid. These lesions were treated with hot biopsy forceps in the standard manner. Flexible sigmoidoscopy was repeated 1 and 2 weeks later with the original treatment sites being identified. Eleven of the 62 sites (17%) revealed persistent viable polyp remnants, indicating incomplete treatment. In terms of safety, there were no clinical complications in this small study and most post-biopsy ulcers were healed by 2 weeks. This study shows that the hot biopsy technique may be unreliable in eradicating diminutive colon polyps. C1 BROOKE ARMY MED CTR,DEPT MED,SAN ANTONIO,TX. RP GOLDNER, F (reprint author), BROOKE ARMY MED CTR,DEPT MED,FT SAM HOUSTON,TX 78234, USA. NR 14 TC 43 Z9 44 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD NOV-DEC PY 1991 VL 37 IS 6 BP 604 EP 606 DI 10.1016/S0016-5107(91)70863-8 PG 3 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA GU027 UT WOS:A1991GU02700003 PM 1756918 ER PT J AU KADAKIA, SC COHAN, CF STARNES, EC AF KADAKIA, SC COHAN, CF STARNES, EC TI GUIDEWIRE-ASSISTED ESOPHAGEAL DILATION - RESPONSE SO GASTROINTESTINAL ENDOSCOPY LA English DT Letter RP KADAKIA, SC (reprint author), BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,SAN ANTONIO,TX, USA. NR 4 TC 1 Z9 1 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD NOV-DEC PY 1991 VL 37 IS 6 BP 651 EP 651 DI 10.1016/S0016-5107(91)70882-1 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA GU027 UT WOS:A1991GU02700022 ER PT J AU SMITH, AC AF SMITH, AC TI DIAGNOSIS AND INDICATIONS FOR SURGICAL-TREATMENT SO HAND CLINICS LA English DT Article RP SMITH, AC (reprint author), WALTER REED ARMY MED CTR,HAND SURG SECT,WASHINGTON,DC 20307, USA. NR 0 TC 20 Z9 20 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0749-0712 J9 HAND CLIN JI Hand Clin. PD NOV PY 1991 VL 7 IS 4 BP 635 EP 642 PG 8 WC Orthopedics SC Orthopedics GA GN487 UT WOS:A1991GN48700004 PM 1769986 ER PT J AU JOHANSON, WLR MOLTER, NC AF JOHANSON, WLR MOLTER, NC TI THE FUTURE PAVILION - CREATING A LEARNING ORGANIZATION SO HEART & LUNG LA English DT Editorial Material C1 USA,INST SURG RES,FT SAM HOUSTON,TX 78234. RP JOHANSON, WLR (reprint author), USA,INST SURG RES,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0147-9563 J9 HEART LUNG JI Heart Lung PD NOV PY 1991 VL 20 IS 6 BP A19 EP & PG 0 WC Cardiac & Cardiovascular Systems; Nursing; Respiratory System SC Cardiovascular System & Cardiology; Nursing; Respiratory System GA GU138 UT WOS:A1991GU13800001 ER PT J AU YEH, RT NAUMANN, DA MITTERMEIR, RT SCHLEMMER, RA GILMORE, WS SUMRALL, GE LEBARON, JT AF YEH, RT NAUMANN, DA MITTERMEIR, RT SCHLEMMER, RA GILMORE, WS SUMRALL, GE LEBARON, JT TI A COMMONSENSE MANAGEMENT MODEL SO IEEE SOFTWARE LA English DT Article C1 USA,COMMUN & ELECTR COMMAND,CTR SOFTWARE ENGN,DIV SOFTWARE TECHNOL,WASHINGTON,DC 20310. UNIV KLAGENFURT,INST COMP SCI,KLAGENFURT,AUSTRIA. SW TEXAS STATE UNIV,COMP SCI,SAN MARCOS,TX 78666. UNIV PITTSBURGH,PITTSBURGH,PA 15260. RP YEH, RT (reprint author), INT SOFTWARE SYST INC,9430 RES BLVD,ECHELON IV,SUITE 250,AUSTIN,TX 78759, USA. NR 9 TC 11 Z9 12 U1 0 U2 0 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 SN 0740-7459 J9 IEEE SOFTWARE JI IEEE Softw. PD NOV PY 1991 VL 8 IS 6 BP 23 EP 33 DI 10.1109/52.103574 PG 11 WC Computer Science, Software Engineering SC Computer Science GA GL899 UT WOS:A1991GL89900004 ER PT J AU BALLATO, A SMITS, JG AF BALLATO, A SMITS, JG TI NETWORK REPRESENTATION FOR PIEZOELECTRIC BIMORPHS SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Article ID PI-FET ACCELEROMETER; ELEMENTS; SYSTEM AB The exact electrical network representation for rectangular cantilevered bimorphs is developed from the constituent equations for the bimorph. These equations are written in terms of redefined extensive and intensive variables that makes it possible to write the bimorph matrix in numerical form. This numerical matrix is diagonalized to give the eigenvalues of bimorphs. The modal matrix is used to find the corresponding eigenstates. A physical interpretation of bimorph eigenstates is proposed. Two realizations of network representation are given for the admittance matrix. The eigenvalue matrix is inverted to give the impedance matrix. The bimorph matrix is also diagonalized with congruent transformations which give a transformation matrix which is upper triangular. This way two goals are met: to diagonalize the matrix, and to have a transformation matrix with the least number of elements, which can be used to create a network with the least number of elements. The network representation of the impedance matrix is given. The network representation is exact, it contains no approximations. The network permits faithful models of actuators using software CAD programs, such as Spice. RP BALLATO, A (reprint author), USA,COMMAND LAB,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. NR 37 TC 19 Z9 20 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD NOV PY 1991 VL 38 IS 6 BP 595 EP 602 DI 10.1109/58.108858 PG 8 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA GW460 UT WOS:A1991GW46000012 PM 18267624 ER PT J AU HARTMAN, AB POWELL, CJ SCHULTZ, CL OAKS, EV ECKELS, KH AF HARTMAN, AB POWELL, CJ SCHULTZ, CL OAKS, EV ECKELS, KH TI SMALL-ANIMAL MODEL TO MEASURE EFFICACY AND IMMUNOGENICITY OF SHIGELLA VACCINE STRAINS SO INFECTION AND IMMUNITY LA English DT Article ID ORAL IMMUNIZATION; RHESUS-MONKEYS; SONNEI VACCINE; LIVE VACCINE; FLEXNERI 2A; PROTECTION; CONSTRUCTION; INFECTION; CANDIDATE; ANTIGEN AB The development of a small-animal model to test the protective efficacy and immunogenicity of a vaccine strain against shigellosis would greatly facilitate the evaluation of potential vaccine candidates. In guinea pigs, the ability of shigellae to invade and multiply within the corneal epithelium, causing keratoconjunctivitis, closely mimics the invasion process in the intestinal epithelium (B. Sereny, Acta Microbiol. Acad. Sci. Hung. 4:367-376, 1957). The serum response of animals recovering from a Shigella keratoconjunctival infection was determined and found to be consistent with that shown by convalescent humans and primates. This model was used to test the efficacy of two vaccine candidates, and the immune response of the guinea pigs to the vaccine strains was examined. Both vaccine strains demonstrated significant protection against challenge by homologous virulent Shigella strains, and the results were comparable with results obtained in trials with monkeys. The guinea pig model also provides a rapid and inexpensive means of evaluating different immunization regimens as well as of testing other variables such as length of protection against disease. C1 WALTER REED ARMY MED CTR,DEPT ENTER INFECT,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. RP HARTMAN, AB (reprint author), WALTER REED ARMY MED CTR,DEPT BIOL RES,WASHINGTON,DC 20307, USA. NR 38 TC 53 Z9 57 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD NOV PY 1991 VL 59 IS 11 BP 4075 EP 4083 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA GM530 UT WOS:A1991GM53000033 PM 1937767 ER PT J AU LITTLEFIELD, TK RANDOLPH, PH AF LITTLEFIELD, TK RANDOLPH, PH TI PERT DURATION TIMES - MATHEMATICS OR MBO SO INTERFACES LA English DT Article AB We examine and compare the origins and mechanics of program evaluation and review technique (PERT) and management by objectives (MBO), reviewing the controversy concerning the mathematical validity of PERT activity duration estimates; the mathematics appear to be of little practical significance. It is the estimation process that is important, and this PERT estimation process is much like the objective development process of MBO. Definite similarities exist. PERT could be considered an extension of MBO. C1 TEXAS TECH UNIV,LUBBOCK,TX 79409. RP LITTLEFIELD, TK (reprint author), 65TH ENGINEER BATTALION,25TH INFANTRY DIV LIGHT,SCHOFIELD BARRACKS,HI 96857, USA. NR 19 TC 7 Z9 7 U1 1 U2 1 PU INST OPERATIONS RESEARCH MANAGEMENT SCIENCES PI LINTHICUM HTS PA 901 ELKRIDGE LANDING RD, STE 400, LINTHICUM HTS, MD 21090-2909 SN 0092-2102 J9 INTERFACES JI Interfaces PD NOV-DEC PY 1991 VL 21 IS 6 BP 92 EP 95 DI 10.1287/inte.21.6.92 PG 4 WC Management; Operations Research & Management Science SC Business & Economics; Operations Research & Management Science GA GW923 UT WOS:A1991GW92300009 ER PT J AU MCCANN, UD ROSSITER, EM KING, RJ AGRAS, WS AF MCCANN, UD ROSSITER, EM KING, RJ AGRAS, WS TI NONPURGING BULIMIA - A DISTINCT SUBTYPE OF BULIMIA-NERVOSA SO INTERNATIONAL JOURNAL OF EATING DISORDERS LA English DT Article ID BORDERLINE PERSONALITY-DISORDER; EATING DISORDERS; DEPRESSION; POPULATION AB Bulimics whose primary method of purgation was self-induced vomiting (purgers) were compared to bulimics who did not purge (nonpurgers), using standardized diagnostic instruments. Differences in eating patterns, demographic characteristics, past and present DSM-III-R diagnoses, mood and personality traits were found. Purgers were younger, more likely to be single, and binged more frequently than nonpurgers. More purgers had