FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Grace, J Peggins, J Aguilar, A Brewer, T AF Grace, J Peggins, J Aguilar, A Brewer, T TI Deethylation of arteether to dihydroqinghaosu by human liver cytochromes P-450. SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT PHARMACOL,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. AFRIMS,BANGKOK,THAILAND. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 1018 EP 1018 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28401018 ER PT J AU Thohan, S Weiner, M Petullo, D Chung, H AF Thohan, S Weiner, M Petullo, D Chung, H TI Use of liver slices for rapid in vitro assessment of bioactivation and toxicity. SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV MARYLAND,DEPT PHARMACEUT SCI,BALTIMORE,MD 21201. WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 1030 EP 1030 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28401030 ER PT J AU Marino, M Sperry, M Novotny, JF Chadda, SK AF Marino, M Sperry, M Novotny, JF Chadda, SK TI Assay for guanine N-7 nitrogen mustard adduct: A quantitable marker for DNA alkylation SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT PHARMACOL,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. STARK ASSOCIATES INC,BUFFALO,NY 14213. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 1043 EP 1043 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28401043 ER PT J AU Friedl, KE Westphal, KA Marchitelli, LJ AF Friedl, KE Westphal, KA Marchitelli, LJ TI Relationship between abdominal fat assessments and metabolic sequelae in healthy, young, non-obese women SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 1120 EP 1120 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28401122 ER PT J AU Elsayed, NM Gorbunov, NV Kozlov, AV Kagan, VE AF Elsayed, NM Gorbunov, NV Kozlov, AV Kagan, VE TI The antioxidant paradox: Prooxidant function of water soluble antioxidants, and antioxidant functions for nitric oxide against blast overpressure-induced oxidative stress. SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. UNIV CALIF LOS ANGELES,LOS ANGELES,CA 90024. UNIV PITTSBURGH,PITTSBURGH,PA 15238. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 1159 EP 1159 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28401159 ER PT J AU Gorbunov, NV Elsayed, NM Kisin, ER RItov, VB Gaddam, A Allan, WP Yalowich, JC Kagan, VE AF Gorbunov, NV Elsayed, NM Kisin, ER RItov, VB Gaddam, A Allan, WP Yalowich, JC Kagan, VE TI Nitrosylation of hemoglobin prevents alkylhydroperoxide-induced oxidative stress in erythroleukemia cells. SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV PITTSBURGH,PITTSBURGH,PA 15238. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 1160 EP 1160 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28401160 ER PT J AU Marchitelli, LJ Pusateri, AE Westphal, KA Whitehead, HR AF Marchitelli, LJ Pusateri, AE Westphal, KA Whitehead, HR TI Iron status of four populations of US Army women. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 1437 EP 1437 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28401436 ER PT J AU Bowman, PD Debaere, DR Lawlor, DF Schuschereba, ST AF Bowman, PD Debaere, DR Lawlor, DF Schuschereba, ST TI Induction of interleukin-8 in normal human keratinocytes by hyperthermia. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,INST SURG RES,FT SAM HOUSTON,TX 78234. USA,MED RES DEPT,BROOKS AFB,SAN ANTONIO,TX 78235. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 1508 EP 1508 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28401506 ER PT J AU Britton, P Dave, JR Lu, XCM Laskosky, MS Mestril, R Dillmann, WH Tortella, FC AF Britton, P Dave, JR Lu, XCM Laskosky, MS Mestril, R Dillmann, WH Tortella, FC TI Effect of focal cerebral ischemia in a transgenic mouse strain. Overexpressing the rat inducible 70-KD heat shock protein (rHSP-70i). SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. UNIV CALIF SAN DIEGO,LA JOLLA,CA 92093. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 1511 EP 1511 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28401513 ER PT J AU Kausalya, S Nath, J AF Kausalya, S Nath, J TI Neutrophil-endothelial cell interactions: Role of nitric oxide SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 1610 EP 1610 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28401609 ER PT J AU Sils, IV SzlykModrow, PC Tartarini, KA Francesconi, RP AF Sils, IV SzlykModrow, PC Tartarini, KA Francesconi, RP TI Effects of nitric oxide synthase inhibition on regional blood flow of the rat during hyperthermia. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 1912 EP 1912 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28401913 ER PT J AU Johnson, L Argyros, G Januszkiewicz, AJ Armstrong, K VanAlbert, SA Mayorga, MA AF Johnson, L Argyros, G Januszkiewicz, AJ Armstrong, K VanAlbert, SA Mayorga, MA TI Blast overpressure-induced cardiopulmonary injury in the pig. SO FASEB JOURNAL LA English DT Meeting Abstract C1 NATL DEF RES ESTAB,S-17290 STOCKHOLM,SWEDEN. WALTER REED ARMY INST RES,DEPT RESP RES,WASHINGTON,DC 20307. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 2000 EP 2000 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28402000 ER PT J AU Bossone, CA Dailey, M Januszkiewicz, AJ AF Bossone, CA Dailey, M Januszkiewicz, AJ TI Effect of splenectomy on maximal exercise performance in sheep. SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT RESP RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 2190 EP 2190 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28402188 ER PT J AU Bowers, W Blaha, M AF Bowers, W Blaha, M TI Cytokine and prostaglandin release from artificial human skin after exposure to irritants. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 2310 EP 2310 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28402308 ER PT J AU Casillas, RP Santai, CT France, J AF Casillas, RP Santai, CT France, J TI Cytokines as potential biomarkers of cutaneous vesicant injury. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,EDGEWOOD,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 2434 EP 2434 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28402434 ER PT J AU BakerFulco, CJ Buchbinder, JC Torri, SA AF BakerFulco, CJ Buchbinder, JC Torri, SA TI Effect of smoking on alcohol consumption by Marine Officer Candidates School students. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,INST ENVIRONM MED,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 2807 EP 2807 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28402807 ER PT J AU Hotson, NG Tharion, WJ Lieberman, HR AF Hotson, NG Tharion, WJ Lieberman, HR TI The effect of a carbohydrate beverage on hydration state SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,INST ENVIRONM MED,MIL NUTR DIV,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 2812 EP 2812 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28402812 ER PT J AU DuBose, DA Shippee, RL Gaffin, S AF DuBose, DA Shippee, RL Gaffin, S TI Effect of moderate heat stress (HS) and/or endotoxin (ET) on the cytokine response (CR) by human whole blood (HWB) under in vitro conditions. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 3318 EP 3318 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28403318 ER PT J AU Dubick, MA Keen, CL DiSilvestro, RA Eskelson, CD Hunter, GC AF Dubick, MA Keen, CL DiSilvestro, RA Eskelson, CD Hunter, GC TI Aortic antioxidant enzyme activity in human aneurysmal and occlusive disease. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,INST SURG RES,SAN ANTONIO,TX 78234. UNIV CALIF DAVIS,DAVIS,CA 95616. OHIO STATE UNIV,COLUMBUS,OH 43210. UNIV ARIZONA,TUCSON,AZ 85724. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 3365 EP 3365 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28403365 ER PT J AU Atkins, J Johnson, K Pearce, F AF Atkins, J Johnson, K Pearce, F TI Oxygen inhalation after hemorrhage increases mean arterial blood pressure (MABP) even when changes in PaCO2 are prevented. SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 3450 EP 3450 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28403451 ER PT J AU Sondeen, JL Coppes, VG Carpenter, L Dubick, MA AF Sondeen, JL Coppes, VG Carpenter, L Dubick, MA TI Model of hemorrhagic shock (HS) with renal ischemia reperfusion (I/R) injury induced by hypoperfusion of both kidneys in the conscious rabbit. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,INST SURG RES,SAN ANTONIO,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 3457 EP 3457 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28403455 ER PT J AU Krakauer, T AF Krakauer, T TI Sensitive ELISA for measuring the adhesion of leukocytic cells to human endothelial cells SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FT DETRICK,MD 21702. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 3523 EP 3523 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28403525 ER PT J AU Neal, D Kokes, J Hewetson, J Pitt, L Assaad, A AF Neal, D Kokes, J Hewetson, J Pitt, L Assaad, A TI Pulmonary myeloperoxidase activity in ricin-intoxicated rats. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 3700 EP 3700 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28403700 ER PT J AU SzlykModrow, PC Gentile, BJ Sils, IV Tartarini, KA Krestel, BA Francesconi, RP AF SzlykModrow, PC Gentile, BJ Sils, IV Tartarini, KA Krestel, BA Francesconi, RP TI Ventilatory responses to hypothermia and rewarming. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 3706 EP 3706 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28403706 ER PT J AU Forte, VA Muza, SR Fulco, CS Lyons, T Rock, PB Beidleman, BA Young, AJ Sawka, MN Cymerman, A AF Forte, VA Muza, SR Fulco, CS Lyons, T Rock, PB Beidleman, BA Young, AJ Sawka, MN Cymerman, A TI Smoking accentuates the decrement in maximal oxygen uptake at high altitude. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 3723 EP 3723 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28403723 ER PT J AU Zamastil, DE Lyons, TP Fulco, CS Muza, SR Rock, PB Cymerman, A AF Zamastil, DE Lyons, TP Fulco, CS Muza, SR Rock, PB Cymerman, A TI Short-term exposure to high altitude causes decreases in total body water measured by bioelectrical impedance. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 3732 EP 3732 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28403733 ER PT J AU Pusateri, AE Marchitelli, LJ Whitehead, HR Cline, AD AF Pusateri, AE Marchitelli, LJ Whitehead, HR Cline, AD TI Incidence of menstrual abnormalities in female army soldiers. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 3743 EP 3743 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28403744 ER PT J AU McFaul, SJ Villa, VM AF McFaul, SJ Villa, VM TI Hematin stimulates MNL to release TNF-alpha and IL8. SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 3817 EP 3817 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28403816 ER PT J AU Ashcom, J Stiles, B AF Ashcom, J Stiles, B TI Fluorescein-labeled alpha-conotoxin GI binds specifically to the torpedo nicotinic acetylcholine receptor and to protective monoclonal antibodies. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 3974 EP 3974 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28403972 ER PT J AU Genovese, R Newman, D Kavanagh, J Gordon, K Brewer, T AF Genovese, R Newman, D Kavanagh, J Gordon, K Brewer, T TI DQHS disrupts auditory discrimination performance in rats in the absence of brainstem pathology. SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 4132 EP 4132 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28404131 ER PT J AU Sheridan, RE Deshpande, SS AF Sheridan, RE Deshpande, SS TI Structural features of aminoquinolines necessary for antagonism of botulinum intoxication. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 4164 EP 4164 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28404164 ER PT J AU Ding, XZ Smallridge, RC Tsokos, GC Kiang, JG AF Ding, XZ Smallridge, RC Tsokos, GC Kiang, JG TI Regulation of heat shock gene expression in double gene-transfected human epidermoid A-431 cells. SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT CLIN PHYSIOL,DIV MED,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 4400 EP 4400 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28404401 ER PT J AU ColdenStanfield, M Burrous, J Kanesathasan, N AF ColdenStanfield, M Burrous, J Kanesathasan, N TI Effect of dengue virus (DV) on leukocyte adherence and endothelial adhesion molecule expression. SO FASEB JOURNAL LA English DT Meeting Abstract C1 MOREHOUSE SCH MED,ATLANTA,GA 30310. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 4433 EP 4433 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28404432 ER PT J AU Cline, AD Patton, JF Mello, RP Lieberman, HR AF Cline, AD Patton, JF Mello, RP Lieberman, HR TI Iron status, physical activity, and aerobic power of women entering Army office training. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,MIL NUTR DIV,NATICK,MA 01760. USA,ENVIRONM MED RES INST,OCCUPAT PHYSIOL DIV,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 4530 EP 4530 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28404528 ER PT J AU Narayan, KA Porcella, C Bradley, RR Robertson, M AF Narayan, KA Porcella, C Bradley, RR Robertson, M TI Pancreatic alpha-amylase undigestible resistant starch in bread: Effect of pretreatment SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,NATICK RES DEV & ENGN CTR,SOLDIER SYST COMMAND,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 8 PY 1996 VL 10 IS 3 BP 4585 EP 4585 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA TZ284 UT WOS:A1996TZ28404585 ER PT J AU Bieler, CR Sanov, A Capellos, C Reisler, H AF Bieler, CR Sanov, A Capellos, C Reisler, H TI Molecular beams studies of the dissociation of highly excited NO2 induced by molecular colliders SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Article ID CONTROLLING BIMOLECULAR REACTIONS; BOND SELECTED REACTION; ENERGY-TRANSFER; HYDROGEN-ATOMS; DIODE-LASER; EXCITATION; WATER; MODE AB NO2 in high vibrational levels was prepared in a pulsed molecular beam by laser excitation of the mixed 1(2)A(1)/2(2)B(2) state to energies h nu below dissociation threshold D-0, D-0 - h nu = 0-500 cm(-1). The beam of excited molecules was crossed with pulsed, neat molecular beams of HCl, CO2, N2O, and NH3 at relative collision energies of similar to 2000 cm(-1), and the NO produced by collision-induced dissociation (CID) was detected state-selectively. The CID yield spectra obtained by monitoring specific NO rotational levels while scanning the excitation wavelength show spectral features identical with those in the fluorescence excitation spectrum of NO2. The yield of the CID products, however, decreases exponentially (compared with the fluorescence spectrum) with the increase of the amount of energy required to reach the threshold of appearance of the monitored NO state. The average energy transferred per activating collision with polyatomic colliders is in the range 130-200 cm(-1), having values similar to or lower than those for diatomic and atomic colliders. This is in contrast to deactivating collisions, in which polyatomic colliders are in general more effective. The results are discussed in terms of a mechanism in which the NO2 molecules are activated by impulsive collisions creating a distribution of molecules in quantum states above D-0 whose populations diminish exponentially with energy. The collisional activation is followed by unimolecular decomposition. The differences between the activation and deactivation pathways are rationalized in terms of the number of degrees of freedom available for energy transfer in each channel. C1 UNIV SO CALIF,DEPT CHEM,LOS ANGELES,CA 90089. USA,ARDEC,PICATINNY ARSENAL,AMSTA AR AEE,DOVER,NJ 07801. NR 37 TC 6 Z9 6 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD MAR 7 PY 1996 VL 100 IS 10 BP 3882 EP 3887 DI 10.1021/jp952663m PG 6 WC Chemistry, Physical SC Chemistry GA TY919 UT WOS:A1996TY91900002 ER PT J AU Hines, JF Ghim, SJ Jenson, AB AF Hines, JF Ghim, SJ Jenson, AB TI Human papillomavirus infection - Pathogenesis suggests new strategies for preventing and treating chemical dysplasia and cancer SO BRITISH MEDICAL JOURNAL LA English DT Editorial Material ID CELLS C1 GEORGETOWN UNIV,MED CTR,DEPT PATHOL,WASHINGTON,DC 20007. RP Hines, JF (reprint author), BROOKE ARMY MED CTR,DEPT OBSTET & GYNECOL,GYNECOL ONCOL SERV,FT SAM HOUSTON,TX 78234, USA. NR 12 TC 1 Z9 3 U1 0 U2 0 PU BRITISH MED JOURNAL PUBL GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON, ENGLAND WC1H 9JR SN 0959-8138 J9 BRIT MED J JI Br. Med. J. PD MAR 2 PY 1996 VL 312 IS 7030 BP 522 EP 523 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA TY885 UT WOS:A1996TY88500002 PM 8595268 ER PT J AU Thomas, WJ Steiman, DM Kovach, JA Vernalis, MN AF Thomas, WJ Steiman, DM Kovach, JA Vernalis, MN TI Doppler echocardiography and hemodynamic findings in localized pericardial constriction SO AMERICAN HEART JOURNAL LA English DT Article ID RESTRICTIVE CARDIOMYOPATHY RP Thomas, WJ (reprint author), WALTER REED ARMY MED CTR,CARDIOL SERV 4A,DEPT MED,WASHINGTON,DC 20307, USA. NR 8 TC 3 Z9 3 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0002-8703 J9 AM HEART J JI Am. Heart J. PD MAR PY 1996 VL 131 IS 3 BP 599 EP 603 DI 10.1016/S0002-8703(96)90543-8 PG 5 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA TZ295 UT WOS:A1996TZ29500025 PM 8604644 ER PT J AU Jacobs, LD Cookfair, DL Rudick, RA Herndon, RM Richert, JR Salazar, AM Fischer, JS Goodkin, DE Granger, CV Simon, JH Alam, JJ Bartoszak, DM Bourdette, DN Braiman, J Brownscheidle, CM Coats, ME Cohan, SL Dougherty, DS Kinkel, RP Mass, MK Munschauer, FE Priore, RL Pullicino, PM Scherokman, BJ WeinstockGuttman, B Whitman, RH Baird, WC Fillmore, M Bona, LM ColonRuiz, ME Nadine, BS Donovan, A Bennett, S Kieffer, YM Umhauer, MA Miller, CE Kilic, AK Sargent, EL Schachter, M Shucard, DW Weider, V Catalano, BA Cervi, JM Czekay, C Farrell, JL Filippini, JS Matyas, RC Michienzi, KE Ito, M OMalley, JA Zielezny, MA Brun, JM Davidson, AL Green, LA OReilly, KM Shelton, JA Wende, KE Barilla, DY Boyle, SL Perkins, KK Perryman, JE Stiebeling, BG Konecsni, JF Ross, JS Choi, KS Gustafson, CJ Quandt, BJ Scherzinger, AL Griffith, DA Harris, JM Lezak, MD Mimica, I Saunders, JA Coit, WE Force, CR Gilmore, FJ Harris, LB Jones, MM Kauffman, JA Marberger, KE McBride, JW Miller, LL Wright, GK Brooks, JA Brown, HR Graves, ME Schmidt, JA Mothena, JW Grafman, JH Kenworthy, MK Morton, MM Brown, DM Brown, DC Levy, LM Borden, EC Ransohoff, RM Vilcek, JT McCarthyKirby, K Campion, M AF Jacobs, LD Cookfair, DL Rudick, RA Herndon, RM Richert, JR Salazar, AM Fischer, JS Goodkin, DE Granger, CV Simon, JH Alam, JJ Bartoszak, DM Bourdette, DN Braiman, J Brownscheidle, CM Coats, ME Cohan, SL Dougherty, DS Kinkel, RP Mass, MK Munschauer, FE Priore, RL Pullicino, PM Scherokman, BJ WeinstockGuttman, B Whitman, RH Baird, WC Fillmore, M Bona, LM ColonRuiz, ME Nadine, BS Donovan, A Bennett, S Kieffer, YM Umhauer, MA Miller, CE Kilic, AK Sargent, EL Schachter, M Shucard, DW Weider, V Catalano, BA Cervi, JM Czekay, C Farrell, JL Filippini, JS Matyas, RC Michienzi, KE Ito, M OMalley, JA Zielezny, MA Brun, JM Davidson, AL Green, LA OReilly, KM Shelton, JA Wende, KE Barilla, DY Boyle, SL Perkins, KK Perryman, JE Stiebeling, BG Konecsni, JF Ross, JS Choi, KS Gustafson, CJ Quandt, BJ Scherzinger, AL Griffith, DA Harris, JM Lezak, MD Mimica, I Saunders, JA Coit, WE Force, CR Gilmore, FJ Harris, LB Jones, MM Kauffman, JA Marberger, KE McBride, JW Miller, LL Wright, GK Brooks, JA Brown, HR Graves, ME Schmidt, JA Mothena, JW Grafman, JH Kenworthy, MK Morton, MM Brown, DM Brown, DC Levy, LM Borden, EC Ransohoff, RM Vilcek, JT McCarthyKirby, K Campion, M TI Intramuscular interferon beta-1 alpha for disease progression in relapsing multiple sclerosis SO ANNALS OF NEUROLOGY LA English DT Article ID HUMAN FIBROBLAST INTERFERON; SUPPRESSOR-CELL-FUNCTION; STATUS SCALE EDSS; REDUCES EXACERBATIONS; DOUBLE-BLIND; BETA; MULTICENTER; IMPAIRMENT; ACTIVATION; TRIAL AB The accepted standard treatment of relapsing multiple sclerosis consists of medications for disease symptoms, including treatment for acute exacerbations. However, currently there is no therapy that alters the progression of physical disability associated with this disease. The purpose of this study was to determine whether interferon beta-la could slow the progressive, irreversible, neurological disability of relapsing multiple sclerosis. Three hundred one patients with relapsing multiple sclerosis were randomized into a double-blinded, placebo-controlled, multicenter phase III trial of interferon beta-la. Interferon beta-la, 6.0 million units (30 mu g), was administered by intramuscular injection weekly. The primary outcome variable was time to sustained disability progression of at least 1.0 point on the Kurtzke Expanded Disability Status Scale (EDSS). Interferon beta-la treatment produced a significant delay in time to sustained EDSS progression (p = 0.02). The Kaplan-Meier estimate of the proportion of patients progressing by the end of 104 weeks was 34.9% in the placebo group and 21.9% in the interferon beta-la-treated group. Patients treated with interferon beta-la also had significantly fewer exacerbations (p = 0.03) and a significantly lower number and volume of gadolinium-enhanced brain lesions on magnetic resonance images (p-values ranging between 0.02 and 0.05). Over 2 years, the annual exacerbation rate was 0.90 in placebo-treated patients versus 0.61 in interferon beta-la-treated patients. There were no major adverse events related to treatment. Interferon beta-la had a significant beneficial impact in relapsing multiple sclerosis patients by reducing the accumulation of permanent physical disability, exacerbation frequency, and disease activity measured by gadolinium-enhanced lesions on brain magnetic resonance images. This treatment may alter the fundamental course of relapsing multiple sclerosis. C1 WILLIAM C BAIRD MULTIPLE SCLEROSIS RES CTR, MILLARD FILLMORE HLTH SYST, BUFFALO, NY USA. BUFFALO GEN HOSP, MSCRG, DATA MANAGEMENT & STAT CTR, DEPT NEUROL, BUFFALO, NY 14203 USA. CLEVELAND CLIN FDN, MELLEN CTR MULTIPLE SCLEROSIS TREATMENT & RES, CLEVELAND, OH 44195 USA. HOSP GOOD SAMARITAN, DEPT NEUROL, PORTLAND, OR USA. MED CTR, PORTLAND, OR USA. GEORGETOWN UNIV, MED CTR, DEPT NEUROL, WASHINGTON, DC 20007 USA. WALTER REED ARMY MED CTR, DEPT NEUROL, WASHINGTON, DC 20307 USA. UNIV CALIF SAN FRANCISCO, MT ZION MULTIPLE SCLEROSIS CTR, SAN FRANCISCO, CA 94143 USA. SUNY BUFFALO, SCH MED & BIOMED SCI, DEPT REHABIL MED, BUFFALO, NY USA. UNIV COLORADO, HLTH SCI CTR, DEPT RADIOL MRI, DENVER, CO USA. OREGON HLTH SCI UNIV, DEPT NEUROL, PORTLAND, OR 97201 USA. BIOGEN INC, CAMBRIDGE, MA 02142 USA. KAISER PERMANENTE MED CTR, DEPT NEUROL, SPRINGFIELD, VA USA. RP Jacobs, LD (reprint author), BUFFALO GEN HOSP, DEPT NEUROL, 100 HIGH ST, BUFFALO, NY 14203 USA. FU PHS HHS [R01-26321] NR 34 TC 1789 Z9 1811 U1 11 U2 59 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0364-5134 EI 1531-8249 J9 ANN NEUROL JI Ann. Neurol. PD MAR PY 1996 VL 39 IS 3 BP 285 EP 294 DI 10.1002/ana.410390304 PG 10 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA UC473 UT WOS:A1996UC47300003 PM 8602746 ER PT J AU Hamilton, HR AF Hamilton, HR TI Planning at the Crossroads - Simmie,L SO ANNALS OF THE ASSOCIATION OF AMERICAN GEOGRAPHERS LA English DT Book Review DE containment; critiques; crossroads; Green Belts; monitoring; planning RP Hamilton, HR (reprint author), USA,ENGINEER WATERWAYS EXPT STN,ENVIRONM LAB,VICKSBURG,MS 39180, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHERS PI CAMBRIDGE PA 350 MAIN STREET, STE 6, CAMBRIDGE, MA 02148-5023 SN 0004-5608 J9 ANN ASSOC AM GEOGR JI Ann. Assoc. Am. Geogr. PD MAR PY 1996 VL 86 IS 1 BP 180 EP 181 PG 2 WC Geography SC Geography GA UB739 UT WOS:A1996UB73900026 ER PT J AU Gillespie, DL Carringion, LR Griffin, JH Alving, BM AF Gillespie, DL Carringion, LR Griffin, JH Alving, BM TI Resistance to activated protein C: A common inherited cause of venous thrombosis SO ANNALS OF VASCULAR SURGERY LA English DT Article; Proceedings Paper CT 20th Annual Meeting of the Peripheral-Vascular-Surgery-Society CY JUN 10, 1995 CL NEW ORLEANS, LA SP Peripheral Vasc Surg Soc ID POOR ANTICOAGULANT RESPONSE; THROMBOPHILIA AB Resistance to activated protein C (RAPC) is a newly recognized hypercoagulable state that was first described in 1993. It has become apparent that RAPC is even more common than deficiencies in protein C, protein S, or antithrombin III (AT-III) and affects an estimated 5% of the general population. The majority of patients with RAPC have an abnormality in factor V (Arg506Gln), which renders factor Va resistant to degradation by activated protein C. Studies in 75 patients referred to the Hematology Laboratory at Waiter Reed Army Institute of Research (WRAIR) over a 14-month period for evaluation of venous thromboembolism were reviewed to determine the percentage of those with RAPC, Of the 75 patients in the study, one was deficient in protein S, one was deficient in protein C, and none was deficient in AT-III. in contrast, 27 (36%) patients tested positive for RAPC. Blood was available for DNA analysis in 15 patients with RAPC. Of these 15 patients, nine (60%) tested positive for the Arg506Gln mutation in factor V. Six other patients with RAPC did not have the factor V mutation. Additional risk factors for thrombosis were immobility, obesity, use of oral contraceptives, and pregnancy. The majority of patients had deep venous thrombosis of the lower extremities; 71% had a recurrence if not placed on chronic anticoagulation therapy, Thus RAPC is a significant risk factor for venous thrombosis. Evaluation for inherited hypercoagulable states should include testing for this newly described condition. C1 WALTER REED ARMY INST RES, DEPT HEMATOL & VASC BIOL, WASHINGTON, DC USA. SCRIPPS RES INST, LA JOLLA, CA USA. RP Gillespie, DL (reprint author), WALTER REED ARMY MED CTR, DEPT VASC SURG, WARD 64, WASHINGTON, DC 20307 USA. FU NHLBI NIH HHS [R37-HL52246] NR 11 TC 9 Z9 9 U1 0 U2 0 PU QUALITY MEDICAL PUBLISHING INC PI ST LOUIS PA 11970 BORMAN DR, STE 222, ST LOUIS, MO 63146 SN 0890-5096 J9 ANN VASC SURG JI Ann. Vasc. Surg. PD MAR PY 1996 VL 10 IS 2 BP 174 EP 177 DI 10.1007/BF02000762 PG 4 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA UK572 UT WOS:A1996UK57200011 PM 8733870 ER PT J AU Pham, MQK Harvey, SP Weigand, WA Bentley, WE AF Pham, MQK Harvey, SP Weigand, WA Bentley, WE TI Reactor comparisons for the biodegradation of thiodiglycol, a product of mustard gas hydrolysis SO APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY LA English DT Article; Proceedings Paper CT 17th Symposium on Biotechnology for Fuels and Chemicals CY MAY 07-11, 1995 CL VAIL, CO SP US DOE, Off Alternat Fuels, US DOE, Off Ind Proc, Natl Renewable Energy Lab, Oak Ridge Natl Lab, Idaho Natl Engn Lab, Argonne Natl Lab, A E Staley Mfg Co, Archer Daniel Midland Co, Bio Tech Resources L P, Chronopol Inc, Colorado Inst Res Biotechnol, Dow Chem, DuPont Co, Enzyme Bio Syst Ltd, FermPro Mfg L P, Gist Brocades, Golden Technol Co Inc, Grain Proc Corp, Martin Marietta Energy Syst, Natl Corn Growers Assoc, New Energy Co Indiana, L P, Raphael Katzen Associated Int Inc, S Point Ethanol, St Lawrence Technol Inc, Weyerhaeuser, Amer Chem Soc, Div Biochem Technol DE biodegradation; chemical warfare agents; sulfur mustard; thiodiglycol AB An environmentally benign method for the mineralization of sulfur mustard has been proposed involving chemical hydrolysis of sulfur mustard to thiodiglycol, and then the biological degradation of thiodiglycol to generate biomass and gaseous carbon dioxide. Alcaligenes xylosoxidans (SH91) was isolated based on its ability to utilize thiodiglycol as a sole carbon source. This article compares different biological reactor designs and experimentally assesses their relative effectiveness in degrading thiodiglycol using pure cultures of SH91. The reactor configurations studied are batch, continuous stirred-tank reactor (CSTR), and CSTR with cell recycle. From the results, it is clear that the CSTR with cell recycle offers superior performance for a given residence time or volume. These pure culture data are necessary for accurate design of a pilot-scale system where mixed cultures will be employed because of a possible incomplete chemical hydrolysis step. C1 UNIV MARYLAND,INST BIOTECHNOL,DEPT CHEM ENGN,COLLEGE PK,MD 20742. UNIV MARYLAND,INST BIOTECHNOL,AGR BIOTECHNOL CTR,COLLEGE PK,MD 20742. USA,EDGEWOOD RES,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD. NR 7 TC 9 Z9 11 U1 0 U2 0 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 SN 0273-2289 J9 APPL BIOCHEM BIOTECH JI Appl. Biochem. Biotechnol. PD SPR PY 1996 VL 57-8 BP 779 EP 789 DI 10.1007/BF02941758 PG 11 WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology GA UL857 UT WOS:A1996UL85700078 PM 8669917 ER PT J AU Barekman, CL Adair, CF AF Barekman, CL Adair, CF TI Immunohistochemistry of pneumocytes in hyperplasia and neoplasia SO APPLIED IMMUNOHISTOCHEMISTRY LA English DT Article DE bronchioloalveolar carcinoma; pneumocyte hyperplasia; immunohistochemistry Lung ID PULMONARY ADENOCARCINOMA; PLEURAL MESOTHELIOMA; LUNG-CANCER AB A panel of immunohistochemical markers was employed to evaluate its utility in distinguishing between well-differentiated adenocarcinoma of the lung, bronchioloalveolar type, and reactive hyperplasia of type 2 pneumocytes. We studied 20 cases of bronchioloalveolar carcinoma, 10 with separate areas of pneumocyte hyperplasia, and 19 cases of non-neoplastic lung conditions with pneumocyte hyperplasia. The panel of markers included Leu M-l, B72.3, carcinoembryonic antigen (CEA), both monoclonal and polyclonal, and human milk-fat globule protein. The sensitivities and specificities of these antibodies as ''tumor markers'' are as follows: Leu M-l, sensitivity 85%, specificity 97%; B72.3, sensitivity 80%, specificity 100%; monoclonal CEA, sensitivity 50%, specificity 90%; and polyclonal CEA, sensitivity 50%, specificity 76%. The human milk-fat globule protein was positive in most reactive and neoplastic processes, with a sensitivity of 70% and a specificity of only 3%. The best combination of markers for discriminating between carcinoma and reactive pneumocytes was Leu M-l and B72,3, with 13 of the bronchioloalveolar carcinomas positive for both, but none of the hyperplasias positive for both. C1 WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. NR 13 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1062-3345 J9 APPL IMMUNOHISTOCHEM JI Appl. Immunohistochem. PD SPR PY 1996 VL 4 IS 1 BP 61 EP 65 PG 5 WC Anatomy & Morphology; Medical Laboratory Technology; Pathology SC Anatomy & Morphology; Medical Laboratory Technology; Pathology GA TX885 UT WOS:A1996TX88500007 ER PT J AU Nachman, P Chen, G Pinnick, RG Hill, SC Chang, RK Mayo, MW Fernandez, GL AF Nachman, P Chen, G Pinnick, RG Hill, SC Chang, RK Mayo, MW Fernandez, GL TI Conditional-sampling spectrograph detection system for fluorescence measurements of individual airborne biological particles SO APPLIED OPTICS LA English DT Article ID STEADY-STATE; RESONANCES; MICRODROPLETS; EMISSION; AEROSOL AB We report the design and operation of a prototype conditional-sampling spectrograph detection system that can record the fluorescence spectra of individual, micrometer-sized aerosols as they traverse an intense 488-nm intracavity laser beam. The instrument's image-intensified CCD detector is gated by elastic scattering or by undispersed fluorescence from particles that enter the spectrograph's field of view. It records spectra only from particles with preselected scattering-fluorescence levels (a fiber-optic-photomultiplier subsystem provides the gating signal). This conditional-sampling procedure reduces data-handling rates and increases the signal-to-noise ratio by restricting the system's exposures to brief periods when aerosols traverse the beam. We demonstrate these advantages by reliably capturing spectra from individual fluorescent microspheres dispersed in an airstream. The conditional-sampling procedure also permits some discrimination among different types of particles, so that spectra may be recorded from the few interesting particles present in a cloud of background aerosol. We demonstrate such discrimination by measuring spectra from selected fluorescent microspheres in a mixture of two types of microspheres, and from bacterial spores in a mixture of spores and nonfluorescent kaolin particles. (C) 1996 Optical Society of America C1 YALE UNIV,DEPT APPL PHYS,NEW HAVEN,CT 06520. SYST & PROC ENGN CORP,AUSTIN,TX 78746. NEW MEXICO STATE UNIV,DEPT PHYS,LAS CRUCES,NM 88003. RP Nachman, P (reprint author), USA,RES LAB,WHITE SANDS MISSILE RANGE,NM 88002, USA. NR 29 TC 36 Z9 38 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD MAR 1 PY 1996 VL 35 IS 7 BP 1069 EP 1076 DI 10.1364/AO.35.001069 PG 8 WC Optics SC Optics GA UA058 UT WOS:A1996UA05800011 PM 21085216 ER PT J AU Galasso, FS Fenner, DB Lynds, L Rossman, CE Potrepka, DM Budnick, JI Carreiro, LG AF Galasso, FS Fenner, DB Lynds, L Rossman, CE Potrepka, DM Budnick, JI Carreiro, LG TI An assessment of synthesis effects on the high-T-c superconducting transition: With application to thin-film bolometer devices SO APPLIED SUPERCONDUCTIVITY LA English DT Article ID LIQUID-NITROGEN TEMPERATURE; TRANSPORT CRITICAL-CURRENT; O SYSTEM; BULK SUPERCONDUCTIVITY; COMPOUND SYSTEM; Y1BA2CU3O7-DELTA; YBA2CU3O7-DELTA; MICROSTRUCTURE; LA AB The characteristics of the transition to superconductivity in RBa(2)Cu(3)O((7-delta)), where R includes: Y, Gd, Eu and Dy, have been investigated, for applications to transition-edge thin-film bolometers. Devices were fabricated from thin, epitaxial films, which were formed by pulsed-laser deposition (PLD). Bulk ceramic samples (pellets) were synthesized for use as the ablation targets. A study of the (DC) resistive transition width (Delta T-c) of the bulk samples, reveals that the oxidation annealing cycle plays a dominant role in determining Delta T-c. Peak temperatures of the oxygenation must be very carefully controlled. A slightly too high processing temperature causes changes in the grain-surface morphology and an increase in Delta T-c. Rare earth (R) substitution has a significant effect. Residual phase impurity, off stoichiometry, lower density, pressing-induced orientation and smaller pellet sizes, were all found to be less deleterious to Delta T-c. Proper synthesis improves superconductivity, narrowing Delta T-c and affecting grain-boundary (GB) morphology, as revealed by XRD, SEM and AC magnetic susceptibility analyses of the bulk ceramics. The occurrence of a substantial susceptibility-loss (chi '') peak correlates well with (undesired) larger Delta T-c transitions. In bulk ceramics this may be accompanied by a toe feature in the resistive transition, i.e. additional width to the lower-half of the transition. Thin, epitaxial films, made by PLD from these same bulk ceramics, indicate that certain types of non-optimal features of the bulk transition are not present in the fabricated films. In particular, the toe feature is removed due to the complete restructuring that occurs during the epitaxial film-growth process by PLD. For films to have narrow transitions, we find that it is necessary for the ablation target to have a sharp onset to its transition. The relationship to infrared bolometer detectors is discussed and examples are reported. C1 AFR INC,E HARTFORD,CT 06108. UNIV CONNECTICUT,DEPT PHYS,STORRS,CT 06268. USA,MAT TECHNOL LAB,WATERTOWN,MA 02172. RP Galasso, FS (reprint author), UNITED TECHNOL RES CTR,E HARTFORD,CT 06108, USA. NR 43 TC 0 Z9 0 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0964-1807 J9 APPL SUPERCOND JI Appl. Supercond. PD MAR PY 1996 VL 4 IS 3 BP 119 EP 133 DI 10.1016/S0964-1807(96)00019-1 PG 15 WC Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA WJ374 UT WOS:A1996WJ37400001 ER PT J AU Young, TD AF Young, TD TI German national command structures after unification: A new German general staff? SO ARMED FORCES & SOCIETY LA English DT Article AB The Bundeswehr was intentionally created in 1955 without the capability to exercise centralized operational control above the Army Corps, or at the joint, level. The reason for this situation was German and Allied anxiety over the recreation of a ''Generalstab.'' With unification, Germany now requires the ability to employ the Bundeswehr in less than war operations, which, therefore, requires a modest national capability to direct operations outside of NATO wartime command structures, i.e., a ''J-3.'' This article details the evolution in the development of the modest centralization of operational control structures in the German Ministry of Defense and within the three armed services themselves. Integral to understanding this slow and stilted evolution in the MoD and the Bundeswehr is the sensitivity that continues to overshadow many key aspects of civil-military relations in the Federal Republic of Germany. RP Young, TD (reprint author), USA,WAR COLL,STRATEG STUDIES INST,CARLISLE,PA 17013, USA. NR 12 TC 2 Z9 2 U1 0 U2 1 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD SPR PY 1996 VL 22 IS 3 BP 379 EP & DI 10.1177/0095327X9602200303 PG 24 WC Political Science; Sociology SC Government & Law; Sociology GA UH929 UT WOS:A1996UH92900003 ER PT J AU Carland, J AF Carland, J TI Vietnam documents: American and Vietnamese views of the war - Katsiaficas,G SO ARMED FORCES & SOCIETY LA English DT Book Review RP Carland, J (reprint author), USA,CTR MIL HIST,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD SPR PY 1996 VL 22 IS 3 BP 501 EP 502 DI 10.1177/0095327X9602200315 PG 2 WC Political Science; Sociology SC Government & Law; Sociology GA UH929 UT WOS:A1996UH92900015 ER PT J AU Wildzunas, RM Barron, TL Wiley, RW AF Wildzunas, RM Barron, TL Wiley, RW TI Visual display delay effects on pilot performance SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID WORKLOAD AB Background: The Helmet Integrated Display Sight System (HIDSS), originally proposed for the RAH-66 Comanche, displays sensor data from FLIR and image intensifiers, as well as flight instrument and targeting data. All these data will be processed through onboard computers before being displayed on miniature CRT's. In addition to processing delays, delays also are arising from the helmet tracker and from sensor slewing that may increase the total visual display delay to as much as 250 ms. Methods: Because display lag is one of the most important limitations affecting the ability of an aviator to use a display, we investigated the effects of 0, 67, 133, 267, 400, and 533 ms visual display delays on the flight performance of 10 volunteer U.S. Army aviators in a full motion flight simulator. Results: There were few performance decrements at 67, 133, or 267 ms delays as compared with the 0 ms delay condition. Significant performance decrements consistently were observed at 400 and 533 ms delays. Conclusions: Given the anticipated visual display delays for the proposed system, flight performance, as measured within the range of flight conditions and profiles examined, should not be affected significantly, although the aviators will experience an increase in workload to compensate for the delay effects. During low level flight, they will face additional risk due to their proximity to obstacles and a resulting decrease in their time to react and avoid collisions. Given the high accident rates, further research to investigate training strategies to offset delay effects clearly is necessary. RP Wildzunas, RM (reprint author), USA,AEROMED RES LAB,POB 620577,FT RUCKER,AL 36362, USA. NR 30 TC 10 Z9 10 U1 1 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD MAR PY 1996 VL 67 IS 3 BP 214 EP 221 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA TY364 UT WOS:A1996TY36400003 PM 8775398 ER PT J AU Sumfest, JM AF Sumfest, JM TI Pseudoureterocele - Reply SO BRITISH JOURNAL OF UROLOGY LA English DT Letter RP Sumfest, JM (reprint author), TRIPLER ARMY MED CTR,HONOLULU,HI 96859, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0007-1331 J9 BRIT J UROL JI Br. J. Urol. PD MAR PY 1996 VL 77 IS 3 BP 478 EP 478 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA TZ248 UT WOS:A1996TZ24800041 ER PT J AU Hwang, HM Maloney, SW AF Hwang, HM Maloney, SW TI A study of microbial transformations of trichloroaniline and p-cresol using size-fractionation technique SO BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article ID DEGRADATION; KINETICS; WATER C1 USA,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL 61826. RP Hwang, HM (reprint author), JACKSON STATE UNIV,DEPT BIOL,JACKSON,MS 39217, USA. FU NIGMS NIH HHS [GM08047] NR 18 TC 5 Z9 5 U1 1 U2 1 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0007-4861 J9 B ENVIRON CONTAM TOX JI Bull. Environ. Contam. Toxicol. PD MAR PY 1996 VL 56 IS 3 BP 343 EP 350 PG 8 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA TM935 UT WOS:A1996TM93500001 PM 8825954 ER PT J AU Goodpaster, AJ Berman, H Blechman, BM Burns, WF Horner, CA Jeffords, JM Krepon, M McNamara, RS Marshall, W Nitze, PH Nolan, JE Odeen, PA Ridgway, RL Sagan, SD Smith, WY Steinbruner, J Utgoff, V AF Goodpaster, AJ Berman, H Blechman, BM Burns, WF Horner, CA Jeffords, JM Krepon, M McNamara, RS Marshall, W Nitze, PH Nolan, JE Odeen, PA Ridgway, RL Sagan, SD Smith, WY Steinbruner, J Utgoff, V TI A four-step program to nuclear disarmament SO BULLETIN OF THE ATOMIC SCIENTISTS LA English DT Article C1 USA,WAR COLL,WASHINGTON,DC 20310. US SPACE COMMAND,COLORADO SPRINGS,CO. USAF,SPACE COMMAND,WASHINGTON,DC 20330. BROOKINGS INST,FOREIGN POLICY STUDIES PROGRAM,WASHINGTON,DC 20036. INST DEF ANAL,STRATEGY FORCES RESOURCE DIV,PRINCETON,NJ. NR 0 TC 0 Z9 0 U1 0 U2 0 PU EDUC FOUNDATION NUCLEAR SCI PI CHICAGO PA 6042 SOUTH KIMBARK, CHICAGO, IL 60637 SN 0096-3402 J9 B ATOM SCI JI Bull. Atom. Scient. PD MAR-APR PY 1996 VL 52 IS 2 BP 52 EP 55 PG 4 WC International Relations; Social Issues SC International Relations; Social Issues GA TZ909 UT WOS:A1996TZ90900021 ER PT J AU Berenberg, JL AF Berenberg, JL TI Phase II study of 5-Fluorouracil and folinic acid in the treatment of patients with advanced gastric cancer - A Southwest Oncology Group Study - Reply SO CANCER LA English DT Letter DE . RP Berenberg, JL (reprint author), TRIPLER ARMY MED CTR,CANC RES CTR HAWAII,HONOLULU,HI 96859, USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD MAR 1 PY 1996 VL 77 IS 5 BP 1002 EP 1003 DI 10.1002/(SICI)1097-0142(19960301)77:5<1002::AID-CNCR30>3.0.CO;2-5 PG 2 WC Oncology SC Oncology GA TW395 UT WOS:A1996TW39500030 ER PT J AU Kommareddi, NS Tata, M John, VT McPherson, GL Herman, MF Lee, YS OConnor, CJ Akkara, JA Kaplan, DL AF Kommareddi, NS Tata, M John, VT McPherson, GL Herman, MF Lee, YS OConnor, CJ Akkara, JA Kaplan, DL TI Synthesis of superparamagnetic polymer-ferrite composites using surfactant microstructures SO CHEMISTRY OF MATERIALS LA English DT Article ID IRON-OXIDES; PARTICLES; MICROEMULSIONS; MICELLES AB Superparamagnetic microspheres are prepared by incorporating nanometer-sized iron oxide crystals into micron-sized phenolic polymer particles. The synthesis of ferrite particles is conducted in the structured environment of water-in-oil microemulsions (reversed micelles). This is followed by the enzymatic polymerization of p-ethylphenol. The polymer precipitates in spherical morphologies and during precipitation incorporates ferrite nanocrystals into the polymeric matrix. SQUID (superconducting quantum interference device) generated magnetic hysteresis loops exhibit zero remanence and coercivity for the ferrite-polymer composite at room temperature, indicating the superparamagnetic nature of the composite. At very low temperatures, hysteretic effects, nonzero remanence, and coercivity are seen. Spin glass behavior is apparent at low temperatures from de magnetic susceptibility measurements. Thermal and isothermal remanent magnetization measurements confirm the existence of the spin glass state. The composites exhibit blocking temperatures in the range 12.0-27.0 K. TEM micrographs of sectioned composite particles show that the iron oxide component is uniformly distributed in the polymer matrix. C1 TULANE UNIV,DEPT CHEM ENGN,NEW ORLEANS,LA 70118. TULANE UNIV,DEPT CHEM,NEW ORLEANS,LA 70118. UNIV NEW ORLEANS,DEPT CHEM,NEW ORLEANS,LA 70148. USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. RI John, Vijay/G-3747-2010 NR 31 TC 89 Z9 89 U1 1 U2 6 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0897-4756 J9 CHEM MATER JI Chem. Mat. PD MAR PY 1996 VL 8 IS 3 BP 801 EP 809 DI 10.1021/cm940485o PG 9 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA UA826 UT WOS:A1996UA82600029 ER PT J AU Snyder, AP AF Snyder, AP TI Qualitative and quantitative characterization of a microencapsulated protein with pyrolysis-atmospheric pressure ionization mass spectrometry SO CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS LA English DT Article DE pyrolysis; microencapsulation; protein; mass spectroscopy; multivariate analysis ID MYCOPLASMA-HYOPNEUMONIAE VACCINE; ENTERIC-COATED MICROSPHERES; CELLULOSE-ACETATE PHTHALATE; DESIGN-BASED OPTIMIZATION; CHEMICAL-IONIZATION; ENCAPSULATED ENZYME; FACTORIAL DESIGN; RELEASE BEHAVIOR; BIO-POLYMERS; MICROCAPSULES AB Solid, microencapsulated protein as well as the microencapsulating species were investigated for their qualitative and semi-quantitative characterization. Quartz tube pyrolysis (Py) was used to process the solid sample and the selective and sensitive technique of atmospheric pressure ionization quadrupole mass spectrometry (API-MS) was chosen for the analysis. Selected protein and technical polymer standards provided a reference identification data set for the microencapsulated samples, and the standards data set was subjected to multivariate and graphical analysis procedures for semi-quantitative assessment of the microencapsulate components. API, however, is an ionization technique that produces nonlinear analyte responses when a mixture of compounds is present in the ion source as opposed to the technique of electron ionization. Concentration and proton affinity determine the relative distribution of compound mass spectral responses in API. The sample microencapsulate compounds were found to contain derivatives of polyhexose polymers as the encapsulating species, and poor semi-quantitative information was obtained for these microcapsule shell polymers. The fy-API technique, however, produced satisfactory semi-quantitative information for the core protein analyte of interest. Protein pyrolyzate products have relatively high proton affinities because of the saturated and unsaturated nitrogen functional groups as compared to the shell material which contains oxygen functional groups. Approximately 15% of the Py-API mass spectral response was attributed to complex proteinaceous substances, and was confirmed by independent experiments. RP Snyder, AP (reprint author), USA,EDGEWOOD RES,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010, USA. NR 43 TC 0 Z9 0 U1 2 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-7439 J9 CHEMOMETR INTELL LAB JI Chemometrics Intell. Lab. Syst. PD MAR PY 1996 VL 32 IS 2 BP 233 EP 243 PG 11 WC Automation & Control Systems; Chemistry, Analytical; Computer Science, Artificial Intelligence; Instruments & Instrumentation; Mathematics, Interdisciplinary Applications; Statistics & Probability SC Automation & Control Systems; Chemistry; Computer Science; Instruments & Instrumentation; Mathematics GA UB004 UT WOS:A1996UB00400008 ER PT J AU Shorr, AF Trotta, MRF AF Shorr, AF Trotta, MRF TI PZA hypersensitivity SO CHEST LA English DT Letter RP Shorr, AF (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 2 TC 3 Z9 3 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD MAR PY 1996 VL 109 IS 3 BP 855 EP 856 DI 10.1378/chest.109.3.855 PG 2 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA UA043 UT WOS:A1996UA04300060 PM 8617112 ER PT J AU Oaks, EV Picking, WD Picking, WL AF Oaks, EV Picking, WD Picking, WL TI Antibody response of monkeys to invasion plasmid antigen D after infection with Shigella spp. SO CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY LA English DT Article ID RHESUS-MONKEYS; FLEXNERI 2A; LIPOPOLYSACCHARIDES; IMMUNOGENICITY; SAFETY; HUMANS AB The antigen preparation most often used for determining the levels of antibodies to virulence-associated proteins of Shigella spp. consists of a mixture of proteins (including IpaB, IpaC, IpaD, and VirG*) extracted from virulent shigellae with water (water extract). To overcome the lack of specificity for individual antigens in the water-extract enzyme-linked immunosorbent assay (ELISA), the ipaD gene from S. flexneri has been cloned, expressed to a high level, acid purified for use in a nem ELISA for the determination of the levels of antibody against IpaD in monkeys and humans challenged with shigellae. The IpaD ELISA for serum immunoglobulins G and A correlated well with the water-extract ELISA in that monkeys infected with S. flexneri or S. sonnei responded with high serum antibody titers in both assays. The IpaD assay required less antigen per well, had much lower background levels, and did not require correction with antigens from an avirulent organism. In conjunction with the water-extract ELISA, it was possible to identify infected animals that did not respond to IpaD but did produce antibodies that reacted in the water-extract ELISA. This indicates that even though IpaB, IpaC, and IpaD are essential for the invasiveness phenotype, the infected host does not always produce antibodies against all components of the invasiveness apparatus. C1 ST LOUIS UNIV,DEPT BIOL,ST LOUIS,MO 63103. RP Oaks, EV (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTER INFECT,WASHINGTON,DC 20307, USA. NR 15 TC 12 Z9 13 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 1071-412X J9 CLIN DIAGN LAB IMMUN JI Clin. Diagn. Lab. Immunol. PD MAR PY 1996 VL 3 IS 2 BP 242 EP 245 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA TY857 UT WOS:A1996TY85700022 PM 8991646 ER PT J AU Dinauer, PA Balingit, AG Rivera, JE AF Dinauer, PA Balingit, AG Rivera, JE TI Tc-99m sestamibi imaging of brown tumors of primary hyperparathyroidism SO CLINICAL NUCLEAR MEDICINE LA English DT Article ID SCINTIGRAPHY AB Double-phase scintigraphy using Tc-99m sestamibi MIBI is the study of choice for detecting parathyroid adenoma in patients with primary hyperparathyroidism. However, before parathyroid imaging, these patients may uncommonly present with multiple osteolytic lesions and bone scan findings consistent with metastatic disease, By excluding malignancy, the diagnosis of osteitis fibrosa cystica and parathyroid adenoma may subsequently be confirmed, The authors describe the case of an elderly patient who presented with imaging findings initially masquerading as metastatic disease, When parathyroid adenoma was finally diagnosed with Tc-99m MIBI imaging, radiopharmaceutical uptake was also noted within several brown tumors, including clinically significant brown tumors of the left lower extremity, a finding that has not been previously reported. C1 WALTER REED ARMY MED CTR,NUCL MED SERV,WASHINGTON,DC 20307. RP Dinauer, PA (reprint author), WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307, USA. NR 20 TC 17 Z9 17 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD MAR PY 1996 VL 21 IS 3 BP 192 EP 196 DI 10.1097/00003072-199603000-00002 PG 5 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA TZ555 UT WOS:A1996TZ55500002 PM 8846562 ER PT J AU Scully, SP Temple, HT OKeefe, RJ Mankin, HJ Gebhardt, M AF Scully, SP Temple, HT OKeefe, RJ Mankin, HJ Gebhardt, M TI The surgical treatment of patients with osteosarcoma who sustain a pathologic fracture SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Article ID OSTEOGENIC-SARCOMA; EXPERIENCE AB The presence of pathologic fracture in osteosarcoma raises concerns of tumor dissemination by the fracture hematoma and has been considered a contraindication to limb salvage surgery, Because this is a theoretical concern, there are little clinical data available in the literature on which to base treatment of these patients, Eighteen patients with osteosarcoma who sustained a pathologic fracture and had a minimum of 24 months of followup were reviewed retrospectively. Surgical treatment included nonoperative therapy, amputation, and limb salvage groups, Patients who refused surgical intervention (2) had a uniformly poor outcome, Patients who underwent amputation (6) had no local recurrences and 33% developed metastases. Patients who underwent limb salvage (10) experienced 3 local recurrences and 6 distant recurrences, Although the distant recurrence rate for patients undergoing amputation was no different from the rate for those undergoing limb salvage, the difference in local tumor control approached statistical significance, All patients who developed local recurrence died, Surgical treatment needs to be individualized and based on factors such as fracture displacement, stability, radiographic and histologic response to chemotherapy, and the perceived ability to resect the fracture hematoma completely. C1 UNIV ROCHESTER,ROCHESTER,NY. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. MASSACHUSETTS GEN HOSP,ORTHOPAED ONCOL UNIT,BOSTON,MA 02114. RP Scully, SP (reprint author), DUKE UNIV,MED CTR,BOX 3312,DURHAM,NC 27710, USA. NR 10 TC 40 Z9 43 U1 0 U2 2 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0009-921X J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD MAR PY 1996 IS 324 BP 227 EP 232 PG 6 WC Orthopedics; Surgery SC Orthopedics; Surgery GA TX968 UT WOS:A1996TX96800028 PM 8595761 ER PT J AU Shay, SS Richter, JE AF Shay, SS Richter, JE TI Origin of atypical reflux symptoms - A case study showing the importance of reflux composition and posture SO DIGESTIVE DISEASES AND SCIENCES LA English DT Article DE gastroesophageal reflux; posture; atypical reflux symptoms ID GASTROESOPHAGEAL REFLUX; ESOPHAGUS; CLEARANCE C1 WALTER REED ARMY MED CTR,GASTROENTEROL SERV,WASHINGTON,DC 20307. RP Shay, SS (reprint author), CLEVELAND CLIN FDN,DEPT GASTROENTEROL S40,9500 EUCLID AVE,CLEVELAND,OH 44195, USA. NR 10 TC 5 Z9 5 U1 0 U2 0 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0163-2116 J9 DIGEST DIS SCI JI Dig. Dis. Sci. PD MAR PY 1996 VL 41 IS 3 BP 505 EP 511 DI 10.1007/BF02282326 PG 7 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA UB267 UT WOS:A1996UB26700010 PM 8617123 ER PT J AU Jarvis, AS Honeycutt, ME McFarland, VA Bulich, AA Bounds, HC AF Jarvis, AS Honeycutt, ME McFarland, VA Bulich, AA Bounds, HC TI A comparison of the ames assay and Mutatox in assessing the mutagenic potential of contaminated dredged sediment SO ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY LA English DT Article ID SALMONELLA MICROSOME TEST; GENOTOXIC COMPONENTS; BLACK RIVER; CHEMICAL CHARACTERIZATION; AROMATIC-HYDROCARBONS; GREAT-LAKES; BIOASSAY; AGENTS; WATER; CARCINOGENS AB The ability of the Ames assay and of Mutatox to identify the genotoxic potential of dredged sediments was compared. The Ames assay has been used extensively in the testing of environmental contaminants, whereas Mutatox, a new bacterial bioluminescence test, has only recently been used for this purpose. Ten sediments with varying degrees of contamination were soxhlet extracted. Each of the 10 extracts was split with half remaining in a crude form and half cleaned using silica gel chromatography, resulting in 20 extract samples. Both the Ames assay (using Salmonella typhimurium strains TA98 and TA100) and Mutatox were conducted with and without S9 metabolic activation. When metabolically activated, TA98 and TA100 indicated a positive mutagenic response in 80 and 50%, respectively, of the sediment extracts. Without S9 activation, TA98 indicated a positive mutagenic response with half the extracts, whereas only 10% did so with TA100. Mutatox indicated a positive mutagenic response with S9 activation in 75% of the extracts and no mutagenic response in any of the sediment extracts without metabolic activation. In a side-by-side comparison of the Ames assay (TA98 with S9) and Mutatox, 80% of the sediment extracts had similar responses, both positive and negative. Fifty percent of the sediment extracts had similar responses when tested with TA100 and Mutatox in the presence of S9. Mutatox compared reasonably well with the Ames assay but was insensitive to the presence of direct-acting mutagens in the sediments tested. Although Mutatox demonstrates promise as a screening tool to assess sediment genotoxicity, the authors consider it appropriate to use the Ames assay as a confirmation for definitive investigations. (C) 1996 Academic Press, Inc. C1 MICROB CORP,CARLSBAD,CA 92008. NE LOUISIANA UNIV,DEPT BIOL,MONROE,LA 71209. RP Jarvis, AS (reprint author), USA,ENGINEER WATERWAYS EXPT STN,CEWES,ES F,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 53 TC 25 Z9 27 U1 0 U2 7 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0147-6513 J9 ECOTOX ENVIRON SAFE JI Ecotox. Environ. Safe. PD MAR PY 1996 VL 33 IS 2 BP 193 EP 200 DI 10.1006/eesa.1996.0025 PG 8 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA UJ172 UT WOS:A1996UJ17200013 PM 8723758 ER PT J AU Torrens, JI Burch, HB AF Torrens, JI Burch, HB TI Serum thyroglobulin measurement: Utility in clinical practice SO ENDOCRINOLOGIST LA English DT Review ID DIFFERENTIATED THYROID-CARCINOMA; TOTAL-BODY SCAN; IMMUNORADIOMETRIC ASSAY IRMA; FOLLOW-UP; TL-201 SCINTIGRAPHY; SUPPRESSION THERAPY; I-131 UPTAKE; ANTITHYROGLOBULIN ANTIBODIES; HASHIMOTOS THYROIDITIS; POSTPARTUM THYROIDITIS AB Serum thyroglobulin (TG) levels continue to play a critical role in the diagnosis and management of a variety of thyroid disorders. In no situation is this more evident than in the management of patients afflicted with thyroid cancer. The ability to measure serum TG has not only significantly improved the management of these patients, but has also raised a number of new, clinically relevant questions. The intent of this article is to review the clinical utility of serum TG in a variety of thyroid disorders, with particular emphasis on the management of differentiated thyroid cancer. Assay limitations and potential solutions to these difficulties will be discussed. C1 WALTER REED ARMY MED CTR,DEPT MED,ENDOCRINE METAB SERV,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 239 TC 6 Z9 6 U1 0 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1051-2144 J9 ENDOCRINOLOGIST JI Endocrinologist PD MAR PY 1996 VL 6 IS 2 BP 125 EP 144 DI 10.1097/00019616-199603000-00010 PG 20 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA UJ169 UT WOS:A1996UJ16900010 ER PT J AU McClellan, DR Francis, GL AF McClellan, DR Francis, GL TI Thyroid cancer in children, pregnant women, and patients with Graves' disease SO ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA LA English DT Review ID SERUM THYROGLOBULIN MEASUREMENTS; FOLLOW-UP; NECK IRRADIATION; EPIDEMIOLOGIC EVIDENCE; NEEDLE ASPIRATION; YOUNG AGE; CARCINOMA; CHILDHOOD; NODULES; I-131 AB Thyroid cancer may have a different clinical course when it occurs in children, pregnant women, and patients with Graves' disease. In this section, an approach to the diagnosis and management of differentiated thyroid carcinoma in this group of patients is reviewed. C1 UNIFORMED SERV UNIV HLTH SCI, DEPT PEDIAT, DIV PEDIAT ENDOCRINOL, BETHESDA, MD 20814 USA. WALTER REED ARMY MED CTR, DEPT PEDIAT, WASHINGTON, DC 20307 USA. NR 111 TC 52 Z9 53 U1 0 U2 2 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0889-8529 EI 1558-4410 J9 ENDOCRIN METAB CLIN JI Endocrinol. Metabol. Clin. North Amer. PD MAR PY 1996 VL 25 IS 1 BP 27 EP + DI 10.1016/S0889-8529(05)70311-X PG 0 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA TZ614 UT WOS:A1996TZ61400003 PM 8907679 ER PT J AU Galloway, RJ Smallridge, RC AF Galloway, RJ Smallridge, RC TI Imaging in thyroid cancer SO ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA LA English DT Article ID SOMATOSTATIN RECEPTOR SCINTIGRAPHY; POSITRON EMISSION TOMOGRAPHY; MEDULLARY CARCINOMA; FOLLOW-UP; DIMERCAPTOSUCCINIC ACID; TL-201 SCINTIGRAPHY; SERUM THYROGLOBULIN; THALLIUM 201; BODY SCAN; I-131 AB This article discusses the major noninvasive imaging techniques available to evaluate patients fur thyroid malignancy and identify metastatic disease. In addition to discussing the advantages and disadvantages of each modality, circumstances under which a given modality might be particularly useful are emphasized. A special section on medullary thyroid cancer is included. C1 WALTER REED ARMY INST RES, DIV MED, WASHINGTON, DC USA. WALTER REED ARMY INST RES, DEPT CLIN PHYSIOL, WASHINGTON, DC USA. NR 70 TC 37 Z9 40 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0889-8529 EI 1558-4410 J9 ENDOCRIN METAB CLIN JI Endocrinol. Metabol. Clin. North Amer. PD MAR PY 1996 VL 25 IS 1 BP 93 EP + DI 10.1016/S0889-8529(05)70314-5 PG 0 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA TZ614 UT WOS:A1996TZ61400006 PM 8907682 ER PT J AU Knapik, JJ Banderet, LE Vogel, JA Bahrke, MS OConnor, JS AF Knapik, JJ Banderet, LE Vogel, JA Bahrke, MS OConnor, JS TI Influence of age and physical training on measures of cardiorespiratory and muscle endurance SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY LA English DT Article DE muscle contraction; exertion; exercise; military personnel ID HUMAN SKELETAL-MUSCLE; CROSS-SECTIONAL AREA; SEDENTARY MALES; ACTIVITY LEVEL; MOVEMENT TIME; ELDERLY MEN; OLDER MEN; YOUNG; EXERCISE; STRENGTH AB This study describes associations between age, physical training and measures of muscle and cardiorespiratory endurance. The subjects were 5079 healthy male soldiers aged 18-53 years from 14 Army installations in the United States. The subjects completed as many push-ups as possible in 2 min, as many sit-ups as possible in 2 min, and performed a timed 3.2-km run. The training level was assessed by asking the subjects two questions about the frequency (times each week) and duration (hours each week) of their physical training. For all three performance events there were significant declines with age, but at a given age, groups that trained more demonstrated higher performance levels than groups that trained less. For the 3.2-km run, the age-associated rate of performance decline was less in the groups that trained more, and greater amounts of training resulted in progressively less performance decline with age. For push-ups and sit-ups, the training level did not systematically influence the age-related rate of performance decline. The results suggest that tasks involving different physiological systems may be influenced differentially by age and training. Training may slow age-associated performance declines in tasks requiring cardiorespiratory endurance but not in tasks requiring muscle endurance. C1 USA,ENVIRONM MED RES INST,OCCUPAT HLTH & PERFORMANCE DIRECTORATE,NATICK,MA 01760. USA,PHYS FITNESS SCH,FT BENNING,GA 31905. RP Knapik, JJ (reprint author), USA,RES LAB,HUMAN RES & ENGN DIRECTORATE,SOLDIER PERFORMANCE DIV,ATTN AMSRL,HR,SB KNAPIK,ABERDEEN PROVING GROUND,MD 21005, USA. NR 54 TC 4 Z9 4 U1 0 U2 1 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0301-5548 J9 EUR J APPL PHYSIOL O JI Eur. J. Appl. Physiol. Occup. Physiol. PD MAR PY 1996 VL 72 IS 5-6 BP 490 EP 495 DI 10.1007/BF00242280 PG 6 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA TZ752 UT WOS:A1996TZ75200015 PM 8925821 ER PT J AU Elsayed, NM Tyurina, YY Tyurin, VA Menshikova, EV Kisin, ER Kagan, VE AF Elsayed, NM Tyurina, YY Tyurin, VA Menshikova, EV Kisin, ER Kagan, VE TI Antioxidant depletion, lipid peroxidation, and impairment of calcium transport induced by air-blast overpressure in rat lungs SO EXPERIMENTAL LUNG RESEARCH LA English DT Article DE oxidative stress; lipid peroxidation; antioxidants; vitamin E; vitamin C; thiols; Ca2+ transport; air-blast overpressure; free radicals ID SUPEROXIDE-DISMUTASE; N-ACETYLCYSTEINE; INJURY; HEMORRHAGE; RADICALS; STRESS; MUSCLE AB Exposure to blast overpressure, or the sudden rise in atmospheric pressure after explosive detonation, results in damage mainly of the gas-filled organs. In addition to the physical damage, in the lung, injury may proceed via a hemorrhage-dependent mechanism initiating oxidative stress and accumulation of lipid peroxidation products. Massive rupture of capillaries and red blood cells, release of hemoglobin, its oxidation to met-hemoglobin and degradation sets the stage for heme-catalyzed oxidations. The authors hypothesized that lipid hydroperoxides interact with met-hemoglobin in the lungs of exposed animals to produce ferryl-hemoglobin, an extremely potent oxidant that induces oxidative damage by depleting antioxidants and initiating peroxidation reactions. Oxidation-induced disturbance of Ca2+ homeostasis facilitates further amplification of the damage. To test this hypothesis, groups of anesthetized rats (6 rats/group) were exposed to blast at 3 peak pressures: low (61.2 kPa), medium (95.2 kPa), high (136 kPa). One group served as an unexposed control. Immediately after exposure, the rats were euthanized and the lungs were analyzed for biochemical parameters. Blast overpressure caused: (1) depletion of total and water-soluble pulmonary antioxidant reserves and individual antioxidants (ascorbate, vitamin E, GSH), (2) accumulation of lipid peroxidation products (conjugated dienes, TBARS), and (3) inhibition of ATP-dependent Ca2+ transport. The magnitude of these changes in the lungs were proportional to the peak blast overpressure. Inhibition of Ca2+ transport strongly correlated with both depletion of antioxidants and enhancement of lipid peroxidation. In model experiments, met-hemoglobin/H2O2 produced damage to Ca2+ transport in the lungs from control animals similar to that observed in the lungs from blast overpressure-exposed animals. Ascorbate, which is known to reduce ferryl-hemoglobin, protected against met-hemoglobin/H2O2-induced damage of Ca2+ transport. If ferryl-hemoglobin is the major reactive oxygen species released by hemorrhage, then its specific reductants (e.g., nitric oxide) along with other antioxidants may be beneficial protectants against pulmonary barotrauma. C1 UNIV CALIF LOS ANGELES,SCH PUBL HLTH,DEPT ENVIRONM & OCCUPAT HLTH SCI,LOS ANGELES,CA 90024. UNIV PITTSBURGH,DEPT ENVIRONM & OCCUPAT HLTH,PITTSBURGH,PA. PITTSBURGH CANC INST,PITTSBURGH,PA 15213. RP Elsayed, NM (reprint author), WALTER REED ARMY INST RES,DEPT RESP RES,DIV MED,WASHINGTON,DC 20307, USA. OI Tyurin, Vladimir/0000-0002-3474-1697 NR 51 TC 21 Z9 22 U1 0 U2 0 PU HEMISPHERE PUBL CORP PI BRISTOL PA 1900 FROST ROAD, SUITE 101, BRISTOL, PA 19007-1598 SN 0190-2148 J9 EXP LUNG RES JI Exp. Lung Res. PD MAR-APR PY 1996 VL 22 IS 2 BP 179 EP 200 DI 10.3109/01902149609050846 PG 22 WC Respiratory System SC Respiratory System GA UB888 UT WOS:A1996UB88800004 PM 8706635 ER PT J AU Gilbert, JA Huang, Q AF Gilbert, JA Huang, Q TI Characterization, production and reconstruction of substrate guided wave holointerferograms SO EXPERIMENTAL MECHANICS LA English DT Article DE holography; interferometry; nondestructive testing ID HOLOGRAMS AB Substrate guided wave (SGW) holograms are recorded and reconstructed using light waves guided through an optical substrate. The recording geometries for producing transmission and reflection SGW holograms are discussed. Practical guidelines are presented for recording and reconstructing interferograms suitable for nondestructive testing. C1 USA,MISSILE COMMAND,WEAPON SCI DIRECTORATE,REDSTONE ARSENAL,AL 35898. RP Gilbert, JA (reprint author), UNIV ALABAMA,DEPT MECH & AEROSP ENGN,HUNTSVILLE,AL 35899, USA. NR 12 TC 1 Z9 1 U1 0 U2 1 PU SOC EXPERIMENTAL MECHANICS PI BETHEL PA 7 SCHOOL STREET, BETHEL, CT 06801 SN 0014-4851 J9 EXP MECH JI Exp. Mech. PD MAR PY 1996 VL 36 IS 1 BP 71 EP 77 DI 10.1007/BF02328700 PG 7 WC Materials Science, Multidisciplinary; Mechanics; Materials Science, Characterization & Testing SC Materials Science; Mechanics GA UH488 UT WOS:A1996UH48800010 ER PT J AU Chiang, PK Gordon, RK Tal, J Zeng, GC Doctor, BP Pardhasaradhi, K McCann, PP AF Chiang, PK Gordon, RK Tal, J Zeng, GC Doctor, BP Pardhasaradhi, K McCann, PP TI S-adenosylmethionine and methylation SO FASEB JOURNAL LA English DT Review DE AdoMet synthesis; AdoHcy hydrolase; protein methylation ID EUKARYOTIC DNA METHYLATION; ADENOSYL-L-METHIONINE; MESSENGER-RNA; GENE-EXPRESSION; CELL-LINES; TERATOCARCINOMA CELLS; CPG DINUCLEOTIDES; ESCHERICHIA-COLI; VIRUS; METHYLTRANSFERASE AB S-Adenosylmethionine (AdoMet or SAM) plays a pivotal role as a methyl donor in a myriad of biological and biochemical events, Although it has been claimed that AdoMet itself has therapeutic benefits, it remains to be established whether it can be taken up intact by cells, S-Adenosylhomocysteine (AdoHcy), formed after donation of the methyl group of AdoMet to a methyl acceptor, is then hydrolyzed to adenosine and homocysteine by AdoHey hydrolase. This enzyme has long been a target for inhibition as its blockade can affect methylation of phospholipids, proteins, DNA, RNA, and other small molecules, Protein carboxymethylation may he involved in repair functions of aging proteins, and heat shock proteins are methylated in response to stress. Bacterial chemotaxis involves carboxymethylation and demethylation in receptor-transducer proteins, although a similar role in mammalian cells is unclear. The precise role of phospholipid methylation remains open, DNA methylation is related to mammalian gene activities, somatic inheritance, and cellular differentiation. Activation of some genes has been ascribed to the demethylation of critical mCpG loci, and silencing of some genes may be related to the methylation of specific CpG loci, Viral DNA genomes exist in cells as extrachromosomal units and are generally not methylated, although once integrated into host chromosomes, different patterns of methylation are correlated with altered paradigms of transcriptional activity, Some viral latency may be related to DNA methylation, Cellular factors have been found to interact with methylated DNA sequences, Methylation of mammalian ribosomal RNAs occurs soon after the synthesis of its 47S precursor RNA in the nucleolus before cleavage to smaller fragments. Inhibition of the methylation of rRNA affects its processing to mature 18S and 28S rRNAs, The methylation of 5'-terminal cap plays an important role in mRNA export from the nucleus, efficient translation, and protection of the integrity of mRNAs, Another important function of AdoMet is that it serves as the sole donor of an aminopropyl group that is conjugated with putrescine to form, first, the polyamine spermidine, and then spermine. C1 UNIFORMED SERV UNIV HLTH SCI, F EDWARD HEBERT SCH MED, DEPT PHARMACOL, BETHESDA, MD 20814 USA. BRITISH BIOTECH INC, ANNAPOLIS, MD 21401 USA. RP Chiang, PK (reprint author), WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, WASHINGTON, DC 20307 USA. NR 99 TC 516 Z9 544 U1 11 U2 62 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 EI 1530-6860 J9 FASEB J JI Faseb J. PD MAR PY 1996 VL 10 IS 4 BP 471 EP 480 PG 10 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA UE557 UT WOS:A1996UE55700011 PM 8647346 ER PT J AU Waag, DM Sandstrom, G England, MJ Williams, JC AF Waag, DM Sandstrom, G England, MJ Williams, JC TI Immunogenicity of a new lot of Francisella tularensis live vaccine strain in human volunteers SO FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY LA English DT Article; Proceedings Paper CT 1st International Conference on Tularemia CY AUG 23-25, 1995 CL UMEA, SWEDEN DE vaccine; tularemia; human ID HUMORAL IMMUNITY; HUMAN TULAREMIA; DIAGNOSIS AB A new lot of Francisella tularensis live vaccine strain (LVS) was tested for immunogenicity in 19 human volunteers, Scarification vaccination induced specific cell-mediated and humoral immune responses, We noted a significant rise in antibodies against irradiation-killed LVS, formalin-killed virulent strain SCHU4, and an ether extracted antigen preparation (EEx) beginning 14 days after vaccination. A main target of the humoral immune response was lipopolysaccharide. Eighty percent of vaccinated volunteers developed a positive Ige response to EEx by day 14 and 100% of vaccinees responded positively by day 21, Background IgA titers were lower than corresponding IgG or IgM titers, No early IgM rise was noted with any antigen, By day 14 after vaccination, in vitro lymphocyte responses to LVS,the rough variant of LVS, and EEx were significantly increased compared to controls, Seventy percent of volunteers had a positive in vitro lymphocyte response to EEx within 14 days of vaccination, We predict that EEx will be a useful antigen or diagnosing tularemia and for evaluating the immunogenicity of vaccines against tularemia. We are testing this antigen using sera from human cases of tularemia and control sera. C1 NATL DEF RES ESTAB,DEPT MICROBIOL,S-90182 UMEA,SWEDEN. UMEA UNIV,DEPT INFECT DIS,S-90185 UMEA,SWEDEN. RP Waag, DM (reprint author), USA,MED RES INST INFECT DIS,PATHOGENESIS & IMMUNOL BRANCH,BACTERIOL DIV,FREDERICK,MD 21702, USA. NR 9 TC 17 Z9 18 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0928-8244 J9 FEMS IMMUNOL MED MIC JI FEMS Immunol. Med. Microbiol. PD MAR PY 1996 VL 13 IS 3 BP 205 EP 209 DI 10.1111/j.1574-695X.1996.tb00238.x PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA UG974 UT WOS:A1996UG97400007 PM 8861030 ER PT J AU Hallet, B Hunter, L Bogen, J AF Hallet, B Hunter, L Bogen, J TI Rates of erosion and sediment evacuation by glaciers: A review of field data and their implications SO GLOBAL AND PLANETARY CHANGE LA English DT Article; Proceedings Paper CT Workshop on Glacial Cycles - Effects on the Physical Environment CY MAY 30-JUN 02, 1994 CL FJAERLAND, NORWAY ID ICE STREAM-B; SOUTHERN ALPS; NEW-ZEALAND; UPLIFT; FJORDS; DEFORMATION; EVOLUTION; CLIMATE; ALASKA; OCEAN AB Diverse field data on glacial sediment yields are assembled in the context of the current interest in sedimentary basin development in glaciated regions, and in controversial linkages between global climate and topography. Attention herein is directed at sediment yields, including both overall bedrock erosion and evacuation of sediments stored in glaciated basins over several years or decades. These yields, expressed as effective rates of glacial erosion, vary by orders of magnitude from 0.01 mm yr(-1) for polar glaciers and thin temperate plateau glaciers on crystalline bedrock, to 0.1 mm yr(-1) for temperate valley glaciers also on resistant crystalline bedrock in Norway, to 1.0 mm yr(-1) for small temperate glaciers on diverse bedrock in the Swiss Alps, and to 10-100 mm yr(-1) for large and fast-moving temperate valley glaciers in the tectonically active ranges of southeast Alaska. In Alaska, current sediment yields generally increase with the extent of glacial ice cover, and are particularly high in the large heavily-glaciated basins of southern Alaska, where they exceed those of basins from other regions by about one order of magnitude, These results, supported by comparisons of sediment yields between glaciated and nonglaciated basins in Alaska, Norway and Iceland, suggest that climatic conditions favorable for the expansion of temperate valley glaciers tend to increase both mechanical and chemical denudation rates. The results are discussed in the broader context of linking erosion and climate during the ice ages of the Quaternary, and interpreting records of sedimentation from glaciated regions. C1 UNIV WASHINGTON,DEPT GEOL SCI,SEATTLE,WA 98195. USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. NORWEGIAN WATER RESOURCES & ENERGY ADM,HYDROL DEPT,N-0301 OSLO,NORWAY. RP Hallet, B (reprint author), UNIV WASHINGTON,QUATERNARY RES CTR,SEATTLE,WA 98195, USA. NR 86 TC 511 Z9 514 U1 12 U2 106 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0921-8181 J9 GLOBAL PLANET CHANGE JI Glob. Planet. Change PD MAR PY 1996 VL 12 IS 1-4 BP 213 EP 235 DI 10.1016/0921-8181(95)00021-6 PG 23 WC Geography, Physical; Geosciences, Multidisciplinary SC Physical Geography; Geology GA UP227 UT WOS:A1996UP22700014 ER PT J AU Hines, JF Khalifa, MA Moore, JL Fine, KP Lage, JM Barnes, WA AF Hines, JF Khalifa, MA Moore, JL Fine, KP Lage, JM Barnes, WA TI Recurrent granulosa cell tumor of the ovary 37 years after initial diagnosis: A case report and review of the literature SO GYNECOLOGIC ONCOLOGY LA English DT Article ID DNA CONTENT; CHEMOTHERAPY; CISPLATIN AB Granulosa cell tumors of the ovary (GCTs) are uncommon neoplasms that are characterized by late recurrence and high survival rates. A case of recurrent GCT presenting 37 years after initial diagnosis is reported with a review of the literature, This case illustrates an example of a very late recurrence and emphasizes the importance of the extended follow-up required for these patients. (C) 1996 Academic Press Inc. C1 GEORGETOWN UNIV,MED CTR,DEPT OBSTET & GYNECOL,LOMBARDI CANC CTR,DIV GYNECOL ONCOL,WASHINGTON,DC 20007. GEORGETOWN UNIV,MED CTR,DEPT PATHOL,WASHINGTON,DC 20007. MEM UNIV NEWFOUNDLAND,DISCIPLINE PATHOL,ST JOHN,NF A1B 3V6,CANADA. RP Hines, JF (reprint author), BROOKE ARMY MED CTR,DEPT OBSTET & GYNECOL,GYNECOL ONCOL SERV,FT SAM HOUSTON,TX 78234, USA. NR 33 TC 70 Z9 78 U1 0 U2 2 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD MAR PY 1996 VL 60 IS 3 BP 484 EP 488 DI 10.1006/gyno.1996.0078 PG 5 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA TY216 UT WOS:A1996TY21600028 PM 8774662 ER PT J AU Smith, JR Schlager, JJ AF Smith, JR Schlager, JJ TI Gas chromatographic separation of the stereoisomers of organophosphorus chemical warfare agents using cyclodextrin capillary columns SO HRC-JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY LA English DT Article DE gas chromatography; atomic emission spectroscopy; enantiomeric separation; cyclodextrins; chemical warfare agents ID 1,2,2-TRIMETHYLPROPYL METHYLPHOSPHONOFLUORIDATE SOMAN; 4 STEREOISOMERS; NERVE AGENTS; TABUN AB The synthesis of the organophosphorus nerve agents sarin, tabun, and cyclohexyl methylphosphonofluoridate (GF) produces a mixture of two stereoisomers except for soman where four stereoisomers are produced, Significant differences exist in the reported toxicity and AChE inhibition rates of the various stereoisomers, This makes the ability to distinguish between the different stereoisomers desirable, Five different derivatized cyclodextrin stationary phases developed for gas chromatography were tested for their ability to resolve the nerve agent stereoisomers using a gas chromatograph interfaced to an atomic emission detector, Of the five columns that we examined, only the 2,6-di-O-pentyl-3-O-trifluoroacetyl or 2,6-di-O-pentyl-3-O-butyryl gamma-cyclodextrins were able to successfully resolve all four soman stereoisomers. The elution order for each column was determined using solutions of isolated soman stereoisomers, Enantiomers of sarin, tabun, and GF were resolved with varying degrees of success on the different cyclodextrin stationary phases, Only the butyryl gamma-cyclodextrin was able to separate the enantiomers of all four of the nerve agents examined in this study, The capacity (k) and selectivity (a) factors were determined for each of the chemical warfare agents successfully separated, The TNO Prins Maurits Laboratory in the Netherlands has previously developed several different chromatographic methods to resolve the stereoisomers of soman, sarin, and tabun, The advantage of the method described here is that commercially available cyclodextrin gas chromatography columns were used to resolve the stereoisomers, thereby facilitating rapid and routine analysis of organophosphorus nerve agents. RP Smith, JR (reprint author), USA,MED RES INST CHEM DEF,APPL PHARMACOL BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. OI Smith, James/0000-0001-8805-3788 NR 12 TC 16 Z9 16 U1 1 U2 5 PU DR ALFRED HUTHIG VERLAG GMBH PI HEIDELBERG 1 PA POSTFACH 102869, W-69018 HEIDELBERG 1, GERMANY SN 0935-6304 J9 HRC-J HIGH RES CHROM JI HRC-J. High Resolut. Chromatogr. PD MAR PY 1996 VL 19 IS 3 BP 151 EP 154 PG 4 WC Chemistry, Analytical SC Chemistry GA UF870 UT WOS:A1996UF87000005 ER PT J AU Satava, RM Jones, SB AF Satava, RM Jones, SB TI An integrated medical virtual reality program SO IEEE ENGINEERING IN MEDICINE AND BIOLOGY MAGAZINE LA English DT Article C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 6 TC 1 Z9 3 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0739-5175 J9 IEEE ENG MED BIOL JI IEEE Eng. Med. Biol. Mag. PD MAR-APR PY 1996 VL 15 IS 2 BP 94 EP & DI 10.1109/51.486724 PG 5 WC Engineering, Biomedical; Medical Informatics SC Engineering; Medical Informatics GA UA181 UT WOS:A1996UA18100017 ER PT J AU ONeill, K Lussky, RF Paulsen, KD AF ONeill, K Lussky, RF Paulsen, KD TI Scattering from a metallic object embedded near the randomly rough surface of a lossy dielectric SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article ID ELECTROMAGNETIC INVERSE-SCATTERING; INFINITE HALF-SPACES; PLANAR INTERFACE; TE EXCITATION; CYLINDERS AB Two-dimensional electromagnetic scattering from a perfectly conducting target embedded near the randomly rough surface of an isotropic lossy dielectric is investigated. The randomly rough surface is illuminated by a finite width beam from an antenna in the free space above the surface, with off-normal incidence, Standard integral equation methods are applied and include all subsurface interactions between the object and rough surface. For a chosen embedded target, Monte Carlo simulations are performed for a selection of ensembles of rough surface types intended to be suggestive of natural ground. Far field scattering coefficient distributions and corresponding synthetic images suggest when the buried object should be discernible. Sensitivities are explored in terms of surface type, polarization of the incident field, depth and orientation of target, soil characteristics, incidence angle, and beamwidth. Many of the scattering features identified should also apply in 3-D. C1 DARTMOUTH COLL,THAYER SCH ENGN,HANOVER,NH 03755. RP ONeill, K (reprint author), COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 19 TC 38 Z9 39 U1 0 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD MAR PY 1996 VL 34 IS 2 BP 367 EP 376 DI 10.1109/36.485114 PG 10 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA UC326 UT WOS:A1996UC32600007 ER PT J AU Newkirk, MH Brown, GS AF Newkirk, MH Brown, GS TI A waveform model for surface and volume scattering from ice and snow SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article ID IMPULSE-RESPONSE AB A method for combining surface and volume scattering effects to model the radar altimeter power waveforms recorded over continental ice and snow, such as that present on Greenland and Antarctica, is discussed. The surface model that is used is a variant of the well-known impulse response based method that is capable of modeling the returns for an altimeter having a general configuration of altitude, antenna beamwidth, transmitted pulsewidth, and pointing angle. The newly formulated volume model is also an impulse response based method that differs from previously introduced versions in that it can also be applied to a general altimeter configuration. The two models are added together assuming completely incoherent scattering. An example of fitting this combined model to altimeter data is given to illustrate the importance of accounting for the volume scattering present in ice/snow data. An optimization method can then be used to achieve a least-squares fit to actual altimeter data, providing an estimate of the parameters for that area on the ice shelf. C1 VIRGINIA POLYTECH INST & STATE UNIV,BRADLEY DEPT ELECT ENGN,BLACKSBURG,VA 24061. RP Newkirk, MH (reprint author), USA,RES LAB,ADELPHI,MD 20783, USA. NR 15 TC 8 Z9 8 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD MAR PY 1996 VL 34 IS 2 BP 444 EP 456 DI 10.1109/36.485122 PG 13 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA UC326 UT WOS:A1996UC32600015 ER PT J AU Hughes, BL Cooper, AB AF Hughes, BL Cooper, AB TI Nearly optimal multiuser codes for the binary adder channel SO IEEE TRANSACTIONS ON INFORMATION THEORY LA English DT Article DE multiaccess communication; multiuser coding; binary adder channel; capacity region; zero-error capacity ID MULTIPLE-ACCESS; FEEDBACK; USERS AB Coding schemes for the T-user binary adder channel are investigated, Recursive constructions are given for two families of mixed-rate, multiuser codes, It is shown that these basic codes can be combined by time-sharing to yield codes approaching most rates in the T-user capacity region, In particular, the best codes constructed herein achieve a sum-rate, R(1) +...+ R(T), which is higher than all previously reported codes for almost every T and is within 0.547-bit-per-channel use of the information-theoretic limit. Extensions to a T-user, Q-frequency adder channel are also discussed. C1 USA,RES LAB,INFORMAT SCI & TECHNOL DIRECTORATE,ABERDEEN PROVING GROUND,MD 21005. RP Hughes, BL (reprint author), JOHNS HOPKINS UNIV,DEPT ELECT & COMP ENGN,BALTIMORE,MD 21218, USA. RI Cooper III, A. Brinton/A-3336-2010 NR 29 TC 14 Z9 14 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9448 J9 IEEE T INFORM THEORY JI IEEE Trans. Inf. Theory PD MAR PY 1996 VL 42 IS 2 BP 387 EP 398 DI 10.1109/18.485711 PG 12 WC Computer Science, Information Systems; Engineering, Electrical & Electronic SC Computer Science; Engineering GA UA147 UT WOS:A1996UA14700005 ER PT J AU Emerson, D Hakim, E Govind, A AF Emerson, D Hakim, E Govind, A TI Plastic-encapsulated microcircuit reliability & cost-effectiveness study SO IEEE TRANSACTIONS ON RELIABILITY LA English DT Article DE plastic-encapsulated microcircuit AB This study evaluates the reliability and cost-effectiveness of using commercial plastic-encapsulated microcircuits (PEM) in a typical military system, with a view to increasing their acceptability in military applications. The cost comparison indicates an average 6-fold decrease in cost when commercial devices are used. Assurance testing did not reveal any special problems with commercial parts. Thus, if commercial PEM were proven to be sufficiently reliable for an intended military application, large cost savings would be gained by using them instead of hermetic packages. The 4.5-sigma enhanced inspection program and the process-control methods suggested here would enhance the manufacturing yield of the PLGR (precision lightweight global positioning system receiver) by encouraging improvements in the manufacturing process while simultaneously cutting the cost of a 100% rescreen to qualify the final product. Neither the requirements assurance tests (including the step-stress test-analyze-and-fix test), nor the reliability demonstration test, nor the operational test, showed more failures than are typical for any new development, and no problems unique to PEM were observed. Thus, the use of PEM did not lead to any special problems that caused PLGR-use specifications to be violated. Complete failure analysis of the isolated parts is in progress, and the results will help to understand the specific reliability issues involved with the use of PEM in military systems. These issues can then be addressed to improve the acceptability of such devices in future military applications. C1 USA,RES LAB,COMPONENT RELIABIL BRANCH,FT MONMOUTH,NJ 07703. UNIV MARYLAND,CALCE,ELECTR PACKAGING RES CTR,COLLEGE PK,MD 20742. RP Emerson, D (reprint author), ROCKWELL INT CORP,CEDAR RAPIDS,IA, USA. NR 3 TC 2 Z9 2 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9529 J9 IEEE T RELIAB JI IEEE Trans. Reliab. PD MAR PY 1996 VL 45 IS 1 BP 19 EP 22 DI 10.1109/24.488910 PG 4 WC Computer Science, Hardware & Architecture; Computer Science, Software Engineering; Engineering, Electrical & Electronic SC Computer Science; Engineering GA UG993 UT WOS:A1996UG99300008 ER PT J AU Kosinski, JA Ballato, A Lu, YC AF Kosinski, JA Ballato, A Lu, YC TI A finite plate technique for the determination of piezoelectric material constants SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Article ID COUPLED THICKNESS SHEAR; RESONATORS; OVERTONES; TWIST AB This paper presents an improved resonator method for the determination of piezoelectric material constants, The improved method addresses a fundamental limitation of the measurement methods recommended in the current IEEE Standard on Piezoelectricity: the relations between vibrator response and material constants presented in this Standard are based upon the 1-D approximation of an essentially infinite hat plate with a uniform distribution of vibratory motion, The calculation or measurement of the effects due to the nonuniform vibrational amplitude distribution in a laterally bounded plate is a nontrivial task, The practical result is that the current IEEE 176-1987 resonator method recommendations are of limited usefulness in the determination of ''intrinsic'' piezoelectric material constants, This limitation can, however, readily be overcome using an improved measurement technique based on measurands unaffected by the vibrational amplitude distribution, In the improved technique, the measurands of choice are the zero-mass-loading, fundamental mode, thickness-field excitation (TE) antiresonance, or lateral-field excitation (LE) resonance frequencies, A recommended experimental procedure, using the preferred measurands, is presented. C1 RUTGERS STATE UNIV, DEPT ELECT & COMP ENGN, PISCATAWAY, NJ 08855 USA. RP Kosinski, JA (reprint author), USA, RES LAB, PHYS SCI DIRECTORATE, FT MONMOUTH, NJ 07703 USA. NR 16 TC 6 Z9 6 U1 0 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD MAR PY 1996 VL 43 IS 2 BP 280 EP 284 DI 10.1109/58.485954 PG 5 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA TX556 UT WOS:A1996TX55600009 ER PT J AU Fowler, BW AF Fowler, BW TI Research and development project selection - Martino,JP SO INTERFACES LA English DT Book Review RP Fowler, BW (reprint author), USA,MISSILE COMMAND,ADV SYST CONCEPTS OFF,REDSTONE ARSENAL,AL 35898, USA. NR 1 TC 0 Z9 0 U1 1 U2 2 PU INST OPERATIONS RESEARCH MANAGEMENT SCIENCES PI LINTHICUM HTS PA 901 ELKRIDGE LANDING RD, STE 400, LINTHICUM HTS, MD 21090-2909 SN 0092-2102 J9 INTERFACES JI Interfaces PD MAR-APR PY 1996 VL 26 IS 2 BP 117 EP 118 PG 2 WC Management; Operations Research & Management Science SC Business & Economics; Operations Research & Management Science GA UG792 UT WOS:A1996UG79200014 ER PT J AU Harrison, JK Chadwick, M Scales, M AF Harrison, JK Chadwick, M Scales, M TI The relationship between cross-cultural adjustment and the personality variables of self-efficacy and self-monitoring SO INTERNATIONAL JOURNAL OF INTERCULTURAL RELATIONS LA English DT Article ID OVERSEAS ASSIGNMENTS; MAIL SURVEYS; BEHAVIOR; SCALE; EXPECTATIONS; PERFORMANCE; PERCEPTIONS; DIMENSIONS; VALIDATION; VALIDITY AB A primary determinant of expatriates' effectiveness is how well they adjust their behavior to function appropriately within a host culture. Because research suggests that the adjustment process may be highly related to certain personality variables, this survey of 99 American expatriates in Europe focused on two such variables - self-efficacy and self-monitoring - both of which have received increasing attention in the domestic literature, but have not been investigated empirically in the international research on the multifacets of cultural adjustment. Results of the study indicated that subjects with high general self-efficacy expressed significantly greater degrees of general, interaction, and work adjustment than those with low general self-efficacy. Similar ly, high self-monitors expressed greater degrees of general and interaction adjustment than did low self-monitors. No significant difference, however, was found between high and low self-monitors on work adjustment. Given the overall positive results, these findings provide support for the consideration of these personality variables in expatriate selection and training. Copyright (C) 1996 Elsevier Science Ltd. C1 USA,WASHINGTON,DC. RP Harrison, JK (reprint author), WAKE FOREST UNIV,WINSTON SALEM,NC 27109, USA. RI enwei, xiang/F-7452-2013 NR 61 TC 67 Z9 67 U1 3 U2 14 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0147-1767 J9 INT J INTERCULT REL JI Int. J. Intercult. Relat. PD SPR PY 1996 VL 20 IS 2 BP 167 EP 188 DI 10.1016/0147-1767(95)00039-9 PG 22 WC Psychology, Social; Social Sciences, Interdisciplinary; Sociology SC Psychology; Social Sciences - Other Topics; Sociology GA VG626 UT WOS:A1996VG62600003 ER PT J AU Harper, MT Chandnani, VP Spaeth, J Santangelo, JR Providence, BC Bagg, MA AF Harper, MT Chandnani, VP Spaeth, J Santangelo, JR Providence, BC Bagg, MA TI Gamekeeper thumb: Diagnosis of ulnar collateral ligament injury using magnetic resonance imaging, magnetic resonance arthrography and stress radiography SO JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING LA English DT Article DE gamekeeper thumb; MR arthrography; ulnar collateral ligament ID TEARS AB Ulnar collateral ligament (UCL) tears may be nondisplaced or displaced relative to the adductor pollicis aponeurosis, Nondisplaced tears typically heal with immobilization whereas displaced tears require surgery. Nineteen patients with UCL injuries were evaluated using MR imaging (MRI), MR arthrography, and stress radiography (SR) to determine the efficacy of these techniques in differentiating nondisplaced from displaced UCL tears, Nineteen patients with UCL injuries were evaluated. MRI was utilized in 5 patients, and MR arthrography in 14, with 12 of these 14 undergoing SR. They were followed until resolution of symptoms; those without relief, and those with suspected displaced UCL tears were surgically explored. Surgery and imaging was correlated, Eight patients underwent surgical repair. SR was abnormal in six patients treated surgically, but was negative in four of six conservatively treated patients with MR findings of nondisplaced tears, All patients with MR or MR arthrographic findings interpreted as being normal or as having a nondisplaced tear improved after conservative treatment, Based on surgical findings and clinical follow-up, NIR arthrography accurately diagnosed 13 of 14 UCL injuries, with one false-positive interpretation. SR is often falsely negative, MR imaging with or without intra-articular contrast injection proved to be accurate in a small series of patients with UCL injuries. RP Harper, MT (reprint author), TRIPLER ARMY MED CTR,HSHK DR,DEPT RADIOL,HONOLULU,HI 96859, USA. NR 26 TC 25 Z9 25 U1 0 U2 0 PU SOC MAGNETIC RESONANCE IMAGING PI EASTON PA 1991 NORTHAMPTON ST, EASTON, PA 18042-3189 SN 1053-1807 J9 JMRI-J MAGN RESON IM JI JMRI-J. Magn. Reson. Imaging PD MAR-APR PY 1996 VL 6 IS 2 BP 322 EP 328 DI 10.1002/jmri.1880060211 PG 7 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA UG275 UT WOS:A1996UG27500010 PM 9132097 ER PT J AU Reuss, M AF Reuss, M TI River of promise, river of peril: The politics of managing the Missouri River - Thorson,JE SO JOURNAL OF AMERICAN HISTORY LA English DT Book Review RP Reuss, M (reprint author), USA CORPS ENGINEERS,ALEXANDRIA,VA, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ORGAN AMER HISTORIANS PI BLOOMINGTON PA 112 N BRYAN ST, BLOOMINGTON, IN 47401 SN 0021-8723 J9 J AM HIST JI J. Am. Hist. PD MAR PY 1996 VL 82 IS 4 BP 1641 EP 1642 DI 10.2307/2945430 PG 2 WC History SC History GA UC106 UT WOS:A1996UC10600135 ER PT J AU Muza, SR Criner, GJ Kelsen, SG AF Muza, SR Criner, GJ Kelsen, SG TI Effect of lung volume on the respiratory action of the canine sternomastoid SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE respiratory muscles; posture; neck muscles; intrathoracic pressure ID INTERCOSTAL MUSCLES; DIAPHRAGM; MECHANICS; DOGS AB We tested the hypothesis that because the resting length of the canine sternomastoid (SM) muscles is relatively insensitive to lung volume change, the SM may maintain its inspiratory force generation regardless of lung volume. The relationships between SM pre- and postcontraction in situ fiber lengths and SM-produced inspiratory pressure generation [i.e., esophageal (Pes)] and rib cage displacements were examined in adult supine anesthetized dogs at residual volume (RV), functional residual capacity, and total lung capacity. SM muscle contraction was produced by isolated bilateral supramaximal electrical stimulation during hyperventilation-induced apnea. In all animals, Sill contraction produced negative change in Pes (i.e., an inspiratory action). Passively increasing lung volume from RV to total lung capacity decreased (P less than or equal to 0.01) the SM-produced Pes by -66 +/- 4% but had a relatively small effect on SM in situ pre- and postcontraction fiber length (<3%). Whereas SM contraction at RV produced a cranial displacement of the sternum and increased the upper rib cage cross-sectional area, passively elevating lung volume diminished the SM-produced expansion of the upper rib cage. Hyperinflation did not increase the impedance of the sternum to cranial displacement during SM contraction, suggesting that hyperinflation caused a dissociation between the mechanical action of the sternum and the upper rib cage. These results suggest that mechanical dissociation of the ribs and sternum may diminish the contribution of the SM to inspiratory volume generation when breathing is done from elevated end-expiratory lung volumes. C1 TEMPLE UNIV,SCH MED,DEPT MED,PHILADELPHIA,PA 19140. TEMPLE UNIV,SCH MED,DEPT PHYSIOL,PHILADELPHIA,PA 19140. RP Muza, SR (reprint author), USA,ENVIRONM MED RES INST,KANSAS ST,NATICK,MA 01760, USA. FU NHLBI NIH HHS [HL-1-RO1-HL-40295-04] NR 13 TC 2 Z9 2 U1 1 U2 1 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD MAR PY 1996 VL 80 IS 3 BP 852 EP 856 PG 5 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA UE825 UT WOS:A1996UE82500021 PM 8964747 ER PT J AU WhiteWelkley, JE Warren, GL Bunnell, BN Mougey, EH Meyerhoff, JL Dishman, RK AF WhiteWelkley, JE Warren, GL Bunnell, BN Mougey, EH Meyerhoff, JL Dishman, RK TI Treadmill exercise training and estradiol increase plasma ACTH and prolactin after novel footshock SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE footshock; immobilization; hypothalamic-pituitary-adrenal cortical; hypothalamic-pituitary-gonadal; ovariectomized; adrenocorticotropic hormone ID CORTICOTROPIN-RELEASING FACTOR; PITUITARY CYCLIC-AMP; FEMALE RATS; ADRENOCORTICOTROPIN RESPONSE; ANTERIOR-PITUITARY; STRESS RESPONSE; BETA-ENDORPHIN; WOMEN RUNNERS; CORTICOSTERONE; SECRETION AB We examined whether rats that were treadmill exercise trained (Tr) or chronically immobilized (CI) had similar responses by the hypothalamic-pituitary-adrenal (HPA) cortical axis to acute stress and whether the HPA responses interacted with the hypothalamic-pituitary-gonadal (HPG) axis. After 6 wk (1 h/day, 6 days/wk) of Tr or CI, plasma concentrations of adrenocorticotropic hormone ([ACTH]), [prolactin], and [corticosterone] were measured after familiar (treadmill running or immobilization) or novel (footshock) stress. Ovariectomized Sprague-Dawley females (n = 72) were implanted with capsules containing estradiol benzoate (E(2)) and randomly assigned in a 2-group (E(2) vs. no E(2)) x 3 treatment (Tr vs. CI vs. sedentary) x 4 acute stressor [footshock vs. treadmill running (Run) vs. immobilization (Im) vs. no stress] x 3 recovery time (1 vs. 15 vs. 30 min) mixed-model analysis of variance. E(2) capsules were removed from one-half of the animals 48 h before the first stressor session. After 10 min of acute stress, blood was drawn from a jugular catheter at 1, 15, and 30 min of recovery. [ACTH] and [prolactin] after footshock were higher in Tr rats with E(2) compared with CI and sedentary rats without E(2); recovery levels for sedentary animals were higher after Run compared with Im. The elevation in [corticosterone] from minute 1 to 15 of recovery was higher after the familiar Run and Im conditions. Our findings are consistent with an increased responsiveness of the HPA axis to novel footshock after treadmill exercise training that is additionally modulated by the HPG axis. C1 UNIV GEORGIA,DEPT EXERCISE SCI,ATHENS,GA 30602. UNIV GEORGIA,DEPT PSYCHOL,ATHENS,GA 30602. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT MED NEUROSCI,WASHINGTON,DC 20307. RI Warren, Gordon/A-9794-2008 OI Warren, Gordon/0000-0002-7073-8524 NR 56 TC 27 Z9 27 U1 1 U2 1 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD MAR PY 1996 VL 80 IS 3 BP 931 EP 939 PG 9 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA UE825 UT WOS:A1996UE82500033 PM 8964759 ER PT J AU Lieske, CN Clark, CR Zoeffel, LD vonTersch, RL Lowe, JR Smith, CD Broomfield, CA Baskin, SI Maxwell, DM AF Lieske, CN Clark, CR Zoeffel, LD vonTersch, RL Lowe, JR Smith, CD Broomfield, CA Baskin, SI Maxwell, DM TI Temperature effects in cyanolysis using elemental sulfur SO JOURNAL OF APPLIED TOXICOLOGY LA English DT Article DE cyanolysis; sulfur; albumin; temperature; kinetics ID SERUM-ALBUMIN AB As part of our studies directed at new treatments for cyanide poisoning we examined the effect of temperature on both the non-catalyzed and the albumin-catalyzed reactions of cyanide with a colloidal suspension of elemental sulfur (CSES). Using saturated sulfur solutions prepared in two solvents, pyridine (PY) and methyl cellosolve (MC), the reactions were studied at 15.0, 25.0, 30.0 and 37.5 degrees C. For all the cyanolysis reactions (non-catalyzed and albumin-catalyzed) there is an enhancement of reaction rate when the organic solvent for the sulfur is MC. Irrespective of the solvent for the CSES, the non-catalyzed reactions gave linear Arrhenius plots (PY, correlation coefficient = 0.998; MC, correlation coefficient = 0.997). In each case the entropy of activation was positive (14.1 cal K-1 mol(-1) for PY and 56.4 cal K-1 mol(-1) for MC). In contrast with these results the albumin-catalyzed reactions generated non-linear Arrhenius plots and negative entropies of activation. Non-linear plots were observed with the three albumins studied: human serum albumin, heat-shock bovine serum albumin and fatty acid-free bovine serum albumin. The non-linear plots are the result of a more complex reaction sequence than a simple cyanolysis reaction. C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. PROGRAMMING CONSULTANTS,BRADDOCK HTS,MD 21714. NR 24 TC 6 Z9 7 U1 1 U2 1 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0260-437X J9 J APPL TOXICOL JI J. Appl. Toxicol. PD MAR-APR PY 1996 VL 16 IS 2 BP 171 EP 175 DI 10.1002/(SICI)1099-1263(199603)16:2<171::AID-JAT327>3.3.CO;2-I PG 5 WC Toxicology SC Toxicology GA UF514 UT WOS:A1996UF51400014 PM 8935794 ER PT J AU Kim, HJ AF Kim, HJ TI Learning chemistry through numbers SO JOURNAL OF CHEMICAL EDUCATION LA English DT Article C1 USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0021-9584 J9 J CHEM EDUC JI J. Chem. Educ. PD MAR PY 1996 VL 73 IS 3 BP 236 EP 236 PG 1 WC Chemistry, Multidisciplinary; Education, Scientific Disciplines SC Chemistry; Education & Educational Research GA UB258 UT WOS:A1996UB25800018 ER PT J AU Dong, QH BruckerDavis, F Weintraub, BD Smallridge, RC Carr, FE Battey, J Spiegel, AM Shenker, A AF Dong, QH BruckerDavis, F Weintraub, BD Smallridge, RC Carr, FE Battey, J Spiegel, AM Shenker, A TI Screening of candidate oncogenes in human thyrotroph tumors: Absence of activating mutations of the G alpha(q), G alpha(11), G alpha(s), or thyrotropin-releasing hormone receptor genes SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM LA English DT Article ID PROTEIN-KINASE-C; SECRETING PITUITARY-ADENOMAS; HUMAN ENDOCRINE TUMORS; NIH 3T3 CELLS; G-ALPHA-Q; PHOSPHOLIPASE-C; ADENYLYL CYCLASE; MALIGNANT TRANSFORMATION; PRIMARY HYPOTHYROIDISM; REGULATORY PROTEINS AB Activating mutations encoding substitutions at positions Arg(201) and Gln(227) of the alpha-subunit of the stimulatory C protein, G(s), have been found in about 40% of pituitary somatotroph tumors. Although the etiology of thyrotroph adenomas is unknown, their autonomous behavior and blunted response to stimulatory hypothalamic hormone superficially resemble those of somatotroph tumors. We hypothesized that a subset of thyrotroph tumors might be caused by dominant somatic mutations that lead to inappropriate activation of the G(q)/phospholipase C beta/Ca2+/protein kinase C pathway normally triggered by occupancy of the TRH receptor (TRHR). We, therefore, screened samples from nine thyrotroph tumors for the presence of activating mutations of the alpha(q), alpha(11), and TRHR genes. Fragments of alpha(q) and alpha(11) complementary DNA encompassing residues (Arg(183) and Gln(209)) that correspond to Arg(201) and Gln(227) of alpha(s) were amplified and sequenced. Temperature gradient gel electrophoresis was used to screen for heterozygous mutations in the TRHR coding sequence as well as for known alpha(s) mutations. No mutations were detected. We conclude that mutations in these regions of the alpha(q), alpha(11), alpha(s), and TRHR genes occur infrequently, if at all, in human thyrotroph tumors. Alternative mechanisms underlying thyrotroph tumorigenesis, including changes in the expression levels of G protein alpha-subunits or TRHR, dysregulation of downstream components, inappropriate activation of other stimulatory pathways, or loss of inhibitory inputs, remain to be explored. C1 NIDDKD, MOLEC & CELLULAR ENDOCRINOL BRANCH, NATL INST DEAFNESS & OTHER COMMUN DISORDERS, BETHESDA, MD 20892 USA. NIDDKD, METAB DIS BRANCH, NATL INST DEAFNESS & OTHER COMMUN DISORDERS, NATL INST HLTH, BETHESDA, MD 20892 USA. WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, DIV MED, WASHINGTON, DC 20307 USA. WALTER REED ARMY MED CTR, DEPT CLIN INVEST, WASHINGTON, DC 20307 USA. NR 69 TC 48 Z9 49 U1 0 U2 1 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0021-972X EI 1945-7197 J9 J CLIN ENDOCR METAB JI J. Clin. Endocrinol. Metab. PD MAR PY 1996 VL 81 IS 3 BP 1134 EP 1140 DI 10.1210/jc.81.3.1134 PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA TZ906 UT WOS:A1996TZ90600048 PM 8772588 ER PT J AU Abbott, K Smith, A Bakris, GL AF Abbott, K Smith, A Bakris, GL TI Effects of dihydropyridine calcium antagonists on albuminuria in patients with diabetes SO JOURNAL OF CLINICAL PHARMACOLOGY LA English DT Article ID CONVERTING ENZYME-INHIBITION; NEPHROPATHY; CAPTOPRIL; NIFEDIPINE AB The present study was designed to assess the effects of two different dyhydropyridine calcium antagonists (DHPCAs) on proteinuria in patients with noninsulin-dependent diabetes mellitus (NIDDM). The hypothesis that similar levels of blood pressure reduction with two different DHPCAs produce similar degrees of proteinuria reduction was tested. In a prospective randomized study, 14 patients with NIDDM, hypertension, proteinuria, and renal insufficiency were given either isradipine (n = 7) or nifedipine XL (n = 7) for 6 months. After a 2-week washout period, patients were crossed over to the other drug and observed for an additional 6 months. Drugs were titrated to lower arterial pressure to <140/90 mmHg. Patients also instructed to follow a low-sodium diet at the initial visit. Blood pressure and 24-hour urine values for creatinine clearance, albuminuria, proteinuria, and sodium were assessed monthly. At the end of the initial and crossover treatment periods, there were no significant reductions in the level of albuminuria from baseline with either drug. Sodium excretion was <110 mEq/L with each drug tested. The results of this study support the concept that DHPCAs do not reduce proteinuria in patients with type II diabetes. This failure to reduce albuminuria and proteinuria occurred despite adequate blood pressure reduction and an effort at dietary sodium restriction. C1 RUSH UNIV,HYPERTENS CTR,RUSH PRESBYTERIAN ST LUKES MED CTR,DEPT PREVENT MED,CHICAGO,IL 60612. BROOKE ARMY MED CTR,DEPT MED,DIV NEPHROL,SAN ANTONIO,TX. RUSH UNIV,HYPERTENS CTR,RUSH PRESBYTERIAN ST LUKES MED CTR,DEPT INTERNAL MED,CHICAGO,IL 60612. OI Abbott, Kevin/0000-0003-2111-7112 NR 25 TC 23 Z9 23 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0091-2700 J9 J CLIN PHARMACOL JI J. Clin. Pharmacol. PD MAR PY 1996 VL 36 IS 3 BP 274 EP 279 PG 6 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA UC842 UT WOS:A1996UC84200014 PM 8690823 ER PT J AU Fucella, JE Dolan, R AF Fucella, JE Dolan, R TI Magnitude of subaerial beach disturbance during northeast storms SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE shore processes; waves; storm magnitude; beach erosion; shore profile ID SAND AB Analysis of simultaneous measurements of inshore processes and changes in beach profiles over a nine-month period on the Outer Banks of North Carolina shows a relationship between storm magnitude and the vertical and horizontal erosion of a subaerial beach. The maximum cut during any tidal cycle was 70 cm, which occurred in the middle of the profile. The majority of the erosion occurring during the first 6 hours Of the storms and approximately 50 percent of the sand lost during the storms was recovered within the first 12 hours following the storms. wave height and steepness and the pre-storm beach configuration determined the extent of the vertical erosion. There is a downward limit to vertical erosion, and once this level is reached the maximum changes become horizontal. C1 UNIV VIRGINIA,DEPT ENVIRONM SCI,CHARLOTTESVILLE,VA 22903. RP Fucella, JE (reprint author), US MIL ACAD,DEPT GEOG & ENVIRONM ENGN,W POINT,NY 10996, USA. NR 22 TC 26 Z9 26 U1 0 U2 0 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD SPR PY 1996 VL 12 IS 2 BP 420 EP 429 PG 10 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA UH417 UT WOS:A1996UH41700003 ER PT J AU Tuthill, AM Wuebben, JL Daly, SF White, KD AF Tuthill, AM Wuebben, JL Daly, SF White, KD TI Probability distributions for peak stage on rivers affected by ice jams SO JOURNAL OF COLD REGIONS ENGINEERING LA English DT Article AB Evaluation of alternatives to reduce the severity of ice-jam flooding requires the development of probability distributions for ice-affected stage at non-gauged locations along a river reach. Difficulties arise as the ice-affected peak stage is not only a function of discharge and channel hydraulic properties, as is the case for the open water period, but is also influenced by the location, extent, thickness, and roughness of ice jams. This paper presents a new method for estimating winter peak stage along a river reach by dividing the record of winter peak discharges into distinct ice-jam and no-ice-jam populations. Rating curves may then be developed for each population using gradually varied-flow analysis and existing equilibrium ice-jam theory. Stage-probability distributions for the ice jam and no-ice-jam populations may then be combined into a single stage-frequency relationship representing the entire winter period. A case study is presented, in which the method is used to develop probability distributions for the annual maximum stage along the Winooski River at Montpelier, Vt. Viewed in the context of the historical record, the method yields reasonable results. RP Tuthill, AM (reprint author), COLD REG ENGN LAB,72 LYME RD,HANOVER,NH 03766, USA. NR 18 TC 17 Z9 17 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0887-381X J9 J COLD REG ENG JI J. Cold Reg. Eng. PD MAR PY 1996 VL 10 IS 1 BP 36 EP 57 DI 10.1061/(ASCE)0887-381X(1996)10:1(36) PG 22 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA TY005 UT WOS:A1996TY00500004 ER PT J AU Pamulapati, J Bhattacharya, PK Singh, J Berger, PR Snyder, CW Orr, BG Tober, RL AF Pamulapati, J Bhattacharya, PK Singh, J Berger, PR Snyder, CW Orr, BG Tober, RL TI Realization of in-situ sub two-dimensional quantum structures by strained layer growth phenomena in the InxGa1-xAs/GaAs system SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE InGaAs/GaAs; reflection high energy electron diffraction (RHEED); scanning tunneling microscopy (STM); strained layer growth ID MOLECULAR-BEAM EPITAXY; SURFACES; GAAS AB We confirm that as the misfit strain in pseudomorphic epitaxial layer increases, surface thermodynamics controlled growth modes can change from a layer-by-layer to a three-dimensional (3-D) island mode. Both in-situ reflection high energy electron diffraction studies and in-situ scanning tunneling microscopy studies are utilized to demonstrate this transition to 3-D growth. This concept allows one to grow GaAs/InxGa1-xAs/GaAs heterostructures where the electrons in InxGa1-xAs are possibly confined in lower dimensions. C1 UNIV MICHIGAN,DEPT ELECT ENGN & COMP SCI,SOLID STATE ELECTR LAB,ANN ARBOR,MI 48109. UNIV MICHIGAN,HARRISON M RANDALL LAB PHYS,ANN ARBOR,MI 48109. USA,RES LABS,ADELPHI,MD 20783. RI Berger, Paul/I-4063-2014 OI Berger, Paul/0000-0002-2656-2349 NR 15 TC 9 Z9 9 U1 0 U2 3 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 420 COMMONWEALTH DR, WARRENDALE, PA 15086 SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD MAR PY 1996 VL 25 IS 3 BP 479 EP 483 DI 10.1007/BF02666623 PG 5 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA TY346 UT WOS:A1996TY34600029 ER PT J AU Gold, VM Vradis, GC Pearson, JC AF Gold, VM Vradis, GC Pearson, JC TI Constitutive models for concrete penetration analysis SO JOURNAL OF ENGINEERING MECHANICS-ASCE LA English DT Article AB Three-dimensional axisymmetric calculations of penetration of concrete targets have been conducted with the GALE (Arbitrary Lagrangian Eulerian) code. All the constitutive models studied accounted for the compressibility of concrete and employed either solid or porous equation of state models; the influence of these models on the penetration calculations is studied and presented. The size of the plastic zone in front of the penetrator is estimated from the calculations for both compressibility models and is compared with the available experimental data. Comparison between the calculated values of the extent of this zone and the experimental data indicates that the porous equation of state model is more realistic in representing the elastic-plastic deformation in concrete. Effects of the initial porosity of concrete on penetration calculations are also studied and discussed. The application of constant yield-strength and pressure-dependent yield-strength models for the concrete penetration analysis is studied, and the results of the calculations are presented and discussed. Crater profiles calculated with the pressure-dependent yield model showed good agreement with the available experimental penetration depths and the profiles of the tunnel portion of the crater. C1 POLYTECH UNIV,METROTECH CTR 6,DEPT ENGN MECH,BROOKLYN,NY 11201. RP Gold, VM (reprint author), USA,ARDEC,DIV ENERGET & WARHEADS,PICATINNY ARSENAL,NJ 07806, USA. NR 16 TC 1 Z9 3 U1 0 U2 2 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9399 J9 J ENG MECH-ASCE JI J. Eng. Mech.-ASCE PD MAR PY 1996 VL 122 IS 3 BP 230 EP 238 DI 10.1061/(ASCE)0733-9399(1996)122:3(230) PG 9 WC Engineering, Mechanical SC Engineering GA TX575 UT WOS:A1996TX57500006 ER PT J AU Bazant, ZP Xiang, YY Adley, MD Prat, PC Akers, SA AF Bazant, ZP Xiang, YY Adley, MD Prat, PC Akers, SA TI Microplane model for concrete .2. Data delocalization and verification SO JOURNAL OF ENGINEERING MECHANICS-ASCE LA English DT Article ID FAILURE AB The new microplane model developed in the preceding companion paper is calibrated and verified by comparison with test data. A new approximate method is proposed for data delocalization, i.e., decontamination of laboratory test data afflicted by localization of strain-softening damage and size effect. This method, applicable more generally to any type of constitutive model, is based on the series-coupling model and on the size-effect law proposed by Bazant. An effective and simplified method of material parameter identification, exploiting affinity transformations of stress-strain curves, is also given. Only five parameters need to be adjusted if a complete set of uniaxial, biaxial, and triaxial test data is available, and two of them can be determined separately in advance from the volumetric compression curve. If the data are limited, fewer parameters need to be adjusted. The parameters are formulated in such a manner that two of them represent scaling by affinity transformation. Normally only these two parameters need to be adjusted, which can be done by simple closed-form formulas. The new model allows good fit of all the basic types of uniaxial, biaxial, and triaxial test data for concrete. C1 USA,ENGR WTRWY EXPT STN,VICKSBURG,MS. RP Bazant, ZP (reprint author), NORTHWESTERN UNIV,EVANSTON,IL 60208, USA. RI Bazant, Zdenek/B-6743-2009 NR 28 TC 51 Z9 58 U1 0 U2 10 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9399 J9 J ENG MECH-ASCE JI J. Eng. Mech.-ASCE PD MAR PY 1996 VL 122 IS 3 BP 255 EP 262 PG 8 WC Engineering, Mechanical SC Engineering GA TX575 UT WOS:A1996TX57500009 ER PT J AU Malinowski, JC Thurber, CA AF Malinowski, JC Thurber, CA TI Developmental shifts in the place preferences of boys aged 8-16 years SO JOURNAL OF ENVIRONMENTAL PSYCHOLOGY LA English DT Article ID ACQUISITION; ROUTE; KNOWLEDGE AB Little is known about how and why children's preferences for different places changes as they get older. This study is a preliminary examination of developmental shifts in boys' place preferences. Boys aged 8 to 16 years (n=155) attending a residential summer camp were asked to indicate their favorite place in the camp and why they liked that place. The responses were categorized using a four-part classification scheme (land use, social, commercial and aesthetic/cognitive). Younger boys tended to choose places valued for a particular land use, while older boys tended to choose places for their aesthetic or cognitive qualities. A new developmental model of place preferences in boys is discussed. (C) 1996 Academic Press Limited C1 UNIV CALIF LOS ANGELES,DEPT PSYCHOL,LOS ANGELES,CA 90024. RP Malinowski, JC (reprint author), US MIL ACAD,DEPT GEOG & ENVIRONM ENGN,W POINT,NY 10996, USA. NR 32 TC 14 Z9 14 U1 0 U2 0 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0272-4944 J9 J ENVIRON PSYCHOL JI J. Environ. Psychol. PD MAR PY 1996 VL 16 IS 1 BP 45 EP 54 DI 10.1006/jevp.1996.0004 PG 10 WC Environmental Studies; Psychology, Multidisciplinary SC Environmental Sciences & Ecology; Psychology GA UL421 UT WOS:A1996UL42100004 ER PT J AU Angus, CW Tu, A Vogel, P Qin, M Kovacs, JA AF Angus, CW Tu, A Vogel, P Qin, M Kovacs, JA TI Expression of variants of the major surface glycoprotein of Pneumocystis carinii SO JOURNAL OF EXPERIMENTAL MEDICINE LA English DT Article ID ANTIGEN; PURIFICATION; ATTACHMENT; PNEUMONIA; PROTEIN; CELLS AB Previously, we have shown that a multicopy family of related but unique genes encodes the major surface glycoprotein (MSG) of Pneumocystis carinii. To examine whether different members of this gene family are expressed by P. carinii, antisera were prepared against peptides whose sequences were determined from the deduced amino acid sequences of variants of rat-derived MSG. Immunohistochemical staining of serial sections of rat lungs of infected infected animals showed that at least three variants of MSG were expressed in an individual lobe, that there was a focal expression of these variants within the lung, and that the relative numbers of these foci were different. Indirect immunofluorescent staining of purified P. carinii organisms using these antisera revealed that at least three variants of MSG were present in organisms isolated from an individual rat and that both cysts and trophozoites reacted with each antiserum. A substantial difference in the fraction of organisms reacting with a specific antipeptide antiserum was seen when comparing organisms isolated from rats raised in a single colony over a period of two years as well as organisms isolated at one time point from rats raised in different colonies. This demonstration of antigenic variation in P. carinii supports the hypothesis that P. carinii utilizes such variation for evading host defense mechanisms. C1 USA,MED RES INST INFECT DIS,DIV PATHOL,FREDERICK,MD 21702. RP Angus, CW (reprint author), NIH,DEPT CRIT CARE MED,CTR CLIN,BLDG 10,ROOM 7D43,MSC 1662,BETHESDA,MD 20892, USA. NR 27 TC 42 Z9 42 U1 0 U2 0 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 222 E 70TH STREET, NEW YORK, NY 10021 SN 0022-1007 J9 J EXP MED JI J. Exp. Med. PD MAR 1 PY 1996 VL 183 IS 3 BP 1229 EP 1234 DI 10.1084/jem.183.3.1229 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA UC775 UT WOS:A1996UC77500054 PM 8642264 ER PT J AU McClean, MD AF McClean, MD TI Lip-muscle reflexes during speech movement preparation in stutterers SO JOURNAL OF FLUENCY DISORDERS LA English DT Article ID TASK AB Neural processes underlying speech initiation may involve reduction in the excitability of sensory input from mechanoreceptors that mediate speech movements. It is suggested that this reduced excitability is not as great in individuals who stutter. The present experiment was intended to test this hypothesis by analyzing lip-muscle reflexes prior to speech initiation in stutterers and comparing these data to those obtained in an earlier study with nonstutterers (McClean & Clay, 1994), Mechanically evoked reflexes were studied in 14 adult stutterers prior to production of monosyllabic words beginning with the consonant p, The first component of the lip-muscle reflexes (R1) was quantified in terms of percent modulation of mean response levels of upper- and lower-lip EMG relative to reflexes elicited during no-response trials. In the previous study, 11 of IS nonstutterers showed significant attenuation of R1 across the upper and lower lip recording sites. In contrast, significant R1 attenuation was observed in only 4 of 14 stutterers tested here. As a group, stutterers showed less R1 attenuation prior to fluent speech at the lower-lip recording site compared to the nonstutterers. Reflex modulation associated with disfluent speech was quantified in three stutterers. Two showed marked increases in relative magnitude of R1 prior to disfluent compared to fluent speech trials, Based on these various results, it is suggested that reduced attenuation of mechanoreceptor input at the time of speech-movement initiation contributes to speech disfluency. RP McClean, MD (reprint author), WALTER REED ARMY MED CTR,AUDIOL & SPEECH CTR,WASHINGTON,DC 20307, USA. NR 14 TC 9 Z9 10 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0094-730X J9 J FLUENCY DISORD JI J. Fluency Disord. PD MAR PY 1996 VL 21 IS 1 BP 49 EP 60 DI 10.1016/0094-730X(95)00058-F PG 12 WC Audiology & Speech-Language Pathology; Education, Special; Linguistics; Rehabilitation SC Audiology & Speech-Language Pathology; Education & Educational Research; Linguistics; Rehabilitation GA TZ739 UT WOS:A1996TZ73900003 ER PT J AU Kim, HJ Choi, YM Yang, APP Yang, TCS Taub, IA Giles, J Ditusa, C Chall, S Zoltai, P AF Kim, HJ Choi, YM Yang, APP Yang, TCS Taub, IA Giles, J Ditusa, C Chall, S Zoltai, P TI Microbiological and chemical investigation of ohmic heating of particulate foods using a 5 kW ohmic system SO JOURNAL OF FOOD PROCESSING AND PRESERVATION LA English DT Article ID CONDUCTIVITY AB Lethality within food particles undergoing ohmic heating was investigated using microbiological and chemical marker measurements. Meatballs containing spores of B. stearothermophilus and precursors of chemical markers were thermally processed in a starch solution with 30-40% solids content using a 5 kilowatt (kW) ohmic system. Different temperatures, flow rates, holding tube lengths, and fluid electrical conductivities were used. Lethalities observed under various processing conditions were consistent with predictions. Higher lethality was observed, microbiologically and chemically, at the center of the meatballs rather than near the surface. A good correlation between the marker yield and the bacterial survivor population was obtained under various processing conditions. The results indicate that the chemical markers may be used to evaluate the distribution of lethality among different particles and the contribution to lethality of different holding sections. The results also suggest that sterility of ohmically heated particulate foods may be evaluated, to a first approximation, based on the fluid temperature and the residence time (i.e., holding tube geometry/flow rate). RP Kim, HJ (reprint author), USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760, USA. RI DiTusa, Charles/A-9143-2011 NR 23 TC 18 Z9 18 U1 0 U2 1 PU FOOD NUTRITION PRESS INC PI TRUMBULL PA 6527 MAIN ST, P O BOX 374, TRUMBULL, CT 06611 SN 0145-8892 J9 J FOOD PROCESS PRES JI J. Food Process Preserv. PD MAR PY 1996 VL 20 IS 1 BP 41 EP 58 DI 10.1111/j.1745-4549.1996.tb00339.x PG 18 WC Food Science & Technology SC Food Science & Technology GA UF902 UT WOS:A1996UF90200004 ER PT J AU Ebeling, RM Mosher, RL AF Ebeling, RM Mosher, RL TI Red River U-frame lock No 1 - Backfill-structure-foundation interaction SO JOURNAL OF GEOTECHNICAL ENGINEERING-ASCE LA English DT Article AB With a limited amount of data on soil properties and limited instrumentation readings, important aspects of lock performance from initial construction through major flood events, including siltation, were reasonably estimated using the backfill placement method of analysis. Results of the complete soil-structure-foundation interaction analyses for four operational load cases were essential to interpreting instrumentation measurements. Soil-structure interaction between the compacted sand backfill and the stem walls was distinguished from the interaction between the compacted sand backfill and the culvert walls. This study allowed for the characterization of the range in magnitudes and distributions (with elevation) of horizontal earth pressure coefficient, K-h, and vertical earth pressure coefficient, K-v, along the stem and culvert walls for each load case. Distributions of K-v with elevation have not been published to date. Expressing the effective normal pressure and vertical shear stress along lock walls in terms of the earth pressure coefficients, K-h and K-v, allowed for the precise recovery of both normal and shear stresses (computed using sophisticated analytical procedures) for use in simplified design tools. RP Ebeling, RM (reprint author), USA,ENGINEER WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 15 TC 5 Z9 5 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9410 J9 J GEOTECH ENG-ASCE JI J. Geotech. Eng.-ASCE PD MAR PY 1996 VL 122 IS 3 BP 216 EP 225 DI 10.1061/(ASCE)0733-9410(1996)122:3(216) PG 10 WC Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA TX188 UT WOS:A1996TX18800006 ER PT J AU Zappi, ME Rogers, BA Teeter, CL Gunnison, D Bajpai, R AF Zappi, ME Rogers, BA Teeter, CL Gunnison, D Bajpai, R TI Bioslurry treatment of a soil contaminated with low concentrations of total petroleum hydrocarbons SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE bioremediation; PAH; slurry bioreactors; BTEX; aerobic process ID POLYCYCLIC AROMATIC-HYDROCARBONS; BIOREMEDIATION; CREOSOTE AB The objective of this study was to investigate the degradation patterns of petroleum hydrocarbons during bioremediation of soils containing low levels of contaminants. The study was conducted in pilot-scale bioslurry reactors (701) under aerobic conditions. The reactors were ,quipped with a process-gas-recirculation system to ensure complete containment and eventually complete degradation of all contaminants. The concentrations of benzene, toluene, ethyl benzene, and xylenes (BTEX-compounds) and of naphthalene, anthracene, and phenanthrene were found to decrease rapidly. But, polyaromatic hydrocarbons (PAHs) containing >3 aromatic rings did not show significant biodegradation. Addition of rapidly metabolizing substrates such as sodium acetate and/or phenanthrene did not enhance the degradation of PAHs containing >3 aromatic rings. However, the augmented phenanthrene was rapidly metabolized. C1 USA,CORPS ENGINEERS,WATERWAYS EXPT STN,ENVIRONM LAB,VICKSBURG,MS 39180. UNIV MISSOURI,DEPT CHEM ENGN,COLUMBIA,MO 65211. NR 29 TC 33 Z9 51 U1 2 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 J9 J HAZARD MATER JI J. Hazard. Mater. PD MAR PY 1996 VL 46 IS 1 BP 1 EP 12 DI 10.1016/0304-3894(95)00091-7 PG 12 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA UA117 UT WOS:A1996UA11700001 ER PT J AU Stech, FJ AF Stech, FJ TI Science of coercion: Communication research and psychological warfare 1945-1960 - Simpson,C SO JOURNAL OF INTERDISCIPLINARY HISTORY LA English DT Book Review RP Stech, FJ (reprint author), USA,WAR COLL,STRATEG STUDIES INST,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU MIT PRESS PI CAMBRIDGE PA 55 HAYWARD ST JOURNALS DEPT, CAMBRIDGE, MA 02142 SN 0022-1953 J9 J INTERDISCIPL HIST JI J. Interdiscip. Hist. PD SPR PY 1996 VL 26 IS 4 BP 741 EP 742 DI 10.2307/205089 PG 2 WC History SC History GA UA083 UT WOS:A1996UA08300047 ER PT J AU Walsh, DS Tsou, HC Harrington, A James, WD Peacocke, M AF Walsh, DS Tsou, HC Harrington, A James, WD Peacocke, M TI Clonality of basal cell carcinoma - Molecular analysis of an interesting case SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Article DE androgen receptor gene (HUMARA); restriction fragment length polymorphism; polymerase chain reaction ID FRAGMENT-LENGTH-POLYMORPHISMS; X-CHROMOSOME INACTIVATION; POLYMERASE CHAIN-REACTION; GENE; ORIGIN AB Tumor cells represent a single clone of cells that have undergone a series of mutations in genomic DNA, This process, known as clonal evolution, is a distinguishing feature of cancer. The human androgen receptor gene (HUMARA; GenBank) contains a highly polymorphic cytosine-adenine-guanine trinucleotide repeat that can be used to determine clonality by depicting X chromosome inactivation patterns. Random X chromosome inactivation is consistent with polyclonality; nonrandom X chromosome inactivation indicates a clonal population of cells. Basal cell carcinoma (BCC) demonstrates an atypical growth pattern in that it grows slowly, rarely metastasizes, and is rarely lethal, Whether this tumor results from the accumulation of mutations in a single cell with subsequent clonal expansion or reflects a polyclonal response by a group of cells to a growth stimulus is unknown, To provide further insight into the molecular events characterizing BCCs, we determined the clonal origin of five nodular BCCs from a female patient by analyzing X chromosome inactivation patterns at the HUMARA locus. AU tumors demonstrated a nonrandom pattern of X chromosome inactivation, consistent with monoclonal proliferation, These findings provide strong genetic evidence that sporadic BCCs develop by clonal evolution and support the contention that a series of mutations in a single cell is responsible for the altered growth state seen in these transformed epithelial cells. C1 WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307. TUFTS UNIV NEW ENGLAND MED CTR,DEPT DERMATOL,BOSTON,MA 02111. FU NIA NIH HHS [AG-09927] NR 23 TC 14 Z9 14 U1 0 U2 1 PU BLACKWELL SCIENCE INC PI CAMBRIDGE PA 238 MAIN ST, CAMBRIDGE, MA 02142 SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD MAR PY 1996 VL 106 IS 3 BP 579 EP 582 DI 10.1111/1523-1747.ep12344982 PG 4 WC Dermatology SC Dermatology GA UB968 UT WOS:A1996UB96800034 PM 8648198 ER PT J AU Nath, J Tulsi, P Kray, K Kausalya, S AF Nath, J Tulsi, P Kray, K Kausalya, S TI Nitric oxide generation in activated human neutrophils: Studies in unprimed and LPS-primed cells SO JOURNAL OF INVESTIGATIVE MEDICINE LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT HEMATOL,WASHINGTON,DC. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 1081-5589 J9 J INVEST MED JI J. Invest. Med. PD MAR PY 1996 VL 44 IS 3 BP A267 EP A267 PG 1 WC Medicine, General & Internal; Medicine, Research & Experimental SC General & Internal Medicine; Research & Experimental Medicine GA UG207 UT WOS:A1996UG20700410 ER PT J AU Fisher, DL Wisher, RA Ranney, TA AF Fisher, DL Wisher, RA Ranney, TA TI Optimal static and dynamic training schedules: State models of skill acquisition SO JOURNAL OF MATHEMATICAL PSYCHOLOGY LA English DT Article ID CONTROLLED PROCESSING THEORY; VISUAL-SEARCH; INTEGRATION; COMPONENTS; PRINCIPLES; CAPACITY; TASKS AB Training takes place in complex environments. Typically, there are many different tasks which need to be learned; each task can be performed at one of several different levels of proficiency and each level of proficiency within a given task can be trained in one of various different ways. Much is known about what tasks need to be trained in order to achieve a particular objective, what methods are best for training a particular level of a particular task, and what measures should be used to evaluate training. Curiously, given that the tasks, methods, and measures have been selected, very little is known about how to determine which level of which task it is best to train in each session. In this article, a framework for pursuing the optimization of training schedules which are sensitive to (dynamic) and not sensitive to (static) the session by session (trial by trial) progress of the learner is developed. The framework takes as its starting point the early state models of learning first proposed within mathematical psychology in the 1950s. We show that the stale models can be used to predict how performance will vary as a function of the scheduling of training trials. Practically, it is important to consider the effect of changes in the scheduling of training trials because such changes can substantially reduce the time it takes any given individual to learn a composite skill. Theoretically, it is important to consider the effect of changes in the scheduling of training trials because such changes can potentially provide the answers to a number of questions central to research in training. We conclude that the state models of learning provide both of the hoped for practical and theoretical benefits. (C) 1996 Academic Press, Inc. C1 USA,RES INST BEHAV & SOCIAL SCI,WASHINGTON,DC 20310. LIBERTY MUTUAL RES CTR,HOPKINTON,MA. RP Fisher, DL (reprint author), UNIV MASSACHUSETTS,COLL ENGN,AMHERST,MA 01003, USA. NR 52 TC 4 Z9 4 U1 3 U2 7 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0022-2496 J9 J MATH PSYCHOL JI J. Math. Psychol. PD MAR PY 1996 VL 40 IS 1 BP 30 EP 47 DI 10.1006/jmps.1996.0002 PG 18 WC Mathematics, Interdisciplinary Applications; Social Sciences, Mathematical Methods; Psychology, Mathematical SC Mathematics; Mathematical Methods In Social Sciences; Psychology GA UA591 UT WOS:A1996UA59100002 ER PT J AU Frances, SP Khlaimanee, N AF Frances, SP Khlaimanee, N TI Laboratory tests of arthropod repellents against Leptotrombidium deliense - Noninfected and infected with Rickettsia tsutsugamushi - And noninfected L-fletcheri (Acari: Trombiculidae) SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Trombiculidae; Leptotrombidium deliense; Leptotrombidium fletcheri; Rickettsia tsutsugamushi; repellents AB Laboratory tests were conducted to compare the response of noninfected Leptotrombidium deliense Sambon and Leptotrombidium fletcheri (Womersley & Heaslip) and L. deliense naturally infected with Rickettsia tsutsugamushi, the etiologic agent of scrub typhus, to 8 chemical repellents and toxicants. Low concentrations of permethrin, dimethylphthalate, diethyl methylbenzamide, benzyl benzoate, di-n-propyl 2,5-pyridine-dicarboxylate, 1-(3-Cyclohexen-1-yl-carbonyl)-2-methylpiperidine (AI3-37220), 2-hydroxymethyl-cyclohexyl acetic acid lactone, and a high concentration of dibutylphthalate (DBP) were toxic for noninfected larvae of both species tested. The median effective knockdown time for all chemicals, except 1% AI3-37220 and 5% permethrin, were longer against infected L. deliense than uninfected larvae of the same species. However, the results indicate that low concentrations of all chemicals, except DBP, should be effective against 2 important vectors of scrub typhus. C1 USA,MED COMPONENT,ARMED FORCES RES INST MED SCI,DEPT ENTOMOL,BANGKOK 10400,THAILAND. NR 13 TC 9 Z9 10 U1 0 U2 1 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAR PY 1996 VL 33 IS 2 BP 232 EP 235 PG 4 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA TX079 UT WOS:A1996TX07900008 PM 8742527 ER PT J AU Long, JB Gordon, J Bettencourt, JA Bolt, SL AF Long, JB Gordon, J Bettencourt, JA Bolt, SL TI Laser-Doppler flowmetry measurements of subcortical blood flow changes after fluid percussion brain injury in rats SO JOURNAL OF NEUROTRAUMA LA English DT Article DE brain injury; cerebrovascular; laser-Doppler flowmetry; cerebral blood flow ID EXPERIMENTAL HEAD-INJURY; FOCAL CEREBRAL-ISCHEMIA; RADIOLABELED MICROSPHERES; GLUCOSE-UTILIZATION; PERFUSION-PRESSURE; PROTEIN-SYNTHESIS; THRESHOLDS; ISOFLURANE; VULNERABILITY; METABOLISM AB Laser-Doppler flowmetry (LDF) was used to record subcortical cerebral blood flow in hippocampus and striatum immediately following parasaggital fluid percussion brain injuries of mild to moderate severity (2.58 +/- 0.09 atm, 10-11 msec duration) in spontaneously breathing anesthetized rats. At 5 min postinjury, mean blood flow decreased bilaterally by 20-30% in both brain structures, and remained significantly reduced during the remainder of the 60 min postinjury recording interval. Blood flow did not change in the sham-injured rats. Subsequent beam-walk, beam-balance, and rope-hang assessments revealed significant neurological impairments in the injured rats but not in the sham controls. The magnitude of the blood flow changes and the severity of the ensuing neurological impairment were significantly correlated. Histopathological assessments revealed hemorrhagic contusions within ipsilateral cortical regions, occasional neuronal necrosis within underlying thalamus and CA3 and CA4 sectors of the hippocampus, and neuronal cell loss in the hilus of the dentate gyrus. In a second series of experiments, radiolabeled microspheres were used to validate the LDF blood flow measurements. The microsphere measurements revealed that the preinjury baseline and postinjury right hippocampal blood flow changes were not significantly altered by the intrahippocampal presence of an LDF probe, verifying that the LDF probe was not by itself an unacceptably disruptive influence on local cerebrovascular reactivity. Moreover, when right hippocampal blood flow was simultaneously evaluated in injured rats by both techniques, the relative blood flow changes were significantly correlated. These results indicate that laser-Doppler flowmetry provides a potentially useful means to appreciate acute regional cerebrovascular changes relative to other measures of outcome after brain trauma. C1 WALTER REED ARMY INST RES,DIV NEUROSCI,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,ANESTHESIA & OPERAT SERV,WASHINGTON,DC 20307. NR 73 TC 13 Z9 13 U1 0 U2 2 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD MAR PY 1996 VL 13 IS 3 BP 149 EP 162 DI 10.1089/neu.1996.13.149 PG 14 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA UD469 UT WOS:A1996UD46900004 PM 8965324 ER PT J AU Carter, BS AF Carter, BS TI Macrosomic infants of nondiabetic mothers SO JOURNAL OF PEDIATRICS LA English DT Letter RP Carter, BS (reprint author), WALTER REED ARMY MED CTR, DEPT PEDIAT, WASHINGTON, DC 20307 USA. OI Carter, Brian/0000-0003-0539-9164 NR 4 TC 2 Z9 2 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 EI 1097-6833 J9 J PEDIATR-US JI J. Pediatr. PD MAR PY 1996 VL 128 IS 3 BP 439 EP 440 DI 10.1016/S0022-3476(96)70307-4 PG 2 WC Pediatrics SC Pediatrics GA UA572 UT WOS:A1996UA57200029 PM 8774522 ER PT J AU Callahan, CW AF Callahan, CW TI Cough with asthma: Variant or norm? SO JOURNAL OF PEDIATRICS LA English DT Letter RP Callahan, CW (reprint author), TRIPLER ARMY MED CTR, DEPT PEDIAT, SECT PULMONOL, HONOLULU, HI 96859 USA. NR 3 TC 3 Z9 4 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 EI 1097-6833 J9 J PEDIATR-US JI J. Pediatr. PD MAR PY 1996 VL 128 IS 3 BP 440 EP 440 DI 10.1016/S0022-3476(96)70308-6 PG 1 WC Pediatrics SC Pediatrics GA UA572 UT WOS:A1996UA57200030 PM 8774523 ER PT J AU Czuszak, CA Tolson, GE Kudryk, VL Hanson, BS Billman, MA AF Czuszak, CA Tolson, GE Kudryk, VL Hanson, BS Billman, MA TI Development of an exostosis following a free gingival graft: Case report SO JOURNAL OF PERIODONTOLOGY LA English DT Article DE exostoses; grafts, gingival; osteoma; gingiva surgery ID KERATINIZED GINGIVA; WIDTH AB A case of an exostosis developing subsequent to the placement of a free gingival graft in the mandibular premolar area is described. C1 USA,PERIODONT RESIDENCY PROGRAM,FT GORDON,GA. NR 25 TC 5 Z9 6 U1 0 U2 0 PU AMER ACAD PERIODONTOLOGY PI CHICAGO PA 737 NORTH MICHIGAN AVENUE, SUITE 800, CHICAGO, IL 60611-2690 SN 0022-3492 J9 J PERIODONTOL JI J. Periodont. PD MAR PY 1996 VL 67 IS 3 BP 250 EP 253 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA UE241 UT WOS:A1996UE24100011 PM 8708957 ER PT J AU Choy, FK Huang, S Zakrajsek, JJ Handschuh, RF Townsend, DP AF Choy, FK Huang, S Zakrajsek, JJ Handschuh, RF Townsend, DP TI Vibration signature analysis of a faulted gear transmission system SO JOURNAL OF PROPULSION AND POWER LA English DT Article; Proceedings Paper CT AIAA/ASME/SAE/ASEE 30th Joint Propulsion Conference CY JUN 27-29, 1994 CL INDIANAPOLIS, IN SP AIAA, ASME, SAE, ASEE ID TIME AB A comprehensive procedure in predicting faults in gear transmission systems under normal operating conditions is presented. Experimental data were obtained from a spiral bevel gear fatigue test rig at NASA Lewis Research Center. Time-synchronous-averaged vibration data were recorded throughout the test as the fault progressed from a small single pit to severe pitting over several teeth, and finally tooth fracture. A numerical procedure based on the Wigner-Ville distribution was used to examine the time-averaged vibration data. Results from the Wigner-Ville procedure are compared to results from a variety of signal analysis techniques that include time-domain analysis methods and frequency analysis methods. Using photographs of the gear tooth at various stages of damage, the limitations and accuracy of the various techniques are compared and discussed, Conclusions are drawn from the comparison of the different approaches as well as the applicability of the Wigner-Ville method in predicting gear faults. C1 NASA,LEWIS RES CTR,AEROSP DIRECTORATE,CLEVELAND,OH 44135. USA,AVIAT SYST COMMAND,AEROSP DIRECTORATE,CLEVELAND,OH 44135. RP Choy, FK (reprint author), UNIV AKRON,DEPT MECH ENGN,AKRON,OH 44325, USA. NR 13 TC 12 Z9 12 U1 0 U2 1 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0748-4658 J9 J PROPUL POWER JI J. Propul. Power PD MAR-APR PY 1996 VL 12 IS 2 BP 289 EP 295 DI 10.2514/3.24026 PG 7 WC Engineering, Aerospace SC Engineering GA UB282 UT WOS:A1996UB28200011 ER PT J AU Royster, JD Berger, EH Merry, CJ Nixon, CW Franks, JR Behar, A Casali, JG DixonErnst, C Kieper, RW Mozo, BT Ohlin, D Royster, LH AF Royster, JD Berger, EH Merry, CJ Nixon, CW Franks, JR Behar, A Casali, JG DixonErnst, C Kieper, RW Mozo, BT Ohlin, D Royster, LH TI Development of a new standard laboratory protocol for estimating the field attenuation of hearing protection devices .1. Research of Working Group 11, Accredited Standards Committee S12, noise SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article AB This paper describes research conducted by Working Group 11 of Accredited Standards Committee S12, Noise, to develop procedures to estimate the field performance of hearing protection devices (HPDs). Current standardized test methods overestimate the attenuation achieved by workers in everyday use on the job. The goal was to approximate the amount of attenuation that can be achieved by noise-exposed populations in well-managed real-world hearing conservation programs, while maintaining acceptable interlaboratory measurement variability. S12/WG11 designed two new laboratory-based protocols for measuring real-ear attenuation at threshold, with explicit procedures for subject selection, training, supervision, and HPD fitting. After pilot-testing, S12/WG11 conducted a full-scale study of three types of earplugs and one earmuff tested by four independent laboratories using both protocols. The protocol designated as "subject-fit" assessed the attenuation achieved by subjects who were experienced in threshold audiometry, but naive with respect to the use of hearing protection, when they fit HPDs by following manufacturers' instructions without any experimenter assistance. The attenuation results from the subject-fit method corresponded more closely to real-world data than results from the other protocol tested, which allowed the experimenter to coach subjects in HPD use, Comparisons of interlaboratory measurement variability for the subject-fit procedure to previous interlaboratory studies using other protocols indicated that the measurements with the new procedure are at least as reproducible as those obtained with existing standardized methods. Therefore, the subject-fit protocol was selected for consideration for use in future revisions of HPD attenuation test standards. (C) 1996 Acoustical Society of America. C1 CABOT SAFETY CORP, EAR, INDIANAPOLIS, IN 46268 USA. NIOSH, CINCINNATI, OH 45226 USA. USAF, ARMSTRONG LAB, WRIGHT PATTERSON AFB, OH 45433 USA. BEHAR NOISE CONTROL, SCARBOROUGH, ON M1M 2X8, CANADA. VIRGINIA POLYTECH INST & STATE UNIV, BLACKSBURG, VA 24061 USA. ALCOA, PITTSBURGH, PA 15219 USA. USA, AEROMED RES LAB, FT RUCKER, AL 36330 USA. USA, CTR HLTH PROMOT & PREVENT MED, ABERDEEN PROVING GROUND, MD 21010 USA. N CAROLINA STATE UNIV, RALEIGH, NC 27695 USA. RP ENVIRONM NOISE CONSULTANTS INC, POB 30698, RALEIGH, NC 27622 USA. RI Behar, Alberto/B-3967-2008 NR 30 TC 18 Z9 19 U1 1 U2 4 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 EI 1520-8524 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD MAR PY 1996 VL 99 IS 3 BP 1506 EP 1526 DI 10.1121/1.414729 PG 21 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA UA036 UT WOS:A1996UA03600025 ER PT J AU Smith, KJ Skelton, HG Barrett, TL Welch, M Beard, J AF Smith, KJ Skelton, HG Barrett, TL Welch, M Beard, J TI Histologic and immunohistochemical features in biopsy sites in which bovine collagen matrix was used for hemostasis SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID INJECTABLE COLLAGEN; CELL-ADHESION; SPONGE; SKIN AB Background: Bovine collagen matrix (Helistat and Helatene), which is used primarily for hemostasis, decreases wound contracture in skin biopsy sites and promotes wound granulation. Objective: Our purpose was to evaluate excision specimens of previous biopsy sites to determine whether there are histologic differences between cases in which bovine collagen matrix was used for hemostasis and those in which it was not used. Methods: Thirty-two diagnostic punch biopsies were done with hemostasis obtained with bovine collagen matrix in 24 biopsies and by pressure alone in eight, The biopsy sites were reexcised at various time intervals, and the histologic and immunohistochemical features were evaluated and compared. Results: In specimens in which collagen matrix was used, migration of stromal and epithelial cells along the bovine collagen matrix was evident by 2 days and had progressed rapidly by 4 days. Around and within the matrix hyaluronic acid increased during the first 8 to 10 days. Initially stromal cells stained with CD34 and reticulum fibers were present at 8 to 10 days. At 12 to 15 days, factor XIIIa(+) stromal cells were present within the matrix, and host collagen fibers were present and well-oriented within the degenerating matrix. Biopsy specimens allowed to heal without the matrix showed a delayed and an uneven increase in hyaluronic acid. Furthermore, the granulation tissue within the dermis showed no organization with a persistent acute inflammatory infiltrate and increased muscle actin-positive stromal cells as scar formation proceeded. Conclusion: Bovine collagen products appear to provide a matrix that promotes thrombosis, The collagen matrix also promotes migration and attachment of stromal and epithelial cells, thereby organizing and accelerating wound healing. C1 ARMED FORCES INST PATHOL,DEPT DERMATOPATHOL,WASHINGTON,DC 20306. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307. USN HOSP,SAN DIEGO,CA. NR 21 TC 15 Z9 17 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD MAR PY 1996 VL 34 IS 3 BP 434 EP 438 DI 10.1016/S0190-9622(96)90435-1 PG 5 WC Dermatology SC Dermatology GA TZ292 UT WOS:A1996TZ29200006 PM 8609255 ER PT J AU Rutledge, LC Gupta, RK Mehr, ZA Buescher, MD Reifenrath, WG AF Rutledge, LC Gupta, RK Mehr, ZA Buescher, MD Reifenrath, WG TI Evaluation of controlled-release mosquito repellent formulations SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article ID COMPARATIVE SENSITIVITY; LABORATORY EVALUATION AB Eight polymer and 9 microcapsule formulations of deer were tested on laboratory rabbits against Aedes aegypti and Anopheles albimanus. Several formulations were significantly more effective than simple (unformulated) deer at the same strength for periods up to 24 h. Best results were obtained with a polymer formulation containing a high molecular weight fatty acid and 3 microcapsule formulations containing lanolin, gum arabic, gelatin, tannic acid, stearic acid, polypropylene glycol, water, and a commercial lotion in the microcapsule and carrier fractions. C1 WALTER REED ARMY MED CTR,DEPT ENTOMOL,WASHINGTON,DC 20307. DEF LOGIST AGCY,CAMERON STN,ALEXANDRIA,VA 22304. REIFENRATH CONSULTING & RES,RICHMOND,CA 94804. NR 18 TC 23 Z9 26 U1 0 U2 5 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD MAR PY 1996 VL 12 IS 1 BP 39 EP 44 PG 6 WC Entomology SC Entomology GA UH704 UT WOS:A1996UH70400006 PM 8723256 ER PT J AU Rattanarithikul, R Konishi, E Linthicum, KJ AF Rattanarithikul, R Konishi, E Linthicum, KJ TI Observations on nocturnal biting activity and host preference of anophelines collected in southern Thailand SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article ID CULICIDAE; MOSQUITOS; MALARIA; DIPTERA; PATTERNS AB Over a 13-month period, 5,127 adult female mosquitoes were collected on human bait during multiple collecting periods between 1800 and 0600 h in 5 villages in southern Thailand. There were marked differences in the biting activity of different species at each of the villages studied. Anopheles maculatus and Anopheles sawadwongporni were collected most often at dusk or in the first hours of darkness between 1800 and 2100 h. Although specimens of Anopheles dirus were collected consistently between 1900 and 0400 h, peak collections were made between 2000 and 2300 h. Anopheles minimus was collected consistently throughout the night without a clearly discernible peak. Of more than 2,400 Anopheles mosquitoes collected in CDC light traps, 133 specimens (5.4%) contained blood, nearly all of which was identified by enzyme-linked immunosorbent assay (ELISA) to be of bovine origin. Ten specimens contained blood from more than one host species. C1 KOBE UNIV,SCH MED,DEPT MED ZOOL,KOBE 650,JAPAN. RP Rattanarithikul, R (reprint author), ARMED FORCES RES INST MED SCI,US ARMY MED COMPONENT,DEPT ENTOMOL,RAJVITHI RD,BANGKOK 10400,THAILAND. NR 24 TC 18 Z9 18 U1 0 U2 0 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD MAR PY 1996 VL 12 IS 1 BP 52 EP 57 PG 6 WC Entomology SC Entomology GA UH704 UT WOS:A1996UH70400008 PM 8723258 ER PT J AU Rattanarithikul, R Linthicum, KJ Konishi, E AF Rattanarithikul, R Linthicum, KJ Konishi, E TI Seasonal abundance and parity rates of Anopheles species in southern Thailand SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article ID MALARIA AB Mosquitoes were collected with human bait, animal bait, and CO2-baited light traps during a 13-month period in 5 villages located along the Myanmar border in southern Thailand. Altogether, 11,608 adult females consisting of 21 anopheline species were collected. Abundance of species varied according to the village where collections were made. In one village that was studied most intensely, Anopheles minimus was the most commonly collected species, representing 55.6, 10.6, and 56.5% of the human bait, cattle bait, and light trap collections, respectively. In addition, An. minimus was abundant throughout the year, whereas Anopheles maculatus was most commonly collected in July and August coincident with the rainy season. Anopheles sawadwongporni, abundant at the beginning and the end of the rainy season, was most commonly collected in June. Anopheles dirus was most abundant in April; however, it represented only 3.6% of all mosquitoes collected that month. Of 813 females collected in Palao-U Village and dissected, 38.9% were parous. C1 KOBE UNIV,SCH MED,DEPT MED ZOOL,KOBE 650,JAPAN. RP Rattanarithikul, R (reprint author), USA MED COMPONENT,ARMED FORCES RES INST MED SCI,DEPT ENTOMOL,315-6 RAJVITHI RD,BANGKOK 10400,THAILAND. NR 23 TC 19 Z9 19 U1 0 U2 3 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD MAR PY 1996 VL 12 IS 1 BP 75 EP 83 PG 9 WC Entomology SC Entomology GA UH704 UT WOS:A1996UH70400012 PM 8723262 ER PT J AU Baimai, V Kijchalao, U Rattanarithikul, R AF Baimai, V Kijchalao, U Rattanarithikul, R TI Metaphase karyotypes of Anopheles of Thailand and Southeast Asia .5. The Myzomyia Series, subgenus cellia (Diptera: Culicidae) SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article ID CULICIFACIES COMPLEX; CHROMOSOMAL EVIDENCE AB Metaphase karyotypes of 9 species of the Myzomyia Series show intra- and interspecific differences based on quantitative variation and distribution of constitutive heterochromatin in the sex chromosomes or the centromeric regions of the autosome pairs or both. Anopheles jeyporiensis and Anopheles aconitus each exhibit 4 forms of mitotic karyotypes, which may reflect interspecific differences within each taxon. The well-defined genetic species within the Anopheles minimus and the Anopheles culicifacies complexes clearly exhibit distinctive metaphase karyotypes that can be used as diagnostic characters for separating these sibling species, which are difficult to identify by morphological criteria alone. Our analysis on metaphase karyotypes of Anopheles pampanai, Anopheles varuna, and Anopheles flavirostris also confirms their morphological identification based on heterochromatin differences in the sex chromosomes and autosome 2. C1 ARMED FORCES RES INST MED SCI,DEPT MED ENTOMOL,BANGKOK 10400,THAILAND. RP Baimai, V (reprint author), MAHIDOL UNIV,FAC SCI,DEPT BIOL,RAMA VI RD,BANGKOK 10400,THAILAND. NR 25 TC 18 Z9 22 U1 2 U2 2 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD MAR PY 1996 VL 12 IS 1 BP 97 EP 105 PG 9 WC Entomology SC Entomology GA UH704 UT WOS:A1996UH70400015 PM 8723265 ER PT J AU Rutledge, LC Gupta, RK Mehr, ZA Buescher, MD Reifenrath, WG AF Rutledge, LC Gupta, RK Mehr, ZA Buescher, MD Reifenrath, WG TI Evaluation of the laboratory rabbit model for screening topical mosquito repellents SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article ID DIPTERA; PSYCHODIDAE; TESTS AB The laboratory rabbit was evaluated as a model for screening topical mosquito repellents, using data obtained in tests of deet (N, N-diethyl-3-methylbenzamide) against Aedes aegypti on humans and rabbits. Host-specific differences in the action of the test material were quantified by multiple regression analysis. The test material was less effective but more persistent in tests on rabbits, and responses of the mosquito test population were more variable. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307. DEF LOGIST AGCY,ALEXANDRIA,VA 22304. REIFENRATH CONSULTING & RES,RICHMOND,CA 94804. NR 15 TC 4 Z9 4 U1 1 U2 1 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD MAR PY 1996 VL 12 IS 1 BP 142 EP 143 PG 2 WC Entomology SC Entomology GA UH704 UT WOS:A1996UH70400023 PM 8723273 ER PT J AU Zheng, JP Jow, TR Jia, QX Wu, XD AF Zheng, JP Jow, TR Jia, QX Wu, XD TI Proton insertion into ruthenium oxide film prepared by pulsed laser deposition SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID ELECTRODES AB Electrochemical properties of ruthenium oxide (RuO2) films with different degrees of crystallinity were studied. The RuO2 films were grown by pulsed laser deposition at substrate temperatures from 30 to 400 degrees C. At low temperatures, the amorphous phase of RuO2 films was formed. At high temperatures, the crystalline phase of RuO2 films was obtained. From the cyclic voltammetric study in H2SO4 solution, it was found that the current response for an electrode of the amorphous RuO2 film was higher than that of the crystalline film. A proton diffusion length of larger than 5.8 nm was obtained on the RuO2 film prepared at 30 degrees C. C1 LOS ALAMOS NATL LAB,SUPERCOND TECHNOL CTR,LOS ALAMOS,NM 87545. RP Zheng, JP (reprint author), USA,RES LAB,PHYS SCI DIRECTORATE,FT MONMOUTH,NJ 07703, USA. RI Jia, Q. X./C-5194-2008 NR 13 TC 23 Z9 27 U1 4 U2 11 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 10 SOUTH MAIN STREET, PENNINGTON, NJ 08534 SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PD MAR PY 1996 VL 143 IS 3 BP 1068 EP 1070 DI 10.1149/1.1836584 PG 3 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA UC203 UT WOS:A1996UC20300057 ER PT J AU Bauman, RA Raslear, TG Hursh, SR Shurtleff, D Simmons, L AF Bauman, RA Raslear, TG Hursh, SR Shurtleff, D Simmons, L TI Substitution and caloric regulation in a closed economy SO JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR LA English DT Article DE closed economy; demand; substitution; regulation; lever press; rats; monkeys ID BODY-WEIGHT; BEHAVIORAL ECONOMICS; MEAL PATTERNS; SET POINTS; FOOD; DEMAND; RATS; SATIETY; GLUCOSE; TASTE AB Three experiments were conducted to study the effect of an imperfect substitute for food on demand for food in a closed economy. In Experiments 1 and 2, rats pressed a lever for their entire daily food ration, and a fixed ratio of presses was required for each food pellet. In both experiments, the fixed ratio was held constant during a daily session but was increased between sessions. The fixed ratio was increased over a series of daily sessions once in the absence of concurrently available sucrose and again when sucrose pellets were freely available. For both series, increases in the fixed ratio reduced food intake, but body weight was reduced only in the no-sucrose condition. In the sucrose condition, body weight and total caloric intake (sucrose plus food) were relatively unaffected by increases in the fixed ratio. At all fixed ratios, food intake was proportionally reduced by the intake of sucrose. In Experiment 3, monkeys obtained food or saccharin by pressing keys; the fixed ratio of presses per food pellet was increased once when tap water was each monkey's only source of fluid, again when each monkey's water was sweetened with saccharin, and a third time when each monkey had concurrent access to the saccharin solution and plain water. Increases in the fixed ratio, but not the intake of the saccharin solution, reduced each monkey's food intake. Because neither rats' sucrose nor monkeys' saccharin intakes affected the slope of the respective demand curves for food, monkeys and rats increased their daily output of presses and thereby defended their daily intake of those complementary elements of food. However, sucrose reduced rats' food intake. The relative constancy of body weight and total caloric intake in the sucrose condition is consistent with the possibility that rats tended to regulate caloric intake. RP Bauman, RA (reprint author), WALTER REED ARMY MED CTR,DEPT NEUROBEHAV ASSESSMENT,DIV NEUROSCI,BLDG 40,WASHINGTON,DC 20307, USA. NR 57 TC 13 Z9 13 U1 0 U2 1 PU SOC EXP ANALYSIS BEHAVIOR INC PI BLOOMINGTON PA INDIANA UNIV DEPT PSYCHOLOGY, BLOOMINGTON, IN 47405 SN 0022-5002 J9 J EXP ANAL BEHAV JI J. Exp. Anal. Behav. PD MAR PY 1996 VL 65 IS 2 BP 401 EP 422 DI 10.1901/jeab.1996.65-401 PG 22 WC Psychology, Biological; Behavioral Sciences; Psychology, Experimental SC Psychology; Behavioral Sciences GA TZ557 UT WOS:A1996TZ55700004 PM 8851540 ER PT J AU Sasser, LB Cushing, JA Mellick, PW Kalkwarf, DR Dacre, JC AF Sasser, LB Cushing, JA Mellick, PW Kalkwarf, DR Dacre, JC TI Subchronic toxicity evaluation of lewisite in rats SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH LA English DT Article ID INDUCED GASTRIC TOXICITY; BUTYLATED HYDROXYANISOLE; F344 RATS; FORESTOMACH; CARCINOMA; LESIONS AB Health and exposure criteria have not been established fdr lewisite [dichloro(2-chlorovinyl) arsine], a potent toxic vesicant that reacts with the sulfhydryl groups of proteins through its arsenic group. Sixty Sprague-Dawley rats of each sex, 6-7 wk old, were divided into 6 groups (10/group/sex) and gavaged with either 0, 0.01, 0.1, 0.5, 1.0, or 2.0 mg/kg of lewisite in sesame oil 5 d/wk for 13 wk. No significant dose-related change in body weight was observed. At the high dose, serum protein, creatinine, SCOT, and SGPT were decreased in males; lymphocytes and platelets were increased in females. A treatment-related lesion was detected in the forestomach of both sexes at 2.0 mg/kg. These lesions were characterized by necrosis of the stratified squamous epithelium accompanied by infiltration of neutrophils and macrophages, proliferation of neocapillaries, hemorrhage, edema, and fibroblast proliferation. Mild acute inflammation of the glandular stomach was also observed in some cases at 1.0 and 2.0 mg/kg. Early deaths were attributed to severe inflammation of the upper and/or lower respiratory tract, possibly from deposition or reflex of test material into the pharynx. Estimated dose range for NOEL appears to be >0.5 and <1.0 mg/kg when administered orally. C1 USA, BIOMED RES & DEV LAB, HLTH EFFECTS RES DIV, FREDERICK, MD 21702 USA. RP Sasser, LB (reprint author), PACIFIC NW LAB, DEPT BIOL & CHEM, POB 999, RICHLAND, WA 99352 USA. NR 24 TC 8 Z9 8 U1 0 U2 1 PU TAYLOR & FRANCIS PI BRISTOL PA 1900 FROST ROAD, SUITE 101, BRISTOL, PA 19007-1598 SN 0098-4108 J9 J TOXICOL ENV HEALTH JI J. Toxicol. Environ. Health PD MAR PY 1996 VL 47 IS 4 BP 321 EP 334 DI 10.1080/009841096161672 PG 14 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA UA178 UT WOS:A1996UA17800002 PM 8600286 ER PT J AU Yowler, CJ Martin, RR AF Yowler, CJ Martin, RR TI 7th International symposium of weapons traumatology and wound ballistics - St Petersburg, Russia - September 1994 - Foreword SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Editorial Material C1 BROOKE ARMY MED CTR,TRAUMA CRIT CARE SERV,FT SAM HOUSTON,TX 78234. RP Yowler, CJ (reprint author), USA,INST SURG RES,BURN STUDY BRANCH,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD MAR PY 1996 VL 40 IS 3 SU S BP S2 EP S2 PG 1 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA UB897 UT WOS:A1996UB89700002 ER PT J AU Coch, CA AF Coch, CA TI Containment islands: A solution for ports and the environment SO JOURNAL OF URBAN TECHNOLOGY LA English DT Article RP Coch, CA (reprint author), USA,CORPS ENGINEERS,N ATLANTIC DIV,WASHINGTON,DC 20310, USA. NR 14 TC 2 Z9 2 U1 0 U2 1 PU SOC URBAN TECHNOLOGY PI BROOKLYN PA SUBSCRIPTION DEPT, 300 JAY ST, BROOKLYN, NY 11201 SN 1063-0732 J9 J URBAN TECHNOL JI J. Urban Technol. PD SPR PY 1996 VL 3 IS 2 BP 39 EP 63 PG 25 WC Urban Studies SC Urban Studies GA VK497 UT WOS:A1996VK49700005 ER PT J AU Moul, JW Maygarden, SJ Ware, JL Mohler, JL Maher, PD Schenkman, NS Ho, CK AF Moul, JW Maygarden, SJ Ware, JL Mohler, JL Maher, PD Schenkman, NS Ho, CK TI Cathepsin D and epidermal growth factor receptor immunohistochemistry does not predict recurrence of prostate cancer in patients undergoing radical prostatectomy SO JOURNAL OF UROLOGY LA English DT Article DE prostatic neoplasms; cathepsin; immunohistochemistry; prostatectomy ID BREAST-CANCER; MONOCLONAL-ANTIBODY; FACTOR-ALPHA; BENIGN; ADENOCARCINOMA; HYPERPLASIA; EXPRESSION; CARCINOMA; PROGNOSIS AB Purpose: We determined if immunohistochemical expression of the epidermal growth factor receptor and cathepsin D in the primary tumor was of prognostic value in clinically localized prostate cancer after radical prostatectomy. Materials and Methods: Immunohistochemical staining for epidermal growth factor receptor and cathepsin D was performed on 105 radical prostatectomy specimens from 2 academic centers. The epidermal growth factor receptor and cathepsin D expressions were graded using H scoring by an experienced pathologist blinded to other patient data, and compared with age, grade, stage, race and initial serologic (prostate specific antigen) recurrence. Univariate and multivariate statistical testing was performed. Results: Immunohistochemically detectable epidermal growth factor receptor and cathepsin D expression was not correlated to age, race, stage or Gleason grade. In univariate and multivariate testing epidermal growth factor receptor and cathepsin D were not prognostic markers for disease progression following radical prostatectomy. Conclusions: Immunohistochemical analysis of the biomarkers cathepsin D and epidermal growth factor receptor in radical prostatectomy specimens does not predict disease recurrence. Further biological marker study is needed in clinically localized prostate cancer. C1 WALTER REED ARMY MED CTR,UROL SERV,DEPT SURG,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,UROL SERV,DEPT CLIN INVEST,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,UROL SERV,DEPT PATHOL,WASHINGTON,DC 20307. UNIV N CAROLINA,DEPT PATHOL,CHAPEL HILL,NC. UNIV N CAROLINA,DEPT UROL,CHAPEL HILL,NC. VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PATHOL,RICHMOND,VA 23298. RP Moul, JW (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,CTR PROSTATE DIS RES,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. FU NCI NIH HHS [R01-CA 58126] NR 33 TC 22 Z9 23 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD MAR PY 1996 VL 155 IS 3 BP 982 EP 985 DI 10.1016/S0022-5347(01)66362-6 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA TU668 UT WOS:A1996TU66800049 PM 8583622 ER PT J AU Gorin, DR Cordts, PR LaMorte, WW Menzoian, JO AF Gorin, DR Cordts, PR LaMorte, WW Menzoian, JO TI The influence of wound geometry on the measurement of wound healing rates in clinical trials SO JOURNAL OF VASCULAR SURGERY LA English DT Article ID VENOUS LEG ULCERS AB Purpose: The comparison of wound healing rates in clinical trials presents a challenging problem. Wound healing typically has been expressed as a change in area over time or a percent change in area over time. These methods are inaccurate, however, when applied to wounds of varying size and shape. A relatively small amount of healing in a large wound will produce a greater change in area than in a smaller wound. Conversely, measurement of the percent change in area of a wound will tend to exaggerate the healing rates of smaller wounds. A method of calculating average linear healing of the wound edge toward the center of the wound has been proposed that should not be influenced by wound size: D = Delta A divided by (P) over bar, where D = linear healing, Delta A = change in area, and (P) over bar = mean perimeter. The purpose of this study was to examine linear healing of the wound edge as a method of measuring wound healing in clinical trials. Methods: We observed 39 patients with venous stasis ulcers. The area, perimeter, length, and width of each wound were calculated with computerized planimetry. Change in area per day and linear healing rate of the wound edge per day were calculated. Multiple linear regression analysis was used to explore factors that influence wound healing as measured by these methods. Results: The change in area per day was significantly and independently influenced by initial area (p < .0001), perimeter (p < .0001), length (p < .00055), and width (p < .0175). Linear healing per day was not influenced by any geometric variable, including area, perimeter, length, width, and ratio of width to length. Conclusion: Linear healing per day is a valid means of comparing wound healing rates in wounds of different dimensions. Linear healing per unit of time should be preferred to measurements of change in wound area to quantify wound healing rates in clinical trials. C1 BOSTON UNIV,SCH MED,DEPT SURG,DIV VASC SURG,BOSTON,MA 02215. TRIPLER ARMY MED CTR,DEPT VASC SURG,HONOLULU,HI 96859. NR 7 TC 47 Z9 47 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD MAR PY 1996 VL 23 IS 3 BP 524 EP 528 DI 10.1016/S0741-5214(96)80021-8 PG 5 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA TZ116 UT WOS:A1996TZ11600020 PM 8601898 ER PT J AU Scheffner, NW Borgman, LE Mark, DJ AF Scheffner, NW Borgman, LE Mark, DJ TI Empirical simulation technique based storm surge frequency analyses SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article AB This paper describes theory and application of the empirical simulation technique (EST), a statistical procedure for simulating time series and frequency-of-occurrence relationships for nondeterministic multiparameter systems. Procedures described are applied to a storm surge analysis for tropical events along the coast of Delaware. The approach involves the numerical simulation of historical events, the analysis of the parameters associated with each event, the application of the EST to that data, and the generation of frequency-of-occurrence relationships for 40 locations within the study area. The development of the input data set of descriptive storm parameters and their respective responses require the use of planetary boundary layer and very large domain hydrodynamic modeling techniques. Development of this input database is described herein. Implementation of the EST is based on N repetitions of T-year simulations; therefore, mean-value frequency relationships are computed and assigned confidence limits such that probability of occurrence is defined with error band estimates. Accuracy of the approach is presented and advantages of the technique over the traditional joint probability method are demonstrated. C1 UNIV WYOMING,LARAMIE,WY 82071. RP Scheffner, NW (reprint author), USA,ENGINEER WATERWAYS EXPT STN,COASTAL ENGN RES CTR,VICKSBURG,MS 39180, USA. NR 13 TC 21 Z9 22 U1 0 U2 2 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD MAR-APR PY 1996 VL 122 IS 2 BP 93 EP 101 DI 10.1061/(ASCE)0733-950X(1996)122:2(93) PG 9 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA TY107 UT WOS:A1996TY10700005 ER PT J AU Tzikas, TL Burgess, LPA Pickett, BP Brammer, RE Vossoughi, J AF Tzikas, TL Burgess, LPA Pickett, BP Brammer, RE Vossoughi, J TI Wound healing: Effects of closing tension, Zyplast(TM), and platelet-derived growth factor SO LARYNGOSCOPE LA English DT Article ID SMOOTH-MUSCLE CELLS; FACTOR-BETA; RATS; ACTIVATION AB Previous studies have shown that beginning 5 to 7 days from wounding, the tensile strength of wounds closed under tension in rats is significantly higher than the tensile strength of wounds closed without tension. This study evaluated the effects of increased closing tension, zyplast implant (ZI), and human recombinant platelet-derived growth factor (PDGF) on the tensile strength of wounds, Six groups of 12 rats each were divided into two main subsets: wounds were closed without tension in three groups and with high tension of approximately 100 g in the three other groups, In both no-tension and high-tension groups, one subgroup received no intervention (controls), one subgroup received ZI (zyplast controls), and one subgroup received ZI-PDGF (ZI used as a carrier for PDGF), Healing was evaluated by tensile strength determinations at 5 days. For the controls, wounds closed under tension showed a trend toward higher tensile strength, but statistical significance was not reached, Compared with controls, tensile strength was 45% lower in the wounds with ZI and closure with tension (P = .0063) and 38% lower in the wounds with ZI and closure without tension (P = .007). Treatment with ZI-PDGF resulted in 69% higher tensile strengths (P = .049) as compared with ZI controls for wounds closed with tension, This study demonstrated the beneficial effect of PDGF in accelerating healing in wounds closed under tension. Although ZI was able to deliver PDGF to the wound, the use of this substance as a carrier is questioned since it was detrimental to healing. C1 KELLER ARMY COMMUNITY HOSP,DEPT OTOLARYNGOL HEAD & NECK SURG,W POINT,NY. TRIPLER ARMY MED CTR,DEPT OTOLARYNGOL HEAD & NECK SURG,HONOLULU,HI 96859. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. ST JOHNS HOSP,DEPT OTOLARYNGOL HEAD & NECK SURG,DETROIT,MI. UNIV DIST COLUMBIA,ENGN RES INST,WASHINGTON,DC. NR 28 TC 3 Z9 3 U1 1 U2 1 PU LARYNGOSCOPE CO PI ST LOUIS PA 10 S BROADWAY 14TH FLOOR, ST LOUIS, MO 63102-1741 SN 0023-852X J9 LARYNGOSCOPE JI Laryngoscope PD MAR PY 1996 VL 106 IS 3 BP 322 EP 327 PN 1 PG 6 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA UM977 UT WOS:A1996UM97700015 PM 8614197 ER PT J AU Byrd, JC Edenfield, WJ Dow, NS Aylesworth, C Dawson, N AF Byrd, JC Edenfield, WJ Dow, NS Aylesworth, C Dawson, N TI Extramedullary myeloid cell tumors in myelodysplastic-syndromes: Not a true indication of impending acute myeloid leukemia SO LEUKEMIA & LYMPHOMA LA English DT Article DE extramedullary myeloid cell tumor; neural cell adhesion molecule; myelodysplastic syndrome; granulocytic sarcoma; leukemia cutis ID ACUTE MYELOMONOCYTIC LEUKEMIA; ACUTE MYELOGENOUS LEUKEMIA; GRANULOCYTIC SARCOMA; ADHESION MOLECULE; CUTIS; CHLOROMA; INVOLVEMENT; CHILDREN; NCAM AB The purpose of this report is to record a patient with myelodysplastic syndrome (MDS) associated acute myelogenous leukemia (AML) and leukemia cutis who had blast expression of the neural cell adhesion molecule (NCAM) and to review the world literature on prognostic implications of extramedullary myeloid cell tumors (granulocytic sarcoma, myeloblastoma, chloroma and leukemia cutis) in MDS and MDS associated AML. Case report and world literature from January 1965-January 1994 for all cases of MDS-associated extramedullary myeloid cell tumors (EMT) is reviewed, and the first patient with EMT, MDS associated AML and blast expression of NCAM is described. There have been 46 cases of MDS associated EMT previously reported. 32 cases occurred in the absence of AML. AML developed in 47% of these patients at a mean of 38 weeks from initial EMT. Of the patients not developing AML, median survival from initial EMT was 11 weeks. Nine patients received chemotherapy at the time of EMT and had a median survival of 36 weeks. The median survival for patients receiving conservative therapy for EMT was 48 weeks. Patients (n = 15) with EMT and MDS associated AML had a poor outcome regardless of therapy with a median survival of 11 weeks. Unlike other forms of isolated EMT, MDS associated EMT is not always a forerunner of AML. Premature induction therapy for MDS associated EMT does not appear to prolong survival. EMT in the setting of MDS associated AML is associated with a poor prognosis despite aggressive chemotherapy. Blast expression of NCAM may prove to be a risk factor for EMT in MDS associated AML. C1 WALTER REED ARMY MED CTR,DEPT INTERNAL MED,DIV HEMATOL ONCOL,WASHINGTON,DC 20307. NR 50 TC 46 Z9 47 U1 0 U2 4 PU HARWOOD ACAD PUBL GMBH PI READING PA C/O STBS LTD, PO BOX 90, READING, BERKS, ENGLAND RG1 8JL SN 1042-8194 J9 LEUKEMIA LYMPHOMA JI Leuk. Lymphoma PD MAR PY 1996 VL 21 IS 1-2 BP 153 EP 159 DI 10.3109/10428199609067593 PG 7 WC Oncology; Hematology SC Oncology; Hematology GA TX941 UT WOS:A1996TX94100022 PM 8907283 ER PT J AU Pearton, SJ Abernathy, CR Ren, F Shul, RJ Kilcoyne, SP HagerottCrawford, M Zolper, JC Wilson, RG Schwartz, RG Zavada, JM AF Pearton, SJ Abernathy, CR Ren, F Shul, RJ Kilcoyne, SP HagerottCrawford, M Zolper, JC Wilson, RG Schwartz, RG Zavada, JM TI Process development for III-V nitrides SO MATERIALS SCIENCE AND ENGINEERING B-SOLID STATE MATERIALS FOR ADVANCED TECHNOLOGY LA English DT Article DE III-V nitrides; GaN; wet etching; dry etching; Ohmic contacts ID GALLIUM NITRIDE; HETEROJUNCTION; GROWTH; CARBON; FILMS; GAAS AB Advances in GaN-based electronic and photonic devices requires improved patterning methods, better Ohmic contacts and higher p-type doping levels. In this paper, new developments in dry and wet etching, Ohmic contacts and epitaxial growth of III-V nitrides are reported. We find that high ion density plasmas produce etch rates up to a factor of ten higher than conventional reactive ion etching using the same Cl-2-based chemistries. Similarly, a new wet etch for AIN has been discovered. These new processes make possible devices such as microdisk laser structures and GaAs/AlGaAs heterojunction bipolar transistors with improved InN Ohmic contacts. C1 AT&T BELL LABS,MURRAY HILL,NJ 07974. SANDIA NATL LABS,ALBUQUERQUE,NM 87185. HUGHES RES LABS,MALIBU,CA 90265. USA,RES OFF,RES TRIANGLE PK,NC 27709. RP Pearton, SJ (reprint author), UNIV FLORIDA,GAINESVILLE,FL 32611, USA. NR 37 TC 4 Z9 4 U1 1 U2 2 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0921-5107 J9 MAT SCI ENG B-SOLID JI Mater. Sci. Eng. B-Solid State Mater. Adv. Technol. PD MAR PY 1996 VL 38 IS 1-2 BP 138 EP 146 DI 10.1016/0921-5107(95)01516-7 PG 9 WC Materials Science, Multidisciplinary; Physics, Condensed Matter SC Materials Science; Physics GA UN289 UT WOS:A1996UN28900022 ER PT J AU Scheidler, M AF Scheidler, M TI Smoothness of the scalar coefficients in representations of isotropic tenser-valued functions SO MATHEMATICS AND MECHANICS OF SOLIDS LA English DT Article ID H(A)=ALPHA-I+BETA-A+GAMMA-A(2) AB For a three-dimensional space, an isotropic tenser-valued function Phi of a symmetric tensor A has the representation Phi(A) = alpha(A)I + beta(A)A + gamma(A)A(2), where the coefficients alpha, beta, gamma are isotropic sealar-valued functions. It is known that these coefficients may fail to be as smooth as Phi at those tensors A that do not have three distinct eigenvalues. Serrin and Man determined conditions on the smoothness of Phi that guarantee the existence of continuous coefficients. We give a different proof of their results and also determine conditions on Phi that guarantee the existence of continuously differentiable coefficients. RP Scheidler, M (reprint author), USA,RES LAB,WEAPONS TECHNOL DIRECTORATE,ABERDEEN PROVING GROUND,MD 21005, USA. NR 19 TC 5 Z9 5 U1 0 U2 0 PU SAGE SCIENCE PRESS PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 SN 1081-2865 J9 MATH MECH SOLIDS JI Math. Mech. Solids PD MAR PY 1996 VL 1 IS 1 BP 73 EP 93 PG 21 WC Materials Science, Multidisciplinary; Mathematics, Interdisciplinary Applications; Mechanics SC Materials Science; Mathematics; Mechanics GA VV729 UT WOS:A1996VV72900005 ER PT J AU Little, SF Novak, JM Lowe, JR Leppla, SH Singh, Y Klimpel, KR Lidgerding, BC Friedlander, AM AF Little, SF Novak, JM Lowe, JR Leppla, SH Singh, Y Klimpel, KR Lidgerding, BC Friedlander, AM TI Characterization of lethal factor binding and cell receptor binding domains of protective antigen of Bacillus anthracis using monoclonal antibodies SO MICROBIOLOGY-UK LA English DT Article DE Bacillus anthracis; protective antigen; epitope mapping ID ADENYLATE-CYCLASE; TOXIN ACTIVITY; EXPRESSION; COMPONENT; TOXICITY; GROWTH; ASSAY AB Lethal toxin from Bacillus anthracis is composed of protective antigen (PA) and lethal factor (LF). Anti-PA mAbs that neutralized lethal toxin activity, either in vivo or in vitro, identified three non-overlapping antigenic regions on PA. Two distinct antigenic regions were recognized by the four mAbs that neutralized lethal toxin activity by inhibiting the binding of I-125-LF to cell-bound PA. Mapping showed that one mAb, 1G3(PA63), recognized an epitope on a 17 kDa fragment located between amino acid residues Ser-168 and Phe-314. The three other mAbs, ZD3(PA), ZD5(PA) and 10D2(PA), recognized an epitope between amino acids IIe-581 and Asn-601. A single antigenic region was recognized by the three mAbs, 3B6(PA), 14B7(PA) and 10E10(PA63), that inhibited binding of I-125-PA to cells. This region was located between amino acids Asp-671 and IIe-721. These results confirm previously defined functional domains of PA and suggest that LF may interact with two different sites on PA to form lethal toxin. C1 NIDR,MICROBIAL ECOL LAB,BETHESDA,MD 20892. RP Little, SF (reprint author), USA,MED RES INST INFECT DIS,FREDERICK,MD 21702, USA. NR 31 TC 92 Z9 95 U1 0 U2 3 PU SOC GENERAL MICROBIOLOGY PI READING PA HARVEST HOUSE 62 LONDON ROAD, READING, BERKS, ENGLAND RG1 5AS SN 1350-0872 J9 MICROBIOL-UK JI Microbiology-(UK) PD MAR PY 1996 VL 142 BP 707 EP 715 PN 3 PG 9 WC Microbiology SC Microbiology GA TZ852 UT WOS:A1996TZ85200028 PM 8868446 ER PT J AU Barto, WT AF Barto, WT TI Alexander the Great, the Gordian knot, and the problem of multiplicity in the military justice system SO MILITARY LAW REVIEW LA English DT Article RP Barto, WT (reprint author), USA,JUDGE ADVOCATE GEN SCH,CRIMINAL LAW DEPT,CHARLOTTESVILLE,VA 22901, USA. NR 16 TC 2 Z9 2 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 1996 VL 152 BP 1 EP 32 PG 32 WC Law SC Government & Law GA WC130 UT WOS:A1996WC13000001 ER PT J AU Warren, CML AF Warren, CML TI Operational law - A concept matures SO MILITARY LAW REVIEW LA English DT Article ID UNITED-STATES; FORCES RP Warren, CML (reprint author), USA,JUDGE ADVOCATE GEN CORPS,WASHINGTON,DC, USA. NR 84 TC 1 Z9 1 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 1996 VL 152 BP 33 EP 73 PG 41 WC Law SC Government & Law GA WC130 UT WOS:A1996WC13000002 ER PT J AU Stahl, PM AF Stahl, PM TI The new law on department of defense personnel missing as a result of hostile action SO MILITARY LAW REVIEW LA English DT Article RP Stahl, PM (reprint author), USA,JUDGE ADVOCATE GEN CORPS,WASHINGTON,DC, USA. NR 24 TC 3 Z9 3 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 1996 VL 152 BP 75 EP 177 PG 103 WC Law SC Government & Law GA WC130 UT WOS:A1996WC13000003 ER PT J AU Knuth, TE AF Knuth, TE TI The peacetime trauma experience of US Army surgeons: Another call for collaborative training in Civilian Trauma Centers SO MILITARY MEDICINE LA English DT Article ID GULF-WAR; READINESS; CARE; ATLS AB Objective: To document the ongoing trauma experience of U.S. Army surgeons during peacetime clinical practice. Methods: Surveys were mailed to the trauma directors of military surgical services worldwide. Questions focused on numbers of operative cases and availability of trauma resources. Laparotomy, thoracotomy, and vascular repair for trauma were considered index cases and simple means were computed based on numbers of cases per general surgeon. Results: Seventy percent of worldwide Army surgical services responded to the survey. In 1992, on the average, a general surgeon in the Army performed 1.3 trauma laparotomies, 0.3 thoracotomies, and 0.3 vascular repairs for trauma. Only 6 of 28 surgical services had an organized ''trauma team,'' 3 held regular trauma conferences, and 1 service kept a registry and could calculate an average injury severity score. Conclusions: Our data support perceptions concerning lack of an ongoing trauma experience for military surgeons and reinforces the need for collaborative education and training in busy civilian trauma centers, A regional approach is suggested as a viable solution. RP Knuth, TE (reprint author), UNIFORMED SERV UNIV HLTH SCI,EISENHOWER ARMY MED CTR,DEPT SURG,FT GORDON,GA 30905, USA. NR 21 TC 11 Z9 11 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 1996 VL 161 IS 3 BP 137 EP 142 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA UA236 UT WOS:A1996UA23600003 PM 8637640 ER PT J AU Wittich, AC Salminen, ER Hardin, EL Desantis, RA AF Wittich, AC Salminen, ER Hardin, EL Desantis, RA TI Uterine packing in the combined management of obstetrical hemorrhage SO MILITARY MEDICINE LA English DT Article ID SEVERE POSTPARTUM HEMORRHAGE AB Uterine packing to control obstetrical hemorrhage has been generally discouraged over the past several decades, Intractable uterine hemorrhage postpartum or following an abortion is an extremely vexing management problem for the physician and continues to be a leading cause of maternal mortality, Uterine packing should be considered as a presurgical management tool after lacerations of the lower genital tract, uterine rupture, or retained products have been ruled out and when conventional therapy fails to control uterine hemorrhage, We describe two obstetrical patients with intractable uterine hemorrhage who were managed with uterine packing in combination with other methods of therapy, Causes of obstetrical hemorrhage and techniques of packing the uterus are discussed. RP Wittich, AC (reprint author), TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,HONOLULU,HI 96859, USA. NR 15 TC 9 Z9 9 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 1996 VL 161 IS 3 BP 180 EP 182 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA UA236 UT WOS:A1996UA23600016 PM 8637653 ER PT J AU Dillingham, TR Spellman, NT Chang, AS AF Dillingham, TR Spellman, NT Chang, AS TI Trigeminal motor nerve conduction: Deep temporal end mylohyoid nerves SO MUSCLE & NERVE LA English DT Article DE nerve conduction; mylohyoid nerve; electrodiagnosis; deep temporal nerve; cranial nerve; trigeminal nerve ID INFERIOR ALVEOLAR NERVE; NEUROPATHY; INJURY AB This article describes nerve conduction studies of the deep temporal nerve (DTN) and the mylohyoid nerve (MHN) motor branches of the trigeminal nerve, These nerves were stimulated intraorally with a pediatric surface stimulator. Compound muscle action potentials were recorded over the temporalis and mylohyoid muscles with surface electrodes, Forty-two subjects were studied, In all subjects the MHN response was elicited bilaterally, giving an upper latency limit of 2.3 ms, The mean MHN amplitude was 4.9 mV (SD = 1.8 mV, minimum = 1.3 mV), The maximal side-to-side latency difference was 0.4 ms, and the maximal side-to-side amplitude difference was 2.2 mV. The DTN response was only elicited bilaterally in 25 (60%) subjects. The average DTN latency was 2.1 ms (SD = 0.3, maximum = 2.7 ms), The average DTN amplitude was 4.3 mV (SD = 2.0, minimum = 0.3 mV), The MHN responses were the least technically demanding, and were more consistently elicited than the DTN responses, These nerve conduction techniques should prove useful in patients with trigeminal nerve disorders. (C) 1996 John Wiley & Sons, Inc. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 34 TC 4 Z9 4 U1 0 U2 0 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0148-639X J9 MUSCLE NERVE JI Muscle Nerve PD MAR PY 1996 VL 19 IS 3 BP 277 EP 284 DI 10.1002/mus.880190302 PG 8 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA TW689 UT WOS:A1996TW68900002 PM 8606690 ER PT J AU Byrnes, RB Healey, AJ McGhee, RB Nelson, ML Kwak, SH Brutzman, DP AF Byrnes, RB Healey, AJ McGhee, RB Nelson, ML Kwak, SH Brutzman, DP TI The rational behavior software architecture for intelligent ships SO NAVAL ENGINEERS JOURNAL LA English DT Article AB The solutions to the power projection, transportation, and operational needs of the Navy as it faces the 21st century must account for reduced manning levels. This leads naturally to increased use of computers, automation, and intelligent systems in the concept and design of the next generation of ships. In addition to the acknowledged hardware needs, the problem of autonomic and autonomous control of shipboard systems and missions are amenable to and will, in fact, require software solutions. Despite current technology, large, reliable software systems are difficult to achieve because correctness in requirements analysis, design, implementation, testing, modification, and maintenance of software are difficult. Software is also difficult to quantize and display; hence, the effort and costs involved in its development are easily underestimated. This paper describes an approach to the problem of providing structure, in the form of a software architecture, to the software performing autonomous control of missions and their related tasks. In concert with the need to reduce complexity, the architecture must support simple, rapid reconfiguration of code should vehicle capabilities or mission requirements change. Building upon recent efforts with control of Autonomous Underwater Vehicles (AUVs), we propose a tri-level control system architecture called the Rational Behavior Model (RBM) as an approach to autonomous and autonomic control of surface ship missions and systems. RP USA, RES LAB, SOFTWARE TECHNOL BRANCH, WASHINGTON, DC 20310 USA. NR 39 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC NAVAL ENG INC PI ALEXANDRIA PA 1452 DUKE STREET, ALEXANDRIA, VA 22314-3458 USA SN 0028-1425 EI 1559-3584 J9 NAV ENG J JI Nav. Eng. J. PD MAR PY 1996 VL 108 IS 2 BP 43 EP 55 PG 13 WC Engineering, Marine; Engineering, Civil; Oceanography SC Engineering; Oceanography GA UW755 UT WOS:A1996UW75500004 ER PT J AU Newmann, RE Nishimoto, PW AF Newmann, RE Nishimoto, PW TI 1996 human immunodeficiency virus update for the primary care provider SO NURSE PRACTITIONER FORUM-CURRENT TOPICS AND COMMUNICATIONS LA English DT Article ID HIV AB Rapid development and changes in the care of patients with human immunodeficiency virus (HIV) infection will continue, bringing challenge to the nurse in advanced practice (APN) to keep up with those developments. The demand for APNs to provide primary care to many of these patients will be high. By creating working relationships with experts in HIV, APNs will be able to implement these improvements into their clinical care in an expeditious and effective manner. (C) 1996 by W.B. Saunders Company C1 HAWAII PACIFIC UNIV,HONOLULU,HI. UNIV HAWAII MANOA,HONOLULU,HI 96822. RP Newmann, RE (reprint author), TRIPLER ARMY MED CTR,INFECT DIS SERV MCHK DMI,1 JARRETT WHITE RD,HONOLULU,HI 96859, USA. NR 31 TC 1 Z9 1 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 1045-5485 J9 NURS PRACT FORUM JI Nurse Pract. Forum-Curr. Top. Commun. PD MAR PY 1996 VL 7 IS 1 BP 16 EP 22 PG 7 WC Nursing SC Nursing GA UN199 UT WOS:A1996UN19900007 PM 8788659 ER PT J AU Krapohl, GL Larson, E AF Krapohl, GL Larson, E TI The impact of unlicensed assistive personnel on nursing care delivery SO NURSING ECONOMICS LA English DT Article ID EXTENDER MODEL; COST; TIME AB Besieged with fiscal and political constraints in acute care, the addition or substitution of less expensive nursing personnel is quickly gaining popularity. The evolution of nursing care delivery systems in the acute care setting, the factors associated with the increased use of unlicensed assistive personnel, examination and evaluation of the current literature surrounding unlicensed assistive personnel, and recommendations for a future strategy are described. C1 GEORGETOWN UNIV,SCH NURSING,WASHINGTON,DC. RP Krapohl, GL (reprint author), USA,WASHINGTON,DC 20310, USA. NR 67 TC 32 Z9 32 U1 1 U2 1 PU JANNETTI PUBLICATIONS, INC PI PITMAN PA EAST HOLLY AVENUE, BOX 56, PITMAN, NJ 08071-0056 SN 0746-1739 J9 NURS ECON JI Nurs. Econ. PD MAR-APR PY 1996 VL 14 IS 2 BP 99 EP & PG 13 WC Nursing SC Nursing GA UC557 UT WOS:A1996UC55700006 PM 8700267 ER PT J AU Ostrem, ED Fink, BA Hill, RM AF Ostrem, ED Fink, BA Hill, RM TI Contact lens transmissibility: Effects on delivery of oxygen to the cornea SO OPTOMETRY AND VISION SCIENCE LA English DT Article DE contact lens; permeability; modulus of elasticity; tear pump efficiency ID TEAR PUMP EFFICIENCY AB The purpose of this study was to determine the effects of rigid contact lens materials of various permeabilities and identical design on the oxygen shortfall of the human cornea and to explore differences in oxygen delivery to the cornea associated with contact lens materials of different modulus of elasticity values. Measurement of corneal oxygen uptake was performed for six human subjects under three conditions: (1) normal open eye; (2) after the static wear of six materials; and (3) after the dynamic wear of the same six materials. The 6 materials had Dk values that ranged from 0.02 to 127 (cm(2)/s)(ml O-2/ml x mm Hg) and modulus of elasticity values from 1300 to 2200 MPa. Major results include: (1) that the oxygen shortfall of the cornea decreased with increasing lens transmissibility under both static and dynamic conditions, with significant differences (p < 0.001) being demonstrated among materials; and (2) significantly larger differences (p < 0.001) between the static and dynamic condition data were seen for materials of low ok but were not predictable by lens modulus (p = 0.43, r(2) = 0.018). The corneal demand differences between high and low Dk materials are possibly related to changes in corneal oxygen dynamics rather than to differences in tear exchange. RP Ostrem, ED (reprint author), KELLER ARMY HOSP,OPTOMETRY CLIN,W POINT,NY 10996, USA. NR 13 TC 4 Z9 4 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1040-5488 J9 OPTOMETRY VISION SCI JI Optom. Vis. Sci. PD MAR PY 1996 VL 73 IS 3 BP 159 EP 163 DI 10.1097/00006324-199603000-00006 PG 5 WC Ophthalmology SC Ophthalmology GA UD698 UT WOS:A1996UD69800006 PM 8725016 ER PT J AU Butcher, JD Siekanowicz, A Pettrone, F AF Butcher, JD Siekanowicz, A Pettrone, F TI Pectoralis major rupture SO PHYSICIAN AND SPORTSMEDICINE LA English DT Article ID MUSCLE; AVULSION; TENDON AB Rupture of the pectoralis major muscle and tendon, which occurs most frequently among weight lifters but has been reported in many sports, can most often be diagnosed based on the history and physical exam. Surgical intervention for complete ruptures has a clear advantage over conservative therapy. Athletes of all levels can be expected to return to near preinjury levels of participation following surgery and a well-constructed, supervised rehabilitation program, This should involve immobilization followed by range-of-motion exercises and strength training of gradually increasing resistance. C1 KINSTON ORTHOPED & SPORTS MED CTR,KINSTON,NC. GEORGETOWN UNIV,DEPT ORTHOPED,WASHINGTON,DC. RP Butcher, JD (reprint author), DWIGHT D EISENHOWER ARMY MED CTR,DEPT FAMILY MED,FT GORDON,GA, USA. NR 14 TC 1 Z9 1 U1 0 U2 0 PU MCGRAW HILL HEALTHCARE PUBLICATIONS PI MINNEAPOLIS PA 4530 WEST 77TH ST, MINNEAPOLIS, MN 55435-5000 SN 0091-3847 J9 PHYSICIAN SPORTSMED JI Physician Sportsmed. PD MAR PY 1996 VL 24 IS 3 BP 37 EP & PG 6 WC Primary Health Care; Orthopedics; Sport Sciences SC General & Internal Medicine; Orthopedics; Sport Sciences GA TY583 UT WOS:A1996TY58300005 PM 20086975 ER PT J AU Larsen, TB Yuen, DA Malevsky, AV Smedsmo, JL AF Larsen, TB Yuen, DA Malevsky, AV Smedsmo, JL TI Dynamics of strongly time-dependent convection with non-Newtonian temperature-dependent viscosity SO PHYSICS OF THE EARTH AND PLANETARY INTERIORS LA English DT Article ID FREE UPPER BOUNDARY; THERMAL-CONVECTION; EARTHS MANTLE; VARIABLE VISCOSITY; HEAT-TRANSPORT; RHEOLOGY; CREEP; MODELS; EVOLUTION; PLATES AB Numerical simulations of time-dependent Boussinesq convection with a non-Newtonian temperature-dependent rheology have been conducted in wide aspect-ratio boxes for effective Rayleigh numbers, Ra-v, ranging from 3.5 x 10(4) to 1.3 x 10(6). The transition to the chaotic regime for non-Newtonian temperature-dependent viscosity takes place at Ra-v an order of magnitude lower than for purely temperature-dependent viscosity. For viscosity contrasts owing to temperature of O(10(2)), lateral viscosity contrasts generated by the flow are typically of O(10(3)) in the interior with contrasts as large as O(10(6)) in the upper boundary layer. The horizontal Fourier spectra of the temperature field and of the inverse of the viscosity field show that the asymmetry in the flow introduced by a temperature-dependent viscosity is weaker for a non-Newtonian rheology than for a Newtonian rheology. Lithospheric dynamics, such as lubrication of subduction and lithospheric thinning, are greatly facilitated by the effects of stress-softening from non-Newtonian rheology. Weak plumes are slowed down drastically in the middle of their ascent because of the stress-dependent nature of the rheology. Downgoing slabs can be found to be weakened near the middle, and detachment involving pieces of the descending material may take place. The mobility of the stiff upper boundary layer is facilitated by an increase in the vigor of convection, whereas an increase in the viscosity contrast owing to temperature retards the surface mobility. C1 UNIV MINNESOTA, DEPT GEOL & GEOPHYS, MINNEAPOLIS, MN 55415 USA. UNIV MONTREAL, DEPT PHYS, MONTREAL, PQ H3X 2H9, CANADA. UNIV MONTREAL, DEPT COMP SCI, MONTREAL, PQ H3X 2H9, CANADA. RP Larsen, TB (reprint author), UNIV MINNESOTA, MINNESOTA SUPERCOMP INST, ARMY HIGH PERFORMANCE COMP RES CTR, MINNEAPOLIS, MN 55415 USA. NR 46 TC 8 Z9 8 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0031-9201 J9 PHYS EARTH PLANET IN JI Phys. Earth Planet. Inter. PD MAR PY 1996 VL 94 IS 1-2 BP 75 EP 103 DI 10.1016/0031-9201(95)03082-4 PG 29 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA UH065 UT WOS:A1996UH06500005 ER PT J AU Nghiem, SV Kwok, R Kong, JA Shin, RT Arcone, SA Gow, AJ AF Nghiem, SV Kwok, R Kong, JA Shin, RT Arcone, SA Gow, AJ TI An electrothermodynamic model with distributed properties for effective permittivities of sea ice SO RADIO SCIENCE LA English DT Article ID COMPLEX-DIELECTRIC-CONSTANT; MICROWAVE-FREQUENCIES; SCATTERING; FLUCTUATIONS; BRINE; MEDIA; SNOW AB This paper presents a model to calculate the temperature dependence of effective permittivities for sea ice, a heterogeneous medium containing multiphase scatterers. With the strong permittivity fluctuation approach the model accounts for the electrodynamic scattering effect together with the quasi-static characteristics of multiple species and subspecies of inhomogeneities with distributed orientations, sizes, and shapes. Because of a preferential direction in the orientation distribution, the medium is effectively anisotropic. The size distribution is described with a probability density function in terms of normalized volumetric sizes. Scatterer shapes are nonuniform and have a general ellipsoidal form characterized by arbitrary axial ratios of correlation lengths which are related to physical geometries of the scatterers. In this formulation, sea ice consisting of solid ice, liquid brine, and gaseous inclusions is modeled to derive effective permittivities with thermodynamic phase redistribution and structural metamorphism. Theoretical results are in good agreement with experimental data at the C band frequency of 4.8 GHz for saline ice undergoing warming and cooling cycles. A competitive effect between the increase of liquid brine and the shape rounding of ellipsoidal scatterers at increasing temperatures explains the trend observed in measured data. Sensitivities of effective permittivities to structural and physical parameters characterizing sea ice are also studied. C1 USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. MIT,DEPT ELECT ENGN & COMP SCI,CAMBRIDGE,MA 02139. MIT,ELECTR RES LAB,CAMBRIDGE,MA 02139. RP Nghiem, SV (reprint author), CALTECH,JET PROP LAB,4800 OAK GROVE DR,MAIL STOP 300-235,PASADENA,CA 91109, USA. RI Kwok, Ron/A-9762-2008 OI Kwok, Ron/0000-0003-4051-5896 NR 27 TC 16 Z9 18 U1 0 U2 2 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0048-6604 J9 RADIO SCI JI Radio Sci. PD MAR-APR PY 1996 VL 31 IS 2 BP 297 EP 311 DI 10.1029/95RS03429 PG 15 WC Astronomy & Astrophysics; Geochemistry & Geophysics; Meteorology & Atmospheric Sciences; Remote Sensing; Telecommunications SC Astronomy & Astrophysics; Geochemistry & Geophysics; Meteorology & Atmospheric Sciences; Remote Sensing; Telecommunications GA UD849 UT WOS:A1996UD84900007 ER PT J AU Mukherjee, S Mahadik, SP Scheffer, R Correnti, EE Kelkar, H AF Mukherjee, S Mahadik, SP Scheffer, R Correnti, EE Kelkar, H TI Impaired antioxidant defense at the onset of psychosis SO SCHIZOPHRENIA RESEARCH LA English DT Article DE oxyradical; superoxide dismutase; glutathione peroxidase; catalase; (schizophrenia) ID FREE-RADICAL ACTIVITY; VITAMIN-E TREATMENT; TARDIVE-DYSKINESIA; SUPEROXIDE-DISMUTASE; LIPID-PEROXIDATION; GLUTATHIONE-PEROXIDASE; RAT-BRAIN; SCHIZOPHRENIC-PATIENTS; CEREBROSPINAL-FLUID; ALZHEIMERS-DISEASE AB Previous studies found peripheral activities of antioxidant enzymes to be abnormal in schizophrenic patients. It is not understood whether this is integral to the disease process or a result of long-term treatment with neuroleptics. Red blood cell activities of three antioxidant enzymes - superoxide dismutase, glutathione peroxidase, and catalase were therefore examined in 14 drug-naive, first episode patients with a diagnosis of schizophrenia or schizophreniform disorder and 10 normal subjects. The patients had an average duration of psychosis of 4.46 days (SD 2.5). Superoxide dismutase activity was significantly lower in patients than in normal controls, with no difference between the groups in activities of the other two enzymes. Lower superoxide dismutase activity was associated with deterioration of school functioning from childhood to early adolescence and a history of poorer school functioning during early adolescence. These findings indicate a compromised antioxidant defense at the onset of psychosis, and suggest that oxidative injury might contribute to adverse developmental events in the pathogenic cascade of schizophrenia. C1 MED COLL GEORGIA, DEPT PSYCHIAT & HLTH BEHAV, AUGUSTA, GA 30912 USA. VET AFFAIRS MED CTR, PSYCHIAT SERV, AUGUSTA, GA USA. VET AFFAIRS MED CTR, RES SERV, AUGUSTA, GA USA. DWIGHT D EISENHOWER ARMY MED CTR, DEPT PSYCHIAT, FT GORDON, GA USA. FU NIMH NIH HHS [MH-47002, MH-46546] NR 65 TC 60 Z9 60 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0920-9964 EI 1573-2509 J9 SCHIZOPHR RES JI Schizophr. Res. PD MAR PY 1996 VL 19 IS 1 BP 19 EP 26 DI 10.1016/0920-9964(95)00048-8 PG 8 WC Psychiatry SC Psychiatry GA UH084 UT WOS:A1996UH08400002 PM 9147492 ER PT J AU Hilton, JD AF Hilton, JD TI Corps dredge projects exceed $500 million SO SEA TECHNOLOGY LA English DT Article RP Hilton, JD (reprint author), USA,CORPS ENGINEERS,WASHINGTON,DC 20314, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU COMPASS PUBL INC PI ARLINGTON PA SUITE 1000 1117 N 19 ST, ARLINGTON, VA 22209 SN 0093-3651 J9 SEA TECHNOL JI Sea Technol. PD MAR PY 1996 VL 37 IS 3 BP 29 EP 30 PG 2 WC Engineering, Ocean SC Engineering GA UB173 UT WOS:A1996UB17300005 ER PT J AU Dipert, RR AF Dipert, RR TI Reflections on iconicity, representation, and resemblance: Peirce's theory of signs, Goodman on resemblance, and modern philosophies of language and mind SO SYNTHESE LA English DT Article RP Dipert, RR (reprint author), US MIL ACAD,DEPT ENGLISH PHILOSOPHY,W POINT,NY 10996, USA. NR 33 TC 8 Z9 8 U1 0 U2 0 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0039-7857 J9 SYNTHESE JI Synthese PD MAR PY 1996 VL 106 IS 3 BP 373 EP 397 DI 10.1007/BF00413591 PG 25 WC History & Philosophy Of Science; Philosophy SC History & Philosophy of Science; Philosophy GA VK320 UT WOS:A1996VK32000003 ER PT J AU Iwu, MM AF Iwu, MM TI Implementing the biodiversity treaty: How to make international co-operative agreements work SO TRENDS IN BIOTECHNOLOGY LA English DT Article AB The Convention on Biological Diversity provides an international legal framework and multilateral mechanism for the exchange of genetic materials and conservation of biodiversity. The Convention recognizes the sovereign rights of states over their natural resources, and the authority to determine access. The research agreements and legal contracts must address the needs of indigenous people, community rights, sustainable methods of sample collection, compensation and intellectual property issues. Implementation of the articles of the treaty requires not only the formulation of legal agreements and contracts, but also the establishment of meaningful and just collaborations, and functional partnerships between industrialized nations and source countries. C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. RP Iwu, MM (reprint author), UNIV NIGERIA,BIORESOURCES DEV & CONSERVAT PROGRAMME,BOX 3138,NSUKKA,NIGERIA. NR 12 TC 6 Z9 7 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0167-7799 J9 TRENDS BIOTECHNOL JI Trends Biotechnol. PD MAR PY 1996 VL 14 IS 3 BP 78 EP 83 DI 10.1016/0167-7799(96)80927-9 PG 6 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA TZ964 UT WOS:A1996TZ96400004 ER PT J AU Vaughn, DW Hoke, CH Yoksan, S LaChance, R Innis, BL Rice, RM Bhamarapravati, N AF Vaughn, DW Hoke, CH Yoksan, S LaChance, R Innis, BL Rice, RM Bhamarapravati, N TI Testing of a dengue 2 live-attenuated vaccine (strain 16681 PDK 53) in ten American volunteers SO VACCINE LA English DT Article DE live-attenuated vaccines; dengue; clinical trial ID INFECTIONS AB A live-attenuated dengue 2 vaccine (strain 16681 PDK 53) developed at Mahidol University, Thailand was evaluated for safety and immunogenicity by administering 10(4) p.f.u. subcutaneously to ten flavivirus non-immune American volunteers. The vaccine was safe, there were no serious adverse reactions. Eight recipients experienced no or mild side effects. One recipient reported headaches on 7 separate clays. One volunteer, who had a fracture of the humerus 1 day after vaccination requiring surgical repair, experienced generalized malaise with fever (maximum temperature=38.9 degrees C), headache, eye pain and myalgia lasting less than 24 h. The vaccine was highly immunogenic, all recipients developed neutralizing antibody that persisted for two years. Copyright (C) 1996 Published by Elsevier Science Ltd. C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. MAHIDOL UNIV,CTR VACCINE DEV,SALAYA,THAILAND. USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. USA,MED MAT DEV ACT,FREDERICK,MD 21702. RP Vaughn, DW (reprint author), ARMED FORCES RES INST MED SCI,APO,AP 96546, USA. NR 14 TC 73 Z9 75 U1 0 U2 2 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PD MAR PY 1996 VL 14 IS 4 BP 329 EP 336 DI 10.1016/0264-410X(95)00167-Y PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA UG716 UT WOS:A1996UG71600014 PM 8744561 ER PT J AU Pittman, PR Makuch, RS Mangiafico, JA Cannon, TL Gibbs, PH Peters, CJ AF Pittman, PR Makuch, RS Mangiafico, JA Cannon, TL Gibbs, PH Peters, CJ TI Long-term duration of detectable neutralizing antibodies after administration of live-attenuated VEE vaccine and following booster vaccination with inactivated VEE vaccine SO VACCINE LA English DT Article DE Venezuelan Equine Encephalitis (VEE) virus; VEE vaccines; TC-83; C-84 ID EQUINE ENCEPHALITIS-VIRUS; VENEZUELAN AB The US Army successfully developed a live-attenuated Venezuelan Equine Encephalitis (VEE) vaccine, TC-83, in 1961, and subsequently developed a formalin-inactivated vaccine, C-84, in 1974. Initial evaluation of both vaccines was promising, but no long-term safety and immunogenicity data have been reported This study is the first analysis of the long-term safety and immunogenicity of TC-83 and C-84. From January 1976 to December 1990, 821 laboratory workers at the USAMRIID were vaccinated with a single 0.5 mi subcutaneous (s.c.) dose of TC-83; 128 were boosted with a single 0.5 mi s.c. dose of C-84. Eighty-two per cent of vaccinees responded to TC-83 with an 80% plaque reduction neutralization titer (PRNT(80)) of greater than or equal to 1:20. Minor side-effects were noted in 23% of vaccinees. No long-term sequelae were recorded. Kaplan-Meier analysis showed a 60% probability of vaccinees maintaining a PRNT(80) of greater than or equal to 1:20 for 5.5-8 years. C-84 was given to two groups: 76 initial nonresponders to TC-83, Group A, and 52 initial responders to TC-83 whose PRNT(80) became <1:20 over time, Group B. C-84 successfully boosted 76% of Group A and 100% of Group B to a PRNT(80)greater than or equal to 1:20. Kaplan -Meier analysis showed 100% probability of Group B members maintaining a titer of greater than or equal to 1:20 for the duration of follow-up, which, in some cases, exceeded 10 years; while Group A had only a 60% probability of maintaining a titer for 1-2 years. Only minor local reactions to C-84 were noted in 6.3% of vaccinees. We conclude that, although TC-83 is reactogenic, when administered as the primary vaccine and C-84 is administered as a boost, these vaccines provide good long-term immunity and are safe in humans. However, a single dose vaccine that is more immunogenic and less reactogenic is needed. Copyright (C) 1996 Published by Elsevier Science Ltd. C1 USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FT DETRICK,MD 21702. USA,MED RES INST INFECT DIS,BIOMETR & INFORMAT MANAGEMENT DIV,FT DETRICK,MD 21702. RP Pittman, PR (reprint author), USA,MED RES INST INFECT DIS,DIV MED,FT DETRICK,MD 21702, USA. NR 17 TC 120 Z9 121 U1 2 U2 7 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PD MAR PY 1996 VL 14 IS 4 BP 337 EP 343 DI 10.1016/0264-410X(95)00168-Z PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA UG716 UT WOS:A1996UG71600015 PM 8744562 ER PT J AU Liang, MF Chu, YK Schmaljohn, C AF Liang, MF Chu, YK Schmaljohn, C TI Bacterial expression of neutralizing mouse monoclonal antibody Fab fragments to Hantaan virus SO VIROLOGY LA English DT Article ID KOREAN HEMORRHAGIC-FEVER; RENAL SYNDROME; ETIOLOGIC AGENT; DOBRAVA VIRUS; HANTAVIRUS; INFECTION; LIBRARIES; MICE; GLYCOPROTEIN; ANTIGEN AB We amplified by polymerase chain reaction the heavy and light chain antibody genes of two mouse hybridomas secreting neutralizing monoclonal antibodies (MAbs) to the G1 or G2 envelope proteins of Hantaan virus, cloned them into the phagemid vector pComb3, and expressed them in bacteria to yield Fab fragments. Expressed Fab fragments had the same antigenic specificities for Hantaan and Seoul viruses as the complete parent MAbs and were able to neutralize Hantaan virus in plaque-reduction neutralization assays. The authentic MAb to G2 (HCO2) could passively protect hamsters from challenge with Hantaan virus when neutralizing antibody titers of at least 1:10 were detected in the animals' sera just prior to challenge. In contrast, although 1:10 neutralization titers were also detected in hamsters receiving passively transferred, Escherichia coli-expressed HCO2 Fab, these animals were not protected from infection with Hantaan virus. Similarly, passive transfer of the HCO2 MAb on Days 1 through 4 after infection prevented antigen deposition in hamster lungs and kidneys but passive transfer of the recombinant HCO2 Fab did not. The results suggest that although neutralization by IgG antibodies correlates with protection in hamsters, the same may not be true for neutralizing Fab fragments. (C) 1996 Academic Press, Inc. C1 USA,MED RES INST INFECT DIS,DIV VIROL,FREDERICK,MD 21702. NR 36 TC 26 Z9 29 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0042-6822 J9 VIROLOGY JI Virology PD MAR 1 PY 1996 VL 217 IS 1 BP 262 EP 271 DI 10.1006/viro.1996.0113 PG 10 WC Virology SC Virology GA TY211 UT WOS:A1996TY21100027 PM 8599211 ER PT J AU Rossell, CR Gorsira, B AF Rossell, CR Gorsira, B TI Assessment of condition and availability of active red-cockaded woodpecker cavities SO WILDLIFE SOCIETY BULLETIN LA English DT Article DE cavity use; nesting; Picoides borealis; red-cockaded woodpecker; roosting ID COMPETITION; SELECTION; BEHAVIOR; AGE AB We examined the condition and general characteristics of active red-cockaded woodpecker (Picoides borealis) cavities in relation to species use. Results indicated that red-cockaded woodpeckers and southern flying squirrels (Glaucomys volans selected different types of cavities (P < 0.001). Red-cockaded woodpeckers nested exclusively in cavities with normal entrances and chambers, whereas flying squirrels selected cavities with enlarged chambers (P < 0.001), regardless of entrance size (P = 0.086). C1 XVIII AIRBORNE & CORPS HEADQUARTERS,DIRECTORATE PUBL WORKS & ENVIRONM,ENDANGERED SPECIES BRANCH,FT BRAGG,NC 28307. NR 22 TC 0 Z9 0 U1 1 U2 1 PU WILDLIFE SOC PI BETHESDA PA 5410 GROSVENOR LANE, BETHESDA, MD 20814-2197 SN 0091-7648 J9 WILDLIFE SOC B JI Wildl. Soc. Bull. PD SPR PY 1996 VL 24 IS 1 BP 21 EP 24 PG 4 WC Biodiversity Conservation SC Biodiversity & Conservation GA UG779 UT WOS:A1996UG77900007 ER PT J AU Bridges, TS Farrar, JD Gamble, EV Dillon, TM AF Bridges, TS Farrar, JD Gamble, EV Dillon, TM TI Intraspecific density effects in Nereis (Neanthes) arenaceodentata Moore (Polychaeta: Nereidae) SO JOURNAL OF EXPERIMENTAL MARINE BIOLOGY AND ECOLOGY LA English DT Article DE competition; density dependence; soft substrate; territorial behavior ID ROCKY INTERTIDAL COMMUNITY; INFAUNAL POLYCHAETE; POPULATION-DENSITY; VIRENS SARS; LIFE-HISTORY; GROWTH-RATE; COMPETITION; SEDIMENT; FOOD; ORGANIZATION AB Effects of intraspecific density on Neanthes arenaceodentata Moore were examined under laboratory conditions by rearing animals for 28 days, in the presence of sediment, at densities of 230, 575, 1150, and 1730 worms/m(2). The lowest density examined in this study was similar to the mean reported field density for N. arenaceodentata. Food was allocated to each beaker on a per worm basis to focus the experiment on competition for space. Individual worm growth increased with increasing density. This result contrasts with other studies of intraspecific density effects in this species conducted in the absence of sediment where negative effects on growth were observed. Estimated individual dry weight and ash free dry weight of worms in the highest density treatment were significantly greater (13 and 18%, respectively) than worms in the lowest density treatment at the end of 28 days of growth. This increase in growth was associated with a decrease in the number of ovigerous females, suggesting a delay in reproductive development, and an increase in the number of worms regenerating posterior segments, suggesting an increase in the number of aggressive encounters. At the end of the 28 day growth experiment, mated pairs were established in separate beakers. Intraspecific density did not have a lasting effect on time to egg deposition and juvenile emergence or fecundity. The benefits of larger body size at higher densities may include the fact that larger worms are more successful at defending territories and finding mates. The results of this study emphasize the importance of sediment as a structuring agent in soft substratum habitats and the potential for complex density dependent effects. C1 ASCI CORP,VICKSBURG,MS. RP Bridges, TS (reprint author), USA,ENGINEER WATERWAYS EXPT STN,ES-F,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 71 TC 18 Z9 18 U1 0 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0981 J9 J EXP MAR BIOL ECOL JI J. Exp. Mar. Biol. Ecol. PD FEB 29 PY 1996 VL 195 IS 2 BP 221 EP 235 DI 10.1016/0022-0981(95)00104-2 PG 15 WC Ecology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA UA180 UT WOS:A1996UA18000005 ER PT J AU Ratto, JA Chen, CC Blumstein, RB AF Ratto, JA Chen, CC Blumstein, RB TI Phase behavior study of chitosan polyamide blends SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article ID POLYMER BLENDS; SOLID-STATE; CELLULOSE; MEMBRANE; PERMEABILITY; ALCOHOL); FILMS AB Blends of chitosan with strongly crystalline polyamides (nylon-4 and nylon-6) and weakly crystalline polyamides (caprolactam/laurolactam and Zytel(R)) were investigated. Phase behavior, morphology, interactions with water, mechanical properties, and catalytic reactivity were studied. Films were made from formic acid solutions with the chitosan concentrations ranging from 5% to 95% (w/w). The 80% deacetylated chitosan is in the salt, neutral, or copper chelate form. All the blends have higher relative water contents than does the pure chitosan. Dry neutral chitosan shows a relaxation centered at approximately 90 degrees C which is attributed to local motion. The phase behavior of the blends is influenced by preparation conditions such as the drying temperature. Characterization of blends by differential scanning calorimetry (DSC) and dynamic mechanical analysis (DMA) suggests partial miscibility of chitosan with nylon-4 and lack of miscibility in the remaining cases. Blending with nylon-4 enhances mechanical properties with marked antiplasticization in blends containing 90% chitosan. Catalytic activity of the chitosan is enhanced by blending with nylon-4. Salt and neutral forms of chitosan appear to be equally effective. (C) 1996 John Wiley & Sons, Inc. C1 UNIV MASSACHUSETTS,POLYMER PROGRAM,LOWELL,MA 01854. USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. NR 41 TC 55 Z9 55 U1 1 U2 13 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0021-8995 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD FEB 28 PY 1996 VL 59 IS 9 BP 1451 EP 1461 DI 10.1002/(SICI)1097-4628(19960228)59:9<1451::AID-APP13>3.0.CO;2-1 PG 11 WC Polymer Science SC Polymer Science GA TR388 UT WOS:A1996TR38800013 ER PT J AU Gorbunov, NV Osipov, AN Sweetland, MA Day, BW Elsayed, NM Kagan, VE AF Gorbunov, NV Osipov, AN Sweetland, MA Day, BW Elsayed, NM Kagan, VE TI NO-redox paradox: Direct oxidation of alpha-tocopherol and alpha-tocopherol-mediated oxidation of ascorbate SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS LA English DT Article ID LOW-DENSITY-LIPOPROTEIN; NITRIC-OXIDE; VITAMIN-E; ANTIOXIDANTS; INHIBITION; ESR AB Nitric oxide (NO) can act as both a pro- or an antioxidant, yielding either cytotoxic or protective effects, respectively. The previously unrecognized redox interactions of NO with antioxidants, and not solely its well-known reactions with oxygen radicals, peroxyl radicals and transition metal centers, may be essential for its dual mechanisms in cells. Since the alpha-tocopherol/ascorbate redox cycle is central to antioxidant protection, we studied the direct effects of NO on alpha-tocopherol, ascorbate and combinations thereof in aqueous, micellar environments using ESR spectral and HPLC quantitative techniques. We found that NO does not directly oxidize ascorbate under anaerobic conditions. alpha-Tocopherol, however, in the presence of NO and under anaerobic conditions, was oxidized to the alpha-tocopheroxyl radical. Under conditions where NO oxidized alpha-tocopherol, the subsequent production of the alpha-tocopheroxyl radical depleted ascorbate, yielding the semidehydroascorbyl radical and regenerating alpha-tocopherol. Thus, NO interacts with the redox cycle involving alpha-tocopherol and ascorbate in a pro-oxidant manner. (C) 1996 Academic Press, Inc. C1 UNIV PITTSBURGH,INST CANC,PITTSBURGH,PA 15238. UNIV PITTSBURGH,DEPT ENVIRONM & OCCUPAT HLTH,PITTSBURGH,PA 15238. UNIV PITTSBURGH,DEPT PHARMACEUT SCI,PITTSBURGH,PA 15238. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT RESP RES,WASHINGTON,DC 20307. FU NHLBI NIH HHS [HL 51469] NR 27 TC 24 Z9 24 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0006-291X J9 BIOCHEM BIOPH RES CO JI Biochem. Biophys. Res. Commun. PD FEB 27 PY 1996 VL 219 IS 3 BP 835 EP 841 DI 10.1006/bbrc.1996.0319 PG 7 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA TZ799 UT WOS:A1996TZ79900027 PM 8645266 ER PT J AU Cheong, DW Kim, WH Samuelson, LA Kumar, J Tripathy, SK AF Cheong, DW Kim, WH Samuelson, LA Kumar, J Tripathy, SK TI Oriented Z-type Langmuir-Blodgett films from a soluble asymmetrically substituted polydiacetylene SO MACROMOLECULES LA English DT Article ID 2ND HARMONIC-GENERATION; 2ND-HARMONIC GENERATION; MOLECULAR-ORIENTATION; MULTILAYERS; POLYMER; SPECTROSCOPY AB A soluble, asymmetric polydiacetylene has been shown to form stable monolayers at the air-water interface of a Langmuir trough. The monolayers of this unconventional amphiphilic polymer could be repeatedly deposited onto hydrophobic substrates during every upstroke cycle of the vertical dipping method to form uniform Z-type multilayers. Characterization of the precise orientation of the polymer main chain has been carried out to determine the spatial correlation between the nonlinear optical chromophore responsible for second-order nonlinear optical properties and the backbone. Polarized UV/vis and IR spectroscopic studies indicate a preferential orientation of the main chain along the dipping direction with a mean fluctuation of +/-30 degrees between director axis and chain trajectories. Polarization-dependent second-harmonic generation (SHG) in multilayers indicates a high degree of orientational anisotropy of the backbone. As expected, SHG intensities increase with the number of layers due to the noncentrosymmetric Z-type structure. The second-order nonlinear coefficient (d(33)) was estimated to be 1.52 pm/V at 1064 nm of Nd:YAG laser after correcting for absorption. Surface characterization and alignment of the extended chain backbones is further established using atomic force microscopy (AFM). C1 USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760. UNIV MASSACHUSETTS,DEPT CHEM & PHYS,CTR ADV MAT,LOWELL,MA 01854. NR 35 TC 13 Z9 15 U1 0 U2 6 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD FEB 26 PY 1996 VL 29 IS 5 BP 1416 EP 1421 DI 10.1021/ma951214h PG 6 WC Polymer Science SC Polymer Science GA TY139 UT WOS:A1996TY13900006 ER PT J AU LaBorde, JB Bates, HK Dacre, JC Young, JF AF LaBorde, JB Bates, HK Dacre, JC Young, JF TI Developmental toxicity of sarin in rats and rabbits SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH LA English DT Article AB Sarin (Agent GB, isopropyl methylphosphonofluoridate) is an organophosphate cholinesterase inhibitor. Sarin (Type I or Type II) was administered by gavage to CD rats on d 6-15 of gestation at dose levels of 0, 100, 240, or 380 mu g/kg/d and to New Zealand White (NZW) rabbits on d 6-19 of gestation at dose levels of 0, 5, 10, or 15 mu g/kg/d. Females were weighed on gestational days (GD) 0, 6-16 for rats and 6-20 for rabbits, and immediately prior to termination (GD 20 for rats and GD 29 for rabbits). All animals were monitored daily for clinical signs of toxicity throughout dosing and until sacrifice. At necropsy, gravid uteri were weighed and examined for the number and status of implants (live, resorbed, or dead). Individual fetal body weight, malformations, and variations (external, visceral, and skeletal) were recorded. Rat and rabbit dams in the high-dose groups exhibited significant signs of maternal toxicity and increased maternal mortality. Examination of gravid uteri revealed no statistical differences among treatment groups in the incidence of resorptions or of dead or malformed fetuses, or in average body weight of live fetuses per litter. These results show no evidence of developmental toxicity in the CD rat or NZW rabbit following exposure to either Type I or Type II sarin during embryonic differentiation and major organogenesis, even at a dose that produced maternal toxicity. C1 NATL CTR TOXICOL RES,DIV REPROD & DEV TOXICOL,JEFFERSON,AR 72079. PATHOL ASSOCIATES INC,JEFFERSON,AR. USA,BIOMED RES & DEV LAB,FT DETRICK,MD. NR 14 TC 8 Z9 8 U1 0 U2 0 PU TAYLOR & FRANCIS PI BRISTOL PA 1900 FROST ROAD, SUITE 101, BRISTOL, PA 19007-1598 SN 0098-4108 J9 J TOXICOL ENV HEALTH JI J. Toxicol. Environ. Health PD FEB 23 PY 1996 VL 47 IS 3 BP 249 EP 265 DI 10.1080/009841096161771 PG 17 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA TW555 UT WOS:A1996TW55500004 PM 8604149 ER PT J AU Vlahacos, CP Jensen, JO AF Vlahacos, CP Jensen, JO TI Structure of percubylcubane. Relationship to supercubane, S-6 and O symmetries and chiral aspects SO THEOCHEM-JOURNAL OF MOLECULAR STRUCTURE LA English DT Article DE cubane; cubylcubane; percubylcubane; supercubane; superdense carbon ID ELECTRONIC-PROPERTIES; MOLECULAR-STRUCTURE; SOLID-STATE; BOND LENGTH; CARBON; ABINITIO; CUBANE; PRESSURE; DIAMOND; FILMS AB We report the computed equilibrium geometry of percubylcubane which serves as a model for supercubane. Supercubane is a very dense form of carbon thought to be composed of cubane subunits. Results for cubane, cubylcubane and percubylcubane are presented. Calculations were carried out for cubane and cubylcubane with Hartree-Fock and MP2 wavefunctions using the STO-3G and 6-31G* basis sets, respectively. A calculation was carried out for percubylcubane with a Hartree-Fock wavefunction and the STO-3G basis set. A comparison of the calculated geometries of cubane and cubylcubane with the corresponding experimental data yields correction factors for the equilibrium geometry computed for percubylcubane. Percubylcubane was determined to have a structure with 0 symmetry. The dihedral angles for the intercube bonds are rotated approximately 15 degrees from the previously postulated Burdett and Lee structure. The 15 degrees rotation occurs primarily for steric reasons. This rotation may also explain why supercubane is more dense than would be expected from the Burdett and Lee structure. Using our structure for percubylcubane as a non-primitive unit cell, we propose an alternative structure for supercubane. The primitive unit cell of our proposed structure is of Sg symmetry and the crystal group is (C-3i(2), No. 148). C1 SCI & TECHNOL CORP,HAMPTON,VA 23666. USA,EDGEWOOD RES,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. NR 61 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-1280 J9 THEOCHEM-J MOL STRUC JI Theochem-J. Mol. Struct. PD FEB 23 PY 1996 VL 362 IS 2 BP 225 EP 234 PG 10 WC Chemistry, Physical SC Chemistry GA TX911 UT WOS:A1996TX91100009 ER PT J AU Bose, D Candler, GV AF Bose, D Candler, GV TI Thermal rate constants of the N-2+O->NO+N reaction using ab initio (3)A'' and (3)A' potential energy surfaces SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID ATMOSPHERIC REACTION; TRAJECTORY CALCULATIONS; DYNAMICS AB Theoretical determinations of the thermal rate constants and product energy distributions of the N-2+O-->NO+N reaction, which plays a crucial role in hydrocarbon air combustion and high temperature air chemistry, are carried out using a quasiclassical trajectory method. An analytical fit of the lowest (3)A' potential energy surface of this reaction based on the CCI ab initio data is obtained. The trajectory study is done on this surface and an analytical 3A '' surface proposed by Gilibert et al. [J. Chem. Phys. 97, 5542 (1992)]. The thermal rate constants computed from 3000 to 20 000 K are in good agreement with the available experimental data. In addition, the dependence of the rate constant on the N-2 internal state is studied. It is found that a low vibrational excitation can reduce the rate constant of this reaction by a factor of 3. Also, we investigate the effect of the N-2 vibrational state on the product NO vibrational distribution, and it is found that at low Nz vibrational states, the NO vibrational distribution is nearly Boltzmann. However, at N-2(v>10), the product distribution is almost uniform at low energy levels. (C) 1996 American Institute of Physics. RP Bose, D (reprint author), UNIV MINNESOTA, DEPT AEROSP ENGN & MECH, ARMY HIGH PERFORMANCE COMP RES CTR, 110 UNION ST SE, MINNEAPOLIS, MN 55455 USA. NR 35 TC 82 Z9 83 U1 0 U2 4 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD FEB 22 PY 1996 VL 104 IS 8 BP 2825 EP 2833 DI 10.1063/1.471106 PG 9 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA TV787 UT WOS:A1996TV78700010 ER PT J AU Karl, M Saviolakis, GA Gravanis, A Chrousos, GP Margioris, AN AF Karl, M Saviolakis, GA Gravanis, A Chrousos, GP Margioris, AN TI The PC12 rat pheochromocytoma cell line expresses the prodynorphin gene and secretes the 8 kDa dynorphin product SO REGULATORY PEPTIDES LA English DT Article DE PC12; pheochromocytoma; dynorphin; opioid ID PHENYLETHANOLAMINE N-METHYLTRANSFERASE; BOVINE ADRENAL-MEDULLA; INSITU HYBRIDIZATION; CHROMAFFIN CELLS; PROENKEPHALIN-A; OPIOID-PEPTIDES; MESSENGER-RNAS; OPIATE BINDING; PITUITARY; ENKEPHALINS AB Most adrenal chromaffin cells synthesize opioids derived from proenkephalin but not from prodynorphin. However, human pheochromocytomas and the PC12 rat pheochromocytoma cell line synthesize dynorphins. The aim of this study was to confirm the presence of the authentic prodynorphin transcript and its dynorphin product in PC12 cells. We have found that the sequence of a 458 bp cDNA fragment derived from RT-PCR amplification of total PC12 RNA was in complete accordance with the published sequence of the equivalent region of the prodynorphin gene. It encodes the potent endogenous kappa opioid agonists alpha-neo-endorphin, dynorphin A and dynorphin B. Furthermore, immunoaffinity-purified PC12 cell extracts were subjected to RP-HPLC. Most of its IR-dynorphin eluted on a peak exhibiting the retention time of similarly treated rat anterior pituitary. The expression of the prodynorphin gene in pheochromocytomas can be explained as either the result of (a) the process of dedifferentiation of chromaffin cells to pheochromocytoma which may thus cause the expression of a previously unexpressed prodynorphin or that (b) those pheochromocytomas expressing the prodynorphin gene derive from the few, centrally located chromaffin cells, which express this gene even under normal conditions. C1 NICHHD, NIH, DEV ENDOCRINOL BRANCH, BETHESDA, MD 20892 USA. WALTER REED ARMY INST RES, DEPT MED NEUROSCI, WASHINGTON, DC 20307 USA. UNIV CRETE, SCH MED, DEPT PHARMACOL, GR-71110 IRAKLION, GREECE. UNIV CRETE, SCH MED, DEPT CLIN CHEM, GR-71110 IRAKLION, GREECE. NR 37 TC 7 Z9 7 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-0115 J9 REGUL PEPTIDES JI Regul. Pept. PD FEB 22 PY 1996 VL 61 IS 2 BP 99 EP 104 DI 10.1016/0167-0115(95)00144-1 PG 6 WC Endocrinology & Metabolism; Physiology SC Endocrinology & Metabolism; Physiology GA TY798 UT WOS:A1996TY79800003 PM 8852811 ER PT J AU Hoge, CW Shlim, DR Echeverria, P Rajah, R Herrmann, JE Cross, JH AF Hoge, CW Shlim, DR Echeverria, P Rajah, R Herrmann, JE Cross, JH TI Epidemiology of diarrhea among expatriate residents living in a highly endemic environment SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID ENTEROPATHOGENIC ESCHERICHIA-COLI; TRAVELERS DIARRHEA; MONOCLONAL-ANTIBODIES; CAMPYLOBACTER-JEJUNI; FOREIGN RESIDENTS; ANTIGEN-DETECTION; UNITED-STATES; MEXICO; CELLS; GASTROENTERITIS AB Objective.-To determine the etiology of diarrhea among expatriate residents living in a developing country and identify risk factors for travelers' diarrhea that are difficult to evaluate in tourist populations. Design.-Clinic-based case-control study. Setting.-Primary care travel medicine clinic in Kathmandu, Nepal. Participants.-A total of 69 expatriate residents with diarrhea, compared with 120 tourists with diarrhea, and 112 asymptomatic resident and tourist controls, selected systematically during a 1-year period. Main Outcome Measures.-Risk factors for diarrhea assessed by questionnaire and pathogen prevalence assessed by microbiologic analysis of stool specimens. Results.-The dominant risk factors for diarrhea among expatriate residents included younger age (P=.003), shorter duration of stay in Nepal (P<.001), and eating out in restaurants ((=.01). Eating raw vegetables, salads, fresh fruit, or ice served in restaurants was not significantly associated with diarrhea. Longer duration of residence was linearly correlated with protection. Enteric pathogens were identified in 44 (64%) of 69 residents with diarrhea compared with 100 (83%) of 120 tourists with diarrhea, with enterotoxigenic Escherichia coli, Campylobacter, and Shigella predominant for both groups. Pathogens were also found in stools;from 32 (37%) of 87 asymptomatic resident controls and 13 (52%) of 25 tourist controls. The attack rate of diarrhea among expatriates was estimated to be 49% (95% confidence interval, 37% to 61%) per month during the first 2 years of residence. The highest-risk months were April through July. Conclusions.-Diarrhea among expatriates in a highly endemic environment is a persistent risk. The extremely high prevalence of enteric pathogens among asymptomatic persons reflects widespread exposure. The most important risk factors for travelers' diarrhea are difficult to modify, including younger age, duration of stay, eating in restaurants, and seasonality. Preventive dietary recommendations may not be fully protective, suggesting that pretravel advice should emphasize empiric treatment in addition to strategies to avoid exposure. C1 ARMED FORCES RES INST MED SCI,DEPT BACTERIOL IMMUNOL & MOLEC GENET,BANGKOK 10400,THAILAND. CIWEC CLIN,KATMANDU,NEPAL. UNIV MASSACHUSETTS,MED CTR,DIV INFECT DIS,WORCESTER,MA. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 33 TC 66 Z9 66 U1 0 U2 4 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD FEB 21 PY 1996 VL 275 IS 7 BP 533 EP 538 DI 10.1001/jama.275.7.533 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA TV569 UT WOS:A1996TV56900030 PM 8606474 ER PT J AU DAprano, A Salomon, M Iammarino, M AF DAprano, A Salomon, M Iammarino, M TI Conductance of alkali metal perchlorates in propylene carbonate at 25 degrees C SO JOURNAL OF ELECTROANALYTICAL CHEMISTRY LA English DT Article DE stokes hydrodynamic radii; conductance; alkali metal perchlorates; propylene carbonate ID 1-1 ELECTROLYTES; ASSOCIATION; VISCOSITY; WATER C1 USA,ARL,CHEM BIOL SCI DIV,FT MONMOUTH,NJ 07703. RP DAprano, A (reprint author), UNIV ROMA LA SAPIENZA,DEPT CHEM,P LE A MORO 5,I-00185 ROME,ITALY. NR 43 TC 6 Z9 6 U1 0 U2 3 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0022-0728 J9 J ELECTROANAL CHEM JI J. Electroanal. Chem. PD FEB 21 PY 1996 VL 403 IS 1-2 BP 245 EP 249 DI 10.1016/0022-0728(95)04310-1 PG 5 WC Chemistry, Analytical; Electrochemistry SC Chemistry; Electrochemistry GA UC619 UT WOS:A1996UC61900029 ER PT J AU Payne, BS Miller, AC AF Payne, BS Miller, AC TI Life history and production of filter-feeding insects on stone dikes in the lower Mississippi River SO HYDROBIOLOGIA LA English DT Article DE production; life history; Hydropsyche orris; Rheotanytarsus sp; lower Mississippi River ID NET-SPINNING CADDISFLIES; SOUTHERN APPALACHIAN STREAM; SECONDARY PRODUCTION; CHIRONOMIDAE DIPTERA; BLACKWATER RIVER; TRICHOPTERA; HYDROPSYCHIDAE; MINNESOTA; PATTERNS; CYCLES AB Population and production dynamics of two filter-feeding macroinvertebrates, the caddisfly Hydropsyche ol-ris and the midge Rheotanytarsus sp., were examined in the lower Mississippi River Miles 510-515. Samples were collected from September to November 1987, May to December 1988, and March to May 1989 from stone dikes that protrude into the river. Developmental synchrony was high among individuals in both populations, and seasonal changes in the relative abundance of instars indicated bivoltine and trivoltine life cycles for H. orris and Rheotanytarsus sp., respectively. The size frequency method was used to estimate production (P) and biomass (B) of each cohort in each population. P/B ratios for spring and fall cohorts of H. orris equaled 4.5 and 3.7. Spring, summer, and fall cohorts of Rheotanytarsus sp. had P/B ratios of 4.0, 4.7, and 4.1, respectively. Annual production, estimated as the sum of cohort production values, of the H. orris and Rheotanytarsus sp, population equaled 10.1 and 0.359 g m(-2) (dry weight). Annual P/B ratios equaled 10.8 and 16.1 for the H. orris and Rheotanytarsus sp. populations, closely matching values expected for bivoltine and trivoltine populations, respectively. Annual production of H. orris is in the low end of the range of published estimates for other lotic hydropsychid populations inhabiting coarse substratum in warm, lowland rivers of medium size or small, trophically enriched streams. Annual production of Rheotanytarsus sp. is the first such estimate based on a simultaneous assessment of life cycle and production. Given the lack of naturally occurring gravel and cobble substrate in the lower Mississippi River, stone dikes are an especially important habitat for N. orris and Rheotanytarsus sp. RP Payne, BS (reprint author), USA,ENGINEER WATERWAYS EXPT STN,ENVIRONM LAB,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 31 TC 6 Z9 6 U1 0 U2 7 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0018-8158 J9 HYDROBIOLOGIA JI Hydrobiologia PD FEB 16 PY 1996 VL 319 IS 2 BP 93 EP 102 DI 10.1007/BF00016877 PG 10 WC Marine & Freshwater Biology SC Marine & Freshwater Biology GA UE147 UT WOS:A1996UE14700002 ER PT J AU Vendier, O Jokerst, NM Leavitt, RP AF Vendier, O Jokerst, NM Leavitt, RP TI High efficiency thin-film GaAs-based MSM photodetectors SO ELECTRONICS LETTERS LA English DT Article DE metal-semiconductor-metal structures; photodetectors AB To increase the sensitivity of high speed GaAs based metal-semiconductor-metal (MSM) photodetectors, thin film inverted MSMs (fingers on the bottom) have been fabricated and compared to bulk MSMs. The inverted MSMs exhibit a record 95% external quantum efficiency, a bandwidth of 5.9 GHz, and <5 nA dark current at 10 V bias. C1 AMSRL EP EE,ARMY RES LABS,ADELPHI,MD 20783. INST NATL SCI APPL,CNRS URA 74,F-31077 TOULOUSE,FRANCE. RP Vendier, O (reprint author), GEORGIA INST TECHNOL,MFG RES CTR,CTR MICROELECTR RES,SCH ELECT & COMP ENGN,ATLANTA,GA 30332, USA. NR 5 TC 10 Z9 10 U1 0 U2 1 PU IEE-INST ELEC ENG PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD, ENGLAND SG1 2AY SN 0013-5194 J9 ELECTRON LETT JI Electron. Lett. PD FEB 15 PY 1996 VL 32 IS 4 BP 394 EP 395 DI 10.1049/el:19960231 PG 2 WC Engineering, Electrical & Electronic SC Engineering GA UL770 UT WOS:A1996UL77000080 ER PT J AU Rohaly, AM Rubin, GS AF Rohaly, AM Rubin, GS TI The effects of spatial phase quantization on peripheral face recognition SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 USA,RES LAB,ABERDEEN PROVING GROUND,MD. JOHNS HOPKINS UNIV,LIONS VIS CTR,BALTIMORE,MD. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD FEB 15 PY 1996 VL 37 IS 3 BP 908 EP 908 PG 1 WC Ophthalmology SC Ophthalmology GA TX397 UT WOS:A1996TX39700906 ER PT J AU Casey, P Kelly, P Giovannini, J Dunlap, W Bauman, W AF Casey, P Kelly, P Giovannini, J Dunlap, W Bauman, W TI Outcome measures in diabetic retinopathy screening SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 WILFORD HALL USAF MED CTR,DEPT OPHTHALMOL,LACKLAND AFB,TX. BROOKE ARMY MED CTR,DEPT OPHTHALMOL,FT SAM HOUSTON,TX. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD FEB 15 PY 1996 VL 37 IS 3 BP 992 EP 992 PG 1 WC Ophthalmology SC Ophthalmology GA TX397 UT WOS:A1996TX39700990 ER PT J AU Nagineni, CN Pardhasaradhi, K Martins, MC Detrick, B Hooks, JJ AF Nagineni, CN Pardhasaradhi, K Martins, MC Detrick, B Hooks, JJ TI Mechanisms of interferon induced inhibition of Toxoplasma gondii replication in human RPE cells SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 NEI,NIH,BETHESDA,MD 20892. WALTER REED ARMY INST RES,WASHINGTON,DC. GEORGE WASHINGTON UNIV,MED CTR,WASHINGTON,DC 20037. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD FEB 15 PY 1996 VL 37 IS 3 BP 1729 EP 1729 PG 1 WC Ophthalmology SC Ophthalmology GA TX397 UT WOS:A1996TX39701727 ER PT J AU Belyea, DA Dan, JA Lieberman, MF Stamper, RL Spencer, WH AF Belyea, DA Dan, JA Lieberman, MF Stamper, RL Spencer, WH TI Late onset of sequential multifocal bleb leaks after filtration surgery with antimetabolites (5-fluorouracil and mitomycin C) SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. CALIF PACIFIC MED CTR,SAN FRANCISCO,CA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD FEB 15 PY 1996 VL 37 IS 3 BP 1901 EP 1901 PG 1 WC Ophthalmology SC Ophthalmology GA TX397 UT WOS:A1996TX39701899 ER PT J AU Doe, EA OHara, M Jones, P Brown, S AF Doe, EA OHara, M Jones, P Brown, S TI A comparison of prophylactic ondansetron and droperidol for strabismus repair in adults. SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,DEPT OPHTHALMOL,SAN ANTONIO,TX. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD FEB 15 PY 1996 VL 37 IS 3 BP 2229 EP 2229 PG 1 WC Ophthalmology SC Ophthalmology GA TX397 UT WOS:A1996TX39702227 ER PT J AU Specht, CS Varga, JH Tellado, MV Roth, JA AF Specht, CS Varga, JH Tellado, MV Roth, JA TI Retinal dysplasia, megalencephaly, and neurocutaneous vascular telangiectasia - Relationship to phakomatosis hamartoma syndromes SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 SHADYSIDE HOSP,PITTSBURGH,PA 15232. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. OVERLOOK HOSP,SUMMIT,NJ. ARMED FORCES INST PATHOL,WASHINGTON,DC 20306. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD FEB 15 PY 1996 VL 37 IS 3 BP 2265 EP 2265 PG 1 WC Ophthalmology SC Ophthalmology GA TX397 UT WOS:A1996TX39702263 ER PT J AU CuQlockKnopp, VG Sipes, DE Torgerson, WT Bender, EJ Merritt, JO AF CuQlockKnopp, VG Sipes, DE Torgerson, WT Bender, EJ Merritt, JO TI Field of view versus resolution trade-off for night vision goggle simulators SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 USA,RES LAB,HUMAN RES & ENGN DIRECTORATE,WASHINGTON,DC. JOHNS HOPKINS UNIV,BALTIMORE,MD 21218. USA,COMMUN ELECTR COMMAND,NIGHT VIS & ELECTR SENSORS DIRECTORATE,WASHINGTON,DC. INTERACT TECHNOL,WILLIAMSBURG,MA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD FEB 15 PY 1996 VL 37 IS 3 BP 2367 EP 2367 PG 1 WC Ophthalmology SC Ophthalmology GA TX397 UT WOS:A1996TX39702368 ER PT J AU Rabin, J Wiley, R AF Rabin, J Wiley, R TI A psychophysical comparison between dynamic visual performance of CRTs and LCDs SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 USA,AEROMED RES LAB,FT RUCKER,AL 36362. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD FEB 15 PY 1996 VL 37 IS 3 BP 2384 EP 2384 PG 1 WC Ophthalmology SC Ophthalmology GA TX397 UT WOS:A1996TX39702385 ER PT J AU Karesh, JW Amrein, B Keel, FM Epley, KD AF Karesh, JW Amrein, B Keel, FM Epley, KD TI Evaluation of compressed air trauma to the human eye in an eye bank model SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 SINAI HOSP,KRIEGER EYE INST,BALTIMORE,MD 21215. USA,RES LAB,ABERDEEN,MD. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD FEB 15 PY 1996 VL 37 IS 3 BP 2863 EP 2863 PG 1 WC Ophthalmology SC Ophthalmology GA TX397 UT WOS:A1996TX39702859 ER PT J AU Denny, JB Moore, RE Schuschereba, ST AF Denny, JB Moore, RE Schuschereba, ST TI Similar levels of GAP-43 are present in the inner plexiform layer of laser-irradiated and control areas of adult rabbit retina SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 UNIV TEXAS,DIV LIFE SCI,SAN ANTONIO,TX 78285. USA,MED RES DETACHMENT,WALTER REED ARMY INST RES,DEPT CELL & MOLEC BIOL,SAN ANTONIO,TX. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD FEB 15 PY 1996 VL 37 IS 3 BP 2954 EP 2954 PG 1 WC Ophthalmology SC Ophthalmology GA TX397 UT WOS:A1996TX39702950 ER PT J AU Schuschereba, ST Cross, ME Pizarro, JM Ujimori, V Nemeth, TJ Bowman, PD Stuck, BE Marshall, J AF Schuschereba, ST Cross, ME Pizarro, JM Ujimori, V Nemeth, TJ Bowman, PD Stuck, BE Marshall, J TI Pretreatment with hydroxyethyl starch-deferoxamine but not glucocorticoids limits neutrophil infiltration in acute retinal laser injury SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 USA,MED RES DETACHMENT,WALTER REED ARMY INST RES,BROOKS AFB,TX 78235. USA,INST SURG RES,FT SAM HOUSTON,TX 78234. UNIV LONDON,UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,LONDON,ENGLAND. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD FEB 15 PY 1996 VL 37 IS 3 BP 3174 EP 3174 PG 1 WC Ophthalmology SC Ophthalmology GA TX397 UT WOS:A1996TX39703170 ER PT J AU Alfaro, DV Kasowski, EJ Barton, CP Hudson, SJ Brucker, AJ Bauman, WC AF Alfaro, DV Kasowski, EJ Barton, CP Hudson, SJ Brucker, AJ Bauman, WC TI Experimental posttraumatic Pseudomonas endophthalmitis in a swine model: Treatment with ceftazidime, amikacin, and imipenem SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 UNIFORMED SERV UNIV HLTH SCI, BETHESDA, MD 20814 USA. NATL NAVAL MED CTR, BETHESDA, MD USA. BROOKE ARMY MED CTR, SAN ANTONIO, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD FEB 15 PY 1996 VL 37 IS 3 BP 3198 EP 3198 PG 1 WC Ophthalmology SC Ophthalmology GA TX397 UT WOS:A1996TX39703194 ER PT J AU Haverly, RF Glickman, RD Harrison, JM Zwick, H Longbotham, HG Pierce, B AF Haverly, RF Glickman, RD Harrison, JM Zwick, H Longbotham, HG Pierce, B TI Sweep-VEP measurement of contrast sensitivity in patients with either retinitis pigmentosa or macular disease SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 UNIV TEXAS,HLTH SCI CTR,DEPT OPHTHALMOL,SAN ANTONIO,TX. USA,MED RES DETACHMENT,WALTER REED ARMY INST RES,BROOKS AFB,TX. CONCEPTUAL MIND WORKS INC,SAN ANTONIO,TX. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD FEB 15 PY 1996 VL 37 IS 3 BP 3234 EP 3234 PG 1 WC Ophthalmology SC Ophthalmology GA TX397 UT WOS:A1996TX39703230 ER PT J AU Hadley, SC Mader, TH Shannon, SG Mason, KT AF Hadley, SC Mader, TH Shannon, SG Mason, KT TI Early cataract extraction for military aviators: The US Army Aviation Epidemiology Data Register SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 MADIGAN ARMY MED CTR,DEPT OPHTHALMOL,TACOMA,WA 98431. USA,AEROMED RES LAB,FT RUCKER,AL. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD FEB 15 PY 1996 VL 37 IS 3 BP 3484 EP 3484 PG 1 WC Ophthalmology SC Ophthalmology GA TX397 UT WOS:A1996TX39703479 ER PT J AU Lund, DJ Edsall, PR Fuller, DR Hoxie, SW AF Lund, DJ Edsall, PR Fuller, DR Hoxie, SW TI Ocular hazards of tunable continuous-wave near-infrared laser sources SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 USA,MED RES DETACHMENT,WALTER REED ARMY INST RES,SAN ANTONIO,TX. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD FEB 15 PY 1996 VL 37 IS 3 BP 3580 EP 3580 PG 1 WC Ophthalmology SC Ophthalmology GA TX397 UT WOS:A1996TX39703574 ER PT J AU Zuclich, JA Zwick, H Belkin, M Schuschereba, ST AF Zuclich, JA Zwick, H Belkin, M Schuschereba, ST TI Laser-induced retinal nerve fiber layer injury in the nonhuman primate retina SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 USA,MED RES DETACHMENT,SAN ANTONIO,TX. NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD FEB 15 PY 1996 VL 37 IS 3 BP 3581 EP 3581 PG 1 WC Ophthalmology SC Ophthalmology GA TX397 UT WOS:A1996TX39703575 ER PT J AU Stuck, BE Zwick, H Gagliano, DA Molchany, JW Lund, DJ AF Stuck, BE Zwick, H Gagliano, DA Molchany, JW Lund, DJ TI Human eye injuries induced by accidental Q-switched laser exposures SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 USA,MED RES DETACHMENT,WALTER REED ARMY INST RES,SAN ANTONIO,TX. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD FEB 15 PY 1996 VL 37 IS 3 BP 3582 EP 3582 PG 1 WC Ophthalmology SC Ophthalmology GA TX397 UT WOS:A1996TX39703576 ER PT J AU Ness, J Zwick, H Stuck, BE Molchany, JW AF Ness, J Zwick, H Stuck, BE Molchany, JW TI Comparison of artificial and accidental laser induced macula scotoma on contrast sensitivity SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 USA,MED RES DETACHMENT,SAN ANTONIO,TX. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD FEB 15 PY 1996 VL 37 IS 3 BP 3583 EP 3583 PG 1 WC Ophthalmology SC Ophthalmology GA TX397 UT WOS:A1996TX39703577 ER PT J AU Peele, KA Belyea, DA Kennerdell, JS Maroon, JC AF Peele, KA Belyea, DA Kennerdell, JS Maroon, JC TI Asymmetric intraocular pressure in sphenoid wing meningioma patients SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 ALLEGHENY GEN HOSP,DEPT OPHTHALMOL,PITTSBURGH,PA 15212. ALLEGHENY GEN HOSP,DEPT NEUROSURG,PITTSBURGH,PA 15212. WALTER REED ARMY MED CTR,OPHTHALMOL SERV,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD FEB 15 PY 1996 VL 37 IS 3 BP 3750 EP 3750 PG 1 WC Ophthalmology SC Ophthalmology GA TX397 UT WOS:A1996TX39703744 ER PT J AU Sepanski, GJ Campagna, JA AF Sepanski, GJ Campagna, JA TI The medical management of glaucoma: A cost analysis SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,OPHTHALMOL SERV,FT SAM HOUSTON,TX. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD FEB 15 PY 1996 VL 37 IS 3 BP 3821 EP 3821 PG 1 WC Ophthalmology SC Ophthalmology GA TX397 UT WOS:A1996TX39703815 ER PT J AU Merkle, LD Zandi, B Moncorge, R Guyot, Y Verdun, HR McIntosh, B AF Merkle, LD Zandi, B Moncorge, R Guyot, Y Verdun, HR McIntosh, B TI Spectroscopy and laser operation of Pr, Mg:SrAl12O19 SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID STIMULATED-EMISSION; ROOM-TEMPERATURE; CRYSTALS AB Pr3+-doped SrAl12O19 has been investigated spectroscopically as a visible laser material. Its P-3(0) fluorescence lifetime is rather long for an oxide, about 35 mu s. This excited state exhibits only mild concentration and temperature quenching, so that concentrations high enough to give good ground state absorption into the P-3(0) and P-3(1) manifolds still give strong, long-lived emission. The ground state absorption spectra indicate that excited state absorption into the 4f5d configuration is less likely to be significant at laser wavelengths in this host than in Y3Al5O12. The stimulated emission cross sections of major emission lines have been estimated, and are quite realistic for laser operation. Laser pumped laser operation has been demonstrated in the red (P-3(0)-->F-3(2)) at room temperature and in the blue-green (P-3(0)-->H-3(4)) at cryogenic temperatures. (C) 1996 American Institute of Physics. C1 UNIV LYON 1,CNRS,UA 442,LAB PHYSICOCHIM MAT LUMINESCENTS,F-69622 VILLEURBANNE,FRANCE. FIBERTEK INC,HERNDON,VA 22070. RP Merkle, LD (reprint author), USA,RES LAB,INFRARED OPT TECHNOL OFF,10235 BURBECK RD,SUITE 110,FT BELVOIR,VA 22060, USA. RI Guyot, Yannick/B-5847-2014 NR 25 TC 55 Z9 56 U1 2 U2 16 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD FEB 15 PY 1996 VL 79 IS 4 BP 1849 EP 1856 DI 10.1063/1.361085 PG 8 WC Physics, Applied SC Physics GA TV540 UT WOS:A1996TV54000002 ER PT J AU Barth, J AF Barth, J TI Derivatives: A comprehensive resource for options, futures, interest rate swaps, and mortgage securities - Arditti,FD SO LIBRARY JOURNAL LA English DT Book Review RP Barth, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD FEB 15 PY 1996 VL 121 IS 3 BP 158 EP 158 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA TV123 UT WOS:A1996TV12300098 ER PT J AU OBrien, WA Hartigan, PM Martin, D Esinhart, J Hill, A Benoit, S Rubin, M Lahart, C Wray, N Finegold, SM George, WL Dickinson, GM Klimas, N Diamond, G ZollaPazner, SB Jensen, PC Hawkes, C Oster, C Gordin, F Labriola, AM Spivey, P Matthews, T Weinhold, K Drusano, G Egorin, MJ AF OBrien, WA Hartigan, PM Martin, D Esinhart, J Hill, A Benoit, S Rubin, M Lahart, C Wray, N Finegold, SM George, WL Dickinson, GM Klimas, N Diamond, G ZollaPazner, SB Jensen, PC Hawkes, C Oster, C Gordin, F Labriola, AM Spivey, P Matthews, T Weinhold, K Drusano, G Egorin, MJ TI Changes in plasma HIV-1 RNA and CD4+ lymphocyte counts and the risk of progression to AIDS SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID IMMUNODEFICIENCY-VIRUS-INFECTION; CONTROLLED TRIAL; CLINICAL-TRIALS; END-POINTS; REVERSE-TRANSCRIPTASE; P24 ANTIGEN; ZIDOVUDINE; MARKER; NEOPTERIN; RESISTANCE AB Background. Clinical trials of antiretroviral drugs can take years to complete because the outcomes measured are progression to the acquired immunodeficiency syndrome (AIDS) or death. Trials could be accelerated by the use of end points such as changes in CD4+ lymphocyte counts and plasma levels of human immunodeficiency virus type 1 (HIV-1) RNA and beta(2)-microglobulin, but there is uncertainty about whether these surrogate measures are valid predictors of disease progression. Methods. We analyzed data from the Veterans Affairs Cooperative Study on AIDS, which compared immediate with deferred zidovudine therapy. Patients' plasma levels of HIV-1 RNA and beta(2)-microglobulin were measured in stored plasma. Results. Among the 129 patients in the immediate-treatment group, 34 had disease that progressed to AIDS, as compared with 57 of the 141 patients in the deferred-treatment group (P=0.03). Progression to AIDS correlated strongly with base-line CD4+ lymphocyte counts (P=0.001) and plasma levels of HIV-1 RNA (P<0.001), but not with base-line levels of beta(2)-microglobulin (P=0.14). A decrease of at least 75 percent in the plasma level of HIV-1 RNA over the first six months of zidovudine therapy accounted for 59 percent of the benefit of treatment, defined as the absence of progression to AIDS (95 percent confidence interval, 13 to 112 percent). Plasma beta(2)-microglobulin levels and CD4+ lymphocyte counts explained less of the effect of treatment. A 75 percent decrease in the plasma HIV-1 RNA level plus a 10 percent increase in the CD4+ lymphocyte count could explain 79 percent of the treatment effect (95 percent confidence interval, 27 to 145 percent). Conclusions. Treatment-induced changes in the plasma HIV-1 RNA level and the CD4+ lymphocyte count, taken together, are valid predictors of the clinical progression of HIV-related disease and can be used to assess the efficacy of zidovudine and possibly other antiretroviral drugs as well. (C) 1996, Massachusetts Medical Society. C1 UNIV CALIF LOS ANGELES,SCH MED,LOS ANGELES,CA. VET AFFAIRS COOPERAT STUDIES PROGRAM,COORDINATING CTR,W HAVEN,CT. UNIV N CAROLINA,CHAPEL HILL,NC. GLAXO INC,RES TRIANGLE PK,NC 27709. VET AFFAIRS MED CTR,NEW YORK,NY. NYU,SCH MED,NEW YORK,NY. DUKE UNIV,MED CTR,DURHAM,NC. VET AFFAIRS MED CTR,DURHAM,NC 27705. VET AFFAIRS MED CTR,HOUSTON,TX 77030. VET ADM MED CTR,MIAMI,FL 33125. VET ADM MED CTR,SAN FRANCISCO,CA 94121. WALTER REED ARMY MED CTR,WASHINGTON,DC. VET ADM MED CTR,WASHINGTON,DC 20422. DUKE UNIV,VIROL CTR,DURHAM,NC 27706. UNIV MARYLAND,PHARMACOL LAB,COLLEGE PK,MD 20742. RP OBrien, WA (reprint author), W LOS ANGELES VET AFFAIRS MED CTR,DEPT MED,11301 WILSHIRE BLVD,LOS ANGELES,CA 90073, USA. NR 40 TC 604 Z9 609 U1 2 U2 12 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD FEB 15 PY 1996 VL 334 IS 7 BP 426 EP 431 DI 10.1056/NEJM199602153340703 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA TU696 UT WOS:A1996TU69600003 PM 8552144 ER PT J AU Zhao, M Vorontsov, MA Ricklin, JC AF Zhao, M Vorontsov, MA Ricklin, JC TI Spatiotemporal dynamics of self-pumped phase conjugation in a photorefractive crystal: Multipattern storage using incremental recording SO OPTICS LETTERS LA English DT Article ID NETWORKS AB We investigate the spatiotemporal dynamics of self-pumped phase conjugation for superimposed incrementally recorded images. Experimental evidence of time delay in the appearance of phase-conjugation patterns was observed during both the recording and the readout phases. (C) 1996 Optical Society of America C1 USA,RES LAB,BATTLEFIELD ENVIRONM DIRECTORATE,WHITE SANDS MISSILE RANGE,NM 88002. MOSCOW MV LOMONOSOV STATE UNIV,CTR INT LASER,MOSCOW 199899,RUSSIA. RP Zhao, M (reprint author), NEW MEXICO STATE UNIV,LAS CRUCES,NM 88003, USA. NR 9 TC 3 Z9 3 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD FEB 15 PY 1996 VL 21 IS 4 BP 257 EP 259 DI 10.1364/OL.21.000257 PG 3 WC Optics SC Optics GA TV855 UT WOS:A1996TV85500009 PM 19865371 ER PT J AU VanVechten, D Porter, FS Wood, KS Gulian, AM AF VanVechten, D Porter, FS Wood, KS Gulian, AM TI Alternative non-equilibrium superconducting X-ray detectors SO NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT LA English DT Article; Proceedings Paper CT 6th International Workshop on Low Temperature Detectors (LTD6) CY AUG 28-SEP 01, 1995 CL BEATENBERG, SWITZERLAND SP Beer Brawand Fdn, Bern ID FILMS AB Non-equilibrium X-ray detectors based on isotropic superconductor absorbers offer the hope of energy resolution limited by the statistics of excitation production, i.e., delta E/E similar to(Delta/E)(1/2), where Delta is the superconducting gap energy. This can be numerically equal to that of the best bolometers at significantly higher operating temperatures. Superconducting Tunnel Junction Detectors (STJDs) count the X-ray event induced excitations (quasiparticles (QP)) as an excursion of the subgap tunnel current. While STJDs are presently the best studied QP readout scheme, they have made slow progress toward the limiting energy resolution. Some of the difficulties are enumerated herein and are inherent in tunnel junctions. One alternative is to measure the conductivity excursion of a superconducting film that follows photon absorption. This excursion obeys exactly the same equation as the effective quasiparticle tunneling conductivity in a Josephson junction. Hence the two schemes should produce the same readout waveforms when the same superconducting absorbers are used. Seven specific approaches to realizing the measurement are presented. All versions of the conductivity readout offer simpler sample fabrication than STJD. Any superconducting material may be used. In commercial applications, the obvious benefit in operating temperature of using the HTSC materials may more than compensate for the penalty in energy resolution. C1 ARMENIAN ACAD SCI,INST PHYS RES,ASHTARAK 378410,ARMENIA. USA,NAVAL RES LAB,WASHINGTON,DC 20375. RI Porter, Frederick/D-3501-2012 OI Porter, Frederick/0000-0002-6374-1119 NR 8 TC 4 Z9 4 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-9002 J9 NUCL INSTRUM METH A JI Nucl. Instrum. Methods Phys. Res. Sect. A-Accel. Spectrom. Dect. Assoc. Equip. PD FEB 11 PY 1996 VL 370 IS 1 BP 34 EP 37 DI 10.1016/0168-9002(95)01039-4 PG 4 WC Instruments & Instrumentation; Nuclear Science & Technology; Physics, Nuclear; Physics, Particles & Fields SC Instruments & Instrumentation; Nuclear Science & Technology; Physics GA UA324 UT WOS:A1996UA32400012 ER PT J AU Anderson, RJ Sharp, EJ Wood, GL Salamo, GJ AF Anderson, RJ Sharp, EJ Wood, GL Salamo, GJ TI Image transfer by mutually pumped phase conjugators SO APPLIED OPTICS LA English DT Article ID PHOTOREFRACTIVE OSCILLATOR; MIRROR; CONVERSION; BATIO3; CRYSTALS; MEDIA AB Cross talk is observed during the transient time of the photorefractive grating formation in a mutually pumped phase conjugator. We show that this feature can be used to transfer pictorial information from one location to another. The transfer is instantaneous and is demonstrated at a resolution of 6 lines/mm. (C) 1996 Optical Society of America C1 USA,RES LAB,FT BELVOIR,VA 22060. UNIV ARKANSAS,DEPT PHYS,FAYETTEVILLE,AR 72701. RP Anderson, RJ (reprint author), NATL SCI FDN,WASHINGTON,DC 20550, USA. NR 28 TC 8 Z9 8 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD FEB 10 PY 1996 VL 35 IS 5 BP 854 EP 859 DI 10.1364/AO.35.000854 PG 6 WC Optics SC Optics GA TW590 UT WOS:A1996TW59000015 PM 21069081 ER PT J AU Kozikowski, AP Ding, QJ Saxena, A Doctor, BP AF Kozikowski, AP Ding, QJ Saxena, A Doctor, BP TI Synthesis of (+/-)-10,10-dimethylhuperzine A - A huperzine analogue possessing a slower enzyme off-rate SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS LA English DT Article ID ALKALOIDS; TACRINE AB The synthesis of (+/-)-10,10-dimethylhuperzine A is reported together with its kinetic (k(on) and k(off)) and dissociation constants for the inhibition of fetal bovine serum acetylcholinesterase. While somewhat more potent than (+/-)-huperzine A, the dimethyl analogue shows a slower off-rate from AChE, a result that may be of potential therapeutic value. C1 WALTER REED ARMY INST RES,DIV BIOCHEM,WASHINGTON,DC 20307. RP Kozikowski, AP (reprint author), GEORGETOWN UNIV,MED CTR,INST COGNIT & COMPUTAT SCI,3970 RESERVOIR RD NW,WASHINGTON,DC 20007, USA. NR 21 TC 26 Z9 31 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0960-894X J9 BIOORG MED CHEM LETT JI Bioorg. Med. Chem. Lett. PD FEB 6 PY 1996 VL 6 IS 3 BP 259 EP 262 DI 10.1016/0960-894X(96)00012-1 PG 4 WC Chemistry, Medicinal; Chemistry, Organic SC Pharmacology & Pharmacy; Chemistry GA TV027 UT WOS:A1996TV02700009 ER PT J AU Clement, J Underwood, P Ward, D Pilaski, J LeDuc, J AF Clement, J Underwood, P Ward, D Pilaski, J LeDuc, J TI Hantavirus outbreak during military manoeuvres in Germany SO LANCET LA English DT Letter ID HEMORRHAGIC-FEVER; RENAL SYNDROME C1 EVANS US ARMY COMMUNITY HOSP,FT CARSON,CO. MED INST ENVIRONM HYG,DUSSELDORF,GERMANY. WHO,UNDP,DIV COMMUNICABLE DIS,MICROBIOL & IMMUNOL SUPPORT SERV,GENEVA 27,SWITZERLAND. RP Clement, J (reprint author), QUEEN ASTRID MIL HOSP,BELGIAN ZOONOSIS WORKGRP,B-1120 BRUSSELS,BELGIUM. NR 5 TC 38 Z9 39 U1 0 U2 1 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0140-6736 J9 LANCET JI Lancet PD FEB 3 PY 1996 VL 347 IS 8997 BP 336 EP 336 DI 10.1016/S0140-6736(96)90519-X PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA TT485 UT WOS:A1996TT48500067 PM 8569401 ER PT J AU George, SG Slack, WT Douglas, NH AF George, SG Slack, WT Douglas, NH TI Demography, habitat, reproduction, and sexual dimorphism of the crystal darter, Crystallaria asprella (Jordan), from south-central Arkansas SO COPEIA LA English DT Article ID STATISTICS; FISHES AB Habitat and demography of the crystal darter, Crystallaria asprella, from the Saline River, Arkansas, were studied utilizing field samples (March 1992 to Feb. 1993) and museum collections (1968-1991), Crystallaria were typically collected at depths of 114-148 cm and velocities of 46-90 cm/sec. Predominant substrata were gravel, small cobble, and patches of sand, Crystallaria were not collected from habitats containing mud, clay, or submerged aquatic vegetation, The reproductive season was from late Jan. through mid-April with a 1:1 sex ratio during the season, Clutch sizes were 106-576 mature oocytes/female and were positively correlated with SL (r(9) = 0.97, P < 0.01), Diameters of mature or ripening oocytes were 1.0-1.2 mm, Long-term changes in GSI and oocyte diameter were not apparent for the 25-year span represented by museum collections, Both sexes attained sexual maturity before Age I, when females were 50 mm and males 61 mm SL, Sexual dimorphism was pronounced immediately prior to and during the reproductive season, Mature males possessed longer soft dorsal and anal fins than females, Males were usually larger than females, although maximum sizes were not appreciably different, Life expectancy of Crystallaria was at least two years. C1 UNIV SO MISSISSIPPI,DEPT BIOL SCI,HATTIESBURG,MS 39406. NE LOUISIANA UNIV,DEPT BIOL,MONROE,LA 71209. RP George, SG (reprint author), WATERWAYS EXPT STN ERA,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 42 TC 6 Z9 8 U1 0 U2 2 PU AMER SOC ICHTHYOLOGISTS HERPETOLOGISTS BUSINESS OFFICE PI CARBONDALE PA SOUTHERN ILLINOIS UNIV, DEPT ZOOLOGY, CARBONDALE, IL 62901-6501 SN 0045-8511 J9 COPEIA JI Copeia PD FEB 2 PY 1996 IS 1 BP 68 EP 78 PG 11 WC Zoology SC Zoology GA TU870 UT WOS:A1996TU87000007 ER PT J AU Ways, M Kroenke, K Umali, J Buchwald, D AF Ways, M Kroenke, K Umali, J Buchwald, D TI Housestaff attitudes about work rounds SO ACADEMIC MEDICINE LA English DT Letter C1 UNIV WASHINGTON,DEPT MED,SEATTLE,WA. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 3 TC 5 Z9 5 U1 0 U2 1 PU HANLEY & BELFUS INC PI PHILADELPHIA PA 210 S 13TH ST, PHILADELPHIA, PA 19107 SN 1040-2446 J9 ACAD MED JI Acad. Med. PD FEB PY 1996 VL 71 IS 2 BP 108 EP 109 DI 10.1097/00001888-199602000-00005 PG 2 WC Education, Scientific Disciplines; Health Care Sciences & Services SC Education & Educational Research; Health Care Sciences & Services GA TU974 UT WOS:A1996TU97400006 PM 8615915 ER PT J AU Michael, NL Davis, KE LoomisPrice, LD VanCott, TC Burke, DS Redfield, RR Birx, DL AF Michael, NL Davis, KE LoomisPrice, LD VanCott, TC Burke, DS Redfield, RR Birx, DL TI V3 seroreactivity and sequence variation: Tracking the emergence of V3 genotypic variation in HIV-1-infected patients SO AIDS LA English DT Article DE HIV-1; antibodies; V3 loop; DNA sequencing; polymerase chain reaction; genetics ID IMMUNODEFICIENCY-VIRUS TYPE-1; PRINCIPAL NEUTRALIZING DETERMINANT; BLOOD MONONUCLEAR-CELLS; NUCLEOTIDE SUBSTITUTION; ANTIBODY-RESPONSE; OVERDOMINANT SELECTION; ENVELOPE GLYCOPROTEIN; PRIMARY INFECTION; MEMBRANE-FUSION; HIV-1 AB Objective: To investigate the relationship between V3-specific immune responses and viral quasispecies evolution in 10 HIV-1-seropositive patients enrolled in a phase I trial of recombinant gp160. Methods: Serologic responses to the HIVLAI V3 loop and autologous V3 loop DNA sequences were sequentially determined over a 3-4-year interval. Results: Six patients either seroconverted or had a greater than or equal to 42-fold boost in titer to the V3 reagent associated with an average of 3.2 amino-acid changes in their autologous V3 loops. Four patients with less than or equal to 11-fold change in titer to the V3 loop showed an average of 0.75 amino-acid changes. Attempts to measure autologous V3 loop responses in four patients using a peptide enzyme-linked immunosorbent assay technique did not show a distinct binding preference for autologous versus heterologous V3 loop peptides. Thus, we interpret seroreactivity to the heterologous HIVLAI V3 loop to reflect the broadness of the V3 immune response rather than a direct measure of epitope-specific Immune pressure. Conclusions: These data suggest that the broadness of serologic responses to viral epitopes are reflected in the rate of evolution of their cognate coding sequences and support the view that the immune response to HIV-1 results in the continuous selection of new viral variants during the course of disease. C1 WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD. HENRY M JACKSON FDN,ROCKVILLE,MD. WALTER REED ARMY MED CTR,DIV INFECT DIS,WASHINGTON,DC 20307. OI /0000-0002-5704-8094 NR 54 TC 7 Z9 7 U1 0 U2 0 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0269-9370 J9 AIDS JI Aids PD FEB PY 1996 VL 10 IS 2 BP 121 EP 129 DI 10.1097/00002030-199602000-00001 PG 9 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA TW205 UT WOS:A1996TW20500001 PM 8838699 ER PT J AU Ballato, A Stern, R AF Ballato, A Stern, R TI Innovative technology transfer initiatives SO AMERICAN CERAMIC SOCIETY BULLETIN LA English DT Article AB The Physical Sciences Directorate of the Army Research Laboratory has achieved significant success in the technology transfer/strategic alliance arena by blending technology transfer statutes, regulations and practices into its corporate culture. RP Ballato, A (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 1 TC 1 Z9 1 U1 0 U2 0 PU AMER CERAMIC SOC PI WESTERVILLE PA 735 CERAMIC PLACE, PO BOX 6136, WESTERVILLE, OH 43081-6136 SN 0002-7812 J9 AM CERAM SOC BULL JI Am. Ceram. Soc. Bull. PD FEB PY 1996 VL 75 IS 2 BP 73 EP 77 PG 5 WC Materials Science, Ceramics SC Materials Science GA TV291 UT WOS:A1996TV29100010 ER PT J AU Pinkard, NB Wilson, RW Lawless, N Dodd, LG McAdams, HP Koss, MN Travis, WD AF Pinkard, NB Wilson, RW Lawless, N Dodd, LG McAdams, HP Koss, MN Travis, WD TI Calcifying fibrous pseudotumor of pleura - A report of three cases of a newly described entity involving the pleura SO AMERICAN JOURNAL OF CLINICAL PATHOLOGY LA English DT Article DE pleura; pseudotumor; psammomatous calcification; fibrosis; calcification; hyalinization ID PULMONARY HYALINIZING GRANULOMA; LOWER RESPIRATORY-TRACT; PLASMA-CELL GRANULOMA; HISTIOCYTOMA; AMYLOIDOSIS; LESIONS; BENIGN; TUMOR; HEAD; NECK AB A newly recognized distinctive fibrous soft tissue lesion called ''calcifying fibrous pseudotumor'' (CFPT) was recently described in the soft tissues of the extremities, trunk, scrotum, groin, neck, or axilla. To date, CFPT has not been described in the pleura. The authors reviewed the clinical, radiologic, and pathologic features of three cases. A 23-year old woman and 34-year old man who presented with chest pain, and a 28-year old woman without chest symptoms were found to have a pleural mass on chest radiographs. Computed tomography (CT) scans of each patient revealed pleural-based nodular masses with central areas of increased attenuation due to calcifications. Each lesion consisted of circumscribed, but unencapsulated masses of hyalinized collagenous fibrotic tissue interspersed with lymphoplasmacytic infiltrates and calcifications, many of which had psammomatous features. The lesions were limited to the pleura and did not involve the underlying lung parenchyma. Electron microscopy in one case showed fibroblasts scattered in dense collagenous tissue. Calcifying fibrous pseudotumor is distinct from other pleural lesions such as fibrous tumor of pleura, calcified granulomas, calcified pleural plaques, and chronic fibrous pleuritis as well as intrapulmonary lesions such as hyalinizing granuloma, inflammatory pseudotumor, and amyloid. As in the soft tissues. Local excision appears adequate therapy for CFPT of the pleura. If these lesions behave in a similar fashion to CFPT of soft tissues, one might expect a low frequency of local recurrence. C1 ARMED FORCES INST PATHOL,DEPT PULM & MEDIASTINAL PATHOL,WASHINGTON,DC 20306. UNIV ALABAMA,MED CTR,DEPT PATHOL,BIRMINGHAM,AL 35294. WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT PULM MED,WASHINGTON,DC. DUKE UNIV,MED CTR,DEPT PATHOL,DURHAM,NC 27710. DUKE UNIV,MED CTR,DEPT RADIOL,DURHAM,NC 27710. RI McAdams, Holman/N-8218-2015 OI McAdams, Holman/0000-0002-7044-3320 NR 18 TC 62 Z9 65 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0002-9173 J9 AM J CLIN PATHOL JI Am. J. Clin. Pathol. PD FEB PY 1996 VL 105 IS 2 BP 189 EP 194 PG 6 WC Pathology SC Pathology GA TU716 UT WOS:A1996TU71600010 PM 8607443 ER PT J AU Hoge, CW Bodhidatta, L Echeverria, P Deesuwan, M Kitporka, P AF Hoge, CW Bodhidatta, L Echeverria, P Deesuwan, M Kitporka, P TI Epidemiologic study of Vibrio cholerae O1 and O139 in Thailand: At the advancing edge of the eighth pandemic SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Article DE cholera; epidemiologic factors; risk factors; Vibrio cholerae; Vibrio infections ID TOXIN AB Vibrio cholerae O139 Bengal emerged on the Indian subcontinent in late 1992 and was first recognized in Thailand in 1993. To characterize the epidemiology of this disease, a hospital-based case-control study was conducted in Samutsakom, a port city 30 km southwest of Bangkok, Between November 15, 1993, and June 3, 1994, 366 patients were confirmed to have cholera by culture, including 165 (45%) with O139 Bengal, 191 (52%) with O1 Ogawa, and 10 (3%) with both serogroups, During the same time period the previous year, 319 culture-confirmed cholera cases occurred, all serogroup O1. Questionnaires were obtained from 105 patients with O139 Bengal and 103 with O1 infections; for each case patient, two asymptomatic age- and sex-matched control persons were selected, Of the patients with O139 Bengal infections, 93% were adults (greater than or equal to 15 years) compared with 92% of patients with O1 infections, Risk factors for cholera identified by case-control comparisons were similar for the two serogroups and included consumption of untreated water, uncooked seafood, and food served at group gatherings, V. cholerae O139 Bengal has emerged in Thailand as a cause of endemic cholera, with epidemiologic features and incidence similar to those of the preexisting O1 strain. C1 ARMED FORCES RES INST MED SCI,DEPT BACTERIOL IMMUNOL & MOLEC GENET,BANGKOK 10400,THAILAND. SAMUTSAKOM HOSP,SAMUTSAKOM,THAILAND. NR 19 TC 19 Z9 20 U1 0 U2 1 PU AMER J EPIDEMIOLOGY PI BALTIMORE PA 624 N BROADWAY RM 225, BALTIMORE, MD 21205 SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD FEB 1 PY 1996 VL 143 IS 3 BP 263 EP 268 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA TR349 UT WOS:A1996TR34900007 PM 8561160 ER PT J AU Furgerson, JL Vukelja, SJ Baker, WJ ORourke, TJ AF Furgerson, JL Vukelja, SJ Baker, WJ ORourke, TJ TI Acute myeloid leukemia evolving from essential thrombocythemia in two patients treated with hydroxyurea SO AMERICAN JOURNAL OF HEMATOLOGY LA English DT Article DE acute myeloid leukemia; essential thrombocythemia; hydroxyurea; thrombocytosis; therapy-associated leukemia; chromosomal aberrations ID POLYCYTHEMIA-VERA; MYELODYSPLASTIC SYNDROME; TRANSFORMATION; THERAPY; DISEASE; SECONDARY; DRUG AB Essential thrombocythemia (ET) is an uncommon myeloproliferative disorder, which is thought to develop from a multipotent stem cell. Like other myeloproliferative diseases, ET is associated with an increased risk of development of acute leukemia (AL). However, the large majority of cases of leukemic transformation in ET are thought to be related to prior therapy, usually radioactive phosphorous or alkylating chemotherapy, and the development of AL in ET is extremely rare in the untreated patient In this report, two cases of ET which evolved into AL without prior exposure to radiation or alkylating agents, and which were treated with long-term hydroxyurea therapy, are described, The first case had cytogenetic changes in the bone marrow suggestive of therapy-associated leukemia, and the second developed myelodysplastic syndrome on therapy which was likely chemotherapy-induced and led to acute leukemia. Prolonged used of hydroxyurea in patients with ET may lead to therapy-associated acute leukemia. (C) 1996 Wiley-Liss, Inc. RP Furgerson, JL (reprint author), BROOKE ARMY MED CTR,DEPT MED,FT SAM HOUSTON,TX 78234, USA. NR 30 TC 32 Z9 32 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0361-8609 J9 AM J HEMATOL JI Am. J. Hematol. PD FEB PY 1996 VL 51 IS 2 BP 137 EP 140 DI 10.1002/(SICI)1096-8652(199602)51:2<137::AID-AJH7>3.0.CO;2-Z PG 4 WC Hematology SC Hematology GA TT553 UT WOS:A1996TT55300007 PM 8579054 ER PT J AU Watters, MR Burton, BS Turner, GE Cannard, KR AF Watters, MR Burton, BS Turner, GE Cannard, KR TI MR screening for brain stem compression in hypertension SO AMERICAN JOURNAL OF NEURORADIOLOGY LA English DT Article DE brain stem, magnetic resonance; hypertension ID MECHANISMS AB PURPOSE: To determine the clinical usefulness of MR imaging to screen for vascular compression of the lateral medulla, considered by some to be responsible for neurogenic hypertension. METHODS: MR images and clinical records of 120 adults who had received brain MR imaging for any reason were divided into two groups: group 1 (n = 60) consisted of patients with essential hypertension and group 2 (n = 60) included patients who lacked a diagnosis of hypertension, No patient manifested symptomatic cranial neuralgias. The root entry zone of cranial nerves IX and X into the left lateral medulla was examined by MR imaging for proximity to the ipsilateral vertebral artery or its branches. Images lacking any contact between visible vascular structures and the root entry zone were recorded as normal, Vascular compression was graded according to the degree of proximity to the root entry zone. Lateral medullary contact only (grade I), contact and depression (grade II), or lower brain ste;n displacement or rotation (grade III) of the root entry zone were recorded in both hypertensive and normotensive patients. Among hypertensive patients, additional data were gathered from electrocardiographic, echocardiographic, and urinary protein reports. RESULTS: We found compression in 34 (57%) of the patients from group 1 and in 33 (55%) of the patients from group 2, Compressions in group 1 were grade 1 in 22 (37%) of the patients, grade II in 8 (13%), and grade III in 4 (7%). Among group 2 patients, grade I compressions were found in 27 (45%), grade II in 4 (7%), and grade III in 2 (3%). There were no statistically significant differences in MR findings between the two groups, Among group 1 patients, MR grading did not predict end-organ changes in the heart (left axis deviation and left ventricular hypertrophy) or kidneys (proteinuria). CONCLUSION: Vascular compression of the root entry zone of cranial nerves IX and X into the left lateral medulla is not an adequate lesion to produce systemic hypertension. This finding is as common among normotensive patients as among hypertensive populations. Neither the presence nor the severity of changes in the root entry zone on MR images increases the occurrence of common end-organ responses in the heart or kidneys among hypertensive patients. MR screening is not warranted among hypertensive patients lacking symptomatic cranial neuralgias. C1 TRIPLER ARMY MED CTR,DEPT NEURORADIOL,HONOLULU,HI 96859. RP Watters, MR (reprint author), TRIPLER ARMY MED CTR,DEPT NEUROL,BOX 247,HONOLULU,HI 96859, USA. NR 27 TC 42 Z9 45 U1 0 U2 0 PU AMER SOC NEURORADIOLOGY PI OAK BROOK PA 2210 MIDWEST RD, OAK BROOK, IL 60521 SN 0195-6108 J9 AM J NEURORADIOL JI Am. J. Neuroradiol. PD FEB PY 1996 VL 17 IS 2 BP 217 EP 221 PG 5 WC Clinical Neurology; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA TW234 UT WOS:A1996TW23400004 PM 8938288 ER PT J AU Sood, SL Balaraman, V Finn, KC Britton, B Uyehara, CFT Easa, D AF Sood, SL Balaraman, V Finn, KC Britton, B Uyehara, CFT Easa, D TI Exogenous surfactants in a piglet model of acute respiratory distress syndrome SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Article ID END-EXPIRATORY PRESSURE; ALVEOLAR SURFACTANT; LUNG-FUNCTION; VENTILATION; RABBITS; FREQUENCY; INJURY; LAVAGE AB Evidence for surfactant dysfunction in acute respiratory distress syndrome (ARDS) suggests a role for exogenous surfactant which contains apoprotein for resistance to protein inhibition. We compared the effects of KL-4-Surfactant, an artificial preparation containing a synthetic 21 amino acid peptide with SP-B-like activity, with Exosurf(R), an artificial protein-free surfactant, and Survanta(R), a bovine protein-containing surfactant, in a saline lung lavage model of ARDS in neonatal piglets. Two sequential series of lung lavages were performed to lower Pa-O2 < 100 mm Hg, each followed by administration of surfactant or air and a 90-min observation period. Progressive lung injury was demonstrated by deterioration in pulmonary function, increasing bronchoalveolar lavage protein, and changes in histopathology. All surfactants improved oxygenation, although oxygenation was generally better with Survanta and KL-4-Surfactant. Further, Survanta and KL-4-Surfactant groups showed improvement in ventilation, with decreases in Pa-CO2 and increases in FRC. Only KL-4-Surfactant demonstrated greater pressure-volume characteristics and lower bronchoalveolar protein than those of Controls. We conclude that the physiologic effects of KL-4-Surfactant are more like Survanta in this model. We speculate that KL-4-Surfactant may improve pulmonary function, reduce alveolar protein leak, and thus be efficacious in the treatment of ARDS. C1 KAPIOLANI MED CTR WOMEN & CHILDREN,DEPT PEDIAT,JOHN A BURNS SCH MED,HONOLULU,HI 96826. TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96859. TRIPLER ARMY MED CTR,DEPT PATHOL,HONOLULU,HI 96859. NR 35 TC 19 Z9 24 U1 0 U2 1 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 1073-449X J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PD FEB PY 1996 VL 153 IS 2 BP 820 EP 828 PG 9 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA TT884 UT WOS:A1996TT88400053 PM 8564138 ER PT J AU Rattanarithikul, R Konishi, E Linthicum, KJ AF Rattanarithikul, R Konishi, E Linthicum, KJ TI Detection of Plasmodium vivax and Plasmodium falciparum circumsporozoite antigen in anopheline mosquitoes collected in southern Thailand SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID LINKED-IMMUNOSORBENT-ASSAY; SPOROZOITES; CULICIDAE; MALARIA; DIPTERA AB During a 