Major Depression, Panic Disorder, or past Anorexia Nervosa than did nonpurgers. Purgers scored higher on the narcissistic, masochistic (self-defeating), and borderline scales of the Personality Disorders Examination. In contrast, nonpurgers were more likely to be overweight and have history of substance abuse than purgers. These findings support the view that nonpurging bulimics constitute a distinct clinical group, and suggest that differences between purging and nonpurging bulimics may reflect differences in core pathology. C1 UNIFORMED SERV UNIV HLTH SCI,PSYCHIAT,BETHESDA,MD 20814. STANFORD UNIV,MED CTR,SCH MED,STANFORD,CA 94305. RP MCCANN, UD (reprint author), WALTER REED ARMY MED CTR,DEPT BEHAV BIOL,WASHINGTON,DC 20307, USA. OI Agras, Stewart/0000-0002-3116-8194 NR 27 TC 26 Z9 26 U1 0 U2 2 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0276-3478 J9 INT J EAT DISORDER JI Int. J. Eating Disord. PD NOV PY 1991 VL 10 IS 6 BP 679 EP 687 DI 10.1002/1098-108X(199111)10:6<679::AID-EAT2260100606>3.0.CO;2-C PG 9 WC Psychology, Clinical; Nutrition & Dietetics; Psychiatry; Psychology SC Psychology; Nutrition & Dietetics; Psychiatry GA GN749 UT WOS:A1991GN74900005 ER PT J AU LETTERIE, GS AF LETTERIE, GS TI SIMPLE MODIFICATION OF AN INTRAUTERINE MANIPULATOR SO INTERNATIONAL JOURNAL OF FERTILITY LA English DT Article AB A simple modification of an intrauterine manipulator is described replacing the single tooth of the upper arm with a rounded, atraumatic surface. C1 TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,REPROD ENDOCRINOL SERV,HONOLULU,HI 96859. RP LETTERIE, GS (reprint author), VIRGINIA MASON CLIN,REPROD ENDOCRINOL SERV,X8-OB,1100 9TH AVE,SEATTLE,WA 98111, USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU MEDICAL SCIENCE PUBLISHING INT INC PI PORT WASHINGTON PA 405 MAIN ST, PORT WASHINGTON, NY 11050 SN 0020-725X J9 INT J FERTIL PD NOV-DEC PY 1991 VL 36 IS 6 BP 358 EP 359 PG 2 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA GV114 UT WOS:A1991GV11400005 PM 1684960 ER PT J AU AMBRUS, JL HANEIWICH, S CHESKY, L MCFARLAND, P ENGLER, RJ AF AMBRUS, JL HANEIWICH, S CHESKY, L MCFARLAND, P ENGLER, RJ TI IMPROVED INVITRO ANTIGEN-SPECIFIC ANTIBODY-SYNTHESIS IN 2 PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY TAKING AN ORAL CYCLOOXYGENASE AND LIPOXYGENASE INHIBITOR (KETOPROFEN) SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Article DE B-CELL; COMMON VARIABLE IMMUNODEFICIENCY; PROLIFERATION; ANTIBODY PRODUCTION; 5-LIPOXYGENASE; KETOPROFEN ID CELL GROWTH-FACTOR; HUMAN-LYMPHOCYTES; T-CELLS; B-CELLS; VARIED IMMUNODEFICIENCY; INTERFERON-GAMMA; HYPOGAMMAGLOBULINEMIA; PROSTAGLANDIN-E2; INTERLEUKIN-4; LEUKOTRIENES AB In the process of performing a previously published study examining B cell function in 16 patients with common variable immunodeficiency (CVI)(J ALLERGY CLIN IMMUNOL 1991;87:1138-49), we noted improved in vitro antibody (Ab) synthesis in a patient, H.B., while he was taking a cyclooxygenase and lipoxygenase inhibitor, ketoprofen. Addition of ketoprofen in vitro to B cells from patients with CVI resulted in improved proliferation and differentiation in four of five additional patients with CVI studied. One patient, besides H. B., M. K. B., whose B cells secreted increased amounts of antigen (Ag)-specific Ab in response to in vitro ketoprofen, underwent a trial of oral ketoprofen. M. K. B., like H. B., demonstrated improved in vitro Ag-specific Ab production while she was taking oral ketoprofen. No increase in serum Ab levels was noted in either patient taking ketoprofen, but both patients remained infection free during the time of their ketoprofen trials (H. B., 9 months, and M. K. B., 36 months). No improvement in in vitro Ag-specific Ab synthesis was noted when H. B. and M. K. B. took oral cyclooxygenase inhibitors (naproxen or ibuprofen). Thus, additional study is warranted to examine the role of lipoxygenase products of arachidonic acid in the B cell dysfunction of CVI. C1 NIAID,BETHESDA,MD 20892. MED UNIV S CAROLINA,CHARLESTON,SC 29425. WALTER REED ARMY MED CTR,DIV ALLERGY & IMMUNIZAT,WASHINGTON,DC 20307. RP AMBRUS, JL (reprint author), WASHINGTON UNIV,JEWISH HOSP ST LOUIS,SCH MED,DIV RHEUMATOL,216 S KINGSHIGHWAY,ST LOUIS,MO 63110, USA. NR 34 TC 5 Z9 5 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0091-6749 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD NOV PY 1991 VL 88 IS 5 BP 775 EP 783 DI 10.1016/0091-6749(91)90185-Q PG 9 WC Allergy; Immunology SC Allergy; Immunology GA GQ452 UT WOS:A1991GQ45200013 PM 1955636 ER PT J AU RAFIEE, P LEFFLER, H BYRD, JC CASSELS, FJ BOEDEKER, EC KIM, YS AF RAFIEE, P LEFFLER, H BYRD, JC CASSELS, FJ BOEDEKER, EC KIM, YS TI A SIALOGLYCOPROTEIN COMPLEX LINKED TO THE MICROVILLUS CYTOSKELETON ACTS AS A RECEPTOR FOR PILUS (AF/R1) MEDIATED ADHESION OF ENTEROPATHOGENIC ESCHERICHIA-COLI (RDEC-1) IN RABBIT SMALL-INTESTINE SO JOURNAL OF CELL BIOLOGY LA English DT Article ID BORDER MYOSIN-I; TISSUE-CULTURE CELLS; BRUSH-BORDER; BACTERIAL ADHERENCE; EPITHELIAL-CELLS; PROTEIN; DIARRHEA; BINDING; STRAINS; PLASMID AB Escherichia coli strain RDEC-1 is an entero-adherent, diarrheagenic pathogen in rabbits that utilizes AF/R1 pili for initial (stage 1) adherence, but the host receptors for this adhesion are unknown. Here we demonstrate that RDEC-1 binds, via AF/R1 pili, to a specific rabbit ileal microvillus membrane glycoprotein receptor complex of subunits 130 and 140 kD. The binding involves sialic acid present on oligosaccharide moieties of the glycoprotein receptor. Furthermore, the microvillus membrane glycoprotein receptor complex appears to be associated with cytoskeletal components via brush border myosin 1. This newly described link between AF/R1 receptor and cytoskeletal components suggests that, in addition to this function in mucosal adherence, the pili may facilitate subsequent (second stage) close effacing attachment of RDEC-1 to the host epithelium by influencing cytoskeletal function. C1 UNIV CALIF SAN FRANCISCO,DEPT MED,SAN FRANCISCO,CA 94143. UNIV CALIF SAN FRANCISCO,DEPT PSYCHIAT,SAN FRANCISCO,CA 94143. WALTER REED ARMY MED CTR,DEPT GASTROENTEROL,WASHINGTON,DC 20307. RP RAFIEE, P (reprint author), VET ADM MED CTR,GASTROINTESTINAL RES LAB,SAN FRANCISCO,CA 94121, USA. OI Leffler, Hakon/0000-0003-4482-8945 FU NIADDK NIH HHS [AM17938] NR 49 TC 27 Z9 27 U1 0 U2 0 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 222 E 70TH STREET, NEW YORK, NY 10021 SN 0021-9525 J9 J CELL BIOL JI J. Cell Biol. PD NOV PY 1991 VL 115 IS 4 BP 1021 EP 1029 DI 10.1083/jcb.115.4.1021 PG 9 WC Cell Biology SC Cell Biology GA GP802 UT WOS:A1991GP80200012 PM 1683351 ER PT J AU DAY, PN TRUHLAR, DG AF DAY, PN TRUHLAR, DG TI THE CALCULATION OF HIGHLY EXCITED BOUND-STATE ENERGY-LEVELS FOR A TRIATOMIC MOLECULE BY USING 3-ARRANGEMENT BASIS-SETS AND CONTRACTED BASIS FUNCTIONS SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID DISCRETE VARIABLE REPRESENTATION; ROVIBRATIONAL STATES; VIBRATIONAL-STATES; FLOPPY MOLECULES; H-3+; SPECTRA; HCN/HNC; H2D+ AB The rovibrational energy levels of the nonrotating H3+ molecular ion have been calculated using a basis set defined in three-arrangement Jacobi coordinates. Energy levels corresponding to the A1' symmetry are reported up to 22 600 cm-1 above the potential energy minimum and are converged to within 1.8 cm-1, energy levels in the A2' symmetry are reported up to 28 800 cm-1 and are converged to within 0.7 cm-1, and energy levels in the E' symmetry are reported up to 24 300 cm-1 and are converged to within 1.8 cm-1. The maximum deviation of the reported results from the results of Carter and Meyer [J. Chem. Phys. 93, 8902 (1990)] is about 2 cm-1, and most of the results agree to within 1 cm-1. An advantage to our basis set is that it can represent the full D3h symmetry of this system, and thus the energy levels are assigned to the correct symmetry group unambiguously. In order to improve computational efficiency, contracted basis functions were formed using a successive diagonalization-truncation procedure. C1 UNIV MINNESOTA, ARMY HIGH PERFORMANCE COMP RES CTR, MINNEAPOLIS, MN 55455 USA. RP DAY, PN (reprint author), UNIV MINNESOTA, INST SUPERCOMP, DEPT CHEM, MINNEAPOLIS, MN 55455 USA. RI Truhlar, Donald/G-7076-2015 OI Truhlar, Donald/0000-0002-7742-7294 NR 33 TC 22 Z9 22 U1 0 U2 1 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD NOV 1 PY 1991 VL 95 IS 9 BP 6615 EP 6621 DI 10.1063/1.461531 PG 7 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA GL753 UT WOS:A1991GL75300044 ER PT J AU KURANE, I INNIS, BL NIMMANNITYA, S NISALAK, A MEAGER, A JANUS, J ENNIS, FA AF KURANE, I INNIS, BL NIMMANNITYA, S NISALAK, A MEAGER, A JANUS, J ENNIS, FA TI ACTIVATION OF LYMPHOCYTES-T IN DENGUE VIRUS-INFECTIONS - HIGH-LEVELS OF SOLUBLE INTERLEUKIN-2 RECEPTOR, SOLUBLE CD4, SOLUBLE CD8, INTERLEUKIN-2, AND INTERFERON-GAMMA IN SERA OF CHILDREN WITH DENGUE SO JOURNAL OF CLINICAL INVESTIGATION LA English DT Article DE DENGUE HEMORRHAGIC FEVER; DENGUE FEVER; LYMPHOKINES; SOLUBLE CELL SURFACE PROTEINS; T-CELL ACTIVATION ID MONONUCLEAR PHAGOCYTES; HEMORRHAGIC-FEVER; IMMUNE ACTIVATION; RECOMBINANT IL-2; CELL ACTIVATION; ANTIBODY; INVIVO; HIV; PATHOGENESIS; ENHANCEMENT AB It has been reported that the severe complication of dengue virus infection, dengue hemorrhagic fever (DHF) is much more commonly observed during secondary dengue virus infections than primary infections. In order to elucidate the role of T lymphocytes in the pathogenesis of DHF, we attempted to determine whether T lymphocytes are activated in vivo during dengue virus infections, by examining the levels of soluble IL-2 receptor (sIL-2R), soluble CD4 (sCD4), soluble CD8 (sCD8), interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) in the sera of 59 patients with DHF and 41 patients with dengue fever (DF). The levels of sIL-2R, sCD4, sCD8, IL-2, and IFN-gamma were significantly higher in the acute sera of patients with DHF than in the sera of healthy children (P < 0.001 for all markers). The acute sera of patients with DF contained higher levels of sIL-2R, sCD4, IL-2, and IFN-gamma than the sera of healthy children (P < 0.001 for sIL-2R, IL-2, and IFN-gamma; P < 0.05 for sCD4), but did not have elevated levels of sCD8. The levels of sIL-2R (P < 0.05), sCD4 (P < 0.001), and sCD8 (P < 0.001) were higher in DHF than in DF on days 3-4 after the onset of fever. The levels of IL-2 and IFN-gamma in patients with DHF were highest 1 d before defervescence. There were no significant differences in the levels of sIL-2R, sCD4, sCD8, IL-2, and IFN-gamma among grades 1, 2, and 3 of DHF. These results indicate (a) T lymphocytes are activated and produce IL-2 and IFN-gamma in vivo during DHF and DF, (b) CD4+ T lymphocytes are activated in DHF and DF, and the level of activation is higher in DHF than in DF, and (c) activation of CD8+ T lymphocytes is evident in DHF, but not in DF. C1 UNIV MASSACHUSETTS,MED CTR,DEPT MED,DIV INFECT DIS & IMMUNOL,WORCESTER,MA 01655. ARMED FORCES RES INST MED SCI,DEPT VIROL,BANGKOK 10400,THAILAND. CHILDRENS HOSP,BANGKOK 10400,THAILAND. NATL INST BIOL STAND & CONTROLS,DIV IMMUNOBIOL,HERTFORD EN6 3QG,HERTS,ENGLAND. FU NIAID NIH HHS [R01 AI30624]; PHS HHS [T32-A107272] NR 40 TC 206 Z9 212 U1 0 U2 1 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 222 E 70TH STREET, NEW YORK, NY 10021 SN 0021-9738 J9 J CLIN INVEST JI J. Clin. Invest. PD NOV PY 1991 VL 88 IS 5 BP 1473 EP 1480 DI 10.1172/JCI115457 PG 8 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA GN727 UT WOS:A1991GN72700007 PM 1939640 ER PT J AU BRENNER, DJ HOLLIS, DG MOSS, CW ENGLISH, CK HALL, GS VINCENT, J RADOSEVIC, J BIRKNESS, KA BIBB, WF QUINN, FD SWAMINATHAN, B WEAVER, RE REEVES, MW OCONNOR, SP HAYES, PS TENOVER, FC STEIGERWALT, AG PERKINS, BA DANESHVAR, MI HILL, BC WASHINGTON, JA WOODS, TC HUNTER, SB HADFIELD, TL AJELLO, GW KAUFMANN, AF WEAR, DJ WENGER, JD AF BRENNER, DJ HOLLIS, DG MOSS, CW ENGLISH, CK HALL, GS VINCENT, J RADOSEVIC, J BIRKNESS, KA BIBB, WF QUINN, FD SWAMINATHAN, B WEAVER, RE REEVES, MW OCONNOR, SP HAYES, PS TENOVER, FC STEIGERWALT, AG PERKINS, BA DANESHVAR, MI HILL, BC WASHINGTON, JA WOODS, TC HUNTER, SB HADFIELD, TL AJELLO, GW KAUFMANN, AF WEAR, DJ WENGER, JD TI PROPOSAL OF AFIPIA GEN-NOV, WITH AFIPIA-FELIS SP-NOV (FORMERLY THE CAT SCRATCH DISEASE BACILLUS), AFIPIA-CLEVELANDENSIS SP-NOV (FORMERLY THE CLEVELAND-CLINIC-FOUNDATION STRAIN), AFIPIA-BROOMEAE SP-NOV, AND 3 UNNAMED GENOSPECIES SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID MULTILOCUS ENZYME ELECTROPHORESIS; BACTERIA; SYSTEMATICS; INFECTION; AGENT; AIDS AB On the basis of phenotypic characterization and DNA relatedness determinations, the genus Afipia gen. nov., which contains six species, is described. The type species is Afipia felis sp. nov. (the cat scratch disease bacillus). Afipia clevelandensis sp. nov., Afipia broomeae sp. nov., and three unnamed Afipia genospecies are apparently not associated with cat-borne disease. All but one strain (Afipia genospecies 3) were isolated from human wound and respiratory sources. All Afipia species are gram-negative, oxidase-positive, nonfermentative rods in the alpha-2 subgroup of the class Proteobacteria. They are motile by means of a single flagellum. They grown on buffered charcoal-yeast extract agar and nutrient broth, but rarely on MacConkey agar, at 25 and 30-degrees-C. They are urease positive; but they are negative in reactions for hemolysis, indole production, H2S production (triple sugar iron agar), gelatin hydrolysis, esculin hydrolysis, and peptonization of litmus milk. They do not produce acid oxidatively from D-glucose, lactose, maltose, or sucrose. The major cell wall fatty acids are 11-methyloctadec-12-enoic (C(Br19:1)), cis-octadec-11-enoic (C18:1omega7c), and generally, 9,10-methylenehexadecanoate and 11,12-methyleneoctadecanoate; and there are only trace amounts of hydroxy acids. The guanine-plus-cytosine content is 61.5 to 69 mol%. A. felis is positive for nitrate reduction and is delayed positive for acid production from D-xylose, but it is catalase negative. A. clevelandensis is negative in all of these tests. A. broomeae is weakly positive for catalase production and acid production from D-xylose, but it is negative for nitrate reduction. C1 CTR DIS CONTROL,CTR INFECT DIS,RESP DIS BRANCH,ATLANTA,GA 30333. CTR DIS CONTROL,CTR INFECT DIS,BACTERIAL ZOONOSE ACTIV,ATLANTA,GA 30333. CTR DIS CONTROL,CTR INFECT DIS,DIV BACTERIAL & MYCOT DIS,ATLANTA,GA 30333. CTR DIS CONTROL,CTR INFECT DIS,HOSP INFECT PROGRAM,ATLANTA,GA 30333. ARMED FORCES INST PATHOL,DEPT INFECT & PARASIT DIS PATHOL,WASHINGTON,DC 20306. CLEVELAND CLIN FDN,DEPT MICROBIOL,CLEVELAND,OH 44195. TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859. INDIANA STATE BOARD HLTH,DIV DIS CONTROL LAB,INDIANAPOLIS,IN 46206. RP BRENNER, DJ (reprint author), CTR DIS CONTROL,CTR INFECT DIS,MENINGITIS & SPECIAL PATHOGENS BRANCH,ATLANTA,GA 30333, USA. NR 33 TC 172 Z9 173 U1 0 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD NOV PY 1991 VL 29 IS 11 BP 2450 EP 2460 PG 11 WC Microbiology SC Microbiology GA GK777 UT WOS:A1991GK77700016 PM 1774249 ER PT J AU BESSESEN, MT WANG, E ECHEVERRIA, P BLASER, MJ AF BESSESEN, MT WANG, E ECHEVERRIA, P BLASER, MJ TI ENTEROINVASIVE ESCHERICHIA-COLI - A CAUSE OF BACTEREMIA IN PATIENTS WITH AIDS SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Note ID ACQUIRED IMMUNODEFICIENCY SYNDROME; SHIGELLA; INFECTIONS; DIARRHEA; CHILDREN; ADULTS AB A strain of enteroinvasive Escherichia coli was isolated from the blood of a patient with advanced human immunodeficiency virus disease on repeated occasions, associated with severe diarrheal illness. The isolate was killed in vitro by control sera but not by sera collected from the patient before or after his bacterial illnesses. C1 DEPT VET AFFAIRS MED CTR,NASHVILLE,TN 37212. ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. UNIV COLORADO,SCH MED,DEPT MED,DENVER,CO 80262. VANDERBILT UNIV,DEPT MED,DIV INFECT DIS,NASHVILLE,TN 37235. RP BESSESEN, MT (reprint author), DENVER HLTH & HOSP,DIS CONTROL SERV,DENVER,CO 80204, USA. OI Bessesen, Mary/0000-0001-9305-1293 NR 22 TC 9 Z9 9 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD NOV PY 1991 VL 29 IS 11 BP 2675 EP 2677 PG 3 WC Microbiology SC Microbiology GA GK777 UT WOS:A1991GK77700067 PM 1774287 ER PT J AU RUBEL, GO AF RUBEL, GO TI DETERMINATION OF THE ACTIVITY OF 2-PROPANOL IN DIBUTYLPHTHALATE FROM SINGLE DROPLET ABSORPTION STUDIES SO JOURNAL OF COLLOID AND INTERFACE SCIENCE LA English DT Article ID AEROSOL DROPLETS; EVAPORATION RP RUBEL, GO (reprint author), USA,ARMAMENT MUNIT & CHEM COMMAND,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010, USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0021-9797 J9 J COLLOID INTERF SCI JI J. Colloid Interface Sci. PD NOV PY 1991 VL 147 IS 1 BP 46 EP 50 DI 10.1016/0021-9797(91)90132-R PG 5 WC Chemistry, Physical SC Chemistry GA GL371 UT WOS:A1991GL37100004 ER PT J AU GRABSKI, WJ SALASCHE, SJ AF GRABSKI, WJ SALASCHE, SJ TI MAPPING AND ORIENTING TISSUE DURING MOHS MICROGRAPHIC SURGERY - AN ALTERNATE APPROACH SO JOURNAL OF DERMATOLOGIC SURGERY AND ONCOLOGY LA English DT Article AB An alternate method for mapping and orienting tissue during Mohs micrographic surgery is described. This quick and simple technique eliminates the application of indelible dyes to the tissue margins. C1 BROOKE ARMY MED CTR,DERMATOL SERV,FT SAM HOUSTON,TX 78234. NR 4 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0148-0812 J9 J DERMATOL SURG ONC PD NOV PY 1991 VL 17 IS 11 BP 865 EP 868 PG 4 WC Oncology; Dermatology; Surgery SC Oncology; Dermatology; Surgery GA GQ063 UT WOS:A1991GQ06300004 PM 1757648 ER PT J AU LEVRI, EA PATRASCU, L KELCH, WJ AF LEVRI, EA PATRASCU, L KELCH, WJ TI PEROXIDE STABILITY IN SHORTENING - A USEFUL REFERENCE MATERIAL SO JOURNAL OF FOOD PROTECTION LA English DT Note AB Vegetable shortening was studied to determine if its peroxide value was stable enough after storage for one year to be used as a quality control reference