13-month study on the ecology of malaria vectors in five villages in southern Thailand, Anopheles specimens collected on human-bait, bovid-bait, and in light traps were tested for the presence of Plasmodium vivax and P. falciparum circumsporozoite antigen by enzyme-linked immunosorbent assay. Plasmodium vivax antigen was detected in seven specimens and P. falciparum in 21 specimens, together representing 0.4% of the 7,938 specimens tested. In one village, Palao-U, circumsporozoite antigen was detected in 16 (0.7%) of the 2,196 specimens tested. In this village, combined rates of infection with P. falciparum and P. vivax were 0.6% for An. minimus, 1.1% for An. sawadwongporni, and 1.5% for An. maculatus. Circumsporozoite antigen was also detected in An. dirus, An. nivipes, An. barbirostris group, and An. hyrcanus group specimens. Combined P. fulciparum and P. virax entomologic inoculation rates in the wet season (March-October) were 0.05 for An. minimus, An. maculatus, and An. dirus, but 0 for An. sawadwongporni. Rates were higher in the dry season (November-February): 0.26 for An. minimus, 0.13 for An. maculatus, 0.13 for An. sawadwongporni, and 0 for An. dines. The vectorial capacity, calculated based on human biting rate and rate of survival, of An. minimus during the dry season was more than two-fold higher than that of An. maculatus, the species with the second highest vectorial capacity. C1 ARMED FORCES RES INST MED SCI, USA MED COMPONENT, DEPT ENTOMOL, BANGKOK 10400, THAILAND. KOBE UNIV, SCH MED, DEPT MED ZOOL, KOBE 650, JAPAN. NR 24 TC 53 Z9 59 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD FEB PY 1996 VL 54 IS 2 BP 114 EP 121 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA TZ760 UT WOS:A1996TZ76000002 PM 8619432 ER PT J AU VanCuyckGandre, H Caudill, JD Zhang, HY Longer, CF Molinie, C Roue, R Deloince, R Coursaget, P Mamouth, NN Buisson, Y AF VanCuyckGandre, H Caudill, JD Zhang, HY Longer, CF Molinie, C Roue, R Deloince, R Coursaget, P Mamouth, NN Buisson, Y TI Short report: Polymerase chain reaction detection of hepatitis E virus in north African fecal samples SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article AB Epidemics of enterically-transmitted non-A, non-B hepatitis were described in 1983-1984 involving French soldiers in Chad and in 1979-1980 in residents of Algeria. Hepatitis E virus (HEV) was subsequently implicated by serology. In this study, the presence of HEV in patient stool specimens from both outbreaks and from sporadic cases in residents of Chad (1994) was documented. This virus was detected in fecal suspensions by antibody capture of the virus and reverse transcriptase-polymerase chain reaction amplification of the viral RNA in the 3' end of open reading frame 2. Two of five epidemic cases from Chad (1983-1984) were positive, as well as one of five sporadic cases from Chad (1994), and two of three epidemic cases from Algeria (1979-1980). Of these 13 patients, 12 had detectable anti-HEV IgG in their serum. These results confirmed that HEV was the cause of hepatitis in at least five of these 13 patients. C1 SERV SANTE ARMEES,CTR RECH,LA TRONCHE,FRANCE. HOP INSTRUCT ARMEES VAL DE GRCE,PARIS,FRANCE. HOP INSTRUCT ARMEES VAL DE BEGIN,ST MANDE,FRANCE. FAC PHARM,TOURS,FRANCE. HOP CENT,NDJAMENA,CHAD. RP VanCuyckGandre, H (reprint author), WALTER REED ARMY INST RES,DEPT VIRUS RES,WASHINGTON,DC 20307, USA. NR 8 TC 9 Z9 9 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD FEB PY 1996 VL 54 IS 2 BP 134 EP 135 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA TZ760 UT WOS:A1996TZ76000005 PM 8619435 ER PT J AU Turell, MJ Presley, SM Gad, AM Cope, SE Dohm, DJ Morrill, JC Arthur, RR AF Turell, MJ Presley, SM Gad, AM Cope, SE Dohm, DJ Morrill, JC Arthur, RR TI Vector competence of Egyptian mosquitoes for Rift Valley fever virus SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID HOST-FEEDING PATTERNS; CULEX-PIPIENS; CULICIDAE; DIPTERA; TRANSMISSION; DISSEMINATION; GOVERNORATE AB Reintroduction of Rift Valley fever (RVF) into Egypt in 1993 raised concerns about the potential for Egyptian mosquitoes to transmit the virus. We evaluated the ability of Aedes caspius, Culex pipiens, Cx. antennatus, Cx. perexiguus, Cx. poicilipes, and Anopheles pharoensis collected in the Aswan area and Cx. pipiens collected in the Nile Delta to transmit RVF virus. All mosquito species tested were susceptible to RVF virus infection, with An. pharoensis and Ae. caspius being the most sensitive to infection. However, none of 12 An. pharoensis, including 10 with a disseminated infection, transmitted RVF virus by bite. In contrast, nearly all Cx. pipiens (87%, n = 15) and Cx. perexiguus (90%, n = 10) with a disseminated infection transmitted virus. Overall transmission rates for mosquitoes exposed to hamsters with a viremia greater than or equal to 10(7) plaque-forming units/ml were Ae. caspius, 20% (n = 5); Cx. pipiens, 7% (n = 102); Cx. antennatus, 7% (n = 30); Cx. perexiguus, 11% (n = 9); and An. pharoensis, 0% (n = 7). Based on abundance, susceptibility to infection, ability to transmit virus, and feeding behavior, Ae. caspius appeared to be the most efficient vector of the Egyptian mosquitoes evaluated. While less susceptible than Ae. caspius, Cx. pipiens, Cx. antennatus, and Cx. perexiguus were also potential vectors during this RVF outbreak in Egypt. C1 USN,MED RES UNIT 3,CAIRO,EGYPT. AIN SHAMS UNIV,RES & TRAINING CTR VECTORS DIS,CAIRO,EGYPT. JOHNS HOPKINS UNIV,SCH PUBL HLTH,DEPT MOLEC MICROBIOL & IMMUNOL,BALTIMORE,MD. RP Turell, MJ (reprint author), USA,MED RES INST INFECT DIS,APPL RES DIV,DEPT EPIDEMIOL,FT DETRICK,MD 21702, USA. NR 20 TC 55 Z9 58 U1 0 U2 6 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD FEB PY 1996 VL 54 IS 2 BP 136 EP 139 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA TZ760 UT WOS:A1996TZ76000006 PM 8619436 ER PT J AU Looareesuwan, S Kyle, DE Viravan, C Vanijanonta, S Wilairatana, P Wernsdorfer, WH AF Looareesuwan, S Kyle, DE Viravan, C Vanijanonta, S Wilairatana, P Wernsdorfer, WH TI Clinical study of pyronaridine for the treatment of acute uncomplicated falciparum malaria in Thailand SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID PLASMODIUM-FALCIPARUM; MEFLOQUINE AB One hundred one adult patients with acute uncomplicated falciparum malaria were treated with pyronaridine. All patients were admitted to the Bangkok Hospital for Tropical Diseases for 28 days to exclude reinfection. Sixty-nine patients (Group I) received pyronaridine 1,200 mg over a three-day period and 32 patients (Group II) received 1,800 mg of pyronaridine over a five-day period, Cure rates for the two groups were 63% (38 of 60) for Group I and 88% (23 of 26) for Group II (P < 0.05). No RII or RIII type response was seen. Mean fever and parasite clearance times were not significantly different in the two groups. The drug was well-tolerated. In vitro drug sensitivity tests of the paired parasite isolates obtained prior to treatment and after recrudescence indicated that the Plasmodium falciparum isolates of the successfully treated patients had a lower mean concentration for 50% inhibition of growth (IC50) and a much narrower range of the individual IC50 values (15.69 +/- 3.82 ng/ml [mean +/- SD]) as compared with those from the recrudescence cases (22.98 +/- 12.05 ng/ml). Nevertheless, there was no evidence of an increase of the IC50 and IC95 values after recrudescence. The results of the study show that pyronaridine alone at a total dose of 1,800 mg given over five days is well-tolerated in patients suffering from acute uncomplicated malaria and has evident activity against multidrug-resistant falciparum malaria. However, it cannot be recommended for use in Thailand as long as the recrudescence rate is as high as 12%. Further studies of its combinations with other antimalarial drugs are needed. C1 MAHIDOL UNIV,FAC TROP MED,BANGKOK HOSP TROP DIS,BANGKOK 10400,THAILAND. USA,MED COMPONENT,ARMED FORCES RES INST MED SCI,DEPT IMMUNOL & PARASITOL,BANGKOK,THAILAND. UNIV VIENNA,FAC MED,INST SPECIF PROPHYLAXIS & TROP MED,VIENNA,AUSTRIA. RP Looareesuwan, S (reprint author), MAHIDOL UNIV,DEPT CLIN TROP MED,420-6 RAJVITHI RD,BANGKOK 10400,THAILAND. NR 20 TC 49 Z9 50 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD FEB PY 1996 VL 54 IS 2 BP 205 EP 209 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA TZ760 UT WOS:A1996TZ76000019 PM 8619449 ER PT J AU Vangel, MG AF Vangel, MG TI Confidence intervals for a normal coefficient of variation SO AMERICAN STATISTICIAN LA English DT Article DE chi-squared approximation; noncentral t distribution; McKay's approximation AB This article presents an analysis of the small-sample distribution of a class of approximate pivotal quantities for a normal coefficient of variation that contains the approximations of McKay, David, the ''naive'' approximate interval obtained by dividing the usual confidence interval on the standard deviation by the sample mean, and a new interval closely related to McKay. For any approximation in this class, a series is given for e(t), the difference between the cdf's of the approximate pivot and the reference distribution. Let ii denote the population coefficient of variation. For McKay, David, and the ''naive'' interval e(t) = O(k(2)), while for the new procedure e(t) = O(k(4)). C1 USA,RES LAB,WATERTOWN,MA 02172. RP Vangel, MG (reprint author), NIST,DIV STAT ENGN,GAITHERSBURG,MD 20899, USA. NR 7 TC 72 Z9 72 U1 2 U2 8 PU AMER STATIST ASSN PI ALEXANDRIA PA 1429 DUKE ST, ALEXANDRIA, VA 22314 SN 0003-1305 J9 AM STAT JI Am. Stat. PD FEB PY 1996 VL 50 IS 1 BP 21 EP 26 DI 10.2307/2685039 PG 6 WC Statistics & Probability SC Mathematics GA UN109 UT WOS:A1996UN10900005 ER PT J AU Pack, MS Thomas, RS AF Pack, MS Thomas, RS TI Axillary lymph node dissection: Does it have a role in primary breast cancer? SO AMERICAN SURGEON LA English DT Article AB The role of elective lymph node dissection has been increasingly questioned for the treatment of primary breast cancer. In an attempt to evaluate whether or not axillary lymph node dissection is of value in early breast cancer, a retrospective review of all breast cancers treated at Eisenhower Army Medical Center was conducted. During that time, 434 patients with breast cancer were treated. Eighty-six of those patients had lesions that were 2.0 cm or smaller. Eighty-one patients underwent axillary lymph node dissection. Twenty-four patients were found to have positive axillary nodes (28%). If the patients were further divided into those with lesions 1.0 centimeters or less versus 1.1-2.0 cm, the incidence of node positivity was 19 per cent and 35 per cent, respectively. Of the patients who underwent axillary lymph node dissection, 60 per cent of those whose lymph nodes were negative received no further treatment whereas those whose lymph nodes were positive received additional therapy 92 per cent of the time. An additional 8 per cent of the node-negative patients received radiation therapy as the only added therapy after segmental mastectomy with axillary lymph node dissection. Our study demonstrates, or at least suggests, that node positivity did influence subsequent therapy. In addition, the relatively high incidence of positive axillary nodes (28%) in these early breast cancers supports the potential therapeutic benefit of axillary node dissection. RP Pack, MS (reprint author), EISENHOWER ARMY MED CTR,DEPT GEN SURG,USA MED CORPS,FT GORDON,GA 30905, USA. NR 7 TC 5 Z9 5 U1 0 U2 0 PU SOUTHEASTERN SURGICAL CONGRESS PI ATLANTA PA 1776 PEACHTREE RD, NW., SUITE 410N, ATLANTA, GA 30309-2352 SN 0003-1348 J9 AM SURGEON JI Am. Surg. PD FEB PY 1996 VL 62 IS 2 BP 159 EP 161 PG 3 WC Surgery SC Surgery GA TR336 UT WOS:A1996TR33600014 PM 8554194 ER PT J AU Thwaites, BK AF Thwaites, BK TI Ketorolac and platelet function - Response SO ANESTHESIA AND ANALGESIA LA English DT Letter ID ANESTHESIA; HUMANS RP Thwaites, BK (reprint author), BROOKE ARMY MED CTR,ANESTHESIA & OPERAT SERV,FT SAM HOUSTON,TX 78234, USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD FEB PY 1996 VL 82 IS 2 BP 428 EP 429 DI 10.1097/00000539-199602000-00047 PG 2 WC Anesthesiology SC Anesthesiology GA TT440 UT WOS:A1996TT44000047 ER PT J AU Topf, AI AF Topf, AI TI Complication associated with the use of an oral airway SO ANESTHESIOLOGY LA English DT Letter RP Topf, AI (reprint author), TRIPLER ARMY MED CTR,DEPT ANESTHESIOL,CDR,MCHK,DSA,1 JARRETT WHITE RD,HONOLULU,HI 96859, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD FEB PY 1996 VL 84 IS 2 BP 485 EP 485 DI 10.1097/00000542-199602000-00048 PG 1 WC Anesthesiology SC Anesthesiology GA TU976 UT WOS:A1996TU97600049 PM 8602695 ER PT J AU Chan, DS Demers, DM Bass, JW AF Chan, DS Demers, DM Bass, JW TI Antimicrobial liquid formulations: A blind taste comparison of three brands of penicillin VK and three brands of amoxicillin SO ANNALS OF PHARMACOTHERAPY LA English DT Article AB OBJECTIVE: To rate the perception of taste, texture, smell and aftertaste of various brands of penicillin VK and amoxicillin. DESIGN: Oral, Liquid formulations of three brands of penicillin VK (PenVee K, V-Cillin-K, VeeTids) and three brands of amoxicillin (Amoxil, Trimox, Wymox) were evaluated for smell, texture, taste, and aftertaste by 30 volunteers in a blind study. Each category was scored on a scale of 1 to 5. The order in which the drugs were sampled was randomized for the first three groups of five participants. The order then was reversed for the remaining three groups of participants. SETTING: A 537-bed US Army teaching hospital. PARTICIPANTS: Participants included 30 healthy adult volunteers from the Departments of Pediatrics, Nursing, and Pharmacy. MAIN OUTCOME MEASURES: Drugs received cumulative scores in each category, as well as an overall total score ranking. The data were analyzed using one-way ANOVA for repeated measures with a post hoc Duncan's multiple range test to determine significant differences between individual means. RESULTS: Overall, Trimox and Amoxil scored significantly higher than the remaining drugs. Although V-Cillin-K scored highest in the smell category, its score was significantly below those of Trimox and Amoxil in the texture, taste, aftertaste, and overall categories. Overall, the three penicillin VK solutions scored lower than the three amoxicillin suspensions, with PenVee K ranking the lowest. Among the penicillin VK solutions, V-Cillin-K scored significantly higher overall than the other two penicillin VK solutions. CONCLUSIONS: Overall, all three amoxicillin oral, liquid suspensions that were studied scored significantly better than the three penicillin VK solutions. C1 UNIV PACIFIC,STOCKTON,CA 95211. USA,TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859. RP Chan, DS (reprint author), USA,TRIPLER ARMY MED CTR,DEPT PHARM,MCHK PY,1 JARRETT WHITE RD,HONOLULU,HI 96859, USA. NR 7 TC 5 Z9 5 U1 0 U2 0 PU HARVEY WHITNEY BOOKS CO PI CINCINNATI PA PO BOX 42696, CINCINNATI, OH 45242 SN 1060-0280 J9 ANN PHARMACOTHER JI Ann. Pharmacother. PD FEB PY 1996 VL 30 IS 2 BP 130 EP 132 PG 3 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA TV831 UT WOS:A1996TV83100003 PM 8835043 ER PT J AU Cortese, LM Soucy, DM Endy, TP AF Cortese, LM Soucy, DM Endy, TP TI Trimethoprim/sulfamethoxazole desensitization SO ANNALS OF PHARMACOTHERAPY LA English DT Discussion ID ACQUIRED IMMUNODEFICIENCY SYNDROME; PNEUMOCYSTIS-CARINII PNEUMONIA; TRIMETHOPRIM-SULFAMETHOXAZOLE; CO-TRIMOXAZOLE; HIV-INFECTION C1 WALTER REED ARMY MED CTR,HENRY M JACKSON FDN ADVANCEMENT MIL MED,WASHINGTON,DC 20307. UNIV MARYLAND,SCH PHARM,BALTIMORE,MD 21201. NR 10 TC 9 Z9 10 U1 0 U2 0 PU HARVEY WHITNEY BOOKS CO PI CINCINNATI PA PO BOX 42696, CINCINNATI, OH 45242 SN 1060-0280 J9 ANN PHARMACOTHER JI Ann. Pharmacother. PD FEB PY 1996 VL 30 IS 2 BP 184 EP 186 PG 3 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA TV831 UT WOS:A1996TV83100014 PM 8835054 ER PT J AU Bangs, MJ Rusmiarto, S Anthony, RL Wirtz, RA Subianto, DB AF Bangs, MJ Rusmiarto, S Anthony, RL Wirtz, RA Subianto, DB TI Malaria transmission by Anopheles punctulatus in the highlands of Irian Jaya, Indonesia SO ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY LA English DT Article ID PLASMODIUM-VIVAX SPOROZOITES; LINKED-IMMUNOSORBENT-ASSAY; CIRCUMSPOROZOITE PROTEIN; MONOCLONAL-ANTIBODY; NEW-GUINEA; MOSQUITOS; POPULATION; VARIANT; ELISA; RATES AB A 21-month (1991-1992) assessment of malaria and the relative contribution of Anopheles punctulatus and An. koliensis to its transmission was conducted in Oksibil, a highland community in Irian Jaya, Indonesia. Nearly all (98%) of the 2577 Anopheles from indoor or outdoor human-landing collections were An. punctulatus. Nineteen (0.75%) of the 2518 An. punctulatus tested were positive when tested for malaria circumsporozoite protein (CSP) by ELISA: nine (45% of positives) for Plasmodium vivax-210, six (30%) for Plasmodium falciparum, three (15%) for P. vivax-247 and two (10%) for P. malariae. One mosquito was positive for both P. vivax 210 and P. falciparum. All 59 An. koliensis tested were negative. All mosquitoes positive for CSP were from indoor collections, 89% from the main houses and the remaining 11% from the traditional dwellings (bokams). These findings are discussed with respect to highland malaria epidemiology and transmission in the Oksibil Valley. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307. DEPT HLTH,JAYAPURA 99017,INDONESIA. RP Bangs, MJ (reprint author), USN,MED RES UNIT 2,PUBLICAT OFF,BOX 3,APO,AP 96520, USA. NR 38 TC 14 Z9 14 U1 0 U2 1 PU W B SAUNDERS CO LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0003-4983 J9 ANN TROP MED PARASIT JI Ann. Trop. Med. Parasitol. PD FEB PY 1996 VL 90 IS 1 BP 29 EP 38 PG 10 WC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine SC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine GA TU809 UT WOS:A1996TU80900003 PM 8729625 ER PT J AU Yu, H Bruno, JG AF Yu, H Bruno, JG TI Immunomagnetic-electrochemiluminescent detection of Escherichia coli O157 and Salmonella typhimurium in foods and environmental water samples SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID LABELED ANTIBODY PROCEDURE; LATEX AGGLUTINATION; DNA; SEROTYPE; SEPARATION; 0157-H7; ASSAYS; FECES AB Hemorrhagic Escherichia coli O157:H7 strains and other virulent enteric pathogens can pose a serious health threat in tainted meats, poultry, and even drinking water. Traditional culture-based methods for assay of enteric pathogens in foods and water sources are relatively slow, and results can be ambiguous, Immunomagnetic separation (IMS) and detection methods have been investigated and appear promising for rapid bacterial assay of foods and environmental samples, In this work, a commercial sensor which combines IMS with electrochemiluminescence (ECL) detection is evaluated for detection of E, coli O157 and Salmonella typhimurium in foods and fomites, Results indicate that detection limits are in the range of 100 to 1,000 bacteria per mi in pristine buffer for E, coli O157 and S, typhimurium, respectively, or 1,000 to 2,000 bacteria per ml in food samples (depending on the sample) and that total processing and assay time is rapid (<1 h) even in food samples, An immunologic ''hook'' or high-antigen-concentration prozone effect was observed above 10(4) and 10(5) bacteria per ml for E. coli O157 and S. typhimurium, respectively, IMS was accomplished in milk, juices, serum, supernatant fluids from ground beef, finely minced chicken, and fish suspensions as well as several freshwater sources and followed by ECL assay, Some samples, especially fish, gave unexpectedly high background ECL, Conversely, low ECL intensity was observed in nonfat and 2% fat milk samples, which appeared to be related to binding or entrapment of the antibody-coated magnetic beads by particulates in the milk, as revealed by microscopy. Results of this evaluation suggest the feasibility of immunomagnetic-ECL methodology for rapid, sensitive, and facile preliminary screening of various foods and fomites for the presence of virulent enteric pathogens. C1 USAF,ARMSTRONG LAB,EQC,ENVIRON DIRECTORATE,APPL RES ASSOCIATES,TYNDALL AFB,FL 32403. USA,EDGEWOOD RES DEV & ENGN CTR,SYST RES LABS INC,ABERDEEN PROVING GROUND,MD 21010. NR 33 TC 183 Z9 191 U1 1 U2 30 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD FEB PY 1996 VL 62 IS 2 BP 587 EP 592 PG 6 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA TT690 UT WOS:A1996TT69000043 PM 8593058 ER PT J AU Maly, T Petzold, LR AF Maly, T Petzold, LR TI Numerical methods and software for sensitivity analysis of differential-algebraic systems SO APPLIED NUMERICAL MATHEMATICS LA English DT Article; Proceedings Paper CT Workshop on the Method of Lines for Time-Dependent Problems CY MAY 31-JUN 04, 1995 CL LEXINGTON, KY SP Natl Sci Fdn, Univ Kentucky, Ctr Computat Sci, So Methodist Univ, Dedman Coll, Colorado Sch Mines AB In this paper, we present some new algorithms and software for sensitivity analysis of differential-algebraic equation (DAE) systems. The algorithms have several novel features, which are described and analyzed. The codes, which are extensions of DASSL and DASPK, are easy to use, highly efficient, and well suited for large-scale problems. C1 UNIV MINNESOTA, DEPT COMP SCI, MINNEAPOLIS, MN 55455 USA. UNIV MINNESOTA, ARMY HIGH PERFORMANCE COMP RES CTR, MINNEAPOLIS, MN 55455 USA. MCHUGH FREEMAN & ASSOCIATES INC, WAUKESHA, WI 53186 USA. NR 13 TC 116 Z9 120 U1 0 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-9274 J9 APPL NUMER MATH JI Appl. Numer. Math. PD FEB PY 1996 VL 20 IS 1-2 BP 57 EP 79 DI 10.1016/0168-9274(95)00117-4 PG 23 WC Mathematics, Applied SC Mathematics GA UF184 UT WOS:A1996UF18400005 ER PT J AU Williamson, CK Pastel, RL Sausa, RC AF Williamson, CK Pastel, RL Sausa, RC TI Detection of ambient NO by laser-induced photoacoustic spectrometry using A(2)Sigma(+)-X(2)Pi (0,0) transitions near 226 nm SO APPLIED SPECTROSCOPY LA English DT Article DE photoacoustic spectrometry; laser spectroscopy; NO AB Trace concentrations of NO are detected under ambient conditions by laser-induced photoacoustic spectroscopy. NO is excited via its A(2) Sigma(+)-X(2) Pi (0,0) band with radiation near 226 nm, and the subsequent heat released is monitored by a microphone. Rotationally resolved photoacoustic spectra are recorded and fit with the use of a multiparameter computer simulation based on a Boltzmann distribution. Transition probabilities and rotational energies are used as input parameters. The effect of buffer gas pressure, buffer gas, laser energy, and NO concentration on the PA signal is investigated both experimentally and by model calculations. Limits of detection (LODs) of 1.2, 2.8, and 4.9 ppm are obtained for NO in Ar, N-2, and air, respectively. The ultimate sensitivity of this approach is greater with LODs projected in the low-ppb range by utilizing higher laser energies and an improved system design. The results are compared with those of previous studies using complementary laser-based spectroscopic techniques. C1 USA,RES LAB,AMSRL,WT,PC,ABERDEEN PROVING GROUND,MD 21005. NR 27 TC 10 Z9 10 U1 0 U2 2 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA PO BOX 1438, FREDERICK, MD 21701 SN 0003-7028 J9 APPL SPECTROSC JI Appl. Spectrosc. PD FEB PY 1996 VL 50 IS 2 BP 205 EP 210 DI 10.1366/0003702963906474 PG 6 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA TV879 UT WOS:A1996TV87900013 ER PT J AU Jaax, NK Davis, KJ Geisbert, TJ Vogel, P Jaax, GP Topper, M Jahrling, PB AF Jaax, NK Davis, KJ Geisbert, TJ Vogel, P Jaax, GP Topper, M Jahrling, PB TI Lethal experimental infection of rhesus monkeys with Ebola-Zaire (Mayinga) virus by the oral and conjunctival route of exposure SO ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE LA English DT Article ID HEMORRHAGIC-FEVER; UNITED-STATES; DISEASE AB Objective.-The source of infection or mode of transmission of Ebola virus to human index cases of Ebola fever has not been established. Field observations in outbreaks of Ebola fever indicate that secondary transmission of Ebola virus is linked to improper needle hygiene, direct contact with infected tissue or fluid samples, and close contact with infected patients. While it is presumed that the virus infects through either breaks in the skin or contact with mucous membranes, the only two routes of exposure that have been experimentally validated are parenteral inoculation and aerosol inhalation. Epidemiologic evidence suggests that aerosol exposure is not an important means of virus transmission in natural outbreaks of human Ebola fever; this study was designed to verify that Ebola virus could be effectively transmitted by oral or conjunctival exposure in nonhuman primates. Materials and Methods.-Adult rhesus monkeys (Macaca mulatta) were exposed to Ebola-Zaire (Mayinga) virus orally (N = 4), conjunctivally (N = 4), or by intramuscular Inoculation (N = 1, virus-positive control). Results.-Four of four monkeys exposed by the conjunctival route, three of four monkeys exposed by the oral route, and the intramuscularly inoculated positive control monkey (one of one) were successfully infected with Elbola-Zaire (Mayinga). Seven monkeys died of Ebola fever between days 7 and 8 postexposure. One monkey was given aggressive supportive therapy and a platelet transfusion; it lived until day 12 postexposure. Conclusions.-Findings in this study experimentally confirm that Ebola virus can be effectively transmitted via the oral or conjunctival route of exposure in nonhuman primates. RP Jaax, NK (reprint author), USA,MED RES INST INFECT DIS,DIV PATHOL,FT DETRICK,MD 21702, USA. NR 37 TC 153 Z9 159 U1 1 U2 20 PU COLLEGE AMER PATHOLOGISTS PI NORTHFIELD PA C/O KIMBERLY GACKI, 325 WAUKEGAN RD, NORTHFIELD, IL 60093-2750 SN 0003-9985 J9 ARCH PATHOL LAB MED JI Arch. Pathol. Lab. Med. PD FEB PY 1996 VL 120 IS 2 BP 140 EP 155 PG 16 WC Medical Laboratory Technology; Medicine, Research & Experimental; Pathology SC Medical Laboratory Technology; Research & Experimental Medicine; Pathology GA TV905 UT WOS:A1996TV90500005 PM 8712894 ER PT J AU Davis, KJ Fritz, DL Pitt, ML Welkos, SL Worsham, PL Friedlander, AM AF Davis, KJ Fritz, DL Pitt, ML Welkos, SL Worsham, PL Friedlander, AM TI Pathology of experimental pneumonic plague produced by fraction 1-positive and fraction 1-negative Yersinia pestis in African green monkeys (Cercopithecus aethiops) SO ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE LA English DT Article ID MUCOSAL IMMUNE-SYSTEM; STREPTOCOCCUS-PNEUMONIAE; HOST DEFENSE AB Objective.-The protein capsule of Yersinia pestis, known as Fraction 1 or F1, is a protective immunogen and is an assumed, but not proven, virulence factor. Our objectives were to determine if inhaled F1-negative and/or F1-positive strains of Y pestis were virulent in the African green monkey and, if so, to differentiate F1-negative from F1-positive monkeys. Because F1-negative strains have been isolated from natural sources and have caused experimental fatal disease, we felt that this information was crucial to the development of future vaccines and diagnostic tests. Materials and Methods.-Adult African green monkeys were exposed by aerosol to F1-positive (CO92, n = 15) or F1-negative (C092-C12, n = 6; Java-9, n = 2) Y pestis strains. Results.-All monkeys died 4 to 10 days postexposure and had lesions consistent with primary pneumonic plague. Antibodies to Fl antigen and other Y pestis antigens allowed us to differentiate F1-positive from F1-negative Y pestis strains in fixed tissues. Conclusions.-ln this study, F1 antigen was not a required virulence factor. Therefore, there may be a need for vaccines and diagnostic assays that are not solely based on the f1 antigen. C1 USA,MED RES INST INFECT DIS,DIV TOXICOL,FT DETRICK,MD 21702. USA,MED RES INST INFECT DIS,BACTERIOL DIV,FT DETRICK,MD 21702. RP Davis, KJ (reprint author), USA,MED RES INST INFECT DIS,DIV PATHOL,FT DETRICK,MD 21702, USA. NR 38 TC 111 Z9 115 U1 0 U2 6 PU COLLEGE AMER PATHOLOGISTS PI NORTHFIELD PA C/O KIMBERLY GACKI, 325 WAUKEGAN RD, NORTHFIELD, IL 60093-2750 SN 0003-9985 J9 ARCH PATHOL LAB MED JI Arch. Pathol. Lab. Med. PD FEB PY 1996 VL 120 IS 2 BP 156 EP 163 PG 8 WC Medical Laboratory Technology; Medicine, Research & Experimental; Pathology SC Medical Laboratory Technology; Research & Experimental Medicine; Pathology GA TV905 UT WOS:A1996TV90500006 PM 8712895 ER PT J AU Vogel, P Abplanalp, D Kell, W Ibrahim, MS Downs, MB Pratt, WD Davis, KJ AF Vogel, P Abplanalp, D Kell, W Ibrahim, MS Downs, MB Pratt, WD Davis, KJ TI Venezuelan equine encephalitis in BALB/c mice - Kinetic analysis of central nervous system infection following aerosol or subcutaneous inoculation SO ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE LA English DT Article ID OLFACTORY PATHWAYS; VIRUS-INFECTION; ENCEPHALOMYELITIS VIRUS; MURINE CORONAVIRUS; AXONAL-TRANSPORT; CDNA CLONE; PATHOGENESIS; SPREAD; MOUSE; HAMSTERS AB Objective-To investigate the routes of entry of Venezuelan equine encephalitis (VEE) virus into the brain, we infected BALB/c mice with a virulent strain (V3000) by aerosol or subcutaneous inoculation. Methods.-lmmunohistochemistry and in situ hybridization methods were used to detect VEE virus in tissues taken at daily intervals postinfection. Results.-ln both groups, virus in the brain first appeared in olfactory regions. Aerosol exposure caused early massive infection of olfactory epithelium, which developed into bilaterally symmetrical infection of the olfactory nerves, olfactory bulbs, and lateral olfactory tracts by day 2 postinfection. After subcutaneous inoculation, VEE in the brain also appeared first in olfactory regions, but was not detected until day 3 postinfection. By day 4 postinfection, VEE viral infection had spread throughout the brain in both groups, Vascular endothelium and the choroid plexus remained uninfected during the entire study. Conclusions.-Our findings suggest that VEE virus, whether given by aerosol or subcutaneously, first enters the brain through the olfactory tract. C1 USA,MED RES INST INFECT DIS,DIAGNOST SYST DIV,FT DETRICK,MD 21702. USA,MED RES INST INFECT DIS,DIV VIROL,FT DETRICK,MD 21702. RP Vogel, P (reprint author), USA,MED RES INST INFECT DIS,DIV PATHOL,FT DETRICK,MD 21702, USA. NR 59 TC 46 Z9 47 U1 0 U2 2 PU COLLEGE AMER PATHOLOGISTS PI NORTHFIELD PA C/O KIMBERLY GACKI, 325 WAUKEGAN RD, NORTHFIELD, IL 60093-2750 SN 0003-9985 J9 ARCH PATHOL LAB MED JI Arch. Pathol. Lab. Med. PD FEB PY 1996 VL 120 IS 2 BP 164 EP 172 PG 9 WC Medical Laboratory Technology; Medicine, Research & Experimental; Pathology SC Medical Laboratory Technology; Research & Experimental Medicine; Pathology GA TV905 UT WOS:A1996TV90500007 PM 8712896 ER PT J AU Wesensten, NJ Balkin, TJ Belenky, GL AF Wesensten, NJ Balkin, TJ Belenky, GL TI Effects of daytime administration of zolpidem and triazolam on performance SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID BENZODIAZEPINES; MEMORY AB Background and Hypotheses: The performance-impairing effects of the short,acting imidazopyridine zolpidem (Ambien) were compared to those of triazolam (Halcion) following daytime administration. Methods: There were 70 male subjects who received oral zolpidem (5, 10 or 15 mg), triazolam (0.125, 0.25 or 0.5 mg), or placebo at 1000 hours. Performance on Logical Reasoning, Column Addition, and Repeated Acquisition (computerized tasks of the Waiter Reed Performance Assessment Battery) was assessed prior to drug administration, then at 1.5 h (estimated time of peak drug effects) and 6 h post-administration. Results: Number of trials completed (TC) and response time (RT) for correct answers on the Logical Reasoning (LR) and Column Addition (CA) tasks (expressed as percentage of pre-drug performance) were impaired by triazolam 0.5 mg (TC = 76.6 and 67.4% for LR and CA; RT = 182.1 and 127.0% for LR, CA) and zolpidem 15 mg (TC = 87.0 and 75.8% for LR, CA; RT = 198.7 and 161.8% for LR, CA) at 1.5 h post-administration. By 6 h post-administration, drug effects on performance had dissipated. Other doses of triazolam and zolpidem failed to impair performance significantly. Conclusions: These results indicate substantial performance impairment at estimated peak plasma concentrations of both triazolam and zolpidem, at or near doses coinciding with somnogenic efficacy. Thus, the present results suggest no advantage of benzodiazepine receptor-subtype-specific drugs (e.g., zolpidem). Rather, these results suggest that the performance-impairing effects of both drugs are dose-dependent and functionally coupled to their sleep-inducing properties. RP Wesensten, NJ (reprint author), WALTER REED ARMY INST RES,DEPT BEHAV BIOL,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307, USA. NR 21 TC 22 Z9 22 U1 1 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD FEB PY 1996 VL 67 IS 2 BP 115 EP 120 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA TT661 UT WOS:A1996TT66100004 PM 8834935 ER PT J AU Rabin, J AF Rabin, J TI Correction of subtle refractive error in aviators SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID DESIGN AB Optimal visual acuity is a requirement for piloting aircraft in military and civilian settings. While acuity can be corrected with glasses, spectacle wear can limit or even prohibit use of certain devices such as night vision goggles, helmet mounted displays, and/or chemical protective masks. Although current Army policy is directed toward selection of pilots who do not require spectacle correction for acceptable vision, refractive error can become manifest over time, making optical correction necessary. In such cases, contact lenses have been used quite successfully. Another approach is to neglect small amounts of refractive error, provided that vision is at least 20/20 without correction. This report describes visual findings in an aviator who was fitted with a contact lens to correct moderate astigmatism in one eye, while the other eye, with lesser refractive error, was left uncorrected. Advanced methods of testing visual resolution, including high and low contrast visual acuity and small letter contrast sensitivity, were used to compare vision achieved with full spectacle correction to that attained with the habitual, contact lens correction. Although the patient was pleased with his habitual correction, vision was significantly better with full spectacle correction, particularly on the small letter contrast test. Implications of these findings are considered. RP Rabin, J (reprint author), USA,AEROMED RES LAB,AIRCREW HLTH & PERFORMANCE DIV,VISUAL SCI BRANCH,ATTN MCMR-UAS-VS,POB 620577,FT RUCKER,AL 36362, USA. NR 16 TC 9 Z9 10 U1 0 U2 2 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD FEB PY 1996 VL 67 IS 2 BP 161 EP 164 PG 4 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA TT661 UT WOS:A1996TT66100012 PM 8834943 ER PT J AU May, CH Sing, HC Cephus, R Vogel, S Shaya, EK Wagner, HN AF May, CH Sing, HC Cephus, R Vogel, S Shaya, EK Wagner, HN TI A new method of monitoring motor activity in baboons SO BEHAVIOR RESEARCH METHODS INSTRUMENTS & COMPUTERS LA English DT Article ID STRIATAL DOPAMINE; MPTP MONKEYS; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; PRIMATE; MARMOSETS; RECOVERY; DISEASE; LESIONS; DESIGN AB Movement activity of a normal baboon and of a baboon with induced Parkinsonism by unilateral administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrine (MPTP) was recorded by the Waiter Reed Activity Monitor (or actigraph). Mean activity in the lesioned baboon was 41% less than that of the nonlesioned baboon measured over a 14-day period. In addition, the daily maximum activity value was significantly less in the MPTP-treated baboon. Moreover, resting and sleeping periods were 30% greater in the lesioned animal. The akinesia and resting and sleeping periods were displayed by the lesioned baboon throughout the day, whereas the control baboon showed them only at night. The data representing summarized movement activity are in accordance with observations of bradykinesia, hypokinesia, and akinesia of the MPTP-treated baboon. The actigraph was well tolerated by the animal because its small size and weight made it largely unobtrusive. We suggest that the actigraph is an appropriate device for measuring motor activity in nonhuman primates. C1 WALTER REED ARMY INST RES,WASHINGTON,DC. JOHNS HOPKINS UNIV,SCH MED,BALTIMORE,MD. JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,BALTIMORE,MD. RP May, CH (reprint author), HUMBOLDT UNIV BERLIN,BEREICH MED CHARITE,DEPT NEUROSURG,SCHUMANNSTR 20-21,D-10117 BERLIN,GERMANY. NR 15 TC 4 Z9 4 U1 0 U2 0 PU PSYCHONOMIC SOC INC PI AUSTIN PA 1710 FORTVIEW RD, AUSTIN, TX 78704 SN 0743-3808 J9 BEHAV RES METH INSTR JI Behav. Res. Methods Instr. Comput. PD FEB PY 1996 VL 28 IS 1 BP 23 EP 26 DI 10.3758/BF03203632 PG 4 WC Psychology, Mathematical; Psychology, Experimental SC Psychology GA TW726 UT WOS:A1996TW72600003 ER PT J AU Chavez, MD Shrader, BE Zahwa, HS MacDonald, VW AF Chavez, MD Shrader, BE Zahwa, HS MacDonald, VW TI Heme stability of partially oxidized hemoglobins. SO BIOPHYSICAL JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,BLOOD RES DETACHMENT,WASHINGTON,DC 20307. NR 2 TC 0 Z9 0 U1 0 U2 0 PU BIOPHYSICAL SOCIETY PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0006-3495 J9 BIOPHYS J JI Biophys. J. PD FEB PY 1996 VL 70 IS 2 BP MP376 EP MP376 PN 2 PG 1 WC Biophysics SC Biophysics GA TZ682 UT WOS:A1996TZ68201261 ER PT J AU Yakimov, MM Fredrickson, HL Timmis, KN AF Yakimov, MM Fredrickson, HL Timmis, KN TI Effect of heterogeneity of hydrophobic moieties on surface activity of lichenysin A, a lipopeptide biosurfactant from Bacillus licheniformis BAS50 SO BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY LA English DT Article ID BETA-AMINO ACIDS; STRUCTURAL-ANALYSIS; FATTY-ACIDS; SUBTILIS; BIOSYNTHESIS; BACILLUS-LICHENIFORMIS-86; REMOVAL; ITURIN; OIL AB Lichenysin A, a surface-active lipopeptide produced by Bacillus licheniformis, strain BAS50, contains long-chain beta-hydroxy fatty acids. Regulation of the synthesis of fatty acids and beta-hydroxy fatty acids was studied by modifying the culture medium. Addition of branched-chain alpha-amino acids to the medium caused similar changes to both cellular fatty acid and to beta-hydroxy fatty acid composition in the lipophilic part of lichenysin A. Production of lichenysin A was enhanced about two- and four-fold by addition of L-glutamic acid and L-asparagine respectively, It is suggested that these amino acids may be involved in the control of lipopeptide formation. Elucidation of the structure-function relationship of surface-active lipopeptides by analysis of the activities of structurally characterized compounds is discussed. Fractions of lichenysin A with branched beta-hydroxy acids in the lipid tail demonstrated lower surface-tension activity than the fractions of lichenysin A having straight beta-hydroxy acids. The presence of a lichenysin A fraction with beta-hydroxymyristic [(C-14)(n)] acid residues appears to have an important influence on the surface activity of a mixture of lichenysins A. C1 USAGE,WATERWAYS EXPT STN,ENVIRONM PROC & EFFECTS DIV,VICKSBURG,MS. RP Yakimov, MM (reprint author), GBF,NATL RES CTR BIOTECHNOL,DIV MICROBIOL,MASCHERODER WEG 1,D-38124 BRAUNSCHWEIG,GERMANY. OI Yakimov, Michail/0000-0003-1418-363X NR 26 TC 55 Z9 56 U1 0 U2 7 PU PORTLAND PRESS PI LONDON PA 59 PORTLAND PLACE, LONDON, ENGLAND W1N 3AJ SN 0885-4513 J9 BIOTECHNOL APPL BIOC JI Biotechnol. Appl. Biochem. PD FEB PY 1996 VL 23 BP 13 EP 18 PN 1 PG 6 WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology GA TV586 UT WOS:A1996TV58600004 PM 8867891 ER PT J AU Emery, VL Dillon, TM AF Emery, VL Dillon, TM TI Chronic toxicity of phenanthrene to the marine polychaete worm, Nereis (Neanthes) arenaceodentata SO BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article ID MYTILUS-EDULIS; RESPONSES; SEDIMENT; EXPOSURE; OIL RP Emery, VL (reprint author), USAE,WATERWAYS EXPT STN,ENVIRONM LAB,VICKSBURG,MS 39180, USA. NR 16 TC 9 Z9 9 U1 1 U2 3 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0007-4861 J9 B ENVIRON CONTAM TOX JI Bull. Environ. Contam. Toxicol. PD FEB PY 1996 VL 56 IS 2 BP 265 EP 270 PG 6 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA TM939 UT WOS:A1996TM93900015 PM 8720099 ER PT J AU Barillo, DJ McManus, AT Cioffi, WG McManus, WF Kim, SH Pruitt, BA AF Barillo, DJ McManus, AT Cioffi, WG McManus, WF Kim, SH Pruitt, BA TI Aeromonas bacteraemia in burn patients SO BURNS LA English DT Article ID WOUND-INFECTION; HYDROPHILA INFECTION; MEDICINAL LEECHES; BACTEREMIA; SKIN; CELLULITIS AB Human aeromonas infection is uncommon and is usually associated with immunosuppression, chronic disease or trauma in an aquatic setting. Burn injury may induce a state of immunosuppression, making the thermally injured patient a suitable host for aeromonas infection. We reviewed the experience of one burn centre with this pathogen. Retrospective examination of blood culture results from 8151 patients admitted between 1959 and 1994 disclosed eight patients with clinically relevant Aeromonas hydrophilia bacteraemia. Five were burned outside the USA. Aquatic exposure was known or suspected in only three cases. Five of the eight patients died. RP Barillo, DJ (reprint author), USA,INST SURG RES,FT SAM HOUSTON,TX 78234, USA. NR 33 TC 24 Z9 27 U1 1 U2 1 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0305-4179 J9 BURNS JI Burns PD FEB PY 1996 VL 22 IS 1 BP 48 EP 52 DI 10.1016/0305-4179(95)00075-5 PG 5 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA TM445 UT WOS:A1996TM44500011 PM 8719317 ER PT J AU Morrison, EE Ebeling, RM AF Morrison, EE Ebeling, RM TI Limit equilibrium computation passive earth pressure: Reply SO CANADIAN GEOTECHNICAL JOURNAL LA English DT Editorial Material RP Morrison, EE (reprint author), USA,ENGINEER WATERWAYS EXPT STN,CEWES,IM,DS,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A 0R6, CANADA SN 0008-3674 J9 CAN GEOTECH J JI Can. Geotech. J. PD FEB PY 1996 VL 33 IS 1 BP 203 EP 203 DI 10.1139/t96-039 PG 1 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA UC527 UT WOS:A1996UC52700020 ER PT J AU Mather, B AF Mather, B TI Membrane curing of concrete: Moisture loss - Discussion SO CEMENT AND CONCRETE RESEARCH LA English DT Editorial Material RP Mather, B (reprint author), USA,ENGINEER WATERWAYS EXPT STN,STRUCT LAB,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 10 TC 0 Z9 0 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0008-8846 J9 CEMENT CONCRETE RES JI Cem. Concr. Res. PD FEB PY 1996 VL 26 IS 2 BP 337 EP 340 DI 10.1016/0008-8846(95)00208-1 PG 4 WC Construction & Building Technology; Materials Science, Multidisciplinary SC Construction & Building Technology; Materials Science GA UD754 UT WOS:A1996UD75400020 ER PT J AU Laird, JR Carter, AJ Kufs, WM Hoopes, TG Farb, A Nott, SH Fischell, RE Fischell, DR Virmani, R Fischell, TA AF Laird, JR Carter, AJ Kufs, WM Hoopes, TG Farb, A Nott, SH Fischell, RE Fischell, DR Virmani, R Fischell, TA TI Inhibition of neointimal proliferation with low-dose irradiation from a beta-particle-emitting stent SO CIRCULATION LA English DT Article DE restenosis; beta-particle; radiation; stents ID LUMINAL CORONARY ANGIOPLASTY; ARTERY INJURY; RESTENOSIS; MODEL; HYPERPLASIA; EXPERIENCE; RADIATION; KINETICS; KELOIDS AB Background Restenosis after successful percutaneous trans luminal coronary angioplasty is the major factor limiting the long-term effectiveness of this procedure. Neointimal proliferation in response to arterial injury is an important contributor to restenosis. The use of radiation for the treatment of malignant and benign proliferative conditions has been well established. External beam irradiation and endovascular irradiation by use of an after-loading technique have been shown to inhibit neointimal proliferation in experimental models of restenosis. The objective of this study was to investigate whether low-dose irradiation from a beta-particle-emitting stent would inhibit neointimal proliferation after placement in porcine iliac arteries. Methods and Results Fourteen titanium-mesh stents were implanted in the iliac arteries of nine NIH miniature swine. There were seven beta-particle-emitting radioisotope stents (P-32, activity level 0.14 mu Ci) and seven control stents (P-31, nonradioactive). Treatment effect was assessed by angiography and histomorphological examination of the stented iliac segments 28 days after implantation. There was a significant reduction in neointimal area (1.76+/-0.37 mm(2) versus 2.81+/-1.22 mm(2), P=.05) and percent area stenosis (24.6+/-2.9% versus 36.0+/-10.7%, P=.02) within the beta-particle-emitting stents compared with the control stents. Neointimal thickness, which was assessed at each wire site, was also significantly less within the treatment stents (0.26+/-0.04 mm versus 0.38+/-0.10 mm, P=.012). Scanning electron microscopy was performed on sections from four stents. This demonstrated endothelialization of both the treatment and control stents. There was no excess inflammatory reaction or fibrosis in the media, adventitia, or perivascular space of vessels treated with the beta-particle-emitting stent compared with control vessels. At 28 days, there was no difference in smooth muscle cell proliferation as measured by the proliferating cell nuclear antigen index. Conclusions A local, continuous source of low-dose endovascular irradiation via a beta-particle-emitting stent inhibits neointimal formation in porcine arteries. This low dose of local irradiation did not prevent endothelialization of the stents. This novel technique offers promise for the prevention of restenosis and warrants further investigation. C1 ARMED FORCES INST PATHOL,WASHINGTON,DC 20306. BOSTON SCI CORP,WATERTOWN,MA. ISOSTENT INC,DAYTON,MD. VANDERBILT UNIV,SCH MED,DIV CARDIOL,NASHVILLE,TN 37212. RP Laird, JR (reprint author), WALTER REED ARMY MED CTR,SERV CARDIOL,WASHINGTON,DC 20307, USA. NR 40 TC 139 Z9 144 U1 0 U2 2 PU AMER HEART ASSOC PI DALLAS PA 7272 GREENVILLE AVENUE, DALLAS, TX 75231-4596 SN 0009-7322 J9 CIRCULATION JI Circulation PD FEB 1 PY 1996 VL 93 IS 3 BP 529 EP 536 PG 8 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA TR330 UT WOS:A1996TR33000020 PM 8565172 ER PT J AU Li, OG Barcus, M Wellington, S Brueckner, R AF Li, OG Barcus, M Wellington, S Brueckner, R TI Plasma protein and red blood cell binding of WR238605, a candidate antimalarial drug SO CLINICAL PHARMACOLOGY & THERAPEUTICS LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0009-9236 J9 CLIN PHARMACOL THER JI Clin. Pharmacol. Ther. PD FEB PY 1996 VL 59 IS 2 BP PI53 EP PI53 PG 1 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA TX001 UT WOS:A1996TX00100053 ER PT J AU Blair, JRS Mutchler, D vanLent, M AF Blair, JRS Mutchler, D vanLent, M TI Perfect recall and pruning in games with imperfect information SO COMPUTATIONAL INTELLIGENCE LA English DT Article DE game tree; imperfect information; perfect recall; heuristic search; pruning; alpha-beta; IMP-minimax; IMP-alpha-beta; NP-hard; NP-complete ID CONSPIRACY NUMBERS; CHAMPIONSHIP; SEARCH AB Games with imperfect information are an interesting and important class of games. They include most card games (e.g., bridge and poker) as well as many economic and political models. Here we investigate algorithms for finding the simplest form of a solution (a pure-strategy equilibrium point) to imperfect information games expressed in their extensive (game tree) form. We introduce to the artificial intelligence community a classic algorithm, due to Wilson, that solves one-player games with perfect recall. Wilson's algorithm, which we call IMP-minimax, runs in time linear in the size of the game-tree searched. In contrast to Wilson's result, Koller and Meggido have shown that finding a pure-strategy equilibrium point in one-player games without perfect recall is NP-hard. Here, we provide another contrast to Wilson's result-we show that in games with perfect recall but more than one player, finding a pure-strategy equilibrium point, given that such an equilibrium point exists, is NP-hard. Our second contribution is to present a pruning technique for Wilson's IMP-minimax algorithm to make the latter more tractable. We call this new algorithm IMP-alpha-beta. We provide a theoretical framework (model) and analyze IMP-alpha-beta in that model. IMP-alpha-beta is of direct value for one-player, perfect-recall games. It also has strong potential for other imperfect information games, as it is a natural (but as yet untested) heuristic in those cases. C1 ROSE HULMAN INST TECHNOL,DEPT COMP SCI,TERRE HAUTE,IN 47803. UNIV MICHIGAN,DEPT ELECT ENGN & COMP SCI,ANN ARBOR,MI 48109. RP Blair, JRS (reprint author), US MIL ACAD,DEPT ELECT ENGN & COMP SCI,W POINT,NY 10996, USA. NR 40 TC 5 Z9 5 U1 2 U2 2 PU BLACKWELL PUBLISHERS PI CAMBRIDGE PA 350 MAIN STREET, STE 6, CAMBRIDGE, MA 02148-5023 SN 0824-7935 J9 COMPUT INTELL JI Comput. Intell. PD FEB PY 1996 VL 12 IS 1 BP 131 EP 154 DI 10.1111/j.1467-8640.1996.tb00256.x PG 24 WC Computer Science, Artificial Intelligence SC Computer Science GA UC853 UT WOS:A1996UC85300008 ER PT J AU Bellamy, R Safar, P Tisherman, SA Basford, R Bruttig, SP Capone, A Dubick, MA Ernster, L Hattler, BG Hochachka, P Klain, M Kochanek, PM Kofke, WA Lancaster, JR McGowan, FX Oeltgen, PR Severinghaus, JW Taylor, MJ Zar, H AF Bellamy, R Safar, P Tisherman, SA Basford, R Bruttig, SP Capone, A Dubick, MA Ernster, L Hattler, BG Hochachka, P Klain, M Kochanek, PM Kofke, WA Lancaster, JR McGowan, FX Oeltgen, PR Severinghaus, JW Taylor, MJ Zar, H TI Suspended animation for delayed resuscitation SO CRITICAL CARE MEDICINE LA English DT Article; Proceedings Paper CT International Resuscitation Research Conference (IRRC 94) CY MAY 07-09, 1994 CL PITTSBURGH, PA DE cerebral anoxia; cardiopulmonary resuscitation; hypothermia; ischemia; exsanguination; suspended animation; cardiac arrest; preservation; hibernation; cardiopulmonary bypass ID AUTOPERFUSION MULTIORGAN PREPARATION; HYPOTHERMIC CIRCULATORY ARREST; HIBERNATION INDUCTION TRIGGER; NITRIC-OXIDE; REPERFUSION INJURY; HEMORRHAGIC-SHOCK; PARTIAL EPILEPSY; CARDIAC-ARREST; MAJOR ORGANS; ISCHEMIA AB Suspended animation is defined as the therapeutic induction of a state of tolerance to temporary complete systemic ischemia, i.e., protection-preservation of the whole organism during prolonged circulatory arrest (greater than or equal to 1 hr), followed by resuscitation to survival without brain damage. The objectives of suspended animation include: a) helping to save victims of temporarily uncontrollable (internal) traumatic (e.g., combat casualties) or nontraumatic (e.g., ruptured aortic aneurysm) exsanguination, without severe brain trauma, by enabling evacuation and resuscitative surgery during circulatory arrest, followed by delayed resuscitation; b) helping to save some nontraumatic cases of sudden death, seemingly unresuscitable before definitive repair; and c) enabling selected (elective) surgical procedures to be performed which are only feasible during a state of no blood flow. In the discussion session, investigators with suspended animation relevant research interests brainstorm on present knowledge, future research potentials, and the advisability of a major research effort concerning this subject. The following topics are addressed: the epidemiologic facts of sudden death in combat casualties, which require a totally new resuscitative approach; the limits and potentials of reanimation research; complete reversibility of circulatory arrest of 1 hr in dogs under profound hypothermia (<10 degrees C), induced and reversed by portable cardiopulmonary bypass; the need for a still elusive pharmacologic or chemical induction of suspended animation in the field; asanguinous profound hypothermic low-flow with cardiopulmonary bypass; electric anesthesia; opiate therapy; lessons learned from hypoxia tolerant vertebrate animals, hibernators, and freeze tolerant animals (cryobiology); myocardial preservation during open heart surgery; organ preservation for transplantation; and reperfusion reoxygenation injury in vital organs, including the roles of nitric oxide and free radicals; and how cells (particularly cerebral neurons) die after transient prolonged ischemia and reperfusion. The majority of authors believe that seeking a breakthrough in suspended animation is not utopian, that ongoing communication between relevant research groups is indicated, and that a coordinated multicenter research effort, basic and applied, on suspended animation is justified. C1 UNIV PITTSBURGH,SAFAR CTR RESUSCITAT RES,PITTSBURGH,PA 15260. PONTCTOC CANYON ESTATES,TUCSON,AZ 85718. USA,MED RES & MAT COMMAND,SGRD PLB,FREDERICK,MD 21702. SGRD USMT,HOUSTON,TX 78234. UNIV STOCKHOLM,ARRHENIUS LAB,DEPT BIOCHEM,S-10691 STOCKHOLM,SWEDEN. UNIV PITTSBURGH,MED CTR,DEPT SURG,PITTSBURGH,PA 15213. UNIV BRITISH COLUMBIA,DEPT ZOOL & SPORTS MED,VANCOUVER,BC V5Z 1M9,CANADA. UNIV PITTSBURGH,MED CTR,DEPT ANESTHESIOL & NEUROSURG,PITTSBURGH,PA 15260. LOUISIANA STATE UNIV,MED CTR,NEW ORLEANS,LA 70112. UNIV PITTSBURGH,CHILDRENS HOSP PITTSBURGH,DEPT ANESTHESIOL,CCM,PITTSBURGH,PA 15213. VET ADM MED CTR,LEXINGTON,KY 40511. UNIV CALIF SAN FRANCISCO,DEPT ANESTHESIOL,SAN FRANCISCO,CA 94143. ALLEGHENY GEN HOSP,PITTSBURGH,PA 15212. RP Bellamy, R (reprint author), WALTER REED ARMY MED CTR,BORDEN INST,BLDG 11,ROOM 1-117,6825 16TH ST NW,WASHINGTON,DC 20307, USA. RI Kochanek, Patrick/D-2371-2015 OI Kochanek, Patrick/0000-0002-2627-913X NR 123 TC 60 Z9 61 U1 0 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD FEB PY 1996 VL 24 IS 2 SU S BP S24 EP S47 PG 24 WC Critical Care Medicine SC General & Internal Medicine GA TW260 UT WOS:A1996TW26000004 PM 8608704 ER PT J AU Shoemaker, WC Peitzman, AB Bellamy, R Bellomo, R Bruttig, SP Capone, A Dubick, M Kramer, GC McKenzie, JE Pepe, PE Safar, P Schlichtig, R Severinghaus, JW Tisherman, SA Wiklund, L AF Shoemaker, WC Peitzman, AB Bellamy, R Bellomo, R Bruttig, SP Capone, A Dubick, M Kramer, GC McKenzie, JE Pepe, PE Safar, P Schlichtig, R Severinghaus, JW Tisherman, SA Wiklund, L TI Resuscitation from severe hemorrhage SO CRITICAL CARE MEDICINE LA English DT Article; Proceedings Paper CT International Resuscitation Research Conference (IRRC 94) CY MAY 07-09, 1994 CL PITTSBURGH, PA DE resuscitation; hypovolemic shock; hemorrhagic shock; uncontrolled hemorrhagic shock; monitoring, physiologic; fluid therapy ID HYPERTONIC SALINE-DEXTRAN; TRAUMA PATIENTS; AWAKE RATS; SHOCK; VOLUME; MODEL; SURVIVAL; OXYGEN; MUSCLE; SWINE AB The potential to be successfully resuscitated from severe traumatic hemorrhagic shock is not only limited by the ''golden 1 hr,'' but also by the ''brass (or platinum) 10 mins'' for combat casualties and civilian trauma victims with traumatic exsanguination. One research challenge is io determine how best to prevent cardiac arrest during severe hemorrhage, before control of bleeding is possible. Another research challenge is to determine the critical limits of, and optimal treatments for, protracted hemorrhagic hypotension, in order to prevent ''delayed'' multiple organ failure after hemostasis and all-out resuscitation. Animal research is shifting from the use of unrealistic, pressure-controlled, hemorrhagic shock models and partially realistic, volume-controlled hemorrhagic shock models to more realistic, uncontrolled hemorrhagic shock outcome models. Animal outcome models of combined trauma and shock are needed; a challenge is to find a humane and clinically realistic longterm method for analgesia that does not interfere with cardiovascular responses. Clinical potentials in need of research are shifting from normotensive to hypotensive (limited) fluid resuscitation with plasma substitutes. Topics included optimal temperature, fluid composition, analgesia, and pharmacotherapy. Hypotensive fluid resuscitation in uncontrolled hemorrhagic shock with the addition of moderate resuscitative (28 degrees to 32 degrees C) hypothermia looks promising in the laboratory. Regarding the composition of the resuscitation fluid, despite encouraging results with new preparations of stroma-free hemoglobin and hypertonic salt solutions with colloid, searches for the optimal combination of oxygen carrying blood substitute, colloid, and electrolyte solution for limited fluid resuscitation with the smallest volume should continue. For titrating treatment of shock, blood lactate concentrations are of questionable value, although metabolic acidemia seems helpful for prognostication. Development of devices for early noninvasive monitoring of multiple parameters in the field is indicated. Molecular research applies more to protracted hypovolemic shock followed by the systemic inflammatory response syndrome or septic shock, which were not the major topics of this discussion. C1 UNIV PITTSBURGH,MED CTR,DEPT SURG,PITTSBURGH,PA 15213. WALTER REED ARMY MED CTR,BORDEN INST,WASHINGTON,DC 20307. UNIV PITTSBURGH,MED CTR,DEPT CRIT CARE MED,PITTSBURGH,PA 15261. USA,MED RES & MAT COMMAND,SGRD PLB,FREDERICK,MD 21702. SGRD,USMT,HOUSTON,TX. UNIV TEXAS,MED BRANCH,GALVESTON,TX 77555. UNIFORMED SERV UNIV HLTH SCI,DEPT PHYSIOL,BETHESDA,MD 20814. EMERGENCY MED SERV CITY HOUSTON,HOUSTON,TX 77002. UNIV PITTSBURGH,SAFAR CTR RESUSCITAT RES,PITTSBURGH,PA 15260. UNIV PITTSBURGH,MED CTR,DEPT ANESTHESIOL,CCM,PITTSBURGH,PA 15240. UNIV CALIF SAN FRANCISCO,DEPT ANESTHESIOL,SAN FRANCISCO,CA 94143. UNIV UPPSALA HOSP,DEPT ANESTHESIOL,S-75014 UPPSALA,SWEDEN. RP Shoemaker, WC (reprint author), CHARLES R DREW UNIV MED & SCI,KING DREW MED CTR,DEPT EMERGENCY MED,1621 E 120TH ST,MP 34,LOS ANGELES,CA 90059, USA. NR 70 TC 107 Z9 116 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD FEB PY 1996 VL 24 IS 2 SU S BP S12 EP S23 PG 12 WC Critical Care Medicine SC General & Internal Medicine GA TW260 UT WOS:A1996TW26000003 PM 8608703 ER PT J AU Thompson, WL Bellamy, R Cummins, RO Delooz, HH Dick, W Kochanek, PM Ornato, JP Ricci, EM Weil, MH Winter, PM AF Thompson, WL Bellamy, R Cummins, RO Delooz, HH Dick, W Kochanek, PM Ornato, JP Ricci, EM Weil, MH Winter, PM TI Funding resuscitation research SO CRITICAL CARE MEDICINE LA English DT Article; Proceedings Paper CT International Resuscitation Research Conference (IRRC 94) CY MAY 07-09, 1994 CL PITTSBURGH, PA DE managed care programs; research support; trauma; cardiopulmonary resuscitation; industry; government; nongovernmental agencies; cerebral resuscitation; foundations; American Heart Association AB The present trend in managed care has meant downsizing expectations concerning the availability of support for resuscitation research. This trend applies to funding possibilities from industry, governmental agencies, and nongovernmental agencies (Table 1). There will be increasing barriers to making innovations. Truth, science, and good patient care alone will not make potential donors give grants. Investigators must also understand the potential donors' expectations and be persuasive. ''Delight your donor. Industries' concerns include intellectual property rights and publications. The National Institutes of Health, recently favoring molecular biology over lifesaving therapies or integrated physiologic research, is an anomaly. The current peer review system propagates itself without having advocates for resuscitation research. This system has become a self-fulfilling prophecy. The American Heart Association is only recently, after 30 yrs of educational activities concerning cardiopulmonary resuscitation, considering putting some basic research money into resuscitation research, in university hospitals, where clinical departments have made significant contributions to innovative, clinically relevant life support research, funded with incomes from patient care, the sky is beginning to fall. Resuscitation researchers need persuasive advocates with clout and hard data to convince funding agencies to give support to multilevel research and development in areas of pathophysiology and reversibility of terminal states and clinical death-to give these topics a higher priority than is currently available. C1 WALTER REED ARMY MED CTR,BORDEN INST,WASHINGTON,DC 20307. UNIV WASHINGTON,MED CTR,SEATTLE,WA 98195. ACAD ZIEKENHUIS,DEPT EMERGENCY MED,B-3000 LOUVAIN,BELGIUM. UNIV MAINZ,W-6500 MAINZ,GERMANY. UNIV PITTSBURGH,SAFAR CTR RESUSCITAT RES,PITTSBURGH,PA 15260. VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,EMS,RICHMOND,VA 23298. UNIV PITTSBURGH,HLTH SERV ADM,PITTSBURGH,PA 15260. INST CRIT CARE MED,PALM SPRINGS,CA 92262. UNIV PITTSBURGH,DEPT ANESTHESIOL CRIT CARE MED,PITTSBURGH,PA 15261. RI Kochanek, Patrick/D-2371-2015 OI Kochanek, Patrick/0000-0002-2627-913X NR 0 TC 1 Z9 1 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD FEB PY 1996 VL 24 IS 2 SU S BP S90 EP S94 PG 5 WC Critical Care Medicine SC General & Internal Medicine GA TW260 UT WOS:A1996TW26000009 PM 8608710 ER PT J AU Coots, NV McCoy, CE Gehlbach, DL Becker, LE AF Coots, NV McCoy, CE Gehlbach, DL Becker, LE TI A neutrophilic drug reaction to Clomid(R) SO CUTIS LA English DT Article AB A 33-year-old woman treated for infertility with multiple courses of clomiphene citrate (Clomid(R)) presented with the complaint of a rash with every course of the medication. Examination revealed petechiae and palpable purpura on her lower extremities which, histologically, were found to be consistent with a neutrophilic drug reaction. The clinical course of this unusual presentation, as well as a brief review of the neutrophilic dermatoses, are provided. C1 BROOKE ARMY MED CTR,DEPT OBSTET & GYNECOL,FT SAM HOUSTON,TX 78234. F EDWARD HERBERT SCH MED,DEPT OBSTET & GYNECOL,BETHESDA,MD. RP Coots, NV (reprint author), BROOKE ARMY MED CTR,DERMATOL CLIN,DERMATOL SECT,FT SAM HOUSTON,TX 78234, USA. NR 3 TC 1 Z9 1 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0011-4162 J9 CUTIS JI Cutis PD FEB PY 1996 VL 57 IS 2 BP 91 EP 93 PG 3 WC Dermatology SC Dermatology GA TX543 UT WOS:A1996TX54300006 PM 8646861 ER PT J AU Boyer, JD Cobb, MW Sperling, LC Rushin, JM AF Boyer, JD Cobb, MW Sperling, LC Rushin, JM TI Loose anagen hair syndrome mimicking the uncombable hair syndrome SO CUTIS LA English DT Article AB A 7-year-old female presented with messy, difficult to manage scalp hair and mild, diffuse alopecia. Hair pull specimens, diagnostic for loose anagen hair syndrome, also showed hair shaft abnormalities described in the uncombable hair syndrome. We suggest that dysmorphic hair shafts observed on our patient account for her clinically unmanageable hair. Pertinent clinical, pathologic, and diagnostic features of both syndromes are reviewed. C1 WALTER REED ARMY MED CTR, WASHINGTON, DC 20307 USA. RP Boyer, JD (reprint author), NATL NAVAL MED CTR, DEPT DERMATOL, BETHESDA, MD 20889 USA. NR 6 TC 15 Z9 15 U1 0 U2 1 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0011-4162 J9 CUTIS JI Cutis PD FEB PY 1996 VL 57 IS 2 BP 111 EP 112 PG 2 WC Dermatology SC Dermatology GA TX543 UT WOS:A1996TX54300011 PM 8646855 ER PT J AU Quebedeaux, TL Lavery, LA Lavery, DC AF Quebedeaux, TL Lavery, LA Lavery, DC TI The development of foot deformities and ulcers after great toe amputation in diabetes SO DIABETES CARE LA English DT Article AB OBJECTIVE - Our aim was to compare the prevalence and severity of foot deformities and the development of ulcerations in patients after a great toe amputations. RESEARCH DESIGN AND METHODS - We evaluated the presence of deformities of the toes and metatarsophalangeal joints (MTPJs) in patients with a great toe amputation who had an intact unamputated contralateral foot. The contralateral foot served as the patient's own control. We used a binomial test for paired data to compare the presence of deformity and ulcer formation and Fisher's exact test to compare joint flexibility in toes and MTPJs with foot deformities. RESULTS - There were more deformities of the second (P = 0.012) and third (P = 0.002) toes and lesser MTPJs (P < 0.05) and more rigid deformities of the second (P = 0.002) and third (P = 0.016) toes and second MTPJs (P = 0.035) in feet with great toe amputations. New ulcers were more common in feet that had an amputation (P = 0.002). CONCLUSIONS - We concluded that amputation of the great toe contributes to the development of deformities of the second and third toes and lesser MTPJs and new ulcer formation in patients with diabetes. When deformities were present, the second and third toes and second MTPJ were more severe in feet with a great toe amputation. C1 MEXICAN AMER MED TREATMENT EFFECTIVENESS RES CTR,SAN ANTONIO,TX. US MIL ACAD,DEPT MATH SCI,W POINT,NY 10996. RP Quebedeaux, TL (reprint author), UNIV TEXAS,HLTH SCI CTR,DEPT ORTHOPAED,7703 FLOYD CURL DR,SAN ANTONIO,TX 78284, USA. NR 9 TC 40 Z9 40 U1 0 U2 1 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1660 DUKE ST, ALEXANDRIA, VA 22314 SN 0149-5992 J9 DIABETES CARE JI Diabetes Care PD FEB PY 1996 VL 19 IS 2 BP 165 EP 167 DI 10.2337/diacare.19.2.165 PG 3 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA TR892 UT WOS:A1996TR89200012 PM 8718439 ER PT J AU Vendier, O Jokerst, NM Leavitt, RP AF Vendier, O Jokerst, NM Leavitt, RP TI Thin-film inverted MSM photodetectors SO IEEE PHOTONICS TECHNOLOGY LETTERS LA English DT Article ID INGAAS AB To improve the external quantum efficiency and maintain the high speed of metal-semiconductor-metal (MSM) photodetectors, a thin film inverted MSM (I-MSM), which is separated from the growth substrate, has fingers on the bottom of the device, and is bonded to a silicon host substrate, is reported for the first time. This device optimizes the tradeoff between speed and responsivity, demonstrating the improvement in responsivity that can be achieved using an I-MSM. The photodetector time domain response at lambda = 1.3 mu m is 50 ps FWHM, with a 34 ps rise time and a 85 ps fall time. C1 USA,RES LABS,DIV PHYS,ADELPHI,MD 20783. RP Vendier, O (reprint author), GEORGIA INST TECHNOL,SCH ELECT & COMP ENGN,MICROELECTR RES CTR,MFG RES CTR,ATLANTA,GA 30332, USA. NR 17 TC 32 Z9 32 U1 1 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 1041-1135 J9 IEEE PHOTONIC TECH L JI IEEE Photonics Technol. Lett. PD FEB PY 1996 VL 8 IS 2 BP 266 EP 268 DI 10.1109/68.484262 PG 3 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA TU609 UT WOS:A1996TU60900032 ER PT J AU Vitebskiy, S Sturgess, K Carin, L AF Vitebskiy, S Sturgess, K Carin, L TI Short-pulse plane-wave scattering from buried perfectly conducting bodies of revolution SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Article ID ELECTROMAGNETIC SCATTERING; TRANSIENT-RESPONSE; EXTRACTING POLES; RADIATION; SURFACES; SYSTEM; RADAR; BODY AB The method of moments is used to analyze short-pulse plane-wave scattering from perfectly conducting bodies of revolution buried in a lossy, dispersive half space. The analysis is performed in the frequency domain, with the time-domain fields synthesized via Fourier transform. To make this analysis efficient, the method of complex images is used to compute the frequency-dependent components of the half-space dyadic Green's function. Results are presented for short-pulse scattering from buried spheres and cylinders, using measured frequency-dependent soil parameters (permittivity and conductivity). C1 USA,RES LAB,SENSORS DIRECTORATE,ADELPHI,MD 20783. RP Vitebskiy, S (reprint author), DUKE UNIV,DEPT ELECT ENGN,DURHAM,NC 27708, USA. NR 37 TC 64 Z9 70 U1 1 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-926X J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD FEB PY 1996 VL 44 IS 2 BP 143 EP 151 DI 10.1109/8.481640 PG 9 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA TV808 UT WOS:A1996TV80800002 ER PT J AU Zheng, JP Cygan, PJ Jow, TR AF Zheng, JP Cygan, PJ Jow, TR TI Investigation of dielectric properties of polymer laminates with polyvinylidene fluoride SO IEEE TRANSACTIONS ON DIELECTRICS AND ELECTRICAL INSULATION LA English DT Article ID BREAKDOWN; POLYETHYLENE AB The breakdown field strength of polymer laminates consisting of polymer base films coated with a thin layer of polyvinylidene fluoride (PVDF) was investigated. The spin coating technique was used to make a layer of PVDF film. It was found that the de breakdown field strength could be increased by as much as 18% by applying a very thin coating. The breakdown field strength was insensitive to the thickness of the polymer base films and the thickness of the PVDF coating within the thickness range used in the experiment. The effect of the coating on the permittivity and dissipation factor of polymer films over a wide frequency range was determined. Possible mechanisms for the enhancement of breakdown field strength have been discussed. RP Zheng, JP (reprint author), USA, RES LAB, PHYS SCI DIRECTORATE, FT MONMOUTH, NJ USA. NR 11 TC 4 Z9 4 U1 1 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 1070-9878 J9 IEEE T DIELECT EL IN JI IEEE Trns. Dielectr. Electr. Insul. PD FEB PY 1996 VL 3 IS 1 BP 144 EP 147 DI 10.1109/94.485527 PG 4 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA UB283 UT WOS:A1996UB28300018 ER PT J AU Woolard, DL Buot, FA Rhodes, DL Lu, XJ Perlman, BS AF Woolard, DL Buot, FA Rhodes, DL Lu, XJ Perlman, BS TI An assessment of potential nonlinear circuit models for the characterization of resonant tunneling diodes SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Article ID MAXIMUM OSCILLATION FREQUENCY; INTRINSIC BISTABILITY; STATE LIFETIME; DEVICES; SIMULATION; GHZ AB The intrinsically fast process of resonant tunneling through double barrier heterostructures along with the existence of negative differential resistance in the current-voltage characteristic of these structures has led to their implementation as sources for high frequency electromagnetic energy. While sources based upon resonant tunneling diodes (RTD's) have produced frequency of oscillations up to 712 GHz, only microwatt levels of performance has been achieved above 100 GHz, Since stability criteria play a critical role in determining the deliverable power of any oscillator, a physically accurate equivalent-circuit model for the RTD is extremely important for optimizing the dynamics of the device-cavity package, This study identifies a distinctly new equivalent circuit model for characterizing the modes of oscillation in RTD-based sources. Specifically, in order to exhibit the fundamental seif-oscillations and the overall IV characteristics (plateau structure and hysteresis) observed experimentally, an accurate circuit model of the RTD must incorporate; (i) a quantum-wed inductance which directly chokes the nonlinear conductance and, (ii) a nonlinear access resistance, associated with the accumulation of charge in the injection region of the double barriers, with a nonlocal dependence on the bias across the double barrier structure. C1 USN,RES LAB,WASHINGTON,DC 20375. RP Woolard, DL (reprint author), USA,RES LAB,PSD,FT MONMOUTH,NJ 07703, USA. NR 32 TC 7 Z9 8 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9383 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD FEB PY 1996 VL 43 IS 2 BP 332 EP 341 DI 10.1109/16.481736 PG 10 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA TU665 UT WOS:A1996TU66500020 ER PT J AU Solomond, JP AF Solomond, JP TI International high technology cooperation: Lessons learned SO IEEE TRANSACTIONS ON ENGINEERING MANAGEMENT LA English DT Article AB In February 1986, in response to the Nunn Amendment in the United States, a special Conference of National Armaments Directors (CNAD) examined possible ways to foster cooperative high technology research and development programs within the NATO Alliance. As a result, they established the Special Working Group on Ada Programming Support Environments (SWG APSE) to oversee the development of a multinational software development environment for developing real-time weapon systems in the Ada programming language. The Working Group also developed a requirements specification for a software development environment interface standard. The author describes the benefits and pitfalls of this joint software development, He also describes the lessons learned from such joint multinational development efforts, Further, the author describes the management issues that are unique to such an international collaborative effort and gives a frank assessment of the techniques that had helped and hindered the program's progress. RP Solomond, JP (reprint author), USA,MAT COMMAND HEADQUARTERS,ALEXANDRIA,VA 22333, USA. NR 9 TC 9 Z9 9 U1 1 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9391 J9 IEEE T ENG MANAGE JI IEEE Trans. Eng. Manage. PD FEB PY 1996 VL 43 IS 1 BP 69 EP 77 DI 10.1109/17.491270 PG 9 WC Business; Engineering, Industrial; Management SC Business & Economics; Engineering GA UG108 UT WOS:A1996UG10800010 ER PT J AU Haijar, SG AF Haijar, SG TI Iran and Iraq: The threat from the northern Gulf - Cordesman,AH SO INTERNATIONAL JOURNAL OF MIDDLE EAST STUDIES LA English DT Book Review RP Haijar, SG (reprint author), USA,DEPT NATL SECUR & STRATEGY,COLL WAR,CARLISLE,PA, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 40 WEST 20TH STREET, NEW YORK, NY 10011-4211 SN 0020-7438 J9 INT J MIDDLE E STUD JI Int. J. Middle East Stud. PD FEB PY 1996 VL 28 IS 1 BP 119 EP 121 PG 3 WC Area Studies SC Area Studies GA TV281 UT WOS:A1996TV28100013 ER PT J AU Davis, DF Fong, ML AF Davis, DF Fong, ML TI Measuring outcomes in psychiatry: An inpatient model SO JOINT COMMISSION JOURNAL ON QUALITY IMPROVEMENT LA English DT Article AB Background: This article describes a system for measuring outcomes recently implemented in the department of psychiatry of Baptist Memorial Hospital, a 78-bed inpatient and day treatment unit that represents one service line of a large, urban teaching hospital in Memphis. In June 1993 Baptist Hospital began a 15-month pilot test of PsychSentinel, a measurement tool developed by researchers in the Department of Community Medicine at the University of Connecticut. The hospital identified the following four primary goals for this pilot project: provide data for internal hospital program evaluation, provide data for external marketing in a managed care environment, satisfy requirements of the Joint Commission on Accreditation of Health Care Organizations, and generate studies that add to the literature in psychiatry and psychology. Description of measure: PsychSentinel is based on the standardized diagnostic criteria in the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV). The outcome measure assesses the change in the number of symptoms of psychopathology that occurs between admission and discharge from the hospital. Included in the nonproprietary system are risk adjustment factors, as well as access to a national reference database for comparative analysis purposes. Data collection can be done by trained ancillary staff members, with as much or as little direct physician involvement as desired. The system has proven to be both time effective and cost effective, and it provides important outcome information both at the program level and at the clinician level. Results: After the pilot test, the staff at Baptist Memorial Hospital determined that the system met all initial objectives identified and recently adopted the system as an ongoing measure of quality patient care in the department of psychiatry. C1 MEMPHIS UNIV,DEPT COUNSELING EDUC PSYCHOL & RES,MEMPHIS,TN 38152. RP Davis, DF (reprint author), TRIPLER ARMY MED CTR,MED SERV CORPS,HONOLULU,HI 96859, USA. NR 14 TC 10 Z9 10 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 1070-3241 J9 JOINT COMM J QUAL IM JI Jt. Comm. J. Qual. Improv. PD FEB PY 1996 VL 22 IS 2 BP 125 EP 133 PG 9 WC Health Policy & Services SC Health Care Sciences & Services GA TY105 UT WOS:A1996TY10500006 PM 8646301 ER PT J AU Robinson, CA AF Robinson, CA TI Sport nutritional knowledge of adolescents. SO JOURNAL OF ADOLESCENT HEALTH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 1054-139X J9 J ADOLESCENT HEALTH JI J. Adolesc. Health PD FEB PY 1996 VL 18 IS 2 BP 139 EP 139 PG 1 WC Psychology, Developmental; Public, Environmental & Occupational Health; Pediatrics SC Psychology; Public, Environmental & Occupational Health; Pediatrics GA TX086 UT WOS:A1996TX08600056 ER PT J AU Lee, PCY Yang, JS Yu, JD Ballato, A AF Lee, PCY Yang, JS Yu, JD Ballato, A TI Stress sensitivity of electromagnetic resonances in circular dielectric disks SO JOURNAL OF APPLIED PHYSICS LA English DT Article AB A formula for predicting the stress effect on the electromagnetic resonances of dielectric resonators is obtained by applying a perturbation method to the three-dimensional Maxwell's equations in which the dielectric permittivity tensor is perturbed by the applied stress (or strain) field through the piezo-optic effect. The dielectric resonator, which is surrounded by infinite free space, can be isotropic or anisotropic and of arbitrary shape. By using previously obtained two-dimensional closed-form solutions as the approximate unperturbed solutions, stress effect on the electromagnetic resonances in a dielectric circular disk is studied. Frequency changes of both the transverse electric and transverse magnetic modes are computed for disks of gallium arsenide and under three cases of loading: (1) a pair of diametral forces, (2) steady vertical acceleration, and (3) steady horizontal acceleration. In the latter two cases, the bottom face of the disk is supported by a rigid base. (C) 1996 American Institute of Physics. C1 USA,RES LAB,FT MONMOUTH,NJ 07703. RP Lee, PCY (reprint author), PRINCETON UNIV,DEPT CIVIL ENGN & OPERAT RES,PRINCETON,NJ 08544, USA. NR 6 TC 1 Z9 1 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD FEB 1 PY 1996 VL 79 IS 3 BP 1224 EP 1232 DI 10.1063/1.361015 PG 9 WC Physics, Applied SC Physics GA TT922 UT WOS:A1996TT92200003 ER PT J AU Woolard, DL Buot, FA Rhodes, DL Lu, XJ Lux, RA Perlman, BS AF Woolard, DL Buot, FA Rhodes, DL Lu, XJ Lux, RA Perlman, BS TI On the different physical roles of hysteresis and intrinsic oscillations in resonant tunneling structures SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID DOUBLE-BARRIER STRUCTURES; BISTABILITY; DEVICES; SIMULATION; LIFETIME; DIODES AB Electronic sources based upon resonant tunneling diodes (RTDs) usually generate power by establishing limit cycles which exchange energy with storage elements in an external biasing circuit; hence, the output power in this type of implementation will always be limited by extrinsic effects. We verify the presence of multiple energy-storage mechanisms solely within the RTD and characterizes the interdependencies necessary to induce intrinsic oscillations observed in quantum mechanical simulations. Specifically, we show that a nonlinear ''access'' resistance and quantum-well inductance is responsible for the hysteresis, ''plateaulike'' behavior, and bistability associated with the intrinsic current-voltage (I-V) characteristic. Furthermore, a new circuit-level representation which accurately incorporates the nonlinear dependencies into these heretofore ''linear'' equivalent-circuit elements is used to demonstrate the different roles, as well as the degree of cooperative interplay, of the intrinsic oscillations and hysteresis in determining the overall I-V characteristics of the RTD. C1 USN,RES LAB,WASHINGTON,DC 20375. RP Woolard, DL (reprint author), USA,RES LAB,PSD,FT MONMOUTH,NJ 07703, USA. NR 29 TC 16 Z9 16 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD FEB 1 PY 1996 VL 79 IS 3 BP 1515 EP 1525 DI 10.1063/1.360994 PG 11 WC Physics, Applied SC Physics GA TT922 UT WOS:A1996TT92200045 ER PT J AU Gruber, JB Morrison, CA Seltzer, MD Wright, AO Nadler, MP Allik, TH Hutchinson, JA Chai, BHT AF Gruber, JB Morrison, CA Seltzer, MD Wright, AO Nadler, MP Allik, TH Hutchinson, JA Chai, BHT TI Site-selective excitation and polarized absorption spectra of Nd3+ in Sr-5(PO4)(3)F and Ca-5(PO4)(3)F SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID CRYSTAL-FIELD ANALYSIS; RARE-EARTH IONS; OPTICAL-SPECTRA; ENERGY-LEVELS; LASER; Y2O3 AB Polarized absorption and fluorescence spectra were analyzed to establish individual energy (Stark) levels of Nd3+ ions in host crystals of Sr-5(PO4)(3)F (SFAP) and Ca-5(PO4)(3)F (FAP). Site-selective excitation and fluorescence facilitated differentiation between Nd3+ ions in emitting sites-associated with 1.06 mu m stimulated emission, and nonemitting Nd3+ ions in other sites. Measurements were made on samples containing different concentrations of Nd3+ at 4 K and higher temperatures. Substitution of Nd3+ for Sr2+ or Ca2+ was accompanied by passive charge compensation during crystal growth. Crystal-field splitting calculations were performed according to site for Stark levels of Nd3+ ions identified spectroscopically. We obtained a final set of crystal-field parameters B-nm for Nd3+ ions in fluorescing sites with a rms, deviation of 7 cm(-1) (52 levels in Nd:SFAP) and 8 cm(-1) (59 levels in Nd:FAP). For one of the nonemitting sites in Nd:FAP we obtained a final set of B-nm parameters which gave a rms deviation of 6 cm(-1) between 46 experimental and calculated levels. (C) 1996 American Institute of Physics. C1 USA,RES LAB,ADELPHI,MD 20783. USN,AIR WARFARE CTR,WEAPONS DIV,CHINA LAKE,CA 93555. SCI APPLICAT INT CORP,MCLEAN,VA 22102. USA,NIGHT VIS & ELECTR SENSORS DIRECTORATE,FT BELVOIR,VA 22060. UNIV CENT FLORIDA,CTR RES ELECTROOPT & LASERS,ORLANDO,FL 32836. RP Gruber, JB (reprint author), SAN JOSE STATE UNIV,DEPT PHYS,SAN JOSE,CA 95192, USA. NR 42 TC 29 Z9 29 U1 1 U2 6 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD FEB 1 PY 1996 VL 79 IS 3 BP 1746 EP 1758 DI 10.1063/1.360964 PG 13 WC Physics, Applied SC Physics GA TT922 UT WOS:A1996TT92200077 ER PT J AU Walton, TL AF Walton, TL TI Fill-in of missing data in univariate coastal data SO JOURNAL OF APPLIED STATISTICS LA English DT Article AB An approach to fill-in of missing data where gaps exist within an otherwise continuous record is addressed. Ad hoc methods of past approaches are discussed and limitations noted. Art approach for providing an estimate of data filling consistent with data having a correlation structure is presented. The method provided is an extension of parametric modelling along with additional constraints imposed via a linear filter to account for variance preservation. The method is applied and compared to real data in which a portion of the record has been removed to simulate missing data. Results show the method to provide realistic missing data that preserves the correlation structure and variance of the measured data. C1 USA,CORPS ENGINEERS,COASTAL ENGN RES CTR,WATERWAYS EXPT STN,VICKSBURG,MS 39180. NR 12 TC 3 Z9 3 U1 0 U2 3 PU CARFAX PUBL CO PI ABINGDON PA PO BOX 25, ABINGDON, OXFORDSHIRE, ENGLAND OX14 3UE SN 0266-4763 J9 J APPL STAT JI J. Appl. Stat. PD FEB PY 1996 VL 23 IS 1 BP 31 EP 39 DI 10.1080/02664769624332 PG 9 WC Statistics & Probability SC Mathematics GA UF254 UT WOS:A1996UF25400003 ER PT J AU Smith, WJ Martin, SL Mabrey, JD AF Smith, WJ Martin, SL Mabrey, JD TI Use of a supracondylar nail for treatment of a supracondylar fracture of the femur following total knee arthroplasty SO JOURNAL OF ARTHROPLASTY LA English DT Article DE supracondylar; fracture; total knee arthroplasty; intramedullary fixation AB Treatment of displaced or comminuted supracondylar fractures of the femur following total knee arthroplasty is challenging and problematic. Closed treatment has been associated with malunion, nonunion, and loss of motion, whereas early operative treatment has been associated with infection as well as nonunion. Intramedullary fixation of these fractures has the theoretical advantage of preserving periosteal blood supply while allowing early motion. The use of a nail specifically designed for supracondylar femur fractures to treat a a periprosthetic fracture about a well-fixed total knee arthroplasty is reported. This device provides a valuable treatment option to the surgeon treating this difficult problem. C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. NR 13 TC 24 Z9 24 U1 0 U2 0 PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS PI NEW YORK PA 650 AVENUE OF THE AMERICAS, NEW YORK, NY 10011 SN 0883-5403 J9 J ARTHROPLASTY JI J. Arthroplast. PD FEB PY 1996 VL 11 IS 2 BP 210 EP 213 DI 10.1016/S0883-5403(05)80021-X PG 4 WC Orthopedics SC Orthopedics GA TX399 UT WOS:A1996TX39900021 PM 8648320 ER PT J AU Cardone, VJ Jensen, RE Resio, DT Swail, VR Cox, AT AF Cardone, VJ Jensen, RE Resio, DT Swail, VR Cox, AT TI Evaluation of contemporary ocean wave models in rare extreme events: The ''Halloween storm'' of October 1991 and the ''storm of the century'' of March 1993 SO JOURNAL OF ATMOSPHERIC AND OCEANIC TECHNOLOGY LA English DT Article ID NATIONAL-METEOROLOGICAL-CENTER; WIND-GENERATED WAVES; SURFACE-ANALYSIS; GRAVITY-WAVES; SPECTRA; HURRICANE AB Two recent severe extratropical storms, the ''Halloween storm'' of October 26-November 2 1991 (HOS) and the ''storm of the century'' (SOC) of March 12-15 1993, are characterized by measurements of sea states of unprecedented magnitude off the east coast of North America. A Canadian buoy moored in deep water south of Nova Scotia recorded peak significant wave heights (HS) exceeding 16 m in both storms. In SOC, a NOAA buoy moored southeast of Cape Hatteras recorded a peak HS of 15.7 m, a record high for NOAA buoys. These extreme storm seas (ESS) exceed existing estimates of the 100-yr estimated design wave in these regions by about 50%. The extensive wave measurements made in both storms from buoys moored in deep water provide a rare opportunity to validate modem ocean wave models in wave regimes far more severe than those used for model tuning. In this study, four widely applied spectral wave models (OWI1G, Resio2G, WAM4, and OWI3G) are adapted to the western North Atlantic basin on fine mesh grids and are driven by common wind fields developed for each storm using careful manual kinematic reanalysis. The alternative wave hindcasts are evaluated against time series of measured HS and dominant wave period obtained at nine U.S. and Canadian buoys moored in deep water between offshore Georgia and Newfoundland. In general, it was found that despite the large differences in model formulation, the hindcasts were almost uniformly skillful in specification of the evolution of wave height and period in these two storms. The skill was much greater than achieved routinely in real One wave analyses provided by some of these same models operating at U.S., Canadian, and European centers, confirming that at least for these particular models, typically large errors in operational surface marine wind field analyses are the dominant source of errors in operational wave analyses and forecasts. However, all models were found to systematically underpredict the magnitude of the peak sea states in both storms at buoys that recorded peak HS in excess of about 12 m (ESS). This bias in ESS wave heights was 3.2 m for OWI1G, 1.9 m for Resio2G, 2.2 m for OWI3G, and 1.5 m for WAM4. These results provide an interesting assessment of the progress made in the past decade in ocean wave modeling, both in terms of improvements of 1G and 2G models, and the introduction of 3G models. The 2G and 3G models show a slight advantage over the 1G model in simulating the most extreme wave regimes. These results suggest strongly that, for applications where supercomputers are not available, and especially for most operational applications where only integrated properties of the spectrum (e.g., HS) are required or where errors in forcing wind fields are typical of real time objective analyses and forecasts, highly developed and validated 1G and 2G wave models may continue to be used. However, accurate specification of ESS is especially critical for application of wave models to determine the extreme wave climate for ship, offshore, and coastal structure design. Therefore, further study is required to isolate the contribution of remaining wind field errors and model physics and numerics to the underprediction of ESS in extreme storms. The common phenomenological link between these two storms in the regions of ESS appears to be wave generation along a dynamic fetch associated with intense surface wind maxima or jet streaks (JS), which maintain high spatial coherency over at least 24 h and propagate at speeds of 15-20 m s(-1). ESS were observed only at those buoys directly in the path of the core of such features. This finding suggests that high-resolution wave models are required to model ESS, but these are justified only if the small-scale JS phenomena can be resolved in operational analysis and forecast systems. C1 ENVIRONM CANADA, CLIMATE & ATMOSPHER RES DIRECTORATE, DOWNSVIEW, ON M3H 5T4, CANADA. OCEANWEATHER INC, COS COB, CT USA. USAE, COASTAL ENGN RES CTR, WATERWAYS EXPT STN, VICKSBURG, MS USA. FLORIDA INST TECHNOL, MELBOURNE, FL 32901 USA. NR 42 TC 67 Z9 67 U1 0 U2 5 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0739-0572 J9 J ATMOS OCEAN TECH JI J. Atmos. Ocean. Technol. PD FEB PY 1996 VL 13 IS 1 BP 198 EP 230 DI 10.1175/1520-0426(1996)013<0198:EOCOWM>2.0.CO;2 PG 33 WC Engineering, Ocean; Meteorology & Atmospheric Sciences SC Engineering; Meteorology & Atmospheric Sciences GA UB899 UT WOS:A1996UB89900018 ER PT J AU Stuhmiller, JH Ho, KHH VanderVorst, MJ Dodd, KT Fitzpatrick, T Mayorga, M AF Stuhmiller, JH Ho, KHH VanderVorst, MJ Dodd, KT Fitzpatrick, T Mayorga, M TI A model of blast overpressure injury to the lung SO JOURNAL OF BIOMECHANICS LA English DT Article DE lung; blast injury; injury AB Despite decades of animal experiments, data on blast injury to the lung cover only a limited number of circumstances and are in a fragmented form. This paper develops a mathematical model of the chest wall dynamics and the subsequent generation of strong pressure waves within the lung, which have been hypothesized as the mediator of injury. The model has been compared to an extensive database of observed pathologies from animal tests. The incidence of injury and lethality is found to follow a log-normal correlation with the computed total energy in these waves and, when the energy is normalized by the lung volume, the lethality correlation applies to all large animal species. Small animals also correlate with the normalized energy, but at a different value, and it is speculated that structural differences, other than lung volume, may be involved. This relatively simple model allows the potential for blast injury to the lung to be determined from measured or computed pressure traces without additional animal testing. Improved occupational exposure criteria should follow from this methodology. C1 WALTER REED ARMY INST RES,DEPT RESP RES,WASHINGTON,DC. RP Stuhmiller, JH (reprint author), JAYCOR,APPL SCI & ENGN TECHNOL GRP,9775 TOWNE CTR DR,SAN DIEGO,CA 92121, USA. NR 23 TC 42 Z9 47 U1 2 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0021-9290 J9 J BIOMECH JI J. Biomech. PD FEB PY 1996 VL 29 IS 2 BP 227 EP 234 DI 10.1016/0021-9290(95)00039-9 PG 8 WC Biophysics; Engineering, Biomedical SC Biophysics; Engineering GA TP161 UT WOS:A1996TP16100010 PM 8849816 ER PT J AU Avis, IM Jett, M Boyle, T Vos, MD Moody, T Treston, AM Martinez, A Mulshine, JL AF Avis, IM Jett, M Boyle, T Vos, MD Moody, T Treston, AM Martinez, A Mulshine, JL TI Growth control of lung cancer by interruption of 5-lipoxygenase-mediated growth factor signaling SO JOURNAL OF CLINICAL INVESTIGATION LA English DT Article DE lipoxygenase pathway; 5-HETE; signal transduction; growth inhibition; apoptosis ID LEUKOTRIENE BIOSYNTHESIS INHIBITOR; ARACHIDONIC-ACID; CELLS; BOMBESIN AB Signal transduction pathways shared by different autocrine growth factors may provide an efficient approach to accomplish clinically significant control of lung cancer growth. In this study, we demonstrate that two autocrine growth factors activate 5-lipoxygenase action of the arachidonic acid metabolic pathway in lung cancer cell lines. Both growth factors increased the production of 5(S)-hydrooxyeicosa-6E,8Z,11Z,14Z-tetraenoic acid (5-HETE), a major early 5-lipoxygenase metabolic product. Exogenously added 5-HETE stimulated lung cancer cell growth in vitro. Inhibition of 5-lipoxygenase metabolism by selective antagonists resulted in significant growth reduction for a number of lung cancer cell lines. Primary clinical specimens and lung cancer cell lines express the message for the 5-lipoxygenase enzymes responsible for the generation of active metabolites. In vivo evaluation demonstrated that interruption of 5-lipoxygenase signaling resulted in enhanced levels of programmed cell death. These findings demonstrate that 5-lipoxygenase activation is involved with growth factor-mediated growth stimulation for lung cancer cell lines. Pharmacological intervention with lipoxygenase inhibitors may be an important new clinical strategy to regulate growth factor-dependent stages of lung carcinogenesis. C1 NCI,BIOMARKERS & PREVENT RES