material. Shortening samples were deliberately oxidized to contain low, medium, and high levels of peroxide and were then stored at 4-degrees-C for one year. Peroxide value was measured approximately every 14 d during this year. A total of 27 different determinations was made at each of the three different peroxide levels. The results indicated minimum variability within each level of peroxide during the year, and suggested that shortening would serve well as a reference material for quality control in the fats and oils industry and in food and nutrition research. C1 WALTER REED ARMY MED CTR,REG VET LAB,FT GEORGE G MEADE,MD 20755. NR 4 TC 1 Z9 1 U1 0 U2 0 PU INT ASSOC MILK FOOD ENVIRONMENTAL SANITARIANS, INC PI DES MOINES PA 6200 AURORA AVE SUITE 200W, DES MOINES, IA 50322-2838 SN 0362-028X J9 J FOOD PROTECT JI J. Food Prot. PD NOV PY 1991 VL 54 IS 11 BP 897 EP 899 PG 3 WC Biotechnology & Applied Microbiology; Food Science & Technology SC Biotechnology & Applied Microbiology; Food Science & Technology GA GQ448 UT WOS:A1991GQ44800014 ER PT J AU CALDERON, SN NEWMAN, AH TORTELLA, FC AF CALDERON, SN NEWMAN, AH TORTELLA, FC TI NOVEL 1-PHENYLCYCLOALKANECARBOXYLIC ACID-DERIVATIVES AS POTENTIAL ANTICONVULSANT AGENTS SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID DEXTROMETHORPHAN BINDING-SITES; GUINEA-PIG BRAIN; AFFINITY; CARBETAPENTANE; LIGANDS AB A series of analogues based on the anticonvulsant carbetapentane (1, 2-[2-(diethylamino)ethoxy]ethyl 1-phenyl-1-cyclopentylcarboxylate) was prepared as potential novel anticonvulsant drugs. Structure-activity relationships of analogues in which the ester function and cyclopentane moieties were modified have been investigated by evaluating their ability to prevent seizures in the rat maximal electroshock test. These compounds (11, ED50 = 16-mu-mol/kg; 12, ED50 = 86-mu-mol/kg, and 23, ED50 = 173-mu-mol/kg) were effective anticonvulsants. Compound 11, an alkyl ether derivative of 1, was more potent than the parent compound (ED50 = 48-mu-mol/kg) and also showed a 2-fold increase in potency compared to that of the prototypic anticonvulsant drug diphenylhydantoin. C1 WALTER REED ARMY MED CTR,DEPT APPL BIOCHEM,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,NEUROPHARMACOL BRANCH,WASHINGTON,DC 20307. NR 26 TC 10 Z9 10 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD NOV PY 1991 VL 34 IS 11 BP 3159 EP 3164 DI 10.1021/jm00115a002 PG 6 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA GQ615 UT WOS:A1991GQ61500002 PM 1956032 ER PT J AU HAMEKA, HF JENSEN, JO KAY, JG ROSENTHAL, CM ZIMMERMAN, GL AF HAMEKA, HF JENSEN, JO KAY, JG ROSENTHAL, CM ZIMMERMAN, GL TI THEORETICAL PREDICTION OF GEOMETRIES AND VIBRATIONAL INFRARED-SPECTRA OF RUTHENIUM OXIDE MOLECULES SO JOURNAL OF MOLECULAR SPECTROSCOPY LA English DT Article ID EFFECTIVE CORE POTENTIALS; TETROXIDE; MATRIX C1 USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. DREXEL UNIV,DEPT CHEM,PHILADELPHIA,PA 19104. BRYN MAWR COLL,DEPT CHEM,BRYN MAWR,PA 19010. RP HAMEKA, HF (reprint author), UNIV PENN,DEPT CHEM,PHILADELPHIA,PA 19104, USA. NR 11 TC 6 Z9 6 U1 1 U2 3 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0022-2852 J9 J MOL SPECTROSC JI J. Mol. Spectrosc. PD NOV PY 1991 VL 150 IS 1 BP 218 EP 221 DI 10.1016/0022-2852(91)90204-N PG 4 WC Physics, Atomic, Molecular & Chemical; Spectroscopy SC Physics; Spectroscopy GA GL971 UT WOS:A1991GL97100016 ER PT J AU MACALUSO, M DELZELL, E COLE, P WONGSRICHANALAI, C COWLES, S AF MACALUSO, M DELZELL, E COLE, P WONGSRICHANALAI, C COWLES, S TI VALIDITY OF A MORTALITY STUDY BASED ON A CORPORATE HEALTH SURVEILLANCE SYSTEM SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID CHEMICAL COMPANY; REFINERY; COHORT; EXPERIENCE; LEUKEMIA; WORKERS; CANCER AB We evaluated the Shell Health Surveillance System (HSS) by conducting two mortality studies at an oil refinery. Study A used the HSS to measure the mortality of active and retired workers during 1973 to 1982. Study B used additional information sources and followed up terminated employees. For subjects included in both studies, results were very similar. However, the mortality experience of terminees before 1973 (included only in study B) was different from that of study A subjects, reflecting differences in length of employment and time since hire. HSS-based studies provide valid measures of long-term effects of past exposures among retirees and of short-term effects of recent exposures among active employees. However, they cannot detect short-term effects of past exposures, and they have limited power for evaluating dose-response relationships. C1 US ARMY MED COMPONENT,ARMED FORCES RES INST MED SCI,DEPT IMMUNOL,BANGKOK,THAILAND. SHELL OIL CO,DEPT MED,HOUSTON,TX 77001. RP MACALUSO, M (reprint author), UNIV ALABAMA,SCH PUBL HLTH,DEPT EPIDEMIOL,221 TIDWELL HALL,UNIV STN,BIRMINGHAM,AL 35294, USA. RI Macaluso, Maurizio/J-2076-2015 OI Macaluso, Maurizio/0000-0002-2977-9690 NR 18 TC 1 Z9 1 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD NOV PY 1991 VL 33 IS 11 BP 1180 EP 1186 DI 10.1097/00043764-199111000-00017 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA GP567 UT WOS:A1991GP56700014 PM 1765862 ER PT J AU ROBIE, DK PEARL, RH AF ROBIE, DK PEARL, RH TI MODIFIED NISSEN FUNDOPLICATION - IMPROVED RESULTS IN HIGH-RISK CHILDREN SO JOURNAL OF PEDIATRIC SURGERY LA English DT Article; Proceedings Paper CT 22ND ANNUAL MEETING OF THE CANADIAN ASSOC OF PAEDIATRIC SURGEONS CY AUG 22-25, 1990 CL ST JOHNS, CANADA SP CANADIAN ASSOC PAEDIAT SURGEONS DE ANTIREFLUX OPERATION; GASTROESOPHAGEAL REFLUX ID GASTROESOPHAGEAL REFLUX; COMPLICATIONS; GASTROSTOMY; EXPERIENCE; SURGERY C1 WALTER REED ARMY MED CTR,DEPT SURG,PEDIAT SURG SERV,WASHINGTON,DC 20307. NR 16 TC 14 Z9 15 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0022-3468 J9 J PEDIATR SURG JI J. Pediatr. Surg. PD NOV PY 1991 VL 26 IS 11 BP 1268 EP 1272 DI 10.1016/0022-3468(91)90595-K PG 5 WC Pediatrics; Surgery SC Pediatrics; Surgery GA GP886 UT WOS:A1991GP88600002 PM 1812253 ER PT J AU CUENIN, MF SCHEIDT, MJ ONEAL, RB STRONG, SL PASHLEY, DH HORNER, JA VANDYKE, TE AF CUENIN, MF SCHEIDT, MJ ONEAL, RB STRONG, SL PASHLEY, DH HORNER, JA VANDYKE, TE TI AN INVIVO STUDY OF DENTIN SENSITIVITY - THE RELATION OF DENTIN SENSITIVITY AND THE PATENCY OF DENTIN TUBULES SO JOURNAL OF PERIODONTOLOGY LA English DT Article DE DENTIN; SENSITIVE ANATOMY; DENTIN; SENSITIVE THERAPY; DENTIN; SENSITIVE PHYSIOLOGY ID HYDRAULIC CONDUCTANCE; PREDENTIN COMPLEX; SMEAR LAYER; HYPERSENSITIVITY; PERMEABILITY; INVITRO; NERVES; TEETH; STIMULATION; THRESHOLDS AB DENTIN HYPERSENSITIVITY CAN BE A MAJOR problem for periodontal patients. The relationship between dentin hypersensitivity and the patency of dentin tubules in vivo has been established. Thirteen adult patients with teeth scheduled for extraction were selected and a stent fabricated to confirm location of the root surface being examined. Response to a constant air blast was recorded on a numeric pain rating scale (from 0 to 4) during the course of treatment. The tooth surface was initially treated with 0.5 molar EDTA (pH = 7.4), to remove the smear layer and expose tubules. The region was then treated with either a 3% monopotassium-monohydrogen oxalate solution or a 3% sodium chloride solution, both at pH = 2.4. Solutions were prepared to be indistinguishable to the examiner. Response to air was evaluated before and after EDTA treatment and after treatment with a desensitizing agent. The patient was anesthetized and the treated tooth extracted. Specimens were sectioned, critical point dried, sputter coated with gold, and examined under the scanning electron microscope. Photomicrographs were analyzed by computer assisted digital analysis to evaluate the degree of tubule occlusion. Statistical analysis by repeated measures ANOVA for univariate tests of hypothesis for within subject effects showed the sodium chloride solution was more effective in reducing dentin sensitivity than the potassium oxalate solution. Scanning electron micrographic analysis revealed a mean dentin tubule aperture size of 1.720 square mu-m following EDTA treatment alone, 0.564 square mu-m following potassium oxalate treatment, and 0.386 square mu-m following sodium chloride treatment. The data suggest that low pH NaCl solution may be an effective adjunct to the treatment of dentin hypersensitivity in post-periodontal surgery or recession patients. C1 MED COLL GEORGIA,SCH DENT,AUGUSTA,GA 30912. EASTMAN DENT CTR,ROCHESTER,NY 14620. RP CUENIN, MF (reprint author), USA,DENT ACTIV,FT GORDON,GA 30905, USA. FU NIDCR NIH HHS [DE 07908, DE 06436] NR 48 TC 37 Z9 39 U1 0 U2 0 PU AMER ACAD PERIODONTOLOGY PI CHICAGO PA 737 NORTH MICHIGAN AVENUE, SUITE 800, CHICAGO, IL 60611-2690 SN 0022-3492 J9 J PERIODONTOL JI J. Periodont. PD NOV PY 1991 VL 62 IS 11 BP 668 EP 673 PG 6 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA GR297 UT WOS:A1991GR29700005 PM 1753319 ER PT J AU BROOMFIELD, CA MAXWELL, DM SOLANA, RP CASTRO, CA FINGER, AV LENZ, DE AF BROOMFIELD, CA MAXWELL, DM SOLANA, RP CASTRO, CA FINGER, AV LENZ, DE TI PROTECTION BY BUTYRYLCHOLINESTERASE AGAINST ORGANOPHOSPHORUS POISONING IN NONHUMAN-PRIMATES SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS LA English DT Article ID ACETYLCHOLINESTERASE PROPHYLAXIS; SOMAN; TOXICITY; MOUSE AB Butyrylcholinesterase (BuChE) was examined as an in vivo exogenous scavenger for highly toxic organophosphorus (OP) poisons. Protection studies with equine BuChE were carried out in rhesus monkeys trained to perform a Serial Probe Recognition task. The pharmacokinetics of equine BuChE administered i.v. in rhesus monkeys revealed an elimination T1/2 of approximately 620 hr. Animals given 503 nmol of BuChE i.v. and then challenged with 220 to 260 nmol of soman (two LD50; a lethal dose in untreated animals) all survived with no clinical signs of OP poisoning. Serial Probe Recognition performance was depressed after enzyme administration and at 1 hr postsoman. However, all monkeys performed the task at base-line levels at 8 hr after soman and throughout the remainder of the experimental period. Two different monkeys each were given two doses of sarin, 183 nmol/dose (one LD50) after 460 nmol of BuChE. No signs were observed. A third group of monkeys given 253 or 340 nmol (three and four LD50, respectively) of soman after 460 nmol of BuChE required 1 mg/kg of atropine i.v. 10 min postsoman, but recovered completely within 24 hr. Our results indicate that BuChE has the required properties to function as a biological scavenger to protect against the pharmacological and behavioral toxicity of OP poisons. C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 27 TC 132 Z9 135 U1 0 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-3565 J9 J PHARMACOL EXP THER JI J. Pharmacol. Exp. Ther. PD NOV PY 1991 VL 259 IS 2 BP 633 EP 638 PG 6 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA GP823 UT WOS:A1991GP82300024 PM 1941611 ER PT J AU WALKER, CW AF WALKER, CW TI PULSE POWER CHARACTERISTICS OF POLY(3-METHYLTHIOPHENE) CATHODES IN LI(SO2)3ALCL4 ELECTROLYTE SO JOURNAL OF POWER SOURCES LA English DT Article ID CONDUCTIVITY AB Thin, electrically conducting poly(3-methylthiophene) (PMT) films were formed electrochemically and used as cathodes in rechargeable lithium/sulfur dioxide cells. The pulse power capabilities of 1.4-mu-m thick PMT films were studied in Li(SO2)3AlCl4 electrolyte. Current densities of 56 mA cm-2 (800 W cm-3) were measured 0.5 s after applying a 1.46 V potential step from open circuit to 2.0 V. Multiple four second current pulses of 25 mA cm-2 (approximately 500 W cm-3) with one second rest periods between pulses were reproducible over many cycles. RP WALKER, CW (reprint author), USA,DIV POWER SOURCES,ELECTR TECHNOL & DEVICES LAB,LABCOM,SCLET PR,FT MONMOUTH,NJ 07703, USA. NR 11 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD NOV PY 1991 VL 36 IS 2 BP 175 EP 183 DI 10.1016/0378-7753(91)80013-N PG 9 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA GH160 UT WOS:A1991GH16000006 ER PT J AU ADRIAN, ED KRANTZ, WA IVANHOE, JR EDGE, MJ AF ADRIAN, ED KRANTZ, WA IVANHOE, JR EDGE, MJ TI AN IMPROVED INDEX FOR THE WAXED STAGE OF AN IMPLANT-RETAINED FRAMEWORK SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article AB A method for making an improved index for the waxed stage of Branemark implant-retained frameworks is described. The index improves visibility of the tooth and abutment cylinder relationship permitting the optimization of framework dimensions and contour. C1 USA,DENTAC,REMOVABLE PROSTHODONT SERV,FT GORDON,GA 30905. USA,DENTAC,PROSTHODONT RESIDENCY PROGRAM,FT GORDON,GA 30905. EMORY UNIV,SCH POSTGRAD DENT,DEPT PROSTHODONT,ATLANTA,GA 30322. NR 1 TC 1 Z9 1 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD NOV PY 1991 VL 66 IS 5 BP 665 EP 669 DI 10.1016/0022-3913(91)90450-B PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA GM805 UT WOS:A1991GM80500018 PM 1805006 ER PT J AU LETTERIE, GS VAUSS, N AF LETTERIE, GS VAUSS, N TI MULLERIAN TRACT ABNORMALITIES AND ASSOCIATED AUDITORY DEFECTS SO JOURNAL OF REPRODUCTIVE MEDICINE LA English DT Article ID MIDDLE-EAR ANOMALIES; FAMILY AB Fifteen women with mullerian defects and a control population of 15 with normal mullerian systems underwent dynamic audiometric testing. The rate of auditory defects in women with mullerian abnormalities (33%) was significantly higher (P < .05) than in the control population (0%). Those patients manifested mild, moderate and severe sensorineural defects in the high-frequency range. The defects were not accounted for by age or occupation and were associated with renal agenesis in 60% of the cases. One patient with normal audiometric testing and a septate uterus had a family history significant for an identical twin sister with unilateral renal agenesis, ipsilateral congenital deafness and an unevaluated mullerian tract. The results of the study suggest that a spectrum of auditory changes may exist in association with mullerian defects, ranging from previously described congenital deafness to more subtle hearing defects not clinically evident. C1 TRIPLER ARMY MED CTR,DEPT OTOLARYNGOL,AUDIOL SERV,HONOLULU,HI 96859. RP LETTERIE, GS (reprint author), TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,REPROD ENDOCRINOL SERV,HONOLULU,HI 96859, USA. NR 13 TC 14 Z9 15 U1 0 U2 0 PU SCI PRINTERS & PUBL INC PI ST LOUIS PA P.O. DRAWER 12425 8342 OLIVE BLVD, ST LOUIS, MO 63132 SN 0024-7758 J9 J REPROD MED JI J. Reprod. Med. PD NOV PY 1991 VL 36 IS 11 BP 765 EP 768 PG 4 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA GR584 UT WOS:A1991GR58400001 PM 1765952 ER PT J AU GILLETT, MC AF GILLETT, MC TI THE SANITARIANS - A HISTORY OF AMERICAN PUBLIC-HEALTH - DUFFY,J SO JOURNAL OF SOUTHERN HISTORY LA English DT Book Review RP GILLETT, MC (reprint author), USA,CTR MIL HIST,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOUTHERN HISTORICAL ASSN PI ATHENS PA UNIV GEORGIA HISTORY DEPT, ATHENS, GA 30602 SN 0022-4642 J9 J SOUTHERN HIST JI J. South. Hist. PD NOV PY 1991 VL 57 IS 4 BP 780 EP 781 DI 10.2307/2210655 PG 2 WC History SC History GA GR850 UT WOS:A1991GR85000061 ER PT J AU ROSENMEIER, GJ KEELING, JH GRABSKI, WJ MCCOLLOUGH, ML SOLIVAN, GA AF ROSENMEIER, GJ KEELING, JH GRABSKI, WJ MCCOLLOUGH, ML SOLIVAN, GA TI LATENT CUTANEOUS MYCOBACTERIUM-FORTUITUM INFECTION IN A HEALTHY MAN SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID DIAGNOSIS; ORGANISMS; PATHOGEN; DISEASE; COMPLEX AB Mycobacterium fortuitum infection developed in the foot of an otherwise healthy man 15 years after traumatic implantation of a foreign body. C1 DARNALL ARMY COMMUNITY HOSP,DERMATOL SERV,KILLEEN,TX. RP ROSENMEIER, GJ (reprint author), BROOKE ARMY MED CTR,DERMATOL SERV,FT SAM HOUSTON,TX 78234, USA. NR 41 TC 9 Z9 9 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD NOV PY 1991 VL 25 IS 5 BP 898 EP 902 DI 10.1016/S0190-9622(08)80362-3 PN 2 PG 5 WC Dermatology SC Dermatology GA GN038 UT WOS:A1991GN03800006 PM 1684802 ER PT J AU VUKELJA, SJ BONNER, MW MCCOLLOUGH, M COBB, PW GAULE, DA FANUCCHI, PJ KEELING, JH AF VUKELJA, SJ BONNER, MW MCCOLLOUGH, M COBB, PW GAULE, DA FANUCCHI, PJ KEELING, JH TI UNUSUAL SERPENTINE HYPERPIGMENTATION ASSOCIATED WITH 5-FLUOROURACIL - CASE-REPORT AND REVIEW OF CUTANEOUS MANIFESTATIONS ASSOCIATED WITH SYSTEMIC 5-FLUOROURACIL SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID PLANTAR ERYTHRODYSESTHESIA SYNDROME; SEBORRHEIC DERMATITIS; INFUSION; THERAPY; FLUOROURACIL; 5-FU AB A variety of cutaneous reactions have been reported with the use of systemic 5-fluorouracil. Our patient had serpentine hyperpigmented streaks appearing 5 days after bolus infusion of 5-fluorouracil. The patient also had other skin eruptions, that is, inflammation of actinic keratoses and folliculitis limited to the forehead; these reactions have been reported previously with 5-fluorouracil medication. We report this case and review the literature on skin manifestations associated with 5-fluorouracil therapy. C1 BROOKE ARMY MED CTR,DEPT MED,DERMATOL SERV,FT SAM HOUSTON,TX 78234. RP VUKELJA, SJ (reprint author), BROOKE ARMY MED CTR,DEPT MED,HEMATOL ONCOL SERV,FT SAM HOUSTON,TX 78234, USA. NR 27 TC 22 Z9 22 U1 1 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD NOV PY 1991 VL 25 IS 5 BP 905 EP 908 DI 10.1016/0190-9622(91)70280-F PN 2 PG 4 WC Dermatology SC Dermatology GA GN038 UT WOS:A1991GN03800008 PM 1837033 ER PT J AU SAU, P SOLIVAN, G JOHNSON, FB AF SAU, P SOLIVAN, G JOHNSON, FB TI CUTANEOUS REACTION FROM A BROKEN THERMOMETER SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID METALLIC MERCURY; GRANULOMA AB A cutaneous and soft tissue reaction that resulted from a broken thermometer inside the mouth of a 10-year-old boy is described. Metallic mercury globules and glass pieces were identified in the excised tissue. On histologic examination, a zone of necrosis, polymorphonuclear leukocytes, macrophages, and multinucleated giant cells surrounded metallic mercury that appeared as dark