BRANCH,ROCKVILLE,MD 20850. WALTER REED ARMY INST RES,DIV PATHOL,WASHINGTON,DC 20307. RI Martinez, Alfredo/A-3077-2013; OI Martinez, Alfredo/0000-0003-4882-4044; Mulshine, James/0000-0002-4648-9177 NR 39 TC 195 Z9 198 U1 0 U2 0 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 222 E 70TH STREET, NEW YORK, NY 10021 SN 0021-9738 J9 J CLIN INVEST JI J. Clin. Invest. PD FEB 1 PY 1996 VL 97 IS 3 BP 806 EP 813 DI 10.1172/JCI118480 PG 8 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA UB656 UT WOS:A1996UB65600030 PM 8609238 ER PT J AU Dooley, DP Garcia, A Kelly, JW Longfield, RN Harrison, L AF Dooley, DP Garcia, A Kelly, JW Longfield, RN Harrison, L TI Validation of catheter semiquantitative culture technique for nonstaphylococcal organisms SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID TIP CULTURES; DIAGNOSIS; INFECTIONS; BACTEREMIA AB The catheter semiquantitative culture roll tip technique has been validated as a discriminator between non-catheter-related bacteremias and catheter-related bacteremias (CRBs) caused by Staphylococcus species. However, this technique has not been specifically validated when used for the evaluation of catheters infected with organisms other than staphylococci. We reviewed catheters that had been submitted for semiquantitative roll tip culture as well as hospital records to determine clinical correlates of infection. Local infection add CRB were defined by standard criteria. Catheter-related sepsis (CRS) was defined as fever, leukocytosis, or hypotension which resolved with catheter removal, without another source of infection. For 195 catheters from 93 patients, gram-negative rods and enterococci were present on 36, fungi were on 25, Corynebacterium species were on 5, Bacillus species were on 3, Staphylococcus species were on 79, and 41 demonstrated no growth. Of 21 episodes of CRB or CRS; due to nonstaphylococcal organisms, only 1 (questionable) episode was due to a catheter with <15 CFU (P < 0.05), Eleven of these 21 episodes of CRB or CRS were due to gram-negative rods and enterococci, of which only the questionable episode was due to a catheter with <15 CFU. Nine of these 21 episodes of CRB or CRS were due to fungi, none of which were associated with a catheter with <15 CFU. The data for Staphylococcus species recapitulated published data (none of 21 CRB or CRS episodes were associated with catheters with <15 CFU) and validated this retrospective technique. The data presented in this study validate the use of the semiquantitative culture technique for the evaluation of catheter-related infections caused by organisms other than staphylococci. C1 BROOKE ARMY MED CTR,DEPT PATHOL,FT SAM HOUSTON,TX 78234. RP Dooley, DP (reprint author), BROOKE ARMY MED CTR,DEPT MED,FT SAM HOUSTON,TX 78234, USA. NR 12 TC 5 Z9 5 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD FEB PY 1996 VL 34 IS 2 BP 409 EP 412 PG 4 WC Microbiology SC Microbiology GA TQ538 UT WOS:A1996TQ53800033 PM 8789025 ER PT J AU Mahoney, DH Strother, D Camitta, B Bowen, T Ghim, T Pick, T Wall, D Yu, L Shuster, JJ Friedman, H AF Mahoney, DH Strother, D Camitta, B Bowen, T Ghim, T Pick, T Wall, D Yu, L Shuster, JJ Friedman, H TI High-dose melphalan and cyclophosphamide with autologous bone marrow rescue for recurrent progressive malignant brain tumors in children: A pilot Pediatric Oncology Group study SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID COLONY-STIMULATING FACTOR; HUMAN MEDULLOBLASTOMA; PHASE-II; EXPERIMENTAL CHEMOTHERAPY; ALKYLATING-AGENTS; THERAPY; TRANSPLANTATION; VINCRISTINE; CHILDHOOD; TRIALS AB Purpose: To determine the maximum-tolerated dose of cyclophosphamide (CTX) when administered sequentially with melphalan 60 mg/m(2)/d for 3 days, followed by autologous bone marrow rescue (ABMR), in children with recurrent or progressive malignant brain tumors, and to make preliminary observations on efficacy. Patients and Methods: Nineteen patients between the ages of 2 and 21 years were enrolled and 18 were assessable for effects of therapy. CTX was administered to seven patients at 750 mg/m(2)/d for 4 days, to five patients at 975 mg/m(2)/d, to three patients at 1,200 mg/m(2)/d, and to three patients at 1,500 mg/m(2)/d. All patients received ABMR. Granulocyte-macrophage colony-stimulating factor (GM-CSF) was used in 15 patients. Toxicity, response to therapy, time to progression, and survival were monitored. Results: The median time to a granulocyte count more than 500/dL was 19 days (range, 11 to 39), and for a platelet count more than 50,000/dL was 33 days (range, 16 to 60). Four heavily pretreated patients (22%) died of transplant-related complications. No dose-limiting, nonhematologic toxicities were defined for the study. Seven of 18 patients (39%) had a complete response (CR) or a partial response (PR). These included four patients with medulloblastoma (CR and three PRs), two with germinomas (two CRs), and one with ependymoma (one CR). The estimated 1-year survival rate was 39% (SE 12%). Conclusion: CTX, at a maximum total dose of 6,000 mg/m(2), administered sequentially with melphalan and followed by ABMR was tolerable in children with recurrent brain tumors who had not been heavily pretreated. Responses were seen in patients with medulloblastoma and germinomas. Further trials in children with chemosensitive tumors, with minimal residual disease, are planned. (C) 1996 by American Society of Clinical Oncology. C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. BAYLOR COLL MED,DEPT PEDIAT,HOUSTON,TX 77030. MIDWEST CHILDRENS CANC CTR,MILWAUKEE,WI. ALBERTA CHILDRENS PROV GEN HOSP,CALGARY,AB,CANADA. EMORY UNIV,SCH MED,ATLANTA,GA. UNIV WASHINGTON,MED CTR,ST LOUIS,MO. CHILDRENS HOSP NEW ORLEANS,NEW ORLEANS,LA. UNIV FLORIDA,PEDIAT ONCOL GRP,STAT OFF,GAINESVILLE,FL 32611. DUKE UNIV,MED CTR,DURHAM,NC. FU NCI NIH HHS [CA-53490, CA-32053, CA-03161] NR 41 TC 83 Z9 83 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD FEB PY 1996 VL 14 IS 2 BP 382 EP 388 PG 7 WC Oncology SC Oncology GA TU998 UT WOS:A1996TU99800010 PM 8636747 ER PT J AU Million, A Dhar, NK Dinan, JH AF Million, A Dhar, NK Dinan, JH TI Heteroepitaxy of CdTe on {211}Si substrates by molecular beam epitaxy SO JOURNAL OF CRYSTAL GROWTH LA English DT Article; Proceedings Paper CT 7th International Conference on II-VI Compounds and Devices CY AUG 13-18, 1995 CL HERIOT WATT UNIV, EDINBURGH, SCOTLAND SP Heriot Watt Univ, Lothian & Edinburgh Enterprise Ltd, City Edinburgh, VG Semicon Ltd, EPI, Sony Corp, Megatech, Compound Semiconductor Magazine, III Vs Rev, Johnson Matthey, Oxford Appl Res, Thomas Swan, Spectra Phys HO HERIOT WATT UNIV ID SURFACE PASSIVATION; HGCDTE; ARRAYS AB Direct growth of (211)CdTe on Si has been achieved by molecular beam epitaxy, We adopted techniques for substrate preparation that do not require heating above 540 degrees C. Si surfaces treated with As were found to produce the best nucleation. A growth schedule, interrupted multi-layer anneal cycle, was used to improve the crystal quality of the epilayer. Single domain and good surface morphology were produced,Values for full width at half maximum of the (422)CdTe X-ray reflection were as low as 106 arcsec. Transmission electron microscopy has shown the advantages of the IMAC process on the confinement of the growth defects near the interface. C1 USA,RES LAB,FT BELVOIR,VA 22060. NIGHT VIS & ELECT SENSORS DIRECTORATE,FT BELVOIR,VA 22060. RP Million, A (reprint author), CEN GRENOBLE,LETI CEA TECHNOL AVANCEES,DOPT,17 RUE MARTYRS,F-38054 GRENOBLE 9,FRANCE. NR 17 TC 41 Z9 42 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0248 J9 J CRYST GROWTH JI J. Cryst. Growth PD FEB PY 1996 VL 159 IS 1-4 BP 76 EP 80 DI 10.1016/0022-0248(95)00777-6 PG 5 WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied SC Crystallography; Materials Science; Physics GA UH324 UT WOS:A1996UH32400017 ER PT J AU Kuppurao, S Brandon, S Derby, JJ AF Kuppurao, S Brandon, S Derby, JJ TI Analysis of interrupted growth strategies for cadmium telluride in an unseeded vertical Bridgman system SO JOURNAL OF CRYSTAL GROWTH LA English DT Article ID DILUTE BINARY-ALLOYS; CRYSTAL-GROWTH; CD-TE; CDXHG1-XTE; HGCDTE; SEGREGATION; CONVECTION; SOLIDIFICATION; SIMULATION; DYNAMICS AB A transient, non-dilute finite element model is employed to study a novel, interrupted growth strategy which has been employed for the unseeded, vertical Bridgman growth of cadmium telluride. Computations clearly show the time-dependent translation strategy causes solute diffusion layers in the melt to successively grow and die in time, thus providing a means to mix the cadmium rejected at the growth interface into the bulk. This strategy stabilizes the solid-liquid interface by delaying the onset of constitutional supercooling, thus allowing the use of growth rates for grain selection which are higher than would be possible using continuous translation. C1 UNIV MINNESOTA,DEPT CHEM ENGN & MAT SCI,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,ARMY HPC RES CTR,MINNEAPOLIS,MN 55455. TECHNION ISRAEL INST TECHNOL,DEPT CHEM ENGN,IL-32000 HAIFA,ISRAEL. RI Derby, Jeffrey/B-9706-2009; OI Derby, Jeffrey/0000-0001-6418-2155 NR 43 TC 36 Z9 36 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0248 J9 J CRYST GROWTH JI J. Cryst. Growth PD FEB PY 1996 VL 158 IS 4 BP 459 EP 470 DI 10.1016/0022-0248(95)00485-8 PG 12 WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied SC Crystallography; Materials Science; Physics GA TU513 UT WOS:A1996TU51300012 ER PT J AU Tamargo, MC Cavus, A Zeng, LF Dai, N Bambha, N Gray, A Semendy, F Krystek, W Pollak, FH AF Tamargo, MC Cavus, A Zeng, LF Dai, N Bambha, N Gray, A Semendy, F Krystek, W Pollak, FH TI MBE growth of lattice-matched ZnCdMgSe quaternaries and ZnCdMgSe/ZnCdSe quantum wells on InP substrates SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT Electronic Materials Conference CY JUN 21-23, 1995 CL CHARLOTTESVILLE, VA DE II-VI compounds; II-VI/III-V heteroepitaxy; blue emitters; molecular beam epitaxy; wide bandgap semiconductors; (Zn,Cd,Mg)Se ID LASERS AB We report the growth and characterization of a new wide bandgap II-VI alloy, ZnxCdyMg1-x-ySe, grown lattice-matched to InP. High quality quaternary layers with bandgaps ranging from 2.4 to 3.1 eV were grown by molecular beam epitaxy. The bandgaps and lattice constants were measured using photoluminescence and single crystal Theta-2 Theta scans. Quantum well structures with quaternary barriers and ZnCdSe wells were also grown, entirely lattice matched to InP. Their photoluminescence properties suggest that these materials are suitable for the design of visible semiconductor lasers spanning the blue, green, and yellow regions of the visible range. The absence of strain in these heterostructures is expected to improve the reliability of the materials in device applications. C1 CUNY CITY COLL,DEPT CHEM,NEW YORK,NY 10031. CUNY CITY COLL,NY STATE CTR ADV TECHNOL ULTRAFAST PHOTON MAT & A,NEW YORK,NY 10031. USA,OFS,IR OPT TECHNOL,FT BELVOIR,VA 22060. CUNY BROOKLYN COLL,DEPT PHYS,BROOKLYN,NY 11210. RP Tamargo, MC (reprint author), CUNY CITY COLL,CTR ANAL STRUCT & INTERFACES,NEW YORK,NY 10031, USA. NR 10 TC 40 Z9 40 U1 0 U2 2 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 420 COMMONWEALTH DR, WARRENDALE, PA 15086 SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD FEB PY 1996 VL 25 IS 2 BP 259 EP 262 DI 10.1007/BF02666254 PG 4 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA TU672 UT WOS:A1996TU67200016 ER PT J AU Gold, VM Vradis, GC Pearson, JC AF Gold, VM Vradis, GC Pearson, JC TI Concrete penetration by eroding projectiles: Experiments and analysis SO JOURNAL OF ENGINEERING MECHANICS LA English DT Article ID IMPACT AB Spherical-nose copper and tantalum rods with aspect ratios between 4.0 and 14.6 were gun launched against 91-cm-diameter and 91-cm-long concrete and simulant reinforced-concrete targets with velocities ranging from 0.15 cm/mu s to 0.19 cm/mu s. Targets were instrumented with a sequence of break gauges that provided valuable data for characterizing the penetration process. Target-hole profiles and projectile residual masses were measured and reported. Analysis of the penetration performance of projectiles was performed within the framework of the modified hydrodynamic theory of pen'etration. Based on the results of these calculations, the penetration efficiencies of the copper and the tantalum projectiles were compared as functions of impact velocities. Analysis of the penetration resistance of the simulant reinforced-concrete targets was based on treating the targets as ''composites,'' comprised of layers of concrete proper and reinforcing steel; the results of these calculations were compared with the experimental data. Using this theory, the penetration resistance of a concrete/steel/concrete ''composite'' was investigated as a function of the following parameters: thickness of the surface layer of the concrete, thickness of the steel reinforcement, and impact velocity. C1 POLYTECH INST NEW YORK, DEPT MECH ENGN, METROTECH CTR 6, BROOKLYN, NY 11201 USA. RP Gold, VM (reprint author), USA, ARDED, ENERGET & WARHEADS DIV, WARHEADS GRP, PICATINNY ARSENAL, NJ 07806 USA. NR 26 TC 7 Z9 11 U1 0 U2 2 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9399 EI 1943-7889 J9 J ENG MECH JI J. Eng. Mech. PD FEB PY 1996 VL 122 IS 2 BP 145 EP 152 DI 10.1061/(ASCE)0733-9399(1996)122:2(145) PG 8 WC Engineering, Mechanical SC Engineering GA TR922 UT WOS:A1996TR92200009 ER PT J AU Gasparini, DA Bonacuse, P Powers, L Romeo, A AF Gasparini, DA Bonacuse, P Powers, L Romeo, A TI Stochastic parallel-brittle networks for modeling materials SO JOURNAL OF ENGINEERING MECHANICS-ASCE LA English DT Article ID BUNDLES PROBABILITY MODEL; FIBROUS MATERIALS; COMPOSITES; ALGORITHMS; FRACTURE; STRENGTH; MESHES AB The behavior of Voronoi-Delaunay parallel-brittle networks of truss elements as models for material behavior is studied. Means and variances of both the number of elements in a network and their length are given. The uniaxial stiffness of the networks is found equal to the element axial stiffness. The expected value of the network's uniaxial-tensile strength is proportional to the square root of the expected number of elements and to the expected value of the strength of the elements. The toughness of the networks is proportional to the square of the expected value of element strength and to the square root of the expected number of elements. An application to pullout of an anchor is presented. Daniels systems and chain-of-bundles systems are also analyzed to provide perspective. Statistical size effects for parallel-brittle networks are quite different form those associated with weak-link systems. C1 NASA,LEWIS RES CTR,ARMY RES LAB,CLEVELAND,OH 44135. CLEVELAND STATE UNIV,DEPT CIVIL ENGN,CLEVELAND,OH 44115. CASE WESTERN RESERVE UNIV,DEPT CIVIL ENGN,CLEVELAND,OH 44106. RP Gasparini, DA (reprint author), CASE WESTERN RESERVE UNIV,DEPT CIVIL ENGN,CLEVELAND,OH 44106, USA. NR 23 TC 2 Z9 2 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9399 J9 J ENG MECH-ASCE JI J. Eng. Mech.-ASCE PD FEB PY 1996 VL 122 IS 2 BP 130 EP 137 DI 10.1061/(ASCE)0733-9399(1996)122:2(130) PG 8 WC Engineering, Mechanical SC Engineering GA TR922 UT WOS:A1996TR92200007 ER PT J AU Dan, JA Belyea, DA Lieberman, MF Stamper, RL AF Dan, JA Belyea, DA Lieberman, MF Stamper, RL TI Evaluation of optic disc measurements with the glaucoma-scope SO JOURNAL OF GLAUCOMA LA English DT Article DE glaucoma; scope; reproducibility; weighted Kappa; inter- and intraobserver; reliability ID FIBER LAYER THICKNESS; TOPOGRAPHIC MEASUREMENTS; NERVE HEAD; AGREEMENT; REPRODUCIBILITY; ANALYZER AB Purpose: We evaluated the Glaucoma-Scope's ability to acquire images of the optic disc, the reproducibility of its analysis, and the comparison between it and expert evaluation. Methods: One hundred and sixty-eight patients with satisfactory standard fundus photography were referred for Glaucoma-Scope analysis. Characteristics of eyes in which Glaucoma-Scope analysis could not be obtained were evaluated. Eight glaucoma patients (15 eyes) were quantitatively evaluated: inter- and intraobserver reproducibility of the Glaucoma-Scope analyses were calculated utilizing weighted Kappa index of agreement and coefficient of variation. The Glaucoma-Scope cup-to-disc ratio was calculated from the gray scale analysis and compared to the ratio as evaluated by a glaucoma expert. Results: Glaucoma-Scope analysis was not achieved in 14% of a total of 336 eyes of 168 patients. The conditions associated with the inability to obtain a satisfactory image were hyperpigmented fundi, pseudophakia, aphakia, corneal opacities, cataract, and contact lenses. The quantitative analysis of the 15 patients showed small inter- and intraobserver means of the coefficient of variation (0.136 +/- 0.023 and 0.129 +/- 0.016) and SD (0.063 +/- 0.0056 and 0.064 +/- 0.0077) and moderate-substantial intra- and interobserver agreement (weighted K = 0.427 +/- 0.1 and 0.61 +/- 0.14, respectively). Significant disagreement (weighted K = - 0.11, p = 0.0023) was found between Glaucoma-Scope (mean 0.52 +/- 0.064) and expert's evaluations (0.673) of the cup-to-disc ratio, Conclusions: The inter- and intraobserver reliability and low variation of the Glaucoma-Scope readings indicates moderate to substantial reproducibility for detecting changes in optic disc's topography under selected conditions. However, eyes with moderate cataract, aphakia, pseudophakia, mild corneal opacity, darkly pigmented fundi or myopia were inconsistently analyzable. In a small group of randomly selected eyes there was very low agreement between the glaucoma expert's evaluation of the optic disc and that of the Glaucoma-Scope. These findings raise questions about the usefulness of the instrument as a diagnostic tool for glaucoma but show promise for detecting change when good images are possible. C1 WALTER REED ARMY MED CTR,OPHTHALMOL SERV,WASHINGTON,DC 20307. NR 21 TC 12 Z9 12 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1057-0829 J9 J GLAUCOMA JI J. Glaucoma PD FEB PY 1996 VL 5 IS 1 BP 1 EP 8 PG 8 WC Ophthalmology SC Ophthalmology GA UC786 UT WOS:A1996UC78600002 PM 8795727 ER PT J AU Mascola, JR Snyder, SW Weislow, OS Belay, SM Belshe, RB Schwartz, DH Clements, ML Dolin, R Graham, BS Gorse, GJ Keefer, MC McElrath, MJ Walker, MC Wagner, KF McNeil, JG McCutchan, FE Burke, DS AF Mascola, JR Snyder, SW Weislow, OS Belay, SM Belshe, RB Schwartz, DH Clements, ML Dolin, R Graham, BS Gorse, GJ Keefer, MC McElrath, MJ Walker, MC Wagner, KF McNeil, JG McCutchan, FE Burke, DS TI Immunization with envelope subunit vaccine products elicits neutralizing antibodies against laboratory-adapted but not primary isolates of human immunodeficiency virus type 1 SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID FELINE LEUKEMIA-VIRUS; SOLUBLE CD4; RECOMBINANT GP160; MONOCLONAL-ANTIBODY; GLYCOPROTEIN GP120; HIV-1 INFECTION; SCD4 BINDING; CHIMPANZEES; PROTECTION; IMMUNOGENICITY AB Phase I studies of volunteers not infected with human immunodeficiency virus type 1 (HIV-1) have shown that immunization with envelope subunit vaccine products elicits antibodies that neutralize laboratory-adapted (prototype) HIV-1 strains in vitro, Prototype strains are adapted to grow in continuous (neoplastic) cell lines and are more susceptible to neutralization than are primary isolates cultured in human peripheral blood mononuclear cells, In this study, 50 sera from nine phase I vaccine trials and 16 from HIV-1-infected persons were evaluated for neutralizing antibody activity against 3 laboratory-adapted and 5 primary HIV-1 isolates, Of 50 sera, 49 neutralized at least 1 of the prototype strains; however, none displayed neutralizing activity against primary isolates of HIV-1, Serum from most HIV-1-infected persons neutralized both laboratory-adapted and primary HIV-1 isolates, These data demonstrate a qualitative, or large quantitative, difference in the neutralizing antibody response induced by envelope subunit vaccination and natural HIV-1 infection. C1 SRA TECHNOL INC,ROCKVILLE,MD. USN,MED RES INST,DEPT INFECT DIS,BETHESDA,MD. NIAID,BETHESDA,MD 20892. JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,BALTIMORE,MD 21205. SCH MED,BALTIMORE,MD. ST LOUIS UNIV,SCH MED,DEPT MED,ST LOUIS,MO. UNIV ROCHESTER,SCH MED & DENT,DEPT MED,NEW YORK,NY. VANDERBILT UNIV,SCH MED,DEPT MED,NASHVILLE,TN 37212. WASHINGTON UNIV,SCH MED,DEPT MED,SEATTLE,WA. RP Mascola, JR (reprint author), WALTER REED ARMY INST RES,DIV RETROVIROL,HENRY M JACKSON FDN ADV MIL MED,13 TAFT CT,ROCKVILLE,MD 20850, USA. OI /0000-0002-5704-8094 FU NIAID NIH HHS [AI-05063, AI-05064, AI-05061] NR 67 TC 369 Z9 372 U1 2 U2 7 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD FEB PY 1996 VL 173 IS 2 BP 340 EP 348 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA TT665 UT WOS:A1996TT66500009 PM 8568294 ER PT J AU Relman, DA Schmidt, TM Gajadhar, A Sogin, M Cross, J Yoder, K Sethabutr, O Echeverria, P AF Relman, DA Schmidt, TM Gajadhar, A Sogin, M Cross, J Yoder, K Sethabutr, O Echeverria, P TI Molecular phylogenetic analysis of Cyclospora, the human intestinal pathogen, suggests that it is closely related to Eimeria species SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID RIBOSOMAL-RNA; EVOLUTIONARY RELATIONSHIPS; ORGANISM; SEQUENCE; DIARRHEA; CLONING; MURIS; NEPAL AB A coccidian organism assigned to the genus Cyclospora has been increasingly recognized in association with prolonged diarrhea in humans throughout the world, Confusion surrounds the taxonomy of this fastidious organism, despite the availability of morphology and sporulation characteristics, The small subunit rRNA coding region from cyclosporan oocysts purified from a human fecal specimen was amplified and sequenced, The same sequence was present in specimens from 8 other patients with cyclosporan oocysts but absent in specimens from asymptomatic subjects and from cryptosporidiosis patients, Phylogenetic analysis of rDNA sequences reveals that the human-associated Cyclospora is closely related to members of the Eimeria genus, These results allow predictions concerning Cyclospora host specificity, life cycle, and epidemiology as well as the development of a specific polymerase chain reaction-based diagnostic assay. C1 STANFORD UNIV,SCH MED,DEPT MED,STANFORD,CA. STANFORD UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL,STANFORD,CA. STANFORD UNIV,SCH MED,CTR DIGEST DIS,STANFORD,CA. MICHIGAN STATE UNIV,DEPT MICROBIOL,E LANSING,MI 48824. AGR CANADA,HLTH ANIM LAB,SASKATOON,SK S7N 2R3,CANADA. MARINE BIOL LAB,CTR MOLEC EVOLUT,WOODS HOLE,MA 02543. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. ARMED FORCES RES INST MED SCI,DEPT BACTERIOL IMMUNOL & MOLEC GENET,BANGKOK 10400,THAILAND. RP Relman, DA (reprint author), VA PALO ALTO HLTH CARE SYST 154T,3801 MIRANDA AVE,PALO ALTO,CA 94304, USA. OI Yoder, Kristine/0000-0002-5598-9018; Schmidt, Thomas/0000-0002-8209-6055 FU NIGMS NIH HHS [GM-32964] NR 32 TC 132 Z9 141 U1 0 U2 5 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD FEB PY 1996 VL 173 IS 2 BP 440 EP 445 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA TT665 UT WOS:A1996TT66500022 PM 8568307 ER PT J AU Kiang, JG Ding, XZ McClain, DE AF Kiang, JG Ding, XZ McClain, DE TI Thermotolerance attenuates heat-induced increases in [Ca2+](i) and HSP-72 synthesis but not heat-induced intracellular acidification in human a-431 cells SO JOURNAL OF INVESTIGATIVE MEDICINE LA English DT Article DE heat shock protein; calcium; amiloride; pH; thermotolerance ID CYTOSOLIC FREE CA2+; TRANSLATIONAL THERMOTOLERANCE; GENE-EXPRESSION; SHOCK PROTEINS; STRESS; HSP70; INDUCTION; PROTECTS; EXCHANGE; INHIBITION AB Background: Thermotolerance affects cell viability, retards translation of heat shock proteins, and protects RNA slicing mechanisms, We reported previously that heat shocking nonthermotolerant cells causes an intracellular acidification and an increase in cytosolic free Ca2+ ([Ca2+](i)) in addition to an induction of heat shock protein 72 kDa (HSP-72) production, This study characterized heat-induced changes in cytosolic Ca2+, H+, and HSP-72 synthesis in thermotolerant A-431 cells. Methods: We studied heat-induced changes in pH(i), [Ca2+](i), and HSP-72 using thermotolerant A-431 cell monolayers, pH(i) and [Ca2+](i) were determined using fluorescence probes, and HSP-72 was measured by SDS-PAGE, The mRNA encoding HSP-72 was measured by Northern blots probed with a [P-32]-labeled 2.3 kb fragment of an HSP-70 cDNA insert. Results: Heat shocking thermotolerant cells induced the same degree of intracellular acidification as that induced in nonthermotolerant cells, but the heat-induced increase in [Ca2+](i) was less in thermotolerant cells, This diminished response was characterized by an increase in K-m for external Ca2+ and was blocked by pretreatment with cycloheximide, indicating a newly synthesized protein is involved, Similar to what was seen in nonthermotolerant cells, the heat-induced increase in [Ca2+](i) in thermotolerant cells depended on external Na+ concentration and was blocked by dichlorobenzamil, though thermotolerant cells were more sensitive to the inhibitor (IC50 = 0.21 mu mol/L for nonthermotolerant, 0.025 mu mol/Lm for thermotolerant), Thermotolerant cells contained high resting levels of HSP-72, Heat shocking these cells attenuated the HSF translocation from cytosol to nucleus and did not induce a further synthesis of HSP-72 mRNA and protein. Conclusions: The results suggest that thermotolerance desensitizes the machinery required for Ca2+ entry, Low [Ca2+](i) levels probably result in diminished HSP-72 mRNA production and less HSP-72 synthesis. C1 ARMED FORCES RADIOBIOL RES INST,DEPT RADIAT BIOCHEM,BETHESDA,MD. WALTER REED ARMY INST RES,DEPT CLIN PHYSIOL,DIV MED,WASHINGTON,DC 20307. NR 41 TC 19 Z9 22 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 1081-5589 J9 J INVEST MED JI J. Invest. Med. PD FEB PY 1996 VL 44 IS 2 BP 53 EP 63 PG 11 WC Medicine, General & Internal; Medicine, Research & Experimental SC General & Internal Medicine; Research & Experimental Medicine GA TY729 UT WOS:A1996TY72900006 PM 8689402 ER PT J AU Maneerat, Y Clayson, ET Myint, KSA Young, GD Innis, BL AF Maneerat, Y Clayson, ET Myint, KSA Young, GD Innis, BL TI Experimental infection of the laboratory rat with the hepatitis E virus SO JOURNAL OF MEDICAL VIROLOGY LA English DT Article DE HEV; RT-PCR; HEV transmission; viral hepatitis; animal model ID NON-B HEPATITIS; TRANSMITTED NON-A; EPIDEMIC NON-A; ENTERIC NON-A; CYNOMOLGUS MACAQUES; MACACA-MULATTA; LIVER-DAMAGE; TRANSMISSION; ROUTE; HEV AB To confirm an earlier report that laboratory rats are susceptible to infection with the hepatitis E virus (HEV), we inoculated 27 Wistar rats intravenously with a suspension of a human stool known to contain infectious HEV. Stool, sera, and various tissues were collected from three rats each on days 0 (preinoculation) and 4, 7, 11, 14, 18, 21, 25, 28, and 35 postinoculation. Stool and sera specimens were examined by reverse transcription-polymerase chain reaction for the presence of HEV genomic sequences. Tissues were examined by light microscopy for detection of histopathological changes and by direct immunofluorescence for detection of HEV antigens. We detected HEV RNA in stools on day 7 in all three animals and in serum intermittently between days 4 and 35. We found HEV antigens in liver, peripheral blood mononuclear cells, spleen, mesenteric lymph nodes, and small intestine. We detected histopathology attributable to the inoculum in liver, spleen, and lymph nodes. The results confirm that HEV can replicate in laboratory rats and suggest new tissue sites for HEV replication. (C) 1996 Wiley-Liss, Inc.* C1 USA MED COMPONENT, ARMED FORCES RES INST MED SCI, DEPT VET MED, BANGKOK, THAILAND. USA MED COMPONENT, ARMED FORCES RES INST MED SCI, DEPT VIROL, BANGKOK, THAILAND. MAHIDOL UNIV, DEPT PATHOBIOL, BANGKOK, THAILAND. RP Maneerat, Y (reprint author), USA MED COMPONENT, ARMED FORCES RES INST MED SCI, DEPT VIROL, APO, AP 96546 USA. NR 36 TC 83 Z9 88 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0146-6615 J9 J MED VIROL JI J. Med. Virol. PD FEB PY 1996 VL 48 IS 2 BP 121 EP 128 PG 8 WC Virology SC Virology GA TU189 UT WOS:A1996TU18900001 PM 8835343 ER PT J AU Johnson, KE Harmon, RS Richardson, JM Moorbath, S Strong, DF AF Johnson, KE Harmon, RS Richardson, JM Moorbath, S Strong, DF TI Isotope and trace element geochemistry of Augustine Volcano, Alaska: Implications for magmatic evolution SO JOURNAL OF PETROLOGY LA English DT Article DE Augustine Volcano; Aleutians; assimilation; metasomatism; geochemistry ID ISLAND-ARC MAGMAS; EASTERN ALEUTIAN ARC; CALC-ALKALINE; SR ISOTOPES; PLUMBING SYSTEMS; PACIFIC-OCEAN; BERING SEA; CONSTRAINTS; ROCKS; BASALT AB Augustine Volcano, a Quaternary volcanic centre of the eastern Aleutian Are, Produces predominantly andesites and dacites of low- to medium-K calc-alkaline composition. Mineralogical and major element characteristics of representative lavas suggest that magmatic evolution has been influenced by both crystal fractionation and magma-mixing processes. However, incompatible trace element variations (e.g. K/Rb) indicate that these evolved lavas have been contaminated by the mafic are crust of the underlying Talkeetna accreted terrane. The limited range of isotope compositions also supports the assimilation of non-radiogenic mafic crust (e.g. Sr-87/Sr-86=0.7032-0.7034; Nd-143/Nd-144=0.51301-0.5130). In addition, Pb-isotope mean oceanic trend (Pb-206/Pb-204=18.3-18.8; Pb-207/Pb-204=15.5-15.6; Pb-208/Pb-204=38.2-38.3) and do not require a subducted sediment component in the source. Relatively high (Ba/La)(N) (0.79-18.10) and B/Be (14.5) ratios do, however, suggest a metasomatic fluid component derived from the dehydration of the subducting plate. The thickened continental crust (similar to 35 km) of the eastern Aleutian Are prevents the ascent of basaltic melts, which fractionate and assimilate at various depths to produce andesitic magmas. These andesites evolve towards more silicic compositions by fractional crystallization. The absence of evidence for a large high-level crustal magma chamber implies that the magmatic system beneath the volcano is young and at an immature stage of evolution. C1 UNIV FLORIDA, DEPT GEOL, GAINESVILLE, FL 32611 USA. USA, RES OFF, RES TRIANGLE PK, NC 27709 USA. ONTARIO GEOL SURVEY, GEOSCI BRANCH, WILLET GREEN MILLER CTR, SUDBURY, ON P3E 6B5, CANADA. UNIV OXFORD, DEPT EARTH SCI, OXFORD OX1 3PR, ENGLAND. UNIV VICTORIA, CTR EART & OCEAN RES, VICTORIA, BC V8W 3P6, CANADA. NR 93 TC 21 Z9 26 U1 0 U2 9 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0022-3530 J9 J PETROL JI J. Petrol. PD FEB PY 1996 VL 37 IS 1 BP 95 EP 115 DI 10.1093/petrology/37.1.95 PG 21 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA TZ716 UT WOS:A1996TZ71600006 ER PT J AU Byrne, MP Broomfield, CA Stites, WE AF Byrne, MP Broomfield, CA Stites, WE TI Mustard gas crosslinking of proteins through preferential alkylation of cysteines SO JOURNAL OF PROTEIN CHEMISTRY LA English DT Article DE mustard gas; crosslinked dimer; staphylococcal nuclease; cysteine ID STAPHYLOCOCCAL NUCLEASE; SULFUR MUSTARD; CRYSTAL-STRUCTURE; BIOLOGICAL FATE; AMINO-ACIDS; STABILITY; STATE; SKIN; DNA; RAT AB Mustard gas, bis(2-chloroethyl)sulfide, treatment of proteins is shown to generate significant amounts of covalently crosslinked protein dimers. This is due to the preferential alkylation of cysteine residues. Crosslinking does not occur in the model protein staphylococcal nuclease, which has no cysteine residues. Treatment of cysteine-containing mutants of staphylococcal nuclease with this chemical warfare agent did result in crosslinking. However, these dimers are slowly cleaved back to monomers by an unknown mechanism. The alkylation and crosslinking of cysteine-containing proteins by mustard gas may contribute to its toxicity. C1 UNIV ARKANSAS,DEPT CHEM & BIOCHEM,FAYETTEVILLE,AR 72701. USA,MED RES INST CHEM DEF,BIOCHEM PHARMACOL BRANCH,ABERDEEN PROVING GROUND,MD 21010. RI Stites, Wesley/D-5348-2013 OI Stites, Wesley/0000-0002-9334-3760 NR 35 TC 20 Z9 20 U1 0 U2 3 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0277-8033 J9 J PROTEIN CHEM JI J. Protein Chem. PD FEB PY 1996 VL 15 IS 2 BP 131 EP 136 DI 10.1007/BF01887394 PG 6 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA UD274 UT WOS:A1996UD27400002 PM 8924198 ER PT J AU Fell, NF Widder, JM Medlin, SV Morris, JB PesceRodriguez, RA McNesby, KL AF Fell, NF Widder, JM Medlin, SV Morris, JB PesceRodriguez, RA McNesby, KL TI Fourier transform Raman spectroscopy of some energetic materials and propellant formulations .2. SO JOURNAL OF RAMAN SPECTROSCOPY LA English DT Article AB Fourier transform Raman spectroscopy employing near-infrared laser radiation at a wavelength of 1.064 pm (9394.5 cm(-1)) as the scattering source was used to characterize neat energetic materials and several propellant formulations. Raman spectra are reported over the region from 75 to 3000 cm(-1), relative to the laser line. The technique was extended to the study of crystalline components of propellant formulations during heating. The utility of the technique in determining the principal crystalline ingredient in a propellant formulation is demonstrated. C1 USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005. NR 4 TC 30 Z9 30 U1 2 U2 9 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0377-0486 J9 J RAMAN SPECTROSC JI J. Raman Spectrosc. PD FEB PY 1996 VL 27 IS 2 BP 97 EP 104 DI 10.1002/(SICI)1097-4555(199602)27:2<97::AID-JRS931>3.0.CO;2-P PG 8 WC Spectroscopy SC Spectroscopy GA TX291 UT WOS:A1996TX29100002 ER PT J AU Schwartz, BF Auman, R Peretsman, SJ Moul, JW Deshon, GE Hernandez, J Rozanski, TA Thrasher, JB AF Schwartz, BF Auman, R Peretsman, SJ Moul, JW Deshon, GE Hernandez, J Rozanski, TA Thrasher, JB TI Prognostic value of BHCG and local tumor invasion in stage I seminoma of the testis SO JOURNAL OF SURGICAL ONCOLOGY LA English DT Article DE beta human chorionic gonadotropin; tumor markers; radiotherapy; testicular cancer ID HUMAN CHORIONIC-GONADOTROPIN; ALPHA-FETOPROTEIN; RADIATION-THERAPY; CELLS; HCG AB Approximately 10-15% of patients with stage I pure seminoma of the testis have an elevated preorchiectomy serum beta human chorionic gonadotropin level [1-4]. The prognostic significance of this elevation is unknown. We performed a multi-institutional retrospective review of 332 men with stage I pure seminoma of the testis and evaluated the prognostic significance of this elevation and the prognostic value of local invasion of the primary tumor. Twenty-five of 191 evaluable patients (13%) had elevated preorchiectomy beta human chorionic gonadotropin. All normalized postoperatively and are alive without evidence of disease with a median follow-up of 50 months (range 1-124 mo). Of 191 patients, 190 (99.5%) are alive and free of disease. One patient underwent salvage chemotherapy for a chest recurrence, and he is alive and free of disease at 72 months. We conclude that elevated preorchiectomy serum beta human chorionic gonadotropin level and local invasion of the primary tumor do not portend a poor prognosis in patients with clinical stage I pure seminoma of the testis. (C) 1996 Wiley-Liss, Inc. C1 PORTSMOUTH NAVAL HOSP,DEPT UROL,PORTSMOUTH,VA. WILFORD HALL USAF MED CTR,DEPT UROL,SAN ANTONIO,TX 78236. WALTER REED ARMY MED CTR,DEPT UROL,WASHINGTON,DC 20307. TRIPLER ARMY MED CTR,DEPT UROL,HONOLULU,HI 96859. BROOKE ARMY MED CTR,DEPT UROL,SAN ANTONIO,TX. RP Schwartz, BF (reprint author), MADIGAN ARMY MED CTR,DEPT UROL,TACOMA,WA 98431, USA. NR 11 TC 8 Z9 8 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0022-4790 J9 J SURG ONCOL JI J. Surg. Oncol. PD FEB PY 1996 VL 61 IS 2 BP 131 EP 133 DI 10.1002/(SICI)1096-9098(199602)61:2<131::AID-JSO7>3.0.CO;2-D PG 3 WC Oncology; Surgery SC Oncology; Surgery GA TV763 UT WOS:A1996TV76300007 PM 8606544 ER PT J AU Li, YL White, MJ AF Li, YL White, MJ TI Near-field computation for sound propagation above ground - Using complex image theory SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID IMPEDANCE PLANE; SURFACE AB In this paper, a very simple method is introduced for the efficient computation of the sound field in the near region above an impedance ground or an extended reaction ground. The procedure is based on complex image theory. Using Prony's method, the slowly varying factor in the integrand of the Sommerfeld integral is approximated by a short series in terms of complex exponential functions. The result can be exactly evaluated by the Sommerfeld identity. A new closed-form approximate expression of the sound field is obtained, which is represented as the original source, its quasistatic image, and several ''images'' with complex amplitudes and positions. Avoiding numerical evaluation of the Sommerfeld integral makes these closed-form expressions computationally very efficient. The representation of the field with complex images makes the formula useful in measurement of ground impedance or in other cases requiring repeated mapping of the sound field. Numerical results show that these closed-form Green's functions are very accurate for the computation of the near field. (C) 1996 Acoustical Society of America. C1 USA, CONSTRUCT ENGN RES LAB, CHAMPAIGN, IL 61826 USA. RP Li, YL (reprint author), UNIV ILLINOIS, DEPT ELECT & COMP ENGN, COMP & SYST RES LAB, 1308 W MAIN ST, URBANA, IL 61801 USA. RI White, Michael/B-3612-2009 OI White, Michael/0000-0001-8450-9135 NR 26 TC 11 Z9 11 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD FEB PY 1996 VL 99 IS 2 BP 755 EP 760 DI 10.1121/1.414652 PG 6 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA TU680 UT WOS:A1996TU68000013 ER PT J AU Robertson, JS Schlatter, PJ Siegmann, WL AF Robertson, JS Schlatter, PJ Siegmann, WL TI Sound propagation over impedance discontinuities with the parabolic approximation SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID ACOUSTIC PROPAGATION; BOUNDARIES; NOISE AB Long-range, low-frequency sound propagation over varying terrain conditions is an important problem with both civilian and military applications. This work, considers the modeling of cw acoustic signals as they propagate over variable-impedance topography. The NASA implicit finite-difference (NIFD) implementation of the parabolic approximation sound propagation model that incorporates variable-impedance ground surfaces was used. The accuracy of this numerical model is demonstrated with a pair of test problems. An application of the results is used to predict excess attenuation of pure-tone signals whose propagation path includes portions of a flat lake surface. (C) 1996 Acoustical Society of America. C1 US MIL ACAD,DEPT MATH SCI,W POINT,NY 10996. RENSSELAER POLYTECH INST,DEPT MATH SCI,TROY,NY 12180. RP Robertson, JS (reprint author), GEORGIA COLL,DEPT MATH & COMP SCI,MILLEDGEVILLE,GA 31061, USA. NR 20 TC 8 Z9 8 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD FEB PY 1996 VL 99 IS 2 BP 761 EP 767 DI 10.1121/1.414653 PG 7 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA TU680 UT WOS:A1996TU68000014 ER PT J AU Li, YL White, MJ AF Li, YL White, MJ TI A new fast field program for a multiple-source system SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Letter ID SOUND-PROPAGATION; ATMOSPHERE; TRANSFORM AB A new fast field program (FFP) has been developed for numerical computation of sound pressure from a phased multiple-source or multiple-receiver system in a layered atmosphere. The new FFP is based on a far-field approximation for which a criterion of validity is given. Using the stationary phase method, the twofold integral for sound pressure is reduced to a onefold integral representing the far-field approximation of sound pressure. The onefold integral makes the new FFP very efficient. (C) 1996 Acoustical Society of America. C1 USA,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL 61826. RP Li, YL (reprint author), UNIV ILLINOIS,DEPT ELECT & COMP ENGN,COMP & SYST RES LAB,1308 W MAIN ST,URBANA,IL 61801, USA. RI White, Michael/B-3612-2009 OI White, Michael/0000-0001-8450-9135 NR 14 TC 1 Z9 1 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD FEB PY 1996 VL 99 IS 2 BP 1252 EP 1254 DI 10.1121/1.414636 PG 3 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA TU680 UT WOS:A1996TU68000068 ER PT J AU Montemarano, AD Hengge, M Sau, P Welch, M AF Montemarano, AD Hengge, M Sau, P Welch, M TI Confluent and reticulated papillomatosis: Response to minocycline SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID SELENIUM SULFIDE; GOUGEROT; CARTEAUD AB Background: Confluent and reticulated papillomatosis (CRP) of Gougerot and Carteaud is an uncommon disorder of unknown cause for which a variety of treatments have been proposed. Objective: We attempted to evaluate the effectiveness of oral minocycline. Methods: Nine patients with CRP were treated with oral minocycline, 50 mg twice a day, for 6 weeks. The average follow-up period was 11 months. Recurrence rate, side effects, and effectiveness of therapy were assessed. Results: All patients except two had a 90% to 100% response to therapy. Recurrences were noted in three patients, all of whom responded to re-treatment with minocycline. None of the nine patients had an adverse reaction. Conclusion: Minocycline, 50 mg twice a day, is safe and effective for CRP. C1 95TH COMBAT SUPPORT HOSP,DERMATOL SERV,HEIDELBERG,GERMANY. RP Montemarano, AD (reprint author), WALTER REED ARMY MED CTR,DEPT DERMATOL,WASHINGTON,DC 20307, USA. NR 18 TC 33 Z9 33 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD FEB PY 1996 VL 34 IS 2 BP 253 EP 256 DI 10.1016/S0190-9622(96)80120-4 PN 1 PG 4 WC Dermatology SC Dermatology GA TV697 UT WOS:A1996TV69700011 PM 8642090 ER PT J AU Young, PC Montemarano, AD Lee, N Sau, P Weiss, RB James, WD AF Young, PC Montemarano, AD Lee, N Sau, P Weiss, RB James, WD TI Hypersensitivity to paclitaxel manifested as a bullous fixed drug eruption SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID HISTAMINE-RELEASE C1 WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,SECT MED ONCOL,WASHINGTON,DC. RP Young, PC (reprint author), DEWITT ARMY COMMUNITY HOSP,DEPT EMERGENCY MED,FT BELVOIR,VA, USA. NR 8 TC 21 Z9 21 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD FEB PY 1996 VL 34 IS 2 BP 313 EP 314 DI 10.1016/S0190-9622(96)80147-2 PN 1 PG 2 WC Dermatology SC Dermatology GA TV697 UT WOS:A1996TV69700027 PM 8642105 ER PT J AU Pereyo, NG Heimer, WL AF Pereyo, NG Heimer, WL TI Extraabdominal desmoid tumor SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID GARDNERS-SYNDROME; BENIGN DISEASE; MANAGEMENT; RADIOTHERAPY; EXPERIENCE; TAMOXIFEN AB An extraabdominal desmoid tumor of the shoulder occurring in a middle-aged woman without Gardner's syndrome is described. Two punch biopsy specimens from the tumor were initially interpreted as representing scar tissue; a third incisional biopsy specimen demonstrated the characteristic features of a desmoid tumor. Because desmoid tumors are locally aggressive, early diagnosis and treatment are crucial to minimize morbidity and mortality. Typical clinical and histologic findings characteristic of an extraabdominal desmoid tumor are described, and treatment options are reviewed. C1 EISENHOWER ARMY MED CTR,DEPT MED,DERMATOL SERV,FT GORDON,GA. RP Pereyo, NG (reprint author), MED COLL GEORGIA,DEPT MED,DERMATOL SECT,AUGUSTA,GA 30912, USA. NR 37 TC 11 Z9 11 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD FEB PY 1996 VL 34 IS 2 BP 352 EP 356 DI 10.1016/S0190-9622(07)80007-7 PN 2 PG 5 WC Dermatology SC Dermatology GA TX999 UT WOS:A1996TX99900006 PM 8655725 ER PT J AU Welch, PG Fattom, A Moore, J Schneerson, R Shiloach, J Bryla, DA Li, XR Robbins, JB AF Welch, PG Fattom, A Moore, J Schneerson, R Shiloach, J Bryla, DA Li, XR Robbins, JB TI Safety and immunogenicity of Staphylococcus aureus type 5 capsular polysaccharide-Pseudomonas aeruginosa recombinant exoprotein A conjugate vaccine in patients on hemodialysis SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Article DE end-stage renal disease; Staphylococcus aureus vaccine; antibody response; conjugate vaccine ID INFLUENZAE TYPE-B; AMBULATORY PERITONEAL-DIALYSIS; SERUM ANTIBODY-RESPONSE; EXOTOXIN-A; NASAL CARRIAGE; BACTEREMIA; INFECTION; PREDOMINANCE; PHAGOCYTOSIS; SEPTICEMIA AB Seventeen volunteers with ESRD on hemodialysis, negative for infection with HIV or hepatitis B and C and not receiving immunosuppressive therapy, were injected two times 6 wk apart with 25 mu g of Staphylococcus aureus Type 5 capsular polysaccharide-Pseudomonos aeruginosa exoprotein A (rEPA) conjugate, Controls were healthy adults, 18 to 44 yr old, injected previously with the same vaccine. None of the patients had fever or significant elevations in their SGOT or SGPT attributable to the vaccine, Two vaccinees had transient induration >1 cm in diameter at the injection site, The preimmunization geometric mean (GM) Type 5 antibody levels of the ESRD patients and controls were similar, Type 5 antibody levels of the three major immunoglobulin (Ig) classes rose at 2 and 6 wk after immunization (P < 0.001 for IgG, P < 0.005 for IgM, and P = 0.0001 for IgA), Reimmunization at 6 wk did not elicit a booster response, At 6 months, the GM IgG level of the patients was approximately 50% of that of the healthy volunteers and 14 of 17 had a more than fourfold higher antibody level than the preimmune value, The GM IgM level, in contrast, declined to the preimmunization value. Vaccine-induced Type 5 antibodies had opsonophagocytic activity, There was a slight increase of IgG antibodies to the heterologous S. aureus Type 8 polysaccharide (P < 0.01) that was sustained at 6 months. The S. aureus Type 5-rEPA vaccine is safe and immunogenic in ESRD patients, and evaluation of its effectiveness against S. aureus bacteremia in this at-risk group is planned. C1 NICHHD,PUBL HLTH SERV,NIH,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,SERV NEPHROL,WASHINGTON,DC 20307. UNIVAX BIOL INC,ROCKVILLE,MD. NIDDKD,NIH,BETHESDA,MD 20892. NR 52 TC 38 Z9 40 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1046-6673 J9 J AM SOC NEPHROL JI J. Am. Soc. Nephrol. PD FEB PY 1996 VL 7 IS 2 BP 247 EP 253 PG 7 WC Urology & Nephrology SC Urology & Nephrology GA TZ306 UT WOS:A1996TZ30600010 PM 8785394 ER PT J AU Fradkin, JM AF Fradkin, JM TI Lessons learned from conducting humanitarian assistance missions SO JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION LA English DT Letter RP Fradkin, JM (reprint author), USA,SAN DIEGO,CA, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER VETERINARY MEDICAL ASSOC PI SCHAUMBURG PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 SN 0003-1488 J9 J AM VET MED ASSOC JI J. Am. Vet. Med. Assoc. PD FEB 1 PY 1996 VL 208 IS 3 BP 337 EP 338 PG 2 WC Veterinary Sciences SC Veterinary Sciences GA TR347 UT WOS:A1996TR34700008 ER PT J AU Ommaya, AK Ommaya, AK Dannenberg, AL Salazar, AM AF Ommaya, AK Ommaya, AK Dannenberg, AL Salazar, AM TI Causation, incidence, and costs of traumatic brain injury in the US military medical system SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE head injury; epidemiology; costs; causes ID CARE AB Hospital discharge records from military facilities and private facilities reimbursed by Civilian Health and Medical Program of the Uniformed Services for fiscal year 1992 were reviewed to identify head injury admissions. Incidence rates, case fatality rates, causes of head injuries, and direct cost for hospital admissions were computed in this well-defined population. For fiscal year 1992, there were 5,568 hospitalized cases of noncombat head injury in the military medical system. The age-adjusted head injury rates for ages 15-44 years are higher in active-duty individuals compared with other beneficiaries (1.6 times greater for men and 2.5 times greater for women). The total cost for hospitalization in this population was $43 million. Private facility rehabilitation accounted for 26% of all private facility costs but only 6% of head injury cases. Firearms and motor vehicle crashes caused the most severe injuries for cases admitted to military facilities. Motor vehicle crashes, falls, and fighting accounted for 80% of the total military facility cost for head injuries, Military active-duty individuals are at increased risk for noncombat head injury. Prevention of head injury in military settings should focus on motor vehicle crashes, fist fights (assault), and falls. C1 GEORGE WASHINGTON UNIV,DEPT NEUROSURG,WASHINGTON,DC. JOHNS HOPKINS UNIV,SCH PUBL HLTH,INJURY PREVENT CTR,BALTIMORE,MD. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP Ommaya, AK (reprint author), WALTER REED ARMY MED CTR,DEF & VET HEAD INJURY PROGRAM,BLDG 7,ROOM 240,WASHINGTON,DC 20307, USA. FU AHRQ HHS [R03 HS08414-01] NR 16 TC 50 Z9 50 U1 0 U2 5 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD FEB PY 1996 VL 40 IS 2 BP 211 EP 217 DI 10.1097/00005373-199602000-00007 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA TW081 UT WOS:A1996TW08100007 PM 8637068 ER PT J AU Rozanski, TA Wojno, KJ Bloom, DA AF Rozanski, TA Wojno, KJ Bloom, DA TI The remnant orchiectomy SO JOURNAL OF UROLOGY LA English DT Article DE testis; cryptorchism ID TESTES; CRYPTORCHIDISM; LAPAROSCOPY; MONORCHISM; HISTOLOGY AB Purpose: We examined and characterized the histological features of remnant testicular tissue distal to the internal inguinal ring in boys who underwent exploration for a nonpalpable testis. Materials and Methods: The medical records and histology of 48 boys (50 remnants) who underwent exploration for a nonpalpable testis during a 10-year period were reviewed in detail. Results: Remnant tissue was characterized by evidence of ischemia and necrosis (scar, calcification, hemosiderin and hyalinization) suggestive of a vascular accident. Viable germ cells were identified in 5 remnants. Conclusions: A 10% incidence of viable germ cells in remnant testicular tissue warrants exploration and removal of all remnant tissue in boys who undergo exploration for a nonpalpable testis. C1 UNIV MICHIGAN,DEPT PATHOL,ANN ARBOR,MI 48109. UNIV MICHIGAN,DEPT SURG,UROL SECT,ANN ARBOR,MI 48109. RP Rozanski, TA (reprint author), BROOKE ARMY MED CTR,DEPT SURG,UROL SERV,SAN ANTONIO,TX, USA. NR 17 TC 28 Z9 28 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD FEB PY 1996 VL 155 IS 2 BP 712 EP 713 DI 10.1016/S0022-5347(01)66507-8 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA TP493 UT WOS:A1996TP49300099 PM 8558712 ER PT J AU Bowersox, JC Shah, A Jensen, J Hill, J Cordts, PR Green, PS AF Bowersox, JC Shah, A Jensen, J Hill, J Cordts, PR Green, PS TI Vascular applications of telepresence surgery: Initial feasibility studies in swine SO JOURNAL OF VASCULAR SURGERY LA English DT Article; Proceedings Paper CT 49th Annual Meeting of the Society-for-Vascular-Surgery CY JUN 11-12, 1995 CL NEW ORLEANS, LA SP Soc Vasc Surg AB Purpose: Telepresence surgery is a novel technology that will allow procedures to be performed on a patient at locations that are physically remote from the operating surgeon. This new method provides the sensory illusion that the surgeon's hands are in direct contact with the patient. We studied the feasibility of the use of telepresence surgery to perform basic operations in vascular surgery, including tissue dissection, vessel manipulation, and suturing. Methods: A prototype telepresence surgery system with bimanual force-reflective manipulators, interchangeable surgical instruments, and stereoscopic video input was used. Arteriotomies created ex vivo in segments of bovine aortae or in vivo in femoral arteries of anesthetized swine were closed with telepresence surgery or by conventional techniques. Time required, technical quality (patency, integrity of suture line), and subjective difficulty were compared for the two methods. Results: All attempted procedures were successfully completed with telepresence surgery. Arteriotomy closures were completed in 192 +/- 24 sec with conventional techniques and 483 +/- 118 sec with telepresence surgery, but the precision attained with telepresence surgery was equal to that of conventional techniques. Telepresence surgery was described as intuitive and natural by the surgeons who used the system. Conclusions: Blood-vessel manipulation and suturing with telepresence surgery are feasible. Further instrument development (to increase degrees of freedom) is required to achieve operating times comparable to conventional open surgery, but the system has great potential to extend the expertise of vascular surgeons to locations where specialty care is currently unavailable. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. SRI INT INC,MED TECHNOL LAB,MENLO PK,CA. TRIPLER ARMY MED CTR,DEPT SURG,HONOLULU,HI 96859. FU NIGMS NIH HHS [GM 44902] NR 21 TC 60 Z9 60 U1 0 U2 2 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD FEB PY 1996 VL 23 IS 2 BP 281 EP 286 DI 10.1016/S0741-5214(96)70272-0 PG 6 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA TW977 UT WOS:A1996TW97700020 PM 8637105 ER PT J AU Richardson, TM Stryjewski, BL Broder, CC Hoxie, JA Mascola, JR Earl, PL Doms, RW AF Richardson, TM Stryjewski, BL Broder, CC Hoxie, JA Mascola, JR Earl, PL Doms, RW TI Humoral response to oligomeric human immunodeficiency virus type 1 envelope protein SO JOURNAL OF VIROLOGY LA English DT Article ID HUMAN MONOCLONAL-ANTIBODY; CD4 BINDING-SITE; GLYCOPROTEIN GP120; HTLV-III; TRANSMEMBRANE GLYCOPROTEIN; SURFACE GLYCOPROTEIN; CD4-BINDING SITE; HIV-1; NEUTRALIZATION; GP41 AB The humoral immune response to human immunodeficiency virus type 1 (HIV-1) is often studied by using monomeric or denatured envelope proteins (Env), However, native HIV-1 Env complexes that maintain quaternary structure elicit immune responses that are qualitatively distinct from those seen with monomeric or denatured Env, To more accurately assess the levels and types of antibodies elicited by HIV-1 infection, we developed an antigen capture enzyme-linked immunosorbent assay using a soluble, oligomeric form of HIV-1(IIIB) Env (gp140) that contains gp120 and the gp41 ectodomain. The gp140, captured by various monoclonal antibodies (MAbs), retained its native oligomeric structure: it bound CD4 and was recognized by MAbs to conformational epitopes in gp120 and gp41, including oligomer-specific epitopes in gp41, We compared the reactivities of clade B and clade E serum samples to captured Env preparations and found that while both reacted equally well with oligomeric gp140, clade B seras reacted more strongly with monomeric gp120 than did clade E samples, However, these differences were minimized when gp120 was captured by a V3 loop MAb, which may lead to increased exposure of the CD4 binding site, We also measured the ability of serum samples to block binding of MAbs to epitopes in gp120 and gp41, Clade B serum samples consistently blocked binding of oligomer-dependent MAbs to gp41 and, to a slightly lesser extent, MAbs to the CD4 binding site in gp120, Clade E serum samples showed equivalent or greater blocking of oligomer-dependent gp41 antibodies and considerably less blocking of CD4-binding-site MAbs, Finally, we found that <5% of the antibodies in clade B sera bound to epitopes present only in monomeric gp120, 30% bound to epitopes present in both monomeric gp120 and oligomeric gp140, and 70% bound to epitopes present in oligomeric gp140, which includes gp41. Thus, captured oligomeric Env closely reflects the antigenic characteristics of Env protein on the surface of virions and infected cells, retains highly conserved epitopes that are recognized by antibodies raised against different clades, and makes it possible to detect a much greater fraction of total anti-HIV-1 Env activity in sera than does native monomeric gp120. C1 UNIV PENN,DEPT PATHOL & LAB MED,PHILADELPHIA,PA 19104. UNIV PENN,DEPT MED HEMATOL ONCOL,PHILADELPHIA,PA 19104. NIAID,VIRAL DIS LAB,BETHESDA,MD 20892. WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD 20850. FU NIAID NIH HHS [R01 AI35383] NR 60 TC 72 Z9 72 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD FEB PY 1996 VL 70 IS 2 BP 753 EP 762 PG 10 WC Virology SC Virology GA TP526 UT WOS:A1996TP52600010 PM 8551612 ER PT J AU Colgin, LMA Moeller, RB AF Colgin, LMA Moeller, RB TI Benign cutaneous mast cell tumor in a rhesus monkey SO LABORATORY ANIMAL SCIENCE LA English DT Article RP Colgin, LMA (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21005, USA. NR 12 TC 4 Z9 4 U1 0 U2 1 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI CORDOVA PA 70 TIMBERCREEK DR, SUITE 5, CORDOVA, TN 38018 SN 0023-6764 J9 LAB ANIM SCI JI Lab. Anim. Sci. PD FEB PY 1996 VL 46 IS 1 BP 123 EP 124 PG 2 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA TW872 UT WOS:A1996TW87200030 PM 8699810 ER PT J AU Kragh, JF Taylor, DC AF Kragh, JF Taylor, DC TI Parachuting injuries: A medical analysis of an airborne operation SO MILITARY MEDICINE LA English DT Article ID LANDING INJURIES AB The purpose of this paper is to discuss parachuting variables as they affect support and planning, The authors retrospectively analyzed an operation in which a Ranger battalion parachuted onto an airfield drop zone. Leaders weighed Rangers to estimate the soldiers' load. The advance team failed to adequately coordinate administrative medical assistance on the drop zone, Forty-one Rangers were injured and evacuated from the drop zone (8.6% of the jumpers), Variables in such operations include drop zone selection, equipment weight, drop altitude, wind speed, the wind-flight angle, drop height, and jumper density over the drop zone. Solutions include cargo drops and leaders' repeated emphasis on minimizing the soldiers' loads in accordance with mission accomplishment. RP Kragh, JF (reprint author), EISENHOWER ARMY MED CTR,DEPT SURG,ORTHOPAED DIV,FT GORDON,GA 30905, USA. NR 22 TC 10 Z9 10 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD FEB PY 1996 VL 161 IS 2 BP 67 EP 69 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA TU800 UT WOS:A1996TU80000006 PM 8857215 ER PT J AU Powell, AJ Rumph, JW Lyons, MK Finstuen, K AF Powell, AJ Rumph, JW Lyons, MK Finstuen, K TI Health risk appraisal and serum cholesterol nutrition education: An outcome study SO MILITARY MEDICINE LA English DT Article ID CORONARY HEART-DISEASE; DENSITY LIPOPROTEIN; LIPID MEASUREMENTS; DIET; PROGRAM; CENTERS; PLASMA AB Records of 59 U.S. Army service members identified as at-risk for coronary heart disease were reviewed. Soldiers were divided into groups that completed and did not complete cholesterol nutrition education classes, Differences in the means of repeated cholesterol measures were compared within each group, Results showed statistically significant declines in total cholesterol, with t(35) = 2.94, p < 0.01 for the class completion group and t(22) = 2.18, p < 0.05 for the dropout group. Similar results were noted for low-density lipoprotein measures, However, cholesterol differences in the means between the two groups were not statistically significant. Results indicate that decreases in serum cholesterol may occur due to at-risk reactive behavior, but that full compliance with the current nutrition education program does not appear to further reduce cholesterol levels to any appreciable degree. RP Powell, AJ (reprint author), BAYLOR UNIV,USA,GRAD PROGRAM HLTH CARE ADM,FT SAM HOUSTON,TX 78234, USA. NR 24 TC 1 Z9 1 U1 1 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD FEB PY 1996 VL 161 IS 2 BP 70 EP 74 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA TU800 UT WOS:A1996TU80000007 PM 8857216 ER PT J AU Davis, MK AF Davis, MK TI A comprehensive weight-loss program for soldiers SO MILITARY MEDICINE LA English DT Article ID REDUCTION PROGRAM; EATING DISORDERS; FAT AB A weight-loss treatment program for active duty military personnel is discussed and evaluated. The Fat Loss and Exercise Program at U.S. Army Hospital, Bremerhaven, Germany, consisted of a 3-week inpatient treatment program and 6 months of weekly outpatient follow-up. The program combined a multidisciplinary team approach to the treatment of obesity-psychology, internal medicine, nursing, nutrition care, and physical therapy. Patients showed a significant weight and body fat loss [F(2,90) = 52.91 and 65.85, p < 0.001, respectively] from the initiation of treatment (mean = 205.9 pounds, 28.91%) to the end of the inpatient program [mean = 192.8 pounds, 25.97%] with maintenance over 6 months (mean = 190.4 pounds, 25.03%). Changes in cholesterol levels by treatment phase are also discussed. Results demonstrate positive increases in high-density lipoprotein at each phase. These results support a comprehensive, multidisciplinary inpatient treatment of obesity within the military. RP Davis, MK (reprint author), USA,CTR HLTH PROMOT & PREVENT MED,HLTH PROMOT & WELLNESS DIRECTORATE,PERSONAL READINESS DIV,ABERDEEN PROVING GROUND,MD 21010, USA. NR 24 TC 18 Z9 18 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD FEB PY 1996 VL 161 IS 2 BP 84 EP 88 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA TU800 UT WOS:A1996TU80000010 PM 8857219 ER PT J AU James, LC Kowalski, TJ AF James, LC Kowalski, TJ TI Suicide prevention in an army infantry division: A multi-disciplinary program SO MILITARY MEDICINE LA English DT Article ID UNITED-STATES-ARMY AB This article is intended to provide an overview of the 25th Infantry Division (Light) Suicide Prevention Program, A multidisciplinary intervention model, it outlines the role of chaplains and division mental health officers as well as indicators or warning signs relevant to army personnel who have committed suicide, Prevention strategies applicable to the military community, including Crisis Intervention Command Consultations, will be recommended, It is hoped that this information will not only assist professionals in identifying personnel at risk for suicide, but aid in the development of other suicide prevention programs. RP James, LC (reprint author), TRIPLER ARMY MED CTR,PSYCHOL SERV,HONOLULU,HI 96859, USA. NR 11 TC 13 Z9 13 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD FEB PY 1996 VL 161 IS 2 BP 97 EP 101 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA TU800 UT WOS:A1996TU80000013 PM 8857222 ER PT J AU Brown, AE Tomlinson, JP Brundage, JF Burke, DS AF Brown, AE Tomlinson, JP Brundage, JF Burke, DS TI The US Army HIV testing program: The first decade SO MILITARY MEDICINE LA English DT Article ID IMMUNODEFICIENCY-VIRUS-INFECTIONS; UNITED-STATES MILITARY; LABORATORY DIAGNOSIS; WESTERN BLOT; HTLV-III; AIDS; RISK; DUTY; APPLICANTS; DEFENSE AB In response to the human immunodeficiency virus (HIV) epidemic, the U.S. military established comprehensive policies to protect individual and public health and to assure military readiness. Central to this effort was the creation of a total-force HIV screening program. As representative of these military programs, the U.S. Army's HIV testing program is described, The first decade of this-program is assessed from financial, research, policy, and epidemic-control perspectives, We conclude that the government's investment has been a prudent one, leaving the U,S, military better positioned to counter the threats posed by the HIV pandemic. RP Brown, AE (reprint author), WALTER REED ARMY MED CTR,DIV RETROVIROL,ROCKVILLE,MD 20850, USA. OI /0000-0002-5704-8094 NR 40 TC 21 Z9 22 U1 1 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD FEB PY 1996 VL 161 IS 2 BP 117 EP 122 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA TU800 UT WOS:A1996TU80000018 PM 8857227 ER PT J AU Brown, AE Jackson, JN Newby, JH Burke, DS Ray, KL AF Brown, AE Jackson, JN Newby, JH Burke, DS Ray, KL TI Prevention and treatment of HIV infections in minorities in the US military: A review of military research SO MILITARY MEDICINE LA English DT Editorial Material ID IMMUNODEFICIENCY-VIRUS INFECTION; STAGE; DISEASE RP Brown, AE (reprint author), WALTER REED ARMY MED CTR,DIV RETROVIROL,ROCKVILLE,MD 20850, USA. OI /0000-0002-5704-8094 NR 17 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD FEB PY 1996 VL 161 IS 2 BP 123 EP 127 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA TU800 UT WOS:A1996TU80000019 PM 8857228 ER PT J AU Lowry, MA McEvoy, PL Ownbey, JL AF Lowry, MA McEvoy, PL Ownbey, JL TI A case of tungiasis SO MILITARY MEDICINE LA English DT Article ID TUNGA-PENETRANS AB Tunga penetrans is a burrowing nea that is prevalent in Central and South America, the Caribbean, tropical Africa, India, and Pakistan, and rarely is imported to the United States, Tungiasis results from the cutaneous infestation of humans by the gravid female nea, T. penetrans. We report a case of tungiasis in a female who had been on a missionary expedition along the Brazilian Amazon River. The clinical presentation, life cycle, differential diagnosis, military and historical aspects, and treatment are discussed. RP Lowry, MA (reprint author), WOMACH ARMY MED CTR,DEPT PATHOL,FT BRAGG,NC 28307, USA. NR 11 TC 8 Z9 8 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD FEB PY 1996 VL 161 IS 2 BP 128 EP 129 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA TU800 UT WOS:A1996TU80000020 PM 8857229 ER PT J AU Satava, RM Jones, SB AF Satava, RM Jones, SB TI Virtual reality, telepresence surgery and advanced surgical technologies SO MINIMALLY INVASIVE THERAPY & ALLIED TECHNOLOGIES LA English DT Editorial Material C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 1 Z9 1 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0961-625X J9 MINIM INVASIV THER JI Minim. Invasive Ther. Allied Technol. PD FEB PY 1996 VL 5 IS 1 BP 2 EP 4 DI 10.3109/13645709609153272 PG 3 WC Surgery SC Surgery GA UR602 UT WOS:A1996UR60200002 ER PT J AU Yancey, NK Duff, P Kubilis, P Clark, P Frentzen, BH AF Yancey, NK Duff, P Kubilis, P Clark, P Frentzen, BH TI Risk factors for neonatal sepsis SO OBSTETRICS AND GYNECOLOGY LA English DT Article ID B STREPTOCOCCAL COLONIZATION; INTRA-AMNIOTIC INFECTION; INTRAAMNIOTIC INFECTION; LABOR; MANAGEMENT; DISEASE; TRIAL; TERM AB Objective: To determine the associations between maternal characteristics, intrapartum events, and neonatal sepsis by multivariate analysis. Methods: We enrolled 823 women from a high-risk population and analyzed maternal and neonatal demographic and outcome variables with univariate analysis and multivariate logistic modeling. Results: Two-hundred sixteen women (26%) were colonized with group B streptococci, 82 (10%) developed chorioamnionitis, and 141 (17%) delivered prematurely. Culture-proven neonatal sepsis or meningitis was found in 15 of 833 (1.8%) neonates, and 101 of the remaining 818 (12.3%) infants were suspected to have sepsis or pneumonia. Multivariate analysis of risk factors for proven neonatal sepsis demonstrated a statistically significant association with decreasing gestational age, duration of internal monitoring for more than 12 hours (odds ratio [OR] 7.2, 95% confidence interval [CI] 1.6-32.2), maternal group B streptococcal infection (OR 4.2, 95% CI 1.4-13.1), chorioamnionitis (OR 4.4, 95% CI 1.2-16.1), and endometritis (OR 6.4, 95% CI 1.2-34.2). Conclusion: Through the use of multivariate modeling, we determined that chorioamnionitis or endometritis, preterm delivery, group B streptococcal colonization, and a prolonged duration of internal monitoring are independent risk factors for neonatal sepsis. We postulate that the presence of a foreign body that traverses the birth canal may facilitate ascending peripartal infection. C1 UNIV FLORIDA,COLL MED,DEPT OBSTET & GYNECOL,GAINESVILLE,FL. UNIV FLORIDA,COLL MED,DEPT BIOSTAT,GAINESVILLE,FL. RP Yancey, NK (reprint author), TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,HONOLULU,HI 96859, USA. NR 25 TC 5 Z9 7 U1 1 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD FEB PY 1996 VL 87 IS 2 BP 188 EP 194 PG 7 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA TR530 UT WOS:A1996TR53000006 ER PT J AU Finnegan, TP Macmillan, AHM Miller, SAS Richardson, JC AF Finnegan, TP Macmillan, AHM Miller, SAS Richardson, JC TI Occupational medicine: The way ahead SO OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Letter C1 USA MED DIRECTORATE,WASHINGTON,DC. USA,OCCUPAT HLTH RES UNIT,WASHINGTON,DC. NR 2 TC 0 Z9 0 U1 0 U2 0 PU BRITISH MED JOURNAL PUBL GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON, ENGLAND WC1H 9JR SN 1351-0711 J9 OCCUP ENVIRON MED JI Occup. Environ. Med. PD FEB PY 1996 VL 53 IS 2 BP 142 EP 143 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA TU100 UT WOS:A1996TU10000013 PM 8777452 ER PT J AU Manasson, VA Sadovnik, LS Shnitser, PI Mino, R Kruger, JS AF Manasson, VA Sadovnik, LS Shnitser, PI Mino, R Kruger, JS TI Millimeter-wave optically scanning antenna based on photoinduced plasma grating SO OPTICAL ENGINEERING LA English DT Article DE millimeter waves; scanning antennas; photogenerated plasma; semiconductors AB The photocontrolled millimeter-wave (MMW) antenna is an alternative approach to the phased array. it offers a high potential to decrease fabrication cost. We describe a new MMW scanning antenna controlled by light. The basic antenna element is a semiconductor plate containing a photoinduced plasma grating (PIPG). By changing the grating period and rotating the grating, the device is able to scan a MMW beam in two dimensions. To enhance antenna efficiency, we use an antenna design that takes advantage of the reflectance of the MMW mirror behind the semiconductor plate. We found that the pulse duration of the pumping light can strongly affect the antenna's output. Our calculations demonstrate that diffusion is responsible for decay of antenna efficiency. (C) 1996 Society of Photo-Optical Instrumentation Engineers. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP Manasson, VA (reprint author), PHYS OPT CORP,DEPT RES & DEV,20600 GRAMERCY PL,BLDG 100,TORRANCE,CA 90501, USA. OI Manasson, Vladimir A./0000-0001-6234-8086 NR 10 TC 14 Z9 14 U1 0 U2 3 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD FEB PY 1996 VL 35 IS 2 BP 357 EP 361 DI 10.1117/1.600904 PG 5 WC Optics SC Optics GA TV854 UT WOS:A1996TV85400007 ER PT J AU Gu, ZH Josse, M Ciftan, M AF Gu, ZH Josse, M Ciftan, M TI Observation of giant enhanced backscattering of light from weakly rough dielectric films on reflecting metal substrates SO OPTICAL ENGINEERING LA English DT Article DE enhanced backscattering; wave scattering; opposition effect; localization; thin films; physical optics; lidar and remote sensing ID RANDOM SURFACES; SCATTERING; DEPOLARIZATION AB The enhanced backscattering of light from a randomly rough surface, which is manifested as a narrow peak in the retroreflection direction in the angular distribution of the intensity of the light that is scattered diffusely, has been extensively studied. Both theoretical and experimental investigations have shown that the height of the peak is never more than twice the height of the background at the position of the peak. We report the observation of a giant enhanced backscattering of light from a randomly weak rough dielectric film on a reflecting metal substrate, in which the ratio of the height of the peak to the height of the background at its position is greater than 10. It is found that this giant enhanced backscattering peak is accompanied by concentric circular interference fringes, whose axis is normal to the mean scattering surface, with both the specular and backscattering peak on the same ring. A possible mechanism for the giant backscattering is suggested. (C) 1996 Society of Photo-Optical Instrumentation Engineers. C1 CEA, CESTA, F-33114 LE BARP, FRANCE. USA, RES OFF, RES TRIANGLE PK, NC 27709 USA. RP Gu, ZH (reprint author), SURFACE OPT CORP, POB 261602, SAN DIEGO, CA 92196 USA. NR 18 TC 9 Z9 9 U1 0 U2 0 PU SPIE-SOC PHOTOPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD FEB PY 1996 VL 35 IS 2 BP 370 EP 375 DI 10.1117/1.600906 PG 6 WC Optics SC Optics GA TV854 UT WOS:A1996TV85400009 ER PT J AU Kant, GJ Wylie, RM Vasilakis, AA Ghosh, S AF Kant, GJ Wylie, RM Vasilakis, AA Ghosh, S TI Effects of triazolam and diazepam on learning and memory as assessed using a water maze SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR LA English DT Article DE triazolam; diazepam; Halcion; Valium; learning; memory; water maze; performance ID PERFORMANCE; ACQUISITION; SLEEP; BENZODIAZEPINES; IMPAIRMENT; DEFICITS; DRUGS; RAT AB One of the reported adverse side effects of the frequently prescribed benzodiazepines diazepam (Valium(R)) and triazolam (Halcion(R)) is an impairment of anterograde memory in humans. The experiments described in this article compared the effects of triazolam and diazepam on performance in a water maze task that is sensitive to drugs that affect learning and memory. The water maze utilized is a traditional type of maze with alleyways and door choices, unlike the Morris open water maze. Time required to find an out-of-the-water platform and errors committed during the swim are used as performance measures. Rats were tested on a previously learned maze configuration and on the acquisition of new maze configurations. Neither diazepam (0.25, 1.0, or 2.0 mg/kg) nor triazolam (0.05, 0.2, or 0.3 mg/kg) injected 30 min prior to testing on the previously learned maze affected swim time or errors committed. Administration of diazepam (0.5, 1.0, or 2.0 mg/kg, IP) prior to daily training on three different new maze configurations did not affect swim time, but did increase swim errors. Triazolam administered at 0.1, 0.2, or 0.3 mg/kg markedly impaired performance as assessed by either swim time or errors. There were no differences in performance of rats previously treated with triazolam, diazepam, or vehicle in learning another new maze after drug treatment was terminated. These data demonstrate that both diazepam and triazolam affect acquisition but not recall of maze configurations and support similar conclusions reached using other types of tasks in humans and animals. RP Kant, GJ (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV NEUROSCI,WASHINGTON,DC 20307, USA. NR 20 TC 22 Z9 25 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0091-3057 J9 PHARMACOL BIOCHEM BE JI Pharmacol. Biochem. Behav. PD FEB PY 1996 VL 53 IS 2 BP 317 EP 322 DI 10.1016/0091-3057(95)02028-4 PG 6 WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy GA TT772 UT WOS:A1996TT77200013 PM 8808138 ER PT J AU Kant, GJ Meininger, GR Maughan, KR Wright, WL Robinson, TN Neely, TM AF Kant, GJ Meininger, GR Maughan, KR Wright, WL Robinson, TN Neely, TM TI Effects of the serotonin receptor agonists 8-OH-DPAT and TFMPP on learning as assessed using a novel water maze SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR LA English DT Article DE serotonin agonists; water maze; learning; memory; rat; 8-OH-DPAT; TFMPP; 5-HT1A receptor; 5-HT2C receptor ID LOCOMOTOR-ACTIVITY; 5-HT1A RECEPTORS; RAT; MEMORY; PERFORMANCE; 8-HYDROXY-2-(DI-NORMAL-PROPYLAMINO)TETRALIN; SUBTYPES; BLOCKADE; DRUGS AB We evaluated the effects of two drugs active at serotonin receptors, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT, a 5-HT1A agonist) and N-3-trifluoromethylphenyl)piperazine hydrochloride (TFMPP, a 5-HT2C agonist) on learning using a novel water maze previously characterized in our laboratory. The water maze utilized is a traditional type of maze with alleyways and doors through which the rats learn to swim to reach a platform, unlike the open pool Morris water maze task. Performance is assessed by swim time required to reach the platform and errors committed. Following initial training on maze configuration A, rats were assigned to saline, TFMPP and 8-OH-DPAT treatment groups and tested for performance once per dose, 30 min after administration of drug (0.25. 0.5, and 1.0 mg/kg IP). Swim times were significantly increased as compared to saline for all doses for both drugs. The error rate was increased for 8-OH-DPAT at all doses, while TFMPP had no effect on error rate at any dose. Next, rats were challenged to learn new mazes following daily administration of 0.25 or 0.5 mg/kg of each drug 30 min prior to each daily swim trial. Rats given 0.25 mg/kg of 8-OH-DPAT learned new maze C more slowly than saline-treated rats, while TFMPP had no effect at this dose. At the higher dose of 0.5 mg/kg, tested on new maze B, TFMPP administration significantly increased swim times but not errors, while this dose of 8-OH-DPAT markedly increased both swim time and errors. Finally, rats from all groups were tested on maze E after drug administration was discontinued, and there were no performance differences among groups. These data suggest that serotonin(1A) receptors may inhibit learning. RP Kant, GJ (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV NEUROSCI,WASHINGTON,DC 20307, USA. NR 37 TC 23 Z9 23 U1 3 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0091-3057 J9 PHARMACOL BIOCHEM BE JI Pharmacol. Biochem. Behav. PD FEB PY 1996 VL 53 IS 2 BP 385 EP 390 DI 10.1016/0091-3057(95)02038-1 PG 6 WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy GA TT772 UT WOS:A1996TT77200023 PM 8808148 ER PT J AU Crenshaw, ME Bowden, CM AF Crenshaw, ME Bowden, CM TI Local-field effects in a dense collection of two-level atoms embedded in a dielectric medium: Intrinsic optical bistability enhancement and local cooperative effects SO PHYSICAL REVIEW A LA English DT Article ID RESONANCE; LASERS AB We investigate the effect of a linear host medium on the dynamics of a dense collection of resonant atoms. We find that near dipole-dipole interaction is enhanced by the presence of the host dielectric, resulting in a lower threshold density and a greater hysteresis area for intrinsic optical bistability. Cooperative decay terms appear that represent the interaction of near dipoles mediated by the absorptive component of the dielectric function of the host medium. These terms are part of the local response and correspond to local cooperative decay effects. RP USA, MISSILE COMMAND,CTR RES DEV & ENGN, WEAP SCI DIRECTORATE,AMSMI, RD, WS, REDSTONE ARSENAL, AL 35898 USA. NR 25 TC 52 Z9 52 U1 0 U2 2 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9926 EI 2469-9934 J9 PHYS REV A JI Phys. Rev. A PD FEB PY 1996 VL 53 IS 2 BP 1139 EP 1142 DI 10.1103/PhysRevA.53.1139 PG 4 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA TV648 UT WOS:A1996TV64800063 ER PT J AU Tolbert, D AF Tolbert, D TI Medical physics is a demanding profession SO PHYSICS TODAY LA English DT Letter RP Tolbert, D (reprint author), TRIPLER ARMY MED CTR,HONOLULU,HI 96859, USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0031-9228 J9 PHYS TODAY JI Phys. Today PD FEB PY 1996 VL 49 IS 2 BP 13 EP & DI 10.1063/1.2807495 PG 2 WC Physics, Multidisciplinary SC Physics GA TU620 UT WOS:A1996TU62000002 ER PT J AU Bates, P Mahadik, S Mukherjee, S Mahadik, J Correnti, E Scheffer, R AF Bates, P Mahadik, S Mukherjee, S Mahadik, J Correnti, E Scheffer, R TI Growth effects of a neuroprotective factor in schizophrenia and bipolar disorder SO SCHIZOPHRENIA RESEARCH LA English DT Meeting Abstract C1 GRIFFITH UNIV,NATHAN,QLD 4111,AUSTRALIA. MED COLL GEORGIA,AUGUSTA,GA 30912. DWIGHT DAVID EISENHOWER HOSP,FT GORDON,GA 30905. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0920-9964 J9 SCHIZOPHR RES JI Schizophr. Res. PD FEB PY 1996 VL 18 IS 2-3 BP VIII1 EP VIII1 PG 1 WC Psychiatry SC Psychiatry GA UE365 UT WOS:A1996UE36500180 ER PT J AU Straub, FK Merkley, DJ AF Straub, FK Merkley, DJ TI Design of a servo-flap rotor for reduced control loads SO SMART MATERIALS & STRUCTURES LA English DT Article AB The results of a study to conceptually define a servo-flap rotor with on-blade smart material actuators for primary and active control are presented. Selection of the flap and rotor design parameters is directed to minimize the control effort. Simulation results for an AH-64 size aircraft show that substantial reductions in control effort as well as main rotor power can be achieved through judicious selection of the rotor and flap design parameters and introduction of adaptive rotor features. C1 USA,AATD,FT EUSTIC,VA. MCDONNELL DOUGLAS HELICOPTER SYST,MESA,AZ. NR 7 TC 10 Z9 10 U1 0 U2 0 PU IOP PUBLISHING LTD PI BRISTOL PA TECHNO HOUSE, REDCLIFFE WAY, BRISTOL, ENGLAND BS1 6NX SN 0964-1726 J9 SMART MATER STRUCT JI Smart Mater. Struct. PD FEB PY 1996 VL 5 IS 1 BP 68 EP 75 DI 10.1088/0964-1726/5/1/008 PG 8 WC Instruments & Instrumentation; Materials Science, Multidisciplinary SC Instruments & Instrumentation; Materials Science GA UA064 UT WOS:A1996UA06400008 ER PT J AU Merkel, KG Cerny, CLA Bright, VM Schuermeyer, FL Monahan, TP Lareau, RT Kaspi, R Rai, AK AF Merkel, KG Cerny, CLA Bright, VM Schuermeyer, FL Monahan, TP Lareau, RT Kaspi, R Rai, AK TI Improved p-channeL InAlAs/GaAsSb HIGFET using Ti/Pt/Au ohmic contacts to beryllium implanted GaAsSb SO SOLID-STATE ELECTRONICS LA English DT Review ID FIELD-EFFECT TRANSISTORS; HETEROSTRUCTURE FET; TEMPERATURE-DEPENDENCE; HIGH TRANSCONDUCTANCE; MICROSTRUCTURE; RESISTANCE AB Ti/Pt/Au is demonstrated as an ohmic contact which provides a thermally stable, low resistance, electrical interface to beryllium implanted GaAs1-xSbx on InP. Ohmic contacts are characterized electrically using the transmission line method. An extremely low contact resistance (rho(c) < 3 x 10(-7) Omega . cm(2)) is measured for thermal processing temperatures to T = 450 degrees C. The contact withstands an ambient temperature of T = 250 degrees C for up to 500 h. Microstructural characterization of the metal-semiconductor interface is achieved using Auger electron spectroscopy, X-ray diffraction and cross-sectional transmission electron microscopy. Contact sintering at T = 250 degrees C penetrates native oxides and minimizes contact resistance through formation of tunneling regions. Thermal degradation of the contact at T = 475 degrees C results from Au indiffusion and Ga and Sb outdiffusion with additional formation of Ga3Pt5 and TiAu phases. A single metallization of Ti/Pt/Au is employed for the source, drain and gate of the In0.52Al0.48As/GaAs0.51Sb0.49 p-channel heterostructure insulated-gate field effect transistor (HIGFET). Improvements are realized in the source/drain contact reliability, external transconductance, output conductance and cutoff characteristics of the In0.52Al0.48As/GaAs0.51Sb0.49 HIGFET compared with previous designs using alloyed Au/Zn/Au source/drain contacts. External transconductance of g(me) = 5.3 mS/mm and an output conductance of g(o) = 0.21 mS/mm are achieved on devices with gate length and width dimensions of L(G) = 1 mu m and W-G = 10 mu m, respectively. C1 WRIGHT LAB,SOLID STATE ELECTR DIRECTORATE,WRIGHT PATTERSON AFB,OH 45433. USAF,INST TECHNOL,DEPT ELECT & COMP ENGN,WRIGHT PATTERSON AFB,OH 45433. USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,FT MONMOUTH,NJ 07703. WRIGHT STATE UNIV,RES CTR,DAYTON,OH 45435. UNIVERSAL ENERGY SYST INC,DAYTON,OH 45432. RP Merkel, KG (reprint author), PHILLIPS LAB,VTEE,KIRTLAND AFB,NM 87117, USA. NR 35 TC 5 Z9 5 U1 1 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0038-1101 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD FEB PY 1996 VL 39 IS 2 BP 179 EP 191 DI 10.1016/0038-1101(95)00154-9 PG 13 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA TR430 UT WOS:A1996TR43000001 ER PT J AU Abernathy, CR Pearton, SJ MacKenzie, JD Mileham, JR Bharatan, SR Krishnamoorthy, V Jones, KS HagerottCrawford, M Shul, RJ Kilcoyne, SP Zavada, JM Zhang, D Kolbas, RM AF Abernathy, CR Pearton, SJ MacKenzie, JD Mileham, JR Bharatan, SR Krishnamoorthy, V Jones, KS HagerottCrawford, M Shul, RJ Kilcoyne, SP Zavada, JM Zhang, D Kolbas, RM TI Growth and fabrication of GaN-InGaN microdisk laser structures SO SOLID-STATE ELECTRONICS LA English DT Article C1 SANDIA NATL LABS,ALBUQUERQUE,NM 87185. USA,RES OFF,RES TRIANGLE PK,NC 27709. N CAROLINA STATE UNIV,RALEIGH,NC 27695. RP Abernathy, CR (reprint author), UNIV FLORIDA,DEPT MAT SCI & ENGN,GAINESVILLE,FL 32611, USA. NR 7 TC 6 Z9 7 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0038-1101 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD FEB PY 1996 VL 39 IS 2 BP 311 EP 313 DI 10.1016/0038-1101(95)00177-8 PG 3 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA TR430 UT WOS:A1996TR43000021 ER PT J AU Elliott, DC Rodriquez, A AF Elliott, DC Rodriquez, A TI Cost effectiveness in trauma care SO SURGICAL CLINICS OF NORTH AMERICA LA English DT Review ID PENETRATING COLON INJURIES; MILD HEAD TRAUMA; BLUNT TRAUMA; CLINICAL PREDICTORS; COMPUTED-TOMOGRAPHY; FINANCIAL IMPACT; FIREARM INJURIES; SEVERITY SCORE; HOSPITAL COSTS; AORTIC INJURY AB Traumatic injury exacts high costs not only in terms of death but also in pain and suffering, years of lost productivity, and consumption of medical resources. Despite the staggering statistics, the American health care system has not yet developed cost-effective means of delivering trauma care. In fact, economic disincentives discourage the development and continuation of trauma care systems. Strategies for cost containment must focus on improved reimbursement rates for trauma care, increased government funding, cost-effective diagnostic and therapeutic procedures, and prevention of intentional and unintentional injuries. C1 UNIV MARYLAND,DEPT SURG,R ADAMS COWLEY SHOCK TRAUMA CTR,MED CTR,BALTIMORE,MD 21201. WALTER REED ARMY MED CTR,DEPT CRIT CARE MED,WASHINGTON,DC 20307. NR 101 TC 20 Z9 20 U1 1 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0039-6109 J9 SURG CLIN N AM JI Surg. Clin.-North Am. PD FEB PY 1996 VL 76 IS 1 BP 47 EP & DI 10.1016/S0039-6109(05)70421-7 PG 18 WC Surgery SC Surgery GA TV105 UT WOS:A1996TV10500006 PM 8629202 ER PT J AU Lee, YTM AF Lee, YTM TI Local and regional recurrence of carcinoma of the colon and rectum .2. Factors relating to operative technique SO SURGICAL ONCOLOGY-OXFORD LA English DT Review DE cancer; colon; rectum; recurrence; surgery ID LOW ANTERIOR RESECTION; ABDOMINO-PERINEAL RESECTION; SPHINCTER-SAVING RESECTION; TOTAL MESORECTAL EXCISION; LARGE BOWEL-CANCER; COLORECTAL-CANCER; CURATIVE SURGERY; POSTOPERATIVE RADIOTHERAPY; PROGNOSTIC-SIGNIFICANCE; MULTIVARIATE-ANALYSIS AB Despite many recent advances in the field of radiation therapy, chemotherapy and even immunotherapy, surgical resection remains the mainstay of curative treatment for carcinoma of the colon and rectum. Locoregional recurrence is a recognized type of failure, and it is the most direct measurement of the relevance of surgery to cancer control. Factors that influence relapse rates and sites deserve in-depth and periodical review. Local or locoregional (LR) recurrence implies the reappearance of carcinoma after an intended complete removal of the tumour. It is usually defined as tumour regrowth at the anastomosis or immediately within or contiguous to the operative area. For rectal cancer, the adjacent organs include the perineum, bladder and vagina; and LR failure includes perineal or pelvic lesions. Many reports studied only patients with colon or rectal cancers, while others presented their data of the colon and rectum together. In this review, I shall use colon, rectum and colorectum to designate the composition of each patient population. Published results from all available English sources were reviewed, concentrating on reports of the last 10 years. Data analysed by statistical methods are emphasized, and a probability of occurrence of one in 20 or less (P<0.05) is considered significant. Various clinicopathological factors of the tumour and host, and adjuvant radiotherapy that affected the LR recurrence rates have been presented in another paper (part I, 283-293). Technical details and issues relating to performance of the operation will be discussed in this paper (part II). Quantitative information presented here predate the wide use of laparoscopic or minimal invasive surgery in treating the primary tumour, and the polar practice of periodic colonoscopy, carcinoembryonic antigen (CEA) or computed tomography as regular follow-up tests. Thus, these baseline data will be useful to study the changes in rates and sites of recurrence in the future. RP Lee, YTM (reprint author), TRIPLER ARMY MED CTR,DEPT SURG,HONOLULU,HI 96859, USA. NR 71 TC 3 Z9 4 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0960-7404 J9 SURG ONCOL JI Surg. Oncol.-Oxf. PD FEB PY 1996 VL 5 IS 1 BP 1 EP 13 PG 13 WC Oncology; Surgery SC Oncology; Surgery GA UY375 UT WOS:A1996UY37500001 PM 8837299 ER PT J AU Adler, M Macdonald, DA Sellin, LC Parker, GW AF Adler, M Macdonald, DA Sellin, LC Parker, GW TI Effect of 3,4-diaminopyridine on rat extensor digitorum longus muscle paralyzed by local injection of botulinum neurotoxin SO TOXICON LA English DT Article ID NEUROMUSCULAR-JUNCTION; TETANUS TOXIN; NEUROTRANSMITTER RELEASE; SYNAPTOBREVIN; PROTEASE; SNAP-25 AB The actions of the K+ channel blocker, 3,4-diaminopyridine (3,4-DAP), were studied in the rat extensor digitorum longus (EDL) muscle following local inhibition of neuromuscular transmission by botulinum neurotoxin (BoNT). Local paralysis of the EDL muscle was induced by s.c. injections of BoNT serotypes A, B, E or F over the anterior tibialis muscle, One to 14 days later, the rats were anesthetized with urethane, and isometric twitch tensions following stimulation of the peroneal nerve were measured in situ. Muscles were paralyzed within 24 hr of administration of 5 mouse LD(50) units (U) of BoNT/A and remained inhibited for the entire 14-day period of observation. Similar levels of inhibition, but of shorter duration, were observed after local injection of 20 U of BoNT/E, 10(4) U of BoNT/B or 20 U of BoNT/F. 3,4-DAP (4 mg/kg, i.v.) potentiated twitch tensions markedly in BoNT/A intoxicated muscle. The increase in tension developed rapidly (halftime = 5.81 +/- 0.6 min), persisted for approximately 1 hr, then decayed slowly with a halftime of 25.2 +/- 4.6 min. Subsequent administration of 3,4-DAP restored tensions to the original maxima, and this procedure could be repeated up to eight times with no decrement. The action of 3,4-DAP was comparable when given 1, 2, 3 or 7 days after BoNT/A and enhanced when administered 14 days after toxin injection. 