opaque globules. Dense fibrosis and reactive lymphoid hyperplasia were also noted in the dermis and deeper tissues. The gold lysis test, scanning electron microscopy, and energy-dispersive x-ray analysis confirmed the presence of mercury in the tissue. A literature review on cutaneous mercury granuloma illustrates its unpredictable course. The cutaneous reaction may remain localized, but some cases are associated with an elevated mercury level in blood and urine, pulmonary embolism, mercury poisoning, and even with fatal outcome. Various manifestations of mercury poisoning and guidelines for the management of cutaneous mercury granuloma are discussed. C1 ARMED FORCES INST PATHOL,DEPT CHEM PATHOL,WASHINGTON,DC 20306. RP SAU, P (reprint author), WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307, USA. NR 16 TC 23 Z9 23 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD NOV PY 1991 VL 25 IS 5 BP 915 EP 919 DI 10.1016/0190-9622(91)70283-8 PN 2 PG 5 WC Dermatology SC Dermatology GA GN038 UT WOS:A1991GN03800011 PM 1761770 ER PT J AU SMITH, KJ SKELTON, HG GIBLIN, WL JAMES, WD AF SMITH, KJ SKELTON, HG GIBLIN, WL JAMES, WD TI CUTANEOUS LESIONS OF HEMOPHAGOCYTIC SYNDROME IN A PATIENT WITH T-CELL LYMPHOMA AND ACTIVE EPSTEIN-BARR INFECTION SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID CYTOPHAGIC HISTIOCYTIC PANNICULITIS; MALIGNANT HISTIOCYTOSIS; SYSTEMIC HISTIOCYTOSIS; HEMORRHAGIC DIATHESIS; LEUKEMIA; MARKERS AB The hemophagocytic syndrome (HPS) was first described in immune-compromised patients with secondary viral infections. Immunodeficiency has not always been diagnosed before the onset of HPS, but most patients who develop HPS have known immune deficits. HPS has also been reported in association with lymphoreticular malignancies. In HPS the most prominent histologic change is phagocytosis of red blood cells and other bone marrow-derived elements by cytologically benign histiocytes. Considerable confusion exists about the similarities and differences between HPS and other conditions in which hemophagocytosis may occur, for example, histiocytic medullary reticulosis, T-gamma lymphoma, malignant histiocytic lymphoma, and cytophagic histiocytic panniculitis. We report a patient with HPS and cutaneous lesions of cytophagic histiocytic panniculitis who also had an active Epstein-Barr virus infection, and a CD8+ T-cell lymphoma. C1 ARMED FORCES INST PATHOL,DEPT DERMATOPATHOL,WASHINGTON,DC 20306. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT DERMATOL,WASHINGTON,DC 20307. DERMATOL SERV,FT DIX,NJ. NR 27 TC 43 Z9 43 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD NOV PY 1991 VL 25 IS 5 BP 919 EP 924 DI 10.1016/0190-9622(91)70284-9 PN 2 PG 6 WC Dermatology SC Dermatology GA GN038 UT WOS:A1991GN03800012 PM 1662240 ER PT J AU CONNON, WH AF CONNON, WH TI COMMENTS ON KURTOSIS OF MILITARY VEHICLE VIBRATION DATA SO JOURNAL OF THE IES LA English DT Article AB Road vibration tests were recently conducted on a series of shelters on dolly sets and on a series of prototype trucks at the U.S. Army Combat Systems Test Activity (USACSTA) at Aberdeen Proving Ground. Data from histogram or amplitude distribution tables were plotted in the normal probability domain to provide a graphic representation. When examining these probability plot data, a divergence of the actual distribution from the normal distribution at the tails was noticed. Of the 104 trials compared, the normal distribution was exceeded by 30 trials at the 90 percent level, 87 trials at the 99 percent level, and 88 trials at the 99.9 percent level. This indicates that the actual measured values at the extreme ends of the distribution (beyond the 90 percent occurrence levels) are larger in magnitude (acceleration) than would be predicted by the assumption of a normal distribution. This same trend was noticed during examination of the kurtosis values for the same data sets. The values generally exceeded a value of three, which is the expected value for a Gaussian distribution. Because the kurtosis is largely affected by data values far from the mean, a correlation between the normalized 99.9 percent values and the normalized kurtosis values was tried. A linear regression line was fit through the data, which produced a correlation of approximately 0.82. Although no formal effort has been put forth to catalog kurtosis measurements from military vehicles, it has generally been observed that the kurtosis values obtained from operation over our test courses is greater than three, indicating that the tails of a vibration distribution from operation over severe terrain are further from the mean (larger amplitude) than would be predicted from a normal distribution. If the kurtosis of the laboratory test distribution is less than that of the field distribution, the extreme values seen in the field environment will not be duplicated in the lab. The addition of conservatism during the schedule development process should be enough to overcome this difference; however, dome effort should be made to develop a "bi-domain" (frequency and time domain amplitude) control system so that the amplitude distribution of the lab test will more closely match that of the field data from which the schedule was derived. RP CONNON, WH (reprint author), USA,COMBAT SYST TEST ACTIV,ABERDEEN PROVING GROUND,MD 21010, USA. NR 0 TC 5 Z9 6 U1 0 U2 0 PU INST ENVIRONMENTAL SCI PI MT PROSPECT PA 940 E NORTHWEST HIGHWAY, MT PROSPECT, IL 60056 SN 1052-2883 J9 J IES JI J. IES PD NOV-DEC PY 1991 VL 34 IS 6 BP 38 EP 41 PG 4 WC Engineering, Environmental; Environmental Sciences; Instruments & Instrumentation SC Engineering; Environmental Sciences & Ecology; Instruments & Instrumentation GA GW574 UT WOS:A1991GW57400005 ER PT J AU CHOI, CS SCHROEDER, J LEE, YT FRANKEL, J COX, JF AF CHOI, CS SCHROEDER, J LEE, YT FRANKEL, J COX, JF TI THERMODYNAMIC PROPERTIES OF AQUEOUS-SOLUTIONS OF AMMONIUM-NITRATE SALTS SO JOURNAL OF THERMAL ANALYSIS LA English DT Article ID SCATTERING; SYSTEMS; WATER AB We present Differential Scanning Calorimetry (DSC) results on Hydroxyl Ammonium Nitrate (HAN) solutions and Triethanol Ammonium Nitrate (TEAN) solutions with varying concentrations. These results are used to generate phase diagrams of these solutions. The results of the melting points of these liquids are compared with the theoretical calculations of the depression of melting points. The melting temperatures of the HAN solutions at some specified concentration range are predicted rather well using the two electrolyte assumption. The phase diagram of the TEAN solutions explains an instability with respect to phase separation of this liquid. C1 RENSSELAER POLYTECH INST,DEPT PHYS,TROY,NY 12180. USA,RES & DEV ENGN CTR AMCCOM,WATERVLIET ARSENAL,WATERVLIET,NY 12189. NR 16 TC 1 Z9 1 U1 1 U2 4 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0368-4466 J9 J THERM ANAL JI J. Therm. Anal. PD NOV-DEC PY 1991 VL 37 IS 11-12 BP 2525 EP 2539 DI 10.1007/BF01912798 PG 15 WC Thermodynamics; Chemistry, Analytical; Chemistry, Physical SC Thermodynamics; Chemistry GA HM684 UT WOS:A1991HM68400006 ER PT J AU HUBBARD, GB LANGLINAIS, PC SHIMAZU, T OKERBERG, CV MASON, AD PRUITT, BA AF HUBBARD, GB LANGLINAIS, PC SHIMAZU, T OKERBERG, CV MASON, AD PRUITT, BA TI THE MORPHOLOGY OF SMOKE-INHALATION INJURY IN SHEEP SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article ID PULMONARY COMPLICATIONS; PATHO-PHYSIOLOGY; BURN PATIENTS; MODEL; FIRES AB Pulmonary injury resulting from inhalation of chemical and particulate products of incomplete combustion is one of the principal determinants of mortality following burn injury. In this study, the histopathology of inhalation injury was examined in sheep. Mild, moderate, or severe smoke injury was produced in anesthetized sheep by insufflation with various doses of ambient temperature smoke, generated by burning polyethylene, wood pulp, and nonwoven cellulose pads. A total of 64 sheep were exposed and evaluated at times ranging from 15 minutes to 4 weeks after exposure. Morphologic changes in the lungs were studied using light microscopy and both transmission and scanning electron microscopy. The primary, dose-responsive injury observed was acute cell membrane damage in the trachea and bronchi leading to edema, progressive necrotic tracheobronchitis with pseudomembrane formation, and airway obstruction. These inflammatory and occlusive effects were followed by congestion, alveolar space edema, atelectasis, and bronchopneumonia. Morphologic changes occurring in the alveolar epithelium following high smoke dosage included intracellular edema in type-I cells, changes in the membrane-bound vacuoles of type-II cells, and septal thickening caused by interstitial edema. No capillary endothelial changes were observed. C1 USA,LIB BRANCH,FT SAM HOUSTON,TX 78234. SW FDN BIOMED RES,SAN ANTONIO,TX 78284. OSAKA UNIV,SCH MED,DEPT TRAUMATOL,OSAKA,JAPAN. NR 28 TC 63 Z9 64 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD NOV PY 1991 VL 31 IS 11 BP 1477 EP 