3,4-DAP was less effective in reversing BoNT/E-induced muscle paralysis and nearly ineffective in antagonizing the paralytic actions of BoNT/B or BoNT/F. The results indicate that 3,4-DAP is of benefit in BoNT/A and BoNT/E intoxication, but is of marginal value after exposure to serotypes B and F. C1 USA,MED RES INST INFECT DIS,DIV TOXINOL,FREDERICK,MD 21701. RP Adler, M (reprint author), USA,MED RES INST CHEM DEF,DIV PATHOPHYSIOL,NEUROTOXICOL BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 39 TC 34 Z9 34 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD FEB PY 1996 VL 34 IS 2 BP 237 EP 249 DI 10.1016/0041-0101(95)00127-1 PG 13 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA TY708 UT WOS:A1996TY70800007 PM 8711757 ER PT J AU Choy, FK Polyshchuk, V Zakrajsek, JJ Handschuh, RF Townsend, DP AF Choy, FK Polyshchuk, V Zakrajsek, JJ Handschuh, RF Townsend, DP TI Analysis of the effects of surface pitting and wear on the vibration of a gear transmission system SO TRIBOLOGY INTERNATIONAL LA English DT Article; Proceedings Paper CT International Tribology Conference (AUSTRIB 94) CY DEC, 1994 CL PERTH, AUSTRALIA AB A comprehensive procedure to simulate and analyse the vibrations in a gear transmission system with surface pitting, wear, and partial tooth fracture of the gear teeth is presented. An analytical model was developed where the effects of surface pitting and wear of the gear tooth were simulated by phase and magnitude changes in the gear mesh stiffness. Changes in the gear mesh stiffness were incorporated into each gear-shaft model during the global dynamic simulation of the system. The overall dynamics of the system were evaluated by solving for the transient dynamics of each shaft system simultaneously with the vibration of the gearbox structure. In order to reduce the number of degrees-of-freedom in the system, a modal synthesis procedure was used in the global transient dynamic analysis of the overall transmission system. An FFT procedure was used to transform the averaged time signal into the frequency domain for signature analysis. In addition, the Wigner-Ville distribution was also introduced to examine the gear vibration in the joint time-frequency domain for vibration pattern recognition. Experimental results obtained from a gear fatigue test rig at NASA Lewis Research Center were used to evaluate the analytical model. C1 NASA,WASHINGTON,DC. USA,RES LAB,LEWIS RES CTR,VEHICLE PROPULS DIRECTORATE,WASHINGTON,DC. RP Choy, FK (reprint author), UNIV AKRON,AKRON,OH 44325, USA. NR 13 TC 53 Z9 57 U1 0 U2 21 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0301-679X J9 TRIBOL INT JI Tribol. Int. PD FEB PY 1996 VL 29 IS 1 BP 77 EP 83 DI 10.1016/0301-679X(95)00037-5 PG 7 WC Engineering, Mechanical SC Engineering GA TZ961 UT WOS:A1996TZ96100011 ER PT J AU Shandera, KC Rozanski, TA Jafers, G AF Shandera, KC Rozanski, TA Jafers, G TI The necessity of voiding cystourethrogram in the pretransplant urologic evaluation SO UROLOGY LA English DT Article AB Objectives, To determine the efficacy of limited use of voiding cystourethrogram (VCUG) in the evaluation of patients for renal transplantation. Methods. A retrospective review of 439 patients who underwent renal transplantation between October 1983 and May 1995; however, since September 1993 we used VCUC selectively in the pretransplant evaluation. Results. Since September 1993, only 51% of our renal transplant patients had a VCUC as part of their pretransplant evaluation, Only one urologic complication has occurred in a 68-year-old man with a history of glomerulonephritis, He had an episode of acute urinary retention, which was treated successfully with a temporary suprapubic tube followed by medical therapy. Conclusions. Our preliminary results reveal no adverse outcomes associated with the selective use of VCUC in the pretransplant evaluation, and indicate that this study is of little value in the routine evaluation of these patients. C1 BROOKE ARMY MED CTR,DEPT SURG,UROL SURG SERV,SAN ANTONIO,TX 78234. WILFORD HALL USAF MED CTR,DEPT TRANSPLANTAT SURG,SAN ANTONIO,TX 78236. NR 5 TC 9 Z9 9 U1 0 U2 0 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0090-4295 J9 UROLOGY JI UROLOGY PD FEB PY 1996 VL 47 IS 2 BP 198 EP 200 DI 10.1016/S0090-4295(99)80415-4 PG 3 WC Urology & Nephrology SC Urology & Nephrology GA TW787 UT WOS:A1996TW78700009 PM 8607233 ER PT J AU Berg, NB Schenkman, NS Skoog, SJ Davis, CJ AF Berg, NB Schenkman, NS Skoog, SJ Davis, CJ TI Testicular masses associated with congenital adrenal hyperplasia: MRI findings SO UROLOGY LA English DT Article ID DIAGNOSIS C1 WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT UROL,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT RADIOL & NUCL MED,BETHESDA,MD 20814. UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. OREGON HLTH SCI UNIV,DIV UROL & RENAL TRANSPLANTAT,PORTLAND,OR 97201. ARMED FORCES INST PATHOL,DEPT GENITOURINARY PATHOL,WASHINGTON,DC 20306. NR 4 TC 4 Z9 4 U1 0 U2 0 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0090-4295 J9 UROLOGY JI UROLOGY PD FEB PY 1996 VL 47 IS 2 BP 252 EP 253 DI 10.1016/S0090-4295(99)80428-2 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA TW787 UT WOS:A1996TW78700025 PM 8607246 ER PT J AU Douglas, TH McCarthy, WF McLeod, DG Moul, JW AF Douglas, TH McCarthy, WF McLeod, DG Moul, JW TI Patient selection for experimental adjuvant therapy after radical prostatectomy SO UROLOGY LA English DT Letter C1 UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,CTR PROSTATE DIS RES,BETHESDA,MD 20814. RP Douglas, TH (reprint author), WALTER REED ARMY MED CTR,DEPT SURG,UROL SERV,WASHINGTON,DC 20307, USA. NR 3 TC 3 Z9 3 U1 0 U2 0 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0090-4295 J9 UROLOGY JI UROLOGY PD FEB PY 1996 VL 47 IS 2 BP 284 EP 285 DI 10.1016/S0090-4295(99)80436-1 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA TW787 UT WOS:A1996TW78700035 PM 8607254 ER PT J AU Grant, SA Salehzadeh, A AF Grant, SA Salehzadeh, A TI Calculation of temperature effects on wetting coefficients of porous solids and their capillary pressure functions SO WATER RESOURCES RESEARCH LA English DT Article ID CONDUCTIVITY; MOISTURE; MEDIA; SOILS AB We explored the notion that changes in wetting coefficients of porous solids contributed to the temperature sensitivities of capillary pressure functions (CPFs). A chemical-thermodynamic explanation for these contributions was developed. If the temperature sensitivities of CPFs were due to capillarity (i.e., due to temperature-induced changes in liquid-gas interfacial tensions or wetting coefficients), then for a given degree of saturation the ratios of capillary pressures to their temperature derivatives should have been linear functions of thermodynamic temperature with slopes equal to 1. This indeed was the case for samples of both synthetic and natural porous media. Further, the estimated intercepts of these linear functions indicated that changes with temperature of these porous materials' wetting coefficients had pronounced effects on temperature sensitivities of their CPFs. A simple model for temperature effects on CPFs, which was derived from the linear relationship between temperature and the ratio of capillary pressure to its temperature derivative, could be fitted precisely by nonlinear regression to CPFs of two soils determined at four temperatures. C1 UNIV MICHIGAN,DEPT ENVIRONM & WATER RESOURCES ENGN,ANN ARBOR,MI 48109. RP Grant, SA (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 30 TC 57 Z9 62 U1 1 U2 5 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0043-1397 J9 WATER RESOUR RES JI Water Resour. Res. PD FEB PY 1996 VL 32 IS 2 BP 261 EP 270 DI 10.1029/95WR02915 PG 10 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA TT025 UT WOS:A1996TT02500003 ER PT J AU Strawn, RC Biswas, R AF Strawn, RC Biswas, R TI Numerical simulations of helicopter aerodynamics and acoustics SO JOURNAL OF COMPUTATIONAL AND APPLIED MATHEMATICS LA English DT Article; Proceedings Paper CT 6th International Congress on Computational and Applied Mathematics CY JUL 26-30, 1994 CL LOUVAIN, BELGIUM SP Belgian Natl Sci Fdn, IBM, Belgium, BBL Antwerpen, SAS Inst, Avia Belgomazout, United Airlines DE helicopter aerodynamics and acoustics; computational fluid dynamics; Kirchhoff integration; dynamic mesh adaption; structured and unstructured grids; rotor in hover and forward flight AB This paper demonstrates several new methods for computing acoustic signals from helicopter rotors in hover and forward flight. Aerodynamic and acoustic solutions in the near field are computed with two different finite-volume flow solvers for the Euler equations. A solution-adaptive unstructured-grid Euler solver models a rotor in hover while a more conventional structured-grid solver is used for forward flight calculations. A nonrotating cylindrical surface is then placed around the entire rotor system. This surface moves subsonically with the rotor hub in forward flight. The finite-volume solution is interpolated onto this cylindrical surface at every time step and a Kirchhoff integration propagates the acoustic signal to the far field. Computed values for high-speed impulsive noise in hover and forward flight show excellent agreement with experimental data. Results from the combined finite-volume/Kirchhoff method offer high accuracy with reasonable computer resource requirements. C1 NASA,AMES RES CTR,US ARMY AFDD,MOFFETT FIELD,CA 94035. NASA,AMES RES CTR,RIACS,MOFFETT FIELD,CA 94035. NR 13 TC 4 Z9 5 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0377-0427 J9 J COMPUT APPL MATH JI J. Comput. Appl. Math. PD JAN 31 PY 1996 VL 66 IS 1-2 BP 471 EP 483 DI 10.1016/0377-0427(95)00171-9 PG 13 WC Mathematics, Applied SC Mathematics GA UL887 UT WOS:A1996UL88700038 ER PT J AU Schodel, F Peterson, D Hughes, J Wirtz, R Milich, D AF Schodel, F Peterson, D Hughes, J Wirtz, R Milich, D TI Hybrid hepatitis B virus core antigen as a vaccine carrier moiety .1. Presentation of foreign epitopes SO JOURNAL OF BIOTECHNOLOGY LA English DT Article; Proceedings Paper CT Symposium on New Approaches to Vaccine Development (NAVD 95) CY APR 11-14, 1995 CL VIENNA, AUSTRIA SP Austrian Soc Biotechnol DE HBcAg; hepatitis B virus; core particle; epitope presentation; malaria; circumsporozoite antigen; malaria vaccine ID T-CELL; IMMUNOGENICITY; RECOGNITION AB Hepatitis B virus (HBV) core antigen (HBcAg) is a highly immunogenic subviral particle. Here, we review recent progress in the use of HBcAg as a carrier moiety for heterologous epitopes. To define surface exposed and immunogenic insertion sites for foreign epitopes in HBcAg, peptidic epitopes representing binding sites for virus neutralizing antibodies on the HBV surface antigens were inserted at different positions within HBcAg using genetic engineering in an Escherichia coli expression system (Schodel et al, (1992) J. Virol. 66, 106-114). While fusion to the N-terminus required a linker to become surface accessible, both fusion to the N-terminus and to the C-terminus was compatible with particle assembly and preserved the native antigenicity and immunogenicity of HBcAg. Fusion to an immunodominant internal site of HBcAg reduced the HBcAg immunogenicity and antigenicity and most drastically enhanced the immunogenicity of the inserted foreign epitope. This internal site of HBcAg was used to express circumsporozoite antigen (CS) repeat epitopes of two rodent malaria parasites and of Plasmodium falciparum (Schodel et al. (1994b) J. Exp. Med. 180, 1037-1046 and Schodel et al. (1995a) 95th ASM General Meeting, Washington DC, Abstr. E61). When purified from recombinant Salmonella typhimurium, the hybrid HBcAg-CS proteins were particulate and displayed CS antigenicity as well as reduced HBc antigenicity, as compared to native HBcAg. Immunization of several mouse strains with HBcAg-CS hybrid particles resulted in high titered serum anti-CS antibodies representing all murine IgG isotypes. Immunization of mice with HBcAg or HBcAg-CS particles formulated on alum, complete Freunds or incomplete Freunds adjuvant resulted in equivalent anti-CS and anti-HBc serum antibody titres. The possible influence of carrier-specific immunosuppression was examined and pre-existing immunity to HBcAg did not significantly alter the immunogenicity of hybrid HBcAg particles suggesting that they would be useful carrier moieties for repeated immunizations against multiple haptens or in immune subjects after HBV infection. Examination of T cell recognition of HBcAg-CS particles revealed that HBcAg-specific T cells were universally primed and CS-specific T cells were primed if the insert contained a CS-specific T cell recognition site. This indicates that the internal amino acid position in HBcAg is permissive for the inclusion of heterologous functional T helper as well as B cell epitopes. BALB/c mice immunized with HBcAg-CS1 were protected against P. berghei challenge to 90% and 100%, respectively, in two independent experiments. C1 VIRGINIA COMMONWEALTH UNIV, DEPT BIOCHEM, RICHMOND, VA 23298 USA. WALTER REED ARMY INST RES, DEPT ENTOMOL, WASHINGTON, DC 20307 USA. SCRIPPS RES INST, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USA. RP Schodel, F (reprint author), HOP EDOUARD HERRIOT, INSERM U80, PAVILLON P, F-69437 LYON 03, FRANCE. FU NIAID NIH HHS [AI20720, AI33562] NR 14 TC 28 Z9 40 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-1656 J9 J BIOTECHNOL JI J. Biotechnol. PD JAN 26 PY 1996 VL 44 IS 1-3 BP 91 EP 96 DI 10.1016/0168-1656(95)00118-2 PG 6 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA TU634 UT WOS:A1996TU63400014 PM 8717391 ER PT J AU LeClaire, RD Kell, W Bavari, S Smith, TJ Hunt, RE AF LeClaire, RD Kell, W Bavari, S Smith, TJ Hunt, RE TI Protective effects of niacinamide in staphylococcal enterotoxin-B-induced toxicity SO TOXICOLOGY LA English DT Article DE Staphylococcal enterotoxin; immunotherapy; niacinamide; interleukin-10; mouse ID CLASS-II MHC; HUMAN ENDOTHELIAL-CELLS; MOUSE INTERFERON-GAMMA; DR ANTIGEN EXPRESSION; TUMOR-NECROSIS-FACTOR; T-CELLS; HLA-DR; MOLECULE EXPRESSION; CYTOKINE PRODUCTION; LETHAL SHOCK AB Staphylococcal enterotoxins (SE) interact with major histocompatibility complex (MHC) class II cell-surface receptors, eliciting signal transduction in antigen-presenting cells (APC). Subsequent toxin-dass II complex interaction with specific T-cell receptors induces T-cell activation. We investigated the effect of niacinamide and interleukin (IL)-10 on SEB-induced responses. In a macrophage cell line, niacinamide (ED(50) - 2 mM) and IL-10 (ED(50) - 7 U/ml) inhibited interferon (IFN)-gamma-induced MHC class II expression in a dose-dependent manner. Also, niacinamide was a potent inhibitor of T-cell proliferation induced by SEB (ED(50) - 1 mM) while IL-10 had minimal effects. In mice, the temporal responses of IL-1 alpha, tumor necrosis factor (TNF)-alpha, IL-2, and IFN-gamma evoked by SEB were synergistically potentiated by lipopolysaccharide (LPS). Lethality occurred only when SEB was potentiated by LPS. Niacinamide or IL-10 improved survival of mice after lethal SEB challenge. Niacinamide reduced cytokine serum levels, although the pattern differed from that of IL-10. Niacinamide primarily reduced IL-2 and IFN-gamma, while IL-10 predominantly reduced IL-1 alpha and TNF-alpha. The immunomodulatory effects of niacinamide observed on SEB-induced activation of APC and T-cells in vitro and in the LPS potentiated murine model for SEB-induced toxicity suggest it may have therapeutic value. RP LeClaire, RD (reprint author), USA,MED RES INST INFECT DIS,DIV TOXICOL,FREDERICK,MD 21702, USA. NR 45 TC 25 Z9 26 U1 0 U2 0 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0300-483X J9 TOXICOLOGY JI Toxicology PD JAN 22 PY 1996 VL 107 IS 1 BP 69 EP 81 DI 10.1016/0300-483X(95)03202-Q PG 13 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA TV578 UT WOS:A1996TV57800008 PM 8597033 ER PT J AU Blake, DR Chen, TY Smith, TY Wang, CJL Wingenter, OW Blake, NJ Rowland, FS Mayer, EW AF Blake, DR Chen, TY Smith, TY Wang, CJL Wingenter, OW Blake, NJ Rowland, FS Mayer, EW TI Three-dimensional distribution of nonmenthane hydrocarbons and halocarbons over the northwestern Pacific during the 1991 Pacific Exploratory Mission (PEM-West A) SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID C2-C5 HYDROCARBONS; CHEMISTRY; TROPOSPHERE AB A total of 1667 whole air samples were collected onboard the NASA DC-8 aircraft during the Ci-week Pacific Exploratory Mission over the western Pacific (PEM-West A) in September and October 1991. The samples were assayed for 15 C-2-C-7 hydrocarbons and six halocarbons. Latitudinal(0.5 degrees S to 59.5 degrees N) and longitudinal (114 degrees E to 122 degrees W) profiles were obtained from samples collected between ground level and 12.7 km. Thirteen of the 18 missions exhibited at least one vertical profile where the hydrocarbon mixing ratios increased with altitude. Longitude-latitude color patch plots at three altitude levels and three-dimensional color latitude altitude and longitude-altitude contour plots exhibit a significant number of middle-upper tropospheric pollution events. These and several lower tropospheric pollution plumes were characterized by comparison with urban data from Tokyo and Hong Kong, as well as with natural gas and the products from incomplete combustion. Elevated levels of nonmethane hydrocarbons (NMHC) and other trace gases in the upper-middle free troposphere were attributed to deep convection over the Asian continent and to typhoon-driven convection near the western Pacific coast of Asia. In addition, NMHCs and CH3CCl3 were found to be useful tracers with which to distinguish hydrocarbon and halocarbon augmented plumes emitted from coastal Asian cities into the northwestern Pacific. C1 US MIL ACAD, DEPT CHEM, W POINT, NY 10996 USA. RP Blake, DR (reprint author), UNIV CALIF IRVINE, DEPT CHEM, IRVINE, CA 92717 USA. NR 25 TC 115 Z9 116 U1 0 U2 4 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD JAN 20 PY 1996 VL 101 IS D1 BP 1763 EP 1778 DI 10.1029/95JD02707 PG 16 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA TR616 UT WOS:A1996TR61600031 ER PT J AU Jensen, GM Goodin, DB Bunte, SW AF Jensen, GM Goodin, DB Bunte, SW TI Density functional and MP2 calculations of spin densities of oxidized 3-methylindole: Models for tryptophan radicals SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Article ID CYTOCHROME-C PEROXIDASE; ELECTRON-PARAMAGNETIC RESONANCE; NUCLEAR DOUBLE-RESONANCE; SITE-DIRECTED MUTANTS; COMPOUND-I; HYDROGEN-PEROXIDE; PHOTO-CIDNP; SPECTRA; ENDOR; HEME AB Ab initio calculations have been carried out on 3-methylindole, and the cation and neutral radicals of 3-methylindole, using density functional theory (DFT), the Becke3-Lee-Yang-Parr functional, and the 6-31G*, 6-31+G*, 3-21G*, and TZ2P basis sets. Optimized geometries, vibrational frequencies, and for the radicals, atomic spin densites are calculated. The latter are compared to experimental spin densities recently determined for the tryptophan-191 radical of compound ES of the enzyme cytochrome-c-peroxidase. The DFT spin densities for the cation radical of 3-methylindole are in excellent agreement with the data for the tryptophan-191 radical, which supports the conclusion that the tryptophan radical is a cation radical. The results are compared to calculations using second-order Moller-Plesset theory (MP2) and the 6-31G** basis set. The MP2 spin densities are in significantly worse agreement with the experimental spin densities. C1 USA, RES LAB, AMSRL, WT, PC, ABERDEEN PROVING GROUND, MD 21005 USA. SCRIPPS RES INST, DEPT BIOL MOLEC, LA JOLLA, CA 92037 USA. NR 54 TC 51 Z9 52 U1 2 U2 9 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD JAN 18 PY 1996 VL 100 IS 3 BP 954 EP 959 DI 10.1021/jp951795c PG 6 WC Chemistry, Physical SC Chemistry GA TQ279 UT WOS:A1996TQ27900004 ER PT J AU Hays, MD Hoyer, MH Glasow, PF AF Hays, MD Hoyer, MH Glasow, PF TI New forceps delivery technique for coil occlusion of patent ductus arteriosus SO AMERICAN JOURNAL OF CARDIOLOGY LA English DT Article C1 BROOKE ARMY MED CTR,PEDIAT CARDIOL SECT,FT SAM HOUSTON,TX 78234. WILFORD HALL USAF MED CTR,DEPT PEDIAT,PEDIAT CARDIOL SERV,SAN ANTONIO,TX 78236. NR 6 TC 35 Z9 37 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0002-9149 J9 AM J CARDIOL JI Am. J. Cardiol. PD JAN 15 PY 1996 VL 77 IS 2 BP 209 EP 211 DI 10.1016/S0002-9149(96)90603-7 PG 3 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA TQ963 UT WOS:A1996TQ96300025 PM 8546098 ER PT J AU Dovgalenko, GE Klotz, M Salamo, GJ Wood, GL AF Dovgalenko, GE Klotz, M Salamo, GJ Wood, GL TI Optically induced birefringence in bacteriorhodopsin as an optical limiter SO APPLIED PHYSICS LETTERS LA English DT Article ID FILMS AB Experimental data are presented, which demonstrates an optical limiter based on a large birefringence which is optically induced in bacteriorhodopsin. The induced birefringence is observed to be a function of incident intensity, but saturates at a value of about 0.454 W/cm(2). A measured value of Delta n of 6.6X10(-4) at a wavelength of 514 nm is reported. The observed birefringence is found to be in good agreement with a proposed model. (C) 1996 American Institute of Physics. C1 USA,RES LAB,FT BELVOIR,VA 22060. RP Dovgalenko, GE (reprint author), UNIV ARKANSAS,DEPT PHYS,FAYETTEVILLE,AR 72701, USA. NR 12 TC 29 Z9 32 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JAN 15 PY 1996 VL 68 IS 3 BP 287 EP 289 DI 10.1063/1.116061 PG 3 WC Physics, Applied SC Physics GA TP438 UT WOS:A1996TP43800003 ER PT J AU Choi, KK Tidrow, MZ Chang, WH AF Choi, KK Tidrow, MZ Chang, WH TI Electron energy relaxation in infrared hot-electron transistors SO APPLIED PHYSICS LETTERS LA English DT Article ID TRANSPORT; GAAS; SEMICONDUCTORS AB In hot-electron transistors and infrared hot-electron transistors, the energy distribution rho(E) of the injected electrons after Passing through the base can be directly measured at the collector. In this letter a theoretical calculation on rho(E) is presented, taking optical phonon emission and plasmon emission into account. We found that the relative contributions of these two mechanisms depend on the base doping density N-d. When N-d is less than 3.3 X 10(17) cm(-3), phonon emission dominates. For a larger N-d, plasmon emission becomes more important. We applied the calculation to devices with different N-d, and obtained quantitative agreement with the experiment. (C) 1996 American Institute of Physics. RP Choi, KK (reprint author), USA,RES LAB,PHYS SCI DIRECTORATE,FT MONMOUTH,NJ 07703, USA. RI Choi, Kwong-Kit/K-9205-2013 NR 11 TC 1 Z9 1 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JAN 15 PY 1996 VL 68 IS 3 BP 358 EP 360 DI 10.1063/1.116715 PG 3 WC Physics, Applied SC Physics GA TP438 UT WOS:A1996TP43800027 ER PT J AU Olsen, SB Tang, DB Jackson, MR Gomez, ER Ayala, B Alving, BM AF Olsen, SB Tang, DB Jackson, MR Gomez, ER Ayala, B Alving, BM TI Enhancement of platelet deposition by cross-linked hemoglobin in a rat carotid endarterectomy model SO CIRCULATION LA English DT Article DE hemoglobin; nitric oxide; platelets; surgery ID NITRIC-OXIDE; VASCULAR ENDOTHELIUM; BLEEDING-TIME; AGGREGATION; ADHESION; INHIBITION; INVIVO AB Background Purified human cross-linked hemoglobin, which is now being used in clinical trials, increases mean arterial pressure through binding of nitric oxide (NO). We postulated that binding of NO by cross-linked hemoglobin (alpha alpha Hb) could also increase platelet deposition at sites of subintimal injury. Methods and Results Male Sprague-Dawley rats were infused with alpha alpha Hb (0.88 g/kg, n=8) or with the NO synthase inhibitor NG-monomethyl-L-arginine (L-NMMA, 30 mg/kg, n=7) before undergoing microsurgical carotid endarterectomy. In-111-labeled platelets were infused after endarterectomy, and platelet deposition was measured 20 minutes later. In control endarterectomized rats (n=8), mean platelet deposition was 7.7+/-0.7x10(6)/mm(2). Platelet deposition was significantly increased above controls in rats that received alpha alpha Hb (13.2+/-0.9x10(6)/mm(2), P=.0004) and in rats infused with L-NMMA (13.9+/-1.0x10(6)/mm(2), P=.0002). The increase was prevented by infusion of L-arginine (150 mg/kg) immediately after alpha alpha Hb or L-NMMA. To determine whether aspirin (ASA) blocked the increased deposition induced by alpha alpha Hb, rats received oral ASA (10 mg/kg) 18 hours before endarterectomy. Platelet deposition in animals receiving ASA alone was 6.4+/-0.9x10(6)/mm(2) (n=8). This was significantly increased to 10.8+/-0.8x10(6)/mm(2) (P=.002) for the ASA-treated group that received alpha alpha Hb at the time of endarterectomy (n=8). The prolonged bleeding times induced by ASA were unaffected by the infusion of alpha alpha Hb. Conclusions These data suggest that in a rat endarterectomy model, alpha alpha Hb increases platelet deposition at sites of subintimal injury by binding NO. Increased deposition induced by alpha alpha Hb can be prevented by administration of L-aginine but not by pretreatment with aspirin. C1 WALTER REED ARMY INST RES,DEPT HEMATOL & VASC BIOL,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,DEPT BIOMETR & STAT,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,PERIPHERAL VASC SURG SERV,WASHINGTON,DC 20307. NR 31 TC 59 Z9 60 U1 0 U2 0 PU AMER HEART ASSOC PI DALLAS PA 7272 GREENVILLE AVENUE, DALLAS, TX 75231-4596 SN 0009-7322 J9 CIRCULATION JI Circulation PD JAN 15 PY 1996 VL 93 IS 2 BP 327 EP 332 PG 6 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA TP779 UT WOS:A1996TP77900020 PM 8548906 ER PT J AU Billock, VA Harding, TH AF Billock, VA Harding, TH TI Evidence of spatial and temporal channels in the correlational structure of human spatiotemporal contrast sensitivity SO JOURNAL OF PHYSIOLOGY-LONDON LA English DT Article ID FREQUENCY-SELECTIVITY; HUMAN-VISION; DISCRIMINATION; ORIENTATION; PERCEPTION; THRESHOLD; MASKING AB 1. The statistical correlation of detection thresholds for pairs of stimuli should be higher for stimuli detected by the same mechanism than for stimuli detected by different mechanisms - a property that can be used to probe the visual mechanisms that underlie detection. 2. Correlation of contrast sensitivities for pairs of spatiotemporal stimuli is approximately a linear function of spatial or temporal frequency separation in octaves. Using the slope of this function as an index of neural processing gave results consistent with: more spatial mechanisms than temporal; more spatial mechanisms at low temporal frequencies than at high; and at least two temporal mechanisms active at spatial requencies up to 22.6 cycles deg(-1). 3. This method of analysing sensitis ity data is insensitive to experimental conditions and applicable to any sensory detection task mediated by tuned channels. In addition to being applicable to psychophysical sensitivity measurements, it may also be useful in analysing some kinds of electrophysiological measurements that pool the responses from many active mechanisms (such as evoked potentials). C1 USA, AEROMED RES LAB, SENSORY RES DIV, FT RUCKER, AL 36362 USA. FU NIMH NIH HHS [MH42900, 5T32MH19116] NR 36 TC 18 Z9 21 U1 0 U2 2 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0022-3751 J9 J PHYSIOL-LONDON JI J. Physiol.-London PD JAN 15 PY 1996 VL 490 IS 2 BP 509 EP 517 PG 9 WC Neurosciences; Physiology SC Neurosciences & Neurology; Physiology GA TT577 UT WOS:A1996TT57700019 PM 8821147 ER PT J AU Dubey, JP Morales, JA Villalobos, P Lindsay, DS Blagburn, BL Topper, MJ AF Dubey, JP Morales, JA Villalobos, P Lindsay, DS Blagburn, BL Topper, MJ TI Neosporosis-associated abortion in a dairy goat SO JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION LA English DT Article ID TISSUE-SECTIONS; CANINUM; INFECTION; CATTLE; DOGS AB Neospora caninum tachyzoites and tissue cysts were found in tissues of a goat fetus aborted after 3.5 months of gestation. The fetus had hydrocephalus and a hypoplastic cerebellum. The predominant lesion in the fetus was severe encephalitis associated with numerous N caninum tissue cysts. Parasites in fetal tissues reacted positively with N caninum antibodies in immunohistochemical tests. The doe was clinically normal and had a 1:800 antibody titer to N caninum as determined by use of an indirect fluorescent antibody test 9 months after abortion. Five of 77 other does from this herd also had indirect fluorescent antibody titers to N caninum that were greater than or equal to 1:100. C1 UNIV NACL,DEPT PATOL,ESCUELA MED VET,HEREDIA,COSTA RICA. UNIV NACL,CATEDRA CLIN ESPECIES MAYORES,ESCUELA MED VET,HEREDIA,COSTA RICA. AUBURN UNIV,COLL VET MED,DEPT PATHOBIOL,AUBURN,AL 36849. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV PATHOL,WASHINGTON,DC 20307. RP Dubey, JP (reprint author), USDA ARS,BELTSVILLE AGR RES CTR,INST LIVESTOCK & POULTRY SCI,PARASITE BIOL & EPIDEMIOL LAB,BELTSVILLE,MD 20705, USA. RI Lindsay, David/G-8891-2016 OI Lindsay, David/0000-0002-0592-8321 NR 11 TC 48 Z9 49 U1 0 U2 0 PU AMER VETERINARY MEDICAL ASSOC PI SCHAUMBURG PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 SN 0003-1488 J9 J AM VET MED ASSOC JI J. Am. Vet. Med. Assoc. PD JAN 15 PY 1996 VL 208 IS 2 BP 263 EP & PG 4 WC Veterinary Sciences SC Veterinary Sciences GA TP474 UT WOS:A1996TP47400024 PM 8567387 ER PT J AU Sirenko, YM Jeon, JB Kim, KW Littlejohn, MA Stroscio, MA AF Sirenko, YM Jeon, JB Kim, KW Littlejohn, MA Stroscio, MA TI Envelope-function formalism for valence bands in wurtzite quantum wells SO PHYSICAL REVIEW B LA English DT Article ID LIGHT-EMITTING-DIODES; SINGLE-CRYSTAL GAN; HOLE SUBBANDS; UNIAXIAL-STRESS; NITRIDE; CDS AB A theoretical treatment of the valence-band spectrum of wurtzite-type materials is developed starting from the Rashba-Sheka-Pikus (RSP) 6x6 matrix Hamiltonian for coupled Gamma(9), Gamma(7), and Gamma(7) levels. A unitary transformation is applied in order to diagonalize the RSP Hamiltonian to two 3X3 blocks and the results are compared with those obtained for cubic structures [C. Y.-P. Chao and S. L. Chuang, Phys. Rev. B 46, 4110 (1992)]. Using the diagonalized form of the Hamiltonian, a solution for hole states in wurtzite quantum wells (QW's) is constructed and explicit expressions for the QW valence subband edges are obtained. We suggest that parameters of the RSP Hamiltonian for wurtzite structures can be deduced from experimental observations of the energy separation between edges of the hole subbands in QW's. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP Sirenko, YM (reprint author), N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695, USA. NR 63 TC 61 Z9 61 U1 3 U2 5 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD JAN 15 PY 1996 VL 53 IS 4 BP 1997 EP 2009 DI 10.1103/PhysRevB.53.1997 PG 13 WC Physics, Condensed Matter SC Physics GA TU730 UT WOS:A1996TU73000046 ER PT J AU Manaa, MR Chabalowski, CF AF Manaa, MR Chabalowski, CF TI An ab initio study of the structures of cyclic N4O2 SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Article ID FORBIDDEN RADIATIONLESS DECAY; MOLECULAR CALCULATIONS; POLYATOMIC SYSTEMS; BASIS SETS; CYCLOTETRAOXYGEN; DISSOCIATION; SINGLE; ENERGY; ATOMS; DIMER AB The structures of the cyclic N4O2 molecule are investigated using three levels of nb initio electronic structure methods. Hartree-Fock self-consistent-field (SCF), second-order Moller-Plesset perturbation theory (MP2), and quadratic configuration interaction including single and double substitutions (QCISD) calculations are performed employing two basis sets of double-zeta plus polarization (DZP) and a triple(plus)-zeta double polarization (TZ-2P) quality. Two structures are located. A boat conformation (C-2v structure) is determined to be a minimum equilibrium structure with exothermicity of similar to 80, 140, and 100 kcal/mol relative to dissociation to 2N(2)O, 2N(2) + O-2, and 2NO + N-2, respectively. A planar (D-2h, structure) previously reported to be a minimum [Jones, W. H. J. Phys. Chem. 1992, 96, 5184] is confirmed in this study to be a transition state (saddle point) lying similar to 7-10 kcal/mol above the boat minimum as calculated at all levels of theory. A search for a chair and a twisted conformation has proven unsuccessful. Harmonic vibrational frequencies and infrared intensities are reported for both optimized boat and planar structures at all levels of theory. The consideration of the stable form of this molecule as a high energy density-material is discussed. C1 USA,RES LAB,PC,WT,AMSRL,ABERDEEN PROVING GROUND,MD 21005. NR 35 TC 7 Z9 7 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD JAN 11 PY 1996 VL 100 IS 2 BP 611 EP 615 DI 10.1021/jp952008e PG 5 WC Chemistry, Physical SC Chemistry GA TP942 UT WOS:A1996TP94200031 ER PT J AU Writer, JV DeFraites, RF Brundage, JF AF Writer, JV DeFraites, RF Brundage, JF TI Comparative mortality among US military personnel in the Persian Gulf region and worldwide during Operations Desert Shield and Desert Storm SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID DEATH AB Objective.-To determine cause-specific mortality rates among US troops stationed in the Persian Gulf region and compare them with those of US troops serving elsewhere during Operations Desert Shield and Desert Storm. Design.-Retrospective cohort. Population.-US men and women on active duty from August 1, 1990, through July 31, 1991. Main Outcome Measures.-Deaths occurring among all active-duty US military persons during the 1-year study period. Age-adjusted mortality rates among US troops stationed in the Persian Gulf region were compared with rates projected from mortality rates among troops on active duty elsewhere. Results.-A total of 1769 active-duty persons died during the study period, 372 in the Persian Gulf region and 1397 elsewhere. Of the 372 deaths in the Persian Gulf region, 147 (39.5%) occurred as a direct result of combat during the war, 194 (52.2%) resulted from injuries not incurred in battle, and 30 (8%) resulted from illness. Twenty-three of the deaths due to illness were considered unexpected or cardiovascular deaths. Based on age-adjusted mortality rates observed among US troops on active duty outside the Persian Gulf region, 165 deaths from unintentional injury and 32 deaths from illness (20 of which were unexpected or cardiovascular) would have been anticipated among Persian Gulf troops. Conclusion.-Except for deaths from unintentional injury, US troops in the Persian Gulf region did not experience significantly higher mortality rates than US troops serving elsewhere. There were no clusters of unexplained deaths. The number and circumstances of nonbattle deaths among Persian Gulf troops were typical for the US military population. C1 USA,CTR HLTH PROMOT & PREVENT MED,EPIDEMIOL & DIS SURVEILLANCE DIRECTORATE,ABERDEEN PROVING GROUND,MD. RP Writer, JV (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV PREVENT MED,WASHINGTON,DC 20307, USA. NR 16 TC 60 Z9 60 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD JAN 10 PY 1996 VL 275 IS 2 BP 118 EP 121 DI 10.1001/jama.275.2.118 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA TN280 UT WOS:A1996TN28000027 PM 8531306 ER PT J AU Celentano, DD Nelson, KE Suprasert, S Eiumtrakul, S Tulvatana, S Kuntolbutra, S Akarasewi, P Matanasarawoot, A Wright, NH Sirisopana, N Theetranont, C AF Celentano, DD Nelson, KE Suprasert, S Eiumtrakul, S Tulvatana, S Kuntolbutra, S Akarasewi, P Matanasarawoot, A Wright, NH Sirisopana, N Theetranont, C TI Risk factors for HIV-1 seroconversion among young men in northern Thailand SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; HETEROSEXUAL TRANSMISSION; INFECTION; AIDS; AFRICA; FEMALE; PROSTITUTES; TYPE-1; SPREAD; UGANDA AB Objective.-To identify behavioral and sociodemographic risk factors for incident human immunodeficiency virus-1 (HIV-1) infection among healthy young men in northern Thailand. Design.-Men inducted into military service in northern Thailand in May and November 1991 were followed at 6-month intervals until discharge 2 years later. Trained nonmilitary interviewers identified risk factors for HIV-1 infection through interviews with the men. Setting.-Thirteen military bases in northern Thailand. Participants.-A total of 1932 seronegative men, aged 19 to 23 years (average age, 21 years) at enrollment, conscripted into the Royal Thai Army and Air Force from six upper-northern Thai provinces. Main Outcome Measures.-Human immunodeficiency virus-1 seroincidence as determined through enzyme-linked immunosorbent assay and verified by Western blot, and univariate and multivariate analyses of risk factors related to H1V-1 incidence. Results.-A total of 85 men seroconverted to HIV-1 over the period of observation, giving an incidence rate of 2.43 per 100 person-years. Factors strongly associated with HIV-1 seroconversion were frequency of visits to female commercial sex workers (CSWs), sex with men, and incident sexually transmitted diseases (STDs). High frequency of condom use showed a significant (P<.001) protective effect for HIV-1 incidence among men with a history of recent sex with female CSWs in univariate analysis, but a multivariate model demonstrated no difference in HIV-1 seroconversion rates by consistency of condom use. Multivariate analysis incorporating condom use showed that having sex with men (adjusted relative risk [RR], 2.59; 95% confidence interval [CI], 1.08 to 6.25), having sex with CSWs (adjusted RR ranged from 2.54 [95% CI, 1.81 to 3.58] to 2.74 [95% CI, 1.56 to 4.81]), and incident STDs (adjusted RR, 2.38 [95% CI, 1.31 to 4.32]) to be predictors of incident HIV-1 infection. Substance use was not associated with HIV-1 seroconversion rates in multivariate analysis. Conclusion.-The HIV-1 incidence in this cohort of young men appears to be primarily attributable to having sex with female CSWs. Condom use provided some protection, although nor in multivariate analysis; however, condom use has previously been shown likely to be useful in preventing HIV-1 transmission. Thus, programs to increase effective condom use in brothels are essential. Efforts to extend condom use to non-CSW partners are especially needed. More effective prevention and treatment of STDs may also be necessary to decrease HIV-1 infection in this population. C1 JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT EPIDEMIOL,BALTIMORE,MD 21205. CHIANG MAI UNIV,DEPT FAMILY MED,CHIANG MAI 50000,THAILAND. CHIANG MAI UNIV,OFF PRESIDENT,CHIANG MAI 50000,THAILAND. MINIST PUBL HLTH,ROYAL THAI AF,CHIANG MAI,THAILAND. MINIST PUBL HLTH,ROYAL THAI ARMY,CHIANG MAI,THAILAND. ROBERT WOOD JOHNSON MED SCH,PISCATAWAY,NJ. ARMED FORCES RES INST MED SCI,BANGKOK 10400,THAILAND. RP Celentano, DD (reprint author), JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT HLTH POLICY & MANAGEMENT,624 N BROADWAY,BALTIMORE,MD 21205, USA. NR 60 TC 54 Z9 55 U1 1 U2 3 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD JAN 10 PY 1996 VL 275 IS 2 BP 122 EP 127 DI 10.1001/jama.275.2.122 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA TN280 UT WOS:A1996TN28000028 PM 8531307 ER PT J AU Tauber, A Tidrow, SC Finnegan, RD Wilber, WD AF Tauber, A Tidrow, SC Finnegan, RD Wilber, WD TI HTSC substrate and buffer layer compounds, A(2)MeSbO(6) where A=Ba,Sr and Me=Sc,In and Ga SO PHYSICA C LA English DT Article ID MICROWAVE AB Compounds in the series A(2)MeSbO(6) where A = Ba, Sr and Me = Sc, In and Ga have been used as substrate/buffer layers with YBa2Cu3O7-delta thin films. These materials were prepared by solid-state reaction of the oxides and carbonates. The compounds are ordered perovskites except for Ba2InSbO6. All compounds are cubic except Sr2ScSbO6 and Sr2GaSbO6 which are pseudo-cubic, tetragonal. Dielectric constant and loss tangent are reported for each bulk compound. Herein is described the successful deposition of thin films A(2)MeSbO(6) on YBCO, A(2)MeSbO(6)/(001) YBCO/(100) MgO by pulsed-laser ablation. C1 USA,RES LAB,PHYS SCI DIRECTORATE,FT MONMOUTH,NJ 07703. RI Tidrow, Steven/C-8133-2013 NR 12 TC 17 Z9 17 U1 0 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0921-4534 J9 PHYSICA C JI Physica C PD JAN 10 PY 1996 VL 256 IS 3-4 BP 340 EP 344 DI 10.1016/0921-4534(95)00661-3 PG 5 WC Physics, Applied SC Physics GA TT017 UT WOS:A1996TT01700017 ER PT J AU McGuire, WP Hoskins, WJ Brady, MF Kucera, PR Partridge, EE Look, KY ClarkePearson, DL Davidson, M AF McGuire, WP Hoskins, WJ Brady, MF Kucera, PR Partridge, EE Look, KY ClarkePearson, DL Davidson, M TI Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with stage III and stage IV ovarian cancer SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID RANDOMIZED TRIAL; COMBINATION CHEMOTHERAPY; FOLLOW-UP; CARCINOMA; TAXOL; DOXORUBICIN AB Background. Chemotherapy combinations that include an alkylating agent and a platinum coordination complex have high response rates in women with advanced ovarian cancer. Such combinations provide longterm control of disease in few patients, however. We compared two combinations, cisplatin and cyclophosphamide and cisplatin and paclitaxel, in women with ovarian cancer. Methods. We randomly assigned 410 women with advanced ovarian cancer and residual masses larger than 1 cm after initial surgery to receive cisplatin (75 mg per square meter of body-surface area) with either cyclophosphamide (750 mg per square meter) or paclitaxel (135 mg per square meter over a period of 24 hours). Results. Three hundred eighty-six women met all the eligibility criteria. Known prognostic factors were similar in the two treatment groups. Alopecia, neutropenia, fever, and allergic reactions were reported more frequently in the cisplatin-paclitaxel group. Among 216 women with measurable disease, 73 percent in the cisplatin-paclitaxel group responded to therapy, as compared with 60 percent in the cisplatin-cyclophosphamide group (P=0.01), The frequency of surgically verified complete response was similar in the two groups, Progression-free survival was significantly longer (P<0.001) in the cisplatin-paclitaxel group than in the cisplatin-cyclophosphamide group (median, 18 vs, 13 months), Survival was also significantly longer (P<0.001) in the cisplatin-paclitaxel group (median, 38 vs. 24 months). Conclusions. Incorporating paclitaxel into first-line therapy improves the duration of progression-free survival and of overall survival in women with incompletely resected stage III and stage IV ovarian cancer. (C) 1996, Massachusetts Medical Society. C1 EMORY UNIV,DEPT MED,ATLANTA,GA 30322. MEM SLOAN KETTERING CANC CTR,DEPT SURG,GYNECOL SERV,NEW YORK,NY 10021. CORNELL UNIV,COLL MED,DEPT OBSTET & GYNECOL,NEW YORK,NY. ROSWELL PK CANC INST,GYNECOL ONCOL GRP STAT OFF,BUFFALO,NY. OREGON HLTH SCI UNIV,DEPT OBSTET & GYNECOL,DIV GYNECOL ONCOL,PORTLAND,OR. UNIV ALABAMA,DEPT OBSTET & GYNECOL,DIV GYNECOL ONCOL,BIRMINGHAM,AL. INDIANA UNIV,SCH MED,DIV OBSTET & GYNECOL,INDIANAPOLIS,IN. DUKE UNIV,SCH MED,DEPT OBSTET & GYNECOL,DIV GYNECOL ONCOL,DURHAM,NC. WALTER REED ARMY MED CTR,DEPT PATHOL & AREA LAB SCI,WASHINGTON,DC 20307. FU NCI NIH HHS [CA 27469, CA 37517] NR 26 TC 2112 Z9 2155 U1 18 U2 85 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD JAN 4 PY 1996 VL 334 IS 1 BP 1 EP 6 DI 10.1056/NEJM199601043340101 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA TM482 UT WOS:A1996TM48200001 PM 7494563 ER PT B AU Damarla, TR Chung, MJ Su, W Michael, GT AF Damarla, TR Chung, MJ Su, W Michael, GT GP IEEE TI Faulty chip identification in a multi-chip module system SO 14TH IEEE VLSI TEST SYMPOSIUM, PROCEEDINGS LA English DT Proceedings Paper CT 14th IEEE VLSI Test Symposium CY APR 28-MAY 01, 1996 CL PRINCETON, NJ SP IEEE, Comp Soc, Tech Comm Test Technol, IEEE, Philadelphia Sect C1 USA,NATL RES COUNCIL,RES LABS,AMRSL,PS,EA,FT MONMOUTH,NJ 07703. NR 0 TC 1 Z9 1 U1 0 U2 0 PU I E E E, COMPUTER SOC PRESS PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, LOS ALAMITOS, CA 90720 BN 0-8186-7304-4 PY 1996 BP 254 EP 259 DI 10.1109/VTEST.1996.510865 PG 6 WC Computer Science, Hardware & Architecture; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BF75X UT WOS:A1996BF75X00038 ER PT B AU Buckstad, RD Samuda, EF AF Buckstad, RD Samuda, EF GP AIAA/IEEE TI US Army digitization and open architectures for avionics SO 15TH DASC - AIAA/IEEE DIGITAL AVIONICS SYSTEMS CONFERENCE LA English DT Proceedings Paper CT 15th AIAA/IEEE Digital Avionics Systems Conference (15th DASC) CY OCT 27-31, 1996 CL ATLANTA, GA SP AIAA, IEEE RP Buckstad, RD (reprint author), USA,WASHINGTON,DC 20310, USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU I E E E PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 BN 0-7803-3386-1 PY 1996 BP 199 EP 204 DI 10.1109/DASC.1996.559159 PG 6 WC Engineering, Aerospace SC Engineering GA BG78Z UT WOS:A1996BG78Z00028 ER PT B AU McGarrity, JM Scozzie, CJ Blackburn, J DeLancey, WM AF McGarrity, JM Scozzie, CJ Blackburn, J DeLancey, WM BE Moonier, PA TI High temperature silicon carbide FETs for radiation environments SO 1995 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE RECORD, VOLS 1-3 LA English DT Proceedings Paper CT 1995 IEEE Nuclear Science Symposium and Medical Imaging Conference CY OCT 21-28, 1995 CL SAN FRANCISCO, CA SP IEEE C1 USA,RES LAB,ADELPHI,MD 20783. NR 0 TC 0 Z9 0 U1 1 U2 1 PU I E E E PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 BN 0-7803-3181-8 PY 1996 BP 144 EP 147 PG 4 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Instruments & Instrumentation; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA BF95Z UT WOS:A1996BF95Z00033 ER PT B AU Swami, A Sadler, B AF Swami, A Sadler, B BE Lervik, JM Waldemar, P TI Fast estimation of higher-order moments using sign bit and reference signals SO 1996 IEEE DIGITAL SIGNAL PROCESSING WORKSHOP, PROCEEDINGS LA English DT Proceedings Paper CT 1996 IEEE Digital Signal Processing Workshop (DSPWS-96) CY SEP 01-04, 1996 CL LOEN, NORWAY SP IEEE, NORSIG, ABB Technol, NERA C1 USA,RES LAB,AMSRL,IS,TA,ADELPHI,MD 20783. NR 0 TC 0 Z9 0 U1 0 U2 0 PU I E E E PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 BN 0-7803-3629-1 PY 1996 BP 315 EP 318 DI 10.1109/DSPWS.1996.555524 PG 4 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA BG39X UT WOS:A1996BG39X00080 ER PT B AU Hollis, HD Arno, RG Briggs, SJ Hale, PS AF Hollis, HD Arno, RG Briggs, SJ Hale, PS GP IEEE TI Operational maintenance data for power generation distribution and HVAC components SO 1996 IEEE INDUSTRIAL AND COMMERCIAL POWER SYSTEMS TECHNICAL CONFERENCE, CONFERENCE RECORD LA English DT Proceedings Paper CT 1996 IEEE Industrial and Commercial Power Systems Technical Conference CY MAY 06-09, 1996 CL NEW ORLEANS, LA SP IEEE, Ind Applicat Soc, Ind & Commercial Power Syst Dept, IEEE, New Orleans C1 USA,CTR PUBL WORKS,POWER RELIABIL ENHANCEMENT PROGRAM,FT BELVOIR,VA 22315. NR 0 TC 0 Z9 0 U1 0 U2 0 PU I E E E PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 BN 0-7803-3264-4 PY 1996 BP 5 EP 21 PG 17 WC Engineering, Electrical & Electronic SC Engineering GA BF75R UT WOS:A1996BF75R00002 ER PT B AU Sadler, BM Casey, SD AF Sadler, BM Casey, SD GP IEEE TI Frequency estimation via sparse zero crossings SO 1996 IEEE INTERNATIONAL CONFERENCE ON ACOUSTICS, SPEECH, AND SIGNAL PROCESSING, CONFERENCE PROCEEDINGS, VOLS 1-6 LA English DT Proceedings Paper CT 1996 IEEE International Conference on Acoustics, Speech, and Signal Processing (ICASSP 96) CY MAY 07-10, 1996 CL ATLANTA, GA SP IEEE, Signal Proc Soc C1 USA,RES LAB,ADELPHI,MD 20783. NR 0 TC 0 Z9 0 U1 0 U2 1 PU I E E E PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 BN 0-7803-3192-3 J9 INT CONF ACOUST SPEE PY 1996 BP 2990 EP 2993 PG 4 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA BG26G UT WOS:A1996BG26G00755 ER PT S AU George, R Kanayama, Y AF George, R Kanayama, Y GP IEEE, ROBOT & AUTOMAT SOC TI A rate-monotonic scheduler for the real-time control of autonomous robots SO 1996 IEEE INTERNATIONAL CONFERENCE ON ROBOTICS AND AUTOMATION, PROCEEDINGS, VOLS 1-4 SE IEEE INTERNATIONAL CONFERENCE ON ROBOTICS AND AUTOMATION LA English DT Proceedings Paper CT 1996 IEEE International Conference on Robotics and Automation CY APR 22-28, 1996 CL MINNEAPOLIS, MN SP IEEE, Robot & Automat Soc C1 USA,RES LAB,INFORMAT SCI DIRECTORATE,ADELPHI,MD 20783. NR 0 TC 3 Z9 6 U1 0 U2 0 PU I E E E PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 1050-4729 BN 0-7803-2989-9 J9 IEEE INT CONF ROBOT PY 1996 BP 2804 EP 2809 PG 6 WC Automation & Control Systems SC Automation & Control Systems GA BF68P UT WOS:A1996BF68P00440 ER PT S AU Paolella, A Tait, G Cooke, P Nabet, B Tousley, B AF Paolella, A Tait, G Cooke, P Nabet, B Tousley, B BE Ranson, RG Pollard, RD TI Metal-semiconductor-metal photodetectors on intermediate temperature MBE grown GaAs for lightwave/millimeter-wave applications SO 1996 IEEE MTT-S INTERNATIONAL MICROWAVE SYMPOSIUM DIGEST, VOLS 1-3 SE IEEE MTT-S INTERNATIONAL MICROWAVE SYMPOSIUM DIGEST LA English DT Proceedings Paper CT 1996 IEEE MTT-S International Microwave Symposium CY JUN 17-21, 1996 CL SAN FRANCISCO, CA SP IEEE, MTT Soc C1 USA,CECOM,RES DEV & ENGN CTR,FT MONMOUTH,NJ 07703. NR 0 TC 0 Z9 0 U1 0 U2 0 PU I E E E PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 0149-645X BN 0-7803-3247-4 J9 IEEE MTT-S PY 1996 BP 915 EP 918 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA BF95U UT WOS:A1996BF95U00212 ER PT S AU Sturzebecher, D Leen, J Cadotte, R DeMarco, J Ni, TD Higgins, T Popick, M Cummings, M VanMeerbeke, B Provencher, T Kimble, B Shalkhauser, K Simons, R AF Sturzebecher, D Leen, J Cadotte, R DeMarco, J Ni, TD Higgins, T Popick, M Cummings, M VanMeerbeke, B Provencher, T Kimble, B Shalkhauser, K Simons, R BE Ranson, RG Pollard, RD TI 20 GHz LTCC phased array module SO 1996 IEEE MTT-S INTERNATIONAL MICROWAVE SYMPOSIUM DIGEST, VOLS 1-3 SE IEEE MTT-S INTERNATIONAL MICROWAVE SYMPOSIUM DIGEST LA English DT Proceedings Paper CT 1996 IEEE MTT-S International Microwave Symposium CY JUN 17-21, 1996 CL SAN FRANCISCO, CA SP IEEE, MTT Soc C1 USA,RES LAB,PHYS SCI DIRECTORATE,FT MONMOUTH,NJ. NR 0 TC 2 Z9 2 U1 0 U2 0 PU I E E E PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 0149-645X BN 0-7803-3247-4 J9 IEEE MTT-S PY 1996 BP 991 EP 994 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA BF95U UT WOS:A1996BF95U00231 ER PT S AU Funk, EE Saddow, SE Jasper, LJ Lee, CH AF Funk, EE Saddow, SE Jasper, LJ Lee, CH BE Ranson, RG Pollard, RD TI Optically controlled spread-spectrum RF data link SO 1996 IEEE MTT-S INTERNATIONAL MICROWAVE SYMPOSIUM DIGEST, VOLS 1-3 SE IEEE MTT-S INTERNATIONAL MICROWAVE SYMPOSIUM DIGEST LA English DT Proceedings Paper CT 1996 IEEE MTT-S International Microwave Symposium CY JUN 17-21, 1996 CL SAN FRANCISCO, CA SP IEEE, MTT Soc C1 USA,RES LAB,ADELPHI,MD 20783. NR 0 TC 0 Z9 0 U1 1 U2 1 PU I E E E PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 0149-645X BN 0-7803-3247-4 J9 IEEE MTT-S PY 1996 BP 1563 EP 1566 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA BF95U UT WOS:A1996BF95U00364 ER PT S AU Ni, TD DeMarco, J Sturzebecher, D Cummings, M AF Ni, TD DeMarco, J Sturzebecher, D Cummings, M BE Ranson, RG Pollard, RD TI High frequency hermetic packages using LTCC SO 1996 IEEE MTT-S INTERNATIONAL MICROWAVE SYMPOSIUM DIGEST, VOLS 1-3 SE IEEE MTT-S INTERNATIONAL MICROWAVE SYMPOSIUM DIGEST LA English DT Proceedings Paper CT 1996 IEEE MTT-S International Microwave Symposium CY JUN 17-21, 1996 CL SAN FRANCISCO, CA SP IEEE, MTT Soc C1 USA,RES LAB,PHYS SCI DIRECTORATE,AMSRL,PS,EB,FT MONMOUTH,NJ 07703. NR 0 TC 0 Z9 1 U1 0 U2 0 PU I E E E PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 0149-645X BN 0-7803-3247-4 J9 IEEE MTT-S PY 1996 BP 1627 EP 1630 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA BF95U UT WOS:A1996BF95U00379 ER PT S AU Kaul, R AF Kaul, R BE Ranson, RG Pollard, RD TI Observations of chaos in microwave circuits SO 1996 IEEE MTT-S INTERNATIONAL MICROWAVE SYMPOSIUM DIGEST, VOLS 1-3 SE IEEE MTT-S INTERNATIONAL MICROWAVE SYMPOSIUM DIGEST LA English DT Proceedings Paper CT 1996 IEEE MTT-S International Microwave Symposium CY JUN 17-21, 1996 CL SAN FRANCISCO, CA SP IEEE, MTT Soc C1 USA,RES LAB,ADELPHI,MD 20783. NR 0 TC 0 Z9 0 U1 0 U2 0 PU I E E E PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 0149-645X BN 0-7803-3247-4 J9 IEEE MTT-S PY 1996 BP 1867 EP 1870 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA BF95U UT WOS:A1996BF95U00439 ER PT S AU Hayes, S Grebogi, C AF Hayes, S Grebogi, C BE Ranson, RG Pollard, RD TI Using controlled chaos for digital signaling: A physical principle for 1-stage waveform synthesis SO 1996 IEEE MTT-S INTERNATIONAL MICROWAVE SYMPOSIUM DIGEST, VOLS 1-3 SE IEEE MTT-S INTERNATIONAL MICROWAVE SYMPOSIUM DIGEST LA English DT Proceedings Paper CT 1996 IEEE MTT-S International Microwave Symposium CY JUN 17-21, 1996 CL SAN FRANCISCO, CA SP IEEE, MTT Soc C1 USA,RES LAB,ADELPHI,MD 20783. NR 0 TC 1 Z9 1 U1 1 U2 1 PU I E E E PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 0149-645X BN 0-7803-3247-4 J9 IEEE MTT-S PY 1996 BP 1879 EP 1882 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA BF95U UT WOS:A1996BF95U00442 ER PT B AU Ni, TD Sturzebecher, D AF Ni, TD Sturzebecher, D GP IEEE TI Polymer optical couplers for applications in multi-chip modules SO 1996 IEEE MULTI-CHIP MODULE CONFERENCE, PROCEEDINGS LA English DT Proceedings Paper CT 1996 IEEE Multi-Chip Module Conference CY FEB 06-07, 1996 CL SANTA CRUZ, CA SP IEEE Circuits & Syst Soc, IEEE Components Packaging & Mfg Technol Soc, IEEE Electron Devices Soc, IEEE Comp Soc, IEEE Comp Soc Tech Comm VLSI C1 USA,RES LAB,PHYS SCI DIRECTORATE,FT MONMOUTH,NJ 07703. NR 0 TC 0 Z9 0 U1 0 U2 0 PU I E E E, COMPUTER SOC PRESS PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, LOS ALAMITOS, CA 90720 BN 0-8186-7286-2 PY 1996 BP 178 EP 181 DI 10.1109/MCMC.1996.510791 PG 4 WC Computer Science, Hardware & Architecture; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BF12Y UT WOS:A1996BF12Y00033 ER PT S AU Ballato, A AF Ballato, A BE Levy, M Schneider, SC McAvoy, BR TI Piezoelectricity: History and new thrusts SO 1996 IEEE ULTRASONICS SYMPOSIUM, PROCEEDINGS, VOLS 1 AND 2 SE ULTRASONICS SYMPOSIUM LA English DT Proceedings Paper CT 1996 IEEE Ultrasonic Symposium CY NOV 03-06, 1996 CL SAN ANTONIO, TX SP IEEE Ultrason Ferroelect & Frequency Control Soc AB Piezoelectricity was discovered by the brothers Curie in 1880. What started out as a scientific curiosity has grown to have very significant commercial importance. We sketch here some of the milestones of its history, a bit of its phenomenology, and conclude with some present applications and prospects for the future. RP Ballato, A (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 0 TC 0 Z9 0 U1 1 U2 5 PU I E E E PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 1051-0117 BN 0-7803-3615-1 J9 ULTRASON PY 1996 BP 575 EP 583 PG 9 WC Acoustics; Engineering, Electrical & Electronic; Physics, Applied; Polymer Science SC Acoustics; Engineering; Physics; Polymer Science GA BH56C UT WOS:A1996BH56C00118 ER PT S AU Abbate, A Frankel, J Reed, RW Das, P AF Abbate, A Frankel, J Reed, RW Das, P BE Levy, M Schneider, SC McAvoy, BR TI Wavelet image processing for wear and erosion mapping using an ultrasonic gauging technique SO 1996 IEEE ULTRASONICS SYMPOSIUM, PROCEEDINGS, VOLS 1 AND 2 SE ULTRASONICS SYMPOSIUM LA English DT Proceedings Paper CT 1996 IEEE Ultrasonic Symposium CY NOV 03-06, 1996 CL SAN ANTONIO, TX SP IEEE Ultrason Ferroelect & Frequency Control Soc AB A wavelet transform image decomposition technique was developed for compression and analysis of the ultrasonic images resulting in a great decrease in time and resources. The data is generated by a Computerized Ultrasonic Gauging System (CUGS) recently developed which using time delay measurements generates very precise topographical maps of the outer and inner surfaces of tubes during the various stages of manufacture. The dimensions of the part are displayed as images. The wavelet technique here presented is utilized to evaluate wear and erosion patterns measured before and after exposure to enviroments involving extreme temperature, pressure, corrosive gases and mechanical forces. RP Abbate, A (reprint author), USA,TANK AUTOMOT ARMAMENTS COMMAND,BENET LABS,AMSTA,AR,CCB,TA,WATERVLIET,NY 12189, USA. RI Abbate, Antonio/G-8805-2016 OI Abbate, Antonio/0000-0002-1930-785X NR 0 TC 0 Z9 0 U1 0 U2 0 PU I E E E PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 1051-0117 BN 0-7803-3615-1 J9 ULTRASON PY 1996 BP 705 EP 708 PG 4 WC Acoustics; Engineering, Electrical & Electronic; Physics, Applied; Polymer Science SC Acoustics; Engineering; Physics; Polymer Science GA BH56C UT WOS:A1996BH56C00144 ER PT S AU Kosinski, JA Lu, YC Ballato, A AF Kosinski, JA Lu, YC Ballato, A BE Levy, M Schneider, SC McAvoy, BR TI Field steering of lateral-field excitation SO 1996 IEEE ULTRASONICS SYMPOSIUM, PROCEEDINGS, VOLS 1 AND 2 SE ULTRASONICS SYMPOSIUM LA English DT Proceedings Paper CT 1996 IEEE Ultrasonic Symposium CY NOV 03-06, 1996 CL SAN ANTONIO, TX SP IEEE Ultrason Ferroelect & Frequency Control Soc AB A 'conventional' lateral-field excitation (LE) electrode consists of a single pair of segments separated by a narrow gap. The LE resonator parameters are then fixed at values determined by the orientation of the gap. The limitations of fixed field orientation can be overcome by using a Multiple Segmented Lateral-Field Excitation (MuSLE) electrode. This electrode differs from the 'conventional' case in the further segmentation of the driving electrode through the addition of a second gap perpendicular to the first. By so doing, it is possible to add a second component to the driving electric field, thus allowing the field orientation to be adjusted. This 'field steering' enables one to adjust a) the strengths with which the thickness modes are excited and b) the LE antiresonance frequencies. These effects provide a postproduction means to optimize the performance of an LE resonator. The use of field steering also enables new possibilities in shear wave transducer design. RP Kosinski, JA (reprint author), USA,CECOM,FT MONMOUTH,NJ 07703, USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU I E E E PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 1051-0117 BN 0-7803-3615-1 J9 ULTRASON PY 1996 BP 987 EP 990 PG 4 WC Acoustics; Engineering, Electrical & Electronic; Physics, Applied; Polymer Science SC Acoustics; Engineering; Physics; Polymer Science GA BH56C UT WOS:A1996BH56C00205 ER PT S AU Abbate, A Cox, JF Schroeder, SC Knight, B Frankel, J AF Abbate, A Cox, JF Schroeder, SC Knight, B Frankel, J BE Levy, M Schneider, SC McAvoy, BR TI Rayleigh velocities for the evaluation of coating hardness SO 1996 IEEE ULTRASONICS SYMPOSIUM, PROCEEDINGS, VOLS 1 AND 2 SE ULTRASONICS SYMPOSIUM LA English DT Proceedings Paper CT 1996 IEEE Ultrasonic Symposium CY NOV 03-06, 1996 CL SAN ANTONIO, TX SP IEEE Ultrason Ferroelect & Frequency Control Soc AB The Rayleigh or surface wave velocity in a metallic coating electro-deposited on steel was measured and an experimental correlation was found between the velocity and the hardness of the coating. Since qualitative coating properties are commonly inferred from hardness tests, this result suggests the utilization of nondestructive surface ultrasonic velocity measurements to evaluate the coating hardness over regions which are inaccessible to conventional hardness tests, or where it is not possible to allow a hardness indentation. Here we propose a nondestructive ultrasonic technique to evaluate the hardness of electrodeposited chromium coatings, based on the empirical relationship we have relating hardness and Rayleigh velocity. In view of available experimental evidence of the relationship between surface hardness and Rayleigh velocity in other bulk metals this relationship should be investigated in other coatings as well. RP Abbate, A (reprint author), USA,TANK AUTOMOT ARMAMENTS COMMAND,BENET LABS,TA,CCB,AR,AMSTA,WATERVLIET,NY 12189, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU I E E E PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 1051-0117 BN 0-7803-3615-1 J9 ULTRASON PY 1996 BP 1017 EP 1020 PG 4 WC Acoustics; Engineering, Electrical & Electronic; Physics, Applied; Polymer Science SC Acoustics; Engineering; Physics; Polymer Science GA BH56C UT WOS:A1996BH56C00212 ER PT B AU Barto, JC Clark, PD AF Barto, JC Clark, PD BE Charnes, JM Morrice, DJ Brunner, DT Swain, JJ TI The joint training system: A pillar of joint readiness and an automation challenge SO 1996 WINTER SIMULATION CONFERENCE PROCEEDINGS LA English DT Proceedings Paper CT 1996 Winter Simulation Conference (WSC 96) CY DEC 08-11, 1996 CL CORONADO, CA SP Amer Stat Assoc, Assoc Comp Machinery, SIGSIM, Inst Operat Res & Management Sci, Inst Operat Res & Management Sci, Coll Simulat, IEEE Comp Soc, IEEE Syst Man & Cybernet Soc, Inst Ind Engineers, NIST, Soc Comp Simulat Int AB The Joint Training System (JTS) (Figure 1) defines a multi-step approach to identify training requirements, plan, execute, and assess joint training events. First, and foremost, the JTS is focused on warfighting. ''The specific objective is to develop a joint training program that bolsters the combatant commanders' ability to execute the National Military Strategy while simultaneously maintaining high readiness of our forces as a pre-requisite to deterring aggression and responding to crisis. The desired end state is the improved readiness of joint forces, a training and exercise strategy better aligned with the National Military Strategy, improved interoperability, and a more stable process for optimizing the application of scarce resources (dollars, forces, time).'' Successful implementation of the JTS depends upon automating the system's processes so that the development, sharing, and reporting of training information and products is conducted as efficiently and effectively as possible. RP Barto, JC (reprint author), USA,JOINT WARFIGHTING CTR,FT MONROE,VA 23651, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU I E E E PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 BN 0-7803-3383-7 PY 1996 BP 871 EP 876 PG 6 WC Computer Science, Cybernetics; Engineering, Industrial; Engineering, Manufacturing; Engineering, Electrical & Electronic; Statistics & Probability SC Computer Science; Engineering; Mathematics GA BH19F UT WOS:A1996BH19F00124 ER PT B AU Phelan, RG McGinnis, ML AF Phelan, RG McGinnis, ML BE Charnes, JM Morrice, DJ Brunner, DT Swain, JJ TI Reengineering the United States Army's tactical command and control operational architecture for information operations SO 1996 WINTER SIMULATION CONFERENCE PROCEEDINGS LA English DT Proceedings Paper CT 1996 Winter Simulation Conference (WSC 96) CY DEC 08-11, 1996 CL CORONADO, CA SP Amer Stat Assoc, Assoc Comp Machinery, SIGSIM, Inst Operat Res & Management Sci, Inst Operat Res & Management Sci, Coll Simulat, IEEE Comp Soc, IEEE Syst Man & Cybernet Soc, Inst Ind Engineers, NIST, Soc Comp Simulat Int AB During the past few years, the Army has undertaken a major effort to integrate computer, information, and communication technologies throughout the force. These technologies have made a profound impact on the Army's tactical command and control (C-2) processes,especially at division and below. This paper presents a computer simulation model to support the reengineering of the United States Army's staff organization at division and below for information operations. The simulation model under development will provide force planners with a tool for methodically conducting comparative analyses of specific alternatives for reengineering tactical level Army staffs to improve efficiency and effectiveness of staff work related to information operations. RP Phelan, RG (reprint author), US MIL ACAD,CTR OPERAT RES,W POINT,NY 10996, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU I E E E PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 BN 0-7803-3383-7 PY 1996 BP 918 EP 925 PG 8 WC Computer Science, Cybernetics; Engineering, Industrial; Engineering, Manufacturing; Engineering, Electrical & Electronic; Statistics & Probability SC Computer Science; Engineering; Mathematics GA BH19F UT WOS:A1996BH19F00132 ER PT B AU Kwinn, MJ Phelan, RG AF Kwinn, MJ Phelan, RG BE Charnes, JM Morrice, DJ Brunner, DT Swain, JJ TI Management of personnel policies to increase the stability of patriot crew members and their families: A simulation approach SO 1996 WINTER SIMULATION CONFERENCE PROCEEDINGS LA English DT Proceedings Paper CT 1996 Winter Simulation Conference (WSC 96) CY DEC 08-11, 1996 CL CORONADO, CA SP Amer Stat Assoc, Assoc Comp Machinery, SIGSIM, Inst Operat Res & Management Sci, Inst Operat Res & Management Sci, Coll Simulat, IEEE Comp Soc, IEEE Syst Man & Cybernet Soc, Inst Ind Engineers, NIST, Soc Comp Simulat Int AB The overwhelming success of the Patriot Air Defense weapon system during Operation Desert Storm has become a double edge sword for the system's enlisted crew members and their families. During the war, the Patriot system became the First proven means of defending against Tactical Ballistic Missile (TBM) attacks. The people and the governments of Israel, Saudi Arabia and the United Stales praised the Pat-riot crew members as true heroes. Unfortunately for the Patriot crew members, their success also meant that every country wanted the protection that the system offered. A battalion is now permanently stationed in Korea. Another battalion rotates every six months to Saudi Arabia. The increased number of deployments of the system and the crew members has had dramatically negative impact on morale, retention and recruitment of Patriot crew members. In this paper, we present a simulation model which allows a personnel manager to vary personnel policies effecting Patriot crew members to determine the impact an the number and frequency of deployments and on unit readiness. RP Kwinn, MJ (reprint author), US MIL ACAD,DEPT SYST ENGN,W POINT,NY 10996, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU I E E E PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 BN 0-7803-3383-7 PY 1996 BP 926 EP 933 PG 8 WC Computer Science, Cybernetics; Engineering, Industrial; Engineering, Manufacturing; Engineering, Electrical & Electronic; Statistics & Probability SC Computer Science; Engineering; Mathematics GA BH19F UT WOS:A1996BH19F00133 ER PT B AU McGinnis, ML Stone, GF AF McGinnis, ML Stone, GF BE Charnes, JM Morrice, DJ Brunner, DT Swain, JJ TI Measuring the effectiveness of simulation-based training SO 1996 WINTER SIMULATION CONFERENCE PROCEEDINGS LA English DT Proceedings Paper CT 1996 Winter Simulation Conference (WSC 96) CY DEC 08-11, 1996 CL CORONADO, CA SP Amer Stat Assoc, Assoc Comp Machinery, SIGSIM, Inst Operat Res & Management Sci, Inst Operat Res & Management Sci, Coll Simulat, IEEE Comp Soc, IEEE Syst Man & Cybernet Soc, Inst Ind Engineers, NIST, Soc Comp Simulat Int AB The relationship between measures of training performance and the achievement of training goals is often difficult to quantify. This continues to be an obstacle to the development of curricula for simulation-based training systems. These include both constructive and virtual computer simulations for training. This paper discusses the development of training effectiveness measures as they relate to the design of instructional, simulation-based training systems featuring automated tools for planning training. RP McGinnis, ML (reprint author), US MIL ACAD,DEPT SYST ENGN,CTR OPERAT RES,W POINT,NY 10996, USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU I E E E PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 BN 0-7803-3383-7 PY 1996 BP 934 EP 938 PG 5 WC Computer Science, Cybernetics; Engineering, Industrial; Engineering, Manufacturing; Engineering, Electrical & Electronic; Statistics & Probability SC Computer Science; Engineering; Mathematics GA BH19F UT WOS:A1996BH19F00134 ER PT B AU Rachele, H Tunick, AD Kordova, L Mahrer, Y AF Rachele, H Tunick, AD Kordova, L Mahrer, Y GP AMER METEOROL SOC TI A radiation and energy balance model for the microscale - Surface layer environment SO 22ND CONFERENCE ON AGRICULTURAL & FOREST METEOROLOGY WITH SYMPOSIUM ON FIRE & FOREST METEOROLOGY/12TH CONFERENCE ON BIOMETEOROLOGY & AEROBIOLOGY LA English DT Proceedings Paper CT 22nd Conference on Agricultural and Forest Meteorology with Symposium on Fire and Forest Meteorology/12th Conference on Biometeorology and Aerobiology CY JAN 28-FEB 02, 1996 CL ATLANTA, GA SP Amer Meteorol Soc C1 USA,RES LAB,BATTLEFIELD ENVIRONM DIRECTORATE,WHITE SANDS MISSILE RANGE,NM 88002. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108 PY 1996 BP 206 EP 209 PG 4 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA BF44H UT WOS:A1996BF44H00064 ER PT B AU Cionco, RM Miller, DR AF Cionco, RM Miller, DR GP AMER METEOROL SOC TI Behavior of wind fields through tree stand edges SO 22ND CONFERENCE ON AGRICULTURAL & FOREST METEOROLOGY WITH SYMPOSIUM ON FIRE & FOREST METEOROLOGY/12TH CONFERENCE ON BIOMETEOROLOGY & AEROBIOLOGY LA English DT Proceedings Paper CT 22nd Conference on Agricultural and Forest Meteorology with Symposium on Fire and Forest Meteorology/12th Conference on Biometeorology and Aerobiology CY JAN 28-FEB 02, 1996 CL ATLANTA, GA SP Amer Meteorol Soc C1 USA,RES LAB,WHITE SANDS MISSILE RANGE,NM 88002. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108 PY 1996 BP 381 EP 382 PG 2 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA BF44H UT WOS:A1996BF44H00115 ER PT B AU Cionco, RM Ellefsen, R AF Cionco, RM Ellefsen, R GP AMER METEOROL SOC TI High resolution urban morphology data for urban flow modeling SO 22ND CONFERENCE ON AGRICULTURAL & FOREST METEOROLOGY WITH SYMPOSIUM ON FIRE & FOREST METEOROLOGY/12TH CONFERENCE ON BIOMETEOROLOGY & AEROBIOLOGY LA English DT Proceedings Paper CT 22nd Conference on Agricultural and Forest Meteorology with Symposium on Fire and Forest Meteorology/12th Conference on Biometeorology and Aerobiology CY JAN 28-FEB 02, 1996 CL ATLANTA, GA SP Amer Meteorol Soc C1 USA,RES LAB,WHITE SANDS MISSILE RANGE,NM 88002. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108 PY 1996 BP 447 EP 450 PG 4 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA BF44H UT WOS:A1996BF44H00134 ER PT B AU Cionco, RM Byers, JH AF Cionco, RM Byers, JH GP AMER METEOROL SOC TI Simulating airflow within and above a geometrically uniform canopy SO 22ND CONFERENCE ON AGRICULTURAL & FOREST METEOROLOGY WITH SYMPOSIUM ON FIRE & FOREST METEOROLOGY/12TH CONFERENCE ON BIOMETEOROLOGY & AEROBIOLOGY LA English DT Proceedings Paper CT 22nd Conference on Agricultural and Forest Meteorology with Symposium on Fire and Forest Meteorology/12th Conference on Biometeorology and Aerobiology CY JAN 28-FEB 02, 1996 CL ATLANTA, GA SP Amer Meteorol Soc C1 USA,RES LAB,WHITE SANDS MISSILE RANGE,NM 88002. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108 PY 1996 BP J99 EP J100 PG 2 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA BF44H UT WOS:A1996BF44H00176 ER PT S AU vanHamont, JE Madden, EF Mood, BA Jacob, E Setterstrom, JA AF vanHamont, JE Madden, EF Mood, BA Jacob, E Setterstrom, JA GP CONTROLLED RELEASE SOC TI Evaluation of solvent extraction and solvent evaporation procedures for production of tobramycin-releasing microspheres SO 23RD INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, 1996 PROCEEDINGS SE CONTROLLED RELEASE SOCIETY. INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS LA English DT Proceedings Paper CT 23rd International Symposium on Controlled Release of Bioactive Materials CY JUL 07-10, 1996 CL KYOTO, JAPAN SP Controlled Release Soc Inc, Japan Soc Drug Delivery Syst RP vanHamont, JE (reprint author), USA,DENT RES DETACHMENT,FT GEORGE G MEADE,MD 20755, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU CONTROLLED RELEASE SOCIETY INC PI DEERFIELD PA 1020 MILWAUKEE AVE SUITE 235, DEERFIELD, IL 60015 SN 1022-0178 J9 CRS BUI NAT PY 1996 BP 365 EP 366 PG 2 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA BH42C UT WOS:A1996BH42C00186 ER PT S AU Vaughan, WM Duong, HN Blackman, KP Wood, BA Setterstrom, JA vanHamont, JE AF Vaughan, WM Duong, HN Blackman, KP Wood, BA Setterstrom, JA vanHamont, JE GP CONTROLLED RELEASE SOC TI Formulation of lidocaine-PLGA microspheres for the treatment of dental pain SO 23RD INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, 1996 PROCEEDINGS SE CONTROLLED RELEASE SOCIETY. INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS LA English DT Proceedings Paper CT 23rd International Symposium on Controlled Release of Bioactive Materials CY JUL 07-10, 1996 CL KYOTO, JAPAN SP Controlled Release Soc Inc, Japan Soc Drug Delivery Syst RP Vaughan, WM (reprint author), USA,DENT RES DETACHMENT,FT GEORGE G MEADE,MD 20755, USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU CONTROLLED RELEASE SOCIETY INC PI DEERFIELD PA 1020 MILWAUKEE AVE SUITE 235, DEERFIELD, IL 60015 SN 1022-0178 J9 CRS BUI NAT PY 1996 BP 375 EP 376 PG 2 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA BH42C UT WOS:A1996BH42C00191 ER PT J AU Kende, M Yan, C Rill, W Tammariello, R Heller, J Liu, LS AF Kende, M Yan, C Rill, W Tammariello, R Heller, J Liu, LS GP CONTROLLED RELEASE SOC TI Immunization with ricin toxoid vaccine incorporated in macroporous alginate/chitosan hydrogel microspheres SO 23RD INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, 1996 PROCEEDINGS SE CONTROLLED RELEASE SOCIETY. INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS LA English DT Proceedings Paper CT 23rd International Symposium on Controlled Release of Bioactive Materials CY JUL 07-10, 1996 CL KYOTO, JAPAN SP Controlled Release Soc Inc, Japan Soc Drug Delivery Syst RP Kende, M (reprint author), USA,MED RES INST INFECT DIS,FT DETRICK,MD 21702, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CONTROLLED RELEASE SOCIETY INC PI DEERFIELD PA 1020 MILWAUKEE AVE SUITE 235, DEERFIELD, IL 60015 SN 1022-0178 J9 CRS BUI NAT PY 1996 BP 715 EP 716 PG 2 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA BH42C UT WOS:A1996BH42C00361 ER PT J AU Yan, CH Kende, M Liu, LS AF Yan, CH Kende, M Liu, LS GP CONTROLLED RELEASE SOC TI Controlled release of protein from blends of poly(lactide-co-ethylene glycol) and poly(ethylene glycol) SO 23RD INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, 1996 PROCEEDINGS SE CONTROLLED RELEASE SOCIETY. INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS LA English DT Proceedings Paper CT 23rd International Symposium on Controlled Release of Bioactive Materials CY JUL 07-10, 1996 CL KYOTO, JAPAN SP Controlled Release Soc Inc, Japan Soc Drug Delivery Syst RP Yan, CH (reprint author), USA,MED RES INST INFECT DIS,FT DETRICK,MD 21702, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CONTROLLED RELEASE SOCIETY INC PI DEERFIELD PA 1020 MILWAUKEE AVE SUITE 235, DEERFIELD, IL 60015 SN 1022-0178 J9 CRS BUI NAT PY 1996 BP 821 EP 822 PG 2 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA BH42C UT WOS:A1996BH42C00414 ER PT B AU Pham, T Sadler, BM AF Pham, T Sadler, BM GP IEEE TI Adaptive wideband aeroacoustic array processing SO 8TH IEEE SIGNAL PROCESSING WORKSHOP ON STATISTICAL SIGNAL AND ARRAY PROCESSING, PROCEEDINGS LA English DT Proceedings Paper CT 8th IEEE Signal Processing Workshop on Statistical Signal and Array Processing (SSAP) CY JUN 24-26, 1996 CL CORFU, GREECE SP IEEE, Signal Proc Soc, USA, Res Off, USN, Off Naval Res C1 USA,RES LAB,ADELPHI,MD 20783. NR 0 TC 16 Z9 18 U1 0 U2 2 PU I E E E, COMPUTER SOC PRESS PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, LOS ALAMITOS, CA 90720 BN 0-8186-7576-4 PY 1996 BP 295 EP 298 DI 10.1109/SSAP.1996.534875 PG 4 WC Computer Science, Information Systems; Engineering, Electrical & Electronic; Telecommunications SC Computer Science; Engineering; Telecommunications GA BF94C UT WOS:A1996BF94C00070 ER PT B AU Swami, A Sadler, B AF Swami, A Sadler, B GP IEEE TI Channel and intensity estimation for a class of point processes SO 8TH IEEE SIGNAL PROCESSING WORKSHOP ON STATISTICAL SIGNAL AND ARRAY PROCESSING, PROCEEDINGS LA English DT Proceedings Paper CT 8th IEEE Signal Processing Workshop on Statistical Signal and Array Processing (SSAP) CY JUN 24-26, 1996 CL CORFU, GREECE SP IEEE, Signal Proc Soc, USA, Res Off, USN, Off Naval Res C1 ARMY RES LAB,AMSRL,IS,TA,ADELPHI,MD 20783. NR 0 TC 1 Z9 1 U1 0 U2 1 PU I E E E, COMPUTER SOC PRESS PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, LOS ALAMITOS, CA 90720 BN 0-8186-7576-4 PY 1996 BP 440 EP 443 DI 10.1109/SSAP.1996.534910 PG 4 WC Computer Science, Information Systems; Engineering, Electrical & Electronic; Telecommunications SC Computer Science; Engineering; Telecommunications GA BF94C UT WOS:A1996BF94C00105 ER PT B AU David, P AF David, P BE Masten, MK Stockum, LA TI Real-time target acquisition for the Army's scout mission SO ACQUISITION, TRACKING, AND POINTING X SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Acquisition, Tracking, and Pointing X Conference CY APR 10-11, 1996 CL ORLANDO, FL SP Soc Photo Opt Instrumentat Engineers DE robotic-vehicle; target detection; target tracking C1 USA,RES LAB,ADELPHI,MD 20783. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPIE - INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 BN 0-8194-2120-0 J9 P SOC PHOTO-OPT INS PY 1996 VL 2739 BP 324 EP 331 DI 10.1117/12.241927 PG 8 WC Engineering, Aerospace; Remote Sensing; Optics SC Engineering; Remote Sensing; Optics GA BF87E UT WOS:A1996BF87E00030 ER PT B AU Bornstein, J Hillis, D AF Bornstein, J Hillis, D BE Masten, MK Stockum, LA TI Miss distance indicator for tank main guns SO ACQUISITION, TRACKING, AND POINTING X SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Acquisition, Tracking, and Pointing X Conference CY APR 10-11, 1996 CL ORLANDO, FL SP Soc Photo Opt Instrumentat Engineers DE multiple frame target tracking; tank gun accuracy C1 USA,RES LAB,ADELPHI,MD. NR 0 TC 0 Z9 0 U1 1 U2 1 PU SPIE - INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 BN 0-8194-2120-0 J9 P SOC PHOTO-OPT INS PY 1996 VL 2739 BP 332 EP 340 DI 10.1117/12.241929 PG 9 WC Engineering, Aerospace; Remote Sensing; Optics SC Engineering; Remote Sensing; Optics GA BF87E UT WOS:A1996BF87E00031 ER PT J AU Batra, RC Adulla, C Wright, TW AF Batra, RC Adulla, C Wright, TW TI Effect of defect shape and sie on the initiation of adiabatic shear bands SO ACTA MECHANICA LA English DT Article AB Backman and Finnegan [1] have pointed out that shear bands initiate from a defect such as a second phase particle, microcrack, or a void. The defect has been modeled as a sinusoidal variation in the thickness of the tubular specimens tested in torsion by Chi [2] and Murphy [3]. Here we simulate their torsional tests numerically and consider different shapes and sizes of defects. C1 USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005. RP Batra, RC (reprint author), VIRGINIA POLYTECH INST & STATE UNIV,DEPT ENGN SCI & MECH,BLACKSBURG,VA 24061, USA. NR 9 TC 7 Z9 7 U1 0 U2 3 PU SPRINGER-VERLAG WIEN PI VIENNA PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 VIENNA, AUSTRIA SN 0001-5970 J9 ACTA MECH JI Acta Mech. PY 1996 VL 116 IS 1-4 BP 239 EP 243 DI 10.1007/BF01171435 PG 5 WC Mechanics SC Mechanics GA UV155 UT WOS:A1996UV15500020 ER PT J AU Valanis, KC Peters, JF AF Valanis, KC Peters, JF TI Ill-posedness of the initial and boundary value problems in non-associative plasticity SO ACTA MECHANICA LA English DT Article ID INSTABILITY; DEFORMATION AB Associative plasticity theories do not predict correctly the volumetric plastic strain, in the course of plastic deformation, in the case of materials where the position and conformation of the yield surface are functions of the prevailing hydrostatic stress. Non-associative theories have been proposed and used to correct this deficiency. Such theories, however, lead to other serious difficulties. In this paper we establish clear criteria for the well-posedness of the initial, boundary/initial and boundary value problems when the plasticity theory is associative as well as non-associative. We further show cases where non-associativity leads to iu-posedness of these problems even when the material is not at failure. Specifically we demonstrate that the initial/boundary and boundary value problems either have no solution, or if they do, the solution is not unique. We also show by specific examples that the banding condition, i.e., the vanishing of the determinant of the acoustic tensor, is tantamount (a) to loss of hyperbolicity of the equation of motion and (b) lack of existence or loss of uniqueness of the solution of the boundary value problem, in certain situations. Finally, we show the existence of a fundamental criterion that governs the stability of infinitesimal as well as finite elastoplastic domains. C1 USA,WATERWAYS EXPT STN,VICKSBURG,MS 39190. RP Valanis, KC (reprint author), ENDOCHRON INC,8605 LAKECREST CT,VANCOUVER,WA 98665, USA. NR 29 TC 19 Z9 19 U1 0 U2 3 PU SPRINGER-VERLAG WIEN PI VIENNA PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 VIENNA, AUSTRIA SN 0001-5970 J9 ACTA MECH JI Acta Mech. PY 1996 VL 114 IS 1-4 BP 1 EP 25 DI 10.1007/BF01170392 PG 25 WC Mechanics SC Mechanics GA TR800 UT WOS:A1996TR80000001 ER PT B AU Stakhiv, EZ AF Stakhiv, EZ BE Smith, JB Bhatti, N Menzhulin, GV Benioff, R Campos, M Jallow, B Rijsberman, F Budyko, M Dixon, RK TI Managing water resources for climate change adaptation SO ADAPTING TO CLIMATE CHANGE: AN INTERNATIONAL PERSPECTIVE LA English DT Proceedings Paper CT International Conference on Climate Change Adaptation CY MAY 22-25, 1995 CL ST PETERSBURG, RUSSIA SP Russian Fed Serv Hydrometeorol & Environm Monitoring, US Country Studies Program, Netherlands Minist Foreign Affairs, Directorate Gen Int Cooperat RP Stakhiv, EZ (reprint author), USA,CORPS ENGINEERS,INST WATER RESOURCES,ALEXANDRIA,VA 22315, USA. NR 0 TC 10 Z9 10 U1 1 U2 1 PU SPRINGER-VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 BN 0-387-94639-X PY 1996 BP 243 EP 264 PG 22 WC Agronomy; Ecology; Environmental Sciences; Water Resources SC Agriculture; Environmental Sciences & Ecology; Water Resources GA BF01A UT WOS:A1996BF01A00021 ER PT B AU Johnson, JL AF Johnson, JL BE Caulfield, HJ Chen, SS TI The pulse coupled neural network as a computer SO ADAPTIVE COMPUTING: MATHEMATICAL AND PHYSICAL METHODS FOR COMPLEX ENVIRONMENTS SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Adaptive Computing - Mathematical and Physical Methods for Complex Environments CY AUG 04-05, 1996 CL DENVER, CO SP Soc Photo Opt Instrumentat Engineers AB The biological neuronal model is an electrically polarized membrane capacitor with numerous ionic channels for synaptic inputs and leakage currents. It is generally a complex system whose geometrical, electronic, and chemical substructures synergestically determine its temporal dynamics in response to its input distributions. The integrate-and-fire pulse generator resets a local internal voltage activity, which in turn interacts with the other voltage distributions in the dendrites. A recent closed-form solution to a compartmental neuronal model shows that it is a fully chaotic system with algorithmic properties that provide a new approach to object-oriented data processing. RP Johnson, JL (reprint author), USA,MISSILE COMMAND,CTR RES DEV & ENGN,AMSMI,RD,WS,PO,REDSTONE ARSENAL,AL 35898, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU SPIE - INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 BN 0-8194-2212-6 J9 P SOC PHOTO-OPT INS PY 1996 VL 2824 BP 66 EP 69 DI 10.1117/12.258118 PG 4 WC Computer Science, Artificial Intelligence; Optics SC Computer Science; Optics GA BG73J UT WOS:A1996BG73J00008 ER PT B AU Lattin, FG Paul, DG AF Lattin, FG Paul, DG BE VoDinh, T TI A method for near real time continuous air monitoring of phosgene, hydrogen cyanide, and cyanogen chloride SO ADVANCED TECHNOLOGIES FOR ENVIRONMENTAL MONITORING AND REMEDIATION SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Advanced Technologies for Environmental Monitoring and Remediation CY AUG 06-08, 1996 CL DENVER, CO SP Soc Photo Opt Instrumentat Engineers AB A sorbent-based gas chromatographic method provides continuous quantitative measurement of phosgene, hydrogen cyanide, and cyanogen chloride in ambient air. These compounds are subject to workplace exposure limits as well as regulation under terms of the Chemical Arms Treaty and Title III of the 1990 Clean Air Act amendments. The method was developed for on-site use in a mobile laboratory during remediation operations. Incorporated into the method are automated multi-level calibrations at time weighted average (TW) concentrations, or lower. Gaseous standards are prepared in fused silica lined air sampling canisters, then transferred to the analytical system through dynamic spiking. Precision and accuracy studies performed to validate the method are described. Also described are system deactivation and passivation techniques critical to optimum method performance. RP Lattin, FG (reprint author), USA,EDGEWOOD RES,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPIE - INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 BN 0-8194-2223-1 J9 P SOC PHOTO-OPT INS PY 1996 VL 2835 BP 180 EP 188 DI 10.1117/12.259771 PG 9 WC Engineering, Environmental; Remote Sensing; Optics SC Engineering; Remote Sensing; Optics GA BH01G UT WOS:A1996BH01G00021 ER PT S AU Dowling, JP GeaBanacloche, J AF Dowling, JP GeaBanacloche, J BE Bederson, B Walther, H TI Evanescent light-wave atom mirrors, resonators waveguides, and traps SO ADVANCES IN ATOMIC, MOLECULAR, AND OPTICAL PHYSICS, VOL 37 SE Advances In Atomic Molecular and Optical Physics LA English DT Review ID STABLE GRAVITATIONAL CAVITY; VELOCITY-TUNED RESONANCES; MAGNETOOPTICAL BEAM SPLITTER; HOLLOW OPTICAL FIBERS; LASER-LIGHT; DEBROGLIE WAVES; ELECTROMAGNETIC MIRROR; QUANTUM COMPUTATION; RADIATION PRESSURE; MULTILEVEL ATOMS C1 UNIV ARKANSAS, DEPT PHYS, FAYETTEVILLE, AR 72701 USA. RP Dowling, JP (reprint author), USA, MISSILE COMMAND, CTR RES DEV & ENGN, WEAPONS SCI DIRECTORATE, REDSTONE ARSENAL, AL 35898 USA. RI DOWLING, JONATHAN/L-2749-2013 NR 134 TC 123 Z9 124 U1 3 U2 12 PU ELSEVIER ACADEMIC PRESS INC PI SAN DIEGO PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA SN 1049-250X BN 0-12-003837-4 J9 ADV ATOM MOL OPT PHY JI Adv. Atom. Mol. Opt. Phys. PY 1996 VL 37 BP 1 EP 94 PG 94 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA BH82Z UT WOS:A1996BH82Z00001 ER PT B AU Melby, JA Turk, GF AF Melby, JA Turk, GF BE Clifford, JE TI CORE-LOC(TM) development as related to historical corps concrete armor unit performance SO ADVANCES IN COASTAL STRUCTURES AND BREAKWATERS LA English DT Proceedings Paper CT International Conference on Advances in Coastal Structures and Breakwaters CY APR 27-29, 1995 CL LONDON, ENGLAND SP Inst Civil Engineers C1 USA,ENGINEER WATERWAYS EXPT STN,COASTAL ENGN RES CTR,VICKSBURG,MS 39180. NR 0 TC 1 Z9 1 U1 2 U2 2 PU THOMAS TELFORD SERVICES LTD PI LONDON PA THOMAS TELFORD HOUSE, 1 HERON QUAY, LONDON, ENGLAND E14 4JD BN 0-7277-2509-2 PY 1996 BP 253 EP 272 PG 20 WC Engineering, Marine; Engineering, Civil SC Engineering GA BG05C UT WOS:A1996BG05C00016 ER PT B AU Hirvonen, JK Demaree, JD AF Hirvonen, JK Demaree, JD BE Clayton, CR Hirvonen, JK Srivatsa, AR TI DoD activities in ion beam processing SO ADVANCES IN COATINGS TECHNOLOGIES FOR SURFACE ENGINEERING LA English DT Proceedings Paper CT Symposium on Advances in Coatings Technologies for Surface Engineering, at the Annual Meeting of the Minerals-Metals-and-Materials-Society CY FEB 09-13, 1997 CL ORLANDO, FL SP Minerals Met & Mat Soc. Surface Modificat & Coatiangs Technol Comm AB Selected usages of environmentally benign ion beam processes, namely ion implantation and ion beam assisted deposition (IBAD), are discussed in terms of their technical merits, their current status, and the various factors governing their acceptance within the U.S. Department of Defense (DoD) user community. C1 USA, Res Lab, Met Res Branch, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Hirvonen, JK (reprint author), USA, Res Lab, Met Res Branch, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. NR 0 TC 2 Z9 2 U1 0 U2 1 PU MINERALS, METALS & MATERIALS SOC PI WARRENDALE PA 184 THORN HILL RD, WARRENDALE, PA 15086-7514 USA BN 0-87339-371-6 PY 1996 BP 53 EP 70 PG 18 WC Metallurgy & Metallurgical Engineering; Materials Science, Coatings & Films SC Metallurgy & Metallurgical Engineering; Materials Science GA BK37G UT WOS:000071923800003 ER PT S AU Ferguson, A Sabisch, T Kaye, P Dixon, LC Bolouri, H AF Ferguson, A Sabisch, T Kaye, P Dixon, LC Bolouri, H BE Touretzky, DS Mozer, MC Hasselmo, ME TI High-speed airborne particle monitoring using artificial neural networks SO ADVANCES IN NEURAL INFORMATION PROCESSING SYSTEMS 8: PROCEEDINGS OF THE 1995 CONFERENCE SE ADVANCES IN NEURAL INFORMATION PROCESSING SYSTEMS LA English DT Proceedings Paper CT 9th Annual Conference on Neural Information Processing Systems (NIPS) CY NOV 27-30, 1995 CL DENVER, CO C1 UNIV HERTFORDSHIRE,ERDC,HATFIELD AL10 9AB,HERTS,ENGLAND. NR 0 TC 1 Z9 1 U1 0 U2 0 PU M I T PRESS PI CAMBRIDGE PA 55 HAYWARD ST, CAMBRIDGE, MA 02142 SN 1049-5258 BN 0-262-20107-0 J9 ADV NEUR IN PY 1996 VL 8 BP 980 EP 986 PG 3 WC Computer Science, Information Systems; Neurosciences SC Computer Science; Neurosciences & Neurology GA BG45M UT WOS:A1996BG45M00138 ER PT J AU Ashforth, BE Mael, FA AF Ashforth, BE Mael, FA TI Organizational identity and strategy as a context for the individual SO ADVANCES IN STRATEGIC MANAGEMENT LA English DT Article ID PUNCTUATED EQUILIBRIUM; MEMBER IDENTIFICATION; INTERGROUP RELATIONS; SOCIAL IDENTITY; SELF; COMMUNICATION; CULTURE; IMAGE; WORK; CATEGORIZATION AB Organizational identity and strategy provide a context within which individuals are embedded, that is, simultaneously enabled and constrained. Identity refers to an organization's central, distinctive, and enduring character, typically anchored to its mission, whereas strategy refers to an organization's goals and the activities intended to achieve them. Identity can serve as a wellspring for strategy, although identity and strategy are reciprocally related such that identity is enacted and expressed via strategy, and inferred, modified, or affirmed from strategy. Identity and strategy are claims that are articulated and negotiated by organizational stakeholders and members. An identity that accords with or evokes a member's needs is more likely to be internalized as a valid statement of self. The resulting identification induces a member to depersonalize both self and others, and enact the organizational identity and attendant strategies, thereby shaping cognition (by priming attention and interpretation and perhaps fostering an outward focus), affect (by fusing self- and organizational-interests, influencing what is valued, and fostering self- and collective-efficacy), and behavior (by encouraging identity-consistent and cooperative actions). As potent forms of control, identity and strategy often prompt inertia. Although identities are inherently self-fulfilling, they are not deterministic. We close by cautioning against over-identification with any single organization. C1 USA,RES INST,ALEXANDRIA,VA. RP Ashforth, BE (reprint author), ARIZONA STATE UNIV,COLL BUSINESS,DEPT MANAGEMENT,TEMPE,AZ 85287, USA. NR 127 TC 124 Z9 126 U1 2 U2 39 PU JAI PRESS INC PI GREENWICH PA 55 OLD POST RD-#2, PO BOX 1678, GREENWICH, CT 06836-1678 SN 0742-3322 J9 ADV STRATEG MANAGE JI Adv. Strateg. Manag. PY 1996 VL 13 BP 19 EP 64 PG 46 WC Management SC Business & Economics GA WY335 UT WOS:A1996WY33500002 ER PT S AU Cross, AS Sadoff, JC Gemski, P Opal, SM AF Cross, AS Sadoff, JC Gemski, P Opal, SM BE MacVittie, TJ Weiss, JF Browne, D TI Selection of bacteria for animal models of sepsis SO ADVANCES IN THE TREATMENT OF RADIATION INJURIES SE ADVANCES IN THE BIOSCIENCES LA English DT Proceedings Paper CT 2nd Consensus Development Conference on the Treatment of Radiation Injuries CY APR 14-17, 1993 CL BETHESDA, MD SP Armed Forces Radiobiol Res Inst C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON PRESS LTD PI OXFORD PA THE BOULEVARD LANGFORD LANE KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0065-3446 BN 0-08-042497-X J9 ADV BIOSCI PY 1996 VL 94 BP 119 EP 126 PG 8 WC Medicine, Research & Experimental; Radiology, Nuclear Medicine & Medical Imaging SC Research & Experimental Medicine; Radiology, Nuclear Medicine & Medical Imaging GA BG19C UT WOS:A1996BG19C00014 ER PT J AU Messimer, SL Henshaw, JM Montgomery, J Rogers, J AF Messimer, SL Henshaw, JM Montgomery, J Rogers, J TI Composite design and manufacturing critiquing system SO AI EDAM-ARTIFICIAL INTELLIGENCE FOR ENGINEERING DESIGN ANALYSIS AND MANUFACTURING LA English DT Article DE critiquing systems; composites manufacturing AB An ongoing research effort is consolidating material and process knowledge in a critiquing system dealing with fuzzy criteria to aid designers in evaluating the incorporation of composite materials into their design. The extent of knowledge required to perform the task of evaluating composite processes and materials is often beyond the expertise of many design engineers as they lack understanding of the nature of composite material manufacturing. The system under development is known as the Composites Design and Manufacturing Critiquing System (CDMCS). The CDMCS critiques a submitted design through interaction with the user. An account of the strengths and weaknesses of the design is supplied to the user through the facilities. The current focus of the system is on process selection, but the system is generic so that other aspects of composite material manufacturing may be included. The system is implemented in Macintosh(TM) Common LISP. This article describes the features of the system that have been implemented. The system is currently being extended to cover more than the primary process component of the domain. C1 UNIV ALABAMA,DEPT IND & SYST ENGN,HUNTSVILLE,AL 35899. UNIV TULSA,DEPT MECH ENGN,TULSA,OK 74104. USA,MISSILE COMMAND,DIV PROD ENGN,REDSTONE ARSENAL,AL 35898. UNIV ALABAMA,CTR AUTOMAT & ROBOT,HUNTSVILLE,AL 35899. NR 13 TC 2 Z9 2 U1 0 U2 1 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 40 WEST 20TH STREET, NEW YORK, NY 10011-4211 SN 0890-0604 J9 AI EDAM JI AI EDAM-Artif. Intell. Eng. Des. Anal. Manuf. PD JAN PY 1996 VL 10 IS 1 BP 65 EP 79 PG 15 WC Computer Science, Artificial Intelligence; Computer Science, Interdisciplinary Applications; Engineering, Multidisciplinary; Engineering, Manufacturing SC Computer Science; Engineering GA TW679 UT WOS:A1996TW67900005 ER PT J AU Chandrasekhara, MS Wilder, MC Carr, LW AF Chandrasekhara, MS Wilder, MC Carr, LW TI Boundary-layer-tripping studies of compressible dynamic stall flow SO AIAA JOURNAL LA English DT Article ID AIRFOIL AB The challenging task of properly tripping the boundary layer of a leading-edge-stalling airfoil experiencing compressible dynamic stall at Reynolds numbers between 3.6 x 10(5) and 8.1 x 10(5) has been addressed. Real-time interferometry data of the flow over an oscillating airfoil have been obtained at freestream Mach numbers of 0.3 and 0.45. The airfoil was tripped by separately placing five different trips of varying lengths near the leading edge. The trip heights ranged from 40 to 175 mu m. The resulting flow and airfoil performance were evaluated using the criteria of elimination of the laminar separation bubble that otherwise forms, delay of dynamic stall onset to higher angles of attack, and production of consistently higher suction peaks. Quantitative analysis of the interferograms showed that the laminar separation bubble was still present with the smallest trip and premature dynamic stall occurred with the largest trip. The right trip was determined to be a distributed roughness element extending from 0.5 to 3% chord. Its height was found to compare reasonably with the airfoil boundary-layer thickness at the dynamic stall vortex formation angle of attack, at a location slightly upstream of the vortex origin in the adverse pressure gradient region. C1 USN,POSTGRAD SCH,MONTEREY,CA 93943. MCAT INST,SAN JOSE,CA 95127. USA,AEROFLIGHTDYNAM DIRECTORATE,MOFFETT FIELD,CA 94035. NR 22 TC 5 Z9 5 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0001-1452 J9 AIAA J JI AIAA J. PD JAN PY 1996 VL 34 IS 1 BP 96 EP 103 DI 10.2514/3.13027 PG 8 WC Engineering, Aerospace SC Engineering GA TP059 UT WOS:A1996TP05900014 ER PT B AU Sabio, V AF Sabio, V BE Zelnio, EG Douglass, RJ TI Spectral correlation of wideband target resonances SO ALGORITHMS FOR SYNTHETIC APERTURE RADAR IMAGERY III SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Algorithms for Synthetic Aperture Radar Imagery III Conference CY APR 10-12, 1996 CL ORLANDO, FL SP Soc Photo Opt Instrumentat Engineers DE ultra-wideband radar; SAR; foliage-penetration; automatic target recognition; resonance; spectral correlation C1 USA,RES LAB,ADELPHI,MD 20783. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPIE - INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 BN 0-8194-2138-3 J9 P SOC PHOTO-OPT INS PY 1996 VL 2757 BP 145 EP 151 DI 10.1117/12.242031 PG 7 WC Remote Sensing; Optics SC Remote Sensing; Optics GA BG01U UT WOS:A1996BG01U00014 ER PT B AU Rodkey, DL Welby, SP Hostetler, L AF Rodkey, DL Welby, SP Hostetler, L BE Zelnio, EG Douglass, RJ TI Clipping service: ATR-based SAR image compression SO ALGORITHMS FOR SYNTHETIC APERTURE RADAR IMAGERY III SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Algorithms for Synthetic Aperture Radar Imagery III Conference CY APR 10-12, 1996 CL ORLANDO, FL SP Soc Photo Opt Instrumentat Engineers DE SAR; image compression; target recognition; image interpretation; image understanding C1 USA,RES LAB,ADELPHI,MD. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPIE - INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 BN 0-8194-2138-3 J9 P SOC PHOTO-OPT INS PY 1996 VL 2757 BP 390 EP 396 DI 10.1117/12.242051 PG 7 WC Remote Sensing; Optics SC Remote Sensing; Optics GA BG01U UT WOS:A1996BG01U00036 ER PT J AU Musselman, LJ Bray, RD Knepper, DA AF Musselman, LJ Bray, RD Knepper, DA TI Isoetes x bruntonii (Isoetes engelmannii x I-hyemalis), a new hybrid quillwort from Virginia SO AMERICAN FERN JOURNAL LA English DT Article AB Isoetes xbruntonii is the hybrid between the diploid I. engelmannii (2n=22) and the tetraploid I. hyemalis (2n=44). An apparently sterile triploid (2n=33), it has megaspore features intermediate between the two parents, bur does not exhibit hybrid vigor. Isoetes xbruntonii is frequent at localities in the outer Coastal Plain of Virginia. C1 USA,CORPS ENGINEERS,NORFOLK,VA 23510. RP Musselman, LJ (reprint author), OLD DOMINION UNIV,DEPT BIOL SCI,NORFOLK,VA 23529, USA. NR 8 TC 6 Z9 8 U1 1 U2 1 PU AMER FERN SOC INC PI WASHINGTON PA C/O DAVID B LELLINGER, SMITHSONIAN INST, BOTANY DEPT, WASHINGTON, DC 20560 SN 0002-8444 J9 AM FERN J JI Am. Fern J. PD JAN-MAR PY 1996 VL 86 IS 1 BP 8 EP 15 DI 10.2307/1547603 PG 8 WC Plant Sciences SC Plant Sciences GA UH637 UT WOS:A1996UH63700002 ER PT J AU Shay, SS Conwell, DL Mehindru, V Hertz, B AF Shay, SS Conwell, DL Mehindru, V Hertz, B TI The effect of posture on gastroesophageal reflux event frequency and composition during fasting SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Article ID REPRODUCIBILITY; SPHINCTER AB Objective: To examine the influence of three postures (upright and left and right recumbent) on gastroesophageal reflux event (RE) frequency and composition and a possible mechanism for the observations. Method: A) Forty fasting patients with (E+, n = 20) and without (E-, n = 20) esophagitis were studied. Simultaneous manometry and pH monitoring were conducted in the left and right recumbent (10 min each) as well as the upright posture (20 min). RE were classified by the pH probe and/or the manometry catheter as acid or gas RE. B) In 23 patients referred for UGI series, radiographs were taken in the left and right recumbent and upright postures after barium and Fizzles. Results: A) Upright RE were similar in frequency in E+ and E- patients (2.6 +/- 0.5 Its 3.05 +/- 0.6). However, E+ patients had more recumbent RE (16.3 +/- 3 vs 0.65 +/- 0.2, p = 0.0001) than E- patients; moreover, the left recumbent posture had more recumbent RE than the right (10.9 +/- 2 vs 5.3 +/- 1, p < 0.02). Moving from recumbent to the upright posture had an opposite effect on RE in the two groups; RE decreased sixfold in E+ patients (16.3 +/- 3 vs 2.6 +/- 0.5, p = 0.0001) but increased fourfold in E- patients (0.65 +/- 0.2 vs 3.05 +/- 0.6, p = 0.0001). In examining RE composition in the E+ patients, RE were twofold more likely to be gas in the left recumbent posture (7.6 +/- 2 vs 3.3 +/- p < 0.1); in direct contrast, RE were eightfold more likely to be acid in the right recumbent posture (4.7 +/- 1 vs 0.6 +/- 0.5, p = 0.001). As expected from this observation, acid exposure was greater in the right than left posture (52 +/- 8 vs 15 + 6%, p < 0.0001). Although RE were too infrequent in E- patients to reach statistical significance, the effect of posture on the composition of the few RE that did occur mirrored that of the Ef patients. B) In 17/23 (74%) radiographs in the right recumbent posture, the EG junction was submerged in a barium pool below the air-barium interface in the stomach. In contrast, this occurred in 0/23 patients in the left recumbent and 1/23 patients in the upright postures because the EG junction was in the air above the barium pool. Conclusion: Posture has an influence on RE frequency and composition while fasting, and the latter is likely due to whether the EG junction is submerged below liquid gastric contents or in the air above the liquid gastric contents. C1 WALTER REED ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,WASHINGTON,DC 20307. CLEVELAND CLIN FDN,GASTROENTEROL SERV,CLEVELAND,OH 44195. CLEVELAND CLIN FDN,SERV RADIOL,CLEVELAND,OH 44195. NR 13 TC 30 Z9 31 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD JAN PY 1996 VL 91 IS 1 BP 54 EP 60 PG 7 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA TQ275 UT WOS:A1996TQ27500012 PM 8561144 ER PT J AU Wallace, MR Sharp, TW Smoak, B Iriye, C Rozmajzl, P Thornton, SA Batchelor, R Magill, AJ Lobel, HO Longer, CF Burans, JP AF Wallace, MR Sharp, TW Smoak, B Iriye, C Rozmajzl, P Thornton, SA Batchelor, R Magill, AJ Lobel, HO Longer, CF Burans, JP TI Malaria among United States troops in Somalia SO AMERICAN JOURNAL OF MEDICINE LA English DT Article ID FALCIPARUM-MALARIA; MEFLOQUINE; CHEMOPROPHYLAXIS; PROPHYLAXIS; DOXYCYCLINE AB PURPOSE: United States military personnel deployed to Somalia were at risk for malaria, including chloroquine-resistant Plasmodium falciparum malaria. This report details laboratory, clinical, preventive, and therapeutic aspects of malaria in this cohort. PATIENTS AND METHODS: The study took place in US military field hospitals in Somalia, with US troops deployed to Somalia between December 1992 and May 1993. Centralized clinical care and country-wide disease surveillance facilitated standardized laboratory diagnosis, clinical records, epidemiologic studies, and assessment of chemoprophylactic efficacy. RESULTS: Forty-eight cases of malaria occurred among US troops while in Somalia; 41 of these cases were P falciparum. Risk factors associated with malaria included: noncompliance with recommended chemoprophylaxis (odds ratio [OR] 2.4); failure to use bed nets (OR 2.6); and failure to keep sleeves rolled down (OR 2.2). Some patients developed malaria in spite of mefloquine (n = 8) or doxycycline (n = 5) levels compatible with chemoprophylactic compliance. Five mefloquine failures had both serum levels greater than or equal to 650 ng/mL and metabolite:mefloquine ratios over 2, indicating chemoprophylactic failure. All cases were successfully treated, including 1 patient who developed cerebral malaria. CONCLUSIONS: P falciparum malaria attack rates were substantial in the first several weeks of Operation Restore Hope. While most cases occurred because of noncompliance with personal protective measures or chemoprophylaxis, both mefloquine and doxycycline chemoprophylactic failures occurred. Military or civilian travelers to East Africa must be scrupulous in their attention to both chemoprophylaxis and personal protection measures. C1 USN,NAVAL MED CTR,DEPT INTERNAL MED,DIV INFECT DIS,SAN DIEGO,CA 92134. USN,MED RES INST,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. USN,MED CTR,OAKLAND,CA. USN,ENVIRONM & PREVENT MED UNIT 7,NAPLES,ITALY. USN,MED RES UNIT 3,CAIRO,EGYPT. CTR DIS CONTROL,ATLANTA,GA 30333. RP Wallace, MR (reprint author), USN,MED CTR,DEPT CLIN INVEST,SAN DIEGO,CA 92134, USA. NR 25 TC 82 Z9 82 U1 0 U2 7 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0002-9343 J9 AM J MED JI Am. J. Med. PD JAN PY 1996 VL 100 IS 1 BP 49 EP 55 DI 10.1016/S0002-9343(96)90011-X PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA TT033 UT WOS:A1996TT03300011 PM 8579087 ER PT J AU Johnson, JWC Yancey, MK AF Johnson, JWC Yancey, MK TI A critique of the new recommendations for weight gain in pregnancy SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article DE gestational weight gain; maternal weight gain; weight gain in pregnancy; guidelines for pregnancy weight gain ID INFANT BIRTH-WEIGHT; MATERNAL WEIGHT AB Recent Institute of Medicine recommendations for weight gain in pregnancy advocate a marked increase over prior guidelines, and for reasons that must be questioned. The objectives of these new guidelines are to reduce perinatal mortality, prematurity, and fetal growth retardation. Evidence of a causal relationship between less maternal weight gain and these adverse outcomes is lacking. In addition, the consequences of increased pregnancy weight gain have been incompletely assessed. The risk-to-benefit ratio may be prohibitive. The new recommendations, which will be considered by many to be clinical guidelines, fall short of the formulation criteria recommended by the United States Preventive Services Task Force. C1 TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,HONOLULU,HI 96859. RP Johnson, JWC (reprint author), UNIV FLORIDA,COLL MED,DEPT OBSTET & GYNECOL,GAINESVILLE,FL 32610, USA. NR 25 TC 35 Z9 38 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 1996 VL 174 IS 1 BP 254 EP 258 DI 10.1016/S0002-9378(96)70403-9 PN 1 PG 5 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA TR334 UT WOS:A1996TR33400040 PM 8572016 ER PT J AU Braverman, SE Howard, RS Bryant, PR Belandres, PV AF Braverman, SE Howard, RS Bryant, PR Belandres, PV TI Potential drug interactions in a physical medicine and rehabilitation clinic SO AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION LA English DT Article DE drug interactions; physical medicine; outpatient clinic; computers ID EMERGENCY AB Potentially preventable adverse drug-drug interactions increase morbidity and financial costs to hospitals and third party payers. This study's purpose is to document the prevalence of potential drug-drug interactions (PDDI) in patients referred to a Physical Medicine and Rehabilitation (PM&R) clinic, to identify risk factors associated with PDDI, and to evaluate physicians' ability to correctly identify these PDDI. Current medication lists were obtained by questionnaire and confirmed by chart review for 121 consecutive new patients. The physician-identified PDDI were compared with computer-identified PDDI. Twenty-seven patients (22 %; 95 % confidence interval, 15-31 %) had PDDI. PDDI were associated with number of medications (P = 0.0011) and PM&R subspecialty clinic (P = 0.012). Twenty-nine of the 46 computer-identified interactions (63 %) were not identified by the physicians, and the physicians falsely identified 28 other drug combinations as PDDI. Potential drug-drug interactions occur at high rates in PM&R outpatient populations, and physicians are inadequately prepared to identify these PDDI. C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. RP Braverman, SE (reprint author), WALTER REED ARMY MED CTR,PHYS MED & REHABIL SERV,WASHINGTON,DC 20307, USA. NR 20 TC 9 Z9 9 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0894-9115 J9 AM J PHYS MED REHAB JI Am. J. Phys. Med. Rehabil. PD JAN-FEB PY 1996 VL 75 IS 1 BP 44 EP 49 DI 10.1097/00002060-199601000-00013 PG 6 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA TY971 UT WOS:A1996TY97100010 PM 8645439 ER PT J AU Fisher, RS Grillo, FG SaribanSohraby, S AF Fisher, RS Grillo, FG SaribanSohraby, S TI Brefeldin A inhibition of apical Na+ channels in epithelia SO AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY LA English DT Article DE A(6) cells; current fluctuation analysis; noise; electrical; Golgi; protein trafficking; aldosterone ID FROG-SKIN; SODIUM-TRANSPORT; TIGHT EPITHELIA; GOLGI-COMPLEX; CELLS; AMILORIDE; PROTEINS AB Brefeldin A (BFA) is used to probe trafficking of proteins through the central vacuolar system (CVS) in a variety of cells. Transepithelial Na+ transport by high-resistance epithelia, such as A(6) cultured cells, is inhibited by BFA. Apical Na+ channels, as well as basolateral pumps and K+ channels, are complex proteins that probably traverse the CVS for routing to the plasma membrane. BFA (5 mu g/ml) decreases transepithelial Na+ current near zero and increases resistance reversibly after 4 h. Longer exposures are toxic. When tissues were treated for 20 with 0.2 mu g/ml BFA, Na+ transport also was reversibly inhibited. Using noise analysis, we found that BFA drastically reduced apical Na+ channel density. The increase in single channel current was consistent with cell hyperpolarization. After apical permeabilization with nystatin, changes in transepithelial current reflect changes in basolateral membrane transport. Transport at this membrane was inhibited by ouabain and cycloheximide, but not by BFA. After BFA, aldosterone was ineffective, suggesting that an intact CVS is required for stimulation by this hormone. Thus BFA inhibition of Na+ transport is localized at the apical membrane. Implications for channel turnover as a mechanism for regulating the Na+ transport rate are discussed. C1 FREE UNIV BRUSSELS, LAB PHYSIOPATHOL, B-1070 BRUSSELS, BELGIUM. RP Fisher, RS (reprint author), WALTER REED ARMY INST RES, DEPT NEPHROL, WASHINGTON, DC 20307 USA. NR 30 TC 17 Z9 18 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0363-6143 J9 AM J PHYSIOL-CELL PH JI Am. J. Physiol.-Cell Physiol. PD JAN PY 1996 VL 270 IS 1 BP C138 EP C147 PG 10 WC Cell Biology; Physiology SC Cell Biology; Physiology GA TT104 UT WOS:A1996TT10400015 PM 8772439 ER PT J AU Arndt, WF Truax, AL Barnett, FM Simmons, GE Brown, DC AF Arndt, WF Truax, AL Barnett, FM Simmons, GE Brown, DC TI MR diagnosis of bone contusions of the knee: Comparison of coronal T2-weighted fast spin-echo with fat saturation and fast spin-echo STIR images with conventional STIR images SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article AB OBJECTIVES. Bone contusions consist of posttraumatic marrow change resulting from a combination of hemorrhage, edema, and microtrabecular injury and are depicted on MR images as geographic, nonlinear areas of abnormally increased T2 marrow signal intensity. Detection of bone contusions is important, not only in that they are frequently a sign of more serious associated injury, but in that isolated contusions may account for clinical symptoms and thereby obviate further workup. We evaluated two promising rapid imaging sequences, T2-weighted fast spin-echo with fat saturation and fast spin-echo short inversion time (TI) inversion recovery (STIR) and compared their efficacy to that of conventional STIR for the diagnosis of bone contusions in knees. SUBJECTS AND METHODS. Fifty-one consecutive military, retired military, and military-dependent patients were prospectively entered. Imaging consisted of three experimental sequences: coronal TS-weighted fast spin-echo with spectroscopic fat saturation, fast spin-echo STIR, and STIR, as well as conventional T1, proton density, and T2. Each examination was interpreted by three radiologists, for a total of 153 interpretations. Each interpretation consisted of the conventional sequences plus one of the three experimental sequences, blinded to the other two, specifically addressing menisci, ligaments, bones, and soft tissues, A positive test result was defined as a diagnosis of bone contusion on any one of the three independent interpretations of a given examination. Our gold standard was the consensus opinion of all three radiologists in a retrospective, unblinded evaluation of all imaging sequences. Sensitivity and specificity of fast spin-echo with fat saturation and fast spin-echo STIR were then calculated and compared with STIR. RESULTS. Sensitivity and specificity for bone contusion diagnosis in the three experimental sequences were as follows: fast spin-echo with fat saturation, 91% sensitivity and 86% specificity; fast spin-echo STIR, 96% sensitivity and 96% specificity; and conventional STIR, 83% sensitivity and 93% specificity. Our results showed no statistically significant difference between either of the fast spin-echo sequences and conventional STIR (p>.05). CONCLUSION. Because of their comparable accuracy and short imaging time characteristics, coronal fast spin-echo with fat saturation and fast spin-echo STIR sequences are superior to conventional STIR sequences for the diagnosis of bone contusions in knees. RP Arndt, WF (reprint author), BROOKE ARMY MED CTR,DEPT RADIOL,2450 STANLEY RD,FT SAM HOUSTON,TX 78234, USA. NR 7 TC 35 Z9 38 U1 0 U2 1 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD JAN PY 1996 VL 166 IS 1 BP 119 EP 124 PG 6 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA TL367 UT WOS:A1996TL36700027 PM 8571859 ER PT J AU Gaertner, E Zeren, EH Fleming, MV Colby, TV Travis, WD AF Gaertner, E Zeren, EH Fleming, MV Colby, TV Travis, WD TI Biphasic synovial sarcomas arising in the pleural cavity - A clinicopathologic study of five cases SO AMERICAN JOURNAL OF SURGICAL PATHOLOGY LA English DT Article DE synovial sarcoma; malignant mesothelioma; sarcoma; pleura ID DIFFUSE MALIGNANT MESOTHELIOMA; PULMONARY BLASTOMA; IMMUNOHISTOCHEMICAL ANALYSIS; PLEUROPULMONARY BLASTOMA; PEROXIDASE COMPLEX; TUMOR; DIFFERENTIATION; CHILDHOOD; DIAGNOSIS; AVIDIN AB Five cases of primary synovial sarcoma of the pleura are presented with a discussion of differentiation from other biphasic malignant neoplasms, most notably malignant mesothelioma. The cases have clinical, histologic, and immunohistochemical features consistent with synovial sarcoma of soft tissue. The average age at initial presentation of the reported patients was 25 years with an approximate range of 9 to 50 years. A large pleural-based intrathoracic mass was identified in each case. Histologic analysis showed a biphasic (mixed) pattern composed of epithelial and spindle cells. The epithelial cells showed cleft-like to tubulopapillary growth with focal intraluminal periodic acid Schiff's (PAS)-positive, diastase-resistant secretions identified in four of the five cases. The spindle cell component was composed predominantly of densely packed, elongated, fusiform cells. Immunohistochemical staining showed positivity with antibodies against cytokeratin, BER.EP4, epithelial membrane antigen, and vimentin in all cases. The patients seem to have an aggressive course, with four deaths reported within 3 years from initial surgery. These cases represent the first reported cases of primary synovial sarcoma of the pleura and lend further credence to the theory that synovial sarcomas are derived from immature mesenchymal elements, not from synovium. C1 ARMED FORCES INST PATHOL,DEPT PULM & MEDIASTINAL PATHOL,WASHINGTON,DC 20306. WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. CUKUROVA UNIV,SCH MED,DEPT PATHOL,BALCALI,ADANA,TURKEY. MAYO CLIN,DEPT PATHOL,SCOTTSDALE,AZ. NR 45 TC 85 Z9 87 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0147-5185 J9 AM J SURG PATHOL JI Am. J. Surg. Pathol. PD JAN PY 1996 VL 20 IS 1 BP 36 EP 45 DI 10.1097/00000478-199601000-00004 PG 10 WC Pathology; Surgery SC Pathology; Surgery GA TQ557 UT WOS:A1996TQ55700004 PM 8540607 ER PT J AU Looareesuwan, S Viravan, C Webster, HK Kyle, DE Canfield, CJ AF Looareesuwan, S Viravan, C Webster, HK Kyle, DE Canfield, CJ TI Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for treatment of acute uncomplicated malaria in Thailand SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID AIDS; 566C80 AB The therapy of Plasmodium falciparum malaria continues to be a problem in many parts of Southeast Asia because of multidrug resistance to nearly all existing antimalarial drugs. Atovaquone is a novel hydroxynaphthoquinone with broad spectrum anti-protozoal activity. We recently evaluated the antimalarial activity of atovaquone in a series of dose-ranging studies in 317 patients with malaria at the Bangkok Hospital for Tropical Diseases. Originally, the drug was administered alone. Using atovaquone alone resulted in satisfactory, initial clinical responses in all patients; the mean parasite and fever clearance times were 62 and 53 hr, respectively. However, irrespective of the duration of therapy, overall cure rates were approximately 67%. In vitro sensitivity studies on parasites taken from patients prior to treatment and at the time of recrudescence showed a marked decrease in susceptibility to atovaquone in the recrudescent parasites, To improve cure rates, atovaquone was administered in combination with other drugs with antimalarial activity. Proguanil and tetracycline were chosen due to laboratory evidence of potentiation; doxycycline was selected because it has a longer half-life than tetracycline. Although pyrimethamine did not show laboratory evidence of potentiation with atovaquone, it was chosen as an alternative inhibitor of dihydrofolic acid reductase with a longer half-life than proguanil. The clinical studies with these drug combinations confirmed the laboratory results with marked improvement in cure rates for proguanil, tetracycline, and doxycycline; pyrimethamine showed only minimal improvement. Proguanil was subsequently selected as the preferred drug partner because of its long record of safety and the ability to use the drug in pregnant women and children. Of the 104 patients with falciparum malaria treated with atovaquone plus proguanil for 3-7 days, 101 were cured and had virtually no adverse side effects. The combination of atovaquone and proguanil also was effective in eliminating erythrocytic forms of P. vivax, but parasitemia recurred in most patients. C1 ARMED FORCES RES INST MED SCI,USA MED COMPONENT,DEPT IMMUNOL & PARASITOL,BANGKOK 10400,THAILAND. WELLCOME RES LABS,DEPT INFECT DIS,BECKENHAM BR3 3BS,KENT,ENGLAND. PHARMACEUT SYST INC,TALENT,OR 97540. RP Looareesuwan, S (reprint author), MAHIDOL UNIV,FAC TROP MED,BANGKOK HOSP TROP DIS,DEPT CLIN TROP MED,420-6 RAJVITHI RD,BANGKOK 10400,THAILAND. NR 16 TC 250 Z9 252 U1 0 U2 7 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JAN PY 1996 VL 54 IS 1 BP 62 EP 66 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA TU827 UT WOS:A1996TU82700014 PM 8651372 ER PT J AU Vaughan, JA Turell, MJ AF Vaughan, JA Turell, MJ TI Dual host infections: Enhanced infectivity of eastern equine encephalitis virus to Aedes mosquitoes mediated by Brugia microfilariae SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID VALLEY FEVER VIRUS; ENCEPHALOMYELITIS VIRUS; INGESTING MICROFILARIAE; INCREASED DISSEMINATION; DIROFILARIA-IMMITIS; CHIKUNGUNYA VIRUS; CULEX-PIPIENS; BLOOD MEALS; ALBOPICTUS; TRANSMISSION AB When mosquitoes feed on a vertebrate host that is infected concurrently with virus and microfilariae (mf), both pathogens are ingested. If mf penetrate the mosquito mid,out, a small portion of the ingested virus may disseminate directly into the mosquito hemocoel. This phenomenon, termed microfilarial enhancement of arboviral transmission, has the potential to enhance the infectivity of arboviruses to mosquitoes. We investigated whether concurrent ingestion of Brugia mf and eastern equine encephalitis virus would enhance the infectivity and subsequent transmissibility of the virus by Aedes mosquitoes. Trials with Ae. triseriatus and B. pahangi mf indicated that microfilarial enhancement was dose dependent. Both a sufficient number of penetrating mf and a sufficient viremia were required for enhancement to occur. Furthermore, studies with B. malayi and three species of Aedes indicated that under comparable conditions of host viremia and microfilaremia, microfilarial enhancement occurred in some mosquito species (i.e., Ae. aegypti and Ae. taeniorhynchus) but not in others (Ae. triseriatus). We suggest that certain key parameters determine whether dual virus/mf host infections will enhance arboviral infectivity to mosquitoes. These include species differences in the capacity of mf to penetrate the mosquito midgut, the amount of virus passing into the hemocoel during mf penetration, and the innate susceptibility of mosquitoes to hemocoelomically introduced virus. RP Vaughan, JA (reprint author), USA,MED RES INST INFECT DIS,DIAGNOST SYST DIV,FREDERICK,MD 21072, USA. NR 20 TC 14 Z9 16 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JAN PY 1996 VL 54 IS 1 BP 105 EP 109 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA TU827 UT WOS:A1996TU82700022 PM 8651361 ER PT J AU Beckett, DC Green, BW Thomas, SA Miller, AC AF Beckett, DC Green, BW Thomas, SA Miller, AC TI Epizoic invertebrate communities on upper Mississippi River unionid bivalves SO AMERICAN MIDLAND NATURALIST LA English DT Article ID FRESH-WATER MUSSELS; DREISSENA-POLYMORPHA; ZEBRA MUSSEL AB Based on the Great Lakes experience with Dreissena polymorpha, it is clear that the native freshwater mussel (family Unionidae) fauna will be one of the riverine communities most severely impacted if high zebra mussel densities occur. Negative impacts on unionids will also affect the epizoic invertebrate communities that live on the shells of the unionids. In 1991 and 1992 (prezebra mussel infestation) we determined the composition and density of epizoic invertebrates on individual unionids from the upper Mississippi River. The 1991 samples were from a location with a strong current; the numerically dominant epizoic invertebrates at this location were three species of hydropsychid caddisflies and the chironomid larvae: Polypedilum convictum, P. scalaenum group, Rheotanytarsus sp., Microtendipes pedellus group and Thienemannimyia group. Strong correlations existed between effective surface area (ESA) (amount of shell surface area above the sediment-water interface) of the individual unionids and: (1) number of epizoic chironomid larvae (r = 0.81); (2) number of hydropsychid caddisflies (r = 0.73), and (3) total number of epizoic invertebrates (r = 0.78). Sampling in a slower current area in 1992 revealed an epizoic composition dissimilar from that observed in 1991. Glyptotendipes nr. lobiferus was the most abundant epizoic larval chironomid, and, although caddisfly larvae were common, they mostly belonged to families other than the Hydropsychidae. Again, strong correlations existed between ESA of the unionids and: (1) total number of epizoic invertebrates (r = 0.64) and (2) number of epizoic chironomid larvae (r = 0.57). A strong correlation also existed between the size of the unionids and the number of epizoic taxa present (1991: r = 0.78; 1992: r = 0.77). Fifty-three invertebrate taxa were collected from the unionids; mean epizoic densities were ca. 9600 and 6400 invertebrates/m(2) of ESA in 1991 and 1992, respectively. These results indicate that unionids are important substrates for epibenthic invertebrates, especially in rivers in which other large clean substrates are in short supply. C1 USA,ENGINEER WATERWAYS EXPT STN,ENVIRONM LAB,VICKSBURG,MS 39180. RP Beckett, DC (reprint author), UNIV SO MISSISSIPPI,DEPT BIOL SCI,BOX 5018,HATTIESBURG,MS 39406, USA. NR 33 TC 17 Z9 17 U1 2 U2 9 PU AMER MIDLAND NATURALIST PI NOTRE DAME PA UNIV NOTRE DAME, NOTRE DAME, IN 46556 SN 0003-0031 J9 AM MIDL NAT JI Am. Midl. Nat. PD JAN PY 1996 VL 135 IS 1 BP 102 EP 114 DI 10.2307/2426876 PG 13 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA TQ763 UT WOS:A1996TQ76300012 ER PT J AU Kamtekar, SD Pande, R Ayyagari, MS Marx, KA Kaplan, DL Kumar, J Tripathy, S AF Kamtekar, SD Pande, R Ayyagari, MS Marx, KA Kaplan, DL Kumar, J Tripathy, S TI Trace analysis of Zn(II), Be(II), and Bi(III) by enzyme catalyzed chemiluminescence SO ANALYTICAL CHEMISTRY LA English DT Article ID ZINC AB A novel technique for the trace analysis of metal ions Zn(II), Be(II), and Bi(III) in bulk solutions is discussed. This technique involves the generation of a chemiluminescence signal from alkaline phosphatase catalyzed hydrolysis of a phosphate derivative of 1,2-dioxetane, Zn(II) can be determined by two methods, reactivation of the alkaline phosphatase apoenzyme and inhibition of the native enzyme, Be(II) and Bi(III) can be determined quantitatively by inhibition of the native enzyme, Subppb to ppm level detection of Zn(II), Be(II), and BI(III) has been achieved, Initial studies with mixed metals are also reported, The technique described is rapid and sensitive and can be readily applied to the microassay of heavy metal ions. C1 UNIV MASSACHUSETTS,DEPT CHEM,CTR ADV MAT,LOWELL,MA 01854. UNIV MASSACHUSETTS,DEPT PHYS,LOWELL,MA 01854. USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760. NR 19 TC 16 Z9 20 U1 2 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD JAN 1 PY 1996 VL 68 IS 1 BP 216 EP 220 DI 10.1021/ac950681u PG 5 WC Chemistry, Analytical SC Chemistry GA TN244 UT WOS:A1996TN24400037 PM 21619238 ER PT J AU DeKay, E AF DeKay, E TI One step closer to an electronic journal SO ANGLE ORTHODONTIST LA English DT Letter RP DeKay, E (reprint author), USA,WASHINGTON,DC 20310, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ANGLE ORTHODONTISTS RES EDUC FOUNDATION INC PI APPLETON PA 100 W LAWRENCE ST, SUITE 406, APPLETON, WI 54911 SN 0003-3219 J9 ANGLE ORTHOD JI Angle Orthod. PY 1996 VL 66 IS 1 BP 5 EP 6 PG 2 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA TV562 UT WOS:A1996TV56200007 ER PT S AU Gow, AJ Meese, DA AF Gow, AJ Meese, DA BE Collins, D TI Nature of basal debris in the GISP2 and Byrd ice cores and its relevance to bed processes SO ANNALS OF GLACIOLOGY, VOL. 22, 1996: PROCEEDINGS OF THE INTERNATIONAL SYMPOSIUM ON GLACIAL EROSION AND SEDIMENTATION SE ANNALS OF GLACIOLOGY LA English DT Proceedings Paper CT International Symposium on Glacial Erosion and Sedimentation CY AUG 20-25, 1995 CL REYKJAVIK, ICELAND SP Int Glaciol Soc C1 USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. NR 0 TC 27 Z9 28 U1 0 U2 0 PU INT GLACIOLOGICAL SOC PI CAMBRIDGE PA LENSFIELD RD, CAMBRIDGE, ENGLAND CB2 1ER SN 0260-3055 J9 ANN GLACIOL PY 1996 VL 22 BP 134 EP 140 PG 7 WC Geology SC Geology GA BG09M UT WOS:A1996BG09M00019 ER PT S AU Hunter, LE Powell, RD Lawson, DE AF Hunter, LE Powell, RD Lawson, DE BE Collins, D TI Morainal-bank sediment budgets and their influence on the stability of tidewater termini of valley glaciers entering Glacier bay, Alaska, USA SO ANNALS OF GLACIOLOGY, VOL. 22, 1996: PROCEEDINGS OF THE INTERNATIONAL SYMPOSIUM ON GLACIAL EROSION AND SEDIMENTATION SE ANNALS OF GLACIOLOGY LA English DT Proceedings Paper CT International Symposium on Glacial Erosion and Sedimentation CY AUG 20-25, 1995 CL REYKJAVIK, ICELAND SP Int Glaciol Soc C1 USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. NR 0 TC 24 Z9 24 U1 0 U2 1 PU INT GLACIOLOGICAL SOC PI CAMBRIDGE PA LENSFIELD RD, CAMBRIDGE, ENGLAND CB2 1ER SN 0260-3055 J9 ANN GLACIOL PY 1996 VL 22 BP 211 EP 216 PG 6 WC Geology SC Geology GA BG09M UT WOS:A1996BG09M00031 ER PT J AU Mahmoud, RA AF Mahmoud, RA TI CPR-not-indicated and futility SO ANNALS OF INTERNAL MEDICINE LA English DT Letter RP Mahmoud, RA (reprint author), WALTER REED ARMY INST RES,WASHINGTON,DC 20307, USA. NR 1 TC 2 Z9 2 U1 0 U2 0 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD JAN 1 PY 1996 VL 124 IS 1 BP 76 EP 76 PN 1 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA TL943 UT WOS:A1996TL94300025 PM 7503490 ER PT J AU Shorr, AF AF Shorr, AF TI CPR-not-indicated and futility SO ANNALS OF INTERNAL MEDICINE LA English DT Letter RP Shorr, AF (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD JAN 1 PY 1996 VL 124 IS 1 BP 76 EP 76 PN 1 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA TL943 UT WOS:A1996TL94300024 PM 7503492 ER PT J AU Whelen, AC Persing, DH AF Whelen, AC Persing, DH TI The role of nucleic acid amplification and detection in the clinical microbiology laboratory SO ANNUAL REVIEW OF MICROBIOLOGY LA English DT Review DE polymerase chain reaction (PCR); molecular biology; pulsed-field gel electrophoresis; infectious diseases ID POLYMERASE CHAIN-REACTION; HUMAN-IMMUNODEFICIENCY-VIRUS; HEPATITIS-C VIRUS; CHLAMYDIA-TRACHOMATIS INFECTION; HUMAN HERPESVIRUS-6 INFECTION; URACIL-DNA GLYCOSYLASE; HERPES-SIMPLEX VIRUS; EPSTEIN-BARR-VIRUS; Q-BETA REPLICASE; RESISTANT MYCOBACTERIUM-TUBERCULOSIS AB Clinical microbiology is in the midst of a new era. Methodology that is based on nucleic acid detection has slowly appeared in the diagnostic laboratory, and is revolutionizing our ability to assist physicians in the diagnosis and management of patients suffering from infectious diseases. Much like the introduction of immunoassays built around hybridoma technology in the 1980s, considerable doubt and promise exist hand in hand in the 1990s. Conventional testing that is technically straight forward, informative, and timely will always be a part of clinical microbiology; however, considerable room for improvement exists with organisms/diseases for which laboratory methods are limited. Nucleic acid methodology will have its greatest and long-awaited impact in this arena. C1 MAYO CLIN & MAYO FDN,DIV CLIN MICROBIOL,ROCHESTER,MN 55905. MAYO CLIN & MAYO FDN,DIV EXPT PATHOL,ROCHESTER,MN 55905. RP Whelen, AC (reprint author), BROOKE ARMY MED CTR,MICROBIOL SERV,FT SAM HOUSTON,TX 78234, USA. RI Beletini, Lucimara Fatima/H-6083-2016 NR 210 TC 62 Z9 63 U1 0 U2 3 PU ANNUAL REVIEWS INC PI PALO ALTO PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 SN 0066-4227 J9 ANNU REV MICROBIOL JI Annu. Rev. Microbiol. PY 1996 VL 50 BP 349 EP 373 DI 10.1146/annurev.micro.50.1.349 PG 25 WC Microbiology SC Microbiology GA VL560 UT WOS:A1996VL56000012 PM 8905084 ER PT B AU Rajagopalan, G Gillespie, JW McKnight, SH AF Rajagopalan, G Gillespie, JW McKnight, SH GP SOC PLAST ENGINEERS INC TI Interdiffusion in a poly-aryl-ether-ether-ketone (peek) epoxy system SO ANTEC '96: PLASTICS - RACING INTO THE FUTURE, VOLS I-III: VOL I: PROCESSING; VOL II: MATERIALS; VOL III: SPACIAL AREAS SE SOCIETY OF PLASTICS ENGINEERS TECHNICAL PAPERS LA English DT Proceedings Paper CT 54th Annual Technical Conference of the Society-of-Plastics-Engineers - Plastics: Racing into the Future (ANTEC 96) CY MAY 05-10, 1996 CL INDIANAPOLIS, IN SP Soc Plast Engineers AB This study investigates the diffusion of a bisphenol A epoxy into as-received amorphous PEEK film and the associated morphological changes in PEEK due to this diffusion. The presence of diffusion at the epoxy/PEEK interface has been established through autoclave processing studies. Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (FTIR-ATR) studies have been used to characterize this diffusion mechanism and also in optimizing the dwell time-temperature window for autoclave processing. The diffusion process was studied at various time intervals by measuring the change in absorbance bands of selected characteristic peaks in each polymer. It was concluded that the diffusion of epoxy into PEEK is anomalous and a pseudo-diffusion coefficient was determined using the experimental data. Further, the presence of induced crystallinity in the PEEK film from epoxy diffusion was studied using wide-angle-xray scattering techniques and identified as an important consideration for autoclave process optimization. C1 UNIV DELAWARE,CTR COMPOSITE MAT,ARMY RES LABS,NEWARK,DE 19716. RP Rajagopalan, G (reprint author), UNIV DELAWARE,MAT SCI PROGRAM,NEWARK,DE 19716, USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU SOC PLASTICS ENGINEERS PI BROOKFIELD CENTER PA 14 FAIRFIELD DR, BROOKFIELD CENTER, CT 06805 J9 SOC PLAST E PY 1996 VL 42 BP 1225 EP 1230 PG 6 WC Engineering, Chemical; Engineering, Mechanical; Materials Science, Multidisciplinary; Polymer Science SC Engineering; Materials Science; Polymer Science GA BH28W UT WOS:A1996BH28W00204 ER PT S AU Gotoff, S Ben-David, A Vanderbeek, R AF Gotoff, S Ben-David, A Vanderbeek, R BE Sedlacek, AJ TI Spectral variation of a combined topographical surface albedo, and atmospheric transmission in a CO2 airborne lidar experiment SO APPLICATION OF LIDAR TO CURRENT ATMOSPHERIC TOPICS SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Application of Lidar to Current Atmospheric Topics CY AUG 08-09, 1996 CL DENVER, CO SP Soc Photo Opt Instrumentat Engineers, N Amer Remote Sensing Ind Assoc, Amer Soc Photogrammetry & Remote Sensing DE CO2 lidar; DIAL; surface reflectivity; albedo; correlation AB Combined spectral topographical surface albedo and atmospheric transmission for a rapidly tuned CO2 airborne lidar are presented for 19 wavelengths, separated by 5 ms. The measurements were gathered over a large topographical area and show high signal-to-noise ratio (greater than 5) with single pulse acquisition for ranges up to 8 km. The temporal cross-correlation for different wavelengths is also presented and shows a relatively high correlation between wavelengths for about 20-50 ms. The implication of the measurements to the DIAL method is discussed. RP Gotoff, S (reprint author), USA, EDGEWOOD RES DEV & ENGN CTR, CHEM & BIOL DEF COMMAND, ABERDEEN PROVING GROUND, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 0-8194-2221-5 J9 PROC SPIE PY 1996 VL 2833 BP 94 EP 104 DI 10.1117/12.258144 PG 11 WC Remote Sensing; Optics SC Remote Sensing; Optics GA BG81Y UT WOS:A1996BG81Y00011 ER PT B AU Meyers, RE Deacon, KS AF Meyers, RE Deacon, KS BE Sedlacek, AJ TI Atmospheric dynamics of signal propagation SO APPLICATION OF LIDAR TO CURRENT ATMOSPHERIC TOPICS SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Application of Lidar to Current Atmospheric Topics CY AUG 08-09, 1996 CL DENVER, CO SP Soc Photo Opt Instrumentat Engineers, N Amer Remote Sensing Ind Assoc, Amer Soc Photogrammetry & Remote Sensing AB This paper discusses the atmospheric dynamics of signal propagation associated with lidar operation through a realistic turbulent atmosphere in the vicinity of chemical plumes. Traditional phase screen models represent the propagation through artificial turbulence without dynamic compatibility. Ln contrast, three new models, AIRFLOS, CHAFFSIM, and SIMLIGHT have been developed to provide a first principles physics approach to modeling lidar signal propagation through a dynamically consistent atmosphere. Solving the Navier Stokes equations the AIRFLOS model computes the turbulence and index of refraction over complex terrain and structures as a function of space and time, CHAFFSIM computes the chemical concentration motion, and SIMLIGHT models the electromagnetic energy propagation. Together these models allow simulation of lidar propagation through realistic atmospheric en environments. RP Meyers, RE (reprint author), USA,RES LAB,ADELPHI,MD 20783, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPIE - INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 BN 0-8194-2221-5 J9 P SOC PHOTO-OPT INS PY 1996 VL 2833 BP 160 EP 172 DI 10.1117/12.258152 PG 3 WC Remote Sensing; Optics SC Remote Sensing; Optics GA BG81Y UT WOS:A1996BG81Y00018 ER PT B AU Zahirniak, DR DeSimio, MP AF Zahirniak, DR DeSimio, MP BE Rogers, SK Ruck, DW TI Time series prediction: Statistical and neural techniques SO APPLICATIONS AND SCIENCE OF ARTIFICIAL NEURAL NETWORKS II SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT SPIE International Conference on Applications and Science of Artificial Neural Networks II CY APR 09-12, 1996 CL ORLANDO, FL SP Soc Photo Opt Instrumentat Engineers DE time series analysis; optimal filtering; prediction; radial basis functions; multilayer perceptron C1 USA,INST TECHNOL,DEPT ELECT & COMP ENGN,WRIGHT PATTERSON AFB,OH 45433. NR 0 TC 0 Z9 0 U1 1 U2 1 PU SPIE - INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 BN 0-8194-2141-3 J9 P SOC PHOTO-OPT INS PY 1996 VL 2760 BP 202 EP 213 DI 10.1117/12.235911 PG 12 WC Computer Science, Artificial Intelligence; Optics; Physics, Applied SC Computer Science; Optics; Physics GA BF31U UT WOS:A1996BF31U00020 ER PT B AU Vrabel, MJ AF Vrabel, MJ BE Rogers, SK Ruck, DW TI Edge detection with a recurrent neural network SO APPLICATIONS AND SCIENCE OF ARTIFICIAL NEURAL NETWORKS II SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT SPIE International Conference on Applications and Science of Artificial Neural Networks II CY APR 09-12, 1996 CL ORLANDO, FL SP Soc Photo Opt Instrumentat Engineers DE optimization; recurrent neural network; Hopfield neural network; neural network; edge detection C1 USA,RES LAB,ADELPHI,MD 20783. NR 0 TC 1 Z9 2 U1 0 U2 0 PU SPIE - INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 BN 0-8194-2141-3 J9 P SOC PHOTO-OPT INS PY 1996 VL 2760 BP 365 EP 371 DI 10.1117/12.235958 PG 7 WC Computer Science, Artificial Intelligence; Optics; Physics, Applied SC Computer Science; Optics; Physics GA BF31U UT WOS:A1996BF31U00037 ER PT J AU McNesby, KL Daniel, RG Widder, JM Miziolek, AW AF McNesby, KL Daniel, RG Widder, JM Miziolek, AW TI Spectroscopic investigation of atmospheric-pressure counterflow diffusion flames inhibited by halons SO APPLIED SPECTROSCOPY LA English DT Article DE flame inhibition; halon replacement; FT-IR spectroscopy; diffusion flames AB Infrared spectra of atmospheric-pressure counterflow diffusion flames inhibited by halons (a contraction of halogenated hydrocarbons) and a few of their potential replacements are measured with the use of Fourier transform spectroscopy. Results are compared to spectra of similar flame systems examined at low pressure. It is shown that, for atmospheric pressure counterflow diffusion methane/air flames inhibited by CF3Br, CF2H2, and CF4, the two major fluorine-containing combustion products are HF and CF2O. A correlation is shown between flame inhibition efficiency and CF2O formation for atmospheric-pressure counterflow diffusion flames inhibited by these halons. For low-pressure premixed flames inhibited by CF3Br, HF appears to be the only fluorine-containing combustion product, even at relative dopant levels 15 times higher than those capable of extinguishing atmospheric-pressure counterflow diffusion flames. The results of these experiments illustrate the need for flame inhibitant testing over a wide spectrum of flame conditions, while providing further evidence that, for atmospheric-pressure inhibition of real fires by halons, CF2O may be a good indicator of inhibitor efficiency when that inhibition is at least partly accomplished by chemical scavenging of reactive combustion intermediates. RP McNesby, KL (reprint author), USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 18 TC 12 Z9 12 U1 1 U2 1 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA PO BOX 1438, FREDERICK, MD 21701 SN 0003-7028 J9 APPL SPECTROSC JI Appl. Spectrosc. PD JAN PY 1996 VL 50 IS 1 BP 126 EP 130 DI 10.1366/0003702963906762 PG 5 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA TQ781 UT WOS:A1996TQ78100019 ER PT J AU Simeonsson, JB Sausa, RC AF Simeonsson, JB Sausa, RC TI A critical review of laser photofragmentation fragment detection techniques for gas phase chemical analysis SO APPLIED SPECTROSCOPY REVIEWS LA English DT Review ID ENHANCED MULTIPHOTON IONIZATION; FLUORESCENCE SPECTROMETRIC DETERMINATION; GASEOUS NITRIC-ACID; MASS-SPECTROMETRY; MULTI-PHOTON; AIRBORNE MEASUREMENTS; EXCITATION MECHANISM; STIMULATED-EMISSION; STATE DISTRIBUTIONS; SELECTIVE DETECTION AB A comprehensive review of Laser Photofragmentation/Fragment Detection techniques for spectrochemical analysis is presented. The techniques involve one and/or multiple lasers for both photolysis of the analyte and detection of the characteristic daughter photofragments. Fragment detection is accomplished by laser-induced fluorescence, photoionization, prompt emission, stimulated emission, and/or laser ionization recombination emission techniques. Recent applications of these techniques for chemical analysis include the detection of analytes by their characteristic atomic and molecular fragments. Various techniques are compared and contrasted, and future applications in analytical chemistry are discussed. A key to the main acronyms and abbreviations used in the text is provided in a glossary at the end of this review. C1 USA,BALLIST RES LAB,PC,WT,AMSRL,ABERDEEN PROVING GROUND,MD 21005. RP Simeonsson, JB (reprint author), UNIV IOWA,DEPT CHEM,IOWA CITY,IA 52242, USA. NR 103 TC 48 Z9 49 U1 3 U2 12 PU MARCEL DEKKER INC PI NEW YORK PA 270 MADISON AVE, NEW YORK, NY 10016 SN 0570-4928 J9 APPL SPECTROSC REV JI Appl. Spectrosc. Rev. PY 1996 VL 31 IS 1-2 BP 1 EP 72 DI 10.1080/05704929608000564 PG 72 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA UV153 UT WOS:A1996UV15300002 ER PT J AU Johnson, ED Johnson, BK Silverstein, D Tukei, P Geisbert, TW Sanchez, AN Jahrling, PB AF Johnson, ED Johnson, BK Silverstein, D Tukei, P Geisbert, TW Sanchez, AN Jahrling, PB TI Characterization of a new Marburg virus isolated from a 1987 fatal case in Kenya SO ARCHIVES OF VIROLOGY LA English DT Article; Proceedings Paper CT International Symposium on Imported Virus Infections CY MAR 31-APR 01, 1995 CL UNIV MUNICH, MAX VON PETTENKOFER INST, MUNICH, GERMANY SP Abbaott Gmbh, Baxter Deut, Behringwerke AG, Biotest Pharma Gmbh, Boehringer Mannheim Gmbh, Deut Vereinigungzur Bekampf Viruskrankheiten e V, Deut Wellcome GmbH, Dr Karl Thomae Gmbh, Forderverein Deut Grunen Kreuzes, Immuno Gmbh, Inst Virion Gmbh, Pasteur Merieux MSD Gmbh, Procter & Gamble Gmbh, Sanofi Gmbh, SmithKline Beecham Gmbh HO UNIV MUNICH, MAX VON PETTENKOFER INST ID EBOLA VIRUS; DISEASE AB In 1987, an isolated case of fatal Marburg disease was recognized during routine clinical haemorrhagic fever virus surveillance conducted in Kenya. This report describes the isolation and partial characterization of the new Marburg virus (strain Ravn) isolated from this case. The Ravn isolate was indistinguishable from reference Marburg virus strains by cross-neutralization testing. Virus particles and aggregates of Marburg nucleocapsid matrix in Ravn-infected vero cells, were visualized by immunoelectron microscopic techniques, and also in tissues obtained from the patient and from inoculated monkeys. The cell culture isolate produced a haemorrhagic disease typical of Marburg virus infection when inoculated into rhesus monkeys. Disease was characterized by the sudden appearance of fever and anorexia within 4 to 7 days, and death by day 11. Comparison of nucleotide sequences for portions of the glycoprotein genes of Marburg-Ravn were compared with Marburg reference strains Musoki (MUS) and Popp (POP). Nucleotide identity in this alignment between RAV and MUS is 72.3%, RAV and POP is 71%, and MUS and POP is 91.7%. Amino acid identity between RAV and MUS is 72%, RAV and POP is 67%, and MUS and POP is 93%. These data suggest that Ravn is another subtype of Marburg virus, analogous to the emerging picture of a spectrum of Ebola geographic isolates and subtypes. C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. NAIROBI HOSP,NAIROBI,KENYA. KENYA GOVT MED RES CTR,VIRUS RES CTR,NAIROBI,KENYA. CTR DIS CONTROL,SPECIAL PATHOGENS BRANCH,ATLANTA,GA 30333. NR 21 TC 52 Z9 53 U1 0 U2 2 PU SPRINGER-VERLAG WIEN PI VIENNA PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 VIENNA, AUSTRIA SN 0304-8608 J9 ARCH VIROL JI Arch. Virol. PY 1996 SU 11 BP 101 EP 114 PG 14 WC Virology SC Virology GA VD911 UT WOS:A1996VD91100011 ER PT J AU Jahrling, PB Geisbert, TW Jaax, NK Hanes, MA Ksiazek, TG Peters, CJ AF Jahrling, PB Geisbert, TW Jaax, NK Hanes, MA Ksiazek, TG Peters, CJ TI Experimental infection of cynomolgus macaques with Ebola-Reston filoviruses from the 1989-1990 US epizootic SO ARCHIVES OF VIROLOGY LA English DT Article; Proceedings Paper CT International Symposium on Imported Virus Infections CY MAR 31-APR 01, 1995 CL UNIV MUNICH, MAX VON PETTENKOFER INST, MUNICH, GERMANY SP Abbaott Gmbh, Baxter Deut, Behringwerke AG, Biotest Pharma Gmbh, Boehringer Mannheim Gmbh, Deut Vereinigungzur Bekampf Viruskrankheiten e V, Deut Wellcome GmbH, Dr Karl Thomae Gmbh, Forderverein Deut Grunen Kreuzes, Immuno Gmbh, Inst Virion Gmbh, Pasteur Merieux MSD Gmbh, Procter & Gamble Gmbh, Sanofi Gmbh, SmithKline Beecham Gmbh HO UNIV MUNICH, MAX VON PETTENKOFER INST ID IMMUNOELECTRON MICROSCOPY; HEMORRHAGIC-FEVER; VIRUS-INFECTION; UNITED-STATES; MONKEYS; PRIMATES; ANTIGENS; MARBURG AB This study describes the pathogenesis of the Ebola-Reston (EBO-R) subtype of Ebola virus for experimentally infected cynomolgus monkeys. The disease course of EBO-R in macaques was very similar to human disease and to experimental diseases in macaques following EBO-Zaire and EBO-Sudan infections. Cynomolgus monkeys infected with EBO-R in this experiment developed anorexia, occasional nasal discharge, and splenomegaly, petechial facial hemorrhages and severe subcutaneous hemorrhages in venipuncture sites, similar to human Ebola fever. Five of the six EBO-R infected monkeys died, 8 to 14 days after inoculation. One survived and developed high titered neutralizing antibodies specific for EBO-R. The five acutely ill monkeys shed infectious virus in various bodily secretions. Further, abundant virus was visualized in alveolar interstitial cells and free in the alveoli suggesting the potential for generating infectious aerosols. Thus, taking precautions against aerosol exposures to filovirus infected primates, including humans, seems prudent. This experiment demonstrated that EBO-R was lethal for macaques and was capable of initiating and sustaining the monkey epizootic. Further investigation of this animal model should facilitate development of effective immunization, treatment, and control strategies for Ebola hemorrhagic fever. RP Jahrling, PB (reprint author), USA,MED RES INST INFECT DIS,HEADQUARTERS,FT DETRICK,FREDERICK,MD 20712, USA. NR 34 TC 11 Z9 11 U1 0 U2 5 PU SPRINGER-VERLAG WIEN PI VIENNA PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 VIENNA, AUSTRIA SN 0304-8608 J9 ARCH VIROL JI Arch. Virol. PY 1996 SU 11 BP 115 EP 134 PG 20 WC Virology SC Virology GA VD911 UT WOS:A1996VD91100012 ER PT J AU Jahrling, PB Geisbert, J Swearengen, JR Jaax, GP Lewis, T Huggins, JW Schmidt, JJ LeDuc, JW Peters, CJ AF Jahrling, PB Geisbert, J Swearengen, JR Jaax, GP Lewis, T Huggins, JW Schmidt, JJ LeDuc, JW Peters, CJ TI Passive immunization of Ebola virus-infected cynomolgus monkeys with immunoglobulin from hyperimmune horses SO ARCHIVES OF VIROLOGY LA English DT Article; Proceedings Paper CT International Symposium on Imported Virus Infections CY MAR 31-APR 01, 1995 CL UNIV MUNICH, MAX VON PETTENKOFER INST, MUNICH, GERMANY SP Abbaott Gmbh, Baxter Deut, Behringwerke AG, Biotest Pharma Gmbh, Boehringer Mannheim Gmbh, Deut Vereinigungzur Bekampf Viruskrankheiten e V, Deut Wellcome GmbH, Dr Karl Thomae Gmbh, Forderverein Deut Grunen Kreuzes, Immuno Gmbh, Inst Virion Gmbh, Pasteur Merieux MSD Gmbh, Procter & Gamble Gmbh, Sanofi Gmbh, SmithKline Beecham Gmbh HO UNIV MUNICH, MAX VON PETTENKOFER INST AB A commercially available immunoglobulin G (IgG) from horses, hyperimmunized to Ebola virus, was evaluated for its ability to protect cynomolgus monkeys against disease following i.m. inoculation with 1000 PFU Ebola virus (Zaire '95 strain). Six monkeys were treated immediately after infection by i.m. injection of 6.0 mi IgG; these animals developed passive ELISA titers of 1:160 to 1:320 to Ebola, two days after inoculation. However, the beneficial effects of IgG treatment were limited to a delay in onset of viremia and clinical signs, in comparison with untreated controls. The six Ige recipients had no detectable viremia day 5, in contrast with three virus infected controls whose viremias exceeded 7.0 log(10) PFU/ml that day. The controls died on days 6, 6, and 7, while two IgG recipients died day 7 and the remaining 4 died day 8, all with high viremias. These results document that passively acquired antibody can have a beneficial effect in reducing the viral burden in Ebola-infected primates; however, effective treatment of human patients may require antibodies with higher specific activities and more favorable pharmacokinetic properties than the presently available equine IgG. RP Jahrling, PB (reprint author), USA,MED RES INST INFECT DIS,HEADQUARTERS,FT DETRICK,FREDERICK,MD 21702, USA. NR 14 TC 25 Z9 28 U1 1 U2 5 PU SPRINGER-VERLAG WIEN PI VIENNA PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 VIENNA, AUSTRIA SN 0304-8608 J9 ARCH VIROL JI Arch. Virol. PY 1996 SU 11 BP 135 EP 140 PG 6 WC Virology SC Virology GA VD911 UT WOS:A1996VD91100013 ER PT J AU Peters, CJ Jahrling, PB Khan, AS AF Peters, CJ Jahrling, PB Khan, AS TI Patients infected with high-hazard viruses: Scientific basis for infection control SO ARCHIVES OF VIROLOGY LA English DT Article; Proceedings Paper CT International Symposium on Imported Virus Infections CY MAR 31-APR 01, 1995 CL UNIV MUNICH, MAX VON PETTENKOFER INST, MUNICH, GERMANY SP Abbaott Gmbh, Baxter Deut, Behringwerke AG, Biotest Pharma Gmbh, Boehringer Mannheim Gmbh, Deut Vereinigungzur Bekampf Viruskrankheiten e V, Deut Wellcome GmbH, Dr Karl Thomae Gmbh, Forderverein Deut Grunen Kreuzes, Immuno Gmbh, Inst Virion Gmbh, Pasteur Merieux MSD Gmbh, Procter & Gamble Gmbh, Sanofi Gmbh, SmithKline Beecham Gmbh HO UNIV MUNICH, MAX VON PETTENKOFER INST ID RIFT-VALLEY FEVER; ARGENTINE HEMORRHAGIC-FEVER; LASSA FEVER; RHESUS MACAQUES; STRINGENT PRECAUTIONS; NOSOCOMIAL OUTBREAK; EBOLA-VIRUS; MONKEYS; MARBURG; STRAIN AB Most of the viral hemorrhagic fevers (VHFs) are caused by viruses that are handled in high containment laboratories in Europe and the United States because of their high pathogenicity and their aerosol infectivity. Special precautions should be taken when caring for patients infected with these viruses, but most hospitals can safely provide high-quality care. The major danger is parenteral inoculation of a staff member. Fomites and droplets must be considered as well. The role of small particle aerosols in inter-human transmission continues to be controversial. We believe that the aerosol infectivity observed for these viruses in the laboratory and the rare clinical situations that suggest aerosol spread dictate caution, but the many instances in which no transmission occurs provide a framework in which a measured approach is possible. The major challenge is in early recognition by an educated medical staff and rapid specific etiologic diagnosis. C1 USA,MED RES INST INFECT DIS,FREDERICK,MD. RP Peters, CJ (reprint author), CTR DIS CONTROL & PREVENT,SPECIAL PATHOGENS BRANCH,DIV VIRAL & RICKETTSIAL DIS,ATLANTA,GA 30341, USA. NR 86 TC 9 Z9 10 U1 0 U2 2 PU SPRINGER-VERLAG WIEN PI VIENNA PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 VIENNA, AUSTRIA SN 0304-8608 J9 ARCH VIROL JI Arch. Virol. PY 1996 SU 11 BP 141 EP 168 PG 28 WC Virology SC Virology GA VD911 UT WOS:A1996VD91100014 ER PT B AU Deal, BM Adams, JS Adams, MH AF Deal, BM Adams, JS Adams, MH GP ASHRAE TI The green neighborhood process: Energy conservation through collaboration SO ASHRAE TRANSACTIONS 1996, VOL 102, PT 2 SE ASHRAE TRANSACTIONS LA English DT Proceedings Paper CT 1996 Annual Meeting of the American-Society-of-Heating-Refrigerating-and-Air-Conditioning-Engineers , Inc CY 1996 CL SAN ANTONIO, TX SP Amer Soc Heating Refrigerating & Air Conditioning Engineers AB Traditional military family housing acquisition, design, and construction procedures have resulted in the procurement of low-end, tract-type housing in neighborhoods that are not energy or resource efficient. In response to this need for greater energy and environmental awareness in the planning, development, and operations of military family housing facilities, the U.S. Army Construction Engineering Research Laboratories have developed the Green Neighborhood/Cool Communities (GN/CC) project. The GN/CC project is designed to develop a prototypical process for constructing family housing neighborhoods that meet the daily needs of the military family while minimizing negative environmental impacts and reducing the general energy consumption of the facilities. A multidisciplinary design team is assembled to integrate current methodologies and technologies that focus on life-cycle costs, the reduction of negative environmental impacts, energy conservation and quality of life improvements in military family housing. Results indicate that the integrated design approach yields increased building energy and resource efficiency at competitive costs. RP Deal, BM (reprint author), USA,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL 61824, USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEATING, REFRIGERATING AND AIR-CONDITIONING ENGS PI ATLANTA PA 1791 TULLIE CIRCLE NE, ATLANTA, GA 30329 J9 ASHRAE TRAN PY 1996 VL 102 BP 699 EP 706 PN 2 PG 8 WC Construction & Building Technology; Engineering, Mechanical SC Construction & Building Technology; Engineering GA BG87V UT WOS:A1996BG87V00079 ER PT B AU Lister, LD Chalifoux, AT Derickson, RG AF Lister, LD Chalifoux, AT Derickson, RG GP ASHRAE TI Energy use and conservation opportunities in army family housing: Results of the fort hood study SO ASHRAE TRANSACTIONS 1996, VOL 102, PT 2 SE ASHRAE TRANSACTIONS LA English DT Proceedings Paper CT 1996 Annual Meeting of the American-Society-of-Heating-Refrigerating-and-Air-Conditioning-Engineers , Inc CY 1996 CL SAN ANTONIO, TX SP Amer Soc Heating Refrigerating & Air Conditioning Engineers AB This work presents the results of a study to determine the energy conservation opportunities and associated cost savings for military family housing located at Fort Hood, Texas. Family housing accounts for about 25% of Fort Hood's total $25.5 million annual energy bill. A variety of issues makes analysis of military housing unique, including the fact that the entire installation (which is a city in virtually every respect) is typically billed as a single entity. Few data are available for individual buildings with which to assess before-retrofit energy use. The methodology employed on-site data collection and verification, fan pressurization studies of 10 dwellings, an hourly simulation-based analysis procedure to determine energy-use patterns, and an energy-use and cost performance analysis of a number of energy conservation opportunities (ECOs). Because Fort Hood housing contributes to, and is thus subject to, the peak demand charge of the entire installation, the analysis of ECO options was performed both on an individual house basis and an installation-wide basis. The latter sewed to illustrate how residential demand pricing strategies can affect decisions for long-range energy planning. Results of the ECO analyses are presented in a tabular format. RP Lister, LD (reprint author), USA,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL 61824, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC HEATING, REFRIGERATING AND AIR-CONDITIONING ENGS PI ATLANTA PA 1791 TULLIE CIRCLE NE, ATLANTA, GA 30329 J9 ASHRAE TRAN PY 1996 VL 102 BP 707 EP 715 PN 2 PG 9 WC Construction & Building Technology; Engineering, Mechanical SC Construction & Building Technology; Engineering GA BG87V UT WOS:A1996BG87V00080 ER PT B AU Chalifoux, AT Lynn, BL McNamee, AR Deal, BM AF Chalifoux, AT Lynn, BL McNamee, AR Deal, BM GP ASHRAE TI The model energy installation program: Progress and lessons learned SO ASHRAE TRANSACTIONS 1996, VOL 102, PT 2 SE ASHRAE TRANSACTIONS LA English DT Proceedings Paper CT 1996 Annual Meeting of the American-Society-of-Heating-Refrigerating-and-Air-Conditioning-Engineers , Inc CY 1996 CL SAN ANTONIO, TX SP Amer Soc Heating Refrigerating & Air Conditioning Engineers AB Executive Order 12902 states that federal facilities shall reduce energy consumption by 30% from 1985 levels by the year 2005. The Army Corps of Engineers instituted the Model Energy Installation Program (MEIP) to investigate the problem associated with scoping and implementing energy-efficient projects on a citywide scale. The site chosen was Fort Hood, Texas, an Army installation with a daytime population of 65,000 and more than 5,200 buildings of all types, ranging from barracks to light commercial to large administrative to vehicle maintenance. This paper outlines the broad scope of the MEIP from a programmatic perspective. It describes the audit efforts undertaken to identify energy-saving projects, the subsequent implementation of those projects, and the problems identified through implementation. It relates how the feedback garnered through project scoping and the implementation provided insight that led to the development of real-world solutions and research products to address the chronic shortage on information, education, and money in the federal government. The lessons learned, projects implemented, and products developed made the MEIP more than just another exercise in spreadsheet engineering. RP Chalifoux, AT (reprint author), USA,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL 61824, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEATING, REFRIGERATING AND AIR-CONDITIONING ENGS PI ATLANTA PA 1791 TULLIE CIRCLE NE, ATLANTA, GA 30329 J9 ASHRAE TRAN PY 1996 VL 102 BP 716 EP 723 PN 2 PG 8 WC Construction & Building Technology; Engineering, Mechanical SC Construction & Building Technology; Engineering GA BG87V UT WOS:A1996BG87V00081 ER PT J AU Cragin, JH Hewitt, AD Colbeck, SC AF Cragin, JH Hewitt, AD Colbeck, SC TI Grain-scale mechanisms influencing the elution of ions from snow SO ATMOSPHERIC ENVIRONMENT LA English DT Article DE chemistry; crystal growth; fractionation; metamorphosis; preferential elution; snowmelt ID PREFERENTIAL ELUTION; ICE; SOLUTE; CHEMISTRY; MELTWATER AB Columns containing synthetic, naturally- or laboratory-aged snow grains were washed with deionized distilled water and with a simulated precipitation solution to investigate both chemical fractionation and preferential ion elution. The resulting elution order and concentrations of Cl-, NO3- and SO42- were not influenced by chromatographic effects, indicating that snow grains do not possess selective affinity for inorganic anions. Fractionation and preferential chemical elution were strongly influenced by ion exclusion and rearrangement processes occurring during dry snow metamorphism, independent of melt-freeze cycles. RP Cragin, JH (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 20 TC 21 Z9 21 U1 0 U2 16 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 1352-2310 J9 ATMOS ENVIRON JI Atmos. Environ. PD JAN PY 1996 VL 30 IS 1 BP 119 EP 127 DI 10.1016/1352-2310(95)00232-N PG 9 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA TK582 UT WOS:A1996TK58200011 ER PT B AU Bosco, CD Su, LP Girolamo, H Darty, M AF Bosco, CD Su, LP Girolamo, H Darty, M GP IEEE TI Maintenance And Repair Support System (MARSS) SO AUTOTESTCON '96 - THE SYSTEM READINESS TECHNOLOGY CONFERENCE: TEST TECHNOLOGY AND COMMERCIALIZATION, CONFERENCE RECORD LA English DT Proceedings Paper CT 32nd Annual AUTOTESTCON - Test Technology and Commercialization (AUTOTESTCON 96) CY SEP 16-19, 1996 CL DAYTON, OH SP IEEE, Aerosp & Electr Syst Soc, IEEE, Instrumentat & Measurement Soc C1 USA,MISSILE COMMAND,TEST MEASUREMENT & DIAGNOST EQUIPMENT ACTIV,REDSTONE ARSENAL,AL 35898. NR 0 TC 0 Z9 0 U1 0 U2 0 PU I E E E PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 BN 0-7803-3380-2 PY 1996 BP 336 EP 343 DI 10.1109/AUTEST.1996.547722 PG 8 WC Engineering, Aerospace; Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA BG39P UT WOS:A1996BG39P00051 ER PT J AU Knutson, SW Dillard, TA Mehm, WJ Phillips, YY AF Knutson, SW Dillard, TA Mehm, WJ Phillips, YY TI Effect of upright and supine posture on hypoxemia during air transport SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID OBSTRUCTIVE PULMONARY-DISEASE; ARTERIAL OXYGENATION AB Background: Change in body position can cause hypoxemia at sea level in patients with lung diseases. Because of concern for the added risk of hypoxemia during air transport, we investigated the effect of body position on arterial oxygen partial pressure (PaO2) in individuals with lung disease under conditions of hypobaric hypoxia. Method: The study groups consisted of 8 patients with chronic obstructive lung disease, 4 patients with interstitial lung disease, and 6 healthy subjects. We obtained samples from radial artery catheters at sea level (SL) and altitude (ALT) simulation of 8000 Ft (2438 m) in a hypobaric chamber in supine and upright postures. Results: Altitude exposure did not result in a significant change in mean supine minus mean upright PaO2 (dPaO(2)); however, some individuals had large changes at SL. Moreover, the variance for dPaO(2), was significantly smaller at ALT compared to SL with all groups combined (F test, p < 0.05). We found no correlation between dPaO(2) at SL vs. ALT (p = 0.293; r = 0.262; n = 18). At both SL and ALT, dPaCO(2) correlated negatively with dpH. At SL, dPaO(2) did not correlate with either dPaCO(2) or dpH; at ALT dPaO(2) correlated with dpH (p < 0.05) and correlated negatively with dPaCO(2) (p < 0.01). Conclusion: We conclude that significantly less postural variation in PaO2 occurs at moderate ALT compared to SL. In our patients with diffuse bilateral pulmonary disease, postural change did not contribute significantly to hypoxemia experienced at ALT. We infer that greater ventilatory response to hypoxemia at ALT in either posture may explain this finding. C1 WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20310. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20310. ARMED FORCES INST PATHOL,WASHINGTON,DC 20306. MADIGAN ARMY MED CTR,TACOMA,WA 98431. NR 15 TC 1 Z9 1 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD JAN PY 1996 VL 67 IS 1 BP 14 EP 18 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA TP715 UT WOS:A1996TP71500004 PM 8929195 ER PT J AU Beale, DG Alem, NM Butler, BP AF Beale, DG Alem, NM Butler, BP TI A correlative investigation of simulated occupant motion and accident report in a helicopter crash SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article AB Background: In the late 1980's, an Army Apache helicopter crashed during a training mission, resulting in fatal injuries to the rear seat pilot and survivable injuries to the front seat copilot. U.S. Army investigators assessed the aircraft damage and aircrew injuries, and examined the helmets, restraint systems, and crashworthy seats. Hypothesis: Computer simulations that approximate an actual crash event can provide insightful output (human body motions and forces on the human body) that illuminates our understanding of the injury dynamics and the effect of safety systems designed to minimize injury. Methods: Crash kinematics and vehicle accelerations were derived from the investigation and inferred from the aircraft damage, and input to a computer-based analytical simulation that calculated the dynamics and forces to which the crew were exposed. Results: We treat the simulation like a looking glass into the event, revealing how and when safety devices could have responded during the crash, and the nature of injury-producing forces experienced by the occupants. Computer simulated whole-body and head-neck motion are graphically displayed, along with plots of joint forces, seat stroke, harness belt acceleration, and occupant accelerations. Conclusions: The calculated motions and forces indicated that injuries found in the accident were likely, hence the simulation may indeed be representative of the actual event. C1 USA,AEROMED RES LAB,FT RUCKER,AL. RP Beale, DG (reprint author), AUBURN UNIV,DEPT MECH ENGN,202 ROSS HALL,AUBURN,AL 36849, USA. NR 10 TC 0 Z9 0 U1 0 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD JAN PY 1996 VL 67 IS 1 BP 23 EP 29 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA TP715 UT WOS:A1996TP71500006 PM 8929197 ER PT S AU Chester, NA Famini, GR Haley, MV Kurnas, CW Sterling, PA Wilson, LY AF Chester, NA Famini, GR Haley, MV Kurnas, CW Sterling, PA Wilson, LY BE Blancato, JN Brown, RN Dary, CC Saleh, MA TI Aquatic toxicity of chemical agent simulants as determined by quantitative structure - Activity relationships and acute bioassays SO BIOMARKERS FOR AGROCHEMICALS AND TOXIC SUBSTANCES: APPLICATIONS AND RISK ASSESSMENT SE ACS SYMPOSIUM SERIES LA English DT Article; Proceedings Paper CT 209th National Meeting of the American-Chemical-Society on Biomarkers for Agrochemicals and Toxic Substances CY APR 02-07, 1995 CL ANAHEIM, CA SP Amer Chem Soc, Div Agrochem ID THEORETICAL DESCRIPTORS; RULES AB Chemical agent simulants (simulants) have been used over the last 30 years to resolve obvious safety issues and provide sources for the development and testing of chemical defense equipment and procedures. In response to increasingly more stringent requirements being placed on the use of the simulants, restrictions involving hazardous waste disposal, and the necessity of performing outdoor tests, a major emphasis has been placed on efforts for determining environmental toxicity and damaging effects. Aquatic bioassays including the Microtox Assay (Photobacterium phosphoreum) and 48 hr Daphnia magna bioassay, were employed to provide preliminary acute toxicity data. A D magna EC(50) QSAR model from the TOPKAT software package and a QSAR model for estimating P. phosphoreum EC(50)s based on the Theoretical Linear Solvation Energy Relationship (TLSER), were used to compare estimates with actual bioassay data. Chemicals tested were chosen from a list of the 70 ''most used'' simulants which include glycols, ethers, acetates, sulfides, organophosphates, and various other chemicals. C1 LA SIERRA UNIV,DEPT CHEM,RIVERSIDE,CA 92515. RP Chester, NA (reprint author), USA,EDGEWOOD RES,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010, USA. NR 29 TC 3 Z9 3 U1 1 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 SN 0097-6156 BN 0-8412-3449-3 J9 ACS SYM SER PY 1996 VL 643 BP 191 EP 204 PG 14 WC Agronomy; Chemistry, Applied; Environmental Sciences; Toxicology SC Agriculture; Chemistry; Environmental Sciences & Ecology; Toxicology GA BG42D UT WOS:A1996BG42D00015 ER PT B AU Chen, ZP Gao, H Kumar, J Marx, KA Tripathy, SK Kaplan, DL AF Chen, ZP Gao, H Kumar, J Marx, KA Tripathy, SK Kaplan, DL BE Lieberman, RA Podbielska, H VoDinh, T TI Molecular assembly of multilayer enzyme on fiber optic surface: Towards the development of Chemiluminescence based fiber optic biosensors SO BIOMEDICAL SENSING, IMAGING, AND TRACKING TECHNOLOGIES I SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Biomedical Sensing, Imaging, and Tracking Technologies I CY JAN 29-31, 1996 CL SAN JOSE, CA SP Soc Photo Opt Instrumentat Engineers DE biosensors; molecular assembly; optical fiber sensor; chemiluminescence; pesticide C1 USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760. NR 0 TC 1 Z9 1 U1 0 U2 0 PU SPIE - INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 BN 0-8194-2050-6 J9 P SOC PHOTO-OPT INS PY 1996 VL 2676 BP 156 EP 164 DI 10.1117/12.238794 PG 9 WC Engineering, Biomedical; Optics SC Engineering; Optics GA BF60S UT WOS:A1996BF60S00018 ER PT J AU Sellin, LC Mattila, K Annila, A Schmidt, JJ McArdle, JJ Hyvonen, M Rantala, TT Kivisto, T AF Sellin, LC Mattila, K Annila, A Schmidt, JJ McArdle, JJ Hyvonen, M Rantala, TT Kivisto, T TI Conformational analysis of a toxic peptide from Trimeresurus wagleri which blocks the nicotinic acetylcholine receptor SO BIOPHYSICAL JOURNAL LA English DT Article ID LETHAL PEPTIDES; PIT VIPER; VENOM; DYNAMICS; MUSCLE AB The 22-residue toxic peptide (WTX1) from the venom of the Southeast Asian snake Trimeresurus wagleri has multiple sites of action, but its lethal effect has been attributed to blocking the postsynaptic acetylcholine receptor at the neuromuscular junction. The 3-dimensional structure of WTX1 was studied using 2-dimensional nuclear magnetic resonance spectroscopy, circular dichroism, and computer simulations, In aqueous solution, WTX1 was shown to have extended and flexible ''tails'' defined by a short, rigid disulfide-bonded loop. The flexible regions can undergo structural rearrangement when moved from an aqueous to a less polar environment and may contribute to its effectiveness at different receptor sites, By substituting Gly or Phe for His at position 10, significant effects on the disulfide bond formation and, thereby, the activity of the peptide were observed, These results suggest that even subtle differences in single residues can have profound effects on the dynamics of folding, disulfide bond formation, and activity of this toxic peptide. C1 OULU UNIV,DEPT PHYS SCI,DIV PHYS,SF-90570 OULU,FINLAND. CHEM TECHNOL STATE TECH RES CTR FINLAND,SF-02150 ESPOO,FINLAND. USA,MED RES INST INFECT DIS,DIV TOXICOL,FREDERICK,MD 21702. UNIV MED & DENT NEW JERSEY,NEW JERSEY MED SCH,DEPT PHARMACOL & TOXICOL,NEWARK,NJ 07103. RP Sellin, LC (reprint author), OULU UNIV,DEPT PHYS SCI,DIV BIOPHYS,SF-90570 OULU,FINLAND. FU NINDS NIH HHS [NS 31040] NR 23 TC 13 Z9 14 U1 2 U2 2 PU BIOPHYSICAL SOCIETY PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0006-3495 J9 BIOPHYS J JI Biophys. J. PD JAN PY 1996 VL 70 IS 1 BP 3 EP 13 PG 11 WC Biophysics SC Biophysics GA TY683 UT WOS:A1996TY68300001 PM 8770182 ER PT J AU Krishnamurti, C Keyt, B Maglasang, P Alving, BM AF Krishnamurti, C Keyt, B Maglasang, P Alving, BM TI PAI-1-resistant t-PA: Low doses prevent fibrin deposition in rabbits with increased PAI-1 activity SO BLOOD LA English DT Article ID PLASMINOGEN-ACTIVATOR INHIBITOR-1; KHRR-296-299 AAAA; PLASMA; RESISTANT; VARIANT; ANCROD; T103N AB The present study compared the activities of recombinant tissue-type plasminogen activator (t-PB) and a plasminogen activator inhibitor-1 (PAI-1)-resistant variant t-PA (Kt-PA, KHRR 296-299 AAAA) in preventing renal fibrin deposition in rabbits with elevated PAI-1 activity. In this model, all rabbits were infused with endotoxin (10 mu g/kg), followed by initiation of thrombin (130 U/kg) 4 hours later, when plasma PAI-1 activity was greater than 200 arbitrary units (AU)/mL (baseline, <3 AU/mL. Thirty minutes after completion of the 1-hour thrombin infusion, rabbits were killed and the kidneys fixed and stained for identification of fibrin deposition. Rabbits received one of the following treatments initiated 30 minutes before thrombin and continued during the 1-hour thrombin infusion: (1) saline (n = 7); (2) low-dose t-PA (17 mu g/kg, n = 4); (3) higher-dose t-PA (170 mu g/kg, n = 4); or (4) low-dose Kt-PA (17 mu g/kg, n = 6). Fibrin deposition occurred in 86% and 100% of the rabbits receiving saline or low-dose t-PA, respectively. Fibrin deposition did not occur in any of the rabbits receiving low-dose Kt-PA or higher-dose t-PA. Low-dose Kt-PA and higher dose t-PA also caused a reduction in fibrin deposition when infused after thrombin administration had been completed. The data provide in vivo evidence that Kt-PA is more effective than t-PA in preventing fibrin deposition in an animal model that combines thrombogenic stimulation with increased PAI-1 activity. This is a US government work. There are no restrictions on its use. C1 GENENTECH INC,CARDIOVASC RES,S SAN FRANCISCO,CA 94080. RP Krishnamurti, C (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT HEMATOL & VASC BIOL,WASHINGTON,DC 20307, USA. NR 22 TC 10 Z9 10 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD JAN 1 PY 1996 VL 87 IS 1 BP 14 EP 19 PG 6 WC Hematology SC Hematology GA TN441 UT WOS:A1996TN44100002 PM 8547635 ER PT J AU Yee, E Chan, R Kosteniuk, PR Biltoft, CA Bowers, JF AF Yee, E Chan, R Kosteniuk, PR Biltoft, CA Bowers, JF TI Multiscaling properties of concentration fluctuations in dispersing plumes revealed using an orthonormal wavelet decomposition SO BOUNDARY-LAYER METEOROLOGY LA English DT Article ID BOUNDARY-LAYER; DENSITY-ESTIMATION; TURBULENCE; REPRESENTATION; TRANSFORMS; ATMOSPHERE; CASCADE AB The dynamical characteristics of concentration fluctuations in a dispersing plume over the energetic and inertial-convective range of scales of turbulent motion are studied using a multiscale analysis technique that is based on an orthonormal wavelet representation. It is shown that the Haar wavelet concentration spectrum is similar to the Fourier concentration spectrum in that both spectra exhibit an extensive inertial-convective subrange spanning about two decades in frequency, with a scaling exponent of -5/3. Analysis of the statistical properties (e.g., fluctuation intensity, skewness, and kurtosis) of the concentration wavelet coefficients (i.e., the concentration discrete detailed signal) suggests that the small scales are always more intermittent than the large scales. The degree of intermittency increases monotonically with decreasing scale within the inertial-convective subrange, reaching a plateau at the very small scales associated with the beginning of the near-dissipation subrange. The probability density function (pdf) of the concentration discrete detailed signal displays stretched exponential tails with an intermittency exponent (tail slope) q that increases as tau(a), where tau is the scale or dilation and a is a power-law exponent that is dependent on downwind distance, plume height, and stratification strength with typical values in the range from about 0.25 to 0.35. It is shown that the concentration variance cascade process requires a phase coherency of eddies between different scales at the small-scale end of the inertial-convective subrange. The variation of the concentration wavelet statistics with height above the ground is investigated. The increased mean shear near the ground smooths the fine-scale plume structure for scales within the inertial-convective subrange, producing a weaker spatiotemporal intermittency in the concentration field compared to that measured higher up in the plume. The pdf of the concentration detailed signal at a fixed scale possesses less elongated tails with decreasing height z. The intermittency exponent q is found to decrease roughly linearly with increasing z. Finally, the results of the wavelet decomposition are combined to provide a conceptual model of the turbulent transport, stirring, and mixing regimes in a dispersing plume. The implications of the results for contaminant texture in a plume are discussed. C1 KOSTENIUK CONSULTING LTD,SASKATOON,SK S7K 0H2,CANADA. USA,DUGWAY PROVING GROUND,W DESERT TEST CTR,METEOROL DIV,DUGWAY PROVING GROUND,UT 84022. RP Yee, E (reprint author), DEF RES ESTAB SUFFIELD,POB 4000,MEDICINE HAT,AB T1A 8K6,CANADA. NR 43 TC 5 Z9 5 U1 0 U2 0 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0006-8314 J9 BOUND-LAY METEOROL JI Bound.-Layer Meteor. PD JAN PY 1996 VL 77 IS 2 BP 173 EP 207 DI 10.1007/BF00119577 PG 35 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA UN224 UT WOS:A1996UN22400004 ER PT J AU Stillman, MJ ShukittHale, B Galli, RL Levy, A Lieberman, HR AF Stillman, MJ ShukittHale, B Galli, RL Levy, A Lieberman, HR TI Effects of M(2) antagonists on in vivo hippocampal acetylcholine levels SO BRAIN RESEARCH BULLETIN LA English DT Article DE microdialysis; muscarinic; cholinergic system; choline; presynaptic receptor; HPLC-EC ID MUSCARINIC RECEPTOR SUBTYPES; RAT-BRAIN; ALZHEIMERS-DISEASE; RELEASE; MEMORY; MICRODIALYSIS; STRIATUM; PHYSOSTIGMINE; HETEROGENEITY; METHOCTRAMINE AB There is evidence that muscarinic receptors of the M(2) subtype are presynaptic autoreceptors that modify the release of acetylcholine (ACh) through a negative feedback mechanism. Blocking these receptors by selective antagonists may therefore lead to increased ACh release, This in vivo microdialysis study examined the effects of three M(2) antagonists, AF-DX 116, AF-DX 384, and AQ-RA 741, on hippocampal cholinergic neurotransmission. Drug (2, 4, 8, or 16 mu M) or vehicle (Ringer's solution) was perfused via a microdialysis probe into the CA1 hippocampal region of conscious male Fischer 344 rats, Levels of ACh and choline were assessed by HPLC-EC. When the dose was expressed in K-i multiples, all drugs (except AQ-RA 741 at the two highest concentrations) were found to be on the same linear dose-response curve. Choline levels were not affected by drug administration. All three compounds elevated ACh levels in a similar K-i-normalized dose-response fashion, strongly supporting the concept that the proposed presynaptic mechanism of action is indeed based on the same M(2) receptor. Such elevations of ACh may not only improve performance on memory tasks, but may also have therapeutic advantages in conditions of cholinergic hypofunction, such as Alzheimer's disease. Copyright (C) 1996 Elsevier Science Inc. C1 USA,ENVIRONM MED RES INST,MIL PERFORMANCE & NEUROSCI DIV,NATICK,MA 01760. ISRAEL INST BIOL RES,DEPT PHARMACOL,IL-70450 NESS ZIONA,ISRAEL. GEOCENTERS INC,NEWTON,MA 02159. NR 33 TC 30 Z9 31 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0361-9230 J9 BRAIN RES BULL JI Brain Res. Bull. PY 1996 VL 41 IS 4 BP 221 EP 226 DI 10.1016/S0361-9230(96)00180-3 PG 6 WC Neurosciences SC Neurosciences & Neurology GA VR270 UT WOS:A1996VR27000004 PM 8924031 ER PT J AU Palmer, DR Bradley, M Bundy, DA AF Palmer, DR Bradley, M Bundy, DA TI IgG4 responses to antigens of adult Necator americanus: Potential for use in large-scale epidemiological studies SO BULLETIN OF THE WORLD HEALTH ORGANIZATION LA English DT Article ID PAPUA-NEW-GUINEA; POPULATION BIOLOGY; ANTIBODY-RESPONSES; INFECTION; COMMUNITY; REINFECTION AB Described is an epidemiological investigation of hookworm infections in a rural community in Zimbabwe, where Necator americanus is the only human helminth species present. Among a cohort of 120 individuals the overall prevalence of infection was 78%. Intensity of infection was quantified both as egg counts (range: 0-2563 eggs per g of stool) and worm burden (range: 0-100 worms). Although both these measures provide useful quantitative data, they are tedious to determine in large-scale epidemiological studies and may present social and logistic difficulties. As an alternative screening method, we therefore investigated isotype-specific responses to adult worm antigens of N. americanus. The results show that specific IgG4 responses correlate positively and significantly with both measures of intensify and may be a useful marker of hookworm infection. C1 BLAIR RES INST,HARARE,ZIMBABWE. UNIV OXFORD,DEPT ZOOL,WHO,COLLABORATING CTR EPIDEMIOL INFECT DIS,OXFORD OX1 3PS,ENGLAND. RP Palmer, DR (reprint author), WALTER REED ARMY INST RES,DEPT IMMUNOL,BLDG 40,14TH & DAHLIA ST NW,WASHINGTON,DC 20307, USA. FU Wellcome Trust NR 18 TC 22 Z9 22 U1 0 U2 0 PU WORLD HEALTH ORGANIZATION PI GENEVA 27 PA DISTRIBUTION AND SALES, CH-1211 GENEVA 27, SWITZERLAND SN 0042-9686 J9 B WORLD HEALTH ORGAN JI Bull. World Health Organ. PY 1996 VL 74 IS 4 BP 381 EP 386 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA VF120 UT WOS:A1996VF12000006 PM 8823959 ER PT S AU Hsieh, BB AF Hsieh, BB BE Kovar, K vanderHeijde, P TI System response approach for improving calibration and reliability in multidimensional groundwater modelling SO CALIBRATION AND RELIABILITY IN GROUNDWATER MODELLING SE IAHS PUBLICATIONS LA English DT Proceedings Paper CT ModelCARE 96 Conference - Calibration and Reliability in Groundwater Modelling CY SEP 24-26, 1996 CL GOLDEN, CO SP Int Ground Water Modeling Ctr, Int Assoc Hydrol Sci, Int Commiss Groundwater, Int Assoc Hydrogeologists AB A system response approach which uses Fourier transform through a multiple-input/single-output (MISO) nonlinear system to evaluate the groundwater numerical model performance of calibration and simulation reliability has been developed. This approach offers more insight into the actual physical behaviour than the traditional statistical method does. To improve simulation reliability, a computational procedure was derived to examine model sensitivity and reduce uncertainty. The application showed that this approach proved to be an excellent tool for quantitatively evaluating the model performance and obtaining more reliable simulation results. RP Hsieh, BB (reprint author), USA,WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INT ASSOC HYDROLOGICAL SCIENCES PI WALLINGFORD PA INST OF HYDROLOGY, WALLINGFORD, ENGLAND OX10 8BB SN 0144-7815 BN 0-947571-94-9 J9 IAHS-AISH P PY 1996 IS 237 BP 579 EP 588 PG 10 WC Geosciences, Multidisciplinary SC Geology GA BG73H UT WOS:A1996BG73H00057 ER PT J AU Lei, J Payne, BS Wang, SY AF Lei, J Payne, BS Wang, SY TI Filtration dynamics of the zebra mussel, Dreissena polymorpha SO CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES LA English DT Article ID SUSPENSION-FEEDING BIVALVES; MYTILUS-EDULIS; ALGAL CONCENTRATION; PARTICLE RETENTION; RATES; TEMPERATURE; EFFICIENCY; LAKES; POPULATION; QUANTITY AB We quantified the effects of particle type, size, and concentration, mussel size, and temperature on filter-feeding rates of Dreissena polymorpha (Bivalvia). Experiments using plastic microspheres yielded reliable filtration estimates when measurements were made prior to the onset of feces production. Once filtered material passed through the gut, filtration of microspheres was much slower than filtration of natural seston. Particles equal to or greater than 1.5 mu m in diameter were retained with nearly total efficiency. Clearance rates (mL . h(-1)) were maintained at a maximum level at particle concentrations less than 27 mg . L(-1) Filtration rates (mg . h(-1)) stabilized at a maximum level above 27 mg . L(-1). The onset of pseudofeces production, indicating overload of the filtration apparatus, also occurred in the majority of mussels at approximately 27 mg . L(-1). Filtration per unit gill area was constant regardless of mussel size. Optimal filtration occurred between 14 and 26 degrees C. The filtration Q(10) (8-20 degrees C) equaled 2.4 and 1.7 for cold- and warm-acclimated mussels, respectively. Similarly, the Q(10) (8-22 degrees C) of the beat rates of lateral cilia and laterofrontal cirri equaled 2.0. At a common temperature and adjusted for body size, clearance rates of D. polymorpha were equal to rates reported for other freshwater bivalves, indicating functional similarity between them. C1 UNIV SO MISSISSIPPI,DEPT BIOL SCI,HATTIESBURG,MS 39406. USA,ENGINEER WATERWAYS EXPT STN,ENVIRONM LAB,VICKSBURG,MS 39180. RP Lei, J (reprint author), LOUISIANA DEPT TRANSPORTAT,5040 FLORIDA BLVD,ROOM 205,POB 94245,BATON ROUGE,LA 70804, USA. NR 57 TC 71 Z9 76 U1 1 U2 25 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A 0R6, CANADA SN 0706-652X J9 CAN J FISH AQUAT SCI JI Can. J. Fish. Aquat. Sci. PD JAN PY 1996 VL 53 IS 1 BP 29 EP 37 DI 10.1139/cjfas-53-1-29 PG 9 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA UB979 UT WOS:A1996UB97900003 ER PT J AU Steedman, RJ Whillans, TH Behm, AP Bray, KE Cullis, KI Holland, MM Stoddart, SJ White, RJ AF Steedman, RJ Whillans, TH Behm, AP Bray, KE Cullis, KI Holland, MM Stoddart, SJ White, RJ TI Use of historical information for conservation and restoration of Great Lakes aquatic habitat SO CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES LA English DT Article; Proceedings Paper CT Workshop on the Science and Management for Habitat Conservation and Restoration Strategies (HabCARES) in the Great Lakes CY NOV, 1994 CL KEMPENFELT, CANADA ID MANAGEMENT; INTEGRITY; COMMUNITIES; SEDIMENTS; QUANTIFY; ONTARIO; ERIE AB We provide a rationale and methodological overview for historical (retrospective) study of Great Lakes aquatic habitats and biota. Historical information has significant potential to direct aquatic habitat management in the Great Lakes, particularly in setting restoration goals. Although the use of historical information has been opportunistic (it is limited by the preservation of information in specific forms) and generally of low resolution (it is generally semiquantitative at best), the products of these analyses have been compelling (they have changed the attitudes and expectations of people) and surprising (many of the conclusions of historical analysis were not predictable from other sources). C1 TRENT UNIV,ENVIRONM & RESOURCE STUDIES PROGRAM,PETERBOROUGH,ON K9J 7B8,CANADA. USA,CORPS ENGINEERS,PLANNING DIV,CHICAGO,IL 60606. ONTARIO MINIST ENVIRONM & ENERGY,ENVIRONM CANADA,LAKE SUPERIOR PROGRAMS OFF,THUNDER BAY,ON P7B 5E3,CANADA. ONTARIO MINIST NAT RESOURCES,LAKE SUPERIOR PROGRAMS OFF,THUNDER BAY,ON P7B 5E3,CANADA. UNIV MISSISSIPPI,DEPT BIOL,UNIVERSITY,MS 38677. FISHERIES & OCEANS CANADA,GREAT LAKES LAB FISHERIES & AQUAT SCI,SAULT ST MARIE,ON P6A 6W4,CANADA. TROUT HABITAT SPECIALISTS,EDMONDS,WA 98020. RP Steedman, RJ (reprint author), ONTARIO MINIST NAT RESOURCES,CTR NO FOREST ECOSYST RES,955 OLIVER RD,THUNDER BAY,ON P7B 5E1,CANADA. NR 88 TC 14 Z9 15 U1 3 U2 7 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A 0R6, CANADA SN 0706-652X J9 CAN J FISH AQUAT SCI JI Can. J. Fish. Aquat. Sci. PY 1996 VL 53 SU 1 BP 415 EP 423 DI 10.1139/cjfas-53-S1-415 PG 9 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA VK062 UT WOS:A1996VK06200036 ER PT J AU Solimando, DA Phillips, ET Weiss, RB Dawson, NA Diehl, LF Rickles, NM AF Solimando, DA Phillips, ET Weiss, RB Dawson, NA Diehl, LF Rickles, NM TI Hypertensive reactions associated with paclitaxel SO CANCER INVESTIGATION LA English DT Article C1 US FDA,OFF ESTAB LICENSING & PROD SURVEILLANCE,ROCKVILLE,MD 20857. WALTER REED ARMY MED CTR,DEPT MED,HEMATOL ONCOL SERV,WASHINGTON,DC 20307. RP Solimando, DA (reprint author), THOMAS JEFFERSON UNIV HOSP,DEPT PHARM,ROOM 1830G,111 S 11TH ST,PHILADELPHIA,PA 19107, USA. NR 3 TC 4 Z9 4 U1 0 U2 0 PU MARCEL DEKKER INC PI NEW YORK PA 270 MADISON AVE, NEW YORK, NY 10016 SN 0735-7907 J9 CANCER INVEST JI Cancer Invest. PY 1996 VL 14 IS 4 BP 340 EP 342 DI 10.3109/07357909609012161 PG 3 WC Oncology SC Oncology GA UY225 UT WOS:A1996UY22500008 PM 8689429 ER PT J AU Diehl, LF Bolan, CD Weiss, RB AF Diehl, LF Bolan, CD Weiss, RB TI Hemolytic anemia and cancer SO CANCER TREATMENT REVIEWS LA English DT Review ID CHRONIC LYMPHOCYTIC-LEUKEMIA; BONE-MARROW TRANSPLANTATION; T-CELL LYMPHOMA; HISTIOCYTIC MEDULLARY RETICULOSIS; EPSTEIN-BARR-VIRUS; DIRECT ANTIGLOBULIN-TEST; MITOMYCIN-C THERAPY; SIMULATING MALIGNANT HISTIOCYTOSIS; REACTIVE HEMOPHAGOCYTIC SYNDROME; ACUTE LYMPHOBLASTIC-LEUKEMIA C1 UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20815. RP Diehl, LF (reprint author), WALTER REED ARMY MED CTR,DEPT MED,HEMATOL ONCOL SERV,WASHINGTON,DC 20307, USA. NR 298 TC 2 Z9 2 U1 0 U2 2 PU W B SAUNDERS CO LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0305-7372 J9 CANCER TREAT REV JI Cancer Treat. Rev. PD JAN PY 1996 VL 22 IS 1 BP 33 EP 73 DI 10.1016/S0305-7372(96)90015-8 PG 41 WC Oncology SC Oncology GA UJ281 UT WOS:A1996UJ28100003 PM 8625331 ER PT S AU Zajtchuk, R Dasey, C Clyburn, C AF Zajtchuk, R Dasey, C Clyburn, C BE Lemke, HU Vannier, MW Inamura, K Farman, AG TI The department of defense telemedicine testbed: Research, practice, opportunities SO CAR '96: COMPUTER ASSISTED RADIOLOGY SE INTERNATIONAL CONGRESS SERIES LA English DT Proceedings Paper CT International Symposium on Computer and Communication Systems for Image Guided Diagnosis and Therapy (CAR 96) CY JUN, 1996 CL PARIS, FRANCE RP Zajtchuk, R (reprint author), USA,MED RES & MAT COMMAND,HEADQUARTERS,FT DETRICK,MD 21702, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE PUBL B V PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0531-5131 BN 0-444-82497-9 J9 INT CONGR SER PY 1996 VL 1124 BP 511 EP 514 PG 4 WC Engineering, Biomedical; Medical Informatics; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Medical Informatics; Radiology, Nuclear Medicine & Medical Imaging GA BG22F UT WOS:A1996BG22F00089 ER PT S AU Vandre, RH AF Vandre, RH BE Lemke, HU Vannier, MW Inamura, K Farman, AG TI Fundamentals of digital dental radiographic imaging SO CAR '96: COMPUTER ASSISTED RADIOLOGY SE INTERNATIONAL CONGRESS SERIES LA English DT Proceedings Paper CT International Symposium on Computer and Communication Systems for Image Guided Diagnosis and Therapy (CAR 96) CY JUN, 1996 CL PARIS, FRANCE RP Vandre, RH (reprint author), WALTER REED ARMY INST RES,USA DENT RES DETACHMENT,WRAMC,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE PUBL B V PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0531-5131 BN 0-444-82497-9 J9 INT CONGR SER PY 1996 VL 1124 BP 873 EP 879 PG 7 WC Engineering, Biomedical; Medical Informatics; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Medical Informatics; Radiology, Nuclear Medicine & Medical Imaging GA BG22F UT WOS:A1996BG22F00152 ER PT S AU Vandre, RH Pajak, JC AF Vandre, RH Pajak, JC BE Lemke, HU Vannier, MW Inamura, K Farman, AG TI Technical evaluation of the Dexis, intraoral dental x-ray sensor SO CAR '96: COMPUTER ASSISTED RADIOLOGY SE INTERNATIONAL CONGRESS SERIES LA English DT Proceedings Paper CT International Symposium on Computer and Communication Systems for Image Guided Diagnosis and Therapy (CAR 96) CY JUN, 1996 CL PARIS, FRANCE RP Vandre, RH (reprint author), WALTER REED ARMY INST RES,USA,WRAMC,DENT RES DETACHMENT,WASHINGTON,DC 20307, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE PUBL B V PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0531-5131 BN 0-444-82497-9 J9 INT CONGR SER PY 1996 VL 1124 BP 963 EP 968 PG 6 WC Engineering, Biomedical; Medical Informatics; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Medical Informatics; Radiology, Nuclear Medicine & Medical Imaging GA BG22F UT WOS:A1996BG22F00170 ER PT S AU Kim, HJ Taub, IA Choi, YM Prakash, A AF Kim, HJ Taub, IA Choi, YM Prakash, A BE Lee, TC Kim, HJ TI Principles and applications of chemical markers of sterility in high temperature short-time processing of particulate foods SO CHEMICAL MARKERS FOR PROCESSED AND STORED FOODS SE ACS SYMPOSIUM SERIES LA English DT Article; Proceedings Paper CT Symposium on Chemical Markers for Processed and Stored Foods, at the 210th National Meeting of the American-Chemical-Society CY AUG 20-24, 1995 CL CHICAGO, IL SP Amer Chem Soc, Div Agr & Food Chem ID BEEF FLAVOR; D-GLUCOSE; 4-HYDROXY-5-METHYL-3(2H)-FURANONE; COMPONENT; PRODUCTS; ACID; CONSTITUENTS AB Continuous sterilization and aseptic packaging technologies have a great deal of potential to produce shelf-stable foods in convenient packages. A direct measurement of time-temperature history within food particulates is not practical in continuous, high temperature/short time (HTST) processes. The yield of thermally produced compounds offers an alternative as a time temperature integrator and as a chemical marker of sterility. One such a compound, 2,3-dihydro-3,5-dihydroxy-6-methyl-4(H)-pyran-4-one (M-1), is formed at sterilizing temperatures from D-glucose or D-fructose and amines through 2,3-enolization under weakly acidic or neutral conditions. Another marker, 4-hydroxy-5-methyl-3(2H)-furanone (M-2), is formed similarly from D-ribose or D-ribose-5-phosphate, Application of these compounds to mapping lethality distribution within food particulates in two volumetric heating processes, ohmic heating and microwave sterilization is demonstrated. C1 KOREA UNIV,INST BIOTECHNOL,SEOUL 136701,SOUTH KOREA. OHIO STATE UNIV,DEPT FOOD SCI & TECHNOL,COLUMBUS,OH 43210. RP Kim, HJ (reprint author), USA,NATICK RES DEV & ENGN CTR,KANSAS ST,NATICK,MA 01760, USA. NR 58 TC 1 Z9 1 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 SN 0097-6156 BN 0-8412-3404-3 J9 ACS SYM SER PY 1996 VL 631 BP 54 EP 69 PG 16 WC Chemistry, Applied; Chemistry, Analytical; Food Science & Technology SC Chemistry; Food Science & Technology GA BG76E UT WOS:A1996BG76E00006 ER PT J AU Lipnick, RN Iliopoulos, A Salata, K Hershey, J Melnick, D Tsokos, GC AF Lipnick, RN Iliopoulos, A Salata, K Hershey, J Melnick, D Tsokos, GC TI Leukocyte adhesion deficiency: Report of a case and review of the literature SO CLINICAL AND EXPERIMENTAL RHEUMATOLOGY LA English DT Article DE leukocyte adhesion deficiency; beta 2 integrins; leukocyte adhesion molecules ID RECURRENT BACTERIAL-INFECTIONS; DELAYED SEPARATION; UMBILICAL-CORD; WIDESPREAD INFECTIONS; SURFACE EXPRESSION; GLYCOPROTEIN; MOLECULES; LFA-1; CD18; MAC-1 AB Leukocyte adhesion deficiency (LAD) is a rare inherited immunodeficiency that is characterized by deficiency of the beta 2 integrin leukocyte adhesion molecules Mac-1, LFA-1, and p150,95. We describe a case of the severe form of LAD in an infant with recurrent infections and with a complete deficiency of beta 2 integrin molecules, and review the clinical aspects of the syndrome. C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. FAIRFAX HOSP CHILDREN,DEPT PEDIAT,FALLS CHURCH,VA. NR 25 TC 12 Z9 12 U1 0 U2 0 PU CLINICAL & EXPER RHEUMATOLOGY PI PISA PA VIA SANTA MARIA 31, 56126 PISA, ITALY SN 0392-856X J9 CLIN EXP RHEUMATOL JI Clin. Exp. Rheumatol. PD JAN-FEB PY 1996 VL 14 IS 1 BP 95 EP 98 PG 4 WC Rheumatology SC Rheumatology GA UB310 UT WOS:A1996UB31000017 PM 8697667 ER PT J AU Caldwell, CM Shanley, DJ Gayle, EL AF Caldwell, CM Shanley, DJ Gayle, EL TI Renal artery stenosis secondary to Takayasu's arteritis demonstrated on Tc-99m MAG3 renal scan correlation with conventional angiography SO CLINICAL NUCLEAR MEDICINE LA English DT Article RP Caldwell, CM (reprint author), TRIPLER ARMY MED CTR,DEPT RADIOL,DIV NUCL MED,HONOLULU,HI 96859, USA. NR 2 TC 1 Z9 1 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD JAN PY 1996 VL 21 IS 1 BP 76 EP 77 DI 10.1097/00003072-199601000-00025 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA TQ377 UT WOS:A1996TQ37700025 PM 8741903 ER PT J AU Ryan, ME Webster, ML Statler, JD AF Ryan, ME Webster, ML Statler, JD TI Adverse effects of intravenous immunoglobulin therapy SO CLINICAL PEDIATRICS LA English DT Review ID NON-B-HEPATITIS; ACUTE ASEPTIC-MENINGITIS; IMMUNE GLOBULIN; GAMMA-GLOBULIN; NON-A; RENAL-FAILURE; THROMBOTIC EVENTS; TOXICITY; SAFETY; THROMBOCYTOPENIA C1 AKRON CHILDRENS HOSP,DEPT GEN PEDIAT,AKRON,OH. WALTER REED ARMY MED CTR,DEPT GEN PEDIAT,WASHINGTON,DC 20307. RP Ryan, ME (reprint author), GEISINGER MED CTR,DEPT PEDIAT,100 N ACAD AVE,DANVILLE,PA 17822, USA. NR 62 TC 32 Z9 33 U1 0 U2 2 PU WESTMINSTER PUBL INC PI GLEN HEAD PA 708 GLEN COVE AVE, GLEN HEAD, NY 11545 SN 0009-9228 J9 CLIN PEDIATR JI Clin. Pediatr. PD JAN PY 1996 VL 35 IS 1 BP 23 EP 31 DI 10.1177/000992289603500105 PG 9 WC Pediatrics SC Pediatrics GA TP923 UT WOS:A1996TP92300005 PM 8825847 ER PT B AU Smith, JM Svendsen, IA AF Smith, JM Svendsen, IA BE Dally, WR Zeidler, RB TI Modeling time- and depth-varying currents at supertank SO COASTAL DYNAMICS '95 LA English DT Proceedings Paper CT International Conference on Coastal Research in Terms of Large Scale Experiments CY SEP 04-08, 1995 CL GDANSK, POLAND SP Polish Acad Sci, Inst Hydro Engn, CIIRC Barcelona, Gdansk Millennium Comm, Gdansk Voivodship, Hydrobudowa SA, Gdynia Inst Meterol & Water Management, Maritime Inst Gdansk, City Council & Mayor Gdynia, Minist Transport & Maritime Econ, Polish Acad Sci, Polish Airlines, Polish Comm Sci Res, MAST G 8M, Amer Soc Civil Engineers C1 USA,ENGINEER WATERWAYS EXPT STN,COASTAL ENGN RES CTR,VICKSBURG,MS 39180. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CIVIL ENGINEERS PI NEW YORK PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 BN 0-7844-0154-3 PY 1996 BP 245 EP 256 PG 12 WC Engineering, Marine; Engineering, Civil SC Engineering GA BF42H UT WOS:A1996BF42H00021 ER PT B AU Rosati, JD Hamilton, DG Fowler, JE Smith, JM AF Rosati, JD Hamilton, DG Fowler, JE Smith, JM BE Dally, WR Zeidler, RB TI Design of a laboratory facility for longshore sediment transport research SO COASTAL DYNAMICS '95 LA English DT Proceedings Paper CT International Conference on Coastal Research in Terms of Large Scale Experiments CY SEP 04-08, 1995 CL GDANSK, POLAND SP Polish Acad Sci, Inst Hydro Engn, CIIRC Barcelona, Gdansk Millennium Comm, Gdansk Voivodship, Hydrobudowa SA, Gdynia Inst Meterol & Water Management, Maritime Inst Gdansk, City Council & Mayor Gdynia, Minist Transport & Maritime Econ, Polish Acad Sci, Polish Airlines, Polish Comm Sci Res, MAST G 8M, Amer Soc Civil Engineers C1 USAE,WATERWAYS EXPT STN,COASTAL ENGN RES CTR,VICKSBURG,MS 39180. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC CIVIL ENGINEERS PI NEW YORK PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 BN 0-7844-0154-3 PY 1996 BP 771 EP 782 PG 12 WC Engineering, Marine; Engineering, Civil SC Engineering GA BF42H UT WOS:A1996BF42H00067 ER PT B AU Gurd, ED Forest, CA AF Gurd, ED Forest, CA BE Hopper, DG TI Flat panels in future ground combat vehicles SO COCKPIT DISPLAYS III SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Cockpit Displays III CY APR 10-11, 1996 CL ORLANDO, FL SP Soc Photo Opt Instrumentat Engineers DE multifunction displays; helmet mounted displays; panoramic displays C1 USA,TANK AUTOMOT & ARMAMENTS COMMAND,WARREN,MI 48397. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPIE - INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 BN 0-8194-2115-4 J9 P SOC PHOTO-OPT INS PY 1996 VL 2734 BP 127 EP 134 DI 10.1117/12.240995 PG 8 WC Computer Science, Cybernetics; Ergonomics; Optics SC Computer Science; Engineering; Optics GA BF76P UT WOS:A1996BF76P00015 ER PT B AU Bowden, CM Manka, AS Dowling, JP Fleischhauer, M AF Bowden, CM Manka, AS Dowling, JP Fleischhauer, M BE Eberly, JH Mandel, L Wolf, E TI Local field effects in nonlinear and quantum optics SO COHERENCE AND QUANTUM OPTICS VII LA English DT Proceedings Paper CT 7th Rochester Conference on Coherence and Quantum Optics CY JUN 07-10, 1995 CL UNIV ROCHESTER, ROCHESTER, NY SP Amer Phys Soc, Opt Soc Amer, Int Union Pure & Appl Phys, Univ Rochester HO UNIV ROCHESTER C1 USA,MISSILE COMMAND,WEAP SCI DIRECTORATE,AMSMI,RD,WS,ST,RES DEV & ENGN CTR,REDSTONE ARSENAL,AL 35898. RI Fleischhauer, Michael/G-6716-2011 NR 0 TC 2 Z9 2 U1 0 U2 0 PU PLENUM PRESS DIV PLENUM PUBLISHING CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 BN 0-306-45314-2 PY 1996 BP 271 EP 280 PG 10 WC Optics; Physics, Applied SC Optics; Physics GA BG08Q UT WOS:A1996BG08Q00033 ER PT B AU Korhonen, CJ Cortez, ER Thomas, RD AF Korhonen, CJ Cortez, ER Thomas, RD BE Carlson, RF TI Minimum thermal protection for cold weather masonry SO COLD REGIONS ENGINEERING: THE COLD REGIONS INFRASTRUCTURE: AN INTERNATIONAL IMPERATIVE FOR THE 21ST CENTURY LA English DT Proceedings Paper CT 8th International Conference on Cold Regions Engineering - The Cold Regions Infrastructure: An International Imperative for the 21st-Century CY AUG 12-16, 1996 CL UNIV ALASKA FAIRBANKS, FAIRBANKS, AK SP Amer Soc Civil Engineers, Tech Council Cold Regions Engn HO UNIV ALASKA FAIRBANKS AB A study was conducted to assess ways to minimize thermal protection requirements for cold weather masonry construction. Frost damage immunity thresholds in terms of mortar moisture content and maturity were determined. Correlations of moisture content of moisture content with time were developed for mortar in contact with masonry units. Guidance for when fresh mortar can be allowed to freeze, how quickly water can be withdrawn from fresh mortar by masonry units, and at what water content mortar first become immune to frost damage are provided. The effects of temperature and antifreeze admixtures on the strength and durability of mortar were studied. RP Korhonen, CJ (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CIVIL ENGINEERS PI NEW YORK PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 BN 0-7844-0190-X PY 1996 BP 128 EP 140 PG 13 WC Engineering, Environmental; Engineering, Civil; Water Resources SC Engineering; Water Resources GA BG81P UT WOS:A1996BG81P00012 ER PT B AU Henry, KS Ellis, E AF Henry, KS Ellis, E BE Carlson, RF TI Research program for reducing frost heave with geosynthetic capillary barriers SO COLD REGIONS ENGINEERING: THE COLD REGIONS INFRASTRUCTURE: AN INTERNATIONAL IMPERATIVE FOR THE 21ST CENTURY LA English DT Proceedings Paper CT 8th International Conference on Cold Regions Engineering - The Cold Regions Infrastructure: An International Imperative for the 21st-Century CY AUG 12-16, 1996 CL UNIV ALASKA FAIRBANKS, FAIRBANKS, AK SP Amer Soc Civil Engineers, Tech Council Cold Regions Engn HO UNIV ALASKA FAIRBANKS AB A research project co-sponsored bi the U.S. Army Col pi, of Engineers, the Alaska Science and Technology Foundation, and the Alaska Department of Transportation and Public Facilities to develop design criteria Tor geosynthetic capillary barriers is being conducted at the U.S. Army Cold Regions Research and Engineering Laboratory. The successful use of geosynthetic capillary barriers would allow the Use of a greater volume of frost-susceptible soil in roadway and airport embankments, while achieving the same or better pavement performance, resulting in great cost savings. The results of past work with granular capillary barriers in pavements to reduce frost heave provide preliminary guidance for using geosynthetic capillary barriers. This paper describes the experimental program tu help define conditions under which geosynthetic capillary barriers will be effective. The primary variables being examined are geotextile pore size distribution and thickness. as well as rate of heat loss during freezing of soils. The response being measured is rate of frost heave. The selection process for candidate materials includes capillary rise testing and the application of geotextile filtration criteria. RP Henry, KS (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 0 TC 0 Z9 1 U1 0 U2 0 PU AMER SOC CIVIL ENGINEERS PI NEW YORK PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 BN 0-7844-0190-X PY 1996 BP 266 EP 277 PG 12 WC Engineering, Environmental; Engineering, Civil; Water Resources SC Engineering; Water Resources GA BG81P UT WOS:A1996BG81P00023 ER PT B AU Perkins, RA AF Perkins, RA BE Carlson, RF TI Risk assessment of vapors in cold regions SO COLD REGIONS ENGINEERING: THE COLD REGIONS INFRASTRUCTURE: AN INTERNATIONAL IMPERATIVE FOR THE 21ST CENTURY LA English DT Proceedings Paper CT 8th International Conference on Cold Regions Engineering - The Cold Regions Infrastructure: An International Imperative for the 21st-Century CY AUG 12-16, 1996 CL UNIV ALASKA FAIRBANKS, FAIRBANKS, AK SP Amer Soc Civil Engineers, Tech Council Cold Regions Engn HO UNIV ALASKA FAIRBANKS AB The effects of cold environmental temperatures on the toxicity of inhaled vapors is explored by means of a literature search in order to determine what physiological parameters may be different in cold regions, followed by input of those physiological parameters into a physiologically-based pharmacokinetic model (PBPK) for vapor inhalation. The literature search provided sufficient quantitative information for estimates regarding increased ventilation rate and blood flow distribution during two types of cold temperature metabolic compensation, shivering and non-shivering thermogenesis. That information was input into a PBPK model for styrene, ether, ethanol, and methanol. The model indicated that the hydrophobic ether yields little increase in total systemic exposure at the higher ventilation rate. Styrene, ethanol and methanol had increased systemic exposure but the increase was not linear because of altered blood flow to the liver. In general, more vapors are absorbed in cold climates than in temperate climates. Qualitative data recovered from the literature indicated that liver function is disrupted in the cold, including shifts in enzymes and decreases in anti-oxidants. Oxygen free radical production is increased, with concomitant increases in lipid peroxidation. The conclusion is that vapors may be more toxic in colder than warmer climates, but the quantitative data for risk assessment is lacking. RP Perkins, RA (reprint author), USA,CORPS ENGINEERS,FAIRBANKS RESIDENT OFF,POB 35066,FT WAINWRIGHT,AK 99703, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CIVIL ENGINEERS PI NEW YORK PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 BN 0-7844-0190-X PY 1996 BP 360 EP 371 PG 12 WC Engineering, Environmental; Engineering, Civil; Water Resources SC Engineering; Water Resources GA BG81P UT WOS:A1996BG81P00031 ER PT B AU Tobiasson, W Buska, J Greatorex, A AF Tobiasson, W Buska, J Greatorex, A BE Carlson, RF TI Snow guards for metal roofs SO COLD REGIONS ENGINEERING: THE COLD REGIONS INFRASTRUCTURE: AN INTERNATIONAL IMPERATIVE FOR THE 21ST CENTURY LA English DT Proceedings Paper CT 8th International Conference on Cold Regions Engineering - The Cold Regions Infrastructure: An International Imperative for the 21st-Century CY AUG 12-16, 1996 CL UNIV ALASKA FAIRBANKS, FAIRBANKS, AK SP Amer Soc Civil Engineers, Tech Council Cold Regions Engn HO UNIV ALASKA FAIRBANKS AB Sliding snow and ice can damage property, kill people and overload lower roofs. In valleys, moving snow can roll the standing seams onto their side, violating the waterproofing seals within them. Snow guards are used to hold snow on roofs. Some an attached mechanically while others an adhered to the metal roofing. One oi the more successful adhesives requires weeks of above-freezing weather io cure properly and thus cannot be installed successfully during the colder portion of the year. Normal ''hardware store'' silicone adhesive we tried did not last long. Special, expensive, ''neutral curing'' silicone was moderately successful as a snow guard adhesive. Plastic and aluminum angle snow guards with a peel-and-stick butyl tape did not survive even one mild winter. Set screws are used to attach several commercially available snow guards to the standing seams of metal roofing. They lit some seams well, others, poorly. Self-tapping and self-drilling screws have been used with some success when installed with care. Stainless steel structural blind rivets performed well for us for two winters, but pulled out the third winter when heavier snow loads were present on the roofs. Some damage to snow guards appears to be caused by workers using them for support when moving about on the roof. Improved design guidelines, standards and performance criteria are needed for snow guards on metal roofs. RP Tobiasson, W (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CIVIL ENGINEERS PI NEW YORK PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 BN 0-7844-0190-X PY 1996 BP 398 EP 409 PG 12 WC Engineering, Environmental; Engineering, Civil; Water Resources SC Engineering; Water Resources GA BG81P UT WOS:A1996BG81P00034 ER PT B AU Hopkins, MA Daly, SF Lever, JH AF Hopkins, MA Daly, SF Lever, JH BE Carlson, RF TI Three-dimensional simulation of river ice jams SO COLD REGIONS ENGINEERING: THE COLD REGIONS INFRASTRUCTURE: AN INTERNATIONAL IMPERATIVE FOR THE 21ST CENTURY LA English DT Proceedings Paper CT 8th International Conference on Cold Regions Engineering - The Cold Regions Infrastructure: An International Imperative for the 21st-Century CY AUG 12-16, 1996 CL UNIV ALASKA FAIRBANKS, FAIRBANKS, AK SP Amer Soc Civil Engineers, Tech Council Cold Regions Engn HO UNIV ALASKA FAIRBANKS AB A three-dimensional discrete element model coupled with a one-dimensional depth-averaged usteady hydraulic model is used to simulate river ice jam formation. Ice runs are arrested by an ice control structure consisting of cylinders spaced across a channel. This type of structure is typically constructed in small, relatively steep rivers to cause temporary ice jams in areas where flooding is not a problem, to protect downstream areas where recurrent flooding is a serious problem. The three-dimensional discrete element simulation consists of several thousand floes. Each floe is a flat circular disk with arbitrary diameter and thickness. Feedback between ice floes and water is through water drag on floes and partial blockage of the channel by floes. The simulations begin by releasing a large concentration of ice floes upstream of the structure at the flow velocity. As the ice floes move downstream, collisions between neighboring floes and collisions between floes and the channel bottom and ice control structure are explicitly modeled. Am ice jam is initiated by arching of floes between the control structures. The momentum of colliding floes and water drag cause the jam to thicken. The arrival of additional ice causes the jam to progress upstream. Concurrently,the ice forces on the structure are determined. RP Hopkins, MA (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC CIVIL ENGINEERS PI NEW YORK PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 BN 0-7844-0190-X PY 1996 BP 582 EP 593 PG 12 WC Engineering, Environmental; Engineering, Civil; Water Resources SC Engineering; Water Resources GA BG81P UT WOS:A1996BG81P00049 ER PT B AU Lever, JH Gooch, G Tuthill, A AF Lever, JH Gooch, G Tuthill, A BE Carlson, RF TI A new, low-cost ice control structure .1. Concept development SO COLD REGIONS ENGINEERING: THE COLD REGIONS INFRASTRUCTURE: AN INTERNATIONAL IMPERATIVE FOR THE 21ST CENTURY LA English DT Proceedings Paper CT 8th International Conference on Cold Regions Engineering - The Cold Regions Infrastructure: An International Imperative for the 21st-Century CY AUG 12-16, 1996 CL UNIV ALASKA FAIRBANKS, FAIRBANKS, AK SP Amer Soc Civil Engineers, Tech Council Cold Regions Engn HO UNIV ALASKA FAIRBANKS AB Communities located on small, northern rivers can experience severe breakup ice jams. While flood damages may be significant locally, they are often too low to justify conventional flood-control structures. Environmental concerns also tend to render these structures unattractive. We have developed a new, low-cost structure to control breakup ice jams on small rivers. It consists of massive sloped blocks, partially buried in riprap, placed across the river adjacent to a natural floodplain. The blocks will arrest a breakup ice run and form a stable, partially grounded ice jam. Trees or boulders on the floodplain retain ice pieces in the river channel while allowing flow to bypass the structure. Large gaps between blocks allow easy fish and canoe passage. Part 1 of this paper describes the development of this concept, and Part 2 describes its full-scale performance. RP Lever, JH (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CIVIL ENGINEERS PI NEW YORK PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 BN 0-7844-0190-X PY 1996 BP 617 EP 628 PG 12 WC Engineering, Environmental; Engineering, Civil; Water Resources SC Engineering; Water Resources GA BG81P UT WOS:A1996BG81P00052 ER PT B AU Lever, JH Gooch, G Clark, C AF Lever, JH Gooch, G Clark, C BE Carlson, RF TI A new, low-cost ice control structure .2. Construction and performance SO COLD REGIONS ENGINEERING: THE COLD REGIONS INFRASTRUCTURE: AN INTERNATIONAL IMPERATIVE FOR THE 21ST CENTURY LA English DT Proceedings Paper CT 8th International Conference on Cold Regions Engineering - The Cold Regions Infrastructure: An International Imperative for the 21st-Century CY AUG 12-16, 1996 CL UNIV ALASKA FAIRBANKS, FAIRBANKS, AK SP Amer Soc Civil Engineers, Tech Council Cold Regions Engn HO UNIV ALASKA FAIRBANKS AB Hardwick, Vermont, on the Lamoille River, has experienced 10 ice-jam floods in the past 30 years, yet damages are insufficient to justify conventional flood-control measures. We constructed a new ice-control structure (IGS) in Hardwick, in partnership with the Town and the Federal Emergency Management Agency, to assess its potential to control breakup ice jams. It consists of four massive, slope-faced granite blocks, spaced across a 27-m-wide river section adjacent to a treed floodplain, and cost $100,000, exclusive of land and design costs. We instrumented the site with pressure transducers and a video camera to record the performance of the new structure. The ICS experienced two mild breakup events during its first year of operation and held an ice jam for several hours during the more severe one. No flooding occurred downstream during these events. The field performance of the structure was similar to hydraulic model results for cases of thin, weak ice. RP Lever, JH (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CIVIL ENGINEERS PI NEW YORK PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 BN 0-7844-0190-X PY 1996 BP 629 EP 639 PG 11 WC Engineering, Environmental; Engineering, Civil; Water Resources SC Engineering; Water Resources GA BG81P UT WOS:A1996BG81P00053 ER PT B AU Kestler, MA AF Kestler, MA BE Carlson, RF TI An Open Graded Base to reduce thaw weakening in flexible pavements SO COLD REGIONS ENGINEERING: THE COLD REGIONS INFRASTRUCTURE: AN INTERNATIONAL IMPERATIVE FOR THE 21ST CENTURY LA English DT Proceedings Paper CT 8th International Conference on Cold Regions Engineering - The Cold Regions Infrastructure: An International Imperative for the 21st-Century CY AUG 12-16, 1996 CL UNIV ALASKA FAIRBANKS, FAIRBANKS, AK SP Amer Soc Civil Engineers, Tech Council Cold Regions Engn HO UNIV ALASKA FAIRBANKS AB Open Graded Bases (OGB) and Rapid Draining Material (RDM) to promote horizontal drainage of water from pavement systems have not been used extensively in the United States until recently. Drainage layers are now required beneath most Army and Air Force pavements, whether rigid or flexible. To assess the effectiveness of an OGB within a flexible pavement in areas of seasonal freezing and to ultimately evaluate the optimum OGB location within a pavement structure, three test sections with an OGB layer at different depths within the pavement structure were constructed on a USDA Forest Service Road in Berlin, NH. The sections were monitored for surface and subsurface temperature, moisture content, frost brave, pavement stiffness, and meltwater (water introduced by freeze-thaw cycles) collected in the drainage layer. Compilation of field data from these sections constitutes the First in a series of steps to determine the optimum location within a pavement system (in areas of seasonal frost) for OGB placement. This paper discusses drainage test section design, construction, instrumentation, observations to date, and overall strategy for determining the optimal OGB location. RP Kestler, MA (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CIVIL ENGINEERS PI NEW YORK PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 BN 0-7844-0190-X PY 1996 BP 878 EP 889 PG 12 WC Engineering, Environmental; Engineering, Civil; Water Resources SC Engineering; Water Resources GA BG81P UT WOS:A1996BG81P00074 ER PT J AU Duffy, DG AF Duffy, DG TI On the generation of internal waves beneath sea ice by a moving load SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article ID FLOATING ICE; PLATE AB In this paper we analyze the internal waves generated in a two-layer model of an ice-covered polar ocean or lake by a moving, steady or vibrating load. For a sufficiently slow speed, the steady load produces waves on the interface that are trapped near the load; above a critical speed these interfacial waves are larger ahead of the load than behind it. For a vibrating load surface and interfacial waves always exist and no waves are trapped. A load that moves very slowly and vibrates with a long period may resonantly excite internal waves. Although atmospheric boundary layer winds may excite waves in sea ice, the resulting internal waves are too small to be an important mechanism in the generation of observed internal waves in polar oceans. RP Duffy, DG (reprint author), US MIL ACAD,DEPT MATH SCI,W POINT,NY 10996, USA. NR 17 TC 4 Z9 5 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD JAN PY 1996 VL 24 IS 1 BP 29 EP 39 DI 10.1016/0165-232X(95)00008-Y PG 11 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA TY161 UT WOS:A1996TY16100003 ER PT J AU Hopkins, MA AF Hopkins, MA TI The effects of individual ridging events on the ice thickness distribution in the Arctic ice pack SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article ID SEA AB The sea ice thickness distribution in the polar oceans evolves in response to both dynamic and thermodynamic forcing. The variable thickness of the ice cover is created by deformation, that simultaneously causes formation of thick ice through ridge building and thin ice through lead creation The functional relationship between the redistribution of ice thicknesses and deformation is an important component in basin scale models of the Arctic ice pack. A description of the way in which ice thickens in a single pressure ridge is basic to an understanding of the redistribution over a large area of the pack containing many ridges. In this work the pressure ridging process is modeled using a two-dimensional particle simulation technique. Blocks are broken from an intact sheet of relatively thin lead ice driven against a thick, multi-year flee at a constant speed. The blocks of ice rubble accumulate to form the ridge sail and keel. A series of numerical experiments are performed with the model to determine the change in the ice thickness distribution in an area encompassing the ridge as a function of the volume of ridged lead ice. RP Hopkins, MA (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 4 TC 8 Z9 9 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD JAN PY 1996 VL 24 IS 1 BP 75 EP 82 DI 10.1016/0165-232X(95)00006-W PG 8 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA TY161 UT WOS:A1996TY16100006 ER PT J AU Brookes, PJ AF Brookes, PJ BE VanKollenburg, SE TI Keeping the self-study on track SO COLLECTION OF PAPERS ON SELF-STUDY AND INSTITUTIONAL IMPROVEMENT 1996 LA English DT Proceedings Paper CT 101st Annual Meeting of the North-Central-Association-of-Colleges-and-Schools - A Collection of Papers on Self-Study and Institutional Improvement CY MAR 23-26, 1996 CL CHICAGO, IL SP N Cent Assoc Coll & Sch, Commiss Inst Higher Educ C1 USA,COMMAND & GEN STAFF COLL,FT LEAVENWORTH,KS. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NORTH CENTRAL ASSOC COLL & SCHCOMMISSION INST HIGHER EDUC PI CHICAGO PA 30 N LASALLE ST SUITE 2400, CHICAGO, IL 60602 PY 1996 BP 221 EP 224 PG 4 WC Education & Educational Research SC Education & Educational Research GA BH91Q UT WOS:A1996BH91Q00046 ER PT J AU Kuppurao, S Tantra, I Derby, JJ AF Kuppurao, S Tantra, I Derby, JJ TI Parallel computation of radiation view factors between two arbitrarily oriented surfaces SO COMMUNICATIONS IN NUMERICAL METHODS IN ENGINEERING LA English DT Article DE view factor; radiation; parallel computation; heat transfer ID CONNECTION MACHINE; ELEMENT AB Two implementations for parallel computation of radiation heat transfer view factors are formulated and tested for a model problem. Using a sufficiently large number of processors and a suitable communications paradigm, the solution time for the problem considered here scales linearly with the number of surface elements in the parallel implementation rather than the quadratic scaling obtained using a serial approach. For larger problems, significantly shorter solution times are obtained using the massively parallel Connection Machine 5 than those obtained on a single processor of the Gray C-90, a traditional vector supercomputer. Parallel performance was degraded for implementations using too few processors or data layouts leading to inefficient processor communication. C1 UNIV MINNESOTA,ARMY HPC RES CTR,MINNEAPOLIS,MN 55455. RP Kuppurao, S (reprint author), UNIV MINNESOTA,DEPT CHEM ENGN & MAT SCI,151 AMUNSON HALL,MINNEAPOLIS,MN 55455, USA. RI Derby, Jeffrey/B-9706-2009; OI Derby, Jeffrey/0000-0001-6418-2155 NR 19 TC 1 Z9 1 U1 0 U2 1 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 1069-8299 J9 COMMUN NUMER METH EN JI Commun. Numer. Methods Eng. PD JAN PY 1996 VL 12 IS 1 BP 43 EP 50 PG 8 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Mathematics GA TV041 UT WOS:A1996TV04100005 ER PT J AU Dutta, PK Hui, D AF Dutta, PK Hui, D TI Low-temperature and freeze-thaw durability of thick composites SO COMPOSITES PART B-ENGINEERING LA English DT Article; Proceedings Paper CT 2nd International Conference for Composites Engineering CY AUG 21-24, 1995 CL NEW ORLEANS, LA DE composites; polymer-composites; fiber-reinforced-plastics; low-temperature; freeze-thaw; thermal-cycling; durability; cold-regions AB Low temperature produces internal stresses in composites of polymeric materials. The polymeric matrix phase becomes stiffer, and may suffer from damage-inducing stresses resulting from thermal coefficient mismatch of fibers and resins. These influences have been studied by subjecting two types of FRP composites to flexural tests. A commercially procured fiber reinforced plastic (FRP) composite indeed produced cracks on prolonged thermal cycling between 50 degrees C (122 degrees F) and -60 degrees C (-76 degrees F) temperature. But a specially manufactured woven glass reinforced FRP did not produce any visual cracks for two and half times more thermal cycling in the same temperature range. It is suspected that the resin type and the curing process control the thermal cycle response and ultimate durability of such FRP composites in extreme temperature environments. C1 UNIV NEW ORLEANS,DEPT ENGN MECH,NEW ORLEANS,LA 70148. RP Dutta, PK (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 25 TC 45 Z9 47 U1 1 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 1359-8368 J9 COMPOS PART B-ENG JI Compos. Pt. B-Eng. PY 1996 VL 27 IS 3-4 BP 371 EP 379 DI 10.1016/1359-8368(96)00007-8 PG 9 WC Engineering, Multidisciplinary; Materials Science, Composites SC Engineering; Materials Science GA UQ499 UT WOS:A1996UQ49900019 ER PT S AU Shen, H Dutta, M AF Shen, H Dutta, M BE Shul, RJ Pearton, SJ Ren, F Wu, CS TI Band-structure: Engineering in novel optoelectronic devices SO COMPOUND SEMICONDUCTOR ELECTRONICS AND PHOTONICS SE MATERIALS RESEARCH SOCIETY SYMPOSIUM PROCEEDINGS LA English DT Proceedings Paper CT Symposium on Compound Semiconductor Electronics and Photonics CY APR 08-10, 1996 CL SAN FRANCISCO, CA SP USA, Res Off, Bell Labs, Lucent Technol, Sandia Natl Labs, Texas Instruments C1 USA,RES LAB,PHYS SCI DIRECTORATE,PB,PS,AMSRL,FT MONMOUTH,NJ 07703. NR 0 TC 1 Z9 1 U1 0 U2 0 PU MATERIALS RESEARCH SOC PI PITTSBURGH PA 9800 MCKNIGHT RD, SUITE 327, PITTSBURGH, PA 15237 SN 0272-9172 BN 1-55899-324-X J9 MATER RES SOC SYMP P PY 1996 VL 421 BP 125 EP 131 PG 7 WC Materials Science, Multidisciplinary SC Materials Science GA BG51U UT WOS:A1996BG51U00016 ER PT S AU Flemish, JR Xie, K McLane, GF AF Flemish, JR Xie, K McLane, GF BE Shul, RJ Pearton, SJ Ren, F Wu, CS TI Dry etching of SiC for advanced device applications SO COMPOUND SEMICONDUCTOR ELECTRONICS AND PHOTONICS SE MATERIALS RESEARCH SOCIETY SYMPOSIUM PROCEEDINGS LA English DT Proceedings Paper CT Symposium on Compound Semiconductor Electronics and Photonics CY APR 08-10, 1996 CL SAN FRANCISCO, CA SP USA, Res Off, Bell Labs, Lucent Technol, Sandia Natl Labs, Texas Instruments C1 USA,RES LAB,PHYS SCI DIRECTORATE,FT MONMOUTH,NJ 07703. NR 0 TC 15 Z9 15 U1 0 U2 3 PU MATERIALS RESEARCH SOC PI PITTSBURGH PA 9800 MCKNIGHT RD, SUITE 327, PITTSBURGH, PA 15237 SN 0272-9172 BN 1-55899-324-X J9 MATER RES SOC SYMP P PY 1996 VL 421 BP 153 EP 164 PG 12 WC Materials Science, Multidisciplinary SC Materials Science GA BG51U UT WOS:A1996BG51U00020 ER PT S AU Erdogan, MU Sankaran, V Kim, KW Stroscio, MA Iafrate, GJ AF Erdogan, MU Sankaran, V Kim, KW Stroscio, MA Iafrate, GJ BE Woo, JC Park, YS TI Electric field induced type-I to type-II switching in GaAs/AlAs quantum wells SO COMPOUND SEMICONDUCTORS 1995 SE INSTITUTE OF PHYSICS CONFERENCE SERIES LA English DT Article; Proceedings Paper CT 22nd International Symposium on Compound Semiconductors - Technologies for Future Electronics and Optoelectronics Industries (ISCS-22) CY AUG 28-SEP 02, 1995 CL CHEJU ISLAND, SOUTH KOREA SP LG Electr Res Ctr, LG Semicon Co Ltd, Samsung Electr, Hyundai Electr Ind Co, Kukje Corp, Electr Div, Sammi Technol & Ind Co Ltd, Korean Air, Korea Res Fdn, Minist Educ, Korea, Minist Sci & Technol, Korea ID SUPERLATTICES AB A theoretical study of the optical properties of GaAs/AlAs quantum well structures in the presence of an electric field is presented near the type-I to type-II transition point. The band structure is calculated using a second nearest neighbor empirical sp(3) tight binding method. Intersubband transition energies and absorption coefficient are given as a function of the electric field. It is shown that the optical properties of these structures can be significantly modified with field near this point. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP Erdogan, MU (reprint author), N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695, USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU IOP PUBLISHING LTD PI BRISTOL PA TECHNO HOUSE, REDCLIFFE WAY, BRISTOL, ENGLAND BS1 6NX SN 0951-3248 BN 0-7503-0342-5 J9 INST PHYS CONF SER PY 1996 VL 145 BP 1199 EP 1202 PG 4 WC Physics, Multidisciplinary; Physics, Condensed Matter SC Physics GA BF51P UT WOS:A1996BF51P00220 ER PT B AU Tracy, FT Carrillo, A AF Tracy, FT Carrillo, A BE Aldama, AA Aparicio, J Brebbia, CA Gray, WG Herrera, I Pinder, GF TI A description of improvement in running time strategies for a three-dimensional finite element seepage/groundwater model using high performance computing (HPC) systems SO COMPUTATIONAL METHODS IN WATER RESOURCES XI, VOL 1: COMPUTATIONAL METHODS IN SUBSURFACE FLOW AND TRANSPORT PROBLEMS LA English DT Proceedings Paper CT 11th International Conference on Computational Methods in Water Resources (CMWR 96) CY JUL, 1996 CL CANCUN, MEXICO SP Mexican Inst Water Technol, Natl Autonomous Univ Mexico, Mexican Assoc Hydraul DE groundwater modeling; finite element method; high performance computing C1 USA,ENGINEER WATERWAYS EXPT STN,VICKSBURG,MS 39180. NR 0 TC 0 Z9 0 U1 0 U2 0 PU COMPUTATIONAL MECHANICS PUBLICATIONS LTD PI SOUTHAMPTON PA ASHURST LODGE, SOUTHAMPTON, HANTS, ENGLAND S04 2AA BN 1-85312-477-X PY 1996 BP 525 EP 532 PG 8 WC Mathematics, Applied; Water Resources SC Mathematics; Water Resources GA BG41G UT WOS:A1996BG41G00059 ER PT J AU Gabr, MA Wolff, TF Brizendine, AL Taylor, HM AF Gabr, MA Wolff, TF Brizendine, AL Taylor, HM TI Underseepage analysis of levees on two-layer and three-layer foundation SO COMPUTERS AND GEOTECHNICS LA English DT Article AB A simplified numerical model for the analysis of levee underseepage is developed and presented. Idealization of the subsurface hydrogeologic conditions was achieved using two-layer and three-layer representation of the pow domain. Data from Magnolia levee, located in Magnolia, Ohio, were used to demonstrate the model applicability by comparing exit hydraulic gradient (i) values fi om the simplified model to predictions from 2-D finite element analysis (FEA). Results from the simplified model indicated that i values were merely dependent on the ratio of the foundation permeability (K-fx) to the blanket permeability (K-by) The i values from the FEA closely matched those from the simplified model for K-fx/K-by ratios less than 2000 and assuming permeability anisotropic ratio (rk) = 1. Piezometer data from the S-ny Island levee, located in Quincy, Illinois, were used to demonstrate the applicability of the three-layer model. C1 MICHIGAN STATE UNIV,DEPT CIVIL ENGN,E LANSING,MI 48824. FAIRMONT STATE UNIV,DEPT CIVIL ENGN,FAIRMONT,WV 26554. WATERWAYS EXPT STN,GEOTECH LAB,VICKSBURG,MS. RP Gabr, MA (reprint author), W VIRGINIA UNIV,DEPT CIVIL ENGN,MORGANTOWN,WV 26505, USA. OI Gabr, Mohammed/0000-0001-6396-9730 NR 12 TC 4 Z9 4 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0266-352X J9 COMPUT GEOTECH JI Comput. Geotech. PY 1996 VL 18 IS 2 BP 85 EP 107 DI 10.1016/0266-352X(95)00024-5 PG 23 WC Computer Science, Interdisciplinary Applications; Engineering, Geological; Geosciences, Multidisciplinary SC Computer Science; Engineering; Geology GA TY836 UT WOS:A1996TY83600001 ER PT B AU Hicks, DK Kirby, JG East, EW AF Hicks, DK Kirby, JG East, EW BE Vanegas, J Chinowsky, P TI Towards lessons-learned systems in the US army, Corps of Engineers SO COMPUTING IN CIVIL ENGINEERING LA English DT Proceedings Paper CT 3rd Congress on Computing in Civil Engineering (III-CCCE) CY JUN 17-19, 1996 CL ANAHEIM, CA SP ASCE, Tech Council Comp Practices C1 USA,CONSTRUCT ENGN RES LABS,CHAMPAIGN,IL 61826. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CIVIL ENGINEERS PI NEW YORK PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 BN 0-7844-0182-9 PY 1996 BP 112 EP 117 PG 6 WC Computer Science, Interdisciplinary Applications; Engineering, Civil SC Computer Science; Engineering GA BG42N UT WOS:A1996BG42N00017 ER PT B AU Subick, C Adiguzel, I AF Subick, C Adiguzel, I BE Vanegas, J Chinowsky, P TI Integrated infrastructure maintenance management SO COMPUTING IN CIVIL ENGINEERING LA English DT Proceedings Paper CT 3rd Congress on Computing in Civil Engineering (III-CCCE) CY JUN 17-19, 1996 CL ANAHEIM, CA SP ASCE, Tech Council Comp Practices C1 USA,CONSTRUCT ENGN RES LABS,CHAMPAIGN,IL 61826. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CIVIL ENGINEERS PI NEW YORK PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 BN 0-7844-0182-9 PY 1996 BP 207 EP 213 PG 7 WC Computer Science, Interdisciplinary Applications; Engineering, Civil SC Computer Science; Engineering GA BG42N UT WOS:A1996BG42N00031 ER PT B AU Goettel, BC AF Goettel, BC BE Vanegas, J Chinowsky, P TI Implementing the Knowledge Worker System (KWS) in an engineering environment SO COMPUTING IN CIVIL ENGINEERING LA English DT Proceedings Paper CT 3rd Congress on Computing in Civil Engineering (III-CCCE) CY JUN 17-19, 1996 CL ANAHEIM, CA SP ASCE, Tech Council Comp Practices C1 USA,CONSTRUCT ENGN RES LABS,CHAMPAIGN,IL 61826. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CIVIL ENGINEERS PI NEW YORK PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 BN 0-7844-0182-9 PY 1996 BP 288 EP 293 PG 6 WC Computer Science, Interdisciplinary Applications; Engineering, Civil SC Computer Science; Engineering GA BG42N UT WOS:A1996BG42N00043 ER PT B AU ONeill, RJ Henry, RM Lenox, TA AF ONeill, RJ Henry, RM Lenox, TA BE Vanegas, J Chinowsky, P TI Role of computing: Practitioners' perspective SO COMPUTING IN CIVIL ENGINEERING LA English DT Proceedings Paper CT 3rd Congress on Computing in Civil Engineering (III-CCCE) CY JUN 17-19, 1996 CL ANAHEIM, CA SP ASCE, Tech Council Comp Practices C1 US MIL ACAD,DEPT CIVIL ENGN & MECH,CIVIL ENGN DIV,W POINT,NY 10996. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC CIVIL ENGINEERS PI NEW YORK PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 BN 0-7844-0182-9 PY 1996 BP 670 EP 676 PG 7 WC Computer Science, Interdisciplinary Applications; Engineering, Civil SC Computer Science; Engineering GA BG42N UT WOS:A1996BG42N00098 ER PT B AU Leenknecht, DA Tanner, WW AF Leenknecht, DA Tanner, WW BE Vanegas, J Chinowsky, P TI Scientific visualization techniques for wave transformation models SO COMPUTING IN CIVIL ENGINEERING LA English DT Proceedings Paper CT 3rd Congress on Computing in Civil Engineering (III-CCCE) CY JUN 17-19, 1996 CL ANAHEIM, CA SP ASCE, Tech Council Comp Practices C1 USA,ENGINEER WATERWAYS EXPT STN,COASTAL ENGN RES CTR,VICKSBURG,MS 39180. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CIVIL ENGINEERS PI NEW YORK PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 BN 0-7844-0182-9 PY 1996 BP 704 EP 710 PG 7 WC Computer Science, Interdisciplinary Applications; Engineering, Civil SC Computer Science; Engineering GA BG42N UT WOS:A1996BG42N00103 ER PT B AU Brucker, BA Stumpf, AL AF Brucker, BA Stumpf, AL BE Vanegas, J Chinowsky, P TI Design information evolution in a collaborative engineering software environment SO COMPUTING IN CIVIL ENGINEERING LA English DT Proceedings Paper CT 3rd Congress on Computing in Civil Engineering (III-CCCE) CY JUN 17-19, 1996 CL ANAHEIM, CA SP ASCE, Tech Council Comp Practices C1 USA,CERL,ENGN PROC DIV,CHAMPAIGN,IL 61821. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CIVIL ENGINEERS PI NEW YORK PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 BN 0-7844-0182-9 PY 1996 BP 732 EP 738 PG 7 WC Computer Science, Interdisciplinary Applications; Engineering, Civil SC Computer Science; Engineering GA BG42N UT WOS:A1996BG42N00107 ER PT B AU McGraw, KD Lawrence, PW Morton, JD Heckel, J AF McGraw, KD Lawrence, PW Morton, JD Heckel, J BE Vanegas, J Chinowsky, P TI The agent collaboration environment, an assistant for architects and engineers SO COMPUTING IN CIVIL ENGINEERING LA English DT Proceedings Paper CT 3rd Congress on Computing in Civil Engineering (III-CCCE) CY JUN 17-19, 1996 CL ANAHEIM, CA SP ASCE, Tech Council Comp Practices C1 USA,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL 61824. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CIVIL ENGINEERS PI NEW YORK PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 BN 0-7844-0182-9 PY 1996 BP 739 EP 745 PG 7 WC Computer Science, Interdisciplinary Applications; Engineering, Civil SC Computer Science; Engineering GA BG42N UT WOS:A1996BG42N00108 ER PT B AU Burke, T Xie, K Flemish, JR Singh, H Podlesak, T Zhao, JH AF Burke, T Xie, K Flemish, JR Singh, H Podlesak, T Zhao, JH GP IEEE TI Silicon carbide power devices for high temperature, high power density switching applications SO CONFERENCE RECORD OF THE 1996 TWENTY-SECOND INTERNATIONAL POWER MODULATOR SYMPOSIUM LA English DT Proceedings Paper CT 22nd International Power Modulator Symposium CY JUN 25-27, 1996 CL BOCA RATON, FL SP USA Res Lab, USA Res Off, Air Force Wright Lab, Sandia Natl Labs, Naval Surface Warfare Ctr, Adv Grp Electron Devices, IEEE Electron Devices Soc RP Burke, T (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU I E E E PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 BN 0-7803-3077-3 PY 1996 BP 18 EP 21 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA BG88Z UT WOS:A1996BG88Z00005 ER PT B AU Podlesak, TF Singh, H Behr, S Schneider, S AF Podlesak, TF Singh, H Behr, S Schneider, S GP IEEE TI A compact lightweight 125 mm thyristor for pulse power applications SO CONFERENCE RECORD OF THE 1996 TWENTY-SECOND INTERNATIONAL POWER MODULATOR SYMPOSIUM LA English DT Proceedings Paper CT 22nd International Power Modulator Symposium CY JUN 25-27, 1996 CL BOCA RATON, FL SP USA Res Lab, USA Res Off, Air Force Wright Lab, Sandia Natl Labs, Naval Surface Warfare Ctr, Adv Grp Electron Devices, IEEE Electron Devices Soc AB A compact, lightweight, symmetric 125mm diameter silicon thyristor is under development by SPCO for high current millisecond pulse power applications, i.e. electric launchers. This thyristor has a drastically reduced size and weight. This is due to a new design which eliminates the need for large, heavy refractory metal substrates and endpieces, employs an alloyed anode interface for high surge currents, and a high integrity plastic disk package. The package is less than one-fifth the volume and weight of a package utilizing standard construction technology, and provides for double sided cooling and a lower thermal resistance from junction to sink of 0.0033 K/W. Exploratory testing has been performed at ARL using a 10 milliohm, 0.5 ms (FWHM) PFN. With a matched load the pulser at 4 kV can provide peak currents of 200 kA with a di/dt in excess of I kA/us. Initial results on the temporal behavior as a function of operating levels under matched load conditions are presented. A computer simulation of the behavior of the device using the actual current pulse shape was consistent with the experimental results. The present six star gate design does not provide the rate of plasma spreading required for 200 kA operation. A computer model using an involute gate structure indicates-that the peak current objectives are achievable. The development of this switch will permit the construction of compact, lightweight high voltage series switch stacks for electric guns. RP Podlesak, TF (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU I E E E PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 BN 0-7803-3077-3 PY 1996 BP 43 EP 46 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA BG88Z UT WOS:A1996BG88Z00011 ER PT B AU Brown, P McCordic, C Steudel, M AF Brown, P McCordic, C Steudel, M GP IEEE TI A pulsed, high-power, high-voltage video load for the ALCOR transmitter SO CONFERENCE RECORD OF THE 1996 TWENTY-SECOND INTERNATIONAL POWER MODULATOR SYMPOSIUM LA English DT Proceedings Paper CT 22nd International Power Modulator Symposium CY JUN 25-27, 1996 CL BOCA RATON, FL SP USA Res Lab, USA Res Off, Air Force Wright Lab, Sandia Natl Labs, Naval Surface Warfare Ctr, Adv Grp Electron Devices, IEEE Electron Devices Soc RP Brown, P (reprint author), USA,RANGE SYST ENGN,RAYTHEON,POB 997,APO,AP 96557, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU I E E E PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 BN 0-7803-3077-3 PY 1996 BP 125 EP 128 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA BG88Z UT WOS:A1996BG88Z00031 ER PT B AU Davanloo, F Korioth, JL Borovina, DL Krause, RK Collins, CB AF Davanloo, F Korioth, JL Borovina, DL Krause, RK Collins, CB GP IEEE TI Stacked Blumlein pulse generators SO CONFERENCE RECORD OF THE 1996 TWENTY-SECOND INTERNATIONAL POWER MODULATOR SYMPOSIUM LA English DT Proceedings Paper CT 22nd International Power Modulator Symposium CY JUN 25-27, 1996 CL BOCA RATON, FL SP USA Res Lab, USA Res Off, Air Force Wright Lab, Sandia Natl Labs, Naval Surface Warfare Ctr, Adv Grp Electron Devices, IEEE Electron Devices Soc AB Extensive characterization of the stacked Blumlein pulsers has been performed over the past few years. Results indicate that, these devices are capable of producing high-power waveforms with risetimes and repetition rates in the range of 0.2 - 50 ns and 1 - 300 Hz, respectively, using a conventional thyratron, spark gap, or photoconductive switch. This paper reviews the progress made to date in the development of these novel pulsers. It is shown that, with slight design modifications, they can produce waveforms with fast risetimes and a wide range of pulse durations and peak values. An analysis of the behavior of the stacked Blumlein pulsers is given and the results of performance tests are discussed. C1 USAF,PHILLIPS LAB,WSQ,KIRTLAND AFB,NM 87117. USA,CECOM,S&TCD,FT MONMOUTH,NJ 07703. RP Davanloo, F (reprint author), UNIV TEXAS,CTR QUANTUM ELECT,POB 830688,RICHARDSON,TX 75083, USA. NR 0 TC 0 Z9 1 U1 0 U2 0 PU I E E E PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 BN 0-7803-3077-3 PY 1996 BP 181 EP 185 PG 5 WC Engineering, Electrical & Electronic SC Engineering GA BG88Z UT WOS:A1996BG88Z00045 ER PT S AU Dawson, MQ AF Dawson, MQ BE Crouch, C Eidahl, KO Horward, DD TI The impact of Napoleon Bonaparte on American opinion and policy in 1796 and 1797 SO CONSORTIUM ON REVOLUTIONARY EUROPE 1750-1850 - SELECTED PAPERS, 1996 SE CONSORTIUM ON REVOLUTIONARY EUROPE 1750-1850 : PROCEEDINGS LA English DT Proceedings Paper CT 26th Meeting of the Consortium-on-Revolutionary-Europe CY FEB 29-MAR 02, 1996 CL SAVANNAH, GA SP Consortium Revolut Europe C1 US MIL ACAD,W POINT,NY 10996. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CONSORTIUM REVOLUTIONARY EUROPE PI TALLAHASSEE PA 6611 CROOKED CREEK RD, TALLAHASSEE, FL 32311 SN 0093-2574 J9 CONSORT REVOLUT EUR PY 1996 BP 143 EP 149 PG 7 WC History SC History GA BJ15P UT WOS:A1996BJ15P00018 ER PT S AU DeToy, BM AF DeToy, BM BE Crouch, C Eidahl, KO Horward, DD TI French invasions: George Berkeley and defense, 1779-1811 SO CONSORTIUM ON REVOLUTIONARY EUROPE 1750-1850 - SELECTED PAPERS, 1996 SE CONSORTIUM ON REVOLUTIONARY EUROPE 1750-1850 : PROCEEDINGS LA English DT Proceedings Paper CT 26th Meeting of the Consortium-on-Revolutionary-Europe CY FEB 29-MAR 02, 1996 CL SAVANNAH, GA SP Consortium Revolut Europe C1 US MIL ACAD,W POINT,NY 10996. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CONSORTIUM REVOLUTIONARY EUROPE PI TALLAHASSEE PA 6611 CROOKED CREEK RD, TALLAHASSEE, FL 32311 SN 0093-2574 J9 CONSORT REVOLUT EUR PY 1996 BP 183 EP 190 PG 8 WC History SC History GA BJ15P UT WOS:A1996BJ15P00024 ER PT S AU Krajeski, PC AF Krajeski, PC BE Crouch, C Eidahl, KO Horward, DD TI The foundation of British amphibious warfare methodology during the Napoleonic era, 1793-1815 SO CONSORTIUM ON REVOLUTIONARY EUROPE 1750-1850 - SELECTED PAPERS, 1996 SE CONSORTIUM ON REVOLUTIONARY EUROPE 1750-1850 : PROCEEDINGS LA English DT Proceedings Paper CT 26th Meeting of the Consortium-on-Revolutionary-Europe CY FEB 29-MAR 02, 1996 CL SAVANNAH, GA SP Consortium Revolut Europe C1 US MIL ACAD,W POINT,NY 10996. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CONSORTIUM REVOLUTIONARY EUROPE PI TALLAHASSEE PA 6611 CROOKED CREEK RD, TALLAHASSEE, FL 32311 SN 0093-2574 J9 CONSORT REVOLUT EUR PY 1996 BP 191 EP 198 PG 8 WC History SC History GA BJ15P UT WOS:A1996BJ15P00025 ER PT S AU Cornell, T AF Cornell, T BE Crouch, C Eidahl, KO Horward, DD TI The military revolution, effectiveness, innovation, and the Duke of Wellington SO CONSORTIUM ON REVOLUTIONARY EUROPE 1750-1850 - SELECTED PAPERS, 1996 SE CONSORTIUM ON REVOLUTIONARY EUROPE 1750-1850 : PROCEEDINGS LA English DT Proceedings Paper CT 26th Meeting of the Consortium-on-Revolutionary-Europe CY FEB 29-MAR 02, 1996 CL SAVANNAH, GA SP Consortium Revolut Europe C1 US MIL ACAD,W POINT,NY. NR 0 TC 1 Z9 1 U1 0 U2 0 PU CONSORTIUM REVOLUTIONARY EUROPE PI TALLAHASSEE PA 6611 CROOKED CREEK RD, TALLAHASSEE, FL 32311 SN 0093-2574 J9 CONSORT REVOLUT EUR PY 1996 BP 250 EP 259 PG 10 WC History SC History GA BJ15P UT WOS:A1996BJ15P00032 ER PT S AU Bowman, SL AF Bowman, SL BE Crouch, C Eidahl, KO Horward, DD TI Using Napoleonic staff rides to educate the modern military officer: Jena/Auerstadt SO CONSORTIUM ON REVOLUTIONARY EUROPE 1750-1850 - SELECTED PAPERS, 1996 SE CONSORTIUM ON REVOLUTIONARY EUROPE 1750-1850 : PROCEEDINGS LA English DT Proceedings Paper CT 26th Meeting of the Consortium-on-Revolutionary-Europe CY FEB 29-MAR 02, 1996 CL SAVANNAH, GA SP Consortium Revolut Europe C1 USA,MIL HIST INST,WASHINGTON,DC 20310. NR 0 TC 0 Z9 0 U1 0 U2 1 PU CONSORTIUM REVOLUTIONARY EUROPE PI TALLAHASSEE PA 6611 CROOKED CREEK RD, TALLAHASSEE, FL 32311 SN 0093-2574 J9 CONSORT REVOLUT EUR PY 1996 BP 269 EP 274 PG 6 WC History SC History GA BJ15P UT WOS:A1996BJ15P00034 ER PT J AU Epstein, RM AF Epstein, RM BE Crouch, C Eidahl, KO Horward, DD TI In defense of patrie: A commentary SO CONSORTIUM ON REVOLUTIONARY EUROPE 1750-1850 - SELECTED PAPERS, 1996 SE CONSORTIUM ON REVOLUTIONARY EUROPE 1750-1850 : PROCEEDINGS LA English DT Proceedings Paper CT 26th Meeting of the Consortium-on-Revolutionary-Europe CY FEB 29-MAR 02, 1996 CL SAVANNAH, GA SP Consortium Revolut Europe C1 SCH ADV MIL STUDIES,FT LEAVENWORTH,KS. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CONSORTIUM REVOLUTIONARY EUROPE PI TALLAHASSEE PA 6611 CROOKED CREEK RD, TALLAHASSEE, FL 32311 SN 0093-2574 J9 CONSORT REVOLUT EUR PY 1996 BP 312 EP 314 PG 3 WC History SC History GA BJ15P UT WOS:A1996BJ15P00039 ER PT B AU Adams, JW Bennett, HJH AF Adams, JW Bennett, HJH BE Calabrese, EJ Kostecki, PT Bonazountas, M TI Using reflectance Fourier transform infrared spectroscopy (FTIR) for rapid analysis of contaminated soils SO CONTAMINATED SOILS, VOL 1 LA English DT Proceedings Paper CT 10th Annual Conference on Contaminated Soils CY 1996 CL UNIV MASSACHUSETTS AMHERST, AMHERST, MA SP 3M, Assoc Environm Hlth Soils, CER Corp, Earth Tech, Environm Sci Serv, New York Dept Environm Conservat, Millipore Corp, NE Util Serv Co, Ogden Environm & Energy Serv, Remediat Technol Inc, Roy F Weston Inc, Texaco Inc, Tyree Org Ltd, United Retek Corp HO UNIV MASSACHUSETTS AMHERST RP Adams, JW (reprint author), USA,ENGINEER WATERWAYS EXPT STN,VICKSBURG,MS 39180, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMHERST SCIENTIFIC PUBLISHERS PI AMHERST PA 150 FEARING STREET, AMHERST, MA 01002 BN 1-884940-07-2 PY 1996 BP 241 EP 252 PG 12 WC Engineering, Environmental; Engineering, Chemical; Environmental Sciences; Public, Environmental & Occupational Health; Nuclear Science & Technology SC Engineering; Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Nuclear Science & Technology GA BJ54B UT WOS:A1996BJ54B00017 ER PT B AU Dette, MJ AF Dette, MJ BE Calabrese, EJ Kostecki, PT Bonazountas, M TI Army overview of environmental remediation technology SO CONTAMINATED SOILS, VOL 1 LA English DT Proceedings Paper CT 10th Annual Conference on Contaminated Soils CY 1996 CL UNIV MASSACHUSETTS AMHERST, AMHERST, MA SP 3M, Assoc Environm Hlth Soils, CER Corp, Earth Tech, Environm Sci Serv, New York Dept Environm Conservat, Millipore Corp, NE Util Serv Co, Ogden Environm & Energy Serv, Remediat Technol Inc, Roy F Weston Inc, Texaco Inc, Tyree Org Ltd, United Retek Corp HO UNIV MASSACHUSETTS AMHERST RP Dette, MJ (reprint author), USA,CTR ENVIRONM,TECHNOL DEMONSTRAT & TRANSFER BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMHERST SCIENTIFIC PUBLISHERS PI AMHERST PA 150 FEARING STREET, AMHERST, MA 01002 BN 1-884940-07-2 PY 1996 BP 275 EP 278 PG 4 WC Engineering, Environmental; Engineering, Chemical; Environmental Sciences; Public, Environmental & Occupational Health; Nuclear Science & Technology SC Engineering; Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Nuclear Science & Technology GA BJ54B UT WOS:A1996BJ54B00021 ER PT B AU Wright, TW Ravichandran, G AF Wright, TW Ravichandran, G BE Batra, RC Beatty, MF TI On shock-induced damage in ceramics SO CONTEMPORARY RESEARCH IN THE MECHANICS AND MATHEMATICS OF MATERIALS SE THEORY AND ENGINEERING APPLICATIONS OF COMPUTATIONAL METHODS: A SERIES OF HANDBOOKS LA English DT Proceedings Paper CT Symposium on Recent Developments in Elasticity CY JUN 12-15, 1996 CL JOHN HOPKINS UNIV, BALTIMORE, MD HO JOHN HOPKINS UNIV ID COMPRESSION AB Simple ideas concerning elastic shocks, linear elastic fracture mechanics, and selfsimilar elastic propagation of cracks are used to initiate a study of damage induced in ceramics or other brittle materials by the passage of compressive shock waves. C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Wright, TW (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 10 TC 2 Z9 2 U1 0 U2 1 PU INT CENTER NUMERICAL METHODS ENGINEERING PI 08034 BARCELONA PA GRAN CAPITAN, S-N, CAMPUS NORTE UPC, MODULO C1, 08034 BARCELONA, SPAIN BN 84-87867-74-X J9 THEOR ENGN APPLICAT PY 1996 BP 480 EP 488 PG 3 WC Materials Science, Multidisciplinary; Mathematics, Applied; Mechanics SC Materials Science; Mathematics; Mechanics GA BQ76M UT WOS:000089454900040 ER PT J AU McQueen, CE Hicks, CB AF McQueen, CE Hicks, CB TI Treatment of gastrointestinal infections SO CURRENT OPINION IN GASTROENTEROLOGY LA English DT Article AB This review highlights recent reports of new developments in the treatment of gastrointestinal infections. Data are emerging that indicate at least one subset of dyspeptic patients may benefit from treatment to eradicate Helicobacter pylori. Several studies of regimens used to treat H. pylori infection provide incremental improvements to classic triple therapy. Efforts made to improve the World Health Organization oral rehydration solution tend to support various substitutions for the glucose component but do not as yet demonstrate compelling superiority, Promising new approaches to the treatment of recurrent Clostridium difficile infections include the addition of yeast to standard antibiotic regimens and the binding of toxin receptors by synthetic oligosaccharide sequences. Comparisons of patient responses to different approaches for treating esophageal and intestinal superinfections in patients with HIV provide additional insight into the evaluation and management of these patients. Finally, trimethoprim-sulfamethoxazole appears to be emerging as the treatment of choice for the newly recognized parasitic pathogen Cyclospora. RP McQueen, CE (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT GASTROENTEROL,BLDG 40,WASHINGTON,DC 20307, USA. NR 55 TC 1 Z9 1 U1 0 U2 0 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0267-1379 J9 CURR OPIN GASTROEN JI Curr. Opin. Gastroenterol. PD JAN PY 1996 VL 12 IS 1 BP 54 EP 61 PG 8 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA TZ239 UT WOS:A1996TZ23900011 ER PT S AU Lanzerotti, MYD Autera, J Borne, L Sharma, J AF Lanzerotti, MYD Autera, J Borne, L Sharma, J BE Brill, TB Russell, TP Tao, WC Wardle, RB TI Crystal growth of energetic materials during high acceleration SO DECOMPOSITION, COMBUSTION, AND DETONATION CHEMISTRY OF ENERGETIC MATERIALS SE MATERIALS RESEARCH SOCIETY SYMPOSIUM PROCEEDINGS LA English DT Proceedings Paper CT Symposium on Decomposition, Combustion, and Detonation Chemistry of Energetic Materials CY NOV 27-30, 1995 CL BOSTON, MA SP Mat Res Soc C1 USA,ARDEC,PICATINNY ARSENAL,NJ 07806. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MATERIALS RESEARCH SOC PI PITTSBURGH PA 9800 MCKNIGHT RD, SUITE 327, PITTSBURGH, PA 15237 SN 0272-9172 BN 1-55899-321-5 J9 MATER RES SOC SYMP P PY 1996 VL 418 BP 73 EP 78 PG 6 WC Thermodynamics; Chemistry, Physical; Materials Science, Multidisciplinary; Materials Science, Characterization & Testing SC Thermodynamics; Chemistry; Materials Science GA BF14Y UT WOS:A1996BF14Y00010 ER PT S AU Miller, MS AF Miller, MS BE Brill, TB Russell, TP Tao, WC Wardle, RB TI Three-phase combustion modelling: Frozen ozone, a prototype system SO DECOMPOSITION, COMBUSTION, AND DETONATION CHEMISTRY OF ENERGETIC MATERIALS SE MATERIALS RESEARCH SOCIETY SYMPOSIUM PROCEEDINGS LA English DT Proceedings Paper CT Symposium on Decomposition, Combustion, and Detonation Chemistry of Energetic Materials CY NOV 27-30, 1995 CL BOSTON, MA SP Mat Res Soc C1 USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005. NR 0 TC 2 Z9 2 U1 0 U2 0 PU MATERIALS RESEARCH SOC PI PITTSBURGH PA 9800 MCKNIGHT RD, SUITE 327, PITTSBURGH, PA 15237 SN 0272-9172 BN 1-55899-321-5 J9 MATER RES SOC SYMP P PY 1996 VL 418 BP 169 EP 180 PG 12 WC Thermodynamics; Chemistry, Physical; Materials Science, Multidisciplinary; Materials Science, Characterization & Testing SC Thermodynamics; Chemistry; Materials Science GA BF14Y UT WOS:A1996BF14Y00022 ER PT J AU Anderson, LL Cardone, JS McCollough, ML Grabski, WJ AF Anderson, LL Cardone, JS McCollough, ML Grabski, WJ TI Tattoo pigment mimicking metastatic malignant melanoma SO DERMATOLOGIC SURGERY LA English DT Article AB BACKGROUND. The benefits of elective lymph node dissection (ELND) in the treatment of melanoma remain controversial, however, it may be beneficial in some patients. Tattoo pigment from decorative tattoos may migrate to the regional lymph nodes. In patients who develop malignant melanoma and who have been tattooed, this pigment may clinically mimic metastatic disease. OBJECTIVE. We wish to alert clinicians that pigment from tattoos may migrate to the regional lymph nodes. In the unusual instance of a tattooed patient who develops malignant melanoma, when undergoing ELND, surgeons should rely on histologic confirmation of metastatic disease before altering operative plans. METHODS. ELND for malignant melanoma, in a patient with a history of decorative tattoos that had been removed by dermabrasion, was performed. Black lymph nodes that clinically resembled metastatic disease were identified. Subsequent histologic examination revealed normal lymph node architecture with a heavy collection of black pigment. Mass spectrophotometry showed this pigment to be consistent with tattoo dye. RESULTS. A patient who had undergone dermabrasion for removal of decorative tattoos developed malignant melanoma in the same extremity. Clinically suspicious black lymph nodes were identified during ELND. Histologic examination did not reveal metastatic disease. Additional therapy was not considered intra- or postoperatively even though the clinical suspicion of metastatic disease was high. The patient was not subjected to any unnecessary emotional or physical distress pending histologic confirmation. CONCLUSIONS. Tattoo pigment in the lymph nodes may clinically mimic metastatic melanoma. Histologic confirmation of metastatic disease should always be obtained before additional therapy is considered. C1 DARNALL ARMY COMMUNITY HOSP,DERMATOL SERV,FT HOOD,TX. RP Anderson, LL (reprint author), BROOKE ARMY MED CTR,DERMATOL SERV,FT SAM HOUSTON,TX 78234, USA. NR 5 TC 36 Z9 36 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 1076-0512 J9 DERMATOL SURG JI Dermatol. Surg. PD JAN PY 1996 VL 22 IS 1 BP 92 EP 94 PG 3 WC Dermatology; Surgery SC Dermatology; Surgery GA TR180 UT WOS:A1996TR18000016 PM 8556264 ER PT B AU Trang, AH AF Trang, AH BE Dubey, AC Barnard, RL Lowe, CJ McFee, JE TI Simulation of mine detection over dry soil, snow, ice, and water SO DETECTION AND REMEDIATION TECHNOLOGIES FOR MINES AND MINELIKE TARGETS SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Detection and Remediation Technologies for Mines and Minelike Targets CY APR 09-12, 1996 CL ORLANDO, FL SP Soc Photo Opt Instrumentat Engineers, Inst Elect Engineers DE simulation of mine detection; mine detection in snow; pulse reflections and transmissions; mine detection C1 USA,CECOM,NIGHT VIS & ELECTR SENSOR DIRECTORATE,AMSEL RD NV CD MD,FT BELVOIR,VA 22060. NR 0 TC 4 Z9 4 U1 0 U2 0 PU SPIE - INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 BN 0-8194-2146-4 J9 P SOC PHOTO-OPT INS PY 1996 VL 2765 BP 430 EP 440 DI 10.1117/12.241246 PG 11 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA BF76U UT WOS:A1996BF76U00040 ER PT B AU Cionco, RM Byers, JH AF Cionco, RM Byers, JH BE Zannetti, P Brebbia, CA TI High resolution, near field, meteorological wind analysis system for emergency response and other applications SO DEVELOPMENT AND APPLICATION OF COMPUTER TECHNIQUES TO ENVIRONMENTAL STUDIES VI LA English DT Proceedings Paper CT 6th International Conference on Development and Application of Computer Techniques to Environmental Studies (ENVIROSOFT 96) CY SEP 18-20, 1996 CL COMO, ITALY SP Wessex Inst Technol, UK AB In most emergency response activities, it is essential to know how the local meteorological conditions and terrain can affect inadvertent and accidental releases and other operations. A better representation of the near field meteorology will ensure a more accurate and dependable on-site handling of situations of hazardous materials. This means including the presence and effects of land feature morphology (i.e. vegetation, buildings, etc) as well as terrain in your analysis. To transform meteorological models/codes into information for response and assessment during emergency activities, some seven tasks may be implemented with a high resolution, micrometeorological code in-hand. The user can then analyze areas affected as having adverse and favorable impacts at and downwind of the hazardous release site. The results of the effects analysis can be interpreted on-site for customized use and assessment information. This wind simulation and effects analysis system was used successfully during the planning stages and on-site, real-time during the conduct of the recent MADONA Field Study. The described methods can easily be adapted to a variety of other field activities where the wind is influenced by the presence and configuration of variable terrain, and building and vegetation features within the domain. RP Cionco, RM (reprint author), USA,RES LAB,S,BE,AMSRL,ATTN,WHITE SANDS MISSILE RANGE,NM 88002, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU COMPUTATIONAL MECHANICS PUBLICATIONS LTD PI SOUTHAMPTON PA ASHURST LODGE, SOUTHAMPTON, HANTS, ENGLAND S04 2AA BN 1-85312-411-7 PY 1996 BP 361 EP 370 PG 10 WC Computer Science, Interdisciplinary Applications; Engineering, Environmental; Engineering, Civil; Engineering, Mechanical; Mechanics SC Computer Science; Engineering; Mechanics GA BG78J UT WOS:A1996BG78J00035 ER PT B AU Prather, DW Mirotznik, MS Mait, JN AF Prather, DW Mirotznik, MS Mait, JN BE Cindrich, I Lee, SH TI Design of subwavelength diffractive optical elements using a hybrid finite element boundary element method SO DIFFRACTIVE AND HOLOGRAPHIC OPTICS TECHNOLOGY III SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Diffractive and Holographic Optics Technology III CY FEB 01-02, 1996 CL SAN JOSE, CA SP Soc Photo Opt Instrumentat Engineers, Adv Res Projects Agcy DE diffractive optics; DOE synthesis; vector modeling; subwavelength DOEs C1 USA,RES LAB,ADELPHI,MD 20783. NR 0 TC 5 Z9 5 U1 1 U2 1 PU SPIE - INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 BN 0-8194-2063-8 J9 P SOC PHOTO-OPT INS PY 1996 VL 2689 BP 14 EP 23 DI 10.1117/12.239612 PG 10 WC Optics SC Optics GA BF67S UT WOS:A1996BF67S00002 ER PT B AU Langford, CW AF Langford, CW BE Suresh, R TI Army initiatives in battlefield digitization a presentation for the International Society for Optical Engineering SO DIGITIZATION OF THE BATTLEFIELD SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT 1st International Symposium on Digitization of the Battlefield CY APR 10-11, 1996 CL ORLANDO, FL SP Soc Photo Opt Instrumentat Engineers C1 USA,WASHINGTON,DC 20310. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPIE - INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 BN 0-8194-2145-6 J9 P SOC PHOTO-OPT INS PY 1996 VL 2764 BP 2 EP 21 PG 20 WC Optics SC Optics GA BF76T UT WOS:A1996BF76T00001 ER PT B AU McCorkle, WC Alongi, RE VanKirk, GP AF McCorkle, WC Alongi, RE VanKirk, GP BE Suresh, R TI Teleoperated missiles as a reconnaissance asset on the digitized battlefield SO DIGITIZATION OF THE BATTLEFIELD SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT 1st International Symposium on Digitization of the Battlefield CY APR 10-11, 1996 CL ORLANDO, FL SP Soc Photo Opt Instrumentat Engineers C1 USA,MISSILE RES DEV & ENGN CTR,REDSTONE ARSENAL,AL 35898. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPIE - INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 BN 0-8194-2145-6 J9 P SOC PHOTO-OPT INS PY 1996 VL 2764 BP 22 EP 30 DI 10.1117/12.242080 PG 9 WC Optics SC Optics GA BF76T UT WOS:A1996BF76T00002 ER PT B AU Hughes, BK Fox, CS AF Hughes, BK Fox, CS BE Suresh, R TI Combat identification SO DIGITIZATION OF THE BATTLEFIELD SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT 1st International Symposium on Digitization of the Battlefield CY APR 10-11, 1996 CL ORLANDO, FL SP Soc Photo Opt Instrumentat Engineers DE identification; fratricide; awareness C1 USA,FALLS CHURCH,VA 22041. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPIE - INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 BN 0-8194-2145-6 J9 P SOC PHOTO-OPT INS PY 1996 VL 2764 BP 42 EP 50 DI 10.1117/12.242082 PG 9 WC Optics SC Optics GA BF76T UT WOS:A1996BF76T00004 ER PT B AU Yarosh, V AF Yarosh, V BE Suresh, R TI Map-based decision aids for fire support SO DIGITIZATION OF THE BATTLEFIELD SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT 1st International Symposium on Digitization of the Battlefield CY APR 10-11, 1996 CL ORLANDO, FL SP Soc Photo Opt Instrumentat Engineers DE decision aids; artificial intelligence; digital mapping; fire support; battlefield digitization C1 USA,TANK AUTOMOT & ARMAMENT COMMAND,ARMAMENT RES DEV & ENGN CTR,PICATINNY ARSENAL,NJ 07806. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPIE - INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 BN 0-8194-2145-6 J9 P SOC PHOTO-OPT INS PY 1996 VL 2764 BP 56 EP 65 DI 10.1117/12.242084 PG 10 WC Optics SC Optics GA BF76T UT WOS:A1996BF76T00006 ER PT B AU Mariani, D AF Mariani, D BE Suresh, R TI Crew station for ground combat vehicles SO DIGITIZATION OF THE BATTLEFIELD SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT 1st International Symposium on Digitization of the Battlefield CY APR 10-11, 1996 CL ORLANDO, FL SP Soc Photo Opt Instrumentat Engineers DE crew station; soldier-machine interface; digital command and control; human factors engineering C1 USA,TANK AUTOMOT RES DEV & ENGN CTR,VETRON TECHNOL AREA,WARREN,MI 48397. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPIE - INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 BN 0-8194-2145-6 J9 P SOC PHOTO-OPT INS PY 1996 VL 2764 BP 66 EP 79 DI 10.1117/12.242079 PG 14 WC Optics SC Optics GA BF76T UT WOS:A1996BF76T00007 ER PT B AU Kalomiris, VE Hafer, TF AF Kalomiris, VE Hafer, TF BE Suresh, R TI Commercial communications technology on the digital battlefield SO DIGITIZATION OF THE BATTLEFIELD SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT 1st International Symposium on Digitization of the Battlefield CY APR 10-11, 1996 CL ORLANDO, FL SP Soc Photo Opt Instrumentat Engineers DE communications; wireless; trunking; commercial technology; PCS; Department of Defense; battlefield digitization; MSE; system addressing; fault tolerance C1 USA,COMMUN ELECT COMMAND RES DEV & ENGN CTR,SPACE & TERR COMMUN DIRECTORATE,SPECIAL PROJECTS OFF,FT MONMOUTH,NJ 07703. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPIE - INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 BN 0-8194-2145-6 J9 P SOC PHOTO-OPT INS PY 1996 VL 2764 BP 126 EP 131 DI 10.1117/12.242070 PG 6 WC Optics SC Optics GA BF76T UT WOS:A1996BF76T00012 ER PT B AU Brooks, JA Gallo, MA AF Brooks, JA Gallo, MA BE Suresh, R TI Remote Sentry advanced technology demonstration SO DIGITIZATION OF THE BATTLEFIELD SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT 1st International Symposium on Digitization of the Battlefield CY APR 10-11, 1996 CL ORLANDO, FL SP Soc Photo Opt Instrumentat Engineers DE autonomous/unmanned; surveillance; target acquisition; acoustic sensors; uncooled FLIR; image transmission; RFPI; Remote Sentry C1 USA,NIGHT VIS & ELECT SENSORS DIRECTORATE,FT BELVOIR,VA 22060. NR 0 TC 2 Z9 2 U1 0 U2 0 PU SPIE - INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 BN 0-8194-2145-6 J9 P SOC PHOTO-OPT INS PY 1996 VL 2764 BP 154 EP 164 PG 11 WC Optics SC Optics GA BF76T UT WOS:A1996BF76T00015 ER PT B AU Mackin, JP Wiltsie, DK AF Mackin, JP Wiltsie, DK BE Suresh, R TI The US Army Development of the Second Generation Horizontal Technology Integration Forward Looking Infrared (NIR) SO DIGITIZATION OF THE BATTLEFIELD SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT 1st International Symposium on Digitization of the Battlefield CY APR 10-11, 1996 CL ORLANDO, FL SP Soc Photo Opt Instrumentat Engineers C1 USA,FLIR,WASHINGTON,DC 20310. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPIE - INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 BN 0-8194-2145-6 J9 P SOC PHOTO-OPT INS PY 1996 VL 2764 BP 188 EP 194 DI 10.1117/12.242077 PG 7 WC Optics SC Optics GA BF76T UT WOS:A1996BF76T00019 ER PT S AU Segars, R Piscitelle, L AF Segars, R Piscitelle, L BE Cummins, HZ Durian, DJ Johnson, DL Stanley, HE TI Verification and application of a new adsorption model for fractal surfaces SO DISORDERED MATERIALS AND INTERFACES SE MATERIALS RESEARCH SOCIETY SYMPOSIUM PROCEEDINGS LA English DT Proceedings Paper CT Symposium on Disordered Materials and Interfaces CY NOV 27-30, 1995 CL BOSTON, MA SP Mat Res Soc C1 USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. NR 0 TC 2 Z9 2 U1 0 U2 0 PU MATERIALS RESEARCH SOC PI PITTSBURGH PA 9800 MCKNIGHT RD, SUITE 327, PITTSBURGH, PA 15237 SN 0272-9172 BN 1-55899-310-X J9 MATER RES SOC SYMP P PY 1996 VL 407 BP 349 EP 354 PG 6 WC Chemistry, Physical; Materials Science, Multidisciplinary; Physics, Atomic, Molecular & Chemical SC Chemistry; Materials Science; Physics GA BF25P UT WOS:A1996BF25P00053 ER PT J AU Capacio, BR Byers, CE Anderson, DR Matthews, RL Brown, DE AF Capacio, BR Byers, CE Anderson, DR Matthews, RL Brown, DE TI The effect of ondansetron on pyridostigmine-induced blood acetylcholinesterase inhibition in the guinea pig SO DRUG AND CHEMICAL TOXICOLOGY LA English DT Article ID 5-HT3-RECEPTOR ANTAGONIST; RECEPTOR ANTAGONISM; 5-HT3 RECEPTORS; GR38032F; PRETREATMENT; METABOLISM; EMESIS AB The purpose of this study was to assess the compatibility, in terms of red blood cell acetylcholinesterase (AChE) inhibition, of ondansetron (OND; a 5-hydroxytryptamine subtype-3 receptor antagonist) with the organophosphorus pretreatment compound pyridostigmine (PYR) after simultaneous oral (p.o.) administration to guinea pigs. The time-course of PYR-induced (0.94 mg/kg, p.o.) AChE inhibition was determined in the absence and presence of OND. Ondansetron (10, 20 and 30 mg/kg; p.o.) did not modify AChE inhibition, whereas concurrent administration of PYR with OND (10 or 20 mg/kg; p.o.) produced significantly greater decreases in AChE activity than PYR alone. The decreases in AChE activity for PYR plus OND, 10 and 20 mg/kg, (between 30 - 240 min) were 12.3 +/- 2.8% and 16.1 +/- 2.3% (mean +/- SD) respectively relative to PYR alone. The slope for recovery of AChE activity (120 - 240 min) was 0.0914 for PYR alone; recovery rates (slopes) for PYR plus OND, 10 and 20 mg/kg, were 0.0796 and 0.0433 respectively. Additionally, altered PYR-induced AChE activity profiles were ameliorated when PYR and OND) (20 mg/kg) were administered 150 min apart. Since the results of this study provided evidence that the oral administration of OND alone did not inhibit AChE, the changes in PYR-induced AChE activity by the simultaneous administration of OND suggest mechanisms other than a direct action on the enzyme. The significance of these findings is that the increased AChE inhibition resulting from simultaneous oral administration of both compounds could result in undesirable cholinergic toxicities and subsequent performance decrements. RP Capacio, BR (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 29 TC 1 Z9 1 U1 0 U2 1 PU MARCEL DEKKER INC PI NEW YORK PA 270 MADISON AVE, NEW YORK, NY 10016 SN 0148-0545 J9 DRUG CHEM TOXICOL JI Drug Chem. Toxicol. PY 1996 VL 19 IS 1-2 BP 1 EP 19 DI 10.3109/01480549609002193 PG 19 WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy; Toxicology SC Chemistry; Pharmacology & Pharmacy; Toxicology GA UQ005 UT WOS:A1996UQ00500001 PM 8804550 ER PT B AU Flanigan, DF AF Flanigan, DF BE Fallahi, M Howden, E TI A short history of remote sensing of chemical agents SO ELECTRO-OPTICAL TECHNOLOGY FOR REMOTE CHEMICAL DETECTION AND IDENTIFICATION SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Electro-Optical Technology for Remote Chemical Detection and Identification CY APR 08-09, 1996 CL ORLANDO, FL SP Soc Photo Opt Instrumentat Engineers DE hazardous vapor detection; chemical warfare; infrared; alarm; laser; active infrared; passive infrared C1 USA,EDGEWOOD RES DEV & ENGN CTR,CHEM BIOL DEF COMMAND,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 8 Z9 8 U1 0 U2 1 PU SPIE - INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 BN 0-8194-2144-8 J9 P SOC PHOTO-OPT INS PY 1996 VL 2763 BP 2 EP 17 DI 10.1117/12.243268 PG 16 WC Remote Sensing; Optics SC Remote Sensing; Optics GA BF87V UT WOS:A1996BF87V00001 ER PT B AU Althouse, MLG Gross, RL Ditillo, JT Lagna, WM Kolodzey, SJ Keiser, CC Nasers, GD AF Althouse, MLG Gross, RL Ditillo, JT Lagna, WM Kolodzey, SJ Keiser, CC Nasers, GD BE Fallahi, M Howden, E TI Applications and testing of the LSCAD system SO ELECTRO-OPTICAL TECHNOLOGY FOR REMOTE CHEMICAL DETECTION AND IDENTIFICATION SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Electro-Optical Technology for Remote Chemical Detection and Identification CY APR 08-09, 1996 CL ORLANDO, FL SP Soc Photo Opt Instrumentat Engineers DE remote; chemical; agent; detection; military; defense; vapor; infrared; mobile; tactical C1 USA,CHEM & BIOL DEF COMMAND,AMCPM,NNS,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 1 Z9 1 U1 0 U2 0 PU SPIE - INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 BN 0-8194-2144-8 J9 P SOC PHOTO-OPT INS PY 1996 VL 2763 BP 33 EP 40 DI 10.1117/12.243281 PG 8 WC Remote Sensing; Optics SC Remote Sensing; Optics GA BF87V UT WOS:A1996BF87V00003 ER PT B AU Flanigan, DF AF Flanigan, DF BE Fallahi, M Howden, E TI Limits of passive remote detection of hazardous vapors by computer simulation SO ELECTRO-OPTICAL TECHNOLOGY FOR REMOTE CHEMICAL DETECTION AND IDENTIFICATION SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Electro-Optical Technology for Remote Chemical Detection and Identification CY APR 08-09, 1996 CL ORLANDO, FL SP Soc Photo Opt Instrumentat Engineers DE remote detection; stand-off detection; hazardous vapors infrared; Fourier transform infrared C1 USA,EDGEWOOD RES DEV & ENGN CTR,CHEM & BIOL DEF COMMAND,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 2 Z9 2 U1 0 U2 0 PU SPIE - INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 BN 0-8194-2144-8 J9 P SOC PHOTO-OPT INS PY 1996 VL 2763 BP 117 EP 127 DI 10.1117/12.243272 PG 11 WC Remote Sensing; Optics SC Remote Sensing; Optics GA BF87V UT WOS:A1996BF87V00011 ER PT J AU Smallridge, RC AF Smallridge, RC TI Postpartum thyroid dysfunction: A frequently undiagnosed endocrine disorder SO ENDOCRINOLOGIST LA English DT Review ID TERM FOLLOW-UP; LYMPHOCYTIC THYROIDITIS; MICROSOMAL ANTIBODIES; DIABETES-MELLITUS; CLINICAL COURSE; PREGNANT-WOMEN; HYPOTHYROIDISM; PREVALENCE; ASSOCIATION; DEPRESSION C1 WALTER REED ARMY INST RES, DIV MED, WASHINGTON, DC 20307 USA. NR 55 TC 10 Z9 10 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1051-2144 EI 1539-9192 J9 ENDOCRINOLOGIST JI Endocrinologist PD JAN PY 1996 VL 6 IS 1 BP 44 EP 50 DI 10.1097/00019616-199601000-00007 PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA TT613 UT WOS:A1996TT61300007 ER PT B AU Chowdhury, MR Hall, RL AF Chowdhury, MR Hall, RL BE Lin, YK Su, TC TI Flow-induced dynamic response of olmsted physical models SO ENGINEERING MECHANICS: PROCEEDINGS OF THE 11TH CONFERENCE, VOLS 1 AND 2 LA English DT Proceedings Paper CT 11th Engineering Mechanics Conference CY MAY 19-22, 1996 CL FT LAUDERDALE, FL SP Amer Soc Civil Engineers, Engn Mech Div, Appl Stochast Res, Florida Atlantic Univ Ctr C1 USA,ENGINEER WATERWAYS EXPT STN,STRUCT LAB,VICKSBURG,MS 39180. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CIVIL ENGINEERS PI NEW YORK PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 BN 0-7844-0172-1 PY 1996 BP 840 EP 843 PG 4 WC Engineering, Civil; Mechanics SC Engineering; Mechanics GA BG42L UT WOS:A1996BG42L00208 ER PT J AU Owen, SJ Jones, NL Holland, JP AF Owen, SJ Jones, NL Holland, JP TI A comprehensive modeling environment for the simulation of groundwater flow and transport SO ENGINEERING WITH COMPUTERS LA English DT Article; Proceedings Paper CT 3rd International Meshing Roundtable CY OCT 24-25, 1994 CL ALBUQUERQUE, NM DE environmental engineering; finite elements; groundwater modeling; mesh generation AB A comprehensive graphical modeling environment has been developed to address the needs of the computer simulation of groundwater flow and transport. The Department of Defense Groundwater Modeling Systems (GMS), developed at rite Engineering Computer Graphics Laboratory at Brigham Young University, is part of a multi-year project funded through the Department of Defense, Department of Energy and Environmental Protection Agency. GMS is a graphically based software tool providing facility through all aspects of the groundwater flow and transport modeling process. Facilities include geometric modeling of hydrostratigraphy, two- and three-dimensional mesh generation, graphically based model input for specific pow and transport codes, interpolation and geostatistics as well as complete three-dimensional scientific visualization. C1 BRIGHAM YOUNG UNIV,PROVO,UT 84602. WATERWAYS EXPT STN,VICKSBURG,MS. NR 12 TC 18 Z9 18 U1 0 U2 6 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0177-0667 J9 ENG COMPUT JI Eng. Comput. PY 1996 VL 12 IS 3-4 BP 235 EP 242 DI 10.1007/BF01198737 PG 8 WC Computer Science, Interdisciplinary Applications; Engineering, Mechanical SC Computer Science; Engineering GA VT663 UT WOS:A1996VT66300009 ER PT B AU OKane, BL AF OKane, BL BE Verly, JG TI Driving with indirect viewing sensors: Understanding the visual perception issues SO ENHANCED AND SYNTHETIC VISION 1996 SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT 1996 Conference on Enhanced and Synthetic Vision CY APR 08-10, 1996 CL ORLANDO, FL SP Soc Photo Opt Instrumentat Engineers DE driving; visual perception; cues; FLIR; scene perception; thermal imagery; night vision C1 USA,CECOM,RDEC,NIGHT VIS & ELECTR SENSORS DIRECTORATE,FT BELVOIR,VA 22060. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPIE - INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 BN 0-8194-2117-0 J9 P SOC PHOTO-OPT INS PY 1996 VL 2736 BP 248 EP 258 DI 10.1117/12.241040 PG 11 WC Engineering, Aerospace; Computer Science, Cybernetics; Optics SC Engineering; Computer Science; Optics GA BF76Q UT WOS:A1996BF76Q00027 ER PT S AU Yu, H Stopa, PJ AF Yu, H Stopa, PJ BE VanEmon, JM Gerlach, CL Johnson, JC TI Application of an immunomagnetic assay system for detection of virulent bacteria in biological samples SO ENVIRONMENTAL IMMUNOCHEMICAL METHODS: PERSPECTIVES AND APPLICATIONS SE ACS SYMPOSIUM SERIES LA English DT Article; Proceedings Paper CT Symposium on Environmental Immunochemical Methods - Perspectives and Applications, at the National Immunochemistry Summit IV CY AUG 02-03, 1995 CL LAS VEGAS, NV SP US EPA ID LABELED ANTIBODY PROCEDURE; ESCHERICHIA-COLI 0157; ELECTROCHEMILUMINESCENCE; FOODS AB Virulent pathogenic bacteria could pose a serious health threat in contaminated food and water resources. Traditional bacterial culture methods or enzyme linked immunosorbent assay (ELISA) for identification of the bacteria are time consuming and labor intensive. Some new technologies are very sensitive but analysis time can be lengthy. For example, the polymerase chain reaction (PCR) can be used to amplify small quantities of genetic material to determine the presence of bacteria. This is a sensitive method that requires pure samples and considerable laboratory time. Alternative methods should be quicker and retain sensitivity. The magnetic separation technique appears promising for rapid bacterial isolation from the media prior to the detection. In this work, immunomagnetic assay system (IMAS) has been coupled to an electrochemiluminescent (ECL) technology for rapid and sensitive bacterial detection of biological samples within an hour. The sensitivity of the IMAS-ECL for Bacillus anthrax spores (sterne), Escherichia coli O157:H7 and Salmonella typhimurium detection is about 1000 cells/mL, in biological samples. In addition, IMAS can also be coupled to a now cytometer or any analytical instruments for target agent monitoring. Results of this study strongly suggest that IMAS methodology is useful for rapid and sensitive detection. C1 USA,CTR DEV & ENGN,EDGEWOOD RES,RTE,SCBRD,ABERDEEN PROVING GROUND,MD 21010. RP Yu, H (reprint author), USA,CTR DEV & ENGN,EDGEWOOD RES,CALSPAN SRL CORP,BLDG E 3549,ABERDEEN PROVING GROUND,MD 21010, USA. NR 11 TC 7 Z9 7 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 SN 0097-6156 BN 0-8412-3454-X J9 ACS SYM SER PY 1996 VL 646 BP 297 EP 306 PG 10 WC Chemistry, Multidisciplinary; Chemistry, Analytical SC Chemistry GA BG68A UT WOS:A1996BG68A00025 ER PT J AU Roper, JM Cherry, DS Simmers, JW Tatem, HE AF Roper, JM Cherry, DS Simmers, JW Tatem, HE TI Bioaccumulation of toxicants in the zebra mussel, Dreissena polymorpha, at the Times Beach Confined Disposal Facility, Buffalo, New York SO ENVIRONMENTAL POLLUTION LA English DT Article DE Times Beach CDF; Dreissena polymorpha; Daphnia magna; PAHs; PCBs; metals ID POLYCYCLIC AROMATIC-HYDROCARBONS; DIVING DUCKS; SEDIMENTS; CONTAMINANTS; TOXICITY; INVASION AB This study consisted of a site characterization followed by biomonitoring the zebra mussel, Dreissena polymorpha, at the Times Beach Confined Disposal Facility (CDF), located in Buffalo, New York. Concentrations of selected contaminants, polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs) and metals - arsenic (As), chromium (Cr), barium (Ba), mercury (Hg), cadmium (Cd), lead (Pb), selenium (Se) and silver (Ag) - were at or below detection limits in the water column. Sediment contaminant concentrations, recorded as dry weight, were as high as 549 mg/kg for total PAHs, 9 mg/kg for PCB Aroclor 1248 and 54, 99, 6, 355, 637 and 16 mg/kg for the metals As, Ba, Cd, CI, Pb and Hg, respectively. To predict contaminant bioavailability, elutriate and whole sediment toxicity tests were performed utilizing the cladoceran, Daphnia magna. Whole sediment tests indicated significant impact. Control survival was 84%, while sediment treatment had survival ranging from I to 7%. Mean control reproduction was 86.8 neonates, whereas treatment reproduction ranged from 1.4 to 9.0. Zebra mussels placed both in the water column (Upper) and at the sediment level (Lower) survived the 34-day exposure. Contaminants that significantly accumulated in zebra mussel tissue (wet wt mg/kg) were total PAHs (6.58), fluoranthene (1.23), pyrene (1.08), chrysene (0.98), benzo(a)anthracene (0.60), PCB Aroclor 1248 (1.64), As (0.97), Cr (2.87) and Ba (7.00). Accumulation of these contaminants in zebra mussel tissue represent a potentially realistic hazard to organisms (i.e. fish and birds) that feed on them. (C) 1997 Elsevier Science Ltd. C1 VIRGINIA POLYTECH INST & STATE UNIV,BLACKSBURG,VA 24061. RP Roper, JM (reprint author), USA,WATERWAYS EXPT STN,ENVIRON LAB,ARMY ENGN,ES-F,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 52 TC 28 Z9 29 U1 4 U2 26 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0269-7491 J9 ENVIRON POLLUT JI Environ. Pollut. PY 1996 VL 94 IS 2 BP 117 EP & DI 10.1016/S0269-7491(96)00083-8 PG 12 WC Environmental Sciences SC Environmental Sciences & Ecology GA WJ298 UT WOS:A1996WJ29800002 PM 15093498 ER PT S AU Tidrow, SC Lareau, RT King, LLH Eckart, DW Tauber, A Wilber, WD Pfeffer, RL Finnegan, RD Neal, M AF Tidrow, SC Lareau, RT King, LLH Eckart, DW Tauber, A Wilber, WD Pfeffer, RL Finnegan, RD Neal, M BE Speck, JS Fork, DK Wolf, RM Shiosaki, T TI Oxygen diffusion coefficients for Sr2AlTaO6: Ramifications on HTSC multilayer processing SO EPITAXIAL OXIDE THIN FILMS II SE MATERIALS RESEARCH SOCIETY SYMPOSIUM PROCEEDINGS LA English DT Proceedings Paper CT Symposium on Epitaxial Oxide Thin Films II, at the 1995 MRS Fall Meeting CY NOV 26-30, 1995 CL BOSTON, MA SP Mat Res Soc C1 USA,RES LAB,AMSRL,PS,PC,FT MONMOUTH,NJ 07703. RI Tidrow, Steven/C-8133-2013 NR 0 TC 0 Z9 0 U1 0 U2 4 PU MATERIALS RESEARCH SOC PI PITTSBURGH PA 9800 MCKNIGHT RD, SUITE 327, PITTSBURGH, PA 15237 SN 0272-9172 BN 1-55899-304-5 J9 MATER RES SOC SYMP P PY 1996 VL 401 BP 363 EP 368 PG 6 WC Materials Science, Coatings & Films SC Materials Science GA BF25N UT WOS:A1996BF25N00050 ER PT B AU Mendrop, KB Little, CD AF Mendrop, KB Little, CD GP INT EROSION CONTROL ASSOC TI Grade stabilization requirements for incised channels SO EROSION CONTROL TECHNOLOGY - BRINGING IT HOME: PROCEEDINGS OF CONFERENCE XXVII LA English DT Proceedings Paper CT International-Erosion-Control-Association Conference XXVII on Erosion Control Technology - Bringing It Home CY FEB 27-MAR 01, 1996 CL SEATTLE, WA SP Int Erosion Control Assoc C1 USA,CORPS ENGINEERS,VICKSBURG,MS 39180. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INT EROSION CONTROL ASSOC PI STEAMBOAT SPRINGS PA PO BOX 4904, STEAMBOAT SPRINGS, CO 80477 PY 1996 BP 181 EP 193 PG 13 WC Engineering, Environmental; Engineering, Marine; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA BF95L UT WOS:A1996BF95L00017 ER PT B AU Derrick, DL AF Derrick, DL GP INT EROSION CONTROL ASSOC TI The Bendway Weir: An in-stream erosion control and habitat improvement structure for the 1990's SO EROSION CONTROL TECHNOLOGY - BRINGING IT HOME: PROCEEDINGS OF CONFERENCE XXVII LA English DT Proceedings Paper CT International-Erosion-Control-Association Conference XXVII on Erosion Control Technology - Bringing It Home CY FEB 27-MAR 01, 1996 CL SEATTLE, WA SP Int Erosion Control Assoc C1 USA,WATERWAYS EXPT STN,HYDRAUL LAB,VICKSBURG,MS 39180. NR 0 TC 0 Z9 0 U1 2 U2 2 PU INT EROSION CONTROL ASSOC PI STEAMBOAT SPRINGS PA PO BOX 4904, STEAMBOAT SPRINGS, CO 80477 PY 1996 BP 227 EP 241 PG 15 WC Engineering, Environmental; Engineering, Marine; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA BF95L UT WOS:A1996BF95L00020 ER PT J AU RIDDLE, WA AF RIDDLE, WA TI THE OLD-WORLD AND NEW, 1492-1650 - ELLIOTT,JH SO EUROPEAN HISTORY QUARTERLY LA English DT Book Review RP RIDDLE, WA (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU SAGE PUBLICATIONS LTD PI LONDON PA 6 BONHILL STREET, LONDON, ENGLAND EC2A 4PU SN 0014-3111 J9 EUR HIST Q JI Eur. Hist. Q. PD JAN PY 1996 VL 26 IS 1 BP 169 EP 171 DI 10.1177/026569149602600114 PG 3 WC History; Political Science SC History; Government & Law GA TQ821 UT WOS:A1996TQ82100020 ER PT S AU Gray, A Dhar, NK Clark, W Charlton, P Dinan, JH Segnan, R Mayo, WE AF Gray, A Dhar, NK Clark, W Charlton, P Dinan, JH Segnan, R Mayo, WE BE Zangwill, A Jesson, D Chambliss, D Clarke, R TI Twinning in epilayers of CdTe on <211>Si: Influence of ZnTe buffer layer and substrate misorientation SO EVOLUTION OF EPITAXIAL STRUCTURE AND MORPHOLOGY SE MATERIALS RESEARCH SOCIETY SYMPOSIUM PROCEEDINGS LA English DT Proceedings Paper CT Symposium on Evolution of Epitaxial Structure and Morphology CY NOV 27-DEC 01, 1995 CL BOSTON, MA SP Mat Res Soc C1 USA,RES LAB,FT BELVOIR,VA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MATERIALS RESEARCH SOC PI PITTSBURGH PA 9800 MCKNIGHT RD, SUITE 327, PITTSBURGH, PA 15237 SN 0272-9172 BN 1-55899-302-9 J9 MATER RES SOC SYMP P PY 1996 VL 399 BP 479 EP 484 PG 6 WC Materials Science, Multidisciplinary SC Materials Science GA BF87P UT WOS:A1996BF87P00069 ER EF