1486 DI 10.1097/00005373-199111000-00003 PG 10 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA GR601 UT WOS:A1991GR60100003 PM 1942167 ER PT J AU LEPAGE, PA VILLAVICENCIO, JL GOMEZ, ER SHERIDAN, MN RICH, NM AF LEPAGE, PA VILLAVICENCIO, JL GOMEZ, ER SHERIDAN, MN RICH, NM TI THE VALVULAR ANATOMY OF THE ILIAC VENOUS SYSTEM AND ITS CLINICAL IMPLICATIONS SO JOURNAL OF VASCULAR SURGERY LA English DT Article AB Clinical and phlebographic evidence exists that correlates the presence of varices of the vulva, posterior thigh, and the pelvic congestion syndrome with insufficiency of the internal iliac venous system (pelvic dumping syndrome). Information in the modern medical literature regarding the valvular anatomy of the internal iliac veins and its tributaries is limited. We dissected 82 iliac venous system specimens in 42 human cadavers (29 men, 13 women) to gain information on the relationship between the disease described and the anatomy of the region. Each specimen contained common, external, and internal iliac veins, including the tributaries of the latter. We recorded the anatomic variations of the internal iliac vein trunk and the location of valves in the complete iliac venous system, including 485 tributaries of the internal iliac veins. Five specimens of internal iliac vein had calcified thrombosis or were extensively involved with pelvic carcinoma and were not suitable for valve study, which left 79 specimens for analysis. The internal iliac vein drained into the external iliac venous system by means of a single trunk in 73% of the specimens and by two well-formed and separated trunks in 27% of the specimens. In one specimen (1.2%) the internal iliac vein drained directly into the inferior vena cava (parallel internal and external iliac veins). One specimen had a well-developed valve in the common iliac vein (1.2%). The external iliac vein had one valve in 26.2% of the specimens. This vein had three times as many valves on the right side as in the left (39.6% vs 14.6%: p = 0.0106). The internal iliac vein had valves present in 10.1% of its main trunks and in 9.1% of the 485 tributaries dissected. This is the first time that well-developed valves have been demonstrated in the internal iliac vein and their location described in a series of human cadaver dissections. The scarcity of valves in the pelvic veins, however, led us to consider that varicose veins in the vulva or elsewhere develop not only because of valvular insufficiency but also because of genetic structural venous wall anomalies as well as hormonal and hemodynamic factors present during pregnancy. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,4301 JONES BRIDGE RD,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,GEN & VASC SURG SERV,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT ANAT,BETHESDA,MD 20814. NR 26 TC 33 Z9 36 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD NOV PY 1991 VL 14 IS 5 BP 678 EP 683 PG 6 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA GP330 UT WOS:A1991GP33000016 PM 1942378 ER PT J AU STAMBAUGH, LTCKI AF STAMBAUGH, LTCKI TI UPPER LID BLEPHAROPLASTY - SKIN FLAP VS PINCH SO LARYNGOSCOPE LA English DT Article RP STAMBAUGH, LTCKI (reprint author), BROOKE ARMY MED CTR,DEPT SURG,OTOLARYNGOL SERV,FT SAM HOUSTON,TX 78234, USA. NR 8 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0023-852X J9 LARYNGOSCOPE JI Laryngoscope PD NOV PY 1991 VL 101 IS 11 BP 1233 EP 1237 PG 5 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA HC361 UT WOS:A1991HC36100014 ER PT J AU SMITH, B AF SMITH, B TI VACUUM ELECTRONICS IN TOMORROWS STRATEGIC ARMY SO MICROWAVE JOURNAL LA English DT Article RP SMITH, B (reprint author), USA,COMMAND LAB,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. NR 4 TC 2 Z9 2 U1 0 U2 0 PU HORIZON HOUSE-MICROWAVE PI NORWOOD PA 685 CANTON ST, NORWOOD, MA 02062 SN 0192-6225 J9 MICROWAVE J JI Microw. J. PD NOV PY 1991 VL 34 IS 11 BP 60 EP & PG 0 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA GR687 UT WOS:A1991GR68700002 ER PT J AU WHITE, LS DELACRUZ, J AF WHITE, LS DELACRUZ, J TI A MODEL PROGRAM - STRESS MANAGEMENT UNIT - A CLINIC RUN BY ARMY NURSES SO MILITARY MEDICINE LA English DT Article AB People suffering from stress and stress-related disorders are a great challenge to our already depleted military health care system. Early identification and separation of soldiers not able to adjust, immediate intervention for temporarily stressed soldiers, and stress management for dependents and retirees help decrease visits to military hospitals and clinics. Immediate intervention for salvageable soldiers also helps improve work performance and productivity. A Stress Management Unit has been open for two years at Brooke Army Medical Center (BAMC), Texas. This article identifies the need for stress management clinics in the military and briefly describes the nurse-run program at BAMC. RP WHITE, LS (reprint author), BROOKE ARMY MED CTR,STRESS MANAGEMENT UNIT,CHAMBERS PAVIL,FT SAM HOUSTON,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 1991 VL 156 IS 11 BP 599 EP 602 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA GP395 UT WOS:A1991GP39500012 PM 1771007 ER PT J AU MEADE, PG RUDOLPH, C HUANG, YC AF MEADE, PG RUDOLPH, C HUANG, YC TI ANURIA FOLLOWING REDUCTION OF A GIANT OMPHALOCELE IN A NEONATE - AN UNUSUAL COMPLICATION SO MILITARY MEDICINE LA English DT Article AB Giant omphalocoele in the neonate is a challenging surgical emergency and requires individualized approaches to operative repair. Post-operative complications and associated congenital anomalies still continue to exert a high morbidity and mortality in spite of intensive and improved post-operative care. This case report describes an unusual mechanism which produced anuria in a neonate immediately after operative reduction of a giant omphalocoele. In retrospect, this complication was related to the unique anatomy of the neonate and the type of closure utilized. RP MEADE, PG (reprint author), TRIPLER ARMY MED CTR,DEPT SURG,HONOLULU,HI 96859, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 1991 VL 156 IS 11 BP 629 EP 630 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA GP395 UT WOS:A1991GP39500018 PM 1771013 ER PT J AU CHAPMAN, WHH BARCIA, PJ AF CHAPMAN, WHH BARCIA, PJ TI FEMORAL HERNIA IN CHILDREN - AN INFREQUENT PROBLEM REVISITED SO MILITARY MEDICINE LA English DT Article AB Femoral hernias are of very rare occurrence at any age, but are exceedingly rare in the pediatric population. A 10-year survey, 1979-1989, of our experience with pediatric hernias produced a total of 1,134 inguinal hernias and 6 femoral hernias, supporting an incidence of 0.5% for femoral hernias in our population. The correct diagnosis was made in only two cases preoperatively. These two patients had undergone inguinal herniorrhaphies less than 6 months prior to presenting with recurrent groin masses. Femoral hernias were most frequently misdiagnosed as inguinal hernias. Inclusion of this entity in the differential diagnosis of groin masses, an accurate preoperative physical exam, and a careful surgical exploration will allow one to make the correct diagnosis and prevent unnecessary reoperations. In addition, early recurrence of a groin mass after inguinal exploration and herniorrhaphy should make one suspicious of a femoral hernia. At surgery, our recommendations include a simple infra-inguinal exploration medial to the femoral vessels when an inguinal hernia is unexpectedly not found at groin exploration and a Cooper's ligament repair when a femoral hernia is encountered. All six cases in our review were repaired with Cooper's ligament repair without complication. RP CHAPMAN, WHH (reprint author), TRIPLER ARMY MED CTR,DEPT SURG,HONOLULU,HI 96859, USA. NR 0 TC 13 Z9 13 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 1991 VL 156 IS 11 BP 631 EP 633 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA GP395 UT WOS:A1991GP39500019 PM 1771014 ER PT J AU FARR, WD AF FARR, WD TI UNITED-STATES-ARMY SPECIAL FORCES MILITARY MEDICAL HISTORY SO MILITARY MEDICINE LA English DT Letter RP FARR, WD (reprint author), USA,BROOKS AFB,TX, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 1991 VL 156 IS 11 BP A7 EP A7 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA GP395 UT WOS:A1991GP39500006 ER PT J AU YAMASAKI, R NASHOLDS, W SCHNEIDER, H APICELLA, MA AF YAMASAKI, R NASHOLDS, W SCHNEIDER, H APICELLA, MA TI EPITOPE EXPRESSION AND PARTIAL STRUCTURAL CHARACTERIZATION OF F62 LIPOOLIGOSACCHARIDE (LOS) OF NEISSERIA-GONORRHOEAE - IGM MONOCLONAL-ANTIBODIES (3F11 AND 1-1-M) RECOGNIZE NONREDUCING TERMINI OF THE LOS COMPONENTS SO MOLECULAR IMMUNOLOGY LA English DT Article ID ENDO-BETA-GALACTOSIDASE; ANTIGENIC EXPRESSION; SERUM RESISTANCE; MENINGITIDIS; OLIGOSACCHARIDES; HETEROGENEITY AB F62 LOS of Neisseria gonorrhoeae consists of two components. The higher molecular weight (MW) component is recognized by monoclonal antibody (MAb) 1-1-M and the smaller MW component by MAb 3F11. Epitope expression of the two LOS components and their partial structures were investigated by treating the F62 LOS with several glycosidases and then monitoring their antigenicity with the two mouse IgM MAbs. The 1-1-M-defined LOS component was cleaved with both beta-N-acetylhexosaminidase and endo-beta-galactosidase, and each cleavage resulted in the loss of expression of the 1-1-M-defined epitope. The N-acetylhexosamine (HexNAc) released by the hexosaminidase was found to be GalNAc, and the smaller oligosaccharide released by the endo enzyme was identified to be a dimer GalNAc-beta --> Gal. In contrast, the MAb 3F11-defined LOS component was not digested by the endo galactosidase, but it was cleaved with alpha and beta-galactosidase, and expression of the MAb 3F11-defined LOS epitope expression of the MAb 3F11-defined LOS was abolished by the treatment with each of two exo enzymes. MAb 3F11 bound to the 1-1-M-defined LOS component resulting from the removal of the beta-GalNAc residue, and the resulting LOS was further cleaved with beta-galactosidase, but not with alpha-galactosidase. From these results, we conclude the following: (1) MAbs 1-1-M and 3F11 both recognize the non-reducing termini of the LOS components; (2) the 1-1-M-defined LOS component has the GalNAc-beta - Gal-beta-1 --> 4-Glc (or GlcNAc) structure, and the GalNAc-beta --> Gal residue is involved in the MAb 1-1-M-defined epitope; (3) the MAb 3F11-defined LOS component may not have a Gal-beta-1 --> 4GlcNAc-beta-1 --> 4Gal-beta-1 --> 4Glc structure within the molecule. However, it has beta-Gal residue at its non-reducing terminus, and this residue is involved in the MAb 3F11-defined epitope; (4) the two LOS components share a similar antigenic structure, and the 3F11-defined epitope structure is present in the MAb 1-1-M-defined LOS component. Expression of this epitope within the 1-1-M-defined LOS molecule is blocked by the beta-1-GalNAc residue; however, the beta-GalNAc residue at the non-reducing end may be not the only structural difference between the two components. C1 UNIV CALIF SAN FRANCISCO,CTR IMMUNOCHEM,SAN FRANCISCO,CA 94143. UNIV CALIF SAN FRANCISCO,DEPT LAB MED,SAN FRANCISCO,CA 94143. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. SUNY BUFFALO,BUFFALO,NY 14260. FU NIAID NIH HHS [AI 18384, AI 22998] NR 20 TC 55 Z9 56 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0161-5890 J9 MOL IMMUNOL JI Mol. Immunol. PD NOV PY 1991 VL 28 IS 11 BP 1233 EP 1242 DI 10.1016/0161-5890(91)90010-H PG 10 WC Biochemistry & Molecular Biology; Immunology SC Biochemistry & Molecular Biology; Immunology GA GQ732 UT WOS:A1991GQ73200010 PM 1720505 ER PT J AU COWAN, DN BRUNDAGE, JF POMERANTZ, RS GARDNER, LI MILLER, RN WANN, ZF AF COWAN, DN BRUNDAGE, JF POMERANTZ, RS GARDNER, LI MILLER, RN WANN, ZF TI HIV-INFECTION AMONG MEMBERS OF THE ARMY RESERVE COMPONENTS RESIDING IN NEW-YORK-CITY SO NEW YORK STATE JOURNAL OF MEDICINE LA English DT Article ID IMMUNODEFICIENCY-VIRUS-INFECTION; UNITED-STATES-ARMY; YOUNG-ADULTS; AIDS; PREVALENCE; EPIDEMIC AB A total of 10,722 members of the US Army Reserve and Army National Guard residing within the five boroughs of New York City (NYC) were tested for antibody to human immunodeficiency virus (HIV). The crude prevalence in NYC was found to be 10.6 per 1,000, compared with a national prevalence of 1.6 per 1,000. The highest prevalences were found among Blacks and Hispanics, males, and among those aged 30-39 years. Patterns of infection were found to be similar to those found among heterosexual and drug abusing populations. Prevalence was highest in the Bronx and varied by less than twofold over all boroughs. Comparisons with reported cases of acquired immunodeficiency syndrome (AIDS) in New York City indicated differences in the demographic and geographic characteristics of the current epidemic of AIDS and HIV infection among members of the Army Reserve components. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP COWAN, DN (reprint author), SRA TECHNOL INC,4700 KING ST,SUITE 300,ALEXANDRIA,VA 22302, USA. NR 24 TC 4 Z9 4 U1 1 U2 1 PU MED SOC STATE OF NY PI LAKE SUCCESS PA 420 LAKEVILLE RD P O BOX 5404, LAKE SUCCESS, NY 11042 SN 0028-7628 J9 NEW YORK STATE J MED PD NOV PY 1991 VL 91 IS 11 BP 479 EP 482 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA GN360 UT WOS:A1991GN36000004 PM 1771042 ER PT J AU LETTERIE, GS STEVENSON, D SHAH, A AF LETTERIE, GS STEVENSON, D SHAH, A TI RECURRENT ANAPHYLAXIS TO A DEPOT FORM OF GNRH ANALOG SO OBSTETRICS AND GYNECOLOGY LA English DT Article AB Experience with depot forms of hormonal preparations suggests that severe adverse reactions are infrequent and immediate hypersensitivity reactions are rare. We report a case of recurrent anaphylaxis to a depot form of GnRH analogue requiring both acute and chronic management. C1 TRIPLER ARMY MED CTR,DEPT MED,ALLERGY & IMMUNOL SERV,HONOLULU,HI 96859. RP LETTERIE, GS (reprint author), TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,REPROD ENDOCRINOL SERV,HONOLULU,HI 96859, USA. NR 6 TC 11 Z9 11 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD NOV PY 1991 VL 78 IS 5 BP 943 EP 946 PN 2 PG 4 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA GL683 UT WOS:A1991GL68300022 PM 1923237 ER PT J AU SHEPARD, SM SASS, DT IMIROWICZ, T AF SHEPARD, SM SASS, DT IMIROWICZ, T TI ENHANCED TEMPORAL RESOLUTION WITH A SCANNING IMAGING RADIOMETER SO OPTICAL ENGINEERING LA English DT Article DE INFRARED IMAGING SYSTEMS; INFRARED THERMOGRAPHY; HIGH-SPEED VIDEO IMAGING AB A system has been developed that reduces the effective integration time of an off-shelf RS-170 optomechanical scanning imaging radiometer by two orders of magnitude. The system can be used to image repetitive thermal events at frequencies up to 4 kHz, without aliasing. The effective integration time of the system is 125-mu-s/frame. Examples include in-cylinder engine combustion and heat transfer in a transistor operating at 2.5 kHz. RP SHEPARD, SM (reprint author), USA,TANK AUTOMOT COMMAND,APPL RES BRANCH,AMSTA RSA,WARREN,MI 48397, USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD NOV PY 1991 VL 30 IS 11 BP 1716 EP 1719 DI 10.1117/12.55992 PG 4 WC Optics SC Optics GA GP209 UT WOS:A1991GP20900010 ER PT J AU ALTHOUSE, MLG CHANG, CI AF ALTHOUSE, MLG CHANG, CI TI CHEMICAL VAPOR DETECTION WITH A MULTISPECTRAL THERMAL IMAGER SO OPTICAL ENGINEERING LA English DT Article DE INFRARED IMAGING SYSTEMS; MULTISPECTRAL THERMAL IMAGING; CHEMICAL DETECTION; ADAPTIVE FILTERS; KALMAN FILTERING; VAPOR CLOUD MODEL ID SEGMENTATION AB Detection of chemical vapors with a remote sensor is necessary for both military defense and civilian pollution control. The thermal imager is a natural instrument from which to build a chemical sensor since most chemical vapors of interest are spectrally active in its operating wavelength range. A system has been designed to place a chemical detection capability as an adjunct function in a military thermal imager. An additional detector array, which is spectrally filtered at the focal plane, is added to the imager. Real-time autonomous detection and alarm is also required. A detection system model by Warren, based on a Gaussian vapor concentration distribution is the basis for detection algorithms. Algorithms recursive in both time and spectral frequency have been derived using Kalman filter theory. Adaptive filtering is used for preprocessing clutter rejection. Various components of the detection system have been tested individually and an integrated system is now being fabricated. C1 UNIV MARYLAND,DEPT ELECT ENGN,CATONSVILLE,MD 21228. RP ALTHOUSE, MLG (reprint author), USA,CTR CHEM RES DEV & ENG,SMCCR DDT,ABERDEEN PROVING GROUND,MD 21010, USA. NR 29 TC 15 Z9 15 U1 1 U2 4 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD NOV PY 1991 VL 30 IS 11 BP 1725 EP 1733 DI 10.1117/12.55995 PG 9 WC Optics SC Optics GA GP209 UT WOS:A1991GP20900012 ER PT J AU DOWLING, JP AF DOWLING, JP TI A QUANTUM STATE OF ULTRA-LOW PHASE NOISE SO OPTICS COMMUNICATIONS LA English DT Article AB A novel photon phase state is proposed that is similar to a recently advanced state by J.H. Shapiro, S.R. Shepard and N. Wong, Phys. Rev. Lett. 62 (1989) 2377. The new state given here has a phase distribution W-phi that has a sharply-peaked central maximum with a superposed broad background. The phase noise associated with the width of the best-fitting gaussian to the central peak decreases exponentially with increasing mean photon number. The state is mathematically more tractable and perhaps physically more realizable than previous constructions. RP DOWLING, JP (reprint author), USA,MISSILE COMMAND,CTR RES DEV & ENGN,AMSMI,RD,WS,WEAP SCI DIRECTORATE,REDSTONE ARSENAL,AL 35898, USA. RI DOWLING, JONATHAN/L-2749-2013 NR 13 TC 11 Z9 11 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0030-4018 J9 OPT COMMUN JI Opt. Commun. PD NOV 1 PY 1991 VL 86 IS 2 BP 119 EP 122 DI 10.1016/0030-4018(91)90545-O PG 4 WC Optics SC Optics GA GP936 UT WOS:A1991GP93600004 ER EF